Guide to the Human Genome
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Search of human proteins with 212549782

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|212549782 caspase 8 associated protein 2 [Homo sapiens]
         (1982 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|212549782 caspase 8 associated protein 2 [Homo sapiens]           3954   0.0  
gi|6912288 caspase 8 associated protein 2 [Homo sapiens]             3954   0.0  
gi|212549532 caspase 8 associated protein 2 [Homo sapiens]           3954   0.0  
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]         76   4e-13
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]         76   4e-13
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ...    70   2e-11
gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [...    70   2e-11
gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]     62   4e-09
gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain ...    62   4e-09
gi|42560244 peptidylprolyl isomerase G [Homo sapiens]                  62   6e-09
gi|87299628 biorientation of chromosomes in cell division 1-like...    62   7e-09
gi|82830424 gon-4-like isoform a [Homo sapiens]                        62   7e-09
gi|109255228 centrosomal protein 170kDa isoform alpha [Homo sapi...    61   1e-08
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ...    60   2e-08
gi|109255230 centrosomal protein 170kDa isoform beta [Homo sapiens]    60   2e-08
gi|109255232 centrosomal protein 170kDa isoform gamma [Homo sapi...    60   2e-08
gi|148746195 trichohyalin [Homo sapiens]                               60   3e-08
gi|6631100 natural killer-tumor recognition sequence [Homo sapiens]    59   4e-08
gi|239747174 PREDICTED: hypothetical protein XP_002343931, parti...    59   5e-08
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]            58   1e-07
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]     57   1e-07
gi|50962882 G patch domain containing 8 [Homo sapiens]                 57   1e-07
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li...    57   2e-07
gi|71061468 centromere protein E [Homo sapiens]                        56   3e-07
gi|154146223 splicing factor, arginine/serine-rich 130 [Homo sap...    56   3e-07
gi|154146193 splicing factor, arginine/serine-rich 130 [Homo sap...    56   3e-07
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]        55   5e-07
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa...    55   7e-07
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik...    55   7e-07
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]    55   7e-07

>gi|212549782 caspase 8 associated protein 2 [Homo sapiens]
          Length = 1982

 Score = 3954 bits (10253), Expect = 0.0
 Identities = 1982/1982 (100%), Positives = 1982/1982 (100%)

Query: 1    MAADDDNGDGTSLFDVFSASPLKNNDEGSLDIYAGLDSAVSDSASKSCVPSRNCLDLYEE 60
            MAADDDNGDGTSLFDVFSASPLKNNDEGSLDIYAGLDSAVSDSASKSCVPSRNCLDLYEE
Sbjct: 1    MAADDDNGDGTSLFDVFSASPLKNNDEGSLDIYAGLDSAVSDSASKSCVPSRNCLDLYEE 60

Query: 61   ILTEEGTAKEATYNDLQVEYGKCQLQMKELMKKFKEIQTQNFSLINENQSLKKNISALIK 120
            ILTEEGTAKEATYNDLQVEYGKCQLQMKELMKKFKEIQTQNFSLINENQSLKKNISALIK
Sbjct: 61   ILTEEGTAKEATYNDLQVEYGKCQLQMKELMKKFKEIQTQNFSLINENQSLKKNISALIK 120

Query: 121  TARVEINRKDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHR 180
            TARVEINRKDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHR
Sbjct: 121  TARVEINRKDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHR 180

Query: 181  AKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSN 240
            AKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSN
Sbjct: 181  AKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSN 240

Query: 241  EDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTES 300
            EDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTES
Sbjct: 241  EDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTES 300

Query: 301  KSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKS 360
            KSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKS
Sbjct: 301  KSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKS 360

Query: 361  QDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRD 420
            QDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRD
Sbjct: 361  QDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRD 420

Query: 421  KSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESK 480
            KSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESK
Sbjct: 421  KSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESK 480

Query: 481  EENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAM 540
            EENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAM
Sbjct: 481  EENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAM 540

Query: 541  KAESGPNETKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITDIPKSSGVCDSESSMQV 600
            KAESGPNETKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITDIPKSSGVCDSESSMQV
Sbjct: 541  KAESGPNETKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITDIPKSSGVCDSESSMQV 600

Query: 601  KTVAYVPSISEHILGEAAVSEHTMGETKSTLLEPKVALLAVTEPRIGISETNKEDENSLL 660
            KTVAYVPSISEHILGEAAVSEHTMGETKSTLLEPKVALLAVTEPRIGISETNKEDENSLL
Sbjct: 601  KTVAYVPSISEHILGEAAVSEHTMGETKSTLLEPKVALLAVTEPRIGISETNKEDENSLL 660

Query: 661  VRSVDNTMHCEEPICGTETSFPSPMEIQQTESLFPSTGMKQTINNGRAAAPVVMDVLQTD 720
            VRSVDNTMHCEEPICGTETSFPSPMEIQQTESLFPSTGMKQTINNGRAAAPVVMDVLQTD
Sbjct: 661  VRSVDNTMHCEEPICGTETSFPSPMEIQQTESLFPSTGMKQTINNGRAAAPVVMDVLQTD 720

Query: 721  VSQNFGLELDTKRNDNSDYCGISEGMEMKVALSTTVSETTESILQPSIEEADILPIMLSE 780
            VSQNFGLELDTKRNDNSDYCGISEGMEMKVALSTTVSETTESILQPSIEEADILPIMLSE
Sbjct: 721  VSQNFGLELDTKRNDNSDYCGISEGMEMKVALSTTVSETTESILQPSIEEADILPIMLSE 780

Query: 781  DNNPKFEPSVIVTPLVESKSCHLEPCLPKETLDSSLQQTELMDHRMATGETNSVYHDDDN 840
            DNNPKFEPSVIVTPLVESKSCHLEPCLPKETLDSSLQQTELMDHRMATGETNSVYHDDDN
Sbjct: 781  DNNPKFEPSVIVTPLVESKSCHLEPCLPKETLDSSLQQTELMDHRMATGETNSVYHDDDN 840

Query: 841  SVLSIDLNHLRPIPEAISPLNSPVRPVAKVLRNESPPQVPVYNNSHKDVFLPNSAHSTSK 900
            SVLSIDLNHLRPIPEAISPLNSPVRPVAKVLRNESPPQVPVYNNSHKDVFLPNSAHSTSK
Sbjct: 841  SVLSIDLNHLRPIPEAISPLNSPVRPVAKVLRNESPPQVPVYNNSHKDVFLPNSAHSTSK 900

Query: 901  SQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKNSKRRVS 960
            SQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKNSKRRVS
Sbjct: 901  SQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKNSKRRVS 960

Query: 961  ADVRKSKTIPRRGKSTVCLDKDSRKTHVRIHQTNNKWNKRPDKSSRSSKTEKKDKVMSTS 1020
            ADVRKSKTIPRRGKSTVCLDKDSRKTHVRIHQTNNKWNKRPDKSSRSSKTEKKDKVMSTS
Sbjct: 961  ADVRKSKTIPRRGKSTVCLDKDSRKTHVRIHQTNNKWNKRPDKSSRSSKTEKKDKVMSTS 1020

Query: 1021 SLEKIVPIIAVPSSEQEIMHMLRMIRKHVRKNYMKFKAKFSLIQFHRIIESAILSFTSLI 1080
            SLEKIVPIIAVPSSEQEIMHMLRMIRKHVRKNYMKFKAKFSLIQFHRIIESAILSFTSLI
Sbjct: 1021 SLEKIVPIIAVPSSEQEIMHMLRMIRKHVRKNYMKFKAKFSLIQFHRIIESAILSFTSLI 1080

Query: 1081 KHLNLHKISKSVTTLQKNLCDIIESKLKQVKKNGIVDRLFEQQLPDMKKKLWKFVDDQLD 1140
            KHLNLHKISKSVTTLQKNLCDIIESKLKQVKKNGIVDRLFEQQLPDMKKKLWKFVDDQLD
Sbjct: 1081 KHLNLHKISKSVTTLQKNLCDIIESKLKQVKKNGIVDRLFEQQLPDMKKKLWKFVDDQLD 1140

Query: 1141 YLFAKLKKILVCDSKSFGRDSDEGKLEKTSKQNAQYSNSQKRSVDNSNRELLKEKLSKSE 1200
            YLFAKLKKILVCDSKSFGRDSDEGKLEKTSKQNAQYSNSQKRSVDNSNRELLKEKLSKSE
Sbjct: 1141 YLFAKLKKILVCDSKSFGRDSDEGKLEKTSKQNAQYSNSQKRSVDNSNRELLKEKLSKSE 1200

Query: 1201 DPVHYKSLVGCKKSEENYQDQNNSSINTVKHDIKKNFNICFDNIKNSQSEERSLEVHCPS 1260
            DPVHYKSLVGCKKSEENYQDQNNSSINTVKHDIKKNFNICFDNIKNSQSEERSLEVHCPS
Sbjct: 1201 DPVHYKSLVGCKKSEENYQDQNNSSINTVKHDIKKNFNICFDNIKNSQSEERSLEVHCPS 1260

Query: 1261 TPKSEKNEGSSIEDAQTSQHATLKPERSFEILTEQQASSLTFNLVSDAQMGEIFKSLLQG 1320
            TPKSEKNEGSSIEDAQTSQHATLKPERSFEILTEQQASSLTFNLVSDAQMGEIFKSLLQG
Sbjct: 1261 TPKSEKNEGSSIEDAQTSQHATLKPERSFEILTEQQASSLTFNLVSDAQMGEIFKSLLQG 1320

Query: 1321 SDLLDSSVNCTEKSEWELKTPEKQLLETLKCESIPACTTEELVSGVASPCPKMISDDNWS 1380
            SDLLDSSVNCTEKSEWELKTPEKQLLETLKCESIPACTTEELVSGVASPCPKMISDDNWS
Sbjct: 1321 SDLLDSSVNCTEKSEWELKTPEKQLLETLKCESIPACTTEELVSGVASPCPKMISDDNWS 1380

Query: 1381 LLSSEKGPSLSSGLSLPVHPDVLDESCMFEVSTNLPLSKDNVCSVEKSKPCVSSILLEDL 1440
            LLSSEKGPSLSSGLSLPVHPDVLDESCMFEVSTNLPLSKDNVCSVEKSKPCVSSILLEDL
Sbjct: 1381 LLSSEKGPSLSSGLSLPVHPDVLDESCMFEVSTNLPLSKDNVCSVEKSKPCVSSILLEDL 1440

Query: 1441 AVSLTVPSPLKSDGHLSFLKPDMSSSSTPEEVISAHFSEDALLEEEDASEQDIHLALESD 1500
            AVSLTVPSPLKSDGHLSFLKPDMSSSSTPEEVISAHFSEDALLEEEDASEQDIHLALESD
Sbjct: 1441 AVSLTVPSPLKSDGHLSFLKPDMSSSSTPEEVISAHFSEDALLEEEDASEQDIHLALESD 1500

Query: 1501 NSSSKSSCSSSWTSRSVAPGFQYHPNLPMHAVIMEKSNDHFIVKIRRATPSTSSGLKQSM 1560
            NSSSKSSCSSSWTSRSVAPGFQYHPNLPMHAVIMEKSNDHFIVKIRRATPSTSSGLKQSM
Sbjct: 1501 NSSSKSSCSSSWTSRSVAPGFQYHPNLPMHAVIMEKSNDHFIVKIRRATPSTSSGLKQSM 1560

Query: 1561 MPDELLTSLPRHGKEADEGPEKEYISCQNTVFKSVEELENSNKNVDGSKSTHEEQSSMIQ 1620
            MPDELLTSLPRHGKEADEGPEKEYISCQNTVFKSVEELENSNKNVDGSKSTHEEQSSMIQ
Sbjct: 1561 MPDELLTSLPRHGKEADEGPEKEYISCQNTVFKSVEELENSNKNVDGSKSTHEEQSSMIQ 1620

Query: 1621 TQVPDIYEFLKDASDKMGHSDEVADECFKLHQVWETKVPESIEELPSMEEISHSVGEHLP 1680
            TQVPDIYEFLKDASDKMGHSDEVADECFKLHQVWETKVPESIEELPSMEEISHSVGEHLP
Sbjct: 1621 TQVPDIYEFLKDASDKMGHSDEVADECFKLHQVWETKVPESIEELPSMEEISHSVGEHLP 1680

Query: 1681 NTYVDLTKDPVTETKNLGEFIEVTVLHIDQLGCSGGNLNQSAQILDNSLQADTVGAFIDL 1740
            NTYVDLTKDPVTETKNLGEFIEVTVLHIDQLGCSGGNLNQSAQILDNSLQADTVGAFIDL
Sbjct: 1681 NTYVDLTKDPVTETKNLGEFIEVTVLHIDQLGCSGGNLNQSAQILDNSLQADTVGAFIDL 1740

Query: 1741 TQDASSEAKSEGNHPALAVEDLGCGVIQVDEDNCKEEKAQVANRPLKCIVEETYIDLTTE 1800
            TQDASSEAKSEGNHPALAVEDLGCGVIQVDEDNCKEEKAQVANRPLKCIVEETYIDLTTE
Sbjct: 1741 TQDASSEAKSEGNHPALAVEDLGCGVIQVDEDNCKEEKAQVANRPLKCIVEETYIDLTTE 1800

Query: 1801 SPSSCEVKKDELKSEPGSNCDNSELPGTLHNSHKKRRNISDLNHPHKKQRKETDLTNKEK 1860
            SPSSCEVKKDELKSEPGSNCDNSELPGTLHNSHKKRRNISDLNHPHKKQRKETDLTNKEK
Sbjct: 1801 SPSSCEVKKDELKSEPGSNCDNSELPGTLHNSHKKRRNISDLNHPHKKQRKETDLTNKEK 1860

Query: 1861 TKKPTQDSCENTEAHQKKASKKKAPPVTKDPSSLKATPGIKDSSAALATSTSLSAKNVIK 1920
            TKKPTQDSCENTEAHQKKASKKKAPPVTKDPSSLKATPGIKDSSAALATSTSLSAKNVIK
Sbjct: 1861 TKKPTQDSCENTEAHQKKASKKKAPPVTKDPSSLKATPGIKDSSAALATSTSLSAKNVIK 1920

Query: 1921 KKGEIIILWTRNDDREILLECQKRGPSFKTFAYLAAKLDKNPNQVSERFQQLMKLFEKSK 1980
            KKGEIIILWTRNDDREILLECQKRGPSFKTFAYLAAKLDKNPNQVSERFQQLMKLFEKSK
Sbjct: 1921 KKGEIIILWTRNDDREILLECQKRGPSFKTFAYLAAKLDKNPNQVSERFQQLMKLFEKSK 1980

Query: 1981 CR 1982
            CR
Sbjct: 1981 CR 1982


>gi|6912288 caspase 8 associated protein 2 [Homo sapiens]
          Length = 1982

 Score = 3954 bits (10253), Expect = 0.0
 Identities = 1982/1982 (100%), Positives = 1982/1982 (100%)

Query: 1    MAADDDNGDGTSLFDVFSASPLKNNDEGSLDIYAGLDSAVSDSASKSCVPSRNCLDLYEE 60
            MAADDDNGDGTSLFDVFSASPLKNNDEGSLDIYAGLDSAVSDSASKSCVPSRNCLDLYEE
Sbjct: 1    MAADDDNGDGTSLFDVFSASPLKNNDEGSLDIYAGLDSAVSDSASKSCVPSRNCLDLYEE 60

Query: 61   ILTEEGTAKEATYNDLQVEYGKCQLQMKELMKKFKEIQTQNFSLINENQSLKKNISALIK 120
            ILTEEGTAKEATYNDLQVEYGKCQLQMKELMKKFKEIQTQNFSLINENQSLKKNISALIK
Sbjct: 61   ILTEEGTAKEATYNDLQVEYGKCQLQMKELMKKFKEIQTQNFSLINENQSLKKNISALIK 120

Query: 121  TARVEINRKDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHR 180
            TARVEINRKDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHR
Sbjct: 121  TARVEINRKDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHR 180

Query: 181  AKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSN 240
            AKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSN
Sbjct: 181  AKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSN 240

Query: 241  EDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTES 300
            EDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTES
Sbjct: 241  EDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTES 300

Query: 301  KSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKS 360
            KSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKS
Sbjct: 301  KSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKS 360

Query: 361  QDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRD 420
            QDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRD
Sbjct: 361  QDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRD 420

Query: 421  KSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESK 480
            KSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESK
Sbjct: 421  KSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESK 480

Query: 481  EENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAM 540
            EENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAM
Sbjct: 481  EENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAM 540

Query: 541  KAESGPNETKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITDIPKSSGVCDSESSMQV 600
            KAESGPNETKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITDIPKSSGVCDSESSMQV
Sbjct: 541  KAESGPNETKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITDIPKSSGVCDSESSMQV 600

Query: 601  KTVAYVPSISEHILGEAAVSEHTMGETKSTLLEPKVALLAVTEPRIGISETNKEDENSLL 660
            KTVAYVPSISEHILGEAAVSEHTMGETKSTLLEPKVALLAVTEPRIGISETNKEDENSLL
Sbjct: 601  KTVAYVPSISEHILGEAAVSEHTMGETKSTLLEPKVALLAVTEPRIGISETNKEDENSLL 660

Query: 661  VRSVDNTMHCEEPICGTETSFPSPMEIQQTESLFPSTGMKQTINNGRAAAPVVMDVLQTD 720
            VRSVDNTMHCEEPICGTETSFPSPMEIQQTESLFPSTGMKQTINNGRAAAPVVMDVLQTD
Sbjct: 661  VRSVDNTMHCEEPICGTETSFPSPMEIQQTESLFPSTGMKQTINNGRAAAPVVMDVLQTD 720

Query: 721  VSQNFGLELDTKRNDNSDYCGISEGMEMKVALSTTVSETTESILQPSIEEADILPIMLSE 780
            VSQNFGLELDTKRNDNSDYCGISEGMEMKVALSTTVSETTESILQPSIEEADILPIMLSE
Sbjct: 721  VSQNFGLELDTKRNDNSDYCGISEGMEMKVALSTTVSETTESILQPSIEEADILPIMLSE 780

Query: 781  DNNPKFEPSVIVTPLVESKSCHLEPCLPKETLDSSLQQTELMDHRMATGETNSVYHDDDN 840
            DNNPKFEPSVIVTPLVESKSCHLEPCLPKETLDSSLQQTELMDHRMATGETNSVYHDDDN
Sbjct: 781  DNNPKFEPSVIVTPLVESKSCHLEPCLPKETLDSSLQQTELMDHRMATGETNSVYHDDDN 840

Query: 841  SVLSIDLNHLRPIPEAISPLNSPVRPVAKVLRNESPPQVPVYNNSHKDVFLPNSAHSTSK 900
            SVLSIDLNHLRPIPEAISPLNSPVRPVAKVLRNESPPQVPVYNNSHKDVFLPNSAHSTSK
Sbjct: 841  SVLSIDLNHLRPIPEAISPLNSPVRPVAKVLRNESPPQVPVYNNSHKDVFLPNSAHSTSK 900

Query: 901  SQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKNSKRRVS 960
            SQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKNSKRRVS
Sbjct: 901  SQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKNSKRRVS 960

Query: 961  ADVRKSKTIPRRGKSTVCLDKDSRKTHVRIHQTNNKWNKRPDKSSRSSKTEKKDKVMSTS 1020
            ADVRKSKTIPRRGKSTVCLDKDSRKTHVRIHQTNNKWNKRPDKSSRSSKTEKKDKVMSTS
Sbjct: 961  ADVRKSKTIPRRGKSTVCLDKDSRKTHVRIHQTNNKWNKRPDKSSRSSKTEKKDKVMSTS 1020

Query: 1021 SLEKIVPIIAVPSSEQEIMHMLRMIRKHVRKNYMKFKAKFSLIQFHRIIESAILSFTSLI 1080
            SLEKIVPIIAVPSSEQEIMHMLRMIRKHVRKNYMKFKAKFSLIQFHRIIESAILSFTSLI
Sbjct: 1021 SLEKIVPIIAVPSSEQEIMHMLRMIRKHVRKNYMKFKAKFSLIQFHRIIESAILSFTSLI 1080

Query: 1081 KHLNLHKISKSVTTLQKNLCDIIESKLKQVKKNGIVDRLFEQQLPDMKKKLWKFVDDQLD 1140
            KHLNLHKISKSVTTLQKNLCDIIESKLKQVKKNGIVDRLFEQQLPDMKKKLWKFVDDQLD
Sbjct: 1081 KHLNLHKISKSVTTLQKNLCDIIESKLKQVKKNGIVDRLFEQQLPDMKKKLWKFVDDQLD 1140

Query: 1141 YLFAKLKKILVCDSKSFGRDSDEGKLEKTSKQNAQYSNSQKRSVDNSNRELLKEKLSKSE 1200
            YLFAKLKKILVCDSKSFGRDSDEGKLEKTSKQNAQYSNSQKRSVDNSNRELLKEKLSKSE
Sbjct: 1141 YLFAKLKKILVCDSKSFGRDSDEGKLEKTSKQNAQYSNSQKRSVDNSNRELLKEKLSKSE 1200

Query: 1201 DPVHYKSLVGCKKSEENYQDQNNSSINTVKHDIKKNFNICFDNIKNSQSEERSLEVHCPS 1260
            DPVHYKSLVGCKKSEENYQDQNNSSINTVKHDIKKNFNICFDNIKNSQSEERSLEVHCPS
Sbjct: 1201 DPVHYKSLVGCKKSEENYQDQNNSSINTVKHDIKKNFNICFDNIKNSQSEERSLEVHCPS 1260

Query: 1261 TPKSEKNEGSSIEDAQTSQHATLKPERSFEILTEQQASSLTFNLVSDAQMGEIFKSLLQG 1320
            TPKSEKNEGSSIEDAQTSQHATLKPERSFEILTEQQASSLTFNLVSDAQMGEIFKSLLQG
Sbjct: 1261 TPKSEKNEGSSIEDAQTSQHATLKPERSFEILTEQQASSLTFNLVSDAQMGEIFKSLLQG 1320

Query: 1321 SDLLDSSVNCTEKSEWELKTPEKQLLETLKCESIPACTTEELVSGVASPCPKMISDDNWS 1380
            SDLLDSSVNCTEKSEWELKTPEKQLLETLKCESIPACTTEELVSGVASPCPKMISDDNWS
Sbjct: 1321 SDLLDSSVNCTEKSEWELKTPEKQLLETLKCESIPACTTEELVSGVASPCPKMISDDNWS 1380

Query: 1381 LLSSEKGPSLSSGLSLPVHPDVLDESCMFEVSTNLPLSKDNVCSVEKSKPCVSSILLEDL 1440
            LLSSEKGPSLSSGLSLPVHPDVLDESCMFEVSTNLPLSKDNVCSVEKSKPCVSSILLEDL
Sbjct: 1381 LLSSEKGPSLSSGLSLPVHPDVLDESCMFEVSTNLPLSKDNVCSVEKSKPCVSSILLEDL 1440

Query: 1441 AVSLTVPSPLKSDGHLSFLKPDMSSSSTPEEVISAHFSEDALLEEEDASEQDIHLALESD 1500
            AVSLTVPSPLKSDGHLSFLKPDMSSSSTPEEVISAHFSEDALLEEEDASEQDIHLALESD
Sbjct: 1441 AVSLTVPSPLKSDGHLSFLKPDMSSSSTPEEVISAHFSEDALLEEEDASEQDIHLALESD 1500

Query: 1501 NSSSKSSCSSSWTSRSVAPGFQYHPNLPMHAVIMEKSNDHFIVKIRRATPSTSSGLKQSM 1560
            NSSSKSSCSSSWTSRSVAPGFQYHPNLPMHAVIMEKSNDHFIVKIRRATPSTSSGLKQSM
Sbjct: 1501 NSSSKSSCSSSWTSRSVAPGFQYHPNLPMHAVIMEKSNDHFIVKIRRATPSTSSGLKQSM 1560

Query: 1561 MPDELLTSLPRHGKEADEGPEKEYISCQNTVFKSVEELENSNKNVDGSKSTHEEQSSMIQ 1620
            MPDELLTSLPRHGKEADEGPEKEYISCQNTVFKSVEELENSNKNVDGSKSTHEEQSSMIQ
Sbjct: 1561 MPDELLTSLPRHGKEADEGPEKEYISCQNTVFKSVEELENSNKNVDGSKSTHEEQSSMIQ 1620

Query: 1621 TQVPDIYEFLKDASDKMGHSDEVADECFKLHQVWETKVPESIEELPSMEEISHSVGEHLP 1680
            TQVPDIYEFLKDASDKMGHSDEVADECFKLHQVWETKVPESIEELPSMEEISHSVGEHLP
Sbjct: 1621 TQVPDIYEFLKDASDKMGHSDEVADECFKLHQVWETKVPESIEELPSMEEISHSVGEHLP 1680

Query: 1681 NTYVDLTKDPVTETKNLGEFIEVTVLHIDQLGCSGGNLNQSAQILDNSLQADTVGAFIDL 1740
            NTYVDLTKDPVTETKNLGEFIEVTVLHIDQLGCSGGNLNQSAQILDNSLQADTVGAFIDL
Sbjct: 1681 NTYVDLTKDPVTETKNLGEFIEVTVLHIDQLGCSGGNLNQSAQILDNSLQADTVGAFIDL 1740

Query: 1741 TQDASSEAKSEGNHPALAVEDLGCGVIQVDEDNCKEEKAQVANRPLKCIVEETYIDLTTE 1800
            TQDASSEAKSEGNHPALAVEDLGCGVIQVDEDNCKEEKAQVANRPLKCIVEETYIDLTTE
Sbjct: 1741 TQDASSEAKSEGNHPALAVEDLGCGVIQVDEDNCKEEKAQVANRPLKCIVEETYIDLTTE 1800

Query: 1801 SPSSCEVKKDELKSEPGSNCDNSELPGTLHNSHKKRRNISDLNHPHKKQRKETDLTNKEK 1860
            SPSSCEVKKDELKSEPGSNCDNSELPGTLHNSHKKRRNISDLNHPHKKQRKETDLTNKEK
Sbjct: 1801 SPSSCEVKKDELKSEPGSNCDNSELPGTLHNSHKKRRNISDLNHPHKKQRKETDLTNKEK 1860

Query: 1861 TKKPTQDSCENTEAHQKKASKKKAPPVTKDPSSLKATPGIKDSSAALATSTSLSAKNVIK 1920
            TKKPTQDSCENTEAHQKKASKKKAPPVTKDPSSLKATPGIKDSSAALATSTSLSAKNVIK
Sbjct: 1861 TKKPTQDSCENTEAHQKKASKKKAPPVTKDPSSLKATPGIKDSSAALATSTSLSAKNVIK 1920

Query: 1921 KKGEIIILWTRNDDREILLECQKRGPSFKTFAYLAAKLDKNPNQVSERFQQLMKLFEKSK 1980
            KKGEIIILWTRNDDREILLECQKRGPSFKTFAYLAAKLDKNPNQVSERFQQLMKLFEKSK
Sbjct: 1921 KKGEIIILWTRNDDREILLECQKRGPSFKTFAYLAAKLDKNPNQVSERFQQLMKLFEKSK 1980

Query: 1981 CR 1982
            CR
Sbjct: 1981 CR 1982


>gi|212549532 caspase 8 associated protein 2 [Homo sapiens]
          Length = 1982

 Score = 3954 bits (10253), Expect = 0.0
 Identities = 1982/1982 (100%), Positives = 1982/1982 (100%)

Query: 1    MAADDDNGDGTSLFDVFSASPLKNNDEGSLDIYAGLDSAVSDSASKSCVPSRNCLDLYEE 60
            MAADDDNGDGTSLFDVFSASPLKNNDEGSLDIYAGLDSAVSDSASKSCVPSRNCLDLYEE
Sbjct: 1    MAADDDNGDGTSLFDVFSASPLKNNDEGSLDIYAGLDSAVSDSASKSCVPSRNCLDLYEE 60

Query: 61   ILTEEGTAKEATYNDLQVEYGKCQLQMKELMKKFKEIQTQNFSLINENQSLKKNISALIK 120
            ILTEEGTAKEATYNDLQVEYGKCQLQMKELMKKFKEIQTQNFSLINENQSLKKNISALIK
Sbjct: 61   ILTEEGTAKEATYNDLQVEYGKCQLQMKELMKKFKEIQTQNFSLINENQSLKKNISALIK 120

Query: 121  TARVEINRKDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHR 180
            TARVEINRKDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHR
Sbjct: 121  TARVEINRKDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHR 180

Query: 181  AKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSN 240
            AKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSN
Sbjct: 181  AKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSN 240

Query: 241  EDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTES 300
            EDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTES
Sbjct: 241  EDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTES 300

Query: 301  KSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKS 360
            KSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKS
Sbjct: 301  KSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKS 360

Query: 361  QDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRD 420
            QDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRD
Sbjct: 361  QDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRD 420

Query: 421  KSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESK 480
            KSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESK
Sbjct: 421  KSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESK 480

Query: 481  EENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAM 540
            EENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAM
Sbjct: 481  EENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAM 540

Query: 541  KAESGPNETKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITDIPKSSGVCDSESSMQV 600
            KAESGPNETKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITDIPKSSGVCDSESSMQV
Sbjct: 541  KAESGPNETKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITDIPKSSGVCDSESSMQV 600

Query: 601  KTVAYVPSISEHILGEAAVSEHTMGETKSTLLEPKVALLAVTEPRIGISETNKEDENSLL 660
            KTVAYVPSISEHILGEAAVSEHTMGETKSTLLEPKVALLAVTEPRIGISETNKEDENSLL
Sbjct: 601  KTVAYVPSISEHILGEAAVSEHTMGETKSTLLEPKVALLAVTEPRIGISETNKEDENSLL 660

Query: 661  VRSVDNTMHCEEPICGTETSFPSPMEIQQTESLFPSTGMKQTINNGRAAAPVVMDVLQTD 720
            VRSVDNTMHCEEPICGTETSFPSPMEIQQTESLFPSTGMKQTINNGRAAAPVVMDVLQTD
Sbjct: 661  VRSVDNTMHCEEPICGTETSFPSPMEIQQTESLFPSTGMKQTINNGRAAAPVVMDVLQTD 720

Query: 721  VSQNFGLELDTKRNDNSDYCGISEGMEMKVALSTTVSETTESILQPSIEEADILPIMLSE 780
            VSQNFGLELDTKRNDNSDYCGISEGMEMKVALSTTVSETTESILQPSIEEADILPIMLSE
Sbjct: 721  VSQNFGLELDTKRNDNSDYCGISEGMEMKVALSTTVSETTESILQPSIEEADILPIMLSE 780

Query: 781  DNNPKFEPSVIVTPLVESKSCHLEPCLPKETLDSSLQQTELMDHRMATGETNSVYHDDDN 840
            DNNPKFEPSVIVTPLVESKSCHLEPCLPKETLDSSLQQTELMDHRMATGETNSVYHDDDN
Sbjct: 781  DNNPKFEPSVIVTPLVESKSCHLEPCLPKETLDSSLQQTELMDHRMATGETNSVYHDDDN 840

Query: 841  SVLSIDLNHLRPIPEAISPLNSPVRPVAKVLRNESPPQVPVYNNSHKDVFLPNSAHSTSK 900
            SVLSIDLNHLRPIPEAISPLNSPVRPVAKVLRNESPPQVPVYNNSHKDVFLPNSAHSTSK
Sbjct: 841  SVLSIDLNHLRPIPEAISPLNSPVRPVAKVLRNESPPQVPVYNNSHKDVFLPNSAHSTSK 900

Query: 901  SQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKNSKRRVS 960
            SQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKNSKRRVS
Sbjct: 901  SQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKNSKRRVS 960

Query: 961  ADVRKSKTIPRRGKSTVCLDKDSRKTHVRIHQTNNKWNKRPDKSSRSSKTEKKDKVMSTS 1020
            ADVRKSKTIPRRGKSTVCLDKDSRKTHVRIHQTNNKWNKRPDKSSRSSKTEKKDKVMSTS
Sbjct: 961  ADVRKSKTIPRRGKSTVCLDKDSRKTHVRIHQTNNKWNKRPDKSSRSSKTEKKDKVMSTS 1020

Query: 1021 SLEKIVPIIAVPSSEQEIMHMLRMIRKHVRKNYMKFKAKFSLIQFHRIIESAILSFTSLI 1080
            SLEKIVPIIAVPSSEQEIMHMLRMIRKHVRKNYMKFKAKFSLIQFHRIIESAILSFTSLI
Sbjct: 1021 SLEKIVPIIAVPSSEQEIMHMLRMIRKHVRKNYMKFKAKFSLIQFHRIIESAILSFTSLI 1080

Query: 1081 KHLNLHKISKSVTTLQKNLCDIIESKLKQVKKNGIVDRLFEQQLPDMKKKLWKFVDDQLD 1140
            KHLNLHKISKSVTTLQKNLCDIIESKLKQVKKNGIVDRLFEQQLPDMKKKLWKFVDDQLD
Sbjct: 1081 KHLNLHKISKSVTTLQKNLCDIIESKLKQVKKNGIVDRLFEQQLPDMKKKLWKFVDDQLD 1140

Query: 1141 YLFAKLKKILVCDSKSFGRDSDEGKLEKTSKQNAQYSNSQKRSVDNSNRELLKEKLSKSE 1200
            YLFAKLKKILVCDSKSFGRDSDEGKLEKTSKQNAQYSNSQKRSVDNSNRELLKEKLSKSE
Sbjct: 1141 YLFAKLKKILVCDSKSFGRDSDEGKLEKTSKQNAQYSNSQKRSVDNSNRELLKEKLSKSE 1200

Query: 1201 DPVHYKSLVGCKKSEENYQDQNNSSINTVKHDIKKNFNICFDNIKNSQSEERSLEVHCPS 1260
            DPVHYKSLVGCKKSEENYQDQNNSSINTVKHDIKKNFNICFDNIKNSQSEERSLEVHCPS
Sbjct: 1201 DPVHYKSLVGCKKSEENYQDQNNSSINTVKHDIKKNFNICFDNIKNSQSEERSLEVHCPS 1260

Query: 1261 TPKSEKNEGSSIEDAQTSQHATLKPERSFEILTEQQASSLTFNLVSDAQMGEIFKSLLQG 1320
            TPKSEKNEGSSIEDAQTSQHATLKPERSFEILTEQQASSLTFNLVSDAQMGEIFKSLLQG
Sbjct: 1261 TPKSEKNEGSSIEDAQTSQHATLKPERSFEILTEQQASSLTFNLVSDAQMGEIFKSLLQG 1320

Query: 1321 SDLLDSSVNCTEKSEWELKTPEKQLLETLKCESIPACTTEELVSGVASPCPKMISDDNWS 1380
            SDLLDSSVNCTEKSEWELKTPEKQLLETLKCESIPACTTEELVSGVASPCPKMISDDNWS
Sbjct: 1321 SDLLDSSVNCTEKSEWELKTPEKQLLETLKCESIPACTTEELVSGVASPCPKMISDDNWS 1380

Query: 1381 LLSSEKGPSLSSGLSLPVHPDVLDESCMFEVSTNLPLSKDNVCSVEKSKPCVSSILLEDL 1440
            LLSSEKGPSLSSGLSLPVHPDVLDESCMFEVSTNLPLSKDNVCSVEKSKPCVSSILLEDL
Sbjct: 1381 LLSSEKGPSLSSGLSLPVHPDVLDESCMFEVSTNLPLSKDNVCSVEKSKPCVSSILLEDL 1440

Query: 1441 AVSLTVPSPLKSDGHLSFLKPDMSSSSTPEEVISAHFSEDALLEEEDASEQDIHLALESD 1500
            AVSLTVPSPLKSDGHLSFLKPDMSSSSTPEEVISAHFSEDALLEEEDASEQDIHLALESD
Sbjct: 1441 AVSLTVPSPLKSDGHLSFLKPDMSSSSTPEEVISAHFSEDALLEEEDASEQDIHLALESD 1500

Query: 1501 NSSSKSSCSSSWTSRSVAPGFQYHPNLPMHAVIMEKSNDHFIVKIRRATPSTSSGLKQSM 1560
            NSSSKSSCSSSWTSRSVAPGFQYHPNLPMHAVIMEKSNDHFIVKIRRATPSTSSGLKQSM
Sbjct: 1501 NSSSKSSCSSSWTSRSVAPGFQYHPNLPMHAVIMEKSNDHFIVKIRRATPSTSSGLKQSM 1560

Query: 1561 MPDELLTSLPRHGKEADEGPEKEYISCQNTVFKSVEELENSNKNVDGSKSTHEEQSSMIQ 1620
            MPDELLTSLPRHGKEADEGPEKEYISCQNTVFKSVEELENSNKNVDGSKSTHEEQSSMIQ
Sbjct: 1561 MPDELLTSLPRHGKEADEGPEKEYISCQNTVFKSVEELENSNKNVDGSKSTHEEQSSMIQ 1620

Query: 1621 TQVPDIYEFLKDASDKMGHSDEVADECFKLHQVWETKVPESIEELPSMEEISHSVGEHLP 1680
            TQVPDIYEFLKDASDKMGHSDEVADECFKLHQVWETKVPESIEELPSMEEISHSVGEHLP
Sbjct: 1621 TQVPDIYEFLKDASDKMGHSDEVADECFKLHQVWETKVPESIEELPSMEEISHSVGEHLP 1680

Query: 1681 NTYVDLTKDPVTETKNLGEFIEVTVLHIDQLGCSGGNLNQSAQILDNSLQADTVGAFIDL 1740
            NTYVDLTKDPVTETKNLGEFIEVTVLHIDQLGCSGGNLNQSAQILDNSLQADTVGAFIDL
Sbjct: 1681 NTYVDLTKDPVTETKNLGEFIEVTVLHIDQLGCSGGNLNQSAQILDNSLQADTVGAFIDL 1740

Query: 1741 TQDASSEAKSEGNHPALAVEDLGCGVIQVDEDNCKEEKAQVANRPLKCIVEETYIDLTTE 1800
            TQDASSEAKSEGNHPALAVEDLGCGVIQVDEDNCKEEKAQVANRPLKCIVEETYIDLTTE
Sbjct: 1741 TQDASSEAKSEGNHPALAVEDLGCGVIQVDEDNCKEEKAQVANRPLKCIVEETYIDLTTE 1800

Query: 1801 SPSSCEVKKDELKSEPGSNCDNSELPGTLHNSHKKRRNISDLNHPHKKQRKETDLTNKEK 1860
            SPSSCEVKKDELKSEPGSNCDNSELPGTLHNSHKKRRNISDLNHPHKKQRKETDLTNKEK
Sbjct: 1801 SPSSCEVKKDELKSEPGSNCDNSELPGTLHNSHKKRRNISDLNHPHKKQRKETDLTNKEK 1860

Query: 1861 TKKPTQDSCENTEAHQKKASKKKAPPVTKDPSSLKATPGIKDSSAALATSTSLSAKNVIK 1920
            TKKPTQDSCENTEAHQKKASKKKAPPVTKDPSSLKATPGIKDSSAALATSTSLSAKNVIK
Sbjct: 1861 TKKPTQDSCENTEAHQKKASKKKAPPVTKDPSSLKATPGIKDSSAALATSTSLSAKNVIK 1920

Query: 1921 KKGEIIILWTRNDDREILLECQKRGPSFKTFAYLAAKLDKNPNQVSERFQQLMKLFEKSK 1980
            KKGEIIILWTRNDDREILLECQKRGPSFKTFAYLAAKLDKNPNQVSERFQQLMKLFEKSK
Sbjct: 1921 KKGEIIILWTRNDDREILLECQKRGPSFKTFAYLAAKLDKNPNQVSERFQQLMKLFEKSK 1980

Query: 1981 CR 1982
            CR
Sbjct: 1981 CR 1982


>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
          Length = 2039

 Score = 75.9 bits (185), Expect = 4e-13
 Identities = 124/574 (21%), Positives = 241/574 (41%), Gaps = 81/574 (14%)

Query: 94   FKEIQTQNFSLINENQSLKKNISALIKTARVEINRKDEEISNLHQRLSEFPHFRNNH--- 150
            FK  +T++  L  E++SL      L K +++E N KD++ S   + +S+  +F+      
Sbjct: 678  FKSDETEDLFLNMEHESL-----TLEKKSKLEKNIKDDK-STKEKHVSKERNFKEERDKI 731

Query: 151  --KTARTFDTVKTKDLKSRSPHLDDCSKTDHRAKSDVSKDVHHSTSLPNLEKEGKPHSDK 208
              ++ ++F   K KDLK    ++   +  D    S     +  S  L  +EKE      +
Sbjct: 732  KKESEKSFREEKIKDLKEERENIP--TDKDSEFTSLGMSAIEESIGLHLVEKE---IDIE 786

Query: 209  RSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRGTERVRKDLST 268
            +   H+  S EK            Q+ E    +  R+  +  +  +    +E+ + DLS 
Sbjct: 787  KQEKHIKESKEK-------PEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSE 839

Query: 269  GCGDGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPG 328
             C D   +I E  +    H EK  K   K+++ ++  K   D +   E+++   +KE P 
Sbjct: 840  -CVD---KIKEKDKLYSHHTEKCHKEGEKSKNTAA-IKKTDDREKSREKMDRKHDKEKPE 894

Query: 329  ERSHSRVDSQSDKKLERQSERSQNIN-RKEVKSQDKE-ERKVDQKPKSVVKDQ------D 380
            +  H   +S+    +E+++++S N    K  K ++KE +R++D+K KS  K+        
Sbjct: 895  KERHL-AESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSK 953

Query: 381  HWRRSERASL------PHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCP 434
            H +  +++S+       H K  ++    +    L+   G E  K+DK ++ +  +D    
Sbjct: 954  HIQEEKKSSIVDGNKAQHEK-PLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERD---- 1008

Query: 435  SSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESKEENRHIRNEKRVPT 494
                     K+ D  +++++       LK +    + K K    SK+       EKR+  
Sbjct: 1009 ---------KHKDKIQINSL-------LKLKSEADKPKPKSSPASKDTRP---KEKRLVN 1049

Query: 495  EHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAMKAESG------PNE 548
            + L +T+ E   +  DL+ +   K  K ++         +   L +K +        P E
Sbjct: 1050 DDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTE 1109

Query: 549  TKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITD------IPKSSGVCDSESSMQVKT 602
            +KNK+L  S   ++    +  K+   +  N+ +  D      + KSS V D+  +   ++
Sbjct: 1110 SKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRS 1169

Query: 603  VAYVPSISEHILG--EAAVSEHTMGETKSTLLEP 634
                P +S   +     A SE +   T +T   P
Sbjct: 1170 ENEKPGLSSRSVSMISVASSEDSCHTTVTTPRPP 1203



 Score = 53.1 bits (126), Expect = 3e-06
 Identities = 100/489 (20%), Positives = 171/489 (34%), Gaps = 83/489 (16%)

Query: 158  TVKTKDLKSRSPHLDDCSKTDHRAKSDVSKDVHHSTSLPN-------LEKEGKPHSDKRS 210
            +VK+   K +S H  D         +   KD  HS +  N       ++KEGK    K  
Sbjct: 573  SVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLK-KHK 631

Query: 211  TSHLPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRGTERVRKDLSTGC 270
              H     EKH       +  Y+  + S+ E  R    D    + N       +DL    
Sbjct: 632  LKHKEREKEKHKKEIEGEKEKYKTKD-SAKELQRSVEFDREFWKENFFKSDETEDLFLNM 690

Query: 271  GDGEPRILEASQRLQGH-------PEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWE 323
             + E   LE   +L+ +        EK+   E   + +  K K  S+  ++ E+I     
Sbjct: 691  -EHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKI----- 744

Query: 324  KETPGERSHSRVDSQSD------------------------KKLERQSERSQNINRKEVK 359
            K+   ER +   D  S+                        +K E+  + S+    K  +
Sbjct: 745  KDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQ 804

Query: 360  SQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSK-------NEITFSHNSSKYHLEERR 412
             ++K+  K+++K     K   H  +SE+  L  S+        +  +SH++ K H E  +
Sbjct: 805  IKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEK 864

Query: 413  GWEDC----------KRDKSVNSHSFQDGRCPSSLSNSRT-------HKNIDSKEVDAMH 455
                            R+K    H  +       L+ S+        +K  D+ E     
Sbjct: 865  SKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSE 924

Query: 456  QWENTPLKAERHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQN 515
            + +N     E  + E  R +E  +   ++HI+ EK+       K   E   +  +  K  
Sbjct: 925  KGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDE 984

Query: 516  EPKTDKGEVLDNGVSEGADNKELAMKAESGPNETK---NKDLKLSFMKKLNLTLSPAKKQ 572
              KT  G+  D        +K++    E   ++ K   N  LKL    K        K  
Sbjct: 985  PLKTPDGKEKDK------KDKDIDRYKERDKHKDKIQINSLLKL----KSEADKPKPKSS 1034

Query: 573  PVSQDNQHK 581
            P S+D + K
Sbjct: 1035 PASKDTRPK 1043



 Score = 38.9 bits (89), Expect = 0.051
 Identities = 82/391 (20%), Positives = 153/391 (39%), Gaps = 72/391 (18%)

Query: 900  KSQSDLNKENQKPIYKSDKCT------EADTCKNSPLDELE------EGEIRSDSETSKP 947
            KS + +  E+  P +++  CT      E  T K   L   E      + EI  + E  K 
Sbjct: 596  KSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKT 655

Query: 948  QESFEKNSKRRVSAD---------------------VRKSKTIPRRGK--STVCLDKDSR 984
            ++S  K  +R V  D                       +S T+ ++ K    +  DK ++
Sbjct: 656  KDS-AKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTK 714

Query: 985  KTHV----RIHQTNNKWNKRPDKSSRSSKTEK-----------KDKVMSTSSLEKIVPII 1029
            + HV       +  +K  K  +KS R  K +            KD   ++  +  I   I
Sbjct: 715  EKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESI 774

Query: 1030 AVPSSEQEIMHMLRMIRKHVRKNYMKFKAKFSLIQFHRIIESAILSFTSLIKHLNLHKIS 1089
             +   E+EI   +    KH++++  K   K S I+   I +    +F    K  + HK  
Sbjct: 775  GLHLVEKEID--IEKQEKHIKESKEK-PEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSE 831

Query: 1090 KSVTTLQKNLCDIIESKLKQVKKNGIVDRLFEQQLPDMKKKLWKFVDDQ---LDYLFAKL 1146
            K    L + + D I+ K K    +   ++  ++          K  DD+    + +  K 
Sbjct: 832  KDKLDLSECV-DKIKEKDKLYSHH--TEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKH 888

Query: 1147 KKILVCDSKSFGRDSDEGKLEKTSKQ--NAQYSNSQKRSVDNSNRELLKEKLSKSEDPVH 1204
             K      +      ++  +EK +KQ  N++YS S+K      +REL K++ S+ ++ ++
Sbjct: 889  DKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESIN 948

Query: 1205 YKSLVGCKKSEENYQDQNNSSI---NTVKHD 1232
                     + ++ Q++  SSI   N  +H+
Sbjct: 949  I-------TNSKHIQEEKKSSIVDGNKAQHE 972



 Score = 34.7 bits (78), Expect = 0.95
 Identities = 90/490 (18%), Positives = 184/490 (37%), Gaps = 76/490 (15%)

Query: 125 EINRK--DEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHRAK 182
           EIN+   D  I    QR    P     H  A+       K  KS+              K
Sbjct: 347 EINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSK--------------K 392

Query: 183 SDVSKDVHHSTSLPNLEK-EGKPHSDKRS----TSHLPTSVEKHCTNGVWSRSHYQVGEG 237
              S+ ++ ST   + E  + K  S   S    TS+     +K     V S  H Q G+ 
Sbjct: 393 QKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEY---VVSGEHKQKGKV 449

Query: 238 S---SNEDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKG 294
                N++  +  ++++  +  +   R+  +L+   G      L+ S++ +         
Sbjct: 450 KRKLKNQNKNKENQELKQEKEGKENTRIT-NLTVNTG------LDCSEKTREEGNFRKSF 502

Query: 295 EPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRV---DSQSDKKLERQSERSQ 351
            PK ++    F  ++    K      S ++ TP ++ H++       S+  L+    R  
Sbjct: 503 SPKDDTSLHLFHISTGKSPK-HSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYD 561

Query: 352 NINR---------KEVKSQDKEERKVD------QKPKSVVKDQDH----------WRRSE 386
           N            K  K ++K + + D      +K  + +KD+DH           ++ +
Sbjct: 562 NTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMD 621

Query: 387 RASLPHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNI 446
           +      K+++       + H +E  G ++  + K       +              K+ 
Sbjct: 622 KEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSD 681

Query: 447 DSKEVDAMHQWENTPL----KAERHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNK 502
           +++++    + E+  L    K E++  +DK  +E+   +E R+ + E+    +  +K+ +
Sbjct: 682 ETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKE-RNFKEERDKIKKESEKSFR 740

Query: 503 ETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADN-------KELAM-KAESGPNETKNKDL 554
           E K      +++N P     E    G+S   ++       KE+ + K E    E+K K  
Sbjct: 741 EEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPE 800

Query: 555 KLSFMKKLNL 564
           K S +K+ ++
Sbjct: 801 KRSQIKEKDI 810


>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
          Length = 2062

 Score = 75.9 bits (185), Expect = 4e-13
 Identities = 124/574 (21%), Positives = 241/574 (41%), Gaps = 81/574 (14%)

Query: 94   FKEIQTQNFSLINENQSLKKNISALIKTARVEINRKDEEISNLHQRLSEFPHFRNNH--- 150
            FK  +T++  L  E++SL      L K +++E N KD++ S   + +S+  +F+      
Sbjct: 701  FKSDETEDLFLNMEHESL-----TLEKKSKLEKNIKDDK-STKEKHVSKERNFKEERDKI 754

Query: 151  --KTARTFDTVKTKDLKSRSPHLDDCSKTDHRAKSDVSKDVHHSTSLPNLEKEGKPHSDK 208
              ++ ++F   K KDLK    ++   +  D    S     +  S  L  +EKE      +
Sbjct: 755  KKESEKSFREEKIKDLKEERENIP--TDKDSEFTSLGMSAIEESIGLHLVEKE---IDIE 809

Query: 209  RSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRGTERVRKDLST 268
            +   H+  S EK            Q+ E    +  R+  +  +  +    +E+ + DLS 
Sbjct: 810  KQEKHIKESKEK-------PEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSE 862

Query: 269  GCGDGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPG 328
             C D   +I E  +    H EK  K   K+++ ++  K   D +   E+++   +KE P 
Sbjct: 863  -CVD---KIKEKDKLYSHHTEKCHKEGEKSKNTAA-IKKTDDREKSREKMDRKHDKEKPE 917

Query: 329  ERSHSRVDSQSDKKLERQSERSQNIN-RKEVKSQDKE-ERKVDQKPKSVVKDQ------D 380
            +  H   +S+    +E+++++S N    K  K ++KE +R++D+K KS  K+        
Sbjct: 918  KERHL-AESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSK 976

Query: 381  HWRRSERASL------PHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCP 434
            H +  +++S+       H K  ++    +    L+   G E  K+DK ++ +  +D    
Sbjct: 977  HIQEEKKSSIVDGNKAQHEK-PLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERD---- 1031

Query: 435  SSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESKEENRHIRNEKRVPT 494
                     K+ D  +++++       LK +    + K K    SK+       EKR+  
Sbjct: 1032 ---------KHKDKIQINSL-------LKLKSEADKPKPKSSPASKDTRP---KEKRLVN 1072

Query: 495  EHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAMKAESG------PNE 548
            + L +T+ E   +  DL+ +   K  K ++         +   L +K +        P E
Sbjct: 1073 DDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTE 1132

Query: 549  TKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITD------IPKSSGVCDSESSMQVKT 602
            +KNK+L  S   ++    +  K+   +  N+ +  D      + KSS V D+  +   ++
Sbjct: 1133 SKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRS 1192

Query: 603  VAYVPSISEHILG--EAAVSEHTMGETKSTLLEP 634
                P +S   +     A SE +   T +T   P
Sbjct: 1193 ENEKPGLSSRSVSMISVASSEDSCHTTVTTPRPP 1226



 Score = 53.1 bits (126), Expect = 3e-06
 Identities = 100/489 (20%), Positives = 171/489 (34%), Gaps = 83/489 (16%)

Query: 158  TVKTKDLKSRSPHLDDCSKTDHRAKSDVSKDVHHSTSLPN-------LEKEGKPHSDKRS 210
            +VK+   K +S H  D         +   KD  HS +  N       ++KEGK    K  
Sbjct: 596  SVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLK-KHK 654

Query: 211  TSHLPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRGTERVRKDLSTGC 270
              H     EKH       +  Y+  + S+ E  R    D    + N       +DL    
Sbjct: 655  LKHKEREKEKHKKEIEGEKEKYKTKD-SAKELQRSVEFDREFWKENFFKSDETEDLFLNM 713

Query: 271  GDGEPRILEASQRLQGH-------PEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWE 323
             + E   LE   +L+ +        EK+   E   + +  K K  S+  ++ E+I     
Sbjct: 714  -EHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKI----- 767

Query: 324  KETPGERSHSRVDSQSD------------------------KKLERQSERSQNINRKEVK 359
            K+   ER +   D  S+                        +K E+  + S+    K  +
Sbjct: 768  KDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQ 827

Query: 360  SQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSK-------NEITFSHNSSKYHLEERR 412
             ++K+  K+++K     K   H  +SE+  L  S+        +  +SH++ K H E  +
Sbjct: 828  IKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEK 887

Query: 413  GWEDC----------KRDKSVNSHSFQDGRCPSSLSNSRT-------HKNIDSKEVDAMH 455
                            R+K    H  +       L+ S+        +K  D+ E     
Sbjct: 888  SKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSE 947

Query: 456  QWENTPLKAERHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQN 515
            + +N     E  + E  R +E  +   ++HI+ EK+       K   E   +  +  K  
Sbjct: 948  KGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDE 1007

Query: 516  EPKTDKGEVLDNGVSEGADNKELAMKAESGPNETK---NKDLKLSFMKKLNLTLSPAKKQ 572
              KT  G+  D        +K++    E   ++ K   N  LKL    K        K  
Sbjct: 1008 PLKTPDGKEKDK------KDKDIDRYKERDKHKDKIQINSLLKL----KSEADKPKPKSS 1057

Query: 573  PVSQDNQHK 581
            P S+D + K
Sbjct: 1058 PASKDTRPK 1066



 Score = 38.9 bits (89), Expect = 0.051
 Identities = 82/391 (20%), Positives = 153/391 (39%), Gaps = 72/391 (18%)

Query: 900  KSQSDLNKENQKPIYKSDKCT------EADTCKNSPLDELE------EGEIRSDSETSKP 947
            KS + +  E+  P +++  CT      E  T K   L   E      + EI  + E  K 
Sbjct: 619  KSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKT 678

Query: 948  QESFEKNSKRRVSAD---------------------VRKSKTIPRRGK--STVCLDKDSR 984
            ++S  K  +R V  D                       +S T+ ++ K    +  DK ++
Sbjct: 679  KDS-AKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTK 737

Query: 985  KTHV----RIHQTNNKWNKRPDKSSRSSKTEK-----------KDKVMSTSSLEKIVPII 1029
            + HV       +  +K  K  +KS R  K +            KD   ++  +  I   I
Sbjct: 738  EKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESI 797

Query: 1030 AVPSSEQEIMHMLRMIRKHVRKNYMKFKAKFSLIQFHRIIESAILSFTSLIKHLNLHKIS 1089
             +   E+EI   +    KH++++  K   K S I+   I +    +F    K  + HK  
Sbjct: 798  GLHLVEKEID--IEKQEKHIKESKEK-PEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSE 854

Query: 1090 KSVTTLQKNLCDIIESKLKQVKKNGIVDRLFEQQLPDMKKKLWKFVDDQ---LDYLFAKL 1146
            K    L + + D I+ K K    +   ++  ++          K  DD+    + +  K 
Sbjct: 855  KDKLDLSECV-DKIKEKDKLYSHH--TEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKH 911

Query: 1147 KKILVCDSKSFGRDSDEGKLEKTSKQ--NAQYSNSQKRSVDNSNRELLKEKLSKSEDPVH 1204
             K      +      ++  +EK +KQ  N++YS S+K      +REL K++ S+ ++ ++
Sbjct: 912  DKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESIN 971

Query: 1205 YKSLVGCKKSEENYQDQNNSSI---NTVKHD 1232
                     + ++ Q++  SSI   N  +H+
Sbjct: 972  I-------TNSKHIQEEKKSSIVDGNKAQHE 995



 Score = 34.7 bits (78), Expect = 0.95
 Identities = 90/490 (18%), Positives = 184/490 (37%), Gaps = 76/490 (15%)

Query: 125 EINRK--DEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHRAK 182
           EIN+   D  I    QR    P     H  A+       K  KS+              K
Sbjct: 370 EINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSK--------------K 415

Query: 183 SDVSKDVHHSTSLPNLEK-EGKPHSDKRS----TSHLPTSVEKHCTNGVWSRSHYQVGEG 237
              S+ ++ ST   + E  + K  S   S    TS+     +K     V S  H Q G+ 
Sbjct: 416 QKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEY---VVSGEHKQKGKV 472

Query: 238 S---SNEDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKG 294
                N++  +  ++++  +  +   R+  +L+   G      L+ S++ +         
Sbjct: 473 KRKLKNQNKNKENQELKQEKEGKENTRIT-NLTVNTG------LDCSEKTREEGNFRKSF 525

Query: 295 EPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRV---DSQSDKKLERQSERSQ 351
            PK ++    F  ++    K      S ++ TP ++ H++       S+  L+    R  
Sbjct: 526 SPKDDTSLHLFHISTGKSPK-HSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYD 584

Query: 352 NINR---------KEVKSQDKEERKVD------QKPKSVVKDQDH----------WRRSE 386
           N            K  K ++K + + D      +K  + +KD+DH           ++ +
Sbjct: 585 NTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMD 644

Query: 387 RASLPHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNI 446
           +      K+++       + H +E  G ++  + K       +              K+ 
Sbjct: 645 KEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSD 704

Query: 447 DSKEVDAMHQWENTPL----KAERHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNK 502
           +++++    + E+  L    K E++  +DK  +E+   +E R+ + E+    +  +K+ +
Sbjct: 705 ETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKE-RNFKEERDKIKKESEKSFR 763

Query: 503 ETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADN-------KELAM-KAESGPNETKNKDL 554
           E K      +++N P     E    G+S   ++       KE+ + K E    E+K K  
Sbjct: 764 EEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPE 823

Query: 555 KLSFMKKLNL 564
           K S +K+ ++
Sbjct: 824 KRSQIKEKDI 833


>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a
           [Homo sapiens]
          Length = 624

 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 82/384 (21%), Positives = 164/384 (42%), Gaps = 33/384 (8%)

Query: 165 KSRSPHLDDCSKTDHRAKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPT---SVEKH 221
           ++ +  L++  K    A+S +S  +   +   N  K G+  S  RS S   +   S  K 
Sbjct: 269 QAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKR 328

Query: 222 CTNGVWSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEAS 281
             +   SRSH +    S  +D RR +    H + ++  ER +    +   D      E  
Sbjct: 329 SQSKHRSRSHNR--SRSRQKDRRRSKSP--HKKRSKSRERRKSRSRSHSRDKRKDTREKI 384

Query: 282 QRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDK 341
           +  +   EK  + E + E +  K K       +G+  +   E+E   E+     D + D+
Sbjct: 385 KEKERVKEKDREKEREREKEREKEKE------RGKNKDRDKEREKDREK-----DKEKDR 433

Query: 342 KLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSH 401
           + ER+ E  ++ ++++ K QDKE+ +   + K +  D+   +  +  + P S N    S 
Sbjct: 434 EREREKEHEKDRDKEKEKEQDKEKEREKDRSKEI--DEKRKKDKKSRTPPRSYNASRRSR 491

Query: 402 NSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTP 461
           +SS+     RR     +  ++  +   +  R PS  S ++  K  + KE D + +     
Sbjct: 492 SSSRER-RRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKRE-KERDHISE----- 544

Query: 462 LKAERHRTEDKRKREQESKEENRHIRNEKRVPT-EHLQKTNKETKKTTTDLKKQNEPKTD 520
            + ER R+   RK   +   + +  +N   +   EH ++ +    K   D   ++ P+T+
Sbjct: 545 -RRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDD---KDAPRTE 600

Query: 521 KGEVLDNGVSEGADNKELAMKAES 544
           + ++  NG  +  + + L+ K E+
Sbjct: 601 ENKIQHNGNCQ-LNEENLSTKTEA 623



 Score = 61.2 bits (147), Expect = 1e-08
 Identities = 62/297 (20%), Positives = 123/297 (41%), Gaps = 14/297 (4%)

Query: 260 ERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERIN 319
           +RVR+  S      EP   ++++R  G    + + + ++ SKS   +  S S ++    N
Sbjct: 280 KRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHN 339

Query: 320 SSWEKETPGERSHSRVDSQSDKKLERQSERSQNIN---RKEVKSQDKEERKVDQKPKSVV 376
            S  ++    RS S    +S K  ER+  RS++ +   RK+ + + KE+ +V +K +   
Sbjct: 340 RSRSRQKDRRRSKSPHKKRS-KSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKE 398

Query: 377 KDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSS 436
           ++++  R  E+      KN+     +  +    E+   +D +R++       +D      
Sbjct: 399 REREKEREKEK---ERGKNK---DRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKE 452

Query: 437 LSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESKEENRHIRNEKRVPTEH 496
               +  +   SKE+D   + +       R     +R R    +   R  R+  R P   
Sbjct: 453 QDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSP--R 510

Query: 497 LQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGAD-NKELAMKAESGPNETKNK 552
             KT K     +   + +N+ K  K E   + +SE  +  +  +M+  S   + K K
Sbjct: 511 TSKTIKRKSSRSPSPRSRNK-KDKKREKERDHISERRERERSTSMRKSSNDRDGKEK 566



 Score = 32.3 bits (72), Expect = 4.7
 Identities = 18/79 (22%), Positives = 34/79 (43%)

Query: 1808 KKDELKSEPGSNCDNSELPGTLHNSHKKRRNISDLNHPHKKQRKETDLTNKEKTKKPTQD 1867
            K+ E + E G N D  +         K++    +    H+K R +     ++K K+  +D
Sbjct: 403  KEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKD 462

Query: 1868 SCENTEAHQKKASKKKAPP 1886
              +  +  +KK  K + PP
Sbjct: 463  RSKEIDEKRKKDKKSRTPP 481



 Score = 31.6 bits (70), Expect = 8.1
 Identities = 26/115 (22%), Positives = 52/115 (45%), Gaps = 4/115 (3%)

Query: 906  NKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKNSKRRVSADVRK 965
            NK+  K   + +K  E D  K+   +  +E E   D E  K Q+  ++  K R S ++ +
Sbjct: 414  NKDRDK---EREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDR-SKEIDE 469

Query: 966  SKTIPRRGKSTVCLDKDSRKTHVRIHQTNNKWNKRPDKSSRSSKTEKKDKVMSTS 1020
             +   ++ ++       SR++     +   + ++   +S R+SKT K+    S S
Sbjct: 470  KRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPS 524


>gi|21040255 splicing factor, arginine/serine-rich 12 isoform b
           [Homo sapiens]
          Length = 508

 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 82/384 (21%), Positives = 164/384 (42%), Gaps = 33/384 (8%)

Query: 165 KSRSPHLDDCSKTDHRAKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPT---SVEKH 221
           ++ +  L++  K    A+S +S  +   +   N  K G+  S  RS S   +   S  K 
Sbjct: 153 QAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKR 212

Query: 222 CTNGVWSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEAS 281
             +   SRSH +    S  +D RR +    H + ++  ER +    +   D      E  
Sbjct: 213 SQSKHRSRSHNR--SRSRQKDRRRSKSP--HKKRSKSRERRKSRSRSHSRDKRKDTREKI 268

Query: 282 QRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDK 341
           +  +   EK  + E + E +  K K       +G+  +   E+E   E+     D + D+
Sbjct: 269 KEKERVKEKDREKEREREKEREKEKE------RGKNKDRDKEREKDREK-----DKEKDR 317

Query: 342 KLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSH 401
           + ER+ E  ++ ++++ K QDKE+ +   + K +  D+   +  +  + P S N    S 
Sbjct: 318 EREREKEHEKDRDKEKEKEQDKEKEREKDRSKEI--DEKRKKDKKSRTPPRSYNASRRSR 375

Query: 402 NSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTP 461
           +SS+     RR     +  ++  +   +  R PS  S ++  K  + KE D + +     
Sbjct: 376 SSSRER-RRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKRE-KERDHISE----- 428

Query: 462 LKAERHRTEDKRKREQESKEENRHIRNEKRVPT-EHLQKTNKETKKTTTDLKKQNEPKTD 520
            + ER R+   RK   +   + +  +N   +   EH ++ +    K   D   ++ P+T+
Sbjct: 429 -RRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDD---KDAPRTE 484

Query: 521 KGEVLDNGVSEGADNKELAMKAES 544
           + ++  NG  +  + + L+ K E+
Sbjct: 485 ENKIQHNGNCQ-LNEENLSTKTEA 507



 Score = 61.2 bits (147), Expect = 1e-08
 Identities = 62/297 (20%), Positives = 123/297 (41%), Gaps = 14/297 (4%)

Query: 260 ERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERIN 319
           +RVR+  S      EP   ++++R  G    + + + ++ SKS   +  S S ++    N
Sbjct: 164 KRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHN 223

Query: 320 SSWEKETPGERSHSRVDSQSDKKLERQSERSQNIN---RKEVKSQDKEERKVDQKPKSVV 376
            S  ++    RS S    +S K  ER+  RS++ +   RK+ + + KE+ +V +K +   
Sbjct: 224 RSRSRQKDRRRSKSPHKKRS-KSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKE 282

Query: 377 KDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSS 436
           ++++  R  E+      KN+     +  +    E+   +D +R++       +D      
Sbjct: 283 REREKEREKEK---ERGKNK---DRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKE 336

Query: 437 LSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESKEENRHIRNEKRVPTEH 496
               +  +   SKE+D   + +       R     +R R    +   R  R+  R P   
Sbjct: 337 QDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSP--R 394

Query: 497 LQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGAD-NKELAMKAESGPNETKNK 552
             KT K     +   + +N+ K  K E   + +SE  +  +  +M+  S   + K K
Sbjct: 395 TSKTIKRKSSRSPSPRSRNK-KDKKREKERDHISERRERERSTSMRKSSNDRDGKEK 450



 Score = 32.3 bits (72), Expect = 4.7
 Identities = 18/79 (22%), Positives = 34/79 (43%)

Query: 1808 KKDELKSEPGSNCDNSELPGTLHNSHKKRRNISDLNHPHKKQRKETDLTNKEKTKKPTQD 1867
            K+ E + E G N D  +         K++    +    H+K R +     ++K K+  +D
Sbjct: 287  KEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKD 346

Query: 1868 SCENTEAHQKKASKKKAPP 1886
              +  +  +KK  K + PP
Sbjct: 347  RSKEIDEKRKKDKKSRTPP 365



 Score = 31.6 bits (70), Expect = 8.1
 Identities = 26/115 (22%), Positives = 52/115 (45%), Gaps = 4/115 (3%)

Query: 906  NKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKNSKRRVSADVRK 965
            NK+  K   + +K  E D  K+   +  +E E   D E  K Q+  ++  K R S ++ +
Sbjct: 298  NKDRDK---EREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDR-SKEIDE 353

Query: 966  SKTIPRRGKSTVCLDKDSRKTHVRIHQTNNKWNKRPDKSSRSSKTEKKDKVMSTS 1020
             +   ++ ++       SR++     +   + ++   +S R+SKT K+    S S
Sbjct: 354  KRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPS 408


>gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]
          Length = 494

 Score = 62.4 bits (150), Expect = 4e-09
 Identities = 72/342 (21%), Positives = 140/342 (40%), Gaps = 40/342 (11%)

Query: 242 DSRRGRKD------IRHSQFNRGTERVRKDLSTGCGDGEPRILE---ASQRLQGHPEKYG 292
           D+ +GRK+      + +S   R  E++     T     + R++E    S+R + +     
Sbjct: 134 DAHKGRKNEGVIEFVSYSDMKRALEKLD---GTEVNGRKIRLVEDKPGSRRRRSYSRSRS 190

Query: 293 KGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQN 352
               ++ S+ S+ KS S S       + S  +   G RS S+  S+S  +   + E+S++
Sbjct: 191 HSRSRSRSRHSR-KSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRSRSQSRSRSKKEKSRS 249

Query: 353 INRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERR 412
            ++++ +S+     K   K K   +++   + ++    P S++       S      + R
Sbjct: 250 PSKEKSRSRSHSAGKSRSKSKDQAEEKI--QNNDNVGKPKSRSPSRHKSKSKSRSRSQER 307

Query: 413 GWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDK 472
             E+ KR  SV+    Q+     S S SR+     S+                R +++DK
Sbjct: 308 RVEEEKRG-SVSRGRSQEKSLRQSRSRSRSKGGSRSRS-------------RSRSKSKDK 353

Query: 473 RKREQESKEENRHIRNEKRVPTEHLQK----------TNKETKKTTTDLKKQNEPKTDKG 522
           RK  + S+EE+R  R+  R  +E  +K          ++K+ KK  TD  +   P     
Sbjct: 354 RKGRKRSREESRS-RSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVS 412

Query: 523 EVLDNGVSEGADNKELAMKAESGPNETKNKDLKLSFMKKLNL 564
           +  ++  SE +  +       +G N+      + +   K NL
Sbjct: 413 KEREHAKSESSQREGRGESENAGTNQETRSRSRSNSKSKPNL 454



 Score = 45.8 bits (107), Expect = 4e-04
 Identities = 62/269 (23%), Positives = 104/269 (38%), Gaps = 47/269 (17%)

Query: 153 ARTFDTVKTKDLKSRSPHLDDCSKTDHRAKSDVSKDVHHSTS-LPNLEKEGKPHS----- 206
           +R+    ++K  KSRSP  +      H A    SK    +   + N +  GKP S     
Sbjct: 234 SRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSPSR 293

Query: 207 ------------------DKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGS------SNED 242
                             +KR +     S EK       SRS  + G  S       ++D
Sbjct: 294 HKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSR-SRSRSKGGSRSRSRSRSKSKD 352

Query: 243 SRRGRKDIRHSQFNRGTERVRKDLS--------TGCGDGEPRILEASQRLQGHPEKYGKG 294
            R+GRK  R    +R   R + + S        +  G  + +  E + R Q         
Sbjct: 353 KRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVS 412

Query: 295 EPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNIN 354
           + +  +KS     +S  + +GE  N+   +ET   RS SR +S+S   L  +S RS++ +
Sbjct: 413 KEREHAKS----ESSQREGRGESENAGTNQET---RSRSRSNSKSKPNLPSES-RSRSKS 464

Query: 355 RKEVKSQDKEERKVDQKPKSVVKDQDHWR 383
             + +S+ K   +   +  S  + + H R
Sbjct: 465 ASKTRSRSKSRSRSASRSPSRSRSRSHSR 493



 Score = 32.3 bits (72), Expect = 4.7
 Identities = 33/138 (23%), Positives = 55/138 (39%), Gaps = 10/138 (7%)

Query: 895  AHSTSKSQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKN 954
            +HS  KS+S    + ++ I  +D   +  +   SP     + + RS S+  + +E    +
Sbjct: 259  SHSAGKSRSKSKDQAEEKIQNNDNVGKPKS--RSPSRHKSKSKSRSRSQERRVEEEKRGS 316

Query: 955  SKR--------RVSADVRKSKTIPRRGKSTVCLDKDSRKTHVRIHQTNNKWNKRPDKSSR 1006
              R        R S    +SK   R    +    KD RK   R  + +   ++   KS R
Sbjct: 317  VSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSER 376

Query: 1007 SSKTEKKDKVMSTSSLEK 1024
            S K   K    + SS +K
Sbjct: 377  SRKRGSKRDSKAGSSKKK 394


>gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain
           containing B [Homo sapiens]
          Length = 546

 Score = 62.4 bits (150), Expect = 4e-09
 Identities = 79/351 (22%), Positives = 136/351 (38%), Gaps = 39/351 (11%)

Query: 214 LPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDG 273
           +P  V+K+    + +R           +D + G ++I      R +   R+ LS      
Sbjct: 221 IPVPVQKNIDQQIKTRPR------KIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPR 274

Query: 274 EPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHS 333
             R    S   +GH       E + E +  + +  +    K  R + S ++     RS S
Sbjct: 275 RSR--SRSHHREGHGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRS 332

Query: 334 RVDSQSDKKLERQSERSQNINRK-EVKSQDKEERKVDQKPKSVVKDQDHWRRSER----- 387
           R         ER   RS++ +RK + + +D+E  K +++ +   +D D  R +ER     
Sbjct: 333 R---------ERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERE 383

Query: 388 ASLPHSKNEITFSHNSSKYHLEER--RGWEDCKRD-KSVNSHSFQDGRCPSSLSNSRTHK 444
            S   SK + +      K H E++  R   D KRD K    HS        S S  R H+
Sbjct: 384 RSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHS-------RSRSRERKHR 436

Query: 445 NIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESK--EENRHIRNEKRVPTEHLQKTNK 502
           +              +  K+ +H+ E K K  + S+   + R    EK    EH     K
Sbjct: 437 SRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEK 496

Query: 503 ETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAMKAESGPNETKNKD 553
             K++ +   K+   K D  +  D    +    +  +++ ES   + KNKD
Sbjct: 497 SRKRSRS---KERSHKRDHSDSKDQS-DKHDRRRSQSIEQESQEKQHKNKD 543



 Score = 55.8 bits (133), Expect = 4e-07
 Identities = 57/273 (20%), Positives = 107/273 (39%), Gaps = 17/273 (6%)

Query: 228 SRSHYQVGEGSSNEDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDG--EPRILEASQRLQ 285
           SRSH++ G GSS+ D    R+  R        ER ++   +   D   E R   + +R +
Sbjct: 278 SRSHHREGHGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHR 337

Query: 286 GHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLER 345
                  +   + +    + K N     +G R +  ++KE   ER   R   +S ++ + 
Sbjct: 338 SRSRSRDRKGDRRDRDREREKENE----RGRRRDRDYDKERGNEREKER--ERSRERSKE 391

Query: 346 QSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSK 405
           Q  R +   +K  + +D    + D++     K     R  ER     S++      + S+
Sbjct: 392 QRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSR 451

Query: 406 YHLEERRGWEDCKRDKSVNSHSFQDGRCPS---------SLSNSRTHKNIDSKEVDAMHQ 456
              +  +   + K   +  S S   GR  S         S S  ++ K   SKE      
Sbjct: 452 SKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRD 511

Query: 457 WENTPLKAERHRTEDKRKREQESKEENRHIRNE 489
             ++  ++++H     +  EQES+E+    ++E
Sbjct: 512 HSDSKDQSDKHDRRRSQSIEQESQEKQHKNKDE 544



 Score = 34.7 bits (78), Expect = 0.95
 Identities = 48/232 (20%), Positives = 93/232 (40%), Gaps = 28/232 (12%)

Query: 334 RVDSQSDKKLERQSE-RSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPH 392
           R+     K +++Q + R + I +   +  ++ +R V+++     +     RRS R S   
Sbjct: 220 RIPVPVQKNIDQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRS--R 277

Query: 393 SKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVD 452
           S++     H SS +  E  R  E  + ++       ++ R   S+      +   S+E  
Sbjct: 278 SRSHHREGHGSSSFDRELEREKERQRLEREAKERE-KERRRSRSIDRGLERRRSRSRE-- 334

Query: 453 AMHQWENTPLKAERHRTEDKRKREQESKEENRHIR-----------NEKRVPTEHLQKTN 501
                 +      R R  D+R R++E ++EN   R           NE+    E  ++ +
Sbjct: 335 -----RHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERS 389

Query: 502 KETK-KTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAMKAESGPNETKNK 552
           KE + +   + KK  E K D+    D       D+K+    + S   E K++
Sbjct: 390 KEQRSRGEVEEKKHKEDKDDRRHRDDK-----RDSKKEKKHSRSRSRERKHR 436



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 60/335 (17%), Positives = 124/335 (37%), Gaps = 32/335 (9%)

Query: 23  KNNDEGSLDIYAGLDSAVSDSASKSCVPSRNCLDLYEEILTEEGTAKEATYNDLQVEYGK 82
           K+  EG+ +I   ++   S S  +S  P R+           EG    +   +L+ E  +
Sbjct: 242 KDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKER 301

Query: 83  CQLQMKELMKKFKEIQTQNFSLINENQSLKKNISALIKTARVEINRKDEEISNLHQRLSE 142
            +L+     ++ KE + +     + ++ L++  S   +  R     +D +     +    
Sbjct: 302 QRLE-----REAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDRER 356

Query: 143 FPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHRAKSDVSKDVHHSTSLPNLEKEG 202
                   +  R +D  +  + +       + SK + R++ +V +  H        +K+ 
Sbjct: 357 EKENERGRRRDRDYDKERGNEREKERERSRERSK-EQRSRGEVEEKKHKE------DKDD 409

Query: 203 KPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRGTERV 262
           + H D +  S       +  +     RS  +         SR   K  +H   N   E+ 
Sbjct: 410 RRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHK--NESKEKS 467

Query: 263 RKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSW 322
            K   +G   G    +E S++ +  P K    +     + S  + +SDS  + ++     
Sbjct: 468 NKRSRSG-SQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDK----- 521

Query: 323 EKETPGERSHSRVDSQSDKKLERQSERSQNINRKE 357
                    H R  SQS   +E++S+  Q+ N+ E
Sbjct: 522 ---------HDRRRSQS---IEQESQEKQHKNKDE 544


>gi|42560244 peptidylprolyl isomerase G [Homo sapiens]
          Length = 754

 Score = 62.0 bits (149), Expect = 6e-09
 Identities = 92/397 (23%), Positives = 161/397 (40%), Gaps = 66/397 (16%)

Query: 112 KKNISALIKTARVEINRKDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHL 171
           K  ++ + +  R  +  K+ +I++ H+ +SE P+ +N  +        K KD KS S   
Sbjct: 385 KSELNEIKENQRSPVRVKERKITD-HRNVSESPNRKNEKEK-------KVKDHKSNSKER 436

Query: 172 D--DCSKTDHRAKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSR 229
           D    S+ D + K+ V K    + S    + + K  S +R + H   + EK   +    R
Sbjct: 437 DIRRNSEKDDKYKNKVKK---RAKSKSRSKSKEKSKSKERDSKH-NRNEEKRMRSRSKGR 492

Query: 230 SHYQVGEGSSNEDSR-----RGRKDIRHSQFN----------------RGTERVRK-DLS 267
            H  V E     DS+     R R   +  Q                  R   R R+ D++
Sbjct: 493 DHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSRECDIT 552

Query: 268 TGCGDGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETP 327
            G      R  E S+          +   +  S+S ++    + +Y+    + S E+ TP
Sbjct: 553 KGKHSYNSRTRERSRSRDRSRRVRSRTHDRDRSRSKEYHRYREQEYRRRGRSRSRERRTP 612

Query: 328 GERSHSRVDSQSDKKLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSER 387
             RS S+ D +  ++  R SER ++ +R + K +++E +   +K  S          SE+
Sbjct: 613 PGRSRSK-DRRRRRRDSRSSEREESQSRNKDKYRNQESKSSHRKENS---------ESEK 662

Query: 388 ASLPHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNS---HSFQDGRCPSSLSNSRTHK 444
                S++     HNSS    E++       RD+S  S    S QD    SS+      K
Sbjct: 663 RMYSKSRD-----HNSSNNSREKK-----ADRDQSPFSKIKQSSQDNELKSSML-----K 707

Query: 445 NIDSKEVDAMHQWENTPLKAER--HRTEDKRKREQES 479
           N + +++ +  + EN   K +   H  E  +K + ES
Sbjct: 708 NKEDEKIRSSVEKENQKSKGQENDHVHEKNKKFDHES 744



 Score = 60.8 bits (146), Expect = 1e-08
 Identities = 76/315 (24%), Positives = 136/315 (43%), Gaps = 31/315 (9%)

Query: 276 RILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRV 335
           R +  S   +   EK  K + K+ SK    + NS+ D K +  N   ++     RS S+ 
Sbjct: 410 RNVSESPNRKNEKEKKVK-DHKSNSKERDIRRNSEKDDKYK--NKVKKRAKSKSRSKSKE 466

Query: 336 DSQSDKKLERQSERSQNINRKEVKSQDKEERKVDQKPK-SVVKDQDHWRRSERASLPHSK 394
            S+S ++  + +   +   R   K +D E  K  +K   S  KDQ+  R  E++    SK
Sbjct: 467 KSKSKERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESK 526

Query: 395 NEITFSHNSSKYHLEERRGWEDCKR-DKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDA 453
           +     H+ SK   ++RR     +  D +   HS+          NSRT +   S+  D 
Sbjct: 527 SN---EHDHSKSKEKDRRAQSRSRECDITKGKHSY----------NSRTRER--SRSRDR 571

Query: 454 MHQWENTPLKAERHRTED-KRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLK 512
             +  +     +R R+++  R REQE +   R    E+R P    +  ++  ++  +   
Sbjct: 572 SRRVRSRTHDRDRSRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSS 631

Query: 513 KQNEPKTDKGEVLDNGVSEGADNKELA-----MKAESGPNETKNKDLKLSFMKKLNLTLS 567
           ++ E ++   +   N  S+ +  KE +     M ++S  + + N     S  KK +   S
Sbjct: 632 EREESQSRNKDKYRNQESKSSHRKENSESEKRMYSKSRDHNSSNN----SREKKADRDQS 687

Query: 568 P-AKKQPVSQDNQHK 581
           P +K +  SQDN+ K
Sbjct: 688 PFSKIKQSSQDNELK 702



 Score = 48.5 bits (114), Expect = 6e-05
 Identities = 79/384 (20%), Positives = 160/384 (41%), Gaps = 43/384 (11%)

Query: 199 EKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRG 258
           ++E K H  K S+S   +S +   ++   S S     E ++ E S++ +K  R +     
Sbjct: 185 KEEKKRH--KSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHRKNSRKHK 242

Query: 259 TERVRKDLS--TGCGDGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGE 316
            E+ ++  S  +   + E   LEA  +    PE+     P  E++    KS   +D K E
Sbjct: 243 KEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEI---PPIPENRFLMRKSPPKADEK-E 298

Query: 317 RINSSWEKET--------PGERSHSRVDSQSDKKLE-------RQSERSQN---INRKEV 358
           R N   E+E         P       + ++S +K++       R   RS++     R E 
Sbjct: 299 RKNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTPSRSRSRDRFRRSET 358

Query: 359 KSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCK 418
               ++E +  Q+ +  V   + W + +++ L    NEI   +  S   ++ER+  +   
Sbjct: 359 PPHWRQEMQRAQRMR--VSSGERWIKGDKSEL----NEIK-ENQRSPVRVKERKITDHRN 411

Query: 419 RDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQE 478
             +S N  + ++ +     SNS+      + E D  ++ +       + R++ K K + +
Sbjct: 412 VSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSK 471

Query: 479 SKEENRHIRNEKRVPT-----EHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSE-- 531
            ++   +   EKR+ +     +H     KE +  +    ++     +K + L++  +E  
Sbjct: 472 ERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHD 531

Query: 532 GADNKELAMKAESGPNE---TKNK 552
            + +KE   +A+S   E   TK K
Sbjct: 532 HSKSKEKDRRAQSRSRECDITKGK 555



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 63/296 (21%), Positives = 121/296 (40%), Gaps = 38/296 (12%)

Query: 274 EPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHS 333
           E RIL   + +   P+   K E K   KSS   S+S SD            ++  +   S
Sbjct: 168 EVRILSCGELI---PKSKVKKEEKKRHKSSSSSSSSSSD-----------SDSSSDSQSS 213

Query: 334 RVDSQSDKKLERQSERSQNINRKEVKSQDKEERKVDQKPKSV----------VKDQDHWR 383
              S S+   E +S++ +  +RK  +   KE++K  +  KS            + Q   R
Sbjct: 214 SDSSDSESATEEKSKKRKKKHRKNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVR 273

Query: 384 RSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTH 443
             E   +P  +N      +  K   +ER+  E  +R++  N  + Q       L  +R+ 
Sbjct: 274 PEEIPPIP--ENRFLMRKSPPKADEKERKNRER-ERERECNPPNSQPASYQRRLLVTRSG 330

Query: 444 KNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNKE 503
           + I  +      +   TP    R R+ D+ +R +      + ++  +R+     ++  K 
Sbjct: 331 RKIKGRG----PRRYRTP---SRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKG 383

Query: 504 TKKTTTDLKK-QNEP-KTDKGEVLDN-GVSEGADNK-ELAMKAESGPNETKNKDLK 555
            K    ++K+ Q  P +  + ++ D+  VSE  + K E   K +   + +K +D++
Sbjct: 384 DKSELNEIKENQRSPVRVKERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIR 439



 Score = 40.4 bits (93), Expect = 0.017
 Identities = 76/393 (19%), Positives = 148/393 (37%), Gaps = 37/393 (9%)

Query: 907  KENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKNSK-RRVSADVRK 965
            K+ +K  +KS   + + +  +    + +     SDSE++  ++S ++  K R+ S   +K
Sbjct: 184  KKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHRKNSRKHKK 243

Query: 966  SKTIPRRGKSTVCLDKDSRKTHVRIHQTNNKWNKRPDKSSR-------SSKTEKKDKVMS 1018
             K   ++ K +   + ++     +   T       P   +R           EK+ K   
Sbjct: 244  EKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPENRFLMRKSPPKADEKERKNRE 303

Query: 1019 TSSLEKIVPIIAVPSSEQEIMHMLRMIRKHVRKNYMKFKAKFSLIQFHRIIESAI-LSFT 1077
                 +  P  + P+S Q  + + R  RK   +   +++         R   S     + 
Sbjct: 304  RERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTPSRSRSRDRFRRSETPPHWR 363

Query: 1078 SLIKHLNLHKISKSVTTLQKNLCDIIESKLKQ-----VKKNGIVDRLFEQQLPDMKKKLW 1132
              ++     ++S     ++ +  ++ E K  Q     VK+  I D     + P+ K +  
Sbjct: 364  QEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERKITDHRNVSESPNRKNE-- 421

Query: 1133 KFVDDQLDYLFAKLKKILVCDSKSFGRDSDEGKLEKTSKQNAQYSNSQKRSVDNSNRELL 1192
                        K KK+     K    +S E  + + S+++ +Y N  K+   + +R   
Sbjct: 422  ------------KEKKV-----KDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKS 464

Query: 1193 KEK-LSKSEDPVHYKSLVGCKKSEENYQDQNNSSINTVKHDIK-KNFNICFDNIKNSQSE 1250
            KEK  SK  D  H ++     +S    +D  N      + D K K+        K+ Q E
Sbjct: 465  KEKSKSKERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLE 524

Query: 1251 ERSLE-VHCPSTPKSEKNEGSSIE-DAQTSQHA 1281
             +S E  H  S  K  + +  S E D    +H+
Sbjct: 525  SKSNEHDHSKSKEKDRRAQSRSRECDITKGKHS 557



 Score = 37.4 bits (85), Expect = 0.15
 Identities = 33/161 (20%), Positives = 61/161 (37%), Gaps = 19/161 (11%)

Query: 1739 DLTQDASSEAKSEGNHPALAVEDLGCGVIQVDEDNCKEEKAQVANRPLKCIVEETYIDLT 1798
            ++ ++  ++     + P   V  L CG +       KEEK +  +               
Sbjct: 149  EVVREIENQKTDAASKPFAEVRILSCGELIPKSKVKKEEKKRHKS--------------- 193

Query: 1799 TESPSSCEVKKDELKSEPGSNCDNSELPGTLHNSHKKRRNISDLNHPHKKQRKETDLTNK 1858
              S SS      +  S+  S+ D+S+         KKR+     N   +K +KE     K
Sbjct: 194  -SSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHRKNS--RKHKKEKKKRKK 250

Query: 1859 EKTKKPTQDSCENTEAH-QKKASKKKAPPVTKDPSSLKATP 1898
             K    ++   EN EA  Q     ++ PP+ ++   ++ +P
Sbjct: 251  SKKSASSESEAENLEAQPQSTVRPEEIPPIPENRFLMRKSP 291


>gi|87299628 biorientation of chromosomes in cell division 1-like
            [Homo sapiens]
          Length = 3051

 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 222/1119 (19%), Positives = 401/1119 (35%), Gaps = 180/1119 (16%)

Query: 77   QVEYGKCQLQMKELMKKFKEIQT--QNFSLINENQSLKKNISALIKTARVEINRKDEEIS 134
            Q+   K + + K+  +K K  +T  Q  S ++  +S  K++    K AR++   K+ ++ 
Sbjct: 509  QINREKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEP--KAARIKEVLKERKVL 566

Query: 135  NLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHRAKSDVSKDVHHSTS 194
                 LS     +   K +R  +    K  +      +    ++H  K  +S     S  
Sbjct: 567  EKKVALS-----KKRKKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISS----SKE 617

Query: 195  LPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQ------VGEGSSNE-DSRRGR 247
            L ++  + +P    R  S     V+++       R H +      + EG   E D+R  +
Sbjct: 618  LKHVHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRRTSTPVIMEGVQEETDTRDVK 677

Query: 248  KDIRHSQFNRGTERVRKDLSTGCGDGEPRILEAS----QRLQGHPEKYGKGEPKTESKSS 303
            + +  S+    TE  +K  ST   +   +  ++     + L     K  K +P+ E   S
Sbjct: 678  RQVERSEIC--TEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPEREKTPS 735

Query: 304  KFKSNSDSDYKGERINSSWEK----------------ETPGERSHSRVDSQSDKKLERQS 347
            + K +    YKG+ ++ + ++                +   +++    D ++++K + ++
Sbjct: 736  EDKLSVKHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQQTKLSSDDKTERKSKHRN 795

Query: 348  ERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYH 407
            ER  ++  K+ K   +   K D+  +     +++ ++  R S   +K E     +S    
Sbjct: 796  ERKLSVLGKDGKPVSEYIIKTDENVR-----KENNKKERRLSAEKTKAEHKSRRSSDSKI 850

Query: 408  LEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERH 467
             ++  G +         S S+ + +C   + ++    N+  +EV    +     L  E+ 
Sbjct: 851  QKDSLGSKQHGITLQRRSESYSEDKC--DMDSTNMDSNLKPEEVVHKEKRRTKSLLEEKL 908

Query: 468  RTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDN 527
              + K K + +  +       E         K +KE      D +KQ + K +     + 
Sbjct: 909  VLKSKSKTQGKQVKVVETELQEGATKQATTPKPDKEKNTEENDSEKQRKSKVEDKPFEET 968

Query: 528  GVSEGADNKELAMKAESGPNETKNKDLKLSFMKKLNLTLSPAK--KQPVSQDNQHKITDI 585
            GV       E  ++  S    +  KD   S   KL L     K  K   S   + K++D 
Sbjct: 969  GV-------EPVLETASSSAHSTQKD--SSHRAKLPLAKEKYKSDKDSTSTRLERKLSDG 1019

Query: 586  PKSSGVCDSESSMQVKTVAYVPSISEHILGEAAVSEHTMGETKSTLLEPKVALLAVTEPR 645
             KS  +  S   ++ K      + S+   G+   S H      S+L+E K++       R
Sbjct: 1020 HKSRSLKHSSKDIKKKD----ENKSDDKDGKEVDSSHEKARGNSSLMEKKLSRRLCENRR 1075

Query: 646  IGISETNKEDENSLLVR--SVDNTMHCEEP-ICGTETSFP--SPMEIQQ---TESLF--- 694
              +S+   + E  L     S  +    + P   G  T  P   PMEI      E++F   
Sbjct: 1076 GSLSQEMAKGEEKLAANTLSTPSGSSLQRPKKSGDMTLIPEQEPMEIDSEPGVENVFEVS 1135

Query: 695  --------------PSTGMKQTIN-------------NGRAAAPVVMDVLQTDVSQNFGL 727
                           S  MKQ  +             + +A AP       T V+ N   
Sbjct: 1136 KTQDNRNNNSQQDIDSENMKQKTSATVQKDELRTCTADSKATAPAYKPGRGTGVNSNSEK 1195

Query: 728  ELD------TKRNDNSDYCGISEGMEMKVALSTTV----SETTESILQPSIEEADILPIM 777
              D       K +  S    ++ G +  +   TT     SET   +L  +  E D +   
Sbjct: 1196 HADHRSTLTKKMHIQSAVSKMNPGEKEPIHRGTTEVNIDSETVHRMLLSAPSENDRVQKN 1255

Query: 778  LSE--------------------DNNPKFEPSVIVTPLVESKSCHLEPCLPKET-LDSSL 816
            L                      D++P    SV V PL ES    + P   K T L+ S 
Sbjct: 1256 LKNTAAEEHVAQGDATLEHSTNLDSSPSLS-SVTVVPLRESYDPDVIPLFDKRTVLEGST 1314

Query: 817  QQTELMDHRMATGETNSVYHDD---------------DNSVLSIDLNHLRPIPEA--ISP 859
              T   DH     ++ +V   +                ++     +   R IPEA   + 
Sbjct: 1315 ASTSPADHSALPNQSLTVRESEVLKTSDSKEGGEGFTVDTPAKASITSKRHIPEAHQATL 1374

Query: 860  LNSPVRPVAKVLRNESPPQVPVYNNSHKDVFLPNSAHSTSKSQSDLNKE-NQKPIYKSDK 918
            L+     V   L ++    +    N  K+  L + A    K ++DLN E N K   K+  
Sbjct: 1375 LDGKQGKVIMPLGSKLTGVIVENENITKEGGLVDMA----KKENDLNAEPNLKQTIKA-- 1428

Query: 919  CTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKNSKRRVSADVRKSKTIPRRGKSTVC 978
              E        +D +        +ET K +        + +S DV +     R   S V 
Sbjct: 1429 TVENGKKDGIAVDHVVGLNTEKYAETVKLKHKRSPGKVKDISIDVER-----RNENSEVD 1483

Query: 979  LDKDSRKTHVRIHQTNNKWN------KRPDKSSRSSKTEKKDKVM----------STSSL 1022
                S      +HQ N +        +R +K+S ++ TE KDK +          +T+S 
Sbjct: 1484 TSAGSGSAPSVLHQRNGQTEDVATGPRRAEKTSVATSTEGKDKDVTLSPVKAGPATTTSS 1543

Query: 1023 EKIVPIIAVPSSEQEIMHMLRMIRKHVRKNYMKFKAKFS 1061
            E     +A+P +  E    L +I  H R N +   A+ S
Sbjct: 1544 ETRQSEVALPCTSIEADEGL-IIGTHSRNNPLHVGAEAS 1581



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 91/457 (19%), Positives = 175/457 (38%), Gaps = 72/457 (15%)

Query: 105 INENQSLKKNISALIKTARVEINRKDEEISNLHQRLSE-FPHFRNNHKTARTFDTVKTKD 163
           + +  S +KN S      + + N K E      ++  + F H + +  T +  D  + K+
Sbjct: 307 VQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKE 366

Query: 164 -----LKSRSPHLDDCSKTDHRAKSDVS---KDVH----------HSTSLPNLEKEGKPH 205
                LK  S    + +KT    K D S    DV           H++ L + E++ +  
Sbjct: 367 KEVESLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEE 426

Query: 206 ---SDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRRGR-KDIRHSQFNRG--- 258
              SD      + +  E+          + Q    +   DS  G+ K +RH+  ++    
Sbjct: 427 VVTSDSMEEGEITSDDEE---------KNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLY 477

Query: 259 ------------TERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFK 306
                        E+ R+ ++    + E R+L      +   EK  +   KT+S  +K +
Sbjct: 478 SKYYSDSDDELTVEQRRQSIAK---EKEERLLRRQINREKLEEKRKQKAEKTKSSKTKGQ 534

Query: 307 SNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKSQDKEER 366
             S  D + E    S E +    +   +     +KK+    +R ++   + V+   K+++
Sbjct: 535 GRSSVDLE-ESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKKD--SRNVEENSKKKQ 591

Query: 367 KVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSH 426
           + ++  K  +K  +H  + + +S      E+   H  S+     RR         S + H
Sbjct: 592 QYEEDSKETLKTSEHCEKEKISS----SKELKHVHAKSEPSKPARR--------LSESLH 639

Query: 427 SFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESKEENRHI 486
              + +  S L   R HK   S  V      E T  +  + + E      +E +++   +
Sbjct: 640 VVDENKNESKLE--REHKRRTSTPVIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTL 697

Query: 487 RNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGE 523
           +NEK     HL+K + ET    + LKK+ +   +K E
Sbjct: 698 KNEK-----HLKKDDSETPHLKSLLKKEVKSSKEKPE 729



 Score = 48.1 bits (113), Expect = 8e-05
 Identities = 75/387 (19%), Positives = 139/387 (35%), Gaps = 47/387 (12%)

Query: 235 GEGSSNEDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKG 294
           GE   + + +  RK  +  +  +  +  +K   T     E +  E        P +    
Sbjct: 322 GEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEVESLKLPSEKNSN 381

Query: 295 EPKTESKSSKFKSNSDSDYKG----------ERINSSWEKETPGERSHSRVDSQSDKKLE 344
           + KT   + +  S  DSD  G              SS+E++T  E   S  DS  + ++ 
Sbjct: 382 KAKTVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTS--DSMEEGEIT 439

Query: 345 RQSERSQNINRKEVKSQDKEERKVDQKPKSVV------------KDQDHWRRSERASLPH 392
              E     N+ + ++ D  E K      + V             D +      R S+  
Sbjct: 440 SDDEEKNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAK 499

Query: 393 SKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVD 452
            K E       ++  LEE+R     K +K+ +S +   GR    L  S T K+++ K   
Sbjct: 500 EKEERLLRRQINREKLEEKRKQ---KAEKTKSSKTKGQGRSSVDLEESST-KSLEPKAAR 555

Query: 453 AMHQWENTPLKAERHRTEDKRKREQESKEENRHIR-------NEKRVPTEHLQKTNKETK 505
                +   +  ++     KRK++  + EEN   +        E    +EH +K    + 
Sbjct: 556 IKEVLKERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSS 615

Query: 506 KTTTDLKKQNEPK------TDKGEVLDNGVSEGADNKELAMKA------ESGPNETKNKD 553
           K    +  ++EP       ++   V+D   +E    +E   +       E    ET  +D
Sbjct: 616 KELKHVHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRRTSTPVIMEGVQEETDTRD 675

Query: 554 LKLSFMKKLNLTLSPAKKQPVSQDNQH 580
           +K    +    T  P K++   ++ +H
Sbjct: 676 VKRQVERSEICTEEPQKQKSTLKNEKH 702



 Score = 39.3 bits (90), Expect = 0.039
 Identities = 79/429 (18%), Positives = 153/429 (35%), Gaps = 68/429 (15%)

Query: 61   ILTEEGTAKEATYNDLQVEYGKCQLQMKELMKKFKEIQTQNFSLINENQSLKKNISAL-- 118
            I T+E   KE    + ++   K + + K       +IQ  +        +L++   +   
Sbjct: 814  IKTDENVRKENNKKERRLSAEKTKAEHKSRRSSDSKIQKDSLGSKQHGITLQRRSESYSE 873

Query: 119  ----IKTARVEINRKDEEISNLHQR-----LSEFPHFRNNHKT-ARTFDTVKTK-----D 163
                + +  ++ N K EE+ +  +R     L E    ++  KT  +    V+T+      
Sbjct: 874  DKCDMDSTNMDSNLKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVVETELQEGAT 933

Query: 164  LKSRSPHLDDCSKTDH-----RAKSDVSKDVHHSTSL-PNLEK-EGKPHSDKRSTSH--- 213
             ++ +P  D    T+      + KS V       T + P LE      HS ++ +SH   
Sbjct: 934  KQATTPKPDKEKNTEENDSEKQRKSKVEDKPFEETGVEPVLETASSSAHSTQKDSSHRAK 993

Query: 214  LPTSVEKHCTN--GVWSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRGTERVRKDLSTGCG 271
            LP + EK+ ++     +R   ++ +G  +   +   KDI+    N+  ++  K++ +   
Sbjct: 994  LPLAKEKYKSDKDSTSTRLERKLSDGHKSRSLKHSSKDIKKKDENKSDDKDGKEVDSS-- 1051

Query: 272  DGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSN-----SDSDYKGERINSSWEKET 326
                           H +  G      +  S +   N     S    KGE   ++    T
Sbjct: 1052 ---------------HEKARGNSSLMEKKLSRRLCENRRGSLSQEMAKGEEKLAANTLST 1096

Query: 327  PGERSHSRVDSQSDKKLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSE 386
            P   S  R     D  L  + E  +  +   V++  +  +  D +  +  +D D     +
Sbjct: 1097 PSGSSLQRPKKSGDMTLIPEQEPMEIDSEPGVENVFEVSKTQDNRNNNSQQDIDSENMKQ 1156

Query: 387  RASLPHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNI 446
            + S    K+E+                   C  D    + +++ GR     SNS  H + 
Sbjct: 1157 KTSATVQKDEL-----------------RTCTADSKATAPAYKPGRGTGVNSNSEKHADH 1199

Query: 447  DSKEVDAMH 455
             S     MH
Sbjct: 1200 RSTLTKKMH 1208



 Score = 31.6 bits (70), Expect = 8.1
 Identities = 52/248 (20%), Positives = 97/248 (39%), Gaps = 20/248 (8%)

Query: 278  LEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDS 337
            +E +QR     E +   E  +       K++S+++    R+    ++ +  E +  + + 
Sbjct: 2795 IETAQRQCPETEPHDTKEENSRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTGEKPEQ 2854

Query: 338  QSDKKLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQ---DHWRRSERASLPHSK 394
              D  ++ Q E    I    +K +    RK   +    +KD    D    +   S   SK
Sbjct: 2855 NDDDTIKSQEEDQPII----IKRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSPSSSK 2910

Query: 395  NEITFSHNSSKY--HLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVD 452
             ++  +  S+K   +L+ER    D   +K V S   +  +   SL+ S    + +S E +
Sbjct: 2911 LKVMQTDESNKETANLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVS---DDAESSEPE 2967

Query: 453  AMHQWENTPLKAERHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLK 512
               Q      K+     EDK+  EQES EE      ++         T  E +++ T L 
Sbjct: 2968 RKRQ------KSVSDPVEDKK--EQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQLS 3019

Query: 513  KQNEPKTD 520
               + K +
Sbjct: 3020 PSIKRKRE 3027


>gi|82830424 gon-4-like isoform a [Homo sapiens]
          Length = 2240

 Score = 61.6 bits (148), Expect = 7e-09
 Identities = 47/145 (32%), Positives = 75/145 (51%), Gaps = 8/145 (5%)

Query: 1836 RRNISDLNHPHKKQRKETDLTNKEKTKKPTQDSCENTEAHQKKASKKKAPP--VTKDPSS 1893
            RR++S    P  ++R       + KT+  T    E+        +  KAP   + KD  +
Sbjct: 2063 RRHVS--GKPDTQERWLPSSRARVKTRDRTCPVHESPSGIDTSETSPKAPRGGLAKDSGT 2120

Query: 1894 -LKATPGIKDSSAALATSTSLSAKNVIKKKGEIIILWTRNDDREILLECQKRGPSFKTFA 1952
              K   G +   AA AT  + ++K  +   GE ++LWTR  DR IL  CQ++G   +TF 
Sbjct: 2121 QAKGPEGEQQPKAAEATVCANNSK--VSSTGEKVVLWTREADRVILTMCQEQGAQPQTFN 2178

Query: 1953 YLAAKL-DKNPNQVSERFQQLMKLF 1976
             ++ +L +K P +VS RF++LM+LF
Sbjct: 2179 IISQQLGNKTPAEVSHRFRELMQLF 2203


>gi|109255228 centrosomal protein 170kDa isoform alpha [Homo sapiens]
          Length = 1584

 Score = 60.8 bits (146), Expect = 1e-08
 Identities = 184/920 (20%), Positives = 349/920 (37%), Gaps = 144/920 (15%)

Query: 175  SKTDHRAKSDVSKDVHHS--TSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHY 232
            +K D   +SD      H   +    LE+  + H  +        + EKH    V S +H+
Sbjct: 371  NKHDDGTQSDSENAGAHRRCSKRATLEEHLRRHHSEHKKLQKVQATEKHQDQAVTSSAHH 430

Query: 233  QVGEGSSNEDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYG 292
            + G G            + H +     ++  ++ S      +  +L +S  L   P +  
Sbjct: 431  RGGHG------------VPHGKL---LKQKSEEPSVSIPFLQTALLRSSGSLGHRPSQEM 475

Query: 293  KGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQN 352
                K ++ S+  + ++D D + ++   + E E P        + ++ K +++      N
Sbjct: 476  DKMLKNQATSATSEKDNDDD-QSDKGTYTIELENPNSE-----EVEARKMIDKVFGVDDN 529

Query: 353  INRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERR 412
                    QD     +++K K ++KD   W  S  A++   +  +T    S  +H EE  
Sbjct: 530  --------QDYNRPVINEKHKDLIKD---WALSSAAAVMEERKPLT---TSGFHHSEEGT 575

Query: 413  GWEDCKRDKS-----VNSHSFQDGR-------CPSSLSNSRTHKNIDSKEVDAMHQWENT 460
                 KR  S       +H+  D          P  L N      I    +        T
Sbjct: 576  SSSGSKRWVSQWASLAANHTRHDQEERIMEFSAPLPLEN---ETEISESGMTVRSTGSAT 632

Query: 461  PLKAE---RHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEP 517
             L ++   R RT  +   E++S E +R     +R      Q T  + K+T T + ++++ 
Sbjct: 633  SLASQGERRRRTLPQLPNEEKSLESHRAKVVTQRSEIGEKQDTELQEKETPTQVYQKDKQ 692

Query: 518  KTDK------GEVLDNGVSEGADNKELAMKAESGPNETKNK-DLKLSFMKKLNLTLSPAK 570
              D+        V    +  G DNK L     S P + K++ D + S +K+   TL+  +
Sbjct: 693  DADRPLSKMNRAVNGETLKTGGDNKTLLHLGSSAPGKEKSETDKETSLVKQ---TLAKLQ 749

Query: 571  KQPVSQDNQHKITDIPKSSGVCDSESSMQVKTVAYVPSISEHILGEAAVSEHTMGETKST 630
            +Q   ++ Q   T +  S  V       + +T        E   G +      + +++S 
Sbjct: 750  QQEQREEAQWTPTKL-SSKNVSGQTDKCREETFKQESQPPEKNSGHSTSKGDRVAQSESK 808

Query: 631  LLEPKVALLAVTEPRIGISETNKEDENSLLVRSVDNTMHCEEPICGTE---------TSF 681
              + +  L + T P+ G    +K++ +  LVR    T+    P    E         +S 
Sbjct: 809  RRKAEEILKSQT-PKGG----DKKESSKSLVRQGSFTIEKPSPNIPIELIPHINKQTSST 863

Query: 682  PSPMEI-------QQTESLFPSTGMKQT--INNGRAAAPVVMDVLQTDVSQNFGLELDTK 732
            PS + +       +++ESL P + M  T  + +  A    +   L+ D   + G +  + 
Sbjct: 864  PSSLALTSASRIRERSESLDPDSSMDTTLILKDTEAVMAFLEAKLREDNKTDEGPDTPSY 923

Query: 733  RNDNSDYCGISEGMEMKVALSTTVSETTESILQPSIEEADILPIMLSEDNNPKFEPSVIV 792
              DNS    IS   E  V  ++T+S  T    + S ++       L +D      PS  V
Sbjct: 924  NRDNS----ISP--ESDVDTASTISLVTGETERKSTQKRKSF-TSLYKDRCSTGSPSKDV 976

Query: 793  TPLVESKSCHLEPCLPKETLDSSLQQTELMDHR---MATG-------------ETNSVYH 836
            T   +S S      + K+T   S       D R    ++G             +T+SV H
Sbjct: 977  T---KSSSSGAREKMEKKTKSRSTDVGSRADGRKFVQSSGRIRQPSVDLTDDDQTSSVPH 1033

Query: 837  DDDNSVLSIDLNHLRPIPEAISPLNSPVRPV------AKVLRNESPPQVPVYNNSHKDVF 890
               + ++S D       P   +PL S    V      +KV ++++ P V   ++    + 
Sbjct: 1034 SAISDIMSSDQETYSCKPHGRTPLTSADEHVHSKLEGSKVTKSKTSPVVSGSSSKSTTLP 1093

Query: 891  LPNSAHSTSKSQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQES 950
             P    ++   ++ L + +   +  +DK + A              E+ + S TSKP   
Sbjct: 1094 RPRPTRTSLLRRARLGEASDSELADADKASVA-------------SEVSTTSSTSKPPTG 1140

Query: 951  FEKNSKRRVSADVRKSK--TIPRRGKS--TVCLDKDSRKTHVRIHQT------NNKWNKR 1000
                S+  + A  R+++  ++  R  S  T+     S +T   I ++      ++K++ R
Sbjct: 1141 RRNISRIDLLAQPRRTRLGSLSARSDSEATISRSSASSRTAEAIIRSGARLVPSDKFSPR 1200

Query: 1001 PDKSSRSSKTEKKDKVMSTS 1020
               +S S  ++ K K M+++
Sbjct: 1201 IRANSISRLSDSKVKSMTSA 1220


>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
           sapiens]
          Length = 600

 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 54/256 (21%), Positives = 111/256 (43%), Gaps = 20/256 (7%)

Query: 299 ESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEV 358
           ES   +    +  D  G+    + +KE    R   + + ++D+K ER+ E+ ++  RK  
Sbjct: 35  ESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRH--RKRD 92

Query: 359 KSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCK 418
           + ++++  +  ++ +   +++D  R  ER      + E             ER G  +  
Sbjct: 93  RHRERQRDREKERERQTDRERDRQREKERNRQKERERET------------EREG--ERG 138

Query: 419 RDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQE 478
           RD+  +    ++ +  +     R       ++ +   Q E    K  + R E +R+RE+E
Sbjct: 139 RDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKE 198

Query: 479 SKEENRHIRNEKRVPTEHLQKTNKET-KKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKE 537
           +K E+RH  +E+    E  ++T  ET +K  TD ++  + KT++ E       E A  +E
Sbjct: 199 NKTEDRH--SERGRERERERETETETERKRQTDRERDRQRKTER-EREKQAERERASERE 255

Query: 538 LAMKAESGPNETKNKD 553
                E      +++D
Sbjct: 256 TERDKERERERDRDRD 271



 Score = 51.6 bits (122), Expect = 8e-06
 Identities = 69/365 (18%), Positives = 126/365 (34%), Gaps = 38/365 (10%)

Query: 163 DLKSRSPHLDDCSKTDHRAKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHC 222
           D   R P   +  +   R      KD        N +KE +   +KR T        +  
Sbjct: 25  DFSRRRPGSQESPR--RRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERR 82

Query: 223 TNGVWSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQ 282
                 R   +  E   + +  R R+  R     R  ER R+       + E       +
Sbjct: 83  REKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGE-RGRDR 141

Query: 283 RLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKK 342
           +  G  E+  + + + E +    +       +  +     EK     R   R   + +K 
Sbjct: 142 QTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKT 201

Query: 343 LERQSERSQNINR-KEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSH 401
            +R SER +   R +E +++ + +R+ D       +++D  R++ER     ++ E     
Sbjct: 202 EDRHSERGRERERERETETETERKRQTD-------RERDRQRKTEREREKQAERERASER 254

Query: 402 NSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTP 461
            + +    ER    D  RD+       Q  R                             
Sbjct: 255 ETERDKERERERDRDRDRDRRQKERERQTDR--------------------------KRQ 288

Query: 462 LKAERHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDK 521
            + ER R E +RKRE++ + E    RN KR      ++  +  ++T  D +K+ E K  +
Sbjct: 289 RRTERDR-ETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKR 347

Query: 522 GEVLD 526
              +D
Sbjct: 348 QTEMD 352



 Score = 48.1 bits (113), Expect = 8e-05
 Identities = 56/292 (19%), Positives = 113/292 (38%), Gaps = 25/292 (8%)

Query: 243 SRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTES-- 300
           + R R+  R  + NR   R R+         E R  E  +  +   E   + E K ++  
Sbjct: 171 TERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDR 230

Query: 301 -KSSKFKSNSDSDYKGERINSSW-----EKETPGERSHSRVDSQSDKKLERQSERSQNIN 354
            +  + K+  + + + ER  +S      +KE   ER   R   +  K+ ERQ++R     
Sbjct: 231 ERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDR----K 286

Query: 355 RKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGW 414
           R+    +D+E  +  ++ +   ++++  R+ ER      + E        +    ER+  
Sbjct: 287 RQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRK 346

Query: 415 EDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRK 474
              + D+  N  + ++GR  +     R       +E D     E    + +R R   K +
Sbjct: 347 RQTEMDRERNRQTGREGRRQAERERER------ERERDRQSAREREERERDRDRDRQKER 400

Query: 475 REQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLD 526
             Q  K+ +     EK       Q+  ++ +++    ++  E +  KG   D
Sbjct: 401 ERQTEKDRDGQRETEK-------QREREKDRESERGRERGREREKQKGRERD 445


>gi|109255230 centrosomal protein 170kDa isoform beta [Homo sapiens]
          Length = 1486

 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 165/796 (20%), Positives = 305/796 (38%), Gaps = 118/796 (14%)

Query: 301  KSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEV-- 358
            K +K    + SD +    +    K    E  H R      KKL++     ++ ++  V  
Sbjct: 369  KGNKHDDGTQSDSENAGAHRRCSKRATLEE-HLRRHHSEHKKLQKVQATEKHQDQAVVFG 427

Query: 359  --KSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWED 416
               +QD     +++K K ++KD   W  S  A++   +  +T    S  +H EE      
Sbjct: 428  VDDNQDYNRPVINEKHKDLIKD---WALSSAAAVMEERKPLT---TSGFHHSEEGTSSSG 481

Query: 417  CKRDKS-----VNSHSFQDGR-------CPSSLSNSRTHKNIDSKEVDAMHQWENTPLKA 464
             KR  S       +H+  D          P  L N      I    +        T L +
Sbjct: 482  SKRWVSQWASLAANHTRHDQEERIMEFSAPLPLENET---EISESGMTVRSTGSATSLAS 538

Query: 465  E---RHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDK 521
            +   R RT  +   E++S E +R     +R      Q T  + K+T T + ++++   D+
Sbjct: 539  QGERRRRTLPQLPNEEKSLESHRAKVVTQRSEIGEKQDTELQEKETPTQVYQKDKQDADR 598

Query: 522  G------EVLDNGVSEGADNKELAMKAESGPNETKNK-DLKLSFMKKLNLTLSPAKKQPV 574
                    V    +  G DNK L     S P + K++ D + S +K+   TL+  ++Q  
Sbjct: 599  PLSKMNRAVNGETLKTGGDNKTLLHLGSSAPGKEKSETDKETSLVKQ---TLAKLQQQEQ 655

Query: 575  SQDNQHKITDIPKSSGVCDSESSMQVKTVAYVPSISEHILGEAAVSEHTMGETKSTLLEP 634
             ++ Q   T +  S  V       + +T        E   G +      + +++S   + 
Sbjct: 656  REEAQWTPTKL-SSKNVSGQTDKCREETFKQESQPPEKNSGHSTSKGDRVAQSESKRRKA 714

Query: 635  KVALLAVTEPRIGISETNKEDENSLLVRSVDNTMHCEEPICGTE---------TSFPSPM 685
            +  L + T P+ G    +K++ +  LVR    T+    P    E         +S PS +
Sbjct: 715  EEILKSQT-PKGG----DKKESSKSLVRQGSFTIEKPSPNIPIELIPHINKQTSSTPSSL 769

Query: 686  EI-------QQTESLFPSTGMKQT--INNGRAAAPVVMDVLQTDVSQNFGLELDTKRNDN 736
             +       +++ESL P + M  T  + +  A    +   L+ D   + G +  +   DN
Sbjct: 770  ALTSASRIRERSESLDPDSSMDTTLILKDTEAVMAFLEAKLREDNKTDEGPDTPSYNRDN 829

Query: 737  SDYCGISEGMEMKVALSTTVSETTESILQPSIEEADILPIMLSEDNNPKFEPSVIVTPLV 796
            S    IS   E  V  ++T+S  T    + S ++       L +D      PS  VT   
Sbjct: 830  S----ISP--ESDVDTASTISLVTGETERKSTQKRKSF-TSLYKDRCSTGSPSKDVT--- 879

Query: 797  ESKSCHLEPCLPKETLDSSLQQTELMDHR---MATG-------------ETNSVYHDDDN 840
            +S S      + K+T   S       D R    ++G             +T+SV H   +
Sbjct: 880  KSSSSGAREKMEKKTKSRSTDVGSRADGRKFVQSSGRIRQPSVDLTDDDQTSSVPHSAIS 939

Query: 841  SVLSIDLNHLRPIPEAISPLNSPVRPV------AKVLRNESPPQVPVYNNSHKDVFLPNS 894
             ++S D       P   +PL S    V      +KV ++++ P V   ++    +  P  
Sbjct: 940  DIMSSDQETYSCKPHGRTPLTSADEHVHSKLEGSKVTKSKTSPVVSGSSSKSTTLPRPRP 999

Query: 895  AHSTSKSQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKN 954
              ++   ++ L + +   +  +DK + A              E+ + S TSKP       
Sbjct: 1000 TRTSLLRRARLGEASDSELADADKASVA-------------SEVSTTSSTSKPPTGRRNI 1046

Query: 955  SKRRVSADVRKSK--TIPRRGKS--TVCLDKDSRKTHVRIHQT------NNKWNKRPDKS 1004
            S+  + A  R+++  ++  R  S  T+     S +T   I ++      ++K++ R   +
Sbjct: 1047 SRIDLLAQPRRTRLGSLSARSDSEATISRSSASSRTAEAIIRSGARLVPSDKFSPRIRAN 1106

Query: 1005 SRSSKTEKKDKVMSTS 1020
            S S  ++ K K M+++
Sbjct: 1107 SISRLSDSKVKSMTSA 1122


>gi|109255232 centrosomal protein 170kDa isoform gamma [Homo sapiens]
          Length = 1460

 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 165/796 (20%), Positives = 305/796 (38%), Gaps = 118/796 (14%)

Query: 301  KSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEV-- 358
            K +K    + SD +    +    K    E  H R      KKL++     ++ ++  V  
Sbjct: 369  KGNKHDDGTQSDSENAGAHRRCSKRATLEE-HLRRHHSEHKKLQKVQATEKHQDQAVVFG 427

Query: 359  --KSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWED 416
               +QD     +++K K ++KD   W  S  A++   +  +T    S  +H EE      
Sbjct: 428  VDDNQDYNRPVINEKHKDLIKD---WALSSAAAVMEERKPLT---TSGFHHSEEGTSSSG 481

Query: 417  CKRDKS-----VNSHSFQDGR-------CPSSLSNSRTHKNIDSKEVDAMHQWENTPLKA 464
             KR  S       +H+  D          P  L N      I    +        T L +
Sbjct: 482  SKRWVSQWASLAANHTRHDQEERIMEFSAPLPLENET---EISESGMTVRSTGSATSLAS 538

Query: 465  E---RHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDK 521
            +   R RT  +   E++S E +R     +R      Q T  + K+T T + ++++   D+
Sbjct: 539  QGERRRRTLPQLPNEEKSLESHRAKVVTQRSEIGEKQDTELQEKETPTQVYQKDKQDADR 598

Query: 522  G------EVLDNGVSEGADNKELAMKAESGPNETKNK-DLKLSFMKKLNLTLSPAKKQPV 574
                    V    +  G DNK L     S P + K++ D + S +K+   TL+  ++Q  
Sbjct: 599  PLSKMNRAVNGETLKTGGDNKTLLHLGSSAPGKEKSETDKETSLVKQ---TLAKLQQQEQ 655

Query: 575  SQDNQHKITDIPKSSGVCDSESSMQVKTVAYVPSISEHILGEAAVSEHTMGETKSTLLEP 634
             ++ Q   T +  S  V       + +T        E   G +      + +++S   + 
Sbjct: 656  REEAQWTPTKL-SSKNVSGQTDKCREETFKQESQPPEKNSGHSTSKGDRVAQSESKRRKA 714

Query: 635  KVALLAVTEPRIGISETNKEDENSLLVRSVDNTMHCEEPICGTE---------TSFPSPM 685
            +  L + T P+ G    +K++ +  LVR    T+    P    E         +S PS +
Sbjct: 715  EEILKSQT-PKGG----DKKESSKSLVRQGSFTIEKPSPNIPIELIPHINKQTSSTPSSL 769

Query: 686  EI-------QQTESLFPSTGMKQT--INNGRAAAPVVMDVLQTDVSQNFGLELDTKRNDN 736
             +       +++ESL P + M  T  + +  A    +   L+ D   + G +  +   DN
Sbjct: 770  ALTSASRIRERSESLDPDSSMDTTLILKDTEAVMAFLEAKLREDNKTDEGPDTPSYNRDN 829

Query: 737  SDYCGISEGMEMKVALSTTVSETTESILQPSIEEADILPIMLSEDNNPKFEPSVIVTPLV 796
            S    IS   E  V  ++T+S  T    + S ++       L +D      PS  VT   
Sbjct: 830  S----ISP--ESDVDTASTISLVTGETERKSTQKRKSF-TSLYKDRCSTGSPSKDVT--- 879

Query: 797  ESKSCHLEPCLPKETLDSSLQQTELMDHR---MATG-------------ETNSVYHDDDN 840
            +S S      + K+T   S       D R    ++G             +T+SV H   +
Sbjct: 880  KSSSSGAREKMEKKTKSRSTDVGSRADGRKFVQSSGRIRQPSVDLTDDDQTSSVPHSAIS 939

Query: 841  SVLSIDLNHLRPIPEAISPLNSPVRPV------AKVLRNESPPQVPVYNNSHKDVFLPNS 894
             ++S D       P   +PL S    V      +KV ++++ P V   ++    +  P  
Sbjct: 940  DIMSSDQETYSCKPHGRTPLTSADEHVHSKLEGSKVTKSKTSPVVSGSSSKSTTLPRPRP 999

Query: 895  AHSTSKSQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKN 954
              ++   ++ L + +   +  +DK + A              E+ + S TSKP       
Sbjct: 1000 TRTSLLRRARLGEASDSELADADKASVA-------------SEVSTTSSTSKPPTGRRNI 1046

Query: 955  SKRRVSADVRKSK--TIPRRGKS--TVCLDKDSRKTHVRIHQT------NNKWNKRPDKS 1004
            S+  + A  R+++  ++  R  S  T+     S +T   I ++      ++K++ R   +
Sbjct: 1047 SRIDLLAQPRRTRLGSLSARSDSEATISRSSASSRTAEAIIRSGARLVPSDKFSPRIRAN 1106

Query: 1005 SRSSKTEKKDKVMSTS 1020
            S S  ++ K K M+++
Sbjct: 1107 SISRLSDSKVKSMTSA 1122


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 59.7 bits (143), Expect = 3e-08
 Identities = 60/304 (19%), Positives = 128/304 (42%), Gaps = 22/304 (7%)

Query: 261  RVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINS 320
            R R++L       E    E  Q L+  PEK  + E + + +  +     +     E    
Sbjct: 1071 RRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREK 1130

Query: 321  SWEKETPGE-RSHSRVDSQSDKKLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQ 379
               +E   + R    V  + ++ L  + E+ +   R+E++ Q +EE ++ Q+ + +++++
Sbjct: 1131 RRRQELERQYREEEEVQQEEEQLLREEPEKRR---RQELERQYREEEELQQEEEQLLREE 1187

Query: 380  DHWRRSERASLPHSKNEITFSHNSSKYHLEERRG-----WEDCKRDKSVNSHSFQDGRCP 434
               RR ER      + E+       +Y  E++R      WE  K +   ++  +  GR  
Sbjct: 1188 QEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGR-- 1245

Query: 435  SSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESK---EENRHIRNEKR 491
                N +  +  DS+  D   Q +   L  E    + +R REQE +   + +RH   E++
Sbjct: 1246 ---ENEQFRQLEDSQLRDRQSQQDLQHLLGE----QQERDREQERRRWQQRDRHFPEEEQ 1298

Query: 492  VPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAMKAESGPNETKN 551
            +  E  ++  +  +K+  + +   E + +K    +    +  + ++L  + E  P   + 
Sbjct: 1299 LEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETD-RKFREEEQLLQEREEQPLRRQE 1357

Query: 552  KDLK 555
            +D K
Sbjct: 1358 RDRK 1361



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 82/433 (18%), Positives = 162/433 (37%), Gaps = 41/433 (9%)

Query: 95   KEIQTQNFSLINENQSLKKNISALIKTARVEINRKDEEISNLHQRLSEFPHFRNNHKTAR 154
            +E+Q +   L+ E +  K+    L +  R E   + EE     Q L E P  R   +  R
Sbjct: 1114 EELQQEEEQLLREERE-KRRRQELERQYREEEEVQQEE----EQLLREEPEKRRRQELER 1168

Query: 155  TFDTVKTKDLKSRSPHLDDCSKTDHRAKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHL 214
             +   + ++L+     L    +   + + +  +       L   +K  + + D+   S L
Sbjct: 1169 QYR--EEEELQQEEEQL--LREEQEKRRQERERQYREEEELQR-QKRKQRYRDEDQRSDL 1223

Query: 215  PTSVEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGE 274
                E    N V     Y   +G  NE  R+    +  SQ      + ++DL    G+ +
Sbjct: 1224 KWQWEPEKENAVRDNKVYC--KGRENEQFRQ----LEDSQLR--DRQSQQDLQHLLGEQQ 1275

Query: 275  PRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSR 334
             R  E  +R     +++   E + E +  K     D   + E+      +    ER   R
Sbjct: 1276 ERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEK------QLLREEREEKR 1329

Query: 335  VDSQSDKKLERQSERSQNINRKEVKSQDK------EERKVDQKPKSVVKDQDHWRRSERA 388
               ++D+K   + +  Q    + ++ Q++      EE +  ++ +  ++++   RR ER 
Sbjct: 1330 RRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQER- 1388

Query: 389  SLPHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDS 448
                   E  F     +   +ER       RD+       Q  R           + +  
Sbjct: 1389 -------ERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRR 1441

Query: 449  KEVDAMHQWENTPLKAERH---RTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNKETK 505
            +E +     E   L+ ERH   R E++  +E+E ++ +R  R+ K +  E   +  +  +
Sbjct: 1442 QERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDR 1501

Query: 506  KTTTDLKKQNEPK 518
            K      +  EP+
Sbjct: 1502 KFREQELRSQEPE 1514



 Score = 49.3 bits (116), Expect = 4e-05
 Identities = 59/334 (17%), Positives = 137/334 (41%), Gaps = 28/334 (8%)

Query: 244 RRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTESKSS 303
           R+  ++ R  Q  R  ++ R++        E R  +  +  +   E+  + E + E +  
Sbjct: 308 RKQEEERREQQEERREQQERREQQE-----ERREQQLRREQEERREQQLRREQEEERREQ 362

Query: 304 KFKSNSDSDYKGERINSSWEKETPGE-------RSHSRVDSQSDKKLERQSERSQNINRK 356
           + +   + + + +++    +     +       R   ++  +   + E+Q  R Q + R+
Sbjct: 363 QLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 422

Query: 357 EVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWED 416
           +   +++EE + +QK +   ++Q   R  E       + E T  H   +   + +R  E+
Sbjct: 423 QQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEE 482

Query: 417 CKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKRE 476
            +R++ +     ++ R        +  +  + +    + + E      +R R+E + +RE
Sbjct: 483 ERRERWLKLEE-EERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRRE 541

Query: 477 QESKEENRHIR-NEKRVPTEHLQKTNKETKKTTTD--LKKQNEP-----KTDKGEVLDNG 528
           QE + E    R  EKR+  E  ++  K  ++   D  LK++ E      K ++ E L+  
Sbjct: 542 QEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQR 601

Query: 529 VS-------EGADNKELAMKAESGPNETKNKDLK 555
           +        E  + +E  +K E    E + + LK
Sbjct: 602 LKREEVERLEQEERREQRLKREEPEEERRQQLLK 635



 Score = 49.3 bits (116), Expect = 4e-05
 Identities = 83/501 (16%), Positives = 184/501 (36%), Gaps = 58/501 (11%)

Query: 55  LDLYEEILTEEGTAKEATYNDLQVEYGKCQLQMKELMKKFKEIQTQNFSLINENQSLKKN 114
           L L EE   E+   +E      Q E  + +L+ +E  ++ ++       L  E +  ++ 
Sbjct: 489 LKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQ 548

Query: 115 ISALIKTARVEINRKDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPH---- 170
           +    +  R+E  R+++ +    +   +    R   +  +     + + L+ R       
Sbjct: 549 LLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVE 608

Query: 171 -LDDCSKTDHRAKSDVSKDVHHSTSLPNLEKEGKPHSD------KRSTSHLPTSVEKHCT 223
            L+   + + R K +  ++      L + E+E +          +R    L    E+   
Sbjct: 609 RLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERL 668

Query: 224 NGVWSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRGTERVRK-------------DLSTGC 270
                R H         E+ RR  +++   +  +  ER++              D     
Sbjct: 669 EQRLKREH---------EEERR-EQELAEEEQEQARERIKSRIPKWQWQLESEADARQSK 718

Query: 271 GDGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGER-INSSWEKETPGE 329
               PR  E  +R Q   EK  + E + + +  +       + +  R     W+ E   E
Sbjct: 719 VYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSE 778

Query: 330 RSHSRVDS------QSDKKL---ERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQD 380
           R   R+ +      Q +++L   ERQ    + +  +E K Q + +R+  +K    +++++
Sbjct: 779 RGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEE 838

Query: 381 HWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNS 440
             +R ERA     + +            +ERR  ++ +RD+       ++ +        
Sbjct: 839 QLQRRERAQQLQEEED-------GLQEDQERRRSQEQRRDQKWRWQLEEERK-------R 884

Query: 441 RTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKT 500
           R H       +    + E   L+ E    + + + ++  +E+ R  R E+++  E  Q  
Sbjct: 885 RRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLL 944

Query: 501 NKETKKTTTDLKKQNEPKTDK 521
            +E +K     +++   K  K
Sbjct: 945 REEREKRRRQERERQYRKDKK 965



 Score = 46.2 bits (108), Expect = 3e-04
 Identities = 81/482 (16%), Positives = 176/482 (36%), Gaps = 73/482 (15%)

Query: 84   QLQMKELMKKFKEIQTQ------NFSLINENQSLKKNISALIKTARVEINRKDEEISNLH 137
            QL  +E  +KF+E + Q          + E Q L++      +     +  ++E+  +  
Sbjct: 1422 QLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQ 1481

Query: 138  QRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTD--HRAKSDVSKDVHHSTSL 195
            +R  +F       +        + ++L+S+ P      +    HR +    K +     L
Sbjct: 1482 ERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQ-RKFLQEEQQL 1540

Query: 196  PNLEKEGKPHSDK----RSTSHLPTSVEKHCTNGVWSRSHYQVGEGS--SNEDSRRGRKD 249
               E+  +   D+    R    L    E+   +       +++ E      E  R+  +D
Sbjct: 1541 RRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMED 1600

Query: 250  IRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRL---QGHPEKYGKGEPKTESKSSKFK 306
             +  +   G +++R++      + E  + E  ++    Q    K+ + EP+   +  + +
Sbjct: 1601 EQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQ 1660

Query: 307  SNSDSDYK---GERINSSWEKETPGERSHSRVDSQSDKKLERQS------ERSQNINRKE 357
               D D K    E++    E++    +   R   + +++L RQ       +  Q + R+E
Sbjct: 1661 LRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQE 1720

Query: 358  VKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEER----RG 413
            ++ + +EE ++ Q+      +Q+  RR ER      + ++       +   +ER    R 
Sbjct: 1721 LERKFREEEQLRQET-----EQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFRE 1775

Query: 414  WEDCKRDKSVNSHSFQDG----RCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRT 469
             E  ++++       Q+     R    L   R  + +  ++ D  ++WE   L+ E    
Sbjct: 1776 EEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQ 1835

Query: 470  ---------------------------------EDKRKREQESKEENRHIRNEKRVPTEH 496
                                             E KR++E+E K    HIR +++    H
Sbjct: 1836 RLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRH 1895

Query: 497  LQ 498
             Q
Sbjct: 1896 RQ 1897



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 54/268 (20%), Positives = 111/268 (41%), Gaps = 15/268 (5%)

Query: 245  RGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRL-QGHPEKYGKGEPKT--ESK 301
            +GRK +   Q  R  ER RK L     + + R  E  Q+L Q    K+ + E +   + +
Sbjct: 1372 QGRKFLEEEQRLRRQERERKFLKE---EQQLRCQEREQQLRQDRDRKFREEEQQLSRQER 1428

Query: 302  SSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKSQ 361
              KF+       + ER     E+E    +   R   + ++ L+ + E+  +   ++ K  
Sbjct: 1429 DRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFL 1488

Query: 362  DKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEER--RGWEDCKR 419
            ++E++   Q+     ++Q+   +         + ++       K+  EE+  R  E  ++
Sbjct: 1489 EEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQ 1548

Query: 420  DKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLK---AERHRTEDKRK-R 475
             +      F++      L   R  + +  +E D   + E   ++    ER   ED+++ R
Sbjct: 1549 RRQDRDRKFRE---EEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLR 1605

Query: 476  EQESKEENRHIRNEKRVPTEHLQKTNKE 503
             QE +++ R  R+ K    E L +  +E
Sbjct: 1606 RQEGQQQLRQERDRKFREDEQLLQEREE 1633



 Score = 41.6 bits (96), Expect = 0.008
 Identities = 65/357 (18%), Positives = 135/357 (37%), Gaps = 37/357 (10%)

Query: 245  RGRKDIRHSQFNRGTERVRKDLSTGCGDGEP--RILEASQRL--QGHPEKYGKGEPKTES 300
            R RK +   Q  R  ER RK         EP  + LE  Q+L  Q    K+ + E +   
Sbjct: 1483 RDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRR 1542

Query: 301  KSSKFKSNSDSDYK---GERINSSWEKETPGERSHSRVDSQSDKKLERQS-ERSQNINRK 356
            +    +   D D K    E++    E++    +   R     ++K+ RQ  ER    + +
Sbjct: 1543 QERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQ 1602

Query: 357  EVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWED 416
            +++ Q+ +++   ++ +   +D+   +  E   L   + +  F     +   +ER     
Sbjct: 1603 QLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLR 1662

Query: 417  CKRDKSVNSHS--FQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAE--------- 465
              RD+         Q+G         R  K  + ++     + E   L+ E         
Sbjct: 1663 HDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELE 1722

Query: 466  -RHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEV 524
             + R E++ ++E E ++  R  R  K +  E L+   +E +     L++Q   +  + E 
Sbjct: 1723 RKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQ-----LRRQERDRKFREE- 1776

Query: 525  LDNGVSEGADNKELAMKAESGPNETKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHK 581
                       ++L  + E     ++  D K    ++L       + +P  +D +++
Sbjct: 1777 -----------EQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYR 1822



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 44/246 (17%), Positives = 104/246 (42%), Gaps = 16/246 (6%)

Query: 283 RLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERI-----NSSWEKETPGERSHSRVDS 337
           R +G  EK    + + E +   F+   + +++             ++E P  +   + + 
Sbjct: 219 RRKGREEKQ---QQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEE 275

Query: 338 QSDKKLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRR--SERASLPHSKN 395
           +  +KLERQ  R +    ++ + + + E+++ +K +   ++Q   RR   ER      + 
Sbjct: 276 EQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERR 335

Query: 396 EITFSHNSSKYHLEE-RRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAM 454
           E        +   ++ RR  E+ +R++ +     ++ R    L   +  +       +  
Sbjct: 336 EQQLRREQEERREQQLRREQEEERREQQLRREQ-EEERREQQLRREQQLRREQQLRREQQ 394

Query: 455 HQWENTPLKAERHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQ 514
            + E    + ++ R E + +REQ+ + E +  R ++     H QK  +E ++    LK++
Sbjct: 395 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQEE--ERHEQKHEQERREQR--LKRE 450

Query: 515 NEPKTD 520
            E + D
Sbjct: 451 QEERRD 456



 Score = 39.3 bits (90), Expect = 0.039
 Identities = 50/317 (15%), Positives = 122/317 (38%), Gaps = 46/317 (14%)

Query: 231 HYQVGEGSSNEDSRRGR--------KDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQ 282
           +Y +G+ +  ++ +R R        +D R  +  R  E   + L    G    +  +  +
Sbjct: 86  YYALGQATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQE 145

Query: 283 RLQGHPEKYGKGEPKTESKS------------SKFKSNSDSDYKGERINSSWEKET---P 327
           R     E+  + + + E +              +++   +   + E++ S    ET   P
Sbjct: 146 RELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFP 205

Query: 328 GERSHSRVDSQSDKKLERQSERSQNINRKEVKSQDKEER------------------KVD 369
            E    R +    ++  R+ ++ Q   R++   Q++EE+                  +  
Sbjct: 206 DEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEP 265

Query: 370 QKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQ 429
           Q+ + + ++++  R+ ER  L   + E        +   + RR  E+ +R++       Q
Sbjct: 266 QRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQ 325

Query: 430 DGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESKEENRHIRNE 489
           + R        R  + +  ++ +   Q      + E  R E + +REQE +   + +R E
Sbjct: 326 ERR---EQQEERREQQLRREQEERREQ--QLRREQEEERREQQLRREQEEERREQQLRRE 380

Query: 490 KRVPTEHLQKTNKETKK 506
           +++  E   +  ++ ++
Sbjct: 381 QQLRREQQLRREQQLRR 397



 Score = 38.1 bits (87), Expect = 0.086
 Identities = 57/340 (16%), Positives = 127/340 (37%), Gaps = 28/340 (8%)

Query: 236  EGSSNEDSRRGRKDIRHSQ---FNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYG 292
            +G   +  RR  ++ R  Q   +    ER R+  +          L   Q+L    E+  
Sbjct: 854  DGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEE-- 911

Query: 293  KGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQN 352
              E + E +  + +   +  Y+        E+E   +     +  + +K+  ++ ER   
Sbjct: 912  --ELQREEREKRRRQEQERQYR--------EEEQLQQEEEQLLREEREKRRRQERERQY- 960

Query: 353  INRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERR 412
              RK+ K Q KEE+ + ++P+   + +   +  E   L   + ++       +   E  R
Sbjct: 961  --RKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWER 1018

Query: 413  GW----EDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHR 468
             +    E  + ++ +     +  R        R  + +  +E   + +   T  + E  R
Sbjct: 1019 QYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELER 1078

Query: 469  TEDKRKREQESKEENRHIRNE----KRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEV 524
                RK E+  +EE + +R E    +R   E   +  +E ++    L ++   K  + E+
Sbjct: 1079 --QYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQEL 1136

Query: 525  LDNGVSEGADNKELAMKAESGPNETKNKDLKLSFMKKLNL 564
                  E    +E        P + + ++L+  + ++  L
Sbjct: 1137 ERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEEL 1176


>gi|6631100 natural killer-tumor recognition sequence [Homo sapiens]
          Length = 1462

 Score = 59.3 bits (142), Expect = 4e-08
 Identities = 188/1001 (18%), Positives = 333/1001 (33%), Gaps = 179/1001 (17%)

Query: 149  NHKTARTFDTVKTKDLKSRSPHLDDCSKTDHRAKSDVSKDVHHSTSLPNLEKEGKPHSDK 208
            +HK  R    VK K    +  H     +T  R +  +  D+  S S     +  K   D+
Sbjct: 426  HHKKRRKEKKVKHKKKGKKQKHCRRHKQTKKR-RILIPSDIESSKSST---RRMKSSCDR 481

Query: 209  RSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDIRHSQ-FNRGTERVRKDLS 267
              +S   +    H +   WS+S   V + S    SR   +   HSQ ++RG+ R R   S
Sbjct: 482  ERSSRSSSLSSHHSSKRDWSKSDKDV-QSSLTHSSRDSYRSKSHSQSYSRGSSRSRT-AS 539

Query: 268  TGCGDGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERIN-------- 319
                    R    S    GH ++  K   KT S+ S+ K       +             
Sbjct: 540  KSSSHSRSRSKSRSSSKSGHRKRASKSPRKTASQLSENKPVKTEPLRATMAQNENVVVQP 599

Query: 320  -----------------SSWEK-ETPGERSHSRVD------------------------- 336
                             S W+  + P + S+ R+                          
Sbjct: 600  VVAENIPVIPLSDSPPPSRWKPGQKPWKPSYERIQEMKAKTTHLLPIQSTYSLANIKETG 659

Query: 337  -SQSDKKLERQSERSQNINRK-EVKSQDKEERKVDQKPKSVVKDQDHWR-RSERASLPHS 393
             S S  K E+ SE  Q+   K   +S +   R   +  +S    + + R RS  +S   S
Sbjct: 660  SSSSYHKREKNSESDQSTYSKYSDRSSESSPRSRSRSSRSRSYSRSYTRSRSLASSHSRS 719

Query: 394  KNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGR------CPSSLSNSRTHKNID 447
            ++  + SH+ +KY    +     C R  S  S S  DGR        S   NS +HK   
Sbjct: 720  RSPSSRSHSRNKYSDHSQ-----CSRSSSYTSISSDDGRRAKRRLRSSGKKNSVSHKKHS 774

Query: 448  SKEVDAMH-----------------------------------------------QWENT 460
            S     +H                                               Q E T
Sbjct: 775  SSSEKTLHSKYVKGRDRSSCVRKYSESRSSLDYSSDSEQSSVQATQSAQEKEKQGQMERT 834

Query: 461  PLKAERHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTD 520
              K E++R E+K K E+E     +  R  K   ++HL+  +K  +K     K  +E  ++
Sbjct: 835  HNKQEKNRGEEKSKSERECPHSKK--RTLKENLSDHLRNGSKPKRKNYAGSKWDSESNSE 892

Query: 521  KGEVLDNGVSEG--ADNKELAMKAESGPNETKNKDLKLSFMKKLNLTLSPAKKQPVSQDN 578
            + +V  N  ++   + +KE         +E     +K+    K +   S        + +
Sbjct: 893  R-DVTKNSKNDSHPSSDKEEGEATSDSESEVSEIHIKVKPTTKSSTNTSLPDDNGAWKSS 951

Query: 579  QHKITDIPKSSGVCDSESSMQVKTVAYVPSISEHILGE--AAVSEHTMGETKSTLLEPKV 636
            + + T    S G C +  + + K   +     E++  E    V E   G+       PK 
Sbjct: 952  KQR-TSTSDSEGSCSNSENNRGKPQKHKHGSKENLKREHTKKVKEKLKGKKDKKHKAPKR 1010

Query: 637  ALLAVTEPRIGISETNKED----------------ENSLLVRS--VDNTMHCEEPICGTE 678
                  +P +   E  +E+                EN+  ++   +      EE + G  
Sbjct: 1011 KQAFHWQPPLEFGEEEEEEIDDKQVTQESKEKKVSENNETIKDNILKTEKSSEEDLSGKH 1070

Query: 679  TSFPSPMEIQQTESLFPSTGMKQTINNGRAAAPVVMDVLQTDVSQNFGLELDTKRNDNSD 738
             +     ++ Q         +  T  N       + ++   + S   G+E   + +DN +
Sbjct: 1071 DTVTVSSDLDQFTKDDSKLSISPTALNTEENVACLQNIQHVEESVPNGVEDVLQTDDNME 1130

Query: 739  YCGISEGMEMKVALSTTVSETTESILQPSIEEADILPIMLSED---NNPKFEPSVIVTPL 795
             C        KV       E T  +    ++  DI  I+L +D    +P+ E     + +
Sbjct: 1131 ICTPDRSSPAKV-------EETSPLGNARLDTPDI-NIVLKQDMATEHPQAEVVKQESSM 1182

Query: 796  VESKSCHLEPCLPKETLDSSLQQTELMDHRMATGETNSVYHDDDNSVLSIDLNHLRPIPE 855
             ESK            L    +Q        + GE+       + S +++     +P+ +
Sbjct: 1183 SESK-----------VLGEVGKQDSSSASLASAGESTGKKEVAEKSQINLIDKKWKPL-Q 1230

Query: 856  AISPLNSPVRPVA-----KVLRN--ESPPQVPVYNNSHKDVFLPNSAHSTSKSQSDLNKE 908
             +  L +P    +     KVL    E  PQ        K+   P S     +  + LN+ 
Sbjct: 1231 GVGNLAAPNAATSSAVEVKVLTTVPEMKPQGLRIEIKSKNKVRPGSLFDEVRKTARLNRR 1290

Query: 909  NQKPIYKSDKCT---EADTCKNSPLDELEEGEIRSDSETSKPQESFEKNSKRRVSADVRK 965
             +     SD+ T   + D+   SP     + E +S   T     S  ++  R  ++  R 
Sbjct: 1291 PRNQESSSDEQTPSRDDDSQSRSPSRSRSKSETKSRHRTRSVSYSHSRSRSRSSTSSYRS 1350

Query: 966  SKTIPRRGKSTVCLDKD-SRKTHVRIHQTNNKWNKRPDKSS 1005
                  R +      +  SR +  R ++++   ++   +SS
Sbjct: 1351 RSYSRSRSRGWYSRGRTRSRSSSYRSYKSHRTSSRSRSRSS 1391



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 79/406 (19%), Positives = 143/406 (35%), Gaps = 54/406 (13%)

Query: 160 KTKDLKSRSPHLDDCSKTDHRAKSDVSKDVHHSTSLPNLEKE------GKPHSDKRSTSH 213
           K +   + S   D  S +   ++S    ++ H  S     K        K    + S+S 
Sbjct: 187 KKRKKPTHSEGSDSSSNSSSSSESSSESELEHERSRRRKHKRRPKVKRSKKRRKEASSSE 246

Query: 214 LPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDI-RHSQFNRGTER---VRKDLSTG 269
            P +  KH  N           E  S + S +  K + R  +     E    +R+D+   
Sbjct: 247 EPRN--KHAMNPKGHSERSDTNEKRSVDSSAKREKPVVRPEEIPPVPENRFLLRRDMPVV 304

Query: 270 CGDGEPRILEASQRLQGHPEKYGKGEPKTESKS---------SKFKSNSDSDYKGE---- 316
             + EP+I + +  +        K   K + +          S+  S SD D   E    
Sbjct: 305 TAEPEPKIPDVAPIVSDQKPSVSKSGRKIKGRGTIRYHTPPRSRSCSESDDDDSSETPPH 364

Query: 317 ------RINS----SWEKETPGERSHSRVDSQSDKKLERQSERSQNIN----------RK 356
                 R+ +    S EK + G++      S+ D++   Q  RS + N            
Sbjct: 365 WKEEMQRLRAYRPPSGEKWSKGDKLSDPCSSRWDERSLSQRSRSWSYNGYYSDLSTARHS 424

Query: 357 EVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWED 416
               + ++E+KV  K K   K Q H RR ++      K  I    +        RR    
Sbjct: 425 GHHKKRRKEKKVKHKKKG--KKQKHCRRHKQTK----KRRILIPSDIESSKSSTRRMKSS 478

Query: 417 CKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKRE 476
           C R++S  S S       S    S++ K++ S    +      +   ++ +     R R 
Sbjct: 479 CDRERSSRSSSLSSHHS-SKRDWSKSDKDVQSSLTHSSRDSYRSKSHSQSYSRGSSRSRT 537

Query: 477 QESKEENRHIRNEKRVPTE--HLQKTNKETKKTTTDLKKQNEPKTD 520
                 +   R++ R  ++  H ++ +K  +KT + L +    KT+
Sbjct: 538 ASKSSSHSRSRSKSRSSSKSGHRKRASKSPRKTASQLSENKPVKTE 583



 Score = 40.8 bits (94), Expect = 0.013
 Identities = 88/362 (24%), Positives = 132/362 (36%), Gaps = 71/362 (19%)

Query: 1163 EGKLEKT----SKQNAQYSNSQKRSVDNSNRELLKEKLSKSEDPVHYKSLVGCKKSEENY 1218
            +G++E+T     K   +  +  +R   +S +  LKE LS      H ++  G K   +NY
Sbjct: 828  QGQMERTHNKQEKNRGEEKSKSERECPHSKKRTLKENLSD-----HLRN--GSKPKRKNY 880

Query: 1219 QDQNNSSINTVKHDIKKNFNICFDNIKNSQSEERSLEVHCPSTPKSEKNEGSSIEDAQTS 1278
                  S +  + D+ KN        KN             S P S+K EG +  D+++ 
Sbjct: 881  AGSKWDSESNSERDVTKNS-------KND------------SHPSSDKEEGEATSDSESE 921

Query: 1279 Q---HATLKPERSFEILTEQQASSLTFNLVSDAQMGEIFKSLLQGSDLLDSSVNCTEKSE 1335
                H  +KP            SS   +L  D      +KS  Q +   DS  +C+  SE
Sbjct: 922  VSEIHIKVKPTTK---------SSTNTSLPDD---NGAWKSSKQRTSTSDSEGSCSN-SE 968

Query: 1336 WELKTPEKQL---LETLKCESIPACTTEELVSGVASP---CPKMISDDNWSLLSSEKGPS 1389
                 P+K      E LK E       +E + G        PK     +W        P 
Sbjct: 969  NNRGKPQKHKHGSKENLKREHTKK--VKEKLKGKKDKKHKAPKRKQAFHWQ-------PP 1019

Query: 1390 LSSGLSLPVHPD---VLDESCMFEVSTNLPLSKDNVCSVEKSKPCVSSILLEDLAVSLTV 1446
            L  G       D   V  ES   +VS N    KDN+   EKS     S   + + VS  +
Sbjct: 1020 LEFGEEEEEEIDDKQVTQESKEKKVSENNETIKDNILKTEKSSEEDLSGKHDTVTVSSDL 1079

Query: 1447 PSPLKSDGHLSFLKPDMSSSSTPEEVIS----AHFSEDALLEEEDASEQDIHLALESDNS 1502
                K D  LS      ++ +T E V       H  E      ED  + D ++ + + + 
Sbjct: 1080 DQFTKDDSKLSI---SPTALNTEENVACLQNIQHVEESVPNGVEDVLQTDDNMEICTPDR 1136

Query: 1503 SS 1504
            SS
Sbjct: 1137 SS 1138



 Score = 38.9 bits (89), Expect = 0.051
 Identities = 58/313 (18%), Positives = 116/313 (37%), Gaps = 52/313 (16%)

Query: 91   MKKFKEIQTQ-NFSLINENQSLKKNISALIKTARVEINRK-DEEISNLHQRLS----EFP 144
            ++K+ E ++  ++S  +E  S++   SA  K  + ++ R  +++  N  +  S    E P
Sbjct: 795  VRKYSESRSSLDYSSDSEQSSVQATQSAQEKEKQGQMERTHNKQEKNRGEEKSKSERECP 854

Query: 145  HFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHRAKSDVSKDVHHSTSLPNLEKEGKP 204
            H +         D ++      R  +      ++  ++ DV+K+  + +   + ++EG+ 
Sbjct: 855  HSKKRTLKENLSDHLRNGSKPKRKNYAGSKWDSESNSERDVTKNSKNDSHPSSDKEEGEA 914

Query: 205  HSDKRS-----------TSHLPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDIRHS 253
             SD  S           T+   T+      NG W  S     + +S  DS        +S
Sbjct: 915  TSDSESEVSEIHIKVKPTTKSSTNTSLPDDNGAWKSSK----QRTSTSDS---EGSCSNS 967

Query: 254  QFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDY 313
            + NRG  +  K                      H  K       T+    K K   D  +
Sbjct: 968  ENNRGKPQKHK----------------------HGSKENLKREHTKKVKEKLKGKKDKKH 1005

Query: 314  KGERINSSWEKETP---GERSHSRVDSQ---SDKKLERQSERSQNINRKEVKSQDKEERK 367
            K  +   ++  + P   GE     +D +    + K ++ SE ++ I    +K++   E  
Sbjct: 1006 KAPKRKQAFHWQPPLEFGEEEEEEIDDKQVTQESKEKKVSENNETIKDNILKTEKSSEED 1065

Query: 368  VDQKPKSVVKDQD 380
            +  K  +V    D
Sbjct: 1066 LSGKHDTVTVSSD 1078


>gi|239747174 PREDICTED: hypothetical protein XP_002343931, partial
           [Homo sapiens]
          Length = 213

 Score = 58.9 bits (141), Expect = 5e-08
 Identities = 38/200 (19%), Positives = 92/200 (46%), Gaps = 2/200 (1%)

Query: 323 EKETPGERSHSRVDSQSDKKLERQSERSQNINR-KEVKSQDKEERKVDQKPKSVVKDQDH 381
           E +T G  +H+  ++  D++ ER+ E  +  +R KE K++D+   +  Q+ +   +++D 
Sbjct: 2   ESKTEGRHTHTETETM-DRQRERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDR 60

Query: 382 WRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSR 441
            R  E+ +    + +     +  +    ER   ++ + D+   +   +  +    +   R
Sbjct: 61  DREREKQTDREGERQRERERDRDRQRETERERDKERETDRHTETDRERQKQKEREMERVR 120

Query: 442 THKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTN 501
             +    KE+    Q +    +    + E +R+  +E K E+RH   E+    E  +K  
Sbjct: 121 DREREKQKEMGRERQTDRETDRERERQAERERETGRERKTEDRHRERERERKRERERKRE 180

Query: 502 KETKKTTTDLKKQNEPKTDK 521
            + ++  TD++++ + +TD+
Sbjct: 181 TKERERHTDMERERQRETDR 200


>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 245

 Score = 57.8 bits (138), Expect = 1e-07
 Identities = 43/201 (21%), Positives = 88/201 (43%), Gaps = 10/201 (4%)

Query: 323 EKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHW 382
           +KE   ER   R + +  K+ ER+ ER +   +KE K + K+E +  +K +   ++++  
Sbjct: 52  KKERESERKKERREREKRKR-EREKERKRERGKKEKKGERKKEERERKKRRREKENKEGE 110

Query: 383 RRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRT 442
            + +R      +   T      +   EER+  E  +R++       +  R        R 
Sbjct: 111 EKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERER---KERKKRE 167

Query: 443 HKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNK 502
            K +  KE +   +      K ER+R E K++RE++ + E +  R +K       ++  +
Sbjct: 168 RKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKE------ERKKE 221

Query: 503 ETKKTTTDLKKQNEPKTDKGE 523
             K   T+ +++   K ++ E
Sbjct: 222 RQKDRQTNWREKERGKRERKE 242



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 37/159 (23%), Positives = 68/159 (42%), Gaps = 17/159 (10%)

Query: 236 EGSSNEDSRRGRKDIRHSQFNRGTERVR------KDLSTGCGDGEPRILEASQRLQGHPE 289
           +G   ++ R  +K  R  +   G E+ +      K+      +G+ R  +  ++ +   E
Sbjct: 87  KGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKE 146

Query: 290 KYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSER 349
           +  K E + + +  K +   +    GE+     EKE    +   R       + ER+ ER
Sbjct: 147 RERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRER------NRKERKKER 200

Query: 350 SQNINRKEVKSQDKEERKVDQKPKSVVKD-QDHWRRSER 387
                RKE + + KE +K +++ K   KD Q +WR  ER
Sbjct: 201 ----ERKERRERKKERKKKEERKKERQKDRQTNWREKER 235



 Score = 45.8 bits (107), Expect = 4e-04
 Identities = 48/215 (22%), Positives = 84/215 (39%), Gaps = 13/215 (6%)

Query: 218 VEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRI 277
           + K CT   W     ++ E     ++R+  K  R S+  R  ER  ++      + E + 
Sbjct: 25  ISKPCTQPGWQS---EIREREREIETRKEGKKERESE--RKKERREREKRKREREKERK- 78

Query: 278 LEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDS 337
                R +G  EK  KGE K E +  K +     + +GE      +KE       S+   
Sbjct: 79  -----RERGKKEK--KGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGK 131

Query: 338 QSDKKLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEI 397
           + ++K ER+ E  +   RK+ + + + ERK  +K +     +    R E+      K E 
Sbjct: 132 ERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRER 191

Query: 398 TFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGR 432
                  +   +ERR  +  ++ K       Q  R
Sbjct: 192 NRKERKKERERKERRERKKERKKKEERKKERQKDR 226



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 33/127 (25%), Positives = 52/127 (40%), Gaps = 1/127 (0%)

Query: 241 EDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTES 300
           E   RGR      +  R  ER R++        E R  E  ++ +   E+   GE + E 
Sbjct: 119 EKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEER 178

Query: 301 KSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKS 360
           K  + K     +   +      E++   ER   R   +  KK ERQ +R  N   KE   
Sbjct: 179 KEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKK-ERQKDRQTNWREKERGK 237

Query: 361 QDKEERK 367
           ++++ERK
Sbjct: 238 RERKERK 244



 Score = 36.2 bits (82), Expect = 0.33
 Identities = 24/100 (24%), Positives = 46/100 (46%), Gaps = 4/100 (4%)

Query: 457 WENTPLKAERH---RTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKK 513
           W++   + ER    R E K++RE E K+E R  R +++   E  +K  +  K+   + KK
Sbjct: 34  WQSEIREREREIETRKEGKKERESERKKERRE-REKRKREREKERKRERGKKEKKGERKK 92

Query: 514 QNEPKTDKGEVLDNGVSEGADNKELAMKAESGPNETKNKD 553
           +   +  +    +N   E  + ++   K E G    + K+
Sbjct: 93  EERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKE 132



 Score = 35.4 bits (80), Expect = 0.56
 Identities = 24/93 (25%), Positives = 44/93 (47%), Gaps = 2/93 (2%)

Query: 463 KAERHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKG 522
           K ER R  +KRKRE+E + +    + EK+   +  ++  K+ ++   + + + + K  K 
Sbjct: 60  KKER-REREKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKK 118

Query: 523 EVLDNGVSEGADNKELAMKAESGPNETKNKDLK 555
           E  + G     + KE   K E    E K ++ K
Sbjct: 119 EKKERG-RTSKEGKERERKEERKREERKERERK 150


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 94/498 (18%), Positives = 176/498 (35%), Gaps = 64/498 (12%)

Query: 165 KSRSPHLDDCSKTDHRAKSDVSKDVHHSTSLPNLEKE-----------GKPHSDKRSTSH 213
           +++SP  ++ +  +  AKS V ++        + EKE            K  S  +  + 
Sbjct: 500 ETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAK 559

Query: 214 LPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDG 273
            P   +        S +  +  E + +      +         +    V+++  +     
Sbjct: 560 SPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAK 619

Query: 274 EPRILEASQRLQGHPEKYGKGEPKTESKS-SKFKSNSDSDYKG-ERINSSWEKETPG-ER 330
            P   EA    +    +  K   K E+KS  K KS    + K  E+  S  + E    E+
Sbjct: 620 SPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEK 679

Query: 331 SHSRVDSQSD---------KKLERQSERSQNINRKEVKSQD------KEERKVDQKPKSV 375
           + S V +++          K+  +  E++++  ++E KS +      KEE K  +K KS 
Sbjct: 680 AKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSP 739

Query: 376 VKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRG--------------WEDCKRDK 421
           VK++   +  E+A  P     +      +K   +E                  E+ K  +
Sbjct: 740 VKEEA--KSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPE 797

Query: 422 SVNSHSFQDGRCP-----------SSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTE 470
              S   +D + P           S +      + +  KE     + E  P   +    +
Sbjct: 798 KAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKK 857

Query: 471 DKRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVS 530
           D +K E   KE  +    EK+ P     K +K   K      K+  P  +K       V 
Sbjct: 858 DSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVK 917

Query: 531 EGADNKELAMKAESGPNETKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITDIPKSSG 590
           E A  KE    A+  P++ K K+      KK        +  P  +D + +    P+   
Sbjct: 918 EDAKPKEKTEVAKKEPDDAKAKEPSKPAEKK--------EAAPEKKDTKEEKAKKPEEKP 969

Query: 591 VCDSESSMQVKTVAYVPS 608
             ++++    KT++  PS
Sbjct: 970 KTEAKAKEDDKTLSKEPS 987



 Score = 45.8 bits (107), Expect = 4e-04
 Identities = 91/493 (18%), Positives = 169/493 (34%), Gaps = 40/493 (8%)

Query: 199 EKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRG 258
           E EG     K   +    S EK   + V   +       S  ++  +   +++  +  + 
Sbjct: 493 EAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPE--KA 550

Query: 259 TERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTESKS---SKFKSNSDSDYKG 315
               +++  +      P   EA    +    +  K   K E+KS   +K    + S  K 
Sbjct: 551 KSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKE 610

Query: 316 ERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKSQDKEERKVDQKPKSV 375
           E  + +  K    E + S  + +S +K +  ++       K  KS +KEE K  +K KS 
Sbjct: 611 EAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEK-AKSPEKEEAKSPEKAKSP 669

Query: 376 VKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPS 435
           VK +   +  E+A  P  K E      +     EE +  E  K      + S +  + P 
Sbjct: 670 VKAEA--KSPEKAKSP-VKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPV 726

Query: 436 SLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESKEENRHIRNEKRVPTE 495
                +       K    + +   +P KA+    E  +  + +S E     + E R P +
Sbjct: 727 -----KEEAKTPEKAKSPVKEEAKSPEKAKS--PEKAKTLDVKSPEAKTPAKEEARSPAD 779

Query: 496 HL-QKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAMKAESGPNETKNKDL 554
              +K     K+     +K   P  +  +  +  + +  + K   +K E  P E K    
Sbjct: 780 KFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKS-PVKEEEKPQEVK---- 834

Query: 555 KLSFMKKLNLTLSPAKKQPVSQDNQHKITDIPKSSGVCDSESSMQVKTVAYVPSISEHIL 614
                           K+P  +  + K    PK+    DS+     K  A  P + E   
Sbjct: 835 ---------------VKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKE 879

Query: 615 GEAAVSEHTMGETKSTLLEPKVALLAVTE---PRIGISETNKEDENSLLVRSVDNTMHCE 671
                 + +  E K    E K  +    +    ++ + E  K  E + + +   +    +
Sbjct: 880 PAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAK 939

Query: 672 EPICGTETSFPSP 684
           EP    E    +P
Sbjct: 940 EPSKPAEKKEAAP 952



 Score = 43.9 bits (102), Expect = 0.002
 Identities = 86/427 (20%), Positives = 158/427 (37%), Gaps = 32/427 (7%)

Query: 272 DGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERS 331
           +G P+I   S  ++   E+  K   K+E ++   +  ++     E +    EKE   E  
Sbjct: 424 EGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEG 483

Query: 332 HSRVDSQSDKKLERQSERSQN-------INRKEVKSQDKEERKVDQKPKSVVKDQ----D 380
               +   +++ E   E +++          KE KS  KEE K   + KS  K++     
Sbjct: 484 KEE-EGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPA 542

Query: 381 HWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNS 440
             +  E+A  P +K E      +     EE +   + K  +   S + ++ + P+   + 
Sbjct: 543 EVKSPEKAKSP-AKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSP 601

Query: 441 RTHKNIDSKEVDAMHQWENTPLKAER---------HRTEDKRKREQESKEENRHIRNEKR 491
              K+   +E  +  +   +P+K E           + +   K E +S E+ +    E+ 
Sbjct: 602 EKAKSPVKEEAKSPAE-AKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEA 660

Query: 492 VPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAMKAESG-PNETK 550
              E  +   K   K+    K   + +    E   + V E A + E   KA+S    E K
Sbjct: 661 KSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPE---KAKSPVKEEAK 717

Query: 551 NKDLKLSFMKKLNLTLSPAK---KQPVSQDNQHKITDIPKSSGVCDSESSMQVKTVAYVP 607
           + +   S +K+   T   AK   K+      + K  +  K+  V   E+    K  A  P
Sbjct: 718 SPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSP 777

Query: 608 SISEHILGEAAVSEHTMG--ETKSTLLEPKVALLAVTEPRIGISETNKEDENSLLVRSVD 665
           +       ++ V E      + KS L E   A       +  +    KE+E    V+  +
Sbjct: 778 ADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKE 837

Query: 666 NTMHCEE 672
                EE
Sbjct: 838 PPKKAEE 844



 Score = 40.8 bits (94), Expect = 0.013
 Identities = 50/259 (19%), Positives = 100/259 (38%), Gaps = 25/259 (9%)

Query: 288  PEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLE--- 344
            PE     + +  S + KF   + S  K E + S  + ++P +      + +  KK E   
Sbjct: 764  PEAKTPAKEEARSPADKFPEKAKSPVK-EEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKS 822

Query: 345  --RQSERSQNINRKEVKSQDKEER---------KVDQKPKSVVKDQDHWRRSERASLPHS 393
              ++ E+ Q +  KE   + +EE+         K D K +   K +    + E    P  
Sbjct: 823  PVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAV 882

Query: 394  KNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDA 453
            +        + K   E+++     +++        +D + P   +     +  D+K  + 
Sbjct: 883  EKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAK-PKEKTEVAKKEPDDAKAKEP 941

Query: 454  MHQWENTPLKAERHRT--------EDKRKREQESKEENRHIRNEKRVP-TEHLQKTNKET 504
                E      E+  T        E+K K E ++KE+++ +  E   P  E  +K++   
Sbjct: 942  SKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTD 1001

Query: 505  KKTTTDLKKQNEPKTDKGE 523
            +K +   +K  E K  KG+
Sbjct: 1002 QKDSKPPEKATEDKAAKGK 1020



 Score = 35.8 bits (81), Expect = 0.43
 Identities = 98/498 (19%), Positives = 170/498 (34%), Gaps = 69/498 (13%)

Query: 1461 PDMSSSSTPEEVISAHFSEDALLEEEDASEQDIHLALESDNSSSKSSCSSSWTSRSVAPG 1520
            P    +++PE+   +   E+A    E  S        E + + S +   S   ++S A  
Sbjct: 504  PPAEEAASPEKEAKSPVKEEAKSPAEAKSP-------EKEEAKSPAEVKSPEKAKSPA-- 554

Query: 1521 FQYHPNLPMHAVIMEKSNDHFIVKIRRATPSTSSGLKQSMMPDELLTSLPRHGKEADEGP 1580
             +     P  A   EK       +++    + S   +++  P E  +       E  + P
Sbjct: 555  -KEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSP------EKAKSP 607

Query: 1581 EKEYISCQNTVFKSVEELENSN---KNVDGSKS-THEEQSSMIQTQVPDIYEFLKDASDK 1636
             KE           V+E   S    K+ + +KS T EE  S  + + P+  E       K
Sbjct: 608  VKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAK 667

Query: 1637 MGHSDEV-ADECFKLHQVWETKVPESI-----EELPSMEEISHSVGEHLPNTYVDLTKDP 1690
                 E  + E  K     E K PE       EE  S E+    V E   +   +  K P
Sbjct: 668  SPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSP--EKAKSP 725

Query: 1691 VTETKNLGEFIEVTVLHIDQLGCSGGNLNQSAQILDNSLQADTVGAFIDLTQDASSEAKS 1750
            V E     E  +  V              + A+  + +   +        + +A + AK 
Sbjct: 726  VKEEAKTPEKAKSPV-------------KEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKE 772

Query: 1751 EGNHPALAVEDLGCGVIQVDEDNCKEEKAQV---ANRPLKCIVEETYIDLTTESPSSCEV 1807
            E   PA    +     ++ +  + ++ K+ +   A  P K I ++  +    +SP   E 
Sbjct: 773  EARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEV----KSPVKEEE 828

Query: 1808 KKDELK-SEPGSNCDNSELPGTLHNSHKK-------------RRNISDLNHP-------H 1846
            K  E+K  EP    +  + P T     KK             +  + +   P        
Sbjct: 829  KPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKES 888

Query: 1847 KKQRKETDLTNKEKTKKPTQDSCENTEAHQKKASKKKAPPVTKDPSSLKATPGIKDSSAA 1906
            K + K+ +  +K+K   P +++    E  +    K+K     K+P   KA    K +   
Sbjct: 889  KVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKK 948

Query: 1907 LATSTSLSAKNVIKKKGE 1924
             A       K    KK E
Sbjct: 949  EAAPEKKDTKEEKAKKPE 966



 Score = 34.7 bits (78), Expect = 0.95
 Identities = 136/748 (18%), Positives = 249/748 (33%), Gaps = 79/748 (10%)

Query: 302  SSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKSQ 361
            S   K N+D+    +   + + ++     +       +   LERQ    ++ ++ ++ S 
Sbjct: 301  SEAAKVNTDAMRSAQEEITEYRRQLQARTTELEALKSTKDSLERQRSELEDRHQADIASY 360

Query: 362  DKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRDK 421
             +  +++D + ++   +     R E   L + K  +     + +  LE     E+C+   
Sbjct: 361  QEAIQQLDAELRNTKWEMAAQLR-EYQDLLNVKMALDIEIAAYRKLLEG----EECRIGF 415

Query: 422  SVNSHSFQDGRCPSSLSNSRTHKNIDSKE------------VDAMHQWENTPLKAERHRT 469
                 S  +G     + +  TH  + S+E            V    Q E T +  E    
Sbjct: 416  GPIPFSLPEGL--PKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEE 473

Query: 470  EDKRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGV 529
            E+K  +E+E KE       E+    E  +   +ETK    +  +   P+ +    +    
Sbjct: 474  EEKEAKEEEGKE-------EEGGEEEEAEGGEEETKSPPAE--EAASPEKEAKSPVKEEA 524

Query: 530  SEGADNKELAMKAESGPNETKNKDLKLSFMKKLNLTLSPAK---KQPVSQDNQHKITDIP 586
               A+ K    +    P E K+ +   S  K+   +   AK   K+      + K  +  
Sbjct: 525  KSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKA 584

Query: 587  KSSGVCDSESSMQVKTVAYVPSISEHILGEAAVSEHTMGETKSTLLEPKVALLAVTEPRI 646
            KS    +++S  + K+    P  ++  + E A S     E KS + E   +   V  P  
Sbjct: 585  KSPAKEEAKSPAEAKS----PEKAKSPVKEEAKSP---AEAKSPVKEEAKSPAEVKSPEK 637

Query: 647  GISETNKEDENSLLVRSVDNTMHCEEPICGTETSFPSPMEIQQTESLFPSTGMKQTINNG 706
              S T +E       +S +     E+    +     SP++ +        + +K    + 
Sbjct: 638  AKSPTKEE------AKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSP 691

Query: 707  RAAAPVVMDVLQTDVSQNFGLELDTKRNDNSDYCGISEGMEMKVALSTTVSETTESILQP 766
              A   V +  ++       ++ + K  + +      E    + A S    E        
Sbjct: 692  EKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAK 751

Query: 767  SIEEADILPIMLSEDNNPKFEPSVIVTPLVESKSCHLEPCLPKETLDSSLQQTELMDHRM 826
            S E+A  L +   E   P  E +         K+        KE + S  +    +    
Sbjct: 752  SPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKA----KSPVKEEVKSPEKAKSPLKEDA 807

Query: 827  ATGETNSVYHDDDNSVLSIDLNHLRPIPEAISPLNSPVRPVAKVLRNESPPQVP--VYNN 884
               E      ++  S          P+ E   P    V+   K    E  P  P      
Sbjct: 808  KAPEKEIPKKEEVKS----------PVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKK 857

Query: 885  SHKDVFLPNSAHSTSKSQSDLNKENQKPIYK--SDKCTEADTCKNSPLDELEEGEIRSDS 942
              K    P       K +       +KP       K  EA+  K  P  E E        
Sbjct: 858  DSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVK 917

Query: 943  ETSKPQESFEKNSKRRVSADVRKSKTIPRRGKSTVCLDKDSR-----------KTHVRIH 991
            E +KP+E  E   K    A   K  + P   K      KD++           KT  +  
Sbjct: 918  EDAKPKEKTEVAKKEPDDAKA-KEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAK 976

Query: 992  QTNNKWNKRP-----DKSSRSSKTEKKD 1014
            + +   +K P     +K+ +SS T++KD
Sbjct: 977  EDDKTLSKEPSKPKAEKAEKSSSTDQKD 1004



 Score = 32.7 bits (73), Expect = 3.6
 Identities = 37/151 (24%), Positives = 57/151 (37%), Gaps = 22/151 (14%)

Query: 1770 DEDNCKEEKAQVANRPLKCIVEETYIDLTTESPSSCEVKKDELKSEPGSNCDNSELPGTL 1829
            ++ + K+E+A     P   + E+    +     S  E KK+E + +        E P  +
Sbjct: 855  EKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKV 914

Query: 1830 HNSH-----------KKRRNISDLNHPHKKQRK-----ETDLTNKEKTKKPTQDSCENTE 1873
                           KK  + +    P K   K     E   T +EK KKP +     TE
Sbjct: 915  EVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEK--PKTE 972

Query: 1874 AHQKKASKKKAPPVTKDPSSLKATPGIKDSS 1904
            A  K+  K     ++K+PS  KA    K SS
Sbjct: 973  AKAKEDDK----TLSKEPSKPKAEKAEKSSS 999


>gi|50962882 G patch domain containing 8 [Homo sapiens]
          Length = 1502

 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 77/319 (24%), Positives = 121/319 (37%), Gaps = 27/319 (8%)

Query: 194 SLPNL-EKEGKPHSDKRSTSHLPTS--VEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDI 250
           SLP+  E+ GK H  K+   H  +S    KH  +     S  + GE S     R+ +K+ 
Sbjct: 661 SLPSKKERSGKSHRHKKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRKKN- 719

Query: 251 RHSQFNRGTERVRKDLSTGCGDGEP-----RILEASQRLQGHPEKYGKGEPKTESKSSKF 305
             S     +ER  K    G G   P     R  + SQR     E+   G+       S  
Sbjct: 720 -KSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSS 778

Query: 306 KSNSDSDYKGERINSSWEKETPGER----SHSRVDSQSDKKLERQSERSQNINRKEVKSQ 361
           + +    +KGE   SS ++    +R    SH    S  D+  +  S  S  +++K     
Sbjct: 779 QDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDAS--SHRLHQKSPSQY 836

Query: 362 DKEERKVD-------QKPKSVVKDQDH--WRRSERASLPHSKNEITFSHNSSKYHLEERR 412
            +EE + D        + +S  +   H   RRS  +S   S ++  +S   S Y  +   
Sbjct: 837 SEEEEEEDSGSEHSRSRSRSGRRHSSHRSSRRSYSSSSDASSDQSCYSRQRS-YSDDSYS 895

Query: 413 GWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDK 472
            + D  R  S  SH   D    SS   S+ HK   S + D       +  ++  H  E  
Sbjct: 896 DYSDRSRRHSKRSHDSDDSDYASSKHRSKRHK-YSSSDDDYSLSCSQSRSRSRSHTRERS 954

Query: 473 RKREQESKEENRHIRNEKR 491
           R R +         R+++R
Sbjct: 955 RSRGRSRSSSCSRSRSKRR 973



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 56/268 (20%), Positives = 100/268 (37%), Gaps = 30/268 (11%)

Query: 166  SRSPHLDDCSKTDHRAKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNG 225
            SRS H    S  D  +    S  +H  +     E+E +  S    +     S  +H ++ 
Sbjct: 805  SRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHR 864

Query: 226  VWSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQ 285
               RS+    + SS++     ++      ++  ++R R+         +     +  R +
Sbjct: 865  SSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSK 924

Query: 286  GHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLER 345
             H  KY               S+SD DY     + S  +     RSH+R  S+S     R
Sbjct: 925  RH--KY---------------SSSDDDY-----SLSCSQSRSRSRSHTRERSRS-----R 957

Query: 346  QSERSQNINRKEVKSQDKEERKVD-QKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSS 404
               RS + +R   K + +       Q+ +S  +D+    RS   S      + ++ H S 
Sbjct: 958  GRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRS--PSQRSGSRKRSWGHESP 1015

Query: 405  KYHLEERRGWEDCKRDKSVNSHSFQDGR 432
            +     RR +   K  +S + H F+ GR
Sbjct: 1016 EERHSGRRDFIRSKIYRSQSPHYFRSGR 1043



 Score = 39.3 bits (90), Expect = 0.039
 Identities = 62/282 (21%), Positives = 98/282 (34%), Gaps = 27/282 (9%)

Query: 130  DEEISNLHQRL-SEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHRAKSDVSKD 188
            D     LHQ+  S++        +       +++  +  S H    S+  + + SD S D
Sbjct: 822  DASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRS--SRRSYSSSSDASSD 879

Query: 189  VHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSNEDS----- 243
                +   +   +       RS  H   S +   ++   S+   +  + SS++D      
Sbjct: 880  QSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSC 939

Query: 244  ----RRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTE 299
                 R R   R    +RG  R     S+ C     R    S+    H  +  +   +  
Sbjct: 940  SQSRSRSRSHTRERSRSRGRSR-----SSSCS--RSRSKRRSRSTTAHSWQRSRSYSRDR 992

Query: 300  SKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVK 359
            S+S++    S S   G R   SW  E+P ER   R D    K    QS       R E  
Sbjct: 993  SRSTR----SPSQRSGSR-KRSWGHESPEERHSGRRDFIRSKIYRSQSPHYFRSGRGEGP 1047

Query: 360  SQDKEERKVDQK---PKSVVKDQDHWRRSERASLPHSKNEIT 398
             +  + R  D K   P S   +    R SE    P  KN +T
Sbjct: 1048 GKKDDGRGDDSKATGPPSQNSNIGTGRGSEGDCSPEDKNSVT 1089



 Score = 33.5 bits (75), Expect = 2.1
 Identities = 26/86 (30%), Positives = 42/86 (48%), Gaps = 5/86 (5%)

Query: 1800 ESPSSCEVKKDELKSEPG-SNCDNSELPGTLHNSHKKRRNISDLNHPHKKQRKETDLT-N 1857
            ++P+S        K EPG S+   +E  G    S K+R   S  +H HKK++K    + +
Sbjct: 631  DAPASGSACSGLNKQEPGGSHGSETEDTGRSLPSKKER---SGKSHRHKKKKKHKKSSKH 687

Query: 1858 KEKTKKPTQDSCENTEAHQKKASKKK 1883
            K K K  T++     E+ +K   +KK
Sbjct: 688  KRKHKADTEEKSSKAESGEKSKKRKK 713


>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 899

 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 85/498 (17%), Positives = 198/498 (39%), Gaps = 37/498 (7%)

Query: 59  EEILTEEGTAKEATYNDLQVEYGKCQLQMKELMKKFKEIQTQNFSLINENQSLKKNISAL 118
           EE + E+          ++ +  K   Q + L ++ K+++ Q   + ++ + + +    L
Sbjct: 347 EEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERL 406

Query: 119 IKTARVEINRKDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKD--LKSRSPHLDDCSK 176
            +  + E  R+ E++    +++ E    +   K  R  +    ++  ++ R   + +  +
Sbjct: 407 RE--KEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEE 464

Query: 177 TDHRAKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGE 236
           T    +  + K   +       E+E K    +R    LP   EK     +W +   Q  E
Sbjct: 465 TMREQEEKMQKQEENMW-----EQEEKEWQQQR----LPEQKEK-----LWEQEKMQEQE 510

Query: 237 GS--SNEDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKG 294
                 E+  R ++++   +     +   ++      + E ++ +  Q++    E+    
Sbjct: 511 EKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERM--- 567

Query: 295 EPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNIN 354
           E KT+ +  K     +   + ER+    +K    E      + +  ++ E+  E+ + + 
Sbjct: 568 EKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMW 627

Query: 355 RKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSH----NSSKYHLEE 410
            +E K Q++EE+  +Q+ K   +++  W   E+  LP  K ++ + H       K   +E
Sbjct: 628 EQEEKMQEQEEKMWEQEEKMWEQEEKMW---EQQRLPEQKEKL-WEHEKMQEQEKMQEQE 683

Query: 411 RRGWEDCKRDKSVNSH---SFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERH 467
            + WE  K +K        ++   +     S     K +  +E     Q E    + E+ 
Sbjct: 684 EKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKM 743

Query: 468 RTEDKRKREQESK--EENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVL 525
           + +++   EQE K  E+   +  ++R+P +  +    E  +    + +Q E   D+ E +
Sbjct: 744 QEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKM 803

Query: 526 DNGVSEGADNKELAMKAE 543
             G  E    +E  M+ +
Sbjct: 804 -RGQEEKMRGQEEKMRGQ 820



 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 49/249 (19%), Positives = 101/249 (40%), Gaps = 24/249 (9%)

Query: 274 EPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHS 333
           E  + E  ++++   EK  + E +   +  K +   +  ++ E+     EKE        
Sbjct: 278 EEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKEL------- 330

Query: 334 RVDSQSDKKLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHS 393
               + +K+L  Q E    +  +E + Q++EE+  +Q+ K   +++  WR+ ER      
Sbjct: 331 ---REQEKELREQKE----LREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERL----W 379

Query: 394 KNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKE--- 450
           + E        K   +E R WE  +R +       +  +    +   R  K +  +E   
Sbjct: 380 EQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKT 439

Query: 451 ---VDAMHQWENTPLKAERHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKT 507
               + M + E    + ++ R E++  REQE K + +     ++   E  Q+   E K+ 
Sbjct: 440 RDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEK 499

Query: 508 TTDLKKQNE 516
             + +K  E
Sbjct: 500 LWEQEKMQE 508



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 48/293 (16%), Positives = 110/293 (37%), Gaps = 53/293 (18%)

Query: 274 EPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGE-----RINSSWEKETPG 328
           E +I E  ++++   E +G  + K   +  K +   D  ++ E     +    W++E   
Sbjct: 510 EEKIWEQEEKIRDQEEMWG--QEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQE--- 564

Query: 329 ERSHSRVDSQSDK---------KLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQ 379
           ER   +   Q  K         + ER  ER + +  +E   +++EE+  +Q+ K   +++
Sbjct: 565 ERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEE 624

Query: 380 DHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSN 439
             W + E                  K   +E + WE  ++        ++  R P     
Sbjct: 625 KMWEQEE------------------KMQEQEEKMWEQEEKMWEQEEKMWEQQRLP----- 661

Query: 440 SRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESKEENRHIRNEKRVPTEHLQK 499
                  + KE      WE+  ++ +    E + K  ++ K E +    EK+   +   +
Sbjct: 662 -------EQKE----KLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMR 710

Query: 500 TNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAMKAESGPNETKNK 552
             +  ++    ++++ E   ++ E +     +  + +E   + E    E + K
Sbjct: 711 EEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEK 763



 Score = 32.3 bits (72), Expect = 4.7
 Identities = 27/106 (25%), Positives = 55/106 (51%), Gaps = 12/106 (11%)

Query: 1117 DRLFEQQ-LPDMKKKLWKFVDDQLDYLFAKLKKILVCDSKSFGRDSDEGKLEKTSKQNAQ 1175
            ++++EQQ LP+ K+KLW+    Q      + +K+   + K + ++  E   +KT +Q  +
Sbjct: 652  EKMWEQQRLPEQKEKLWEHEKMQ------EQEKMQEQEEKIWEQEKME---KKTQEQEKK 702

Query: 1176 YSNSQKRSVDNSNRELLKEKLSKSEDPVHYKSLVGCKKSEENYQDQ 1221
              + +K   + S RE  +EK  + E+ +  +     ++ EE  Q+Q
Sbjct: 703  TWDQEKMREEESMRE--REKKMREEEEMMREQEEKMQEQEEKMQEQ 746


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score = 56.2 bits (134), Expect = 3e-07
 Identities = 246/1253 (19%), Positives = 479/1253 (38%), Gaps = 186/1253 (14%)

Query: 194  SLPN-LEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDIRH 252
            SLP+ +E+  K   DK    H+ TS +    + V    H +       E+  + + D+  
Sbjct: 751  SLPSEVERLRKEIQDKSEELHIITSEKDKLFSEV---VHKESRVQGLLEEIGKTKDDLAT 807

Query: 253  SQFN-RGTERVRKDLSTGCGDGEPR---ILEASQRLQGHPEKYGKGEPKTESKSSKFKSN 308
            +Q N + T++  ++  T   D E +   +LE ++R+        K   K +S     K+ 
Sbjct: 808  TQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKT- 866

Query: 309  SDSDYKG-----------ERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKE 357
             +  YK            ER+N   + +   E   S + +   +K     +  Q +   +
Sbjct: 867  -ELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVK 925

Query: 358  VKSQDKEERKVDQKPKSVVKD----------------QDHWRRSERASLPHSKNEITFSH 401
              +Q+K++ K  Q+   + +D                Q+  R +  +   H +   T   
Sbjct: 926  TLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKS 985

Query: 402  N-----SSKYHLEERRG-WEDCKRDKSVNSHSFQDGRCPSS------------LSNSRTH 443
                  S   H+EE  G  +D  + K V     QD    ++            +   R  
Sbjct: 986  KISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKI 1045

Query: 444  KNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQ--ESKEENRHIRNEKRVPTE------ 495
             ++  ++ +     E+   + E+ +T+ K   E   E++EE R + +E +   E      
Sbjct: 1046 FSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEK 1105

Query: 496  --------HLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAMKAESGPN 547
                     L +T     +    LK++++   +K + L N   E ++ ++   + E+  N
Sbjct: 1106 NHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKN 1165

Query: 548  ETKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITDIPKSSGVC-DSESSMQVKTVAYV 606
            E KNK+L L  M+   L L+         +N  ++  I K   V  + + S + +     
Sbjct: 1166 ELKNKELTLEHMETERLELAQK-----LNENYEEVKSITKERKVLKELQKSFETE----- 1215

Query: 607  PSISEHILGEAAVSEHTMGETKSTLLEPKVALL----AVTEPRIGISETNKEDENSLLVR 662
                +H+ G     E T  +TK  L    + L      + E R  +SE   +  N+  + 
Sbjct: 1216 ---RDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLE 1272

Query: 663  SVDNTMHCEEPICGTETS-FPSPMEIQQTESLFPSTGM---KQTINNGRAAAPVVMDVLQ 718
                 +  E P+   E    P+  E+ +T+       +   + T  +    A + M+ L+
Sbjct: 1273 KSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLR 1332

Query: 719  -TDVSQNFGLELDTKRNDNSDYCGISEGMEMK-VALSTTVSETTESILQPSIEEADILPI 776
              +  Q    E+ +   +  +   I E +E+K   L   + ET   I +   ++   L  
Sbjct: 1333 LNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLN- 1391

Query: 777  MLSEDNNPKFEPSVIVTPLVESKSCHLEPCLPKETLDSSLQQTELMDHRMATGETNSVYH 836
            M  +DN    E + IV+ + + K        PK   DS+L + E+    +   +     H
Sbjct: 1392 MKEKDN----ETTKIVSEMEQFK--------PK---DSALLRIEI--EMLGLSKRLQESH 1434

Query: 837  DDDNSVL--SIDLNHLRPIPEAIS-PLNSPVRP-VAKVLRNESPPQVPVYNNSHKDVFLP 892
            D+  SV     DL  L+ + ++ S  L   ++  VAK L  E   +V             
Sbjct: 1435 DEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKV------------- 1481

Query: 893  NSAHSTSKSQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFE 952
              AH   K Q +    N+  +  S+K TE  T +   L+ + +       E  + +E F 
Sbjct: 1482 --AHCCLKEQEE--TINELRVNLSEKETEISTIQKQ-LEAINDKLQNKIQEIYEKEEQFN 1536

Query: 953  KNSKRRVSADVRKSKTIP--RRGKSTVCLDKDSRKTHV--RIHQTNNKWNKRPDKSSRSS 1008
                  V   V + K     R+ K +     +S+   +  R+ ++  +      +     
Sbjct: 1537 IKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMK 1596

Query: 1009 KTEKKDKVMSTSSLEKIVPIIA-VPSSEQEIMHMLRMIRKHVRKNYM----KFKAKFSLI 1063
            + ++  ++      E    I+A +  S+++    L+M   +  +  M      K +F   
Sbjct: 1597 RVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQ 1656

Query: 1064 QFH-RIIESAILSFTSLIKHLNLHKISKSVTTLQKNLCDIIESKLKQVKKNGIVDRLFEQ 1122
            + +   IE+  +  T ++ H NL ++ +SVT  + +L  + E+   +V+++ + + L E 
Sbjct: 1657 KLNLENIETENIRLTQIL-HENLEEM-RSVTKERDDLRSVEET--LKVERDQLKENLRET 1712

Query: 1123 QLPDMKKKLWKFVDDQLDYLFAKLKKILVCDSKSFGRDSDEGKLEKTSKQNAQYSNSQKR 1182
               D++K+      ++L  +   LK+      K  G  S     EKT+    + SN QK 
Sbjct: 1713 ITRDLEKQ------EELKIVHMHLKEHQETIDKLRGIVS-----EKTN----EISNMQK- 1756

Query: 1183 SVDNSNRELLKEKLSKSED----PVHYKSLVGCKKSEENYQDQNNSSINTVKHDIKKNFN 1238
             +++SN  L  + L   E+     +H K              +    ++ ++ D++ +  
Sbjct: 1757 DLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNA 1816

Query: 1239 ICFDNIKNSQSEERSLEVHCPSTPKSEKNEGSSIEDAQTSQHATLKPERSFEILTEQQAS 1298
               + I+  ++ E  L      T K + NE       + S+   LK +   + LT  +  
Sbjct: 1817 KLQEKIQELKANEHQL-----ITLKKDVNE----TQKKVSEMEQLKKQIKDQSLTLSKLE 1867

Query: 1299 SLTFNLVSDAQMG-EIFKSLLQGSDLLDSSVNCTEKSEWELKTPEKQLLETLK 1350
                NL        E  KS+++  D L        + E  LK    QL E+L+
Sbjct: 1868 IENLNLAQKLHENLEEMKSVMKERDNL-------RRVEETLKLERDQLKESLQ 1913



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 191/1053 (18%), Positives = 388/1053 (36%), Gaps = 138/1053 (13%)

Query: 87   MKELMKKFKEIQTQNFSLINENQSLKKNISALIKTARVEINRKDEEISNLHQRLSEFPHF 146
            +K+L +  +  + Q  S I++  ++  +    ++ A   + +  E I+ L  ++SE    
Sbjct: 934  LKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVS- 992

Query: 147  RNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHRAKSDVSKDVHHSTSLPNLEKEGKPHS 206
            RN H    T +T    + + +   +D     + +    ++ DV  +  +    K      
Sbjct: 993  RNLHMEENTGET--KDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQ 1050

Query: 207  DKRSTSHLPTSV--EKHCTNGVWSRSHYQVGEGSSN----EDSRRGRKDIRHSQFNRGTE 260
            +K     +  SV  EK         +     E         D  + +++I   + N   +
Sbjct: 1051 EKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIK 1110

Query: 261  RVRKDLSTGC---GDGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGER 317
            +   +LS  C    + E ++ E SQ+LQ             E +        +     ++
Sbjct: 1111 K-EGELSRTCDRLAEVEEKLKEKSQQLQ-------------EKQQQLLNVQEEMSEMQKK 1156

Query: 318  INSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVK 377
            IN     +   +     ++    ++LE   + ++N   +EVKS  KE + + +  KS   
Sbjct: 1157 INEIENLKNELKNKELTLEHMETERLELAQKLNENY--EEVKSITKERKVLKELQKSFET 1214

Query: 378  DQDHWR---RSERASLPHSKNEITFSHNSSKYH---LEERRGWEDCKRDKSVN------S 425
            ++DH R   R   A+   +K E+  +H   K H   ++E R     K  + +N      S
Sbjct: 1215 ERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKS 1274

Query: 426  HSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWEN-TPLKAERHRTEDK------------ 472
            H+      P          N+  KEV    +  N   L  E+  T+D             
Sbjct: 1275 HTKLQEEIPVLHEEQELLPNV--KEVSETQETMNELELLTEQSTTKDSTTLARIEMERLR 1332

Query: 473  -RKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSE 531
              ++ QES+EE + +  E+    ++L KT KE  +   D  K++  +T         + E
Sbjct: 1333 LNEKFQESQEEIKSLTKER----DNL-KTIKEALEVKHDQLKEHIRETLA------KIQE 1381

Query: 532  GADNKELAMKAESGPNET----------KNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHK 581
                +E ++  +   NET          K KD  L  ++   L LS  K+   S D    
Sbjct: 1382 SQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLS--KRLQESHDEMKS 1439

Query: 582  IT----DIPKSSGVCDSESSMQVKTVAYVPSISEHILGEAAVSEHTMGETKSTLLEPKVA 637
            +     D+ +   V  SES    + +  + +       E  V+   + E + T+ E +V 
Sbjct: 1440 VAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVN 1499

Query: 638  LLAVTEPRIGISETNKEDENSLLVRSVDNTMHCEEPICGTETSFPSPMEIQQTESLFPST 697
             L+  E  I   +   E  N  L   +      EE              I+Q   +    
Sbjct: 1500 -LSEKETEISTIQKQLEAINDKLQNKIQEIYEKEE-----------QFNIKQISEVQEKV 1547

Query: 698  GMKQTINNGRAAAPVVMDVLQTDVSQNFGLELDTKRNDNSD--YCGISEGMEMKVALSTT 755
               +     R A    +  +++ +     LEL  +  ++ +     I E  EMK      
Sbjct: 1548 NELKQFKEHRKAKDSALQSIESKM-----LELTNRLQESQEEIQIMIKEKEEMKRVQEAL 1602

Query: 756  VSETTESILQPSIEEADILPIMLSEDNNPKFEPSVIVTPLVESKSCHLEPCLPK-ETLDS 814
              E  +  L+ + +E  +  +  S++   +F     V    + K C +E    + ET   
Sbjct: 1603 QIERDQ--LKENTKEI-VAKMKESQEKEYQFLKMTAVNE-TQEKMCEIEHLKEQFETQKL 1658

Query: 815  SLQQTELMDHRMATGETNSVYHDDDNSVLSI--DLNHLRPIPEAISPLNSPVRP------ 866
            +L+  E  + R+       + H++   + S+  + + LR + E +      ++       
Sbjct: 1659 NLENIETENIRL-----TQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETI 1713

Query: 867  VAKVLRNESPPQVPVYNNSHKDV------FLPNSAHSTSKSQSDLNKENQKPIYKSDKCT 920
               + + E    V ++   H++        +    +  S  Q DL   N     +  K  
Sbjct: 1714 TRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQ 1773

Query: 921  EADTCKNSPLDELEE------GEIRSDSETSKPQESFEKNSKRRVSADVRKSKTIPRRGK 974
            E     +  L E +E      G +   ++     +   +NS  ++   +++ K       
Sbjct: 1774 EELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKA---NEH 1830

Query: 975  STVCLDKDSRKTHVRIHQTNNKWNKRPDKSSRSSKTEKKDKVMST---SSLEKIVPIIAV 1031
              + L KD  +T  ++ +      +  D+S   SK E ++  ++     +LE++  ++  
Sbjct: 1831 QLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKE 1890

Query: 1032 PSSEQEIMHMLRMIRKHVRKNYMKFKAKFSLIQ 1064
              + + +   L++ R  ++++  + KA+   IQ
Sbjct: 1891 RDNLRRVEETLKLERDQLKESLQETKARDLEIQ 1923



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 125/645 (19%), Positives = 243/645 (37%), Gaps = 116/645 (17%)

Query: 37   DSAVSDSASKSCVPSRNCLDLYEEI--LTEEGTAKEATYNDLQVEYGKCQLQMKELMKKF 94
            DSA+    SK    +    +  EEI  + +E    +     LQ+E  + +   KE++ K 
Sbjct: 1561 DSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKM 1620

Query: 95   KEIQTQNF-----SLINENQSLKKNISALIKTARVE-INRKDEEISN------LHQRLSE 142
            KE Q + +     + +NE Q     I  L +    + +N ++ E  N      LH+ L E
Sbjct: 1621 KESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEE 1680

Query: 143  F---------------------PHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHRA 181
                                     + N +   T D  K ++LK    HL +  +T  + 
Sbjct: 1681 MRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKL 1740

Query: 182  KSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSNE 241
            +  VS+    +  + N++K+ +  +D      L    E          +H  + E     
Sbjct: 1741 RGIVSE---KTNEISNMQKDLEHSNDALKAQDLKIQEELRI-------AHMHLKEQQETI 1790

Query: 242  DSRRG------------RKDIRHS--------QFNRGTERVRKDLSTGCGDGEPRILEAS 281
            D  RG            +KD+ +S        Q  +  E     L     + + ++ E  
Sbjct: 1791 DKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEME 1850

Query: 282  Q---RLQGHPEKYGKGEPKTESKSSKFKSNSD--SDYKGERINSSWEKET-PGERSHSRV 335
            Q   +++       K E +  + + K   N +       ER N    +ET   ER   + 
Sbjct: 1851 QLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKE 1910

Query: 336  DSQS----DKKLERQSERSQNINRKEVKSQDKEERKVDQK-------PKSVVKDQDHWRR 384
              Q     D +++++ + ++ ++++  ++ DK   K+ +K        K + K +D  ++
Sbjct: 1911 SLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQK 1970

Query: 385  ------SERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLS 438
                   +   L   K ++  SH       + ++ +E   ++ S+ S    + +    L 
Sbjct: 1971 KIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFE--AQNLSMQSVRMDNFQLTKKLH 2028

Query: 439  NSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESKEENRHIRNEKRVPT---E 495
             S     I +KE D + + + + LK ER +     +       +N  ++ EKR+ +   +
Sbjct: 2029 ESLEEIRIVAKERDELRRIKES-LKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQ 2087

Query: 496  HLQKTNKETKKTTTDLKKQNEPKTDKGEVLD----NGVSEGADNKELAMKAESGPN---- 547
            HL ++ +E      +L K+     D  E L+    +   E    KEL+M+ ++  +    
Sbjct: 2088 HLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYL 2147

Query: 548  --------ETKNKDLKLSF---MKKLNLTLSPAKKQPVSQDNQHK 581
                     T N+   + F   MKKL   LS   K    ++ QH+
Sbjct: 2148 QTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTK---IKEEQHE 2189



 Score = 45.4 bits (106), Expect = 5e-04
 Identities = 108/591 (18%), Positives = 230/591 (38%), Gaps = 81/591 (13%)

Query: 65   EGTAKEATYNDLQVEYGKCQLQM------KELMKKFKEI----QTQNFSLINENQSLKKN 114
            E TA+     DL+  + K Q ++      +EL+   KE+    +T N   +   QS  K+
Sbjct: 1260 EKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKD 1319

Query: 115  ISALIKTARVEINRK--DEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLD 172
             + L   AR+E+ R   +E+     + +      R+N KT +    VK   LK    H+ 
Sbjct: 1320 STTL---ARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKE---HIR 1373

Query: 173  DC------SKTDHRAKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGV 226
            +       S++      ++ +  + +T + +  ++ KP    + ++ L   +E    +  
Sbjct: 1374 ETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKP----KDSALLRIEIEMLGLSKR 1429

Query: 227  WSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRGTERVRK---------------------- 264
               SH ++   +  +D  +  +++  S+ ++  E +++                      
Sbjct: 1430 LQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQ 1489

Query: 265  -----DLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERIN 319
                 +L     + E  I    ++L+   +K      +   K  +F     S+ + E++N
Sbjct: 1490 EETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQ-EKVN 1548

Query: 320  SSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQ 379
               + +   +   S + S   K LE  +   ++    ++  ++KEE K  Q+   + +DQ
Sbjct: 1549 ELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQ 1608

Query: 380  --DHWRRSERASLPHSKNEITFSHNSSKYHLEERR-GWEDCKRDKSVNSHSFQDGRCPSS 436
              ++ +          + E  F   ++    +E+    E  K        + ++    + 
Sbjct: 1609 LKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENI 1668

Query: 437  LSNSRTHKNID-----SKEVDAMHQWENTPLKAERHRTEDKRK----REQESKEENRHIR 487
                  H+N++     +KE D +   E T LK ER + ++  +    R+ E +EE + + 
Sbjct: 1669 RLTQILHENLEEMRSVTKERDDLRSVEET-LKVERDQLKENLRETITRDLEKQEELKIVH 1727

Query: 488  NEKRVPTEHLQKTN---KETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAMKAES 544
               +   E + K      E     ++++K  E   D  +  D  + E      + +K + 
Sbjct: 1728 MHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQ 1787

Query: 545  GPNE-----TKNKDLKLSFMKKLNLTLSPAKKQPVSQD---NQHKITDIPK 587
               +        K  KLS M+K +L  S AK Q   Q+   N+H++  + K
Sbjct: 1788 ETIDKLRGIVSEKTDKLSNMQK-DLENSNAKLQEKIQELKANEHQLITLKK 1837


>gi|154146223 splicing factor, arginine/serine-rich 130 [Homo
           sapiens]
          Length = 805

 Score = 56.2 bits (134), Expect = 3e-07
 Identities = 79/381 (20%), Positives = 149/381 (39%), Gaps = 33/381 (8%)

Query: 128 RKDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHRAKSDVSK 187
           RK++E   LH +  E    +   +  +  +    K+  S S  L +  + D    ++  +
Sbjct: 428 RKEKEQQLLHDKQME-EEKQQTERVTKEMNEFIHKEQNSLS--LLEAREADGDVVNEKKR 484

Query: 188 DVHHSTSL-------PNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSN 240
             + +TS+          EK+G+  S   S+    ++     T+   S S Y    GSS 
Sbjct: 485 TPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSR 544

Query: 241 EDSRRG--RKDIRHSQFNRGTERVRKDLSTGCGDG----------EPRILEASQRLQGHP 288
             SR    ++  RHS+    T + R+  S                + R    S R     
Sbjct: 545 TSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIER 604

Query: 289 EKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDK----KLE 344
           E+     P  E + S+ +S      +  R  S   ++   +R +   +S   K    + E
Sbjct: 605 ERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQE 664

Query: 345 RQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSK--NEITFSHN 402
           R+ ERS++I++   K   + ER+ D++ +   +++  ++ S +      K  +E TFS +
Sbjct: 665 RKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRS 724

Query: 403 SS-KYHLEERRGWEDCKRD--KSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWEN 459
            S    +      +D K+   K    HS  D    SS  +  + K  + K     H    
Sbjct: 725 GSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSK--EKKAKKPKHSRSR 782

Query: 460 TPLKAERHRTEDKRKREQESK 480
           +  K++R   +  RK + +S+
Sbjct: 783 SVEKSQRSGKKASRKHKSKSR 803



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 67/311 (21%), Positives = 120/311 (38%), Gaps = 46/311 (14%)

Query: 287 HPEKYGKGEPKTESKSS-KFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLER 345
           H EK  +G  ++ S SS    SNS +      ++SS    + G    S   S   +K   
Sbjct: 499 HKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRH 558

Query: 346 QSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSK 405
              RS  I  +  +S+    R   +  ++ VK +D  RRS R S+   +         ++
Sbjct: 559 SRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDR-RRSNRNSIERERRR-------NR 610

Query: 406 YHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAE 465
               ERR      RD+  N          +S S SR  + ID +  +         L   
Sbjct: 611 SPSRERRRSRSRSRDRRTNR---------ASRSRSRDRRKIDDQRGN---------LSGN 652

Query: 466 RHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVL 525
            H      K + E+KE+ R          E  +  +K+ KK   + +++ + + +K +  
Sbjct: 653 SH------KHKGEAKEQER--------KKERSRSIDKDRKKKDKEREREQDKRKEKQKRE 698

Query: 526 DNGVSEGADNKELAMKAESGPNETKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITDI 585
           +      + +  L  K ES    +++  + +  ++  + +   +KK       +H  +D 
Sbjct: 699 EKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIR--HDSRQDSKKSTTKDSKKHSGSD- 755

Query: 586 PKSSGVCDSES 596
             SSG   SES
Sbjct: 756 --SSGRSSSES 764



 Score = 40.4 bits (93), Expect = 0.017
 Identities = 48/250 (19%), Positives = 98/250 (39%), Gaps = 33/250 (13%)

Query: 291 YGKGEPKTESKSSKFKSNSDSDYKG------ERINSSWEKETPGERSHSRVDSQSDKKLE 344
           YG G+ + E +S +   +SD+D +       ++  + W KE   +  H       DK++E
Sbjct: 391 YGSGDSEDE-RSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLH-------DKQME 442

Query: 345 RQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSS 404
            + ++++ + ++  +   KE+  +        ++ D    +E+   P   NE T      
Sbjct: 443 EEKQQTERVTKEMNEFIHKEQNSLSLLE---AREADGDVVNEKKRTP---NETTSVLEPK 496

Query: 405 KYHLEERR-----------GWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDA 453
           K H E+ +           G        S  S +       SS  +SRT     S +   
Sbjct: 497 KEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKK 556

Query: 454 MHQWENTP-LKAERHRTED-KRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDL 511
            H    +P +KA R R+    R+ + ES      IR+ +R     +++  +  +  + + 
Sbjct: 557 RHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRER 616

Query: 512 KKQNEPKTDK 521
           ++      D+
Sbjct: 617 RRSRSRSRDR 626


>gi|154146193 splicing factor, arginine/serine-rich 130 [Homo
           sapiens]
          Length = 805

 Score = 56.2 bits (134), Expect = 3e-07
 Identities = 79/381 (20%), Positives = 149/381 (39%), Gaps = 33/381 (8%)

Query: 128 RKDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHRAKSDVSK 187
           RK++E   LH +  E    +   +  +  +    K+  S S  L +  + D    ++  +
Sbjct: 428 RKEKEQQLLHDKQME-EEKQQTERVTKEMNEFIHKEQNSLS--LLEAREADGDVVNEKKR 484

Query: 188 DVHHSTSL-------PNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSN 240
             + +TS+          EK+G+  S   S+    ++     T+   S S Y    GSS 
Sbjct: 485 TPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSR 544

Query: 241 EDSRRG--RKDIRHSQFNRGTERVRKDLSTGCGDG----------EPRILEASQRLQGHP 288
             SR    ++  RHS+    T + R+  S                + R    S R     
Sbjct: 545 TSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIER 604

Query: 289 EKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDK----KLE 344
           E+     P  E + S+ +S      +  R  S   ++   +R +   +S   K    + E
Sbjct: 605 ERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQE 664

Query: 345 RQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSK--NEITFSHN 402
           R+ ERS++I++   K   + ER+ D++ +   +++  ++ S +      K  +E TFS +
Sbjct: 665 RKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRS 724

Query: 403 SS-KYHLEERRGWEDCKRD--KSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWEN 459
            S    +      +D K+   K    HS  D    SS  +  + K  + K     H    
Sbjct: 725 GSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSK--EKKAKKPKHSRSR 782

Query: 460 TPLKAERHRTEDKRKREQESK 480
           +  K++R   +  RK + +S+
Sbjct: 783 SVEKSQRSGKKASRKHKSKSR 803



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 67/311 (21%), Positives = 120/311 (38%), Gaps = 46/311 (14%)

Query: 287 HPEKYGKGEPKTESKSS-KFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLER 345
           H EK  +G  ++ S SS    SNS +      ++SS    + G    S   S   +K   
Sbjct: 499 HKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRH 558

Query: 346 QSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSK 405
              RS  I  +  +S+    R   +  ++ VK +D  RRS R S+   +         ++
Sbjct: 559 SRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDR-RRSNRNSIERERRR-------NR 610

Query: 406 YHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAE 465
               ERR      RD+  N          +S S SR  + ID +  +         L   
Sbjct: 611 SPSRERRRSRSRSRDRRTNR---------ASRSRSRDRRKIDDQRGN---------LSGN 652

Query: 466 RHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVL 525
            H      K + E+KE+ R          E  +  +K+ KK   + +++ + + +K +  
Sbjct: 653 SH------KHKGEAKEQER--------KKERSRSIDKDRKKKDKEREREQDKRKEKQKRE 698

Query: 526 DNGVSEGADNKELAMKAESGPNETKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITDI 585
           +      + +  L  K ES    +++  + +  ++  + +   +KK       +H  +D 
Sbjct: 699 EKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIR--HDSRQDSKKSTTKDSKKHSGSD- 755

Query: 586 PKSSGVCDSES 596
             SSG   SES
Sbjct: 756 --SSGRSSSES 764



 Score = 40.4 bits (93), Expect = 0.017
 Identities = 48/250 (19%), Positives = 98/250 (39%), Gaps = 33/250 (13%)

Query: 291 YGKGEPKTESKSSKFKSNSDSDYKG------ERINSSWEKETPGERSHSRVDSQSDKKLE 344
           YG G+ + E +S +   +SD+D +       ++  + W KE   +  H       DK++E
Sbjct: 391 YGSGDSEDE-RSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLH-------DKQME 442

Query: 345 RQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSS 404
            + ++++ + ++  +   KE+  +        ++ D    +E+   P   NE T      
Sbjct: 443 EEKQQTERVTKEMNEFIHKEQNSLSLLE---AREADGDVVNEKKRTP---NETTSVLEPK 496

Query: 405 KYHLEERR-----------GWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDA 453
           K H E+ +           G        S  S +       SS  +SRT     S +   
Sbjct: 497 KEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKK 556

Query: 454 MHQWENTP-LKAERHRTED-KRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDL 511
            H    +P +KA R R+    R+ + ES      IR+ +R     +++  +  +  + + 
Sbjct: 557 RHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRER 616

Query: 512 KKQNEPKTDK 521
           ++      D+
Sbjct: 617 RRSRSRSRDR 626


>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
          Length = 1564

 Score = 55.5 bits (132), Expect = 5e-07
 Identities = 114/554 (20%), Positives = 216/554 (38%), Gaps = 66/554 (11%)

Query: 69   KEATYNDLQVEYGKCQLQMKELMKKFKEIQTQNFSLINENQSLKKNISALIKTARVEINR 128
            KE TY +    YG+       L ++    + +N S  NE++S  +N        RV    
Sbjct: 518  KEDTYPEESRSYGR-----NHLREESSRTEIRNESR-NESRSEIRNDRMGRSRGRVP--- 568

Query: 129  KDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHRAKS-DVSK 187
               E+     R S      ++   +   D+ +T+   S  P  D   + D+R ++ D S 
Sbjct: 569  ---ELPEKGSRGSRGSQIDSHSSNSNYHDSWETR---SSYPERDRYPERDNRDQARDSSF 622

Query: 188  DVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRRGR 247
            +  H           +   D R     P+S  +H         + ++      E+ R  R
Sbjct: 623  ERRHGE---------RDRRDNRERDQRPSSPIRH------QGRNDELERDERREERRVDR 667

Query: 248  KDIRHSQFNRGTERVR-KDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFK 306
             D R  +  R  +R R +D          R  E  +  +   E+  + E + E +  + +
Sbjct: 668  VDDRRDERARERDRERERDRERERERERERDREREKERELERERAREREREREKERDR-E 726

Query: 307  SNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKSQDKE-E 365
             + D D+  ER     E++   ER   R + + +++ ER+ ER +   R+  + +DKE E
Sbjct: 727  RDRDRDHDRERERER-ERDREKEREREREERERERERERERERERERERERARERDKERE 785

Query: 366  RKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLE---ERRGWEDCKRDKS 422
            R+ D + K   +D    +R E     + ++      +  +Y  E     R     +R+ S
Sbjct: 786  RQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHS 845

Query: 423  VNSHSFQDG-------RCPSSLSNSRTHKNIDSKEV--DAMHQWENTPLKAERHRTEDKR 473
             +S ++  G       R  S +   +  +++    +  D   +W+    K ER +   +R
Sbjct: 846  PDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPER-KESSRR 904

Query: 474  KREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGA 533
              EQE KE+   + +++R  TE L+ +    +      + ++   +D+    +N      
Sbjct: 905  YEEQELKEKVSSV-DKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHD-ENKKKAKI 962

Query: 534  DNKELAMKAES------GPNETKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITDIPK 587
              K +  K E       G  ET ++D ++   KK     S  KK+  S+ +         
Sbjct: 963  QKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGD--------- 1013

Query: 588  SSGVCDSESSMQVK 601
             S + D E++ Q K
Sbjct: 1014 -SDISDEEAAQQSK 1026



 Score = 51.6 bits (122), Expect = 8e-06
 Identities = 102/504 (20%), Positives = 188/504 (37%), Gaps = 84/504 (16%)

Query: 59  EEILTEEGTAKEATYNDLQVEY-GKCQLQMKELMKKFKEIQTQNFSLINENQSLKKNISA 117
           EE +  E    ++   D+  +Y  +  L+MK      ++IQ +   L  EN   ++ I  
Sbjct: 139 EENVEWETNRDDSDNGDINYDYVHELSLEMKR-----QKIQRELMKLEQENMEKREEI-- 191

Query: 118 LIKTARVEINRKDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKT 177
                   I +K+     +  +LS  P  R + K+ +          +  SP     SK 
Sbjct: 192 --------IIKKEVSPEVVRSKLSPSPSLRKSSKSPK----------RKSSPKSSSASKK 233

Query: 178 DHRAKSDVSKDVHHSTSLPNLEKEGKPHSDKRS---TSHLPTSVEKHCTNGVWSRSHYQV 234
           D +  +        S+ L + ++  K +  K+    T   P  + +    G   +  Y+V
Sbjct: 234 DRKTSAV-------SSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKV 286

Query: 235 GEGSSNEDSRRGRKDIRHSQFNRGTERVRKDLSTG-CGDGEPRIL--------EASQRLQ 285
            +    E+  R  KD R   F R  E+  K  ST   G     I         ++   +Q
Sbjct: 287 KDRI--EEKTRDGKD-RGRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQ 343

Query: 286 GH---PEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETP----------GERSH 332
            H   P +     P  +   +     S S Y    ++S   K++P          G   H
Sbjct: 344 RHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDH 403

Query: 333 SRVDSQSDKKLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPH 392
            R     D++ ER   R     +++ +   +EER+ +Q   S    +DH  R +R     
Sbjct: 404 ERTSQSHDRRHER---REDTRGKRDREKDSREEREYEQDQSS---SRDH--RDDREP-RD 454

Query: 393 SKNEITFSHNSSKYHLEERRGWEDCK--RDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKE 450
            ++         +  L + R   D +  RD S ++   +D R   S  ++  +++ + ++
Sbjct: 455 GRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRD 514

Query: 451 V--------DAMHQWENTPLKAERHRTEDKRKREQESKEE---NRHIRNEKRVPTEHLQK 499
                    +    +    L+ E  RTE + +   ES+ E   +R  R+  RVP E  +K
Sbjct: 515 THRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVP-ELPEK 573

Query: 500 TNKETKKTTTDLKKQNEPKTDKGE 523
            ++ ++ +  D    N    D  E
Sbjct: 574 GSRGSRGSQIDSHSSNSNYHDSWE 597



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 71/323 (21%), Positives = 120/323 (37%), Gaps = 46/323 (14%)

Query: 186  SKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGS----SNE 241
            ++D H       +EK   PH       H     +K  ++   +RS+     G     SN+
Sbjct: 1153 NEDSHRKCHRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSND 1212

Query: 242  DSRR------GRKDIRHSQFNRGTERVRKDLSTG--------CGDGEPRILEASQRLQGH 287
             + R      GRK + HS  +R  E+ +    TG           GEP    +S R    
Sbjct: 1213 SAHRSGDDQSGRKRVLHSG-SRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSR 1271

Query: 288  PEKYGKGEPKTESKSSKFKSNSDS-DYKGERINSSWEKETPGERSHSRV---DSQSDKKL 343
                 +  P+++ +      + DS D   ER     ++E   ER  +R    D  +DK  
Sbjct: 1272 SHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDW 1331

Query: 344  ERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQ-DHWRRSERASLPHSKNEITFSHN 402
             R  +R +   R+  + +DK  R +D++ + ++ D  +  R  +R     S    +    
Sbjct: 1332 PRNRDRDRLRERERERERDK-RRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRC 1390

Query: 403  SSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPL 462
             +K   E  R  E   RD               +L   R  K++ S     +  +E T  
Sbjct: 1391 EAKLEGEHERDLESTSRDS-------------LALDKERMDKDLGS-----VQGFEET-- 1430

Query: 463  KAERHRTEDKRKREQESKEENRH 485
              +  RTE     + ESK ++ H
Sbjct: 1431 -NKSERTESLEAGDDESKLDDAH 1452



 Score = 32.3 bits (72), Expect = 4.7
 Identities = 44/210 (20%), Positives = 79/210 (37%), Gaps = 18/210 (8%)

Query: 200  KEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRGT 259
            K G+P    RSTS        H +      S  QV   S + DSR   ++    + +R  
Sbjct: 1255 KRGEP---SRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRER 1311

Query: 260  ERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGER-I 318
            ER R+D      D +          +  P    +   +   +  +     D D + ER I
Sbjct: 1312 ERERRDTRQREWDRDAD--------KDWPRNRDRDRLRERERERERDKRRDLDRERERLI 1363

Query: 319  NSSWEKETPGERSHSRVDSQSDK------KLERQSERSQNINRKEVKSQDKEERKVDQKP 372
            + S E++   +R  +   SQ +       KLE + ER      ++  + DKE    D   
Sbjct: 1364 SDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEHERDLESTSRDSLALDKERMDKDLGS 1423

Query: 373  KSVVKDQDHWRRSERASLPHSKNEITFSHN 402
                ++ +   R+E       ++++  +H+
Sbjct: 1424 VQGFEETNKSERTESLEAGDDESKLDDAHS 1453


>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 750

 Score = 55.1 bits (131), Expect = 7e-07
 Identities = 109/587 (18%), Positives = 230/587 (39%), Gaps = 84/587 (14%)

Query: 58  YEEILTEEGTAKEATYNDLQVEYGKCQLQMKELMKKFKEIQTQNFSLINENQS------- 110
           ++E L  E  A+  T   L  +  + Q+ +       K+++ +   LI+           
Sbjct: 117 HQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGE 176

Query: 111 LKKNISALIKTARVEINRKDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPH 170
           L++ +SA + T + + +R  EE++     LS    +RN         T+  ++LK ++  
Sbjct: 177 LEQALSA-VATQKKKADRYIEELTKERDALS-LELYRN---------TITDEELKEKNAK 225

Query: 171 LDDCSKTDHRAKSDVSKDVHH--------STSLPNLEKEGKP-HSDKRSTS---HLPTSV 218
           L +  +     KS++  +V             LP  + + +  H  K   S    L   V
Sbjct: 226 LQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQV 285

Query: 219 EKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRIL 278
           E+   N +W+R + Q       ++ +  R++ +  ++    E++++         E +I 
Sbjct: 286 EE---NELWNRLNQQ-------QEEKMWRQEEKIQEWE---EKIQEQ--------EEKIR 324

Query: 279 EASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGE-----RINSSWEKETPGERSHS 333
           E  ++++   EK  + E     K  K +   +  ++ E     +    WEKE    R   
Sbjct: 325 EQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEE 384

Query: 334 RVDSQSDK--KLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLP 391
            +  + +K  +LE +    + I  +E K Q  EE K+ ++ K   ++   WR+ E+    
Sbjct: 385 MMWEKEEKIRELEEKMHEQEKIREQEEKRQ--EEEKIREQEKRQEQEAKMWRQEEKIREQ 442

Query: 392 HSK---NEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDS 448
             K    E        K H +E+   E+ ++++       Q+ +        R  + +  
Sbjct: 443 EEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWR--QEEKIHEQEEIWRQKEKMHE 500

Query: 449 KEVDAMHQWENTPLKAERHRTEDKRKREQESK----------------EENRHIRNEKRV 492
           +E     Q E    + E+ R ++++ REQE K                EE +    EK  
Sbjct: 501 QEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIW 560

Query: 493 PTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAMKAESGPNETKNK 552
             E  Q+   +  +    +++Q E    + E +     +  + +E   K E    E + K
Sbjct: 561 EEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEK 620

Query: 553 DLKLSFMKKLNLTLSPAKKQPVSQDNQHKITDIPKSSGVCDSESSMQ 599
            ++    K         +++ ++Q+ + K+ +  +   +C+ E  MQ
Sbjct: 621 -IQEQEEKIREQEEKIREQEEMTQEQEEKMGE--QEEKMCEQEEKMQ 664



 Score = 39.7 bits (91), Expect = 0.030
 Identities = 28/148 (18%), Positives = 59/148 (39%), Gaps = 8/148 (5%)

Query: 274 EPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHS 333
           E +  E   ++    EK  + E K   +  K +   +   + E+    W++E        
Sbjct: 562 EEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEK--RQEQEEKMWKQEEKIREQEE 619

Query: 334 RVDSQSDKKLERQS---ERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASL 390
           ++  Q +K  E++    E+ +    +E K  ++EE+  +Q+ K   +++  WR+ E+   
Sbjct: 620 KIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIRE 679

Query: 391 PHSK---NEITFSHNSSKYHLEERRGWE 415
              K    E            +E + WE
Sbjct: 680 QEKKIREQEEKIREQEEMMQEQEEKMWE 707



 Score = 38.5 bits (88), Expect = 0.066
 Identities = 31/152 (20%), Positives = 62/152 (40%), Gaps = 16/152 (10%)

Query: 274 EPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHS 333
           E +I E  ++ Q   EK  K E K   +  K +   +   + E      E+E   +    
Sbjct: 590 EEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEE--KIREQEEMTQEQEE 647

Query: 334 RVDSQSDK------KLERQSE----RSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWR 383
           ++  Q +K      K++ Q E    + + I  +E K +++EE+  +Q+     +++  W 
Sbjct: 648 KMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWE 707

Query: 384 RSERASLPHSKNEITFSHNSSKYHLEERRGWE 415
           + E+      + E        K   +E + WE
Sbjct: 708 QEEKM----CEQEEKMQEQEEKMRRQEEKMWE 735



 Score = 36.2 bits (82), Expect = 0.33
 Identities = 24/122 (19%), Positives = 54/122 (44%), Gaps = 8/122 (6%)

Query: 274 EPRILEASQRLQGHPEKYGKGEPKTESKSSKF-----KSNSDSDYKGERINSSWEKETPG 328
           E +I E  ++++   EK  + E  T+ +  K      K     +   E+  + W +E   
Sbjct: 618 EEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKI 677

Query: 329 ERSHSRVDSQSDKKLERQS---ERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRS 385
                ++  Q +K  E++    E+ + +  +E K  ++EE+  +Q+ K   +++  W + 
Sbjct: 678 REQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQE 737

Query: 386 ER 387
            R
Sbjct: 738 VR 739



 Score = 32.7 bits (73), Expect = 3.6
 Identities = 23/117 (19%), Positives = 48/117 (41%), Gaps = 6/117 (5%)

Query: 257 RGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGE 316
           R  E + ++     G+ E ++ E  +++Q   E   + E K   +  K +         E
Sbjct: 636 REQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQE------E 689

Query: 317 RINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKSQDKEERKVDQKPK 373
           +I    E     E      + +  ++ E+  E+ + + R+E K  ++E R   Q+ K
Sbjct: 690 KIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEK 746


>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
           protein 6 [Homo sapiens]
          Length = 724

 Score = 55.1 bits (131), Expect = 7e-07
 Identities = 67/341 (19%), Positives = 136/341 (39%), Gaps = 36/341 (10%)

Query: 274 EPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGE-----RINSSWEKETPG 328
           E +I E  +++Q   EK  + E K   +  K +   +  ++ E     +    WEKE   
Sbjct: 367 EEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKM 426

Query: 329 ERSHSRVDSQSDK--KLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSE 386
            R    +  + +K  +LE +    + I  +E K Q  EE K+ ++ K   ++   WR+ E
Sbjct: 427 RRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQ--EEEKIREQEKRQEQEAKMWRQEE 484

Query: 387 RASLPHSK---NEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTH 443
           +      K    E        K H +E+   E+ ++++       Q+ +        R  
Sbjct: 485 KIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWR--QEEKIREQEEIWRQK 542

Query: 444 KNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESK----EENRHIRNEK-RVPTEHLQ 498
           + I  +E     Q E    + E+   ++++ REQE K    EE    + EK R   E ++
Sbjct: 543 EKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIR 602

Query: 499 KTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAMKAESGPNETKNKDLKLSF 558
           +  + T++    + +Q E   ++ E +     +    +E   + E    E + K      
Sbjct: 603 EQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEK------ 656

Query: 559 MKKLNLTLSPAKKQPVSQDNQHKITDIPKSSGVCDSESSMQ 599
                      +++ + Q+ + K+ +  +   +C+ E  MQ
Sbjct: 657 ---------IREQEEMMQEQEEKMWE--QEEKMCEQEEKMQ 686



 Score = 48.5 bits (114), Expect = 6e-05
 Identities = 47/247 (19%), Positives = 105/247 (42%), Gaps = 31/247 (12%)

Query: 276 RILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRV 335
           ++L   Q+LQ   +  GK   + +S S+K ++  +        N  W          +R+
Sbjct: 316 KLLLPQQQLQAEADHLGK---ELQSVSAKLQAQVEE-------NELW----------NRL 355

Query: 336 DSQSDKKLERQSERSQN----INRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLP 391
           + Q ++K+ RQ E+ Q     I  +E K +++EE+  +Q+ K   +++  W + E+    
Sbjct: 356 NQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKM--- 412

Query: 392 HSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEV 451
             + E        K   +E   WE  ++ + +     +  +        +  + I  +E 
Sbjct: 413 -RRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQE- 470

Query: 452 DAMHQWENTPLKAERHRTEDKRKREQESK--EENRHIRNEKRVPTEHLQKTNKETKKTTT 509
               Q      + E+ R ++++ REQE K   +   I  ++++  E  ++  +E  +   
Sbjct: 471 KRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEE 530

Query: 510 DLKKQNE 516
            +++Q E
Sbjct: 531 KIREQEE 537



 Score = 36.6 bits (83), Expect = 0.25
 Identities = 32/149 (21%), Positives = 60/149 (40%), Gaps = 11/149 (7%)

Query: 241 EDSRRGRKDIRHSQFN-RGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTE 299
           E  R   + IR  +   R  E + ++     G+ E ++ E  +++Q   EK  + E K  
Sbjct: 585 EKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIR 644

Query: 300 SKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVK 359
            +  K +         E+I    E     E      + +  ++ E+  E+ + + R+E K
Sbjct: 645 EQEKKIREQE------EKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEK 698

Query: 360 SQDKEERKVDQKPKSVVKDQDHWRRSERA 388
             ++E R   Q+ K     Q+H    E A
Sbjct: 699 MWEQEVRLRQQEEKM----QEHQEHLEAA 723


>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
          Length = 2454

 Score = 55.1 bits (131), Expect = 7e-07
 Identities = 80/376 (21%), Positives = 149/376 (39%), Gaps = 35/376 (9%)

Query: 161  TKDLKSRSPHLDDCSKTDHRAKSDVSKDVHHSTSLPN---LEKEGKPHSDKRSTSHLPTS 217
            TK+++S S      S +D    S+ +K     TS      + KE K +S + ST      
Sbjct: 1108 TKEIQSGS------SSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQAD 1161

Query: 218  VEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKD----IRHSQF--NRGTERVRKDLSTGCG 271
            +    ++ +       +GEGSS+E   +   +      H+ F  + G E + K +     
Sbjct: 1162 ITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVD 1221

Query: 272  DGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPG-ER 330
            D +    +   R+    +K    E K    S +  S+ D   +G++      +E PG E 
Sbjct: 1222 DDDDDN-DPENRIA---KKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEE 1277

Query: 331  SHSRVDSQSDKKLERQSE---RSQNINRKEVKSQDK--EERKVDQKPKSVVKDQDHWRRS 385
            + ++V+S+SD   E   +   R + +  K   S  +  EE+K   K    VK ++  + S
Sbjct: 1278 AKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVS 1337

Query: 386  ERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKN 445
               S      E   S   S+   E+R       R +S      ++ +   S    +  + 
Sbjct: 1338 SEDSEDSDFQESGVSEEVSESEDEQR------PRTRSAKKAELEENQ--RSYKQKKKRRR 1389

Query: 446  IDSKEVDAMHQWENTPLKAERHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNKETK 505
            I  +E  +     N+  + E    E++ + E+E +EE     ++ + P +  +K  K  K
Sbjct: 1390 IKVQEDSSSENKSNS--EEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILK 1447

Query: 506  KTTTDLKKQNEPKTDK 521
                  + QN  K ++
Sbjct: 1448 DDKLRTETQNALKEEE 1463



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 122/635 (19%), Positives = 234/635 (36%), Gaps = 129/635 (20%)

Query: 95   KEIQTQNFSLINENQSLKKNISALIKTARVEINRKDEEISNLHQRLSEFPHFRNNHKTAR 154
            K+ QTQ+ S  N +  L+K I ++ K       +K   I N      +F    +   + +
Sbjct: 768  KKRQTQSESS-NYDSELEKEIKSMSKIGAARTTKK--RIPNT----KDFDSSEDEKHSKK 820

Query: 155  TFDTVKTKDLK-SRSPHLDDCSKTDHR-----AKSDVSKDV-------------HHSTSL 195
              D    K+LK S+    DD  +   R     A+  V KD                S S 
Sbjct: 821  GMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASAST 880

Query: 196  PNLEK-EGKPHS-----------DKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSNEDS 243
              ++K  GK  S            K  + HL T   K   +G+   +   + +  S+E S
Sbjct: 881  DGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETS 940

Query: 244  RRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTESKSS 303
               +K     Q  +GTE  +K       D + ++++  Q+ +            +   + 
Sbjct: 941  EDDKK-----QSKKGTEEKKKP-----SDFKKKVIKMEQQYES-----------SSDGTE 979

Query: 304  KFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKSQDK 363
            K     +  +  + I       T GE+   ++  ++ KK +  S+ ++    K       
Sbjct: 980  KLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSS 1039

Query: 364  EERKVDQKPKSVVKDQDHWRRSERASL---PHSKNEITFSHNSSKYHLEERRGWEDCKR- 419
            E++K         K+  + R  +R  L      K +   S ++ KY ++E    + C   
Sbjct: 1040 EDKKS--------KNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKE----DGCNSS 1087

Query: 420  DKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQES 479
            DK +     ++ R   +LS+ R  K I S    +          AE    ++K+K+++ S
Sbjct: 1088 DKRLKRIELRERR---NLSSKRNTKEIQSGSSSS---------DAEESSEDNKKKKQRTS 1135

Query: 480  KEENRHIRNEKR---VPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNK 536
             ++   I  EK+   + T   +K    T  +++D++  ++    +G   +  +    +N 
Sbjct: 1136 SKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENL 1195

Query: 537  ELA---------------------MKAESGPNETKNKDLKLSFMKKLNLTLS-------- 567
             L+                     +  +   N+ +N+  K   ++++   LS        
Sbjct: 1196 VLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSD 1255

Query: 568  ----PAKKQPVSQDNQHKITDIPKSSGVCDSES-SMQVKTVAYVPSISEHILGEAAVSEH 622
                  KK+   Q+ ++   +  K+    +S+S S + K   Y   +  H L    VS+ 
Sbjct: 1256 DEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKL---TVSDG 1312

Query: 623  TMGETKSTLLEPKVALLAVTEPRIGISETNKEDEN 657
              GE K T  +PK         R  +S  + ED +
Sbjct: 1313 ESGEEKKT--KPKEHKEVKGRNRRKVSSEDSEDSD 1345



 Score = 39.3 bits (90), Expect = 0.039
 Identities = 67/328 (20%), Positives = 128/328 (39%), Gaps = 60/328 (18%)

Query: 300 SKSSKFKSNSDSDY-----KGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNIN 354
           ++++   SNSD +      + ++++    K+     S S +D+    KL + S++S+ ++
Sbjct: 630 TETNPVTSNSDEECNETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPK-SKQSETVD 688

Query: 355 RKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGW 414
           +    + D +E     K  S        R S  +S     NEI  +H +  Y L+ + G 
Sbjct: 689 Q----NSDSDEMLAILKEVS--------RMSHSSSSDTDINEIHTNHKTL-YDLKTQAGK 735

Query: 415 EDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRK 474
           +D  + K  +S S  D                D+K+            K+ +     K+K
Sbjct: 736 DDKGKRKRKSSTSGSD---------------FDTKKG-----------KSAKSSIISKKK 769

Query: 475 REQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGAD 534
           R+ +S+  N     EK + +       + TKK   + K  +  + +K         +G D
Sbjct: 770 RQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHS------KKGMD 823

Query: 535 N---KELAMKAESGPNETKNKDLKLSF------MKKLNLTLSPAKKQPVSQDNQHKITDI 585
           N   K L    E   ++ + K  + +F      + K    +    + P  Q        +
Sbjct: 824 NQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGV 883

Query: 586 PKSSGVCDSESSMQVKTVAYVPSISEHI 613
            K SG   S +S++V+ VA     S+H+
Sbjct: 884 DKLSGKEQSFTSLEVRKVAETKEKSKHL 911



 Score = 37.7 bits (86), Expect = 0.11
 Identities = 93/445 (20%), Positives = 164/445 (36%), Gaps = 93/445 (20%)

Query: 265 DLSTGCGDG----EPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINS 320
           DL T C       E  + +  ++++   EK  K    T   S K K++S+ + + ++++ 
Sbjct: 237 DLVTACNSVFENLEQLLQQNKKKIKVDSEKSNKVYEHTSRFSPK-KTSSNCNGEEKKLDD 295

Query: 321 SWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVK--------SQDKEERKVDQKP 372
           S         S   V  +  KK ++  E + N+N   VK        S+     K+ Q  
Sbjct: 296 SCSGSVTYSYSALIVPKEMIKKAKKLIETTANMNSSYVKFLKQATDNSEISSATKLRQLK 355

Query: 373 --KSVVKD--------QDHWRRSERASLPHSKNEITFSHN--SSKYHLEERRGWEDCKRD 420
             KSV+ D        ++      RA    +K + T  H    +K+  + R+G + C  +
Sbjct: 356 AFKSVLADIKKAHLALEEDLNSEFRAMDAVNKEKNTKEHKVIDAKFETKARKGEKPCALE 415

Query: 421 KSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESK 480
           K                  S++   +  K+VD+ H  +N P       TE++R  +    
Sbjct: 416 KK---------------DISKSEAKLSRKQVDSEHMHQNVP-------TEEQRTNKSTGG 453

Query: 481 EENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAM 540
           E  +  R E         +   E   T+ DL        D   V  +   +  +N E AM
Sbjct: 454 EHKKSDRKE---------EPQYEPANTSEDL------DMDIVSVPSSVPEDIFENLETAM 498

Query: 541 KAESG-----------PNETKNKDLKLSFMKKLNL-TLSPAKKQPVSQDNQHKITDIPKS 588
           + +S              E ++  +KL+   K N   +       V+++   K+T +  S
Sbjct: 499 EVQSSVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTTAKVTKELYVKLTPVSLS 558

Query: 589 SGVCDSESSMQV-------KTVAYVPSISEHILG-EAAVSEHTMGETKSTLLE------- 633
           +         +V       K+    P + +  LG E + +EH +    S LLE       
Sbjct: 559 NSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVENEVSLLLEESDLRRS 618

Query: 634 PKVALLAVTEPRIGISETNKEDENS 658
           P+V    +  P    +ETN    NS
Sbjct: 619 PRVKTTPLRRP----TETNPVTSNS 639



 Score = 35.0 bits (79), Expect = 0.73
 Identities = 101/522 (19%), Positives = 177/522 (33%), Gaps = 86/522 (16%)

Query: 885  SHKDVFLPNSAHSTSKSQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSET 944
            S K   +      T    S+ + E +K I    K   A T K            R  +  
Sbjct: 759  SAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKK-----------RIPNTK 807

Query: 945  SKPQESFEKNSKRRVSADVRKSKTIPRRGKSTVCLDKDSRKTHVRIHQTNNK-------W 997
                   EK+SK+ +     K+    + G S     K  R+T      T +K        
Sbjct: 808  DFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELR 867

Query: 998  NKRPDKSSRSSKTEKKDKVMSTSSLEKIVPIIAVPSSEQEIMHMLRMIRKHVRKNYMKFK 1057
            ++ P K   S+ T+  DK+         + +  V  ++++  H+     K V+       
Sbjct: 868  DRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIA 927

Query: 1058 AKF------------SLIQFHRIIESAILSFTSLIKHLNLHKISKSVTTLQKNLCDIIE- 1104
             KF               Q  +  E          K + + +  +S +   + L +  E 
Sbjct: 928  EKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEI 987

Query: 1105 ----SKLKQVKKNGIVDRLFEQQLPDMKKKLWKFVDDQLDYLFAKLKKILVCDSKSFGR- 1159
                  +KQ+K NG  D   E++   ++ K  K  D+  DY             KS G+ 
Sbjct: 988  CHFPKGIKQIK-NGTTDG--EKKSKKIRDKTSKKKDELSDYA-----------EKSTGKG 1033

Query: 1160 DSDEGKLEKTSKQNAQYSNSQKRSVDNSNRELLKEKLSKSEDPVHYKSLVGCKKSEE--- 1216
            DS +   +K SK N  Y   +KR          ++  S S+   +     GC  S++   
Sbjct: 1034 DSCDSSEDKKSK-NGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLK 1092

Query: 1217 --NYQDQNNSSINTVKHDIKKNFNICFDNIKNSQSEERSLEVHCPSTPKSEKNEGSSIED 1274
                +++ N S        K+N         +S +EE S +        S K +   +++
Sbjct: 1093 RIELRERRNLS-------SKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKE 1145

Query: 1275 AQTSQHATLKPERSFEILT--------------------EQQASSLTFNLVSDAQMGEIF 1314
             + +   T    +  +I +                    EQ+   +T NLV  +  G   
Sbjct: 1146 KKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQ 1205

Query: 1315 KSLLQGSDLLDSSVNCTEKSEWELKTPEKQLLETLKCESIPA 1356
             S   G + L  SV  T   + +   PE ++ + +  E I A
Sbjct: 1206 SS---GDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKA 1244



 Score = 34.7 bits (78), Expect = 0.95
 Identities = 92/513 (17%), Positives = 185/513 (36%), Gaps = 45/513 (8%)

Query: 82   KCQLQMKELMKKF-KEIQTQNFSLINENQSLK----KNISALIKTARVEINRKDEEISNL 136
            K Q  + ++ +KF K+ Q+   S  ++ QS K    K   +  K   +++ ++ E  S+ 
Sbjct: 918  KVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDG 977

Query: 137  HQRLSE------FPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHRAKSDVSKDVH 190
             ++L E      FP      K   T    K+K ++ ++    D   +D+  KS    D  
Sbjct: 978  TEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKD-ELSDYAEKSTGKGDSC 1036

Query: 191  HSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDI 250
             S+      K G    +K+    L  S  K           Y + E   N   +R ++  
Sbjct: 1037 DSSE-DKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIE 1095

Query: 251  RHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKS-NS 309
               + N  ++R  K++ +G    +    E+S+  +   ++    +     K  K  S  +
Sbjct: 1096 LRERRNLSSKRNTKEIQSGSSSSDAE--ESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRT 1153

Query: 310  DSDYKGERINSSWEKETPGERSHSRVDSQSDK-KLERQSERSQNINRKEVKSQDKEERKV 368
             +  K   I SS   +   +  +S  +  SD+ K++  +E     +         +E   
Sbjct: 1154 STKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALS 1213

Query: 369  DQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSF 428
               P +V  D D      R +      EI  + +S +    +    E  KR    N  + 
Sbjct: 1214 KSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENP 1273

Query: 429  QDGRCPSSLSNSRTHKNIDSKEVDAMHQW-------------ENTPLKAERHRTEDKRKR 475
             D    + +++     + +SK+    H+              E    K + H+    R R
Sbjct: 1274 GDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNR 1333

Query: 476  EQESKEENR--------------HIRNEKRVPTEHLQKTN-KETKKTTTDLKKQNEPKTD 520
             + S E++                  +E+R  T   +K   +E +++    KK+   K  
Sbjct: 1334 RKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQ 1393

Query: 521  KGEVLDNGVSEGADNKELAMKAESGPNETKNKD 553
            +    +N  +   + +E   + E    E + ++
Sbjct: 1394 EDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEE 1426



 Score = 33.1 bits (74), Expect = 2.8
 Identities = 88/449 (19%), Positives = 163/449 (36%), Gaps = 97/449 (21%)

Query: 898  TSKSQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKNSKR 957
            TSK + +L+   +K   K D C  ++  K+      + G    + +  K      K+S++
Sbjct: 1015 TSKKKDELSDYAEKSTGKGDSCDSSEDKKS------KNGAYGREKKRCK---LLGKSSRK 1065

Query: 958  RVSADVRKSKTIPRRGKSTVCLDKDSRKTHVRIHQTNNKWNKRPDKSSRS---------S 1008
            R   D   S T     K   C   D R   + + +  N  +KR  K  +S         S
Sbjct: 1066 R--QDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEES 1123

Query: 1009 KTEKKDKVMSTSSLEKIVPIIAVPSSEQEIMHMLRMIRKHVRKNYMKFKAKFSLIQFHRI 1068
              + K K   TSS +K V                  I K  ++N ++   K       R 
Sbjct: 1124 SEDNKKKKQRTSSKKKAV------------------IVKEKKRNSLRTSTK-------RK 1158

Query: 1069 IESAILSFTSLIKHLNLHKISKSVTTLQKNLCDIIESKLKQVKKNGIVDRL--FEQQLPD 1126
                  S +S I+  + + I +  +          E K+K V +N ++     F Q   D
Sbjct: 1159 QADITSSSSSDIEDDDQNSIGEGSSD---------EQKIKPVTENLVLSSHTGFCQSSGD 1209

Query: 1127 --MKKKLWKFVDDQLD-----------YLFAKLKKILVCDSKSFGRDSDEGKLEKTSKQN 1173
              + K +   VDD  D            L  ++K  L  D      D  E   ++T KQN
Sbjct: 1210 EALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQN 1269

Query: 1174 AQY---------------SNSQKRSVDNSNRELLKEKLS---------KSEDPVHYKSLV 1209
             +                S+S++         LL+ KL+         K   P  +K + 
Sbjct: 1270 EENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVK 1329

Query: 1210 GCKKSEENYQDQNNSSI--NTVKHDIKKNFNICFDNIKNSQSEERSLEVHCPSTPKSEKN 1267
            G  + + + +D  +S    + V  ++ ++ +      ++++  E  LE +  S  + +K 
Sbjct: 1330 GRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAE--LEENQRSYKQKKKR 1387

Query: 1268 EGSSIEDAQTSQHATLKPERSFEILTEQQ 1296
                +++  +S++ +   E   E   E++
Sbjct: 1388 RRIKVQEDSSSENKSNSEEEEEEKEEEEE 1416


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.308    0.124    0.346 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 76,083,022
Number of Sequences: 37866
Number of extensions: 3615787
Number of successful extensions: 19286
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 102
Number of HSP's successfully gapped in prelim test: 685
Number of HSP's that attempted gapping in prelim test: 14216
Number of HSP's gapped (non-prelim): 4482
length of query: 1982
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1865
effective length of database: 13,817,196
effective search space: 25769070540
effective search space used: 25769070540
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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