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Search of human proteins with 21166380
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21166380 neurexin 2 isoform alpha-2 precursor [Homo sapiens]
(1642 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21166380 neurexin 2 isoform alpha-2 precursor [Homo sapiens] 3340 0.0
gi|14211536 neurexin 2 isoform alpha-1 precursor [Homo sapiens] 3294 0.0
gi|14149613 neurexin 1 isoform alpha1 precursor [Homo sapiens] 1900 0.0
gi|208609951 neurexin 1 isoform alpha2 precursor [Homo sapiens] 1861 0.0
gi|21070969 neurexin 3 isoform 1 precursor [Homo sapiens] 1437 0.0
gi|21166382 neurexin 2 isoform beta precursor [Homo sapiens] 1095 0.0
gi|21070967 neurexin 1 isoform beta precursor [Homo sapiens] 382 e-105
gi|41350305 neurexin 3 isoform 2 precursor [Homo sapiens] 347 7e-95
gi|157427673 neurexin 3 isoform 3 precursor [Homo sapiens] 328 2e-89
gi|54873613 agrin [Homo sapiens] 162 2e-39
gi|47519929 cell recognition molecule CASPR3 [Homo sapiens] 139 2e-32
gi|116284404 cell recognition protein CASPR4 isoform 1 [Homo sap... 138 4e-32
gi|7662350 cell recognition molecule Caspr2 precursor [Homo sapi... 136 1e-31
gi|38788416 laminin, alpha 1 precursor [Homo sapiens] 135 2e-31
gi|239743756 PREDICTED: hypothetical protein LOC389722 isoform 2... 135 2e-31
gi|239743754 PREDICTED: hypothetical protein LOC389722 isoform 1... 135 2e-31
gi|4505463 contactin associated protein 1 precursor [Homo sapiens] 133 1e-30
gi|18640734 contactin associated protein-like 5 [Homo sapiens] 119 2e-26
gi|148664242 cell recognition protein CASPR4 isoform 2 [Homo sap... 116 2e-25
gi|33469931 EGF-like, fibronectin type III and laminin G domains... 114 6e-25
gi|33469929 EGF-like, fibronectin type III and laminin G domains... 114 6e-25
gi|239743797 PREDICTED: similar to cell recognition molecule CAS... 112 3e-24
gi|33469935 EGF-like, fibronectin type III and laminin G domains... 110 1e-23
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 100 1e-20
gi|224451128 eyes shut homolog isoform 1 [Homo sapiens] 91 9e-18
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens] 90 2e-17
gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo... 89 3e-17
gi|28559088 laminin alpha 2 subunit isoform a precursor [Homo sa... 89 3e-17
gi|219842266 usherin isoform B [Homo sapiens] 87 2e-16
gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo ... 82 3e-15
>gi|21166380 neurexin 2 isoform alpha-2 precursor [Homo sapiens]
Length = 1642
Score = 3340 bits (8660), Expect = 0.0
Identities = 1642/1642 (100%), Positives = 1642/1642 (100%)
Query: 1 MASGSRWRPTPPPLLLLLLLALAARADGLEFGGGPGQWARYARWAGAASSGELSFSLRTN 60
MASGSRWRPTPPPLLLLLLLALAARADGLEFGGGPGQWARYARWAGAASSGELSFSLRTN
Sbjct: 1 MASGSRWRPTPPPLLLLLLLALAARADGLEFGGGPGQWARYARWAGAASSGELSFSLRTN 60
Query: 61 ATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDRWHMVLLTRD 120
ATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDRWHMVLLTRD
Sbjct: 61 ATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDRWHMVLLTRD 120
Query: 121 ARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLSTVKYEPPFRGLLA 180
ARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLSTVKYEPPFRGLLA
Sbjct: 121 ARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLSTVKYEPPFRGLLA 180
Query: 181 NLKLGERPPALLGSQGLRGATADPLCAPARNPCANGGLCTVLAPGEVGCDCSHTGFGGKF 240
NLKLGERPPALLGSQGLRGATADPLCAPARNPCANGGLCTVLAPGEVGCDCSHTGFGGKF
Sbjct: 181 NLKLGERPPALLGSQGLRGATADPLCAPARNPCANGGLCTVLAPGEVGCDCSHTGFGGKF 240
Query: 241 CSEEEHPMEGPAHLTLNSEGKEEFVATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRN 300
CSEEEHPMEGPAHLTLNSEGKEEFVATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRN
Sbjct: 241 CSEEEHPMEGPAHLTLNSEGKEEFVATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRN 300
Query: 301 GLMLHTGKSADYVNLSLKSGAVWLVINLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQ 360
GLMLHTGKSADYVNLSLKSGAVWLVINLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQ
Sbjct: 301 GLMLHTGKSADYVNLSLKSGAVWLVINLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQ 360
Query: 361 HAGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGCL 420
HAGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGCL
Sbjct: 361 HAGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGCL 420
Query: 421 KDVVYKNNDFKLELSRLAKEGDPKMKLQGDLSFRCEDVAALDPVTFESPEAFVALPRWSA 480
KDVVYKNNDFKLELSRLAKEGDPKMKLQGDLSFRCEDVAALDPVTFESPEAFVALPRWSA
Sbjct: 421 KDVVYKNNDFKLELSRLAKEGDPKMKLQGDLSFRCEDVAALDPVTFESPEAFVALPRWSA 480
Query: 481 KRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGS 540
KRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGS
Sbjct: 481 KRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGS 540
Query: 541 GGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNSRSTPFLATGDSEILDLESELYLGGL 600
GGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNSRSTPFLATGDSEILDLESELYLGGL
Sbjct: 541 GGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNSRSTPFLATGDSEILDLESELYLGGL 600
Query: 601 PEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETL 660
PEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETL
Sbjct: 601 PEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETL 660
Query: 661 KQCASAPCRNGGVCREGWNRFICDCIGTGFLGRVCEREATVLSYDGSMYMKIMLPNAMHT 720
KQCASAPCRNGGVCREGWNRFICDCIGTGFLGRVCEREATVLSYDGSMYMKIMLPNAMHT
Sbjct: 661 KQCASAPCRNGGVCREGWNRFICDCIGTGFLGRVCEREATVLSYDGSMYMKIMLPNAMHT 720
Query: 721 EAEDVSLRFMSQRAYGLMMATTSRESADTLRLELDGGQMKLTVNLGKGPETLFAGHKLND 780
EAEDVSLRFMSQRAYGLMMATTSRESADTLRLELDGGQMKLTVNLGKGPETLFAGHKLND
Sbjct: 721 EAEDVSLRFMSQRAYGLMMATTSRESADTLRLELDGGQMKLTVNLGKGPETLFAGHKLND 780
Query: 781 NEWHTVRVVRRGKSLQLSVDNVTVEGQMAGAHMRLEFHNIETGIMTERRFISVVPSNFIG 840
NEWHTVRVVRRGKSLQLSVDNVTVEGQMAGAHMRLEFHNIETGIMTERRFISVVPSNFIG
Sbjct: 781 NEWHTVRVVRRGKSLQLSVDNVTVEGQMAGAHMRLEFHNIETGIMTERRFISVVPSNFIG 840
Query: 841 HLSGLVFNGQPYMDQCKDGDITYCELNARFGLRAIVADPVTFKSRSSYLALATLQAYASM 900
HLSGLVFNGQPYMDQCKDGDITYCELNARFGLRAIVADPVTFKSRSSYLALATLQAYASM
Sbjct: 841 HLSGLVFNGQPYMDQCKDGDITYCELNARFGLRAIVADPVTFKSRSSYLALATLQAYASM 900
Query: 901 HLFFQFKTTAPDGLLLFNSGNGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQ 960
HLFFQFKTTAPDGLLLFNSGNGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQ
Sbjct: 901 HLFFQFKTTAPDGLLLFNSGNGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQ 960
Query: 961 WHNVVVSRDPGNVHTLKIDSRTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRD 1020
WHNVVVSRDPGNVHTLKIDSRTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRD
Sbjct: 961 WHNVVVSRDPGNVHTLKIDSRTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRD 1020
Query: 1021 GFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTC 1080
GFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTC
Sbjct: 1021 GFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTC 1080
Query: 1081 DCTMTSYGGPVCNDPGTTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVR 1140
DCTMTSYGGPVCNDPGTTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVR
Sbjct: 1081 DCTMTSYGGPVCNDPGTTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVR 1140
Query: 1141 VDSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQ 1200
VDSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQ
Sbjct: 1141 VDSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQ 1200
Query: 1201 VDSWPVNERYPAGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLKVLALAAESDPN 1260
VDSWPVNERYPAGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLKVLALAAESDPN
Sbjct: 1201 VDSWPVNERYPAGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLKVLALAAESDPN 1260
Query: 1261 VRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATTTTRRGRSPTLRDSTT 1320
VRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATTTTRRGRSPTLRDSTT
Sbjct: 1261 VRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATTTTRRGRSPTLRDSTT 1320
Query: 1321 QNTDDLLVASAECPSDDEDLEECEPSTGGELILPIITEDSLDPPPVATRSPFVPPPPTFY 1380
QNTDDLLVASAECPSDDEDLEECEPSTGGELILPIITEDSLDPPPVATRSPFVPPPPTFY
Sbjct: 1321 QNTDDLLVASAECPSDDEDLEECEPSTGGELILPIITEDSLDPPPVATRSPFVPPPPTFY 1380
Query: 1381 PFLTGVGATQDTLPPPAARRPPSGGPCQAERDDSDCEEPIEASGFASGEVFDSSLPPTDD 1440
PFLTGVGATQDTLPPPAARRPPSGGPCQAERDDSDCEEPIEASGFASGEVFDSSLPPTDD
Sbjct: 1381 PFLTGVGATQDTLPPPAARRPPSGGPCQAERDDSDCEEPIEASGFASGEVFDSSLPPTDD 1440
Query: 1441 EDFYTTFPLVTDRTTLLSPRKPAPRPNLRTDGATGAPGVLFAPSAPAPNLPAGKMNHRDP 1500
EDFYTTFPLVTDRTTLLSPRKPAPRPNLRTDGATGAPGVLFAPSAPAPNLPAGKMNHRDP
Sbjct: 1441 EDFYTTFPLVTDRTTLLSPRKPAPRPNLRTDGATGAPGVLFAPSAPAPNLPAGKMNHRDP 1500
Query: 1501 LQPLLENPPLGPGAPTSFEPRRPPPLRPGVTSAPGFPHLPTANPTGPGERGPPGAVEVIR 1560
LQPLLENPPLGPGAPTSFEPRRPPPLRPGVTSAPGFPHLPTANPTGPGERGPPGAVEVIR
Sbjct: 1501 LQPLLENPPLGPGAPTSFEPRRPPPLRPGVTSAPGFPHLPTANPTGPGERGPPGAVEVIR 1560
Query: 1561 ESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDQSRNYISNSAQSNGAVVKE 1620
ESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDQSRNYISNSAQSNGAVVKE
Sbjct: 1561 ESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDQSRNYISNSAQSNGAVVKE 1620
Query: 1621 KAPAAPKTPSKAKKNKDKEYYV 1642
KAPAAPKTPSKAKKNKDKEYYV
Sbjct: 1621 KAPAAPKTPSKAKKNKDKEYYV 1642
>gi|14211536 neurexin 2 isoform alpha-1 precursor [Homo sapiens]
Length = 1712
Score = 3294 bits (8540), Expect = 0.0
Identities = 1641/1712 (95%), Positives = 1641/1712 (95%), Gaps = 70/1712 (4%)
Query: 1 MASGSRWRPTPPPLLLLLLLALAARADGLEFGGGPGQWARYARWAGAASSGELSFSLRTN 60
MASGSRWRPTPPPLLLLLLLALAARADGLEFGGGPGQWARYARWAGAASSGELSFSLRTN
Sbjct: 1 MASGSRWRPTPPPLLLLLLLALAARADGLEFGGGPGQWARYARWAGAASSGELSFSLRTN 60
Query: 61 ATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDRWHMVLLTRD 120
ATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDRWHMVLLTRD
Sbjct: 61 ATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDRWHMVLLTRD 120
Query: 121 ARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLSTVKYEPPFRGLLA 180
ARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLSTVKYEPPFRGLLA
Sbjct: 121 ARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLSTVKYEPPFRGLLA 180
Query: 181 NLKLGERPPALLGSQGLRGATADPLCAPARNPCANGGLCTVLAPGEVGCDCSHTGFGGKF 240
NLKLGERPPALLGSQGLRGATADPLCAPARNPCANGGLCTVLAPGEVGCDCSHTGFGGKF
Sbjct: 181 NLKLGERPPALLGSQGLRGATADPLCAPARNPCANGGLCTVLAPGEVGCDCSHTGFGGKF 240
Query: 241 CSEEEHPMEGPAHLTLNSE------------------------GKEEFVATFKGNEFFCY 276
CSEEEHPMEGPAHLTLNSE GKEEFVATFKGNEFFCY
Sbjct: 241 CSEEEHPMEGPAHLTLNSEVGSLLFSEGGAGRGGAGDVHQPTKGKEEFVATFKGNEFFCY 300
Query: 277 DLSHNPIQSSTDEITLAFRTLQRNGLMLHTGKSADYVNLSLKSGAVWLVINLGSGAFEAL 336
DLSHNPIQSSTDEITLAFRTLQRNGLMLHTGKSADYVNLSLKSGAVWLVINLGSGAFEAL
Sbjct: 301 DLSHNPIQSSTDEITLAFRTLQRNGLMLHTGKSADYVNLSLKSGAVWLVINLGSGAFEAL 360
Query: 337 VEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMV-------TISVDGILTTTGYTQEDYTM 389
VEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMV TISVDGILTTTGYTQEDYTM
Sbjct: 361 VEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVTISVDGILTTTGYTQEDYTM 420
Query: 390 LGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEGDPKMKLQG 449
LGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEGDPKMKLQG
Sbjct: 421 LGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEGDPKMKLQG 480
Query: 450 DLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGG 509
DLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGG
Sbjct: 481 DLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGG 540
Query: 510 GAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKG 569
GAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKG
Sbjct: 541 GAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKG 600
Query: 570 SISVNSRSTPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRD 629
SISVNSRSTPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRD
Sbjct: 601 SISVNSRSTPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRD 660
Query: 630 LFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCREGWNRFICDCIGTG 689
LFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCREGWNRFICDCIGTG
Sbjct: 661 LFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCREGWNRFICDCIGTG 720
Query: 690 FLGRVCEREATVLSYDGSMYMKIMLPNAMHTEAEDVSLRFMSQRAYGLMMATTSRESADT 749
FLGRVCEREATVLSYDGSMYMKIMLPNAMHTEAEDVSLRFMSQRAYGLMMATTSRESADT
Sbjct: 721 FLGRVCEREATVLSYDGSMYMKIMLPNAMHTEAEDVSLRFMSQRAYGLMMATTSRESADT 780
Query: 750 LRLELDGGQMKLTVNL---------GKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVD 800
LRLELDGGQMKLTVNL KGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVD
Sbjct: 781 LRLELDGGQMKLTVNLDCLRVGCAPSKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVD 840
Query: 801 NVTVEGQMAGAHMRLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDGD 860
NVTVEGQMAGAHMRLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDGD
Sbjct: 841 NVTVEGQMAGAHMRLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDGD 900
Query: 861 ITYCELNARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSG 920
ITYCELNARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSG
Sbjct: 901 ITYCELNARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSG 960
Query: 921 NGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDS 980
NGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDS
Sbjct: 961 NGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDS 1020
Query: 981 RTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIA 1040
RTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIA
Sbjct: 1021 RTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIA 1080
Query: 1041 DALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYI 1100
DALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYI
Sbjct: 1081 DALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYI 1140
Query: 1101 FGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTV 1160
FGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTV
Sbjct: 1141 FGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTV 1200
Query: 1161 GVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPA-------- 1212
GVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPA
Sbjct: 1201 GVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNFDNERL 1260
Query: 1213 ----------------------GRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLKV 1250
GRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLKV
Sbjct: 1261 AIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLKV 1320
Query: 1251 LALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATTTTRRG 1310
LALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATTTTRRG
Sbjct: 1321 LALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATTTTRRG 1380
Query: 1311 RSPTLRDSTTQNTDDLLVASAECPSDDEDLEECEPSTGGELILPIITEDSLDPPPVATRS 1370
RSPTLRDSTTQNTDDLLVASAECPSDDEDLEECEPSTGGELILPIITEDSLDPPPVATRS
Sbjct: 1381 RSPTLRDSTTQNTDDLLVASAECPSDDEDLEECEPSTGGELILPIITEDSLDPPPVATRS 1440
Query: 1371 PFVPPPPTFYPFLTGVGATQDTLPPPAARRPPSGGPCQAERDDSDCEEPIEASGFASGEV 1430
PFVPPPPTFYPFLTGVGATQDTLPPPAARRPPSGGPCQAERDDSDCEEPIEASGFASGEV
Sbjct: 1441 PFVPPPPTFYPFLTGVGATQDTLPPPAARRPPSGGPCQAERDDSDCEEPIEASGFASGEV 1500
Query: 1431 FDSSLPPTDDEDFYTTFPLVTDRTTLLSPRKPAPRPNLRTDGATGAPGVLFAPSAPAPNL 1490
FDSSLPPTDDEDFYTTFPLVTDRTTLLSPRKPAPRPNLRTDGATGAPGVLFAPSAPAPNL
Sbjct: 1501 FDSSLPPTDDEDFYTTFPLVTDRTTLLSPRKPAPRPNLRTDGATGAPGVLFAPSAPAPNL 1560
Query: 1491 PAGKMNHRDPLQPLLENPPLGPGAPTSFEPRRPPPLRPGVTSAPGFPHLPTANPTGPGER 1550
PAGKMNHRDPLQPLLENPPLGPGAPTSFEPRRPPPLRPGVTSAPGFPHLPTANPTGPGER
Sbjct: 1561 PAGKMNHRDPLQPLLENPPLGPGAPTSFEPRRPPPLRPGVTSAPGFPHLPTANPTGPGER 1620
Query: 1551 GPPGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDQSRNYISNS 1610
GPPGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDQSRNYISNS
Sbjct: 1621 GPPGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDQSRNYISNS 1680
Query: 1611 AQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV 1642
AQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV
Sbjct: 1681 AQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV 1712
>gi|14149613 neurexin 1 isoform alpha1 precursor [Homo sapiens]
Length = 1477
Score = 1900 bits (4923), Expect = 0.0
Identities = 934/1369 (68%), Positives = 1118/1369 (81%), Gaps = 43/1369 (3%)
Query: 14 LLLLLLLALAARADGLEFGGGPGQWARYARWAGAASSGELSFSLRTNATRALLLYLDDGG 73
L LLLL A GLEF G GQW R+ +W A E+SF L+T + R L+LY DD G
Sbjct: 16 LSLLLLGCWAELGSGLEFPGAEGQWTRFPKW-NACCESEMSFQLKTRSARGLVLYFDDEG 74
Query: 74 DCDFLELLLV-DGRLRLRFTLSCAEPATLQLDTPVADDRWHMVLLTRDARRTALAVDG-E 131
CDFLEL+L GRL+L F++ CAEPATL DTPV D WH V + R R T L +D E
Sbjct: 75 FCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVE 134
Query: 132 ARAAEVRSKRREMQVASDLFVGGIPPDVRLSAL--TLSTVKYEPPFRGLLANL------- 182
A+ EV+SKRR+M V S LFVGG+PP++R +AL TL++V+ PF+G + ++
Sbjct: 135 AKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQV 194
Query: 183 --------KLGERPPALLGSQGLRGATADPLCAPARNPCANGGLCTVLAPGEVGCDCSHT 234
KL + PP G G+ + C NGG+C+V+ V CDCS T
Sbjct: 195 LPVDSGEVKLDDEPPNSGG-----GSPCEAGEEGEGGVCLNGGVCSVVDDQAV-CDCSRT 248
Query: 235 GFGGKFCSEEEHPMEGPAHLTLN----SEGKEEFVATFKGNEFFCYDLSHNPIQSSTDEI 290
GF GK CS+E++ +EG AHL + S+GKEE++ATFKG+E+FCYDLS NPIQSS+DEI
Sbjct: 249 GFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNPIQSSSDEI 308
Query: 291 TLAFRTLQRNGLMLHTGKSADYVNLSLKSGAVWLVINLGSGAFEALVEPVNGKFNDNAWH 350
TL+F+TLQRNGLMLHTGKSADYVNL+LK+GAV LVINLGSGAFEALVEPVNGKFNDNAWH
Sbjct: 309 TLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDNAWH 368
Query: 351 DVRVTRNLRQHAGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGS 410
DV+VTRNLRQH+GIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFY+GGSP+TADLPGS
Sbjct: 369 DVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGS 428
Query: 411 PVSNNFMGCLKDVVYKNNDFKLELSRLAKEGDPKMKLQGDLSFRCEDVAALDPVTFESPE 470
PVSNNFMGCLK+VVYKNND +LELSRLAK+GDPKMK+ G ++F+CE+VA LDP+TFE+PE
Sbjct: 429 PVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPE 488
Query: 471 AFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDG 530
+F++LP+W+AK+TGSIS DFRTTEPNGL+LFS G+ H + D+FA+E+LDG
Sbjct: 489 SFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDG 548
Query: 531 HLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNSRSTPFLATGDSEILD 590
HLYLLLDMGSG IK++A +KVNDGEW HVDFQRDGR G+ISVN+ TP+ A G+SEILD
Sbjct: 549 HLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILD 608
Query: 591 LESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVG 650
L+ ELYLGGLPE + L P EVWTA L GYVGC+RDLFIDG+S+D+R +AE Q G
Sbjct: 609 LDDELYLGGLPEN-KAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAG 667
Query: 651 VAPFCSRETLKQCASAPCRNGGVCREGWNRFICDCIGTGFLGRVCEREATVLSYDGSMYM 710
V P CS+ET K C S PC+N G+CR+GWNR++CDC GTG+LGR CEREATVLSYDGSM+M
Sbjct: 668 VKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFM 727
Query: 711 KIMLPNAMHTEAEDVSLRFMSQRAYGLMMATTSRESADTLRLELDGGQMKLTVNL----- 765
KI LP MHTEAEDVSLRF SQRAYG++MATTSR+SADTLRLELD G++KLTVNL
Sbjct: 728 KIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRI 787
Query: 766 ----GKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDNV-TVEGQMAGAHMRLEFHNI 820
KGPETLFAG+ LNDNEWHTVRVVRRGKSL+L+VD+ + GQMAG H RLEFHNI
Sbjct: 788 NCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNI 847
Query: 821 ETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDGDITYCELNARFGLRAIVADPV 880
ETGI+TERR++S VPSNFIGHL L FNG Y+D CK+GDI YCELNARFG R I+ADPV
Sbjct: 848 ETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIADPV 907
Query: 881 TFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSGNGNDFIVIELVKGYIHYVFD 940
TFK++SSY+ALATLQAY SMHLFFQFKTT+ DGL+L+NSG+GNDFIV+ELVKGY+HYVFD
Sbjct: 908 TFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFD 967
Query: 941 LGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGARNLDLKGELY 1000
LGNG +L+KG+S+KP+NDNQWHNV++SRD N+HT+KID++ TQ + GARNLDLK +LY
Sbjct: 968 LGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNLDLKSDLY 1027
Query: 1001 IGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPSTTC 1060
IGG++K + +LPKLV +++GFQGCLASVDLNGRLPDLI+DAL GQ+ERGC+GPSTTC
Sbjct: 1028 IGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTC 1087
Query: 1061 TEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALITYTWPPNDRPST 1120
E+SC+NQGVCLQQWDGF+CDC+MTS+ GP+CNDPGTTYIF KGG ITY WPPNDRPST
Sbjct: 1088 QEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPST 1147
Query: 1121 RMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEPNAIV 1180
R DRLA+GFST Q+ AVLVRVDS+SGLGDYL+LHI QG +GV FNVGTDDI I+E NAI+
Sbjct: 1148 RADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAII 1207
Query: 1181 SDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGRQLTIFNSQAAIKIGGRDQGRPFQGQV 1240
+DGKYHVVRFTRSGGNATLQVDSWPV ERYPAGRQLTIFNSQA I IGG++QG+PFQGQ+
Sbjct: 1208 NDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGRQLTIFNSQATIIIGGKEQGQPFQGQL 1267
Query: 1241 SGLYYNGLKVLALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTT 1300
SGLYYNGLKVL +AAE+D N+ G++RLVGE PS ++ E+TAT + ++M+T+IMETTT
Sbjct: 1268 SGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPS-SMTTESTATAMQSEMSTSIMETTT 1326
Query: 1301 TMATTTTRRGRSPTLRDSTTQNTDDLLVASAECPSDDEDLEECEPSTGG 1349
T+AT+T RRG+ PT ++ +Q TDD+LVASAECPSDDED++ CEPS+GG
Sbjct: 1327 TLATSTARRGKPPT-KEPISQTTDDILVASAECPSDDEDIDPCEPSSGG 1374
Score = 164 bits (416), Expect = 5e-40
Identities = 85/102 (83%), Positives = 91/102 (89%), Gaps = 1/102 (0%)
Query: 1542 ANPTGPGERGP-PGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQV 1600
ANPT G R P PG+ EVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSY V
Sbjct: 1376 ANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHV 1435
Query: 1601 DQSRNYISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV 1642
D+SRNYISNSAQSNGAVVKEK P++ K+ +K KKNKDKEYYV
Sbjct: 1436 DESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV 1477
>gi|208609951 neurexin 1 isoform alpha2 precursor [Homo sapiens]
Length = 1547
Score = 1861 bits (4820), Expect = 0.0
Identities = 934/1439 (64%), Positives = 1118/1439 (77%), Gaps = 113/1439 (7%)
Query: 14 LLLLLLLALAARADGLEFGGGPGQWARYARWAGAASSGELSFSLRTNATRALLLYLDDGG 73
L LLLL A GLEF G GQW R+ +W A E+SF L+T + R L+LY DD G
Sbjct: 16 LSLLLLGCWAELGSGLEFPGAEGQWTRFPKW-NACCESEMSFQLKTRSARGLVLYFDDEG 74
Query: 74 DCDFLELLLV-DGRLRLRFTLSCAEPATLQLDTPVADDRWHMVLLTRDARRTALAVDG-E 131
CDFLEL+L GRL+L F++ CAEPATL DTPV D WH V + R R T L +D E
Sbjct: 75 FCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVE 134
Query: 132 ARAAEVRSKRREMQVASDLFVGGIPPDVRLSAL--TLSTVKYEPPFRGLLANL------- 182
A+ EV+SKRR+M V S LFVGG+PP++R +AL TL++V+ PF+G + ++
Sbjct: 135 AKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQV 194
Query: 183 --------KLGERPPALLGSQGLRGATADPLCAPARNPCANGGLCTVLAPGEVGCDCSHT 234
KL + PP G G+ + C NGG+C+V+ V CDCS T
Sbjct: 195 LPVDSGEVKLDDEPPNSGG-----GSPCEAGEEGEGGVCLNGGVCSVVDDQAV-CDCSRT 248
Query: 235 GFGGKFCSEE---------------------------------EHPMEGPAHLTLN---- 257
GF GK CS+E ++ +EG AHL +
Sbjct: 249 GFRGKDCSQEIKFGLQCVLPVLLHDNDQGKYCCINTAKPLTEKDNNVEGLAHLMMGDQGK 308
Query: 258 SEGKEEFVATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHTGKSADYVNLSL 317
S+GKEE++ATFKG+E+FCYDLS NPIQSS+DEITL+F+TLQRNGLMLHTGKSADYVNL+L
Sbjct: 309 SKGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLAL 368
Query: 318 KSGAVWLVINLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMV-------T 370
K+GAV LVINLGSGAFEALVEPVNGKFNDNAWHDV+VTRNLRQH+GIGHAMV T
Sbjct: 369 KNGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVT 428
Query: 371 ISVDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDF 430
ISVDGILTTTGYTQEDYTMLGSDDFFY+GGSP+TADLPGSPVSNNFMGCLK+VVYKNND
Sbjct: 429 ISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDV 488
Query: 431 KLELSRLAKEGDPKMKLQGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDF 490
+LELSRLAK+GDPKMK+ G ++F+CE+VA LDP+TFE+PE+F++LP+W+AK+TGSIS DF
Sbjct: 489 RLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPESFISLPKWNAKKTGSISFDF 548
Query: 491 RTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSR 550
RTTEPNGL+LFS G+ H + D+FA+E+LDGHLYLLLDMGSG IK++A +
Sbjct: 549 RTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLK 608
Query: 551 KVNDGEWCHVDFQRDGRKGSISVNSRSTPFLATGDSEILDLESELYLGGLPEGGRVDLPL 610
KVNDGEW HVDFQRDGR G+ISVN+ TP+ A G+SEILDL+ ELYLGGLPE + L
Sbjct: 609 KVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPEN-KAGLVF 667
Query: 611 PPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAPCRN 670
P EVWTA L GYVGC+RDLFIDG+S+D+R +AE Q GV P CS+ET K C S PC+N
Sbjct: 668 PTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPCLSNPCKN 727
Query: 671 GGVCREGWNRFICDCIGTGFLGRVCEREATVLSYDGSMYMKIMLPNAMHTEAEDVSLRFM 730
G+CR+GWNR++CDC GTG+LGR CEREATVLSYDGSM+MKI LP MHTEAEDVSLRF
Sbjct: 728 NGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDVSLRFR 787
Query: 731 SQRAYGLMMATTSRESADTLRLELDGGQMKLTVNL---------GKGPETLFAGHKLNDN 781
SQRAYG++MATTSR+SADTLRLELD G++KLTVNL KGPETLFAG+ LNDN
Sbjct: 788 SQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDN 847
Query: 782 EWHTVRVVRRGKSLQLSVDNV-TVEGQMAGAHMRLEFHNIETGIMTERRFISVVPSNFIG 840
EWHTVRVVRRGKSL+L+VD+ + GQMAG H RLEFHNIETGI+TERR++S VPSNFIG
Sbjct: 848 EWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETGIITERRYLSSVPSNFIG 907
Query: 841 HLSGLVFNGQPYMDQCKDGDITYCELNARFGLRAIVADPVTFKSRSSYLALATLQAYASM 900
HL L FNG Y+D CK+GDI YCELNARFG R I+ADPVTFK++SSY+ALATLQAY SM
Sbjct: 908 HLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIADPVTFKTKSSYVALATLQAYTSM 967
Query: 901 HLFFQFKTTAPDGLLLFNSGNGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQ 960
HLFFQFKTT+ DGL+L+NSG+GNDFIV+ELVKGY+HYVFDLGNG +L+KG+S+KP+NDNQ
Sbjct: 968 HLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQ 1027
Query: 961 WHNVVVSRDPGNVHTLKIDSRTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRD 1020
WHNV++SRD N+HT+KID++ TQ + GARNLDLK +LYIGG++K + +LPKLV +++
Sbjct: 1028 WHNVMISRDTSNLHTVKIDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKE 1087
Query: 1021 GFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTC 1080
GFQGCLASVDLNGRLPDLI+DAL GQ+ERGC+GPSTTC E+SC+NQGVCLQQWDGF+C
Sbjct: 1088 GFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSC 1147
Query: 1081 DCTMTSYGGPVCNDPGTTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVR 1140
DC+MTS+ GP+CNDPGTTYIF KGG ITY WPPNDRPSTR DRLA+GFST Q+ AVLVR
Sbjct: 1148 DCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVR 1207
Query: 1141 VDSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQ 1200
VDS+SGLGDYL+LHI QG +GV FNVGTDDI I+E NAI++DGKYHVVRFTRSGGNATLQ
Sbjct: 1208 VDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQ 1267
Query: 1201 VDSWPVNERYPA------------------------------GRQLTIFNSQAAIKIGGR 1230
VDSWPV ERYPA GRQLTIFNSQA I IGG+
Sbjct: 1268 VDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQATIIIGGK 1327
Query: 1231 DQGRPFQGQVSGLYYNGLKVLALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLAD 1290
+QG+PFQGQ+SGLYYNGLKVL +AAE+D N+ G++RLVGE PS ++ E+TAT + ++
Sbjct: 1328 EQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPS-SMTTESTATAMQSE 1386
Query: 1291 MATTIMETTTTMATTTTRRGRSPTLRDSTTQNTDDLLVASAECPSDDEDLEECEPSTGG 1349
M+T+IMETTTT+AT+T RRG+ PT ++ +Q TDD+LVASAECPSDDED++ CEPS+GG
Sbjct: 1387 MSTSIMETTTTLATSTARRGKPPT-KEPISQTTDDILVASAECPSDDEDIDPCEPSSGG 1444
Score = 164 bits (416), Expect = 5e-40
Identities = 85/102 (83%), Positives = 91/102 (89%), Gaps = 1/102 (0%)
Query: 1542 ANPTGPGERGP-PGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQV 1600
ANPT G R P PG+ EVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSY V
Sbjct: 1446 ANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHV 1505
Query: 1601 DQSRNYISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV 1642
D+SRNYISNSAQSNGAVVKEK P++ K+ +K KKNKDKEYYV
Sbjct: 1506 DESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV 1547
>gi|21070969 neurexin 3 isoform 1 precursor [Homo sapiens]
Length = 1061
Score = 1437 bits (3721), Expect = 0.0
Identities = 686/968 (70%), Positives = 814/968 (84%), Gaps = 16/968 (1%)
Query: 389 MLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEGDPKMKLQ 448
MLGSDDFFY+GGSP+TADLPGSPVSNNFMGCLK+VVYKNND +LELSRLA+ D KMK+
Sbjct: 1 MLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDIRLELSRLARIADTKMKIY 60
Query: 449 GDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAG 508
G++ F+CE+VA LDP+ FE+PEA+++LP+W+ KR GSIS DFRTTEPNGL+LF+ G+
Sbjct: 61 GEVVFKCENVATLDPINFETPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQE 120
Query: 509 GGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRK 568
+ D+FA+ELLDG+LYLLLDMGSG IK++A+ +K NDGEW HVD QRDGR
Sbjct: 121 RKDARSQKNTKVDFFAVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQRDGRS 180
Query: 569 GSISVNSRSTPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVR 628
G+ISVNSR TPF A+G+SEILDLE ++YLGGLPE R L LP E+WTA L GYVGC+R
Sbjct: 181 GTISVNSRRTPFTASGESEILDLEGDMYLGGLPEN-RAGLILPTELWTAMLNYGYVGCIR 239
Query: 629 DLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCREGWNRFICDCIGT 688
DLFIDGRS+++R LAE Q A GV CSR + KQC S PC+N VC++GWNRFICDC GT
Sbjct: 240 DLFIDGRSKNIRQLAEMQNAAGVKSSCSRMSAKQCDSYPCKNNAVCKDGWNRFICDCTGT 299
Query: 689 GFLGRVCEREATVLSYDGSMYMKIMLPNAMHTEAEDVSLRFMSQRAYGLMMATTSRESAD 748
G+ GR CEREA++LSYDGSMYMKI++P MHTEAEDVS RFMSQRAYGL++ATTSR+SAD
Sbjct: 300 GYWGRTCEREASILSYDGSMYMKIIMPMVMHTEAEDVSFRFMSQRAYGLLVATTSRDSAD 359
Query: 749 TLRLELDGGQMKLTVNL---------GKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSV 799
TLRLELDGG++KL VNL KGPETL+AG KLNDNEWHTVRVVRRGKSL+L+V
Sbjct: 360 TLRLELDGGRVKLMVNLDCIRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTV 419
Query: 800 DNVTVEGQMAGAHMRLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDG 859
D+ EG M G H RLEFHNIETGIMTE+R+ISVVPS+FIGHL L+FNG Y+D CK+G
Sbjct: 420 DDDVAEGTMVGDHTRLEFHNIETGIMTEKRYISVVPSSFIGHLQSLMFNGLLYIDLCKNG 479
Query: 860 DITYCELNARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNS 919
DI YCEL ARFGLR I+ADPVTFK++SSYL+LATLQAY SMHLFFQFKTT+PDG +LFNS
Sbjct: 480 DIDYCELKARFGLRNIIADPVTFKTKSSYLSLATLQAYTSMHLFFQFKTTSPDGFILFNS 539
Query: 920 GNGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKID 979
G+GNDFI +ELVKGYIHYVFDLGNGP+++KGNSD+P+NDNQWHNVV++RD N H+LK+D
Sbjct: 540 GDGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSDRPLNDNQWHNVVITRDNSNTHSLKVD 599
Query: 980 SRTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLI 1039
++ VTQ NGA+NLDLKG+LY+ GL++ M+SNLPKLVASRDGFQGCLASVDLNGRLPDLI
Sbjct: 600 TKVVTQVINGAKNLDLKGDLYMAGLAQGMYSNLPKLVASRDGFQGCLASVDLNGRLPDLI 659
Query: 1040 ADALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTY 1099
DALHR GQ+ERGC+GPSTTC E+SCANQGVC+QQW+GFTCDC+MTSY G CNDPG TY
Sbjct: 660 NDALHRSGQIERGCEGPSTTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQCNDPGATY 719
Query: 1100 IFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGT 1159
IFGK G LI YTWP NDRPSTR DRLAVGFST + +LVR+DSA GLGD+LQLHI+QG
Sbjct: 720 IFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGK 779
Query: 1160 VGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGRQLTIF 1219
+GV+FN+GT DI+I E V+DGKYHVVRFTR+GGNATLQVD+WPVNE YP GRQLTIF
Sbjct: 780 IGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGRQLTIF 839
Query: 1220 NSQAAIKIGGRDQGRPFQGQVSGLYYNGLKVLALAAESDPNVRTEGHLRLVGEGPSVLLS 1279
N+QA I IGG+D+GR FQGQ+SGLYY+GLKVL +AAE++PN++ G +RLVGE PS+L +
Sbjct: 840 NTQAQIAIGGKDKGRLFQGQLSGLYYDGLKVLNMAAENNPNIKINGSVRLVGEVPSILGT 899
Query: 1280 AETTATTLLADMATTIMETTTTMATTTTRRGRSPTLRDSTTQNTDDLLVASAECPSDDED 1339
+T T++ +M+TT+METTTTMATTTTR+ RS ++ Q T D LV+SAEC SDDED
Sbjct: 900 TQT--TSMPPEMSTTVMETTTTMATTTTRKNRS----TASIQPTSDDLVSSAECSSDDED 953
Query: 1340 LEECEPST 1347
ECEPST
Sbjct: 954 FVECEPST 961
Score = 181 bits (460), Expect = 4e-45
Identities = 199/851 (23%), Positives = 345/851 (40%), Gaps = 109/851 (12%)
Query: 51 GELSFSLRTNATRALLLYL------------DDGGDCDFLELLLVDGRLRLRFTLSCAEP 98
G +SF RT L+L+ DF + L+DG L L +
Sbjct: 96 GSISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFAVELLDGNLYLLLDMGSGTI 155
Query: 99 ATLQLDTPVADDRWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPD 158
D W+ V + RD R ++V+ + + + D+++GG+P +
Sbjct: 156 KVKATQKKANDGEWYHVDIQRDGRSGTISVNSRRTPFTASGESEILDLEGDMYLGGLPEN 215
Query: 159 VR--LSALTLSTVKYEPPFRGLLANLKLGERPP---ALLGSQGLRGATADPLCAPARN-- 211
+ L T + G + +L + R L Q G + A+
Sbjct: 216 RAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEMQNAAGVKSSCSRMSAKQCD 275
Query: 212 --PCANGGLCTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEGKEEFVATFK 269
PC N +C CDC+ TG+ G+ C +E + ++
Sbjct: 276 SYPCKNNAVCKD-GWNRFICDCTGTGYWGRTCE------------------REASILSYD 316
Query: 270 GNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHTGK--SADYVNLSLKSGAVWLVIN 327
G+ + + + + ++++ F + + GL++ T SAD + L L G V L++N
Sbjct: 317 GS-MYMKIIMPMVMHTEAEDVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVN 375
Query: 328 L--------GSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVTISVDGILTT 379
L S E L K NDN WH VRV R + +T+ D
Sbjct: 376 LDCIRINCNSSKGPETLY--AGQKLNDNEWHTVRVVRRGKS------LKLTVDDD---VA 424
Query: 380 TGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAK 439
G D+T L +F I T S V ++F+G L+ +++ L L K
Sbjct: 425 EGTMVGDHTRL---EFHNIETGIMTEKRYISVVPSSFIGHLQSLMFNG----LLYIDLCK 477
Query: 440 EGDPKMKLQGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLL 499
GD + F ++ A DPVTF++ ++++L A + + F+TT P+G +
Sbjct: 478 NGDIDY-CELKARFGLRNIIA-DPVTFKTKSSYLSLATLQAYTSMHLFFQFKTTSPDGFI 535
Query: 500 LFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASS-RKVNDGEWC 558
LF+ G D+ A+EL+ G+++ + D+G+G ++ +S R +ND +W
Sbjct: 536 LFNSG-------------DGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSDRPLNDNQWH 582
Query: 559 HVDFQRD-GRKGSISVNSRSTPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTA 617
+V RD S+ V+++ + G ++ LDL+ +LY+ GL +G +LP
Sbjct: 583 NVVITRDNSNTHSLKVDTKVVTQVING-AKNLDLKGDLYMAGLAQGMYSNLPK-----LV 636
Query: 618 ALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCREG 677
A R G+ GC+ + ++GR DL + +A G C C N GVC +
Sbjct: 637 ASRDGFQGCLASVDLNGRLPDL--INDALHRSGQIERGCEGPSTTCQEDSCANQGVCMQQ 694
Query: 678 WNRFICDCIGTGFLGRVCEREAT--VLSYDGSMYMKIMLPN-AMHTEAEDVSLRFMSQRA 734
W F CDC T + G C + G + + N T ++ +++ F +
Sbjct: 695 WEGFTCDCSMTSYSGNQCNDPGATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVK 754
Query: 735 YGLMMATTSRES-ADTLRLELDGGQMKLTVNLGKGPETLFAGH-KLNDNEWHTVRVVRRG 792
G+++ S D L+L ++ G++ + N+G ++ +ND ++H VR R G
Sbjct: 755 DGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNG 814
Query: 793 KSLQLSVDNVTVEGQMAGAHMRLEFH---NIETGIMTERRFISVVPSNFIGHLSGLVFNG 849
+ L VDN V F+ I G + R F G LSGL ++G
Sbjct: 815 GNATLQVDNWPVNEHYPTGRQLTIFNTQAQIAIGGKDKGRL-------FQGQLSGLYYDG 867
Query: 850 QPYMDQCKDGD 860
++ + +
Sbjct: 868 LKVLNMAAENN 878
Score = 157 bits (396), Expect = 1e-37
Identities = 81/102 (79%), Positives = 90/102 (88%), Gaps = 1/102 (0%)
Query: 1541 TANPTGPGERGPPGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQV 1600
TANPT PG R PGA EVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQV
Sbjct: 961 TANPTEPGIRRVPGASEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQV 1020
Query: 1601 DQSRNYISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV 1642
D++RNYISNSAQSNG ++KEK ++ K+ K +KNKD+EYYV
Sbjct: 1021 DETRNYISNSAQSNGTLMKEKQQSS-KSGHKKQKNKDREYYV 1061
Score = 39.3 bits (90), Expect = 0.032
Identities = 23/81 (28%), Positives = 40/81 (49%), Gaps = 1/81 (1%)
Query: 50 SGELSFSLRTNATRALLLYLDDG-GDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVA 108
S L+ T +L+ +D G DFL+L + G++ + F + + + + TPV
Sbjct: 742 SDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVN 801
Query: 109 DDRWHMVLLTRDARRTALAVD 129
D ++H+V TR+ L VD
Sbjct: 802 DGKYHVVRFTRNGGNATLQVD 822
>gi|21166382 neurexin 2 isoform beta precursor [Homo sapiens]
Length = 666
Score = 1095 bits (2833), Expect = 0.0
Identities = 547/577 (94%), Positives = 547/577 (94%), Gaps = 30/577 (5%)
Query: 1096 GTTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHI 1155
GTTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHI
Sbjct: 90 GTTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHI 149
Query: 1156 DQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPA--- 1212
DQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPA
Sbjct: 150 DQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNF 209
Query: 1213 ---------------------------GRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYY 1245
GRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYY
Sbjct: 210 DNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYY 269
Query: 1246 NGLKVLALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATT 1305
NGLKVLALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATT
Sbjct: 270 NGLKVLALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATT 329
Query: 1306 TTRRGRSPTLRDSTTQNTDDLLVASAECPSDDEDLEECEPSTGGELILPIITEDSLDPPP 1365
TTRRGRSPTLRDSTTQNTDDLLVASAECPSDDEDLEECEPSTGGELILPIITEDSLDPPP
Sbjct: 330 TTRRGRSPTLRDSTTQNTDDLLVASAECPSDDEDLEECEPSTGGELILPIITEDSLDPPP 389
Query: 1366 VATRSPFVPPPPTFYPFLTGVGATQDTLPPPAARRPPSGGPCQAERDDSDCEEPIEASGF 1425
VATRSPFVPPPPTFYPFLTGVGATQDTLPPPAARRPPSGGPCQAERDDSDCEEPIEASGF
Sbjct: 390 VATRSPFVPPPPTFYPFLTGVGATQDTLPPPAARRPPSGGPCQAERDDSDCEEPIEASGF 449
Query: 1426 ASGEVFDSSLPPTDDEDFYTTFPLVTDRTTLLSPRKPAPRPNLRTDGATGAPGVLFAPSA 1485
ASGEVFDSSLPPTDDEDFYTTFPLVTDRTTLLSPRKPAPRPNLRTDGATGAPGVLFAPSA
Sbjct: 450 ASGEVFDSSLPPTDDEDFYTTFPLVTDRTTLLSPRKPAPRPNLRTDGATGAPGVLFAPSA 509
Query: 1486 PAPNLPAGKMNHRDPLQPLLENPPLGPGAPTSFEPRRPPPLRPGVTSAPGFPHLPTANPT 1545
PAPNLPAGKMNHRDPLQPLLENPPLGPGAPTSFEPRRPPPLRPGVTSAPGFPHLPTANPT
Sbjct: 510 PAPNLPAGKMNHRDPLQPLLENPPLGPGAPTSFEPRRPPPLRPGVTSAPGFPHLPTANPT 569
Query: 1546 GPGERGPPGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDQSRN 1605
GPGERGPPGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDQSRN
Sbjct: 570 GPGERGPPGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDQSRN 629
Query: 1606 YISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV 1642
YISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV
Sbjct: 630 YISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV 666
Score = 41.2 bits (95), Expect = 0.008
Identities = 46/202 (22%), Positives = 81/202 (40%), Gaps = 26/202 (12%)
Query: 269 KGNEFFCYDLSHNPIQSST-DEITLAFRTLQRNGLMLHTGKSA---DYVNLSLKSGAVWL 324
KG Y N S+ D + + F T QR+ +++ ++ DY+ L + G V +
Sbjct: 97 KGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGV 156
Query: 325 VINLGSGAFEALVEPVNGKFNDNAWHDVRVTR--------------NLRQHAG-IGHAMV 369
+ N+G+ + ++ N +D +H VR TR N R AG + +
Sbjct: 157 IFNVGTD--DITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNFDNERL 214
Query: 370 TISVDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNND 429
I+ I G +++ +L I S + G F G + + Y
Sbjct: 215 AIARQRIPYRLGRVVDEW-LLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNG-- 271
Query: 430 FKLELSRLAKEGDPKMKLQGDL 451
L++ LA E DP ++ +G L
Sbjct: 272 --LKVLALAAESDPNVRTEGHL 291
Score = 34.7 bits (78), Expect = 0.78
Identities = 34/156 (21%), Positives = 67/156 (42%), Gaps = 27/156 (17%)
Query: 732 QRAYGLMMATTSRESADTLRLELDGGQMKLTVNLGKGPETLFAGHKL-NDNEWHTVRVVR 790
QR+ L+ ++ D L+L +D G + + N+G T+ + + +D ++H VR R
Sbjct: 127 QRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTR 186
Query: 791 RGKSLQLSVDNVTV----------EGQMAGAHMRLEF---HNIETGIMTERRFISVVPSN 837
G + L VD+ V ++A A R+ + ++ ++ + R +++ S
Sbjct: 187 SGGNATLQVDSWPVNERYPAGNFDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQ 246
Query: 838 -------------FIGHLSGLVFNGQPYMDQCKDGD 860
F G +SGL +NG + + D
Sbjct: 247 AAIKIGGRDQGRPFQGQVSGLYYNGLKVLALAAESD 282
>gi|21070967 neurexin 1 isoform beta precursor [Homo sapiens]
Length = 442
Score = 382 bits (981), Expect = e-105
Identities = 186/254 (73%), Positives = 221/254 (87%), Gaps = 2/254 (0%)
Query: 1096 GTTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHI 1155
GTTYIF KGG ITY WPPNDRPSTR DRLA+GFST Q+ AVLVRVDS+SGLGDYL+LHI
Sbjct: 88 GTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHI 147
Query: 1156 DQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGRQ 1215
QG +GV FNVGTDDI I+E NAI++DGKYHVVRFTRSGGNATLQVDSWPV ERYPAGRQ
Sbjct: 148 HQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGRQ 207
Query: 1216 LTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLKVLALAAESDPNVRTEGHLRLVGEGPS 1275
LTIFNSQA I IGG++QG+PFQGQ+SGLYYNGLKVL +AAE+D N+ G++RLVGE PS
Sbjct: 208 LTIFNSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPS 267
Query: 1276 VLLSAETTATTLLADMATTIMETTTTMATTTTRRGRSPTLRDSTTQNTDDLLVASAECPS 1335
++ E+TAT + ++M+T+IMETTTT+AT+T RRG+ PT ++ +Q TDD+LVASAECPS
Sbjct: 268 -SMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPT-KEPISQTTDDILVASAECPS 325
Query: 1336 DDEDLEECEPSTGG 1349
DDED++ CEPS+GG
Sbjct: 326 DDEDIDPCEPSSGG 339
Score = 164 bits (416), Expect = 5e-40
Identities = 85/102 (83%), Positives = 91/102 (89%), Gaps = 1/102 (0%)
Query: 1542 ANPTGPGERGP-PGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQV 1600
ANPT G R P PG+ EVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSY V
Sbjct: 341 ANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHV 400
Query: 1601 DQSRNYISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV 1642
D+SRNYISNSAQSNGAVVKEK P++ K+ +K KKNKDKEYYV
Sbjct: 401 DESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV 442
Score = 42.7 bits (99), Expect = 0.003
Identities = 40/168 (23%), Positives = 68/168 (40%), Gaps = 27/168 (16%)
Query: 288 DEITLAFRTLQRNGLMLHTGKSA---DYVNLSLKSGAVWLVINLGSGAFEALVEPVNGKF 344
D + + F T+Q+ +++ S+ DY+ L + G + + N+G+ + +E N
Sbjct: 115 DRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTD--DIAIEESNAII 172
Query: 345 NDNAWHDVRVTRNLRQHAGIGHAMVTISVDGILTTTGY-TQEDYTMLGSDDFFYIGGSPN 403
ND +H VR TR+ T+ VD Y T+ S IGG
Sbjct: 173 NDGKYHVVRFTRS--------GGNATLQVDSWPVIERYPAGRQLTIFNSQATIIIGGKEQ 224
Query: 404 TADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEGDPKMKLQGDL 451
G P F G L + Y L++ +A E D + + G++
Sbjct: 225 -----GQP----FQGQLSGLYYNG----LKVLNMAAENDANIAIVGNV 259
Score = 41.6 bits (96), Expect = 0.006
Identities = 37/144 (25%), Positives = 68/144 (47%), Gaps = 8/144 (5%)
Query: 720 TEAEDVSLRFMS-QRAYGLMMATTSRESADTLRLELDGGQMKLTVNLGKGPETLFAGHKL 778
T A+ +++ F + Q+ L+ +S D L L + G++ + N+G + + +
Sbjct: 112 TRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAI 171
Query: 779 -NDNEWHTVRVVRRGKSLQLSVDN-VTVEGQMAGAHMRLEFHNIETGIMTERRFISVVPS 836
ND ++H VR R G + L VD+ +E AG + + F++ T I+ +
Sbjct: 172 INDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGRQLTI-FNSQATIIIGGKE----QGQ 226
Query: 837 NFIGHLSGLVFNGQPYMDQCKDGD 860
F G LSGL +NG ++ + D
Sbjct: 227 PFQGQLSGLYYNGLKVLNMAAEND 250
Score = 36.2 bits (82), Expect = 0.27
Identities = 22/91 (24%), Positives = 45/91 (49%), Gaps = 2/91 (2%)
Query: 515 SSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVN 574
SS+ DY + + G + + ++G+ I + S+ +NDG++ V F R G ++ V+
Sbjct: 135 SSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVD 194
Query: 575 SRST--PFLATGDSEILDLESELYLGGLPEG 603
S + A I + ++ + +GG +G
Sbjct: 195 SWPVIERYPAGRQLTIFNSQATIIIGGKEQG 225
Score = 34.7 bits (78), Expect = 0.78
Identities = 21/78 (26%), Positives = 39/78 (50%), Gaps = 1/78 (1%)
Query: 53 LSFSLRTNATRALLLYLDDG-GDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDR 111
L+ T A+L+ +D G D+LEL + G++ ++F + + A + + + D +
Sbjct: 117 LAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGK 176
Query: 112 WHMVLLTRDARRTALAVD 129
+H+V TR L VD
Sbjct: 177 YHVVRFTRSGGNATLQVD 194
>gi|41350305 neurexin 3 isoform 2 precursor [Homo sapiens]
Length = 432
Score = 347 bits (889), Expect = 7e-95
Identities = 171/253 (67%), Positives = 206/253 (81%), Gaps = 6/253 (2%)
Query: 1096 GTTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHI 1155
G TYIFGK G LI YTWP NDRPSTR DRLAVGFST + +LVR+DSA GLGD+LQLHI
Sbjct: 84 GATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHI 143
Query: 1156 DQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGRQ 1215
+QG +GV+FN+GT DI+I E V+DGKYHVVRFTR+GGNATLQVD+WPVNE YP GRQ
Sbjct: 144 EQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGRQ 203
Query: 1216 LTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLKVLALAAESDPNVRTEGHLRLVGEGPS 1275
LTIFN+QA I IGG+D+GR FQGQ+SGLYY+GLKVL +AAE++PN++ G +RLVGE PS
Sbjct: 204 LTIFNTQAQIAIGGKDKGRLFQGQLSGLYYDGLKVLNMAAENNPNIKINGSVRLVGEVPS 263
Query: 1276 VLLSAETTATTLLADMATTIMETTTTMATTTTRRGRSPTLRDSTTQNTDDLLVASAECPS 1335
+L + +T T++ +M+TT+METTTTMATTTTR+ RS ++ Q T D LV+SAEC S
Sbjct: 264 ILGTTQT--TSMPPEMSTTVMETTTTMATTTTRKNRS----TASIQPTSDDLVSSAECSS 317
Query: 1336 DDEDLEECEPSTG 1348
DDED ECEPSTG
Sbjct: 318 DDEDFVECEPSTG 330
Score = 155 bits (392), Expect = 3e-37
Identities = 80/102 (78%), Positives = 90/102 (88%), Gaps = 1/102 (0%)
Query: 1541 TANPTGPGERGPPGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQV 1600
+ANPT PG R PGA EVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQV
Sbjct: 332 SANPTEPGIRRVPGASEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQV 391
Query: 1601 DQSRNYISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV 1642
D++RNYISNSAQSNG ++KEK ++ K+ K +KNKD+EYYV
Sbjct: 392 DETRNYISNSAQSNGTLMKEKQQSS-KSGHKKQKNKDREYYV 432
Score = 50.4 bits (119), Expect = 1e-05
Identities = 36/106 (33%), Positives = 58/106 (54%), Gaps = 7/106 (6%)
Query: 906 FKTTAPDGLLL-FNSGNG-NDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHN 963
F TT DG+L+ +S G DF+ + + +G I VF++G +K PVND ++H
Sbjct: 117 FSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIK-EERTPVNDGKYHV 175
Query: 964 VVVSRDPGNVHTLKIDSRTVTQHSNGARNLDL---KGELYIGGLSK 1006
V +R+ GN TL++D+ V +H R L + + ++ IGG K
Sbjct: 176 VRFTRNGGNA-TLQVDNWPVNEHYPTGRQLTIFNTQAQIAIGGKDK 220
Score = 41.6 bits (96), Expect = 0.006
Identities = 37/169 (21%), Positives = 69/169 (40%), Gaps = 27/169 (15%)
Query: 287 TDEITLAFRTLQRNGLMLHTGKS---ADYVNLSLKSGAVWLVINLGSGAFEALVEPVNGK 343
+D + + F T ++G+++ + D++ L ++ G + +V N+G+ + ++
Sbjct: 110 SDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGT--VDISIKEERTP 167
Query: 344 FNDNAWHDVRVTRNLRQHAGIGHAMVTISVDGILTTTGY-TQEDYTMLGSDDFFYIGGSP 402
ND +H VR TRN T+ VD Y T T+ + IGG
Sbjct: 168 VNDGKYHVVRFTRN--------GGNATLQVDNWPVNEHYPTGRQLTIFNTQAQIAIGGKD 219
Query: 403 NTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEGDPKMKLQGDL 451
F G L + Y L++ +A E +P +K+ G +
Sbjct: 220 K---------GRLFQGQLSGLYYDG----LKVLNMAAENNPNIKINGSV 255
Score = 39.3 bits (90), Expect = 0.032
Identities = 23/81 (28%), Positives = 40/81 (49%), Gaps = 1/81 (1%)
Query: 50 SGELSFSLRTNATRALLLYLDDG-GDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVA 108
S L+ T +L+ +D G DFL+L + G++ + F + + + + TPV
Sbjct: 110 SDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVN 169
Query: 109 DDRWHMVLLTRDARRTALAVD 129
D ++H+V TR+ L VD
Sbjct: 170 DGKYHVVRFTRNGGNATLQVD 190
Score = 35.4 bits (80), Expect = 0.46
Identities = 33/146 (22%), Positives = 63/146 (43%), Gaps = 12/146 (8%)
Query: 720 TEAEDVSLRFMSQRAYGLMMATTSRES-ADTLRLELDGGQMKLTVNLGKGPETLFAGHK- 777
T ++ +++ F + G+++ S D L+L ++ G++ + N+G ++
Sbjct: 108 TRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTP 167
Query: 778 LNDNEWHTVRVVRRGKSLQLSVDNVTVEGQMAGAHMRLEFH---NIETGIMTERRFISVV 834
+ND ++H VR R G + L VDN V F+ I G + R
Sbjct: 168 VNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGRQLTIFNTQAQIAIGGKDKGRL---- 223
Query: 835 PSNFIGHLSGLVFNGQPYMDQCKDGD 860
F G LSGL ++G ++ + +
Sbjct: 224 ---FQGQLSGLYYDGLKVLNMAAENN 246
Score = 35.0 bits (79), Expect = 0.60
Identities = 27/124 (21%), Positives = 58/124 (46%), Gaps = 13/124 (10%)
Query: 482 RTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSG 541
R+ +++ F TT +G+L+ S+ D+ + + G + ++ ++G+
Sbjct: 109 RSDRLAVGFSTTVKDGILVRID-----------SAPGLGDFLQLHIEQGKIGVVFNIGTV 157
Query: 542 GIKLRASSRKVNDGEWCHVDFQRDGRKGSISV-NSRSTPFLATG-DSEILDLESELYLGG 599
I ++ VNDG++ V F R+G ++ V N TG I + ++++ +GG
Sbjct: 158 DISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGRQLTIFNTQAQIAIGG 217
Query: 600 LPEG 603
+G
Sbjct: 218 KDKG 221
>gi|157427673 neurexin 3 isoform 3 precursor [Homo sapiens]
Length = 459
Score = 328 bits (842), Expect = 2e-89
Identities = 170/282 (60%), Positives = 205/282 (72%), Gaps = 36/282 (12%)
Query: 1096 GTTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHI 1155
G TYIFGK G LI YTWP NDRPSTR DRLAVGFST + +LVR+DSA GLGD+LQLHI
Sbjct: 84 GATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHI 143
Query: 1156 DQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPA--- 1212
+QG +GV+FN+GT DI+I E V+DGKYHVVRFTR+GGNATLQVD+WPVNE YP
Sbjct: 144 EQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGNT 203
Query: 1213 ---------------------------GRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYY 1245
GRQLTIFN+QA I IGG+D+GR FQGQ+SGLYY
Sbjct: 204 DNERFQMVKQKIPFKYNRPVEEWLQEKGRQLTIFNTQAQIAIGGKDKGRLFQGQLSGLYY 263
Query: 1246 NGLKVLALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATT 1305
+GLKVL +AAE++PN++ G +RLVGE PS+L + +T T++ +M+TT+METTTTMATT
Sbjct: 264 DGLKVLNMAAENNPNIKINGSVRLVGEVPSILGTTQT--TSMPPEMSTTVMETTTTMATT 321
Query: 1306 TTRRGRSPTLRDSTTQNTDDLLVASAECPSDDEDLEECEPST 1347
TTR+ RS ++ Q T D LV+SAEC SDDED ECEPST
Sbjct: 322 TTRKNRS----TASIQPTSDDLVSSAECSSDDEDFVECEPST 359
Score = 157 bits (396), Expect = 1e-37
Identities = 81/102 (79%), Positives = 90/102 (88%), Gaps = 1/102 (0%)
Query: 1541 TANPTGPGERGPPGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQV 1600
TANPT PG R PGA EVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQV
Sbjct: 359 TANPTEPGIRRVPGASEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQV 418
Query: 1601 DQSRNYISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV 1642
D++RNYISNSAQSNG ++KEK ++ K+ K +KNKD+EYYV
Sbjct: 419 DETRNYISNSAQSNGTLMKEKQQSS-KSGHKKQKNKDREYYV 459
Score = 45.8 bits (107), Expect = 3e-04
Identities = 30/83 (36%), Positives = 48/83 (57%), Gaps = 4/83 (4%)
Query: 906 FKTTAPDGLLL-FNSGNG-NDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHN 963
F TT DG+L+ +S G DF+ + + +G I VF++G +K PVND ++H
Sbjct: 117 FSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIK-EERTPVNDGKYHV 175
Query: 964 VVVSRDPGNVHTLKIDSRTVTQH 986
V +R+ GN TL++D+ V +H
Sbjct: 176 VRFTRNGGNA-TLQVDNWPVNEH 197
Score = 39.3 bits (90), Expect = 0.032
Identities = 23/81 (28%), Positives = 40/81 (49%), Gaps = 1/81 (1%)
Query: 50 SGELSFSLRTNATRALLLYLDDG-GDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVA 108
S L+ T +L+ +D G DFL+L + G++ + F + + + + TPV
Sbjct: 110 SDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVN 169
Query: 109 DDRWHMVLLTRDARRTALAVD 129
D ++H+V TR+ L VD
Sbjct: 170 DGKYHVVRFTRNGGNATLQVD 190
Score = 36.2 bits (82), Expect = 0.27
Identities = 18/74 (24%), Positives = 39/74 (52%), Gaps = 5/74 (6%)
Query: 287 TDEITLAFRTLQRNGLMLHTGKS---ADYVNLSLKSGAVWLVINLGSGAFEALVEPVNGK 343
+D + + F T ++G+++ + D++ L ++ G + +V N+G+ + ++
Sbjct: 110 SDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGT--VDISIKEERTP 167
Query: 344 FNDNAWHDVRVTRN 357
ND +H VR TRN
Sbjct: 168 VNDGKYHVVRFTRN 181
Score = 33.5 bits (75), Expect = 1.7
Identities = 20/94 (21%), Positives = 46/94 (48%), Gaps = 11/94 (11%)
Query: 482 RTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSG 541
R+ +++ F TT +G+L+ S+ D+ + + G + ++ ++G+
Sbjct: 109 RSDRLAVGFSTTVKDGILVRID-----------SAPGLGDFLQLHIEQGKIGVVFNIGTV 157
Query: 542 GIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNS 575
I ++ VNDG++ V F R+G ++ V++
Sbjct: 158 DISIKEERTPVNDGKYHVVRFTRNGGNATLQVDN 191
Score = 33.1 bits (74), Expect = 2.3
Identities = 21/84 (25%), Positives = 43/84 (51%), Gaps = 2/84 (2%)
Query: 720 TEAEDVSLRFMSQRAYGLMMATTSRES-ADTLRLELDGGQMKLTVNLGKGPETLFAGHK- 777
T ++ +++ F + G+++ S D L+L ++ G++ + N+G ++
Sbjct: 108 TRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTP 167
Query: 778 LNDNEWHTVRVVRRGKSLQLSVDN 801
+ND ++H VR R G + L VDN
Sbjct: 168 VNDGKYHVVRFTRNGGNATLQVDN 191
>gi|54873613 agrin [Homo sapiens]
Length = 2045
Score = 162 bits (410), Expect = 2e-39
Identities = 187/660 (28%), Positives = 275/660 (41%), Gaps = 113/660 (17%)
Query: 53 LSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDRW 112
L+ R + LLLY + DFL L L+DGR++LRF PA L PV +W
Sbjct: 1396 LALEFRALEPQGLLLYNGNARGKDFLALALLDGRVQLRFDTGSG-PAVLTSAVPVEPGQW 1454
Query: 113 HMVLLTRDARRTALAVDGEARA-AEVRSKRREMQVASDLFVGGIPPDVRLSALTLSTVKY 171
H + L+R RR L+VDGE E S + + +DLFVGG+P D +A+ L
Sbjct: 1455 HRLELSRHWRRGTLSVDGETPVLGESPSGTDGLNLDTDLFVGGVPED--QAAVALERTFV 1512
Query: 172 EPPFRGLL-------ANLKLGERPPALLGSQGLRGATADPLCAPARNPCANGGLCTVLAP 224
RG + L+LG P A G+ G D C P NPC G C L
Sbjct: 1513 GAGLRGCIRLLDVNNQRLELGIGPGAATRGSGV-GECGDHPCLP--NPCHGGAPCQNLEA 1569
Query: 225 GEVGCDCSHTGFGGKFCSEEEHPME-GPAH---------------------------LTL 256
G C C G G C++E+ P + P H
Sbjct: 1570 GRFHCQCP-PGRVGPTCADEKSPCQPNPCHGAAPCRVLPEGGAQCECPLGREGTFCQTAS 1628
Query: 257 NSEGKEEFVATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQR--NGLMLHTGK----SA 310
+G F+A F G H + +++ L L R +GL+L+ G+
Sbjct: 1629 GQDGSGPFLADFNGFSHLELRGLHTFARDLGEKMALEVVFLARGPSGLLLYNGQKTDGKG 1688
Query: 311 DYVNLSLKSGAVWLVINLGSGAFEALV---EPVNGKFNDNAWHDVRVTRNLRQHAGIGHA 367
D+V+L+L+ + +LG GA A++ EPV AW V + RN R+ A
Sbjct: 1689 DFVSLALRDRRLEFRYDLGKGA--AVIRSREPV----TLGAWTRVSLERNGRKGA----- 1737
Query: 368 MVTISVDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADLP-GSPVSNNFMGCLKDVVYK 426
+ V G + +T+L + Y+GG+P+ + L + VS+ F G ++ V
Sbjct: 1738 ---LRVGDGPRVLGESPVPHTVLNLKEPLYVGGAPDFSKLARAAAVSSGFDGAIQLVSLG 1794
Query: 427 NNDF--------KLELSRLAKEGDPKMKLQGDLSF-------RCEDVAALDPVTFESPEA 471
+++++ A G P + G R L P F P
Sbjct: 1795 GRQLLTPEHVLRQVDVTSFA--GHPCTRASGHPCLNGASCVPREAAYVCLCPGGFSGPHC 1852
Query: 472 FVALPRWSAKRTGSISLDFRT--------TEPNGLLL---FSQGRRAGGGAG----SHSS 516
L SA +++ D RT TE L F R G S +
Sbjct: 1853 EKGLVEKSAGDVDTLAFDGRTFVEYLNAVTESEKALQSNHFELSLRTEATQGLVLWSGKA 1912
Query: 517 AQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNSR 576
+RADY A+ ++DGHL L ++GS + LR S+ VN W V R+ R+GS+ V +
Sbjct: 1913 TERADYVALAIVDGHLQLSYNLGSQPVVLR-STVPVNTNRWLRVVAHREQREGSLQVGNE 1971
Query: 577 STPFLATGDSEI----LDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFI 632
+ TG S + LD + L+LGGLPE LP+ P + A G+VGC+RD+ +
Sbjct: 1972 AP---VTGSSPLGATQLDTDGALWLGGLPE-----LPVGPAL-PKAYGTGFVGCLRDVVV 2022
Score = 125 bits (315), Expect = 3e-28
Identities = 174/703 (24%), Positives = 283/703 (40%), Gaps = 148/703 (21%)
Query: 455 CEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSH 514
CE V FE +F+A P A T ++L+FR EP GLLL+ +
Sbjct: 1366 CEKVLGAPVPAFEG-RSFLAFPTLRAYHTLRLALEFRALEPQGLLLY------------N 1412
Query: 515 SSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVN 574
+A+ D+ A+ LLDG + L D GSG L S+ V G+W ++ R R+G++SV+
Sbjct: 1413 GNARGKDFLALALLDGRVQLRFDTGSGPAVL-TSAVPVEPGQWHRLELSRHWRRGTLSVD 1471
Query: 575 SRSTPFLATGDS--EILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFI 632
TP L S + L+L+++L++GG+PE + + L A LR GC+R L +
Sbjct: 1472 G-ETPVLGESPSGTDGLNLDTDLFVGGVPE-DQAAVALERTFVGAGLR----GCIRLLDV 1525
Query: 633 DGRSRDL---RGLAEAQGAVG----------------------------------VAPFC 655
+ + +L G A VG V P C
Sbjct: 1526 NNQRLELGIGPGAATRGSGVGECGDHPCLPNPCHGGAPCQNLEAGRFHCQCPPGRVGPTC 1585
Query: 656 SRETLKQCASAPCRNGGVCR---EGWNRFICDCIGTGFLGRVCEREA-------TVLSYD 705
+ E C PC CR EG + C+C G G C+ + + ++
Sbjct: 1586 ADEK-SPCQPNPCHGAAPCRVLPEGGAQ--CEC-PLGREGTFCQTASGQDGSGPFLADFN 1641
Query: 706 GSMYMKIMLPNAMHTEAEDVSLR------FMSQRAYGLMMATTSRE--SADTLRLELDGG 757
G ++++ +HT A D+ + F+++ GL++ + D + L L
Sbjct: 1642 GFSHLEL---RGLHTFARDLGEKMALEVVFLARGPSGLLLYNGQKTDGKGDFVSLALRDR 1698
Query: 758 QMKLTVNLGKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSV-DNVTVEGQMAGAHMRLE 816
+++ +LGKG + + + W V + R G+ L V D V G+ H L
Sbjct: 1699 RLEFRYDLGKGAAVIRSREPVTLGAWTRVSLERNGRKGALRVGDGPRVLGESPVPHTVLN 1758
Query: 817 FHN------------------IETGIMTERRFIS------VVPSNFIGHLSGLVFNGQP- 851
+ +G + +S + P + + + F G P
Sbjct: 1759 LKEPLYVGGAPDFSKLARAAAVSSGFDGAIQLVSLGGRQLLTPEHVLRQVDVTSFAGHPC 1818
Query: 852 --------------------YMDQCKDG-DITYCELNARFGLRAIVADPVTFKSRS--SY 888
Y+ C G +CE A D + F R+ Y
Sbjct: 1819 TRASGHPCLNGASCVPREAAYVCLCPGGFSGPHCE-KGLVEKSAGDVDTLAFDGRTFVEY 1877
Query: 889 LALAT--LQAYASMHLFFQFKTTAPDGLLLFNSGNGN---DFIVIELVKGYIHYVFDLGN 943
L T +A S H +T A GL+L+ SG D++ + +V G++ ++LG+
Sbjct: 1878 LNAVTESEKALQSNHFELSLRTEATQGLVLW-SGKATERADYVALAIVDGHLQLSYNLGS 1936
Query: 944 GPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSN--GARNLDLKGELYI 1001
P +++ S PVN N+W VV R+ +L++ + S+ GA LD G L++
Sbjct: 1937 QPVVLR--STVPVNTNRWLRVVAHREQ-REGSLQVGNEAPVTGSSPLGATQLDTDGALWL 1993
Query: 1002 GGLSK-NMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADAL 1043
GGL + + LPK A GF GCL V + L+ DA+
Sbjct: 1994 GGLPELPVGPALPK--AYGTGFVGCLRDVVVGRHPLHLLEDAV 2034
Score = 94.7 bits (234), Expect = 6e-19
Identities = 117/400 (29%), Positives = 162/400 (40%), Gaps = 48/400 (12%)
Query: 41 YARWAGAASSGELSFSLRTNATRALLLYLDD--GGDCDFLELLLVDGRLRLRFTLSCAEP 98
+AR G + E+ F R LLLY G DF+ L L D RL R+ L
Sbjct: 1654 FARDLGEKMALEVVFLAR--GPSGLLLYNGQKTDGKGDFVSLALRDRRLEFRYDLGKGA- 1710
Query: 99 ATLQLDTPVADDRWHMVLLTRDARRTALAV-DGEARAAEVRSKRREMQVASDLFVGGIPP 157
A ++ PV W V L R+ R+ AL V DG E + + L+VGG P
Sbjct: 1711 AVIRSREPVTLGAWTRVSLERNGRKGALRVGDGPRVLGESPVPHTVLNLKEPLYVGGAPD 1770
Query: 158 DVRLSALTLSTVKYEPPFRGLLANLKLGER----PPALLGSQGLRGATADPLCAPARNPC 213
+L+ F G + + LG R P +L + P + +PC
Sbjct: 1771 FSKLAR----AAAVSSGFDGAIQLVSLGGRQLLTPEHVLRQVDVTSFAGHPCTRASGHPC 1826
Query: 214 ANGGLCTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEGKEEFVATFKGNEF 273
NG C V C C GF G C + L S G + +A F G F
Sbjct: 1827 LNGASCVPREAAYV-CLCPG-GFSGPHCEKG---------LVEKSAGDVDTLA-FDGRTF 1874
Query: 274 FCY----DLSHNPIQSSTDEITLAFRTLQRNGLMLHTGKS---ADYVNLSLKSGAVWLVI 326
Y S +QS+ E++L RT GL+L +GK+ ADYV L++ G + L
Sbjct: 1875 VEYLNAVTESEKALQSNHFELSL--RTEATQGLVLWSGKATERADYVALAIVDGHLQLSY 1932
Query: 327 NLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVTISVDGILTTTGYTQED 386
NLGS + +V N N W +RV + Q G ++ V TG +
Sbjct: 1933 NLGS---QPVVLRSTVPVNTNRW--LRVVAHREQREG------SLQVGNEAPVTGSSPLG 1981
Query: 387 YTMLGSDDFFYIGGSPNTADLPGSP--VSNNFMGCLKDVV 424
T L +D ++GG P P P F+GCL+DVV
Sbjct: 1982 ATQLDTDGALWLGGLPELPVGPALPKAYGTGFVGCLRDVV 2021
Score = 89.7 bits (221), Expect = 2e-17
Identities = 75/257 (29%), Positives = 115/257 (44%), Gaps = 17/257 (6%)
Query: 847 FNGQPYMDQCKDGDITYCELNARFG---LRAIVADPVTFKSRSSYLALATLQAYASMHLF 903
F+G D G T C A G ++ PV S+LA TL+AY ++ L
Sbjct: 1339 FHGGTCQDWALGGGFT-CSCPAGRGGAVCEKVLGAPVPAFEGRSFLAFPTLRAYHTLRLA 1397
Query: 904 FQFKTTAPDGLLLFN-SGNGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWH 962
+F+ P GLLL+N + G DF+ + L+ G + FD G+GP+++ S PV QWH
Sbjct: 1398 LEFRALEPQGLLLYNGNARGKDFLALALLDGRVQLRFDTGSGPAVL--TSAVPVEPGQWH 1455
Query: 963 NVVVSRDPGNVHTLKIDSRT--VTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRD 1020
+ +SR TL +D T + + +G L+L +L++GG+ ++ + +
Sbjct: 1456 RLELSRH-WRRGTLSVDGETPVLGESPSGTDGLNLDTDLFVGGVPEDQAAVALERTFVGA 1514
Query: 1021 GFQGCLASVDLNGRLPDL-IADALHRIGQVERGC-DGPSTTCTEESCANQGVCLQQWDG- 1077
G +GC+ +D+N + +L I G C D P C C C G
Sbjct: 1515 GLRGCIRLLDVNNQRLELGIGPGAATRGSGVGECGDHP---CLPNPCHGGAPCQNLEAGR 1571
Query: 1078 FTCDCTMTSYGGPVCND 1094
F C C GP C D
Sbjct: 1572 FHCQCP-PGRVGPTCAD 1587
Score = 71.6 bits (174), Expect = 6e-12
Identities = 89/363 (24%), Positives = 145/363 (39%), Gaps = 31/363 (8%)
Query: 887 SYLALATLQAYA-----SMHLFFQFKTTAPDGLLLFNS----GNGNDFIVIELVKGYIHY 937
S+L L L +A M L F P GLLL+N G G DF+ + L + +
Sbjct: 1644 SHLELRGLHTFARDLGEKMALEVVFLARGPSGLLLYNGQKTDGKG-DFVSLALRDRRLEF 1702
Query: 938 VFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDS--RTVTQHSNGARNLDL 995
+DLG G ++++ S +PV W V + R+ G L++ R + + L+L
Sbjct: 1703 RYDLGKGAAVIR--SREPVTLGAWTRVSLERN-GRKGALRVGDGPRVLGESPVPHTVLNL 1759
Query: 996 KGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDG 1055
K LY+GG FS L + A GF G + V L GR L + + R V
Sbjct: 1760 KEPLYVGGAPD--FSKLARAAAVSSGFDGAIQLVSLGGR-QLLTPEHVLRQVDVTSFAGH 1816
Query: 1056 PSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYIFG-------KGGALI 1108
P T + C N C+ + + C C + GP C G G +
Sbjct: 1817 PCTRASGHPCLNGASCVPREAAYVCLCP-GGFSGPHCEKGLVEKSAGDVDTLAFDGRTFV 1875
Query: 1109 TY-TWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNVG 1167
Y + + + + T +++ A+ DY+ L I G + + +N+G
Sbjct: 1876 EYLNAVTESEKALQSNHFELSLRTEATQGLVLWSGKATERADYVALAIVDGHLQLSYNLG 1935
Query: 1168 TDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQV-DSWPVNERYPAGRQLTIFNSQAAIK 1226
+ + + V+ ++ V R +LQV + PV P G T ++ A+
Sbjct: 1936 SQPVVL-RSTVPVNTNRWLRVVAHREQREGSLQVGNEAPVTGSSPLG--ATQLDTDGALW 1992
Query: 1227 IGG 1229
+GG
Sbjct: 1993 LGG 1995
Score = 66.6 bits (161), Expect = 2e-10
Identities = 47/159 (29%), Positives = 74/159 (46%), Gaps = 9/159 (5%)
Query: 650 GVAPFCSRETLKQCASAPCRNGGVCREGW---NRFICDCIGTGFLGRVCERE--ATVLSY 704
G P ++ K C S PC +GG C++ W F C C G G VCE+ A V ++
Sbjct: 1320 GRRPPAPQQPPKPCDSQPCFHGGTCQD-WALGGGFTCSC-PAGRGGAVCEKVLGAPVPAF 1377
Query: 705 DGSMYMKIMLPNAMHTEAEDVSLRFMSQRAYGLMMATTSRESADTLRLELDGGQMKLTVN 764
+G ++ A HT ++L F + GL++ + D L L L G+++L +
Sbjct: 1378 EGRSFLAFPTLRAYHTLR--LALEFRALEPQGLLLYNGNARGKDFLALALLDGRVQLRFD 1435
Query: 765 LGKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDNVT 803
G GP L + + +WH + + R + LSVD T
Sbjct: 1436 TGSGPAVLTSAVPVEPGQWHRLELSRHWRRGTLSVDGET 1474
Score = 57.8 bits (138), Expect = 9e-08
Identities = 51/170 (30%), Positives = 76/170 (44%), Gaps = 17/170 (10%)
Query: 47 AASSGELSFSLRTNATRALLLYLDDGGD-CDFLELLLVDGRLRLRFTLSCAEPATLQLDT 105
A S SLRT AT+ L+L+ + D++ L +VDG L+L + L ++P L+
Sbjct: 1887 ALQSNHFELSLRTEATQGLVLWSGKATERADYVALAIVDGHLQLSYNLG-SQPVVLRSTV 1945
Query: 106 PVADDRWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASD--LFVGGIPPDVRLSA 163
PV +RW V+ R+ R +L V EA S Q+ +D L++GG+P L
Sbjct: 1946 PVNTNRWLRVVAHREQREGSLQVGNEAPVTG-SSPLGATQLDTDGALWLGGLP---ELPV 2001
Query: 164 LTLSTVKYEPPFRGLLANLKLGERPPALLGSQGLRGATADPLCAPARNPC 213
Y F G L ++ +G P LL D + P PC
Sbjct: 2002 GPALPKAYGTGFVGCLRDVVVGRHPLHLL---------EDAVTKPELRPC 2042
Score = 33.1 bits (74), Expect = 2.3
Identities = 20/60 (33%), Positives = 25/60 (41%), Gaps = 5/60 (8%)
Query: 1045 RIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFT--CDCTMTSYGGP---VCNDPGTTY 1099
RI + RG G C+ +C+ C + DG T C C T G P VC G Y
Sbjct: 233 RIRLLSRGPCGSRDPCSNVTCSFGSTCARSADGLTASCLCPATCRGAPEGTVCGSDGADY 292
>gi|47519929 cell recognition molecule CASPR3 [Homo sapiens]
Length = 1288
Score = 139 bits (350), Expect = 2e-32
Identities = 121/447 (27%), Positives = 192/447 (42%), Gaps = 62/447 (13%)
Query: 265 VATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHT-GKSADYVNLSLKSGAVW 323
V F G Y L P++ D I+L F+ +Q NG++LH G+ +++ L L G +
Sbjct: 183 VVYFDGQSALLYRLDKKPLKPIRDVISLKFKAMQSNGILLHREGQHGNHITLELIKGKLV 242
Query: 324 LVINLGSGAFEALVEPVN----GKFNDNAWHDVRVTRNLRQHAGIGHAMVTISVDGILTT 379
+N G+ + + PV +D WH V + + V +VD T
Sbjct: 243 FFLNSGNAKLPSTIAPVTLTLGSLLDDQHWHSVLIE--------LLDTQVNFTVDKH-TH 293
Query: 380 TGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVS---NNFMGCLKDVVYKNNDFKLELSR 436
+ D + L + GG P PG + +F GCL+++ Y D ++
Sbjct: 294 HFQAKGDSSYLDLNFEISFGGIPT----PGRSRAFRRKSFHGCLENLYYNGVD----VTE 345
Query: 437 LAKEGDPKMKLQGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPN 496
LAK+ P++ + G++SF C + PVTF S +++ALP S + S++ FRT
Sbjct: 346 LAKKHKPQILMMGNVSFSCPQPQTV-PVTFLSSRSYLALPGNSGEDKVSVTFQFRTWNRA 404
Query: 497 GLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGE 556
G LLF + RR G F + L DG L L L + + +NDG+
Sbjct: 405 GHLLFGELRRGSGS------------FVLFLKDGKLKLSLFQPGQSPRNVTAGAGLNDGQ 452
Query: 557 WCHVDFQRDGRKGSISVNSRST--PFLATGDSEILDLESELYLGGLPE---GGRVDLPLP 611
W V F ++ V+ + P +A ++D Y GG + G PL
Sbjct: 453 WHSVSFSAKWSHMNVVVDDDTAVQPLVAV----LIDSGDTYYFGGCLDNSSGSGCKSPL- 507
Query: 612 PEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGV---APFCSRETLKQCASAPC 668
G+ GC+R + I ++ D + QGA+G S +C + C
Sbjct: 508 ---------GGFQGCLRLITIGDKAVD--PILVQQGALGSFRDLQIDSCGITDRCLPSYC 556
Query: 669 RNGGVCREGWNRFICDCIGTGFLGRVC 695
+GG C + W+ F CDC+GTG+ G C
Sbjct: 557 EHGGECSQSWDTFSCDCLGTGYTGETC 583
Score = 117 bits (292), Expect = 1e-25
Identities = 113/415 (27%), Positives = 172/415 (41%), Gaps = 23/415 (5%)
Query: 695 CEREATVLSYDGSMYMKIMLPNAMHTEAEDV-SLRFMSQRAYGLMMATTSRESADTLRLE 753
C ++ V+ +DG + L DV SL+F + ++ G+++ + + + LE
Sbjct: 177 CAYKSEVVYFDGQSALLYRLDKKPLKPIRDVISLKFKAMQSNGILLHREGQHG-NHITLE 235
Query: 754 LDGGQMKLTVNLGKG-------PETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDNVTVEG 806
L G++ +N G P TL G L+D WH+V + + +VD T
Sbjct: 236 LIKGKLVFFLNSGNAKLPSTIAPVTLTLGSLLDDQHWHSVLIELLDTQVNFTVDKHTHHF 295
Query: 807 QMAG--AHMRLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDGDITYC 864
Q G +++ L F GI T R + +F G L L +NG + K
Sbjct: 296 QAKGDSSYLDLNFEISFGGIPTPGRSRAFRRKSFHGCLENLYYNGVDVTELAKKHKPQIL 355
Query: 865 EL-NARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNS-GNG 922
+ N F PVTF S SYLAL + + FQF+T G LLF G
Sbjct: 356 MMGNVSFSCPQPQTVPVTFLSSRSYLALPGNSGEDKVSVTFQFRTWNRAGHLLFGELRRG 415
Query: 923 NDFIVIELVKGYIHY-VFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSR 981
+ V+ L G + +F G P + + +ND QWH+V S +++ + +D
Sbjct: 416 SGSFVLFLKDGKLKLSLFQPGQSPRNVTAGAG--LNDGQWHSVSFSAKWSHMNVV-VDDD 472
Query: 982 TVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIA- 1040
T Q +D Y GG N + K + GFQGCL + + + D I
Sbjct: 473 TAVQPLVAVL-IDSGDTYYFGGCLDNSSGSGCK--SPLGGFQGCLRLITIGDKAVDPILV 529
Query: 1041 --DALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCN 1093
AL ++ G + C C + G C Q WD F+CDC T Y G C+
Sbjct: 530 QQGALGSFRDLQIDSCGITDRCLPSYCEHGGECSQSWDTFSCDCLGTGYTGETCH 584
Score = 111 bits (278), Expect = 5e-24
Identities = 99/345 (28%), Positives = 159/345 (46%), Gaps = 43/345 (12%)
Query: 881 TFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSGNGNDFIVIEL-VKGYIHYVF 939
+F + +SYL + + F FKTT G+ + N G DFI IEL + + F
Sbjct: 796 SFNTETSYLHFPAFHGELTADVCFFFKTTVSSGVFMENLGI-TDFIRIELRAPTEVTFSF 854
Query: 940 DLGNGPSLMKGNSDKPVNDNQWHNVVVSRD--PGNVHTLKIDSRTVTQHSNGARNLDLKG 997
D+GNGP + S P NDNQWH+V R+ ++ ++ + ++G L L
Sbjct: 855 DVGNGPCEVTVQSPTPFNDNQWHHVRAERNVKGASLQVDQLPQKMQPAPADGHVRLQLNS 914
Query: 998 ELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPS 1057
+L+IGG + + GF GC+ S+ LNG DL A G VE GC G
Sbjct: 915 QLFIGGTA-----------TRQRGFLGCIRSLQLNGVALDLEERATVTPG-VEPGCAGHC 962
Query: 1058 TTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALI-----TYTW 1112
+T C N G C ++ G TCDC ++Y GP C++ + Y F G ++ YT
Sbjct: 963 ST-YGHLCRNGGRCREKRRGVTCDCAFSAYDGPFCSNEISAY-FATGSSMTYHFQEHYTL 1020
Query: 1113 PPN----------DRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHI-DQGTVG 1161
N D TR + + + F T + ++L+ V +S +YL + + + G++
Sbjct: 1021 SENSSSLVSSLHRDVTLTR-EMITLSFRTTRTPSLLLYV--SSFYEEYLSVILANNGSLQ 1077
Query: 1162 VIFNV----GTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVD 1202
+ + + D T D N ++DG+ H V+ R ++V+
Sbjct: 1078 IRYKLDRHQNPDAFTFDFKN--MADGQLHQVKINREEAVVMVEVN 1120
Score = 77.4 bits (189), Expect = 1e-13
Identities = 83/373 (22%), Positives = 152/373 (40%), Gaps = 63/373 (16%)
Query: 457 DVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSS 516
D + + +F + +++ P + + T + F+TT +G+ + + G
Sbjct: 788 DQSFWNSASFNTETSYLHFPAFHGELTADVCFFFKTTVSSGVFMENLGI----------- 836
Query: 517 AQRADYFAMEL-LDGHLYLLLDMGSGGIKLRASS-RKVNDGEWCHVDFQRDGRKGSISVN 574
D+ +EL + D+G+G ++ S ND +W HV +R+ + S+ V+
Sbjct: 837 ---TDFIRIELRAPTEVTFSFDVGNGPCEVTVQSPTPFNDNQWHHVRAERNVKGASLQVD 893
Query: 575 S---RSTPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLF 631
+ P A G L L S+L++GG TA + G++GC+R L
Sbjct: 894 QLPQKMQPAPADGHVR-LQLNSQLFIGG----------------TATRQRGFLGCIRSLQ 936
Query: 632 IDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAP--CRNGGVCREGWNRFICDCIGTG 689
++G + DL A GV P C+ C++ CRNGG CRE CDC +
Sbjct: 937 LNGVALDLEERATV--TPGVEPGCAGH----CSTYGHLCRNGGRCREKRRGVTCDCAFSA 990
Query: 690 FLGRVCEREATVLSYDGSMYM------------KIMLPNAMHTEA----EDVSLRFMSQR 733
+ G C E + GS L +++H + E ++L F + R
Sbjct: 991 YDGPFCSNEISAYFATGSSMTYHFQEHYTLSENSSSLVSSLHRDVTLTREMITLSFRTTR 1050
Query: 734 AYGLMMATTS--RESADTLRLELDGGQMKLTVNLGKGPETL-FAGHKLNDNEWHTVRVVR 790
L++ +S E + Q++ ++ + P+ F + D + H V++ R
Sbjct: 1051 TPSLLLYVSSFYEEYLSVILANNGSLQIRYKLDRHQNPDAFTFDFKNMADGQLHQVKINR 1110
Query: 791 RGKSLQLSVDNVT 803
+ + V+ T
Sbjct: 1111 EEAVVMVEVNQST 1123
Score = 57.4 bits (137), Expect = 1e-07
Identities = 58/218 (26%), Positives = 86/218 (39%), Gaps = 36/218 (16%)
Query: 100 TLQLDTPVADDRWHMVLLTRDARRTALAVD--GEARAAEVRSKRREMQVASDLFVGGIPP 157
T+Q TP D++WH V R+ + +L VD + +Q+ S LF+GG
Sbjct: 864 TVQSPTPFNDNQWHHVRAERNVKGASLQVDQLPQKMQPAPADGHVRLQLNSQLFIGG--- 920
Query: 158 DVRLSALTLSTVKYEPPFRGLLANLKLG-------ERPPALLGSQ-GLRGATADPLCAPA 209
T + F G + +L+L ER G + G G C+
Sbjct: 921 ----------TATRQRGFLGCIRSLQLNGVALDLEERATVTPGVEPGCAGH-----CSTY 965
Query: 210 RNPCANGGLCTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEGKEEFVA--T 267
+ C NGG C G V CDC+ + + G FCS E A+ S F T
Sbjct: 966 GHLCRNGGRCREKRRG-VTCDCAFSAYDGPFCSNEI-----SAYFATGSSMTYHFQEHYT 1019
Query: 268 FKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLH 305
N H + + + ITL+FRT + L+L+
Sbjct: 1020 LSENSSSLVSSLHRDVTLTREMITLSFRTTRTPSLLLY 1057
Score = 49.7 bits (117), Expect = 2e-05
Identities = 91/383 (23%), Positives = 146/383 (38%), Gaps = 75/383 (19%)
Query: 717 AMHTE-AEDVSLRFMSQRAYGLMMATTSRESADTLRLELDGG-QMKLTVNLGKGP--ETL 772
A H E DV F + + G+ M D +R+EL ++ + ++G GP T+
Sbjct: 808 AFHGELTADVCFFFKTTVSSGVFMENLG--ITDFIRIELRAPTEVTFSFDVGNGPCEVTV 865
Query: 773 FAGHKLNDNEWHTVRVVRRGKSLQLSVDNVTVEGQMAGA--HMRLEFHN--IETGIMTER 828
+ NDN+WH VR R K L VD + + Q A A H+RL+ ++ G T +
Sbjct: 866 QSPTPFNDNQWHHVRAERNVKGASLQVDQLPQKMQPAPADGHVRLQLNSQLFIGGTATRQ 925
Query: 829 RFISVVPSNFIGHLSGLVFNG-----------QPYMDQ-CKDGDITYCEL-----NARFG 871
R F+G + L NG P ++ C TY L R
Sbjct: 926 R-------GFLGCIRSLQLNGVALDLEERATVTPGVEPGCAGHCSTYGHLCRNGGRCREK 978
Query: 872 LRAIVAD--------PVTFKSRSSYLALATLQAY----------------ASMH------ 901
R + D P S+Y A + Y +S+H
Sbjct: 979 RRGVTCDCAFSAYDGPFCSNEISAYFATGSSMTYHFQEHYTLSENSSSLVSSLHRDVTLT 1038
Query: 902 ---LFFQFKTTAPDGLLLFNSGNGNDFIVIELVKG---YIHYVFDLGNGPSLMKGNSDKP 955
+ F+TT LLL+ S +++ + L I Y D P + K
Sbjct: 1039 REMITLSFRTTRTPSLLLYVSSFYEEYLSVILANNGSLQIRYKLDRHQNPDAFTFDF-KN 1097
Query: 956 VNDNQWHNVVVSRDPGNVHTLKIDSRTVTQ--HSNGARNLDLKGELYIGGLSKNMFSNLP 1013
+ D Q H V ++R+ V ++++ T Q S+G +K L +G + + ++
Sbjct: 1098 MADGQLHQVKINREEA-VVMVEVNQSTKKQVILSSGTEFNAVK-SLILGKVLEAAGADPD 1155
Query: 1014 KLVASRDGFQGCLASVDLNGRLP 1036
A+ GF GCL++V P
Sbjct: 1156 TRRAATSGFTGCLSAVRFGRAAP 1178
Score = 40.0 bits (92), Expect = 0.019
Identities = 21/74 (28%), Positives = 38/74 (51%), Gaps = 2/74 (2%)
Query: 287 TDEITLAFRTLQRNGLMLHTGKSADYVNLSLKSGA-VWLVINLGSGAFEALVEPVNGKFN 345
T ++ F+T +G+ + D++ + L++ V ++G+G E V+ FN
Sbjct: 814 TADVCFFFKTTVSSGVFMENLGITDFIRIELRAPTEVTFSFDVGNGPCEVTVQSPT-PFN 872
Query: 346 DNAWHDVRVTRNLR 359
DN WH VR RN++
Sbjct: 873 DNQWHHVRAERNVK 886
Score = 38.9 bits (89), Expect = 0.041
Identities = 45/175 (25%), Positives = 73/175 (41%), Gaps = 21/175 (12%)
Query: 53 LSFSLRTNATRALLLYLDDGGDCDFLELLLVD-GRLRLRFTLSCAE-PATLQLDTP-VAD 109
++ S RT T +LLLY+ + ++L ++L + G L++R+ L + P D +AD
Sbjct: 1042 ITLSFRTTRTPSLLLYVSSFYE-EYLSVILANNGSLQIRYKLDRHQNPDAFTFDFKNMAD 1100
Query: 110 DRWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVG------GIPPDVRLSA 163
+ H V + R+ + V+ + + S E L +G G PD R +A
Sbjct: 1101 GQLHQVKINREEAVVMVEVNQSTKKQVILSSGTEFNAVKSLILGKVLEAAGADPDTRRAA 1160
Query: 164 LTLSTVKYEPPFRGLLANLKLGERPP--ALLGSQGLRGATADPLCAPARNPCANG 216
+ F G L+ ++ G P A L G T AP CA G
Sbjct: 1161 TS--------GFTGCLSAVRFGRAAPLKAALRPSGPSRVTVRGHVAPMAR-CAAG 1206
Score = 36.2 bits (82), Expect = 0.27
Identities = 34/109 (31%), Positives = 53/109 (48%), Gaps = 9/109 (8%)
Query: 1146 GLGDYLQLHIDQGT-VGVIFNVGTD--DITIDEPNAIVSDGKYHVVRFTRSGGNATLQVD 1202
G+ D++++ + T V F+VG ++T+ P +D ++H VR R+ A+LQVD
Sbjct: 835 GITDFIRIELRAPTEVTFSFDVGNGPCEVTVQSPTPF-NDNQWHHVRAERNVKGASLQVD 893
Query: 1203 SWPVNERYPA---GRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGL 1248
P + PA G NSQ I G + R F G + L NG+
Sbjct: 894 QLP-QKMQPAPADGHVRLQLNSQLFIG-GTATRQRGFLGCIRSLQLNGV 940
Score = 35.0 bits (79), Expect = 0.60
Identities = 48/219 (21%), Positives = 80/219 (36%), Gaps = 23/219 (10%)
Query: 49 SSGE----LSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLD 104
+SGE ++F RT LL+ + L L DG+L+L P +
Sbjct: 386 NSGEDKVSVTFQFRTWNRAGHLLFGELRRGSGSFVLFLKDGKLKLSLFQPGQSPRNVTAG 445
Query: 105 TPVADDRWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDVRLSAL 164
+ D +WH V + + VD + + + + + GG + S
Sbjct: 446 AGLNDGQWHSVSFSAKWSHMNVVVDDDTAVQPLVAVL--IDSGDTYYFGGCLDNSSGSGC 503
Query: 165 TLSTVKYEPPFRGLLANLKLGERP-PALLGSQGLRGATAD---------PLCAPARNPCA 214
F+G L + +G++ +L QG G+ D C P+ C
Sbjct: 504 KSPL----GGFQGCLRLITIGDKAVDPILVQQGALGSFRDLQIDSCGITDRCLPSY--CE 557
Query: 215 NGGLCTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAH 253
+GG C+ + CDC TG+ G+ C + AH
Sbjct: 558 HGGECS-QSWDTFSCDCLGTGYTGETCHSSLYEQSCEAH 595
Score = 33.1 bits (74), Expect = 2.3
Identities = 27/105 (25%), Positives = 41/105 (39%), Gaps = 9/105 (8%)
Query: 78 LELLLVDGRLRLRFTLSCAEPATLQLDTPVADDRWHMVLLTRDARRTALAVDGEARAAEV 137
L L G +L T++ P TL L + + D WH VL+ + VD +
Sbjct: 241 LVFFLNSGNAKLPSTIA---PVTLTLGSLLDDQHWHSVLIELLDTQVNFTVDKHTHHFQA 297
Query: 138 RSKRREMQVASDLFVGGIPPDVRLSALTLSTVKYEPPFRGLLANL 182
+ + + ++ GGIP R A + F G L NL
Sbjct: 298 KGDSSYLDLNFEISFGGIPTPGRSRAFRRKS------FHGCLENL 336
>gi|116284404 cell recognition protein CASPR4 isoform 1 [Homo
sapiens]
Length = 1308
Score = 138 bits (348), Expect = 4e-32
Identities = 119/445 (26%), Positives = 191/445 (42%), Gaps = 56/445 (12%)
Query: 265 VATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHT-GKSADYVNLSLKSGAVW 323
V G Y + D I+L F+T+Q +G++LH G + D++ L L+ ++
Sbjct: 183 VVDLDGKSSLLYRFDQKSLSPIKDIISLKFKTMQSDGILLHREGPNGDHITLQLRRARLF 242
Query: 324 LVINLGSGAFEALVEPVN----GKFNDNAWHDVRVTRNLRQHAGIGHAMVTISVDGILTT 379
L+IN G + VN +D WH V + R +Q V +VD
Sbjct: 243 LLINSGEAKLPSTSTLVNLTLGSLLDDQHWHSVLIQRLGKQ--------VNFTVDEHRHH 294
Query: 380 TGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVS---NNFMGCLKDVVYKNNDFKLELSR 436
+ + ++ ++ D GG P PG VS NF GCL+++ Y D +
Sbjct: 295 F-HARGEFNLMNLDYEISFGGIP----APGKSVSFPHRNFHGCLENLYYNGVD----IID 345
Query: 437 LAKEGDPKMKLQGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPN 496
LAK+ P++ G++SF C ++ PVTF S +++ALP +S + S + FRT
Sbjct: 346 LAKQQKPQIIAMGNVSFSCSQPQSM-PVTFLSSRSYLALPDFSGEEEVSATFQFRTWNKA 404
Query: 497 GLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGE 556
GLLLFS+ + GG + L DG L L + ++NDG+
Sbjct: 405 GLLLFSELQLISGG------------ILLFLSDGKLKSNLYQPGKLPSDITAGVELNDGQ 452
Query: 557 WCHVDFQRDGRKGSISVNSRSTPFLATGDSEILDLESELYLGGLPE---GGRVDLPLPPE 613
W V S++V+ + E + Y GG P+ G + PL
Sbjct: 453 WHSVSLSAKKNHLSVAVDGQMASAAPLLGPEQIYSGGTYYFGGCPDKSFGSKCKSPL--- 509
Query: 614 VWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETL---KQCASAPCRN 670
G+ GC+R + I G+ DL ++ QG++G ++ +C C +
Sbjct: 510 -------GGFQGCMRLISISGKVVDL--ISVQQGSLGNFSDLQIDSCGISDRCLPNYCEH 560
Query: 671 GGVCREGWNRFICDCIGTGFLGRVC 695
GG C + W+ F C+C TG+ G C
Sbjct: 561 GGECSQSWSTFHCNCTNTGYRGATC 585
Score = 131 bits (330), Expect = 5e-30
Identities = 112/426 (26%), Positives = 175/426 (41%), Gaps = 41/426 (9%)
Query: 695 CEREATVLSYDGSMYMKIMLPNAMHTEAEDV-SLRFMSQRAYGLMMATTSRESADTLRLE 753
C + V+ DG + + +D+ SL+F + ++ G+++ + D + L+
Sbjct: 177 CAYRSEVVDLDGKSSLLYRFDQKSLSPIKDIISLKFKTMQSDGILLHREG-PNGDHITLQ 235
Query: 754 LDGGQMKLTVNLGKG--PET-----LFAGHKLNDNEWHTVRVVRRGKSLQLSVDNVTVEG 806
L ++ L +N G+ P T L G L+D WH+V + R GK + +VD
Sbjct: 236 LRRARLFLLINSGEAKLPSTSTLVNLTLGSLLDDQHWHSVLIQRLGKQVNFTVDEHRHHF 295
Query: 807 QMAGAH--MRLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDGDITYC 864
G M L++ GI + +S NF G L L +NG +D K
Sbjct: 296 HARGEFNLMNLDYEISFGGIPAPGKSVSFPHRNFHGCLENLYYNGVDIIDLAKQQKPQII 355
Query: 865 EL-NARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSGNGN 923
+ N F + PVTF S SYLAL + FQF+T GLLLF+
Sbjct: 356 AMGNVSFSCSQPQSMPVTFLSSRSYLALPDFSGEEEVSATFQFRTWNKAGLLLFSE---- 411
Query: 924 DFIVIELVKGYIHYVFDLGNGPSLMKGNSDKP------------VNDNQWHNVVVSRDPG 971
++L+ G I G +K N +P +ND QWH+V +S
Sbjct: 412 ----LQLISGGILLFLSDGK----LKSNLYQPGKLPSDITAGVELNDGQWHSVSLSAKKN 463
Query: 972 NVHTLKIDSRTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDL 1031
++ G + G Y GG F + K + GFQGC+ + +
Sbjct: 464 HLSVAVDGQMASAAPLLGPEQIYSGGTYYFGGCPDKSFGS--KCKSPLGGFQGCMRLISI 521
Query: 1032 NGRLPDLIA---DALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYG 1088
+G++ DLI+ +L ++ G S C C + G C Q W F C+CT T Y
Sbjct: 522 SGKVVDLISVQQGSLGNFSDLQIDSCGISDRCLPNYCEHGGECSQSWSTFHCNCTNTGYR 581
Query: 1089 GPVCND 1094
G C++
Sbjct: 582 GATCHN 587
Score = 116 bits (291), Expect = 2e-25
Identities = 99/343 (28%), Positives = 159/343 (46%), Gaps = 39/343 (11%)
Query: 881 TFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSGNGNDFIVIELVKG-YIHYVF 939
+F + +SYL T S + F FKTTA G+ L N G DFI IEL + + F
Sbjct: 796 SFDTEASYLHFPTFHGELSADVSFFFKTTASSGVFLENLGIA-DFIRIELRSPTVVTFSF 854
Query: 940 DLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDS---RTVTQHSNGARNLDLK 996
D+GNGP + S NDNQWH+V V R+ +L++D +T ++G L L
Sbjct: 855 DVGNGPFEISVQSPTHFNDNQWHHVRVERNMKEA-SLQVDQLTPKTQPAPADGHVLLQLN 913
Query: 997 GELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGP 1056
+L++GG + + GF GC+ S+ LNG DL + +V+ GC G
Sbjct: 914 SQLFVGGTATR-----------QRGFLGCIRSLQLNGMTLDL-EERAQVTPEVQPGCRGH 961
Query: 1057 STTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALI-----TYT 1111
++ + C N G C ++ GF CDCT ++Y GP C++ + Y FG G ++I Y
Sbjct: 962 CSSYGK-LCRNGGKCRERPIGFFCDCTFSAYTGPFCSNEISAY-FGSGSSVIYNFQENYL 1019
Query: 1112 WPPND-------RPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHI-DQGTVGVI 1163
N ++ R + FS + + +S +YL + I G++ +
Sbjct: 1020 LSKNSSSHAASFHGDMKLSREMIKFSFRTTRTPSLLLFVSSFYKEYLSVIIAKNGSLQIR 1079
Query: 1164 FNVG----TDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVD 1202
+ + D + D N ++DG+ H + R G +++D
Sbjct: 1080 YKLNKYQEPDVVNFDFKN--MADGQLHHIMINREEGVVFIEID 1120
Score = 103 bits (258), Expect = 1e-21
Identities = 180/819 (21%), Positives = 310/819 (37%), Gaps = 163/819 (19%)
Query: 54 SFSLRTNATRALLLY----LDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVAD 109
+F RT LLL+ L GG + L L DG+L+ P+ + + D
Sbjct: 395 TFQFRTWNKAGLLLFSELQLISGG----ILLFLSDGKLKSNLYQPGKLPSDITAGVELND 450
Query: 110 DRWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLSTV 169
+WH V L+ ++AVDG+ +A ++ + GG P D + S +
Sbjct: 451 GQWHSVSLSAKKNHLSVAVDGQMASAAPLLGPEQIYSGGTYYFGGCP-DKSFGSKCKSPL 509
Query: 170 KYEPPFRGLLANLKLGERPPALLG-SQGLRGATAD---------PLCAPARNPCANGGLC 219
F+G + + + + L+ QG G +D C P N C +GG C
Sbjct: 510 G---GFQGCMRLISISGKVVDLISVQQGSLGNFSDLQIDSCGISDRCLP--NYCEHGGEC 564
Query: 220 TVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEGKEEFVATFKGNEFFCYDLS 279
+ + C+C++TG+ G C H ++ + E + + F+ D
Sbjct: 565 SQ-SWSTFHCNCTNTGYRGATC-----------HNSIYEQSCEAYKHRGNTSGFYYIDSD 612
Query: 280 HN----PIQSSTDEITLAFRTLQRNGLMLHTGKSADYVNLSLKSGAVWLVINLGSGAFE- 334
+ P + A+ +Q NG L ++ + N +G FE
Sbjct: 613 GSGPLEPFLLYCNMTETAWTIIQHNGSDLTRVRNTNPENPY-------------AGFFEY 659
Query: 335 -ALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVTISVDGILTT--TGYTQEDYTMLG 391
A +E + N + T ++ + + DG + G T E T G
Sbjct: 660 VASMEQLQATINRAEHCEQEFTYYCKK------SRLVNKQDGTPLSWWVGRTNETQTYWG 713
Query: 392 SDDFFYIGGSPN----TADLPGSPV-SNNFMGCLKDVVYKNNDFKL-------------- 432
G SP+ T L G+ + S + C D ND L
Sbjct: 714 -------GSSPDLQKCTCGLEGNCIDSQYYCNCDADRNEWTNDTGLLAYKEHLPVTKIVI 766
Query: 433 -ELSRLAKEGDPKMK---LQGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISL 488
+ RL E K+ QGD SF + +F++ +++ P + + + +S
Sbjct: 767 TDTGRLHSEAAYKLGPLLCQGDRSF-------WNSASFDTEASYLHFPTFHGELSADVSF 819
Query: 489 DFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLL-LDMGSGGIKLRA 547
F+TT +G+ L + G AD+ +EL + D+G+G ++
Sbjct: 820 FFKTTASSGVFLENLGI--------------ADFIRIELRSPTVVTFSFDVGNGPFEISV 865
Query: 548 SS-RKVNDGEWCHVDFQRDGRKGSISVNS---RSTPFLATGDSEILDLESELYLGGLPEG 603
S ND +W HV +R+ ++ S+ V+ ++ P A G +L L S+L++GG
Sbjct: 866 QSPTHFNDNQWHHVRVERNMKEASLQVDQLTPKTQPAPADGHV-LLQLNSQLFVGG---- 920
Query: 604 GRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQC 663
TA + G++GC+R L ++G + DL AQ V P C C
Sbjct: 921 ------------TATRQRGFLGCIRSLQLNGMTLDLE--ERAQVTPEVQPGCRGH----C 962
Query: 664 ASAP--CRNGGVCREGWNRFICDCIGTGFLGRVCEREATVLSYDGSMYMKIMLPN----- 716
+S CRNGG CRE F CDC + + G C E + GS + N
Sbjct: 963 SSYGKLCRNGGKCRERPIGFFCDCTFSAYTGPFCSNEISAYFGSGSSVIYNFQENYLLSK 1022
Query: 717 -----------AMHTEAEDVSLRFMSQRAYGLMMATTS--RESADTLRLELDGGQMKLTV 763
M E + F + R L++ +S +E + + Q++ +
Sbjct: 1023 NSSSHAASFHGDMKLSREMIKFSFRTTRTPSLLLFVSSFYKEYLSVIIAKNGSLQIRYKL 1082
Query: 764 NLGKGPETL-FAGHKLNDNEWHTVRVVRRGKSLQLSVDN 801
N + P+ + F + D + H + + R + + +D+
Sbjct: 1083 NKYQEPDVVNFDFKNMADGQLHHIMINREEGVVFIEIDD 1121
Score = 71.2 bits (173), Expect = 8e-12
Identities = 95/382 (24%), Positives = 153/382 (40%), Gaps = 74/382 (19%)
Query: 724 DVSLRFMSQRAYGLMMATTSRESADTLRLELDGGQM-KLTVNLGKGPETLFAGHK--LND 780
DVS F + + G+ + AD +R+EL + + ++G GP + ND
Sbjct: 816 DVSFFFKTTASSGVFLENLG--IADFIRIELRSPTVVTFSFDVGNGPFEISVQSPTHFND 873
Query: 781 NEWHTVRVVRRGKSLQLSVDNVTVEGQMAGA--HMRLEFHN--IETGIMTERRFISVVPS 836
N+WH VRV R K L VD +T + Q A A H+ L+ ++ G T +R
Sbjct: 874 NQWHHVRVERNMKEASLQVDQLTPKTQPAPADGHVLLQLNSQLFVGGTATRQR------- 926
Query: 837 NFIGHLSGLVFNG---------------QP--------YMDQCKDG------------DI 861
F+G + L NG QP Y C++G D
Sbjct: 927 GFLGCIRSLQLNGMTLDLEERAQVTPEVQPGCRGHCSSYGKLCRNGGKCRERPIGFFCDC 986
Query: 862 TYCELNARFGLRAIVA-----DPVTFKSRSSYLALATLQAYA-SMH---------LFFQF 906
T+ F I A V + + +YL ++A S H + F F
Sbjct: 987 TFSAYTGPFCSNEISAYFGSGSSVIYNFQENYLLSKNSSSHAASFHGDMKLSREMIKFSF 1046
Query: 907 KTTAPDGLLLFNSGNGNDFIVIELVKG---YIHYVFDLGNGPSLMKGNSD-KPVNDNQWH 962
+TT LLLF S +++ + + K I Y + P ++ N D K + D Q H
Sbjct: 1047 RTTRTPSLLLFVSSFYKEYLSVIIAKNGSLQIRYKLNKYQEPDVV--NFDFKNMADGQLH 1104
Query: 963 NVVVSRDPGNVHTLKIDSRTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGF 1022
+++++R+ G V D+R H + L +G + ++ + +A GF
Sbjct: 1105 HIMINREEGVVFIEIDDNRRRQVHLSSGTEFSAVKSLVLGRILEHSDVDQDTALAGAQGF 1164
Query: 1023 QGCLASVDLNGRLPDLIADALH 1044
GCL++V L+ P + ALH
Sbjct: 1165 TGCLSAVQLSHVAP--LKAALH 1184
Score = 51.2 bits (121), Expect = 8e-06
Identities = 63/268 (23%), Positives = 108/268 (40%), Gaps = 38/268 (14%)
Query: 50 SGELSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAE---PATLQLDTP 106
S ++SF +T A+ + +L++ G DF+ + L + + F+ ++Q T
Sbjct: 814 SADVSFFFKTTASSGV--FLENLGIADFIRIELRSPTV-VTFSFDVGNGPFEISVQSPTH 870
Query: 107 VADDRWHMVLLTRDARRTALAVDGEARAAEVRSKRRE--MQVASDLFVGGIPPDVRLSAL 164
D++WH V + R+ + +L VD + +Q+ S LFVGG
Sbjct: 871 FNDNQWHHVRVERNMKEASLQVDQLTPKTQPAPADGHVLLQLNSQLFVGG---------- 920
Query: 165 TLSTVKYEPPFRGLLANLKLG-------ERPPALLGSQ-GLRGATADPLCAPARNPCANG 216
T + F G + +L+L ER Q G RG C+ C NG
Sbjct: 921 ---TATRQRGFLGCIRSLQLNGMTLDLEERAQVTPEVQPGCRGH-----CSSYGKLCRNG 972
Query: 217 GLCTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEGKEEFVATFKGNEFFCY 276
G C G CDC+ + + G FCS E G + + + ++ + +
Sbjct: 973 GKCRERPIGFF-CDCTFSAYTGPFCSNEISAYFGSGSSVIYNFQENYLLSKNSSSHAASF 1031
Query: 277 DLSHNPIQSSTDEITLAFRTLQRNGLML 304
H ++ S + I +FRT + L+L
Sbjct: 1032 ---HGDMKLSREMIKFSFRTTRTPSLLL 1056
Score = 43.1 bits (100), Expect = 0.002
Identities = 35/159 (22%), Positives = 65/159 (40%), Gaps = 18/159 (11%)
Query: 1123 DRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNVG------TDDITIDEP 1176
D +++ F T Q +L+ + +G D++ L + + + ++ N G T +
Sbjct: 206 DIISLKFKTMQSDGILLHREGPNG--DHITLQLRRARLFLLINSGEAKLPSTSTLVNLTL 263
Query: 1177 NAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGRQLTIFNSQAAIKIGGRDQG--- 1233
+++ D +H V R G VD + A + + N I GG
Sbjct: 264 GSLLDDQHWHSVLIQRLGKQVNFTVDEH--RHHFHARGEFNLMNLDYEISFGGIPAPGKS 321
Query: 1234 -----RPFQGQVSGLYYNGLKVLALAAESDPNVRTEGHL 1267
R F G + LYYNG+ ++ LA + P + G++
Sbjct: 322 VSFPHRNFHGCLENLYYNGVDIIDLAKQQKPQIIAMGNV 360
Score = 38.9 bits (89), Expect = 0.041
Identities = 95/436 (21%), Positives = 160/436 (36%), Gaps = 101/436 (23%)
Query: 7 WRPTPPPLLLLLLLALAARADGLEFGGGPGQWARYARWAGAASSGELSFSLRTNATRALL 66
W P + + + A R++ ++ G R+ + + + +S +T + +L
Sbjct: 162 WNPKGRIGMRIEVFGCAYRSEVVDLDGKSSLLYRFDQKSLSPIKDIISLKFKTMQSDGIL 221
Query: 67 LYLDDGGDCDFLELLLVDGRLRLRFTLSCAE-PAT-----LQLDTPVADDRWHMVLLTRD 120
L+ + G + D + L L RL L A+ P+T L L + + D WH VL+ R
Sbjct: 222 LHRE-GPNGDHITLQLRRARLFLLINSGEAKLPSTSTLVNLTLGSLLDDQHWHSVLIQRL 280
Query: 121 ARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLSTVKYEPPFRGLLA 180
++ VD R + M + ++ GGIP A S F G L
Sbjct: 281 GKQVNFTVDEHRHHFHARGEFNLMNLDYEISFGGIP------APGKSVSFPHRNFHGCLE 334
Query: 181 NLKLGERPPALLGSQGLRGATADPLCAPARNPCANGGLCTVLAPGEVGCDCSHTGFGGKF 240
NL G L A + P ++A G V CS
Sbjct: 335 NLY-------------YNGVDIIDL-AKQQKP-------QIIAMGNVSFSCSQPQ----- 368
Query: 241 CSEEEHPMEGPAHLTL-NSEGKEEFVATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQR 299
S + ++L L + G+EE ATF+ FRT +
Sbjct: 369 -SMPVTFLSSRSYLALPDFSGEEEVSATFQ------------------------FRTWNK 403
Query: 300 NGLMLHTGKSADYVNLSLKSGAVWLVIN---LGSGAFEALVEP----VNGKFNDNAWHDV 352
GL+L + L L SG + L ++ L S ++ P + ND WH V
Sbjct: 404 AGLLL-------FSELQLISGGILLFLSDGKLKSNLYQPGKLPSDITAGVELNDGQWHSV 456
Query: 353 RVTRNLRQHAGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDF-----FYIGGSPNTA-- 405
++ + H ++++VDG + + +LG + +Y GG P+ +
Sbjct: 457 SLSAK-KNH-------LSVAVDGQMASAA------PLLGPEQIYSGGTYYFGGCPDKSFG 502
Query: 406 DLPGSPVSNNFMGCLK 421
SP+ F GC++
Sbjct: 503 SKCKSPL-GGFQGCMR 517
>gi|7662350 cell recognition molecule Caspr2 precursor [Homo sapiens]
Length = 1331
Score = 136 bits (343), Expect = 1e-31
Identities = 104/374 (27%), Positives = 173/374 (46%), Gaps = 46/374 (12%)
Query: 881 TFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSGNGNDFIVIELVKGY-IHYVF 939
+F + SSYL +T Q S + F FKT P G+ L N G DFI +EL + + F
Sbjct: 802 SFPNPSSYLHFSTFQGETSADISFYFKTLTPWGVFLENMGK-EDFIKLELKSATEVSFSF 860
Query: 940 DLGNGPSLMKGNSDKPVNDNQWHNVVVSRD--PGNVHTLKIDSRTVTQHSNGARNLDLKG 997
D+GNGP + S P+ND+QWH V R+ ++ ++ + + G L+L
Sbjct: 861 DVGNGPVEIVVRSPTPLNDDQWHRVTAERNVKQASLQVDRLPQQIRKAPTEGHTRLELYS 920
Query: 998 ELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPS 1057
+L++GG + GF GC+ S+ +NG DL A G + GC G
Sbjct: 921 QLFVGG------------AGGQQGFLGCIRSLRMNGVTLDLEERAKVTSGFIS-GCSGHC 967
Query: 1058 TTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCN-DPGTTYIFGKGGALITYTW---- 1112
T+ +C N G CL+++ G++CDC+ T+Y G CN D G F + G + Y +
Sbjct: 968 TSYGT-NCENGGKCLERYHGYSCDCSNTAYDGTFCNKDVGA---FFEEGMWLRYNFQAPA 1023
Query: 1113 ---------------PPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHI-D 1156
N P + + FST + +L+ + S + D+L + +
Sbjct: 1024 TNARDSSSRVDNAPDQQNSHPDLAQEEIRFSFSTTKAPCILLYISSFT--TDFLAVLVKP 1081
Query: 1157 QGTVGVIFNVG--TDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGR 1214
G++ + +N+G + ID + +++G+ H V TR L++D +P +
Sbjct: 1082 TGSLQIRYNLGGTREPYNIDVDHRNMANGQPHSVNITRHEKTIFLKLDHYPSVSYHLPSS 1141
Query: 1215 QLTIFNSQAAIKIG 1228
T+FNS ++ +G
Sbjct: 1142 SDTLFNSPKSLFLG 1155
Score = 112 bits (279), Expect = 4e-24
Identities = 106/422 (25%), Positives = 188/422 (44%), Gaps = 32/422 (7%)
Query: 695 CEREATVLSYDGSMYMKIMLPNA-MHTEAEDVSLRFMSQRAYGLMMATTSRESADTLRLE 753
C A V+++DG + + N M T + ++L F + + G+++ ++ D + LE
Sbjct: 181 CSYWADVINFDGHVVLPYRFRNKKMKTLKDVIALNFKTSESEGVILHGEGQQG-DYITLE 239
Query: 754 LDGGQMKLTVNLGK-------GPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDNVTVEG 806
L ++ L++NLG G ++ G L+D+ WH+V + R+G+S+ L++D
Sbjct: 240 LKKAKLVLSLNLGSNQLGPIYGHTSVMTGSLLDDHHWHSVVIERQGRSINLTLDRSMQHF 299
Query: 807 QMAGA--HMRLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDGDITYC 864
+ G ++ L++ GI + S NF G + + +NG D + +
Sbjct: 300 RTNGEFDYLDLDYEITFGGIPFSGKPSSSSRKNFKGCMESINYNGVNITDLARRKKLEPS 359
Query: 865 EL-NARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLF-----N 918
+ N F PV F + +SYL + + FQF+T P+GLL+F N
Sbjct: 360 NVGNLSFSCVEPYTVPVFFNA-TSYLEVPGRLNQDLFSVSFQFRTWNPNGLLVFSHFADN 418
Query: 919 SGNGNDFIVIELVKGYIHYVFDLGNGP-SLMKGNSDKPVNDNQWHNV-VVSRDPGNVHTL 976
GN + I+L + + ++ S + +S +ND QWH V ++++ + T+
Sbjct: 419 LGN----VEIDLTESKVGVHINITQTKMSQIDISSGSGLNDGQWHEVRFLAKENFAILTI 474
Query: 977 KIDSRTVTQHSNGARNLDLK-GELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRL 1035
D + + ++ L +K GE Y G N +N V + FQGC+ + ++ +L
Sbjct: 475 DGDEASAVRTNSP---LQVKTGEKYFFGGFLNQMNNSSHSVL-QPSFQGCMQLIQVDDQL 530
Query: 1036 PDLIADALHRIGQ---VERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVC 1092
+L A + G V C C + G C Q WD F C C T Y G C
Sbjct: 531 VNLYEVAQRKPGSFANVSIDMCAIIDRCVPNHCEHGGKCSQTWDSFKCTCDETGYSGATC 590
Query: 1093 ND 1094
++
Sbjct: 591 HN 592
Score = 107 bits (268), Expect = 7e-23
Identities = 105/448 (23%), Positives = 185/448 (41%), Gaps = 61/448 (13%)
Query: 265 VATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLH-TGKSADYVNLSLKSGAVW 323
V F G+ Y + +++ D I L F+T + G++LH G+ DY+ L LK +
Sbjct: 187 VINFDGHVVLPYRFRNKKMKTLKDVIALNFKTSESEGVILHGEGQQGDYITLELKKAKLV 246
Query: 324 LVINLGS---GAFEALVEPVNGKF-NDNAWHDVRVTRNLRQHAGIGHAMVTISVDGILTT 379
L +NLGS G + G +D+ WH V + R R + +++D +
Sbjct: 247 LSLNLGSNQLGPIYGHTSVMTGSLLDDHHWHSVVIERQGRS--------INLTLDRSMQH 298
Query: 380 TGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAK 439
T ++ L D GG P + P S NF GC++ + Y + ++ LA+
Sbjct: 299 FR-TNGEFDYLDLDYEITFGGIPFSGK-PSSSSRKNFKGCMESINYNG----VNITDLAR 352
Query: 440 EGDPKMKLQGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLL 499
+ G+LSF C + + PV F + +++ +P + S+S FRT PNGLL
Sbjct: 353 RKKLEPSNVGNLSFSCVEPYTV-PVFFNAT-SYLEVPGRLNQDLFSVSFQFRTWNPNGLL 410
Query: 500 LFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKV------- 552
+FS +FA L G++ + L G+ + + K+
Sbjct: 411 VFS-------------------HFADNL--GNVEIDLTESKVGVHINITQTKMSQIDISS 449
Query: 553 ----NDGEWCHVDFQRDGRKGSISVNSRSTPFLATGDSEILDLESELYLGGLPEGGRVDL 608
NDG+W V F ++++ + T + + + GG L
Sbjct: 450 GSGLNDGQWHEVRFLAKENFAILTIDGDEASAVRTNSPLQVKTGEKYFFGGF-------L 502
Query: 609 PLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQ-GAVGVAPFCSRETLKQCASAP 667
+ L+ + GC++ + +D + +L +A+ + G+ + +C
Sbjct: 503 NQMNNSSHSVLQPSFQGCMQLIQVDDQLVNLYEVAQRKPGSFANVSIDMCAIIDRCVPNH 562
Query: 668 CRNGGVCREGWNRFICDCIGTGFLGRVC 695
C +GG C + W+ F C C TG+ G C
Sbjct: 563 CEHGGKCSQTWDSFKCTCDETGYSGATC 590
Score = 79.7 bits (195), Expect = 2e-14
Identities = 88/391 (22%), Positives = 165/391 (42%), Gaps = 83/391 (21%)
Query: 445 MKLQGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQG 504
++ QGD ++ + +F +P +++ + + + IS F+T P G+ L + G
Sbjct: 789 LRCQGDRNY-------WNAASFPNPSSYLHFSTFQGETSADISFYFKTLTPWGVFLENMG 841
Query: 505 RRAGGGAGSHSSAQRADYFAMELLDG-HLYLLLDMGSGGIKLRASS-RKVNDGEWCHVDF 562
+ D+ +EL + D+G+G +++ S +ND +W V
Sbjct: 842 KE--------------DFIKLELKSATEVSFSFDVGNGPVEIVVRSPTPLNDDQWHRVTA 887
Query: 563 QRDGRKGSISVNS-----RSTPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTA 617
+R+ ++ S+ V+ R P T L+L S+L++GG GG+
Sbjct: 888 ERNVKQASLQVDRLPQQIRKAP---TEGHTRLELYSQLFVGGA--GGQ------------ 930
Query: 618 ALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCAS--APCRNGGVCR 675
G++GC+R L ++G + DL A+ G CS C S C NGG C
Sbjct: 931 ---QGFLGCIRSLRMNGVTLDLEERAKVTS--GFISGCSGH----CTSYGTNCENGGKCL 981
Query: 676 EGWNRFICDCIGTGFLGRVCEREATVLSYDGSMYMKIMLPNAMHTEAEDVSLR------- 728
E ++ + CDC T + G C ++ +G M+++ A T A D S R
Sbjct: 982 ERYHGYSCDCSNTAYDGTFCNKDVGAFFEEG-MWLRYNF-QAPATNARDSSSRVDNAPDQ 1039
Query: 729 ---------------FMSQRAYGLMMATTSRESADTLRLELDGGQMKLTVNLG--KGPET 771
F + +A +++ +S + L G +++ NLG + P
Sbjct: 1040 QNSHPDLAQEEIRFSFSTTKAPCILLYISSFTTDFLAVLVKPTGSLQIRYNLGGTREPYN 1099
Query: 772 LFAGHK-LNDNEWHTVRVVRRGKSLQLSVDN 801
+ H+ + + + H+V + R K++ L +D+
Sbjct: 1100 IDVDHRNMANGQPHSVNITRHEKTIFLKLDH 1130
Score = 62.4 bits (150), Expect = 4e-09
Identities = 103/469 (21%), Positives = 182/469 (38%), Gaps = 44/469 (9%)
Query: 35 PGQWARYARWAGAASSGELSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLS 94
P + ++ + G S+ ++SF +T + +L++ G DF++L L + F+
Sbjct: 806 PSSYLHFSTFQGETSA-DISFYFKTLTPWGV--FLENMGKEDFIKLELKSAT-EVSFSFD 861
Query: 95 CAE---PATLQLDTPVADDRWHMVLLTRDARRTALAVD---GEARAAEVRSKRREMQVAS 148
++ TP+ DD+WH V R+ ++ +L VD + R A R +++ S
Sbjct: 862 VGNGPVEIVVRSPTPLNDDQWHRVTAERNVKQASLQVDRLPQQIRKAPTEGHTR-LELYS 920
Query: 149 DLFVGGIPPDVRLSALTLSTVKYEPPFRGLLANLKLGERPPALLGSQGLRGATADPLCAP 208
LFVGG S R L L ER A + S + G + C
Sbjct: 921 QLFVGGAGGQQGFLGCIRS-------LRMNGVTLDLEER--AKVTSGFISGCSGH--CTS 969
Query: 209 ARNPCANGGLCTVLAPGEVGCDCSHTGFGGKFCSEEEHP-MEGPAHLTLNSEGKEEFVAT 267
C NGG C G CDCS+T + G FC+++ E L N +
Sbjct: 970 YGTNCENGGKCLERYHG-YSCDCSNTAYDGTFCNKDVGAFFEEGMWLRYNFQAPATNARD 1028
Query: 268 FKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHTGK-SADYVNLSLK-SGAVWLV 325
D ++ + +EI +F T + ++L+ + D++ + +K +G++ +
Sbjct: 1029 SSSRVDNAPDQQNSHPDLAQEEIRFSFSTTKAPCILLYISSFTTDFLAVLVKPTGSLQIR 1088
Query: 326 INLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVTISVDGILTTTGY-TQ 384
NLG ++ + + H V +TR+ + + +D + + +
Sbjct: 1089 YNLGGTREPYNIDVDHRNMANGQPHSVNITRH--------EKTIFLKLDHYPSVSYHLPS 1140
Query: 385 EDYTMLGSDDFFYIGGSPNTADLPGSPVSNN---FMGCLKDVVYKNNDFKLELSRLAKEG 441
T+ S ++G T + N F GCL V + N L+ +
Sbjct: 1141 SSDTLFNSPKSLFLGKVIETGKIDQEIHKYNTPGFTGCLSRVQF-NQIAPLKAALRQTNA 1199
Query: 442 DPKMKLQGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDF 490
+ +QG+L E P+T SP + P W S S DF
Sbjct: 1200 SAHVHIQGEL---VESNCGASPLTL-SPMSSATDP-WHLDHLDSASADF 1243
Score = 46.6 bits (109), Expect = 2e-04
Identities = 99/425 (23%), Positives = 166/425 (39%), Gaps = 71/425 (16%)
Query: 724 DVSLRFMSQRAYGLMMATTSRESADTLRLELDGG-QMKLTVNLGKGPETLFAGHK--LND 780
D+S F + +G+ + +E D ++LEL ++ + ++G GP + LND
Sbjct: 822 DISFYFKTLTPWGVFLENMGKE--DFIKLELKSATEVSFSFDVGNGPVEIVVRSPTPLND 879
Query: 781 NEWHTVRVVRRGKSLQLSVDNVTVEGQMA--GAHMRLEFHN--IETGIMTERRFISVVPS 836
++WH V R K L VD + + + A H RLE ++ G ++ F+ + S
Sbjct: 880 DQWHRVTAERNVKQASLQVDRLPQQIRKAPTEGHTRLELYSQLFVGGAGGQQGFLGCIRS 939
Query: 837 NFI---------------GHLSGLVFNGQPYMDQCKDG-------------------DIT 862
+ G +SG + Y C++G D T
Sbjct: 940 LRMNGVTLDLEERAKVTSGFISGCSGHCTSYGTNCENGGKCLERYHGYSCDCSNTAYDGT 999
Query: 863 YC--ELNARF----GLRAIVADPVT-FKSRSSYLALATLQA-----YASMHLFFQFKTTA 910
+C ++ A F LR P T + SS + A Q A + F F TT
Sbjct: 1000 FCNKDVGAFFEEGMWLRYNFQAPATNARDSSSRVDNAPDQQNSHPDLAQEEIRFSFSTTK 1059
Query: 911 PDGLLLFNSGNGNDFIVIELVK--GYIHYVFDLGNGPSLMKGNSD-KPVNDNQWHNVVVS 967
+LL+ S DF+ + LVK G + ++LG + D + + + Q H+V ++
Sbjct: 1060 APCILLYISSFTTDFLAV-LVKPTGSLQIRYNLGGTREPYNIDVDHRNMANGQPHSVNIT 1118
Query: 968 RDPGNVHTLKIDS-RTVTQH--SNGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQG 1024
R + LK+D +V+ H S+ + L++G + + + + GF G
Sbjct: 1119 RHEKTIF-LKLDHYPSVSYHLPSSSDTLFNSPKSLFLGKVIETGKIDQEIHKYNTPGFTG 1177
Query: 1025 CLASVDLNGRLPDLIA-------DALHRIGQ-VERGCDGPSTTCTEESCANQGVCLQQWD 1076
CL+ V N P A +H G+ VE C T + S A L D
Sbjct: 1178 CLSRVQFNQIAPLKAALRQTNASAHVHIQGELVESNCGASPLTLSPMSSATDPWHLDHLD 1237
Query: 1077 GFTCD 1081
+ D
Sbjct: 1238 SASAD 1242
Score = 46.2 bits (108), Expect = 3e-04
Identities = 41/201 (20%), Positives = 81/201 (40%), Gaps = 19/201 (9%)
Query: 53 LSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTP--VADD 110
+SF RT LL++ + +E+ L + ++ + ++ + + + + + + D
Sbjct: 397 VSFQFRTWNPNGLLVFSHFADNLGNVEIDLTESKVGVHINITQTKMSQIDISSGSGLNDG 456
Query: 111 RWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLSTVK 170
+WH V L +DG+ +A + +++ F GG + S+ ++
Sbjct: 457 QWHEVRFLAKENFAILTIDGDEASAVRTNSPLQVKTGEKYFFGGFLNQMNNSSHSV---- 512
Query: 171 YEPPFRGL---------LANL-KLGERPPALLGSQGLRGATADPLCAPARNPCANGGLCT 220
+P F+G L NL ++ +R P + + C P N C +GG C+
Sbjct: 513 LQPSFQGCMQLIQVDDQLVNLYEVAQRKPGSFANVSIDMCAIIDRCVP--NHCEHGGKCS 570
Query: 221 VLAPGEVGCDCSHTGFGGKFC 241
C C TG+ G C
Sbjct: 571 -QTWDSFKCTCDETGYSGATC 590
Score = 37.4 bits (85), Expect = 0.12
Identities = 26/98 (26%), Positives = 48/98 (48%), Gaps = 6/98 (6%)
Query: 1538 HLPTANPTGPGERGPPGAVEV-IRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEG 1596
HL +A+ P G A+ + +S+ G V+ +V LC L+ L +Y R +G
Sbjct: 1235 HLDSASADFPYNPGQGQAIRNGVNRNSAIIGGVIAVVIFTILCTLVFLI---RYMFRHKG 1291
Query: 1597 SYQVDQSRNYISNSAQSNGAVVKEKAPAAPKTPSKAKK 1634
+Y ++++ + SA+S A + P +T ++KK
Sbjct: 1292 TYHTNEAKG--AESAESADAAIMNNDPNFTETIDESKK 1327
Score = 35.4 bits (80), Expect = 0.46
Identities = 29/106 (27%), Positives = 48/106 (45%), Gaps = 4/106 (3%)
Query: 1146 GLGDYLQLHIDQGT-VGVIFNVGTD--DITIDEPNAIVSDGKYHVVRFTRSGGNATLQVD 1202
G D+++L + T V F+VG +I + P + +D ++H V R+ A+LQVD
Sbjct: 841 GKEDFIKLELKSATEVSFSFDVGNGPVEIVVRSPTPL-NDDQWHRVTAERNVKQASLQVD 899
Query: 1203 SWPVNERYPAGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGL 1248
P R T + + +GG + F G + L NG+
Sbjct: 900 RLPQQIRKAPTEGHTRLELYSQLFVGGAGGQQGFLGCIRSLRMNGV 945
>gi|38788416 laminin, alpha 1 precursor [Homo sapiens]
Length = 3075
Score = 135 bits (341), Expect = 2e-31
Identities = 212/1022 (20%), Positives = 399/1022 (39%), Gaps = 161/1022 (15%)
Query: 53 LSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDRW 112
L+ +++T LL YL DFL + + GR+ + L D P+ D+RW
Sbjct: 2142 LTLNVKTQEPDNLLFYLGSSTASDFLAVEMRRGRVAFLWDLGSGSTRLEFPDFPIDDNRW 2201
Query: 113 HMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASD---------LFVGGIPPDVRLSA 163
H + + R +L+V + + +K + ++ +FVGG+ ++ S
Sbjct: 2202 HSIHVARFGNIGSLSVKEMSSNQKSPTKTSKSPGTANVLDVNNSTLMFVGGLGGQIKKSP 2261
Query: 164 LTLSTVKYEPPFRGLLANLKLGERPPALLGSQGLRGATADPLCAPARNPCANGGLCTVLA 223
T F+G L L + L N G C
Sbjct: 2262 AVKVT-----HFKGCLGEAFLNGKSIGLW------------------NYIEREGKCR--- 2295
Query: 224 PGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEGKEEFVATFKGNEFFCYDLSHNPI 283
GC FG S+ E P + + +G Y + +
Sbjct: 2296 ----GC------FGS---SQNEDP-------SFHFDGSG-------------YSVVEKSL 2322
Query: 284 QSSTDEITLAFRTLQRNGLMLHTGK--SADYVNLSLKSGAVWLVINLGSGAFEALVEPVN 341
++ +I + F T NGL+L+ G + D++++ L G V ++ +LGSG L +
Sbjct: 2323 PATVTQIIMLFNTFSPNGLLLYLGSYGTKDFLSIELFRGRVKVMTDLGSGPITLLTDR-- 2380
Query: 342 GKFNDNAWHDVRVTRNLRQHAGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDF------ 395
++N+ W+ + RN +Q V +D T+ T++ T S D
Sbjct: 2381 -RYNNGTWYKIAFQRNRKQG-------VLAVIDAYNTSNKETKQGETPGASSDLNRLDKD 2432
Query: 396 -FYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEGDPKMKLQGDLSFR 454
Y+GG P + + + +F+GC+K++ + F L + S+
Sbjct: 2433 PIYVGGLPRSRVVRRGVTTKSFVGCIKNLEISRSTFDLLRN----------------SYG 2476
Query: 455 CEDVAALDPVTFES--PEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAG 512
L+P+ S ++ LP S + F TT +G++L + GG
Sbjct: 2477 VRKGCLLEPIRSVSFLKGGYIELPPKSLSPESEWLVTFATTNSSGIILAA----LGGDVE 2532
Query: 513 SHSSAQRA--DYFAMELLDGHLYLLLDMGSG-GIK---LRASSRKVNDGEWCHVDFQRDG 566
+ A +F++ L+ G++ + ++ G G G++ L A + +DG+ + R+
Sbjct: 2533 KRGDREEAHVPFFSVMLIGGNIEVHVNPGDGTGLRKALLHAPTGTCSDGQAHSISLVRNR 2592
Query: 567 RKGSISVNSRSTPFLATG---DSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGY 623
R ++ ++ + + G +S +++ S LY+GG+PEG L +R +
Sbjct: 2593 RIITVQLDENNPVEMKLGTLVESRTINV-SNLYVGGIPEGEGTSL--------LTMRRSF 2643
Query: 624 VGCVRDLFIDGRSRDLR-GLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCREGWNRFI 682
GC+++L + D + Q + R L AP F
Sbjct: 2644 HGCIKNLIFNLELLDFNSAVGHEQVDLDTCWLSERPKL-----APDAEDSKLLPEPRAFP 2698
Query: 683 CDCIGTGFLGRVCEREATVLSYDGSMYMKIMLPNAMHTEAEDVSLRFMSQRAYGLMMATT 742
C+ L V L+ + + + ++S+R + + GL+
Sbjct: 2699 EQCVVDAALEYVPGAHQFGLTQNSHFILPFNQSAVRKKLSVELSIRTFA--SSGLIYYMA 2756
Query: 743 SRESADTLRLELDGGQMKLTVNLGKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDN- 801
+ AD L+L GG++ +LGKG + L+D +WHTV+ + ++VD
Sbjct: 2757 HQNQADYAVLQLHGGRLHFMFDLGKGRTKVSHPALLSDGKWHTVKTDYVKRKGFITVDGR 2816
Query: 802 ----VTVEGQMAGAHMRLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCK 857
VTV G + F+ + R I + + + + N + +D K
Sbjct: 2817 ESPMVTVVGDGTMLDVEGLFYLGGLPSQYQARKIGNITHSIPACIGDVTVNSK-QLD--K 2873
Query: 858 DGDITYCELNARFGLRAIVADPVTFKSRSSYLALAT--LQAYASMHLFFQFKTTAPDGLL 915
D ++ +N + VA T+ S Y AL + + +++ +F+T++ +G+L
Sbjct: 2874 DSPVSAFTVNRCYA----VAQEGTYFDGSGYAALVKEGYKVQSDVNITLEFRTSSQNGVL 2929
Query: 916 LFNSGNGNDFIVIELVKGYIHYVFDLGNG----PSLMKGNSDKPVNDNQWHNVVVSRDPG 971
L S D I +ELV G + +F + NG + + + + D +WH + ++
Sbjct: 2930 LGISTAKVDAIGLELVDGKV--LFHVNNGAGRITAAYEPKTATVLCDGKWHTLQANKSKH 2987
Query: 972 NVHTLKIDSRTVTQHS--NGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASV 1029
+ TL +D V S + ++D +Y+GG + K + S+ F+GCL +
Sbjct: 2988 RI-TLIVDGNAVGAESPHTQSTSVDTNNPIYVGGYPAGV---KQKCLRSQTSFRGCLRKL 3043
Query: 1030 DL 1031
L
Sbjct: 3044 AL 3045
Score = 119 bits (297), Expect = 3e-26
Identities = 167/761 (21%), Positives = 302/761 (39%), Gaps = 138/761 (18%)
Query: 476 PRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLL 535
P+ S+ +++L+ +T EP+ LL + S+ +D+ A+E+ G + L
Sbjct: 2132 PQISSTNYNTLTLNVKTQEPDNLLFYL------------GSSTASDFLAVEMRRGRVAFL 2179
Query: 536 LDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNSRST-------PFLATGDSEI 588
D+GSG +L ++D W + R G GS+SV S+ + G + +
Sbjct: 2180 WDLGSGSTRLEFPDFPIDDNRWHSIHVARFGNIGSLSVKEMSSNQKSPTKTSKSPGTANV 2239
Query: 589 LDLESE--LYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQ 646
LD+ + +++GGL GG++ +V + GC+ + F++G+S
Sbjct: 2240 LDVNNSTLMFVGGL--GGQIKKSPAVKV------THFKGCLGEAFLNGKS---------- 2281
Query: 647 GAVGVAPFCSRETLKQCASAPCRNGGVCREGWNRFICDCIGTGFLGRVCEREATVLSYDG 706
+G+ + RE G CR C G+ + E +DG
Sbjct: 2282 --IGLWNYIERE-------------GKCR--------GCFGSS------QNEDPSFHFDG 2312
Query: 707 SMYMKIMLPNAMHTEAEDVSLRFMSQRAYGLMMATTSRESADTLRLELDGGQMKLTVNLG 766
S Y ++ ++ + + F + GL++ S + D L +EL G++K+ +LG
Sbjct: 2313 SGYS--VVEKSLPATVTQIIMLFNTFSPNGLLLYLGSYGTKDFLSIELFRGRVKVMTDLG 2370
Query: 767 KGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSV-------DNVTVEGQMAGAHM---RLE 816
GP TL + N+ W+ + R K L+V + T +G+ GA RL+
Sbjct: 2371 SGPITLLTDRRYNNGTWYKIAFQRNRKQGVLAVIDAYNTSNKETKQGETPGASSDLNRLD 2430
Query: 817 FHNIETGIMTERRFI--SVVPSNFIGHLSGLVFNGQPYMDQCKDGDITYCELNARFGLR- 873
I G + R + V +F+G + L + T+ L +G+R
Sbjct: 2431 KDPIYVGGLPRSRVVRRGVTTKSFVGCIKNLEISRS-----------TFDLLRNSYGVRK 2479
Query: 874 AIVADPVTFKS--RSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSGNGND------- 924
+ +P+ S + Y+ L F TT G++L G +
Sbjct: 2480 GCLLEPIRSVSFLKGGYIELPPKSLSPESEWLVTFATTNSSGIILAALGGDVEKRGDREE 2539
Query: 925 ----FIVIELVKGYIHYVFDLGNGPSLMKGNSDKPV---NDNQWHNVVVSRDPGNVHTLK 977
F + L+ G I + G+G L K P +D Q H++ + R+ + T++
Sbjct: 2540 AHVPFFSVMLIGGNIEVHVNPGDGTGLRKALLHAPTGTCSDGQAHSISLVRN-RRIITVQ 2598
Query: 978 IDSRTVTQHSNG----ARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNG 1033
+D + G +R +++ LY+GG+ + ++ L+ R F GC+ ++ N
Sbjct: 2599 LDENNPVEMKLGTLVESRTINV-SNLYVGGIPEGEGTS---LLTMRRSFHGCIKNLIFNL 2654
Query: 1034 RLPDLIADALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCN 1093
L D + H QV+ S A L + F C +
Sbjct: 2655 ELLDFNSAVGHE--QVDLDTCWLSERPKLAPDAEDSKLLPEPRAFPEQCVV--------- 2703
Query: 1094 DPGTTYIFGKGGALIT----YTWPPNDRPSTRMDRLAVGFSTHQ-RSAVLVRVDSASGLG 1148
D Y+ G +T + P N S +L+V S S+ L+ +
Sbjct: 2704 DAALEYVPGAHQFGLTQNSHFILPFNQ--SAVRKKLSVELSIRTFASSGLIYYMAHQNQA 2761
Query: 1149 DYLQLHIDQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVR 1189
DY L + G + +F++G + P A++SDGK+H V+
Sbjct: 2762 DYAVLQLHGGRLHFMFDLGKGRTKVSHP-ALLSDGKWHTVK 2801
Score = 115 bits (288), Expect = 3e-25
Identities = 226/1039 (21%), Positives = 386/1039 (37%), Gaps = 227/1039 (21%)
Query: 279 SHNPIQSSTD--EITLAFRTLQRNGLMLHTGKS--ADYVNLSLKSGAVWLVINLGSGAFE 334
++ P SST+ +TL +T + + L+ + G S +D++ + ++ G V + +LGSG+
Sbjct: 2129 AYQPQISSTNYNTLTLNVKTQEPDNLLFYLGSSTASDFLAVEMRRGRVAFLWDLGSGSTR 2188
Query: 335 ALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVTISVDGILTTTGYTQEDYTM----L 390
+E + +DN WH + V R IG V + T ++ T +
Sbjct: 2189 --LEFPDFPIDDNRWHSIHVAR----FGNIGSLSVKEMSSNQKSPTKTSKSPGTANVLDV 2242
Query: 391 GSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEGDPKMKLQGD 450
+ ++GG + +F GCL + L + + +EG K +G
Sbjct: 2243 NNSTLMFVGGLGGQIKKSPAVKVTHFKGCLGEAFLNGKSIGL-WNYIEREG----KCRGC 2297
Query: 451 LSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGGG 510
+ DP + + + I + F T PNGLLL+
Sbjct: 2298 FGSSQNE----DPSFHFDGSGYSVVEKSLPATVTQIIMLFNTFSPNGLLLY--------- 2344
Query: 511 AGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGS 570
GS+ + D+ ++EL G + ++ D+GSG I L + R+ N+G W + FQR+ ++G
Sbjct: 2345 LGSYGT---KDFLSIELFRGRVKVMTDLGSGPITL-LTDRRYNNGTWYKIAFQRNRKQGV 2400
Query: 571 ISV-NSRSTPFLATGDSEILDLESEL--------YLGGLPEGGRVDLPLPPEVWTAALRA 621
++V ++ +T T E S+L Y+GGLP RV V
Sbjct: 2401 LAVIDAYNTSNKETKQGETPGASSDLNRLDKDPIYVGGLPR-SRV-------VRRGVTTK 2452
Query: 622 GYVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCREGWNRF 681
+VGC+++L I + DL + + GV K C P R+ + G+
Sbjct: 2453 SFVGCIKNLEISRSTFDL-----LRNSYGVR--------KGCLLEPIRSVSFLKGGY--- 2496
Query: 682 ICDCIGTGFLGRVCEREATVLSYDGSMYMKIMLPNAMHTEAEDVSLRFMSQRAYGLMMAT 741
I LP + + + F + + G+++A
Sbjct: 2497 ------------------------------IELPPKSLSPESEWLVTFATTNSSGIILAA 2526
Query: 742 T--------SRESADT--LRLELDGGQMKLTVNLGKGPETLFA-----GHKLNDNEWHTV 786
RE A + L GG +++ VN G G A +D + H++
Sbjct: 2527 LGGDVEKRGDREEAHVPFFSVMLIGGNIEVHVNPGDGTGLRKALLHAPTGTCSDGQAHSI 2586
Query: 787 RVVRRGKSLQLSVDNVTVEGQMAGAHMRLEFHNIE------------TGIMTERRFISVV 834
+VR + + + +D G + N+ T ++T RR
Sbjct: 2587 SLVRNRRIITVQLDENNPVEMKLGTLVESRTINVSNLYVGGIPEGEGTSLLTMRRSFHGC 2646
Query: 835 PSNFIGHLSGLVFNGQPYMDQCKDGDITYCELNARFGL------RAIVADPVTFKSRSSY 888
N I +L L FN +Q D+ C L+ R L ++ +P F +
Sbjct: 2647 IKNLIFNLELLDFNSAVGHEQV---DLDTCWLSERPKLAPDAEDSKLLPEPRAFPEQC-- 2701
Query: 889 LALATLQAYASMHLF------------------------FQFKTTAPDGLLLFNS-GNGN 923
+ A L+ H F +T A GL+ + + N
Sbjct: 2702 VVDAALEYVPGAHQFGLTQNSHFILPFNQSAVRKKLSVELSIRTFASSGLIYYMAHQNQA 2761
Query: 924 DFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVS--RDPGNVHTLKIDSR 981
D+ V++L G +H++FDLG G + K + ++D +WH V + G + +S
Sbjct: 2762 DYAVLQLHGGRLHFMFDLGKGRT--KVSHPALLSDGKWHTVKTDYVKRKGFITVDGRESP 2819
Query: 982 TVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIAD 1041
VT +G LD++G Y+GGL + K+ C+ V +N + D
Sbjct: 2820 MVTVVGDGTM-LDVEGLFYLGGLPSQYQAR--KIGNITHSIPACIGDVTVNSKQLDK--- 2873
Query: 1042 ALHRIGQVERGCDGPSTTCTEESC---ANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTT 1098
D P + T C A +G T
Sbjct: 2874 ------------DSPVSAFTVNRCYAVAQEG----------------------------T 2893
Query: 1099 YIFGKGGALITYTWPPNDRPSTRMD-RLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQ 1157
Y G G A + + + D + + F T ++ VL+ + +A D + L +
Sbjct: 2894 YFDGSGYAALV-----KEGYKVQSDVNITLEFRTSSQNGVLLGISTAK--VDAIGLELVD 2946
Query: 1158 GTVGVIFNVGTDDITID-EPN--AIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGR 1214
G V N G IT EP ++ DGK+H ++ +S TL VD V P
Sbjct: 2947 GKVLFHVNNGAGRITAAYEPKTATVLCDGKWHTLQANKSKHRITLIVDGNAVGAESP-HT 3005
Query: 1215 QLTIFNSQAAIKIGGRDQG 1233
Q T ++ I +GG G
Sbjct: 3006 QSTSVDTNNPIYVGGYPAG 3024
Score = 46.6 bits (109), Expect = 2e-04
Identities = 46/173 (26%), Positives = 69/173 (39%), Gaps = 17/173 (9%)
Query: 23 AARADGLEFGGGPGQWARYARWAGAASSGELSFSLRTNATRALLLYLDDGGDCDFLELLL 82
A +G F G G A S ++ RT++ +LL + D + L L
Sbjct: 2887 AVAQEGTYFDGS-GYAALVKEGYKVQSDVNITLEFRTSSQNGVLLGISTA-KVDAIGLEL 2944
Query: 83 VDGRLRLRFT------LSCAEPATLQLDTPVADDRWHMVLLTRDARRTALAVDGEARAAE 136
VDG++ + EP T T + D +WH + + R L VDG A AE
Sbjct: 2945 VDGKVLFHVNNGAGRITAAYEPKTA---TVLCDGKWHTLQANKSKHRITLIVDGNAVGAE 3001
Query: 137 -VRSKRREMQVASDLFVGGIPPDVRLSALTLSTVKYEPPFRGLLANLKLGERP 188
++ + + ++VGG P V+ L T FRG L L L + P
Sbjct: 3002 SPHTQSTSVDTNNPIYVGGYPAGVKQKCLRSQT-----SFRGCLRKLALIKSP 3049
Score = 45.8 bits (107), Expect = 3e-04
Identities = 47/171 (27%), Positives = 74/171 (43%), Gaps = 21/171 (12%)
Query: 48 ASSGELSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPV 107
A+ ++ T + LLLYL G DFL + L GR+++ L + P TL D
Sbjct: 2324 ATVTQIIMLFNTFSPNGLLLYLGSYGTKDFLSIELFRGRVKVMTDLG-SGPITLLTDRRY 2382
Query: 108 ADDRWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASD---------LFVGGIPPD 158
+ W+ + R+ ++ LAV + +K+ E AS ++VGG+P
Sbjct: 2383 NNGTWYKIAFQRNRKQGVLAVIDAYNTSNKETKQGETPGASSDLNRLDKDPIYVGGLPRS 2442
Query: 159 --VRLSALTLSTVKYEPPFRGLLANLKLGERPPALL-GSQGLR-GATADPL 205
VR T S F G + NL++ LL S G+R G +P+
Sbjct: 2443 RVVRRGVTTKS-------FVGCIKNLEISRSTFDLLRNSYGVRKGCLLEPI 2486
>gi|239743756 PREDICTED: hypothetical protein LOC389722 isoform 2
[Homo sapiens]
Length = 1207
Score = 135 bits (341), Expect = 2e-31
Identities = 119/446 (26%), Positives = 191/446 (42%), Gaps = 60/446 (13%)
Query: 265 VATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHT-GKSADYVNLSLKSGAVW 323
V F G Y L P++ D I+L F+ +Q NG++LH G+ +++ L L G +
Sbjct: 183 VVYFDGQSALLYTLDKKPLKPIRDVISLKFKAMQSNGILLHREGQHGNHITLELIKGKLV 242
Query: 324 LVINLGSGAFEALVEPVN----GKFNDNAWHDVRVTRNLRQHAGIGHAMVTISVDGILTT 379
+N G+ + + PV +D WH V + + V +VD T
Sbjct: 243 FFLNSGNAKLPSTIAPVTLTLGSLLDDQHWHSVLIE--------LLDTQVNFTVDKH-TH 293
Query: 380 TGYTQEDYTMLGSDDFFYIGG--SPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRL 437
+ D + L + GG SP + + +F GCL+++ Y D ++ L
Sbjct: 294 HFQAKGDSSNLDLNFEISFGGILSPGRSR---AFTRKSFHGCLENLYYNGVD----VTEL 346
Query: 438 AKEGDPKMKLQGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNG 497
AK+ P++ + G++SF C + PVTF S +++ALP S + S++ FRT G
Sbjct: 347 AKKHKPQILMMGNVSFSCPQPQTV-PVTFLSSRSYLALPGNSGEDKVSVTFQFRTWNRAG 405
Query: 498 LLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEW 557
LLF + +R G F + L DG L L L + + +NDG+W
Sbjct: 406 HLLFGELQRGSGS------------FVLFLKDGKLKLSLFQAGQSPRNVTAGAGLNDGQW 453
Query: 558 CHVDFQRDGRKGSISVNSRST--PFLATGDSEILDLESELYLGGL---PEGGRVDLPLPP 612
V F ++ V+ + P +A ++D Y GG G PL
Sbjct: 454 HSVSFSAKWSHMNVVVDDDTAVQPLVAV----LIDSGDTYYFGGCLGNSSGSGCKSPL-- 507
Query: 613 EVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGV---APFCSRETLKQCASAPCR 669
G+ GC+R + I ++ D + QGA+G S +C + C
Sbjct: 508 --------GGFQGCLRLITIGDKAVD--PILVQQGALGSFRDLQIDSCGITDRCLPSYCE 557
Query: 670 NGGVCREGWNRFICDCIGTGFLGRVC 695
+GG C + W+ F CDC+GTG+ G C
Sbjct: 558 HGGECSQSWDTFSCDCLGTGYTGETC 583
Score = 118 bits (295), Expect = 5e-26
Identities = 112/415 (26%), Positives = 173/415 (41%), Gaps = 23/415 (5%)
Query: 695 CEREATVLSYDGSMYMKIMLPNAMHTEAEDV-SLRFMSQRAYGLMMATTSRESADTLRLE 753
C ++ V+ +DG + L DV SL+F + ++ G+++ + + + LE
Sbjct: 177 CAYKSEVVYFDGQSALLYTLDKKPLKPIRDVISLKFKAMQSNGILLHREGQHG-NHITLE 235
Query: 754 LDGGQMKLTVNLGKG-------PETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDNVTVEG 806
L G++ +N G P TL G L+D WH+V + + +VD T
Sbjct: 236 LIKGKLVFFLNSGNAKLPSTIAPVTLTLGSLLDDQHWHSVLIELLDTQVNFTVDKHTHHF 295
Query: 807 QMAG--AHMRLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDGDITYC 864
Q G +++ L F GI++ R + +F G L L +NG + K
Sbjct: 296 QAKGDSSNLDLNFEISFGGILSPGRSRAFTRKSFHGCLENLYYNGVDVTELAKKHKPQIL 355
Query: 865 EL-NARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNS-GNG 922
+ N F PVTF S SYLAL + + FQF+T G LLF G
Sbjct: 356 MMGNVSFSCPQPQTVPVTFLSSRSYLALPGNSGEDKVSVTFQFRTWNRAGHLLFGELQRG 415
Query: 923 NDFIVIELVKGYIHY-VFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSR 981
+ V+ L G + +F G P + + +ND QWH+V S +++ + +D
Sbjct: 416 SGSFVLFLKDGKLKLSLFQAGQSPRNVTAGAG--LNDGQWHSVSFSAKWSHMNVV-VDDD 472
Query: 982 TVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIA- 1040
T Q +D Y GG N + K + GFQGCL + + + D I
Sbjct: 473 TAVQPLVAVL-IDSGDTYYFGGCLGNSSGSGCK--SPLGGFQGCLRLITIGDKAVDPILV 529
Query: 1041 --DALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCN 1093
AL ++ G + C C + G C Q WD F+CDC T Y G C+
Sbjct: 530 QQGALGSFRDLQIDSCGITDRCLPSYCEHGGECSQSWDTFSCDCLGTGYTGETCH 584
Score = 60.1 bits (144), Expect = 2e-08
Identities = 39/124 (31%), Positives = 61/124 (49%), Gaps = 4/124 (3%)
Query: 881 TFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSGNGNDFIVIEL-VKGYIHYVF 939
+F + +SYL + + F FKTT G+ + N G DFI IEL + + F
Sbjct: 795 SFNTETSYLHFPAFHGELTADVCFFFKTTVSSGVFMENLGI-TDFIRIELRAPTEVTFSF 853
Query: 940 DLGNGPSLMKGNSDKPVNDNQWHNVVVSRD--PGNVHTLKIDSRTVTQHSNGARNLDLKG 997
D+GNGP + S P NDNQWH+V R+ ++ ++ + ++G L L
Sbjct: 854 DVGNGPCEVTVQSPTPFNDNQWHHVRAERNVKGASLQVDQLPQKMQPAPADGHVRLQLNS 913
Query: 998 ELYI 1001
+L+I
Sbjct: 914 QLFI 917
Score = 45.8 bits (107), Expect = 3e-04
Identities = 73/331 (22%), Positives = 122/331 (36%), Gaps = 51/331 (15%)
Query: 717 AMHTE-AEDVSLRFMSQRAYGLMMATTSRESADTLRLELDGG-QMKLTVNLGKGP--ETL 772
A H E DV F + + G+ M D +R+EL ++ + ++G GP T+
Sbjct: 807 AFHGELTADVCFFFKTTVSSGVFMENLG--ITDFIRIELRAPTEVTFSFDVGNGPCEVTV 864
Query: 773 FAGHKLNDNEWHTVRVVRRGKSLQLSVDNVTVEGQMAGA--HMRLEFHNIETGIMTERRF 830
+ NDN+WH VR R K L VD + + Q A A H+RL+ + + F
Sbjct: 865 QSPTPFNDNQWHHVRAERNVKGASLQVDQLPQKMQPAPADGHVRLQ--------LNSQLF 916
Query: 831 ISVVPSNFIGHLSGLVFNGQPYMDQCKDGDITYCELNARFGLRAIVADPVTFKSRSSYLA 890
I + S + S + ++ Q + T SS L
Sbjct: 917 IEI--SAYFATGSSMTYHFQEH---------------------------YTLSENSSSLV 947
Query: 891 LATLQ--AYASMHLFFQFKTTAPDGLLLFNSGNGNDFIVIELVKG---YIHYVFDLGNGP 945
+ + + F+TT LLL+ S +++ + L I Y D P
Sbjct: 948 SSLYRDVTLTREMITLSFRTTRSPSLLLYVSSFYEEYLSVILANNGSLQIRYKLDRHQNP 1007
Query: 946 SLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGARNLDLKGELYIGGLS 1005
+ K + D Q H V ++R+ V S + + L +G +
Sbjct: 1008 DAFTFDF-KNMADGQLHQVKINREEAVVMVEVNQSAKKQVILSSGTEFNAVKSLILGKVL 1066
Query: 1006 KNMFSNLPKLVASRDGFQGCLASVDLNGRLP 1036
+ ++ A+ GF GCL++V P
Sbjct: 1067 EAAGADPDTRRAATSGFTGCLSAVRFGRAAP 1097
Score = 40.0 bits (92), Expect = 0.019
Identities = 21/74 (28%), Positives = 38/74 (51%), Gaps = 2/74 (2%)
Query: 287 TDEITLAFRTLQRNGLMLHTGKSADYVNLSLKSGA-VWLVINLGSGAFEALVEPVNGKFN 345
T ++ F+T +G+ + D++ + L++ V ++G+G E V+ FN
Sbjct: 813 TADVCFFFKTTVSSGVFMENLGITDFIRIELRAPTEVTFSFDVGNGPCEVTVQSPT-PFN 871
Query: 346 DNAWHDVRVTRNLR 359
DN WH VR RN++
Sbjct: 872 DNQWHHVRAERNVK 885
Score = 38.9 bits (89), Expect = 0.041
Identities = 45/175 (25%), Positives = 74/175 (42%), Gaps = 21/175 (12%)
Query: 53 LSFSLRTNATRALLLYLDDGGDCDFLELLLVD-GRLRLRFTLSCAE-PATLQLDTP-VAD 109
++ S RT + +LLLY+ + ++L ++L + G L++R+ L + P D +AD
Sbjct: 961 ITLSFRTTRSPSLLLYVSSFYE-EYLSVILANNGSLQIRYKLDRHQNPDAFTFDFKNMAD 1019
Query: 110 DRWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVG------GIPPDVRLSA 163
+ H V + R+ + V+ A+ + S E L +G G PD R +A
Sbjct: 1020 GQLHQVKINREEAVVMVEVNQSAKKQVILSSGTEFNAVKSLILGKVLEAAGADPDTRRAA 1079
Query: 164 LTLSTVKYEPPFRGLLANLKLGERPP--ALLGSQGLRGATADPLCAPARNPCANG 216
+ F G L+ ++ G P A L G T AP CA G
Sbjct: 1080 TS--------GFTGCLSAVRFGRAAPLKAALRPSGPSRVTVRGHVAPMAR-CAAG 1125
Score = 33.5 bits (75), Expect = 1.7
Identities = 31/146 (21%), Positives = 63/146 (43%), Gaps = 20/146 (13%)
Query: 457 DVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSS 516
D + + +F + +++ P + + T + F+TT +G+ + + G
Sbjct: 787 DKSFWNSASFNTETSYLHFPAFHGELTADVCFFFKTTVSSGVFMENLGI----------- 835
Query: 517 AQRADYFAMEL-LDGHLYLLLDMGSGGIKLRASS-RKVNDGEWCHVDFQRDGRKGSISVN 574
D+ +EL + D+G+G ++ S ND +W HV +R+ + S+ V+
Sbjct: 836 ---TDFIRIELRAPTEVTFSFDVGNGPCEVTVQSPTPFNDNQWHHVRAERNVKGASLQVD 892
Query: 575 ---SRSTPFLATGDSEILDLESELYL 597
+ P A G L L S+L++
Sbjct: 893 QLPQKMQPAPADGHVR-LQLNSQLFI 917
Score = 32.7 bits (73), Expect = 3.0
Identities = 28/88 (31%), Positives = 45/88 (51%), Gaps = 8/88 (9%)
Query: 1146 GLGDYLQLHIDQGT-VGVIFNVGTD--DITIDEPNAIVSDGKYHVVRFTRSGGNATLQVD 1202
G+ D++++ + T V F+VG ++T+ P +D ++H VR R+ A+LQVD
Sbjct: 834 GITDFIRIELRAPTEVTFSFDVGNGPCEVTVQSPTPF-NDNQWHHVRAERNVKGASLQVD 892
Query: 1203 SWPVNERYPA---GRQLTIFNSQAAIKI 1227
P + PA G NSQ I+I
Sbjct: 893 QLP-QKMQPAPADGHVRLQLNSQLFIEI 919
Score = 32.3 bits (72), Expect = 3.9
Identities = 27/105 (25%), Positives = 41/105 (39%), Gaps = 9/105 (8%)
Query: 78 LELLLVDGRLRLRFTLSCAEPATLQLDTPVADDRWHMVLLTRDARRTALAVDGEARAAEV 137
L L G +L T++ P TL L + + D WH VL+ + VD +
Sbjct: 241 LVFFLNSGNAKLPSTIA---PVTLTLGSLLDDQHWHSVLIELLDTQVNFTVDKHTHHFQA 297
Query: 138 RSKRREMQVASDLFVGGIPPDVRLSALTLSTVKYEPPFRGLLANL 182
+ + + ++ GGI R A T + F G L NL
Sbjct: 298 KGDSSNLDLNFEISFGGILSPGRSRAFTRKS------FHGCLENL 336
>gi|239743754 PREDICTED: hypothetical protein LOC389722 isoform 1
[Homo sapiens]
Length = 1288
Score = 135 bits (341), Expect = 2e-31
Identities = 119/446 (26%), Positives = 191/446 (42%), Gaps = 60/446 (13%)
Query: 265 VATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHT-GKSADYVNLSLKSGAVW 323
V F G Y L P++ D I+L F+ +Q NG++LH G+ +++ L L G +
Sbjct: 183 VVYFDGQSALLYTLDKKPLKPIRDVISLKFKAMQSNGILLHREGQHGNHITLELIKGKLV 242
Query: 324 LVINLGSGAFEALVEPVN----GKFNDNAWHDVRVTRNLRQHAGIGHAMVTISVDGILTT 379
+N G+ + + PV +D WH V + + V +VD T
Sbjct: 243 FFLNSGNAKLPSTIAPVTLTLGSLLDDQHWHSVLIE--------LLDTQVNFTVDKH-TH 293
Query: 380 TGYTQEDYTMLGSDDFFYIGG--SPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRL 437
+ D + L + GG SP + + +F GCL+++ Y D ++ L
Sbjct: 294 HFQAKGDSSNLDLNFEISFGGILSPGRSR---AFTRKSFHGCLENLYYNGVD----VTEL 346
Query: 438 AKEGDPKMKLQGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNG 497
AK+ P++ + G++SF C + PVTF S +++ALP S + S++ FRT G
Sbjct: 347 AKKHKPQILMMGNVSFSCPQPQTV-PVTFLSSRSYLALPGNSGEDKVSVTFQFRTWNRAG 405
Query: 498 LLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEW 557
LLF + +R G F + L DG L L L + + +NDG+W
Sbjct: 406 HLLFGELQRGSGS------------FVLFLKDGKLKLSLFQAGQSPRNVTAGAGLNDGQW 453
Query: 558 CHVDFQRDGRKGSISVNSRST--PFLATGDSEILDLESELYLGGL---PEGGRVDLPLPP 612
V F ++ V+ + P +A ++D Y GG G PL
Sbjct: 454 HSVSFSAKWSHMNVVVDDDTAVQPLVAV----LIDSGDTYYFGGCLGNSSGSGCKSPL-- 507
Query: 613 EVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGV---APFCSRETLKQCASAPCR 669
G+ GC+R + I ++ D + QGA+G S +C + C
Sbjct: 508 --------GGFQGCLRLITIGDKAVD--PILVQQGALGSFRDLQIDSCGITDRCLPSYCE 557
Query: 670 NGGVCREGWNRFICDCIGTGFLGRVC 695
+GG C + W+ F CDC+GTG+ G C
Sbjct: 558 HGGECSQSWDTFSCDCLGTGYTGETC 583
Score = 118 bits (295), Expect = 5e-26
Identities = 112/415 (26%), Positives = 173/415 (41%), Gaps = 23/415 (5%)
Query: 695 CEREATVLSYDGSMYMKIMLPNAMHTEAEDV-SLRFMSQRAYGLMMATTSRESADTLRLE 753
C ++ V+ +DG + L DV SL+F + ++ G+++ + + + LE
Sbjct: 177 CAYKSEVVYFDGQSALLYTLDKKPLKPIRDVISLKFKAMQSNGILLHREGQHG-NHITLE 235
Query: 754 LDGGQMKLTVNLGKG-------PETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDNVTVEG 806
L G++ +N G P TL G L+D WH+V + + +VD T
Sbjct: 236 LIKGKLVFFLNSGNAKLPSTIAPVTLTLGSLLDDQHWHSVLIELLDTQVNFTVDKHTHHF 295
Query: 807 QMAG--AHMRLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDGDITYC 864
Q G +++ L F GI++ R + +F G L L +NG + K
Sbjct: 296 QAKGDSSNLDLNFEISFGGILSPGRSRAFTRKSFHGCLENLYYNGVDVTELAKKHKPQIL 355
Query: 865 EL-NARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNS-GNG 922
+ N F PVTF S SYLAL + + FQF+T G LLF G
Sbjct: 356 MMGNVSFSCPQPQTVPVTFLSSRSYLALPGNSGEDKVSVTFQFRTWNRAGHLLFGELQRG 415
Query: 923 NDFIVIELVKGYIHY-VFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSR 981
+ V+ L G + +F G P + + +ND QWH+V S +++ + +D
Sbjct: 416 SGSFVLFLKDGKLKLSLFQAGQSPRNVTAGAG--LNDGQWHSVSFSAKWSHMNVV-VDDD 472
Query: 982 TVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIA- 1040
T Q +D Y GG N + K + GFQGCL + + + D I
Sbjct: 473 TAVQPLVAVL-IDSGDTYYFGGCLGNSSGSGCK--SPLGGFQGCLRLITIGDKAVDPILV 529
Query: 1041 --DALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCN 1093
AL ++ G + C C + G C Q WD F+CDC T Y G C+
Sbjct: 530 QQGALGSFRDLQIDSCGITDRCLPSYCEHGGECSQSWDTFSCDCLGTGYTGETCH 584
Score = 111 bits (278), Expect = 5e-24
Identities = 99/345 (28%), Positives = 159/345 (46%), Gaps = 43/345 (12%)
Query: 881 TFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSGNGNDFIVIEL-VKGYIHYVF 939
+F + +SYL + + F FKTT G+ + N G DFI IEL + + F
Sbjct: 796 SFNTETSYLHFPAFHGELTADVCFFFKTTVSSGVFMENLGI-TDFIRIELRAPTEVTFSF 854
Query: 940 DLGNGPSLMKGNSDKPVNDNQWHNVVVSRD--PGNVHTLKIDSRTVTQHSNGARNLDLKG 997
D+GNGP + S P NDNQWH+V R+ ++ ++ + ++G L L
Sbjct: 855 DVGNGPCEVTVQSPTPFNDNQWHHVRAERNVKGASLQVDQLPQKMQPAPADGHVRLQLNS 914
Query: 998 ELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPS 1057
+L+IGG + + GF GC+ S+ LNG DL A G VE GC G
Sbjct: 915 QLFIGGTA-----------TRQRGFLGCIRSLQLNGVALDLEERATVTPG-VEPGCAGHC 962
Query: 1058 TTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALI-----TYTW 1112
+T C N G C ++ G TCDC ++Y GP C++ + Y F G ++ YT
Sbjct: 963 ST-YGHLCRNGGRCREKRRGVTCDCAFSAYDGPFCSNEISAY-FATGSSMTYHFQEHYTL 1020
Query: 1113 PPN----------DRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHI-DQGTVG 1161
N D TR + + + F T + ++L+ V +S +YL + + + G++
Sbjct: 1021 SENSSSLVSSLYRDVTLTR-EMITLSFRTTRSPSLLLYV--SSFYEEYLSVILANNGSLQ 1077
Query: 1162 VIFNV----GTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVD 1202
+ + + D T D N ++DG+ H V+ R ++V+
Sbjct: 1078 IRYKLDRHQNPDAFTFDFKN--MADGQLHQVKINREEAVVMVEVN 1120
Score = 74.3 bits (181), Expect = 9e-13
Identities = 82/371 (22%), Positives = 152/371 (40%), Gaps = 65/371 (17%)
Query: 457 DVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSS 516
D + + +F + +++ P + + T + F+TT +G+ + + G
Sbjct: 788 DKSFWNSASFNTETSYLHFPAFHGELTADVCFFFKTTVSSGVFMENLGI----------- 836
Query: 517 AQRADYFAMEL-LDGHLYLLLDMGSGGIKLRASS-RKVNDGEWCHVDFQRDGRKGSISVN 574
D+ +EL + D+G+G ++ S ND +W HV +R+ + S+ V+
Sbjct: 837 ---TDFIRIELRAPTEVTFSFDVGNGPCEVTVQSPTPFNDNQWHHVRAERNVKGASLQVD 893
Query: 575 S---RSTPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLF 631
+ P A G L L S+L++GG TA + G++GC+R L
Sbjct: 894 QLPQKMQPAPADGHVR-LQLNSQLFIGG----------------TATRQRGFLGCIRSLQ 936
Query: 632 IDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAP--CRNGGVCREGWNRFICDCIGTG 689
++G + DL A GV P C+ C++ CRNGG CRE CDC +
Sbjct: 937 LNGVALDLEERATV--TPGVEPGCAGH----CSTYGHLCRNGGRCREKRRGVTCDCAFSA 990
Query: 690 FLGRVCEREAT-----------------VLSYDGSMYMKIMLPNAMHTEAEDVSLRFMSQ 732
+ G C E + LS + S + + + T E ++L F +
Sbjct: 991 YDGPFCSNEISAYFATGSSMTYHFQEHYTLSENSSSLVSSLYRDVTLTR-EMITLSFRTT 1049
Query: 733 RAYGLMMATTS--RESADTLRLELDGGQMKLTVNLGKGPETL-FAGHKLNDNEWHTVRVV 789
R+ L++ +S E + Q++ ++ + P+ F + D + H V++
Sbjct: 1050 RSPSLLLYVSSFYEEYLSVILANNGSLQIRYKLDRHQNPDAFTFDFKNMADGQLHQVKIN 1109
Query: 790 RRGKSLQLSVD 800
R + + V+
Sbjct: 1110 REEAVVMVEVN 1120
Score = 55.1 bits (131), Expect = 6e-07
Identities = 57/218 (26%), Positives = 86/218 (39%), Gaps = 36/218 (16%)
Query: 100 TLQLDTPVADDRWHMVLLTRDARRTALAVD--GEARAAEVRSKRREMQVASDLFVGGIPP 157
T+Q TP D++WH V R+ + +L VD + +Q+ S LF+GG
Sbjct: 864 TVQSPTPFNDNQWHHVRAERNVKGASLQVDQLPQKMQPAPADGHVRLQLNSQLFIGG--- 920
Query: 158 DVRLSALTLSTVKYEPPFRGLLANLKLG-------ERPPALLGSQ-GLRGATADPLCAPA 209
T + F G + +L+L ER G + G G C+
Sbjct: 921 ----------TATRQRGFLGCIRSLQLNGVALDLEERATVTPGVEPGCAGH-----CSTY 965
Query: 210 RNPCANGGLCTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEGKEEFVA--T 267
+ C NGG C G V CDC+ + + G FCS E A+ S F T
Sbjct: 966 GHLCRNGGRCREKRRG-VTCDCAFSAYDGPFCSNEI-----SAYFATGSSMTYHFQEHYT 1019
Query: 268 FKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLH 305
N + + + + ITL+FRT + L+L+
Sbjct: 1020 LSENSSSLVSSLYRDVTLTREMITLSFRTTRSPSLLLY 1057
Score = 47.0 bits (110), Expect = 2e-04
Identities = 84/381 (22%), Positives = 138/381 (36%), Gaps = 71/381 (18%)
Query: 717 AMHTE-AEDVSLRFMSQRAYGLMMATTSRESADTLRLELDGG-QMKLTVNLGKGP--ETL 772
A H E DV F + + G+ M D +R+EL ++ + ++G GP T+
Sbjct: 808 AFHGELTADVCFFFKTTVSSGVFMENLG--ITDFIRIELRAPTEVTFSFDVGNGPCEVTV 865
Query: 773 FAGHKLNDNEWHTVRVVRRGKSLQLSVDNVTVEGQMAGA--HMRLEFHN--IETGIMTER 828
+ NDN+WH VR R K L VD + + Q A A H+RL+ ++ G T +
Sbjct: 866 QSPTPFNDNQWHHVRAERNVKGASLQVDQLPQKMQPAPADGHVRLQLNSQLFIGGTATRQ 925
Query: 829 RFISVVPSNFIGHLSGLVFNG-----------------------QPYMDQCKDG------ 859
R F+G + L NG Y C++G
Sbjct: 926 R-------GFLGCIRSLQLNGVALDLEERATVTPGVEPGCAGHCSTYGHLCRNGGRCREK 978
Query: 860 -------------DITYC--ELNARFGLRAIVA----DPVTFKSRSSYLALATLQ--AYA 898
D +C E++A F + + + T SS L + +
Sbjct: 979 RRGVTCDCAFSAYDGPFCSNEISAYFATGSSMTYHFQEHYTLSENSSSLVSSLYRDVTLT 1038
Query: 899 SMHLFFQFKTTAPDGLLLFNSGNGNDFIVIELVKG---YIHYVFDLGNGPSLMKGNSDKP 955
+ F+TT LLL+ S +++ + L I Y D P + K
Sbjct: 1039 REMITLSFRTTRSPSLLLYVSSFYEEYLSVILANNGSLQIRYKLDRHQNPDAFTFDF-KN 1097
Query: 956 VNDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKL 1015
+ D Q H V ++R+ V S + + L +G + + ++
Sbjct: 1098 MADGQLHQVKINREEAVVMVEVNQSAKKQVILSSGTEFNAVKSLILGKVLEAAGADPDTR 1157
Query: 1016 VASRDGFQGCLASVDLNGRLP 1036
A+ GF GCL++V P
Sbjct: 1158 RAATSGFTGCLSAVRFGRAAP 1178
Score = 40.0 bits (92), Expect = 0.019
Identities = 21/74 (28%), Positives = 38/74 (51%), Gaps = 2/74 (2%)
Query: 287 TDEITLAFRTLQRNGLMLHTGKSADYVNLSLKSGA-VWLVINLGSGAFEALVEPVNGKFN 345
T ++ F+T +G+ + D++ + L++ V ++G+G E V+ FN
Sbjct: 814 TADVCFFFKTTVSSGVFMENLGITDFIRIELRAPTEVTFSFDVGNGPCEVTVQSPT-PFN 872
Query: 346 DNAWHDVRVTRNLR 359
DN WH VR RN++
Sbjct: 873 DNQWHHVRAERNVK 886
Score = 38.9 bits (89), Expect = 0.041
Identities = 45/175 (25%), Positives = 74/175 (42%), Gaps = 21/175 (12%)
Query: 53 LSFSLRTNATRALLLYLDDGGDCDFLELLLVD-GRLRLRFTLSCAE-PATLQLDTP-VAD 109
++ S RT + +LLLY+ + ++L ++L + G L++R+ L + P D +AD
Sbjct: 1042 ITLSFRTTRSPSLLLYVSSFYE-EYLSVILANNGSLQIRYKLDRHQNPDAFTFDFKNMAD 1100
Query: 110 DRWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVG------GIPPDVRLSA 163
+ H V + R+ + V+ A+ + S E L +G G PD R +A
Sbjct: 1101 GQLHQVKINREEAVVMVEVNQSAKKQVILSSGTEFNAVKSLILGKVLEAAGADPDTRRAA 1160
Query: 164 LTLSTVKYEPPFRGLLANLKLGERPP--ALLGSQGLRGATADPLCAPARNPCANG 216
+ F G L+ ++ G P A L G T AP CA G
Sbjct: 1161 TS--------GFTGCLSAVRFGRAAPLKAALRPSGPSRVTVRGHVAPMAR-CAAG 1206
Score = 36.2 bits (82), Expect = 0.27
Identities = 34/109 (31%), Positives = 53/109 (48%), Gaps = 9/109 (8%)
Query: 1146 GLGDYLQLHIDQGT-VGVIFNVGTD--DITIDEPNAIVSDGKYHVVRFTRSGGNATLQVD 1202
G+ D++++ + T V F+VG ++T+ P +D ++H VR R+ A+LQVD
Sbjct: 835 GITDFIRIELRAPTEVTFSFDVGNGPCEVTVQSPTPF-NDNQWHHVRAERNVKGASLQVD 893
Query: 1203 SWPVNERYPA---GRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGL 1248
P + PA G NSQ I G + R F G + L NG+
Sbjct: 894 QLP-QKMQPAPADGHVRLQLNSQLFIG-GTATRQRGFLGCIRSLQLNGV 940
Score = 32.3 bits (72), Expect = 3.9
Identities = 27/105 (25%), Positives = 41/105 (39%), Gaps = 9/105 (8%)
Query: 78 LELLLVDGRLRLRFTLSCAEPATLQLDTPVADDRWHMVLLTRDARRTALAVDGEARAAEV 137
L L G +L T++ P TL L + + D WH VL+ + VD +
Sbjct: 241 LVFFLNSGNAKLPSTIA---PVTLTLGSLLDDQHWHSVLIELLDTQVNFTVDKHTHHFQA 297
Query: 138 RSKRREMQVASDLFVGGIPPDVRLSALTLSTVKYEPPFRGLLANL 182
+ + + ++ GGI R A T + F G L NL
Sbjct: 298 KGDSSNLDLNFEISFGGILSPGRSRAFTRKS------FHGCLENL 336
>gi|4505463 contactin associated protein 1 precursor [Homo sapiens]
Length = 1384
Score = 133 bits (335), Expect = 1e-30
Identities = 118/442 (26%), Positives = 190/442 (42%), Gaps = 56/442 (12%)
Query: 268 FKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHT-GKSADYVNLSLKSGAVWLVI 326
F G++ Y +S D +F+T +++GL+LH G DYV L L+ + L +
Sbjct: 177 FDGDDAISYRFPRGVSRSLWDVFAFSFKTEEKDGLLLHAEGAQGDYVTLELEGAHLLLHM 236
Query: 327 NLGSGAFEA----LVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVTISVDGILTTTGY 382
+LGS + G ND WH VRV R R D T GY
Sbjct: 237 SLGSSPIQPRPGHTTVSAGGVLNDQHWHYVRVDRFGR--------------DVNFTLDGY 282
Query: 383 TQE-----DYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRL 437
Q D+ L D +IGG A +NF GC+++V++ ++ ++ L
Sbjct: 283 VQRFILNGDFERLNLDTEMFIGGLVGAAR-KNLAYRHNFRGCIENVIFN----RVNIADL 337
Query: 438 AKEGDPKMKLQGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNG 497
A ++ +G ++FRC D P+ F P FV +P + + ++S FRT + G
Sbjct: 338 AVRRHSRITFEGKVAFRCLDPVP-HPINFGGPHNFVQVPGFPRRGRLAVSFRFRTWDLTG 396
Query: 498 LLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLR-ASSRKVNDGE 556
LLLFS R G G G + + L +G + + + SG KL+ A+ ++NDG
Sbjct: 397 LLLFS---RLGDGLG---------HVELTLSEGQVNVSIAQ-SGRKKLQFAAGYRLNDGF 443
Query: 557 WCHVDFQRDGRKGSISVNSRSTPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWT 616
W V+F IS++ + ++ + + GG P+ P W
Sbjct: 444 WHEVNFVAQENHAVISIDDVEGAEVRVSYPLLIRTGTSYFFGGCPK--------PASRWD 495
Query: 617 A-ALRAGYVGCVRDLFIDGRSRDLRGLAEAQ--GAVGVAPFCSRETLKQCASAPCRNGGV 673
+ + + GC+ L +DG+ +L L E + G F + +C+ C + G
Sbjct: 496 CHSNQTAFHGCMELLKVDGQLVNLT-LVEGRRLGFYAEVLFDTCGITDRCSPNMCEHDGR 554
Query: 674 CREGWNRFICDCIGTGFLGRVC 695
C + W+ FIC C TG+ G C
Sbjct: 555 CYQSWDDFICYCELTGYKGETC 576
Score = 112 bits (279), Expect = 4e-24
Identities = 110/427 (25%), Positives = 183/427 (42%), Gaps = 41/427 (9%)
Query: 695 CEREATVLSYDGSMYMKIMLPNAMHTEAEDV-SLRFMSQRAYGLMMATTSRESADTLRLE 753
C +A +L +DG + P + DV + F ++ GL++ + D + LE
Sbjct: 168 CPYKADILYFDGDDAISYRFPRGVSRSLWDVFAFSFKTEEKDGLLLHAEGAQG-DYVTLE 226
Query: 754 LDGGQMKLTVNLGKGP-------ETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDNVTVEG 806
L+G + L ++LG P T+ AG LND WH VRV R G+ + ++D
Sbjct: 227 LEGAHLLLHMSLGSSPIQPRPGHTTVSAGGVLNDQHWHYVRVDRFGRDVNFTLDGYVQRF 286
Query: 807 QMAGAHMRLEFHNIET-----GIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQC--KDG 859
+ G RL N++T G++ R NF G + ++FN D +
Sbjct: 287 ILNGDFERL---NLDTEMFIGGLVGAARKNLAYRHNFRGCIENVIFNRVNIADLAVRRHS 343
Query: 860 DITYCELNARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNS 919
IT+ E F V P+ F +++ + + + F+F+T GLLLF+
Sbjct: 344 RITF-EGKVAFRCLDPVPHPINFGGPHNFVQVPGFPRRGRLAVSFRFRTWDLTGLLLFSR 402
Query: 920 -GNGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNV-VVSRDPGNVHTLK 977
G+G + + L +G ++ V +G ++ + +ND WH V V+++ N +
Sbjct: 403 LGDGLGHVELTLSEGQVN-VSIAQSGRKKLQFAAGYRLNDGFWHEVNFVAQE--NHAVIS 459
Query: 978 IDSRTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRD------GFQGCLASVDL 1031
ID GA + + L I + F PK + D F GC+ + +
Sbjct: 460 IDD------VEGAE-VRVSYPLLIRTGTSYFFGGCPKPASRWDCHSNQTAFHGCMELLKV 512
Query: 1032 NGRLPDLIADALHRIG---QVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYG 1088
+G+L +L R+G +V G + C+ C + G C Q WD F C C +T Y
Sbjct: 513 DGQLVNLTLVEGRRLGFYAEVLFDTCGITDRCSPNMCEHDGRCYQSWDDFICYCELTGYK 572
Query: 1089 GPVCNDP 1095
G C+ P
Sbjct: 573 GETCHTP 579
Score = 89.7 bits (221), Expect = 2e-17
Identities = 116/491 (23%), Positives = 188/491 (38%), Gaps = 124/491 (25%)
Query: 889 LALATLQAYASMHLFFQFKTTAPDGLLLFNSGNG-----NDFIVIEL-VKGYIHYVFDLG 942
L ++A S+ + F F+T+AP G+ L N G ++ +EL + + FD+G
Sbjct: 796 LRFPPIRANHSLDVSFYFRTSAPSGVFLENMGGPYCQWRRPYVRVELNTSRDVVFAFDVG 855
Query: 943 NGPSLMKGNSDK-PVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGARN---LDLKGE 998
NG + +SD ND++WH V + L++D R + ++
Sbjct: 856 NGDENLTVHSDDFEFNDDEWHLVRAEINVKQAR-LRVDHRPWVLRPMPLQTYIWMEYDQP 914
Query: 999 LYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPST 1058
LY+G R F GCL ++ LNG +L A +G S
Sbjct: 915 LYVGSAE-----------LKRRPFVGCLRAMRLNGVTLNLEGRA--------NASEGTSP 955
Query: 1059 TCTEES------CANQGVCLQQWDGFTCDCTMTSYGGPVCN-------DPGTTYIFGKGG 1105
CT C + G C++++ +TCDC +T++ GP CN +PGT +
Sbjct: 956 NCTGHCAHPRLPCFHGGRCVERYSYYTCDCDLTAFDGPYCNHDIGGFFEPGTWMRYNLQS 1015
Query: 1106 ALIT-------------------------------------YTWPPNDRPSTRM------ 1122
AL + Y P RP +
Sbjct: 1016 ALRSAAREFSHMLSRPVPGYEPGYIPGYDTPGYVPGYHGPGYRLPDYPRPGRPVPGYRGP 1075
Query: 1123 ------DRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHI-DQGTVGVIFNVGTDDITIDE 1175
+ ++ FST AVL+ V +S + DY+ + I D GT+ + + +GT
Sbjct: 1076 VYNVTGEEVSFSFSTSSAPAVLLYV--SSFVRDYMAVLIKDDGTLQLRYQLGTSPYVYQL 1133
Query: 1176 PNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGRQLTIFNSQAAIKIG------- 1228
V+DG+ H + TR N +QVD +P+ E+ + + +S A+ +G
Sbjct: 1134 TTRPVTDGQPHSINITRVYRNLFIQVDYFPLTEQKFSLLVDSQLDSPKALYLGRVMETGV 1193
Query: 1229 -----GRDQGRPFQGQVSGLYYNGLKVL--------ALAAESDPNVRTEGHL-------- 1267
R F G +SG+ +N + L + AE +R +G L
Sbjct: 1194 IDPEIQRYNTPGFSGCLSGVRFNNVAPLKTHFRTPRPMTAELAEALRVQGELSESNCGAM 1253
Query: 1268 -RLVGEGPSVL 1277
RLV E P L
Sbjct: 1254 PRLVSEVPPEL 1264
Score = 79.3 bits (194), Expect = 3e-14
Identities = 160/712 (22%), Positives = 271/712 (38%), Gaps = 109/712 (15%)
Query: 53 LSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDRW 112
+SF RT LLL+ G +EL L +G++ + S + + D W
Sbjct: 385 VSFRFRTWDLTGLLLFSRLGDGLGHVELTLSEGQVNVSIAQSGRKKLQFAAGYRLNDGFW 444
Query: 113 HMVLLTRDARRTALAVDGEARAAEVR-SKRREMQVASDLFVGGIP-PDVRLSALTLSTVK 170
H V +++D + AEVR S ++ + F GG P P R + T
Sbjct: 445 HEVNFVAQENHAVISID-DVEGAEVRVSYPLLIRTGTSYFFGGCPKPASRWDCHSNQTA- 502
Query: 171 YEPPFRGLLANLKLGERPPALLGSQGLR-GATADPL---------CAPARNPCANGGLCT 220
F G + LK+ + L +G R G A+ L C+P N C + G C
Sbjct: 503 ----FHGCMELLKVDGQLVNLTLVEGRRLGFYAEVLFDTCGITDRCSP--NMCEHDGRC- 555
Query: 221 VLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEGKEEFVATFKGNEFFCYDLSH 280
+ + C C TG+ G+ C H L E E + + K + F D
Sbjct: 556 YQSWDDFICYCELTGYKGETC-----------HTPLYKESCEAYRLSGKTSGNFTID--- 601
Query: 281 NPIQSSTDEITLAFRTLQRNGLMLHTGKSADYVNLSLKSGAVWLVINLGSGAFEALVEPV 340
P S + + + ++ N ++ +W GS + +
Sbjct: 602 -PDGSGPLKPFVVYCDIRENRAWT-----------VVRHDRLWTTRVTGSSMERPFLGAI 649
Query: 341 NGKFNDNAWHDVRVTRNLRQHAGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYIGG 400
++ + +W +V N QH + + T GY + + FY GG
Sbjct: 650 --QYWNASWEEVSALANASQHCEQWIEFSCYNSRLLNTAGGYPYSFWIGRNEEQHFYWGG 707
Query: 401 SPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKE---------------GDPKM 445
S + + C+ +Y N D R K GD
Sbjct: 708 SQPGIQRCACGLDRS---CVDPALYCNCDADQPQWRTDKGLLTFVDHLPVTQVVIGDTNR 764
Query: 446 KLQGDLSF----RCE-DVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLL 500
F RC D + + ++F + A + P A + +S FRT+ P+G+ L
Sbjct: 765 STSEAQFFLRPLRCYGDRNSWNTISFHTGAA-LRFPPIRANHSLDVSFYFRTSAPSGVFL 823
Query: 501 FSQGRRAGGGAGSHSSAQRADYFAMELLDGH-LYLLLDMGSGGIKLRASSR--KVNDGEW 557
+ G G + +R Y +EL + D+G+G L S + ND EW
Sbjct: 824 ENMG-------GPYCQWRRP-YVRVELNTSRDVVFAFDVGNGDENLTVHSDDFEFNDDEW 875
Query: 558 CHVDFQRDGRKGSISVNSRSTPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTA 617
V + + ++ + V+ R P++ + L++ +++ D PL V +A
Sbjct: 876 HLVRAEINVKQARLRVDHR--PWVLRP----MPLQTYIWM-------EYDQPL--YVGSA 920
Query: 618 AL-RAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASA--PCRNGGVC 674
L R +VGC+R + ++G + +L G A A + G +P C+ CA PC +GG C
Sbjct: 921 ELKRRPFVGCLRAMRLNGVTLNLEGRANA--SEGTSPNCTGH----CAHPRLPCFHGGRC 974
Query: 675 REGWNRFICDCIGTGFLGRVCEREATVLSYDGSMYMKIMLPNAMHTEAEDVS 726
E ++ + CDC T F G C + ++ +M+ L +A+ + A + S
Sbjct: 975 VERYSYYTCDCDLTAFDGPYCNHDIGGF-FEPGTWMRYNLQSALRSAAREFS 1025
Score = 48.5 bits (114), Expect = 5e-05
Identities = 89/410 (21%), Positives = 142/410 (34%), Gaps = 82/410 (20%)
Query: 7 WRPTPPPLLLLLLLALAARADGLEFGGGPGQWARYARWAGAASSGELSFSLRTNATRALL 66
W P L L L +AD L F G R+ R + +FS +T LL
Sbjct: 153 WNPRGKIGLRLGLYGCPYKADILYFDGDDAISYRFPRGVSRSLWDVFAFSFKTEEKDGLL 212
Query: 67 LYLDDGGDCDFLELLLVDGRLRLRFTLSCA--EP----ATLQLDTPVADDRWHMVLLTRD 120
L+ + G D++ L L L L +L + +P T+ + D WH V + R
Sbjct: 213 LHAE-GAQGDYVTLELEGAHLLLHMSLGSSPIQPRPGHTTVSAGGVLNDQHWHYVRVDRF 271
Query: 121 ARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLSTVKYEPPFRGLLA 180
R +DG + + + + +++F+GG+ R + Y FRG +
Sbjct: 272 GRDVNFTLDGYVQRFILNGDFERLNLDTEMFIGGLVGAAR------KNLAYRHNFRGCIE 325
Query: 181 NLKLGERPPALLGSQGLRGATADPLCAPARNPCANGGLCTVLAPGEVGCDCSHTGFGGKF 240
N+ R AD A R+ S F GK
Sbjct: 326 NVIFN------------RVNIAD--LAVRRH--------------------SRITFEGKV 351
Query: 241 CSEEEHPMEGPAHLTLNSEGKEEFVATFKGNEFFCYDLSHNPIQSSTDEITLAFR--TLQ 298
P+ P +N G FV P + ++FR T
Sbjct: 352 AFRCLDPVPHP----INFGGPHNFVQV--------------PGFPRRGRLAVSFRFRTWD 393
Query: 299 RNGLMLHT--GKSADYVNLSLKSGAVWLVINLGSGAFEALVEPVNGKFNDNAWHDVRVTR 356
GL+L + G +V L+L G V +++ + L + ND WH+V
Sbjct: 394 LTGLLLFSRLGDGLGHVELTLSEGQV--NVSIAQSGRKKLQFAAGYRLNDGFWHEVNFV- 450
Query: 357 NLRQHAGIGHAMVTI-SVDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTA 405
A HA+++I V+G Y ++ + ++ GG P A
Sbjct: 451 -----AQENHAVISIDDVEGAEVRVSYP----LLIRTGTSYFFGGCPKPA 491
Score = 40.4 bits (93), Expect = 0.014
Identities = 29/79 (36%), Positives = 41/79 (51%), Gaps = 2/79 (2%)
Query: 52 ELSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDT-PVADD 110
E+SFS T++ A+LLY+ L+ DG L+LR+ L P QL T PV D
Sbjct: 1083 EVSFSFSTSSAPAVLLYVSSFVRDYMAVLIKDDGTLQLRYQLG-TSPYVYQLTTRPVTDG 1141
Query: 111 RWHMVLLTRDARRTALAVD 129
+ H + +TR R + VD
Sbjct: 1142 QPHSINITRVYRNLFIQVD 1160
>gi|18640734 contactin associated protein-like 5 [Homo sapiens]
Length = 1306
Score = 119 bits (298), Expect = 2e-26
Identities = 106/346 (30%), Positives = 167/346 (48%), Gaps = 44/346 (12%)
Query: 880 VTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSGNGNDFIVIELVK-GYIHYV 938
V+F + +SYL T A S + F FKTTA G+ L N G DFI +E+ I +
Sbjct: 793 VSFYTEASYLHFPTFHAEFSADISFFFKTTALSGVFLENLGI-KDFIRLEISSPSEITFA 851
Query: 939 FDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDS---RTVTQHSNGARNLDL 995
D+GNGP + S +NDNQWH V R+ +L++D+ T G L L
Sbjct: 852 IDVGNGPVELVVQSPSLLNDNQWHYVRAERNLKET-SLQVDNLPRSTRETSEEGHFRLQL 910
Query: 996 KGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDG 1055
+L++GG S + GF GC+ S+ LNG+ DL A G V GC G
Sbjct: 911 NSQLFVGGTSSR-----------QKGFLGCIRSLHLNGQKMDLEERAKVTSG-VRPGCPG 958
Query: 1056 PSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCN-------DPGT--TYIF----- 1101
++ C N G C+++ +G+ CDCT + Y GP C + GT TY+F
Sbjct: 959 HCSSYGS-ICHNGGKCVEKHNGYLCDCTNSPYEGPFCKKEVSAVFEAGTSVTYMFQEPYP 1017
Query: 1102 -GKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDY-LQLHIDQGT 1159
K +L + + PS + +A+ F T Q ++L+ ++S+S D+ + L G+
Sbjct: 1018 VTKNISLSSSAIYTDSAPS--KENIALSFVTTQAPSLLLFINSSS--QDFVVVLLCKNGS 1073
Query: 1160 VGVIFNVGTDD---ITIDEPNAIVSDGKYHVVRFTRSGGNATLQVD 1202
+ V +++ ++ TID N ++ + H ++ R G T+Q+D
Sbjct: 1074 LQVRYHLNKEETHVFTIDADN--FANRRMHHLKINREGRELTIQMD 1117
Score = 113 bits (282), Expect = 2e-24
Identities = 114/444 (25%), Positives = 196/444 (44%), Gaps = 54/444 (12%)
Query: 265 VATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLH-TGKSADYVNLSLKSGAVW 323
VA F G Y + + + D I+L F+++Q +G++ H G+ D++ L L+ G +
Sbjct: 180 VADFDGRSSLLYRFNQKLMSTLKDVISLKFKSMQGDGVLFHGEGQRGDHITLELQKGRLA 239
Query: 324 LVINLGSGAFE---ALVEPVNGKF-NDNAWHDVRVTRNLRQHAGIGHAMVTISVDGILTT 379
L +NLG +L G +D WH V + R +Q V +VD T
Sbjct: 240 LHLNLGDSKARLSSSLPSATLGSLLDDQHWHSVLIERVGKQ--------VNFTVDKH-TQ 290
Query: 380 TGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAK 439
T+ + L D GG P PG+ + NF GC++++ Y + + LAK
Sbjct: 291 HFRTKGETDALDIDYELSFGGIP-VPGKPGTFLKKNFHGCIENLYYNG----VNIIDLAK 345
Query: 440 EGDPKMKLQGDLSFRCEDVAALDPVTF-ESPEAFVALPRWSAKRTGSISLDFRTTEPNGL 498
++ G+++F C + + P+TF S +++ LP S+S FRT +GL
Sbjct: 346 RRKHQI-YTGNVTFSCSEPQIV-PITFVNSSGSYLLLPGTPQIDGLSVSFQFRTWNKDGL 403
Query: 499 LLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWC 558
LL ++ G+G+ + L G L L++ + + + +NDG W
Sbjct: 404 LLSTE---LSEGSGT---------LLLSLEGGILRLVIQKMTERVAEILTGSNLNDGLWH 451
Query: 559 HVDFQRDGRKGSISVNSRSTPFLATGDSEILDLES--ELYLGGLPEGGRVDLPLPPEVWT 616
V + +++++ + P DS + + S Y GG P+ L P
Sbjct: 452 SVSINARRNRITLTLDDEAAP--PAPDSTWVQIYSGNSYYFGGCPDNLTDSQCLNP---- 505
Query: 617 AALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGV-----APFCSRETLKQCASAPCRNG 671
++A + GC+R +FID + +DL ++ QG++G CS + +C C +G
Sbjct: 506 --IKA-FQGCMRLIFIDNQPKDL--ISVQQGSLGNFSDLHIDLCSIKD--RCLPNYCEHG 558
Query: 672 GVCREGWNRFICDCIGTGFLGRVC 695
G C + W F C+C T + G C
Sbjct: 559 GSCSQSWTTFYCNCSDTSYTGATC 582
Score = 112 bits (281), Expect = 2e-24
Identities = 103/418 (24%), Positives = 173/418 (41%), Gaps = 25/418 (5%)
Query: 695 CEREATVLSYDGSMYMKIMLPNAMHTEAEDV-SLRFMSQRAYGLMMATTSRESADTLRLE 753
C ++ V +DG + + + +DV SL+F S + G++ + D + LE
Sbjct: 174 CSYKSDVADFDGRSSLLYRFNQKLMSTLKDVISLKFKSMQGDGVLFHGEGQRG-DHITLE 232
Query: 754 LDGGQMKLTVNLGKGPETLFA-------GHKLNDNEWHTVRVVRRGKSLQLSVDNVTVEG 806
L G++ L +NLG L + G L+D WH+V + R GK + +VD T
Sbjct: 233 LQKGRLALHLNLGDSKARLSSSLPSATLGSLLDDQHWHSVLIERVGKQVNFTVDKHTQHF 292
Query: 807 QMAGAH--MRLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDGDITYC 864
+ G + +++ GI + + + NF G + L +NG +D K
Sbjct: 293 RTKGETDALDIDYELSFGGIPVPGKPGTFLKKNFHGCIENLYYNGVNIIDLAKRRKHQIY 352
Query: 865 ELNARFGLRAIVADPVTF-KSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNS-GNG 922
N F P+TF S SYL L + + FQF+T DGLLL G
Sbjct: 353 TGNVTFSCSEPQIVPITFVNSSGSYLLLPGTPQIDGLSVSFQFRTWNKDGLLLSTELSEG 412
Query: 923 NDFIVIELVKGYIHYVFD--LGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDS 980
+ +++ L G + V ++ G++ +ND WH+V ++ + TL +D
Sbjct: 413 SGTLLLSLEGGILRLVIQKMTERVAEILTGSN---LNDGLWHSVSINARRNRI-TLTLDD 468
Query: 981 RTVTQHSNGARNLDLKGE-LYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLI 1039
+ G Y GG N+ + + + FQGC+ + ++ + DLI
Sbjct: 469 EAAPPAPDSTWVQIYSGNSYYFGGCPDNLTDS--QCLNPIKAFQGCMRLIFIDNQPKDLI 526
Query: 1040 A---DALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCND 1094
+ +L + C C + G C Q W F C+C+ TSY G C++
Sbjct: 527 SVQQGSLGNFSDLHIDLCSIKDRCLPNYCEHGGSCSQSWTTFYCNCSDTSYTGATCHN 584
Score = 99.4 bits (246), Expect = 3e-20
Identities = 84/361 (23%), Positives = 170/361 (47%), Gaps = 60/361 (16%)
Query: 464 VTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYF 523
V+F + +++ P + A+ + IS F+TT +G+ L + G + D+
Sbjct: 793 VSFYTEASYLHFPTFHAEFSADISFFFKTTALSGVFLENLGIK--------------DFI 838
Query: 524 AMELLD-GHLYLLLDMGSGGIKLRASSRKV-NDGEWCHVDFQRDGRKGSISVNS--RSTP 579
+E+ + +D+G+G ++L S + ND +W +V +R+ ++ S+ V++ RST
Sbjct: 839 RLEISSPSEITFAIDVGNGPVELVVQSPSLLNDNQWHYVRAERNLKETSLQVDNLPRSTR 898
Query: 580 FLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDL 639
+ L L S+L++GG T++ + G++GC+R L ++G+ DL
Sbjct: 899 ETSEEGHFRLQLNSQLFVGG----------------TSSRQKGFLGCIRSLHLNGQKMDL 942
Query: 640 RGLAEAQGAVGVAPFCSRETLKQCAS--APCRNGGVCREGWNRFICDCIGTGFLGRVCER 697
A+ GV P C C+S + C NGG C E N ++CDC + + G C++
Sbjct: 943 EERAKVTS--GVRPGCPGH----CSSYGSICHNGGKCVEKHNGYLCDCTNSPYEGPFCKK 996
Query: 698 EATVLSYDGS----MYMK--------IMLPNAMHTEA----EDVSLRFMSQRAYGLMMAT 741
E + + G+ M+ + + +A++T++ E+++L F++ +A L++
Sbjct: 997 EVSAVFEAGTSVTYMFQEPYPVTKNISLSSSAIYTDSAPSKENIALSFVTTQAPSLLLFI 1056
Query: 742 TSRESADTLRLELDGGQMKLTVNLGKGPETLFA--GHKLNDNEWHTVRVVRRGKSLQLSV 799
S + L G +++ +L K +F + H +++ R G+ L + +
Sbjct: 1057 NSSSQDFVVVLLCKNGSLQVRYHLNKEETHVFTIDADNFANRRMHHLKINREGRELTIQM 1116
Query: 800 D 800
D
Sbjct: 1117 D 1117
Score = 60.8 bits (146), Expect = 1e-08
Identities = 91/379 (24%), Positives = 155/379 (40%), Gaps = 72/379 (18%)
Query: 719 HTE-AEDVSLRFMSQRAYGLMMATTSRESADTLRLELDG-GQMKLTVNLGKGPETLFAGH 776
H E + D+S F + G+ + + D +RLE+ ++ +++G GP L
Sbjct: 808 HAEFSADISFFFKTTALSGVFLENLGIK--DFIRLEISSPSEITFAIDVGNGPVELVVQS 865
Query: 777 K--LNDNEWHTVRVVRRGKSLQLSVDNV---TVEGQMAGAHMRLEFHN-IETGIMTERRF 830
LNDN+WH VR R K L VDN+ T E G H RL+ ++ + G + R+
Sbjct: 866 PSLLNDNQWHYVRAERNLKETSLQVDNLPRSTRETSEEG-HFRLQLNSQLFVGGTSSRQ- 923
Query: 831 ISVVPSNFIGHLSGLVFNGQ-----------------------PYMDQCKDG-------- 859
F+G + L NGQ Y C +G
Sbjct: 924 -----KGFLGCIRSLHLNGQKMDLEERAKVTSGVRPGCPGHCSSYGSICHNGGKCVEKHN 978
Query: 860 ----DIT-------YC--ELNARFGLRAIVA------DPVTFKSRSSYLALATLQAYASM 900
D T +C E++A F V PVT S A+ T A +
Sbjct: 979 GYLCDCTNSPYEGPFCKKEVSAVFEAGTSVTYMFQEPYPVTKNISLSSSAIYTDSAPSKE 1038
Query: 901 HLFFQFKTTAPDGLLLFNSGNGNDFIVIELVK-GYIHYVFDLGNGPSLMKGNSDKPVNDN 959
++ F TT LLLF + + DF+V+ L K G + + L + + +
Sbjct: 1039 NIALSFVTTQAPSLLLFINSSSQDFVVVLLCKNGSLQVRYHLNKEETHVFTIDADNFANR 1098
Query: 960 QWHNVVVSRDPGNVHTLKIDSRTVTQHSNGARNLDLK--GELYIGGLSKNMFSNLPKLVA 1017
+ H++ ++R+ G T+++D + + N + ++ + L +G +++N+ + A
Sbjct: 1099 RMHHLKINRE-GRELTIQMDQQLRLSY-NFSPEVEFRVIRSLTLGKVTENLGLDSEVAKA 1156
Query: 1018 SRDGFQGCLASVDLNGRLP 1036
+ GF GC++SV N P
Sbjct: 1157 NAMGFAGCMSSVQYNHIAP 1175
Score = 60.1 bits (144), Expect = 2e-08
Identities = 78/325 (24%), Positives = 138/325 (42%), Gaps = 33/325 (10%)
Query: 47 AASSGELSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAE-PATLQLDT 105
A S ++SF +T A + +L++ G DF+ L + + F + P L + +
Sbjct: 809 AEFSADISFFFKTTALSGV--FLENLGIKDFIRLE-ISSPSEITFAIDVGNGPVELVVQS 865
Query: 106 P--VADDRWHMVLLTRDARRTALAVDGEARAAEVRSKRR--EMQVASDLFVGGIPPDVRL 161
P + D++WH V R+ + T+L VD R+ S+ +Q+ S LFVGG
Sbjct: 866 PSLLNDNQWHYVRAERNLKETSLQVDNLPRSTRETSEEGHFRLQLNSQLFVGG------- 918
Query: 162 SALTLSTVKYEPPFRGLLANLKLGERPPAL----LGSQGLRGATADPLCAPARNPCANGG 217
T + F G + +L L + L + G+R C+ + C NGG
Sbjct: 919 ------TSSRQKGFLGCIRSLHLNGQKMDLEERAKVTSGVRPGCPGH-CSSYGSICHNGG 971
Query: 218 LCTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEGKEEFVATFKGNEFFCYD 277
C G + CDC+++ + G FC +E + A ++ +E + T N
Sbjct: 972 KCVEKHNGYL-CDCTNSPYEGPFCKKEVSAV-FEAGTSVTYMFQEPYPVT--KNISLSSS 1027
Query: 278 LSHNPIQSSTDEITLAFRTLQRNGLMLHTGKSA-DYVNLSL-KSGAVWLVINLGSGAFEA 335
+ S + I L+F T Q L+L S+ D+V + L K+G++ + +L
Sbjct: 1028 AIYTDSAPSKENIALSFVTTQAPSLLLFINSSSQDFVVVLLCKNGSLQVRYHLNKEETHV 1087
Query: 336 LVEPVNGKFNDNAWHDVRVTRNLRQ 360
+ F + H +++ R R+
Sbjct: 1088 FTIDAD-NFANRRMHHLKINREGRE 1111
Score = 52.0 bits (123), Expect = 5e-06
Identities = 40/153 (26%), Positives = 74/153 (48%), Gaps = 21/153 (13%)
Query: 289 EITLAFRTLQRNGLMLHTGKSADYVNLSLKSGA-VWLVINLGSGAFEALVEPVNGKFNDN 347
+I+ F+T +G+ L D++ L + S + + I++G+G E +V+ + NDN
Sbjct: 814 DISFFFKTTALSGVFLENLGIKDFIRLEISSPSEITFAIDVGNGPVELVVQSPS-LLNDN 872
Query: 348 AWHDVRVTRNLRQHAGIGHAMVTISVDGILTTTGYTQED-YTMLGSDDFFYIGGSPNTAD 406
WH VR RNL++ ++ VD + +T T E+ + L + ++GG+
Sbjct: 873 QWHYVRAERNLKE--------TSLQVDNLPRSTRETSEEGHFRLQLNSQLFVGGT----- 919
Query: 407 LPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAK 439
S F+GC++ + N K++L AK
Sbjct: 920 ---SSRQKGFLGCIRSL--HLNGQKMDLEERAK 947
Score = 46.2 bits (108), Expect = 3e-04
Identities = 52/199 (26%), Positives = 78/199 (39%), Gaps = 17/199 (8%)
Query: 53 LSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDRW 112
+SF RT LLL + L L L G LRL A + + + D W
Sbjct: 391 VSFQFRTWNKDGLLLSTELSEGSGTLLLSLEGGILRLVIQKMTERVAEILTGSNLNDGLW 450
Query: 113 HMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLSTVKYE 172
H V + R L +D EA S ++ + + GG PD + L+ +K
Sbjct: 451 HSVSINARRNRITLTLDDEAAPPAPDSTWVQIYSGNSYYFGGC-PDNLTDSQCLNPIK-- 507
Query: 173 PPFRGLLANLKLGERPPALLG-SQGLRGATAD---------PLCAPARNPCANGGLCTVL 222
F+G + + + +P L+ QG G +D C P N C +GG C+
Sbjct: 508 -AFQGCMRLIFIDNQPKDLISVQQGSLGNFSDLHIDLCSIKDRCLP--NYCEHGGSCS-Q 563
Query: 223 APGEVGCDCSHTGFGGKFC 241
+ C+CS T + G C
Sbjct: 564 SWTTFYCNCSDTSYTGATC 582
Score = 39.3 bits (90), Expect = 0.032
Identities = 36/159 (22%), Positives = 64/159 (40%), Gaps = 18/159 (11%)
Query: 1119 STRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDE--P 1176
ST D +++ F + Q VL + G D++ L + +G + + N+G + P
Sbjct: 199 STLKDVISLKFKSMQGDGVLFHGEGQRG--DHITLELQKGRLALHLNLGDSKARLSSSLP 256
Query: 1177 NA----IVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGRQLTIFNSQAAIKIGGRD- 1231
+A ++ D +H V R G VD + + + + + GG
Sbjct: 257 SATLGSLLDDQHWHSVLIERVGKQVNFTVDKH--TQHFRTKGETDALDIDYELSFGGIPV 314
Query: 1232 QGRP-------FQGQVSGLYYNGLKVLALAAESDPNVRT 1263
G+P F G + LYYNG+ ++ LA + T
Sbjct: 315 PGKPGTFLKKNFHGCIENLYYNGVNIIDLAKRRKHQIYT 353
Score = 37.7 bits (86), Expect = 0.092
Identities = 34/157 (21%), Positives = 63/157 (40%), Gaps = 9/157 (5%)
Query: 7 WRPTPPPLLLLLLLALAARADGLEFGGGPGQWARYARWAGAASSGELSFSLRTNATRALL 66
W P+ + + + + ++D +F G R+ + + +S ++ +L
Sbjct: 159 WNPSGKIGMRVEVYGCSYKSDVADFDGRSSLLYRFNQKLMSTLKDVISLKFKSMQGDGVL 218
Query: 67 LYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVA-------DDRWHMVLLTR 119
+ +G D + L L GRL L L ++ A L P A D WH VL+ R
Sbjct: 219 FH-GEGQRGDHITLELQKGRLALHLNLGDSK-ARLSSSLPSATLGSLLDDQHWHSVLIER 276
Query: 120 DARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIP 156
++ VD + + + + + +L GGIP
Sbjct: 277 VGKQVNFTVDKHTQHFRTKGETDALDIDYELSFGGIP 313
Score = 37.0 bits (84), Expect = 0.16
Identities = 29/110 (26%), Positives = 52/110 (47%), Gaps = 7/110 (6%)
Query: 1146 GLGDYLQLHIDQG---TVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVD 1202
G+ D+++L I T + G ++ + P+ +++D ++H VR R+ +LQVD
Sbjct: 833 GIKDFIRLEISSPSEITFAIDVGNGPVELVVQSPS-LLNDNQWHYVRAERNLKETSLQVD 891
Query: 1203 SWP--VNERYPAGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLKV 1250
+ P E G NSQ + G + + F G + L+ NG K+
Sbjct: 892 NLPRSTRETSEEGHFRLQLNSQLFVG-GTSSRQKGFLGCIRSLHLNGQKM 940
>gi|148664242 cell recognition protein CASPR4 isoform 2 [Homo sapiens]
Length = 1235
Score = 116 bits (291), Expect = 2e-25
Identities = 99/343 (28%), Positives = 159/343 (46%), Gaps = 39/343 (11%)
Query: 881 TFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSGNGNDFIVIELVKG-YIHYVF 939
+F + +SYL T S + F FKTTA G+ L N G DFI IEL + + F
Sbjct: 723 SFDTEASYLHFPTFHGELSADVSFFFKTTASSGVFLENLGIA-DFIRIELRSPTVVTFSF 781
Query: 940 DLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDS---RTVTQHSNGARNLDLK 996
D+GNGP + S NDNQWH+V V R+ +L++D +T ++G L L
Sbjct: 782 DVGNGPFEISVQSPTHFNDNQWHHVRVERNMKEA-SLQVDQLTPKTQPAPADGHVLLQLN 840
Query: 997 GELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGP 1056
+L++GG + + GF GC+ S+ LNG DL + +V+ GC G
Sbjct: 841 SQLFVGGTATR-----------QRGFLGCIRSLQLNGMTLDL-EERAQVTPEVQPGCRGH 888
Query: 1057 STTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALI-----TYT 1111
++ + C N G C ++ GF CDCT ++Y GP C++ + Y FG G ++I Y
Sbjct: 889 CSSYGK-LCRNGGKCRERPIGFFCDCTFSAYTGPFCSNEISAY-FGSGSSVIYNFQENYL 946
Query: 1112 WPPND-------RPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHI-DQGTVGVI 1163
N ++ R + FS + + +S +YL + I G++ +
Sbjct: 947 LSKNSSSHAASFHGDMKLSREMIKFSFRTTRTPSLLLFVSSFYKEYLSVIIAKNGSLQIR 1006
Query: 1164 FNVG----TDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVD 1202
+ + D + D N ++DG+ H + R G +++D
Sbjct: 1007 YKLNKYQEPDVVNFDFKN--MADGQLHHIMINREEGVVFIEID 1047
Score = 109 bits (272), Expect = 2e-23
Identities = 105/423 (24%), Positives = 163/423 (38%), Gaps = 83/423 (19%)
Query: 695 CEREATVLSYDGSMYMKIMLPNAMHTEAEDV-SLRFMSQRAYGLMMATTSRESADTLRLE 753
C + V+ DG + + +D+ SL+F + ++ G+++ + D + L+
Sbjct: 152 CAYRSEVVDLDGKSSLLYRFDQKSLSPIKDIISLKFKTMQSDGILLHREG-PNGDHITLQ 210
Query: 754 LDGGQMKLTVNLGKG--PET-----LFAGHKLNDNEWHTVRVVRRGKSLQLSVDNVTVEG 806
L ++ L +N G+ P T L G L+D WH+V + R GK + N TV+
Sbjct: 211 LRRARLFLLINSGEAKLPSTSTLVNLTLGSLLDDQHWHSVLIQRLGKQV-----NFTVDE 265
Query: 807 QMAGAHMRLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDGDITYCEL 866
H R EF+ L L + G
Sbjct: 266 HRHHFHARGEFN-----------------------LMNLDYEG----------------- 285
Query: 867 NARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSGNGNDFI 926
N F + PVTF S SYLAL + FQF+T GLLLF+
Sbjct: 286 NVSFSCSQPQSMPVTFLSSRSYLALPDFSGEEEVSATFQFRTWNKAGLLLFSE------- 338
Query: 927 VIELVKGYIHYVFDLGNGPSLMKGNSDKP------------VNDNQWHNVVVSRDPGNVH 974
++L+ G I G +K N +P +ND QWH+V +S ++
Sbjct: 339 -LQLISGGILLFLSDGK----LKSNLYQPGKLPSDITAGVELNDGQWHSVSLSAKKNHLS 393
Query: 975 TLKIDSRTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGR 1034
G + G Y GG F + K + GFQGC+ + ++G+
Sbjct: 394 VAVDGQMASAAPLLGPEQIYSGGTYYFGGCPDKSFGS--KCKSPLGGFQGCMRLISISGK 451
Query: 1035 LPDLIA---DALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPV 1091
+ DLI+ +L ++ G S C C + G C Q W F C+CT T Y G
Sbjct: 452 VVDLISVQQGSLGNFSDLQIDSCGISDRCLPNYCEHGGECSQSWSTFHCNCTNTGYRGAT 511
Query: 1092 CND 1094
C++
Sbjct: 512 CHN 514
Score = 103 bits (258), Expect = 1e-21
Identities = 180/819 (21%), Positives = 310/819 (37%), Gaps = 163/819 (19%)
Query: 54 SFSLRTNATRALLLY----LDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVAD 109
+F RT LLL+ L GG + L L DG+L+ P+ + + D
Sbjct: 322 TFQFRTWNKAGLLLFSELQLISGG----ILLFLSDGKLKSNLYQPGKLPSDITAGVELND 377
Query: 110 DRWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLSTV 169
+WH V L+ ++AVDG+ +A ++ + GG P D + S +
Sbjct: 378 GQWHSVSLSAKKNHLSVAVDGQMASAAPLLGPEQIYSGGTYYFGGCP-DKSFGSKCKSPL 436
Query: 170 KYEPPFRGLLANLKLGERPPALLG-SQGLRGATAD---------PLCAPARNPCANGGLC 219
F+G + + + + L+ QG G +D C P N C +GG C
Sbjct: 437 G---GFQGCMRLISISGKVVDLISVQQGSLGNFSDLQIDSCGISDRCLP--NYCEHGGEC 491
Query: 220 TVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEGKEEFVATFKGNEFFCYDLS 279
+ + C+C++TG+ G C H ++ + E + + F+ D
Sbjct: 492 SQ-SWSTFHCNCTNTGYRGATC-----------HNSIYEQSCEAYKHRGNTSGFYYIDSD 539
Query: 280 HN----PIQSSTDEITLAFRTLQRNGLMLHTGKSADYVNLSLKSGAVWLVINLGSGAFE- 334
+ P + A+ +Q NG L ++ + N +G FE
Sbjct: 540 GSGPLEPFLLYCNMTETAWTIIQHNGSDLTRVRNTNPENPY-------------AGFFEY 586
Query: 335 -ALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVTISVDGILTT--TGYTQEDYTMLG 391
A +E + N + T ++ + + DG + G T E T G
Sbjct: 587 VASMEQLQATINRAEHCEQEFTYYCKK------SRLVNKQDGTPLSWWVGRTNETQTYWG 640
Query: 392 SDDFFYIGGSPN----TADLPGSPV-SNNFMGCLKDVVYKNNDFKL-------------- 432
G SP+ T L G+ + S + C D ND L
Sbjct: 641 -------GSSPDLQKCTCGLEGNCIDSQYYCNCDADRNEWTNDTGLLAYKEHLPVTKIVI 693
Query: 433 -ELSRLAKEGDPKMK---LQGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISL 488
+ RL E K+ QGD SF + +F++ +++ P + + + +S
Sbjct: 694 TDTGRLHSEAAYKLGPLLCQGDRSF-------WNSASFDTEASYLHFPTFHGELSADVSF 746
Query: 489 DFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLL-LDMGSGGIKLRA 547
F+TT +G+ L + G AD+ +EL + D+G+G ++
Sbjct: 747 FFKTTASSGVFLENLGI--------------ADFIRIELRSPTVVTFSFDVGNGPFEISV 792
Query: 548 SS-RKVNDGEWCHVDFQRDGRKGSISVNS---RSTPFLATGDSEILDLESELYLGGLPEG 603
S ND +W HV +R+ ++ S+ V+ ++ P A G +L L S+L++GG
Sbjct: 793 QSPTHFNDNQWHHVRVERNMKEASLQVDQLTPKTQPAPADGHV-LLQLNSQLFVGG---- 847
Query: 604 GRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQC 663
TA + G++GC+R L ++G + DL AQ V P C C
Sbjct: 848 ------------TATRQRGFLGCIRSLQLNGMTLDLE--ERAQVTPEVQPGCRGH----C 889
Query: 664 ASAP--CRNGGVCREGWNRFICDCIGTGFLGRVCEREATVLSYDGSMYMKIMLPN----- 716
+S CRNGG CRE F CDC + + G C E + GS + N
Sbjct: 890 SSYGKLCRNGGKCRERPIGFFCDCTFSAYTGPFCSNEISAYFGSGSSVIYNFQENYLLSK 949
Query: 717 -----------AMHTEAEDVSLRFMSQRAYGLMMATTS--RESADTLRLELDGGQMKLTV 763
M E + F + R L++ +S +E + + Q++ +
Sbjct: 950 NSSSHAASFHGDMKLSREMIKFSFRTTRTPSLLLFVSSFYKEYLSVIIAKNGSLQIRYKL 1009
Query: 764 NLGKGPETL-FAGHKLNDNEWHTVRVVRRGKSLQLSVDN 801
N + P+ + F + D + H + + R + + +D+
Sbjct: 1010 NKYQEPDVVNFDFKNMADGQLHHIMINREEGVVFIEIDD 1048
Score = 87.0 bits (214), Expect = 1e-16
Identities = 69/254 (27%), Positives = 110/254 (43%), Gaps = 31/254 (12%)
Query: 448 QGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRA 507
+G++SF C ++ PVTF S +++ALP +S + S + FRT GLLLFS+ +
Sbjct: 284 EGNVSFSCSQPQSM-PVTFLSSRSYLALPDFSGEEEVSATFQFRTWNKAGLLLFSELQLI 342
Query: 508 GGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGR 567
GG + L DG L L + ++NDG+W V
Sbjct: 343 SGG------------ILLFLSDGKLKSNLYQPGKLPSDITAGVELNDGQWHSVSLSAKKN 390
Query: 568 KGSISVNSRSTPFLATGDSEILDLESELYLGGLPE---GGRVDLPLPPEVWTAALRAGYV 624
S++V+ + E + Y GG P+ G + PL G+
Sbjct: 391 HLSVAVDGQMASAAPLLGPEQIYSGGTYYFGGCPDKSFGSKCKSPL----------GGFQ 440
Query: 625 GCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETL---KQCASAPCRNGGVCREGWNRF 681
GC+R + I G+ DL ++ QG++G ++ +C C +GG C + W+ F
Sbjct: 441 GCMRLISISGKVVDL--ISVQQGSLGNFSDLQIDSCGISDRCLPNYCEHGGECSQSWSTF 498
Query: 682 ICDCIGTGFLGRVC 695
C+C TG+ G C
Sbjct: 499 HCNCTNTGYRGATC 512
Score = 71.2 bits (173), Expect = 8e-12
Identities = 95/382 (24%), Positives = 153/382 (40%), Gaps = 74/382 (19%)
Query: 724 DVSLRFMSQRAYGLMMATTSRESADTLRLELDGGQM-KLTVNLGKGPETLFAGHK--LND 780
DVS F + + G+ + AD +R+EL + + ++G GP + ND
Sbjct: 743 DVSFFFKTTASSGVFLENLG--IADFIRIELRSPTVVTFSFDVGNGPFEISVQSPTHFND 800
Query: 781 NEWHTVRVVRRGKSLQLSVDNVTVEGQMAGA--HMRLEFHN--IETGIMTERRFISVVPS 836
N+WH VRV R K L VD +T + Q A A H+ L+ ++ G T +R
Sbjct: 801 NQWHHVRVERNMKEASLQVDQLTPKTQPAPADGHVLLQLNSQLFVGGTATRQR------- 853
Query: 837 NFIGHLSGLVFNG---------------QP--------YMDQCKDG------------DI 861
F+G + L NG QP Y C++G D
Sbjct: 854 GFLGCIRSLQLNGMTLDLEERAQVTPEVQPGCRGHCSSYGKLCRNGGKCRERPIGFFCDC 913
Query: 862 TYCELNARFGLRAIVA-----DPVTFKSRSSYLALATLQAYA-SMH---------LFFQF 906
T+ F I A V + + +YL ++A S H + F F
Sbjct: 914 TFSAYTGPFCSNEISAYFGSGSSVIYNFQENYLLSKNSSSHAASFHGDMKLSREMIKFSF 973
Query: 907 KTTAPDGLLLFNSGNGNDFIVIELVKG---YIHYVFDLGNGPSLMKGNSD-KPVNDNQWH 962
+TT LLLF S +++ + + K I Y + P ++ N D K + D Q H
Sbjct: 974 RTTRTPSLLLFVSSFYKEYLSVIIAKNGSLQIRYKLNKYQEPDVV--NFDFKNMADGQLH 1031
Query: 963 NVVVSRDPGNVHTLKIDSRTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGF 1022
+++++R+ G V D+R H + L +G + ++ + +A GF
Sbjct: 1032 HIMINREEGVVFIEIDDNRRRQVHLSSGTEFSAVKSLVLGRILEHSDVDQDTALAGAQGF 1091
Query: 1023 QGCLASVDLNGRLPDLIADALH 1044
GCL++V L+ P + ALH
Sbjct: 1092 TGCLSAVQLSHVAP--LKAALH 1111
Score = 51.2 bits (121), Expect = 8e-06
Identities = 63/268 (23%), Positives = 108/268 (40%), Gaps = 38/268 (14%)
Query: 50 SGELSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAE---PATLQLDTP 106
S ++SF +T A+ + +L++ G DF+ + L + + F+ ++Q T
Sbjct: 741 SADVSFFFKTTASSGV--FLENLGIADFIRIELRSPTV-VTFSFDVGNGPFEISVQSPTH 797
Query: 107 VADDRWHMVLLTRDARRTALAVDGEARAAEVRSKRRE--MQVASDLFVGGIPPDVRLSAL 164
D++WH V + R+ + +L VD + +Q+ S LFVGG
Sbjct: 798 FNDNQWHHVRVERNMKEASLQVDQLTPKTQPAPADGHVLLQLNSQLFVGG---------- 847
Query: 165 TLSTVKYEPPFRGLLANLKLG-------ERPPALLGSQ-GLRGATADPLCAPARNPCANG 216
T + F G + +L+L ER Q G RG C+ C NG
Sbjct: 848 ---TATRQRGFLGCIRSLQLNGMTLDLEERAQVTPEVQPGCRGH-----CSSYGKLCRNG 899
Query: 217 GLCTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEGKEEFVATFKGNEFFCY 276
G C G CDC+ + + G FCS E G + + + ++ + +
Sbjct: 900 GKCRERPIGFF-CDCTFSAYTGPFCSNEISAYFGSGSSVIYNFQENYLLSKNSSSHAASF 958
Query: 277 DLSHNPIQSSTDEITLAFRTLQRNGLML 304
H ++ S + I +FRT + L+L
Sbjct: 959 ---HGDMKLSREMIKFSFRTTRTPSLLL 983
Score = 47.4 bits (111), Expect = 1e-04
Identities = 27/97 (27%), Positives = 44/97 (45%), Gaps = 5/97 (5%)
Query: 265 VATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLH-TGKSADYVNLSLKSGAVW 323
V G Y + D I+L F+T+Q +G++LH G + D++ L L+ ++
Sbjct: 158 VVDLDGKSSLLYRFDQKSLSPIKDIISLKFKTMQSDGILLHREGPNGDHITLQLRRARLF 217
Query: 324 LVINLGSGAFEALVEPVN----GKFNDNAWHDVRVTR 356
L+IN G + VN +D WH V + R
Sbjct: 218 LLINSGEAKLPSTSTLVNLTLGSLLDDQHWHSVLIQR 254
Score = 42.7 bits (99), Expect = 0.003
Identities = 33/117 (28%), Positives = 55/117 (47%), Gaps = 23/117 (19%)
Query: 486 ISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKL 545
ISL F+T + +G+LL H D+ ++L L+LL++ SG KL
Sbjct: 183 ISLKFKTMQSDGILL-------------HREGPNGDHITLQLRRARLFLLIN--SGEAKL 227
Query: 546 RASSRKVN--------DGEWCHVDFQRDGRKGSISVNSRSTPFLATGDSEILDLESE 594
++S VN D W V QR G++ + +V+ F A G+ +++L+ E
Sbjct: 228 PSTSTLVNLTLGSLLDDQHWHSVLIQRLGKQVNFTVDEHRHHFHARGEFNLMNLDYE 284
>gi|33469931 EGF-like, fibronectin type III and laminin G domains
isoform 2 [Homo sapiens]
Length = 775
Score = 114 bits (286), Expect = 6e-25
Identities = 141/629 (22%), Positives = 254/629 (40%), Gaps = 118/629 (18%)
Query: 229 CDCSHTGFGGKFCSEE---EHPMEGPAHLTLNSEGKEEFVATFKGNEFFCYDLSHNPIQS 285
C C+ G GG+ CSE+ ++P F G+ + ++ N Q+
Sbjct: 135 CQCT-LGKGGESCSEDIVIQYPQ-------------------FFGHSYVTFEPLKNSYQA 174
Query: 286 STDEITLAFRTLQRNGLMLHTGKS----ADYVNLSLKSGAVWLVINLGSGAFEALVEPVN 341
+ITL FR +GL+L+ G++ D+++L++ ++ N G+G + E
Sbjct: 175 F--QITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSET-- 230
Query: 342 GKFNDNAWHDVRVTRNLRQHAGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYIGGS 401
K WH V + R+ G+ + ++ TG +Q Y+ + Y+GG+
Sbjct: 231 -KIKLGGWHTVMLYRD-----GLNGLL---QLNNGTPVTGQSQGQYSKITFRTPLYLGGA 281
Query: 402 PNTADLPGSPVSNN-FMGCLKDVVYKNNDFKLELSRLAK--------------------- 439
P+ L + +N F GC++ + + L K
Sbjct: 282 PSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCI 341
Query: 440 EGDPKMKLQGD-------LSFR---CEDVAALDPVTF-ESPEAFVALPRWSAKRTGSIS- 487
G ++ D L F+ CED L F ES ++ A P W + +S
Sbjct: 342 HGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATP-WPLEPQHYLSF 400
Query: 488 ----LDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGI 543
+ FR +G+LL+S GS D+ ++ L GH+ D GSG
Sbjct: 401 MEFEITFRPDSGDGVLLYSYD------TGSK------DFLSINLAGGHVEFRFDCGSGTG 448
Query: 544 KLRASSRKVNDGEWCHVDFQRDGRKGSISVNSRS-TPFLATGDSEILDLESELYLGGLPE 602
LR S + G W + R + G + V+ + +A G + +++++GG+P
Sbjct: 449 VLR-SEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPN 507
Query: 603 GGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQ 662
V + + + G ++ + ++ R+ ++ + V V
Sbjct: 508 YDDVKK-------NSGVLKPFSGSIQKIILNDRTIHVKH--DFTSGVNV-----ENAAHP 553
Query: 663 CASAPCRNGGVCREGWNRFICDCIGTGFLGRVCEREAT----VLSYDGSMYMKIMLPNAM 718
C APC +GG CR + CDC GF G C++ + + G Y+ P+ +
Sbjct: 554 CVRAPCAHGGSCRPRKEGYDCDC-PLGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDIL 612
Query: 719 HTEA---EDVSLRFMSQRAYGLMM---ATTSRESADTLRLELDGGQMKLTVNLGKGPETL 772
+ +V +RF + GL++ + R ++D + L L G + + NLG G ++
Sbjct: 613 KRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASI 672
Query: 773 FAGHKLNDNEWHTVRVVRRGKSLQLSVDN 801
ND WH V+ VR G+S +++VD+
Sbjct: 673 MVNGSFNDGRWHRVKAVRDGQSGKITVDD 701
Score = 110 bits (274), Expect = 1e-23
Identities = 108/406 (26%), Positives = 171/406 (42%), Gaps = 57/406 (14%)
Query: 52 ELSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDR 111
E + R ++ +LLY D G DFL + L G + RF + L+ + P+
Sbjct: 402 EFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCG-SGTGVLRSEDPLTLGN 460
Query: 112 WHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVA--SDLFVGGIP--PDVRLSALTLS 167
WH + ++R A+ L VD + + E ++ Q+ +D+F+GG+P DV+ ++ L
Sbjct: 461 WHELRVSRTAKNGILQVD-KQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLK 519
Query: 168 TVKYEPPFRGLLANLKLGERPPALLG--SQGLRGATADPLCAPARNPCANGGLCTVLAPG 225
PF G + + L +R + + G+ A C R PCA+GG C G
Sbjct: 520 ------PFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPC--VRAPCAHGGSCRPRKEG 571
Query: 226 EVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEGKEEFVATFKGNEFFCYDLSHNP--- 282
CDC GF G C + E E + F G + YD NP
Sbjct: 572 -YDCDCP-LGFEGLHCQK------------AIIEAIE--IPQFIGRSYLTYD---NPDIL 612
Query: 283 --IQSSTDEITLAFRTLQRNGLMLHTGKS-----ADYVNLSLKSGAVWLVINLGSGAFEA 335
+ S + + F+T ++GL+L G S +D+++L L+ GA+ NLGSG
Sbjct: 613 KRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASI 672
Query: 336 LVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDF 395
+ VNG FND WH V+ R+ + I+VD TG + L +
Sbjct: 673 M---VNGSFNDGRWHRVKAVRDGQSG--------KITVDDYGARTGKSPGMMRQLNINGA 721
Query: 396 FYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEG 441
Y+GG A +GC+ + D+ + L A +G
Sbjct: 722 LYVGGMKEIALHTNRQYMRGLVGCISHFTL-STDYHISLVEDAVDG 766
Score = 108 bits (269), Expect = 6e-23
Identities = 153/651 (23%), Positives = 259/651 (39%), Gaps = 84/651 (12%)
Query: 644 EAQGAVGVAPFCSRETLKQCASAPCRNGGVCREG--WNRFICDC-IGTGFLGRVCEREAT 700
+ +G GVA SR C C C W C C +G G G C +
Sbjct: 95 QRKGKNGVA-IMSRLFDMPCDETLCSADSFCVNDYTWGGSRCQCTLGKG--GESCSEDIV 151
Query: 701 VL--SYDGSMYMKIMLPNAMHTEAEDVSLRFMSQRAYGLMMATTSRESA--DTLRLELDG 756
+ + G Y+ P +A ++L F ++ GL++ E D + L +
Sbjct: 152 IQYPQFFGHSYVTFE-PLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIR 210
Query: 757 GQMKLTVNLGKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDNVT-VEGQMAGAHMRL 815
++ N G G + + K+ WHTV + R G + L ++N T V GQ G + ++
Sbjct: 211 RSLQFRFNCGTGVAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKI 270
Query: 816 EFHN--IETGIMTERRFISVVPSN--FIGHLSGLVFNGQ-------PYMDQCKDGDITYC 864
F G + + +N F G + L NG+ P D+ C
Sbjct: 271 TFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGEC 330
Query: 865 ------ELNARFG--LRAIVAD------PVTFKSRSSYLALA--------TLQAYAS--- 899
E + G AI AD P+ FK R A +L++YA+
Sbjct: 331 SSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPW 390
Query: 900 ----------MHLFFQFKTTAPDGLLLFNSGNGN-DFIVIELVKGYIHYVFDLGNGPSLM 948
M F+ + DG+LL++ G+ DF+ I L G++ + FD G+G ++
Sbjct: 391 PLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVL 450
Query: 949 KGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQH--SNGARNLDLKGELYIGGLSK 1006
+ S+ P+ WH + VSR N L++D + + + G + +++IGG+
Sbjct: 451 R--SEDPLTLGNWHELRVSRTAKN-GILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPN 507
Query: 1007 NMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPSTTCTEESCA 1066
+ ++ K F G + + LN R + D + + + C CA
Sbjct: 508 --YDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVN-----VENAAHPCVRAPCA 560
Query: 1067 NQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYIFGK---GGALITYTWPP-NDRPSTRM 1122
+ G C + +G+ CDC + + G C I G + +TY P R S
Sbjct: 561 HGGSCRPRKEGYDCDCPL-GFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSR 619
Query: 1123 DRLAVGFSTHQRSAVLV-RVDS-ASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEPNAIV 1180
+ + F T + +L+ R DS D++ L + G + +N+G+ +I N
Sbjct: 620 SNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASI-MVNGSF 678
Query: 1181 SDGKYHVVRFTRSGGNATLQVDSWPVNERYPAG--RQLTIFNSQAAIKIGG 1229
+DG++H V+ R G + + VD + G RQL N A+ +GG
Sbjct: 679 NDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQL---NINGALYVGG 726
Score = 102 bits (255), Expect = 2e-21
Identities = 143/603 (23%), Positives = 249/603 (41%), Gaps = 101/603 (16%)
Query: 52 ELSFSLRTNATRALLLYLDDG--GDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVAD 109
+++ R A LLLY + G DF+ L ++ L+ RF A + +T +
Sbjct: 176 QITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGV-AIIVSETKIKL 234
Query: 110 DRWHMVLLTRDARRTALAVD-GEARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLST 168
WH V+L RD L ++ G + + + ++ + L++GG P L T +
Sbjct: 235 GGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTN 294
Query: 169 VKYEPPFRGLLANLKLGERPPALLGSQGLRGAT----ADPLCAPARNPCANGGLCTVLAP 224
++ + L N + + P LG + L GA + +C A C +GG CT +
Sbjct: 295 RGFQGCVQSLAVNGRRIDMRPWPLG-KALSGADVGECSSGICDEAS--CIHGGTCTAIKA 351
Query: 225 GEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEGKEEFVATFKGNEFFCYDLSHNPIQ 284
C C GF G+ C + TL E + ++ + P++
Sbjct: 352 DSYICLCP-LGFKGRHCEDA---------FTLTIPQFRESLRSYAATPW--------PLE 393
Query: 285 S----STDEITLAFRTLQRNGLMLH---TGKSADYVNLSLKSGAVWLVINLGSGAFEALV 337
S E + FR +G++L+ TG S D+++++L G V + GSG
Sbjct: 394 PQHYLSFMEFEITFRPDSGDGVLLYSYDTG-SKDFLSINLAGGHVEFRFDCGSGTGVLRS 452
Query: 338 EPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFY 397
E N WH++RV+R + GI + VD G + +T + + +
Sbjct: 453 EDPLTLGN---WHELRVSRTAKN--GI------LQVDKQKIVEGMAEGGFTQIKCNTDIF 501
Query: 398 IGGSPNTADL-PGSPVSNNFMGCLKDV------VYKNNDFKLELS--------------- 435
IGG PN D+ S V F G ++ + ++ +DF ++
Sbjct: 502 IGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAH 561
Query: 436 ----RLAKEG---DPKMKLQGDLSFRCEDVAALD--------PVTFESPEAFVALPRWSA 480
R KEG D + +G L + + A++ +T+++P+ L R S
Sbjct: 562 GGSCRPRKEGYDCDCPLGFEG-LHCQKAIIEAIEIPQFIGRSYLTYDNPD---ILKRVSG 617
Query: 481 KRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGS 540
R+ ++ + F+TT +GLLL+ G +D+ ++ L DG L ++GS
Sbjct: 618 SRS-NVFMRFKTTAKDGLLLW---------RGDSPMRPNSDFISLGLRDGALVFSYNLGS 667
Query: 541 GGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNS-RSTPFLATGDSEILDLESELYLGG 599
G + + NDG W V RDG+ G I+V+ + + G L++ LY+GG
Sbjct: 668 GVASIMVNG-SFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGG 726
Query: 600 LPE 602
+ E
Sbjct: 727 MKE 729
Score = 94.7 bits (234), Expect = 6e-19
Identities = 99/384 (25%), Positives = 165/384 (42%), Gaps = 37/384 (9%)
Query: 887 SYLALATLQ-AYASMHLFFQFKTTAPDGLLLF---NSGNGNDFIVIELVKGYIHYVFDLG 942
SY+ L+ +Y + + +F+ A DGLLL+ N DF+ + +++ + + F+ G
Sbjct: 161 SYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCG 220
Query: 943 NGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGARN-LDLKGELYI 1001
G +++ S+ + WH V++ RD N + VT S G + + + LY+
Sbjct: 221 TGVAIIV--SETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYL 278
Query: 1002 GGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCD---GPST 1058
GG + L + + GFQGC+ S+ +NGR D+ L G+ G D S
Sbjct: 279 GGAPSAYW--LVRATGTNRGFQGCVQSLAVNGRRIDMRPWPL---GKALSGADVGECSSG 333
Query: 1059 TCTEESCANQGVCLQ-QWDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALITYT---WPP 1114
C E SC + G C + D + C C + + G C D T I +L +Y WP
Sbjct: 334 ICDEASCIHGGTCTAIKADSYICLCPL-GFKGRHCEDAFTLTIPQFRESLRSYAATPWPL 392
Query: 1115 NDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNV--GTDDIT 1172
+ + F VL+ +G D+L +++ G V F+ GT +
Sbjct: 393 EPQHYLSFMEFEITFRPDSGDGVLL-YSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLR 451
Query: 1173 IDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGRQLTIFNSQAAIKIGG--- 1229
++P + G +H +R +R+ N LQVD + E G T I IGG
Sbjct: 452 SEDPLTL---GNWHELRVSRTAKNGILQVDKQKIVEGMAEG-GFTQIKCNTDIFIGGVPN 507
Query: 1230 -----RDQG--RPFQGQVSGLYYN 1246
++ G +PF G + + N
Sbjct: 508 YDDVKKNSGVLKPFSGSIQKIILN 531
Score = 92.8 bits (229), Expect = 2e-18
Identities = 97/365 (26%), Positives = 151/365 (41%), Gaps = 44/365 (12%)
Query: 464 VTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYF 523
VTFE P ++ + I+L+FR +GLLL+ G H R D+
Sbjct: 163 VTFE--------PLKNSYQAFQITLEFRAEAEDGLLLYC-------GENEHG---RGDFM 204
Query: 524 AMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNSRSTPFL-- 581
++ ++ L + G+G + + S K+ G W V RDG G + +N+ TP
Sbjct: 205 SLAIIRRSLQFRFNCGTG-VAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNN-GTPVTGQ 262
Query: 582 ATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRG 641
+ G + + LYLGG P + V G+ GCV+ L ++GR D+R
Sbjct: 263 SQGQYSKITFRTPLYLGGAPSAYWL-------VRATGTNRGFQGCVQSLAVNGRRIDMRP 315
Query: 642 --LAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCRE-GWNRFICDCIGTGFLGRVCERE 698
L +A V CS C A C +GG C + +IC C GF GR CE
Sbjct: 316 WPLGKALSGADVGE-CSSGI---CDEASCIHGGTCTAIKADSYICLC-PLGFKGRHCEDA 370
Query: 699 --ATVLSYDGSMYMKIMLPNAMHTEAE----DVSLRFMSQRAYGLMMATTSRESADTLRL 752
T+ + S+ P + + + + F G+++ + S D L +
Sbjct: 371 FTLTIPQFRESLRSYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSI 430
Query: 753 ELDGGQMKLTVNLGKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVD-NVTVEGQMAGA 811
L GG ++ + G G L + L WH +RV R K+ L VD VEG G
Sbjct: 431 NLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGG 490
Query: 812 HMRLE 816
+++
Sbjct: 491 FTQIK 495
Score = 58.5 bits (140), Expect = 5e-08
Identities = 38/111 (34%), Positives = 59/111 (53%), Gaps = 7/111 (6%)
Query: 901 HLFFQFKTTAPDGLLLFNSGN----GNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPV 956
++F +FKTTA DGLLL+ + +DFI + L G + + ++LG+G + + N
Sbjct: 621 NVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGS--F 678
Query: 957 NDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGA-RNLDLKGELYIGGLSK 1006
ND +WH V RD + D T S G R L++ G LY+GG+ +
Sbjct: 679 NDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKE 729
Score = 46.2 bits (108), Expect = 3e-04
Identities = 49/205 (23%), Positives = 82/205 (40%), Gaps = 20/205 (9%)
Query: 1060 CTEESCANQGVCLQQ--WDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALITYTWPPNDR 1117
C E C+ C+ W G C CT+ G D Y G + +T+ N
Sbjct: 113 CDETLCSADSFCVNDYTWGGSRCQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKN-- 170
Query: 1118 PSTRMDRLAVGFSTHQRSAVLVRV-DSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEP 1176
S + ++ + F +L+ ++ G GD++ L I + ++ FN GT + I
Sbjct: 171 -SYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGT-GVAIIVS 228
Query: 1177 NAIVSDGKYHVVRFTRSGGNATLQVDS-WPVNERYPAGRQLTIFNSQAAIKIGGRDQ--- 1232
+ G +H V R G N LQ+++ PV + + Q + + + +GG
Sbjct: 229 ETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQ--SQGQYSKITFRTPLYLGGAPSAYW 286
Query: 1233 -------GRPFQGQVSGLYYNGLKV 1250
R FQG V L NG ++
Sbjct: 287 LVRATGTNRGFQGCVQSLAVNGRRI 311
>gi|33469929 EGF-like, fibronectin type III and laminin G domains
isoform 1 [Homo sapiens]
Length = 1009
Score = 114 bits (286), Expect = 6e-25
Identities = 141/629 (22%), Positives = 254/629 (40%), Gaps = 118/629 (18%)
Query: 229 CDCSHTGFGGKFCSEE---EHPMEGPAHLTLNSEGKEEFVATFKGNEFFCYDLSHNPIQS 285
C C+ G GG+ CSE+ ++P F G+ + ++ N Q+
Sbjct: 369 CQCT-LGKGGESCSEDIVIQYPQ-------------------FFGHSYVTFEPLKNSYQA 408
Query: 286 STDEITLAFRTLQRNGLMLHTGKS----ADYVNLSLKSGAVWLVINLGSGAFEALVEPVN 341
+ITL FR +GL+L+ G++ D+++L++ ++ N G+G + E
Sbjct: 409 F--QITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSET-- 464
Query: 342 GKFNDNAWHDVRVTRNLRQHAGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYIGGS 401
K WH V + R+ G+ + ++ TG +Q Y+ + Y+GG+
Sbjct: 465 -KIKLGGWHTVMLYRD-----GLNGLL---QLNNGTPVTGQSQGQYSKITFRTPLYLGGA 515
Query: 402 PNTADLPGSPVSNN-FMGCLKDVVYKNNDFKLELSRLAK--------------------- 439
P+ L + +N F GC++ + + L K
Sbjct: 516 PSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCI 575
Query: 440 EGDPKMKLQGD-------LSFR---CEDVAALDPVTF-ESPEAFVALPRWSAKRTGSIS- 487
G ++ D L F+ CED L F ES ++ A P W + +S
Sbjct: 576 HGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATP-WPLEPQHYLSF 634
Query: 488 ----LDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGI 543
+ FR +G+LL+S GS D+ ++ L GH+ D GSG
Sbjct: 635 MEFEITFRPDSGDGVLLYSYD------TGSK------DFLSINLAGGHVEFRFDCGSGTG 682
Query: 544 KLRASSRKVNDGEWCHVDFQRDGRKGSISVNSRS-TPFLATGDSEILDLESELYLGGLPE 602
LR S + G W + R + G + V+ + +A G + +++++GG+P
Sbjct: 683 VLR-SEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPN 741
Query: 603 GGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQ 662
V + + + G ++ + ++ R+ ++ + V V
Sbjct: 742 YDDVKK-------NSGVLKPFSGSIQKIILNDRTIHVKH--DFTSGVNV-----ENAAHP 787
Query: 663 CASAPCRNGGVCREGWNRFICDCIGTGFLGRVCEREAT----VLSYDGSMYMKIMLPNAM 718
C APC +GG CR + CDC GF G C++ + + G Y+ P+ +
Sbjct: 788 CVRAPCAHGGSCRPRKEGYDCDC-PLGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDIL 846
Query: 719 HTEA---EDVSLRFMSQRAYGLMM---ATTSRESADTLRLELDGGQMKLTVNLGKGPETL 772
+ +V +RF + GL++ + R ++D + L L G + + NLG G ++
Sbjct: 847 KRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASI 906
Query: 773 FAGHKLNDNEWHTVRVVRRGKSLQLSVDN 801
ND WH V+ VR G+S +++VD+
Sbjct: 907 MVNGSFNDGRWHRVKAVRDGQSGKITVDD 935
Score = 110 bits (274), Expect = 1e-23
Identities = 108/406 (26%), Positives = 171/406 (42%), Gaps = 57/406 (14%)
Query: 52 ELSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDR 111
E + R ++ +LLY D G DFL + L G + RF + L+ + P+
Sbjct: 636 EFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCG-SGTGVLRSEDPLTLGN 694
Query: 112 WHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVA--SDLFVGGIP--PDVRLSALTLS 167
WH + ++R A+ L VD + + E ++ Q+ +D+F+GG+P DV+ ++ L
Sbjct: 695 WHELRVSRTAKNGILQVD-KQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLK 753
Query: 168 TVKYEPPFRGLLANLKLGERPPALLG--SQGLRGATADPLCAPARNPCANGGLCTVLAPG 225
PF G + + L +R + + G+ A C R PCA+GG C G
Sbjct: 754 ------PFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPC--VRAPCAHGGSCRPRKEG 805
Query: 226 EVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEGKEEFVATFKGNEFFCYDLSHNP--- 282
CDC GF G C + E E + F G + YD NP
Sbjct: 806 -YDCDCP-LGFEGLHCQK------------AIIEAIE--IPQFIGRSYLTYD---NPDIL 846
Query: 283 --IQSSTDEITLAFRTLQRNGLMLHTGKS-----ADYVNLSLKSGAVWLVINLGSGAFEA 335
+ S + + F+T ++GL+L G S +D+++L L+ GA+ NLGSG
Sbjct: 847 KRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASI 906
Query: 336 LVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDF 395
+ VNG FND WH V+ R+ + I+VD TG + L +
Sbjct: 907 M---VNGSFNDGRWHRVKAVRDGQSG--------KITVDDYGARTGKSPGMMRQLNINGA 955
Query: 396 FYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEG 441
Y+GG A +GC+ + D+ + L A +G
Sbjct: 956 LYVGGMKEIALHTNRQYMRGLVGCISHFTL-STDYHISLVEDAVDG 1000
Score = 108 bits (269), Expect = 6e-23
Identities = 153/651 (23%), Positives = 259/651 (39%), Gaps = 84/651 (12%)
Query: 644 EAQGAVGVAPFCSRETLKQCASAPCRNGGVCREG--WNRFICDC-IGTGFLGRVCEREAT 700
+ +G GVA SR C C C W C C +G G G C +
Sbjct: 329 QRKGKNGVA-IMSRLFDMPCDETLCSADSFCVNDYTWGGSRCQCTLGKG--GESCSEDIV 385
Query: 701 VL--SYDGSMYMKIMLPNAMHTEAEDVSLRFMSQRAYGLMMATTSRESA--DTLRLELDG 756
+ + G Y+ P +A ++L F ++ GL++ E D + L +
Sbjct: 386 IQYPQFFGHSYVTFE-PLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIR 444
Query: 757 GQMKLTVNLGKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDNVT-VEGQMAGAHMRL 815
++ N G G + + K+ WHTV + R G + L ++N T V GQ G + ++
Sbjct: 445 RSLQFRFNCGTGVAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKI 504
Query: 816 EFHN--IETGIMTERRFISVVPSN--FIGHLSGLVFNGQ-------PYMDQCKDGDITYC 864
F G + + +N F G + L NG+ P D+ C
Sbjct: 505 TFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGEC 564
Query: 865 ------ELNARFG--LRAIVAD------PVTFKSRSSYLALA--------TLQAYAS--- 899
E + G AI AD P+ FK R A +L++YA+
Sbjct: 565 SSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPW 624
Query: 900 ----------MHLFFQFKTTAPDGLLLFNSGNGN-DFIVIELVKGYIHYVFDLGNGPSLM 948
M F+ + DG+LL++ G+ DF+ I L G++ + FD G+G ++
Sbjct: 625 PLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVL 684
Query: 949 KGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQH--SNGARNLDLKGELYIGGLSK 1006
+ S+ P+ WH + VSR N L++D + + + G + +++IGG+
Sbjct: 685 R--SEDPLTLGNWHELRVSRTAKN-GILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPN 741
Query: 1007 NMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPSTTCTEESCA 1066
+ ++ K F G + + LN R + D + + + C CA
Sbjct: 742 --YDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVN-----VENAAHPCVRAPCA 794
Query: 1067 NQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYIFGK---GGALITYTWPP-NDRPSTRM 1122
+ G C + +G+ CDC + + G C I G + +TY P R S
Sbjct: 795 HGGSCRPRKEGYDCDCPL-GFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSR 853
Query: 1123 DRLAVGFSTHQRSAVLV-RVDS-ASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEPNAIV 1180
+ + F T + +L+ R DS D++ L + G + +N+G+ +I N
Sbjct: 854 SNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASI-MVNGSF 912
Query: 1181 SDGKYHVVRFTRSGGNATLQVDSWPVNERYPAG--RQLTIFNSQAAIKIGG 1229
+DG++H V+ R G + + VD + G RQL N A+ +GG
Sbjct: 913 NDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQL---NINGALYVGG 960
Score = 102 bits (255), Expect = 2e-21
Identities = 143/603 (23%), Positives = 249/603 (41%), Gaps = 101/603 (16%)
Query: 52 ELSFSLRTNATRALLLYLDDG--GDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVAD 109
+++ R A LLLY + G DF+ L ++ L+ RF A + +T +
Sbjct: 410 QITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGV-AIIVSETKIKL 468
Query: 110 DRWHMVLLTRDARRTALAVD-GEARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLST 168
WH V+L RD L ++ G + + + ++ + L++GG P L T +
Sbjct: 469 GGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTN 528
Query: 169 VKYEPPFRGLLANLKLGERPPALLGSQGLRGAT----ADPLCAPARNPCANGGLCTVLAP 224
++ + L N + + P LG + L GA + +C A C +GG CT +
Sbjct: 529 RGFQGCVQSLAVNGRRIDMRPWPLG-KALSGADVGECSSGICDEAS--CIHGGTCTAIKA 585
Query: 225 GEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEGKEEFVATFKGNEFFCYDLSHNPIQ 284
C C GF G+ C + TL E + ++ + P++
Sbjct: 586 DSYICLCP-LGFKGRHCEDA---------FTLTIPQFRESLRSYAATPW--------PLE 627
Query: 285 S----STDEITLAFRTLQRNGLMLH---TGKSADYVNLSLKSGAVWLVINLGSGAFEALV 337
S E + FR +G++L+ TG S D+++++L G V + GSG
Sbjct: 628 PQHYLSFMEFEITFRPDSGDGVLLYSYDTG-SKDFLSINLAGGHVEFRFDCGSGTGVLRS 686
Query: 338 EPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFY 397
E N WH++RV+R + GI + VD G + +T + + +
Sbjct: 687 EDPLTLGN---WHELRVSRTAKN--GI------LQVDKQKIVEGMAEGGFTQIKCNTDIF 735
Query: 398 IGGSPNTADL-PGSPVSNNFMGCLKDV------VYKNNDFKLELS--------------- 435
IGG PN D+ S V F G ++ + ++ +DF ++
Sbjct: 736 IGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAH 795
Query: 436 ----RLAKEG---DPKMKLQGDLSFRCEDVAALD--------PVTFESPEAFVALPRWSA 480
R KEG D + +G L + + A++ +T+++P+ L R S
Sbjct: 796 GGSCRPRKEGYDCDCPLGFEG-LHCQKAIIEAIEIPQFIGRSYLTYDNPD---ILKRVSG 851
Query: 481 KRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGS 540
R+ ++ + F+TT +GLLL+ G +D+ ++ L DG L ++GS
Sbjct: 852 SRS-NVFMRFKTTAKDGLLLW---------RGDSPMRPNSDFISLGLRDGALVFSYNLGS 901
Query: 541 GGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNS-RSTPFLATGDSEILDLESELYLGG 599
G + + NDG W V RDG+ G I+V+ + + G L++ LY+GG
Sbjct: 902 GVASIMVNG-SFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGG 960
Query: 600 LPE 602
+ E
Sbjct: 961 MKE 963
Score = 94.7 bits (234), Expect = 6e-19
Identities = 99/384 (25%), Positives = 165/384 (42%), Gaps = 37/384 (9%)
Query: 887 SYLALATLQ-AYASMHLFFQFKTTAPDGLLLF---NSGNGNDFIVIELVKGYIHYVFDLG 942
SY+ L+ +Y + + +F+ A DGLLL+ N DF+ + +++ + + F+ G
Sbjct: 395 SYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCG 454
Query: 943 NGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGARN-LDLKGELYI 1001
G +++ S+ + WH V++ RD N + VT S G + + + LY+
Sbjct: 455 TGVAIIV--SETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYL 512
Query: 1002 GGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCD---GPST 1058
GG + L + + GFQGC+ S+ +NGR D+ L G+ G D S
Sbjct: 513 GGAPSAYW--LVRATGTNRGFQGCVQSLAVNGRRIDMRPWPL---GKALSGADVGECSSG 567
Query: 1059 TCTEESCANQGVCLQ-QWDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALITYT---WPP 1114
C E SC + G C + D + C C + + G C D T I +L +Y WP
Sbjct: 568 ICDEASCIHGGTCTAIKADSYICLCPL-GFKGRHCEDAFTLTIPQFRESLRSYAATPWPL 626
Query: 1115 NDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNV--GTDDIT 1172
+ + F VL+ +G D+L +++ G V F+ GT +
Sbjct: 627 EPQHYLSFMEFEITFRPDSGDGVLL-YSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLR 685
Query: 1173 IDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGRQLTIFNSQAAIKIGG--- 1229
++P + G +H +R +R+ N LQVD + E G T I IGG
Sbjct: 686 SEDPLTL---GNWHELRVSRTAKNGILQVDKQKIVEGMAEG-GFTQIKCNTDIFIGGVPN 741
Query: 1230 -----RDQG--RPFQGQVSGLYYN 1246
++ G +PF G + + N
Sbjct: 742 YDDVKKNSGVLKPFSGSIQKIILN 765
Score = 92.8 bits (229), Expect = 2e-18
Identities = 97/365 (26%), Positives = 151/365 (41%), Gaps = 44/365 (12%)
Query: 464 VTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYF 523
VTFE P ++ + I+L+FR +GLLL+ G H R D+
Sbjct: 397 VTFE--------PLKNSYQAFQITLEFRAEAEDGLLLYC-------GENEHG---RGDFM 438
Query: 524 AMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNSRSTPFL-- 581
++ ++ L + G+G + + S K+ G W V RDG G + +N+ TP
Sbjct: 439 SLAIIRRSLQFRFNCGTG-VAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNN-GTPVTGQ 496
Query: 582 ATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRG 641
+ G + + LYLGG P + V G+ GCV+ L ++GR D+R
Sbjct: 497 SQGQYSKITFRTPLYLGGAPSAYWL-------VRATGTNRGFQGCVQSLAVNGRRIDMRP 549
Query: 642 --LAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCRE-GWNRFICDCIGTGFLGRVCERE 698
L +A V CS C A C +GG C + +IC C GF GR CE
Sbjct: 550 WPLGKALSGADVGE-CSSGI---CDEASCIHGGTCTAIKADSYICLC-PLGFKGRHCEDA 604
Query: 699 --ATVLSYDGSMYMKIMLPNAMHTEAE----DVSLRFMSQRAYGLMMATTSRESADTLRL 752
T+ + S+ P + + + + F G+++ + S D L +
Sbjct: 605 FTLTIPQFRESLRSYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSI 664
Query: 753 ELDGGQMKLTVNLGKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVD-NVTVEGQMAGA 811
L GG ++ + G G L + L WH +RV R K+ L VD VEG G
Sbjct: 665 NLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGG 724
Query: 812 HMRLE 816
+++
Sbjct: 725 FTQIK 729
Score = 58.5 bits (140), Expect = 5e-08
Identities = 38/111 (34%), Positives = 59/111 (53%), Gaps = 7/111 (6%)
Query: 901 HLFFQFKTTAPDGLLLFNSGN----GNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPV 956
++F +FKTTA DGLLL+ + +DFI + L G + + ++LG+G + + N
Sbjct: 855 NVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGS--F 912
Query: 957 NDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGA-RNLDLKGELYIGGLSK 1006
ND +WH V RD + D T S G R L++ G LY+GG+ +
Sbjct: 913 NDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKE 963
Score = 46.2 bits (108), Expect = 3e-04
Identities = 49/205 (23%), Positives = 82/205 (40%), Gaps = 20/205 (9%)
Query: 1060 CTEESCANQGVCLQQ--WDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALITYTWPPNDR 1117
C E C+ C+ W G C CT+ G D Y G + +T+ N
Sbjct: 347 CDETLCSADSFCVNDYTWGGSRCQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKN-- 404
Query: 1118 PSTRMDRLAVGFSTHQRSAVLVRV-DSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEP 1176
S + ++ + F +L+ ++ G GD++ L I + ++ FN GT + I
Sbjct: 405 -SYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGT-GVAIIVS 462
Query: 1177 NAIVSDGKYHVVRFTRSGGNATLQVDS-WPVNERYPAGRQLTIFNSQAAIKIGGRDQ--- 1232
+ G +H V R G N LQ+++ PV + + Q + + + +GG
Sbjct: 463 ETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQ--SQGQYSKITFRTPLYLGGAPSAYW 520
Query: 1233 -------GRPFQGQVSGLYYNGLKV 1250
R FQG V L NG ++
Sbjct: 521 LVRATGTNRGFQGCVQSLAVNGRRI 545
>gi|239743797 PREDICTED: similar to cell recognition molecule CASPR3
[Homo sapiens]
Length = 944
Score = 112 bits (280), Expect = 3e-24
Identities = 108/383 (28%), Positives = 172/383 (44%), Gaps = 48/383 (12%)
Query: 881 TFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSGNGNDFIVIEL-VKGYIHYVF 939
+F + +SYL + + F FKTT G+ + N G DFI IEL + + F
Sbjct: 529 SFNTETSYLHFPAFHGELTADVCFFFKTTVSSGVFMENLGI-TDFIRIELRAPTEVTFSF 587
Query: 940 DLGNGPSLMKGNSDKPVNDNQWHNVVVSRD--PGNVHTLKIDSRTVTQHSNGARNLDLKG 997
D+GNGP + S P NDNQWH+V R+ ++ ++ + ++G L L
Sbjct: 588 DVGNGPCEVTVQSPTPFNDNQWHHVRAERNVKGASLQVDQLPQKMQPAPADGHVRLQLNS 647
Query: 998 ELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPS 1057
+L+IGG + + GF GC+ S+ LNG DL A G VE GC G
Sbjct: 648 QLFIGGTA-----------TRQRGFLGCIRSLQLNGVALDLEERATVMPG-VEPGCAGHC 695
Query: 1058 TTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALI-----TYTW 1112
+T C N G C ++ G TCDC ++Y GP C++ + Y F G ++ YT
Sbjct: 696 ST-YGHLCRNGGRCREKRRGVTCDCAFSAYDGPFCSNEISAY-FATGSSMTYHFQEHYTL 753
Query: 1113 PPN----------DRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHI-DQGTVG 1161
N D TR + + + F T + ++L+ V +S +YL + + + G++
Sbjct: 754 SENSSSLVSSLHRDVTLTR-EMITLSFRTTRTPSLLLYV--SSFYEEYLSVILANNGSLQ 810
Query: 1162 VIFNV----GTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVD-SWPVNERYPAGRQL 1216
+ + + D T D N ++DG+ H V+ R ++V+ S +G +
Sbjct: 811 IRYKLDRHQNPDAFTFDFKN--MADGQLHQVKINREEAVVMVEVNQSAKKQVILSSGTEF 868
Query: 1217 TIFNSQAAIKIGGR----DQGRP 1235
S K+ GR D+G P
Sbjct: 869 NAVKSLILGKVLGRSGPVDEGEP 891
Score = 76.3 bits (186), Expect = 2e-13
Identities = 82/370 (22%), Positives = 151/370 (40%), Gaps = 63/370 (17%)
Query: 457 DVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSS 516
D + + +F + +++ P + + T + F+TT +G+ + + G
Sbjct: 521 DKSFWNSASFNTETSYLHFPAFHGELTADVCFFFKTTVSSGVFMENLGI----------- 569
Query: 517 AQRADYFAMEL-LDGHLYLLLDMGSGGIKLRASS-RKVNDGEWCHVDFQRDGRKGSISVN 574
D+ +EL + D+G+G ++ S ND +W HV +R+ + S+ V+
Sbjct: 570 ---TDFIRIELRAPTEVTFSFDVGNGPCEVTVQSPTPFNDNQWHHVRAERNVKGASLQVD 626
Query: 575 S---RSTPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLF 631
+ P A G L L S+L++GG TA + G++GC+R L
Sbjct: 627 QLPQKMQPAPADGHVR-LQLNSQLFIGG----------------TATRQRGFLGCIRSLQ 669
Query: 632 IDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAP--CRNGGVCREGWNRFICDCIGTG 689
++G + DL A GV P C+ C++ CRNGG CRE CDC +
Sbjct: 670 LNGVALDLEERATVMP--GVEPGCAGH----CSTYGHLCRNGGRCREKRRGVTCDCAFSA 723
Query: 690 FLGRVCEREATVLSYDGSMYM------------KIMLPNAMHTEA----EDVSLRFMSQR 733
+ G C E + GS L +++H + E ++L F + R
Sbjct: 724 YDGPFCSNEISAYFATGSSMTYHFQEHYTLSENSSSLVSSLHRDVTLTREMITLSFRTTR 783
Query: 734 AYGLMMATTS--RESADTLRLELDGGQMKLTVNLGKGPETL-FAGHKLNDNEWHTVRVVR 790
L++ +S E + Q++ ++ + P+ F + D + H V++ R
Sbjct: 784 TPSLLLYVSSFYEEYLSVILANNGSLQIRYKLDRHQNPDAFTFDFKNMADGQLHQVKINR 843
Query: 791 RGKSLQLSVD 800
+ + V+
Sbjct: 844 EEAVVMVEVN 853
Score = 58.5 bits (140), Expect = 5e-08
Identities = 58/218 (26%), Positives = 87/218 (39%), Gaps = 36/218 (16%)
Query: 100 TLQLDTPVADDRWHMVLLTRDARRTALAVD--GEARAAEVRSKRREMQVASDLFVGGIPP 157
T+Q TP D++WH V R+ + +L VD + +Q+ S LF+GG
Sbjct: 597 TVQSPTPFNDNQWHHVRAERNVKGASLQVDQLPQKMQPAPADGHVRLQLNSQLFIGG--- 653
Query: 158 DVRLSALTLSTVKYEPPFRGLLANLKLG-------ERPPALLGSQ-GLRGATADPLCAPA 209
T + F G + +L+L ER + G + G G C+
Sbjct: 654 ----------TATRQRGFLGCIRSLQLNGVALDLEERATVMPGVEPGCAGH-----CSTY 698
Query: 210 RNPCANGGLCTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEGKEEFVA--T 267
+ C NGG C G V CDC+ + + G FCS E A+ S F T
Sbjct: 699 GHLCRNGGRCREKRRG-VTCDCAFSAYDGPFCSNEI-----SAYFATGSSMTYHFQEHYT 752
Query: 268 FKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLH 305
N H + + + ITL+FRT + L+L+
Sbjct: 753 LSENSSSLVSSLHRDVTLTREMITLSFRTTRTPSLLLY 790
Score = 52.0 bits (123), Expect = 5e-06
Identities = 26/77 (33%), Positives = 40/77 (51%), Gaps = 5/77 (6%)
Query: 622 GYVGCVRDLFIDGRSRDLRGLAEAQGAVGV---APFCSRETLKQCASAPCRNGGVCREGW 678
G+ GC+R + I ++ D + QGA+G S +C + C +GG C + W
Sbjct: 202 GFQGCLRLITIGDKAVD--PILVQQGALGSFRDLQIDSCGITDRCLPSYCEHGGECSQSW 259
Query: 679 NRFICDCIGTGFLGRVC 695
+ F CDC+GTG+ G C
Sbjct: 260 DTFSCDCLGTGYTGETC 276
Score = 51.2 bits (121), Expect = 8e-06
Identities = 26/76 (34%), Positives = 35/76 (46%), Gaps = 3/76 (3%)
Query: 1021 GFQGCLASVDLNGRLPDLIA---DALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDG 1077
GFQGCL + + + D I AL ++ G + C C + G C Q WD
Sbjct: 202 GFQGCLRLITIGDKAVDPILVQQGALGSFRDLQIDSCGITDRCLPSYCEHGGECSQSWDT 261
Query: 1078 FTCDCTMTSYGGPVCN 1093
F+CDC T Y G C+
Sbjct: 262 FSCDCLGTGYTGETCH 277
Score = 43.9 bits (102), Expect = 0.001
Identities = 73/314 (23%), Positives = 114/314 (36%), Gaps = 71/314 (22%)
Query: 717 AMHTE-AEDVSLRFMSQRAYGLMMATTSRESADTLRLELDGG-QMKLTVNLGKGP--ETL 772
A H E DV F + + G+ M D +R+EL ++ + ++G GP T+
Sbjct: 541 AFHGELTADVCFFFKTTVSSGVFMENLG--ITDFIRIELRAPTEVTFSFDVGNGPCEVTV 598
Query: 773 FAGHKLNDNEWHTVRVVRRGKSLQLSVDNVTVEGQMAGA--HMRLEFHN--IETGIMTER 828
+ NDN+WH VR R K L VD + + Q A A H+RL+ ++ G T +
Sbjct: 599 QSPTPFNDNQWHHVRAERNVKGASLQVDQLPQKMQPAPADGHVRLQLNSQLFIGGTATRQ 658
Query: 829 RFISVVPSNFIGHLSGLVFNG--------QPYMDQCKDGDITYCEL---------NARFG 871
R F+G + L NG M + G +C R
Sbjct: 659 R-------GFLGCIRSLQLNGVALDLEERATVMPGVEPGCAGHCSTYGHLCRNGGRCREK 711
Query: 872 LRAIVAD--------PVTFKSRSSYLALATLQAY----------------ASMH------ 901
R + D P S+Y A + Y +S+H
Sbjct: 712 RRGVTCDCAFSAYDGPFCSNEISAYFATGSSMTYHFQEHYTLSENSSSLVSSLHRDVTLT 771
Query: 902 ---LFFQFKTTAPDGLLLFNSGNGNDFIVIELVKG---YIHYVFDLGNGPSLMKGNSDKP 955
+ F+TT LLL+ S +++ + L I Y D P + K
Sbjct: 772 REMITLSFRTTRTPSLLLYVSSFYEEYLSVILANNGSLQIRYKLDRHQNPDAFTFDF-KN 830
Query: 956 VNDNQWHNVVVSRD 969
+ D Q H V ++R+
Sbjct: 831 MADGQLHQVKINRE 844
Score = 40.0 bits (92), Expect = 0.019
Identities = 21/74 (28%), Positives = 38/74 (51%), Gaps = 2/74 (2%)
Query: 287 TDEITLAFRTLQRNGLMLHTGKSADYVNLSLKSGA-VWLVINLGSGAFEALVEPVNGKFN 345
T ++ F+T +G+ + D++ + L++ V ++G+G E V+ FN
Sbjct: 547 TADVCFFFKTTVSSGVFMENLGITDFIRIELRAPTEVTFSFDVGNGPCEVTVQSPT-PFN 605
Query: 346 DNAWHDVRVTRNLR 359
DN WH VR RN++
Sbjct: 606 DNQWHHVRAERNVK 619
Score = 34.7 bits (78), Expect = 0.78
Identities = 27/106 (25%), Positives = 51/106 (48%), Gaps = 4/106 (3%)
Query: 53 LSFSLRTNATRALLLYLDDGGDCDFLELLLVD-GRLRLRFTLSCAE-PATLQLDTP-VAD 109
++ S RT T +LLLY+ + ++L ++L + G L++R+ L + P D +AD
Sbjct: 775 ITLSFRTTRTPSLLLYVSSFYE-EYLSVILANNGSLQIRYKLDRHQNPDAFTFDFKNMAD 833
Query: 110 DRWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVGGI 155
+ H V + R+ + V+ A+ + S E L +G +
Sbjct: 834 GQLHQVKINREEAVVMVEVNQSAKKQVILSSGTEFNAVKSLILGKV 879
>gi|33469935 EGF-like, fibronectin type III and laminin G domains
isoform 3 [Homo sapiens]
Length = 375
Score = 110 bits (274), Expect = 1e-23
Identities = 108/406 (26%), Positives = 171/406 (42%), Gaps = 57/406 (14%)
Query: 52 ELSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDR 111
E + R ++ +LLY D G DFL + L G + RF + L+ + P+
Sbjct: 2 EFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCG-SGTGVLRSEDPLTLGN 60
Query: 112 WHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVA--SDLFVGGIP--PDVRLSALTLS 167
WH + ++R A+ L VD + + E ++ Q+ +D+F+GG+P DV+ ++ L
Sbjct: 61 WHELRVSRTAKNGILQVD-KQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLK 119
Query: 168 TVKYEPPFRGLLANLKLGERPPALLG--SQGLRGATADPLCAPARNPCANGGLCTVLAPG 225
PF G + + L +R + + G+ A C R PCA+GG C G
Sbjct: 120 ------PFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPC--VRAPCAHGGSCRPRKEG 171
Query: 226 EVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEGKEEFVATFKGNEFFCYDLSHNP--- 282
CDC GF G C + E E + F G + YD NP
Sbjct: 172 -YDCDCP-LGFEGLHCQK------------AIIEAIE--IPQFIGRSYLTYD---NPDIL 212
Query: 283 --IQSSTDEITLAFRTLQRNGLMLHTGKS-----ADYVNLSLKSGAVWLVINLGSGAFEA 335
+ S + + F+T ++GL+L G S +D+++L L+ GA+ NLGSG
Sbjct: 213 KRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASI 272
Query: 336 LVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDF 395
+ VNG FND WH V+ R+ + I+VD TG + L +
Sbjct: 273 M---VNGSFNDGRWHRVKAVRDGQSG--------KITVDDYGARTGKSPGMMRQLNINGA 321
Query: 396 FYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEG 441
Y+GG A +GC+ + D+ + L A +G
Sbjct: 322 LYVGGMKEIALHTNRQYMRGLVGCISHFTL-STDYHISLVEDAVDG 366
Score = 87.4 bits (215), Expect = 1e-16
Identities = 77/325 (23%), Positives = 140/325 (43%), Gaps = 39/325 (12%)
Query: 488 LDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRA 547
+ FR +G+LL+S GS D+ ++ L GH+ D GSG LR
Sbjct: 5 ITFRPDSGDGVLLYSYD------TGSK------DFLSINLAGGHVEFRFDCGSGTGVLR- 51
Query: 548 SSRKVNDGEWCHVDFQRDGRKGSISVNSRS-TPFLATGDSEILDLESELYLGGLPEGGRV 606
S + G W + R + G + V+ + +A G + +++++GG+P V
Sbjct: 52 SEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDV 111
Query: 607 DLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASA 666
+ + + G ++ + ++ R+ ++ + V V C A
Sbjct: 112 KK-------NSGVLKPFSGSIQKIILNDRTIHVKH--DFTSGVNV-----ENAAHPCVRA 157
Query: 667 PCRNGGVCREGWNRFICDCIGTGFLGRVCEREAT----VLSYDGSMYMKIMLPNAMHTEA 722
PC +GG CR + CDC GF G C++ + + G Y+ P+ + +
Sbjct: 158 PCAHGGSCRPRKEGYDCDC-PLGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVS 216
Query: 723 ---EDVSLRFMSQRAYGLMM---ATTSRESADTLRLELDGGQMKLTVNLGKGPETLFAGH 776
+V +RF + GL++ + R ++D + L L G + + NLG G ++
Sbjct: 217 GSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNG 276
Query: 777 KLNDNEWHTVRVVRRGKSLQLSVDN 801
ND WH V+ VR G+S +++VD+
Sbjct: 277 SFNDGRWHRVKAVRDGQSGKITVDD 301
Score = 86.7 bits (213), Expect = 2e-16
Identities = 84/341 (24%), Positives = 150/341 (43%), Gaps = 26/341 (7%)
Query: 900 MHLFFQFKTTAPDGLLLFNSGNGN-DFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVND 958
M F+ + DG+LL++ G+ DF+ I L G++ + FD G+G +++ S+ P+
Sbjct: 1 MEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLR--SEDPLTL 58
Query: 959 NQWHNVVVSRDPGNVHTLKIDSRTVTQH--SNGARNLDLKGELYIGGLSKNMFSNLPKLV 1016
WH + VSR N L++D + + + G + +++IGG+ + ++ K
Sbjct: 59 GNWHELRVSRTAKN-GILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPN--YDDVKKNS 115
Query: 1017 ASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWD 1076
F G + + LN R + D + + + C CA+ G C + +
Sbjct: 116 GVLKPFSGSIQKIILNDRTIHVKHDFTSGVN-----VENAAHPCVRAPCAHGGSCRPRKE 170
Query: 1077 GFTCDCTMTSYGGPVCNDPGTTYIFGK---GGALITYTWPP-NDRPSTRMDRLAVGFSTH 1132
G+ CDC + + G C I G + +TY P R S + + F T
Sbjct: 171 GYDCDCPL-GFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTT 229
Query: 1133 QRSAVLV-RVDS-ASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRF 1190
+ +L+ R DS D++ L + G + +N+G+ +I N +DG++H V+
Sbjct: 230 AKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASI-MVNGSFNDGRWHRVKA 288
Query: 1191 TRSGGNATLQVDSWPVNERYPAG--RQLTIFNSQAAIKIGG 1229
R G + + VD + G RQL N A+ +GG
Sbjct: 289 VRDGQSGKITVDDYGARTGKSPGMMRQL---NINGALYVGG 326
Score = 58.5 bits (140), Expect = 5e-08
Identities = 38/111 (34%), Positives = 59/111 (53%), Gaps = 7/111 (6%)
Query: 901 HLFFQFKTTAPDGLLLFNSGN----GNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPV 956
++F +FKTTA DGLLL+ + +DFI + L G + + ++LG+G + + N
Sbjct: 221 NVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGS--F 278
Query: 957 NDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGA-RNLDLKGELYIGGLSK 1006
ND +WH V RD + D T S G R L++ G LY+GG+ +
Sbjct: 279 NDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKE 329
Score = 38.9 bits (89), Expect = 0.041
Identities = 25/94 (26%), Positives = 41/94 (43%), Gaps = 1/94 (1%)
Query: 724 DVSLRFMSQRAYGLMMATTSRESADTLRLELDGGQMKLTVNLGKGPETLFAGHKLNDNEW 783
+ + F G+++ + S D L + L GG ++ + G G L + L W
Sbjct: 2 EFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNW 61
Query: 784 HTVRVVRRGKSLQLSVD-NVTVEGQMAGAHMRLE 816
H +RV R K+ L VD VEG G +++
Sbjct: 62 HELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIK 95
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 100 bits (249), Expect = 1e-20
Identities = 101/398 (25%), Positives = 153/398 (38%), Gaps = 64/398 (16%)
Query: 76 DFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDRWHMVLLTRDARRTALAVDGEARAA 135
DF+ L +V G L R+ L A L+ P+A RWH V R + +L V+G
Sbjct: 3978 DFVSLAMVGGHLEFRYELGSGL-AVLRSAEPLALGRWHRVSAERLNKDGSLRVNGGRPVL 4036
Query: 136 EVR-SKRREMQVASDLFVGGIPPDVRLSALTLSTVKYEPPFRGLLANLKLGERPPALLGS 194
K + + + + L++GG+ P V LS T + + + N K + + LGS
Sbjct: 4037 RSSPGKSQGLNLHTLLYLGGVEPSVPLSPATNMSAHFRGCVGEVSVNGKRLDLTYSFLGS 4096
Query: 195 QGLRGATADPLCAPARNPCANGGLCTVLAPGEVGCDCSHTGFGGKFCSEEEHP------- 247
QG+ C R PC +G C E C C GF G C EE+P
Sbjct: 4097 QGIGQCYDSSPCE--RQPCQHGATCMPAGEYEFQCLC-RDGFKGDLCEHEENPCQLREPC 4153
Query: 248 ----------------------MEGPAHLTLNSEGKEE----------FVATFKGNEFFC 275
+G H S+ E + A F + F
Sbjct: 4154 LHGGTCQGTRCLCLPGFSGPRCQQGSGHGIAESDWHLEGSGGNDAPGQYGAYFHDDGFLA 4213
Query: 276 YD--LSHNPIQSSTDEITLAFRTLQRNGLML-------HTGKSADYVNLSLKSGAVWLVI 326
+ + + + I L RT +GL+L G+ D+++L L+ G +
Sbjct: 4214 FPGHVFSRSLPEVPETIELEVRTSTASGLLLWQGVEVGEAGQGKDFISLGLQDGHLVFRY 4273
Query: 327 NLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVTISVDGILTTTGYTQED 386
LGSG + E ND WH V R R+ + I VDG +G +
Sbjct: 4274 QLGSGEARLVSED---PINDGEWHRVTALREGRRGS--------IQVDGEELVSGRSPGP 4322
Query: 387 YTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVV 424
+ + YIGG+P+ A L G S+ GC+K++V
Sbjct: 4323 NVAVNAKGSVYIGGAPDVATLTGGRFSSGITGCVKNLV 4360
Score = 92.0 bits (227), Expect = 4e-18
Identities = 103/442 (23%), Positives = 174/442 (39%), Gaps = 109/442 (24%)
Query: 449 GDLSFRCEDVAALDPVTFESPEAFVALPRWS-AKRTGSISLDFRTTEPNGLLLFSQGRRA 507
G RCE+ + + +++ALP + + ++F+ P+G+LLFS G+
Sbjct: 3915 GRSGLRCEEGVTVTTPSLSGAGSYLALPALTNTHHELRLDVEFKPLAPDGVLLFSGGK-- 3972
Query: 508 GGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGR 567
S D+ ++ ++ GHL ++GSG LR S+ + G W V +R +
Sbjct: 3973 --------SGPVEDFVSLAMVGGHLEFRYELGSGLAVLR-SAEPLALGRWHRVSAERLNK 4023
Query: 568 KGSISVNS-----RSTPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAG 622
GS+ VN RS+P G S+ L+L + LYLGG+ +PL P + A
Sbjct: 4024 DGSLRVNGGRPVLRSSP----GKSQGLNLHTLLYLGGVEPS----VPLSP---ATNMSAH 4072
Query: 623 YVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGG---------- 672
+ GCV ++ ++G+ DL +G S C PC++G
Sbjct: 4073 FRGCVGEVSVNGKRLDLTYSFLGSQGIGQCYDSS-----PCERQPCQHGATCMPAGEYEF 4127
Query: 673 --VCREGWNRFICD-----------------CIGT------GFLGRVCER---------- 697
+CR+G+ +C+ C GT GF G C++
Sbjct: 4128 QCLCRDGFKGDLCEHEENPCQLREPCLHGGTCQGTRCLCLPGFSGPRCQQGSGHGIAESD 4187
Query: 698 --------------------EATVLSYDGSMYMKIMLPNAMHTEAEDVSLRFMSQRAYGL 737
+ L++ G ++ + LP T + L + A GL
Sbjct: 4188 WHLEGSGGNDAPGQYGAYFHDDGFLAFPGHVFSR-SLPEVPET----IELEVRTSTASGL 4242
Query: 738 MM-----ATTSRESADTLRLELDGGQMKLTVNLGKGPETLFAGHKLNDNEWHTVRVVRRG 792
++ + + D + L L G + LG G L + +ND EWH V +R G
Sbjct: 4243 LLWQGVEVGEAGQGKDFISLGLQDGHLVFRYQLGSGEARLVSEDPINDGEWHRVTALREG 4302
Query: 793 KSLQLSVD-NVTVEGQMAGAHM 813
+ + VD V G+ G ++
Sbjct: 4303 RRGSIQVDGEELVSGRSPGPNV 4324
Score = 88.6 bits (218), Expect = 5e-17
Identities = 95/387 (24%), Positives = 145/387 (37%), Gaps = 69/387 (17%)
Query: 463 PVTFESPEAFVALPRWS-AKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRAD 521
P ++P +F+ LP A R I + FR +G+LL++ G++ G+ ++ + ++ D
Sbjct: 3664 PYFTQTPYSFLPLPTIKDAYRKFEIKITFRPDSADGMLLYN-GQKRVPGSPTNLANRQPD 3722
Query: 522 YFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNSRSTPFL 581
+ + L+ G D GSG +R + + G + V R +GS+ V + P
Sbjct: 3723 FISFGLVGGRPEFRFDAGSGMATIRHPT-PLALGHFHTVTLLRSLTQGSLIVGDLA-PVN 3780
Query: 582 ATGDSEI--LDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDL 639
T + LDL ELYLGG P+ G + A L +G++GCVR+L I G
Sbjct: 3781 GTSQGKFQGLDLNEELYLGGYPDYGAIP--------KAGLSSGFIGCVRELRIQGEEIVF 3832
Query: 640 RGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCREG-WNRFICDCIGTGFLGRVCERE 698
L + P C PC+NGG C + + ++C C GF G CE
Sbjct: 3833 HDLNLTAHGISHCP--------TCRDRPCQNGGQCHDSESSSYVCVC-PAGFTGSRCEHS 3883
Query: 699 ATV---------------------------------------------LSYDGSMYMKIM 713
+ LS GS
Sbjct: 3884 QALHCHPEACGPDATCVNRPDGRGYTCRCHLGRSGLRCEEGVTVTTPSLSGAGSYLALPA 3943
Query: 714 LPNAMHTEAEDVSLRFMSQRAYGLMMATTSRESADTLRLELDGGQMKLTVNLGKGPETLF 773
L N H DV + ++ L S D + L + GG ++ LG G L
Sbjct: 3944 LTNTHHELRLDVEFKPLAPDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLR 4003
Query: 774 AGHKLNDNEWHTVRVVRRGKSLQLSVD 800
+ L WH V R K L V+
Sbjct: 4004 SAEPLALGRWHRVSAERLNKDGSLRVN 4030
Score = 86.7 bits (213), Expect = 2e-16
Identities = 111/442 (25%), Positives = 176/442 (39%), Gaps = 93/442 (21%)
Query: 864 CELNARFGLRAIVADPVTFKSRS---SYLALATL-QAYASMHLFFQFKTTAPDGLLLFNS 919
C L R GLR VT S S SYLAL L + + L +FK APDG+LLF+
Sbjct: 3912 CHLG-RSGLRCEEGVTVTTPSLSGAGSYLALPALTNTHHELRLDVEFKPLAPDGVLLFSG 3970
Query: 920 GNG---NDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTL 976
G DF+ + +V G++ + ++LG+G ++++ S +P+ +WH V R +
Sbjct: 3971 GKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLR--SAEPLALGRWHRVSAERLNKDGSLR 4028
Query: 977 KIDSRTVTQHSNG-ARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRL 1035
R V + S G ++ L+L LY+GG+ ++ L F+GC+ V +NG+
Sbjct: 4029 VNGGRPVLRSSPGKSQGLNLHTLLYLGGVEPSV--PLSPATNMSAHFRGCVGEVSVNGKR 4086
Query: 1036 PDLIADALHRIGQVERGCDGPSTTCTEESCANQGVCLQQW---------DGF-------- 1078
DL L G G S+ C + C + C+ DGF
Sbjct: 4087 LDLTYSFL---GSQGIGQCYDSSPCERQPCQHGATCMPAGEYEFQCLCRDGFKGDLCEHE 4143
Query: 1079 --------------TCDCT----MTSYGGPVCNDPGTTYIFGKGGALITYTW-----PPN 1115
TC T + + GP C G G + W N
Sbjct: 4144 ENPCQLREPCLHGGTCQGTRCLCLPGFSGPRCQQ-------GSGHGIAESDWHLEGSGGN 4196
Query: 1116 DRPSTR----MDRLAVGFSTHQRSAVL----------VRVDSASGL-------------- 1147
D P D + F H S L VR +ASGL
Sbjct: 4197 DAPGQYGAYFHDDGFLAFPGHVFSRSLPEVPETIELEVRTSTASGLLLWQGVEVGEAGQG 4256
Query: 1148 GDYLQLHIDQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVN 1207
D++ L + G + + +G+ + + + I +DG++H V R G ++QVD +
Sbjct: 4257 KDFISLGLQDGHLVFRYQLGSGEARLVSEDPI-NDGEWHRVTALREGRRGSIQVDGEELV 4315
Query: 1208 ERYPAGRQLTIFNSQAAIKIGG 1229
G + + N++ ++ IGG
Sbjct: 4316 SGRSPGPNVAV-NAKGSVYIGG 4336
Score = 68.9 bits (167), Expect = 4e-11
Identities = 49/154 (31%), Positives = 76/154 (49%), Gaps = 27/154 (17%)
Query: 485 SISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIK 544
+I L+ RT+ +GLLL+ QG G + Q D+ ++ L DGHL +GSG +
Sbjct: 4229 TIELEVRTSTASGLLLW-QGVEVG------EAGQGKDFISLGLQDGHLVFRYQLGSGEAR 4281
Query: 545 LRASSRKVNDGEWCHVDFQRDGRKGSISVNSRS-TPFLATGDSEILDLESELYLGGLPE- 602
L S +NDGEW V R+GR+GSI V+ + G + ++ + +Y+GG P+
Sbjct: 4282 L-VSEDPINDGEWHRVTALREGRRGSIQVDGEELVSGRSPGPNVAVNAKGSVYIGGAPDV 4340
Query: 603 ----GGRVDLPLPPEVWTAALRAGYVGCVRDLFI 632
GGR +G GCV++L +
Sbjct: 4341 ATLTGGR-------------FSSGITGCVKNLVL 4361
Score = 59.3 bits (142), Expect = 3e-08
Identities = 73/283 (25%), Positives = 109/283 (38%), Gaps = 29/283 (10%)
Query: 887 SYLALATLQ-AYASMHLFFQFKTTAPDGLLLFN------------SGNGNDFIVIELVKG 933
S+L L T++ AY + F+ + DG+LL+N + DFI LV G
Sbjct: 3672 SFLPLPTIKDAYRKFEIKITFRPDSADGMLLYNGQKRVPGSPTNLANRQPDFISFGLVGG 3731
Query: 934 YIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGA-RN 992
+ FD G+G + ++ P+ +H V + R + D V S G +
Sbjct: 3732 RPEFRFDAGSGMATIR--HPTPLALGHFHTVTLLRSLTQGSLIVGDLAPVNGTSQGKFQG 3789
Query: 993 LDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERG 1052
LDL ELY+GG + +PK S GF GC+ + + G +++ L+
Sbjct: 3790 LDLNEELYLGGYPD--YGAIPKAGLS-SGFIGCVRELRIQGE--EIVFHDLNLTAHGISH 3844
Query: 1053 CDGPSTTCTEESCANQGVCL-QQWDGFTCDCTMTSYGGPVCNDPGTTYIFGKG-GALITY 1110
C TC + C N G C + + C C + G C + + G T
Sbjct: 3845 C----PTCRDRPCQNGGQCHDSESSSYVCVCP-AGFTGSRCEHSQALHCHPEACGPDATC 3899
Query: 1111 TWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQL 1153
P+ R T L V V S SG G YL L
Sbjct: 3900 VNRPDGRGYTCRCHLGRS-GLRCEEGVTVTTPSLSGAGSYLAL 3941
Score = 57.8 bits (138), Expect = 9e-08
Identities = 39/142 (27%), Positives = 71/142 (50%), Gaps = 18/142 (12%)
Query: 905 QFKTTAPDGLLLFN------SGNGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVND 958
+ +T+ GLLL+ +G G DFI + L G++ + + LG+G + + S+ P+ND
Sbjct: 4233 EVRTSTASGLLLWQGVEVGEAGQGKDFISLGLQDGHLVFRYQLGSGEARLV--SEDPIND 4290
Query: 959 NQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGARN--LDLKGELYIGGLSKNMFSNLPKLV 1016
+WH V R+ G ++++D + + N ++ KG +YIGG ++ L
Sbjct: 4291 GEWHRVTALRE-GRRGSIQVDGEELVSGRSPGPNVAVNAKGSVYIGGA-----PDVATLT 4344
Query: 1017 ASR--DGFQGCLASVDLNGRLP 1036
R G GC+ ++ L+ P
Sbjct: 4345 GGRFSSGITGCVKNLVLHSARP 4366
Score = 56.2 bits (134), Expect = 3e-07
Identities = 97/398 (24%), Positives = 150/398 (37%), Gaps = 53/398 (13%)
Query: 76 DFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDRWHMVLLTRDARRTALAVDGEARA- 134
DF+ LV GR RF AT++ TP+A +H V L R + +L V A
Sbjct: 3722 DFISFGLVGGRPEFRFDAGSGM-ATIRHPTPLALGHFHTVTLLRSLTQGSLIVGDLAPVN 3780
Query: 135 AEVRSKRREMQVASDLFVGGIPPDVRLSALTLSTVKYEPPFRGLLANLKL-GERPPALLG 193
+ K + + + +L++GG P + LS+ F G + L++ GE
Sbjct: 3781 GTSQGKFQGLDLNEELYLGGYPDYGAIPKAGLSS-----GFIGCVRELRIQGEEIVFHDL 3835
Query: 194 SQGLRGATADPLCAPARNPCANGGLCTVLAPGEVGCDCSHTGFGGKFCSEEE----HPME 249
+ G + P C PC NGG C C C GF G C + HP
Sbjct: 3836 NLTAHGISHCPTCRD--RPCQNGGQCHDSESSSYVCVCP-AGFTGSRCEHSQALHCHPEA 3892
Query: 250 -GP----------------AHLTLNSEGKEEFVATFKGNEFFCYDLSHNPIQSSTD---E 289
GP HL + EE V + P ++T
Sbjct: 3893 CGPDATCVNRPDGRGYTCRCHLGRSGLRCEEGVTVTTPSLSGAGSYLALPALTNTHHELR 3952
Query: 290 ITLAFRTLQRNGLMLHTGKSA----DYVNLSLKSGAVWLVINLGSG-AFEALVEPVNGKF 344
+ + F+ L +G++L +G + D+V+L++ G + LGSG A EP+
Sbjct: 3953 LDVEFKPLAPDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLRSAEPL---- 4008
Query: 345 NDNAWHDVRVTRNLRQHAGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYIGG-SPN 403
WH V R + G V + ++ G +Q L Y+GG P+
Sbjct: 4009 ALGRWHRVSAERLNKD----GSLRVNGGRPVLRSSPGKSQG----LNLHTLLYLGGVEPS 4060
Query: 404 TADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEG 441
P + +S +F GC+ +V L S L +G
Sbjct: 4061 VPLSPATNMSAHFRGCVGEVSVNGKRLDLTYSFLGSQG 4098
Score = 54.3 bits (129), Expect = 1e-06
Identities = 50/169 (29%), Positives = 72/169 (42%), Gaps = 19/169 (11%)
Query: 53 LSFSLRTNATRALLLYL-----DDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPV 107
+ +RT+ LLL+ + G DF+ L L DG L R+ L E A L + P+
Sbjct: 4230 IELEVRTSTASGLLLWQGVEVGEAGQGKDFISLGLQDGHLVFRYQLGSGE-ARLVSEDPI 4288
Query: 108 ADDRWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQV--ASDLFVGGIPPDVRLSALT 165
D WH V R+ RR ++ VDGE RS + V +++GG P T
Sbjct: 4289 NDGEWHRVTALREGRRGSIQVDGE-ELVSGRSPGPNVAVNAKGSVYIGGAP-----DVAT 4342
Query: 166 LSTVKYEPPFRGLLANLKL-----GERPPALLGSQGLRGATADPLCAPA 209
L+ ++ G + NL L G PP L Q A A+ P+
Sbjct: 4343 LTGGRFSSGITGCVKNLVLHSARPGAPPPQPLDLQHRAQAGANTRPCPS 4391
Score = 40.0 bits (92), Expect = 0.019
Identities = 33/148 (22%), Positives = 64/148 (43%), Gaps = 24/148 (16%)
Query: 289 EITLAFRTLQRNGLMLHTG-------------KSADYVNLSLKSGAVWLVINLGSGAFEA 335
EI + FR +G++L+ G + D+++ L G + GSG
Sbjct: 3687 EIKITFRPDSADGMLLYNGQKRVPGSPTNLANRQPDFISFGLVGGRPEFRFDAGSG-MAT 3745
Query: 336 LVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDF 395
+ P +H V + R+L Q + I V + G +Q + L ++
Sbjct: 3746 IRHPTPLALGH--FHTVTLLRSLTQGSLI--------VGDLAPVNGTSQGKFQGLDLNEE 3795
Query: 396 FYIGGSPNTADLPGSPVSNNFMGCLKDV 423
Y+GG P+ +P + +S+ F+GC++++
Sbjct: 3796 LYLGGYPDYGAIPKAGLSSGFIGCVREL 3823
>gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]
Length = 3144
Score = 90.9 bits (224), Expect = 9e-18
Identities = 98/462 (21%), Positives = 180/462 (38%), Gaps = 81/462 (17%)
Query: 449 GDLSFRCEDVAALDPVTFESPE-AFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRA 507
G CE ++ +F S E ++++ + ++ I L F+ +G+L +
Sbjct: 2682 GTTGIYCEQALSISDPSFRSNELSWMSFASFHVRKKTHIQLQFQPLAADGILFY------ 2735
Query: 508 GGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSR-KVNDGEWCHVDFQRDG 566
A H AQ D+ + L++ + L ++G I L + +N W + R G
Sbjct: 2736 ---AAQHLKAQSGDFLCISLVNSSVQLRYNLGDRTIILETLQKVTINGSTWHIIKAGRVG 2792
Query: 567 RKGSISVNSRSTPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGC 626
+G + ++ + A+ LD ++ Y+GG+ ++L P + + G+ GC
Sbjct: 2793 AEGYLDLDGINVTEKASTKMSSLDTNTDFYIGGVSS---LNLVNPMAIENEPV--GFQGC 2847
Query: 627 VRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCREGWNRFICDCI 686
+R + I+ + L A+G V C C CRNGG C F C C+
Sbjct: 2848 IRQVIINNQELQLTEFG-AKGGSNVGD-CDGTA---CGYNTCRNGGECTVNGTTFSCRCL 2902
Query: 687 -------------------------------------GTGFLGRVCEREA--TVLSYDGS 707
G++GR CE + + + G+
Sbjct: 2903 PDWAGNTCNQSVSCLNNLCLHQSLCIPDQSFSYSCLCTLGWVGRYCENKTSFSTAKFMGN 2962
Query: 708 MYMKIMLPN--AMHTEAEDVSLRFMSQRAYGLM--MATTSRESADTLRLELDGGQMKLTV 763
Y+K + PN + + +SL F + + GL+ M E D L + L +K+ V
Sbjct: 2963 SYIKYIDPNYRMRNLQFTTISLNFSTTKTEGLIVWMGIAQNEENDFLAIGLHNQTLKIAV 3022
Query: 764 NLGKGPETLFAGHKLND-----NEWHTVRVVRRGKSLQLSVDNVTVEGQMAGAHMRLEFH 818
NLG E + N+ N+WH V V++ ++ ++N + + H
Sbjct: 3023 NLG---ERISVPMSYNNGTFCCNKWHHVVVIQNQTLIKAYINNSLILSEDIDPHKNFVAL 3079
Query: 819 NIE----TGIMTERRFISVV-----PSNFIGHLSGLVFNGQP 851
N + G R +++V +NF+G + +VF +P
Sbjct: 3080 NYDGICYLGGFEYGRKVNIVTQEIFKTNFVGKIKDVVFFQEP 3121
Score = 84.3 bits (207), Expect = 9e-16
Identities = 61/226 (26%), Positives = 99/226 (43%), Gaps = 16/226 (7%)
Query: 876 VADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNS----GNGNDFIVIELV 931
++DP + S+++ A+ H+ QF+ A DG+L + + DF+ I LV
Sbjct: 2694 ISDPSFRSNELSWMSFASFHVRKKTHIQLQFQPLAADGILFYAAQHLKAQSGDFLCISLV 2753
Query: 932 KGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQH-SNGA 990
+ ++LG+ +++ +N + WH + R G L +D VT+ S
Sbjct: 2754 NSSVQLRYNLGDRTIILETLQKVTINGSTWHIIKAGR-VGAEGYLDLDGINVTEKASTKM 2812
Query: 991 RNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNG---RLPDLIADALHRIG 1047
+LD + YIGG+S N + GFQGC+ V +N +L + A +G
Sbjct: 2813 SSLDTNTDFYIGGVSSLNLVNPMAIENEPVGFQGCIRQVIINNQELQLTEFGAKGGSNVG 2872
Query: 1048 QVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCN 1093
CDG T C +C N G C F+C C + + G CN
Sbjct: 2873 D----CDG--TACGYNTCRNGGECTVNGTTFSCRC-LPDWAGNTCN 2911
Score = 68.6 bits (166), Expect = 5e-11
Identities = 92/417 (22%), Positives = 170/417 (40%), Gaps = 78/417 (18%)
Query: 878 DPVTFKSRSSYLALATLQAYASMHLFFQFKT--TAPDGLLLFNSG------NGNDFIVIE 929
D + S +Y ++ + + HL FQ +A L+F +G NG+DF+ +
Sbjct: 2422 DAFGYTSFLAYSRISDISFHYEFHLKFQLANNHSALQNNLIFFTGQKGHGLNGDDFLAVG 2481
Query: 930 LVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNG 989
L+ G + Y ++LG+G + ++ +P+N + + V LK+D
Sbjct: 2482 LLNGSVVYSYNLGSGIASIR---SEPLNLSLGVHTVHLGKFFQEGWLKVDDHKNKSIIAP 2538
Query: 990 AR--NLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRL---------PDL 1038
R L++ + Y+GG S+ LP ++GFQGC+ ++ + P+
Sbjct: 2539 GRLVGLNVFSQFYVGGYSEYTPDLLPNGADFKNGFQGCIFTLQVRTEKDGHFRGLGNPEG 2598
Query: 1039 IADALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVC------ 1092
+A +GQ ++ C+ C N G C++ C+CT T + G C
Sbjct: 2599 HPNAGRSVGQCH------ASPCSLMKCGNGGTCIESGTSVYCNCT-TGWKGSFCTETVST 2651
Query: 1093 ----NDP------GTTYI-----------FGKGGALITYTWPPNDRPSTRMDRLA-VGF- 1129
+DP G T I G G +D PS R + L+ + F
Sbjct: 2652 CDPEHDPPHHCSRGATCISLPHGYTCFCPLGTTGIYCEQALSISD-PSFRSNELSWMSFA 2710
Query: 1130 STHQRSAVLVRVD----SASGL------------GDYLQLHIDQGTVGVIFNVGTDDITI 1173
S H R +++ +A G+ GD+L + + +V + +N+G I +
Sbjct: 2711 SFHVRKKTHIQLQFQPLAADGILFYAAQHLKAQSGDFLCISLVNSSVQLRYNLGDRTIIL 2770
Query: 1174 DEPNAIVSDGK-YHVVRFTRSGGNATLQVDSWPVNERYPAGRQLTIFNSQAAIKIGG 1229
+ + +G +H+++ R G L +D V E+ A +++ ++ IGG
Sbjct: 2771 ETLQKVTINGSTWHIIKAGRVGAEGYLDLDGINVTEK--ASTKMSSLDTNTDFYIGG 2825
Score = 68.2 bits (165), Expect = 6e-11
Identities = 95/402 (23%), Positives = 161/402 (40%), Gaps = 58/402 (14%)
Query: 76 DFLELLLVDGRLRLRFTLSCAEPATLQLDT----PVADDRWHMVLLTRDARRTALAVDGE 131
DFL + LV+ ++LR+ L T+ L+T + WH++ R L +DG
Sbjct: 2746 DFLCISLVNSSVQLRYNLG---DRTIILETLQKVTINGSTWHIIKAGRVGAEGYLDLDGI 2802
Query: 132 ARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLSTVKYEPP-FRGLLANLKLGERPPA 190
+ +K + +D ++GG+ L+ + ++ EP F+G + + + +
Sbjct: 2803 NVTEKASTKMSSLDTNTDFYIGGVSS---LNLVNPMAIENEPVGFQGCIRQVIINNQELQ 2859
Query: 191 L--LGSQGLRGATADPLCAPARNPCANGGLCTVLAPGEVGCDCSHTGFGGKFCSEEEHPM 248
L G++G A N C NGG CTV C C + G C++ +
Sbjct: 2860 LTEFGAKGGSNVGDCDGTACGYNTCRNGGECTVNGT-TFSCRCL-PDWAGNTCNQSVSCL 2917
Query: 249 EGPA-HLTL--------------------NSEGKEEF-VATFKGNEFFCY-DLSHNPIQS 285
H +L E K F A F GN + Y D ++
Sbjct: 2918 NNLCLHQSLCIPDQSFSYSCLCTLGWVGRYCENKTSFSTAKFMGNSYIKYIDPNYRMRNL 2977
Query: 286 STDEITLAFRTLQRNGLMLHTG----KSADYVNLSLKSGAVWLVINLGSGAFEALVEPV- 340
I+L F T + GL++ G + D++ + L + + + +NLG E + P+
Sbjct: 2978 QFTTISLNFSTTKTEGLIVWMGIAQNEENDFLAIGLHNQTLKIAVNLG----ERISVPMS 3033
Query: 341 --NGKFNDNAWHDVRVTRNLRQHAGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYI 398
NG F N WH V V +N + A + S+ IL+ +++ L D Y+
Sbjct: 3034 YNNGTFCCNKWHHVVVIQNQT----LIKAYINNSL--ILSEDIDPHKNFVALNYDGICYL 3087
Query: 399 GG---SPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRL 437
GG + NF+G +KDVV+ +EL +L
Sbjct: 3088 GGFEYGRKVNIVTQEIFKTNFVGKIKDVVFFQEPKNIELIKL 3129
Score = 55.5 bits (132), Expect = 4e-07
Identities = 44/203 (21%), Positives = 91/203 (44%), Gaps = 19/203 (9%)
Query: 902 LFFQFKTTAPDGLLLFNSGN--GNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDN 959
++ KT + +G +L+++GN G F+ + LV+G + GN +++ +++ +N N
Sbjct: 2175 IYLTIKTNSLNGTILYSNGNNCGKQFLHLFLVEGRPSVKYGCGNSQNILTVSANYSINTN 2234
Query: 960 QWHNVVVSR-----DPGNVHTLKI--DSRTVTQHSNGARNLDLKG---ELYIGGLSKNMF 1009
+ + + PG V +++ D + Q + + + +++G + N+
Sbjct: 2235 AFTPITIRYTTPVGSPGVVCMIEMTADGKPPVQKKDTEISHASQAYFESMFLGHIPANV- 2293
Query: 1010 SNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPSTTCTEESCANQG 1069
+ K GF+GC+ + +N + +I +A H G+ C P C C N G
Sbjct: 2294 -QIHKKAGPVYGFRGCILDLQVNNKEFFIIDEARH--GKNIENCHVP--WCAHHLCRNNG 2348
Query: 1070 VCLQQWDGFTCDCTMTSYGGPVC 1092
C+ + C+C Y G +C
Sbjct: 2349 TCISDNENLFCECPRL-YSGKLC 2370
Score = 55.1 bits (131), Expect = 6e-07
Identities = 87/410 (21%), Positives = 149/410 (36%), Gaps = 72/410 (17%)
Query: 499 LLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWC 558
L+F G++ G G D+ A+ LL+G + ++GSG +R+ ++ G
Sbjct: 2461 LIFFTGQKGHGLNGD-------DFLAVGLLNGSVVYSYNLGSGIASIRSEPLNLSLGVHT 2513
Query: 559 HVDFQRDGRKGSISVNS-RSTPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTA 617
V + ++G + V+ ++ +A G L++ S+ Y+GG E LP A
Sbjct: 2514 -VHLGKFFQEGWLKVDDHKNKSIIAPGRLVGLNVFSQFYVGGYSEYTPDLLPNG-----A 2567
Query: 618 ALRAGYVGCVRDLFI-DGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCRE 676
+ G+ GC+ L + + RGL +G + C+ C NGG C E
Sbjct: 2568 DFKNGFQGCIFTLQVRTEKDGHFRGLGNPEGHPNAGRSVGQCHASPCSLMKCGNGGTCIE 2627
Query: 677 GWNRFICDCIGTGFLGRV-----------------CEREATVLSYDG------------- 706
C+C TG+ G C R AT +S
Sbjct: 2628 SGTSVYCNCT-TGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPHGYTCFCPLGTTGI 2686
Query: 707 --SMYMKIMLPNAMHTEAE-------------DVSLRFMSQRAYGLMMATTSR---ESAD 748
+ I P+ E + L+F A G++ +S D
Sbjct: 2687 YCEQALSISDPSFRSNELSWMSFASFHVRKKTHIQLQFQPLAADGILFYAAQHLKAQSGD 2746
Query: 749 TLRLELDGGQMKLTVNLGKGPETLFAGHK--LNDNEWHTVRVVRRGKSLQLSVDNVTV-- 804
L + L ++L NLG L K +N + WH ++ R G L +D + V
Sbjct: 2747 FLCISLVNSSVQLRYNLGDRTIILETLQKVTINGSTWHIIKAGRVGAEGYLDLDGINVTE 2806
Query: 805 --EGQMAGAHMRLEFH--NIETGIMTERRFISVVPSNFIGHLSGLVFNGQ 850
+M+ +F+ + + + I P F G + ++ N Q
Sbjct: 2807 KASTKMSSLDTNTDFYIGGVSSLNLVNPMAIENEPVGFQGCIRQVIINNQ 2856
Score = 52.8 bits (125), Expect = 3e-06
Identities = 64/258 (24%), Positives = 107/258 (41%), Gaps = 54/258 (20%)
Query: 213 CANGGLCTVLAPGEVGCDCSHTGFGGKFCSEEEH---PMEGPAH---------------- 253
C NGG C + + V C+C+ TG+ G FC+E P P H
Sbjct: 2619 CGNGGTC-IESGTSVYCNCT-TGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPHGYT 2676
Query: 254 --LTLNSEGK--EEFVA----TFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLH 305
L + G E+ ++ +F+ NE + ++ T I L F+ L +G++ +
Sbjct: 2677 CFCPLGTTGIYCEQALSISDPSFRSNELSWMSFASFHVRKKT-HIQLQFQPLAADGILFY 2735
Query: 306 TGK-----SADYVNLSLKSGAVWLVINLGSGAFEALVEPVNG-KFNDNAWHDVRVTRNLR 359
+ S D++ +SL + +V L NLG ++E + N + WH ++
Sbjct: 2736 AAQHLKAQSGDFLCISLVNSSVQLRYNLGDRTI--ILETLQKVTINGSTWHIIK------ 2787
Query: 360 QHAGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYIGGSP-----NTADLPGSPVSN 414
AG A + +DGI T + L ++ FYIGG N + PV
Sbjct: 2788 --AGRVGAEGYLDLDGI-NVTEKASTKMSSLDTNTDFYIGGVSSLNLVNPMAIENEPVG- 2843
Query: 415 NFMGCLKDVVYKNNDFKL 432
F GC++ V+ N + +L
Sbjct: 2844 -FQGCIRQVIINNQELQL 2860
Score = 51.2 bits (121), Expect = 8e-06
Identities = 93/438 (21%), Positives = 154/438 (35%), Gaps = 111/438 (25%)
Query: 56 SLRTNATRALLLYLDDGGDC--DFLELLLVDGRLRLRFTLSCAE---------------- 97
+++TN+ +LY +G +C FL L LV+GR +++ ++
Sbjct: 2178 TIKTNSLNGTILY-SNGNNCGKQFLHLFLVEGRPSVKYGCGNSQNILTVSANYSINTNAF 2236
Query: 98 -PATLQLDTPVADDRWH-MVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVGGI 155
P T++ TPV M+ +T D + D E A +F+G I
Sbjct: 2237 TPITIRYTTPVGSPGVVCMIEMTADGKPPVQKKDTEISHAS-------QAYFESMFLGHI 2289
Query: 156 PPDVRLSALTLSTVKYEPP--FRGLLANLKLGERPPALLGSQGLRGATAD----PLCAP- 208
P +V++ K P FRG + +L++ + ++ + G + P CA
Sbjct: 2290 PANVQIHK------KAGPVYGFRGCILDLQVNNKEFFII-DEARHGKNIENCHVPWCAHH 2342
Query: 209 ---------------------------------ARNPCANGGLCTVLAPGEVGCDCSHTG 235
NPC NG C + ++ C C + G
Sbjct: 2343 LCRNNGTCISDNENLFCECPRLYSGKLCQFASCENNPCGNGATCVPKSGTDIVCLCPY-G 2401
Query: 236 FGGKFCSEEEHPMEGPAHLTLNSEGKEEFVATFKGNEFFCYDLSHNPIQSSTDEITLAFR 295
G C++ + + P ++ G F+A + ++ + H Q + + L
Sbjct: 2402 RSGPLCTDAINITQ-PRFSGTDAFGYTSFLAYSRISDISFHYEFHLKFQLANNHSALQNN 2460
Query: 296 TLQRNGLMLHTGKSADYVNLSLKSGAVWLVINLGSGAFEALVEPVN----------GKFN 345
+ G H D++ + L +G+V NLGSG EP+N GKF
Sbjct: 2461 LIFFTGQKGHGLNGDDFLAVGLLNGSVVYSYNLGSGIASIRSEPLNLSLGVHTVHLGKFF 2520
Query: 346 DNAWHDVRVTRNLRQHAGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYIGG-SPNT 404
W V H +I G L + FY+GG S T
Sbjct: 2521 QEGWLKVD-----------DHKNKSIIAPGRLVGLNVFSQ----------FYVGGYSEYT 2559
Query: 405 ADL--PGSPVSNNFMGCL 420
DL G+ N F GC+
Sbjct: 2560 PDLLPNGADFKNGFQGCI 2577
Score = 43.5 bits (101), Expect = 0.002
Identities = 19/40 (47%), Positives = 24/40 (60%), Gaps = 1/40 (2%)
Query: 660 LKQCASAPCRNGGVCREGWNRFICDCIGTGFLGRVCEREA 699
L +C S PC + GVC +G N + CDC +GF G CE A
Sbjct: 1005 LDECLSEPCLHDGVCIDGINHYTCDC-KSGFFGTHCETNA 1043
Score = 37.4 bits (85), Expect = 0.12
Identities = 12/26 (46%), Positives = 18/26 (69%)
Query: 660 LKQCASAPCRNGGVCREGWNRFICDC 685
+ +C+S PC+N G C + NRF C+C
Sbjct: 929 INECSSEPCKNNGTCVDLTNRFFCNC 954
Score = 37.0 bits (84), Expect = 0.16
Identities = 24/77 (31%), Positives = 32/77 (41%), Gaps = 17/77 (22%)
Query: 1025 CLASVDLNGRLPDLIADALHRIGQVERGCDGPSTT---------CTEESCANQGVCLQQW 1075
CL++ L+GR +LI + CD T+ CT C N+G C +
Sbjct: 1046 CLSNPCLHGRCTELI-------NEYPCSCDADGTSTQCKIKINDCTSIPCMNEGFCQKSA 1098
Query: 1076 DGFTCDCTMTSYGGPVC 1092
GFTC C Y G C
Sbjct: 1099 HGFTCICP-RGYTGAYC 1114
Score = 36.6 bits (83), Expect = 0.21
Identities = 47/226 (20%), Positives = 86/226 (38%), Gaps = 36/226 (15%)
Query: 482 RTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSG 541
RT +I L +T NG +L+S G G + + L++G + G+
Sbjct: 2171 RTVTIYLTIKTNSLNGTILYSNGNNCG-----------KQFLHLFLVEGRPSVKYGCGNS 2219
Query: 542 GIKLRASSR-KVNDGEWCHVDFQRDGRKGS------ISVNSRSTPFLATGDSEILDLES- 593
L S+ +N + + + GS I + + P + D+EI
Sbjct: 2220 QNILTVSANYSINTNAFTPITIRYTTPVGSPGVVCMIEMTADGKPPVQKKDTEISHASQA 2279
Query: 594 ---ELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVG 650
++LG +P ++ P G+ GC+ DL ++ + + + EA+
Sbjct: 2280 YFESMFLGHIPANVQIHKKAGPVY-------GFRGCILDLQVNNKEFFI--IDEARHGKN 2330
Query: 651 VAPFCSRETLKQCASAPCRNGGVCREGWNRFICDCIGTGFLGRVCE 696
+ C + CA CRN G C C+C + G++C+
Sbjct: 2331 IEN-CH---VPWCAHHLCRNNGTCISDNENLFCECPRL-YSGKLCQ 2371
Score = 36.2 bits (82), Expect = 0.27
Identities = 16/55 (29%), Positives = 27/55 (49%), Gaps = 2/55 (3%)
Query: 654 FCSRETLKQCASAPCRNGGVCREGWNRFICDCIGTGFLGRVCEREATVLSYDGSM 708
FC +E+ +C PC+N C + + + C+C +G+ G+ C E D M
Sbjct: 767 FCEQES-NECKMNPCKNNSTCTDLYKSYRCECT-SGWTGQNCSEEINECDSDPCM 819
Score = 36.2 bits (82), Expect = 0.27
Identities = 14/39 (35%), Positives = 23/39 (58%), Gaps = 1/39 (2%)
Query: 660 LKQCASAPCRNGGVCREGWNRFICDCIGTGFLGRVCERE 698
+ +C+S+PC +G C + N ++C C G+ G CE E
Sbjct: 1162 INECSSSPCLHGADCEDHINGYVCKC-QPGWSGHHCENE 1199
Score = 35.4 bits (80), Expect = 0.46
Identities = 32/131 (24%), Positives = 54/131 (41%), Gaps = 8/131 (6%)
Query: 906 FKTTAPDGLLLFNS---GNGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWH 962
F TT +GL+++ NDF+ I L + +LG S+ ++ N+WH
Sbjct: 2986 FSTTKTEGLIVWMGIAQNEENDFLAIGLHNQTLKIAVNLGERISVPMSYNNGTFCCNKWH 3045
Query: 963 NVVVSRD----PGNVHTLKIDSRTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVAS 1018
+VVV ++ ++ I S + H N L+ G Y+GG N+
Sbjct: 3046 HVVVIQNQTLIKAYINNSLILSEDIDPHKNFVA-LNYDGICYLGGFEYGRKVNIVTQEIF 3104
Query: 1019 RDGFQGCLASV 1029
+ F G + V
Sbjct: 3105 KTNFVGKIKDV 3115
Score = 34.7 bits (78), Expect = 0.78
Identities = 14/38 (36%), Positives = 20/38 (52%), Gaps = 1/38 (2%)
Query: 660 LKQCASAPCRNGGVCREGWNRFICDCIGTGFLGRVCER 697
+ C S PC N G C++ + F C C G+ G CE+
Sbjct: 1080 INDCTSIPCMNEGFCQKSAHGFTCIC-PRGYTGAYCEK 1116
Score = 34.3 bits (77), Expect = 1.0
Identities = 14/40 (35%), Positives = 19/40 (47%), Gaps = 1/40 (2%)
Query: 1053 CDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVC 1092
C+ C+ E C N G C+ + F C+C Y GP C
Sbjct: 925 CEIEINECSSEPCKNNGTCVDLTNRFFCNCE-PEYHGPFC 963
Score = 33.9 bits (76), Expect = 1.3
Identities = 14/52 (26%), Positives = 24/52 (46%), Gaps = 13/52 (25%)
Query: 660 LKQCASAPCRNGGVCREGWNRFICDCI-------------GTGFLGRVCERE 698
+ +CAS PC+NG C + + C C+ G++G CE++
Sbjct: 682 IDECASHPCKNGATCIDQPGNYFCQCVPPFKVVDGFSCLCNPGYVGIRCEQD 733
Score = 33.9 bits (76), Expect = 1.3
Identities = 15/33 (45%), Positives = 20/33 (60%), Gaps = 3/33 (9%)
Query: 655 CSRETLKQCASAPCRNGGVCREGW--NRFICDC 685
CS E + +C S PC NGG+C E +F+C C
Sbjct: 806 CSEE-INECDSDPCMNGGLCHESTIPGQFVCLC 837
Score = 32.3 bits (72), Expect = 3.9
Identities = 12/36 (33%), Positives = 18/36 (50%)
Query: 1053 CDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYG 1088
C+ C E C + GVC+ + +TCDC +G
Sbjct: 1001 CEINLDECLSEPCLHDGVCIDGINHYTCDCKSGFFG 1036
>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
Length = 4981
Score = 90.1 bits (222), Expect = 2e-17
Identities = 109/502 (21%), Positives = 198/502 (39%), Gaps = 95/502 (18%)
Query: 659 TLKQCASAPCRNGGVCREGWNRFICDCIGTGFLGRVCEREATVLSYDGSMYMKIMLPNAM 718
++ C PC NGG C+ G + + C C G G+ CE + M + PN
Sbjct: 3938 SVNYCECNPCFNGGSCQSGVDSYYCHC-PFGVFGKHCELNSYGFEELSYMEFPSLDPNNN 3996
Query: 719 HTEAEDVSLRFMSQRAYGLMMATTSRESADT---LRLELDGGQMKLTVNLGKGPETLFAG 775
+ + ++F + +++ L++ ++ D L LE+ +++ + NLG G L
Sbjct: 3997 Y-----IYVKFATIKSHALLLYNYDNQTGDRAEFLALEIAEERLRFSYNLGSGTYKLTTM 4051
Query: 776 HKLNDNEWHTVRVVRRGKSLQLSVDNVTVEGQMAG-----------------AHMRLEFH 818
K++D +HTV R G + L+VD+ + E Q G R+
Sbjct: 4052 KKVSDGHFHTVIARRAGMAASLTVDSCS-ENQEPGYCTVSNVAVSDDWTLDVQPNRVTVG 4110
Query: 819 NIETGIMTERRFISVVPSNFIGHLSGLVFNGQP-----------YMDQCK--DGDIT--- 862
I + +R V +F+G + NG+P +DQC +G T
Sbjct: 4111 GIRSLEPILQRRGHVESHDFVGCIMEFAVNGRPLEPSQALAAQGILDQCPRLEGACTRSP 4170
Query: 863 ----------------YCE--LNARFGLRAIVAD---PVTFKSRSSY------------- 888
+C+ L ++ +++ D + K R Y
Sbjct: 4171 CQHGGTCMDYWSWQQCHCKEGLTGKYCEKSVTPDTALSLEGKGRLDYHMSQNEKREYLLR 4230
Query: 889 --LALATLQAYASMHLFFQFKTTAPDGLLLFNSGNGNDFIVIELVKGYIHYVFDLGNGPS 946
L A L+ + L +F+T + +G+L+ + N + +++ G +++ D G
Sbjct: 4231 QSLRGAMLEPFGVNSLEVKFRTRSENGVLIHIQESSN-YTTVKIKNGKVYFTSDAGIAGK 4289
Query: 947 LMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKID---SRTVTQHSNGARNLDLKGELYIGG 1003
+ + + V D WH ++ ++ G L +D +R + + LD+ + +GG
Sbjct: 4290 VERNIPEVYVADGHWHTFLIGKN-GTATVLSVDRIYNRDIIHPTQDFGGLDVL-TISLGG 4347
Query: 1004 LSKNMFSNLPKLVASRDGFQGCLASVDLNGR-LPDLIADALHRIGQ----VERGCDGPST 1058
+ N A GF GC+AS+ G LP +L I + V+ GC GP+
Sbjct: 4348 IPPNQAHR----DAQTAGFDGCIASMWYGGESLPFSGKHSLASISKTDPSVKIGCRGPN- 4402
Query: 1059 TCTEESCANQGVCLQQWDGFTC 1080
C C +C+ QW + C
Sbjct: 4403 ICASNPCWGDLLCINQWYAYRC 4424
Score = 79.3 bits (194), Expect = 3e-14
Identities = 83/360 (23%), Positives = 149/360 (41%), Gaps = 77/360 (21%)
Query: 486 ISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKL 545
I + F T + + LLL++ + G RA++ A+E+ + L ++GSG KL
Sbjct: 3998 IYVKFATIKSHALLLYNYDNQTG---------DRAEFLALEIAEERLRFSYNLGSGTYKL 4048
Query: 546 RASSRKVNDGEWCHVDFQRDGRKGSISVNSRS---------TPFLATGDSEILDLE-SEL 595
+ +KV+DG + V +R G S++V+S S +A D LD++ + +
Sbjct: 4049 -TTMKKVSDGHFHTVIARRAGMAASLTVDSCSENQEPGYCTVSNVAVSDDWTLDVQPNRV 4107
Query: 596 YLGG-------LPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGA 648
+GG L G V+ +VGC+ + ++GR + AQG
Sbjct: 4108 TVGGIRSLEPILQRRGHVE------------SHDFVGCIMEFAVNGRPLEPSQALAAQGI 4155
Query: 649 VGVAPFCSRETLKQCASAPCRNGGVCREGWNRFICDCIGTGFLGRVCEREA---TVLSYD 705
+ P C +PC++GG C + W+ C C G G+ CE+ T LS +
Sbjct: 4156 LDQCPRLEGA----CTRSPCQHGGTCMDYWSWQQCHC-KEGLTGKYCEKSVTPDTALSLE 4210
Query: 706 GSMYMKIMLPNAMHTE----------------AEDVSLRFMSQRAYGLMMATTSRESADT 749
G + + E + ++F ++ G+++ +ES++
Sbjct: 4211 GKGRLDYHMSQNEKREYLLRQSLRGAMLEPFGVNSLEVKFRTRSENGVLIHI--QESSNY 4268
Query: 750 LRLELDGGQMKLTVNLGKG-------PETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDNV 802
+++ G++ T + G PE A D WHT + + G + LSVD +
Sbjct: 4269 TTVKIKNGKVYFTSDAGIAGKVERNIPEVYVA-----DGHWHTFLIGKNGTATVLSVDRI 4323
Score = 75.1 bits (183), Expect = 5e-13
Identities = 104/447 (23%), Positives = 182/447 (40%), Gaps = 70/447 (15%)
Query: 863 YCELNARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFN---- 918
+CELN+ +G + SY+ +L + +++ +F T LLL+N
Sbjct: 3972 HCELNS-YGFEEL-----------SYMEFPSLDPNNN-YIYVKFATIKSHALLLYNYDNQ 4018
Query: 919 SGNGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKI 978
+G+ +F+ +E+ + + + ++LG+G K + K V+D +H V+ R G +L +
Sbjct: 4019 TGDRAEFLALEIAEERLRFSYNLGSGT--YKLTTMKKVSDGHFHTVIARR-AGMAASLTV 4075
Query: 979 DSRTVTQH------SNGARNLDLKGELYIGGLSKNMFSNLPKLVASRD-----GFQGCLA 1027
DS + Q SN A + D ++ ++ +L ++ R F GC+
Sbjct: 4076 DSCSENQEPGYCTVSNVAVSDDWTLDVQPNRVTVGGIRSLEPILQRRGHVESHDFVGCIM 4135
Query: 1028 SVDLNGRLPDLIADALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSY 1087
+NGR P + AL G +++ C CT C + G C+ W C C
Sbjct: 4136 EFAVNGR-PLEPSQALAAQGILDQ-CPRLEGACTRSPCQHGGTCMDYWSWQQCHC-KEGL 4192
Query: 1088 GGPVCNDPGT--TYIFGKGGALITYTWPPND------RPSTR--------MDRLAVGFST 1131
G C T T + +G + Y N+ R S R ++ L V F T
Sbjct: 4193 TGKYCEKSVTPDTALSLEGKGRLDYHMSQNEKREYLLRQSLRGAMLEPFGVNSLEVKFRT 4252
Query: 1132 HQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNVG-TDDITIDEPNAIVSDGKYHVVRF 1190
+ VL+ + +S +Y + I G V + G + + P V+DG +H
Sbjct: 4253 RSENGVLIHIQESS---NYTTVKIKNGKVYFTSDAGIAGKVERNIPEVYVADGHWHTFLI 4309
Query: 1191 TRSGGNATLQVDS-------WPVNERYPAGRQLTIFNSQAAIKIGGRD-QGRPFQGQVSG 1242
++G L VD P + + LTI RD Q F G ++
Sbjct: 4310 GKNGTATVLSVDRIYNRDIIHPTQD-FGGLDVLTISLGGIPPNQAHRDAQTAGFDGCIAS 4368
Query: 1243 LYYNGLKV-------LALAAESDPNVR 1262
++Y G + LA +++DP+V+
Sbjct: 4369 MWYGGESLPFSGKHSLASISKTDPSVK 4395
Score = 65.9 bits (159), Expect = 3e-10
Identities = 104/420 (24%), Positives = 164/420 (39%), Gaps = 58/420 (13%)
Query: 59 TNATRALLLYLDD---GGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDT--PVADDRWH 113
T + ALLLY D G +FL L + + RLR + L T +L T V+D +H
Sbjct: 4004 TIKSHALLLYNYDNQTGDRAEFLALEIAEERLRFSYNLGSG---TYKLTTMKKVSDGHFH 4060
Query: 114 MVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLSTVKYEP 173
V+ R +L VD + E SD + DV+ + +T+ ++
Sbjct: 4061 TVIARRAGMAASLTVDSCSENQEPGYCTVSNVAVSDDWT----LDVQPNRVTVGGIRSLE 4116
Query: 174 P------------FRGLLANLKLGERP---PALLGSQGLRGATADPLCAPARNPCANGGL 218
P F G + + RP L +QG+ A R+PC +GG
Sbjct: 4117 PILQRRGHVESHDFVGCIMEFAVNGRPLEPSQALAAQGILDQCPRLEGACTRSPCQHGGT 4176
Query: 219 CTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEGKEEFVATFKGNEFFCYDL 278
C + C C G GK+C + P L+ EGK NE Y L
Sbjct: 4177 CMDYWSWQQ-CHCKE-GLTGKYCEKSVTP-----DTALSLEGKGRLDYHMSQNEKREYLL 4229
Query: 279 SHNPIQS-----STDEITLAFRTLQRNGLMLHTGKSADYVNLSLKSGAVWLVINLG-SGA 332
+ + + + + FRT NG+++H +S++Y + +K+G V+ + G +G
Sbjct: 4230 RQSLRGAMLEPFGVNSLEVKFRTRSENGVLIHIQESSNYTTVKIKNGKVYFTSDAGIAGK 4289
Query: 333 FEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVTISVDGILT-TTGYTQEDYTMLG 391
E + V D WH + +N G A V +SVD I + +D+ L
Sbjct: 4290 VERNIPEV--YVADGHWHTFLIGKN-------GTATV-LSVDRIYNRDIIHPTQDFGGLD 4339
Query: 392 SDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDF----KLELSRLAKEGDPKMKL 447
G PN A + F GC+ + Y K L+ ++K DP +K+
Sbjct: 4340 VLTISLGGIPPNQAHRDAQ--TAGFDGCIASMWYGGESLPFSGKHSLASISKT-DPSVKI 4396
Score = 57.4 bits (137), Expect = 1e-07
Identities = 127/568 (22%), Positives = 210/568 (36%), Gaps = 131/568 (23%)
Query: 211 NPCANGGLCTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEGKEEFVATFKG 270
NPC NGG C C C FG H LNS G EE
Sbjct: 3945 NPCFNGGSCQ-SGVDSYYCHCPFGVFG--------------KHCELNSYGFEE----LSY 3985
Query: 271 NEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLH-----TGKSADYVNLSLKSGAVWLV 325
EF D ++N I + F T++ + L+L+ TG A+++ L + +
Sbjct: 3986 MEFPSLDPNNN-------YIYVKFATIKSHALLLYNYDNQTGDRAEFLALEIAEERLRFS 4038
Query: 326 INLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVTISVD-----GILTTT 380
NLGSG ++ K +D +H V + + AG+ ++ S G T +
Sbjct: 4039 YNLGSGTYKLTTMK---KVSDGHFHTV-----IARRAGMAASLTVDSCSENQEPGYCTVS 4090
Query: 381 GY-TQEDYTMLGSDDFFYIGGSPNTADL---PGSPVSNNFMGCLKDVVYKNNDFKLELSR 436
+D+T+ + +GG + + G S++F+GC+ + + N LE S+
Sbjct: 4091 NVAVSDDWTLDVQPNRVTVGGIRSLEPILQRRGHVESHDFVGCIME--FAVNGRPLEPSQ 4148
Query: 437 -LAKEG--DPKMKLQGDLS-------------FRCEDVAALDPVTFESPEAFVALPRWSA 480
LA +G D +L+G + + + + +T + E V P +
Sbjct: 4149 ALAAQGILDQCPRLEGACTRSPCQHGGTCMDYWSWQQCHCKEGLTGKYCEKSVT-PDTAL 4207
Query: 481 KRTGSISLDFRTT------------------EPNGL--LLFSQGRRAGGGAGSHSSAQRA 520
G LD+ + EP G+ L R+ G H + +
Sbjct: 4208 SLEGKGRLDYHMSQNEKREYLLRQSLRGAMLEPFGVNSLEVKFRTRSENGVLIHIQ-ESS 4266
Query: 521 DYFAMELLDGHLYLLLDMG-SGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNS--RS 577
+Y +++ +G +Y D G +G ++ V DG W ++G +SV+
Sbjct: 4267 NYTTVKIKNGKVYFTSDAGIAGKVERNIPEVYVADGHWHTFLIGKNGTATVLSVDRIYNR 4326
Query: 578 TPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRS- 636
T D LD+ + + LGG+P P + A AG+ GC+ ++ G S
Sbjct: 4327 DIIHPTQDFGGLDVLT-ISLGGIP---------PNQAHRDAQTAGFDGCIASMWYGGESL 4376
Query: 637 -----RDLRGLAEAQGAVGVA----PFCSRETL------------------KQCASAPCR 669
L +++ +V + C+ CAS PC+
Sbjct: 4377 PFSGKHSLASISKTDPSVKIGCRGPNICASNPCWGDLLCINQWYAYRCVPPGDCASHPCQ 4436
Query: 670 NGGVCREGWNR-FICDCIGTGFLGRVCE 696
NGG C G + F C C GR CE
Sbjct: 4437 NGGSCEPGLHSGFTCSC-PDSHTGRTCE 4463
Score = 45.4 bits (106), Expect = 4e-04
Identities = 52/213 (24%), Positives = 86/213 (40%), Gaps = 16/213 (7%)
Query: 1001 IGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALH---RIGQVERGCDGPS 1057
+GG S + RD CL S NG + + + + G + C+
Sbjct: 3881 VGGFSCSCPDGFTGRACERD-INECLQSPCKNGAICQNFPGSFNCVCKTGYTGKMCESSV 3939
Query: 1058 TTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALITYTWPPNDR 1117
C C N G C D + C C +G C + G ++Y P+
Sbjct: 3940 NYCECNPCFNGGSCQSGVDSYYCHCPFGVFGKH-CE------LNSYGFEELSYMEFPSLD 3992
Query: 1118 PSTRMDRLAVGFSTHQRSAVLV-RVDSASG-LGDYLQLHIDQGTVGVIFNVGTDDITIDE 1175
P+ + V F+T + A+L+ D+ +G ++L L I + + +N+G+ +
Sbjct: 3993 PNNNY--IYVKFATIKSHALLLYNYDNQTGDRAEFLALEIAEERLRFSYNLGSGTYKLTT 4050
Query: 1176 PNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNE 1208
VSDG +H V R+G A+L VDS N+
Sbjct: 4051 MKK-VSDGHFHTVIARRAGMAASLTVDSCSENQ 4082
Score = 39.3 bits (90), Expect = 0.032
Identities = 16/39 (41%), Positives = 21/39 (53%), Gaps = 1/39 (2%)
Query: 660 LKQCASAPCRNGGVCREGWNRFICDCIGTGFLGRVCERE 698
+ +C +PC +GG C F C C GF GR CER+
Sbjct: 3863 IDECLPSPCHSGGTCHNLVGGFSCSC-PDGFTGRACERD 3900
Score = 37.4 bits (85), Expect = 0.12
Identities = 59/257 (22%), Positives = 105/257 (40%), Gaps = 51/257 (19%)
Query: 53 LSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTP---VAD 109
L RT + +L+++ + + + + + +G++ FT ++ + P VAD
Sbjct: 4246 LEVKFRTRSENGVLIHIQESSN--YTTVKIKNGKVY--FTSDAGIAGKVERNIPEVYVAD 4301
Query: 110 DRWHMVLLTRDARRTALAVDGEARAAEVRSKRR--EMQVASDLFVGGIPPD-VRLSALT- 165
WH L+ ++ T L+VD + + + V + + +GGIPP+ A T
Sbjct: 4302 GHWHTFLIGKNGTATVLSVDRIYNRDIIHPTQDFGGLDVLT-ISLGGIPPNQAHRDAQTA 4360
Query: 166 -----LSTVKY---EPPFRGLLANLKLGERPPAL-LGSQGLRGATADPL----------- 205
++++ Y PF G + + + P++ +G +G ++P
Sbjct: 4361 GFDGCIASMWYGGESLPFSGKHSLASISKTDPSVKIGCRGPNICASNPCWGDLLCINQWY 4420
Query: 206 ---CAP----ARNPCANGGLCTVLAPGEVGCDC--SHTGFG--------GKFCSEEEHPM 248
C P A +PC NGG C C C SHTG G C + +
Sbjct: 4421 AYRCVPPGDCASHPCQNGGSCEPGLHSGFTCSCPDSHTGRTCEMVVACLGVLCPQGKVCK 4480
Query: 249 EG-PA-HLTLNSEGKEE 263
G PA H+ + S+G EE
Sbjct: 4481 AGSPAGHVCVLSQGPEE 4497
>gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo
sapiens]
Length = 3312
Score = 89.4 bits (220), Expect = 3e-17
Identities = 110/458 (24%), Positives = 176/458 (38%), Gaps = 104/458 (22%)
Query: 454 RCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGS 513
RCE A P P +FV + ++SL F T + +GLL ++ GR
Sbjct: 1512 RCEVAARSFP-----PSSFVMFRGLRQRFHLTLSLSFATVQQSGLLFYN-GRLN------ 1559
Query: 514 HSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRAS-SRKVNDGEWCHVDFQ------RDG 566
++ D+ A+EL+ G + L G + + ++DG+W V + D
Sbjct: 1560 ----EKHDFLALELVAGQVRLTYSTGESNTVVSPTVPGGLSDGQWHTVHLRYYNKPRTDA 1615
Query: 567 RKGSISVNSRSTPFLATGDSEI---------------------------LDLESELYLGG 599
G+ + L+ D ++ LDL L LGG
Sbjct: 1616 LGGAQGPSKDKVAVLSVDDCDVAVALQFGAEIGNYSCAAAGVQTSSKKSLDLTGPLLLGG 1675
Query: 600 LPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRET 659
+P PE + + + ++GC+RDL IDGR D+ G + +
Sbjct: 1676 VPN--------LPENFPVSHK-DFIGCMRDLHIDGRRVDMAAFVANNGTMAGC----QAK 1722
Query: 660 LKQCASAPCRNGGVCREGWNRFICDCIGTGFLGRVCE---------REATVLSYDGSMYM 710
L C S PC+N G C E W F CDC GF G+ C+ R LS++ M
Sbjct: 1723 LHFCDSGPCKNSGFCSERWGSFSCDC-PVGFGGKDCQLTMAHPHHFRGNGTLSWNFGSDM 1781
Query: 711 KIMLPNAMHTEAEDVSLRFMSQRAYGLMMATTSRESADTLRLELDGGQMKLTVNLGKG-- 768
+ +P + L F ++ G++M + + TL +LD G + +TV G G
Sbjct: 1782 AVSVPWYL-------GLAFRTRATQGVLMQVQAGPHS-TLLCQLDRGLLSVTVTRGSGRA 1833
Query: 769 PETLFAGHKLNDNEWHTVRVV-------RRGK-----SLQLSV--DNVTVEGQMAGAHMR 814
L ++D WH +R+ RRG SL S+ D + V ++ G ++
Sbjct: 1834 SHLLLDQVTVSDGRWHDLRLELQEEPGGRRGHHVLMVSLDFSLFQDTMAVGSELQGLKVK 1893
Query: 815 -LEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQP 851
L + G E P +G + G+ P
Sbjct: 1894 QLHVGGLPPGSAEE------APQGLVGCIQGVWLGSTP 1925
Score = 88.2 bits (217), Expect = 6e-17
Identities = 82/344 (23%), Positives = 139/344 (40%), Gaps = 54/344 (15%)
Query: 886 SSYLALATLQAYASMHLFFQFKTTAPDGLLLFNS--GNGNDFIVIELVKGYIHYVFDLGN 943
SS++ L+ + L F T GLL +N +DF+ +ELV G + + G
Sbjct: 1523 SSFVMFRGLRQRFHLTLSLSFATVQQSGLLFYNGRLNEKHDFLALELVAGQVRLTYSTGE 1582
Query: 944 GPSLMKGNSDKPVNDNQWHNVVV-----------------SRDPGNVHTLKIDSRTVTQ- 985
+++ ++D QWH V + S+D V L +D V
Sbjct: 1583 SNTVVSPTVPGGLSDGQWHTVHLRYYNKPRTDALGGAQGPSKD--KVAVLSVDDCDVAVA 1640
Query: 986 -----------------HSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLAS 1028
++ ++LDL G L +GG+ N+ N P S F GC+
Sbjct: 1641 LQFGAEIGNYSCAAAGVQTSSKKSLDLTGPLLLGGVP-NLPENFP---VSHKDFIGCMRD 1696
Query: 1029 VDLNGRLPDLIADALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYG 1088
+ ++GR D+ A + GC C C N G C ++W F+CDC + +G
Sbjct: 1697 LHIDGRRVDMAAFVANN--GTMAGCQAKLHFCDSGPCKNSGFCSERWGSFSCDCPV-GFG 1753
Query: 1089 GPVCNDPGTTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLG 1148
G C +G +++ + +D + L + F T VL++V +G
Sbjct: 1754 GKDCQLTMAHPHHFRGNGTLSWNF-GSDMAVSVPWYLGLAFRTRATQGVLMQVQ--AGPH 1810
Query: 1149 DYLQLHIDQGTVGVIFNVGT---DDITIDEPNAIVSDGKYHVVR 1189
L +D+G + V G+ + +D+ VSDG++H +R
Sbjct: 1811 STLLCQLDRGLLSVTVTRGSGRASHLLLDQ--VTVSDGRWHDLR 1852
Score = 76.6 bits (187), Expect = 2e-13
Identities = 138/560 (24%), Positives = 205/560 (36%), Gaps = 127/560 (22%)
Query: 206 CAPARNPCANGGLCTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGP-AHLTLNSEGKEEF 264
C P C NGG CT G C C GG F EGP + S F
Sbjct: 1479 CVPG--VCRNGGTCTDAPNGGFRCQCPA---GGAF--------EGPRCEVAARSFPPSSF 1525
Query: 265 VATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHTGK---SADYVNLSLKSGA 321
V F+G Q ++L+F T+Q++GL+ + G+ D++ L L +G
Sbjct: 1526 VM-FRGLR-----------QRFHLTLSLSFATVQQSGLLFYNGRLNEKHDFLALELVAGQ 1573
Query: 322 VWLVINLGSGAFEALVEP-VNGKFNDNAWHDVRVTR-NLRQHAGIGHA-------MVTIS 372
V L + G +V P V G +D WH V + N + +G A + +S
Sbjct: 1574 VRLTYSTGES--NTVVSPTVPGGLSDGQWHTVHLRYYNKPRTDALGGAQGPSKDKVAVLS 1631
Query: 373 VDGI----------------LTTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVSN-N 415
VD G L +GG PN + PVS+ +
Sbjct: 1632 VDDCDVAVALQFGAEIGNYSCAAAGVQTSSKKSLDLTGPLLLGGVPNLPE--NFPVSHKD 1689
Query: 416 FMGCLKDV------------VYKNNDFKLELSRLAKEGDPKMKLQGDLSFRCEDVAALDP 463
F+GC++D+ V N ++L K G S R + P
Sbjct: 1690 FIGCMRDLHIDGRRVDMAAFVANNGTMAGCQAKLHFCDSGPCKNSGFCSERWGSFSCDCP 1749
Query: 464 VTFESPEAFVALPR-----------WSAKRTGSIS------LDFRTTEPNGLLLFSQGRR 506
V F + + + W+ ++S L FRT G+L+ Q
Sbjct: 1750 VGFGGKDCQLTMAHPHHFRGNGTLSWNFGSDMAVSVPWYLGLAFRTRATQGVLMQVQ--- 1806
Query: 507 AGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIK-LRASSRKVNDGEW--CHVDFQ 563
AG HS+ +L G L + + GSG L V+DG W ++ Q
Sbjct: 1807 ----AGPHST------LLCQLDRGLLSVTVTRGSGRASHLLLDQVTVSDGRWHDLRLELQ 1856
Query: 564 RD--GRKGS----ISVN-SRSTPFLATGDSEILDLE-SELYLGGLPEGGRVDLPLPPEVW 615
+ GR+G +S++ S +A G SE+ L+ +L++GGLP G + P
Sbjct: 1857 EEPGGRRGHHVLMVSLDFSLFQDTMAVG-SELQGLKVKQLHVGGLPPGSAEEAP------ 1909
Query: 616 TAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCR 675
G VGC++ +++ L V P C CAS PC CR
Sbjct: 1910 -----QGLVGCIQGVWLGSTPSGSPALLPPSHRVNAEPGCV--VTNACASGPCPPHADCR 1962
Query: 676 EGWNRFICDCIGTGFLGRVC 695
+ W F C C G+ G C
Sbjct: 1963 DLWQTFSCTC-QPGYYGPGC 1981
Score = 62.0 bits (149), Expect = 5e-09
Identities = 105/421 (24%), Positives = 159/421 (37%), Gaps = 90/421 (21%)
Query: 53 LSFSLRTNATRALLLYLDDGGDC-DFLELLLVDGRLRLRFTLSCAEPATLQLDTP---VA 108
LS S T LL Y + DFL L LV G++RL T S E T+ T ++
Sbjct: 1539 LSLSFATVQQSGLLFYNGRLNEKHDFLALELVAGQVRL--TYSTGESNTVVSPTVPGGLS 1596
Query: 109 DDRWHMV-------------------------LLTRDARRTALAVDGEAR-------AAE 136
D +WH V +L+ D A+A+ A AA
Sbjct: 1597 DGQWHTVHLRYYNKPRTDALGGAQGPSKDKVAVLSVDDCDVAVALQFGAEIGNYSCAAAG 1656
Query: 137 VR-SKRREMQVASDLFVGGIPPDVRLSALTLSTVKYEPPFRGLLANLKLGERP---PALL 192
V+ S ++ + + L +GG+P L + F G + +L + R A +
Sbjct: 1657 VQTSSKKSLDLTGPLLLGGVPN------LPENFPVSHKDFIGCMRDLHIDGRRVDMAAFV 1710
Query: 193 GSQGLRGATADPLCAPARNPCANGGLCTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPA 252
+ G L PC N G C+ G CDC GFGGK C + M P
Sbjct: 1711 ANNGTMAGCQAKLHFCDSGPCKNSGFCSERW-GSFSCDCP-VGFGGKDC---QLTMAHPH 1765
Query: 253 HLTLNSEGKEEFVATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHTGKSADY 312
H F+GN ++ + S + LAFRT G+++
Sbjct: 1766 H--------------FRGNGTLSWNFGSDMAVSVPWYLGLAFRTRATQGVLMQVQAGPHS 1811
Query: 313 VNL-SLKSGAVWLVINLGSG-AFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVT 370
L L G + + + GSG A L++ V +D WHD+R+ GH ++
Sbjct: 1812 TLLCQLDRGLLSVTVTRGSGRASHLLLDQVT--VSDGRWHDLRLELQEEPGGRRGHHVLM 1869
Query: 371 ISVDGILTTTGYTQEDYTMLGSD------DFFYIGGSPNTADLPGS--PVSNNFMGCLKD 422
+S+D L +D +GS+ ++GG P PGS +GC++
Sbjct: 1870 VSLDFSLF------QDTMAVGSELQGLKVKQLHVGGLP-----PGSAEEAPQGLVGCIQG 1918
Query: 423 V 423
V
Sbjct: 1919 V 1919
Score = 51.2 bits (121), Expect = 8e-06
Identities = 50/206 (24%), Positives = 81/206 (39%), Gaps = 22/206 (10%)
Query: 901 HLFFQFKTTAPDGLLLFNSGNGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQ 960
+L F+T A G+L+ + ++ +L +G + G+G + V+D +
Sbjct: 1788 YLGLAFRTRATQGVLMQVQAGPHSTLLCQLDRGLLSVTVTRGSGRASHLLLDQVTVSDGR 1847
Query: 961 WHNV--VVSRDPGNV---HTLKIDSRTVTQHSNGARNLDLKG----ELYIGGLSKNMFSN 1011
WH++ + +PG H L + A +L+G +L++GGL
Sbjct: 1848 WHDLRLELQEEPGGRRGHHVLMVSLDFSLFQDTMAVGSELQGLKVKQLHVGGLPPGSAEE 1907
Query: 1012 LPKLVASRDGFQGCLASVDLNGR---LPDLIADALHRIGQVERGCDGPSTTCTEESCANQ 1068
P+ G GC+ V L P L+ + HR+ E GC + C C
Sbjct: 1908 APQ------GLVGCIQGVWLGSTPSGSPALLPPS-HRVN-AEPGCV-VTNACASGPCPPH 1958
Query: 1069 GVCLQQWDGFTCDCTMTSYGGPVCND 1094
C W F+C C Y GP C D
Sbjct: 1959 ADCRDLWQTFSCTC-QPGYYGPGCVD 1983
Score = 50.1 bits (118), Expect = 2e-05
Identities = 44/134 (32%), Positives = 61/134 (45%), Gaps = 13/134 (9%)
Query: 662 QCASAPCRNGGVCREGWN-RFICDC-IGTGFLGRVCEREATVLSYDGSMYMKIMLPNAMH 719
+C CRNGG C + N F C C G F G CE A S+ S + +M
Sbjct: 1478 RCVPGVCRNGGTCTDAPNGGFRCQCPAGGAFEGPRCEVAAR--SFPPSSF--VMFRGLRQ 1533
Query: 720 TEAEDVSLRFMSQRAYGLMMAT-TSRESADTLRLELDGGQMKLTVNLGKG----PETLFA 774
+SL F + + GL+ E D L LEL GQ++LT + G+ T+
Sbjct: 1534 RFHLTLSLSFATVQQSGLLFYNGRLNEKHDFLALELVAGQVRLTYSTGESNTVVSPTVPG 1593
Query: 775 GHKLNDNEWHTVRV 788
G L+D +WHTV +
Sbjct: 1594 G--LSDGQWHTVHL 1605
Score = 40.4 bits (93), Expect = 0.014
Identities = 41/173 (23%), Positives = 68/173 (39%), Gaps = 38/173 (21%)
Query: 1053 CDGPSTTCTEESCANQGVCLQQWDGFTC---------DCTMTSYGG----PVCNDPGTTY 1099
C+ C C N G C ++ G+TC DC + + G VC + GT
Sbjct: 1432 CETELDLCYSNPCRNGGACARREGGYTCVCRPRFTGEDCELDTEAGRCVPGVCRNGGTCT 1491
Query: 1100 IFGKGG----------------ALITYTWPPNDRPSTRMDR------LAVGFSTHQRSAV 1137
GG + ++PP+ R R L++ F+T Q+S +
Sbjct: 1492 DAPNGGFRCQCPAGGAFEGPRCEVAARSFPPSSFVMFRGLRQRFHLTLSLSFATVQQSGL 1551
Query: 1138 LVRVDSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEPNAI--VSDGKYHVV 1188
L + D+L L + G V + ++ G + T+ P +SDG++H V
Sbjct: 1552 LFYNGRLNEKHDFLALELVAGQVRLTYSTGESN-TVVSPTVPGGLSDGQWHTV 1603
>gi|28559088 laminin alpha 2 subunit isoform a precursor [Homo
sapiens]
Length = 3122
Score = 89.0 bits (219), Expect = 3e-17
Identities = 154/776 (19%), Positives = 289/776 (37%), Gaps = 136/776 (17%)
Query: 516 SAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNS 575
SA+ D+ A+E+ G + L D+GSG ++ ++D W + R GR G+ISV +
Sbjct: 2188 SAKFIDFLAIEMRKGKVSFLWDVGSGVGRVEYPDLTIDDSYWYRIVASRTGRNGTISVRA 2247
Query: 576 RSTPFLATGDSE----------ILDLESE--LYLGGLPEGGRVDLPLPPEVWTAALRAGY 623
P + S ILD+++ L++GGL G++ V T +
Sbjct: 2248 LDGPKASIVPSTHHSTSPPGYTILDVDANAMLFVGGLT--GKLKKADAVRVIT------F 2299
Query: 624 VGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCREGWNRFIC 683
GC+ + + D + L E +G
Sbjct: 2300 TGCMGETYFDNKPIGLWNFREKEG------------------------------------ 2323
Query: 684 DCIGTGFLGRVCEREATVLSYDGSMYMKIMLPNAMHTEAEDVSLRFMSQRAYGLMMATTS 743
DC G +V + E T+ +DG Y + P + V +F + + L+M +
Sbjct: 2324 DCKGCTVSPQVEDSEGTI-QFDGEGYALVSRPIRWYPNISTVMFKFRTFSSSALLMYLAT 2382
Query: 744 RESADTLRLELDGGQMKLTVNLGKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDNV- 802
R+ D + +EL G +K++ +LG G ++ + ND +W + + R K +S+ ++
Sbjct: 2383 RDLRDFMSVELTDGHIKVSYDLGSGMASVVSNQNHNDGKWKSFTLSRIQKQANISIVDID 2442
Query: 803 ---------TVEGQMAGAHMRLEFHNIETGIMTERRFI-----SVVPSNFIGHLSGLVFN 848
+ G G ++ + G+ T R V + G L + +
Sbjct: 2443 TNQEENIATSSSGNNFGLDLKADDKIYFGGLPTLRNLSMKARPEVNLKKYSGCLKDIEIS 2502
Query: 849 GQPYMDQCKDGDITYCELNARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKT 908
PY Y + L + V+F + ++ L+ + + F T
Sbjct: 2503 RTPYNILSSP---DYVGVTKGCSLENVYT--VSF-PKPGFVELSPVPIDVGTEINLSFST 2556
Query: 909 TAPDGLLLFNSG------------NGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKP- 955
G++L SG G + VI L +G + L G M+ +P
Sbjct: 2557 KNESGIILLGSGGTPAPPRRKRRQTGQAYYVILLNRGRLE--VHLSTGARTMRKIVIRPE 2614
Query: 956 ---VNDNQWHNVVVSRDPGNVHTLKID-SRTVTQHSNGARNLDLKGELYIGGLSKNMFSN 1011
+D + H+V V R G + T+++D +R Q+ + +++K +L++GG
Sbjct: 2615 PNLFHDGREHSVHVERTRG-IFTVQVDENRRYMQNLTVEQPIEVK-KLFVGGAPPEF--- 2669
Query: 1012 LPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPSTTCTEESCANQGVC 1071
P + + F+GC+ ++ +N D + + R C E+ A +
Sbjct: 2670 QPSPLRNIPPFEGCIWNLVINSVPMDFARPVSFKNADIGR-CAHQKLREDEDGAAPAEIV 2728
Query: 1072 LQ----QWDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALITYTWPPNDRPSTRMDRLAV 1127
+Q F + ++G I K L +R +A+
Sbjct: 2729 IQPEPVPTPAFPTPTPVLTHGPCAAESEPALLIGSKQFGL------------SRNSHIAI 2776
Query: 1128 GFSTHQRSAVL-----VRVDSASGL---------GDYLQLHIDQGTVGVIFNVGTDDITI 1173
F + L VR ++ SGL D+ + + G +++G+ D
Sbjct: 2777 AFDDTKVKNRLTIELEVRTEAESGLLFYMARINHADFATVQLRNGLPYFSYDLGSGDTHT 2836
Query: 1174 DEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGRQLTIFNSQAAIKIGG 1229
P I +DG++H ++ RS L VD + R + ++ I + + +GG
Sbjct: 2837 MIPTKI-NDGQWHKIKIMRSKQEGILYVDG--ASNRTISPKKADILDVVGMLYVGG 2889
Score = 79.0 bits (193), Expect = 4e-14
Identities = 212/1049 (20%), Positives = 367/1049 (34%), Gaps = 187/1049 (17%)
Query: 49 SSGELSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVA 108
S + +++T LL YL DFL + + G++ + + D +
Sbjct: 2166 SYNNIVVNVKTAVADNLLFYLGSAKFIDFLAIEMRKGKVSFLWDVGSGVGRVEYPDLTID 2225
Query: 109 DDRWHMVLLTRDARRTALAV---DGEARAAEVRSKRR----------EMQVASDLFVGGI 155
D W+ ++ +R R ++V DG +A+ V S ++ + LFVGG+
Sbjct: 2226 DSYWYRIVASRTGRNGTISVRALDGP-KASIVPSTHHSTSPPGYTILDVDANAMLFVGGL 2284
Query: 156 PPDVRLS-ALTLSTVKYEPPFRGLLANLKLGERPPALLGSQGLRGATADPLCAPARNPCA 214
++ + A+ + T F G + +P L + G
Sbjct: 2285 TGKLKKADAVRVIT------FTGCMGETYFDNKPIGLWNFREKEG--------------- 2323
Query: 215 NGGLCTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEGKEEFVATFKGNEFF 274
DC K C+ + + + EG
Sbjct: 2324 ---------------DC-------KGCTVSPQVEDSEGTIQFDGEG-------------- 2347
Query: 275 CYDLSHNPIQ--SSTDEITLAFRTLQRNGLMLH--TGKSADYVNLSLKSGAVWLVINLGS 330
Y L PI+ + + FRT + L+++ T D++++ L G + + +LGS
Sbjct: 2348 -YALVSRPIRWYPNISTVMFKFRTFSSSALLMYLATRDLRDFMSVELTDGHIKVSYDLGS 2406
Query: 331 GAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVTISVDGILTTTGYTQEDYTML 390
G + N ND W ++R +++ A I + + + + T+ L
Sbjct: 2407 GMASVVS---NQNHNDGKWKSFTLSR-IQKQANISIVDIDTNQEENIATSSSGNNFGLDL 2462
Query: 391 GSDDFFYIGGSPNTADLP--GSPVSN--NFMGCLKDVVYKNNDFKLELSRLAKEGDPKMK 446
+DD Y GG P +L P N + GCLKD+ + + LS G K
Sbjct: 2463 KADDKIYFGGLPTLRNLSMKARPEVNLKKYSGCLKDIEISRTPYNI-LSSPDYVGVTK-- 2519
Query: 447 LQGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRR 506
E+V V+F P FV L I+L F T +G++L G
Sbjct: 2520 -----GCSLENVYT---VSFPKP-GFVELSPVPIDVGTEINLSFSTKNESGIILLGSGGT 2570
Query: 507 AGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDG 566
+A Y+ + L G L + L G+ ++ + N DG
Sbjct: 2571 PAPPRRKRRQTGQA-YYVILLNRGRLEVHLSTGARTMRKIVIRPEPN--------LFHDG 2621
Query: 567 RKGSISVNSRSTPFLATGDS-----EILDLESELYLGGLPEGGRVDLPLPPEVWTAALR- 620
R+ S+ V F D + L +E + + L GG PPE + LR
Sbjct: 2622 REHSVHVERTRGIFTVQVDENRRYMQNLTVEQPIEVKKLFVGGA-----PPEFQPSPLRN 2676
Query: 621 -AGYVGCVRDLFID-----------------GRSRDLRGLAEAQGAVGVAPFCSRETLKQ 662
+ GC+ +L I+ GR + + GA E +
Sbjct: 2677 IPPFEGCIWNLVINSVPMDFARPVSFKNADIGRCAHQKLREDEDGAAPAEIVIQPEPVPT 2736
Query: 663 CA---SAPCRNGGVCREGWNRFICDCIGTGFLGRVCEREATVLSYDGSMYMKIMLPNAMH 719
A P G C + IG+ G + D + ++ + +
Sbjct: 2737 PAFPTPTPVLTHGPCAAESEPALL--IGSKQFGLSRNSHIAIAFDDTKVKNRLTIELEVR 2794
Query: 720 TEAEDVSLRFMSQRAYGLMMATTSRESADTLRLELDGGQMKLTVNLGKGPETLFAGHKLN 779
TEAE GL+ AD ++L G + +LG G K+N
Sbjct: 2795 TEAES-----------GLLFYMARINHADFATVQLRNGLPYFSYDLGSGDTHTMIPTKIN 2843
Query: 780 DNEWHTVRVVRRGKSLQLSVD---NVTVEGQMAG---AHMRLEFHNIETGIMTERRFISV 833
D +WH ++++R + L VD N T+ + A L + T R I
Sbjct: 2844 DGQWHKIKIMRSKQEGILYVDGASNRTISPKKADILDVVGMLYVGGLPINYTTRR--IGP 2901
Query: 834 VPSNFIGHLSGLVFNGQPY-MDQCKDG-DITYCELNARFGLRAIVADPVTFKSRSSYLAL 891
V + G + L P ++Q + C NA+ G F A+
Sbjct: 2902 VTYSIDGCVRNLHMAEAPADLEQPTSSFHVGTCFANAQRG--------TYFDGTGFAKAV 2953
Query: 892 ATLQAYASMHLFFQFKTTAPDGLLLFNSGNGNDFIVIELVKGYIHYVFDLGNGPSLMKGN 951
+ + + F+F+TT G+LL S D + IE++ + + D G G +
Sbjct: 2954 GGFKVGLDLLVEFEFRTTTTTGVLLGISSQKMDGMGIEMIDEKLMFHVDNGAGRFTAVYD 3013
Query: 952 SDKP--VNDNQWHNVVVSRDPGNVHTLKIDSRTVTQHS--NGARNLDLKGELYIGGLSKN 1007
+ P + D QWH V ++ + L +D V S + + D +++GG +
Sbjct: 3014 AGVPGHLCDGQWHKVTANKIKHRIE-LTVDGNQVEAQSPNPASTSADTNDPVFVGGFPDD 3072
Query: 1008 -----MFSNLPKLVASRDGFQGCLASVDL 1031
+ +++P F+GC+ S+ L
Sbjct: 3073 LKQFGLTTSIP--------FRGCIRSLKL 3093
Score = 77.0 bits (188), Expect = 1e-13
Identities = 133/623 (21%), Positives = 234/623 (37%), Gaps = 129/623 (20%)
Query: 32 GGGPGQWARYARWAGAASSGELSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRF 91
G G +R RW S+ + F RT ++ ALL+YL DF+ + L DG +++ +
Sbjct: 2345 GEGYALVSRPIRWYPNIST--VMFKFRTFSSSALLMYLATRDLRDFMSVELTDGHIKVSY 2402
Query: 92 TLSCAEPATLQLDTPVADDRWHMVLLTRDARRTALAV--------DGEARAAEVRSKRRE 143
L A++ + D +W L+R ++ +++ + A ++ + +
Sbjct: 2403 DLGSGM-ASVVSNQNHNDGKWKSFTLSRIQKQANISIVDIDTNQEENIATSSSGNNFGLD 2461
Query: 144 MQVASDLFVGGIPPDVRLSALTLSTVKYEPPFRGLLANLKLGERPPALLGSQGLRGATAD 203
++ ++ GG+P LS V + + G L ++++ P +L S G T
Sbjct: 2462 LKADDKIYFGGLPTLRNLSMKARPEVNLKK-YSGCLKDIEISRTPYNILSSPDYVGVTKG 2520
Query: 204 PLCAPARNPCANGGLCTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEGKEE 263
C+ + TV P K
Sbjct: 2521 ---------CSLENVYTVSFP------------------------------------KPG 2535
Query: 264 FVATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLML--HTGKSADYVNLSLKSGA 321
FV +LS PI T EI L+F T +G++L G A ++G
Sbjct: 2536 FV-----------ELSPVPIDVGT-EINLSFSTKNESGIILLGSGGTPAPPRRKRRQTGQ 2583
Query: 322 VWLVINLGSGAFEA------------LVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMV 369
+ VI L G E ++ P F+D H V V R +
Sbjct: 2584 AYYVILLNRGRLEVHLSTGARTMRKIVIRPEPNLFHDGREHSVHVERT--------RGIF 2635
Query: 370 TISVDGILTTTGYTQEDYTMLGSDDF--FYIGGSPNTADLPGSPVSN--NFMGCLKDVVY 425
T+ VD Y Q + T+ + ++GG+P + SP+ N F GC+ ++V
Sbjct: 2636 TVQVD---ENRRYMQ-NLTVEQPIEVKKLFVGGAP--PEFQPSPLRNIPPFEGCIWNLVI 2689
Query: 426 KN--NDFKLELS----RLAKEGDPKMKLQGDLSFRCEDVAALDPVTFES----------- 468
+ DF +S + + K++ D + E V +PV +
Sbjct: 2690 NSVPMDFARPVSFKNADIGRCAHQKLREDEDGAAPAEIVIQPEPVPTPAFPTPTPVLTHG 2749
Query: 469 -------PEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGS---HSSAQ 518
P + ++ R I++ F T+ L R +G +
Sbjct: 2750 PCAAESEPALLIGSKQFGLSRNSHIAIAFDDTKVKNRLTIELEVRTEAESGLLFYMARIN 2809
Query: 519 RADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNSRST 578
AD+ ++L +G Y D+GSG + K+NDG+W + R ++G + V+ S
Sbjct: 2810 HADFATVQLRNGLPYFSYDLGSGDTHTMIPT-KINDGQWHKIKIMRSKQEGILYVDGASN 2868
Query: 579 PFLATGDSEILDLESELYLGGLP 601
++ ++ILD+ LY+GGLP
Sbjct: 2869 RTISPKKADILDVVGMLYVGGLP 2891
Score = 76.6 bits (187), Expect = 2e-13
Identities = 99/399 (24%), Positives = 169/399 (42%), Gaps = 58/399 (14%)
Query: 284 QSSTDEITLAFRTLQRNGLMLHTG--KSADYVNLSLKSGAVWLVINLGSGAFEALVEPVN 341
+ S + I + +T + L+ + G K D++ + ++ G V + ++GSG VE +
Sbjct: 2164 KGSYNNIVVNVKTAVADNLLFYLGSAKFIDFLAIEMRKGKVSFLWDVGSGV--GRVEYPD 2221
Query: 342 GKFNDNAWHDVRVTRNLRQHAGIGHAMVTISV---DG----ILTTTGYTQED--YTMLGS 392
+D+ W+ + +R R TISV DG I+ +T ++ YT+L
Sbjct: 2222 LTIDDSYWYRIVASRTGRNG--------TISVRALDGPKASIVPSTHHSTSPPGYTILDV 2273
Query: 393 DD--FFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEGDPKMKLQGD 450
D ++GG + F GC+ + + N L R KEGD K
Sbjct: 2274 DANAMLFVGGLTGKLKKADAVRVITFTGCMGETYFDNKPIGLWNFR-EKEGDCKGCTVSP 2332
Query: 451 LSFRCEDVAALDPVTFESPEAFVALP-RWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGG 509
E D + A V+ P RW ++ FRT + LL++ R
Sbjct: 2333 QVEDSEGTIQFDGEGY----ALVSRPIRWYPN-ISTVMFKFRTFSSSALLMYLATR---- 2383
Query: 510 GAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKG 569
D+ ++EL DGH+ + D+GSG + S++ NDG+W R ++
Sbjct: 2384 --------DLRDFMSVELTDGHIKVSYDLGSGMASV-VSNQNHNDGKWKSFTLSRIQKQA 2434
Query: 570 SISV------NSRSTPFLATGDSEILDLESE--LYLGGLPEGGRVDLPLPPEVWTAALRA 621
+IS+ + ++G++ LDL+++ +Y GGLP + + PEV
Sbjct: 2435 NISIVDIDTNQEENIATSSSGNNFGLDLKADDKIYFGGLPTLRNLSMKARPEVNLKK--- 2491
Query: 622 GYVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETL 660
Y GC++D+ I SR + + VGV CS E +
Sbjct: 2492 -YSGCLKDIEI---SRTPYNILSSPDYVGVTKGCSLENV 2526
Score = 53.9 bits (128), Expect = 1e-06
Identities = 72/317 (22%), Positives = 128/317 (40%), Gaps = 61/317 (19%)
Query: 907 KTTAPDGLLLF-NSGNGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVV 965
KT D LL + S DF+ IE+ KG + +++D+G+G ++ D ++D+ W+ +V
Sbjct: 2175 KTAVADNLLFYLGSAKFIDFLAIEMRKGKVSFLWDVGSGVGRVE-YPDLTIDDSYWYRIV 2233
Query: 966 VSRD--PGNVHTLKIDSRTV-----TQHSNG-----ARNLDLKGELYIGGLSKNMFSNLP 1013
SR G + +D T HS ++D L++GGL+
Sbjct: 2234 ASRTGRNGTISVRALDGPKASIVPSTHHSTSPPGYTILDVDANAMLFVGGLT-------- 2285
Query: 1014 KLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPSTTCTEESCANQGVCLQ 1073
G+L ADA+ I GC G E N+ + L
Sbjct: 2286 -------------------GKLKK--ADAVRVI--TFTGCMG------ETYFDNKPIGLW 2316
Query: 1074 QWDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALIT--YTWPPNDRPSTRMDRLAVGFST 1131
+ DC + V + GT G+G AL++ W PN + + F T
Sbjct: 2317 NFREKEGDCKGCTVSPQVEDSEGTIQFDGEGYALVSRPIRWYPN------ISTVMFKFRT 2370
Query: 1132 HQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFT 1191
SA+L+ + + L D++ + + G + V +++G+ ++ N +DGK+ +
Sbjct: 2371 FSSSALLMYL-ATRDLRDFMSVELTDGHIKVSYDLGSGMASV-VSNQNHNDGKWKSFTLS 2428
Query: 1192 RSGGNATLQVDSWPVNE 1208
R A + + N+
Sbjct: 2429 RIQKQANISIVDIDTNQ 2445
Score = 45.8 bits (107), Expect = 3e-04
Identities = 43/164 (26%), Positives = 68/164 (41%), Gaps = 13/164 (7%)
Query: 53 LSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAE-PATLQLDTP--VAD 109
+ F RT T +LL + D + + ++D +L A P + D
Sbjct: 2964 VEFEFRTTTTTGVLLGISSQ-KMDGMGIEMIDEKLMFHVDNGAGRFTAVYDAGVPGHLCD 3022
Query: 110 DRWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASD-LFVGGIPPDVRLSALTLST 168
+WH V + R L VDG A+ + +D +FVGG P D++ LT S
Sbjct: 3023 GQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTSADTNDPVFVGGFPDDLKQFGLTTSI 3082
Query: 169 VKYEPPFRGLLANLKLGE---RPPALLGSQGLRGATADPLCAPA 209
PFRG + +LKL + +P + ++ L P+ PA
Sbjct: 3083 -----PFRGCIRSLKLTKGTGKPLEVNFAKALELRGVQPVSCPA 3121
Score = 32.3 bits (72), Expect = 3.9
Identities = 18/79 (22%), Positives = 41/79 (51%), Gaps = 1/79 (1%)
Query: 1123 DRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEPNAIVSD 1182
+ + V T +L + SA + D+L + + +G V +++VG+ ++ P+ + D
Sbjct: 2168 NNIVVNVKTAVADNLLFYLGSAKFI-DFLAIEMRKGKVSFLWDVGSGVGRVEYPDLTIDD 2226
Query: 1183 GKYHVVRFTRSGGNATLQV 1201
++ + +R+G N T+ V
Sbjct: 2227 SYWYRIVASRTGRNGTISV 2245
>gi|219842266 usherin isoform B [Homo sapiens]
Length = 5202
Score = 86.7 bits (213), Expect = 2e-16
Identities = 102/420 (24%), Positives = 167/420 (39%), Gaps = 65/420 (15%)
Query: 268 FKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHT---GKSADYVNLSLKSGAVWL 324
F GN + + S +P+ + I +FRT GL++ G +Y L LK G ++
Sbjct: 1522 FIGNGYCKFPSSTHPVNTDFTGIKASFRTKVPEGLIVFAASPGNQEEYFALQLKKGRLYF 1581
Query: 325 VINLGSGAFEALVEPVNGK-FNDNAWHDVRVTRNLRQHAGIGHAMVTISVDGILTTTGYT 383
+ + E +GK ++D WH++ R H G I++DGI T +
Sbjct: 1582 LFDPQGSPVEVTTTNDHGKQYSDGKWHEIIAIR----HQAFGQ----ITLDGIYTGSSAI 1633
Query: 384 QEDYTMLGSDDFFYIGGSPNTADL---PGSPVSNNFMGCLKDVVYKNN----------DF 430
T++G + ++GG P + + + F+GCLKDV + N D+
Sbjct: 1634 LNGSTVIGDNTGVFLGGLPRSYTILRKDPEIIQKGFVGCLKDVHFMKNYNPSAIWEPLDW 1693
Query: 431 KLELSRL----AKEGDPKMKLQGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSI 486
+ ++ + EG P +G F L P F F I
Sbjct: 1694 QSSEEQINVYNSWEGCPASLNEG-AQFLGAGFLELHPYMFHGGMNF------------EI 1740
Query: 487 SLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLD--MGSGGIK 544
S FRT + NGLLLF + D+ AMEL G L L+ + +
Sbjct: 1741 SFKFRTDQLNGLLLFVYNK------------DGPDFLAMELKSGILTFRLNTSLAFTQVD 1788
Query: 545 LRASSRKVNDGEWCHVDFQRDGRKGSISVNSRSTPFLATGDSEILDLESELYLGGLPEGG 604
L N G+W V +++G S SVN +GD ++ + S +Y+GG+P+
Sbjct: 1789 LLLGLSYCN-GKWNKVIIKKEGSFISASVNGLMKHASESGDQPLV-VNSPVYVGGIPQ-- 1844
Query: 605 RVDLPLPPEVWTAALRAGYVGCVRDL-FIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQC 663
L L G+ GC++D+ F G +L ++ V + S ++ C
Sbjct: 1845 ----ELLNSYQHLCLEQGFGGCMKDVKFTRGAVVNLASVSSGAVRVNLDGCLSTDSAVNC 1900
Score = 49.7 bits (117), Expect = 2e-05
Identities = 36/132 (27%), Positives = 67/132 (50%), Gaps = 11/132 (8%)
Query: 906 FKTTAPDGLLLF--NSGNGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSD--KPVNDNQW 961
F+T P+GL++F + GN ++ ++L KG ++++FD P + +D K +D +W
Sbjct: 1548 FRTKVPEGLIVFAASPGNQEEYFALQLKKGRLYFLFDPQGSPVEVTTTNDHGKQYSDGKW 1607
Query: 962 HNVVVSRDP--GNVHTLKIDSRTVTQHSNGARNLDLKGELYIGGL--SKNMFSNLPKLVA 1017
H ++ R G + TL + NG+ + +++GGL S + P+++
Sbjct: 1608 HEIIAIRHQAFGQI-TLDGIYTGSSAILNGSTVIGDNTGVFLGGLPRSYTILRKDPEII- 1665
Query: 1018 SRDGFQGCLASV 1029
+ GF GCL V
Sbjct: 1666 -QKGFVGCLKDV 1676
Score = 49.3 bits (116), Expect = 3e-05
Identities = 79/405 (19%), Positives = 165/405 (40%), Gaps = 46/405 (11%)
Query: 702 LSYDGSMYMKIMLPNAMH---TEAEDVSLRFMSQRAYGLMM-ATTSRESADTLRLELDGG 757
+ + G+ Y K P++ H T+ + F ++ GL++ A + + L+L G
Sbjct: 1520 IRFIGNGYCKF--PSSTHPVNTDFTGIKASFRTKVPEGLIVFAASPGNQEEYFALQLKKG 1577
Query: 758 QMKLTVNLGKGPETLFA----GHKLNDNEWHTVRVVRRGKSLQLSVDNV----------- 802
++ + P + G + +D +WH + +R Q+++D +
Sbjct: 1578 RLYFLFDPQGSPVEVTTTNDHGKQYSDGKWHEIIAIRHQAFGQITLDGIYTGSSAILNGS 1637
Query: 803 TVEGQMAGAHMRLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNG--------QPYMD 854
TV G G + + R+ ++ F+G L + F +P
Sbjct: 1638 TVIGDNTGVFLG----GLPRSYTILRKDPEIIQKGFVGCLKDVHFMKNYNPSAIWEPLDW 1693
Query: 855 QCKDGDITYCELNARFGLRAIVADPVTFKSRSSYLALATLQAYASMH--LFFQFKTTAPD 912
Q + I N+ G A + + F + +L L + M+ + F+F+T +
Sbjct: 1694 QSSEEQINV--YNSWEGCPASLNEGAQFLG-AGFLELHPYMFHGGMNFEISFKFRTDQLN 1750
Query: 913 GLLLF-NSGNGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPG 971
GLLLF + +G DF+ +EL G + + + + + + +W+ V++ ++ G
Sbjct: 1751 GLLLFVYNKDGPDFLAMELKSGILTFRLNTSLAFTQVDLLLGLSYCNGKWNKVIIKKE-G 1809
Query: 972 NVHTLKIDSRTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDL 1031
+ + ++ +G + L + +Y+GG+ + + ++ L + GF GC+ V
Sbjct: 1810 SFISASVNGLMKHASESGDQPLVVNSPVYVGGIPQELLNSYQHLCLEQ-GFGGCMKDVKF 1868
Query: 1032 -NGRLPDLIADALHRIGQVERGCDGPSTTCTEESC-ANQGVCLQQ 1074
G + +L A G V DG +T + +C N + + Q
Sbjct: 1869 TRGAVVNL---ASVSSGAVRVNLDGCLSTDSAVNCRGNDSILVYQ 1910
Score = 47.0 bits (110), Expect = 2e-04
Identities = 32/109 (29%), Positives = 55/109 (50%), Gaps = 2/109 (1%)
Query: 52 ELSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCA-EPATLQLDTPVADD 110
E+SF RT+ LLL++ + DFL + L G L R S A L L +
Sbjct: 1739 EISFKFRTDQLNGLLLFVYNKDGPDFLAMELKSGILTFRLNTSLAFTQVDLLLGLSYCNG 1798
Query: 111 RWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDV 159
+W+ V++ ++ + +V+G + A S + + V S ++VGGIP ++
Sbjct: 1799 KWNKVIIKKEGSFISASVNGLMKHAS-ESGDQPLVVNSPVYVGGIPQEL 1846
>gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo
sapiens]
Length = 2923
Score = 82.4 bits (202), Expect = 3e-15
Identities = 79/323 (24%), Positives = 126/323 (39%), Gaps = 60/323 (18%)
Query: 856 CKDGDIT--YCELNARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDG 913
C GD YC++ R +F + S ++ L+ L F T DG
Sbjct: 1355 CPSGDFEKPYCQVTTR-----------SFPAHS-FITFRGLRQRFHFTLALSFATKERDG 1402
Query: 914 LLLFNS--GNGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRD-- 969
LLL+N +DF+ +E+++ + F G + + V+D QWH V +
Sbjct: 1403 LLLYNGRFNEKHDFVALEVIQEQVQLTFSAGESTTTVSPFVPGGVSDGQWHTVQLKYYNK 1462
Query: 970 --------PGNVHTLKIDSRTVTQHSNGA-----------------------RNLDLKGE 998
P K+ TV G ++LDL G
Sbjct: 1463 PLLGQTGLPQGPSEQKVAVVTVDGCDTGVALRFGSVLGNYSCAAQGTQGGSKKSLDLTGP 1522
Query: 999 LYIGGLSKNMFSNLPKLVASR-DGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPS 1057
L +GG+ +LP+ R F GC+ ++ ++ R D+ AD + G V GC
Sbjct: 1523 LLLGGVP-----DLPESFPVRMRQFVGCMRNLQVDSRHIDM-ADFIANNGTVP-GCPAKK 1575
Query: 1058 TTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALITYTWPPNDR 1117
C +C N G C+ QWD F+C+C + +GG C G +L+ W
Sbjct: 1576 NVCDSNTCHNGGTCVNQWDAFSCECPL-GFGGKSCAQEMANPQHFLGSSLV--AWHGLSL 1632
Query: 1118 PSTRMDRLAVGFSTHQRSAVLVR 1140
P ++ L++ F T Q VL++
Sbjct: 1633 PISQPWYLSLMFRTRQADGVLLQ 1655
Score = 76.3 bits (186), Expect = 2e-13
Identities = 88/338 (26%), Positives = 142/338 (42%), Gaps = 65/338 (19%)
Query: 485 SISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIK 544
+++L F T E +GLLL++ GR ++ D+ A+E++ + L G
Sbjct: 1390 TLALSFATKERDGLLLYN-GR----------FNEKHDFVALEVIQEQVQLTFSAGESTTT 1438
Query: 545 LRAS-SRKVNDGEWCHVDFQR-------------------------DG-------RKGSI 571
+ V+DG+W V + DG R GS+
Sbjct: 1439 VSPFVPGGVSDGQWHTVQLKYYNKPLLGQTGLPQGPSEQKVAVVTVDGCDTGVALRFGSV 1498
Query: 572 SVN-SRSTPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDL 630
N S + G + LDL L LGG+P+ PE + +R +VGC+R+L
Sbjct: 1499 LGNYSCAAQGTQGGSKKSLDLTGPLLLGGVPD--------LPESFPVRMRQ-FVGCMRNL 1549
Query: 631 FIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCREGWNRFICDCIGTGF 690
+D R D+ G V P C + C S C NGG C W+ F C+C GF
Sbjct: 1550 QVDSRHIDMADFIANNGTV---PGCPAKK-NVCDSNTCHNGGTCVNQWDAFSCEC-PLGF 1604
Query: 691 LGRVCERE-ATVLSYDGSMYMKIMLPNAMHTEAEDVSLRFMSQRAYGLMMATTSRESADT 749
G+ C +E A + GS + + ++ +SL F +++A G+++ +R T
Sbjct: 1605 GGKSCAQEMANPQHFLGSSLVAWHGLSLPISQPWYLSLMFRTRQADGVLLQAITR-GRST 1663
Query: 750 LRLELDGGQMKLTVNLGKGPET---LFAGHKLNDNEWH 784
+ L+L G + L+V G G + + ND +WH
Sbjct: 1664 ITLQLREGHVMLSVE-GTGLQASSLRLEPGRANDGDWH 1700
Score = 71.2 bits (173), Expect = 8e-12
Identities = 126/557 (22%), Positives = 198/557 (35%), Gaps = 127/557 (22%)
Query: 206 CAPARNPCANGGLCTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEGKEEFV 265
C P C NGG C L G CDC F +C PAH +
Sbjct: 1332 CTPG--VCKNGGTCVNLLVGGFKCDCPSGDFEKPYCQVTTRSF--PAHSFI--------- 1378
Query: 266 ATFKG-NEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHTGK---SADYVNLSLKSGA 321
TF+G + F + L+ L+F T +R+GL+L+ G+ D+V L +
Sbjct: 1379 -TFRGLRQRFHFTLA------------LSFATKERDGLLLYNGRFNEKHDFVALEVIQEQ 1425
Query: 322 VWLVINLGSGAFEALVEP-VNGKFNDNAWHDVRV---TRNLRQHAGIGHA-----MVTIS 372
V L + G V P V G +D WH V++ + L G+ + ++
Sbjct: 1426 VQLTFSAGEST--TTVSPFVPGGVSDGQWHTVQLKYYNKPLLGQTGLPQGPSEQKVAVVT 1483
Query: 373 VDGILT-------------------TTGYTQEDYTMLGSDDFFYIGGSPNTADLPGS-PV 412
VDG T T G +++ + G +GG P DLP S PV
Sbjct: 1484 VDGCDTGVALRFGSVLGNYSCAAQGTQGGSKKSLDLTGP---LLLGGVP---DLPESFPV 1537
Query: 413 -SNNFMGCLKDVVYKNNDFKLE---LSRLAKEGDPKMKLQGDLSFRCED----VAALDPV 464
F+GC++++ + + + G P K D S C + V D
Sbjct: 1538 RMRQFVGCMRNLQVDSRHIDMADFIANNGTVPGCPAKKNVCD-SNTCHNGGTCVNQWDAF 1596
Query: 465 TFESPEAF-----------------VALPRWSA-----KRTGSISLDFRTTEPNGLLL-- 500
+ E P F +L W + +SL FRT + +G+LL
Sbjct: 1597 SCECPLGFGGKSCAQEMANPQHFLGSSLVAWHGLSLPISQPWYLSLMFRTRQADGVLLQA 1656
Query: 501 FSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLD-MGSGGIKLRASSRKVNDGEWCH 559
++GR ++L +GH+ L ++ G LR + NDG+W H
Sbjct: 1657 ITRGRST---------------ITLQLREGHVMLSVEGTGLQASSLRLEPGRANDGDWHH 1701
Query: 560 VDFQRDGRKGSISVNSRSTPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAAL 619
G + + L+L + GG +P P +
Sbjct: 1702 AQLALGASGGPGHAILSFDYGQQRAEGNLGPRLHGLHLSNITVGG---IPGP----AGGV 1754
Query: 620 RAGYVGCVRDLFIDGRSRDLRGLAEAQG-AVGVAPFCSRETLKQCASAPCRNGGVCREGW 678
G+ GC++ + + + L + G ++ V CS C S PC C W
Sbjct: 1755 ARGFRGCLQGVRVSDTPEGVNSLDPSHGESINVEQGCSLP--DPCDSNPCPANSYCSNDW 1812
Query: 679 NRFICDCIGTGFLGRVC 695
+ + C C G+ G C
Sbjct: 1813 DSYSCSC-DPGYYGDNC 1828
Score = 61.6 bits (148), Expect = 6e-09
Identities = 99/414 (23%), Positives = 155/414 (37%), Gaps = 82/414 (19%)
Query: 53 LSFSLRTNATRALLLYLDDGGDC-DFLELLLVDGRLRLRFTLSCAEPATLQLDTP--VAD 109
L+ S T LLLY + DF+ L ++ +++L F+ T+ P V+D
Sbjct: 1391 LALSFATKERDGLLLYNGRFNEKHDFVALEVIQEQVQLTFSAG-ESTTTVSPFVPGGVSD 1449
Query: 110 DRWHMVLLT----------------RDARRTALAVDGEARAAEVR--------------- 138
+WH V L + + + VDG +R
Sbjct: 1450 GQWHTVQLKYYNKPLLGQTGLPQGPSEQKVAVVTVDGCDTGVALRFGSVLGNYSCAAQGT 1509
Query: 139 --SKRREMQVASDLFVGGIPPDVRLSALTLSTVKYEPPFRGLLANLKLGERPPALLGSQG 196
++ + + L +GG+P L S F G + NL++ R +
Sbjct: 1510 QGGSKKSLDLTGPLLLGGVPD------LPESFPVRMRQFVGCMRNLQVDSRHIDMADFIA 1563
Query: 197 LRGATADPLCAPAR------NPCANGGLCTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEG 250
G P C PA+ N C NGG C V C+C GFGGK C++E M
Sbjct: 1564 NNGTV--PGC-PAKKNVCDSNTCHNGGTC-VNQWDAFSCECP-LGFGGKSCAQE---MAN 1615
Query: 251 PAHLTLNSEGKEEFVATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHT-GKS 309
P H F G+ + PI S ++L FRT Q +G++L +
Sbjct: 1616 PQH--------------FLGSSLVAWHGLSLPI-SQPWYLSLMFRTRQADGVLLQAITRG 1660
Query: 310 ADYVNLSLKSGAVWLVINLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMV 369
+ L L+ G V L + G+G + + G+ ND WH ++ L G GHA++
Sbjct: 1661 RSTITLQLREGHVMLSVE-GTGLQASSLRLEPGRANDGDWHHAQLA--LGASGGPGHAIL 1717
Query: 370 TISVDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDV 423
+ + + S+ +GG P P V+ F GCL+ V
Sbjct: 1718 SFDYGQQRAEGNLGPRLHGLHLSN--ITVGGIPG----PAGGVARGFRGCLQGV 1765
Score = 49.3 bits (116), Expect = 3e-05
Identities = 66/247 (26%), Positives = 99/247 (40%), Gaps = 23/247 (9%)
Query: 860 DITYCELNARFGLRAI---VADPVTFKSRSSYLALATLQAYASM--HLFFQFKTTAPDGL 914
D CE FG ++ +A+P F SS +A L S +L F+T DG+
Sbjct: 1594 DAFSCECPLGFGGKSCAQEMANPQHFLG-SSLVAWHGLSLPISQPWYLSLMFRTRQADGV 1652
Query: 915 LLFNSGNGNDFIVIELVKGYIHY-VFDLGNGPSLMKGNSDKPVNDNQWHNVVV----SRD 969
LL G I ++L +G++ V G S ++ + ND WH+ + S
Sbjct: 1653 LLQAITRGRSTITLQLREGHVMLSVEGTGLQASSLRLEPGR-ANDGDWHHAQLALGASGG 1711
Query: 970 PGNVHTLKIDSRTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASV 1029
PG+ L D Q + G L G L++ ++ VA GF+GCL V
Sbjct: 1712 PGHA-ILSFDYGQ--QRAEGNLGPRLHG-LHLSNITVGGIPGPAGGVAR--GFRGCLQGV 1765
Query: 1030 DLNGRLPDLIADALHRIGQ---VERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTS 1086
++ P+ + G+ VE+GC P C C C WD ++C C
Sbjct: 1766 RVSDT-PEGVNSLDPSHGESINVEQGCSLPDP-CDSNPCPANSYCSNDWDSYSCSCDPGY 1823
Query: 1087 YGGPVCN 1093
YG N
Sbjct: 1824 YGDNCTN 1830
Score = 44.7 bits (104), Expect = 8e-04
Identities = 40/136 (29%), Positives = 59/136 (43%), Gaps = 11/136 (8%)
Query: 1057 STTCTEESCANQGVCLQQW-DGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALITYTWPPN 1115
S CT C N G C+ GF CDC + P C TT F + IT+
Sbjct: 1329 SGRCTPGVCKNGGTCVNLLVGGFKCDCPSGDFEKPYCQ--VTTRSF-PAHSFITFRGLRQ 1385
Query: 1116 DRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDE 1175
T LA+ F+T +R +L+ + D++ L + Q V + F+ G T+
Sbjct: 1386 RFHFT----LALSFATKERDGLLLYNGRFNEKHDFVALEVIQEQVQLTFSAGESTTTVSP 1441
Query: 1176 --PNAIVSDGKYHVVR 1189
P VSDG++H V+
Sbjct: 1442 FVPGG-VSDGQWHTVQ 1456
Score = 43.5 bits (101), Expect = 0.002
Identities = 44/169 (26%), Positives = 71/169 (42%), Gaps = 21/169 (12%)
Query: 662 QCASAPCRNGGVCREGW-NRFICDCIGTGFLGRVCEREATVLSYDGSMYMKIM-LPNAMH 719
+C C+NGG C F CDC F C + T S+ ++ L H
Sbjct: 1331 RCTPGVCKNGGTCVNLLVGGFKCDCPSGDFEKPYC--QVTTRSFPAHSFITFRGLRQRFH 1388
Query: 720 TEAEDVSLRFMSQRAYGLMMAT-TSRESADTLRLELDGGQMKLTVNLGKGPETL--FAGH 776
++L F ++ GL++ E D + LE+ Q++LT + G+ T+ F
Sbjct: 1389 F---TLALSFATKERDGLLLYNGRFNEKHDFVALEVIQEQVQLTFSAGESTTTVSPFVPG 1445
Query: 777 KLNDNEWHTVRVVRRGKSL-----------QLSVDNVTVEGQMAGAHMR 814
++D +WHTV++ K L + V VTV+G G +R
Sbjct: 1446 GVSDGQWHTVQLKYYNKPLLGQTGLPQGPSEQKVAVVTVDGCDTGVALR 1494
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 70,894,270
Number of Sequences: 37866
Number of extensions: 3865400
Number of successful extensions: 22759
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 143
Number of HSP's successfully gapped in prelim test: 686
Number of HSP's that attempted gapping in prelim test: 14367
Number of HSP's gapped (non-prelim): 6428
length of query: 1642
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1526
effective length of database: 13,855,062
effective search space: 21142824612
effective search space used: 21142824612
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.