Search of human proteins with 21361306

Search of human proteins with 21361306

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|21361306 neurotrophic tyrosine kinase, receptor, type 2
isoform a precursor [Homo sapiens]
         (838 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isofo...  1741   0.0  
gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isofo...  1696   0.0  
gi|65506769 neurotrophic tyrosine kinase, receptor, type 2 isofo...  1134   0.0  
gi|65506779 neurotrophic tyrosine kinase, receptor, type 2 isofo...  1089   0.0  
gi|55956790 neurotrophic tyrosine kinase, receptor, type 2 isofo...   975   0.0  
gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isofo...   858   0.0  
gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isofo...   848   0.0  
gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isofo...   709   0.0  
gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isofor...   709   0.0  
gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isofo...   697   0.0  
gi|55956794 neurotrophic tyrosine kinase, receptor, type 3 isofo...   355   7e-98
gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens]    290   5e-78
gi|134152725 receptor tyrosine kinase-like orphan receptor 1 iso...   254   3e-67
gi|62420886 discoidin domain receptor family, member 2 precursor...   253   4e-67
gi|62420884 discoidin domain receptor family, member 2 precursor...   253   4e-67
gi|38327632 discoidin domain receptor family, member 1 isoform b...   247   3e-65
gi|83977450 discoidin domain receptor family, member 1 isoform a...   247   3e-65
gi|19743898 receptor tyrosine kinase-like orphan receptor 2 prec...   246   6e-65
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo...   245   1e-64
gi|119395738 insulin receptor isoform Short precursor [Homo sapi...   244   2e-64
gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]   244   2e-64
gi|83977452 discoidin domain receptor family, member 1 isoform c...   241   3e-63
gi|31657140 insulin receptor-related receptor precursor [Homo sa...   238   2e-62
gi|29029632 anaplastic lymphoma kinase [Homo sapiens]                 231   2e-60
gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [...   224   3e-58
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu...   220   5e-57
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs...   219   6e-57
gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precurs...   218   2e-56
gi|46249416 leukocyte receptor tyrosine kinase isoform 2 precurs...   218   2e-56
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu...   214   3e-55

>gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isoform
           a precursor [Homo sapiens]
          Length = 838

 Score = 1741 bits (4508), Expect = 0.0
 Identities = 838/838 (100%), Positives = 838/838 (100%)

Query: 1   MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP 60
           MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP
Sbjct: 1   MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP 60

Query: 61  NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI 120
           NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI
Sbjct: 61  NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI 120

Query: 121 NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES 180
           NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES
Sbjct: 121 NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES 180

Query: 181 SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM 240
           SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM
Sbjct: 181 SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM 240

Query: 241 NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH 300
           NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH
Sbjct: 241 NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH 300

Query: 301 WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT 360
           WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT
Sbjct: 301 WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT 360

Query: 361 LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST 420
           LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST
Sbjct: 361 LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST 420

Query: 421 DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQG 480
           DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQG
Sbjct: 421 DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQG 480

Query: 481 VGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQL 540
           VGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQL
Sbjct: 481 VGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQL 540

Query: 541 KPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKD 600
           KPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKD
Sbjct: 541 KPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKD 600

Query: 601 FHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNP 660
           FHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNP
Sbjct: 601 FHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNP 660

Query: 661 PTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYST 720
           PTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYST
Sbjct: 661 PTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYST 720

Query: 721 DYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIE 780
           DYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIE
Sbjct: 721 DYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIE 780

Query: 781 CITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 838
           CITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG
Sbjct: 781 CITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 838


>gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isoform
           c precursor [Homo sapiens]
          Length = 822

 Score = 1696 bits (4392), Expect = 0.0
 Identities = 822/838 (98%), Positives = 822/838 (98%), Gaps = 16/838 (1%)

Query: 1   MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP 60
           MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP
Sbjct: 1   MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP 60

Query: 61  NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI 120
           NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI
Sbjct: 61  NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI 120

Query: 121 NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES 180
           NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES
Sbjct: 121 NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES 180

Query: 181 SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM 240
           SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM
Sbjct: 181 SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM 240

Query: 241 NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH 300
           NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH
Sbjct: 241 NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH 300

Query: 301 WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT 360
           WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT
Sbjct: 301 WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT 360

Query: 361 LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST 420
           LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST
Sbjct: 361 LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST 420

Query: 421 DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQG 480
           DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMK               
Sbjct: 421 DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMK--------------- 465

Query: 481 VGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQL 540
            GPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQL
Sbjct: 466 -GPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQL 524

Query: 541 KPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKD 600
           KPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKD
Sbjct: 525 KPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKD 584

Query: 601 FHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNP 660
           FHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNP
Sbjct: 585 FHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNP 644

Query: 661 PTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYST 720
           PTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYST
Sbjct: 645 PTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYST 704

Query: 721 DYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIE 780
           DYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIE
Sbjct: 705 DYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIE 764

Query: 781 CITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 838
           CITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG
Sbjct: 765 CITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 822


>gi|65506769 neurotrophic tyrosine kinase, receptor, type 2 isoform
           d precursor [Homo sapiens]
          Length = 553

 Score = 1134 bits (2933), Expect = 0.0
 Identities = 544/545 (99%), Positives = 545/545 (100%)

Query: 1   MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP 60
           MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP
Sbjct: 1   MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP 60

Query: 61  NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI 120
           NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI
Sbjct: 61  NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI 120

Query: 121 NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES 180
           NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES
Sbjct: 121 NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES 180

Query: 181 SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM 240
           SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM
Sbjct: 181 SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM 240

Query: 241 NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH 300
           NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH
Sbjct: 241 NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH 300

Query: 301 WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT 360
           WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT
Sbjct: 301 WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT 360

Query: 361 LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST 420
           LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST
Sbjct: 361 LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST 420

Query: 421 DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQG 480
           DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQG
Sbjct: 421 DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQG 480

Query: 481 VGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQL 540
           VGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQL
Sbjct: 481 VGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQL 540

Query: 541 KPDTF 545
           KPDT+
Sbjct: 541 KPDTW 545


>gi|65506779 neurotrophic tyrosine kinase, receptor, type 2 isoform
           e precursor [Homo sapiens]
          Length = 537

 Score = 1089 bits (2817), Expect = 0.0
 Identities = 528/545 (96%), Positives = 529/545 (97%), Gaps = 16/545 (2%)

Query: 1   MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP 60
           MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP
Sbjct: 1   MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP 60

Query: 61  NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI 120
           NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI
Sbjct: 61  NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI 120

Query: 121 NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES 180
           NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES
Sbjct: 121 NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES 180

Query: 181 SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM 240
           SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM
Sbjct: 181 SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM 240

Query: 241 NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH 300
           NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH
Sbjct: 241 NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH 300

Query: 301 WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT 360
           WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT
Sbjct: 301 WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT 360

Query: 361 LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST 420
           LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST
Sbjct: 361 LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST 420

Query: 421 DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQG 480
           DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMK               
Sbjct: 421 DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMK--------------- 465

Query: 481 VGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQL 540
            GPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQL
Sbjct: 466 -GPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQL 524

Query: 541 KPDTF 545
           KPDT+
Sbjct: 525 KPDTW 529


>gi|55956790 neurotrophic tyrosine kinase, receptor, type 2 isoform
           b precursor [Homo sapiens]
          Length = 477

 Score =  975 bits (2521), Expect = 0.0
 Identities = 467/470 (99%), Positives = 467/470 (99%)

Query: 1   MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP 60
           MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP
Sbjct: 1   MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP 60

Query: 61  NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI 120
           NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI
Sbjct: 61  NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI 120

Query: 121 NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES 180
           NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES
Sbjct: 121 NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES 180

Query: 181 SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM 240
           SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM
Sbjct: 181 SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM 240

Query: 241 NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH 300
           NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH
Sbjct: 241 NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH 300

Query: 301 WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT 360
           WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT
Sbjct: 301 WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT 360

Query: 361 LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST 420
           LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST
Sbjct: 361 LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST 420

Query: 421 DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWF 470
           DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMK F  F
Sbjct: 421 DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGFVLF 470


>gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isoform
           b precursor [Homo sapiens]
          Length = 825

 Score =  858 bits (2216), Expect = 0.0
 Identities = 464/865 (53%), Positives = 573/865 (66%), Gaps = 82/865 (9%)

Query: 10  PAMARLW-----GFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP---- 60
           PA    W     G  WL   +  +  ACP +C CS + I C  P  G + FP LE     
Sbjct: 7   PAKCSFWRIFLLGSVWL--DYVGSVLACPANCVCSKTEINCRRPDDGNL-FPLLEGQDSG 63

Query: 61  --------NSVD-PENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAF 111
                   N  D   NIT I I N + L  +N  D+E Y GL+ LTI +SGL+ +  +AF
Sbjct: 64  NSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAF 123

Query: 112 LKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQE-AKSSPD 170
            KN +L++IN + N+LT+LS + F+ L L EL L  N F CSCDI W++  QE  ++  +
Sbjct: 124 AKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLN 183

Query: 171 TQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYW 230
           +Q+LYC+N     +PL  + I  C LP  +++  NLTV EG +  ++C+ +G P+P++ W
Sbjct: 184 SQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDW 243

Query: 231 DVGNLVS-----KHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHF 285
            V  L S      ++N T+    +L + N++S+D+G  ++C+AEN+VG    SV LTV++
Sbjct: 244 IVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYY 303

Query: 286 APTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYH-- 343
            P +  LE P      CI F V+GNP P L W +NG  L ESK I        H EY+  
Sbjct: 304 PPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKII--------HVEYYQE 355

Query: 344 -----GCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYE 398
                GCL  + PTH NNG+YTLIAKN  G   + I+ HF+  P  +   N     ++++
Sbjct: 356 GEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDN----FILFD 411

Query: 399 DYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLL--KL 456
           +                  P   VT K   +   V   V +A+     LLV+LF++  K 
Sbjct: 412 EVSPT--------------PPITVTHKPEEDTFGVSIAVGLAAFA-CVLLVVLFVMINKY 456

Query: 457 ARHSKFGMKDFSWFGFGKVKSRQGVGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDA 516
            R SKFGMK                GP +VIS ++DSASPLHHI++G  TPSS + GPD 
Sbjct: 457 GRRSKFGMK----------------GPVAVISGEEDSASPLHHINHGITTPSSLDAGPDT 500

Query: 517 VIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNL 576
           V+IGMT+IPVIENPQYF   ++  KPDT+VQHIKR +IVLKRELGEGAFGKVFLAECYNL
Sbjct: 501 VVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNL 560

Query: 577 CPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYM 636
            P +DK+LVAVK LKD +  ARKDF REAELLTNLQHEHIVKFYGVC +GDPLIMVFEYM
Sbjct: 561 SPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYM 620

Query: 637 KHGDLNKFLRAHGPDAVLMAEGNPPT---ELTQSQMLHIAQQIAAGMVYLASQHFVHRDL 693
           KHGDLNKFLRAHGPDA+++ +G P     EL  SQMLHIA QIA+GMVYLASQHFVHRDL
Sbjct: 621 KHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDL 680

Query: 694 ATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVW 753
           ATRNCLVG NLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVW
Sbjct: 681 ATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVW 740

Query: 754 SLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMR 813
           S GV+LWEIFTYGKQPW+QLSN EVIECITQGRVL+RPR CP+EVY++MLGCWQREP  R
Sbjct: 741 SFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQR 800

Query: 814 KNIKGIHTLLQNLAKASPVYLDILG 838
            NIK I+ +L  L KA+P+YLDILG
Sbjct: 801 LNIKEIYKILHALGKATPIYLDILG 825


>gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isoform
           a precursor [Homo sapiens]
          Length = 839

 Score =  848 bits (2191), Expect = 0.0
 Identities = 464/879 (52%), Positives = 573/879 (65%), Gaps = 96/879 (10%)

Query: 10  PAMARLW-----GFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP---- 60
           PA    W     G  WL   +  +  ACP +C CS + I C  P  G + FP LE     
Sbjct: 7   PAKCSFWRIFLLGSVWL--DYVGSVLACPANCVCSKTEINCRRPDDGNL-FPLLEGQDSG 63

Query: 61  --------NSVD-PENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAF 111
                   N  D   NIT I I N + L  +N  D+E Y GL+ LTI +SGL+ +  +AF
Sbjct: 64  NSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAF 123

Query: 112 LKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQE-AKSSPD 170
            KN +L++IN + N+LT+LS + F+ L L EL L  N F CSCDI W++  QE  ++  +
Sbjct: 124 AKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLN 183

Query: 171 TQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYW 230
           +Q+LYC+N     +PL  + I  C LP  +++  NLTV EG +  ++C+ +G P+P++ W
Sbjct: 184 SQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDW 243

Query: 231 DVGNLVS-----KHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHF 285
            V  L S      ++N T+    +L + N++S+D+G  ++C+AEN+VG    SV LTV++
Sbjct: 244 IVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYY 303

Query: 286 APTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYH-- 343
            P +  LE P      CI F V+GNP P L W +NG  L ESK I        H EY+  
Sbjct: 304 PPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKII--------HVEYYQE 355

Query: 344 -----GCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYE 398
                GCL  + PTH NNG+YTLIAKN  G   + I+ HF+  P  +   N     ++++
Sbjct: 356 GEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDN----FILFD 411

Query: 399 DYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLL--KL 456
           +                  P   VT K   +   V   V +A+     LLV+LF++  K 
Sbjct: 412 EVSPT--------------PPITVTHKPEEDTFGVSIAVGLAAFA-CVLLVVLFVMINKY 456

Query: 457 ARHSKFGMKDFSWFGFGKVKSRQGVGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDA 516
            R SKFGMK                GP +VIS ++DSASPLHHI++G  TPSS + GPD 
Sbjct: 457 GRRSKFGMK----------------GPVAVISGEEDSASPLHHINHGITTPSSLDAGPDT 500

Query: 517 VIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNL 576
           V+IGMT+IPVIENPQYF   ++  KPDT+VQHIKR +IVLKRELGEGAFGKVFLAECYNL
Sbjct: 501 VVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNL 560

Query: 577 CPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYM 636
            P +DK+LVAVK LKD +  ARKDF REAELLTNLQHEHIVKFYGVC +GDPLIMVFEYM
Sbjct: 561 SPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYM 620

Query: 637 KHGDLNKFLRAHGPDAVLMAEGNP---PTELTQSQMLHIAQQIAAGMVYLASQHFVHRDL 693
           KHGDLNKFLRAHGPDA+++ +G P     EL  SQMLHIA QIA+GMVYLASQHFVHRDL
Sbjct: 621 KHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDL 680

Query: 694 ATRNCLVGENLLVKIGDFGMSRDVYSTDYYR--------------VGGHTMLPIRWMPPE 739
           ATRNCLVG NLLVKIGDFGMSRDVYSTDYYR              VGGHTMLPIRWMPPE
Sbjct: 681 ATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPE 740

Query: 740 SIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVY 799
           SIMYRKFTTESDVWS GV+LWEIFTYGKQPW+QLSN EVIECITQGRVL+RPR CP+EVY
Sbjct: 741 SIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVY 800

Query: 800 ELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 838
           ++MLGCWQREP  R NIK I+ +L  L KA+P+YLDILG
Sbjct: 801 DVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 839


>gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isoform
           1 [Homo sapiens]
          Length = 790

 Score =  709 bits (1830), Expect = 0.0
 Identities = 403/843 (47%), Positives = 519/843 (61%), Gaps = 75/843 (8%)

Query: 7   WHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVD-- 64
           WH  A        WL++    AA  CP +C        C   S G+        +S+   
Sbjct: 12  WHSWAAGPGSLLAWLILASAGAA-PCPDAC--------CPHGSSGLRCTRDGALDSLHHL 62

Query: 65  --PENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINF 122
              EN+TE++I NQ+ L+ +   D+     LRNLTIV SGL+FVA  AF     L  +N 
Sbjct: 63  PGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNL 122

Query: 123 TRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQE-AKSSPDTQDLYCLNESS 181
           + N L SLS K  + L L EL+L GNP  CSC + W++  +E        Q L C  +  
Sbjct: 123 SFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQG- 181

Query: 182 KNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMN 241
              PLA++   +CG+P+  +  PN +V+ G  + L C V G  +    W +  L      
Sbjct: 182 ---PLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATV 238

Query: 242 ETSHTQGSLRIT--NISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDH 299
             S    SL +T  N++SD + K ++C AEN VG  + SV + V F P    L +    H
Sbjct: 239 MKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSF-PASVQLHTAVEMH 297

Query: 300 HWCIPFTVKGNPKPALQWFYNGAILNESKYICTKI--HVTNHTEYHGCLQLDNPTHMNNG 357
           HWCIPF+V G P P+L+W +NG++LNE+ +I T+      N T  HGCL+L+ PTH+NNG
Sbjct: 298 HWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNG 357

Query: 358 DYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEI 417
           +YTL+A N +G+    I A FM     D+    N  D I +   T+    GD   + +E 
Sbjct: 358 NYTLLAANPFGQASASIMAAFM-----DNPFEFNPEDPIPDTNSTS----GDPVEKKDET 408

Query: 418 PSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKS 477
           P   V+   G   L+V+A + ++++       +L L K  R +KFG              
Sbjct: 409 PF-GVSVAVG---LAVFACLFLSTL-------LLVLNKCGRRNKFG-------------- 443

Query: 478 RQGVGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITN 537
              +   +V++ +D  A  LH ++ G ++ S +EG    +     +  +IENPQYF    
Sbjct: 444 ---INRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGL-----QGHIIENPQYFS--- 492

Query: 538 SQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNA 597
                D  V HIKR +IVLK ELGEGAFGKVFLAEC+NL PEQDK+LVAVK LK+AS++A
Sbjct: 493 -----DACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESA 547

Query: 598 RKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAE 657
           R+DF REAELLT LQH+HIV+F+GVC EG PL+MVFEYM+HGDLN+FLR+HGPDA L+A 
Sbjct: 548 RQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAG 607

Query: 658 GNP--PTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSR 715
           G    P  L   Q+L +A Q+AAGMVYLA  HFVHRDLATRNCLVG+ L+VKIGDFGMSR
Sbjct: 608 GEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSR 667

Query: 716 DVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSN 775
           D+YSTDYYRVGG TMLPIRWMPPESI+YRKFTTESDVWS GVVLWEIFTYGKQPWYQLSN
Sbjct: 668 DIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSN 727

Query: 776 NEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLD 835
            E I+CITQGR L+RPR CP EVY +M GCWQREP  R +IK +H  LQ LA+A PVYLD
Sbjct: 728 TEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLD 787

Query: 836 ILG 838
           +LG
Sbjct: 788 VLG 790


>gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isoform 2
           [Homo sapiens]
          Length = 796

 Score =  709 bits (1830), Expect = 0.0
 Identities = 402/843 (47%), Positives = 517/843 (61%), Gaps = 69/843 (8%)

Query: 7   WHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVD-- 64
           WH  A        WL++    AA  CP +C        C   S G+        +S+   
Sbjct: 12  WHSWAAGPGSLLAWLILASAGAA-PCPDAC--------CPHGSSGLRCTRDGALDSLHHL 62

Query: 65  --PENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINF 122
              EN+TE++I NQ+ L+ +   D+     LRNLTIV SGL+FVA  AF     L  +N 
Sbjct: 63  PGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNL 122

Query: 123 TRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQE-AKSSPDTQDLYCLNESS 181
           + N L SLS K  + L L EL+L GNP  CSC + W++  +E        Q L C  +  
Sbjct: 123 SFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQG- 181

Query: 182 KNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMN 241
              PLA++   +CG+P+  +  PN +V+ G  + L C V G  +    W +  L      
Sbjct: 182 ---PLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATV 238

Query: 242 ETSHTQGSLRIT--NISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDH 299
             S    SL +T  N++SD + K ++C AEN VG  + SV + V F P    L +    H
Sbjct: 239 MKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSF-PASVQLHTAVEMH 297

Query: 300 HWCIPFTVKGNPKPALQWFYNGAILNESKYICTKI--HVTNHTEYHGCLQLDNPTHMNNG 357
           HWCIPF+V G P P+L+W +NG++LNE+ +I T+      N T  HGCL+L+ PTH+NNG
Sbjct: 298 HWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNG 357

Query: 358 DYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEI 417
           +YTL+A N +G+    I A FM  P      NP  P  +        +  GD   + +E 
Sbjct: 358 NYTLLAANPFGQASASIMAAFMDNPF---EFNPEDPIPVSFSPVDTNSTSGDPVEKKDET 414

Query: 418 PSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKS 477
           P   V+   G   L+V+A + ++++       +L L K  R +KFG              
Sbjct: 415 PF-GVSVAVG---LAVFACLFLSTL-------LLVLNKCGRRNKFG-------------- 449

Query: 478 RQGVGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITN 537
              +   +V++ +D  A  LH ++ G ++ S +EG    +     +  +IENPQYF    
Sbjct: 450 ---INRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGL-----QGHIIENPQYFS--- 498

Query: 538 SQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNA 597
                D  V HIKR +IVLK ELGEGAFGKVFLAEC+NL PEQDK+LVAVK LK+AS++A
Sbjct: 499 -----DACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESA 553

Query: 598 RKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAE 657
           R+DF REAELLT LQH+HIV+F+GVC EG PL+MVFEYM+HGDLN+FLR+HGPDA L+A 
Sbjct: 554 RQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAG 613

Query: 658 GNP--PTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSR 715
           G    P  L   Q+L +A Q+AAGMVYLA  HFVHRDLATRNCLVG+ L+VKIGDFGMSR
Sbjct: 614 GEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSR 673

Query: 716 DVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSN 775
           D+YSTDYYRVGG TMLPIRWMPPESI+YRKFTTESDVWS GVVLWEIFTYGKQPWYQLSN
Sbjct: 674 DIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSN 733

Query: 776 NEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLD 835
            E I+CITQGR L+RPR CP EVY +M GCWQREP  R +IK +H  LQ LA+A PVYLD
Sbjct: 734 TEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLD 793

Query: 836 ILG 838
           +LG
Sbjct: 794 VLG 796


>gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isoform
           3 [Homo sapiens]
          Length = 760

 Score =  697 bits (1799), Expect = 0.0
 Identities = 385/774 (49%), Positives = 493/774 (63%), Gaps = 62/774 (8%)

Query: 72  FIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLS 131
           +I NQ+ L+ +   D+     LRNLTIV SGL+FVA  AF     L  +N + N L SLS
Sbjct: 42  YIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLS 101

Query: 132 RKHFRHLDLSELILVGNPFTCSCDIMWIKTLQE-AKSSPDTQDLYCLNESSKNIPLANLQ 190
            K  + L L EL+L GNP  CSC + W++  +E        Q L C  +     PLA++ 
Sbjct: 102 WKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQG----PLAHMP 157

Query: 191 IPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSL 250
             +CG+P+  +  PN +V+ G  + L C V G  +    W +  L        S    SL
Sbjct: 158 NASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSL 217

Query: 251 RIT--NISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVK 308
            +T  N++SD + K ++C AEN VG  + SV + V F P    L +    HHWCIPF+V 
Sbjct: 218 GLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSF-PASVQLHTAVEMHHWCIPFSVD 276

Query: 309 GNPKPALQWFYNGAILNESKYICTKI--HVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNE 366
           G P P+L+W +NG++LNE+ +I T+      N T  HGCL+L+ PTH+NNG+YTL+A N 
Sbjct: 277 GQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANP 336

Query: 367 YGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKT 426
           +G+    I A FM     D+    N  D I +   T+    GD   + +E P   V+   
Sbjct: 337 FGQASASIMAAFM-----DNPFEFNPEDPIPDTNSTS----GDPVEKKDETPF-GVSVAV 386

Query: 427 GREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQGVGPASV 486
           G   L+V+A + ++++       +L L K  R +KFG                 +   +V
Sbjct: 387 G---LAVFACLFLSTL-------LLVLNKCGRRNKFG-----------------INRPAV 419

Query: 487 ISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFV 546
           ++ +D  A  LH ++ G ++ S +EG    +     +  +IENPQYF         D  V
Sbjct: 420 LAPEDGLAMSLHFMTLGGSSLSPTEGKGSGL-----QGHIIENPQYFS--------DACV 466

Query: 547 QHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAE 606
            HIKR +IVLK ELGEGAFGKVFLAEC+NL PEQDK+LVAVK LK+AS++AR+DF REAE
Sbjct: 467 HHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAE 526

Query: 607 LLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNP--PTEL 664
           LLT LQH+HIV+F+GVC EG PL+MVFEYM+HGDLN+FLR+HGPDA L+A G    P  L
Sbjct: 527 LLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPL 586

Query: 665 TQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYR 724
              Q+L +A Q+AAGMVYLA  HFVHRDLATRNCLVG+ L+VKIGDFGMSRD+YSTDYYR
Sbjct: 587 GLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYR 646

Query: 725 VGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQ 784
           VGG TMLPIRWMPPESI+YRKFTTESDVWS GVVLWEIFTYGKQPWYQLSN E I+CITQ
Sbjct: 647 VGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQ 706

Query: 785 GRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 838
           GR L+RPR CP EVY +M GCWQREP  R +IK +H  LQ LA+A PVYLD+LG
Sbjct: 707 GRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 760


>gi|55956794 neurotrophic tyrosine kinase, receptor, type 3 isoform
           c precursor [Homo sapiens]
          Length = 612

 Score =  355 bits (912), Expect = 7e-98
 Identities = 224/580 (38%), Positives = 314/580 (54%), Gaps = 80/580 (13%)

Query: 10  PAMARLW-----GFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP---- 60
           PA    W     G  WL   +  +  ACP +C CS + I C  P  G + FP LE     
Sbjct: 7   PAKCSFWRIFLLGSVWL--DYVGSVLACPANCVCSKTEINCRRPDDGNL-FPLLEGQDSG 63

Query: 61  --------NSVD-PENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAF 111
                   N  D   NIT I I N + L  +N  D+E Y GL+ LTI +SGL+ +  +AF
Sbjct: 64  NSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAF 123

Query: 112 LKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQE-AKSSPD 170
            KN +L++IN + N+LT+LS + F+ L L EL L  N F CSCDI W++  QE  ++  +
Sbjct: 124 AKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLN 183

Query: 171 TQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYW 230
           +Q+LYC+N     +PL  + I  C LP  +++  NLTV EG +  ++C+ +G P+P++ W
Sbjct: 184 SQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDW 243

Query: 231 DVGNLVS-----KHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHF 285
            V  L S      ++N T+    +L + N++S+D+G  ++C+AEN+VG    SV LTV++
Sbjct: 244 IVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYY 303

Query: 286 APTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYH-- 343
            P +  LE P      CI F V+GNP P L W +NG  L ESK I        H EY+  
Sbjct: 304 PPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKII--------HVEYYQE 355

Query: 344 -----GCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYE 398
                GCL  + PTH NNG+YTLIAKN  G   + I+ HF+  P         +P+    
Sbjct: 356 GEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEP---------FPE---- 402

Query: 399 DYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLL--KL 456
                + D     +  +  P   VT K   +   V   V +A+     LLV+LF++  K 
Sbjct: 403 -----STDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAA-FACVLLVVLFVMINKY 456

Query: 457 ARHSKFGMKDFSWFGFGKVKSRQGVGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDA 516
            R SKFGMK                GP +VIS ++DSASPLHHI++G  TPSS + GPD 
Sbjct: 457 GRRSKFGMK----------------GPVAVISGEEDSASPLHHINHGITTPSSLDAGPDT 500

Query: 517 VIIGMTKIPVIENPQYFGITNSQLKPDTFV-QHIKRHNIV 555
           V+IGMT+IPVIENPQYF   ++  KPDT+V  +I  H I+
Sbjct: 501 VVIGMTRIPVIENPQYFRQGHNCHKPDTWVFSNIDNHGIL 540


>gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens]
          Length = 869

 Score =  290 bits (741), Expect = 5e-78
 Identities = 145/303 (47%), Positives = 197/303 (65%), Gaps = 16/303 (5%)

Query: 540 LKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKD-ASDNAR 598
           L P        R+NI   R++GEGAFG+VF A    L P +   +VAVK LK+ AS + +
Sbjct: 561 LNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQ 620

Query: 599 KDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAV----- 653
            DF REA L+    + +IVK  GVC  G P+ ++FEYM +GDLN+FLR+  P  V     
Sbjct: 621 ADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSH 680

Query: 654 --------LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLL 705
                   + + G PP  L+ ++ L IA+Q+AAGM YL+ + FVHRDLATRNCLVGEN++
Sbjct: 681 SDLSMRAQVSSPGPPP--LSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMV 738

Query: 706 VKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTY 765
           VKI DFG+SR++YS DYY+   +  +PIRWMPPESI Y ++TTESDVW+ GVVLWEIF+Y
Sbjct: 739 VKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSY 798

Query: 766 GKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQN 825
           G QP+Y +++ EVI  +  G +L  P  CP E+Y LM  CW + P  R +   IH +L+ 
Sbjct: 799 GLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILER 858

Query: 826 LAK 828
           + +
Sbjct: 859 MCE 861



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 50/172 (29%), Positives = 77/172 (44%), Gaps = 17/172 (9%)

Query: 205 NLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQ-GSLRITNISSDDSGKQ 263
           N+ + EG    L C+  G+P P++ W  G+   +  +  +  + GSLRI N+  +D+G Q
Sbjct: 129 NVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAVLESGSLRIHNVQKEDAG-Q 187

Query: 264 ISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPF-----TVKGNPKPALQWF 318
             CVA+N +G     V + +        L +P S +     F     T  G P P + W 
Sbjct: 188 YRCVAKNSLGTAYSKV-VKLEVEVFARILRAPESHNVTFGSFVTLHCTATGIPVPTITWI 246

Query: 319 YNG-AILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGK 369
            NG A+ + S     K  V +       LQL        G YT IA N++G+
Sbjct: 247 ENGNAVSSGSIQESVKDRVIDSR-----LQL---FITKPGLYTCIATNKHGE 290



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 54/206 (26%), Positives = 82/206 (39%), Gaps = 34/206 (16%)

Query: 183 NIPLANL----------QIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDV 232
           NIPL ++          ++P   + +  L   +  VEE    T  C+V   P P + W  
Sbjct: 6   NIPLVHILTLVAFSGTEKLPKAPVITTPLETVDALVEE--VATFMCAVESYPQPEISWTR 63

Query: 233 GNLVSKHMNET-SHTQGSLRITNISSDDSGKQI-SCVAENLVGEDQDSVN-LTVHFAPTI 289
             ++ K  +   S  +    +T +S +DS   I  C A N VG   +S   L V   P I
Sbjct: 64  NKILIKLFDTRYSIRENGQLLTILSVEDSDDGIYCCTANNGVGGAVESCGALQVKMKPKI 123

Query: 290 T-------FLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEY 342
           T        +E   +     +P T  GNPKP++ W    + L E+  I            
Sbjct: 124 TRPPINVKIIEGLKA----VLPCTTMGNPKPSVSWIKGDSPLRENSRIAVL--------E 171

Query: 343 HGCLQLDNPTHMNNGDYTLIAKNEYG 368
            G L++ N    + G Y  +AKN  G
Sbjct: 172 SGSLRIHNVQKEDAGQYRCVAKNSLG 197


>gi|134152725 receptor tyrosine kinase-like orphan receptor 1
           isoform 1 [Homo sapiens]
          Length = 937

 Score =  254 bits (648), Expect = 3e-67
 Identities = 136/313 (43%), Positives = 187/313 (59%), Gaps = 14/313 (4%)

Query: 525 PVIENPQYFGITNSQL------KPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCP 578
           PV   P++    N ++      KP +  + +    +    ELGE AFGK++    Y   P
Sbjct: 438 PVQRQPKHVRGQNVEMSMLNAYKPKSKAKELPLSAVRFMEELGECAFGKIYKGHLY--LP 495

Query: 579 EQDKI-LVAVKTLKDASDNAR-KDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYM 636
             D   LVA+KTLKD ++  +  +F +EA L+  L H +IV   G   +  P+ M+FEY+
Sbjct: 496 GMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYI 555

Query: 637 KHGDLNKFLRAHGPDAVLMA----EGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRD 692
             GDL++FL    P + +      +G   + L     LHIA QIAAGM YL+S  FVH+D
Sbjct: 556 NQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKD 615

Query: 693 LATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDV 752
           LA RN L+GE L VKI D G+SR++YS DYYRV   ++LPIRWMPPE+IMY KF+++SD+
Sbjct: 616 LAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSDI 675

Query: 753 WSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHM 812
           WS GVVLWEIF++G QP+Y  SN EVIE + + ++L     CP  +Y LM  CW   P  
Sbjct: 676 WSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSR 735

Query: 813 RKNIKGIHTLLQN 825
           R   K IH  L++
Sbjct: 736 RPRFKDIHVRLRS 748



 Score = 35.8 bits (81), Expect = 0.17
 Identities = 28/91 (30%), Positives = 42/91 (46%), Gaps = 6/91 (6%)

Query: 205 NLTVEEGKSITLSCSVAGDPVPNMYWDVGNL----VSKHMNETSHTQGS-LRITNISSDD 259
           N+T   G++  L C V+G+P P + W   +       + ++  S   GS LRI N+ + D
Sbjct: 66  NITTSLGQTAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLDTTD 125

Query: 260 SGKQISCVAENLVGEDQDSVNLTVHFAPTIT 290
           +G    CVA N       +  L V F P  T
Sbjct: 126 TG-YFQCVATNGKEVVSSTGVLFVKFGPPPT 155



 Score = 32.3 bits (72), Expect = 1.9
 Identities = 26/94 (27%), Positives = 41/94 (43%), Gaps = 8/94 (8%)

Query: 307 VKGNPKPALQWFYNGA-ILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKN 365
           V GNP P ++WF N A ++ E + +  +      T Y   L++ N    + G +  +A N
Sbjct: 81  VSGNPPPTIRWFKNDAPVVQEPRRLSFR-----STIYGSRLRIRNLDTTDTGYFQCVATN 135

Query: 366 EYGKDEKQISAHFMGWPGIDDGANPNYPDVIYED 399
             GK+    +       G    A+P Y D   ED
Sbjct: 136 --GKEVVSSTGVLFVKFGPPPTASPGYSDEYEED 167


>gi|62420886 discoidin domain receptor family, member 2 precursor
           [Homo sapiens]
          Length = 855

 Score =  253 bits (647), Expect = 4e-67
 Identities = 148/341 (43%), Positives = 204/341 (59%), Gaps = 27/341 (7%)

Query: 507 PSSSEGGP---DAVIIGMTKIPVIENPQYFGITNSQLK-PDTFVQHIKRHNIVLKRELGE 562
           PS  EG P   +A I+ +  +          +T   L   D  V+   R  +  K +LGE
Sbjct: 512 PSGPEGVPHYAEADIVNLQGVTGGNTYSVPAVTMDLLSGKDVAVEEFPRKLLTFKEKLGE 571

Query: 563 GAFGKVFLAECYNLCPEQDK-----------ILVAVKTLK-DASDNARKDFHREAELLTN 610
           G FG+V L E   +   +DK           +LVAVK L+ DA+ NAR DF +E ++++ 
Sbjct: 572 GQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSR 631

Query: 611 LQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQML 670
           L+  +I+    VC+  DPL M+ EYM++GDLN+FL  H P     +  +    ++ + + 
Sbjct: 632 LKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPN---SSSSDVRTVSYTNLK 688

Query: 671 HIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTM 730
            +A QIA+GM YL+S +FVHRDLATRNCLVG+N  +KI DFGMSR++YS DYYR+ G  +
Sbjct: 689 FMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAV 748

Query: 731 LPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTY-GKQPWYQLSNNEVIECI-----TQ 784
           LPIRWM  ESI+  KFTT SDVW+ GV LWE FT+  +QP+ QLS+ +VIE        Q
Sbjct: 749 LPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQ 808

Query: 785 GR--VLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLL 823
           GR   L +P  CP  VY+LML CW+R+   R + + IH LL
Sbjct: 809 GRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLLL 849


>gi|62420884 discoidin domain receptor family, member 2 precursor
           [Homo sapiens]
          Length = 855

 Score =  253 bits (647), Expect = 4e-67
 Identities = 148/341 (43%), Positives = 204/341 (59%), Gaps = 27/341 (7%)

Query: 507 PSSSEGGP---DAVIIGMTKIPVIENPQYFGITNSQLK-PDTFVQHIKRHNIVLKRELGE 562
           PS  EG P   +A I+ +  +          +T   L   D  V+   R  +  K +LGE
Sbjct: 512 PSGPEGVPHYAEADIVNLQGVTGGNTYSVPAVTMDLLSGKDVAVEEFPRKLLTFKEKLGE 571

Query: 563 GAFGKVFLAECYNLCPEQDK-----------ILVAVKTLK-DASDNARKDFHREAELLTN 610
           G FG+V L E   +   +DK           +LVAVK L+ DA+ NAR DF +E ++++ 
Sbjct: 572 GQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSR 631

Query: 611 LQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQML 670
           L+  +I+    VC+  DPL M+ EYM++GDLN+FL  H P     +  +    ++ + + 
Sbjct: 632 LKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPN---SSSSDVRTVSYTNLK 688

Query: 671 HIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTM 730
            +A QIA+GM YL+S +FVHRDLATRNCLVG+N  +KI DFGMSR++YS DYYR+ G  +
Sbjct: 689 FMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAV 748

Query: 731 LPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTY-GKQPWYQLSNNEVIECI-----TQ 784
           LPIRWM  ESI+  KFTT SDVW+ GV LWE FT+  +QP+ QLS+ +VIE        Q
Sbjct: 749 LPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQ 808

Query: 785 GR--VLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLL 823
           GR   L +P  CP  VY+LML CW+R+   R + + IH LL
Sbjct: 809 GRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLLL 849


>gi|38327632 discoidin domain receptor family, member 1 isoform b
           [Homo sapiens]
          Length = 876

 Score =  247 bits (631), Expect = 3e-65
 Identities = 144/304 (47%), Positives = 189/304 (62%), Gaps = 36/304 (11%)

Query: 551 RHNIVLKRELGEGAFGKVFLAECYNLCPEQDKI--------------LVAVKTLK-DASD 595
           R  +  K +LGEG FG+V L E  +    QD +              LVAVK L+ DA+ 
Sbjct: 570 RSRLRFKEKLGEGQFGEVHLCEVDS---PQDLVSLDFPLNVRKGHPLLVAVKILRPDATK 626

Query: 596 NARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLM 655
           NAR DF +E ++++ L+  +I++  GVCV+ DPL M+ +YM++GDLN+FL AH  +    
Sbjct: 627 NARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKA- 685

Query: 656 AEGNP--------PTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVK 707
           AEG P        PT ++   +LH+A QIA+GM YLA+ +FVHRDLATRNCLVGEN  +K
Sbjct: 686 AEGAPGDGQAAQGPT-ISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIK 744

Query: 708 IGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGK 767
           I DFGMSR++Y+ DYYRV G  +LPIRWM  E I+  KFTT SDVW+ GV LWE+    +
Sbjct: 745 IADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCR 804

Query: 768 -QPWYQLSNNEVIECI-----TQGR--VLQRPRTCPQEVYELMLGCWQREPHMRKNIKGI 819
            QP+ QL++ +VIE        QGR   L RP  CPQ +YELML CW RE   R     +
Sbjct: 805 AQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQL 864

Query: 820 HTLL 823
           H  L
Sbjct: 865 HRFL 868


>gi|83977450 discoidin domain receptor family, member 1 isoform a
           [Homo sapiens]
          Length = 913

 Score =  247 bits (631), Expect = 3e-65
 Identities = 144/304 (47%), Positives = 189/304 (62%), Gaps = 36/304 (11%)

Query: 551 RHNIVLKRELGEGAFGKVFLAECYNLCPEQDKI--------------LVAVKTLK-DASD 595
           R  +  K +LGEG FG+V L E  +    QD +              LVAVK L+ DA+ 
Sbjct: 607 RSRLRFKEKLGEGQFGEVHLCEVDS---PQDLVSLDFPLNVRKGHPLLVAVKILRPDATK 663

Query: 596 NARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLM 655
           NAR DF +E ++++ L+  +I++  GVCV+ DPL M+ +YM++GDLN+FL AH  +    
Sbjct: 664 NARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKA- 722

Query: 656 AEGNP--------PTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVK 707
           AEG P        PT ++   +LH+A QIA+GM YLA+ +FVHRDLATRNCLVGEN  +K
Sbjct: 723 AEGAPGDGQAAQGPT-ISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIK 781

Query: 708 IGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGK 767
           I DFGMSR++Y+ DYYRV G  +LPIRWM  E I+  KFTT SDVW+ GV LWE+    +
Sbjct: 782 IADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCR 841

Query: 768 -QPWYQLSNNEVIECI-----TQGR--VLQRPRTCPQEVYELMLGCWQREPHMRKNIKGI 819
            QP+ QL++ +VIE        QGR   L RP  CPQ +YELML CW RE   R     +
Sbjct: 842 AQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQL 901

Query: 820 HTLL 823
           H  L
Sbjct: 902 HRFL 905


>gi|19743898 receptor tyrosine kinase-like orphan receptor 2
           precursor [Homo sapiens]
          Length = 943

 Score =  246 bits (628), Expect = 6e-65
 Identities = 125/270 (46%), Positives = 169/270 (62%), Gaps = 4/270 (1%)

Query: 559 ELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNA-RKDFHREAELLTNLQHEHIV 617
           ELGE  FGKV+    +   P +    VA+KTLKD ++   R++F  EA L   LQH ++V
Sbjct: 478 ELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVV 537

Query: 618 KFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPT---ELTQSQMLHIAQ 674
              GV  +  PL M+F Y  HGDL++FL    P + + +  +  T    L     +H+  
Sbjct: 538 CLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVA 597

Query: 675 QIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIR 734
           QIAAGM YL+S H VH+DLATRN LV + L VKI D G+ R+VY+ DYY++ G+++LPIR
Sbjct: 598 QIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIR 657

Query: 735 WMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTC 794
           WM PE+IMY KF+ +SD+WS GVVLWE+F+YG QP+   SN +V+E I   +VL  P  C
Sbjct: 658 WMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDC 717

Query: 795 PQEVYELMLGCWQREPHMRKNIKGIHTLLQ 824
           P  VY LM+ CW   P  R   K IH+ L+
Sbjct: 718 PAWVYALMIECWNEFPSRRPRFKDIHSRLR 747



 Score = 39.3 bits (90), Expect = 0.015
 Identities = 30/109 (27%), Positives = 51/109 (46%), Gaps = 9/109 (8%)

Query: 205 NLTVEEGKSITLSCSVAGDPVPNMYW-----DVGNLVSKHMNETSHTQGSLRITNISSDD 259
           N+T+ +G++  L C VAG+P PN+ W      V     + +   +     LRI ++ + D
Sbjct: 70  NITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRLRIQDLDTTD 129

Query: 260 SGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH---WCIPF 305
           +G    CVA N +     +  L V   PT +   +   D+H   +C P+
Sbjct: 130 TG-YYQCVATNGMKTITATGVLFVRLGPTHSPNHNFQDDYHEDGFCQPY 177



 Score = 30.4 bits (67), Expect = 7.1
 Identities = 29/112 (25%), Positives = 46/112 (41%), Gaps = 12/112 (10%)

Query: 289 ITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGA-ILNESKYICTKIHVTNHTEYHGCLQ 347
           IT ++  T+  H      V GNP P ++W  N A ++ E + I     +   TEY   L+
Sbjct: 71  ITIVQGQTAILHC----KVAGNPPPNVRWLKNDAPVVQEPRRI-----IIRKTEYGSRLR 121

Query: 348 LDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYED 399
           + +    + G Y  +A N  G      +       G     N N+ D  +ED
Sbjct: 122 IQDLDTTDTGYYQCVATN--GMKTITATGVLFVRLGPTHSPNHNFQDDYHED 171


>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
            sapiens]
          Length = 1367

 Score =  245 bits (626), Expect = 1e-64
 Identities = 127/289 (43%), Positives = 178/289 (61%), Gaps = 13/289 (4%)

Query: 529  NPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVK 588
            NP+YF   +  + PD +   + R  I + RELG+G+FG V+      +  ++ +  VA+K
Sbjct: 977  NPEYFSAADVYV-PDEW--EVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIK 1033

Query: 589  TLKDASD-NARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRA 647
            T+ +A+    R +F  EA ++      H+V+  GV  +G P +++ E M  GDL  +LR+
Sbjct: 1034 TVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRS 1093

Query: 648  HGPDAVLMAEGNP---PTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENL 704
              P+     E NP   P  L  S+M+ +A +IA GM YL +  FVHRDLA RNC+V E+ 
Sbjct: 1094 LRPEM----ENNPVLAPPSL--SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDF 1147

Query: 705  LVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFT 764
             VKIGDFGM+RD+Y TDYYR GG  +LP+RWM PES+    FTT SDVWS GVVLWEI T
Sbjct: 1148 TVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIAT 1207

Query: 765  YGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMR 813
              +QP+  LSN +V+  + +G +L +P  CP  ++ELM  CWQ  P MR
Sbjct: 1208 LAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMR 1256


>gi|119395738 insulin receptor isoform Short precursor [Homo sapiens]
          Length = 1370

 Score =  244 bits (624), Expect = 2e-64
 Identities = 131/302 (43%), Positives = 182/302 (60%), Gaps = 10/302 (3%)

Query: 529  NPQYFGITN----SQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKIL 584
            NP+Y   ++    S   PD +   + R  I L RELG+G+FG V+     ++   + +  
Sbjct: 984  NPEYLSASDVFPCSVYVPDEW--EVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETR 1041

Query: 585  VAVKTLKD-ASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNK 643
            VAVKT+ + AS   R +F  EA ++      H+V+  GV  +G P ++V E M HGDL  
Sbjct: 1042 VAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKS 1101

Query: 644  FLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGEN 703
            +LR+  P+A     G PP  L   +M+ +A +IA GM YL ++ FVHRDLA RNC+V  +
Sbjct: 1102 YLRSLRPEAE-NNPGRPPPTL--QEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHD 1158

Query: 704  LLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIF 763
              VKIGDFGM+RD+Y TDYYR GG  +LP+RWM PES+    FTT SD+WS GVVLWEI 
Sbjct: 1159 FTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEIT 1218

Query: 764  TYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLL 823
            +  +QP+  LSN +V++ +  G  L +P  CP+ V +LM  CWQ  P MR     I  LL
Sbjct: 1219 SLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL 1278

Query: 824  QN 825
            ++
Sbjct: 1279 KD 1280


>gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]
          Length = 1382

 Score =  244 bits (624), Expect = 2e-64
 Identities = 131/302 (43%), Positives = 182/302 (60%), Gaps = 10/302 (3%)

Query: 529  NPQYFGITN----SQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKIL 584
            NP+Y   ++    S   PD +   + R  I L RELG+G+FG V+     ++   + +  
Sbjct: 996  NPEYLSASDVFPCSVYVPDEW--EVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETR 1053

Query: 585  VAVKTLKD-ASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNK 643
            VAVKT+ + AS   R +F  EA ++      H+V+  GV  +G P ++V E M HGDL  
Sbjct: 1054 VAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKS 1113

Query: 644  FLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGEN 703
            +LR+  P+A     G PP  L   +M+ +A +IA GM YL ++ FVHRDLA RNC+V  +
Sbjct: 1114 YLRSLRPEAE-NNPGRPPPTL--QEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHD 1170

Query: 704  LLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIF 763
              VKIGDFGM+RD+Y TDYYR GG  +LP+RWM PES+    FTT SD+WS GVVLWEI 
Sbjct: 1171 FTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEIT 1230

Query: 764  TYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLL 823
            +  +QP+  LSN +V++ +  G  L +P  CP+ V +LM  CWQ  P MR     I  LL
Sbjct: 1231 SLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL 1290

Query: 824  QN 825
            ++
Sbjct: 1291 KD 1292


>gi|83977452 discoidin domain receptor family, member 1 isoform c
           [Homo sapiens]
          Length = 919

 Score =  241 bits (614), Expect = 3e-63
 Identities = 144/310 (46%), Positives = 189/310 (60%), Gaps = 42/310 (13%)

Query: 551 RHNIVLKRELGEGAFGKVFLAECYNLCPEQDKI--------------LVAVKTLK-DASD 595
           R  +  K +LGEG FG+V L E  +    QD +              LVAVK L+ DA+ 
Sbjct: 607 RSRLRFKEKLGEGQFGEVHLCEVDS---PQDLVSLDFPLNVRKGHPLLVAVKILRPDATK 663

Query: 596 NA------RKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHG 649
           NA      R DF +E ++++ L+  +I++  GVCV+ DPL M+ +YM++GDLN+FL AH 
Sbjct: 664 NASFSLFSRNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQ 723

Query: 650 PDAVLMAEGNP--------PTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVG 701
            +    AEG P        PT ++   +LH+A QIA+GM YLA+ +FVHRDLATRNCLVG
Sbjct: 724 LEDKA-AEGAPGDGQAAQGPT-ISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVG 781

Query: 702 ENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWE 761
           EN  +KI DFGMSR++Y+ DYYRV G  +LPIRWM  E I+  KFTT SDVW+ GV LWE
Sbjct: 782 ENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWE 841

Query: 762 IFTYGK-QPWYQLSNNEVIECI-----TQGR--VLQRPRTCPQEVYELMLGCWQREPHMR 813
           +    + QP+ QL++ +VIE        QGR   L RP  CPQ +YELML CW RE   R
Sbjct: 842 VLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQR 901

Query: 814 KNIKGIHTLL 823
                +H  L
Sbjct: 902 PPFSQLHRFL 911


>gi|31657140 insulin receptor-related receptor precursor [Homo
            sapiens]
          Length = 1297

 Score =  238 bits (607), Expect = 2e-62
 Identities = 129/304 (42%), Positives = 183/304 (60%), Gaps = 9/304 (2%)

Query: 529  NPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVK 588
            NP+YF  ++  + PD +   + R  I + RELG+G+FG V+      L   ++   VA+K
Sbjct: 957  NPEYFSASDMYV-PDEW--EVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALK 1013

Query: 589  TLKD-ASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRA 647
            T+ + AS     +F +EA ++   +  H+V+  GV  +G P +++ E M  GDL   LR+
Sbjct: 1014 TVNELASPRECIEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRS 1073

Query: 648  HGPDAVLMAEGNPPT-ELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLV 706
              P+A    E NP   +    +M+ +A +IA GM YLA+  FVHRDLA RNC+V ++  V
Sbjct: 1074 LRPEA----ENNPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTV 1129

Query: 707  KIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYG 766
            KIGDFGM+RDVY TDYYR GG  +LP+RWM PES+    FTT SDVWS GVVLWEI T  
Sbjct: 1130 KIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLA 1189

Query: 767  KQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNL 826
            +QP+  LSN +V++ +  G VL+    CP ++ ELM  CWQ  P +R +   I   +Q  
Sbjct: 1190 EQPYQGLSNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQEE 1249

Query: 827  AKAS 830
             + S
Sbjct: 1250 LRPS 1253


>gi|29029632 anaplastic lymphoma kinase [Homo sapiens]
          Length = 1620

 Score =  231 bits (589), Expect = 2e-60
 Identities = 116/274 (42%), Positives = 163/274 (59%), Gaps = 10/274 (3%)

Query: 546  VQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDA-SDNARKDFHRE 604
            ++ + R NI L R LG GAFG+V+  +   +  +   + VAVKTL +  S+    DF  E
Sbjct: 1108 LKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLME 1167

Query: 605  AELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTEL 664
            A +++   H++IV+  GV ++  P  ++ E M  GDL  FLR   P        + P+ L
Sbjct: 1168 ALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRP------RPSQPSSL 1221

Query: 665  TQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLV---GENLLVKIGDFGMSRDVYSTD 721
                +LH+A+ IA G  YL   HF+HRD+A RNCL+   G   + KIGDFGM+RD+Y   
Sbjct: 1222 AMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRAS 1281

Query: 722  YYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIEC 781
            YYR GG  MLP++WMPPE+ M   FT+++D WS GV+LWEIF+ G  P+   SN EV+E 
Sbjct: 1282 YYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEF 1341

Query: 782  ITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKN 815
            +T G  +  P+ CP  VY +M  CWQ +P  R N
Sbjct: 1342 VTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPN 1375


>gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [Homo
            sapiens]
          Length = 1070

 Score =  224 bits (571), Expect = 3e-58
 Identities = 178/628 (28%), Positives = 284/628 (45%), Gaps = 84/628 (13%)

Query: 204  PNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQ 263
            P   +E  K  T+ CS  G   P + W+  +  S     T +  G+L    ++ DD+G  
Sbjct: 510  PQQCMEFDKEATVPCSATGREKPTIKWERADGSSLPEWVTDNA-GTLHFARVTRDDAGNY 568

Query: 264  ISCVAEN-LVGEDQDSVNLTVHFAPTITFLESPT-----SDHHWCIPFTVKGNPKPALQW 317
             +C+A N   G+ +  V LTV  A  ITF   P        H   +    +G+PKP +QW
Sbjct: 569  -TCIASNGPQGQIRAHVQLTV--AVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW 625

Query: 318  FYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAH 377
                 IL+      TK+    H   +G L + +    ++G YT IA N       +   +
Sbjct: 626  KGKDRILDP-----TKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLY 680

Query: 378  FMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVV 437
             +  P  ++   P  P   Y+   T    +G                          AV 
Sbjct: 681  VVDKPVPEESEGPGSPPP-YKMIQTIGLSVGA-------------------------AVA 714

Query: 438  VIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQGVGPASVISNDDDSASPL 497
             I +V+G    +M +  K  +  +              K  +G  P     N      PL
Sbjct: 715  YIIAVLG----LMFYCKKRCKAKRLQ------------KQPEGEEPEMECLN----GGPL 754

Query: 498  HHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLK 557
                   N   S+E   +  +  +   P   N ++   T+ ++       H  R ++   
Sbjct: 755  Q------NGQPSAEIQEEVALTSLGSGPAATNKRHS--TSDKM-------HFPRSSLQPI 799

Query: 558  RELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIV 617
              LG+  FG+VFLA+   L     + LV VK+L+   +  + DF RE E+   L H ++V
Sbjct: 800  TTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVV 859

Query: 618  KFYGVCVEGDPLIMVFEYMKHGDLNKFLR-AHGPDAVLMAEGNPPTELTQSQMLHIAQQI 676
            +  G+C E +P  MV EY+  GDL +FLR +   D  L ++      L+  Q + +  Q+
Sbjct: 860  RLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ-----PLSTKQKVALCTQV 914

Query: 677  AAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWM 736
            A GM +L++  FVH+DLA RNCLV     VK+   G+S+DVY+++YY       +P+RWM
Sbjct: 915  ALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHF-RQAWVPLRWM 973

Query: 737  PPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRV-LQRPRTCP 795
             PE+I+   F+T+SDVW+ GV++WE+FT+G+ P    +++EV+  +  G+  L +P  CP
Sbjct: 974  SPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCP 1033

Query: 796  QEVYELMLGCWQREPHMRKNIKGIHTLL 823
             ++Y LM  CW   P  R +   I + L
Sbjct: 1034 SKLYRLMQRCWALSPKDRPSFSEIASAL 1061



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 45/176 (25%), Positives = 67/176 (38%), Gaps = 21/176 (11%)

Query: 208 VEEGKSITLSCSVAGDPVPNMYWDVGN-LVSKHMNETSHTQGSLRITNISSDDSGKQISC 266
           +EEGK   L C     P P + W     L+S+         G+LRI ++   D G    C
Sbjct: 423 LEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYD-GTWYRC 481

Query: 267 VAENLVGEDQDSVNLTV----HFAPTITFLESPTSDHHWCIPFTVKGNPKPALQW-FYNG 321
           ++    G  +    + V     F P     +    D    +P +  G  KP ++W   +G
Sbjct: 482 MSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERADG 541

Query: 322 AILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAH 377
           + L E             T+  G L     T  + G+YT IA N     + QI AH
Sbjct: 542 SSLPEWV-----------TDNAGTLHFARVTRDDAGNYTCIASN---GPQGQIRAH 583



 Score = 37.4 bits (85), Expect = 0.058
 Identities = 36/172 (20%), Positives = 68/172 (39%), Gaps = 20/172 (11%)

Query: 210 EGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVA- 268
           +G+   L C V      ++YW +     +          SL    +          CVA 
Sbjct: 45  QGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVAR 104

Query: 269 ENLVGEDQDSVNLT-----VHFAPTITFLESPTSDHHW------CIPFTVKGNPKPALQW 317
           +++ GE+  S N +     +   P +  L+ P S+          +   + G+P+P  QW
Sbjct: 105 DDVTGEEARSANASFNIKWIEAGPVV--LKHPASEAEIQPQTQVTLRCHIDGHPRPTYQW 162

Query: 318 FYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGK 369
           F +G  L++ +      H  +  E +  L+   P H  +G Y+  A + +G+
Sbjct: 163 FRDGTPLSDGQ----SNHTVSSKERNLTLRPAGPEH--SGLYSCCAHSAFGQ 208



 Score = 33.5 bits (75), Expect = 0.84
 Identities = 44/179 (24%), Positives = 66/179 (36%), Gaps = 18/179 (10%)

Query: 203 APNLTVEEGKSITLSCSVAGDPVPNMYW--DVGNLVSKHMNET-SHTQGSLRITNISSDD 259
           A    ++    +TL C + G P P   W  D   L     N T S  + +L +     + 
Sbjct: 135 ASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEH 194

Query: 260 SGKQISCVAENLVGEDQDSVNLTV-----HFAPTITFLESPTSDHHWCIPF--TVKGNPK 312
           SG   SC A +  G+   S N T+      FA  +   +      +    F       P 
Sbjct: 195 SG-LYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPP 253

Query: 313 PALQWFYNG--AILNESKYICTKIHVTNHTEY-HGCLQLDNPTHMNNGDYTLIAKNEYG 368
           P+LQW +     I N S+      H+   T + +G L L      N G Y  I + + G
Sbjct: 254 PSLQWLFEDETPITNRSR----PPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRG 308


>gi|254028242 fibroblast growth factor receptor 3 isoform 3
           precursor [Homo sapiens]
          Length = 808

 Score =  220 bits (560), Expect = 5e-57
 Identities = 183/662 (27%), Positives = 302/662 (45%), Gaps = 91/662 (13%)

Query: 206 LTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETS-----HTQGSLRITNISSDDS 260
           L V    ++   C  AG+P P++ W       +  +        H Q SL + ++   D 
Sbjct: 164 LAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDR 223

Query: 261 GKQISCVAENLVGEDQDSVNLTV-HFAPTITFLESPTSDHHWCIPFT-------VKGNPK 312
           G   +CV EN  G  + +  L V   +P    L++    +   +  +       V  + +
Sbjct: 224 GNY-TCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQ 282

Query: 313 PALQWFYNGAILNESK-------YICT-KIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAK 364
           P +QW  +  + N SK       Y+   K  ++   E    L+L N +  + G+Y   A 
Sbjct: 283 PHIQWLKHVEV-NGSKVGPDGTPYVTVLKSWISESVEADVRLRLANVSERDGGEYLCRAT 341

Query: 365 NEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTD 424
           N  G  EK        W  +               +G  A +         E+   D   
Sbjct: 342 NFIGVAEKAF------WLSV---------------HGPRAAE--------EELVEAD--- 369

Query: 425 KTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQGVGPA 484
               E  SVYA ++   V  F  ++++  + L R               +   ++G+G  
Sbjct: 370 ----EAGSVYAGILSYGVGFFLFILVVAAVTLCRL--------------RSPPKKGLGSP 411

Query: 485 SVISNDDDSASPL-HHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPD 543
           +V      S  PL   +S  SN   SS    +  ++ + ++   E P    ++  +L  D
Sbjct: 412 TV---HKISRFPLKRQVSLESNASMSS----NTPLVRIARLSSGEGPTLANVSELELPAD 464

Query: 544 TFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQ--DKILVAVKTLKD-ASDNARKD 600
              + + R  + L + LGEG FG+V +AE   +  ++    + VAVK LKD A+D    D
Sbjct: 465 PKWE-LSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSD 523

Query: 601 FHREAELLTNL-QHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGN 659
              E E++  + +H++I+   G C +G PL ++ EY   G+L +FLRA  P  +  +   
Sbjct: 524 LVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDT 583

Query: 660 ---PPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRD 716
              P  +LT   ++  A Q+A GM YLASQ  +HRDLA RN LV E+ ++KI DFG++RD
Sbjct: 584 CKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARD 643

Query: 717 VYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNN 776
           V++ DYY+   +  LP++WM PE++  R +T +SDVWS GV+LWEIFT G  P+  +   
Sbjct: 644 VHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVE 703

Query: 777 EVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNL--AKASPVYL 834
           E+ + + +G  + +P  C  ++Y +M  CW   P  R   K +   L  +    ++  YL
Sbjct: 704 ELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYL 763

Query: 835 DI 836
           D+
Sbjct: 764 DL 765



 Score = 34.3 bits (77), Expect = 0.49
 Identities = 28/110 (25%), Positives = 45/110 (40%), Gaps = 23/110 (20%)

Query: 191 IPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYW---------DVG-------N 234
           I   GLP+      N T   G  +   C V  D  P++ W          VG        
Sbjct: 254 ILQAGLPA------NQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVT 307

Query: 235 LVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVH 284
           ++   ++E+      LR+ N+S  D G+ + C A N +G  + +  L+VH
Sbjct: 308 VLKSWISESVEADVRLRLANVSERDGGEYL-CRATNFIGVAEKAFWLSVH 356


>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
           [Homo sapiens]
          Length = 806

 Score =  219 bits (559), Expect = 6e-57
 Identities = 183/663 (27%), Positives = 302/663 (45%), Gaps = 95/663 (14%)

Query: 206 LTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETS-----HTQGSLRITNISSDDS 260
           L V    ++   C  AG+P P++ W       +  +        H Q SL + ++   D 
Sbjct: 164 LAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDR 223

Query: 261 GKQISCVAENLVGEDQDSVNLTV-HFAPTITFLESPTSDHHWCIPFT-------VKGNPK 312
           G   +CV EN  G  + +  L V   +P    L++    +   +  +       V  + +
Sbjct: 224 GNY-TCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQ 282

Query: 313 PALQWFYNGAILNESK-------YICT-KIHVTNHTEYH-GCLQLDNPTHMNNGDYTLIA 363
           P +QW  +  + N SK       Y+   K    N T+     L L N T  + G+YT +A
Sbjct: 283 PHIQWLKHVEV-NGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLA 341

Query: 364 KNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVT 423
            N  G       +H   W  +          +  E+    A++ G               
Sbjct: 342 GNSIG------FSHHSAWLVV----------LPAEEELVEADEAG--------------- 370

Query: 424 DKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQGVGP 483
                   SVYA ++   V  F  ++++  + L R               +   ++G+G 
Sbjct: 371 --------SVYAGILSYGVGFFLFILVVAAVTLCRL--------------RSPPKKGLGS 408

Query: 484 ASVISNDDDSASPL-HHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKP 542
            +V      S  PL   +S  SN   SS    +  ++ + ++   E P    ++  +L  
Sbjct: 409 PTV---HKISRFPLKRQVSLESNASMSS----NTPLVRIARLSSGEGPTLANVSELELPA 461

Query: 543 DTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQ--DKILVAVKTLKD-ASDNARK 599
           D   + + R  + L + LGEG FG+V +AE   +  ++    + VAVK LKD A+D    
Sbjct: 462 DPKWE-LSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLS 520

Query: 600 DFHREAELLTNL-QHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEG 658
           D   E E++  + +H++I+   G C +G PL ++ EY   G+L +FLRA  P  +  +  
Sbjct: 521 DLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFD 580

Query: 659 N---PPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSR 715
               P  +LT   ++  A Q+A GM YLASQ  +HRDLA RN LV E+ ++KI DFG++R
Sbjct: 581 TCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLAR 640

Query: 716 DVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSN 775
           DV++ DYY+   +  LP++WM PE++  R +T +SDVWS GV+LWEIFT G  P+  +  
Sbjct: 641 DVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPV 700

Query: 776 NEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNL--AKASPVY 833
            E+ + + +G  + +P  C  ++Y +M  CW   P  R   K +   L  +    ++  Y
Sbjct: 701 EELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEY 760

Query: 834 LDI 836
           LD+
Sbjct: 761 LDL 763


>gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precursor
           [Homo sapiens]
          Length = 864

 Score =  218 bits (554), Expect = 2e-56
 Identities = 111/283 (39%), Positives = 161/283 (56%), Gaps = 10/283 (3%)

Query: 546 VQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKD-ASDNARKDFHRE 604
           V  +   N+ L R LG GAFG+V+      L  +   + VA+KTL +  S     DF  E
Sbjct: 502 VTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLME 561

Query: 605 AELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTEL 664
           A +++  +H++IV+  G+ +   P +++ E M  GD+  FLR   P          P+ L
Sbjct: 562 ALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHL------GQPSPL 615

Query: 665 TQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLV---GENLLVKIGDFGMSRDVYSTD 721
               +L +AQ IA G  YL   HF+HRD+A RNCL+   G + + KIGDFGM+RD+Y   
Sbjct: 616 VMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRAS 675

Query: 722 YYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIEC 781
           YYR G   +LP++WMPPE+ +   FT+++D WS GV+LWEIF+ G  P+   +N EV++ 
Sbjct: 676 YYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDF 735

Query: 782 ITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQ 824
           +  G  +  PR CP  VY +M  CWQ EP +R +   I   LQ
Sbjct: 736 VVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQ 778


>gi|46249416 leukocyte receptor tyrosine kinase isoform 2 precursor
           [Homo sapiens]
          Length = 803

 Score =  218 bits (554), Expect = 2e-56
 Identities = 111/283 (39%), Positives = 161/283 (56%), Gaps = 10/283 (3%)

Query: 546 VQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKD-ASDNARKDFHRE 604
           V  +   N+ L R LG GAFG+V+      L  +   + VA+KTL +  S     DF  E
Sbjct: 441 VTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLME 500

Query: 605 AELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTEL 664
           A +++  +H++IV+  G+ +   P +++ E M  GD+  FLR   P          P+ L
Sbjct: 501 ALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHL------GQPSPL 554

Query: 665 TQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLV---GENLLVKIGDFGMSRDVYSTD 721
               +L +AQ IA G  YL   HF+HRD+A RNCL+   G + + KIGDFGM+RD+Y   
Sbjct: 555 VMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRAS 614

Query: 722 YYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIEC 781
           YYR G   +LP++WMPPE+ +   FT+++D WS GV+LWEIF+ G  P+   +N EV++ 
Sbjct: 615 YYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDF 674

Query: 782 ITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQ 824
           +  G  +  PR CP  VY +M  CWQ EP +R +   I   LQ
Sbjct: 675 VVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQ 717


>gi|222144233 fibroblast growth factor receptor 2 isoform 4
           precursor [Homo sapiens]
          Length = 709

 Score =  214 bits (545), Expect = 3e-55
 Identities = 154/518 (29%), Positives = 244/518 (47%), Gaps = 70/518 (13%)

Query: 309 GNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYG 368
           GNP P ++W  NG    +   I     V N    H  L +++    + G+YT + +NEYG
Sbjct: 183 GNPMPTMRWLKNGKEFKQEHRI-GGYKVRNQ---HWSLIMESVVPSDKGNYTCVVENEYG 238

Query: 369 KDEKQISAHFMGWPGIDDGANPNYP-DVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTG 427
                               N  Y  DV+                R  EI ++       
Sbjct: 239 S------------------INHTYHLDVV-------------APGREKEITASP------ 261

Query: 428 REHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWF-GFGKVKSRQGVGPASV 486
            ++L + A+  I   +  C++V + L ++   +K    DFS      K+  R  +     
Sbjct: 262 -DYLEI-AIYCIGVFLIACMVVTVILCRMKNTTK--KPDFSSQPAVHKLTKRIPLRRQVT 317

Query: 487 ISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFV 546
           +S +  S       S  SNTP         V I        + P   G++  +L P+   
Sbjct: 318 VSAESSS-------SMNSNTP--------LVRITTRLSSTADTPMLAGVSEYEL-PEDPK 361

Query: 547 QHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDK--ILVAVKTLKD-ASDNARKDFHR 603
               R  + L + LGEG FG+V +AE   +  ++ K  + VAVK LKD A++    D   
Sbjct: 362 WEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVS 421

Query: 604 EAELLTNL-QHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMA---EGN 659
           E E++  + +H++I+   G C +  PL ++ EY   G+L ++LRA  P  +  +      
Sbjct: 422 EMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRV 481

Query: 660 PPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYS 719
           P  ++T   ++    Q+A GM YLASQ  +HRDLA RN LV EN ++KI DFG++RD+ +
Sbjct: 482 PEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINN 541

Query: 720 TDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVI 779
            DYY+   +  LP++WM PE++  R +T +SDVWS GV++WEIFT G  P+  +   E+ 
Sbjct: 542 IDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELF 601

Query: 780 ECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIK 817
           + + +G  + +P  C  E+Y +M  CW   P  R   K
Sbjct: 602 KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFK 639


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.136    0.425 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,085,982
Number of Sequences: 37866
Number of extensions: 1575489
Number of successful extensions: 7995
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 601
Number of HSP's successfully gapped in prelim test: 447
Number of HSP's that attempted gapping in prelim test: 3766
Number of HSP's gapped (non-prelim): 2619
length of query: 838
length of database: 18,247,518
effective HSP length: 111
effective length of query: 727
effective length of database: 14,044,392
effective search space: 10210272984
effective search space used: 10210272984
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.