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Search of human proteins with 21264324
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21264324 trace amine associated receptor 1 [Homo sapiens]
(339 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21264324 trace amine associated receptor 1 [Homo sapiens] 700 0.0
gi|74275344 trace amine associated receptor 2 isoform 1 [Homo sa... 327 9e-90
gi|74275342 trace amine associated receptor 2 isoform 2 [Homo sa... 315 4e-86
gi|110618256 trace amine associated receptor 9 [Homo sapiens] 289 2e-78
gi|28173558 trace amine associated receptor 6 [Homo sapiens] 278 4e-75
gi|16751917 trace amine associated receptor 8 [Homo sapiens] 271 5e-73
gi|223633986 trace amine associated receptor 5 [Homo sapiens] 260 1e-69
gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens] 204 9e-53
gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens] 204 9e-53
gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens] 204 9e-53
gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens] 204 9e-53
gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens] 204 9e-53
gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens] 204 9e-53
gi|94421458 serotonin 5-HT4 receptor isoform hb [Homo sapiens] 201 1e-51
gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens] 180 2e-45
gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens] 180 2e-45
gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sap... 172 5e-43
gi|4503383 dopamine receptor D1 [Homo sapiens] 170 1e-42
gi|4503391 dopamine receptor D5 [Homo sapiens] 169 3e-42
gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens] 167 2e-41
gi|4557265 beta-1-adrenergic receptor [Homo sapiens] 160 1e-39
gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens] 154 1e-37
gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens] 154 1e-37
gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens] 154 1e-37
gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens] 154 1e-37
gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens] 154 1e-37
gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens] 154 1e-37
gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens] 154 1e-37
gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo sa... 153 2e-37
gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo sapi... 150 2e-36
>gi|21264324 trace amine associated receptor 1 [Homo sapiens]
Length = 339
Score = 700 bits (1806), Expect = 0.0
Identities = 339/339 (100%), Positives = 339/339 (100%)
Query: 1 MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNW 60
MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNW
Sbjct: 1 MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNW 60
Query: 61 LIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISID 120
LIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISID
Sbjct: 61 LIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISID 120
Query: 121 RYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRG 180
RYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRG
Sbjct: 121 RYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRG 180
Query: 181 GCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDANQKLQIGLEMKNG 240
GCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDANQKLQIGLEMKNG
Sbjct: 181 GCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDANQKLQIGLEMKNG 240
Query: 241 ISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLIWFGYLNSTFN 300
ISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLIWFGYLNSTFN
Sbjct: 241 ISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLIWFGYLNSTFN 300
Query: 301 PMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLELSS 339
PMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLELSS
Sbjct: 301 PMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLELSS 339
>gi|74275344 trace amine associated receptor 2 isoform 1 [Homo
sapiens]
Length = 351
Score = 327 bits (838), Expect = 9e-90
Identities = 163/322 (50%), Positives = 213/322 (66%), Gaps = 13/322 (4%)
Query: 5 CHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNWLIHS 64
C N SC +N S VR ++YS M I T+ GNL +I+SIS+FKQLHTPTN+LI S
Sbjct: 25 CSEYGNRSCPENERSLGVRVAMYSFMAGSIFITIFGNLAMIISISYFKQLHTPTNFLILS 84
Query: 65 MATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYA 124
MA DFLLG +MPYSM+RS E+CWYFG FCKI+ S D+MLS SIFHL ++IDR+YA
Sbjct: 85 MAITDFLLGFTIMPYSMIRSVENCWYFGLTFCKIYYSFDLMLSITSIFHLCSVAIDRFYA 144
Query: 125 VCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRGGCSV 184
+C PL Y K+ I VI ++ + WSVP FAFG++F E G E Y V C C V
Sbjct: 145 ICYPLLYSTKITIPVIKRLLLLCWSVPGAFAFGVVFSEAYADGIEG-YDILVACSSSCPV 203
Query: 185 FFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISD--ANQKLQIGLEMKNGIS 242
F+K+ G FM F+ PGS+M+ +Y +I+ ++++ A I++ NQ Q+
Sbjct: 204 MFNKLWGTTLFMAGFFTPGSMMVGIYGKIFAVSRKHAHAINNLRENQNNQV--------- 254
Query: 243 QSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLIWFGYLNSTFNPM 302
K++KA KTLGIV+GVFL+CW P F ++DPFL++ P L D L WFGY NST NP+
Sbjct: 255 -KKDKKAAKTLGIVIGVFLLCWFPCFFTILLDPFLNFSTPVVLFDALTWFGYFNSTCNPL 313
Query: 303 VYAFFYPWFRKALKMMLFGKIF 324
+Y FFYPWFR+ALK +L GKIF
Sbjct: 314 IYGFFYPWFRRALKYILLGKIF 335
>gi|74275342 trace amine associated receptor 2 isoform 2 [Homo
sapiens]
Length = 306
Score = 315 bits (807), Expect = 4e-86
Identities = 155/301 (51%), Positives = 203/301 (67%), Gaps = 13/301 (4%)
Query: 26 LYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNWLIHSMATVDFLLGCLVMPYSMVRSA 85
+YS M I T+ GNL +I+SIS+FKQLHTPTN+LI SMA DFLLG +MPYSM+RS
Sbjct: 1 MYSFMAGSIFITIFGNLAMIISISYFKQLHTPTNFLILSMAITDFLLGFTIMPYSMIRSV 60
Query: 86 EHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVCDPLRYKAKMNILVICVMIF 145
E+CWYFG FCKI+ S D+MLS SIFHL ++IDR+YA+C PL Y K+ I VI ++
Sbjct: 61 ENCWYFGLTFCKIYYSFDLMLSITSIFHLCSVAIDRFYAICYPLLYSTKITIPVIKRLLL 120
Query: 146 ISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRGGCSVFFSKISGVLTFMTSFYIPGSI 205
+ WSVP FAFG++F E G E Y V C C V F+K+ G FM F+ PGS+
Sbjct: 121 LCWSVPGAFAFGVVFSEAYADGIEG-YDILVACSSSCPVMFNKLWGTTLFMAGFFTPGSM 179
Query: 206 MLCVYYRIYLIAKEQARLISD--ANQKLQIGLEMKNGISQSKERKAVKTLGIVMGVFLIC 263
M+ +Y +I+ ++++ A I++ NQ Q+ K++KA KTLGIV+GVFL+C
Sbjct: 180 MVGIYGKIFAVSRKHAHAINNLRENQNNQV----------KKDKKAAKTLGIVIGVFLLC 229
Query: 264 WCPFFICTVMDPFLHYIIPPTLNDVLIWFGYLNSTFNPMVYAFFYPWFRKALKMMLFGKI 323
W P F ++DPFL++ P L D L WFGY NST NP++Y FFYPWFR+ALK +L GKI
Sbjct: 230 WFPCFFTILLDPFLNFSTPVVLFDALTWFGYFNSTCNPLIYGFFYPWFRRALKYILLGKI 289
Query: 324 F 324
F
Sbjct: 290 F 290
>gi|110618256 trace amine associated receptor 9 [Homo sapiens]
Length = 348
Score = 289 bits (740), Expect = 2e-78
Identities = 141/332 (42%), Positives = 204/332 (61%), Gaps = 2/332 (0%)
Query: 5 CHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNWLIHS 64
C+ +N SC+K +S R+ LY+++ + GNL+V+++I HFKQLHTPTN+LI S
Sbjct: 14 CYKNVNESCIKTPYSPGPRSILYAVLGFGAVLAAFGNLLVMIAILHFKQLHTPTNFLIAS 73
Query: 65 MATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYA 124
+A DFL+G VMP+S VRS E CWYFG+ +CK HT D AS+FHL IS+DRY A
Sbjct: 74 LACADFLVGVTVMPFSTVRSVESCWYFGDSYCKFHTCFDTSFCFASLFHLCCISVDRYIA 133
Query: 125 VCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRGGCSV 184
V DPL Y K + V + I +SW ++F + + N +G EE+ + C GGC
Sbjct: 134 VTDPLTYPTKFTVSVSGICIVLSWFFSVTYSFSIFYTGANEEGIEELVVA-LTCVGGCQA 192
Query: 185 FFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDANQKLQIGLEMKNGISQS 244
++ +L F+ F+IP M+ +Y +I+L+AK QAR I + Q E
Sbjct: 193 PLNQNWVLLCFLL-FFIPNVAMVFIYSKIFLVAKHQARKIESTASQAQSSSESYKERVAK 251
Query: 245 KERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLIWFGYLNSTFNPMVY 304
+ERKA KTLGI M FL+ W P+ + V+D ++++I PP + ++L+W Y NS NP++Y
Sbjct: 252 RERKAAKTLGIAMAAFLVSWLPYLVDAVIDAYMNFITPPYVYEILVWCVYYNSAMNPLIY 311
Query: 305 AFFYPWFRKALKMMLFGKIFQKDSSRCKLFLE 336
AFFY WF KA+K+++ GK+ + DSS LF E
Sbjct: 312 AFFYQWFGKAIKLIVSGKVLRTDSSTTNLFSE 343
>gi|28173558 trace amine associated receptor 6 [Homo sapiens]
Length = 345
Score = 278 bits (712), Expect = 4e-75
Identities = 137/332 (41%), Positives = 204/332 (61%), Gaps = 2/332 (0%)
Query: 5 CHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNWLIHS 64
C+ +N SCVK +S R LY + + + GNL+V++SI HFKQLH+PTN+L+ S
Sbjct: 14 CYANVNGSCVKIPFSPGSRVILYIVFGFGAVLAVFGNLLVMISILHFKQLHSPTNFLVAS 73
Query: 65 MATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYA 124
+A DFL+G VMP+SMVR+ E CWYFG FC HT D+ +S+FHL FISIDRY A
Sbjct: 74 LACADFLVGVTVMPFSMVRTVESCWYFGRSFCTFHTCCDVAFCYSSLFHLCFISIDRYIA 133
Query: 125 VCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRGGCSV 184
V DPL Y K + V + I +SW +P +++ + + + G EE+ ++C GGC
Sbjct: 134 VTDPLVYPTKFTVSVSGICISVSWILPLMYSGAVFYTGVYDDGLEEL-SDALNCIGGCQT 192
Query: 185 FFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDANQKLQIGLEMKNGISQS 244
++ + VLT SF+IP IM+ +Y I+L+A+ QA+ I + K + E
Sbjct: 193 VVNQ-NWVLTDFLSFFIPTFIMIILYGNIFLVARRQAKKIENTGSKTESSSESYKARVAR 251
Query: 245 KERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLIWFGYLNSTFNPMVY 304
+ERKA KTLG+ + F+I W P+ I +++D F+ +I P + ++ W Y NS NP++Y
Sbjct: 252 RERKAAKTLGVTVVAFMISWLPYSIDSLIDAFMGFITPACIYEICCWCAYYNSAMNPLIY 311
Query: 305 AFFYPWFRKALKMMLFGKIFQKDSSRCKLFLE 336
A FYPWFRKA+K+++ G++ + S+ LF E
Sbjct: 312 ALFYPWFRKAIKVIVTGQVLKNSSATMNLFSE 343
>gi|16751917 trace amine associated receptor 8 [Homo sapiens]
Length = 342
Score = 271 bits (694), Expect = 5e-73
Identities = 133/336 (39%), Positives = 201/336 (59%), Gaps = 2/336 (0%)
Query: 1 MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNW 60
++ C+ +N SC++ +S R LY+ L + GNL+V+ S+ HFKQLH+PTN+
Sbjct: 9 VVQLCYEDVNGSCIETPYSPGSRVILYTAFSFGSLLAVFGNLLVMTSVLHFKQLHSPTNF 68
Query: 61 LIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISID 120
LI S+A DFL+G VM +SMVR+ E CWYFG FC +H+ D+ +S+ HL FI ID
Sbjct: 69 LIASLACADFLVGVTVMLFSMVRTVESCWYFGAKFCTLHSCCDVAFCYSSVLHLCFICID 128
Query: 121 RYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRG 180
RY V DPL Y K + V + I +SW +P ++ + + +N G EE+ ++C G
Sbjct: 129 RYIVVTDPLVYATKFTVSVSGICISVSWILPLTYSGAVFYTGVNDDGLEEL-VSALNCVG 187
Query: 181 GCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDANQKLQIGLEMKNG 240
GC + S+ VL F+IP +M+ +Y +I+LIAK+QA I + K++ E
Sbjct: 188 GCQIIVSQ-GWVLIDFLLFFIPTLVMIILYSKIFLIAKQQAIKIETTSSKVESSSESYKI 246
Query: 241 ISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLIWFGYLNSTFN 300
+ERKA KTLG+ + F+I W P+ + ++D F+ ++ P + ++ W Y NS N
Sbjct: 247 RVAKRERKAAKTLGVTVLAFVISWLPYTVDILIDAFMGFLTPAYIYEICCWSAYYNSAMN 306
Query: 301 PMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLE 336
P++YA FYPWFRKA+K++L G + + SS LFLE
Sbjct: 307 PLIYALFYPWFRKAIKLILSGDVLKASSSTISLFLE 342
>gi|223633986 trace amine associated receptor 5 [Homo sapiens]
Length = 337
Score = 260 bits (664), Expect = 1e-69
Identities = 129/333 (38%), Positives = 196/333 (58%), Gaps = 11/333 (3%)
Query: 4 FCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNWLIH 63
FC+ + N SC + + ++ +Y +L ++GN+ V ++S+FK LHTPTN+L+
Sbjct: 16 FCYQV-NGSCPRTVHTLGIQLVIYLACAAGMLIIVLGNVFVAFAVSYFKALHTPTNFLLL 74
Query: 64 SMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYY 123
S+A D LG LV+P S +RS E CW+FG+ C++HT D + SIFHL FISIDR+
Sbjct: 75 SLALADMFLGLLVLPLSTIRSVESCWFFGDFLCRLHTYLDTLFCLTSIFHLCFISIDRHC 134
Query: 124 AVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRGGCS 183
A+CDPL Y +K + V I W VPA + ++ ++ + + + + C G C
Sbjct: 135 AICDPLLYPSKFTVRVALRYILAGWGVPAAYTSLFLYTDVVETRLSQ-WLEEMPCVGSCQ 193
Query: 184 VFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDANQKLQIGLEMKNGISQ 243
+ +K G L F F++P IM+ +Y +I+++A QA+ I+ ++ L +
Sbjct: 194 LLLNKFWGWLNF-PLFFVPCLIMISLYVKIFVVATRQAQQITTLSKSL--------AGAA 244
Query: 244 SKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLIWFGYLNSTFNPMV 303
ERKA KTLGI +G++L+CW PF I T++D LH+I PP + D+ IWF Y NS NP++
Sbjct: 245 KHERKAAKTLGIAVGIYLLCWLPFTIDTMVDSLLHFITPPLVFDIFIWFAYFNSACNPII 304
Query: 304 YAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLE 336
Y F Y WFRKALK+ L K+F + L+ E
Sbjct: 305 YVFSYQWFRKALKLTLSQKVFSPQTRTVDLYQE 337
>gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens]
Length = 359
Score = 204 bits (519), Expect = 9e-53
Identities = 111/306 (36%), Positives = 169/306 (55%), Gaps = 12/306 (3%)
Query: 26 LYSLMVLIILTTLVGNLIVIVSISHFKQLHT-PTNWLIHSMATVDFLLGCLVMPYSMVRS 84
L + + +IL ++GNL+V+V++ +QL TN+ I S+A D L+ LVMP+ +
Sbjct: 22 LLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIEL 81
Query: 85 AEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVC-DPLRYKAKMNILVICVM 143
+ W +GEVFC + TS D++L++ASIFHL IS+DRYYA+C PL Y+ KM L I +M
Sbjct: 82 VQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALM 141
Query: 144 IFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRGG----CSVFFSKISGVLTFMTSF 199
+ W +P +F I N G ++ K + C +K + + +F
Sbjct: 142 LGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAF 201
Query: 200 YIPGSIMLCVYYRIYLIAKEQARLIS------DANQKLQIGLEMKNGISQSKERKAVKTL 253
YIP +M+ YYRIY+ AKE A I +++ + + E KA KTL
Sbjct: 202 YIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTL 261
Query: 254 GIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLIWFGYLNSTFNPMVYAFFYPWFRK 313
I+MG F +CW PFF+ ++DPF+ Y +P + +W GY+NS NP +YAF FR+
Sbjct: 262 CIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRR 321
Query: 314 ALKMML 319
A ++L
Sbjct: 322 AFLIIL 327
>gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens]
Length = 428
Score = 204 bits (519), Expect = 9e-53
Identities = 111/306 (36%), Positives = 169/306 (55%), Gaps = 12/306 (3%)
Query: 26 LYSLMVLIILTTLVGNLIVIVSISHFKQLHT-PTNWLIHSMATVDFLLGCLVMPYSMVRS 84
L + + +IL ++GNL+V+V++ +QL TN+ I S+A D L+ LVMP+ +
Sbjct: 22 LLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIEL 81
Query: 85 AEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVC-DPLRYKAKMNILVICVM 143
+ W +GEVFC + TS D++L++ASIFHL IS+DRYYA+C PL Y+ KM L I +M
Sbjct: 82 VQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALM 141
Query: 144 IFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRGG----CSVFFSKISGVLTFMTSF 199
+ W +P +F I N G ++ K + C +K + + +F
Sbjct: 142 LGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAF 201
Query: 200 YIPGSIMLCVYYRIYLIAKEQARLIS------DANQKLQIGLEMKNGISQSKERKAVKTL 253
YIP +M+ YYRIY+ AKE A I +++ + + E KA KTL
Sbjct: 202 YIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTL 261
Query: 254 GIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLIWFGYLNSTFNPMVYAFFYPWFRK 313
I+MG F +CW PFF+ ++DPF+ Y +P + +W GY+NS NP +YAF FR+
Sbjct: 262 CIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRR 321
Query: 314 ALKMML 319
A ++L
Sbjct: 322 AFLIIL 327
>gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens]
Length = 360
Score = 204 bits (519), Expect = 9e-53
Identities = 111/306 (36%), Positives = 169/306 (55%), Gaps = 12/306 (3%)
Query: 26 LYSLMVLIILTTLVGNLIVIVSISHFKQLHT-PTNWLIHSMATVDFLLGCLVMPYSMVRS 84
L + + +IL ++GNL+V+V++ +QL TN+ I S+A D L+ LVMP+ +
Sbjct: 22 LLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIEL 81
Query: 85 AEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVC-DPLRYKAKMNILVICVM 143
+ W +GEVFC + TS D++L++ASIFHL IS+DRYYA+C PL Y+ KM L I +M
Sbjct: 82 VQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALM 141
Query: 144 IFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRGG----CSVFFSKISGVLTFMTSF 199
+ W +P +F I N G ++ K + C +K + + +F
Sbjct: 142 LGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAF 201
Query: 200 YIPGSIMLCVYYRIYLIAKEQARLIS------DANQKLQIGLEMKNGISQSKERKAVKTL 253
YIP +M+ YYRIY+ AKE A I +++ + + E KA KTL
Sbjct: 202 YIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTL 261
Query: 254 GIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLIWFGYLNSTFNPMVYAFFYPWFRK 313
I+MG F +CW PFF+ ++DPF+ Y +P + +W GY+NS NP +YAF FR+
Sbjct: 262 CIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRR 321
Query: 314 ALKMML 319
A ++L
Sbjct: 322 AFLIIL 327
>gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens]
Length = 387
Score = 204 bits (519), Expect = 9e-53
Identities = 111/306 (36%), Positives = 169/306 (55%), Gaps = 12/306 (3%)
Query: 26 LYSLMVLIILTTLVGNLIVIVSISHFKQLHT-PTNWLIHSMATVDFLLGCLVMPYSMVRS 84
L + + +IL ++GNL+V+V++ +QL TN+ I S+A D L+ LVMP+ +
Sbjct: 22 LLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIEL 81
Query: 85 AEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVC-DPLRYKAKMNILVICVM 143
+ W +GEVFC + TS D++L++ASIFHL IS+DRYYA+C PL Y+ KM L I +M
Sbjct: 82 VQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALM 141
Query: 144 IFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRGG----CSVFFSKISGVLTFMTSF 199
+ W +P +F I N G ++ K + C +K + + +F
Sbjct: 142 LGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAF 201
Query: 200 YIPGSIMLCVYYRIYLIAKEQARLIS------DANQKLQIGLEMKNGISQSKERKAVKTL 253
YIP +M+ YYRIY+ AKE A I +++ + + E KA KTL
Sbjct: 202 YIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTL 261
Query: 254 GIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLIWFGYLNSTFNPMVYAFFYPWFRK 313
I+MG F +CW PFF+ ++DPF+ Y +P + +W GY+NS NP +YAF FR+
Sbjct: 262 CIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRR 321
Query: 314 ALKMML 319
A ++L
Sbjct: 322 AFLIIL 327
>gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens]
Length = 378
Score = 204 bits (519), Expect = 9e-53
Identities = 111/306 (36%), Positives = 169/306 (55%), Gaps = 12/306 (3%)
Query: 26 LYSLMVLIILTTLVGNLIVIVSISHFKQLHT-PTNWLIHSMATVDFLLGCLVMPYSMVRS 84
L + + +IL ++GNL+V+V++ +QL TN+ I S+A D L+ LVMP+ +
Sbjct: 22 LLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIEL 81
Query: 85 AEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVC-DPLRYKAKMNILVICVM 143
+ W +GEVFC + TS D++L++ASIFHL IS+DRYYA+C PL Y+ KM L I +M
Sbjct: 82 VQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALM 141
Query: 144 IFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRGG----CSVFFSKISGVLTFMTSF 199
+ W +P +F I N G ++ K + C +K + + +F
Sbjct: 142 LGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAF 201
Query: 200 YIPGSIMLCVYYRIYLIAKEQARLIS------DANQKLQIGLEMKNGISQSKERKAVKTL 253
YIP +M+ YYRIY+ AKE A I +++ + + E KA KTL
Sbjct: 202 YIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTL 261
Query: 254 GIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLIWFGYLNSTFNPMVYAFFYPWFRK 313
I+MG F +CW PFF+ ++DPF+ Y +P + +W GY+NS NP +YAF FR+
Sbjct: 262 CIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRR 321
Query: 314 ALKMML 319
A ++L
Sbjct: 322 AFLIIL 327
>gi|11321563 serotonin 5-HT4 receptor isoform b [Homo sapiens]
Length = 388
Score = 204 bits (519), Expect = 9e-53
Identities = 111/306 (36%), Positives = 169/306 (55%), Gaps = 12/306 (3%)
Query: 26 LYSLMVLIILTTLVGNLIVIVSISHFKQLHT-PTNWLIHSMATVDFLLGCLVMPYSMVRS 84
L + + +IL ++GNL+V+V++ +QL TN+ I S+A D L+ LVMP+ +
Sbjct: 22 LLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIEL 81
Query: 85 AEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVC-DPLRYKAKMNILVICVM 143
+ W +GEVFC + TS D++L++ASIFHL IS+DRYYA+C PL Y+ KM L I +M
Sbjct: 82 VQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALM 141
Query: 144 IFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRGG----CSVFFSKISGVLTFMTSF 199
+ W +P +F I N G ++ K + C +K + + +F
Sbjct: 142 LGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAF 201
Query: 200 YIPGSIMLCVYYRIYLIAKEQARLIS------DANQKLQIGLEMKNGISQSKERKAVKTL 253
YIP +M+ YYRIY+ AKE A I +++ + + E KA KTL
Sbjct: 202 YIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTL 261
Query: 254 GIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLIWFGYLNSTFNPMVYAFFYPWFRK 313
I+MG F +CW PFF+ ++DPF+ Y +P + +W GY+NS NP +YAF FR+
Sbjct: 262 CIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRR 321
Query: 314 ALKMML 319
A ++L
Sbjct: 322 AFLIIL 327
>gi|94421458 serotonin 5-HT4 receptor isoform hb [Homo sapiens]
Length = 402
Score = 201 bits (510), Expect = 1e-51
Identities = 113/320 (35%), Positives = 172/320 (53%), Gaps = 26/320 (8%)
Query: 26 LYSLMVLIILTTLVGNLIVIVSISHFKQLHT-PTNWLIHSMATVDFLLGCLVMPYSMVRS 84
L + + +IL ++GNL+V+V++ +QL TN+ I S+A D L+ LVMP+ +
Sbjct: 22 LLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIEL 81
Query: 85 AEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVC-DPLRYKAKMNILVICVM 143
+ W +GEVFC + TS D++L++ASIFHL IS+DRYYA+C PL Y+ KM L I +M
Sbjct: 82 VQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALM 141
Query: 144 IFISWSVPAVFAF----------GMIFLELN--------FKGAEEIYYKHVHCRGGCSVF 185
+ W +P +F G+I LE + F E+ + C
Sbjct: 142 LGGCWVIPTFISFLPIMQGWNNIGIIDLERSLNQGLGQDFHAIEKRKFNQNSNSTYCVFM 201
Query: 186 FSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLIS------DANQKLQIGLEMKN 239
+K + + +FYIP +M+ YYRIY+ AKE A I +++ + +
Sbjct: 202 VNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHS 261
Query: 240 GISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLIWFGYLNSTF 299
E KA KTL I+MG F +CW PFF+ ++DPF+ Y +P + +W GY+NS
Sbjct: 262 THRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGL 321
Query: 300 NPMVYAFFYPWFRKALKMML 319
NP +YAF FR+A ++L
Sbjct: 322 NPFLYAFLNKSFRRAFLIIL 341
>gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens]
Length = 397
Score = 180 bits (456), Expect = 2e-45
Identities = 102/316 (32%), Positives = 167/316 (52%), Gaps = 13/316 (4%)
Query: 19 SNDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNWLIHSMATVDFLLGCLVMP 78
S + ++ ++ ++IL T+ GN++V +++ ++L TN I S+A D LLG LV+P
Sbjct: 14 STACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLP 73
Query: 79 YSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVCDPLRYKAKMNIL 138
+S + W FG+VFC I+TS D+ML +ASI +L IS+DRY AV DPLRY + +
Sbjct: 74 FSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPV 133
Query: 139 VICVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRGGCSVFFSKISGVLTFMTS 198
+ + + + W + +F I L N + K H C V +++ G++ + +
Sbjct: 134 RVAISLVLIWVISITLSFLSIHLGWNSRNETS---KGNHTTSKCKVQVNEVYGLVDGLVT 190
Query: 199 FYIPGSIMLCVYYRIYLIAKEQARLISDANQKLQIGLEMKNGISQSKERKAVKTLGIVMG 258
FY+P IM YYRI+ +A++QA+ I+ + + +E KA TL VMG
Sbjct: 191 FYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATI---------REHKATVTLAAVMG 241
Query: 259 VFLICWCPFFICTVMDPFL-HYIIPPTLNDVLIWFGYLNSTFNPMVYAFFYPWFRKALKM 317
F+ICW P+F V I L +++W GY NS NP++YA FR +
Sbjct: 242 AFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQ 301
Query: 318 MLFGKIFQKDSSRCKL 333
+ ++ ++S + L
Sbjct: 302 LFCCRLANRNSHKTSL 317
>gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens]
Length = 359
Score = 180 bits (456), Expect = 2e-45
Identities = 102/316 (32%), Positives = 167/316 (52%), Gaps = 13/316 (4%)
Query: 19 SNDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNWLIHSMATVDFLLGCLVMP 78
S + ++ ++ ++IL T+ GN++V +++ ++L TN I S+A D LLG LV+P
Sbjct: 14 STACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLP 73
Query: 79 YSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVCDPLRYKAKMNIL 138
+S + W FG+VFC I+TS D+ML +ASI +L IS+DRY AV DPLRY + +
Sbjct: 74 FSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPV 133
Query: 139 VICVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRGGCSVFFSKISGVLTFMTS 198
+ + + + W + +F I L N + K H C V +++ G++ + +
Sbjct: 134 RVAISLVLIWVISITLSFLSIHLGWNSRNETS---KGNHTTSKCKVQVNEVYGLVDGLVT 190
Query: 199 FYIPGSIMLCVYYRIYLIAKEQARLISDANQKLQIGLEMKNGISQSKERKAVKTLGIVMG 258
FY+P IM YYRI+ +A++QA+ I+ + + +E KA TL VMG
Sbjct: 191 FYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATI---------REHKATVTLAAVMG 241
Query: 259 VFLICWCPFFICTVMDPFL-HYIIPPTLNDVLIWFGYLNSTFNPMVYAFFYPWFRKALKM 317
F+ICW P+F V I L +++W GY NS NP++YA FR +
Sbjct: 242 AFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQ 301
Query: 318 MLFGKIFQKDSSRCKL 333
+ ++ ++S + L
Sbjct: 302 LFCCRLANRNSHKTSL 317
>gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo
sapiens]
Length = 377
Score = 172 bits (435), Expect = 5e-43
Identities = 114/345 (33%), Positives = 171/345 (49%), Gaps = 57/345 (16%)
Query: 22 VRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNWLIHSMATVDFLLGCLVMPYSM 81
++ SL ++ +I L T++ N V+ +I ++LHTP N+LI S+AT D L+ LVMP S+
Sbjct: 37 LKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISI 96
Query: 82 VRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVCDPLRYKAKMNILVIC 141
+ H W FG++ C I S+DI +ASI HL I++DRY+A+ D L Y +
Sbjct: 97 AYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAA 156
Query: 142 VMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRGGCSVFFSKIS-GVLTFMTSFY 200
MI I W++ + +F K EE+ C V S+IS + + +FY
Sbjct: 157 TMIAIVWAISICISIPPLFWR-QAKAQEEM--------SDCLVNTSQISYTIYSTCGAFY 207
Query: 201 IPGSIMLCVYYRIYLIAKEQ--------------ARLISDA--------NQKLQIG---- 234
IP +++ +Y RIY A+ + A LI+ + N L G
Sbjct: 208 IPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHS 267
Query: 235 ------------------LEMKNGISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPF 276
LE K IS ++ERKA K LGI++G F+ICW PFF+ +++ P
Sbjct: 268 AGSPLFFNHVKIKLADSALERKR-ISAARERKATKILGIILGAFIICWLPFFVVSLVLPI 326
Query: 277 LH--YIIPPTLNDVLIWFGYLNSTFNPMVYAFFYPWFRKALKMML 319
I P L D W GYLNS NP++Y F FR+A + ++
Sbjct: 327 CRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIV 371
>gi|4503383 dopamine receptor D1 [Homo sapiens]
Length = 446
Score = 170 bits (431), Expect = 1e-42
Identities = 110/328 (33%), Positives = 170/328 (51%), Gaps = 34/328 (10%)
Query: 22 VRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTP-TNWLIHSMATVDFLLGCLVMPYS 80
VR + L+IL+TL+GN +V ++ F+ L + TN+ + S+A D L+ LVMP+
Sbjct: 22 VRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWK 81
Query: 81 MVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVCDPLRYKAKMNILVI 140
V W FG FC I + DIM S+ASI +L IS+DRY+A+ P RY+ KM
Sbjct: 82 AVAEIAGFWPFGS-FCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAA 140
Query: 141 CVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRG------GCSVFFSKISGVLT 194
++I ++W++ + +F I ++L++ A+ + C S+ + +
Sbjct: 141 FILISVAWTLSVLISF--IPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISS 198
Query: 195 FMTSFYIPGSIMLCVYYRIYLIAKEQARLISDANQKLQIGLEMK----NG---------- 240
+ SFYIP +IM+ Y RIY IA++Q R I+ + + NG
Sbjct: 199 SVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPES 258
Query: 241 ---ISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFL------HYIIPPTLNDVLIW 291
+S +E K +KTL ++MGVF+ CW PFFI + PF + I DV +W
Sbjct: 259 SFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVW 318
Query: 292 FGYLNSTFNPMVYAFFYPWFRKALKMML 319
FG+ NS+ NP++YAF FRKA +L
Sbjct: 319 FGWANSSLNPIIYAFNAD-FRKAFSTLL 345
>gi|4503391 dopamine receptor D5 [Homo sapiens]
Length = 477
Score = 169 bits (428), Expect = 3e-42
Identities = 108/317 (34%), Positives = 160/317 (50%), Gaps = 40/317 (12%)
Query: 29 LMVLIILTTLVGNLIVIVSISHFKQLHTP-TNWLIHSMATVDFLLGCLVMPYSMVRSAEH 87
L+ L+I+ TL+GN++V +I + L TN I S+A D + LVMP+ V
Sbjct: 46 LLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAG 105
Query: 88 CWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVCDPLRYKAKMNILVICVMIFIS 147
W FG FC + + DIM S+ASI +L IS+DRY+A+ P RYK KM + VM+ ++
Sbjct: 106 YWPFG-AFCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLA 164
Query: 148 WSVPAVFAFGMIFLE------------------LNFKGAEEIYYKHVHCRGGCSVFFSKI 189
W++ + +F + L N+ EE +++ C ++
Sbjct: 165 WTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRT 224
Query: 190 SGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDANQKLQIGLEMKNG--------- 240
+ + + SFYIP +IM+ Y RIY IA+ Q R IS + + ++
Sbjct: 225 YAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAACAPDTSL 284
Query: 241 -ISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFL--HYIIPP--------TLNDVL 289
S KE K +KTL ++MGVF+ CW PFFI M PF H PP T DV
Sbjct: 285 RASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVF 344
Query: 290 IWFGYLNSTFNPMVYAF 306
+WFG+ NS+ NP++YAF
Sbjct: 345 VWFGWANSSLNPVIYAF 361
>gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens]
Length = 413
Score = 167 bits (422), Expect = 2e-41
Identities = 97/307 (31%), Positives = 163/307 (53%), Gaps = 21/307 (6%)
Query: 29 LMVLIILTTLVGNLIVIVSISHFKQLHTPTNWLIHSMATVDFLLGCLVMPYSMVRSAEHC 88
+M LI+L + GN++VI +I+ F++L T TN+ I S+A D ++G V+P+
Sbjct: 39 VMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKM 98
Query: 89 WYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVCDPLRYKAKMNILVICVMIFISW 148
W FG +C+ TS D++ +ASI L I++DRY+A+ P +Y++ + V+I + W
Sbjct: 99 WTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVW 158
Query: 149 SVPAVFAFGMIFLELNFKGAEEIYYKHVHCRGG---CSVFFSKISGVLTFMTSFYIPGSI 205
V + + FL + + + ++C C F ++ + + + SFY+P I
Sbjct: 159 IVSGLTS----FLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVI 214
Query: 206 MLCVYYRIYLIAKEQARLISDANQKLQI--------GLEMKNGISQS-----KERKAVKT 252
M+ VY R++ AK Q + I + + + +G+ +S KE KA+KT
Sbjct: 215 MVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKT 274
Query: 253 LGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLIWFGYLNSTFNPMVYAFFYPWFR 312
LGI+MG F +CW PFFI ++ +I + +L W GY+NS FNP++Y P FR
Sbjct: 275 LGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYC-RSPDFR 333
Query: 313 KALKMML 319
A + +L
Sbjct: 334 IAFQELL 340
>gi|4557265 beta-1-adrenergic receptor [Homo sapiens]
Length = 477
Score = 160 bits (406), Expect = 1e-39
Identities = 100/337 (29%), Positives = 164/337 (48%), Gaps = 45/337 (13%)
Query: 24 ASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNWLIHSMATVDFLLGCLVMPYSMVR 83
A + LM LI+L + GN++VIV+I+ +L T TN I S+A+ D ++G LV+P+
Sbjct: 59 AGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATI 118
Query: 84 SAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVCDPLRYKAKMNILVICVM 143
W +G FC++ TS D++ +ASI L I++DRY A+ P RY++ + +
Sbjct: 119 VVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGL 178
Query: 144 IFISWSVPAVFAFGMIFLELNFKGAEEI--YYKHVHCRGGCSVFFSKISGVLTFMTSFYI 201
+ W++ A+ +F I + ++E Y C C ++ + + + SFY+
Sbjct: 179 VCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKC---CDFVTNRAYAIASSVVSFYV 235
Query: 202 PGSIMLCVYYRIYLIAKEQARLISDANQKL------------------------------ 231
P IM VY R++ A++Q + I ++
Sbjct: 236 PLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAA 295
Query: 232 ---------QIGLEMKNGISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIP 282
+ G + + +E+KA+KTLGI+MGVF +CW PFF+ V+ F ++P
Sbjct: 296 AATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVP 355
Query: 283 PTLNDVLIWFGYLNSTFNPMVYAFFYPWFRKALKMML 319
L W GY NS FNP++Y P FRKA + +L
Sbjct: 356 DRLFVFFNWLGYANSAFNPIIYC-RSPDFRKAFQGLL 391
>gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]
Length = 455
Score = 154 bits (388), Expect = 1e-37
Identities = 98/315 (31%), Positives = 160/315 (50%), Gaps = 37/315 (11%)
Query: 33 IILTTLVGNLIVIVSISHFKQLHTPTNWLIHSMATVDFLLGCLVMPYSMVRSAEHCWYFG 92
+IL ++GN++VI+S++ + LH+ T++ I ++A D LL V+P+S + W FG
Sbjct: 36 LILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFG 95
Query: 93 EVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVCDPLRYKAKMNILVICVMIFISWSVPA 152
VFC I + D++ +ASI L ISIDRY V PLRY + + + W++
Sbjct: 96 RVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSL 155
Query: 153 VFAFGMIFLELNFKGAEEIYYKHVHCRGGCSVFFSKISGVLTFMTSFYIPGSIMLCVYYR 212
V + G +F +E C + + + + SFY+P +I+L +Y R
Sbjct: 156 VISIGPLFGWRQPAPEDETI---------CQINEEPGYVLFSALGSFYLPLAIILVMYCR 206
Query: 213 IYLIAKEQAR-----LISDANQKLQIGLEM--KNG--------------------ISQSK 245
+Y++AK ++R L +D + Q+ L + KN + S+
Sbjct: 207 VYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSR 266
Query: 246 ERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIP-PTLNDVLIWFGYLNSTFNPMVY 304
E+KA KTLGIV+G F++CW PFF+ + F P T+ ++ W GYLNS NP++Y
Sbjct: 267 EKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIY 326
Query: 305 AFFYPWFRKALKMML 319
F+KA + +L
Sbjct: 327 PCSSQEFKKAFQNVL 341
>gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]
Length = 466
Score = 154 bits (388), Expect = 1e-37
Identities = 98/315 (31%), Positives = 160/315 (50%), Gaps = 37/315 (11%)
Query: 33 IILTTLVGNLIVIVSISHFKQLHTPTNWLIHSMATVDFLLGCLVMPYSMVRSAEHCWYFG 92
+IL ++GN++VI+S++ + LH+ T++ I ++A D LL V+P+S + W FG
Sbjct: 36 LILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFG 95
Query: 93 EVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVCDPLRYKAKMNILVICVMIFISWSVPA 152
VFC I + D++ +ASI L ISIDRY V PLRY + + + W++
Sbjct: 96 RVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSL 155
Query: 153 VFAFGMIFLELNFKGAEEIYYKHVHCRGGCSVFFSKISGVLTFMTSFYIPGSIMLCVYYR 212
V + G +F +E C + + + + SFY+P +I+L +Y R
Sbjct: 156 VISIGPLFGWRQPAPEDETI---------CQINEEPGYVLFSALGSFYLPLAIILVMYCR 206
Query: 213 IYLIAKEQAR-----LISDANQKLQIGLEM--KNG--------------------ISQSK 245
+Y++AK ++R L +D + Q+ L + KN + S+
Sbjct: 207 VYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSR 266
Query: 246 ERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIP-PTLNDVLIWFGYLNSTFNPMVY 304
E+KA KTLGIV+G F++CW PFF+ + F P T+ ++ W GYLNS NP++Y
Sbjct: 267 EKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIY 326
Query: 305 AFFYPWFRKALKMML 319
F+KA + +L
Sbjct: 327 PCSSQEFKKAFQNVL 341
>gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]
Length = 475
Score = 154 bits (388), Expect = 1e-37
Identities = 98/315 (31%), Positives = 160/315 (50%), Gaps = 37/315 (11%)
Query: 33 IILTTLVGNLIVIVSISHFKQLHTPTNWLIHSMATVDFLLGCLVMPYSMVRSAEHCWYFG 92
+IL ++GN++VI+S++ + LH+ T++ I ++A D LL V+P+S + W FG
Sbjct: 36 LILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFG 95
Query: 93 EVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVCDPLRYKAKMNILVICVMIFISWSVPA 152
VFC I + D++ +ASI L ISIDRY V PLRY + + + W++
Sbjct: 96 RVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSL 155
Query: 153 VFAFGMIFLELNFKGAEEIYYKHVHCRGGCSVFFSKISGVLTFMTSFYIPGSIMLCVYYR 212
V + G +F +E C + + + + SFY+P +I+L +Y R
Sbjct: 156 VISIGPLFGWRQPAPEDETI---------CQINEEPGYVLFSALGSFYLPLAIILVMYCR 206
Query: 213 IYLIAKEQAR-----LISDANQKLQIGLEM--KNG--------------------ISQSK 245
+Y++AK ++R L +D + Q+ L + KN + S+
Sbjct: 207 VYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSR 266
Query: 246 ERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIP-PTLNDVLIWFGYLNSTFNPMVY 304
E+KA KTLGIV+G F++CW PFF+ + F P T+ ++ W GYLNS NP++Y
Sbjct: 267 EKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIY 326
Query: 305 AFFYPWFRKALKMML 319
F+KA + +L
Sbjct: 327 PCSSQEFKKAFQNVL 341
>gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]
Length = 429
Score = 154 bits (388), Expect = 1e-37
Identities = 98/315 (31%), Positives = 160/315 (50%), Gaps = 37/315 (11%)
Query: 33 IILTTLVGNLIVIVSISHFKQLHTPTNWLIHSMATVDFLLGCLVMPYSMVRSAEHCWYFG 92
+IL ++GN++VI+S++ + LH+ T++ I ++A D LL V+P+S + W FG
Sbjct: 36 LILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFG 95
Query: 93 EVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVCDPLRYKAKMNILVICVMIFISWSVPA 152
VFC I + D++ +ASI L ISIDRY V PLRY + + + W++
Sbjct: 96 RVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSL 155
Query: 153 VFAFGMIFLELNFKGAEEIYYKHVHCRGGCSVFFSKISGVLTFMTSFYIPGSIMLCVYYR 212
V + G +F +E C + + + + SFY+P +I+L +Y R
Sbjct: 156 VISIGPLFGWRQPAPEDETI---------CQINEEPGYVLFSALGSFYLPLAIILVMYCR 206
Query: 213 IYLIAKEQAR-----LISDANQKLQIGLEM--KNG--------------------ISQSK 245
+Y++AK ++R L +D + Q+ L + KN + S+
Sbjct: 207 VYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSR 266
Query: 246 ERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIP-PTLNDVLIWFGYLNSTFNPMVY 304
E+KA KTLGIV+G F++CW PFF+ + F P T+ ++ W GYLNS NP++Y
Sbjct: 267 EKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIY 326
Query: 305 AFFYPWFRKALKMML 319
F+KA + +L
Sbjct: 327 PCSSQEFKKAFQNVL 341
>gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens]
Length = 432
Score = 154 bits (388), Expect = 1e-37
Identities = 102/335 (30%), Positives = 156/335 (46%), Gaps = 42/335 (12%)
Query: 17 NWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNWLIHSMATVDFLLGCLV 76
N+ + + S++ LI L T+ GN +V++S+ K+L P+N+LI S+A D + V
Sbjct: 75 NYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAV 134
Query: 77 MPY-SMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVCDPLRYKAKM 135
MP+ S+ W FG FC + + D+M +ASI L ISIDRY + PL Y +
Sbjct: 135 MPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQ 194
Query: 136 NILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRGGCSVFFSKISGVLTF 195
N + MI W + A +F + ++V+ C + + +
Sbjct: 195 NGKCMAKMILSVWLLSASITLPPLF----------GWAQNVNDDKVCLISQDFGYTIYST 244
Query: 196 MTSFYIPGSIMLCVYYRIYLIAKEQA---------RLISD------------------AN 228
+FYIP S+ML +YY+IY A++ A R+ D AN
Sbjct: 245 AVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECAN 304
Query: 229 QKLQIGLEMKNGISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFL----HYIIPPT 284
+ E KN +E+KA TLGI++G F +CW PFF+ + PF+ IP
Sbjct: 305 LSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLW 364
Query: 285 LNDVLIWFGYLNSTFNPMVYAFFYPWFRKALKMML 319
+ +W GY NS NP +YAFF R + +L
Sbjct: 365 VERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLL 399
>gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens]
Length = 479
Score = 154 bits (388), Expect = 1e-37
Identities = 102/335 (30%), Positives = 156/335 (46%), Gaps = 42/335 (12%)
Query: 17 NWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNWLIHSMATVDFLLGCLV 76
N+ + + S++ LI L T+ GN +V++S+ K+L P+N+LI S+A D + V
Sbjct: 75 NYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAV 134
Query: 77 MPY-SMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVCDPLRYKAKM 135
MP+ S+ W FG FC + + D+M +ASI L ISIDRY + PL Y +
Sbjct: 135 MPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQ 194
Query: 136 NILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRGGCSVFFSKISGVLTF 195
N + MI W + A +F + ++V+ C + + +
Sbjct: 195 NGKCMAKMILSVWLLSASITLPPLF----------GWAQNVNDDKVCLISQDFGYTIYST 244
Query: 196 MTSFYIPGSIMLCVYYRIYLIAKEQA---------RLISD------------------AN 228
+FYIP S+ML +YY+IY A++ A R+ D AN
Sbjct: 245 AVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECAN 304
Query: 229 QKLQIGLEMKNGISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFL----HYIIPPT 284
+ E KN +E+KA TLGI++G F +CW PFF+ + PF+ IP
Sbjct: 305 LSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLW 364
Query: 285 LNDVLIWFGYLNSTFNPMVYAFFYPWFRKALKMML 319
+ +W GY NS NP +YAFF R + +L
Sbjct: 365 VERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLL 399
>gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens]
Length = 445
Score = 154 bits (388), Expect = 1e-37
Identities = 102/335 (30%), Positives = 156/335 (46%), Gaps = 42/335 (12%)
Query: 17 NWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNWLIHSMATVDFLLGCLV 76
N+ + + S++ LI L T+ GN +V++S+ K+L P+N+LI S+A D + V
Sbjct: 75 NYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAV 134
Query: 77 MPY-SMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVCDPLRYKAKM 135
MP+ S+ W FG FC + + D+M +ASI L ISIDRY + PL Y +
Sbjct: 135 MPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQ 194
Query: 136 NILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRGGCSVFFSKISGVLTF 195
N + MI W + A +F + ++V+ C + + +
Sbjct: 195 NGKCMAKMILSVWLLSASITLPPLF----------GWAQNVNDDKVCLISQDFGYTIYST 244
Query: 196 MTSFYIPGSIMLCVYYRIYLIAKEQA---------RLISD------------------AN 228
+FYIP S+ML +YY+IY A++ A R+ D AN
Sbjct: 245 AVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECAN 304
Query: 229 QKLQIGLEMKNGISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFL----HYIIPPT 284
+ E KN +E+KA TLGI++G F +CW PFF+ + PF+ IP
Sbjct: 305 LSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLW 364
Query: 285 LNDVLIWFGYLNSTFNPMVYAFFYPWFRKALKMML 319
+ +W GY NS NP +YAFF R + +L
Sbjct: 365 VERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLL 399
>gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo
sapiens]
Length = 366
Score = 153 bits (387), Expect = 2e-37
Identities = 109/357 (30%), Positives = 165/357 (46%), Gaps = 65/357 (18%)
Query: 16 NNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNWLIHSMATVDFLLGCL 75
N + + SL +L L ++TT + N +VI +I ++LH P N+LI S+A DFL+ L
Sbjct: 18 NRMPSKILVSL-TLSGLALMTTTI-NSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVL 75
Query: 76 VMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVCDPLRYKAKM 135
VMP+S+V W G+V C I S DI + SI HLS I++DRY A+ D + Y K
Sbjct: 76 VMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKR 135
Query: 136 NILVICVMIFISWSVPAVFAFGMIF-LELNFKGAEEIYYKHVHCRGGCSVFFSKISGVLT 194
+MI I W + + +F +E KH H +S + +
Sbjct: 136 TPKHAGIMITIVWIISVFISMPPLFWRHQGTSRDDECIIKHDHI----------VSTIYS 185
Query: 195 FMTSFYIPGSIMLCVYYRIY-----LIAKEQARLISDANQKLQIGLE------------- 236
+FYIP +++L +YY+IY L K QA I+ Q+ LE
Sbjct: 186 TFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVSTSY 245
Query: 237 ---------------------------------MKNGISQSKERKAVKTLGIVMGVFLIC 263
+ IS ++ERKA TLG+++G F+IC
Sbjct: 246 VLEKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILGAFVIC 305
Query: 264 WCPFFIC-TVMDPFLHYIIPPTLNDVLIWFGYLNSTFNPMVYAFFYPWFRKALKMML 319
W PFF+ V++ I +++ L W GYLNS NP++Y F F+KA + ++
Sbjct: 306 WLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLV 362
>gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo
sapiens]
Length = 440
Score = 150 bits (379), Expect = 2e-36
Identities = 94/309 (30%), Positives = 152/309 (49%), Gaps = 25/309 (8%)
Query: 30 MVLIILTTLVGNLIVIVSISHFKQLHTPTNWLIHSMATVDFLLGCLVMPYSMVRSAEHCW 89
+ ++I T N ++I I L +N+ + S+ T D ++G +VMP +M+ + W
Sbjct: 33 LCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRW 92
Query: 90 YFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVCDPLRYKAKMNILVICVMIFISWS 149
C + T+ D+M SASI +L IS+DRY + PLRYK +M L ++ +WS
Sbjct: 93 VLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWS 152
Query: 150 VPAVFAFGMIFLELNFKGAEEIYYKHVHCRGGCSVFFSKISGVLTFMTSFYIPGSIMLCV 209
+ A+ +F + L G E+ + G C + S ++ +F++P +
Sbjct: 153 LAALASFLPLLL-----GWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFT 207
Query: 210 YYRIYLIAKEQA--------RLISDANQKLQIGLEMKNGISQSKER-----------KAV 250
Y RI L A++QA + S A++ LQ+ + G+ + R KA
Sbjct: 208 YCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKAS 267
Query: 251 KTLGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLIWFGYLNSTFNPMVYAFFYPW 310
TLGI++G+F + W PFF+ ++ I P L DVL W GY NST NP++Y F
Sbjct: 268 LTLGILLGMFFVTWLPFFVANIVQAVCD-CISPGLFDVLTWLGYCNSTMNPIIYPLFMRD 326
Query: 311 FRKALKMML 319
F++AL L
Sbjct: 327 FKRALGRFL 335
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.332 0.143 0.465
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,675,954
Number of Sequences: 37866
Number of extensions: 451237
Number of successful extensions: 2897
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 598
Number of HSP's successfully gapped in prelim test: 137
Number of HSP's that attempted gapping in prelim test: 1237
Number of HSP's gapped (non-prelim): 946
length of query: 339
length of database: 18,247,518
effective HSP length: 103
effective length of query: 236
effective length of database: 14,347,320
effective search space: 3385967520
effective search space used: 3385967520
T: 11
A: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (22.0 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.