BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|212549532 caspase 8 associated protein 2 [Homo sapiens] (1982 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|212549782 caspase 8 associated protein 2 [Homo sapiens] 3954 0.0 gi|6912288 caspase 8 associated protein 2 [Homo sapiens] 3954 0.0 gi|212549532 caspase 8 associated protein 2 [Homo sapiens] 3954 0.0 gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens] 76 4e-13 gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens] 76 4e-13 gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ... 70 2e-11 gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [... 70 2e-11 gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens] 62 4e-09 gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain ... 62 4e-09 gi|42560244 peptidylprolyl isomerase G [Homo sapiens] 62 6e-09 gi|87299628 biorientation of chromosomes in cell division 1-like... 62 7e-09 gi|82830424 gon-4-like isoform a [Homo sapiens] 62 7e-09 gi|109255228 centrosomal protein 170kDa isoform alpha [Homo sapi... 61 1e-08 gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 60 2e-08 gi|109255230 centrosomal protein 170kDa isoform beta [Homo sapiens] 60 2e-08 gi|109255232 centrosomal protein 170kDa isoform gamma [Homo sapi... 60 2e-08 gi|148746195 trichohyalin [Homo sapiens] 60 3e-08 gi|6631100 natural killer-tumor recognition sequence [Homo sapiens] 59 4e-08 gi|239747174 PREDICTED: hypothetical protein XP_002343931, parti... 59 5e-08 gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 58 1e-07 gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 57 1e-07 gi|50962882 G patch domain containing 8 [Homo sapiens] 57 1e-07 gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 57 2e-07 gi|71061468 centromere protein E [Homo sapiens] 56 3e-07 gi|154146223 splicing factor, arginine/serine-rich 130 [Homo sap... 56 3e-07 gi|154146193 splicing factor, arginine/serine-rich 130 [Homo sap... 56 3e-07 gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens] 55 5e-07 gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 55 7e-07 gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 55 7e-07 gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 55 7e-07 >gi|212549782 caspase 8 associated protein 2 [Homo sapiens] Length = 1982 Score = 3954 bits (10253), Expect = 0.0 Identities = 1982/1982 (100%), Positives = 1982/1982 (100%) Query: 1 MAADDDNGDGTSLFDVFSASPLKNNDEGSLDIYAGLDSAVSDSASKSCVPSRNCLDLYEE 60 MAADDDNGDGTSLFDVFSASPLKNNDEGSLDIYAGLDSAVSDSASKSCVPSRNCLDLYEE Sbjct: 1 MAADDDNGDGTSLFDVFSASPLKNNDEGSLDIYAGLDSAVSDSASKSCVPSRNCLDLYEE 60 Query: 61 ILTEEGTAKEATYNDLQVEYGKCQLQMKELMKKFKEIQTQNFSLINENQSLKKNISALIK 120 ILTEEGTAKEATYNDLQVEYGKCQLQMKELMKKFKEIQTQNFSLINENQSLKKNISALIK Sbjct: 61 ILTEEGTAKEATYNDLQVEYGKCQLQMKELMKKFKEIQTQNFSLINENQSLKKNISALIK 120 Query: 121 TARVEINRKDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHR 180 TARVEINRKDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHR Sbjct: 121 TARVEINRKDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHR 180 Query: 181 AKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSN 240 AKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSN Sbjct: 181 AKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSN 240 Query: 241 EDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTES 300 EDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTES Sbjct: 241 EDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTES 300 Query: 301 KSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKS 360 KSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKS Sbjct: 301 KSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKS 360 Query: 361 QDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRD 420 QDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRD Sbjct: 361 QDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRD 420 Query: 421 KSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESK 480 KSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESK Sbjct: 421 KSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESK 480 Query: 481 EENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAM 540 EENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAM Sbjct: 481 EENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAM 540 Query: 541 KAESGPNETKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITDIPKSSGVCDSESSMQV 600 KAESGPNETKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITDIPKSSGVCDSESSMQV Sbjct: 541 KAESGPNETKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITDIPKSSGVCDSESSMQV 600 Query: 601 KTVAYVPSISEHILGEAAVSEHTMGETKSTLLEPKVALLAVTEPRIGISETNKEDENSLL 660 KTVAYVPSISEHILGEAAVSEHTMGETKSTLLEPKVALLAVTEPRIGISETNKEDENSLL Sbjct: 601 KTVAYVPSISEHILGEAAVSEHTMGETKSTLLEPKVALLAVTEPRIGISETNKEDENSLL 660 Query: 661 VRSVDNTMHCEEPICGTETSFPSPMEIQQTESLFPSTGMKQTINNGRAAAPVVMDVLQTD 720 VRSVDNTMHCEEPICGTETSFPSPMEIQQTESLFPSTGMKQTINNGRAAAPVVMDVLQTD Sbjct: 661 VRSVDNTMHCEEPICGTETSFPSPMEIQQTESLFPSTGMKQTINNGRAAAPVVMDVLQTD 720 Query: 721 VSQNFGLELDTKRNDNSDYCGISEGMEMKVALSTTVSETTESILQPSIEEADILPIMLSE 780 VSQNFGLELDTKRNDNSDYCGISEGMEMKVALSTTVSETTESILQPSIEEADILPIMLSE Sbjct: 721 VSQNFGLELDTKRNDNSDYCGISEGMEMKVALSTTVSETTESILQPSIEEADILPIMLSE 780 Query: 781 DNNPKFEPSVIVTPLVESKSCHLEPCLPKETLDSSLQQTELMDHRMATGETNSVYHDDDN 840 DNNPKFEPSVIVTPLVESKSCHLEPCLPKETLDSSLQQTELMDHRMATGETNSVYHDDDN Sbjct: 781 DNNPKFEPSVIVTPLVESKSCHLEPCLPKETLDSSLQQTELMDHRMATGETNSVYHDDDN 840 Query: 841 SVLSIDLNHLRPIPEAISPLNSPVRPVAKVLRNESPPQVPVYNNSHKDVFLPNSAHSTSK 900 SVLSIDLNHLRPIPEAISPLNSPVRPVAKVLRNESPPQVPVYNNSHKDVFLPNSAHSTSK Sbjct: 841 SVLSIDLNHLRPIPEAISPLNSPVRPVAKVLRNESPPQVPVYNNSHKDVFLPNSAHSTSK 900 Query: 901 SQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKNSKRRVS 960 SQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKNSKRRVS Sbjct: 901 SQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKNSKRRVS 960 Query: 961 ADVRKSKTIPRRGKSTVCLDKDSRKTHVRIHQTNNKWNKRPDKSSRSSKTEKKDKVMSTS 1020 ADVRKSKTIPRRGKSTVCLDKDSRKTHVRIHQTNNKWNKRPDKSSRSSKTEKKDKVMSTS Sbjct: 961 ADVRKSKTIPRRGKSTVCLDKDSRKTHVRIHQTNNKWNKRPDKSSRSSKTEKKDKVMSTS 1020 Query: 1021 SLEKIVPIIAVPSSEQEIMHMLRMIRKHVRKNYMKFKAKFSLIQFHRIIESAILSFTSLI 1080 SLEKIVPIIAVPSSEQEIMHMLRMIRKHVRKNYMKFKAKFSLIQFHRIIESAILSFTSLI Sbjct: 1021 SLEKIVPIIAVPSSEQEIMHMLRMIRKHVRKNYMKFKAKFSLIQFHRIIESAILSFTSLI 1080 Query: 1081 KHLNLHKISKSVTTLQKNLCDIIESKLKQVKKNGIVDRLFEQQLPDMKKKLWKFVDDQLD 1140 KHLNLHKISKSVTTLQKNLCDIIESKLKQVKKNGIVDRLFEQQLPDMKKKLWKFVDDQLD Sbjct: 1081 KHLNLHKISKSVTTLQKNLCDIIESKLKQVKKNGIVDRLFEQQLPDMKKKLWKFVDDQLD 1140 Query: 1141 YLFAKLKKILVCDSKSFGRDSDEGKLEKTSKQNAQYSNSQKRSVDNSNRELLKEKLSKSE 1200 YLFAKLKKILVCDSKSFGRDSDEGKLEKTSKQNAQYSNSQKRSVDNSNRELLKEKLSKSE Sbjct: 1141 YLFAKLKKILVCDSKSFGRDSDEGKLEKTSKQNAQYSNSQKRSVDNSNRELLKEKLSKSE 1200 Query: 1201 DPVHYKSLVGCKKSEENYQDQNNSSINTVKHDIKKNFNICFDNIKNSQSEERSLEVHCPS 1260 DPVHYKSLVGCKKSEENYQDQNNSSINTVKHDIKKNFNICFDNIKNSQSEERSLEVHCPS Sbjct: 1201 DPVHYKSLVGCKKSEENYQDQNNSSINTVKHDIKKNFNICFDNIKNSQSEERSLEVHCPS 1260 Query: 1261 TPKSEKNEGSSIEDAQTSQHATLKPERSFEILTEQQASSLTFNLVSDAQMGEIFKSLLQG 1320 TPKSEKNEGSSIEDAQTSQHATLKPERSFEILTEQQASSLTFNLVSDAQMGEIFKSLLQG Sbjct: 1261 TPKSEKNEGSSIEDAQTSQHATLKPERSFEILTEQQASSLTFNLVSDAQMGEIFKSLLQG 1320 Query: 1321 SDLLDSSVNCTEKSEWELKTPEKQLLETLKCESIPACTTEELVSGVASPCPKMISDDNWS 1380 SDLLDSSVNCTEKSEWELKTPEKQLLETLKCESIPACTTEELVSGVASPCPKMISDDNWS Sbjct: 1321 SDLLDSSVNCTEKSEWELKTPEKQLLETLKCESIPACTTEELVSGVASPCPKMISDDNWS 1380 Query: 1381 LLSSEKGPSLSSGLSLPVHPDVLDESCMFEVSTNLPLSKDNVCSVEKSKPCVSSILLEDL 1440 LLSSEKGPSLSSGLSLPVHPDVLDESCMFEVSTNLPLSKDNVCSVEKSKPCVSSILLEDL Sbjct: 1381 LLSSEKGPSLSSGLSLPVHPDVLDESCMFEVSTNLPLSKDNVCSVEKSKPCVSSILLEDL 1440 Query: 1441 AVSLTVPSPLKSDGHLSFLKPDMSSSSTPEEVISAHFSEDALLEEEDASEQDIHLALESD 1500 AVSLTVPSPLKSDGHLSFLKPDMSSSSTPEEVISAHFSEDALLEEEDASEQDIHLALESD Sbjct: 1441 AVSLTVPSPLKSDGHLSFLKPDMSSSSTPEEVISAHFSEDALLEEEDASEQDIHLALESD 1500 Query: 1501 NSSSKSSCSSSWTSRSVAPGFQYHPNLPMHAVIMEKSNDHFIVKIRRATPSTSSGLKQSM 1560 NSSSKSSCSSSWTSRSVAPGFQYHPNLPMHAVIMEKSNDHFIVKIRRATPSTSSGLKQSM Sbjct: 1501 NSSSKSSCSSSWTSRSVAPGFQYHPNLPMHAVIMEKSNDHFIVKIRRATPSTSSGLKQSM 1560 Query: 1561 MPDELLTSLPRHGKEADEGPEKEYISCQNTVFKSVEELENSNKNVDGSKSTHEEQSSMIQ 1620 MPDELLTSLPRHGKEADEGPEKEYISCQNTVFKSVEELENSNKNVDGSKSTHEEQSSMIQ Sbjct: 1561 MPDELLTSLPRHGKEADEGPEKEYISCQNTVFKSVEELENSNKNVDGSKSTHEEQSSMIQ 1620 Query: 1621 TQVPDIYEFLKDASDKMGHSDEVADECFKLHQVWETKVPESIEELPSMEEISHSVGEHLP 1680 TQVPDIYEFLKDASDKMGHSDEVADECFKLHQVWETKVPESIEELPSMEEISHSVGEHLP Sbjct: 1621 TQVPDIYEFLKDASDKMGHSDEVADECFKLHQVWETKVPESIEELPSMEEISHSVGEHLP 1680 Query: 1681 NTYVDLTKDPVTETKNLGEFIEVTVLHIDQLGCSGGNLNQSAQILDNSLQADTVGAFIDL 1740 NTYVDLTKDPVTETKNLGEFIEVTVLHIDQLGCSGGNLNQSAQILDNSLQADTVGAFIDL Sbjct: 1681 NTYVDLTKDPVTETKNLGEFIEVTVLHIDQLGCSGGNLNQSAQILDNSLQADTVGAFIDL 1740 Query: 1741 TQDASSEAKSEGNHPALAVEDLGCGVIQVDEDNCKEEKAQVANRPLKCIVEETYIDLTTE 1800 TQDASSEAKSEGNHPALAVEDLGCGVIQVDEDNCKEEKAQVANRPLKCIVEETYIDLTTE Sbjct: 1741 TQDASSEAKSEGNHPALAVEDLGCGVIQVDEDNCKEEKAQVANRPLKCIVEETYIDLTTE 1800 Query: 1801 SPSSCEVKKDELKSEPGSNCDNSELPGTLHNSHKKRRNISDLNHPHKKQRKETDLTNKEK 1860 SPSSCEVKKDELKSEPGSNCDNSELPGTLHNSHKKRRNISDLNHPHKKQRKETDLTNKEK Sbjct: 1801 SPSSCEVKKDELKSEPGSNCDNSELPGTLHNSHKKRRNISDLNHPHKKQRKETDLTNKEK 1860 Query: 1861 TKKPTQDSCENTEAHQKKASKKKAPPVTKDPSSLKATPGIKDSSAALATSTSLSAKNVIK 1920 TKKPTQDSCENTEAHQKKASKKKAPPVTKDPSSLKATPGIKDSSAALATSTSLSAKNVIK Sbjct: 1861 TKKPTQDSCENTEAHQKKASKKKAPPVTKDPSSLKATPGIKDSSAALATSTSLSAKNVIK 1920 Query: 1921 KKGEIIILWTRNDDREILLECQKRGPSFKTFAYLAAKLDKNPNQVSERFQQLMKLFEKSK 1980 KKGEIIILWTRNDDREILLECQKRGPSFKTFAYLAAKLDKNPNQVSERFQQLMKLFEKSK Sbjct: 1921 KKGEIIILWTRNDDREILLECQKRGPSFKTFAYLAAKLDKNPNQVSERFQQLMKLFEKSK 1980 Query: 1981 CR 1982 CR Sbjct: 1981 CR 1982 >gi|6912288 caspase 8 associated protein 2 [Homo sapiens] Length = 1982 Score = 3954 bits (10253), Expect = 0.0 Identities = 1982/1982 (100%), Positives = 1982/1982 (100%) Query: 1 MAADDDNGDGTSLFDVFSASPLKNNDEGSLDIYAGLDSAVSDSASKSCVPSRNCLDLYEE 60 MAADDDNGDGTSLFDVFSASPLKNNDEGSLDIYAGLDSAVSDSASKSCVPSRNCLDLYEE Sbjct: 1 MAADDDNGDGTSLFDVFSASPLKNNDEGSLDIYAGLDSAVSDSASKSCVPSRNCLDLYEE 60 Query: 61 ILTEEGTAKEATYNDLQVEYGKCQLQMKELMKKFKEIQTQNFSLINENQSLKKNISALIK 120 ILTEEGTAKEATYNDLQVEYGKCQLQMKELMKKFKEIQTQNFSLINENQSLKKNISALIK Sbjct: 61 ILTEEGTAKEATYNDLQVEYGKCQLQMKELMKKFKEIQTQNFSLINENQSLKKNISALIK 120 Query: 121 TARVEINRKDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHR 180 TARVEINRKDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHR Sbjct: 121 TARVEINRKDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHR 180 Query: 181 AKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSN 240 AKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSN Sbjct: 181 AKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSN 240 Query: 241 EDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTES 300 EDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTES Sbjct: 241 EDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTES 300 Query: 301 KSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKS 360 KSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKS Sbjct: 301 KSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKS 360 Query: 361 QDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRD 420 QDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRD Sbjct: 361 QDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRD 420 Query: 421 KSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESK 480 KSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESK Sbjct: 421 KSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESK 480 Query: 481 EENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAM 540 EENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAM Sbjct: 481 EENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAM 540 Query: 541 KAESGPNETKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITDIPKSSGVCDSESSMQV 600 KAESGPNETKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITDIPKSSGVCDSESSMQV Sbjct: 541 KAESGPNETKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITDIPKSSGVCDSESSMQV 600 Query: 601 KTVAYVPSISEHILGEAAVSEHTMGETKSTLLEPKVALLAVTEPRIGISETNKEDENSLL 660 KTVAYVPSISEHILGEAAVSEHTMGETKSTLLEPKVALLAVTEPRIGISETNKEDENSLL Sbjct: 601 KTVAYVPSISEHILGEAAVSEHTMGETKSTLLEPKVALLAVTEPRIGISETNKEDENSLL 660 Query: 661 VRSVDNTMHCEEPICGTETSFPSPMEIQQTESLFPSTGMKQTINNGRAAAPVVMDVLQTD 720 VRSVDNTMHCEEPICGTETSFPSPMEIQQTESLFPSTGMKQTINNGRAAAPVVMDVLQTD Sbjct: 661 VRSVDNTMHCEEPICGTETSFPSPMEIQQTESLFPSTGMKQTINNGRAAAPVVMDVLQTD 720 Query: 721 VSQNFGLELDTKRNDNSDYCGISEGMEMKVALSTTVSETTESILQPSIEEADILPIMLSE 780 VSQNFGLELDTKRNDNSDYCGISEGMEMKVALSTTVSETTESILQPSIEEADILPIMLSE Sbjct: 721 VSQNFGLELDTKRNDNSDYCGISEGMEMKVALSTTVSETTESILQPSIEEADILPIMLSE 780 Query: 781 DNNPKFEPSVIVTPLVESKSCHLEPCLPKETLDSSLQQTELMDHRMATGETNSVYHDDDN 840 DNNPKFEPSVIVTPLVESKSCHLEPCLPKETLDSSLQQTELMDHRMATGETNSVYHDDDN Sbjct: 781 DNNPKFEPSVIVTPLVESKSCHLEPCLPKETLDSSLQQTELMDHRMATGETNSVYHDDDN 840 Query: 841 SVLSIDLNHLRPIPEAISPLNSPVRPVAKVLRNESPPQVPVYNNSHKDVFLPNSAHSTSK 900 SVLSIDLNHLRPIPEAISPLNSPVRPVAKVLRNESPPQVPVYNNSHKDVFLPNSAHSTSK Sbjct: 841 SVLSIDLNHLRPIPEAISPLNSPVRPVAKVLRNESPPQVPVYNNSHKDVFLPNSAHSTSK 900 Query: 901 SQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKNSKRRVS 960 SQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKNSKRRVS Sbjct: 901 SQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKNSKRRVS 960 Query: 961 ADVRKSKTIPRRGKSTVCLDKDSRKTHVRIHQTNNKWNKRPDKSSRSSKTEKKDKVMSTS 1020 ADVRKSKTIPRRGKSTVCLDKDSRKTHVRIHQTNNKWNKRPDKSSRSSKTEKKDKVMSTS Sbjct: 961 ADVRKSKTIPRRGKSTVCLDKDSRKTHVRIHQTNNKWNKRPDKSSRSSKTEKKDKVMSTS 1020 Query: 1021 SLEKIVPIIAVPSSEQEIMHMLRMIRKHVRKNYMKFKAKFSLIQFHRIIESAILSFTSLI 1080 SLEKIVPIIAVPSSEQEIMHMLRMIRKHVRKNYMKFKAKFSLIQFHRIIESAILSFTSLI Sbjct: 1021 SLEKIVPIIAVPSSEQEIMHMLRMIRKHVRKNYMKFKAKFSLIQFHRIIESAILSFTSLI 1080 Query: 1081 KHLNLHKISKSVTTLQKNLCDIIESKLKQVKKNGIVDRLFEQQLPDMKKKLWKFVDDQLD 1140 KHLNLHKISKSVTTLQKNLCDIIESKLKQVKKNGIVDRLFEQQLPDMKKKLWKFVDDQLD Sbjct: 1081 KHLNLHKISKSVTTLQKNLCDIIESKLKQVKKNGIVDRLFEQQLPDMKKKLWKFVDDQLD 1140 Query: 1141 YLFAKLKKILVCDSKSFGRDSDEGKLEKTSKQNAQYSNSQKRSVDNSNRELLKEKLSKSE 1200 YLFAKLKKILVCDSKSFGRDSDEGKLEKTSKQNAQYSNSQKRSVDNSNRELLKEKLSKSE Sbjct: 1141 YLFAKLKKILVCDSKSFGRDSDEGKLEKTSKQNAQYSNSQKRSVDNSNRELLKEKLSKSE 1200 Query: 1201 DPVHYKSLVGCKKSEENYQDQNNSSINTVKHDIKKNFNICFDNIKNSQSEERSLEVHCPS 1260 DPVHYKSLVGCKKSEENYQDQNNSSINTVKHDIKKNFNICFDNIKNSQSEERSLEVHCPS Sbjct: 1201 DPVHYKSLVGCKKSEENYQDQNNSSINTVKHDIKKNFNICFDNIKNSQSEERSLEVHCPS 1260 Query: 1261 TPKSEKNEGSSIEDAQTSQHATLKPERSFEILTEQQASSLTFNLVSDAQMGEIFKSLLQG 1320 TPKSEKNEGSSIEDAQTSQHATLKPERSFEILTEQQASSLTFNLVSDAQMGEIFKSLLQG Sbjct: 1261 TPKSEKNEGSSIEDAQTSQHATLKPERSFEILTEQQASSLTFNLVSDAQMGEIFKSLLQG 1320 Query: 1321 SDLLDSSVNCTEKSEWELKTPEKQLLETLKCESIPACTTEELVSGVASPCPKMISDDNWS 1380 SDLLDSSVNCTEKSEWELKTPEKQLLETLKCESIPACTTEELVSGVASPCPKMISDDNWS Sbjct: 1321 SDLLDSSVNCTEKSEWELKTPEKQLLETLKCESIPACTTEELVSGVASPCPKMISDDNWS 1380 Query: 1381 LLSSEKGPSLSSGLSLPVHPDVLDESCMFEVSTNLPLSKDNVCSVEKSKPCVSSILLEDL 1440 LLSSEKGPSLSSGLSLPVHPDVLDESCMFEVSTNLPLSKDNVCSVEKSKPCVSSILLEDL Sbjct: 1381 LLSSEKGPSLSSGLSLPVHPDVLDESCMFEVSTNLPLSKDNVCSVEKSKPCVSSILLEDL 1440 Query: 1441 AVSLTVPSPLKSDGHLSFLKPDMSSSSTPEEVISAHFSEDALLEEEDASEQDIHLALESD 1500 AVSLTVPSPLKSDGHLSFLKPDMSSSSTPEEVISAHFSEDALLEEEDASEQDIHLALESD Sbjct: 1441 AVSLTVPSPLKSDGHLSFLKPDMSSSSTPEEVISAHFSEDALLEEEDASEQDIHLALESD 1500 Query: 1501 NSSSKSSCSSSWTSRSVAPGFQYHPNLPMHAVIMEKSNDHFIVKIRRATPSTSSGLKQSM 1560 NSSSKSSCSSSWTSRSVAPGFQYHPNLPMHAVIMEKSNDHFIVKIRRATPSTSSGLKQSM Sbjct: 1501 NSSSKSSCSSSWTSRSVAPGFQYHPNLPMHAVIMEKSNDHFIVKIRRATPSTSSGLKQSM 1560 Query: 1561 MPDELLTSLPRHGKEADEGPEKEYISCQNTVFKSVEELENSNKNVDGSKSTHEEQSSMIQ 1620 MPDELLTSLPRHGKEADEGPEKEYISCQNTVFKSVEELENSNKNVDGSKSTHEEQSSMIQ Sbjct: 1561 MPDELLTSLPRHGKEADEGPEKEYISCQNTVFKSVEELENSNKNVDGSKSTHEEQSSMIQ 1620 Query: 1621 TQVPDIYEFLKDASDKMGHSDEVADECFKLHQVWETKVPESIEELPSMEEISHSVGEHLP 1680 TQVPDIYEFLKDASDKMGHSDEVADECFKLHQVWETKVPESIEELPSMEEISHSVGEHLP Sbjct: 1621 TQVPDIYEFLKDASDKMGHSDEVADECFKLHQVWETKVPESIEELPSMEEISHSVGEHLP 1680 Query: 1681 NTYVDLTKDPVTETKNLGEFIEVTVLHIDQLGCSGGNLNQSAQILDNSLQADTVGAFIDL 1740 NTYVDLTKDPVTETKNLGEFIEVTVLHIDQLGCSGGNLNQSAQILDNSLQADTVGAFIDL Sbjct: 1681 NTYVDLTKDPVTETKNLGEFIEVTVLHIDQLGCSGGNLNQSAQILDNSLQADTVGAFIDL 1740 Query: 1741 TQDASSEAKSEGNHPALAVEDLGCGVIQVDEDNCKEEKAQVANRPLKCIVEETYIDLTTE 1800 TQDASSEAKSEGNHPALAVEDLGCGVIQVDEDNCKEEKAQVANRPLKCIVEETYIDLTTE Sbjct: 1741 TQDASSEAKSEGNHPALAVEDLGCGVIQVDEDNCKEEKAQVANRPLKCIVEETYIDLTTE 1800 Query: 1801 SPSSCEVKKDELKSEPGSNCDNSELPGTLHNSHKKRRNISDLNHPHKKQRKETDLTNKEK 1860 SPSSCEVKKDELKSEPGSNCDNSELPGTLHNSHKKRRNISDLNHPHKKQRKETDLTNKEK Sbjct: 1801 SPSSCEVKKDELKSEPGSNCDNSELPGTLHNSHKKRRNISDLNHPHKKQRKETDLTNKEK 1860 Query: 1861 TKKPTQDSCENTEAHQKKASKKKAPPVTKDPSSLKATPGIKDSSAALATSTSLSAKNVIK 1920 TKKPTQDSCENTEAHQKKASKKKAPPVTKDPSSLKATPGIKDSSAALATSTSLSAKNVIK Sbjct: 1861 TKKPTQDSCENTEAHQKKASKKKAPPVTKDPSSLKATPGIKDSSAALATSTSLSAKNVIK 1920 Query: 1921 KKGEIIILWTRNDDREILLECQKRGPSFKTFAYLAAKLDKNPNQVSERFQQLMKLFEKSK 1980 KKGEIIILWTRNDDREILLECQKRGPSFKTFAYLAAKLDKNPNQVSERFQQLMKLFEKSK Sbjct: 1921 KKGEIIILWTRNDDREILLECQKRGPSFKTFAYLAAKLDKNPNQVSERFQQLMKLFEKSK 1980 Query: 1981 CR 1982 CR Sbjct: 1981 CR 1982 >gi|212549532 caspase 8 associated protein 2 [Homo sapiens] Length = 1982 Score = 3954 bits (10253), Expect = 0.0 Identities = 1982/1982 (100%), Positives = 1982/1982 (100%) Query: 1 MAADDDNGDGTSLFDVFSASPLKNNDEGSLDIYAGLDSAVSDSASKSCVPSRNCLDLYEE 60 MAADDDNGDGTSLFDVFSASPLKNNDEGSLDIYAGLDSAVSDSASKSCVPSRNCLDLYEE Sbjct: 1 MAADDDNGDGTSLFDVFSASPLKNNDEGSLDIYAGLDSAVSDSASKSCVPSRNCLDLYEE 60 Query: 61 ILTEEGTAKEATYNDLQVEYGKCQLQMKELMKKFKEIQTQNFSLINENQSLKKNISALIK 120 ILTEEGTAKEATYNDLQVEYGKCQLQMKELMKKFKEIQTQNFSLINENQSLKKNISALIK Sbjct: 61 ILTEEGTAKEATYNDLQVEYGKCQLQMKELMKKFKEIQTQNFSLINENQSLKKNISALIK 120 Query: 121 TARVEINRKDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHR 180 TARVEINRKDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHR Sbjct: 121 TARVEINRKDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHR 180 Query: 181 AKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSN 240 AKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSN Sbjct: 181 AKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSN 240 Query: 241 EDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTES 300 EDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTES Sbjct: 241 EDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTES 300 Query: 301 KSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKS 360 KSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKS Sbjct: 301 KSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKS 360 Query: 361 QDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRD 420 QDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRD Sbjct: 361 QDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRD 420 Query: 421 KSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESK 480 KSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESK Sbjct: 421 KSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESK 480 Query: 481 EENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAM 540 EENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAM Sbjct: 481 EENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAM 540 Query: 541 KAESGPNETKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITDIPKSSGVCDSESSMQV 600 KAESGPNETKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITDIPKSSGVCDSESSMQV Sbjct: 541 KAESGPNETKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITDIPKSSGVCDSESSMQV 600 Query: 601 KTVAYVPSISEHILGEAAVSEHTMGETKSTLLEPKVALLAVTEPRIGISETNKEDENSLL 660 KTVAYVPSISEHILGEAAVSEHTMGETKSTLLEPKVALLAVTEPRIGISETNKEDENSLL Sbjct: 601 KTVAYVPSISEHILGEAAVSEHTMGETKSTLLEPKVALLAVTEPRIGISETNKEDENSLL 660 Query: 661 VRSVDNTMHCEEPICGTETSFPSPMEIQQTESLFPSTGMKQTINNGRAAAPVVMDVLQTD 720 VRSVDNTMHCEEPICGTETSFPSPMEIQQTESLFPSTGMKQTINNGRAAAPVVMDVLQTD Sbjct: 661 VRSVDNTMHCEEPICGTETSFPSPMEIQQTESLFPSTGMKQTINNGRAAAPVVMDVLQTD 720 Query: 721 VSQNFGLELDTKRNDNSDYCGISEGMEMKVALSTTVSETTESILQPSIEEADILPIMLSE 780 VSQNFGLELDTKRNDNSDYCGISEGMEMKVALSTTVSETTESILQPSIEEADILPIMLSE Sbjct: 721 VSQNFGLELDTKRNDNSDYCGISEGMEMKVALSTTVSETTESILQPSIEEADILPIMLSE 780 Query: 781 DNNPKFEPSVIVTPLVESKSCHLEPCLPKETLDSSLQQTELMDHRMATGETNSVYHDDDN 840 DNNPKFEPSVIVTPLVESKSCHLEPCLPKETLDSSLQQTELMDHRMATGETNSVYHDDDN Sbjct: 781 DNNPKFEPSVIVTPLVESKSCHLEPCLPKETLDSSLQQTELMDHRMATGETNSVYHDDDN 840 Query: 841 SVLSIDLNHLRPIPEAISPLNSPVRPVAKVLRNESPPQVPVYNNSHKDVFLPNSAHSTSK 900 SVLSIDLNHLRPIPEAISPLNSPVRPVAKVLRNESPPQVPVYNNSHKDVFLPNSAHSTSK Sbjct: 841 SVLSIDLNHLRPIPEAISPLNSPVRPVAKVLRNESPPQVPVYNNSHKDVFLPNSAHSTSK 900 Query: 901 SQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKNSKRRVS 960 SQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKNSKRRVS Sbjct: 901 SQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKNSKRRVS 960 Query: 961 ADVRKSKTIPRRGKSTVCLDKDSRKTHVRIHQTNNKWNKRPDKSSRSSKTEKKDKVMSTS 1020 ADVRKSKTIPRRGKSTVCLDKDSRKTHVRIHQTNNKWNKRPDKSSRSSKTEKKDKVMSTS Sbjct: 961 ADVRKSKTIPRRGKSTVCLDKDSRKTHVRIHQTNNKWNKRPDKSSRSSKTEKKDKVMSTS 1020 Query: 1021 SLEKIVPIIAVPSSEQEIMHMLRMIRKHVRKNYMKFKAKFSLIQFHRIIESAILSFTSLI 1080 SLEKIVPIIAVPSSEQEIMHMLRMIRKHVRKNYMKFKAKFSLIQFHRIIESAILSFTSLI Sbjct: 1021 SLEKIVPIIAVPSSEQEIMHMLRMIRKHVRKNYMKFKAKFSLIQFHRIIESAILSFTSLI 1080 Query: 1081 KHLNLHKISKSVTTLQKNLCDIIESKLKQVKKNGIVDRLFEQQLPDMKKKLWKFVDDQLD 1140 KHLNLHKISKSVTTLQKNLCDIIESKLKQVKKNGIVDRLFEQQLPDMKKKLWKFVDDQLD Sbjct: 1081 KHLNLHKISKSVTTLQKNLCDIIESKLKQVKKNGIVDRLFEQQLPDMKKKLWKFVDDQLD 1140 Query: 1141 YLFAKLKKILVCDSKSFGRDSDEGKLEKTSKQNAQYSNSQKRSVDNSNRELLKEKLSKSE 1200 YLFAKLKKILVCDSKSFGRDSDEGKLEKTSKQNAQYSNSQKRSVDNSNRELLKEKLSKSE Sbjct: 1141 YLFAKLKKILVCDSKSFGRDSDEGKLEKTSKQNAQYSNSQKRSVDNSNRELLKEKLSKSE 1200 Query: 1201 DPVHYKSLVGCKKSEENYQDQNNSSINTVKHDIKKNFNICFDNIKNSQSEERSLEVHCPS 1260 DPVHYKSLVGCKKSEENYQDQNNSSINTVKHDIKKNFNICFDNIKNSQSEERSLEVHCPS Sbjct: 1201 DPVHYKSLVGCKKSEENYQDQNNSSINTVKHDIKKNFNICFDNIKNSQSEERSLEVHCPS 1260 Query: 1261 TPKSEKNEGSSIEDAQTSQHATLKPERSFEILTEQQASSLTFNLVSDAQMGEIFKSLLQG 1320 TPKSEKNEGSSIEDAQTSQHATLKPERSFEILTEQQASSLTFNLVSDAQMGEIFKSLLQG Sbjct: 1261 TPKSEKNEGSSIEDAQTSQHATLKPERSFEILTEQQASSLTFNLVSDAQMGEIFKSLLQG 1320 Query: 1321 SDLLDSSVNCTEKSEWELKTPEKQLLETLKCESIPACTTEELVSGVASPCPKMISDDNWS 1380 SDLLDSSVNCTEKSEWELKTPEKQLLETLKCESIPACTTEELVSGVASPCPKMISDDNWS Sbjct: 1321 SDLLDSSVNCTEKSEWELKTPEKQLLETLKCESIPACTTEELVSGVASPCPKMISDDNWS 1380 Query: 1381 LLSSEKGPSLSSGLSLPVHPDVLDESCMFEVSTNLPLSKDNVCSVEKSKPCVSSILLEDL 1440 LLSSEKGPSLSSGLSLPVHPDVLDESCMFEVSTNLPLSKDNVCSVEKSKPCVSSILLEDL Sbjct: 1381 LLSSEKGPSLSSGLSLPVHPDVLDESCMFEVSTNLPLSKDNVCSVEKSKPCVSSILLEDL 1440 Query: 1441 AVSLTVPSPLKSDGHLSFLKPDMSSSSTPEEVISAHFSEDALLEEEDASEQDIHLALESD 1500 AVSLTVPSPLKSDGHLSFLKPDMSSSSTPEEVISAHFSEDALLEEEDASEQDIHLALESD Sbjct: 1441 AVSLTVPSPLKSDGHLSFLKPDMSSSSTPEEVISAHFSEDALLEEEDASEQDIHLALESD 1500 Query: 1501 NSSSKSSCSSSWTSRSVAPGFQYHPNLPMHAVIMEKSNDHFIVKIRRATPSTSSGLKQSM 1560 NSSSKSSCSSSWTSRSVAPGFQYHPNLPMHAVIMEKSNDHFIVKIRRATPSTSSGLKQSM Sbjct: 1501 NSSSKSSCSSSWTSRSVAPGFQYHPNLPMHAVIMEKSNDHFIVKIRRATPSTSSGLKQSM 1560 Query: 1561 MPDELLTSLPRHGKEADEGPEKEYISCQNTVFKSVEELENSNKNVDGSKSTHEEQSSMIQ 1620 MPDELLTSLPRHGKEADEGPEKEYISCQNTVFKSVEELENSNKNVDGSKSTHEEQSSMIQ Sbjct: 1561 MPDELLTSLPRHGKEADEGPEKEYISCQNTVFKSVEELENSNKNVDGSKSTHEEQSSMIQ 1620 Query: 1621 TQVPDIYEFLKDASDKMGHSDEVADECFKLHQVWETKVPESIEELPSMEEISHSVGEHLP 1680 TQVPDIYEFLKDASDKMGHSDEVADECFKLHQVWETKVPESIEELPSMEEISHSVGEHLP Sbjct: 1621 TQVPDIYEFLKDASDKMGHSDEVADECFKLHQVWETKVPESIEELPSMEEISHSVGEHLP 1680 Query: 1681 NTYVDLTKDPVTETKNLGEFIEVTVLHIDQLGCSGGNLNQSAQILDNSLQADTVGAFIDL 1740 NTYVDLTKDPVTETKNLGEFIEVTVLHIDQLGCSGGNLNQSAQILDNSLQADTVGAFIDL Sbjct: 1681 NTYVDLTKDPVTETKNLGEFIEVTVLHIDQLGCSGGNLNQSAQILDNSLQADTVGAFIDL 1740 Query: 1741 TQDASSEAKSEGNHPALAVEDLGCGVIQVDEDNCKEEKAQVANRPLKCIVEETYIDLTTE 1800 TQDASSEAKSEGNHPALAVEDLGCGVIQVDEDNCKEEKAQVANRPLKCIVEETYIDLTTE Sbjct: 1741 TQDASSEAKSEGNHPALAVEDLGCGVIQVDEDNCKEEKAQVANRPLKCIVEETYIDLTTE 1800 Query: 1801 SPSSCEVKKDELKSEPGSNCDNSELPGTLHNSHKKRRNISDLNHPHKKQRKETDLTNKEK 1860 SPSSCEVKKDELKSEPGSNCDNSELPGTLHNSHKKRRNISDLNHPHKKQRKETDLTNKEK Sbjct: 1801 SPSSCEVKKDELKSEPGSNCDNSELPGTLHNSHKKRRNISDLNHPHKKQRKETDLTNKEK 1860 Query: 1861 TKKPTQDSCENTEAHQKKASKKKAPPVTKDPSSLKATPGIKDSSAALATSTSLSAKNVIK 1920 TKKPTQDSCENTEAHQKKASKKKAPPVTKDPSSLKATPGIKDSSAALATSTSLSAKNVIK Sbjct: 1861 TKKPTQDSCENTEAHQKKASKKKAPPVTKDPSSLKATPGIKDSSAALATSTSLSAKNVIK 1920 Query: 1921 KKGEIIILWTRNDDREILLECQKRGPSFKTFAYLAAKLDKNPNQVSERFQQLMKLFEKSK 1980 KKGEIIILWTRNDDREILLECQKRGPSFKTFAYLAAKLDKNPNQVSERFQQLMKLFEKSK Sbjct: 1921 KKGEIIILWTRNDDREILLECQKRGPSFKTFAYLAAKLDKNPNQVSERFQQLMKLFEKSK 1980 Query: 1981 CR 1982 CR Sbjct: 1981 CR 1982 >gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens] Length = 2039 Score = 75.9 bits (185), Expect = 4e-13 Identities = 124/574 (21%), Positives = 241/574 (41%), Gaps = 81/574 (14%) Query: 94 FKEIQTQNFSLINENQSLKKNISALIKTARVEINRKDEEISNLHQRLSEFPHFRNNH--- 150 FK +T++ L E++SL L K +++E N KD++ S + +S+ +F+ Sbjct: 678 FKSDETEDLFLNMEHESL-----TLEKKSKLEKNIKDDK-STKEKHVSKERNFKEERDKI 731 Query: 151 --KTARTFDTVKTKDLKSRSPHLDDCSKTDHRAKSDVSKDVHHSTSLPNLEKEGKPHSDK 208 ++ ++F K KDLK ++ + D S + S L +EKE + Sbjct: 732 KKESEKSFREEKIKDLKEERENIP--TDKDSEFTSLGMSAIEESIGLHLVEKE---IDIE 786 Query: 209 RSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRGTERVRKDLST 268 + H+ S EK Q+ E + R+ + + + +E+ + DLS Sbjct: 787 KQEKHIKESKEK-------PEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSE 839 Query: 269 GCGDGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPG 328 C D +I E + H EK K K+++ ++ K D + E+++ +KE P Sbjct: 840 -CVD---KIKEKDKLYSHHTEKCHKEGEKSKNTAA-IKKTDDREKSREKMDRKHDKEKPE 894 Query: 329 ERSHSRVDSQSDKKLERQSERSQNIN-RKEVKSQDKE-ERKVDQKPKSVVKDQ------D 380 + H +S+ +E+++++S N K K ++KE +R++D+K KS K+ Sbjct: 895 KERHL-AESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSK 953 Query: 381 HWRRSERASL------PHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCP 434 H + +++S+ H K ++ + L+ G E K+DK ++ + +D Sbjct: 954 HIQEEKKSSIVDGNKAQHEK-PLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERD---- 1008 Query: 435 SSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESKEENRHIRNEKRVPT 494 K+ D +++++ LK + + K K SK+ EKR+ Sbjct: 1009 ---------KHKDKIQINSL-------LKLKSEADKPKPKSSPASKDTRP---KEKRLVN 1049 Query: 495 EHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAMKAESG------PNE 548 + L +T+ E + DL+ + K K ++ + L +K + P E Sbjct: 1050 DDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTE 1109 Query: 549 TKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITD------IPKSSGVCDSESSMQVKT 602 +KNK+L S ++ + K+ + N+ + D + KSS V D+ + ++ Sbjct: 1110 SKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRS 1169 Query: 603 VAYVPSISEHILG--EAAVSEHTMGETKSTLLEP 634 P +S + A SE + T +T P Sbjct: 1170 ENEKPGLSSRSVSMISVASSEDSCHTTVTTPRPP 1203 Score = 53.1 bits (126), Expect = 3e-06 Identities = 100/489 (20%), Positives = 171/489 (34%), Gaps = 83/489 (16%) Query: 158 TVKTKDLKSRSPHLDDCSKTDHRAKSDVSKDVHHSTSLPN-------LEKEGKPHSDKRS 210 +VK+ K +S H D + KD HS + N ++KEGK K Sbjct: 573 SVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLK-KHK 631 Query: 211 TSHLPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRGTERVRKDLSTGC 270 H EKH + Y+ + S+ E R D + N +DL Sbjct: 632 LKHKEREKEKHKKEIEGEKEKYKTKD-SAKELQRSVEFDREFWKENFFKSDETEDLFLNM 690 Query: 271 GDGEPRILEASQRLQGH-------PEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWE 323 + E LE +L+ + EK+ E + + K K S+ ++ E+I Sbjct: 691 -EHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKI----- 744 Query: 324 KETPGERSHSRVDSQSD------------------------KKLERQSERSQNINRKEVK 359 K+ ER + D S+ +K E+ + S+ K + Sbjct: 745 KDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQ 804 Query: 360 SQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSK-------NEITFSHNSSKYHLEERR 412 ++K+ K+++K K H +SE+ L S+ + +SH++ K H E + Sbjct: 805 IKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEK 864 Query: 413 GWEDC----------KRDKSVNSHSFQDGRCPSSLSNSRT-------HKNIDSKEVDAMH 455 R+K H + L+ S+ +K D+ E Sbjct: 865 SKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSE 924 Query: 456 QWENTPLKAERHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQN 515 + +N E + E R +E + ++HI+ EK+ K E + + K Sbjct: 925 KGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDE 984 Query: 516 EPKTDKGEVLDNGVSEGADNKELAMKAESGPNETK---NKDLKLSFMKKLNLTLSPAKKQ 572 KT G+ D +K++ E ++ K N LKL K K Sbjct: 985 PLKTPDGKEKDK------KDKDIDRYKERDKHKDKIQINSLLKL----KSEADKPKPKSS 1034 Query: 573 PVSQDNQHK 581 P S+D + K Sbjct: 1035 PASKDTRPK 1043 Score = 38.9 bits (89), Expect = 0.051 Identities = 82/391 (20%), Positives = 153/391 (39%), Gaps = 72/391 (18%) Query: 900 KSQSDLNKENQKPIYKSDKCT------EADTCKNSPLDELE------EGEIRSDSETSKP 947 KS + + E+ P +++ CT E T K L E + EI + E K Sbjct: 596 KSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKT 655 Query: 948 QESFEKNSKRRVSAD---------------------VRKSKTIPRRGK--STVCLDKDSR 984 ++S K +R V D +S T+ ++ K + DK ++ Sbjct: 656 KDS-AKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTK 714 Query: 985 KTHV----RIHQTNNKWNKRPDKSSRSSKTEK-----------KDKVMSTSSLEKIVPII 1029 + HV + +K K +KS R K + KD ++ + I I Sbjct: 715 EKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESI 774 Query: 1030 AVPSSEQEIMHMLRMIRKHVRKNYMKFKAKFSLIQFHRIIESAILSFTSLIKHLNLHKIS 1089 + E+EI + KH++++ K K S I+ I + +F K + HK Sbjct: 775 GLHLVEKEID--IEKQEKHIKESKEK-PEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSE 831 Query: 1090 KSVTTLQKNLCDIIESKLKQVKKNGIVDRLFEQQLPDMKKKLWKFVDDQ---LDYLFAKL 1146 K L + + D I+ K K + ++ ++ K DD+ + + K Sbjct: 832 KDKLDLSECV-DKIKEKDKLYSHH--TEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKH 888 Query: 1147 KKILVCDSKSFGRDSDEGKLEKTSKQ--NAQYSNSQKRSVDNSNRELLKEKLSKSEDPVH 1204 K + ++ +EK +KQ N++YS S+K +REL K++ S+ ++ ++ Sbjct: 889 DKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESIN 948 Query: 1205 YKSLVGCKKSEENYQDQNNSSI---NTVKHD 1232 + ++ Q++ SSI N +H+ Sbjct: 949 I-------TNSKHIQEEKKSSIVDGNKAQHE 972 Score = 34.7 bits (78), Expect = 0.95 Identities = 90/490 (18%), Positives = 184/490 (37%), Gaps = 76/490 (15%) Query: 125 EINRK--DEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHRAK 182 EIN+ D I QR P H A+ K KS+ K Sbjct: 347 EINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSK--------------K 392 Query: 183 SDVSKDVHHSTSLPNLEK-EGKPHSDKRS----TSHLPTSVEKHCTNGVWSRSHYQVGEG 237 S+ ++ ST + E + K S S TS+ +K V S H Q G+ Sbjct: 393 QKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEY---VVSGEHKQKGKV 449 Query: 238 S---SNEDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKG 294 N++ + ++++ + + R+ +L+ G L+ S++ + Sbjct: 450 KRKLKNQNKNKENQELKQEKEGKENTRIT-NLTVNTG------LDCSEKTREEGNFRKSF 502 Query: 295 EPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRV---DSQSDKKLERQSERSQ 351 PK ++ F ++ K S ++ TP ++ H++ S+ L+ R Sbjct: 503 SPKDDTSLHLFHISTGKSPK-HSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYD 561 Query: 352 NINR---------KEVKSQDKEERKVD------QKPKSVVKDQDH----------WRRSE 386 N K K ++K + + D +K + +KD+DH ++ + Sbjct: 562 NTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMD 621 Query: 387 RASLPHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNI 446 + K+++ + H +E G ++ + K + K+ Sbjct: 622 KEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSD 681 Query: 447 DSKEVDAMHQWENTPL----KAERHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNK 502 +++++ + E+ L K E++ +DK +E+ +E R+ + E+ + +K+ + Sbjct: 682 ETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKE-RNFKEERDKIKKESEKSFR 740 Query: 503 ETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADN-------KELAM-KAESGPNETKNKDL 554 E K +++N P E G+S ++ KE+ + K E E+K K Sbjct: 741 EEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPE 800 Query: 555 KLSFMKKLNL 564 K S +K+ ++ Sbjct: 801 KRSQIKEKDI 810 >gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens] Length = 2062 Score = 75.9 bits (185), Expect = 4e-13 Identities = 124/574 (21%), Positives = 241/574 (41%), Gaps = 81/574 (14%) Query: 94 FKEIQTQNFSLINENQSLKKNISALIKTARVEINRKDEEISNLHQRLSEFPHFRNNH--- 150 FK +T++ L E++SL L K +++E N KD++ S + +S+ +F+ Sbjct: 701 FKSDETEDLFLNMEHESL-----TLEKKSKLEKNIKDDK-STKEKHVSKERNFKEERDKI 754 Query: 151 --KTARTFDTVKTKDLKSRSPHLDDCSKTDHRAKSDVSKDVHHSTSLPNLEKEGKPHSDK 208 ++ ++F K KDLK ++ + D S + S L +EKE + Sbjct: 755 KKESEKSFREEKIKDLKEERENIP--TDKDSEFTSLGMSAIEESIGLHLVEKE---IDIE 809 Query: 209 RSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRGTERVRKDLST 268 + H+ S EK Q+ E + R+ + + + +E+ + DLS Sbjct: 810 KQEKHIKESKEK-------PEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSE 862 Query: 269 GCGDGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPG 328 C D +I E + H EK K K+++ ++ K D + E+++ +KE P Sbjct: 863 -CVD---KIKEKDKLYSHHTEKCHKEGEKSKNTAA-IKKTDDREKSREKMDRKHDKEKPE 917 Query: 329 ERSHSRVDSQSDKKLERQSERSQNIN-RKEVKSQDKE-ERKVDQKPKSVVKDQ------D 380 + H +S+ +E+++++S N K K ++KE +R++D+K KS K+ Sbjct: 918 KERHL-AESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSK 976 Query: 381 HWRRSERASL------PHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCP 434 H + +++S+ H K ++ + L+ G E K+DK ++ + +D Sbjct: 977 HIQEEKKSSIVDGNKAQHEK-PLSLKEKTKDEPLKTPDGKEKDKKDKDIDRYKERD---- 1031 Query: 435 SSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESKEENRHIRNEKRVPT 494 K+ D +++++ LK + + K K SK+ EKR+ Sbjct: 1032 ---------KHKDKIQINSL-------LKLKSEADKPKPKSSPASKDTRP---KEKRLVN 1072 Query: 495 EHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAMKAESG------PNE 548 + L +T+ E + DL+ + K K ++ + L +K + P E Sbjct: 1073 DDLMQTSFERMLSLKDLEIEQWHKKHKEKIKQKEKERLRNRNCLELKIKDKEKTKHTPTE 1132 Query: 549 TKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITD------IPKSSGVCDSESSMQVKT 602 +KNK+L S ++ + K+ + N+ + D + KSS V D+ + ++ Sbjct: 1133 SKNKELTRSKSSEVTDAYTKEKQPKDAVSNRSQSVDTKNVMTLGKSSFVSDNSLNRSPRS 1192 Query: 603 VAYVPSISEHILG--EAAVSEHTMGETKSTLLEP 634 P +S + A SE + T +T P Sbjct: 1193 ENEKPGLSSRSVSMISVASSEDSCHTTVTTPRPP 1226 Score = 53.1 bits (126), Expect = 3e-06 Identities = 100/489 (20%), Positives = 171/489 (34%), Gaps = 83/489 (16%) Query: 158 TVKTKDLKSRSPHLDDCSKTDHRAKSDVSKDVHHSTSLPN-------LEKEGKPHSDKRS 210 +VK+ K +S H D + KD HS + N ++KEGK K Sbjct: 596 SVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLK-KHK 654 Query: 211 TSHLPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRGTERVRKDLSTGC 270 H EKH + Y+ + S+ E R D + N +DL Sbjct: 655 LKHKEREKEKHKKEIEGEKEKYKTKD-SAKELQRSVEFDREFWKENFFKSDETEDLFLNM 713 Query: 271 GDGEPRILEASQRLQGH-------PEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWE 323 + E LE +L+ + EK+ E + + K K S+ ++ E+I Sbjct: 714 -EHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKI----- 767 Query: 324 KETPGERSHSRVDSQSD------------------------KKLERQSERSQNINRKEVK 359 K+ ER + D S+ +K E+ + S+ K + Sbjct: 768 KDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQ 827 Query: 360 SQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSK-------NEITFSHNSSKYHLEERR 412 ++K+ K+++K K H +SE+ L S+ + +SH++ K H E + Sbjct: 828 IKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEK 887 Query: 413 GWEDC----------KRDKSVNSHSFQDGRCPSSLSNSRT-------HKNIDSKEVDAMH 455 R+K H + L+ S+ +K D+ E Sbjct: 888 SKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSE 947 Query: 456 QWENTPLKAERHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQN 515 + +N E + E R +E + ++HI+ EK+ K E + + K Sbjct: 948 KGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDE 1007 Query: 516 EPKTDKGEVLDNGVSEGADNKELAMKAESGPNETK---NKDLKLSFMKKLNLTLSPAKKQ 572 KT G+ D +K++ E ++ K N LKL K K Sbjct: 1008 PLKTPDGKEKDK------KDKDIDRYKERDKHKDKIQINSLLKL----KSEADKPKPKSS 1057 Query: 573 PVSQDNQHK 581 P S+D + K Sbjct: 1058 PASKDTRPK 1066 Score = 38.9 bits (89), Expect = 0.051 Identities = 82/391 (20%), Positives = 153/391 (39%), Gaps = 72/391 (18%) Query: 900 KSQSDLNKENQKPIYKSDKCT------EADTCKNSPLDELE------EGEIRSDSETSKP 947 KS + + E+ P +++ CT E T K L E + EI + E K Sbjct: 619 KSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKT 678 Query: 948 QESFEKNSKRRVSAD---------------------VRKSKTIPRRGK--STVCLDKDSR 984 ++S K +R V D +S T+ ++ K + DK ++ Sbjct: 679 KDS-AKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTK 737 Query: 985 KTHV----RIHQTNNKWNKRPDKSSRSSKTEK-----------KDKVMSTSSLEKIVPII 1029 + HV + +K K +KS R K + KD ++ + I I Sbjct: 738 EKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESI 797 Query: 1030 AVPSSEQEIMHMLRMIRKHVRKNYMKFKAKFSLIQFHRIIESAILSFTSLIKHLNLHKIS 1089 + E+EI + KH++++ K K S I+ I + +F K + HK Sbjct: 798 GLHLVEKEID--IEKQEKHIKESKEK-PEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSE 854 Query: 1090 KSVTTLQKNLCDIIESKLKQVKKNGIVDRLFEQQLPDMKKKLWKFVDDQ---LDYLFAKL 1146 K L + + D I+ K K + ++ ++ K DD+ + + K Sbjct: 855 KDKLDLSECV-DKIKEKDKLYSHH--TEKCHKEGEKSKNTAAIKKTDDREKSREKMDRKH 911 Query: 1147 KKILVCDSKSFGRDSDEGKLEKTSKQ--NAQYSNSQKRSVDNSNRELLKEKLSKSEDPVH 1204 K + ++ +EK +KQ N++YS S+K +REL K++ S+ ++ ++ Sbjct: 912 DKEKPEKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESIN 971 Query: 1205 YKSLVGCKKSEENYQDQNNSSI---NTVKHD 1232 + ++ Q++ SSI N +H+ Sbjct: 972 I-------TNSKHIQEEKKSSIVDGNKAQHE 995 Score = 34.7 bits (78), Expect = 0.95 Identities = 90/490 (18%), Positives = 184/490 (37%), Gaps = 76/490 (15%) Query: 125 EINRK--DEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHRAK 182 EIN+ D I QR P H A+ K KS+ K Sbjct: 370 EINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSK--------------K 415 Query: 183 SDVSKDVHHSTSLPNLEK-EGKPHSDKRS----TSHLPTSVEKHCTNGVWSRSHYQVGEG 237 S+ ++ ST + E + K S S TS+ +K V S H Q G+ Sbjct: 416 QKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEY---VVSGEHKQKGKV 472 Query: 238 S---SNEDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKG 294 N++ + ++++ + + R+ +L+ G L+ S++ + Sbjct: 473 KRKLKNQNKNKENQELKQEKEGKENTRIT-NLTVNTG------LDCSEKTREEGNFRKSF 525 Query: 295 EPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRV---DSQSDKKLERQSERSQ 351 PK ++ F ++ K S ++ TP ++ H++ S+ L+ R Sbjct: 526 SPKDDTSLHLFHISTGKSPK-HSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRYD 584 Query: 352 NINR---------KEVKSQDKEERKVD------QKPKSVVKDQDH----------WRRSE 386 N K K ++K + + D +K + +KD+DH ++ + Sbjct: 585 NTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMD 644 Query: 387 RASLPHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNI 446 + K+++ + H +E G ++ + K + K+ Sbjct: 645 KEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSD 704 Query: 447 DSKEVDAMHQWENTPL----KAERHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNK 502 +++++ + E+ L K E++ +DK +E+ +E R+ + E+ + +K+ + Sbjct: 705 ETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKE-RNFKEERDKIKKESEKSFR 763 Query: 503 ETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADN-------KELAM-KAESGPNETKNKDL 554 E K +++N P E G+S ++ KE+ + K E E+K K Sbjct: 764 EEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPE 823 Query: 555 KLSFMKKLNL 564 K S +K+ ++ Sbjct: 824 KRSQIKEKDI 833 >gi|116089325 splicing factor, arginine/serine-rich 12 isoform a [Homo sapiens] Length = 624 Score = 70.1 bits (170), Expect = 2e-11 Identities = 82/384 (21%), Positives = 164/384 (42%), Gaps = 33/384 (8%) Query: 165 KSRSPHLDDCSKTDHRAKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPT---SVEKH 221 ++ + L++ K A+S +S + + N K G+ S RS S + S K Sbjct: 269 QAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKR 328 Query: 222 CTNGVWSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEAS 281 + SRSH + S +D RR + H + ++ ER + + D E Sbjct: 329 SQSKHRSRSHNR--SRSRQKDRRRSKSP--HKKRSKSRERRKSRSRSHSRDKRKDTREKI 384 Query: 282 QRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDK 341 + + EK + E + E + K K +G+ + E+E E+ D + D+ Sbjct: 385 KEKERVKEKDREKEREREKEREKEKE------RGKNKDRDKEREKDREK-----DKEKDR 433 Query: 342 KLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSH 401 + ER+ E ++ ++++ K QDKE+ + + K + D+ + + + P S N S Sbjct: 434 EREREKEHEKDRDKEKEKEQDKEKEREKDRSKEI--DEKRKKDKKSRTPPRSYNASRRSR 491 Query: 402 NSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTP 461 +SS+ RR + ++ + + R PS S ++ K + KE D + + Sbjct: 492 SSSRER-RRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKRE-KERDHISE----- 544 Query: 462 LKAERHRTEDKRKREQESKEENRHIRNEKRVPT-EHLQKTNKETKKTTTDLKKQNEPKTD 520 + ER R+ RK + + + +N + EH ++ + K D ++ P+T+ Sbjct: 545 -RRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDD---KDAPRTE 600 Query: 521 KGEVLDNGVSEGADNKELAMKAES 544 + ++ NG + + + L+ K E+ Sbjct: 601 ENKIQHNGNCQ-LNEENLSTKTEA 623 Score = 61.2 bits (147), Expect = 1e-08 Identities = 62/297 (20%), Positives = 123/297 (41%), Gaps = 14/297 (4%) Query: 260 ERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERIN 319 +RVR+ S EP ++++R G + + + ++ SKS + S S ++ N Sbjct: 280 KRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHN 339 Query: 320 SSWEKETPGERSHSRVDSQSDKKLERQSERSQNIN---RKEVKSQDKEERKVDQKPKSVV 376 S ++ RS S +S K ER+ RS++ + RK+ + + KE+ +V +K + Sbjct: 340 RSRSRQKDRRRSKSPHKKRS-KSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKE 398 Query: 377 KDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSS 436 ++++ R E+ KN+ + + E+ +D +R++ +D Sbjct: 399 REREKEREKEK---ERGKNK---DRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKE 452 Query: 437 LSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESKEENRHIRNEKRVPTEH 496 + + SKE+D + + R +R R + R R+ R P Sbjct: 453 QDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSP--R 510 Query: 497 LQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGAD-NKELAMKAESGPNETKNK 552 KT K + + +N+ K K E + +SE + + +M+ S + K K Sbjct: 511 TSKTIKRKSSRSPSPRSRNK-KDKKREKERDHISERRERERSTSMRKSSNDRDGKEK 566 Score = 32.3 bits (72), Expect = 4.7 Identities = 18/79 (22%), Positives = 34/79 (43%) Query: 1808 KKDELKSEPGSNCDNSELPGTLHNSHKKRRNISDLNHPHKKQRKETDLTNKEKTKKPTQD 1867 K+ E + E G N D + K++ + H+K R + ++K K+ +D Sbjct: 403 KEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKD 462 Query: 1868 SCENTEAHQKKASKKKAPP 1886 + + +KK K + PP Sbjct: 463 RSKEIDEKRKKDKKSRTPP 481 Score = 31.6 bits (70), Expect = 8.1 Identities = 26/115 (22%), Positives = 52/115 (45%), Gaps = 4/115 (3%) Query: 906 NKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKNSKRRVSADVRK 965 NK+ K + +K E D K+ + +E E D E K Q+ ++ K R S ++ + Sbjct: 414 NKDRDK---EREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDR-SKEIDE 469 Query: 966 SKTIPRRGKSTVCLDKDSRKTHVRIHQTNNKWNKRPDKSSRSSKTEKKDKVMSTS 1020 + ++ ++ SR++ + + ++ +S R+SKT K+ S S Sbjct: 470 KRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPS 524 >gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [Homo sapiens] Length = 508 Score = 70.1 bits (170), Expect = 2e-11 Identities = 82/384 (21%), Positives = 164/384 (42%), Gaps = 33/384 (8%) Query: 165 KSRSPHLDDCSKTDHRAKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPT---SVEKH 221 ++ + L++ K A+S +S + + N K G+ S RS S + S K Sbjct: 153 QAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKR 212 Query: 222 CTNGVWSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEAS 281 + SRSH + S +D RR + H + ++ ER + + D E Sbjct: 213 SQSKHRSRSHNR--SRSRQKDRRRSKSP--HKKRSKSRERRKSRSRSHSRDKRKDTREKI 268 Query: 282 QRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDK 341 + + EK + E + E + K K +G+ + E+E E+ D + D+ Sbjct: 269 KEKERVKEKDREKEREREKEREKEKE------RGKNKDRDKEREKDREK-----DKEKDR 317 Query: 342 KLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSH 401 + ER+ E ++ ++++ K QDKE+ + + K + D+ + + + P S N S Sbjct: 318 EREREKEHEKDRDKEKEKEQDKEKEREKDRSKEI--DEKRKKDKKSRTPPRSYNASRRSR 375 Query: 402 NSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTP 461 +SS+ RR + ++ + + R PS S ++ K + KE D + + Sbjct: 376 SSSRER-RRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKRE-KERDHISE----- 428 Query: 462 LKAERHRTEDKRKREQESKEENRHIRNEKRVPT-EHLQKTNKETKKTTTDLKKQNEPKTD 520 + ER R+ RK + + + +N + EH ++ + K D ++ P+T+ Sbjct: 429 -RRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDD---KDAPRTE 484 Query: 521 KGEVLDNGVSEGADNKELAMKAES 544 + ++ NG + + + L+ K E+ Sbjct: 485 ENKIQHNGNCQ-LNEENLSTKTEA 507 Score = 61.2 bits (147), Expect = 1e-08 Identities = 62/297 (20%), Positives = 123/297 (41%), Gaps = 14/297 (4%) Query: 260 ERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERIN 319 +RVR+ S EP ++++R G + + + ++ SKS + S S ++ N Sbjct: 164 KRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHN 223 Query: 320 SSWEKETPGERSHSRVDSQSDKKLERQSERSQNIN---RKEVKSQDKEERKVDQKPKSVV 376 S ++ RS S +S K ER+ RS++ + RK+ + + KE+ +V +K + Sbjct: 224 RSRSRQKDRRRSKSPHKKRS-KSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKE 282 Query: 377 KDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSS 436 ++++ R E+ KN+ + + E+ +D +R++ +D Sbjct: 283 REREKEREKEK---ERGKNK---DRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKE 336 Query: 437 LSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESKEENRHIRNEKRVPTEH 496 + + SKE+D + + R +R R + R R+ R P Sbjct: 337 QDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSP--R 394 Query: 497 LQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGAD-NKELAMKAESGPNETKNK 552 KT K + + +N+ K K E + +SE + + +M+ S + K K Sbjct: 395 TSKTIKRKSSRSPSPRSRNK-KDKKREKERDHISERRERERSTSMRKSSNDRDGKEK 450 Score = 32.3 bits (72), Expect = 4.7 Identities = 18/79 (22%), Positives = 34/79 (43%) Query: 1808 KKDELKSEPGSNCDNSELPGTLHNSHKKRRNISDLNHPHKKQRKETDLTNKEKTKKPTQD 1867 K+ E + E G N D + K++ + H+K R + ++K K+ +D Sbjct: 287 KEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKD 346 Query: 1868 SCENTEAHQKKASKKKAPP 1886 + + +KK K + PP Sbjct: 347 RSKEIDEKRKKDKKSRTPP 365 Score = 31.6 bits (70), Expect = 8.1 Identities = 26/115 (22%), Positives = 52/115 (45%), Gaps = 4/115 (3%) Query: 906 NKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKNSKRRVSADVRK 965 NK+ K + +K E D K+ + +E E D E K Q+ ++ K R S ++ + Sbjct: 298 NKDRDK---EREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDR-SKEIDE 353 Query: 966 SKTIPRRGKSTVCLDKDSRKTHVRIHQTNNKWNKRPDKSSRSSKTEKKDKVMSTS 1020 + ++ ++ SR++ + + ++ +S R+SKT K+ S S Sbjct: 354 KRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPS 408 >gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens] Length = 494 Score = 62.4 bits (150), Expect = 4e-09 Identities = 72/342 (21%), Positives = 140/342 (40%), Gaps = 40/342 (11%) Query: 242 DSRRGRKD------IRHSQFNRGTERVRKDLSTGCGDGEPRILE---ASQRLQGHPEKYG 292 D+ +GRK+ + +S R E++ T + R++E S+R + + Sbjct: 134 DAHKGRKNEGVIEFVSYSDMKRALEKLD---GTEVNGRKIRLVEDKPGSRRRRSYSRSRS 190 Query: 293 KGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQN 352 ++ S+ S+ KS S S + S + G RS S+ S+S + + E+S++ Sbjct: 191 HSRSRSRSRHSR-KSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRSRSQSRSRSKKEKSRS 249 Query: 353 INRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERR 412 ++++ +S+ K K K +++ + ++ P S++ S + R Sbjct: 250 PSKEKSRSRSHSAGKSRSKSKDQAEEKI--QNNDNVGKPKSRSPSRHKSKSKSRSRSQER 307 Query: 413 GWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDK 472 E+ KR SV+ Q+ S S SR+ S+ R +++DK Sbjct: 308 RVEEEKRG-SVSRGRSQEKSLRQSRSRSRSKGGSRSRS-------------RSRSKSKDK 353 Query: 473 RKREQESKEENRHIRNEKRVPTEHLQK----------TNKETKKTTTDLKKQNEPKTDKG 522 RK + S+EE+R R+ R +E +K ++K+ KK TD + P Sbjct: 354 RKGRKRSREESRS-RSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVS 412 Query: 523 EVLDNGVSEGADNKELAMKAESGPNETKNKDLKLSFMKKLNL 564 + ++ SE + + +G N+ + + K NL Sbjct: 413 KEREHAKSESSQREGRGESENAGTNQETRSRSRSNSKSKPNL 454 Score = 45.8 bits (107), Expect = 4e-04 Identities = 62/269 (23%), Positives = 104/269 (38%), Gaps = 47/269 (17%) Query: 153 ARTFDTVKTKDLKSRSPHLDDCSKTDHRAKSDVSKDVHHSTS-LPNLEKEGKPHS----- 206 +R+ ++K KSRSP + H A SK + + N + GKP S Sbjct: 234 SRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSPSR 293 Query: 207 ------------------DKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGS------SNED 242 +KR + S EK SRS + G S ++D Sbjct: 294 HKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSR-SRSRSKGGSRSRSRSRSKSKD 352 Query: 243 SRRGRKDIRHSQFNRGTERVRKDLS--------TGCGDGEPRILEASQRLQGHPEKYGKG 294 R+GRK R +R R + + S + G + + E + R Q Sbjct: 353 KRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVS 412 Query: 295 EPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNIN 354 + + +KS +S + +GE N+ +ET RS SR +S+S L +S RS++ + Sbjct: 413 KEREHAKS----ESSQREGRGESENAGTNQET---RSRSRSNSKSKPNLPSES-RSRSKS 464 Query: 355 RKEVKSQDKEERKVDQKPKSVVKDQDHWR 383 + +S+ K + + S + + H R Sbjct: 465 ASKTRSRSKSRSRSASRSPSRSRSRSHSR 493 Score = 32.3 bits (72), Expect = 4.7 Identities = 33/138 (23%), Positives = 55/138 (39%), Gaps = 10/138 (7%) Query: 895 AHSTSKSQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKN 954 +HS KS+S + ++ I +D + + SP + + RS S+ + +E + Sbjct: 259 SHSAGKSRSKSKDQAEEKIQNNDNVGKPKS--RSPSRHKSKSKSRSRSQERRVEEEKRGS 316 Query: 955 SKR--------RVSADVRKSKTIPRRGKSTVCLDKDSRKTHVRIHQTNNKWNKRPDKSSR 1006 R R S +SK R + KD RK R + + ++ KS R Sbjct: 317 VSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSER 376 Query: 1007 SSKTEKKDKVMSTSSLEK 1024 S K K + SS +K Sbjct: 377 SRKRGSKRDSKAGSSKKK 394 >gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain containing B [Homo sapiens] Length = 546 Score = 62.4 bits (150), Expect = 4e-09 Identities = 79/351 (22%), Positives = 136/351 (38%), Gaps = 39/351 (11%) Query: 214 LPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDG 273 +P V+K+ + +R +D + G ++I R + R+ LS Sbjct: 221 IPVPVQKNIDQQIKTRPR------KIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPR 274 Query: 274 EPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHS 333 R S +GH E + E + + + + K R + S ++ RS S Sbjct: 275 RSR--SRSHHREGHGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRS 332 Query: 334 RVDSQSDKKLERQSERSQNINRK-EVKSQDKEERKVDQKPKSVVKDQDHWRRSER----- 387 R ER RS++ +RK + + +D+E K +++ + +D D R +ER Sbjct: 333 R---------ERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERE 383 Query: 388 ASLPHSKNEITFSHNSSKYHLEER--RGWEDCKRD-KSVNSHSFQDGRCPSSLSNSRTHK 444 S SK + + K H E++ R D KRD K HS S S R H+ Sbjct: 384 RSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHS-------RSRSRERKHR 436 Query: 445 NIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESK--EENRHIRNEKRVPTEHLQKTNK 502 + + K+ +H+ E K K + S+ + R EK EH K Sbjct: 437 SRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEK 496 Query: 503 ETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAMKAESGPNETKNKD 553 K++ + K+ K D + D + + +++ ES + KNKD Sbjct: 497 SRKRSRS---KERSHKRDHSDSKDQS-DKHDRRRSQSIEQESQEKQHKNKD 543 Score = 55.8 bits (133), Expect = 4e-07 Identities = 57/273 (20%), Positives = 107/273 (39%), Gaps = 17/273 (6%) Query: 228 SRSHYQVGEGSSNEDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDG--EPRILEASQRLQ 285 SRSH++ G GSS+ D R+ R ER ++ + D E R + +R + Sbjct: 278 SRSHHREGHGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHR 337 Query: 286 GHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLER 345 + + + + K N +G R + ++KE ER R +S ++ + Sbjct: 338 SRSRSRDRKGDRRDRDREREKENE----RGRRRDRDYDKERGNEREKER--ERSRERSKE 391 Query: 346 QSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSK 405 Q R + +K + +D + D++ K R ER S++ + S+ Sbjct: 392 QRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSR 451 Query: 406 YHLEERRGWEDCKRDKSVNSHSFQDGRCPS---------SLSNSRTHKNIDSKEVDAMHQ 456 + + + K + S S GR S S S ++ K SKE Sbjct: 452 SKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRD 511 Query: 457 WENTPLKAERHRTEDKRKREQESKEENRHIRNE 489 ++ ++++H + EQES+E+ ++E Sbjct: 512 HSDSKDQSDKHDRRRSQSIEQESQEKQHKNKDE 544 Score = 34.7 bits (78), Expect = 0.95 Identities = 48/232 (20%), Positives = 93/232 (40%), Gaps = 28/232 (12%) Query: 334 RVDSQSDKKLERQSE-RSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPH 392 R+ K +++Q + R + I + + ++ +R V+++ + RRS R S Sbjct: 220 RIPVPVQKNIDQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRS--R 277 Query: 393 SKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVD 452 S++ H SS + E R E + ++ ++ R S+ + S+E Sbjct: 278 SRSHHREGHGSSSFDRELEREKERQRLEREAKERE-KERRRSRSIDRGLERRRSRSRE-- 334 Query: 453 AMHQWENTPLKAERHRTEDKRKREQESKEENRHIR-----------NEKRVPTEHLQKTN 501 + R R D+R R++E ++EN R NE+ E ++ + Sbjct: 335 -----RHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERS 389 Query: 502 KETK-KTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAMKAESGPNETKNK 552 KE + + + KK E K D+ D D+K+ + S E K++ Sbjct: 390 KEQRSRGEVEEKKHKEDKDDRRHRDDK-----RDSKKEKKHSRSRSRERKHR 436 Score = 33.9 bits (76), Expect = 1.6 Identities = 60/335 (17%), Positives = 124/335 (37%), Gaps = 32/335 (9%) Query: 23 KNNDEGSLDIYAGLDSAVSDSASKSCVPSRNCLDLYEEILTEEGTAKEATYNDLQVEYGK 82 K+ EG+ +I ++ S S +S P R+ EG + +L+ E + Sbjct: 242 KDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKER 301 Query: 83 CQLQMKELMKKFKEIQTQNFSLINENQSLKKNISALIKTARVEINRKDEEISNLHQRLSE 142 +L+ ++ KE + + + ++ L++ S + R +D + + Sbjct: 302 QRLE-----REAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDRER 356 Query: 143 FPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHRAKSDVSKDVHHSTSLPNLEKEG 202 + R +D + + + + SK + R++ +V + H +K+ Sbjct: 357 EKENERGRRRDRDYDKERGNEREKERERSRERSK-EQRSRGEVEEKKHKE------DKDD 409 Query: 203 KPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRGTERV 262 + H D + S + + RS + SR K +H N E+ Sbjct: 410 RRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHK--NESKEKS 467 Query: 263 RKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSW 322 K +G G +E S++ + P K + + S + +SDS + ++ Sbjct: 468 NKRSRSG-SQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDK----- 521 Query: 323 EKETPGERSHSRVDSQSDKKLERQSERSQNINRKE 357 H R SQS +E++S+ Q+ N+ E Sbjct: 522 ---------HDRRRSQS---IEQESQEKQHKNKDE 544 >gi|42560244 peptidylprolyl isomerase G [Homo sapiens] Length = 754 Score = 62.0 bits (149), Expect = 6e-09 Identities = 92/397 (23%), Positives = 161/397 (40%), Gaps = 66/397 (16%) Query: 112 KKNISALIKTARVEINRKDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHL 171 K ++ + + R + K+ +I++ H+ +SE P+ +N + K KD KS S Sbjct: 385 KSELNEIKENQRSPVRVKERKITD-HRNVSESPNRKNEKEK-------KVKDHKSNSKER 436 Query: 172 D--DCSKTDHRAKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSR 229 D S+ D + K+ V K + S + + K S +R + H + EK + R Sbjct: 437 DIRRNSEKDDKYKNKVKK---RAKSKSRSKSKEKSKSKERDSKH-NRNEEKRMRSRSKGR 492 Query: 230 SHYQVGEGSSNEDSR-----RGRKDIRHSQFN----------------RGTERVRK-DLS 267 H V E DS+ R R + Q R R R+ D++ Sbjct: 493 DHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSRECDIT 552 Query: 268 TGCGDGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETP 327 G R E S+ + + S+S ++ + +Y+ + S E+ TP Sbjct: 553 KGKHSYNSRTRERSRSRDRSRRVRSRTHDRDRSRSKEYHRYREQEYRRRGRSRSRERRTP 612 Query: 328 GERSHSRVDSQSDKKLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSER 387 RS S+ D + ++ R SER ++ +R + K +++E + +K S SE+ Sbjct: 613 PGRSRSK-DRRRRRRDSRSSEREESQSRNKDKYRNQESKSSHRKENS---------ESEK 662 Query: 388 ASLPHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNS---HSFQDGRCPSSLSNSRTHK 444 S++ HNSS E++ RD+S S S QD SS+ K Sbjct: 663 RMYSKSRD-----HNSSNNSREKK-----ADRDQSPFSKIKQSSQDNELKSSML-----K 707 Query: 445 NIDSKEVDAMHQWENTPLKAER--HRTEDKRKREQES 479 N + +++ + + EN K + H E +K + ES Sbjct: 708 NKEDEKIRSSVEKENQKSKGQENDHVHEKNKKFDHES 744 Score = 60.8 bits (146), Expect = 1e-08 Identities = 76/315 (24%), Positives = 136/315 (43%), Gaps = 31/315 (9%) Query: 276 RILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRV 335 R + S + EK K + K+ SK + NS+ D K + N ++ RS S+ Sbjct: 410 RNVSESPNRKNEKEKKVK-DHKSNSKERDIRRNSEKDDKYK--NKVKKRAKSKSRSKSKE 466 Query: 336 DSQSDKKLERQSERSQNINRKEVKSQDKEERKVDQKPK-SVVKDQDHWRRSERASLPHSK 394 S+S ++ + + + R K +D E K +K S KDQ+ R E++ SK Sbjct: 467 KSKSKERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESK 526 Query: 395 NEITFSHNSSKYHLEERRGWEDCKR-DKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDA 453 + H+ SK ++RR + D + HS+ NSRT + S+ D Sbjct: 527 SN---EHDHSKSKEKDRRAQSRSRECDITKGKHSY----------NSRTRER--SRSRDR 571 Query: 454 MHQWENTPLKAERHRTED-KRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLK 512 + + +R R+++ R REQE + R E+R P + ++ ++ + Sbjct: 572 SRRVRSRTHDRDRSRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSS 631 Query: 513 KQNEPKTDKGEVLDNGVSEGADNKELA-----MKAESGPNETKNKDLKLSFMKKLNLTLS 567 ++ E ++ + N S+ + KE + M ++S + + N S KK + S Sbjct: 632 EREESQSRNKDKYRNQESKSSHRKENSESEKRMYSKSRDHNSSNN----SREKKADRDQS 687 Query: 568 P-AKKQPVSQDNQHK 581 P +K + SQDN+ K Sbjct: 688 PFSKIKQSSQDNELK 702 Score = 48.5 bits (114), Expect = 6e-05 Identities = 79/384 (20%), Positives = 160/384 (41%), Gaps = 43/384 (11%) Query: 199 EKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRG 258 ++E K H K S+S +S + ++ S S E ++ E S++ +K R + Sbjct: 185 KEEKKRH--KSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHRKNSRKHK 242 Query: 259 TERVRKDLS--TGCGDGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGE 316 E+ ++ S + + E LEA + PE+ P E++ KS +D K E Sbjct: 243 KEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEI---PPIPENRFLMRKSPPKADEK-E 298 Query: 317 RINSSWEKET--------PGERSHSRVDSQSDKKLE-------RQSERSQN---INRKEV 358 R N E+E P + ++S +K++ R RS++ R E Sbjct: 299 RKNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTPSRSRSRDRFRRSET 358 Query: 359 KSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCK 418 ++E + Q+ + V + W + +++ L NEI + S ++ER+ + Sbjct: 359 PPHWRQEMQRAQRMR--VSSGERWIKGDKSEL----NEIK-ENQRSPVRVKERKITDHRN 411 Query: 419 RDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQE 478 +S N + ++ + SNS+ + E D ++ + + R++ K K + + Sbjct: 412 VSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSK 471 Query: 479 SKEENRHIRNEKRVPT-----EHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSE-- 531 ++ + EKR+ + +H KE + + ++ +K + L++ +E Sbjct: 472 ERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHD 531 Query: 532 GADNKELAMKAESGPNE---TKNK 552 + +KE +A+S E TK K Sbjct: 532 HSKSKEKDRRAQSRSRECDITKGK 555 Score = 44.3 bits (103), Expect = 0.001 Identities = 63/296 (21%), Positives = 121/296 (40%), Gaps = 38/296 (12%) Query: 274 EPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHS 333 E RIL + + P+ K E K KSS S+S SD ++ + S Sbjct: 168 EVRILSCGELI---PKSKVKKEEKKRHKSSSSSSSSSSD-----------SDSSSDSQSS 213 Query: 334 RVDSQSDKKLERQSERSQNINRKEVKSQDKEERKVDQKPKSV----------VKDQDHWR 383 S S+ E +S++ + +RK + KE++K + KS + Q R Sbjct: 214 SDSSDSESATEEKSKKRKKKHRKNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVR 273 Query: 384 RSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTH 443 E +P +N + K +ER+ E +R++ N + Q L +R+ Sbjct: 274 PEEIPPIP--ENRFLMRKSPPKADEKERKNRER-ERERECNPPNSQPASYQRRLLVTRSG 330 Query: 444 KNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNKE 503 + I + + TP R R+ D+ +R + + ++ +R+ ++ K Sbjct: 331 RKIKGRG----PRRYRTP---SRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKG 383 Query: 504 TKKTTTDLKK-QNEP-KTDKGEVLDN-GVSEGADNK-ELAMKAESGPNETKNKDLK 555 K ++K+ Q P + + ++ D+ VSE + K E K + + +K +D++ Sbjct: 384 DKSELNEIKENQRSPVRVKERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIR 439 Score = 40.4 bits (93), Expect = 0.017 Identities = 76/393 (19%), Positives = 148/393 (37%), Gaps = 37/393 (9%) Query: 907 KENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKNSK-RRVSADVRK 965 K+ +K +KS + + + + + + SDSE++ ++S ++ K R+ S +K Sbjct: 184 KKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHRKNSRKHKK 243 Query: 966 SKTIPRRGKSTVCLDKDSRKTHVRIHQTNNKWNKRPDKSSR-------SSKTEKKDKVMS 1018 K ++ K + + ++ + T P +R EK+ K Sbjct: 244 EKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPENRFLMRKSPPKADEKERKNRE 303 Query: 1019 TSSLEKIVPIIAVPSSEQEIMHMLRMIRKHVRKNYMKFKAKFSLIQFHRIIESAI-LSFT 1077 + P + P+S Q + + R RK + +++ R S + Sbjct: 304 RERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTPSRSRSRDRFRRSETPPHWR 363 Query: 1078 SLIKHLNLHKISKSVTTLQKNLCDIIESKLKQ-----VKKNGIVDRLFEQQLPDMKKKLW 1132 ++ ++S ++ + ++ E K Q VK+ I D + P+ K + Sbjct: 364 QEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERKITDHRNVSESPNRKNE-- 421 Query: 1133 KFVDDQLDYLFAKLKKILVCDSKSFGRDSDEGKLEKTSKQNAQYSNSQKRSVDNSNRELL 1192 K KK+ K +S E + + S+++ +Y N K+ + +R Sbjct: 422 ------------KEKKV-----KDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKS 464 Query: 1193 KEK-LSKSEDPVHYKSLVGCKKSEENYQDQNNSSINTVKHDIK-KNFNICFDNIKNSQSE 1250 KEK SK D H ++ +S +D N + D K K+ K+ Q E Sbjct: 465 KEKSKSKERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLE 524 Query: 1251 ERSLE-VHCPSTPKSEKNEGSSIE-DAQTSQHA 1281 +S E H S K + + S E D +H+ Sbjct: 525 SKSNEHDHSKSKEKDRRAQSRSRECDITKGKHS 557 Score = 37.4 bits (85), Expect = 0.15 Identities = 33/161 (20%), Positives = 61/161 (37%), Gaps = 19/161 (11%) Query: 1739 DLTQDASSEAKSEGNHPALAVEDLGCGVIQVDEDNCKEEKAQVANRPLKCIVEETYIDLT 1798 ++ ++ ++ + P V L CG + KEEK + + Sbjct: 149 EVVREIENQKTDAASKPFAEVRILSCGELIPKSKVKKEEKKRHKS--------------- 193 Query: 1799 TESPSSCEVKKDELKSEPGSNCDNSELPGTLHNSHKKRRNISDLNHPHKKQRKETDLTNK 1858 S SS + S+ S+ D+S+ KKR+ N +K +KE K Sbjct: 194 -SSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHRKNS--RKHKKEKKKRKK 250 Query: 1859 EKTKKPTQDSCENTEAH-QKKASKKKAPPVTKDPSSLKATP 1898 K ++ EN EA Q ++ PP+ ++ ++ +P Sbjct: 251 SKKSASSESEAENLEAQPQSTVRPEEIPPIPENRFLMRKSP 291 >gi|87299628 biorientation of chromosomes in cell division 1-like [Homo sapiens] Length = 3051 Score = 61.6 bits (148), Expect = 7e-09 Identities = 222/1119 (19%), Positives = 401/1119 (35%), Gaps = 180/1119 (16%) Query: 77 QVEYGKCQLQMKELMKKFKEIQT--QNFSLINENQSLKKNISALIKTARVEINRKDEEIS 134 Q+ K + + K+ +K K +T Q S ++ +S K++ K AR++ K+ ++ Sbjct: 509 QINREKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEP--KAARIKEVLKERKVL 566 Query: 135 NLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHRAKSDVSKDVHHSTS 194 LS + K +R + K + + ++H K +S S Sbjct: 567 EKKVALS-----KKRKKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISS----SKE 617 Query: 195 LPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQ------VGEGSSNE-DSRRGR 247 L ++ + +P R S V+++ R H + + EG E D+R + Sbjct: 618 LKHVHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRRTSTPVIMEGVQEETDTRDVK 677 Query: 248 KDIRHSQFNRGTERVRKDLSTGCGDGEPRILEAS----QRLQGHPEKYGKGEPKTESKSS 303 + + S+ TE +K ST + + ++ + L K K +P+ E S Sbjct: 678 RQVERSEIC--TEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPEREKTPS 735 Query: 304 KFKSNSDSDYKGERINSSWEK----------------ETPGERSHSRVDSQSDKKLERQS 347 + K + YKG+ ++ + ++ + +++ D ++++K + ++ Sbjct: 736 EDKLSVKHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQQTKLSSDDKTERKSKHRN 795 Query: 348 ERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYH 407 ER ++ K+ K + K D+ + +++ ++ R S +K E +S Sbjct: 796 ERKLSVLGKDGKPVSEYIIKTDENVR-----KENNKKERRLSAEKTKAEHKSRRSSDSKI 850 Query: 408 LEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERH 467 ++ G + S S+ + +C + ++ N+ +EV + L E+ Sbjct: 851 QKDSLGSKQHGITLQRRSESYSEDKC--DMDSTNMDSNLKPEEVVHKEKRRTKSLLEEKL 908 Query: 468 RTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDN 527 + K K + + + E K +KE D +KQ + K + + Sbjct: 909 VLKSKSKTQGKQVKVVETELQEGATKQATTPKPDKEKNTEENDSEKQRKSKVEDKPFEET 968 Query: 528 GVSEGADNKELAMKAESGPNETKNKDLKLSFMKKLNLTLSPAK--KQPVSQDNQHKITDI 585 GV E ++ S + KD S KL L K K S + K++D Sbjct: 969 GV-------EPVLETASSSAHSTQKD--SSHRAKLPLAKEKYKSDKDSTSTRLERKLSDG 1019 Query: 586 PKSSGVCDSESSMQVKTVAYVPSISEHILGEAAVSEHTMGETKSTLLEPKVALLAVTEPR 645 KS + S ++ K + S+ G+ S H S+L+E K++ R Sbjct: 1020 HKSRSLKHSSKDIKKKD----ENKSDDKDGKEVDSSHEKARGNSSLMEKKLSRRLCENRR 1075 Query: 646 IGISETNKEDENSLLVR--SVDNTMHCEEP-ICGTETSFP--SPMEIQQ---TESLF--- 694 +S+ + E L S + + P G T P PMEI E++F Sbjct: 1076 GSLSQEMAKGEEKLAANTLSTPSGSSLQRPKKSGDMTLIPEQEPMEIDSEPGVENVFEVS 1135 Query: 695 --------------PSTGMKQTIN-------------NGRAAAPVVMDVLQTDVSQNFGL 727 S MKQ + + +A AP T V+ N Sbjct: 1136 KTQDNRNNNSQQDIDSENMKQKTSATVQKDELRTCTADSKATAPAYKPGRGTGVNSNSEK 1195 Query: 728 ELD------TKRNDNSDYCGISEGMEMKVALSTTV----SETTESILQPSIEEADILPIM 777 D K + S ++ G + + TT SET +L + E D + Sbjct: 1196 HADHRSTLTKKMHIQSAVSKMNPGEKEPIHRGTTEVNIDSETVHRMLLSAPSENDRVQKN 1255 Query: 778 LSE--------------------DNNPKFEPSVIVTPLVESKSCHLEPCLPKET-LDSSL 816 L D++P SV V PL ES + P K T L+ S Sbjct: 1256 LKNTAAEEHVAQGDATLEHSTNLDSSPSLS-SVTVVPLRESYDPDVIPLFDKRTVLEGST 1314 Query: 817 QQTELMDHRMATGETNSVYHDD---------------DNSVLSIDLNHLRPIPEA--ISP 859 T DH ++ +V + ++ + R IPEA + Sbjct: 1315 ASTSPADHSALPNQSLTVRESEVLKTSDSKEGGEGFTVDTPAKASITSKRHIPEAHQATL 1374 Query: 860 LNSPVRPVAKVLRNESPPQVPVYNNSHKDVFLPNSAHSTSKSQSDLNKE-NQKPIYKSDK 918 L+ V L ++ + N K+ L + A K ++DLN E N K K+ Sbjct: 1375 LDGKQGKVIMPLGSKLTGVIVENENITKEGGLVDMA----KKENDLNAEPNLKQTIKA-- 1428 Query: 919 CTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKNSKRRVSADVRKSKTIPRRGKSTVC 978 E +D + +ET K + + +S DV + R S V Sbjct: 1429 TVENGKKDGIAVDHVVGLNTEKYAETVKLKHKRSPGKVKDISIDVER-----RNENSEVD 1483 Query: 979 LDKDSRKTHVRIHQTNNKWN------KRPDKSSRSSKTEKKDKVM----------STSSL 1022 S +HQ N + +R +K+S ++ TE KDK + +T+S Sbjct: 1484 TSAGSGSAPSVLHQRNGQTEDVATGPRRAEKTSVATSTEGKDKDVTLSPVKAGPATTTSS 1543 Query: 1023 EKIVPIIAVPSSEQEIMHMLRMIRKHVRKNYMKFKAKFS 1061 E +A+P + E L +I H R N + A+ S Sbjct: 1544 ETRQSEVALPCTSIEADEGL-IIGTHSRNNPLHVGAEAS 1581 Score = 49.7 bits (117), Expect = 3e-05 Identities = 91/457 (19%), Positives = 175/457 (38%), Gaps = 72/457 (15%) Query: 105 INENQSLKKNISALIKTARVEINRKDEEISNLHQRLSE-FPHFRNNHKTARTFDTVKTKD 163 + + S +KN S + + N K E ++ + F H + + T + D + K+ Sbjct: 307 VQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKE 366 Query: 164 -----LKSRSPHLDDCSKTDHRAKSDVS---KDVH----------HSTSLPNLEKEGKPH 205 LK S + +KT K D S DV H++ L + E++ + Sbjct: 367 KEVESLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEE 426 Query: 206 ---SDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRRGR-KDIRHSQFNRG--- 258 SD + + E+ + Q + DS G+ K +RH+ ++ Sbjct: 427 VVTSDSMEEGEITSDDEE---------KNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLY 477 Query: 259 ------------TERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFK 306 E+ R+ ++ + E R+L + EK + KT+S +K + Sbjct: 478 SKYYSDSDDELTVEQRRQSIAK---EKEERLLRRQINREKLEEKRKQKAEKTKSSKTKGQ 534 Query: 307 SNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKSQDKEER 366 S D + E S E + + + +KK+ +R ++ + V+ K+++ Sbjct: 535 GRSSVDLE-ESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKKD--SRNVEENSKKKQ 591 Query: 367 KVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSH 426 + ++ K +K +H + + +S E+ H S+ RR S + H Sbjct: 592 QYEEDSKETLKTSEHCEKEKISS----SKELKHVHAKSEPSKPARR--------LSESLH 639 Query: 427 SFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESKEENRHI 486 + + S L R HK S V E T + + + E +E +++ + Sbjct: 640 VVDENKNESKLE--REHKRRTSTPVIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTL 697 Query: 487 RNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGE 523 +NEK HL+K + ET + LKK+ + +K E Sbjct: 698 KNEK-----HLKKDDSETPHLKSLLKKEVKSSKEKPE 729 Score = 48.1 bits (113), Expect = 8e-05 Identities = 75/387 (19%), Positives = 139/387 (35%), Gaps = 47/387 (12%) Query: 235 GEGSSNEDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKG 294 GE + + + RK + + + + +K T E + E P + Sbjct: 322 GEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEVESLKLPSEKNSN 381 Query: 295 EPKTESKSSKFKSNSDSDYKG----------ERINSSWEKETPGERSHSRVDSQSDKKLE 344 + KT + + S DSD G SS+E++T E S DS + ++ Sbjct: 382 KAKTVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTS--DSMEEGEIT 439 Query: 345 RQSERSQNINRKEVKSQDKEERKVDQKPKSVV------------KDQDHWRRSERASLPH 392 E N+ + ++ D E K + V D + R S+ Sbjct: 440 SDDEEKNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAK 499 Query: 393 SKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVD 452 K E ++ LEE+R K +K+ +S + GR L S T K+++ K Sbjct: 500 EKEERLLRRQINREKLEEKRKQ---KAEKTKSSKTKGQGRSSVDLEESST-KSLEPKAAR 555 Query: 453 AMHQWENTPLKAERHRTEDKRKREQESKEENRHIR-------NEKRVPTEHLQKTNKETK 505 + + ++ KRK++ + EEN + E +EH +K + Sbjct: 556 IKEVLKERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSS 615 Query: 506 KTTTDLKKQNEPK------TDKGEVLDNGVSEGADNKELAMKA------ESGPNETKNKD 553 K + ++EP ++ V+D +E +E + E ET +D Sbjct: 616 KELKHVHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRRTSTPVIMEGVQEETDTRD 675 Query: 554 LKLSFMKKLNLTLSPAKKQPVSQDNQH 580 +K + T P K++ ++ +H Sbjct: 676 VKRQVERSEICTEEPQKQKSTLKNEKH 702 Score = 39.3 bits (90), Expect = 0.039 Identities = 79/429 (18%), Positives = 153/429 (35%), Gaps = 68/429 (15%) Query: 61 ILTEEGTAKEATYNDLQVEYGKCQLQMKELMKKFKEIQTQNFSLINENQSLKKNISAL-- 118 I T+E KE + ++ K + + K +IQ + +L++ + Sbjct: 814 IKTDENVRKENNKKERRLSAEKTKAEHKSRRSSDSKIQKDSLGSKQHGITLQRRSESYSE 873 Query: 119 ----IKTARVEINRKDEEISNLHQR-----LSEFPHFRNNHKT-ARTFDTVKTK-----D 163 + + ++ N K EE+ + +R L E ++ KT + V+T+ Sbjct: 874 DKCDMDSTNMDSNLKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVVETELQEGAT 933 Query: 164 LKSRSPHLDDCSKTDH-----RAKSDVSKDVHHSTSL-PNLEK-EGKPHSDKRSTSH--- 213 ++ +P D T+ + KS V T + P LE HS ++ +SH Sbjct: 934 KQATTPKPDKEKNTEENDSEKQRKSKVEDKPFEETGVEPVLETASSSAHSTQKDSSHRAK 993 Query: 214 LPTSVEKHCTN--GVWSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRGTERVRKDLSTGCG 271 LP + EK+ ++ +R ++ +G + + KDI+ N+ ++ K++ + Sbjct: 994 LPLAKEKYKSDKDSTSTRLERKLSDGHKSRSLKHSSKDIKKKDENKSDDKDGKEVDSS-- 1051 Query: 272 DGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSN-----SDSDYKGERINSSWEKET 326 H + G + S + N S KGE ++ T Sbjct: 1052 ---------------HEKARGNSSLMEKKLSRRLCENRRGSLSQEMAKGEEKLAANTLST 1096 Query: 327 PGERSHSRVDSQSDKKLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSE 386 P S R D L + E + + V++ + + D + + +D D + Sbjct: 1097 PSGSSLQRPKKSGDMTLIPEQEPMEIDSEPGVENVFEVSKTQDNRNNNSQQDIDSENMKQ 1156 Query: 387 RASLPHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNI 446 + S K+E+ C D + +++ GR SNS H + Sbjct: 1157 KTSATVQKDEL-----------------RTCTADSKATAPAYKPGRGTGVNSNSEKHADH 1199 Query: 447 DSKEVDAMH 455 S MH Sbjct: 1200 RSTLTKKMH 1208 Score = 31.6 bits (70), Expect = 8.1 Identities = 52/248 (20%), Positives = 97/248 (39%), Gaps = 20/248 (8%) Query: 278 LEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDS 337 +E +QR E + E + K++S+++ R+ ++ + E + + + Sbjct: 2795 IETAQRQCPETEPHDTKEENSRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTGEKPEQ 2854 Query: 338 QSDKKLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQ---DHWRRSERASLPHSK 394 D ++ Q E I +K + RK + +KD D + S SK Sbjct: 2855 NDDDTIKSQEEDQPII----IKRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSPSSSK 2910 Query: 395 NEITFSHNSSKY--HLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVD 452 ++ + S+K +L+ER D +K V S + + SL+ S + +S E + Sbjct: 2911 LKVMQTDESNKETANLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVS---DDAESSEPE 2967 Query: 453 AMHQWENTPLKAERHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLK 512 Q K+ EDK+ EQES EE ++ T E +++ T L Sbjct: 2968 RKRQ------KSVSDPVEDKK--EQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQLS 3019 Query: 513 KQNEPKTD 520 + K + Sbjct: 3020 PSIKRKRE 3027 >gi|82830424 gon-4-like isoform a [Homo sapiens] Length = 2240 Score = 61.6 bits (148), Expect = 7e-09 Identities = 47/145 (32%), Positives = 75/145 (51%), Gaps = 8/145 (5%) Query: 1836 RRNISDLNHPHKKQRKETDLTNKEKTKKPTQDSCENTEAHQKKASKKKAPP--VTKDPSS 1893 RR++S P ++R + KT+ T E+ + KAP + KD + Sbjct: 2063 RRHVS--GKPDTQERWLPSSRARVKTRDRTCPVHESPSGIDTSETSPKAPRGGLAKDSGT 2120 Query: 1894 -LKATPGIKDSSAALATSTSLSAKNVIKKKGEIIILWTRNDDREILLECQKRGPSFKTFA 1952 K G + AA AT + ++K + GE ++LWTR DR IL CQ++G +TF Sbjct: 2121 QAKGPEGEQQPKAAEATVCANNSK--VSSTGEKVVLWTREADRVILTMCQEQGAQPQTFN 2178 Query: 1953 YLAAKL-DKNPNQVSERFQQLMKLF 1976 ++ +L +K P +VS RF++LM+LF Sbjct: 2179 IISQQLGNKTPAEVSHRFRELMQLF 2203 >gi|109255228 centrosomal protein 170kDa isoform alpha [Homo sapiens] Length = 1584 Score = 60.8 bits (146), Expect = 1e-08 Identities = 184/920 (20%), Positives = 349/920 (37%), Gaps = 144/920 (15%) Query: 175 SKTDHRAKSDVSKDVHHS--TSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHY 232 +K D +SD H + LE+ + H + + EKH V S +H+ Sbjct: 371 NKHDDGTQSDSENAGAHRRCSKRATLEEHLRRHHSEHKKLQKVQATEKHQDQAVTSSAHH 430 Query: 233 QVGEGSSNEDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYG 292 + G G + H + ++ ++ S + +L +S L P + Sbjct: 431 RGGHG------------VPHGKL---LKQKSEEPSVSIPFLQTALLRSSGSLGHRPSQEM 475 Query: 293 KGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQN 352 K ++ S+ + ++D D + ++ + E E P + ++ K +++ N Sbjct: 476 DKMLKNQATSATSEKDNDDD-QSDKGTYTIELENPNSE-----EVEARKMIDKVFGVDDN 529 Query: 353 INRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERR 412 QD +++K K ++KD W S A++ + +T S +H EE Sbjct: 530 --------QDYNRPVINEKHKDLIKD---WALSSAAAVMEERKPLT---TSGFHHSEEGT 575 Query: 413 GWEDCKRDKS-----VNSHSFQDGR-------CPSSLSNSRTHKNIDSKEVDAMHQWENT 460 KR S +H+ D P L N I + T Sbjct: 576 SSSGSKRWVSQWASLAANHTRHDQEERIMEFSAPLPLEN---ETEISESGMTVRSTGSAT 632 Query: 461 PLKAE---RHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEP 517 L ++ R RT + E++S E +R +R Q T + K+T T + ++++ Sbjct: 633 SLASQGERRRRTLPQLPNEEKSLESHRAKVVTQRSEIGEKQDTELQEKETPTQVYQKDKQ 692 Query: 518 KTDK------GEVLDNGVSEGADNKELAMKAESGPNETKNK-DLKLSFMKKLNLTLSPAK 570 D+ V + G DNK L S P + K++ D + S +K+ TL+ + Sbjct: 693 DADRPLSKMNRAVNGETLKTGGDNKTLLHLGSSAPGKEKSETDKETSLVKQ---TLAKLQ 749 Query: 571 KQPVSQDNQHKITDIPKSSGVCDSESSMQVKTVAYVPSISEHILGEAAVSEHTMGETKST 630 +Q ++ Q T + S V + +T E G + + +++S Sbjct: 750 QQEQREEAQWTPTKL-SSKNVSGQTDKCREETFKQESQPPEKNSGHSTSKGDRVAQSESK 808 Query: 631 LLEPKVALLAVTEPRIGISETNKEDENSLLVRSVDNTMHCEEPICGTE---------TSF 681 + + L + T P+ G +K++ + LVR T+ P E +S Sbjct: 809 RRKAEEILKSQT-PKGG----DKKESSKSLVRQGSFTIEKPSPNIPIELIPHINKQTSST 863 Query: 682 PSPMEI-------QQTESLFPSTGMKQT--INNGRAAAPVVMDVLQTDVSQNFGLELDTK 732 PS + + +++ESL P + M T + + A + L+ D + G + + Sbjct: 864 PSSLALTSASRIRERSESLDPDSSMDTTLILKDTEAVMAFLEAKLREDNKTDEGPDTPSY 923 Query: 733 RNDNSDYCGISEGMEMKVALSTTVSETTESILQPSIEEADILPIMLSEDNNPKFEPSVIV 792 DNS IS E V ++T+S T + S ++ L +D PS V Sbjct: 924 NRDNS----ISP--ESDVDTASTISLVTGETERKSTQKRKSF-TSLYKDRCSTGSPSKDV 976 Query: 793 TPLVESKSCHLEPCLPKETLDSSLQQTELMDHR---MATG-------------ETNSVYH 836 T +S S + K+T S D R ++G +T+SV H Sbjct: 977 T---KSSSSGAREKMEKKTKSRSTDVGSRADGRKFVQSSGRIRQPSVDLTDDDQTSSVPH 1033 Query: 837 DDDNSVLSIDLNHLRPIPEAISPLNSPVRPV------AKVLRNESPPQVPVYNNSHKDVF 890 + ++S D P +PL S V +KV ++++ P V ++ + Sbjct: 1034 SAISDIMSSDQETYSCKPHGRTPLTSADEHVHSKLEGSKVTKSKTSPVVSGSSSKSTTLP 1093 Query: 891 LPNSAHSTSKSQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQES 950 P ++ ++ L + + + +DK + A E+ + S TSKP Sbjct: 1094 RPRPTRTSLLRRARLGEASDSELADADKASVA-------------SEVSTTSSTSKPPTG 1140 Query: 951 FEKNSKRRVSADVRKSK--TIPRRGKS--TVCLDKDSRKTHVRIHQT------NNKWNKR 1000 S+ + A R+++ ++ R S T+ S +T I ++ ++K++ R Sbjct: 1141 RRNISRIDLLAQPRRTRLGSLSARSDSEATISRSSASSRTAEAIIRSGARLVPSDKFSPR 1200 Query: 1001 PDKSSRSSKTEKKDKVMSTS 1020 +S S ++ K K M+++ Sbjct: 1201 IRANSISRLSDSKVKSMTSA 1220 >gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo sapiens] Length = 600 Score = 60.1 bits (144), Expect = 2e-08 Identities = 54/256 (21%), Positives = 111/256 (43%), Gaps = 20/256 (7%) Query: 299 ESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEV 358 ES + + D G+ + +KE R + + ++D+K ER+ E+ ++ RK Sbjct: 35 ESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRH--RKRD 92 Query: 359 KSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCK 418 + ++++ + ++ + +++D R ER + E ER G + Sbjct: 93 RHRERQRDREKERERQTDRERDRQREKERNRQKERERET------------EREG--ERG 138 Query: 419 RDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQE 478 RD+ + ++ + + R ++ + Q E K + R E +R+RE+E Sbjct: 139 RDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKE 198 Query: 479 SKEENRHIRNEKRVPTEHLQKTNKET-KKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKE 537 +K E+RH +E+ E ++T ET +K TD ++ + KT++ E E A +E Sbjct: 199 NKTEDRH--SERGRERERERETETETERKRQTDRERDRQRKTER-EREKQAERERASERE 255 Query: 538 LAMKAESGPNETKNKD 553 E +++D Sbjct: 256 TERDKERERERDRDRD 271 Score = 51.6 bits (122), Expect = 8e-06 Identities = 69/365 (18%), Positives = 126/365 (34%), Gaps = 38/365 (10%) Query: 163 DLKSRSPHLDDCSKTDHRAKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHC 222 D R P + + R KD N +KE + +KR T + Sbjct: 25 DFSRRRPGSQESPR--RRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERR 82 Query: 223 TNGVWSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQ 282 R + E + + R R+ R R ER R+ + E + Sbjct: 83 REKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGE-RGRDR 141 Query: 283 RLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKK 342 + G E+ + + + E + + + + EK R R + +K Sbjct: 142 QTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKT 201 Query: 343 LERQSERSQNINR-KEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSH 401 +R SER + R +E +++ + +R+ D +++D R++ER ++ E Sbjct: 202 EDRHSERGRERERERETETETERKRQTD-------RERDRQRKTEREREKQAERERASER 254 Query: 402 NSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTP 461 + + ER D RD+ Q R Sbjct: 255 ETERDKERERERDRDRDRDRRQKERERQTDR--------------------------KRQ 288 Query: 462 LKAERHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDK 521 + ER R E +RKRE++ + E RN KR ++ + ++T D +K+ E K + Sbjct: 289 RRTERDR-ETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKR 347 Query: 522 GEVLD 526 +D Sbjct: 348 QTEMD 352 Score = 48.1 bits (113), Expect = 8e-05 Identities = 56/292 (19%), Positives = 113/292 (38%), Gaps = 25/292 (8%) Query: 243 SRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTES-- 300 + R R+ R + NR R R+ E R E + + E + E K ++ Sbjct: 171 TERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDR 230 Query: 301 -KSSKFKSNSDSDYKGERINSSW-----EKETPGERSHSRVDSQSDKKLERQSERSQNIN 354 + + K+ + + + ER +S +KE ER R + K+ ERQ++R Sbjct: 231 ERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDR----K 286 Query: 355 RKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGW 414 R+ +D+E + ++ + ++++ R+ ER + E + ER+ Sbjct: 287 RQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRK 346 Query: 415 EDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRK 474 + D+ N + ++GR + R +E D E + +R R K + Sbjct: 347 RQTEMDRERNRQTGREGRRQAERERER------ERERDRQSAREREERERDRDRDRQKER 400 Query: 475 REQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLD 526 Q K+ + EK Q+ ++ +++ ++ E + KG D Sbjct: 401 ERQTEKDRDGQRETEK-------QREREKDRESERGRERGREREKQKGRERD 445 >gi|109255230 centrosomal protein 170kDa isoform beta [Homo sapiens] Length = 1486 Score = 60.1 bits (144), Expect = 2e-08 Identities = 165/796 (20%), Positives = 305/796 (38%), Gaps = 118/796 (14%) Query: 301 KSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEV-- 358 K +K + SD + + K E H R KKL++ ++ ++ V Sbjct: 369 KGNKHDDGTQSDSENAGAHRRCSKRATLEE-HLRRHHSEHKKLQKVQATEKHQDQAVVFG 427 Query: 359 --KSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWED 416 +QD +++K K ++KD W S A++ + +T S +H EE Sbjct: 428 VDDNQDYNRPVINEKHKDLIKD---WALSSAAAVMEERKPLT---TSGFHHSEEGTSSSG 481 Query: 417 CKRDKS-----VNSHSFQDGR-------CPSSLSNSRTHKNIDSKEVDAMHQWENTPLKA 464 KR S +H+ D P L N I + T L + Sbjct: 482 SKRWVSQWASLAANHTRHDQEERIMEFSAPLPLENET---EISESGMTVRSTGSATSLAS 538 Query: 465 E---RHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDK 521 + R RT + E++S E +R +R Q T + K+T T + ++++ D+ Sbjct: 539 QGERRRRTLPQLPNEEKSLESHRAKVVTQRSEIGEKQDTELQEKETPTQVYQKDKQDADR 598 Query: 522 G------EVLDNGVSEGADNKELAMKAESGPNETKNK-DLKLSFMKKLNLTLSPAKKQPV 574 V + G DNK L S P + K++ D + S +K+ TL+ ++Q Sbjct: 599 PLSKMNRAVNGETLKTGGDNKTLLHLGSSAPGKEKSETDKETSLVKQ---TLAKLQQQEQ 655 Query: 575 SQDNQHKITDIPKSSGVCDSESSMQVKTVAYVPSISEHILGEAAVSEHTMGETKSTLLEP 634 ++ Q T + S V + +T E G + + +++S + Sbjct: 656 REEAQWTPTKL-SSKNVSGQTDKCREETFKQESQPPEKNSGHSTSKGDRVAQSESKRRKA 714 Query: 635 KVALLAVTEPRIGISETNKEDENSLLVRSVDNTMHCEEPICGTE---------TSFPSPM 685 + L + T P+ G +K++ + LVR T+ P E +S PS + Sbjct: 715 EEILKSQT-PKGG----DKKESSKSLVRQGSFTIEKPSPNIPIELIPHINKQTSSTPSSL 769 Query: 686 EI-------QQTESLFPSTGMKQT--INNGRAAAPVVMDVLQTDVSQNFGLELDTKRNDN 736 + +++ESL P + M T + + A + L+ D + G + + DN Sbjct: 770 ALTSASRIRERSESLDPDSSMDTTLILKDTEAVMAFLEAKLREDNKTDEGPDTPSYNRDN 829 Query: 737 SDYCGISEGMEMKVALSTTVSETTESILQPSIEEADILPIMLSEDNNPKFEPSVIVTPLV 796 S IS E V ++T+S T + S ++ L +D PS VT Sbjct: 830 S----ISP--ESDVDTASTISLVTGETERKSTQKRKSF-TSLYKDRCSTGSPSKDVT--- 879 Query: 797 ESKSCHLEPCLPKETLDSSLQQTELMDHR---MATG-------------ETNSVYHDDDN 840 +S S + K+T S D R ++G +T+SV H + Sbjct: 880 KSSSSGAREKMEKKTKSRSTDVGSRADGRKFVQSSGRIRQPSVDLTDDDQTSSVPHSAIS 939 Query: 841 SVLSIDLNHLRPIPEAISPLNSPVRPV------AKVLRNESPPQVPVYNNSHKDVFLPNS 894 ++S D P +PL S V +KV ++++ P V ++ + P Sbjct: 940 DIMSSDQETYSCKPHGRTPLTSADEHVHSKLEGSKVTKSKTSPVVSGSSSKSTTLPRPRP 999 Query: 895 AHSTSKSQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKN 954 ++ ++ L + + + +DK + A E+ + S TSKP Sbjct: 1000 TRTSLLRRARLGEASDSELADADKASVA-------------SEVSTTSSTSKPPTGRRNI 1046 Query: 955 SKRRVSADVRKSK--TIPRRGKS--TVCLDKDSRKTHVRIHQT------NNKWNKRPDKS 1004 S+ + A R+++ ++ R S T+ S +T I ++ ++K++ R + Sbjct: 1047 SRIDLLAQPRRTRLGSLSARSDSEATISRSSASSRTAEAIIRSGARLVPSDKFSPRIRAN 1106 Query: 1005 SRSSKTEKKDKVMSTS 1020 S S ++ K K M+++ Sbjct: 1107 SISRLSDSKVKSMTSA 1122 >gi|109255232 centrosomal protein 170kDa isoform gamma [Homo sapiens] Length = 1460 Score = 60.1 bits (144), Expect = 2e-08 Identities = 165/796 (20%), Positives = 305/796 (38%), Gaps = 118/796 (14%) Query: 301 KSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEV-- 358 K +K + SD + + K E H R KKL++ ++ ++ V Sbjct: 369 KGNKHDDGTQSDSENAGAHRRCSKRATLEE-HLRRHHSEHKKLQKVQATEKHQDQAVVFG 427 Query: 359 --KSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWED 416 +QD +++K K ++KD W S A++ + +T S +H EE Sbjct: 428 VDDNQDYNRPVINEKHKDLIKD---WALSSAAAVMEERKPLT---TSGFHHSEEGTSSSG 481 Query: 417 CKRDKS-----VNSHSFQDGR-------CPSSLSNSRTHKNIDSKEVDAMHQWENTPLKA 464 KR S +H+ D P L N I + T L + Sbjct: 482 SKRWVSQWASLAANHTRHDQEERIMEFSAPLPLENET---EISESGMTVRSTGSATSLAS 538 Query: 465 E---RHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDK 521 + R RT + E++S E +R +R Q T + K+T T + ++++ D+ Sbjct: 539 QGERRRRTLPQLPNEEKSLESHRAKVVTQRSEIGEKQDTELQEKETPTQVYQKDKQDADR 598 Query: 522 G------EVLDNGVSEGADNKELAMKAESGPNETKNK-DLKLSFMKKLNLTLSPAKKQPV 574 V + G DNK L S P + K++ D + S +K+ TL+ ++Q Sbjct: 599 PLSKMNRAVNGETLKTGGDNKTLLHLGSSAPGKEKSETDKETSLVKQ---TLAKLQQQEQ 655 Query: 575 SQDNQHKITDIPKSSGVCDSESSMQVKTVAYVPSISEHILGEAAVSEHTMGETKSTLLEP 634 ++ Q T + S V + +T E G + + +++S + Sbjct: 656 REEAQWTPTKL-SSKNVSGQTDKCREETFKQESQPPEKNSGHSTSKGDRVAQSESKRRKA 714 Query: 635 KVALLAVTEPRIGISETNKEDENSLLVRSVDNTMHCEEPICGTE---------TSFPSPM 685 + L + T P+ G +K++ + LVR T+ P E +S PS + Sbjct: 715 EEILKSQT-PKGG----DKKESSKSLVRQGSFTIEKPSPNIPIELIPHINKQTSSTPSSL 769 Query: 686 EI-------QQTESLFPSTGMKQT--INNGRAAAPVVMDVLQTDVSQNFGLELDTKRNDN 736 + +++ESL P + M T + + A + L+ D + G + + DN Sbjct: 770 ALTSASRIRERSESLDPDSSMDTTLILKDTEAVMAFLEAKLREDNKTDEGPDTPSYNRDN 829 Query: 737 SDYCGISEGMEMKVALSTTVSETTESILQPSIEEADILPIMLSEDNNPKFEPSVIVTPLV 796 S IS E V ++T+S T + S ++ L +D PS VT Sbjct: 830 S----ISP--ESDVDTASTISLVTGETERKSTQKRKSF-TSLYKDRCSTGSPSKDVT--- 879 Query: 797 ESKSCHLEPCLPKETLDSSLQQTELMDHR---MATG-------------ETNSVYHDDDN 840 +S S + K+T S D R ++G +T+SV H + Sbjct: 880 KSSSSGAREKMEKKTKSRSTDVGSRADGRKFVQSSGRIRQPSVDLTDDDQTSSVPHSAIS 939 Query: 841 SVLSIDLNHLRPIPEAISPLNSPVRPV------AKVLRNESPPQVPVYNNSHKDVFLPNS 894 ++S D P +PL S V +KV ++++ P V ++ + P Sbjct: 940 DIMSSDQETYSCKPHGRTPLTSADEHVHSKLEGSKVTKSKTSPVVSGSSSKSTTLPRPRP 999 Query: 895 AHSTSKSQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKN 954 ++ ++ L + + + +DK + A E+ + S TSKP Sbjct: 1000 TRTSLLRRARLGEASDSELADADKASVA-------------SEVSTTSSTSKPPTGRRNI 1046 Query: 955 SKRRVSADVRKSK--TIPRRGKS--TVCLDKDSRKTHVRIHQT------NNKWNKRPDKS 1004 S+ + A R+++ ++ R S T+ S +T I ++ ++K++ R + Sbjct: 1047 SRIDLLAQPRRTRLGSLSARSDSEATISRSSASSRTAEAIIRSGARLVPSDKFSPRIRAN 1106 Query: 1005 SRSSKTEKKDKVMSTS 1020 S S ++ K K M+++ Sbjct: 1107 SISRLSDSKVKSMTSA 1122 >gi|148746195 trichohyalin [Homo sapiens] Length = 1943 Score = 59.7 bits (143), Expect = 3e-08 Identities = 60/304 (19%), Positives = 128/304 (42%), Gaps = 22/304 (7%) Query: 261 RVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINS 320 R R++L E E Q L+ PEK + E + + + + + E Sbjct: 1071 RRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREK 1130 Query: 321 SWEKETPGE-RSHSRVDSQSDKKLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQ 379 +E + R V + ++ L + E+ + R+E++ Q +EE ++ Q+ + +++++ Sbjct: 1131 RRRQELERQYREEEEVQQEEEQLLREEPEKRR---RQELERQYREEEELQQEEEQLLREE 1187 Query: 380 DHWRRSERASLPHSKNEITFSHNSSKYHLEERRG-----WEDCKRDKSVNSHSFQDGRCP 434 RR ER + E+ +Y E++R WE K + ++ + GR Sbjct: 1188 QEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGR-- 1245 Query: 435 SSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESK---EENRHIRNEKR 491 N + + DS+ D Q + L E + +R REQE + + +RH E++ Sbjct: 1246 ---ENEQFRQLEDSQLRDRQSQQDLQHLLGE----QQERDREQERRRWQQRDRHFPEEEQ 1298 Query: 492 VPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAMKAESGPNETKN 551 + E ++ + +K+ + + E + +K + + + ++L + E P + Sbjct: 1299 LEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETD-RKFREEEQLLQEREEQPLRRQE 1357 Query: 552 KDLK 555 +D K Sbjct: 1358 RDRK 1361 Score = 50.1 bits (118), Expect = 2e-05 Identities = 82/433 (18%), Positives = 162/433 (37%), Gaps = 41/433 (9%) Query: 95 KEIQTQNFSLINENQSLKKNISALIKTARVEINRKDEEISNLHQRLSEFPHFRNNHKTAR 154 +E+Q + L+ E + K+ L + R E + EE Q L E P R + R Sbjct: 1114 EELQQEEEQLLREERE-KRRRQELERQYREEEEVQQEE----EQLLREEPEKRRRQELER 1168 Query: 155 TFDTVKTKDLKSRSPHLDDCSKTDHRAKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHL 214 + + ++L+ L + + + + + L +K + + D+ S L Sbjct: 1169 QYR--EEEELQQEEEQL--LREEQEKRRQERERQYREEEELQR-QKRKQRYRDEDQRSDL 1223 Query: 215 PTSVEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGE 274 E N V Y +G NE R+ + SQ + ++DL G+ + Sbjct: 1224 KWQWEPEKENAVRDNKVYC--KGRENEQFRQ----LEDSQLR--DRQSQQDLQHLLGEQQ 1275 Query: 275 PRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSR 334 R E +R +++ E + E + K D + E+ + ER R Sbjct: 1276 ERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEK------QLLREEREEKR 1329 Query: 335 VDSQSDKKLERQSERSQNINRKEVKSQDK------EERKVDQKPKSVVKDQDHWRRSERA 388 ++D+K + + Q + ++ Q++ EE + ++ + ++++ RR ER Sbjct: 1330 RRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQER- 1388 Query: 389 SLPHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDS 448 E F + +ER RD+ Q R + + Sbjct: 1389 -------ERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRR 1441 Query: 449 KEVDAMHQWENTPLKAERH---RTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNKETK 505 +E + E L+ ERH R E++ +E+E ++ +R R+ K + E + + + Sbjct: 1442 QERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDR 1501 Query: 506 KTTTDLKKQNEPK 518 K + EP+ Sbjct: 1502 KFREQELRSQEPE 1514 Score = 49.3 bits (116), Expect = 4e-05 Identities = 59/334 (17%), Positives = 137/334 (41%), Gaps = 28/334 (8%) Query: 244 RRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTESKSS 303 R+ ++ R Q R ++ R++ E R + + + E+ + E + E + Sbjct: 308 RKQEEERREQQEERREQQERREQQE-----ERREQQLRREQEERREQQLRREQEEERREQ 362 Query: 304 KFKSNSDSDYKGERINSSWEKETPGE-------RSHSRVDSQSDKKLERQSERSQNINRK 356 + + + + + +++ + + R ++ + + E+Q R Q + R+ Sbjct: 363 QLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 422 Query: 357 EVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWED 416 + +++EE + +QK + ++Q R E + E T H + + +R E+ Sbjct: 423 QQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEE 482 Query: 417 CKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKRE 476 +R++ + ++ R + + + + + + E +R R+E + +RE Sbjct: 483 ERRERWLKLEE-EERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRRE 541 Query: 477 QESKEENRHIR-NEKRVPTEHLQKTNKETKKTTTD--LKKQNEP-----KTDKGEVLDNG 528 QE + E R EKR+ E ++ K ++ D LK++ E K ++ E L+ Sbjct: 542 QEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQR 601 Query: 529 VS-------EGADNKELAMKAESGPNETKNKDLK 555 + E + +E +K E E + + LK Sbjct: 602 LKREEVERLEQEERREQRLKREEPEEERRQQLLK 635 Score = 49.3 bits (116), Expect = 4e-05 Identities = 83/501 (16%), Positives = 184/501 (36%), Gaps = 58/501 (11%) Query: 55 LDLYEEILTEEGTAKEATYNDLQVEYGKCQLQMKELMKKFKEIQTQNFSLINENQSLKKN 114 L L EE E+ +E Q E + +L+ +E ++ ++ L E + ++ Sbjct: 489 LKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQ 548 Query: 115 ISALIKTARVEINRKDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPH---- 170 + + R+E R+++ + + + R + + + + L+ R Sbjct: 549 LLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVE 608 Query: 171 -LDDCSKTDHRAKSDVSKDVHHSTSLPNLEKEGKPHSD------KRSTSHLPTSVEKHCT 223 L+ + + R K + ++ L + E+E + +R L E+ Sbjct: 609 RLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERL 668 Query: 224 NGVWSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRGTERVRK-------------DLSTGC 270 R H E+ RR +++ + + ER++ D Sbjct: 669 EQRLKREH---------EEERR-EQELAEEEQEQARERIKSRIPKWQWQLESEADARQSK 718 Query: 271 GDGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGER-INSSWEKETPGE 329 PR E +R Q EK + E + + + + + + R W+ E E Sbjct: 719 VYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSE 778 Query: 330 RSHSRVDS------QSDKKL---ERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQD 380 R R+ + Q +++L ERQ + + +E K Q + +R+ +K +++++ Sbjct: 779 RGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEE 838 Query: 381 HWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNS 440 +R ERA + + +ERR ++ +RD+ ++ + Sbjct: 839 QLQRRERAQQLQEEED-------GLQEDQERRRSQEQRRDQKWRWQLEEERK-------R 884 Query: 441 RTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKT 500 R H + + E L+ E + + + ++ +E+ R R E+++ E Q Sbjct: 885 RRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLL 944 Query: 501 NKETKKTTTDLKKQNEPKTDK 521 +E +K +++ K K Sbjct: 945 REEREKRRRQERERQYRKDKK 965 Score = 46.2 bits (108), Expect = 3e-04 Identities = 81/482 (16%), Positives = 176/482 (36%), Gaps = 73/482 (15%) Query: 84 QLQMKELMKKFKEIQTQ------NFSLINENQSLKKNISALIKTARVEINRKDEEISNLH 137 QL +E +KF+E + Q + E Q L++ + + ++E+ + Sbjct: 1422 QLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQ 1481 Query: 138 QRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTD--HRAKSDVSKDVHHSTSL 195 +R +F + + ++L+S+ P + HR + K + L Sbjct: 1482 ERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQ-RKFLQEEQQL 1540 Query: 196 PNLEKEGKPHSDK----RSTSHLPTSVEKHCTNGVWSRSHYQVGEGS--SNEDSRRGRKD 249 E+ + D+ R L E+ + +++ E E R+ +D Sbjct: 1541 RRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMED 1600 Query: 250 IRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRL---QGHPEKYGKGEPKTESKSSKFK 306 + + G +++R++ + E + E ++ Q K+ + EP+ + + + Sbjct: 1601 EQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQ 1660 Query: 307 SNSDSDYK---GERINSSWEKETPGERSHSRVDSQSDKKLERQS------ERSQNINRKE 357 D D K E++ E++ + R + +++L RQ + Q + R+E Sbjct: 1661 LRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQE 1720 Query: 358 VKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEER----RG 413 ++ + +EE ++ Q+ +Q+ RR ER + ++ + +ER R Sbjct: 1721 LERKFREEEQLRQET-----EQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFRE 1775 Query: 414 WEDCKRDKSVNSHSFQDG----RCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRT 469 E ++++ Q+ R L R + + ++ D ++WE L+ E Sbjct: 1776 EEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQ 1835 Query: 470 ---------------------------------EDKRKREQESKEENRHIRNEKRVPTEH 496 E KR++E+E K HIR +++ H Sbjct: 1836 RLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRH 1895 Query: 497 LQ 498 Q Sbjct: 1896 RQ 1897 Score = 42.7 bits (99), Expect = 0.004 Identities = 54/268 (20%), Positives = 111/268 (41%), Gaps = 15/268 (5%) Query: 245 RGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRL-QGHPEKYGKGEPKT--ESK 301 +GRK + Q R ER RK L + + R E Q+L Q K+ + E + + + Sbjct: 1372 QGRKFLEEEQRLRRQERERKFLKE---EQQLRCQEREQQLRQDRDRKFREEEQQLSRQER 1428 Query: 302 SSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKSQ 361 KF+ + ER E+E + R + ++ L+ + E+ + ++ K Sbjct: 1429 DRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFL 1488 Query: 362 DKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEER--RGWEDCKR 419 ++E++ Q+ ++Q+ + + ++ K+ EE+ R E ++ Sbjct: 1489 EEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQ 1548 Query: 420 DKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLK---AERHRTEDKRK-R 475 + F++ L R + + +E D + E ++ ER ED+++ R Sbjct: 1549 RRQDRDRKFRE---EEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLR 1605 Query: 476 EQESKEENRHIRNEKRVPTEHLQKTNKE 503 QE +++ R R+ K E L + +E Sbjct: 1606 RQEGQQQLRQERDRKFREDEQLLQEREE 1633 Score = 41.6 bits (96), Expect = 0.008 Identities = 65/357 (18%), Positives = 135/357 (37%), Gaps = 37/357 (10%) Query: 245 RGRKDIRHSQFNRGTERVRKDLSTGCGDGEP--RILEASQRL--QGHPEKYGKGEPKTES 300 R RK + Q R ER RK EP + LE Q+L Q K+ + E + Sbjct: 1483 RDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRR 1542 Query: 301 KSSKFKSNSDSDYK---GERINSSWEKETPGERSHSRVDSQSDKKLERQS-ERSQNINRK 356 + + D D K E++ E++ + R ++K+ RQ ER + + Sbjct: 1543 QERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQ 1602 Query: 357 EVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWED 416 +++ Q+ +++ ++ + +D+ + E L + + F + +ER Sbjct: 1603 QLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLR 1662 Query: 417 CKRDKSVNSHS--FQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAE--------- 465 RD+ Q+G R K + ++ + E L+ E Sbjct: 1663 HDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELE 1722 Query: 466 -RHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEV 524 + R E++ ++E E ++ R R K + E L+ +E + L++Q + + E Sbjct: 1723 RKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQ-----LRRQERDRKFREE- 1776 Query: 525 LDNGVSEGADNKELAMKAESGPNETKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHK 581 ++L + E ++ D K ++L + +P +D +++ Sbjct: 1777 -----------EQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYR 1822 Score = 41.2 bits (95), Expect = 0.010 Identities = 44/246 (17%), Positives = 104/246 (42%), Gaps = 16/246 (6%) Query: 283 RLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERI-----NSSWEKETPGERSHSRVDS 337 R +G EK + + E + F+ + +++ ++E P + + + Sbjct: 219 RRKGREEKQ---QQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEE 275 Query: 338 QSDKKLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRR--SERASLPHSKN 395 + +KLERQ R + ++ + + + E+++ +K + ++Q RR ER + Sbjct: 276 EQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERR 335 Query: 396 EITFSHNSSKYHLEE-RRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAM 454 E + ++ RR E+ +R++ + ++ R L + + + Sbjct: 336 EQQLRREQEERREQQLRREQEEERREQQLRREQ-EEERREQQLRREQQLRREQQLRREQQ 394 Query: 455 HQWENTPLKAERHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQ 514 + E + ++ R E + +REQ+ + E + R ++ H QK +E ++ LK++ Sbjct: 395 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQEE--ERHEQKHEQERREQR--LKRE 450 Query: 515 NEPKTD 520 E + D Sbjct: 451 QEERRD 456 Score = 39.3 bits (90), Expect = 0.039 Identities = 50/317 (15%), Positives = 122/317 (38%), Gaps = 46/317 (14%) Query: 231 HYQVGEGSSNEDSRRGR--------KDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQ 282 +Y +G+ + ++ +R R +D R + R E + L G + + + Sbjct: 86 YYALGQATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQE 145 Query: 283 RLQGHPEKYGKGEPKTESKS------------SKFKSNSDSDYKGERINSSWEKET---P 327 R E+ + + + E + +++ + + E++ S ET P Sbjct: 146 RELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFP 205 Query: 328 GERSHSRVDSQSDKKLERQSERSQNINRKEVKSQDKEER------------------KVD 369 E R + ++ R+ ++ Q R++ Q++EE+ + Sbjct: 206 DEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEP 265 Query: 370 QKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQ 429 Q+ + + ++++ R+ ER L + E + + RR E+ +R++ Q Sbjct: 266 QRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQ 325 Query: 430 DGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESKEENRHIRNE 489 + R R + + ++ + Q + E R E + +REQE + + +R E Sbjct: 326 ERR---EQQEERREQQLRREQEERREQ--QLRREQEEERREQQLRREQEEERREQQLRRE 380 Query: 490 KRVPTEHLQKTNKETKK 506 +++ E + ++ ++ Sbjct: 381 QQLRREQQLRREQQLRR 397 Score = 38.1 bits (87), Expect = 0.086 Identities = 57/340 (16%), Positives = 127/340 (37%), Gaps = 28/340 (8%) Query: 236 EGSSNEDSRRGRKDIRHSQ---FNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYG 292 +G + RR ++ R Q + ER R+ + L Q+L E+ Sbjct: 854 DGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEE-- 911 Query: 293 KGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQN 352 E + E + + + + Y+ E+E + + + +K+ ++ ER Sbjct: 912 --ELQREEREKRRRQEQERQYR--------EEEQLQQEEEQLLREEREKRRRQERERQY- 960 Query: 353 INRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERR 412 RK+ K Q KEE+ + ++P+ + + + E L + ++ + E R Sbjct: 961 --RKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWER 1018 Query: 413 GW----EDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHR 468 + E + ++ + + R R + + +E + + T + E R Sbjct: 1019 QYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELER 1078 Query: 469 TEDKRKREQESKEENRHIRNE----KRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEV 524 RK E+ +EE + +R E +R E + +E ++ L ++ K + E+ Sbjct: 1079 --QYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQEL 1136 Query: 525 LDNGVSEGADNKELAMKAESGPNETKNKDLKLSFMKKLNL 564 E +E P + + ++L+ + ++ L Sbjct: 1137 ERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEEL 1176 >gi|6631100 natural killer-tumor recognition sequence [Homo sapiens] Length = 1462 Score = 59.3 bits (142), Expect = 4e-08 Identities = 188/1001 (18%), Positives = 333/1001 (33%), Gaps = 179/1001 (17%) Query: 149 NHKTARTFDTVKTKDLKSRSPHLDDCSKTDHRAKSDVSKDVHHSTSLPNLEKEGKPHSDK 208 +HK R VK K + H +T R + + D+ S S + K D+ Sbjct: 426 HHKKRRKEKKVKHKKKGKKQKHCRRHKQTKKR-RILIPSDIESSKSST---RRMKSSCDR 481 Query: 209 RSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDIRHSQ-FNRGTERVRKDLS 267 +S + H + WS+S V + S SR + HSQ ++RG+ R R S Sbjct: 482 ERSSRSSSLSSHHSSKRDWSKSDKDV-QSSLTHSSRDSYRSKSHSQSYSRGSSRSRT-AS 539 Query: 268 TGCGDGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERIN-------- 319 R S GH ++ K KT S+ S+ K + Sbjct: 540 KSSSHSRSRSKSRSSSKSGHRKRASKSPRKTASQLSENKPVKTEPLRATMAQNENVVVQP 599 Query: 320 -----------------SSWEK-ETPGERSHSRVD------------------------- 336 S W+ + P + S+ R+ Sbjct: 600 VVAENIPVIPLSDSPPPSRWKPGQKPWKPSYERIQEMKAKTTHLLPIQSTYSLANIKETG 659 Query: 337 -SQSDKKLERQSERSQNINRK-EVKSQDKEERKVDQKPKSVVKDQDHWR-RSERASLPHS 393 S S K E+ SE Q+ K +S + R + +S + + R RS +S S Sbjct: 660 SSSSYHKREKNSESDQSTYSKYSDRSSESSPRSRSRSSRSRSYSRSYTRSRSLASSHSRS 719 Query: 394 KNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGR------CPSSLSNSRTHKNID 447 ++ + SH+ +KY + C R S S S DGR S NS +HK Sbjct: 720 RSPSSRSHSRNKYSDHSQ-----CSRSSSYTSISSDDGRRAKRRLRSSGKKNSVSHKKHS 774 Query: 448 SKEVDAMH-----------------------------------------------QWENT 460 S +H Q E T Sbjct: 775 SSSEKTLHSKYVKGRDRSSCVRKYSESRSSLDYSSDSEQSSVQATQSAQEKEKQGQMERT 834 Query: 461 PLKAERHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTD 520 K E++R E+K K E+E + R K ++HL+ +K +K K +E ++ Sbjct: 835 HNKQEKNRGEEKSKSERECPHSKK--RTLKENLSDHLRNGSKPKRKNYAGSKWDSESNSE 892 Query: 521 KGEVLDNGVSEG--ADNKELAMKAESGPNETKNKDLKLSFMKKLNLTLSPAKKQPVSQDN 578 + +V N ++ + +KE +E +K+ K + S + + Sbjct: 893 R-DVTKNSKNDSHPSSDKEEGEATSDSESEVSEIHIKVKPTTKSSTNTSLPDDNGAWKSS 951 Query: 579 QHKITDIPKSSGVCDSESSMQVKTVAYVPSISEHILGE--AAVSEHTMGETKSTLLEPKV 636 + + T S G C + + + K + E++ E V E G+ PK Sbjct: 952 KQR-TSTSDSEGSCSNSENNRGKPQKHKHGSKENLKREHTKKVKEKLKGKKDKKHKAPKR 1010 Query: 637 ALLAVTEPRIGISETNKED----------------ENSLLVRS--VDNTMHCEEPICGTE 678 +P + E +E+ EN+ ++ + EE + G Sbjct: 1011 KQAFHWQPPLEFGEEEEEEIDDKQVTQESKEKKVSENNETIKDNILKTEKSSEEDLSGKH 1070 Query: 679 TSFPSPMEIQQTESLFPSTGMKQTINNGRAAAPVVMDVLQTDVSQNFGLELDTKRNDNSD 738 + ++ Q + T N + ++ + S G+E + +DN + Sbjct: 1071 DTVTVSSDLDQFTKDDSKLSISPTALNTEENVACLQNIQHVEESVPNGVEDVLQTDDNME 1130 Query: 739 YCGISEGMEMKVALSTTVSETTESILQPSIEEADILPIMLSED---NNPKFEPSVIVTPL 795 C KV E T + ++ DI I+L +D +P+ E + + Sbjct: 1131 ICTPDRSSPAKV-------EETSPLGNARLDTPDI-NIVLKQDMATEHPQAEVVKQESSM 1182 Query: 796 VESKSCHLEPCLPKETLDSSLQQTELMDHRMATGETNSVYHDDDNSVLSIDLNHLRPIPE 855 ESK L +Q + GE+ + S +++ +P+ + Sbjct: 1183 SESK-----------VLGEVGKQDSSSASLASAGESTGKKEVAEKSQINLIDKKWKPL-Q 1230 Query: 856 AISPLNSPVRPVA-----KVLRN--ESPPQVPVYNNSHKDVFLPNSAHSTSKSQSDLNKE 908 + L +P + KVL E PQ K+ P S + + LN+ Sbjct: 1231 GVGNLAAPNAATSSAVEVKVLTTVPEMKPQGLRIEIKSKNKVRPGSLFDEVRKTARLNRR 1290 Query: 909 NQKPIYKSDKCT---EADTCKNSPLDELEEGEIRSDSETSKPQESFEKNSKRRVSADVRK 965 + SD+ T + D+ SP + E +S T S ++ R ++ R Sbjct: 1291 PRNQESSSDEQTPSRDDDSQSRSPSRSRSKSETKSRHRTRSVSYSHSRSRSRSSTSSYRS 1350 Query: 966 SKTIPRRGKSTVCLDKD-SRKTHVRIHQTNNKWNKRPDKSS 1005 R + + SR + R ++++ ++ +SS Sbjct: 1351 RSYSRSRSRGWYSRGRTRSRSSSYRSYKSHRTSSRSRSRSS 1391 Score = 47.4 bits (111), Expect = 1e-04 Identities = 79/406 (19%), Positives = 143/406 (35%), Gaps = 54/406 (13%) Query: 160 KTKDLKSRSPHLDDCSKTDHRAKSDVSKDVHHSTSLPNLEKE------GKPHSDKRSTSH 213 K + + S D S + ++S ++ H S K K + S+S Sbjct: 187 KKRKKPTHSEGSDSSSNSSSSSESSSESELEHERSRRRKHKRRPKVKRSKKRRKEASSSE 246 Query: 214 LPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDI-RHSQFNRGTER---VRKDLSTG 269 P + KH N E S + S + K + R + E +R+D+ Sbjct: 247 EPRN--KHAMNPKGHSERSDTNEKRSVDSSAKREKPVVRPEEIPPVPENRFLLRRDMPVV 304 Query: 270 CGDGEPRILEASQRLQGHPEKYGKGEPKTESKS---------SKFKSNSDSDYKGE---- 316 + EP+I + + + K K + + S+ S SD D E Sbjct: 305 TAEPEPKIPDVAPIVSDQKPSVSKSGRKIKGRGTIRYHTPPRSRSCSESDDDDSSETPPH 364 Query: 317 ------RINS----SWEKETPGERSHSRVDSQSDKKLERQSERSQNIN----------RK 356 R+ + S EK + G++ S+ D++ Q RS + N Sbjct: 365 WKEEMQRLRAYRPPSGEKWSKGDKLSDPCSSRWDERSLSQRSRSWSYNGYYSDLSTARHS 424 Query: 357 EVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWED 416 + ++E+KV K K K Q H RR ++ K I + RR Sbjct: 425 GHHKKRRKEKKVKHKKKG--KKQKHCRRHKQTK----KRRILIPSDIESSKSSTRRMKSS 478 Query: 417 CKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKRE 476 C R++S S S S S++ K++ S + + ++ + R R Sbjct: 479 CDRERSSRSSSLSSHHS-SKRDWSKSDKDVQSSLTHSSRDSYRSKSHSQSYSRGSSRSRT 537 Query: 477 QESKEENRHIRNEKRVPTE--HLQKTNKETKKTTTDLKKQNEPKTD 520 + R++ R ++ H ++ +K +KT + L + KT+ Sbjct: 538 ASKSSSHSRSRSKSRSSSKSGHRKRASKSPRKTASQLSENKPVKTE 583 Score = 40.8 bits (94), Expect = 0.013 Identities = 88/362 (24%), Positives = 132/362 (36%), Gaps = 71/362 (19%) Query: 1163 EGKLEKT----SKQNAQYSNSQKRSVDNSNRELLKEKLSKSEDPVHYKSLVGCKKSEENY 1218 +G++E+T K + + +R +S + LKE LS H ++ G K +NY Sbjct: 828 QGQMERTHNKQEKNRGEEKSKSERECPHSKKRTLKENLSD-----HLRN--GSKPKRKNY 880 Query: 1219 QDQNNSSINTVKHDIKKNFNICFDNIKNSQSEERSLEVHCPSTPKSEKNEGSSIEDAQTS 1278 S + + D+ KN KN S P S+K EG + D+++ Sbjct: 881 AGSKWDSESNSERDVTKNS-------KND------------SHPSSDKEEGEATSDSESE 921 Query: 1279 Q---HATLKPERSFEILTEQQASSLTFNLVSDAQMGEIFKSLLQGSDLLDSSVNCTEKSE 1335 H +KP SS +L D +KS Q + DS +C+ SE Sbjct: 922 VSEIHIKVKPTTK---------SSTNTSLPDD---NGAWKSSKQRTSTSDSEGSCSN-SE 968 Query: 1336 WELKTPEKQL---LETLKCESIPACTTEELVSGVASP---CPKMISDDNWSLLSSEKGPS 1389 P+K E LK E +E + G PK +W P Sbjct: 969 NNRGKPQKHKHGSKENLKREHTKK--VKEKLKGKKDKKHKAPKRKQAFHWQ-------PP 1019 Query: 1390 LSSGLSLPVHPD---VLDESCMFEVSTNLPLSKDNVCSVEKSKPCVSSILLEDLAVSLTV 1446 L G D V ES +VS N KDN+ EKS S + + VS + Sbjct: 1020 LEFGEEEEEEIDDKQVTQESKEKKVSENNETIKDNILKTEKSSEEDLSGKHDTVTVSSDL 1079 Query: 1447 PSPLKSDGHLSFLKPDMSSSSTPEEVIS----AHFSEDALLEEEDASEQDIHLALESDNS 1502 K D LS ++ +T E V H E ED + D ++ + + + Sbjct: 1080 DQFTKDDSKLSI---SPTALNTEENVACLQNIQHVEESVPNGVEDVLQTDDNMEICTPDR 1136 Query: 1503 SS 1504 SS Sbjct: 1137 SS 1138 Score = 38.9 bits (89), Expect = 0.051 Identities = 58/313 (18%), Positives = 116/313 (37%), Gaps = 52/313 (16%) Query: 91 MKKFKEIQTQ-NFSLINENQSLKKNISALIKTARVEINRK-DEEISNLHQRLS----EFP 144 ++K+ E ++ ++S +E S++ SA K + ++ R +++ N + S E P Sbjct: 795 VRKYSESRSSLDYSSDSEQSSVQATQSAQEKEKQGQMERTHNKQEKNRGEEKSKSERECP 854 Query: 145 HFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHRAKSDVSKDVHHSTSLPNLEKEGKP 204 H + D ++ R + ++ ++ DV+K+ + + + ++EG+ Sbjct: 855 HSKKRTLKENLSDHLRNGSKPKRKNYAGSKWDSESNSERDVTKNSKNDSHPSSDKEEGEA 914 Query: 205 HSDKRS-----------TSHLPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDIRHS 253 SD S T+ T+ NG W S + +S DS +S Sbjct: 915 TSDSESEVSEIHIKVKPTTKSSTNTSLPDDNGAWKSSK----QRTSTSDS---EGSCSNS 967 Query: 254 QFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDY 313 + NRG + K H K T+ K K D + Sbjct: 968 ENNRGKPQKHK----------------------HGSKENLKREHTKKVKEKLKGKKDKKH 1005 Query: 314 KGERINSSWEKETP---GERSHSRVDSQ---SDKKLERQSERSQNINRKEVKSQDKEERK 367 K + ++ + P GE +D + + K ++ SE ++ I +K++ E Sbjct: 1006 KAPKRKQAFHWQPPLEFGEEEEEEIDDKQVTQESKEKKVSENNETIKDNILKTEKSSEED 1065 Query: 368 VDQKPKSVVKDQD 380 + K +V D Sbjct: 1066 LSGKHDTVTVSSD 1078 >gi|239747174 PREDICTED: hypothetical protein XP_002343931, partial [Homo sapiens] Length = 213 Score = 58.9 bits (141), Expect = 5e-08 Identities = 38/200 (19%), Positives = 92/200 (46%), Gaps = 2/200 (1%) Query: 323 EKETPGERSHSRVDSQSDKKLERQSERSQNINR-KEVKSQDKEERKVDQKPKSVVKDQDH 381 E +T G +H+ ++ D++ ER+ E + +R KE K++D+ + Q+ + +++D Sbjct: 2 ESKTEGRHTHTETETM-DRQRERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDR 60 Query: 382 WRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSR 441 R E+ + + + + + ER ++ + D+ + + + + R Sbjct: 61 DREREKQTDREGERQRERERDRDRQRETERERDKERETDRHTETDRERQKQKEREMERVR 120 Query: 442 THKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTN 501 + KE+ Q + + + E +R+ +E K E+RH E+ E +K Sbjct: 121 DREREKQKEMGRERQTDRETDRERERQAERERETGRERKTEDRHRERERERKRERERKRE 180 Query: 502 KETKKTTTDLKKQNEPKTDK 521 + ++ TD++++ + +TD+ Sbjct: 181 TKERERHTDMERERQRETDR 200 >gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] Length = 245 Score = 57.8 bits (138), Expect = 1e-07 Identities = 43/201 (21%), Positives = 88/201 (43%), Gaps = 10/201 (4%) Query: 323 EKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHW 382 +KE ER R + + K+ ER+ ER + +KE K + K+E + +K + ++++ Sbjct: 52 KKERESERKKERREREKRKR-EREKERKRERGKKEKKGERKKEERERKKRRREKENKEGE 110 Query: 383 RRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRT 442 + +R + T + EER+ E +R++ + R R Sbjct: 111 EKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERER---KERKKRE 167 Query: 443 HKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNK 502 K + KE + + K ER+R E K++RE++ + E + R +K ++ + Sbjct: 168 RKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKE------ERKKE 221 Query: 503 ETKKTTTDLKKQNEPKTDKGE 523 K T+ +++ K ++ E Sbjct: 222 RQKDRQTNWREKERGKRERKE 242 Score = 47.0 bits (110), Expect = 2e-04 Identities = 37/159 (23%), Positives = 68/159 (42%), Gaps = 17/159 (10%) Query: 236 EGSSNEDSRRGRKDIRHSQFNRGTERVR------KDLSTGCGDGEPRILEASQRLQGHPE 289 +G ++ R +K R + G E+ + K+ +G+ R + ++ + E Sbjct: 87 KGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKE 146 Query: 290 KYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSER 349 + K E + + + K + + GE+ EKE + R + ER+ ER Sbjct: 147 RERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRER------NRKERKKER 200 Query: 350 SQNINRKEVKSQDKEERKVDQKPKSVVKD-QDHWRRSER 387 RKE + + KE +K +++ K KD Q +WR ER Sbjct: 201 ----ERKERRERKKERKKKEERKKERQKDRQTNWREKER 235 Score = 45.8 bits (107), Expect = 4e-04 Identities = 48/215 (22%), Positives = 84/215 (39%), Gaps = 13/215 (6%) Query: 218 VEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRI 277 + K CT W ++ E ++R+ K R S+ R ER ++ + E + Sbjct: 25 ISKPCTQPGWQS---EIREREREIETRKEGKKERESE--RKKERREREKRKREREKERK- 78 Query: 278 LEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDS 337 R +G EK KGE K E + K + + +GE +KE S+ Sbjct: 79 -----RERGKKEK--KGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGK 131 Query: 338 QSDKKLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEI 397 + ++K ER+ E + RK+ + + + ERK +K + + R E+ K E Sbjct: 132 ERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRER 191 Query: 398 TFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGR 432 + +ERR + ++ K Q R Sbjct: 192 NRKERKKERERKERRERKKERKKKEERKKERQKDR 226 Score = 42.0 bits (97), Expect = 0.006 Identities = 33/127 (25%), Positives = 52/127 (40%), Gaps = 1/127 (0%) Query: 241 EDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTES 300 E RGR + R ER R++ E R E ++ + E+ GE + E Sbjct: 119 EKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEER 178 Query: 301 KSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKS 360 K + K + + E++ ER R + KK ERQ +R N KE Sbjct: 179 KEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKK-ERQKDRQTNWREKERGK 237 Query: 361 QDKEERK 367 ++++ERK Sbjct: 238 RERKERK 244 Score = 36.2 bits (82), Expect = 0.33 Identities = 24/100 (24%), Positives = 46/100 (46%), Gaps = 4/100 (4%) Query: 457 WENTPLKAERH---RTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKK 513 W++ + ER R E K++RE E K+E R R +++ E +K + K+ + KK Sbjct: 34 WQSEIREREREIETRKEGKKERESERKKERRE-REKRKREREKERKRERGKKEKKGERKK 92 Query: 514 QNEPKTDKGEVLDNGVSEGADNKELAMKAESGPNETKNKD 553 + + + +N E + ++ K E G + K+ Sbjct: 93 EERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKE 132 Score = 35.4 bits (80), Expect = 0.56 Identities = 24/93 (25%), Positives = 44/93 (47%), Gaps = 2/93 (2%) Query: 463 KAERHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKG 522 K ER R +KRKRE+E + + + EK+ + ++ K+ ++ + + + + K K Sbjct: 60 KKER-REREKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKK 118 Query: 523 EVLDNGVSEGADNKELAMKAESGPNETKNKDLK 555 E + G + KE K E E K ++ K Sbjct: 119 EKKERG-RTSKEGKERERKEERKREERKERERK 150 >gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] Length = 1020 Score = 57.4 bits (137), Expect = 1e-07 Identities = 94/498 (18%), Positives = 176/498 (35%), Gaps = 64/498 (12%) Query: 165 KSRSPHLDDCSKTDHRAKSDVSKDVHHSTSLPNLEKE-----------GKPHSDKRSTSH 213 +++SP ++ + + AKS V ++ + EKE K S + + Sbjct: 500 ETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAK 559 Query: 214 LPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDG 273 P + S + + E + + + + V+++ + Sbjct: 560 SPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAK 619 Query: 274 EPRILEASQRLQGHPEKYGKGEPKTESKS-SKFKSNSDSDYKG-ERINSSWEKETPG-ER 330 P EA + + K K E+KS K KS + K E+ S + E E+ Sbjct: 620 SPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEK 679 Query: 331 SHSRVDSQSD---------KKLERQSERSQNINRKEVKSQD------KEERKVDQKPKSV 375 + S V +++ K+ + E++++ ++E KS + KEE K +K KS Sbjct: 680 AKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSP 739 Query: 376 VKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRG--------------WEDCKRDK 421 VK++ + E+A P + +K +E E+ K + Sbjct: 740 VKEEA--KSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPE 797 Query: 422 SVNSHSFQDGRCP-----------SSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTE 470 S +D + P S + + + KE + E P + + Sbjct: 798 KAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKK 857 Query: 471 DKRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVS 530 D +K E KE + EK+ P K +K K K+ P +K V Sbjct: 858 DSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVK 917 Query: 531 EGADNKELAMKAESGPNETKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITDIPKSSG 590 E A KE A+ P++ K K+ KK + P +D + + P+ Sbjct: 918 EDAKPKEKTEVAKKEPDDAKAKEPSKPAEKK--------EAAPEKKDTKEEKAKKPEEKP 969 Query: 591 VCDSESSMQVKTVAYVPS 608 ++++ KT++ PS Sbjct: 970 KTEAKAKEDDKTLSKEPS 987 Score = 45.8 bits (107), Expect = 4e-04 Identities = 91/493 (18%), Positives = 169/493 (34%), Gaps = 40/493 (8%) Query: 199 EKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRG 258 E EG K + S EK + V + S ++ + +++ + + Sbjct: 493 EAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPE--KA 550 Query: 259 TERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTESKS---SKFKSNSDSDYKG 315 +++ + P EA + + K K E+KS +K + S K Sbjct: 551 KSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKE 610 Query: 316 ERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKSQDKEERKVDQKPKSV 375 E + + K E + S + +S +K + ++ K KS +KEE K +K KS Sbjct: 611 EAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEK-AKSPEKEEAKSPEKAKSP 669 Query: 376 VKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPS 435 VK + + E+A P K E + EE + E K + S + + P Sbjct: 670 VKAEA--KSPEKAKSP-VKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPV 726 Query: 436 SLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESKEENRHIRNEKRVPTE 495 + K + + +P KA+ E + + +S E + E R P + Sbjct: 727 -----KEEAKTPEKAKSPVKEEAKSPEKAKS--PEKAKTLDVKSPEAKTPAKEEARSPAD 779 Query: 496 HL-QKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAMKAESGPNETKNKDL 554 +K K+ +K P + + + + + + K +K E P E K Sbjct: 780 KFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKS-PVKEEEKPQEVK---- 834 Query: 555 KLSFMKKLNLTLSPAKKQPVSQDNQHKITDIPKSSGVCDSESSMQVKTVAYVPSISEHIL 614 K+P + + K PK+ DS+ K A P + E Sbjct: 835 ---------------VKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKE 879 Query: 615 GEAAVSEHTMGETKSTLLEPKVALLAVTE---PRIGISETNKEDENSLLVRSVDNTMHCE 671 + + E K E K + + ++ + E K E + + + + + Sbjct: 880 PAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAK 939 Query: 672 EPICGTETSFPSP 684 EP E +P Sbjct: 940 EPSKPAEKKEAAP 952 Score = 43.9 bits (102), Expect = 0.002 Identities = 86/427 (20%), Positives = 158/427 (37%), Gaps = 32/427 (7%) Query: 272 DGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERS 331 +G P+I S ++ E+ K K+E ++ + ++ E + EKE E Sbjct: 424 EGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEG 483 Query: 332 HSRVDSQSDKKLERQSERSQN-------INRKEVKSQDKEERKVDQKPKSVVKDQ----D 380 + +++ E E +++ KE KS KEE K + KS K++ Sbjct: 484 KEE-EGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPA 542 Query: 381 HWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNS 440 + E+A P +K E + EE + + K + S + ++ + P+ + Sbjct: 543 EVKSPEKAKSP-AKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSP 601 Query: 441 RTHKNIDSKEVDAMHQWENTPLKAER---------HRTEDKRKREQESKEENRHIRNEKR 491 K+ +E + + +P+K E + + K E +S E+ + E+ Sbjct: 602 EKAKSPVKEEAKSPAE-AKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEA 660 Query: 492 VPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAMKAESG-PNETK 550 E + K K+ K + + E + V E A + E KA+S E K Sbjct: 661 KSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPE---KAKSPVKEEAK 717 Query: 551 NKDLKLSFMKKLNLTLSPAK---KQPVSQDNQHKITDIPKSSGVCDSESSMQVKTVAYVP 607 + + S +K+ T AK K+ + K + K+ V E+ K A P Sbjct: 718 SPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSP 777 Query: 608 SISEHILGEAAVSEHTMG--ETKSTLLEPKVALLAVTEPRIGISETNKEDENSLLVRSVD 665 + ++ V E + KS L E A + + KE+E V+ + Sbjct: 778 ADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKE 837 Query: 666 NTMHCEE 672 EE Sbjct: 838 PPKKAEE 844 Score = 40.8 bits (94), Expect = 0.013 Identities = 50/259 (19%), Positives = 100/259 (38%), Gaps = 25/259 (9%) Query: 288 PEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLE--- 344 PE + + S + KF + S K E + S + ++P + + + KK E Sbjct: 764 PEAKTPAKEEARSPADKFPEKAKSPVK-EEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKS 822 Query: 345 --RQSERSQNINRKEVKSQDKEER---------KVDQKPKSVVKDQDHWRRSERASLPHS 393 ++ E+ Q + KE + +EE+ K D K + K + + E P Sbjct: 823 PVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAV 882 Query: 394 KNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDA 453 + + K E+++ +++ +D + P + + D+K + Sbjct: 883 EKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAK-PKEKTEVAKKEPDDAKAKEP 941 Query: 454 MHQWENTPLKAERHRT--------EDKRKREQESKEENRHIRNEKRVP-TEHLQKTNKET 504 E E+ T E+K K E ++KE+++ + E P E +K++ Sbjct: 942 SKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTD 1001 Query: 505 KKTTTDLKKQNEPKTDKGE 523 +K + +K E K KG+ Sbjct: 1002 QKDSKPPEKATEDKAAKGK 1020 Score = 35.8 bits (81), Expect = 0.43 Identities = 98/498 (19%), Positives = 170/498 (34%), Gaps = 69/498 (13%) Query: 1461 PDMSSSSTPEEVISAHFSEDALLEEEDASEQDIHLALESDNSSSKSSCSSSWTSRSVAPG 1520 P +++PE+ + E+A E S E + + S + S ++S A Sbjct: 504 PPAEEAASPEKEAKSPVKEEAKSPAEAKSP-------EKEEAKSPAEVKSPEKAKSPA-- 554 Query: 1521 FQYHPNLPMHAVIMEKSNDHFIVKIRRATPSTSSGLKQSMMPDELLTSLPRHGKEADEGP 1580 + P A EK +++ + S +++ P E + E + P Sbjct: 555 -KEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSP------EKAKSP 607 Query: 1581 EKEYISCQNTVFKSVEELENSN---KNVDGSKS-THEEQSSMIQTQVPDIYEFLKDASDK 1636 KE V+E S K+ + +KS T EE S + + P+ E K Sbjct: 608 VKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAK 667 Query: 1637 MGHSDEV-ADECFKLHQVWETKVPESI-----EELPSMEEISHSVGEHLPNTYVDLTKDP 1690 E + E K E K PE EE S E+ V E + + K P Sbjct: 668 SPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSP--EKAKSP 725 Query: 1691 VTETKNLGEFIEVTVLHIDQLGCSGGNLNQSAQILDNSLQADTVGAFIDLTQDASSEAKS 1750 V E E + V + A+ + + + + +A + AK Sbjct: 726 VKEEAKTPEKAKSPV-------------KEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKE 772 Query: 1751 EGNHPALAVEDLGCGVIQVDEDNCKEEKAQV---ANRPLKCIVEETYIDLTTESPSSCEV 1807 E PA + ++ + + ++ K+ + A P K I ++ + +SP E Sbjct: 773 EARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEV----KSPVKEEE 828 Query: 1808 KKDELK-SEPGSNCDNSELPGTLHNSHKK-------------RRNISDLNHP-------H 1846 K E+K EP + + P T KK + + + P Sbjct: 829 KPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKES 888 Query: 1847 KKQRKETDLTNKEKTKKPTQDSCENTEAHQKKASKKKAPPVTKDPSSLKATPGIKDSSAA 1906 K + K+ + +K+K P +++ E + K+K K+P KA K + Sbjct: 889 KVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKK 948 Query: 1907 LATSTSLSAKNVIKKKGE 1924 A K KK E Sbjct: 949 EAAPEKKDTKEEKAKKPE 966 Score = 34.7 bits (78), Expect = 0.95 Identities = 136/748 (18%), Positives = 249/748 (33%), Gaps = 79/748 (10%) Query: 302 SSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKSQ 361 S K N+D+ + + + ++ + + LERQ ++ ++ ++ S Sbjct: 301 SEAAKVNTDAMRSAQEEITEYRRQLQARTTELEALKSTKDSLERQRSELEDRHQADIASY 360 Query: 362 DKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRDK 421 + +++D + ++ + R E L + K + + + LE E+C+ Sbjct: 361 QEAIQQLDAELRNTKWEMAAQLR-EYQDLLNVKMALDIEIAAYRKLLEG----EECRIGF 415 Query: 422 SVNSHSFQDGRCPSSLSNSRTHKNIDSKE------------VDAMHQWENTPLKAERHRT 469 S +G + + TH + S+E V Q E T + E Sbjct: 416 GPIPFSLPEGL--PKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEE 473 Query: 470 EDKRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGV 529 E+K +E+E KE E+ E + +ETK + + P+ + + Sbjct: 474 EEKEAKEEEGKE-------EEGGEEEEAEGGEEETKSPPAE--EAASPEKEAKSPVKEEA 524 Query: 530 SEGADNKELAMKAESGPNETKNKDLKLSFMKKLNLTLSPAK---KQPVSQDNQHKITDIP 586 A+ K + P E K+ + S K+ + AK K+ + K + Sbjct: 525 KSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKA 584 Query: 587 KSSGVCDSESSMQVKTVAYVPSISEHILGEAAVSEHTMGETKSTLLEPKVALLAVTEPRI 646 KS +++S + K+ P ++ + E A S E KS + E + V P Sbjct: 585 KSPAKEEAKSPAEAKS----PEKAKSPVKEEAKSP---AEAKSPVKEEAKSPAEVKSPEK 637 Query: 647 GISETNKEDENSLLVRSVDNTMHCEEPICGTETSFPSPMEIQQTESLFPSTGMKQTINNG 706 S T +E +S + E+ + SP++ + + +K + Sbjct: 638 AKSPTKEE------AKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSP 691 Query: 707 RAAAPVVMDVLQTDVSQNFGLELDTKRNDNSDYCGISEGMEMKVALSTTVSETTESILQP 766 A V + ++ ++ + K + + E + A S E Sbjct: 692 EKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAK 751 Query: 767 SIEEADILPIMLSEDNNPKFEPSVIVTPLVESKSCHLEPCLPKETLDSSLQQTELMDHRM 826 S E+A L + E P E + K+ KE + S + + Sbjct: 752 SPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKA----KSPVKEEVKSPEKAKSPLKEDA 807 Query: 827 ATGETNSVYHDDDNSVLSIDLNHLRPIPEAISPLNSPVRPVAKVLRNESPPQVP--VYNN 884 E ++ S P+ E P V+ K E P P Sbjct: 808 KAPEKEIPKKEEVKS----------PVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKK 857 Query: 885 SHKDVFLPNSAHSTSKSQSDLNKENQKPIYK--SDKCTEADTCKNSPLDELEEGEIRSDS 942 K P K + +KP K EA+ K P E E Sbjct: 858 DSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVK 917 Query: 943 ETSKPQESFEKNSKRRVSADVRKSKTIPRRGKSTVCLDKDSR-----------KTHVRIH 991 E +KP+E E K A K + P K KD++ KT + Sbjct: 918 EDAKPKEKTEVAKKEPDDAKA-KEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAK 976 Query: 992 QTNNKWNKRP-----DKSSRSSKTEKKD 1014 + + +K P +K+ +SS T++KD Sbjct: 977 EDDKTLSKEPSKPKAEKAEKSSSTDQKD 1004 Score = 32.7 bits (73), Expect = 3.6 Identities = 37/151 (24%), Positives = 57/151 (37%), Gaps = 22/151 (14%) Query: 1770 DEDNCKEEKAQVANRPLKCIVEETYIDLTTESPSSCEVKKDELKSEPGSNCDNSELPGTL 1829 ++ + K+E+A P + E+ + S E KK+E + + E P + Sbjct: 855 EKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKV 914 Query: 1830 HNSH-----------KKRRNISDLNHPHKKQRK-----ETDLTNKEKTKKPTQDSCENTE 1873 KK + + P K K E T +EK KKP + TE Sbjct: 915 EVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEK--PKTE 972 Query: 1874 AHQKKASKKKAPPVTKDPSSLKATPGIKDSS 1904 A K+ K ++K+PS KA K SS Sbjct: 973 AKAKEDDK----TLSKEPSKPKAEKAEKSSS 999 >gi|50962882 G patch domain containing 8 [Homo sapiens] Length = 1502 Score = 57.4 bits (137), Expect = 1e-07 Identities = 77/319 (24%), Positives = 121/319 (37%), Gaps = 27/319 (8%) Query: 194 SLPNL-EKEGKPHSDKRSTSHLPTS--VEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDI 250 SLP+ E+ GK H K+ H +S KH + S + GE S R+ +K+ Sbjct: 661 SLPSKKERSGKSHRHKKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRKKN- 719 Query: 251 RHSQFNRGTERVRKDLSTGCGDGEP-----RILEASQRLQGHPEKYGKGEPKTESKSSKF 305 S +ER K G G P R + SQR E+ G+ S Sbjct: 720 -KSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSS 778 Query: 306 KSNSDSDYKGERINSSWEKETPGER----SHSRVDSQSDKKLERQSERSQNINRKEVKSQ 361 + + +KGE SS ++ +R SH S D+ + S S +++K Sbjct: 779 QDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDAS--SHRLHQKSPSQY 836 Query: 362 DKEERKVD-------QKPKSVVKDQDH--WRRSERASLPHSKNEITFSHNSSKYHLEERR 412 +EE + D + +S + H RRS +S S ++ +S S Y + Sbjct: 837 SEEEEEEDSGSEHSRSRSRSGRRHSSHRSSRRSYSSSSDASSDQSCYSRQRS-YSDDSYS 895 Query: 413 GWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDK 472 + D R S SH D SS S+ HK S + D + ++ H E Sbjct: 896 DYSDRSRRHSKRSHDSDDSDYASSKHRSKRHK-YSSSDDDYSLSCSQSRSRSRSHTRERS 954 Query: 473 RKREQESKEENRHIRNEKR 491 R R + R+++R Sbjct: 955 RSRGRSRSSSCSRSRSKRR 973 Score = 42.0 bits (97), Expect = 0.006 Identities = 56/268 (20%), Positives = 100/268 (37%), Gaps = 30/268 (11%) Query: 166 SRSPHLDDCSKTDHRAKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNG 225 SRS H S D + S +H + E+E + S + S +H ++ Sbjct: 805 SRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHR 864 Query: 226 VWSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQ 285 RS+ + SS++ ++ ++ ++R R+ + + R + Sbjct: 865 SSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSK 924 Query: 286 GHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLER 345 H KY S+SD DY + S + RSH+R S+S R Sbjct: 925 RH--KY---------------SSSDDDY-----SLSCSQSRSRSRSHTRERSRS-----R 957 Query: 346 QSERSQNINRKEVKSQDKEERKVD-QKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSS 404 RS + +R K + + Q+ +S +D+ RS S + ++ H S Sbjct: 958 GRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRS--PSQRSGSRKRSWGHESP 1015 Query: 405 KYHLEERRGWEDCKRDKSVNSHSFQDGR 432 + RR + K +S + H F+ GR Sbjct: 1016 EERHSGRRDFIRSKIYRSQSPHYFRSGR 1043 Score = 39.3 bits (90), Expect = 0.039 Identities = 62/282 (21%), Positives = 98/282 (34%), Gaps = 27/282 (9%) Query: 130 DEEISNLHQRL-SEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHRAKSDVSKD 188 D LHQ+ S++ + +++ + S H S+ + + SD S D Sbjct: 822 DASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRS--SRRSYSSSSDASSD 879 Query: 189 VHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSNEDS----- 243 + + + RS H S + ++ S+ + + SS++D Sbjct: 880 QSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSC 939 Query: 244 ----RRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTE 299 R R R +RG R S+ C R S+ H + + + Sbjct: 940 SQSRSRSRSHTRERSRSRGRSR-----SSSCS--RSRSKRRSRSTTAHSWQRSRSYSRDR 992 Query: 300 SKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVK 359 S+S++ S S G R SW E+P ER R D K QS R E Sbjct: 993 SRSTR----SPSQRSGSR-KRSWGHESPEERHSGRRDFIRSKIYRSQSPHYFRSGRGEGP 1047 Query: 360 SQDKEERKVDQK---PKSVVKDQDHWRRSERASLPHSKNEIT 398 + + R D K P S + R SE P KN +T Sbjct: 1048 GKKDDGRGDDSKATGPPSQNSNIGTGRGSEGDCSPEDKNSVT 1089 Score = 33.5 bits (75), Expect = 2.1 Identities = 26/86 (30%), Positives = 42/86 (48%), Gaps = 5/86 (5%) Query: 1800 ESPSSCEVKKDELKSEPG-SNCDNSELPGTLHNSHKKRRNISDLNHPHKKQRKETDLT-N 1857 ++P+S K EPG S+ +E G S K+R S +H HKK++K + + Sbjct: 631 DAPASGSACSGLNKQEPGGSHGSETEDTGRSLPSKKER---SGKSHRHKKKKKHKKSSKH 687 Query: 1858 KEKTKKPTQDSCENTEAHQKKASKKK 1883 K K K T++ E+ +K +KK Sbjct: 688 KRKHKADTEEKSSKAESGEKSKKRKK 713 >gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like [Homo sapiens] Length = 899 Score = 57.0 bits (136), Expect = 2e-07 Identities = 85/498 (17%), Positives = 198/498 (39%), Gaps = 37/498 (7%) Query: 59 EEILTEEGTAKEATYNDLQVEYGKCQLQMKELMKKFKEIQTQNFSLINENQSLKKNISAL 118 EE + E+ ++ + K Q + L ++ K+++ Q + ++ + + + L Sbjct: 347 EEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERL 406 Query: 119 IKTARVEINRKDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKD--LKSRSPHLDDCSK 176 + + E R+ E++ +++ E + K R + ++ ++ R + + + Sbjct: 407 RE--KEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEE 464 Query: 177 TDHRAKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGE 236 T + + K + E+E K +R LP EK +W + Q E Sbjct: 465 TMREQEEKMQKQEENMW-----EQEEKEWQQQR----LPEQKEK-----LWEQEKMQEQE 510 Query: 237 GS--SNEDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKG 294 E+ R ++++ + + ++ + E ++ + Q++ E+ Sbjct: 511 EKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERM--- 567 Query: 295 EPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNIN 354 E KT+ + K + + ER+ +K E + + ++ E+ E+ + + Sbjct: 568 EKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMW 627 Query: 355 RKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSH----NSSKYHLEE 410 +E K Q++EE+ +Q+ K +++ W E+ LP K ++ + H K +E Sbjct: 628 EQEEKMQEQEEKMWEQEEKMWEQEEKMW---EQQRLPEQKEKL-WEHEKMQEQEKMQEQE 683 Query: 411 RRGWEDCKRDKSVNSH---SFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERH 467 + WE K +K ++ + S K + +E Q E + E+ Sbjct: 684 EKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKM 743 Query: 468 RTEDKRKREQESK--EENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVL 525 + +++ EQE K E+ + ++R+P + + E + + +Q E D+ E + Sbjct: 744 QEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKM 803 Query: 526 DNGVSEGADNKELAMKAE 543 G E +E M+ + Sbjct: 804 -RGQEEKMRGQEEKMRGQ 820 Score = 56.6 bits (135), Expect = 2e-07 Identities = 49/249 (19%), Positives = 101/249 (40%), Gaps = 24/249 (9%) Query: 274 EPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHS 333 E + E ++++ EK + E + + K + + ++ E+ EKE Sbjct: 278 EEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKEL------- 330 Query: 334 RVDSQSDKKLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHS 393 + +K+L Q E + +E + Q++EE+ +Q+ K +++ WR+ ER Sbjct: 331 ---REQEKELREQKE----LREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERL----W 379 Query: 394 KNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKE--- 450 + E K +E R WE +R + + + + R K + +E Sbjct: 380 EQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKT 439 Query: 451 ---VDAMHQWENTPLKAERHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKT 507 + M + E + ++ R E++ REQE K + + ++ E Q+ E K+ Sbjct: 440 RDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEK 499 Query: 508 TTDLKKQNE 516 + +K E Sbjct: 500 LWEQEKMQE 508 Score = 43.1 bits (100), Expect = 0.003 Identities = 48/293 (16%), Positives = 110/293 (37%), Gaps = 53/293 (18%) Query: 274 EPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGE-----RINSSWEKETPG 328 E +I E ++++ E +G + K + K + D ++ E + W++E Sbjct: 510 EEKIWEQEEKIRDQEEMWG--QEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQE--- 564 Query: 329 ERSHSRVDSQSDK---------KLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQ 379 ER + Q K + ER ER + + +E +++EE+ +Q+ K +++ Sbjct: 565 ERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEE 624 Query: 380 DHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSN 439 W + E K +E + WE ++ ++ R P Sbjct: 625 KMWEQEE------------------KMQEQEEKMWEQEEKMWEQEEKMWEQQRLP----- 661 Query: 440 SRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESKEENRHIRNEKRVPTEHLQK 499 + KE WE+ ++ + E + K ++ K E + EK+ + + Sbjct: 662 -------EQKE----KLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMR 710 Query: 500 TNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAMKAESGPNETKNK 552 + ++ ++++ E ++ E + + + +E + E E + K Sbjct: 711 EEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEK 763 Score = 32.3 bits (72), Expect = 4.7 Identities = 27/106 (25%), Positives = 55/106 (51%), Gaps = 12/106 (11%) Query: 1117 DRLFEQQ-LPDMKKKLWKFVDDQLDYLFAKLKKILVCDSKSFGRDSDEGKLEKTSKQNAQ 1175 ++++EQQ LP+ K+KLW+ Q + +K+ + K + ++ E +KT +Q + Sbjct: 652 EKMWEQQRLPEQKEKLWEHEKMQ------EQEKMQEQEEKIWEQEKME---KKTQEQEKK 702 Query: 1176 YSNSQKRSVDNSNRELLKEKLSKSEDPVHYKSLVGCKKSEENYQDQ 1221 + +K + S RE +EK + E+ + + ++ EE Q+Q Sbjct: 703 TWDQEKMREEESMRE--REKKMREEEEMMREQEEKMQEQEEKMQEQ 746 >gi|71061468 centromere protein E [Homo sapiens] Length = 2701 Score = 56.2 bits (134), Expect = 3e-07 Identities = 246/1253 (19%), Positives = 479/1253 (38%), Gaps = 186/1253 (14%) Query: 194 SLPN-LEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDIRH 252 SLP+ +E+ K DK H+ TS + + V H + E+ + + D+ Sbjct: 751 SLPSEVERLRKEIQDKSEELHIITSEKDKLFSEV---VHKESRVQGLLEEIGKTKDDLAT 807 Query: 253 SQFN-RGTERVRKDLSTGCGDGEPR---ILEASQRLQGHPEKYGKGEPKTESKSSKFKSN 308 +Q N + T++ ++ T D E + +LE ++R+ K K +S K+ Sbjct: 808 TQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKT- 866 Query: 309 SDSDYKG-----------ERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKE 357 + YK ER+N + + E S + + +K + Q + + Sbjct: 867 -ELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVK 925 Query: 358 VKSQDKEERKVDQKPKSVVKD----------------QDHWRRSERASLPHSKNEITFSH 401 +Q+K++ K Q+ + +D Q+ R + + H + T Sbjct: 926 TLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKS 985 Query: 402 N-----SSKYHLEERRG-WEDCKRDKSVNSHSFQDGRCPSS------------LSNSRTH 443 S H+EE G +D + K V QD ++ + R Sbjct: 986 KISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKI 1045 Query: 444 KNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQ--ESKEENRHIRNEKRVPTE------ 495 ++ ++ + E+ + E+ +T+ K E E++EE R + +E + E Sbjct: 1046 FSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEK 1105 Query: 496 --------HLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAMKAESGPN 547 L +T + LK++++ +K + L N E ++ ++ + E+ N Sbjct: 1106 NHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKN 1165 Query: 548 ETKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITDIPKSSGVC-DSESSMQVKTVAYV 606 E KNK+L L M+ L L+ +N ++ I K V + + S + + Sbjct: 1166 ELKNKELTLEHMETERLELAQK-----LNENYEEVKSITKERKVLKELQKSFETE----- 1215 Query: 607 PSISEHILGEAAVSEHTMGETKSTLLEPKVALL----AVTEPRIGISETNKEDENSLLVR 662 +H+ G E T +TK L + L + E R +SE + N+ + Sbjct: 1216 ---RDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLE 1272 Query: 663 SVDNTMHCEEPICGTETS-FPSPMEIQQTESLFPSTGM---KQTINNGRAAAPVVMDVLQ 718 + E P+ E P+ E+ +T+ + + T + A + M+ L+ Sbjct: 1273 KSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLR 1332 Query: 719 -TDVSQNFGLELDTKRNDNSDYCGISEGMEMK-VALSTTVSETTESILQPSIEEADILPI 776 + Q E+ + + + I E +E+K L + ET I + ++ L Sbjct: 1333 LNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLN- 1391 Query: 777 MLSEDNNPKFEPSVIVTPLVESKSCHLEPCLPKETLDSSLQQTELMDHRMATGETNSVYH 836 M +DN E + IV+ + + K PK DS+L + E+ + + H Sbjct: 1392 MKEKDN----ETTKIVSEMEQFK--------PK---DSALLRIEI--EMLGLSKRLQESH 1434 Query: 837 DDDNSVL--SIDLNHLRPIPEAIS-PLNSPVRP-VAKVLRNESPPQVPVYNNSHKDVFLP 892 D+ SV DL L+ + ++ S L ++ VAK L E +V Sbjct: 1435 DEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKV------------- 1481 Query: 893 NSAHSTSKSQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFE 952 AH K Q + N+ + S+K TE T + L+ + + E + +E F Sbjct: 1482 --AHCCLKEQEE--TINELRVNLSEKETEISTIQKQ-LEAINDKLQNKIQEIYEKEEQFN 1536 Query: 953 KNSKRRVSADVRKSKTIP--RRGKSTVCLDKDSRKTHV--RIHQTNNKWNKRPDKSSRSS 1008 V V + K R+ K + +S+ + R+ ++ + + Sbjct: 1537 IKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMK 1596 Query: 1009 KTEKKDKVMSTSSLEKIVPIIA-VPSSEQEIMHMLRMIRKHVRKNYM----KFKAKFSLI 1063 + ++ ++ E I+A + S+++ L+M + + M K +F Sbjct: 1597 RVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQ 1656 Query: 1064 QFH-RIIESAILSFTSLIKHLNLHKISKSVTTLQKNLCDIIESKLKQVKKNGIVDRLFEQ 1122 + + IE+ + T ++ H NL ++ +SVT + +L + E+ +V+++ + + L E Sbjct: 1657 KLNLENIETENIRLTQIL-HENLEEM-RSVTKERDDLRSVEET--LKVERDQLKENLRET 1712 Query: 1123 QLPDMKKKLWKFVDDQLDYLFAKLKKILVCDSKSFGRDSDEGKLEKTSKQNAQYSNSQKR 1182 D++K+ ++L + LK+ K G S EKT+ + SN QK Sbjct: 1713 ITRDLEKQ------EELKIVHMHLKEHQETIDKLRGIVS-----EKTN----EISNMQK- 1756 Query: 1183 SVDNSNRELLKEKLSKSED----PVHYKSLVGCKKSEENYQDQNNSSINTVKHDIKKNFN 1238 +++SN L + L E+ +H K + ++ ++ D++ + Sbjct: 1757 DLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNA 1816 Query: 1239 ICFDNIKNSQSEERSLEVHCPSTPKSEKNEGSSIEDAQTSQHATLKPERSFEILTEQQAS 1298 + I+ ++ E L T K + NE + S+ LK + + LT + Sbjct: 1817 KLQEKIQELKANEHQL-----ITLKKDVNE----TQKKVSEMEQLKKQIKDQSLTLSKLE 1867 Query: 1299 SLTFNLVSDAQMG-EIFKSLLQGSDLLDSSVNCTEKSEWELKTPEKQLLETLK 1350 NL E KS+++ D L + E LK QL E+L+ Sbjct: 1868 IENLNLAQKLHENLEEMKSVMKERDNL-------RRVEETLKLERDQLKESLQ 1913 Score = 47.0 bits (110), Expect = 2e-04 Identities = 191/1053 (18%), Positives = 388/1053 (36%), Gaps = 138/1053 (13%) Query: 87 MKELMKKFKEIQTQNFSLINENQSLKKNISALIKTARVEINRKDEEISNLHQRLSEFPHF 146 +K+L + + + Q S I++ ++ + ++ A + + E I+ L ++SE Sbjct: 934 LKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVS- 992 Query: 147 RNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHRAKSDVSKDVHHSTSLPNLEKEGKPHS 206 RN H T +T + + + +D + + ++ DV + + K Sbjct: 993 RNLHMEENTGET--KDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQ 1050 Query: 207 DKRSTSHLPTSV--EKHCTNGVWSRSHYQVGEGSSN----EDSRRGRKDIRHSQFNRGTE 260 +K + SV EK + E D + +++I + N + Sbjct: 1051 EKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIK 1110 Query: 261 RVRKDLSTGC---GDGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGER 317 + +LS C + E ++ E SQ+LQ E + + ++ Sbjct: 1111 K-EGELSRTCDRLAEVEEKLKEKSQQLQ-------------EKQQQLLNVQEEMSEMQKK 1156 Query: 318 INSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVK 377 IN + + ++ ++LE + ++N +EVKS KE + + + KS Sbjct: 1157 INEIENLKNELKNKELTLEHMETERLELAQKLNENY--EEVKSITKERKVLKELQKSFET 1214 Query: 378 DQDHWR---RSERASLPHSKNEITFSHNSSKYH---LEERRGWEDCKRDKSVN------S 425 ++DH R R A+ +K E+ +H K H ++E R K + +N S Sbjct: 1215 ERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKS 1274 Query: 426 HSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWEN-TPLKAERHRTEDK------------ 472 H+ P N+ KEV + N L E+ T+D Sbjct: 1275 HTKLQEEIPVLHEEQELLPNV--KEVSETQETMNELELLTEQSTTKDSTTLARIEMERLR 1332 Query: 473 -RKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSE 531 ++ QES+EE + + E+ ++L KT KE + D K++ +T + E Sbjct: 1333 LNEKFQESQEEIKSLTKER----DNL-KTIKEALEVKHDQLKEHIRETLA------KIQE 1381 Query: 532 GADNKELAMKAESGPNET----------KNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHK 581 +E ++ + NET K KD L ++ L LS K+ S D Sbjct: 1382 SQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLS--KRLQESHDEMKS 1439 Query: 582 IT----DIPKSSGVCDSESSMQVKTVAYVPSISEHILGEAAVSEHTMGETKSTLLEPKVA 637 + D+ + V SES + + + + E V+ + E + T+ E +V Sbjct: 1440 VAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVN 1499 Query: 638 LLAVTEPRIGISETNKEDENSLLVRSVDNTMHCEEPICGTETSFPSPMEIQQTESLFPST 697 L+ E I + E N L + EE I+Q + Sbjct: 1500 -LSEKETEISTIQKQLEAINDKLQNKIQEIYEKEE-----------QFNIKQISEVQEKV 1547 Query: 698 GMKQTINNGRAAAPVVMDVLQTDVSQNFGLELDTKRNDNSD--YCGISEGMEMKVALSTT 755 + R A + +++ + LEL + ++ + I E EMK Sbjct: 1548 NELKQFKEHRKAKDSALQSIESKM-----LELTNRLQESQEEIQIMIKEKEEMKRVQEAL 1602 Query: 756 VSETTESILQPSIEEADILPIMLSEDNNPKFEPSVIVTPLVESKSCHLEPCLPK-ETLDS 814 E + L+ + +E + + S++ +F V + K C +E + ET Sbjct: 1603 QIERDQ--LKENTKEI-VAKMKESQEKEYQFLKMTAVNE-TQEKMCEIEHLKEQFETQKL 1658 Query: 815 SLQQTELMDHRMATGETNSVYHDDDNSVLSI--DLNHLRPIPEAISPLNSPVRP------ 866 +L+ E + R+ + H++ + S+ + + LR + E + ++ Sbjct: 1659 NLENIETENIRL-----TQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETI 1713 Query: 867 VAKVLRNESPPQVPVYNNSHKDV------FLPNSAHSTSKSQSDLNKENQKPIYKSDKCT 920 + + E V ++ H++ + + S Q DL N + K Sbjct: 1714 TRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQ 1773 Query: 921 EADTCKNSPLDELEE------GEIRSDSETSKPQESFEKNSKRRVSADVRKSKTIPRRGK 974 E + L E +E G + ++ + +NS ++ +++ K Sbjct: 1774 EELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKA---NEH 1830 Query: 975 STVCLDKDSRKTHVRIHQTNNKWNKRPDKSSRSSKTEKKDKVMST---SSLEKIVPIIAV 1031 + L KD +T ++ + + D+S SK E ++ ++ +LE++ ++ Sbjct: 1831 QLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKE 1890 Query: 1032 PSSEQEIMHMLRMIRKHVRKNYMKFKAKFSLIQ 1064 + + + L++ R ++++ + KA+ IQ Sbjct: 1891 RDNLRRVEETLKLERDQLKESLQETKARDLEIQ 1923 Score = 46.6 bits (109), Expect = 2e-04 Identities = 125/645 (19%), Positives = 243/645 (37%), Gaps = 116/645 (17%) Query: 37 DSAVSDSASKSCVPSRNCLDLYEEI--LTEEGTAKEATYNDLQVEYGKCQLQMKELMKKF 94 DSA+ SK + + EEI + +E + LQ+E + + KE++ K Sbjct: 1561 DSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKM 1620 Query: 95 KEIQTQNF-----SLINENQSLKKNISALIKTARVE-INRKDEEISN------LHQRLSE 142 KE Q + + + +NE Q I L + + +N ++ E N LH+ L E Sbjct: 1621 KESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEE 1680 Query: 143 F---------------------PHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHRA 181 + N + T D K ++LK HL + +T + Sbjct: 1681 MRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKL 1740 Query: 182 KSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSNE 241 + VS+ + + N++K+ + +D L E +H + E Sbjct: 1741 RGIVSE---KTNEISNMQKDLEHSNDALKAQDLKIQEELRI-------AHMHLKEQQETI 1790 Query: 242 DSRRG------------RKDIRHS--------QFNRGTERVRKDLSTGCGDGEPRILEAS 281 D RG +KD+ +S Q + E L + + ++ E Sbjct: 1791 DKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEME 1850 Query: 282 Q---RLQGHPEKYGKGEPKTESKSSKFKSNSD--SDYKGERINSSWEKET-PGERSHSRV 335 Q +++ K E + + + K N + ER N +ET ER + Sbjct: 1851 QLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKE 1910 Query: 336 DSQS----DKKLERQSERSQNINRKEVKSQDKEERKVDQK-------PKSVVKDQDHWRR 384 Q D +++++ + ++ ++++ ++ DK K+ +K K + K +D ++ Sbjct: 1911 SLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQK 1970 Query: 385 ------SERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLS 438 + L K ++ SH + ++ +E ++ S+ S + + L Sbjct: 1971 KIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFE--AQNLSMQSVRMDNFQLTKKLH 2028 Query: 439 NSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESKEENRHIRNEKRVPT---E 495 S I +KE D + + + + LK ER + + +N ++ EKR+ + + Sbjct: 2029 ESLEEIRIVAKERDELRRIKES-LKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQ 2087 Query: 496 HLQKTNKETKKTTTDLKKQNEPKTDKGEVLD----NGVSEGADNKELAMKAESGPN---- 547 HL ++ +E +L K+ D E L+ + E KEL+M+ ++ + Sbjct: 2088 HLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYL 2147 Query: 548 --------ETKNKDLKLSF---MKKLNLTLSPAKKQPVSQDNQHK 581 T N+ + F MKKL LS K ++ QH+ Sbjct: 2148 QTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTK---IKEEQHE 2189 Score = 45.4 bits (106), Expect = 5e-04 Identities = 108/591 (18%), Positives = 230/591 (38%), Gaps = 81/591 (13%) Query: 65 EGTAKEATYNDLQVEYGKCQLQM------KELMKKFKEI----QTQNFSLINENQSLKKN 114 E TA+ DL+ + K Q ++ +EL+ KE+ +T N + QS K+ Sbjct: 1260 EKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKD 1319 Query: 115 ISALIKTARVEINRK--DEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLD 172 + L AR+E+ R +E+ + + R+N KT + VK LK H+ Sbjct: 1320 STTL---ARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKE---HIR 1373 Query: 173 DC------SKTDHRAKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGV 226 + S++ ++ + + +T + + ++ KP + ++ L +E + Sbjct: 1374 ETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKP----KDSALLRIEIEMLGLSKR 1429 Query: 227 WSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRGTERVRK---------------------- 264 SH ++ + +D + +++ S+ ++ E +++ Sbjct: 1430 LQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQ 1489 Query: 265 -----DLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERIN 319 +L + E I ++L+ +K + K +F S+ + E++N Sbjct: 1490 EETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQ-EKVN 1548 Query: 320 SSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQ 379 + + + S + S K LE + ++ ++ ++KEE K Q+ + +DQ Sbjct: 1549 ELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQ 1608 Query: 380 --DHWRRSERASLPHSKNEITFSHNSSKYHLEERR-GWEDCKRDKSVNSHSFQDGRCPSS 436 ++ + + E F ++ +E+ E K + ++ + Sbjct: 1609 LKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENI 1668 Query: 437 LSNSRTHKNID-----SKEVDAMHQWENTPLKAERHRTEDKRK----REQESKEENRHIR 487 H+N++ +KE D + E T LK ER + ++ + R+ E +EE + + Sbjct: 1669 RLTQILHENLEEMRSVTKERDDLRSVEET-LKVERDQLKENLRETITRDLEKQEELKIVH 1727 Query: 488 NEKRVPTEHLQKTN---KETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAMKAES 544 + E + K E ++++K E D + D + E + +K + Sbjct: 1728 MHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQ 1787 Query: 545 GPNE-----TKNKDLKLSFMKKLNLTLSPAKKQPVSQD---NQHKITDIPK 587 + K KLS M+K +L S AK Q Q+ N+H++ + K Sbjct: 1788 ETIDKLRGIVSEKTDKLSNMQK-DLENSNAKLQEKIQELKANEHQLITLKK 1837 >gi|154146223 splicing factor, arginine/serine-rich 130 [Homo sapiens] Length = 805 Score = 56.2 bits (134), Expect = 3e-07 Identities = 79/381 (20%), Positives = 149/381 (39%), Gaps = 33/381 (8%) Query: 128 RKDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHRAKSDVSK 187 RK++E LH + E + + + + K+ S S L + + D ++ + Sbjct: 428 RKEKEQQLLHDKQME-EEKQQTERVTKEMNEFIHKEQNSLS--LLEAREADGDVVNEKKR 484 Query: 188 DVHHSTSL-------PNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSN 240 + +TS+ EK+G+ S S+ ++ T+ S S Y GSS Sbjct: 485 TPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSR 544 Query: 241 EDSRRG--RKDIRHSQFNRGTERVRKDLSTGCGDG----------EPRILEASQRLQGHP 288 SR ++ RHS+ T + R+ S + R S R Sbjct: 545 TSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIER 604 Query: 289 EKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDK----KLE 344 E+ P E + S+ +S + R S ++ +R + +S K + E Sbjct: 605 ERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQE 664 Query: 345 RQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSK--NEITFSHN 402 R+ ERS++I++ K + ER+ D++ + +++ ++ S + K +E TFS + Sbjct: 665 RKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRS 724 Query: 403 SS-KYHLEERRGWEDCKRD--KSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWEN 459 S + +D K+ K HS D SS + + K + K H Sbjct: 725 GSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSK--EKKAKKPKHSRSR 782 Query: 460 TPLKAERHRTEDKRKREQESK 480 + K++R + RK + +S+ Sbjct: 783 SVEKSQRSGKKASRKHKSKSR 803 Score = 50.8 bits (120), Expect = 1e-05 Identities = 67/311 (21%), Positives = 120/311 (38%), Gaps = 46/311 (14%) Query: 287 HPEKYGKGEPKTESKSS-KFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLER 345 H EK +G ++ S SS SNS + ++SS + G S S +K Sbjct: 499 HKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRH 558 Query: 346 QSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSK 405 RS I + +S+ R + ++ VK +D RRS R S+ + ++ Sbjct: 559 SRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDR-RRSNRNSIERERRR-------NR 610 Query: 406 YHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAE 465 ERR RD+ N +S S SR + ID + + L Sbjct: 611 SPSRERRRSRSRSRDRRTNR---------ASRSRSRDRRKIDDQRGN---------LSGN 652 Query: 466 RHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVL 525 H K + E+KE+ R E + +K+ KK + +++ + + +K + Sbjct: 653 SH------KHKGEAKEQER--------KKERSRSIDKDRKKKDKEREREQDKRKEKQKRE 698 Query: 526 DNGVSEGADNKELAMKAESGPNETKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITDI 585 + + + L K ES +++ + + ++ + + +KK +H +D Sbjct: 699 EKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIR--HDSRQDSKKSTTKDSKKHSGSD- 755 Query: 586 PKSSGVCDSES 596 SSG SES Sbjct: 756 --SSGRSSSES 764 Score = 40.4 bits (93), Expect = 0.017 Identities = 48/250 (19%), Positives = 98/250 (39%), Gaps = 33/250 (13%) Query: 291 YGKGEPKTESKSSKFKSNSDSDYKG------ERINSSWEKETPGERSHSRVDSQSDKKLE 344 YG G+ + E +S + +SD+D + ++ + W KE + H DK++E Sbjct: 391 YGSGDSEDE-RSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLH-------DKQME 442 Query: 345 RQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSS 404 + ++++ + ++ + KE+ + ++ D +E+ P NE T Sbjct: 443 EEKQQTERVTKEMNEFIHKEQNSLSLLE---AREADGDVVNEKKRTP---NETTSVLEPK 496 Query: 405 KYHLEERR-----------GWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDA 453 K H E+ + G S S + SS +SRT S + Sbjct: 497 KEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKK 556 Query: 454 MHQWENTP-LKAERHRTED-KRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDL 511 H +P +KA R R+ R+ + ES IR+ +R +++ + + + + Sbjct: 557 RHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRER 616 Query: 512 KKQNEPKTDK 521 ++ D+ Sbjct: 617 RRSRSRSRDR 626 >gi|154146193 splicing factor, arginine/serine-rich 130 [Homo sapiens] Length = 805 Score = 56.2 bits (134), Expect = 3e-07 Identities = 79/381 (20%), Positives = 149/381 (39%), Gaps = 33/381 (8%) Query: 128 RKDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHRAKSDVSK 187 RK++E LH + E + + + + K+ S S L + + D ++ + Sbjct: 428 RKEKEQQLLHDKQME-EEKQQTERVTKEMNEFIHKEQNSLS--LLEAREADGDVVNEKKR 484 Query: 188 DVHHSTSL-------PNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSN 240 + +TS+ EK+G+ S S+ ++ T+ S S Y GSS Sbjct: 485 TPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSR 544 Query: 241 EDSRRG--RKDIRHSQFNRGTERVRKDLSTGCGDG----------EPRILEASQRLQGHP 288 SR ++ RHS+ T + R+ S + R S R Sbjct: 545 TSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIER 604 Query: 289 EKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDK----KLE 344 E+ P E + S+ +S + R S ++ +R + +S K + E Sbjct: 605 ERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQE 664 Query: 345 RQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSK--NEITFSHN 402 R+ ERS++I++ K + ER+ D++ + +++ ++ S + K +E TFS + Sbjct: 665 RKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRKRESERTFSRS 724 Query: 403 SS-KYHLEERRGWEDCKRD--KSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWEN 459 S + +D K+ K HS D SS + + K + K H Sbjct: 725 GSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSK--EKKAKKPKHSRSR 782 Query: 460 TPLKAERHRTEDKRKREQESK 480 + K++R + RK + +S+ Sbjct: 783 SVEKSQRSGKKASRKHKSKSR 803 Score = 50.8 bits (120), Expect = 1e-05 Identities = 67/311 (21%), Positives = 120/311 (38%), Gaps = 46/311 (14%) Query: 287 HPEKYGKGEPKTESKSS-KFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLER 345 H EK +G ++ S SS SNS + ++SS + G S S +K Sbjct: 499 HKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRH 558 Query: 346 QSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSK 405 RS I + +S+ R + ++ VK +D RRS R S+ + ++ Sbjct: 559 SRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDR-RRSNRNSIERERRR-------NR 610 Query: 406 YHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAE 465 ERR RD+ N +S S SR + ID + + L Sbjct: 611 SPSRERRRSRSRSRDRRTNR---------ASRSRSRDRRKIDDQRGN---------LSGN 652 Query: 466 RHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVL 525 H K + E+KE+ R E + +K+ KK + +++ + + +K + Sbjct: 653 SH------KHKGEAKEQER--------KKERSRSIDKDRKKKDKEREREQDKRKEKQKRE 698 Query: 526 DNGVSEGADNKELAMKAESGPNETKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITDI 585 + + + L K ES +++ + + ++ + + +KK +H +D Sbjct: 699 EKDFKFSSQDDRLKRKRESERTFSRSGSISVKIIR--HDSRQDSKKSTTKDSKKHSGSD- 755 Query: 586 PKSSGVCDSES 596 SSG SES Sbjct: 756 --SSGRSSSES 764 Score = 40.4 bits (93), Expect = 0.017 Identities = 48/250 (19%), Positives = 98/250 (39%), Gaps = 33/250 (13%) Query: 291 YGKGEPKTESKSSKFKSNSDSDYKG------ERINSSWEKETPGERSHSRVDSQSDKKLE 344 YG G+ + E +S + +SD+D + ++ + W KE + H DK++E Sbjct: 391 YGSGDSEDE-RSDRGSESSDTDDEELRHRIRQKQEAFWRKEKEQQLLH-------DKQME 442 Query: 345 RQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSS 404 + ++++ + ++ + KE+ + ++ D +E+ P NE T Sbjct: 443 EEKQQTERVTKEMNEFIHKEQNSLSLLE---AREADGDVVNEKKRTP---NETTSVLEPK 496 Query: 405 KYHLEERR-----------GWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDA 453 K H E+ + G S S + SS +SRT S + Sbjct: 497 KEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKK 556 Query: 454 MHQWENTP-LKAERHRTED-KRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDL 511 H +P +KA R R+ R+ + ES IR+ +R +++ + + + + Sbjct: 557 RHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNSIERERRRNRSPSRER 616 Query: 512 KKQNEPKTDK 521 ++ D+ Sbjct: 617 RRSRSRSRDR 626 >gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens] Length = 1564 Score = 55.5 bits (132), Expect = 5e-07 Identities = 114/554 (20%), Positives = 216/554 (38%), Gaps = 66/554 (11%) Query: 69 KEATYNDLQVEYGKCQLQMKELMKKFKEIQTQNFSLINENQSLKKNISALIKTARVEINR 128 KE TY + YG+ L ++ + +N S NE++S +N RV Sbjct: 518 KEDTYPEESRSYGR-----NHLREESSRTEIRNESR-NESRSEIRNDRMGRSRGRVP--- 568 Query: 129 KDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHRAKS-DVSK 187 E+ R S ++ + D+ +T+ S P D + D+R ++ D S Sbjct: 569 ---ELPEKGSRGSRGSQIDSHSSNSNYHDSWETR---SSYPERDRYPERDNRDQARDSSF 622 Query: 188 DVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRRGR 247 + H + D R P+S +H + ++ E+ R R Sbjct: 623 ERRHGE---------RDRRDNRERDQRPSSPIRH------QGRNDELERDERREERRVDR 667 Query: 248 KDIRHSQFNRGTERVR-KDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFK 306 D R + R +R R +D R E + + E+ + E + E + + + Sbjct: 668 VDDRRDERARERDRERERDRERERERERERDREREKERELERERAREREREREKERDR-E 726 Query: 307 SNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKSQDKE-E 365 + D D+ ER E++ ER R + + +++ ER+ ER + R+ + +DKE E Sbjct: 727 RDRDRDHDRERERER-ERDREKEREREREERERERERERERERERERERERARERDKERE 785 Query: 366 RKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLE---ERRGWEDCKRDKS 422 R+ D + K +D +R E + ++ + +Y E R +R+ S Sbjct: 786 RQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHS 845 Query: 423 VNSHSFQDG-------RCPSSLSNSRTHKNIDSKEV--DAMHQWENTPLKAERHRTEDKR 473 +S ++ G R S + + +++ + D +W+ K ER + +R Sbjct: 846 PDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPER-KESSRR 904 Query: 474 KREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGA 533 EQE KE+ + +++R TE L+ + + + ++ +D+ +N Sbjct: 905 YEEQELKEKVSSV-DKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHD-ENKKKAKI 962 Query: 534 DNKELAMKAES------GPNETKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITDIPK 587 K + K E G ET ++D ++ KK S KK+ S+ + Sbjct: 963 QKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGD--------- 1013 Query: 588 SSGVCDSESSMQVK 601 S + D E++ Q K Sbjct: 1014 -SDISDEEAAQQSK 1026 Score = 51.6 bits (122), Expect = 8e-06 Identities = 102/504 (20%), Positives = 188/504 (37%), Gaps = 84/504 (16%) Query: 59 EEILTEEGTAKEATYNDLQVEY-GKCQLQMKELMKKFKEIQTQNFSLINENQSLKKNISA 117 EE + E ++ D+ +Y + L+MK ++IQ + L EN ++ I Sbjct: 139 EENVEWETNRDDSDNGDINYDYVHELSLEMKR-----QKIQRELMKLEQENMEKREEI-- 191 Query: 118 LIKTARVEINRKDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKT 177 I +K+ + +LS P R + K+ + + SP SK Sbjct: 192 --------IIKKEVSPEVVRSKLSPSPSLRKSSKSPK----------RKSSPKSSSASKK 233 Query: 178 DHRAKSDVSKDVHHSTSLPNLEKEGKPHSDKRS---TSHLPTSVEKHCTNGVWSRSHYQV 234 D + + S+ L + ++ K + K+ T P + + G + Y+V Sbjct: 234 DRKTSAV-------SSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKV 286 Query: 235 GEGSSNEDSRRGRKDIRHSQFNRGTERVRKDLSTG-CGDGEPRIL--------EASQRLQ 285 + E+ R KD R F R E+ K ST G I ++ +Q Sbjct: 287 KDRI--EEKTRDGKD-RGRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQ 343 Query: 286 GH---PEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETP----------GERSH 332 H P + P + + S S Y ++S K++P G H Sbjct: 344 RHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDH 403 Query: 333 SRVDSQSDKKLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPH 392 R D++ ER R +++ + +EER+ +Q S +DH R +R Sbjct: 404 ERTSQSHDRRHER---REDTRGKRDREKDSREEREYEQDQSS---SRDH--RDDREP-RD 454 Query: 393 SKNEITFSHNSSKYHLEERRGWEDCK--RDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKE 450 ++ + L + R D + RD S ++ +D R S ++ +++ + ++ Sbjct: 455 GRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRD 514 Query: 451 V--------DAMHQWENTPLKAERHRTEDKRKREQESKEE---NRHIRNEKRVPTEHLQK 499 + + L+ E RTE + + ES+ E +R R+ RVP E +K Sbjct: 515 THRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVP-ELPEK 573 Query: 500 TNKETKKTTTDLKKQNEPKTDKGE 523 ++ ++ + D N D E Sbjct: 574 GSRGSRGSQIDSHSSNSNYHDSWE 597 Score = 43.1 bits (100), Expect = 0.003 Identities = 71/323 (21%), Positives = 120/323 (37%), Gaps = 46/323 (14%) Query: 186 SKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGS----SNE 241 ++D H +EK PH H +K ++ +RS+ G SN+ Sbjct: 1153 NEDSHRKCHRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSND 1212 Query: 242 DSRR------GRKDIRHSQFNRGTERVRKDLSTG--------CGDGEPRILEASQRLQGH 287 + R GRK + HS +R E+ + TG GEP +S R Sbjct: 1213 SAHRSGDDQSGRKRVLHSG-SRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSR 1271 Query: 288 PEKYGKGEPKTESKSSKFKSNSDS-DYKGERINSSWEKETPGERSHSRV---DSQSDKKL 343 + P+++ + + DS D ER ++E ER +R D +DK Sbjct: 1272 SHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDW 1331 Query: 344 ERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQ-DHWRRSERASLPHSKNEITFSHN 402 R +R + R+ + +DK R +D++ + ++ D + R +R S + Sbjct: 1332 PRNRDRDRLRERERERERDK-RRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRC 1390 Query: 403 SSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPL 462 +K E R E RD +L R K++ S + +E T Sbjct: 1391 EAKLEGEHERDLESTSRDS-------------LALDKERMDKDLGS-----VQGFEET-- 1430 Query: 463 KAERHRTEDKRKREQESKEENRH 485 + RTE + ESK ++ H Sbjct: 1431 -NKSERTESLEAGDDESKLDDAH 1452 Score = 32.3 bits (72), Expect = 4.7 Identities = 44/210 (20%), Positives = 79/210 (37%), Gaps = 18/210 (8%) Query: 200 KEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRGT 259 K G+P RSTS H + S QV S + DSR ++ + +R Sbjct: 1255 KRGEP---SRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRER 1311 Query: 260 ERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGER-I 318 ER R+D D + + P + + + + D D + ER I Sbjct: 1312 ERERRDTRQREWDRDAD--------KDWPRNRDRDRLRERERERERDKRRDLDRERERLI 1363 Query: 319 NSSWEKETPGERSHSRVDSQSDK------KLERQSERSQNINRKEVKSQDKEERKVDQKP 372 + S E++ +R + SQ + KLE + ER ++ + DKE D Sbjct: 1364 SDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEHERDLESTSRDSLALDKERMDKDLGS 1423 Query: 373 KSVVKDQDHWRRSERASLPHSKNEITFSHN 402 ++ + R+E ++++ +H+ Sbjct: 1424 VQGFEETNKSERTESLEAGDDESKLDDAHS 1453 >gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sapiens] Length = 750 Score = 55.1 bits (131), Expect = 7e-07 Identities = 109/587 (18%), Positives = 230/587 (39%), Gaps = 84/587 (14%) Query: 58 YEEILTEEGTAKEATYNDLQVEYGKCQLQMKELMKKFKEIQTQNFSLINENQS------- 110 ++E L E A+ T L + + Q+ + K+++ + LI+ Sbjct: 117 HQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGE 176 Query: 111 LKKNISALIKTARVEINRKDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPH 170 L++ +SA + T + + +R EE++ LS +RN T+ ++LK ++ Sbjct: 177 LEQALSA-VATQKKKADRYIEELTKERDALS-LELYRN---------TITDEELKEKNAK 225 Query: 171 LDDCSKTDHRAKSDVSKDVHH--------STSLPNLEKEGKP-HSDKRSTS---HLPTSV 218 L + + KS++ +V LP + + + H K S L V Sbjct: 226 LQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQV 285 Query: 219 EKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRIL 278 E+ N +W+R + Q ++ + R++ + ++ E++++ E +I Sbjct: 286 EE---NELWNRLNQQ-------QEEKMWRQEEKIQEWE---EKIQEQ--------EEKIR 324 Query: 279 EASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGE-----RINSSWEKETPGERSHS 333 E ++++ EK + E K K + + ++ E + WEKE R Sbjct: 325 EQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEE 384 Query: 334 RVDSQSDK--KLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLP 391 + + +K +LE + + I +E K Q EE K+ ++ K ++ WR+ E+ Sbjct: 385 MMWEKEEKIRELEEKMHEQEKIREQEEKRQ--EEEKIREQEKRQEQEAKMWRQEEKIREQ 442 Query: 392 HSK---NEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDS 448 K E K H +E+ E+ ++++ Q+ + R + + Sbjct: 443 EEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWR--QEEKIHEQEEIWRQKEKMHE 500 Query: 449 KEVDAMHQWENTPLKAERHRTEDKRKREQESK----------------EENRHIRNEKRV 492 +E Q E + E+ R ++++ REQE K EE + EK Sbjct: 501 QEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIW 560 Query: 493 PTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAMKAESGPNETKNK 552 E Q+ + + +++Q E + E + + + +E K E E + K Sbjct: 561 EEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEK 620 Query: 553 DLKLSFMKKLNLTLSPAKKQPVSQDNQHKITDIPKSSGVCDSESSMQ 599 ++ K +++ ++Q+ + K+ + + +C+ E MQ Sbjct: 621 -IQEQEEKIREQEEKIREQEEMTQEQEEKMGE--QEEKMCEQEEKMQ 664 Score = 39.7 bits (91), Expect = 0.030 Identities = 28/148 (18%), Positives = 59/148 (39%), Gaps = 8/148 (5%) Query: 274 EPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHS 333 E + E ++ EK + E K + K + + + E+ W++E Sbjct: 562 EEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEK--RQEQEEKMWKQEEKIREQEE 619 Query: 334 RVDSQSDKKLERQS---ERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASL 390 ++ Q +K E++ E+ + +E K ++EE+ +Q+ K +++ WR+ E+ Sbjct: 620 KIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIRE 679 Query: 391 PHSK---NEITFSHNSSKYHLEERRGWE 415 K E +E + WE Sbjct: 680 QEKKIREQEEKIREQEEMMQEQEEKMWE 707 Score = 38.5 bits (88), Expect = 0.066 Identities = 31/152 (20%), Positives = 62/152 (40%), Gaps = 16/152 (10%) Query: 274 EPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHS 333 E +I E ++ Q EK K E K + K + + + E E+E + Sbjct: 590 EEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEE--KIREQEEMTQEQEE 647 Query: 334 RVDSQSDK------KLERQSE----RSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWR 383 ++ Q +K K++ Q E + + I +E K +++EE+ +Q+ +++ W Sbjct: 648 KMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWE 707 Query: 384 RSERASLPHSKNEITFSHNSSKYHLEERRGWE 415 + E+ + E K +E + WE Sbjct: 708 QEEKM----CEQEEKMQEQEEKMRRQEEKMWE 735 Score = 36.2 bits (82), Expect = 0.33 Identities = 24/122 (19%), Positives = 54/122 (44%), Gaps = 8/122 (6%) Query: 274 EPRILEASQRLQGHPEKYGKGEPKTESKSSKF-----KSNSDSDYKGERINSSWEKETPG 328 E +I E ++++ EK + E T+ + K K + E+ + W +E Sbjct: 618 EEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKI 677 Query: 329 ERSHSRVDSQSDKKLERQS---ERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRS 385 ++ Q +K E++ E+ + + +E K ++EE+ +Q+ K +++ W + Sbjct: 678 REQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQE 737 Query: 386 ER 387 R Sbjct: 738 VR 739 Score = 32.7 bits (73), Expect = 3.6 Identities = 23/117 (19%), Positives = 48/117 (41%), Gaps = 6/117 (5%) Query: 257 RGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGE 316 R E + ++ G+ E ++ E +++Q E + E K + K + E Sbjct: 636 REQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQE------E 689 Query: 317 RINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKSQDKEERKVDQKPK 373 +I E E + + ++ E+ E+ + + R+E K ++E R Q+ K Sbjct: 690 KIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEK 746 >gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like protein 6 [Homo sapiens] Length = 724 Score = 55.1 bits (131), Expect = 7e-07 Identities = 67/341 (19%), Positives = 136/341 (39%), Gaps = 36/341 (10%) Query: 274 EPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGE-----RINSSWEKETPG 328 E +I E +++Q EK + E K + K + + ++ E + WEKE Sbjct: 367 EEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKM 426 Query: 329 ERSHSRVDSQSDK--KLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSE 386 R + + +K +LE + + I +E K Q EE K+ ++ K ++ WR+ E Sbjct: 427 RRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQ--EEEKIREQEKRQEQEAKMWRQEE 484 Query: 387 RASLPHSK---NEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTH 443 + K E K H +E+ E+ ++++ Q+ + R Sbjct: 485 KIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWR--QEEKIREQEEIWRQK 542 Query: 444 KNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESK----EENRHIRNEK-RVPTEHLQ 498 + I +E Q E + E+ ++++ REQE K EE + EK R E ++ Sbjct: 543 EKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIR 602 Query: 499 KTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAMKAESGPNETKNKDLKLSF 558 + + T++ + +Q E ++ E + + +E + E E + K Sbjct: 603 EQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEK------ 656 Query: 559 MKKLNLTLSPAKKQPVSQDNQHKITDIPKSSGVCDSESSMQ 599 +++ + Q+ + K+ + + +C+ E MQ Sbjct: 657 ---------IREQEEMMQEQEEKMWE--QEEKMCEQEEKMQ 686 Score = 48.5 bits (114), Expect = 6e-05 Identities = 47/247 (19%), Positives = 105/247 (42%), Gaps = 31/247 (12%) Query: 276 RILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRV 335 ++L Q+LQ + GK + +S S+K ++ + N W +R+ Sbjct: 316 KLLLPQQQLQAEADHLGK---ELQSVSAKLQAQVEE-------NELW----------NRL 355 Query: 336 DSQSDKKLERQSERSQN----INRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLP 391 + Q ++K+ RQ E+ Q I +E K +++EE+ +Q+ K +++ W + E+ Sbjct: 356 NQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKM--- 412 Query: 392 HSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEV 451 + E K +E WE ++ + + + + + + I +E Sbjct: 413 -RRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQE- 470 Query: 452 DAMHQWENTPLKAERHRTEDKRKREQESK--EENRHIRNEKRVPTEHLQKTNKETKKTTT 509 Q + E+ R ++++ REQE K + I ++++ E ++ +E + Sbjct: 471 KRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEE 530 Query: 510 DLKKQNE 516 +++Q E Sbjct: 531 KIREQEE 537 Score = 36.6 bits (83), Expect = 0.25 Identities = 32/149 (21%), Positives = 60/149 (40%), Gaps = 11/149 (7%) Query: 241 EDSRRGRKDIRHSQFN-RGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTE 299 E R + IR + R E + ++ G+ E ++ E +++Q EK + E K Sbjct: 585 EKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIR 644 Query: 300 SKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVK 359 + K + E+I E E + + ++ E+ E+ + + R+E K Sbjct: 645 EQEKKIREQE------EKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEK 698 Query: 360 SQDKEERKVDQKPKSVVKDQDHWRRSERA 388 ++E R Q+ K Q+H E A Sbjct: 699 MWEQEVRLRQQEEKM----QEHQEHLEAA 723 >gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] Length = 2454 Score = 55.1 bits (131), Expect = 7e-07 Identities = 80/376 (21%), Positives = 149/376 (39%), Gaps = 35/376 (9%) Query: 161 TKDLKSRSPHLDDCSKTDHRAKSDVSKDVHHSTSLPN---LEKEGKPHSDKRSTSHLPTS 217 TK+++S S S +D S+ +K TS + KE K +S + ST Sbjct: 1108 TKEIQSGS------SSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQAD 1161 Query: 218 VEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKD----IRHSQF--NRGTERVRKDLSTGCG 271 + ++ + +GEGSS+E + + H+ F + G E + K + Sbjct: 1162 ITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVD 1221 Query: 272 DGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPG-ER 330 D + + R+ +K E K S + S+ D +G++ +E PG E Sbjct: 1222 DDDDDN-DPENRIA---KKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEE 1277 Query: 331 SHSRVDSQSDKKLERQSE---RSQNINRKEVKSQDK--EERKVDQKPKSVVKDQDHWRRS 385 + ++V+S+SD E + R + + K S + EE+K K VK ++ + S Sbjct: 1278 AKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVS 1337 Query: 386 ERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKN 445 S E S S+ E+R R +S ++ + S + + Sbjct: 1338 SEDSEDSDFQESGVSEEVSESEDEQR------PRTRSAKKAELEENQ--RSYKQKKKRRR 1389 Query: 446 IDSKEVDAMHQWENTPLKAERHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNKETK 505 I +E + N+ + E E++ + E+E +EE ++ + P + +K K K Sbjct: 1390 IKVQEDSSSENKSNS--EEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILK 1447 Query: 506 KTTTDLKKQNEPKTDK 521 + QN K ++ Sbjct: 1448 DDKLRTETQNALKEEE 1463 Score = 47.0 bits (110), Expect = 2e-04 Identities = 122/635 (19%), Positives = 234/635 (36%), Gaps = 129/635 (20%) Query: 95 KEIQTQNFSLINENQSLKKNISALIKTARVEINRKDEEISNLHQRLSEFPHFRNNHKTAR 154 K+ QTQ+ S N + L+K I ++ K +K I N +F + + + Sbjct: 768 KKRQTQSESS-NYDSELEKEIKSMSKIGAARTTKK--RIPNT----KDFDSSEDEKHSKK 820 Query: 155 TFDTVKTKDLK-SRSPHLDDCSKTDHR-----AKSDVSKDV-------------HHSTSL 195 D K+LK S+ DD + R A+ V KD S S Sbjct: 821 GMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASAST 880 Query: 196 PNLEK-EGKPHS-----------DKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSNEDS 243 ++K GK S K + HL T K +G+ + + + S+E S Sbjct: 881 DGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETS 940 Query: 244 RRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTESKSS 303 +K Q +GTE +K D + ++++ Q+ + + + Sbjct: 941 EDDKK-----QSKKGTEEKKKP-----SDFKKKVIKMEQQYES-----------SSDGTE 979 Query: 304 KFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKSQDK 363 K + + + I T GE+ ++ ++ KK + S+ ++ K Sbjct: 980 KLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSS 1039 Query: 364 EERKVDQKPKSVVKDQDHWRRSERASL---PHSKNEITFSHNSSKYHLEERRGWEDCKR- 419 E++K K+ + R +R L K + S ++ KY ++E + C Sbjct: 1040 EDKKS--------KNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKE----DGCNSS 1087 Query: 420 DKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQES 479 DK + ++ R +LS+ R K I S + AE ++K+K+++ S Sbjct: 1088 DKRLKRIELRERR---NLSSKRNTKEIQSGSSSS---------DAEESSEDNKKKKQRTS 1135 Query: 480 KEENRHIRNEKR---VPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNK 536 ++ I EK+ + T +K T +++D++ ++ +G + + +N Sbjct: 1136 SKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENL 1195 Query: 537 ELA---------------------MKAESGPNETKNKDLKLSFMKKLNLTLS-------- 567 L+ + + N+ +N+ K ++++ LS Sbjct: 1196 VLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSD 1255 Query: 568 ----PAKKQPVSQDNQHKITDIPKSSGVCDSES-SMQVKTVAYVPSISEHILGEAAVSEH 622 KK+ Q+ ++ + K+ +S+S S + K Y + H L VS+ Sbjct: 1256 DEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKL---TVSDG 1312 Query: 623 TMGETKSTLLEPKVALLAVTEPRIGISETNKEDEN 657 GE K T +PK R +S + ED + Sbjct: 1313 ESGEEKKT--KPKEHKEVKGRNRRKVSSEDSEDSD 1345 Score = 39.3 bits (90), Expect = 0.039 Identities = 67/328 (20%), Positives = 128/328 (39%), Gaps = 60/328 (18%) Query: 300 SKSSKFKSNSDSDY-----KGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNIN 354 ++++ SNSD + + ++++ K+ S S +D+ KL + S++S+ ++ Sbjct: 630 TETNPVTSNSDEECNETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPK-SKQSETVD 688 Query: 355 RKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGW 414 + + D +E K S R S +S NEI +H + Y L+ + G Sbjct: 689 Q----NSDSDEMLAILKEVS--------RMSHSSSSDTDINEIHTNHKTL-YDLKTQAGK 735 Query: 415 EDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRK 474 +D + K +S S D D+K+ K+ + K+K Sbjct: 736 DDKGKRKRKSSTSGSD---------------FDTKKG-----------KSAKSSIISKKK 769 Query: 475 REQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGAD 534 R+ +S+ N EK + + + TKK + K + + +K +G D Sbjct: 770 RQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHS------KKGMD 823 Query: 535 N---KELAMKAESGPNETKNKDLKLSF------MKKLNLTLSPAKKQPVSQDNQHKITDI 585 N K L E ++ + K + +F + K + + P Q + Sbjct: 824 NQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGV 883 Query: 586 PKSSGVCDSESSMQVKTVAYVPSISEHI 613 K SG S +S++V+ VA S+H+ Sbjct: 884 DKLSGKEQSFTSLEVRKVAETKEKSKHL 911 Score = 37.7 bits (86), Expect = 0.11 Identities = 93/445 (20%), Positives = 164/445 (36%), Gaps = 93/445 (20%) Query: 265 DLSTGCGDG----EPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINS 320 DL T C E + + ++++ EK K T S K K++S+ + + ++++ Sbjct: 237 DLVTACNSVFENLEQLLQQNKKKIKVDSEKSNKVYEHTSRFSPK-KTSSNCNGEEKKLDD 295 Query: 321 SWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVK--------SQDKEERKVDQKP 372 S S V + KK ++ E + N+N VK S+ K+ Q Sbjct: 296 SCSGSVTYSYSALIVPKEMIKKAKKLIETTANMNSSYVKFLKQATDNSEISSATKLRQLK 355 Query: 373 --KSVVKD--------QDHWRRSERASLPHSKNEITFSHN--SSKYHLEERRGWEDCKRD 420 KSV+ D ++ RA +K + T H +K+ + R+G + C + Sbjct: 356 AFKSVLADIKKAHLALEEDLNSEFRAMDAVNKEKNTKEHKVIDAKFETKARKGEKPCALE 415 Query: 421 KSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESK 480 K S++ + K+VD+ H +N P TE++R + Sbjct: 416 KK---------------DISKSEAKLSRKQVDSEHMHQNVP-------TEEQRTNKSTGG 453 Query: 481 EENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAM 540 E + R E + E T+ DL D V + + +N E AM Sbjct: 454 EHKKSDRKE---------EPQYEPANTSEDL------DMDIVSVPSSVPEDIFENLETAM 498 Query: 541 KAESG-----------PNETKNKDLKLSFMKKLNL-TLSPAKKQPVSQDNQHKITDIPKS 588 + +S E ++ +KL+ K N + V+++ K+T + S Sbjct: 499 EVQSSVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTTAKVTKELYVKLTPVSLS 558 Query: 589 SGVCDSESSMQV-------KTVAYVPSISEHILG-EAAVSEHTMGETKSTLLE------- 633 + +V K+ P + + LG E + +EH + S LLE Sbjct: 559 NSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVENEVSLLLEESDLRRS 618 Query: 634 PKVALLAVTEPRIGISETNKEDENS 658 P+V + P +ETN NS Sbjct: 619 PRVKTTPLRRP----TETNPVTSNS 639 Score = 35.0 bits (79), Expect = 0.73 Identities = 101/522 (19%), Positives = 177/522 (33%), Gaps = 86/522 (16%) Query: 885 SHKDVFLPNSAHSTSKSQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSET 944 S K + T S+ + E +K I K A T K R + Sbjct: 759 SAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKK-----------RIPNTK 807 Query: 945 SKPQESFEKNSKRRVSADVRKSKTIPRRGKSTVCLDKDSRKTHVRIHQTNNK-------W 997 EK+SK+ + K+ + G S K R+T T +K Sbjct: 808 DFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELR 867 Query: 998 NKRPDKSSRSSKTEKKDKVMSTSSLEKIVPIIAVPSSEQEIMHMLRMIRKHVRKNYMKFK 1057 ++ P K S+ T+ DK+ + + V ++++ H+ K V+ Sbjct: 868 DRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIA 927 Query: 1058 AKF------------SLIQFHRIIESAILSFTSLIKHLNLHKISKSVTTLQKNLCDIIE- 1104 KF Q + E K + + + +S + + L + E Sbjct: 928 EKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEI 987 Query: 1105 ----SKLKQVKKNGIVDRLFEQQLPDMKKKLWKFVDDQLDYLFAKLKKILVCDSKSFGR- 1159 +KQ+K NG D E++ ++ K K D+ DY KS G+ Sbjct: 988 CHFPKGIKQIK-NGTTDG--EKKSKKIRDKTSKKKDELSDYA-----------EKSTGKG 1033 Query: 1160 DSDEGKLEKTSKQNAQYSNSQKRSVDNSNRELLKEKLSKSEDPVHYKSLVGCKKSEE--- 1216 DS + +K SK N Y +KR ++ S S+ + GC S++ Sbjct: 1034 DSCDSSEDKKSK-NGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLK 1092 Query: 1217 --NYQDQNNSSINTVKHDIKKNFNICFDNIKNSQSEERSLEVHCPSTPKSEKNEGSSIED 1274 +++ N S K+N +S +EE S + S K + +++ Sbjct: 1093 RIELRERRNLS-------SKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKE 1145 Query: 1275 AQTSQHATLKPERSFEILT--------------------EQQASSLTFNLVSDAQMGEIF 1314 + + T + +I + EQ+ +T NLV + G Sbjct: 1146 KKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQ 1205 Query: 1315 KSLLQGSDLLDSSVNCTEKSEWELKTPEKQLLETLKCESIPA 1356 S G + L SV T + + PE ++ + + E I A Sbjct: 1206 SS---GDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKA 1244 Score = 34.7 bits (78), Expect = 0.95 Identities = 92/513 (17%), Positives = 185/513 (36%), Gaps = 45/513 (8%) Query: 82 KCQLQMKELMKKF-KEIQTQNFSLINENQSLK----KNISALIKTARVEINRKDEEISNL 136 K Q + ++ +KF K+ Q+ S ++ QS K K + K +++ ++ E S+ Sbjct: 918 KVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDG 977 Query: 137 HQRLSE------FPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHRAKSDVSKDVH 190 ++L E FP K T K+K ++ ++ D +D+ KS D Sbjct: 978 TEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKD-ELSDYAEKSTGKGDSC 1036 Query: 191 HSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDI 250 S+ K G +K+ L S K Y + E N +R ++ Sbjct: 1037 DSSE-DKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIE 1095 Query: 251 RHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKS-NS 309 + N ++R K++ +G + E+S+ + ++ + K K S + Sbjct: 1096 LRERRNLSSKRNTKEIQSGSSSSDAE--ESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRT 1153 Query: 310 DSDYKGERINSSWEKETPGERSHSRVDSQSDK-KLERQSERSQNINRKEVKSQDKEERKV 368 + K I SS + + +S + SD+ K++ +E + +E Sbjct: 1154 STKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALS 1213 Query: 369 DQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSF 428 P +V D D R + EI + +S + + E KR N + Sbjct: 1214 KSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENP 1273 Query: 429 QDGRCPSSLSNSRTHKNIDSKEVDAMHQW-------------ENTPLKAERHRTEDKRKR 475 D + +++ + +SK+ H+ E K + H+ R R Sbjct: 1274 GDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNR 1333 Query: 476 EQESKEENR--------------HIRNEKRVPTEHLQKTN-KETKKTTTDLKKQNEPKTD 520 + S E++ +E+R T +K +E +++ KK+ K Sbjct: 1334 RKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQ 1393 Query: 521 KGEVLDNGVSEGADNKELAMKAESGPNETKNKD 553 + +N + + +E + E E + ++ Sbjct: 1394 EDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEE 1426 Score = 33.1 bits (74), Expect = 2.8 Identities = 88/449 (19%), Positives = 163/449 (36%), Gaps = 97/449 (21%) Query: 898 TSKSQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKNSKR 957 TSK + +L+ +K K D C ++ K+ + G + + K K+S++ Sbjct: 1015 TSKKKDELSDYAEKSTGKGDSCDSSEDKKS------KNGAYGREKKRCK---LLGKSSRK 1065 Query: 958 RVSADVRKSKTIPRRGKSTVCLDKDSRKTHVRIHQTNNKWNKRPDKSSRS---------S 1008 R D S T K C D R + + + N +KR K +S S Sbjct: 1066 R--QDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEES 1123 Query: 1009 KTEKKDKVMSTSSLEKIVPIIAVPSSEQEIMHMLRMIRKHVRKNYMKFKAKFSLIQFHRI 1068 + K K TSS +K V I K ++N ++ K R Sbjct: 1124 SEDNKKKKQRTSSKKKAV------------------IVKEKKRNSLRTSTK-------RK 1158 Query: 1069 IESAILSFTSLIKHLNLHKISKSVTTLQKNLCDIIESKLKQVKKNGIVDRL--FEQQLPD 1126 S +S I+ + + I + + E K+K V +N ++ F Q D Sbjct: 1159 QADITSSSSSDIEDDDQNSIGEGSSD---------EQKIKPVTENLVLSSHTGFCQSSGD 1209 Query: 1127 --MKKKLWKFVDDQLD-----------YLFAKLKKILVCDSKSFGRDSDEGKLEKTSKQN 1173 + K + VDD D L ++K L D D E ++T KQN Sbjct: 1210 EALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQN 1269 Query: 1174 AQY---------------SNSQKRSVDNSNRELLKEKLS---------KSEDPVHYKSLV 1209 + S+S++ LL+ KL+ K P +K + Sbjct: 1270 EENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVK 1329 Query: 1210 GCKKSEENYQDQNNSSI--NTVKHDIKKNFNICFDNIKNSQSEERSLEVHCPSTPKSEKN 1267 G + + + +D +S + V ++ ++ + ++++ E LE + S + +K Sbjct: 1330 GRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAE--LEENQRSYKQKKKR 1387 Query: 1268 EGSSIEDAQTSQHATLKPERSFEILTEQQ 1296 +++ +S++ + E E E++ Sbjct: 1388 RRIKVQEDSSSENKSNSEEEEEEKEEEEE 1416 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.308 0.124 0.346 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 76,083,022 Number of Sequences: 37866 Number of extensions: 3615787 Number of successful extensions: 19286 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 102 Number of HSP's successfully gapped in prelim test: 685 Number of HSP's that attempted gapping in prelim test: 14216 Number of HSP's gapped (non-prelim): 4482 length of query: 1982 length of database: 18,247,518 effective HSP length: 117 effective length of query: 1865 effective length of database: 13,817,196 effective search space: 25769070540 effective search space used: 25769070540 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.6 bits) S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.