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Search of human proteins with 21070969
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21070969 neurexin 3 isoform 1 precursor [Homo sapiens]
(1061 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21070969 neurexin 3 isoform 1 precursor [Homo sapiens] 2153 0.0
gi|14149613 neurexin 1 isoform alpha1 precursor [Homo sapiens] 1691 0.0
gi|208609951 neurexin 1 isoform alpha2 precursor [Homo sapiens] 1675 0.0
gi|14211536 neurexin 2 isoform alpha-1 precursor [Homo sapiens] 1443 0.0
gi|21166380 neurexin 2 isoform alpha-2 precursor [Homo sapiens] 1437 0.0
gi|41350305 neurexin 3 isoform 2 precursor [Homo sapiens] 684 0.0
gi|157427673 neurexin 3 isoform 3 precursor [Homo sapiens] 674 0.0
gi|21070967 neurexin 1 isoform beta precursor [Homo sapiens] 482 e-136
gi|21166382 neurexin 2 isoform beta precursor [Homo sapiens] 328 1e-89
gi|7662350 cell recognition molecule Caspr2 precursor [Homo sapi... 154 6e-37
gi|116284404 cell recognition protein CASPR4 isoform 1 [Homo sap... 125 2e-28
gi|148664242 cell recognition protein CASPR4 isoform 2 [Homo sap... 119 1e-26
gi|18640734 contactin associated protein-like 5 [Homo sapiens] 117 6e-26
gi|239743756 PREDICTED: hypothetical protein LOC389722 isoform 2... 117 8e-26
gi|239743754 PREDICTED: hypothetical protein LOC389722 isoform 1... 117 8e-26
gi|4505463 contactin associated protein 1 precursor [Homo sapiens] 115 2e-25
gi|33469931 EGF-like, fibronectin type III and laminin G domains... 113 1e-24
gi|33469929 EGF-like, fibronectin type III and laminin G domains... 113 1e-24
gi|47519929 cell recognition molecule CASPR3 [Homo sapiens] 112 2e-24
gi|239743797 PREDICTED: similar to cell recognition molecule CAS... 110 5e-24
gi|38788416 laminin, alpha 1 precursor [Homo sapiens] 108 3e-23
gi|54873613 agrin [Homo sapiens] 103 9e-22
gi|33469935 EGF-like, fibronectin type III and laminin G domains... 100 9e-21
gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo... 92 3e-18
gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo ... 89 2e-17
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 88 5e-17
gi|119466532 laminin alpha 2 subunit isoform b precursor [Homo s... 88 5e-17
gi|28559088 laminin alpha 2 subunit isoform a precursor [Homo sa... 87 1e-16
gi|41327708 crumbs homolog 1 precursor [Homo sapiens] 86 2e-16
gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo s... 85 4e-16
>gi|21070969 neurexin 3 isoform 1 precursor [Homo sapiens]
Length = 1061
Score = 2153 bits (5578), Expect = 0.0
Identities = 1061/1061 (100%), Positives = 1061/1061 (100%)
Query: 1 MLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDIRLELSRLARIADTKMKIY 60
MLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDIRLELSRLARIADTKMKIY
Sbjct: 1 MLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDIRLELSRLARIADTKMKIY 60
Query: 61 GEVVFKCENVATLDPINFETPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQE 120
GEVVFKCENVATLDPINFETPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQE
Sbjct: 61 GEVVFKCENVATLDPINFETPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQE 120
Query: 121 RKDARSQKNTKVDFFAVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQRDGRS 180
RKDARSQKNTKVDFFAVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQRDGRS
Sbjct: 121 RKDARSQKNTKVDFFAVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQRDGRS 180
Query: 181 GTISVNSRRTPFTASGESEILDLEGDMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRD 240
GTISVNSRRTPFTASGESEILDLEGDMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRD
Sbjct: 181 GTISVNSRRTPFTASGESEILDLEGDMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRD 240
Query: 241 LFIDGRSKNIRQLAEMQNAAGVKSSCSRMSAKQCDSYPCKNNAVCKDGWNRFICDCTGTG 300
LFIDGRSKNIRQLAEMQNAAGVKSSCSRMSAKQCDSYPCKNNAVCKDGWNRFICDCTGTG
Sbjct: 241 LFIDGRSKNIRQLAEMQNAAGVKSSCSRMSAKQCDSYPCKNNAVCKDGWNRFICDCTGTG 300
Query: 301 YWGRTCEREASILSYDGSMYMKIIMPMVMHTEAEDVSFRFMSQRAYGLLVATTSRDSADT 360
YWGRTCEREASILSYDGSMYMKIIMPMVMHTEAEDVSFRFMSQRAYGLLVATTSRDSADT
Sbjct: 301 YWGRTCEREASILSYDGSMYMKIIMPMVMHTEAEDVSFRFMSQRAYGLLVATTSRDSADT 360
Query: 361 LRLELDGGRVKLMVNLDCIRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTVD 420
LRLELDGGRVKLMVNLDCIRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTVD
Sbjct: 361 LRLELDGGRVKLMVNLDCIRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTVD 420
Query: 421 DDVAEGTMVGDHTRLEFHNIETGIMTEKRYISVVPSSFIGHLQSLMFNGLLYIDLCKNGD 480
DDVAEGTMVGDHTRLEFHNIETGIMTEKRYISVVPSSFIGHLQSLMFNGLLYIDLCKNGD
Sbjct: 421 DDVAEGTMVGDHTRLEFHNIETGIMTEKRYISVVPSSFIGHLQSLMFNGLLYIDLCKNGD 480
Query: 481 IDYCELKARFGLRNIIADPVTFKTKSSYLSLATLQAYTSMHLFFQFKTTSPDGFILFNSG 540
IDYCELKARFGLRNIIADPVTFKTKSSYLSLATLQAYTSMHLFFQFKTTSPDGFILFNSG
Sbjct: 481 IDYCELKARFGLRNIIADPVTFKTKSSYLSLATLQAYTSMHLFFQFKTTSPDGFILFNSG 540
Query: 541 DGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSDRPLNDNQWHNVVITRDNSNTHSLKVDT 600
DGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSDRPLNDNQWHNVVITRDNSNTHSLKVDT
Sbjct: 541 DGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSDRPLNDNQWHNVVITRDNSNTHSLKVDT 600
Query: 601 KVVTQVINGAKNLDLKGDLYMAGLAQGMYSNLPKLVASRDGFQGCLASVDLNGRLPDLIN 660
KVVTQVINGAKNLDLKGDLYMAGLAQGMYSNLPKLVASRDGFQGCLASVDLNGRLPDLIN
Sbjct: 601 KVVTQVINGAKNLDLKGDLYMAGLAQGMYSNLPKLVASRDGFQGCLASVDLNGRLPDLIN 660
Query: 661 DALHRSGQIERGCEGPSTTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQCNDPGATYI 720
DALHRSGQIERGCEGPSTTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQCNDPGATYI
Sbjct: 661 DALHRSGQIERGCEGPSTTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQCNDPGATYI 720
Query: 721 FGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKI 780
FGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKI
Sbjct: 721 FGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKI 780
Query: 781 GVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGRQLTIFN 840
GVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGRQLTIFN
Sbjct: 781 GVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGRQLTIFN 840
Query: 841 TQAQIAIGGKDKGRLFQGQLSGLYYDGLKVLNMAAENNPNIKINGSVRLVGEVPSILGTT 900
TQAQIAIGGKDKGRLFQGQLSGLYYDGLKVLNMAAENNPNIKINGSVRLVGEVPSILGTT
Sbjct: 841 TQAQIAIGGKDKGRLFQGQLSGLYYDGLKVLNMAAENNPNIKINGSVRLVGEVPSILGTT 900
Query: 901 QTTSMPPEMSTTVMETTTTMATTTTRKNRSTASIQPTSDDLVSSAECSSDDEDFVECEPS 960
QTTSMPPEMSTTVMETTTTMATTTTRKNRSTASIQPTSDDLVSSAECSSDDEDFVECEPS
Sbjct: 901 QTTSMPPEMSTTVMETTTTMATTTTRKNRSTASIQPTSDDLVSSAECSSDDEDFVECEPS 960
Query: 961 TANPTEPGIRRVPGASEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQV 1020
TANPTEPGIRRVPGASEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQV
Sbjct: 961 TANPTEPGIRRVPGASEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQV 1020
Query: 1021 DETRNYISNSAQSNGTLMKEKQQSSKSGHKKQKNKDREYYV 1061
DETRNYISNSAQSNGTLMKEKQQSSKSGHKKQKNKDREYYV
Sbjct: 1021 DETRNYISNSAQSNGTLMKEKQQSSKSGHKKQKNKDREYYV 1061
>gi|14149613 neurexin 1 isoform alpha1 precursor [Homo sapiens]
Length = 1477
Score = 1691 bits (4379), Expect = 0.0
Identities = 820/1071 (76%), Positives = 939/1071 (87%), Gaps = 10/1071 (0%)
Query: 1 MLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDIRLELSRLARIADTKMKIY 60
MLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNND+RLELSRLA+ D KMKI+
Sbjct: 407 MLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIH 466
Query: 61 GEVVFKCENVATLDPINFETPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQE 120
G V FKCENVATLDPI FETPE++ISLPKWN K+ GSISFDFRTTEPNGLILF+HGKP+
Sbjct: 467 GVVAFKCENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRH 526
Query: 121 RKDARSQKNTKVDFFAVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQRDGRS 180
+KDA+ + KVDFFA+E+LDG+LYLLLDMGSGTIK+KA KK NDGEWYHVD QRDGRS
Sbjct: 527 QKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRS 586
Query: 181 GTISVNSRRTPFTASGESEILDLEGDMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRD 240
GTISVN+ RTP+TA GESEILDL+ ++YLGGLPEN+AGL+ PTE+WTA+LNYGYVGCIRD
Sbjct: 587 GTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRD 646
Query: 241 LFIDGRSKNIRQLAEMQNAAGVKSSCSRMSAKQCDSYPCKNNAVCKDGWNRFICDCTGTG 300
LFIDG+SK+IRQ+AE+Q+ AGVK SCS+ +AK C S PCKNN +C+DGWNR++CDC+GTG
Sbjct: 647 LFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTG 706
Query: 301 YWGRTCEREASILSYDGSMYMKIIMPMVMHTEAEDVSFRFMSQRAYGLLVATTSRDSADT 360
Y GR+CEREA++LSYDGSM+MKI +P+VMHTEAEDVS RF SQRAYG+L+ATTSRDSADT
Sbjct: 707 YLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADT 766
Query: 361 LRLELDGGRVKLMVNLDCIRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTVD 420
LRLELD GRVKL VNLDCIRINCNSSKGPETL+AG LNDNEWHTVRVVRRGKSLKLTVD
Sbjct: 767 LRLELDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVD 826
Query: 421 DDVA-EGTMVGDHTRLEFHNIETGIMTEKRYISVVPSSFIGHLQSLMFNGLLYIDLCKNG 479
D A G M GDHTRLEFHNIETGI+TE+RY+S VPS+FIGHLQSL FNG+ YIDLCKNG
Sbjct: 827 DQQAMTGQMAGDHTRLEFHNIETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNG 886
Query: 480 DIDYCELKARFGLRNIIADPVTFKTKSSYLSLATLQAYTSMHLFFQFKTTSPDGFILFNS 539
DIDYCEL ARFG RNIIADPVTFKTKSSY++LATLQAYTSMHLFFQFKTTS DG IL+NS
Sbjct: 887 DIDYCELNARFGFRNIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNS 946
Query: 540 GDGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSDRPLNDNQWHNVVITRDNSNTHSLKVD 599
GDGNDFI VELVKGY+HYVFDLGNG N+IKG+S++PLNDNQWHNV+I+RD SN H++K+D
Sbjct: 947 GDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKID 1006
Query: 600 TKVVTQVINGAKNLDLKGDLYMAGLAQGMYSNLPKLVASRDGFQGCLASVDLNGRLPDLI 659
TK+ TQ+ GA+NLDLK DLY+ G+A+ Y +LPKLV +++GFQGCLASVDLNGRLPDLI
Sbjct: 1007 TKITTQITAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLI 1066
Query: 660 NDALHRSGQIERGCEGPSTTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQCNDPGATY 719
+DAL +GQIERGCEGPSTTCQEDSC+NQGVC+QQW+GF+CDCSMTS+SG CNDPG TY
Sbjct: 1067 SDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTY 1126
Query: 720 IFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGK 779
IF K GG I Y WP NDRPSTR+DRLA+GFST K+ +LVR+DS+ GLGD+L+LHI QGK
Sbjct: 1127 IFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGK 1186
Query: 780 IGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGRQLTIF 839
IGV FN+GT DI+I+E +NDGKYHVVRFTR+GGNATLQVD+WPV E YP GRQLTIF
Sbjct: 1187 IGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGRQLTIF 1246
Query: 840 NTQAQIAIGGKDKGRLFQGQLSGLYYDGLKVLNMAAENNPNIKINGSVRLVGEVPSILGT 899
N+QA I IGGK++G+ FQGQLSGLYY+GLKVLNMAAEN+ NI I G+VRLVGEVPS + T
Sbjct: 1247 NSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTT 1306
Query: 900 TQT-TSMPPEMSTTVMETTTTMATTTTRKNRSTAS---IQPTSDDLVSSAECSSDDEDFV 955
T T+M EMST++METTTT+AT+T R+ + Q T D LV+SAEC SDDED
Sbjct: 1307 ESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDDILVASAECPSDDEDID 1366
Query: 956 ECEPST---ANPTEPGIRR-VPGASEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYR 1011
CEPS+ ANPT G R PG++EVIRESSSTTGMVVGIVAAAALCILILLYAMYKYR
Sbjct: 1367 PCEPSSGGLANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYR 1426
Query: 1012 NRDEGSYQVDETRNYISNSAQSNGTLMKEKQQSS-KSGHKKQKNKDREYYV 1061
NRDEGSY VDE+RNYISNSAQSNG ++KEKQ SS KS +K +KNKD+EYYV
Sbjct: 1427 NRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV 1477
Score = 195 bits (496), Expect = 2e-49
Identities = 195/815 (23%), Positives = 342/815 (41%), Gaps = 110/815 (13%)
Query: 88 PKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFAVELL-DGNLYL 146
PKWN +SF +T GL+L+ + DF + L G L L
Sbjct: 44 PKWNACCESEMSFQLKTRSARGLVLYFDDEGF------------CDFLELILTRGGRLQL 91
Query: 147 LLDMGSGTIKVKATQKKANDGEWYHVDIQRDGRSGTISVNSRRTPFT-ASGESEILDLEG 205
+ NDG W+ V I+R R+ T+ ++ + + + +
Sbjct: 92 SFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFS 151
Query: 206 DMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGR------SKNIRQLAEMQNA 259
+++GGLP L L + + G IRD+ ++ S ++ E N+
Sbjct: 152 GLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEPPNS 211
Query: 260 AGVKSSCSRMSAKQCDSYPCKNNAVCKDGWNRFICDCTGTGYWGRTCEREAS-------- 311
G S C + ++ + C N VC ++ +CDC+ TG+ G+ C +E +
Sbjct: 212 GG-GSPCE--AGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEGLAHL 268
Query: 312 --------------ILSYDGSMYMKI-IMPMVMHTEAEDVSFRFMSQRAYGLLVATTSRD 356
I ++ GS Y + + + +++++ F + + GL++ T
Sbjct: 269 MMGDQGKSKGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGK-- 326
Query: 357 SADTLRLELDGGRVKLMVNLDCIRINCNSSKGPETLY--AGQKLNDNEWHTVRVVRRGKS 414
SAD + L L G V L++NL S E L K NDN WH V+V R +
Sbjct: 327 SADYVNLALKNGAVSLVINL--------GSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQ 378
Query: 415 ------LKLTVDDD---VAEGTMVGDHTRL---EFHNIETGIMTEKRYISVVPSSFIGHL 462
+T+ D G D+T L +F + T S V ++F+G L
Sbjct: 379 HSGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCL 438
Query: 463 QSLMFNG----LLYIDLCKNGDIDY-CELKARFGLRNIIA-DPVTFKTKSSYLSLATLQA 516
+ +++ L L K GD F N+ DP+TF+T S++SL A
Sbjct: 439 KEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPESFISLPKWNA 498
Query: 517 YTSMHLFFQFKTTSPDGFILFNSGDGN-------------DFIAVELVKGYIHYVFDLGN 563
+ + F F+TT P+G ILF+ G DF A+E++ G+++ + D+G+
Sbjct: 499 KKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGS 558
Query: 564 GPNVIKGNSDRPLNDNQWHNVVITRDNSNTHSLKVDTKVVTQVING-AKNLDLKGDLYMA 622
G IK + +ND +W++V RD + ++ V+T G ++ LDL +LY+
Sbjct: 559 GTIKIKALL-KKVNDGEWYHVDFQRD-GRSGTISVNTLRTPYTAPGESEILDLDDELYLG 616
Query: 623 GLAQG----MYSNLPKLVASRDGFQGCLASVDLNGRLPDLINDA-LHRSGQIERGC-EGP 676
GL + ++ G+ GC+ + ++G+ D+ A + + ++ C +
Sbjct: 617 GLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKET 676
Query: 677 STTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQCNDPGATYIFGKSGGLILYTWPAND 736
+ C + C N G+C W + CDCS T Y G C + AT + + P
Sbjct: 677 AKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSC-EREATVLSYDGSMFMKIQLPV-- 733
Query: 737 RPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEE 796
T ++ +++ F + GIL+ S D L+L ++ G++ + N+ + I+
Sbjct: 734 VMHTEAEDVSLRFRSQRAYGILMATTSRDS-ADTLRLELDAGRVKLTVNLDCIRINCNSS 792
Query: 797 RTP--------VNDGKYHVVRFTRNGGNATLQVDN 823
+ P +ND ++H VR R G + L VD+
Sbjct: 793 KGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDD 827
Score = 38.9 bits (89), Expect = 0.026
Identities = 28/88 (31%), Positives = 45/88 (51%), Gaps = 4/88 (4%)
Query: 756 GILVRIDSAPGLGDFLQLHIEQG-KIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNG 814
G+++ D G DFL+L + +G ++ + F+I + + TPVNDG +H VR R
Sbjct: 65 GLVLYFDDE-GFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQF 123
Query: 815 GNATLQVDNWPVN--EHYPTGRQLTIFN 840
N TL +D E R +T+F+
Sbjct: 124 RNTTLFIDQVEAKWVEVKSKRRDMTVFS 151
>gi|208609951 neurexin 1 isoform alpha2 precursor [Homo sapiens]
Length = 1547
Score = 1675 bits (4338), Expect = 0.0
Identities = 820/1101 (74%), Positives = 939/1101 (85%), Gaps = 40/1101 (3%)
Query: 1 MLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDIRLELSRLARIADTKMKIY 60
MLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNND+RLELSRLA+ D KMKI+
Sbjct: 447 MLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIH 506
Query: 61 GEVVFKCENVATLDPINFETPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQE 120
G V FKCENVATLDPI FETPE++ISLPKWN K+ GSISFDFRTTEPNGLILF+HGKP+
Sbjct: 507 GVVAFKCENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRH 566
Query: 121 RKDARSQKNTKVDFFAVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQRDGRS 180
+KDA+ + KVDFFA+E+LDG+LYLLLDMGSGTIK+KA KK NDGEWYHVD QRDGRS
Sbjct: 567 QKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRS 626
Query: 181 GTISVNSRRTPFTASGESEILDLEGDMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRD 240
GTISVN+ RTP+TA GESEILDL+ ++YLGGLPEN+AGL+ PTE+WTA+LNYGYVGCIRD
Sbjct: 627 GTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRD 686
Query: 241 LFIDGRSKNIRQLAEMQNAAGVKSSCSRMSAKQCDSYPCKNNAVCKDGWNRFICDCTGTG 300
LFIDG+SK+IRQ+AE+Q+ AGVK SCS+ +AK C S PCKNN +C+DGWNR++CDC+GTG
Sbjct: 687 LFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTG 746
Query: 301 YWGRTCEREASILSYDGSMYMKIIMPMVMHTEAEDVSFRFMSQRAYGLLVATTSRDSADT 360
Y GR+CEREA++LSYDGSM+MKI +P+VMHTEAEDVS RF SQRAYG+L+ATTSRDSADT
Sbjct: 747 YLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADT 806
Query: 361 LRLELDGGRVKLMVNLDCIRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTVD 420
LRLELD GRVKL VNLDCIRINCNSSKGPETL+AG LNDNEWHTVRVVRRGKSLKLTVD
Sbjct: 807 LRLELDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVD 866
Query: 421 DDVA-EGTMVGDHTRLEFHNIETGIMTEKRYISVVPSSFIGHLQSLMFNGLLYIDLCKNG 479
D A G M GDHTRLEFHNIETGI+TE+RY+S VPS+FIGHLQSL FNG+ YIDLCKNG
Sbjct: 867 DQQAMTGQMAGDHTRLEFHNIETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNG 926
Query: 480 DIDYCELKARFGLRNIIADPVTFKTKSSYLSLATLQAYTSMHLFFQFKTTSPDGFILFNS 539
DIDYCEL ARFG RNIIADPVTFKTKSSY++LATLQAYTSMHLFFQFKTTS DG IL+NS
Sbjct: 927 DIDYCELNARFGFRNIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNS 986
Query: 540 GDGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSDRPLNDNQWHNVVITRDNSNTHSLKVD 599
GDGNDFI VELVKGY+HYVFDLGNG N+IKG+S++PLNDNQWHNV+I+RD SN H++K+D
Sbjct: 987 GDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKID 1046
Query: 600 TKVVTQVINGAKNLDLKGDLYMAGLAQGMYSNLPKLVASRDGFQGCLASVDLNGRLPDLI 659
TK+ TQ+ GA+NLDLK DLY+ G+A+ Y +LPKLV +++GFQGCLASVDLNGRLPDLI
Sbjct: 1047 TKITTQITAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLI 1106
Query: 660 NDALHRSGQIERGCEGPSTTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQCNDPGATY 719
+DAL +GQIERGCEGPSTTCQEDSC+NQGVC+QQW+GF+CDCSMTS+SG CNDPG TY
Sbjct: 1107 SDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTY 1166
Query: 720 IFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGK 779
IF K GG I Y WP NDRPSTR+DRLA+GFST K+ +LVR+DS+ GLGD+L+LHI QGK
Sbjct: 1167 IFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGK 1226
Query: 780 IGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPT------- 832
IGV FN+GT DI+I+E +NDGKYHVVRFTR+GGNATLQVD+WPV E YP
Sbjct: 1227 IGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNER 1286
Query: 833 -----------------------GRQLTIFNTQAQIAIGGKDKGRLFQGQLSGLYYDGLK 869
GRQLTIFN+QA I IGGK++G+ FQGQLSGLYY+GLK
Sbjct: 1287 LAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQATIIIGGKEQGQPFQGQLSGLYYNGLK 1346
Query: 870 VLNMAAENNPNIKINGSVRLVGEVPSILGTTQT-TSMPPEMSTTVMETTTTMATTTTRKN 928
VLNMAAEN+ NI I G+VRLVGEVPS + T T T+M EMST++METTTT+AT+T R+
Sbjct: 1347 VLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSEMSTSIMETTTTLATSTARRG 1406
Query: 929 RSTAS---IQPTSDDLVSSAECSSDDEDFVECEPST---ANPTEPGIRR-VPGASEVIRE 981
+ Q T D LV+SAEC SDDED CEPS+ ANPT G R PG++EVIRE
Sbjct: 1407 KPPTKEPISQTTDDILVASAECPSDDEDIDPCEPSSGGLANPTRAGGREPYPGSAEVIRE 1466
Query: 982 SSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDETRNYISNSAQSNGTLMKEK 1041
SSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSY VDE+RNYISNSAQSNG ++KEK
Sbjct: 1467 SSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEK 1526
Query: 1042 QQSS-KSGHKKQKNKDREYYV 1061
Q SS KS +K +KNKD+EYYV
Sbjct: 1527 QPSSAKSSNKNKKNKDKEYYV 1547
Score = 170 bits (431), Expect = 6e-42
Identities = 195/855 (22%), Positives = 342/855 (40%), Gaps = 150/855 (17%)
Query: 88 PKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFAVELL-DGNLYL 146
PKWN +SF +T GL+L+ + DF + L G L L
Sbjct: 44 PKWNACCESEMSFQLKTRSARGLVLYFDDEGF------------CDFLELILTRGGRLQL 91
Query: 147 LLDMGSGTIKVKATQKKANDGEWYHVDIQRDGRSGTISVNSRRTPFT-ASGESEILDLEG 205
+ NDG W+ V I+R R+ T+ ++ + + + +
Sbjct: 92 SFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFS 151
Query: 206 DMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGR------SKNIRQLAEMQNA 259
+++GGLP L L + + G IRD+ ++ S ++ E N+
Sbjct: 152 GLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEPPNS 211
Query: 260 AGVKSSCSRMSAKQCDSYPCKNNAVCKDGWNRFICD------------------------ 295
G S C + ++ + C N VC ++ +CD
Sbjct: 212 GG-GSPCE--AGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEIKFGLQCVLP 268
Query: 296 ------------CTGT-------------------GYWGRTCEREASILSYDGSMYMKII 324
C T G G++ +E I ++ GS Y
Sbjct: 269 VLLHDNDQGKYCCINTAKPLTEKDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYD 328
Query: 325 MPM-VMHTEAEDVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLDCIRINC 383
+ + + +++++ F + + GL++ T SAD + L L G V L++NL
Sbjct: 329 LSQNPIQSSSDEITLSFKTLQRNGLMLHTGK--SADYVNLALKNGAVSLVINL------- 379
Query: 384 NSSKGPETLY--AGQKLNDNEWHTVRVVRRGK---------------SLKLTVDDDV-AE 425
S E L K NDN WH V+V R + S+ ++VD +
Sbjct: 380 -GSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTISVDGILTTT 438
Query: 426 GTMVGDHTRL---EFHNIETGIMTEKRYISVVPSSFIGHLQSLMFNG----LLYIDLCKN 478
G D+T L +F + T S V ++F+G L+ +++ L L K
Sbjct: 439 GYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQ 498
Query: 479 GDIDY-CELKARFGLRNIIA-DPVTFKTKSSYLSLATLQAYTSMHLFFQFKTTSPDGFIL 536
GD F N+ DP+TF+T S++SL A + + F F+TT P+G IL
Sbjct: 499 GDPKMKIHGVVAFKCENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLIL 558
Query: 537 FNSGDGN-------------DFIAVELVKGYIHYVFDLGNGPNVIKGNSDRPLNDNQWHN 583
F+ G DF A+E++ G+++ + D+G+G IK + +ND +W++
Sbjct: 559 FSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALL-KKVNDGEWYH 617
Query: 584 VVITRDNSNTHSLKVDTKVVTQVING-AKNLDLKGDLYMAGLAQG----MYSNLPKLVAS 638
V RD + ++ V+T G ++ LDL +LY+ GL + ++
Sbjct: 618 VDFQRD-GRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALL 676
Query: 639 RDGFQGCLASVDLNGRLPDLINDA-LHRSGQIERGC-EGPSTTCQEDSCANQGVCMQQWE 696
G+ GC+ + ++G+ D+ A + + ++ C + + C + C N G+C W
Sbjct: 677 NYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWN 736
Query: 697 GFTCDCSMTSYSGNQCNDPGATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDG 756
+ CDCS T Y G C + AT + + P T ++ +++ F + G
Sbjct: 737 RYVCDCSGTGYLGRSC-EREATVLSYDGSMFMKIQLPV--VMHTEAEDVSLRFRSQRAYG 793
Query: 757 ILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTP--------VNDGKYHVV 808
IL+ S D L+L ++ G++ + N+ + I+ + P +ND ++H V
Sbjct: 794 ILMATTSRDS-ADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTV 852
Query: 809 RFTRNGGNATLQVDN 823
R R G + L VD+
Sbjct: 853 RVVRRGKSLKLTVDD 867
Score = 38.9 bits (89), Expect = 0.026
Identities = 28/88 (31%), Positives = 45/88 (51%), Gaps = 4/88 (4%)
Query: 756 GILVRIDSAPGLGDFLQLHIEQG-KIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNG 814
G+++ D G DFL+L + +G ++ + F+I + + TPVNDG +H VR R
Sbjct: 65 GLVLYFDDE-GFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQF 123
Query: 815 GNATLQVDNWPVN--EHYPTGRQLTIFN 840
N TL +D E R +T+F+
Sbjct: 124 RNTTLFIDQVEAKWVEVKSKRRDMTVFS 151
>gi|14211536 neurexin 2 isoform alpha-1 precursor [Homo sapiens]
Length = 1712
Score = 1443 bits (3735), Expect = 0.0
Identities = 691/998 (69%), Positives = 821/998 (82%), Gaps = 37/998 (3%)
Query: 1 MLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDIRLELSRLARIADTKMKIY 60
MLGSDDFFY+GGSP+TADLPGSPVSNNFMGCLK+VVYKNND +LELSRLA+ D KMK+
Sbjct: 420 MLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEGDPKMKLQ 479
Query: 61 GEVVFKCENVATLDPINFETPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQE 120
G++ F+CE+VA LDP+ FE+PEA+++LP+W+ KR GSIS DFRTTEPNGL+LF+ G+
Sbjct: 480 GDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAG 539
Query: 121 RKDARSQKNTKVDFFAVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQRDGRS 180
+ D+FA+ELLDG+LYLLLDMGSG IK++A+ +K NDGEW HVD QRDGR
Sbjct: 540 GGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRK 599
Query: 181 GTISVNSRRTPFTASGESEILDLEGDMYLGGLPEN-RAGLILPTELWTAMLNYGYVGCIR 239
G+ISVNSR TPF A+G+SEILDLE ++YLGGLPE R L LP E+WTA L GYVGC+R
Sbjct: 600 GSISVNSRSTPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVR 659
Query: 240 DLFIDGRSKNIRQLAEMQNAAGVKSSCSRMSAKQCDSYPCKNNAVCKDGWNRFICDCTGT 299
DLFIDGRS+++R LAE Q A GV CSR + KQC S PC+N VC++GWNRFICDC GT
Sbjct: 660 DLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCREGWNRFICDCIGT 719
Query: 300 GYWGRTCEREASILSYDGSMYMKIIMPMVMHTEAEDVSFRFMSQRAYGLLVATTSRDSAD 359
G+ GR CEREA++LSYDGSMYMKI++P MHTEAEDVS RFMSQRAYGL++ATTSR+SAD
Sbjct: 720 GFLGRVCEREATVLSYDGSMYMKIMLPNAMHTEAEDVSLRFMSQRAYGLMMATTSRESAD 779
Query: 360 TLRLELDGGRVKLMVNLDCIRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTV 419
TLRLELDGG++KL VNLDC+R+ C SKGPETL+AG KLNDNEWHTVRVVRRGKSL+L+V
Sbjct: 780 TLRLELDGGQMKLTVNLDCLRVGCAPSKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSV 839
Query: 420 DDDVAEGTMVGDHTRLEFHNIETGIMTEKRYISVVPSSFIGHLQSLMFNGLLYIDLCKNG 479
D+ EG M G H RLEFHNIETGIMTE+R+ISVVPS+FIGHL L+FNG Y+D CK+G
Sbjct: 840 DNVTVEGQMAGAHMRLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDG 899
Query: 480 DIDYCELKARFGLRNIIADPVTFKTKSSYLSLATLQAYTSMHLFFQFKTTSPDGFILFNS 539
DI YCEL ARFGLR I+ADPVTFK++SSYL+LATLQAY SMHLFFQFKTT+PDG +LFNS
Sbjct: 900 DITYCELNARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNS 959
Query: 540 GDGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSDRPLNDNQWHNVVITRDNSNTHSLKVD 599
G+GNDFI +ELVKGYIHYVFDLGNGP+++KGNSD+P+NDNQWHNVV++RD N H+LK+D
Sbjct: 960 GNGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKID 1019
Query: 600 TKVVTQVINGAKNLDLKGDLYMAGLAQGMYSNLPKLVASRDGFQGCLASVDLNGRLPDLI 659
++ VTQ NGA+NLDLKG+LY+ GL++ M+SNLPKLVASRDGFQGCLASVDLNGRLPDLI
Sbjct: 1020 SRTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLI 1079
Query: 660 NDALHRSGQIERGCEGPSTTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQCNDPGATY 719
DALHR GQ+ERGC+GPSTTC E+SCANQGVC+QQW+GFTCDC+MTSY G CNDPG TY
Sbjct: 1080 ADALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTY 1139
Query: 720 IFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGK 779
IFGK G LI YTWP NDRPSTR DRLAVGFST + +LVR+DSA GLGD+LQLHI+QG
Sbjct: 1140 IFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGT 1199
Query: 780 IGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPT------- 832
+GV+FN+GT DI+I E V+DGKYHVVRFTR+GGNATLQVD+WPVNE YP
Sbjct: 1200 VGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNFDNER 1259
Query: 833 -----------------------GRQLTIFNTQAQIAIGGKDKGRLFQGQLSGLYYDGLK 869
GRQLTIFN+QA I IGG+D+GR FQGQ+SGLYY+GLK
Sbjct: 1260 LAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLK 1319
Query: 870 VLNMAAENNPNIKINGSVRLVGEVPSILGTTQT--TSMPPEMSTTVMETTTTMATTTTRK 927
VL +AAE++PN++ G +RLVGE PS+L + +T T++ +M+TT+METTTTMATTTTR+
Sbjct: 1320 VLALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATTTTRR 1379
Query: 928 NRS----TASIQPTSDDLVSSAECSSDDEDFVECEPST 961
RS ++ Q T D LV+SAEC SDDED ECEPST
Sbjct: 1380 GRSPTLRDSTTQNTDDLLVASAECPSDDEDLEECEPST 1417
Score = 172 bits (435), Expect = 2e-42
Identities = 201/890 (22%), Positives = 347/890 (38%), Gaps = 147/890 (16%)
Query: 96 GSISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFAVELLDGNLYLLLDMGSGTI 155
G +SF RT L+L+ DF + L+DG L L +
Sbjct: 51 GELSFSLRTNATRALLLYL------------DDGGDCDFLELLLVDGRLRLRFTLSCAEP 98
Query: 156 KVKATQKKANDGEWYHVDIQRDGRSGTISVNSRRTPFTASGESEILDLEGDMYLGGLPEN 215
D W+ V + RD R ++V+ + + + D+++GG+P +
Sbjct: 99 ATLQLDTPVADDRWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPD 158
Query: 216 RAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEMQNAAGVKSSCSRMSAKQCD 275
+ L T + G + +L + R L Q G + A+
Sbjct: 159 VR--LSALTLSTVKYEPPFRGLLANLKLGERPP---ALLGSQGLRGATADPLCAPARN-- 211
Query: 276 SYPCKNNAVCKD-GWNRFICDCTGTGYWGRTCERE----------------ASILSYDGS 318
PC N +C CDC+ TG+ G+ C E S+L +G
Sbjct: 212 --PCANGGLCTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGG 269
Query: 319 ---------------------------MYMKIIMPMVMHTEAEDVSFRFMSQRAYGLLVA 351
+ + + + ++++ F + + GL++
Sbjct: 270 AGRGGAGDVHQPTKGKEEFVATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLH 329
Query: 352 TTSRDSADTLRLELDGGRVKLMVNLDCIRINCNSSKGPETLY--AGQKLNDNEWHTVRVV 409
T SAD + L L G V L++NL S E L K NDN WH VRV
Sbjct: 330 TGK--SADYVNLSLKSGAVWLVINL--------GSGAFEALVEPVNGKFNDNAWHDVRVT 379
Query: 410 RRGKS---------------LKLTVDDDV-AEGTMVGDHTRL---EFHNIETGIMTEKRY 450
R + + ++VD + G D+T L +F I T
Sbjct: 380 RNLRQHAGIGHAMVNKLHYLVTISVDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADLP 439
Query: 451 ISVVPSSFIGHLQSLMFNG----LLYIDLCKNGDIDY-CELKARFGLRNIIA-DPVTFKT 504
S V ++F+G L+ +++ L L K GD + F ++ A DPVTF++
Sbjct: 440 GSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEGDPKMKLQGDLSFRCEDVAALDPVTFES 499
Query: 505 KSSYLSLATLQAYTSMHLFFQFKTTSPDGFILFNSG-------------DGNDFIAVELV 551
++++L A + + F+TT P+G +LF+ G D+ A+EL+
Sbjct: 500 PEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELL 559
Query: 552 KGYIHYVFDLGNGPNVIKGNSDRPLNDNQWHNVVITRDNSNTHSLKVDTKVVTQVING-A 610
G+++ + D+G+G ++ +S R +ND +W +V RD S+ V+++ + G +
Sbjct: 560 DGHLYLLLDMGSGGIKLRASS-RKVNDGEWCHVDFQRD-GRKGSISVNSRSTPFLATGDS 617
Query: 611 KNLDLKGDLYMAGLAQGMYSNLPK-----LVASRDGFQGCLASVDLNGRLPDL--INDAL 663
+ LDL+ +LY+ GL +G +LP A R G+ GC+ + ++GR DL + +A
Sbjct: 618 EILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQ 677
Query: 664 HRSGQIERGCEGPSTTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQCNDPGATYIFGK 723
G C C N GVC + W F CDC T + G C +
Sbjct: 678 GAVGVAPFCSRETLKQCASAPCRNGGVCREGWNRFICDCIGTGFLGRVCEREAT--VLSY 735
Query: 724 SGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVV 783
G + + N T ++ +++ F + G+++ S D L+L ++ G++ +
Sbjct: 736 DGSMYMKIMLPN-AMHTEAEDVSLRFMSQRAYGLMMATTSRES-ADTLRLELDGGQMKLT 793
Query: 784 FNIGTVDISIKEERTP--------VNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGRQ 835
N+ + + + P +ND ++H VR R G + L VDN V
Sbjct: 794 VNLDCLRVGCAPSKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDNVTVEGQMAGAHM 853
Query: 836 LTIFNTQAQIAIGGKDKGRL-------FQGQLSGLYYDGLKVLNMAAENN 878
F+ I G + R F G LSGL ++G ++ + +
Sbjct: 854 RLEFH---NIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDGD 900
Score = 157 bits (396), Expect = 7e-38
Identities = 81/102 (79%), Positives = 90/102 (88%), Gaps = 1/102 (0%)
Query: 961 TANPTEPGIRRVPGASEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQV 1020
TANPT PG R PGA EVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQV
Sbjct: 1611 TANPTGPGERGPPGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQV 1670
Query: 1021 DETRNYISNSAQSNGTLMKEKQQSS-KSGHKKQKNKDREYYV 1061
D++RNYISNSAQSNG ++KEK ++ K+ K +KNKD+EYYV
Sbjct: 1671 DQSRNYISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV 1712
Score = 81.3 bits (199), Expect = 5e-15
Identities = 101/448 (22%), Positives = 177/448 (39%), Gaps = 88/448 (19%)
Query: 516 AYTSMHLFFQFKTTSPDGFILFNSGDGN-DFIAVELVKGYIHYVFDLGNG-PNVIKGNSD 573
A +S L F +T + +L+ G+ DF+ + LV G + F L P ++ D
Sbjct: 47 AASSGELSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQ--LD 104
Query: 574 RPLNDNQWHNVVITRDNSNTHSLKVDTKV-VTQVINGAKNLDLKGDLYMAGLAQGMYSNL 632
P+ D++WH V++TRD T +L VD + +V + + + + DL++ G+ + +
Sbjct: 105 TPVADDRWHMVLLTRDARRT-ALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDVRLSA 163
Query: 633 PKL--VASRDGFQGCLASVDLNGRLPDLINDALHRSGQIERGCEGPSTTCQEDSCANQGV 690
L V F+G LA++ L R P L+ S + P + CAN G+
Sbjct: 164 LTLSTVKYEPPFRGLLANLKLGERPPALLG-----SQGLRGATADPLCAPARNPCANGGL 218
Query: 691 CMQQWEG-FTCDCSMTSYSGNQC---------------NDPGATYIFGKSG--------- 725
C G CDCS T + G C N + +F + G
Sbjct: 219 CTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGGAGRGGAGDV 278
Query: 726 ---------------GLILYTWPANDRP-STRSDRLAVGFSTTVKDGILVRIDSAPGLGD 769
G + + + P + +D + + F T ++G+++ + D
Sbjct: 279 HQPTKGKEEFVATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHTGKS---AD 335
Query: 770 FLQLHIEQGKIGVVFNIGT--VDISIKEERTPVNDGKYHVVRFTRN------GGNA---- 817
++ L ++ G + +V N+G+ + ++ ND +H VR TRN G+A
Sbjct: 336 YVNLSLKSGAVWLVINLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNK 395
Query: 818 -----TLQVDNWPVNEHYPTGRQLTIFNTQAQIAIGGKDK---------GRLFQGQLSGL 863
T+ VD Y T T+ + IGG F G L +
Sbjct: 396 LHYLVTISVDGILTTTGY-TQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDV 454
Query: 864 YYDG----LKVLNMAAENNPNIKINGSV 887
Y L++ +A E +P +K+ G +
Sbjct: 455 VYKNNDFKLELSRLAKEGDPKMKLQGDL 482
>gi|21166380 neurexin 2 isoform alpha-2 precursor [Homo sapiens]
Length = 1642
Score = 1437 bits (3721), Expect = 0.0
Identities = 686/968 (70%), Positives = 814/968 (84%), Gaps = 16/968 (1%)
Query: 1 MLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDIRLELSRLARIADTKMKIY 60
MLGSDDFFY+GGSP+TADLPGSPVSNNFMGCLK+VVYKNND +LELSRLA+ D KMK+
Sbjct: 389 MLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEGDPKMKLQ 448
Query: 61 GEVVFKCENVATLDPINFETPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQE 120
G++ F+CE+VA LDP+ FE+PEA+++LP+W+ KR GSIS DFRTTEPNGL+LF+ G+
Sbjct: 449 GDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAG 508
Query: 121 RKDARSQKNTKVDFFAVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQRDGRS 180
+ D+FA+ELLDG+LYLLLDMGSG IK++A+ +K NDGEW HVD QRDGR
Sbjct: 509 GGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRK 568
Query: 181 GTISVNSRRTPFTASGESEILDLEGDMYLGGLPEN-RAGLILPTELWTAMLNYGYVGCIR 239
G+ISVNSR TPF A+G+SEILDLE ++YLGGLPE R L LP E+WTA L GYVGC+R
Sbjct: 569 GSISVNSRSTPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVR 628
Query: 240 DLFIDGRSKNIRQLAEMQNAAGVKSSCSRMSAKQCDSYPCKNNAVCKDGWNRFICDCTGT 299
DLFIDGRS+++R LAE Q A GV CSR + KQC S PC+N VC++GWNRFICDC GT
Sbjct: 629 DLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCREGWNRFICDCIGT 688
Query: 300 GYWGRTCEREASILSYDGSMYMKIIMPMVMHTEAEDVSFRFMSQRAYGLLVATTSRDSAD 359
G+ GR CEREA++LSYDGSMYMKI++P MHTEAEDVS RFMSQRAYGL++ATTSR+SAD
Sbjct: 689 GFLGRVCEREATVLSYDGSMYMKIMLPNAMHTEAEDVSLRFMSQRAYGLMMATTSRESAD 748
Query: 360 TLRLELDGGRVKLMVNLDCIRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTV 419
TLRLELDGG++KL VNL KGPETL+AG KLNDNEWHTVRVVRRGKSL+L+V
Sbjct: 749 TLRLELDGGQMKLTVNL---------GKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSV 799
Query: 420 DDDVAEGTMVGDHTRLEFHNIETGIMTEKRYISVVPSSFIGHLQSLMFNGLLYIDLCKNG 479
D+ EG M G H RLEFHNIETGIMTE+R+ISVVPS+FIGHL L+FNG Y+D CK+G
Sbjct: 800 DNVTVEGQMAGAHMRLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDG 859
Query: 480 DIDYCELKARFGLRNIIADPVTFKTKSSYLSLATLQAYTSMHLFFQFKTTSPDGFILFNS 539
DI YCEL ARFGLR I+ADPVTFK++SSYL+LATLQAY SMHLFFQFKTT+PDG +LFNS
Sbjct: 860 DITYCELNARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNS 919
Query: 540 GDGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSDRPLNDNQWHNVVITRDNSNTHSLKVD 599
G+GNDFI +ELVKGYIHYVFDLGNGP+++KGNSD+P+NDNQWHNVV++RD N H+LK+D
Sbjct: 920 GNGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKID 979
Query: 600 TKVVTQVINGAKNLDLKGDLYMAGLAQGMYSNLPKLVASRDGFQGCLASVDLNGRLPDLI 659
++ VTQ NGA+NLDLKG+LY+ GL++ M+SNLPKLVASRDGFQGCLASVDLNGRLPDLI
Sbjct: 980 SRTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLI 1039
Query: 660 NDALHRSGQIERGCEGPSTTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQCNDPGATY 719
DALHR GQ+ERGC+GPSTTC E+SCANQGVC+QQW+GFTCDC+MTSY G CNDPG TY
Sbjct: 1040 ADALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTY 1099
Query: 720 IFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGK 779
IFGK G LI YTWP NDRPSTR DRLAVGFST + +LVR+DSA GLGD+LQLHI+QG
Sbjct: 1100 IFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGT 1159
Query: 780 IGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGRQLTIF 839
+GV+FN+GT DI+I E V+DGKYHVVRFTR+GGNATLQVD+WPVNE YP GRQLTIF
Sbjct: 1160 VGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGRQLTIF 1219
Query: 840 NTQAQIAIGGKDKGRLFQGQLSGLYYDGLKVLNMAAENNPNIKINGSVRLVGEVPSILGT 899
N+QA I IGG+D+GR FQGQ+SGLYY+GLKVL +AAE++PN++ G +RLVGE PS+L +
Sbjct: 1220 NSQAAIKIGGRDQGRPFQGQVSGLYYNGLKVLALAAESDPNVRTEGHLRLVGEGPSVLLS 1279
Query: 900 TQT--TSMPPEMSTTVMETTTTMATTTTRKNRS----TASIQPTSDDLVSSAECSSDDED 953
+T T++ +M+TT+METTTTMATTTTR+ RS ++ Q T D LV+SAEC SDDED
Sbjct: 1280 AETTATTLLADMATTIMETTTTMATTTTRRGRSPTLRDSTTQNTDDLLVASAECPSDDED 1339
Query: 954 FVECEPST 961
ECEPST
Sbjct: 1340 LEECEPST 1347
Score = 181 bits (460), Expect = 2e-45
Identities = 199/851 (23%), Positives = 345/851 (40%), Gaps = 109/851 (12%)
Query: 96 GSISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFAVELLDGNLYLLLDMGSGTI 155
G +SF RT L+L+ DF + L+DG L L +
Sbjct: 51 GELSFSLRTNATRALLLYL------------DDGGDCDFLELLLVDGRLRLRFTLSCAEP 98
Query: 156 KVKATQKKANDGEWYHVDIQRDGRSGTISVNSRRTPFTASGESEILDLEGDMYLGGLPEN 215
D W+ V + RD R ++V+ + + + D+++GG+P +
Sbjct: 99 ATLQLDTPVADDRWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPD 158
Query: 216 RAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEMQNAAGVKSSCSRMSAKQCD 275
+ L T + G + +L + R L Q G + A+
Sbjct: 159 VR--LSALTLSTVKYEPPFRGLLANLKLGERPP---ALLGSQGLRGATADPLCAPARN-- 211
Query: 276 SYPCKNNAVCKD-GWNRFICDCTGTGYWGRTCE------------------REASILSYD 316
PC N +C CDC+ TG+ G+ C +E + ++
Sbjct: 212 --PCANGGLCTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEGKEEFVATFK 269
Query: 317 GS-MYMKIIMPMVMHTEAEDVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVN 375
G+ + + + + ++++ F + + GL++ T SAD + L L G V L++N
Sbjct: 270 GNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHTGK--SADYVNLSLKSGAVWLVIN 327
Query: 376 LDCIRINCNSSKGPETLY--AGQKLNDNEWHTVRVVRRGKS------LKLTVDDD---VA 424
L S E L K NDN WH VRV R + +T+ D
Sbjct: 328 L--------GSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVTISVDGILTT 379
Query: 425 EGTMVGDHTRL---EFHNIETGIMTEKRYISVVPSSFIGHLQSLMFNG----LLYIDLCK 477
G D+T L +F I T S V ++F+G L+ +++ L L K
Sbjct: 380 TGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAK 439
Query: 478 NGDIDY-CELKARFGLRNIIA-DPVTFKTKSSYLSLATLQAYTSMHLFFQFKTTSPDGFI 535
GD + F ++ A DPVTF++ ++++L A + + F+TT P+G +
Sbjct: 440 EGDPKMKLQGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLL 499
Query: 536 LFNSG-------------DGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSDRPLNDNQWH 582
LF+ G D+ A+EL+ G+++ + D+G+G ++ +S R +ND +W
Sbjct: 500 LFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASS-RKVNDGEWC 558
Query: 583 NVVITRDNSNTHSLKVDTKVVTQVING-AKNLDLKGDLYMAGLAQGMYSNLPK-----LV 636
+V RD S+ V+++ + G ++ LDL+ +LY+ GL +G +LP
Sbjct: 559 HVDFQRD-GRKGSISVNSRSTPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTA 617
Query: 637 ASRDGFQGCLASVDLNGRLPDL--INDALHRSGQIERGCEGPSTTCQEDSCANQGVCMQQ 694
A R G+ GC+ + ++GR DL + +A G C C N GVC +
Sbjct: 618 ALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCREG 677
Query: 695 WEGFTCDCSMTSYSGNQCNDPGATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVK 754
W F CDC T + G C + G + + N T ++ +++ F +
Sbjct: 678 WNRFICDCIGTGFLGRVCEREAT--VLSYDGSMYMKIMLPN-AMHTEAEDVSLRFMSQRA 734
Query: 755 DGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNG 814
G+++ S D L+L ++ G++ + N+G ++ +ND ++H VR R G
Sbjct: 735 YGLMMATTSRES-ADTLRLELDGGQMKLTVNLGKGPETLFAGH-KLNDNEWHTVRVVRRG 792
Query: 815 GNATLQVDNWPVNEHYPTGRQLTIFNTQAQIAIGGKDKGRL-------FQGQLSGLYYDG 867
+ L VDN V F+ I G + R F G LSGL ++G
Sbjct: 793 KSLQLSVDNVTVEGQMAGAHMRLEFH---NIETGIMTERRFISVVPSNFIGHLSGLVFNG 849
Query: 868 LKVLNMAAENN 878
++ + +
Sbjct: 850 QPYMDQCKDGD 860
Score = 157 bits (396), Expect = 7e-38
Identities = 81/102 (79%), Positives = 90/102 (88%), Gaps = 1/102 (0%)
Query: 961 TANPTEPGIRRVPGASEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQV 1020
TANPT PG R PGA EVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQV
Sbjct: 1541 TANPTGPGERGPPGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQV 1600
Query: 1021 DETRNYISNSAQSNGTLMKEKQQSS-KSGHKKQKNKDREYYV 1061
D++RNYISNSAQSNG ++KEK ++ K+ K +KNKD+EYYV
Sbjct: 1601 DQSRNYISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV 1642
Score = 39.3 bits (90), Expect = 0.020
Identities = 23/81 (28%), Positives = 40/81 (49%), Gaps = 1/81 (1%)
Query: 742 SDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVN 801
S L+ T +L+ +D G DFL+L + G++ + F + + + + TPV
Sbjct: 50 SGELSFSLRTNATRALLLYLDDG-GDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVA 108
Query: 802 DGKYHVVRFTRNGGNATLQVD 822
D ++H+V TR+ L VD
Sbjct: 109 DDRWHMVLLTRDARRTALAVD 129
>gi|41350305 neurexin 3 isoform 2 precursor [Homo sapiens]
Length = 432
Score = 684 bits (1766), Expect = 0.0
Identities = 346/349 (99%), Positives = 346/349 (99%), Gaps = 3/349 (0%)
Query: 716 GATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHI 775
GATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHI
Sbjct: 84 GATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHI 143
Query: 776 EQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGRQ 835
EQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGRQ
Sbjct: 144 EQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGRQ 203
Query: 836 LTIFNTQAQIAIGGKDKGRLFQGQLSGLYYDGLKVLNMAAENNPNIKINGSVRLVGEVPS 895
LTIFNTQAQIAIGGKDKGRLFQGQLSGLYYDGLKVLNMAAENNPNIKINGSVRLVGEVPS
Sbjct: 204 LTIFNTQAQIAIGGKDKGRLFQGQLSGLYYDGLKVLNMAAENNPNIKINGSVRLVGEVPS 263
Query: 896 ILGTTQTTSMPPEMSTTVMETTTTMATTTTRKNRSTASIQPTSDDLVSSAECSSDDEDFV 955
ILGTTQTTSMPPEMSTTVMETTTTMATTTTRKNRSTASIQPTSDDLVSSAECSSDDEDFV
Sbjct: 264 ILGTTQTTSMPPEMSTTVMETTTTMATTTTRKNRSTASIQPTSDDLVSSAECSSDDEDFV 323
Query: 956 ECEPST---ANPTEPGIRRVPGASEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRN 1012
ECEPST ANPTEPGIRRVPGASEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRN
Sbjct: 324 ECEPSTGRSANPTEPGIRRVPGASEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRN 383
Query: 1013 RDEGSYQVDETRNYISNSAQSNGTLMKEKQQSSKSGHKKQKNKDREYYV 1061
RDEGSYQVDETRNYISNSAQSNGTLMKEKQQSSKSGHKKQKNKDREYYV
Sbjct: 384 RDEGSYQVDETRNYISNSAQSNGTLMKEKQQSSKSGHKKQKNKDREYYV 432
Score = 39.7 bits (91), Expect = 0.015
Identities = 41/151 (27%), Positives = 66/151 (43%), Gaps = 19/151 (12%)
Query: 526 FKTTSPDGFIL-FNSGDG-NDFIAVELVKGYIHYVFDLGNGPNVIKGNSDRPLNDNQWHN 583
F TT DG ++ +S G DF+ + + +G I VF++G IK P+ND ++H
Sbjct: 117 FSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIK-EERTPVNDGKYHV 175
Query: 584 VVITRDNSNTHSLKVDTKVVTQVINGAKNLDL-------------KGDLYMAGLAQGMYS 630
V TR+ N +L+VD V + + L + KG L+ L+ Y
Sbjct: 176 VRFTRNGGNA-TLQVDNWPVNEHYPTGRQLTIFNTQAQIAIGGKDKGRLFQGQLSGLYYD 234
Query: 631 NLP--KLVASRDGFQGCLASVDLNGRLPDLI 659
L + A + SV L G +P ++
Sbjct: 235 GLKVLNMAAENNPNIKINGSVRLVGEVPSIL 265
Score = 37.0 bits (84), Expect = 0.099
Identities = 23/92 (25%), Positives = 45/92 (48%), Gaps = 9/92 (9%)
Query: 331 TEAEDVSFRFMSQRAYGLLVATTSRDS-ADTLRLELDGGRVKLMVNLDCIRINCNSSKGP 389
T ++ ++ F + G+LV S D L+L ++ G++ ++ N+ + I+ + P
Sbjct: 108 TRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTP 167
Query: 390 ETLYAGQKLNDNEWHTVRVVRRGKSLKLTVDD 421
+ND ++H VR R G + L VD+
Sbjct: 168 --------VNDGKYHVVRFTRNGGNATLQVDN 191
Score = 35.0 bits (79), Expect = 0.38
Identities = 18/86 (20%), Positives = 43/86 (50%), Gaps = 2/86 (2%)
Query: 133 DFFAVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQRDGRSGTISVNS--RRT 190
DF + + G + ++ ++G+ I +K + NDG+++ V R+G + T+ V++
Sbjct: 137 DFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNE 196
Query: 191 PFTASGESEILDLEGDMYLGGLPENR 216
+ + I + + + +GG + R
Sbjct: 197 HYPTGRQLTIFNTQAQIAIGGKDKGR 222
>gi|157427673 neurexin 3 isoform 3 precursor [Homo sapiens]
Length = 459
Score = 674 bits (1739), Expect = 0.0
Identities = 346/376 (92%), Positives = 346/376 (92%), Gaps = 30/376 (7%)
Query: 716 GATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHI 775
GATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHI
Sbjct: 84 GATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHI 143
Query: 776 EQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTG-- 833
EQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTG
Sbjct: 144 EQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGNT 203
Query: 834 ----------------------------RQLTIFNTQAQIAIGGKDKGRLFQGQLSGLYY 865
RQLTIFNTQAQIAIGGKDKGRLFQGQLSGLYY
Sbjct: 204 DNERFQMVKQKIPFKYNRPVEEWLQEKGRQLTIFNTQAQIAIGGKDKGRLFQGQLSGLYY 263
Query: 866 DGLKVLNMAAENNPNIKINGSVRLVGEVPSILGTTQTTSMPPEMSTTVMETTTTMATTTT 925
DGLKVLNMAAENNPNIKINGSVRLVGEVPSILGTTQTTSMPPEMSTTVMETTTTMATTTT
Sbjct: 264 DGLKVLNMAAENNPNIKINGSVRLVGEVPSILGTTQTTSMPPEMSTTVMETTTTMATTTT 323
Query: 926 RKNRSTASIQPTSDDLVSSAECSSDDEDFVECEPSTANPTEPGIRRVPGASEVIRESSST 985
RKNRSTASIQPTSDDLVSSAECSSDDEDFVECEPSTANPTEPGIRRVPGASEVIRESSST
Sbjct: 324 RKNRSTASIQPTSDDLVSSAECSSDDEDFVECEPSTANPTEPGIRRVPGASEVIRESSST 383
Query: 986 TGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDETRNYISNSAQSNGTLMKEKQQSS 1045
TGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDETRNYISNSAQSNGTLMKEKQQSS
Sbjct: 384 TGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDETRNYISNSAQSNGTLMKEKQQSS 443
Query: 1046 KSGHKKQKNKDREYYV 1061
KSGHKKQKNKDREYYV
Sbjct: 444 KSGHKKQKNKDREYYV 459
Score = 38.9 bits (89), Expect = 0.026
Identities = 28/82 (34%), Positives = 44/82 (53%), Gaps = 4/82 (4%)
Query: 526 FKTTSPDGFIL-FNSGDG-NDFIAVELVKGYIHYVFDLGNGPNVIKGNSDRPLNDNQWHN 583
F TT DG ++ +S G DF+ + + +G I VF++G IK P+ND ++H
Sbjct: 117 FSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIK-EERTPVNDGKYHV 175
Query: 584 VVITRDNSNTHSLKVDTKVVTQ 605
V TR+ N +L+VD V +
Sbjct: 176 VRFTRNGGNA-TLQVDNWPVNE 196
Score = 37.0 bits (84), Expect = 0.099
Identities = 23/92 (25%), Positives = 45/92 (48%), Gaps = 9/92 (9%)
Query: 331 TEAEDVSFRFMSQRAYGLLVATTSRDS-ADTLRLELDGGRVKLMVNLDCIRINCNSSKGP 389
T ++ ++ F + G+LV S D L+L ++ G++ ++ N+ + I+ + P
Sbjct: 108 TRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTP 167
Query: 390 ETLYAGQKLNDNEWHTVRVVRRGKSLKLTVDD 421
+ND ++H VR R G + L VD+
Sbjct: 168 --------VNDGKYHVVRFTRNGGNATLQVDN 191
Score = 34.3 bits (77), Expect = 0.64
Identities = 14/55 (25%), Positives = 32/55 (58%)
Query: 133 DFFAVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQRDGRSGTISVNS 187
DF + + G + ++ ++G+ I +K + NDG+++ V R+G + T+ V++
Sbjct: 137 DFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDN 191
>gi|21070967 neurexin 1 isoform beta precursor [Homo sapiens]
Length = 442
Score = 482 bits (1241), Expect = e-136
Identities = 250/355 (70%), Positives = 289/355 (81%), Gaps = 9/355 (2%)
Query: 716 GATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHI 775
G TYIF K GG I Y WP NDRPSTR+DRLA+GFST K+ +LVR+DS+ GLGD+L+LHI
Sbjct: 88 GTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHI 147
Query: 776 EQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGRQ 835
QGKIGV FN+GT DI+I+E +NDGKYHVVRFTR+GGNATLQVD+WPV E YP GRQ
Sbjct: 148 HQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGRQ 207
Query: 836 LTIFNTQAQIAIGGKDKGRLFQGQLSGLYYDGLKVLNMAAENNPNIKINGSVRLVGEVPS 895
LTIFN+QA I IGGK++G+ FQGQLSGLYY+GLKVLNMAAEN+ NI I G+VRLVGEVPS
Sbjct: 208 LTIFNSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPS 267
Query: 896 ILGTTQT-TSMPPEMSTTVMETTTTMATTTTRKNRSTAS---IQPTSDDLVSSAECSSDD 951
+ T T T+M EMST++METTTT+AT+T R+ + Q T D LV+SAEC SDD
Sbjct: 268 SMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDDILVASAECPSDD 327
Query: 952 EDFVECEPST---ANPTEPGIRR-VPGASEVIRESSSTTGMVVGIVAAAALCILILLYAM 1007
ED CEPS+ ANPT G R PG++EVIRESSSTTGMVVGIVAAAALCILILLYAM
Sbjct: 328 EDIDPCEPSSGGLANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAM 387
Query: 1008 YKYRNRDEGSYQVDETRNYISNSAQSNGTLMKEKQQSS-KSGHKKQKNKDREYYV 1061
YKYRNRDEGSY VDE+RNYISNSAQSNG ++KEKQ SS KS +K +KNKD+EYYV
Sbjct: 388 YKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV 442
Score = 35.0 bits (79), Expect = 0.38
Identities = 38/152 (25%), Positives = 61/152 (40%), Gaps = 15/152 (9%)
Query: 331 TEAEDVSFRFMSQRAYGLLVATTSRDS-ADTLRLELDGGRVKLMVNLDCIRINCNSSKGP 389
T A+ ++ F + + +LV S D L L + G++ + N+ I S
Sbjct: 112 TRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAI 171
Query: 390 ETLYAGQKLNDNEWHTVRVVRRGKSLKLTVDD-DVAEGTMVGDHTRLEFHNIETGIMTEK 448
+ND ++H VR R G + L VD V E G + F++ T I+ K
Sbjct: 172 --------INDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGRQLTI-FNSQATIIIGGK 222
Query: 449 RYISVVPSSFIGHLQSLMFNGLLYIDLCKNGD 480
F G L L +NGL +++ D
Sbjct: 223 EQ----GQPFQGQLSGLYYNGLKVLNMAAEND 250
Score = 31.2 bits (69), Expect = 5.4
Identities = 17/81 (20%), Positives = 40/81 (49%), Gaps = 2/81 (2%)
Query: 133 DFFAVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQRDGRSGTISVNSRRT-- 190
D+ + + G + + ++G+ I ++ + NDG+++ V R G + T+ V+S
Sbjct: 141 DYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIE 200
Query: 191 PFTASGESEILDLEGDMYLGG 211
+ A + I + + + +GG
Sbjct: 201 RYPAGRQLTIFNSQATIIIGG 221
>gi|21166382 neurexin 2 isoform beta precursor [Homo sapiens]
Length = 666
Score = 328 bits (842), Expect = 1e-89
Identities = 170/282 (60%), Positives = 205/282 (72%), Gaps = 36/282 (12%)
Query: 716 GATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHI 775
G TYIFGK G LI YTWP NDRPSTR DRLAVGFST + +LVR+DSA GLGD+LQLHI
Sbjct: 90 GTTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHI 149
Query: 776 EQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPT--- 832
+QG +GV+FN+GT DI+I E V+DGKYHVVRFTR+GGNATLQVD+WPVNE YP
Sbjct: 150 DQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNF 209
Query: 833 ---------------------------GRQLTIFNTQAQIAIGGKDKGRLFQGQLSGLYY 865
GRQLTIFN+QA I IGG+D+GR FQGQ+SGLYY
Sbjct: 210 DNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYY 269
Query: 866 DGLKVLNMAAENNPNIKINGSVRLVGEVPSILGTTQT--TSMPPEMSTTVMETTTTMATT 923
+GLKVL +AAE++PN++ G +RLVGE PS+L + +T T++ +M+TT+METTTTMATT
Sbjct: 270 NGLKVLALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATT 329
Query: 924 TTRKNRS----TASIQPTSDDLVSSAECSSDDEDFVECEPST 961
TTR+ RS ++ Q T D LV+SAEC SDDED ECEPST
Sbjct: 330 TTRRGRSPTLRDSTTQNTDDLLVASAECPSDDEDLEECEPST 371
Score = 157 bits (396), Expect = 7e-38
Identities = 81/102 (79%), Positives = 90/102 (88%), Gaps = 1/102 (0%)
Query: 961 TANPTEPGIRRVPGASEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQV 1020
TANPT PG R PGA EVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQV
Sbjct: 565 TANPTGPGERGPPGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQV 624
Query: 1021 DETRNYISNSAQSNGTLMKEKQQSS-KSGHKKQKNKDREYYV 1061
D++RNYISNSAQSNG ++KEK ++ K+ K +KNKD+EYYV
Sbjct: 625 DQSRNYISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV 666
>gi|7662350 cell recognition molecule Caspr2 precursor [Homo sapiens]
Length = 1331
Score = 154 bits (388), Expect = 6e-37
Identities = 161/574 (28%), Positives = 244/574 (42%), Gaps = 110/574 (19%)
Query: 501 TFKTKSSYLSLATLQAYTSMHLFFQFKTTSPDGFILFNSGDGNDFIAVELVKGY-IHYVF 559
+F SSYL +T Q TS + F FKT +P G L N G DFI +EL + + F
Sbjct: 802 SFPNPSSYLHFSTFQGETSADISFYFKTLTPWGVFLENMGK-EDFIKLELKSATEVSFSF 860
Query: 560 DLGNGPNVIKGNSDRPLNDNQWHNVVITRDNSNTHSLKVDT---KVVTQVINGAKNLDLK 616
D+GNGP I S PLND+QWH V R N SL+VD ++ G L+L
Sbjct: 861 DVGNGPVEIVVRSPTPLNDDQWHRVTAER-NVKQASLQVDRLPQQIRKAPTEGHTRLELY 919
Query: 617 GDLYMAGLAQGMYSNLPKLVASRDGFQGCLASVDLNGRLPDLINDALHRSGQIERGCEGP 676
L++ G + GF GC+ S+ +NG DL A SG I GC G
Sbjct: 920 SQLFVGG------------AGGQQGFLGCIRSLRMNGVTLDLEERAKVTSGFIS-GCSGH 966
Query: 677 STTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQCN-DPGATYIFGKSGGLILYTWPA- 734
T+ +C N G C++++ G++CDCS T+Y G CN D GA F + G + Y + A
Sbjct: 967 CTS-YGTNCENGGKCLERYHGYSCDCSNTAYDGTFCNKDVGA---FFEEGMWLRYNFQAP 1022
Query: 735 ------------------NDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIE 776
N P + + FSTT IL+ I S DFL + ++
Sbjct: 1023 ATNARDSSSRVDNAPDQQNSHPDLAQEEIRFSFSTTKAPCILLYISSF--TTDFLAVLVK 1080
Query: 777 -QGKIGVVFNIGTV--DISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWP-VNEHYPT 832
G + + +N+G +I + + +G+ H V TR+ L++D++P V+ H P+
Sbjct: 1081 PTGSLQIRYNLGGTREPYNIDVDHRNMANGQPHSVNITRHEKTIFLKLDHYPSVSYHLPS 1140
Query: 833 GRQLTIFNTQAQIAIGGK-DKGRL-----------FQGQLSGLYYDGLKVLNMAAENNPN 880
T+FN+ + +G + G++ F G LS + ++ + L A
Sbjct: 1141 SSD-TLFNSPKSLFLGKVIETGKIDQEIHKYNTPGFTGCLSRVQFNQIAPLKAALRQT-- 1197
Query: 881 IKINGSVRLVGE-VPSILGTTQTTSMPPEMSTTVMETTTTMATTTTRKNRSTASIQPTSD 939
+ V + GE V S G + T P +T P
Sbjct: 1198 -NASAHVHIQGELVESNCGASPLTLSPMSSAT-----------------------DPWHL 1233
Query: 940 DLVSSAECSSDDEDFVECEPSTANPTEPGIRRVPGASEVIRESSSTTGMVVGIVAAAALC 999
D + SA DF P PG + + +S+ G V+ +V LC
Sbjct: 1234 DHLDSASA-----DF---------PYNPG--QGQAIRNGVNRNSAIIGGVIAVVIFTILC 1277
Query: 1000 ILILLYAMYKYRNRDEGSYQVDETRNYISNSAQS 1033
L+ L +Y R +G+Y +E + + SA+S
Sbjct: 1278 TLVFL---IRYMFRHKGTYHTNEAKG--AESAES 1306
Score = 108 bits (271), Expect = 2e-23
Identities = 99/426 (23%), Positives = 181/426 (42%), Gaps = 22/426 (5%)
Query: 298 GTGYWGRTCEREASILSYDGSMYMKI-IMPMVMHTEAEDVSFRFMSQRAYGLLVATTSRD 356
G YW A ++++DG + + M T + ++ F + + G+++ +
Sbjct: 180 GCSYW-------ADVINFDGHVVLPYRFRNKKMKTLKDVIALNFKTSESEGVILHGEGQQ 232
Query: 357 SADTLRLELDGGRVKLMVNLDCIRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLK 416
D + LEL ++ L +NL ++ G ++ G L+D+ WH+V + R+G+S+
Sbjct: 233 G-DYITLELKKAKLVLSLNLGSNQLG--PIYGHTSVMTGSLLDDHHWHSVVIERQGRSIN 289
Query: 417 LTVDDDVAEGTMVG--DHTRLEFHNIETGIMTEKRYISVVPSSFIGHLQSLMFNGLLYID 474
LT+D + G D+ L++ GI + S +F G ++S+ +NG+ D
Sbjct: 290 LTLDRSMQHFRTNGEFDYLDLDYEITFGGIPFSGKPSSSSRKNFKGCMESINYNGVNITD 349
Query: 475 LCKNGDIDYCEL-KARFGLRNIIADPVTFKTKSSYLSLATLQAYTSMHLFFQFKTTSPDG 533
L + ++ + F PV F +SYL + + FQF+T +P+G
Sbjct: 350 LARRKKLEPSNVGNLSFSCVEPYTVPVFFNA-TSYLEVPGRLNQDLFSVSFQFRTWNPNG 408
Query: 534 FILFNS-GDGNDFIAVELVKGYIHYVFDLGNGP-NVIKGNSDRPLNDNQWHNVVITRDNS 591
++F+ D + ++L + + ++ + I +S LND QWH V
Sbjct: 409 LLVFSHFADNLGNVEIDLTESKVGVHINITQTKMSQIDISSGSGLNDGQWHEVRFLA-KE 467
Query: 592 NTHSLKVDTKVVTQVINGAKNLDLKGDLYMAGLAQGMYSNLPKLVASRDGFQGCLASVDL 651
N L +D + V + G+ Y G +N V + FQGC+ + +
Sbjct: 468 NFAILTIDGDEASAVRTNSPLQVKTGEKYFFGGFLNQMNNSSHSVL-QPSFQGCMQLIQV 526
Query: 652 NGRLPDLINDALHRSGQIERGCEGPSTT---CQEDSCANQGVCMQQWEGFTCDCSMTSYS 708
+ +L +L A + G C + C + G C Q W+ F C C T YS
Sbjct: 527 DDQLVNLYEVAQRKPGSFANVSIDMCAIIDRCVPNHCEHGGKCSQTWDSFKCTCDETGYS 586
Query: 709 GNQCND 714
G C++
Sbjct: 587 GATCHN 592
Score = 78.6 bits (192), Expect = 3e-14
Identities = 83/363 (22%), Positives = 150/363 (41%), Gaps = 81/363 (22%)
Query: 74 DPINFETPEAYISLP-KWNTKRMGS----ISFDFRTTEPNGLILFTHGKPQERKDARSQK 128
D INF+ ++ LP ++ K+M + I+ +F+T+E G+IL HG+ Q+
Sbjct: 186 DVINFD---GHVVLPYRFRNKKMKTLKDVIALNFKTSESEGVIL--HGEGQQG------- 233
Query: 129 NTKVDFFAVELLDGNLYLLLDMGSGTI------KVKATQKKANDGEWYHVDIQRDGRSGT 182
D+ +EL L L L++GS + T +D W+ V I+R GRS
Sbjct: 234 ----DYITLELKKAKLVLSLNLGSNQLGPIYGHTSVMTGSLLDDHHWHSVVIERQGRSIN 289
Query: 183 ISVNSRRTPFTASGESEILDLEGDMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLF 242
++++ F +GE + LDL+ ++ GG+P
Sbjct: 290 LTLDRSMQHFRTNGEFDYLDLDYEITFGGIP----------------------------- 320
Query: 243 IDGRSKNIRQLAEMQNAAGVKSSCSRMSAKQCDSYPCKNNAVCKDGWNRFICDCTGTGYW 302
+G SS SR + K C N D R + + G
Sbjct: 321 ----------------FSGKPSSSSRKNFKGCMESINYNGVNITDLARRKKLEPSNVGNL 364
Query: 303 GRTCEREASI-LSYDGSMYMKIIMPMVMHTEAEDVSFRFMSQRAYGLLVATTSRDSADTL 361
+C ++ + ++ + Y+++ P ++ + VSF+F + GLLV + D+ +
Sbjct: 365 SFSCVEPYTVPVFFNATSYLEV--PGRLNQDLFSVSFQFRTWNPNGLLVFSHFADNLGNV 422
Query: 362 RLELDGGRVKLMVNLDCIRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTVDD 421
++L +V + +N+ + + +G LND +WH VR + + LT+D
Sbjct: 423 EIDLTESKVGVHINI------TQTKMSQIDISSGSGLNDGQWHEVRFLAKENFAILTIDG 476
Query: 422 DVA 424
D A
Sbjct: 477 DEA 479
Score = 78.2 bits (191), Expect = 4e-14
Identities = 70/308 (22%), Positives = 122/308 (39%), Gaps = 46/308 (14%)
Query: 11 GGSPSTADLPGSPVSNNFMGCLKEVVYKNNDIRLELSRLARIADTKMKIYGEVVFKCENV 70
GG P + P S NF GC++ + Y + ++ LAR + G + F C
Sbjct: 317 GGIPFSGK-PSSSSRKNFKGCMESINYNG----VNITDLARRKKLEPSNVGNLSFSCVEP 371
Query: 71 ATLDPINFETPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKDARSQKNT 130
T+ P+ F +Y+ +P + + S+SF FRT PNGL++F+H
Sbjct: 372 YTV-PVFFNAT-SYLEVPGRLNQDLFSVSFQFRTWNPNGLLVFSH--------------- 414
Query: 131 KVDFFAVELLDGNLYLLLDMGSGTIKVKATQKK-----------ANDGEWYHVDIQRDGR 179
FA L GN+ + L + + TQ K NDG+W+ V
Sbjct: 415 ----FADNL--GNVEIDLTESKVGVHINITQTKMSQIDISSGSGLNDGQWHEVRFLAKEN 468
Query: 180 SGTISVNSRRTPFTASGESEILDLEGDMYLGGLPENRAGLILPTELWTAMLNYGYVGCIR 239
++++ + + + GG L ++L + GC++
Sbjct: 469 FAILTIDGDEASAVRTNSPLQVKTGEKYFFGGF------LNQMNNSSHSVLQPSFQGCMQ 522
Query: 240 DLFIDGRSKNIRQLAEMQNAAGVKSSCSRMS-AKQCDSYPCKNNAVCKDGWNRFICDCTG 298
+ +D + N+ ++A+ + + S + +C C++ C W+ F C C
Sbjct: 523 LIQVDDQLVNLYEVAQRKPGSFANVSIDMCAIIDRCVPNHCEHGGKCSQTWDSFKCTCDE 582
Query: 299 TGYWGRTC 306
TGY G TC
Sbjct: 583 TGYSGATC 590
Score = 76.3 bits (186), Expect = 1e-13
Identities = 98/471 (20%), Positives = 182/471 (38%), Gaps = 86/471 (18%)
Query: 77 NFETPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFA 136
+F P +Y+ + + ISF F+T P G+ L GK DF
Sbjct: 802 SFPNPSSYLHFSTFQGETSADISFYFKTLTPWGVFLENMGKE--------------DFIK 847
Query: 137 VELLDGN-LYLLLDMGSGTIKVKA-TQKKANDGEWYHVDIQRDGRSGTISVNS-----RR 189
+EL + D+G+G +++ + ND +W+ V +R+ + ++ V+ R+
Sbjct: 848 LELKSATEVSFSFDVGNGPVEIVVRSPTPLNDDQWHRVTAERNVKQASLQVDRLPQQIRK 907
Query: 190 TPFTASGESEILDLEGDMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKN 249
P G + L+L +++GG + G++GCIR L ++G + +
Sbjct: 908 AP--TEGHTR-LELYSQLFVGGAGGQQ----------------GFLGCIRSLRMNGVTLD 948
Query: 250 IRQLAEMQNAAGVKSSCSRMSAKQCDSYP--CKNNAVCKDGWNRFICDCTGTGYWGRTCE 307
+ + A++ +G S CS C SY C+N C + ++ + CDC+ T Y G C
Sbjct: 949 LEERAKV--TSGFISGCSG----HCTSYGTNCENGGKCLERYHGYSCDCSNTAYDGTFCN 1002
Query: 308 REASILSYDGSMYMKIIMPMVMHTE--------------------AEDVSFRFMSQRAYG 347
++ +G + E++ F F + +A
Sbjct: 1003 KDVGAFFEEGMWLRYNFQAPATNARDSSSRVDNAPDQQNSHPDLAQEEIRFSFSTTKAPC 1062
Query: 348 LLVATTSRDSADTLRLELDGGRVKLMVNLDCIRINCNSSKGPETLYAGQKLNDNEWHTVR 407
+L+ +S + L G +++ NL R N + GQ H+V
Sbjct: 1063 ILLYISSFTTDFLAVLVKPTGSLQIRYNLGGTREPYNIDVDHRNMANGQP------HSVN 1116
Query: 408 VVRRGKSLKLTVDDDVAEGTMVGDHTRLEFHN---------IETGIMTEKRYISVVPSSF 458
+ R K++ L +D + + + F++ IETG + ++ + P F
Sbjct: 1117 ITRHEKTIFLKLDHYPSVSYHLPSSSDTLFNSPKSLFLGKVIETGKIDQEIHKYNTP-GF 1175
Query: 459 IGHLQSLMFNGL--LYIDLCKNGDIDYCELKARFGLRNIIADPVTFKTKSS 507
G L + FN + L L + + ++ N A P+T SS
Sbjct: 1176 TGCLSRVQFNQIAPLKAALRQTNASAHVHIQGELVESNCGASPLTLSPMSS 1226
Score = 62.4 bits (150), Expect = 2e-09
Identities = 84/314 (26%), Positives = 135/314 (42%), Gaps = 71/314 (22%)
Query: 526 FKTTSPDGFILFNSGDGNDFIAVELVKGYIHYVFDLGN---GP-----NVIKGNSDRPLN 577
FKT+ +G IL G D+I +EL K + +LG+ GP +V+ G+ L+
Sbjct: 216 FKTSESEGVILHGEGQQGDYITLELKKAKLVLSLNLGSNQLGPIYGHTSVMTGSL---LD 272
Query: 578 DNQWHNVVITRDNSNTHSLKVDTKVVTQVINGAKN-LDLKGDLYMAGLAQGMYSNLPKLV 636
D+ WH+VVI R + + L +D + NG + LDL ++ G+ +S P
Sbjct: 273 DHHWHSVVIERQGRSIN-LTLDRSMQHFRTNGEFDYLDLDYEITFGGIP---FSGKPSS- 327
Query: 637 ASRDGFQGCLASVDLNG-RLPDLINDALHRSGQIERGCEGPSTTCQEDSCANQGVCMQQW 695
+SR F+GC+ S++ NG + DL R ++E PS
Sbjct: 328 SSRKNFKGCMESINYNGVNITDLA-----RRKKLE-----PSNV---------------- 361
Query: 696 EGFTCDCSMTSYSGNQCNDPGATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFS--TTV 753
S+S C +P +F + + N D +V F T
Sbjct: 362 -------GNLSFS---CVEPYTVPVFFNATSYLEVPGRLNQ------DLFSVSFQFRTWN 405
Query: 754 KDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNI-----GTVDISIKEERTPVNDGKYHVV 808
+G+LV A LG+ +++ + + K+GV NI +DIS + +NDG++H V
Sbjct: 406 PNGLLVFSHFADNLGN-VEIDLTESKVGVHINITQTKMSQIDIS---SGSGLNDGQWHEV 461
Query: 809 RFTRNGGNATLQVD 822
RF A L +D
Sbjct: 462 RFLAKENFAILTID 475
Score = 45.1 bits (105), Expect = 4e-04
Identities = 32/154 (20%), Positives = 69/154 (44%), Gaps = 18/154 (11%)
Query: 735 NDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIK 794
N + T D +A+ F T+ +G+++ + GD++ L +++ K+ + N+G+ +
Sbjct: 202 NKKMKTLKDVIALNFKTSESEGVILHGEGQQ--GDYITLELKKAKLVLSLNLGSNQLGPI 259
Query: 795 EERTPV------NDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGRQLTIFNTQAQIAIG 848
T V +D +H V R G + L +D +H+ T + + +I G
Sbjct: 260 YGHTSVMTGSLLDDHHWHSVVIERQGRSINLTLDR--SMQHFRTNGEFDYLDLDYEITFG 317
Query: 849 G--------KDKGRLFQGQLSGLYYDGLKVLNMA 874
G + F+G + + Y+G+ + ++A
Sbjct: 318 GIPFSGKPSSSSRKNFKGCMESINYNGVNITDLA 351
>gi|116284404 cell recognition protein CASPR4 isoform 1 [Homo
sapiens]
Length = 1308
Score = 125 bits (315), Expect = 2e-28
Identities = 108/429 (25%), Positives = 188/429 (43%), Gaps = 38/429 (8%)
Query: 306 CEREASILSYDGSMYMKIIMPMVMHTEAEDV-SFRFMSQRAYGLLVATTSRDSADTLRLE 364
C + ++ DG + + +D+ S +F + ++ G+L+ + D + L+
Sbjct: 177 CAYRSEVVDLDGKSSLLYRFDQKSLSPIKDIISLKFKTMQSDGILLHREG-PNGDHITLQ 235
Query: 365 LDGGRVKLMVNLDCIRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTVDDDVA 424
L R+ L++N ++ S+ TL G L+D WH+V + R GK + TVD+
Sbjct: 236 LRRARLFLLINSGEAKLPSTSTLVNLTL--GSLLDDQHWHSVLIQRLGKQVNFTVDEHRH 293
Query: 425 EGTMVGDHT--RLEFHNIETGIMTEKRYISVVPSSFIGHLQSLMFNGLLYIDLCKNGDID 482
G+ L++ GI + +S +F G L++L +NG+ IDL K
Sbjct: 294 HFHARGEFNLMNLDYEISFGGIPAPGKSVSFPHRNFHGCLENLYYNGVDIIDLAKQQKPQ 353
Query: 483 YCEL-KARFGLRNIIADPVTFKTKSSYLSLATLQAYTSMHLFFQFKTTSPDGFILFNSGD 541
+ F + PVTF + SYL+L + FQF+T + G +LF+
Sbjct: 354 IIAMGNVSFSCSQPQSMPVTFLSSRSYLALPDFSGEEEVSATFQFRTWNKAGLLLFSE-- 411
Query: 542 GNDFIAVELVKGYIHYVFDLGNGPNVIKGNSDRP------------LNDNQWHNVVITRD 589
++L+ G I G +K N +P LND QWH+V ++
Sbjct: 412 ------LQLISGGILLFLSDGK----LKSNLYQPGKLPSDITAGVELNDGQWHSVSLSA- 460
Query: 590 NSNTHSLKVDTKVVTQV-INGAKNLDLKGDLYMAGLAQGMYSNLPKLVASRDGFQGCLAS 648
N S+ VD ++ + + G + + G Y G + + K + GFQGC+
Sbjct: 461 KKNHLSVAVDGQMASAAPLLGPEQIYSGGTYYFGGCPDKSFGS--KCKSPLGGFQGCMRL 518
Query: 649 VDLNGRLPDLIN---DALHRSGQIERGCEGPSTTCQEDSCANQGVCMQQWEGFTCDCSMT 705
+ ++G++ DLI+ +L ++ G S C + C + G C Q W F C+C+ T
Sbjct: 519 ISISGKVVDLISVQQGSLGNFSDLQIDSCGISDRCLPNYCEHGGECSQSWSTFHCNCTNT 578
Query: 706 SYSGNQCND 714
Y G C++
Sbjct: 579 GYRGATCHN 587
Score = 119 bits (299), Expect = 1e-26
Identities = 142/577 (24%), Positives = 233/577 (40%), Gaps = 92/577 (15%)
Query: 501 TFKTKSSYLSLATLQAYTSMHLFFQFKTTSPDGFILFNSGDGNDFIAVELVKG-YIHYVF 559
+F T++SYL T S + F FKTT+ G L N G DFI +EL + + F
Sbjct: 796 SFDTEASYLHFPTFHGELSADVSFFFKTTASSGVFLENLGIA-DFIRIELRSPTVVTFSF 854
Query: 560 DLGNGPNVIKGNSDRPLNDNQWHNVVITRDNSNTHSLKVD---TKVVTQVINGAKNLDLK 616
D+GNGP I S NDNQWH+V + R N SL+VD K +G L L
Sbjct: 855 DVGNGPFEISVQSPTHFNDNQWHHVRVER-NMKEASLQVDQLTPKTQPAPADGHVLLQLN 913
Query: 617 GDLYMAGLAQGMYSNLPKLVASRDGFQGCLASVDLNGRLPDLINDALHRSGQIERGCEGP 676
L++ G A + GF GC+ S+ LNG DL + + +++ GC G
Sbjct: 914 SQLFVGGTA-----------TRQRGFLGCIRSLQLNGMTLDL-EERAQVTPEVQPGCRGH 961
Query: 677 STTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQCNDPGATYIFGKSGGLILYTWPAND 736
++ + C N G C ++ GF CDC+ ++Y+G C++ + Y FG SG ++Y + N
Sbjct: 962 CSSYGK-LCRNGGKCRERPIGFFCDCTFSAYTGPFCSNEISAY-FG-SGSSVIYNFQENY 1018
Query: 737 RPSTRSDRLAVGFSTTVKDG-----ILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDI 791
S S A F +K R P L F+ ++ ++ G++ I
Sbjct: 1019 LLSKNSSSHAASFHGDMKLSREMIKFSFRTTRTPSLLLFVSSFYKEYLSVIIAKNGSLQI 1078
Query: 792 SIK----EERTPVN-------DGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGRQLTIFN 840
K +E VN DG+ H + R G +++D+ N
Sbjct: 1079 RYKLNKYQEPDVVNFDFKNMADGQLHHIMINREEGVVFIEIDD----------------N 1122
Query: 841 TQAQIAIGGKDKGRLFQGQLSGLYYDGLK--VLNMAAENNPNIKINGSVRLVGE--VPSI 896
+ Q+ + SG + +K VL E++ ++ L G
Sbjct: 1123 RRRQVHLS------------SGTEFSAVKSLVLGRILEHS---DVDQDTALAGAQGFTGC 1167
Query: 897 LGTTQTTSMPPEMSTTVMETTTTMATTTTRKNRSTASIQPTSDDLVSSAECSSDDEDFVE 956
L Q + + P + + + T T S+ QP +D +S E + D
Sbjct: 1168 LSAVQLSHVAP-LKAALHPSHPDPVTVTGHVTESSCMAQPGTD--ATSRERTHSFAD--- 1221
Query: 957 CEPSTANPTEPGIRRVPGASEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEG 1016
T + EP + I+ S+ G ++ +V LCI + +Y+ +
Sbjct: 1222 -HSGTIDDREP-------LANAIKSDSAVIGGLIAVVIFILLCITAIAVRIYQQKR---- 1269
Query: 1017 SYQVDETRNYISNSAQSNGTLMKEKQQSSKSGHKKQK 1053
Y+ E + S + S ++K + + ++ QK
Sbjct: 1270 LYKRSEAKR--SENVDSAEAVLKSELNIQNAVNENQK 1304
Score = 93.6 bits (231), Expect = 9e-19
Identities = 78/310 (25%), Positives = 131/310 (42%), Gaps = 51/310 (16%)
Query: 11 GGSPSTADLPGSPVS---NNFMGCLKEVVYKNNDIRLELSRLARIADTKMKIYGEVVFKC 67
GG P+ PG VS NF GCL+ + Y DI LA+ ++ G V F C
Sbjct: 313 GGIPA----PGKSVSFPHRNFHGCLENLYYNGVDI----IDLAKQQKPQIIAMGNVSFSC 364
Query: 68 ENVATLDPINFETPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKDARSQ 127
++ P+ F + +Y++LP ++ + S +F FRT GL+LF+
Sbjct: 365 SQPQSM-PVTFLSSRSYLALPDFSGEEEVSATFQFRTWNKAGLLLFSE------------ 411
Query: 128 KNTKVDFFAVELLDGNLYLLLDMGSGTIKVKATQK---------KANDGEWYHVDIQRDG 178
++L+ G + L L G + K + NDG+W+ V +
Sbjct: 412 ---------LQLISGGILLFLSDGKLKSNLYQPGKLPSDITAGVELNDGQWHSVSLSAKK 462
Query: 179 RSGTISVNSRRTPFTASGESEILDLEGDMYLGGLPENRAGLILPTELWTAMLNYGYVGCI 238
+++V+ + E + G Y GG P+ G + L G+ GC+
Sbjct: 463 NHLSVAVDGQMASAAPLLGPEQIYSGGTYYFGGCPDKSFGSKCKSPLG------GFQGCM 516
Query: 239 RDLFIDGRSKNIR--QLAEMQNAAGVKSSCSRMSAKQCDSYPCKNNAVCKDGWNRFICDC 296
R + I G+ ++ Q + N + ++ +S + +Y C++ C W+ F C+C
Sbjct: 517 RLISISGKVVDLISVQQGSLGNFSDLQIDSCGISDRCLPNY-CEHGGECSQSWSTFHCNC 575
Query: 297 TGTGYWGRTC 306
T TGY G TC
Sbjct: 576 TNTGYRGATC 585
Score = 85.1 bits (209), Expect = 3e-16
Identities = 63/249 (25%), Positives = 112/249 (44%), Gaps = 43/249 (17%)
Query: 77 NFETPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFA 136
+F+T +Y+ P ++ + +SF F+TT +G+ L G DF
Sbjct: 796 SFDTEASYLHFPTFHGELSADVSFFFKTTASSGVFLENLGI--------------ADFIR 841
Query: 137 VELLDGNLYLL-LDMGSGTIKVKA-TQKKANDGEWYHVDIQRDGRSGTISVNSRRTPFTA 194
+EL + D+G+G ++ + ND +W+HV ++R+ + ++ V+ + TP T
Sbjct: 842 IELRSPTVVTFSFDVGNGPFEISVQSPTHFNDNQWHHVRVERNMKEASLQVD-QLTPKTQ 900
Query: 195 SGESE---ILDLEGDMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIR 251
++ +L L +++GG TA G++GCIR L ++G + ++
Sbjct: 901 PAPADGHVLLQLNSQLFVGG---------------TATRQRGFLGCIRSLQLNGMTLDLE 945
Query: 252 QLAEMQNAAGVKSSCSRMSAKQCDSYP--CKNNAVCKDGWNRFICDCTGTGYWGRTCERE 309
+ A++ V+ C C SY C+N C++ F CDCT + Y G C E
Sbjct: 946 ERAQV--TPEVQPGCRG----HCSSYGKLCRNGGKCRERPIGFFCDCTFSAYTGPFCSNE 999
Query: 310 ASILSYDGS 318
S GS
Sbjct: 1000 ISAYFGSGS 1008
Score = 66.6 bits (161), Expect = 1e-10
Identities = 77/336 (22%), Positives = 132/336 (39%), Gaps = 78/336 (23%)
Query: 98 ISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFAVELLDGNLYLLLDMGSGTIKV 157
IS F+T + +G++L G D ++L L+LL++ SG K+
Sbjct: 208 ISLKFKTMQSDGILLHREGP-------------NGDHITLQLRRARLFLLIN--SGEAKL 252
Query: 158 KATQKKAN--------DGEWYHVDIQRDGRSGTISVNSRRTPFTASGESEILDLEGDMYL 209
+T N D W+ V IQR G+ +V+ R F A GE +++L+ ++
Sbjct: 253 PSTSTLVNLTLGSLLDDQHWHSVLIQRLGKQVNFTVDEHRHHFHARGEFNLMNLDYEISF 312
Query: 210 GGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEMQNAAGVKSSCSRM 269
GG+P + P + + GC+ +L+ +G +I LA+ Q +
Sbjct: 313 GGIPAPGKSVSFP--------HRNFHGCLENLYYNG--VDIIDLAKQQKPQIIAMGNVSF 362
Query: 270 SAKQCDSYPCKNNAVCKDGWNRFICDCTGTGYWGRTCEREASILSYDGSMYMKIIMPMVM 329
S Q S P F+ S SY + +P
Sbjct: 363 SCSQPQSMPV-----------TFL-----------------SSRSY-------LALPDFS 387
Query: 330 HTEAEDVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLDCIRINC-NSSKG 388
E +F+F + GLL+ + L+L G + L ++ ++ N K
Sbjct: 388 GEEEVSATFQFRTWNKAGLLLFS---------ELQLISGGILLFLSDGKLKSNLYQPGKL 438
Query: 389 PETLYAGQKLNDNEWHTVRVVRRGKSLKLTVDDDVA 424
P + AG +LND +WH+V + + L + VD +A
Sbjct: 439 PSDITAGVELNDGQWHSVSLSAKKNHLSVAVDGQMA 474
Score = 57.0 bits (136), Expect = 9e-08
Identities = 90/393 (22%), Positives = 151/393 (38%), Gaps = 83/393 (21%)
Query: 335 DVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLDCIRINCNSSKGPE--TL 392
DVSF F + + G+ + AD +R+EL V + + + GP ++
Sbjct: 816 DVSFFFKTTASSGVFLENLG--IADFIRIELRSPTV--------VTFSFDVGNGPFEISV 865
Query: 393 YAGQKLNDNEWHTVRVVRRGKSLKLTVDD--DVAEGTMVGDHTRLEFHN--IETGIMTEK 448
+ NDN+WH VRV R K L VD + H L+ ++ G T +
Sbjct: 866 QSPTHFNDNQWHHVRVERNMKEASLQVDQLTPKTQPAPADGHVLLQLNSQLFVGGTATRQ 925
Query: 449 RYISVVPSSFIGHLQSLMFNGLL-----------------------YIDLCKNGDI---- 481
R F+G ++SL NG+ Y LC+NG
Sbjct: 926 R-------GFLGCIRSLQLNGMTLDLEERAQVTPEVQPGCRGHCSSYGKLCRNGGKCRER 978
Query: 482 ---------------DYC--ELKARFG-----LRNIIADPVTFKTKSSYLSLATLQAYTS 519
+C E+ A FG + N + + K SS+ + S
Sbjct: 979 PIGFFCDCTFSAYTGPFCSNEISAYFGSGSSVIYNFQENYLLSKNSSSHAASFHGDMKLS 1038
Query: 520 MHLF-FQFKTTSPDGFILFNSGDGNDFIAVELVKG---YIHYVFDLGNGPNVIKGNSD-R 574
+ F F+TT +LF S ++++V + K I Y + P+V+ N D +
Sbjct: 1039 REMIKFSFRTTRTPSLLLFVSSFYKEYLSVIIAKNGSLQIRYKLNKYQEPDVV--NFDFK 1096
Query: 575 PLNDNQWHNVVITRDNSNTHSLKVDTKVVTQV-INGAKNLDLKGDLYMAGLAQGMYSNLP 633
+ D Q H+++I R+ +++D QV ++ L + + + +
Sbjct: 1097 NMADGQLHHIMINREEGVVF-IEIDDNRRRQVHLSSGTEFSAVKSLVLGRILEHSDVDQD 1155
Query: 634 KLVASRDGFQGCLASVDLNGRLPDLINDALHRS 666
+A GF GCL++V L+ P + ALH S
Sbjct: 1156 TALAGAQGFTGCLSAVQLSHVAP--LKAALHPS 1186
Score = 50.4 bits (119), Expect = 9e-06
Identities = 43/178 (24%), Positives = 73/178 (41%), Gaps = 22/178 (12%)
Query: 743 DRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVN- 801
D +++ F T DGIL+ + G D + L + + ++ ++ N G + + T VN
Sbjct: 206 DIISLKFKTMQSDGILLHREGPNG--DHITLQLRRARLFLLINSG--EAKLPSTSTLVNL 261
Query: 802 -------DGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGRQLTIFNTQAQIAIGG----- 849
D +H V R G VD H+ + + N +I+ GG
Sbjct: 262 TLGSLLDDQHWHSVLIQRLGKQVNFTVDEH--RHHFHARGEFNLMNLDYEISFGGIPAPG 319
Query: 850 ---KDKGRLFQGQLSGLYYDGLKVLNMAAENNPNIKINGSVRLVGEVPSILGTTQTTS 904
R F G L LYY+G+ ++++A + P I G+V P + T +S
Sbjct: 320 KSVSFPHRNFHGCLENLYYNGVDIIDLAKQQKPQIIAMGNVSFSCSQPQSMPVTFLSS 377
>gi|148664242 cell recognition protein CASPR4 isoform 2 [Homo sapiens]
Length = 1235
Score = 119 bits (299), Expect = 1e-26
Identities = 142/577 (24%), Positives = 233/577 (40%), Gaps = 92/577 (15%)
Query: 501 TFKTKSSYLSLATLQAYTSMHLFFQFKTTSPDGFILFNSGDGNDFIAVELVKG-YIHYVF 559
+F T++SYL T S + F FKTT+ G L N G DFI +EL + + F
Sbjct: 723 SFDTEASYLHFPTFHGELSADVSFFFKTTASSGVFLENLGIA-DFIRIELRSPTVVTFSF 781
Query: 560 DLGNGPNVIKGNSDRPLNDNQWHNVVITRDNSNTHSLKVD---TKVVTQVINGAKNLDLK 616
D+GNGP I S NDNQWH+V + R N SL+VD K +G L L
Sbjct: 782 DVGNGPFEISVQSPTHFNDNQWHHVRVER-NMKEASLQVDQLTPKTQPAPADGHVLLQLN 840
Query: 617 GDLYMAGLAQGMYSNLPKLVASRDGFQGCLASVDLNGRLPDLINDALHRSGQIERGCEGP 676
L++ G A + GF GC+ S+ LNG DL + + +++ GC G
Sbjct: 841 SQLFVGGTA-----------TRQRGFLGCIRSLQLNGMTLDL-EERAQVTPEVQPGCRGH 888
Query: 677 STTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQCNDPGATYIFGKSGGLILYTWPAND 736
++ + C N G C ++ GF CDC+ ++Y+G C++ + Y FG SG ++Y + N
Sbjct: 889 CSSYGK-LCRNGGKCRERPIGFFCDCTFSAYTGPFCSNEISAY-FG-SGSSVIYNFQENY 945
Query: 737 RPSTRSDRLAVGFSTTVKDG-----ILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDI 791
S S A F +K R P L F+ ++ ++ G++ I
Sbjct: 946 LLSKNSSSHAASFHGDMKLSREMIKFSFRTTRTPSLLLFVSSFYKEYLSVIIAKNGSLQI 1005
Query: 792 SIK----EERTPVN-------DGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGRQLTIFN 840
K +E VN DG+ H + R G +++D+ N
Sbjct: 1006 RYKLNKYQEPDVVNFDFKNMADGQLHHIMINREEGVVFIEIDD----------------N 1049
Query: 841 TQAQIAIGGKDKGRLFQGQLSGLYYDGLK--VLNMAAENNPNIKINGSVRLVGE--VPSI 896
+ Q+ + SG + +K VL E++ ++ L G
Sbjct: 1050 RRRQVHLS------------SGTEFSAVKSLVLGRILEHS---DVDQDTALAGAQGFTGC 1094
Query: 897 LGTTQTTSMPPEMSTTVMETTTTMATTTTRKNRSTASIQPTSDDLVSSAECSSDDEDFVE 956
L Q + + P + + + T T S+ QP +D +S E + D
Sbjct: 1095 LSAVQLSHVAP-LKAALHPSHPDPVTVTGHVTESSCMAQPGTD--ATSRERTHSFAD--- 1148
Query: 957 CEPSTANPTEPGIRRVPGASEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEG 1016
T + EP + I+ S+ G ++ +V LCI + +Y+ +
Sbjct: 1149 -HSGTIDDREP-------LANAIKSDSAVIGGLIAVVIFILLCITAIAVRIYQQKR---- 1196
Query: 1017 SYQVDETRNYISNSAQSNGTLMKEKQQSSKSGHKKQK 1053
Y+ E + S + S ++K + + ++ QK
Sbjct: 1197 LYKRSEAKR--SENVDSAEAVLKSELNIQNAVNENQK 1231
Score = 101 bits (252), Expect = 3e-21
Identities = 100/426 (23%), Positives = 173/426 (40%), Gaps = 80/426 (18%)
Query: 306 CEREASILSYDGSMYMKIIMPMVMHTEAEDV-SFRFMSQRAYGLLVATTSRDSADTLRLE 364
C + ++ DG + + +D+ S +F + ++ G+L+ + D + L+
Sbjct: 152 CAYRSEVVDLDGKSSLLYRFDQKSLSPIKDIISLKFKTMQSDGILLHREG-PNGDHITLQ 210
Query: 365 LDGGRVKLMVNLDCIRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTVDDDVA 424
L R+ L++N ++ S+ TL G L+D WH+V + R GK + TVD+
Sbjct: 211 LRRARLFLLINSGEAKLPSTSTLVNLTL--GSLLDDQHWHSVLIQRLGKQVNFTVDEHRH 268
Query: 425 EGTMVGDHTRLEFHNIETGIMTEKRYISVVPSSFIGHLQSLMFNGLLYIDLCKNGDIDYC 484
H R EF+ + ++DY
Sbjct: 269 HF-----HARGEFNLM---------------------------------------NLDY- 283
Query: 485 ELKARFGLRNIIADPVTFKTKSSYLSLATLQAYTSMHLFFQFKTTSPDGFILFNSGDGND 544
E F + PVTF + SYL+L + FQF+T + G +LF+
Sbjct: 284 EGNVSFSCSQPQSMPVTFLSSRSYLALPDFSGEEEVSATFQFRTWNKAGLLLFSE----- 338
Query: 545 FIAVELVKGYIHYVFDLGNGPNVIKGNSDRP------------LNDNQWHNVVITRDNSN 592
++L+ G I G +K N +P LND QWH+V ++ N
Sbjct: 339 ---LQLISGGILLFLSDGK----LKSNLYQPGKLPSDITAGVELNDGQWHSVSLSA-KKN 390
Query: 593 THSLKVDTKVVTQV-INGAKNLDLKGDLYMAGLAQGMYSNLPKLVASRDGFQGCLASVDL 651
S+ VD ++ + + G + + G Y G + + K + GFQGC+ + +
Sbjct: 391 HLSVAVDGQMASAAPLLGPEQIYSGGTYYFGGCPDKSFGS--KCKSPLGGFQGCMRLISI 448
Query: 652 NGRLPDLIN---DALHRSGQIERGCEGPSTTCQEDSCANQGVCMQQWEGFTCDCSMTSYS 708
+G++ DLI+ +L ++ G S C + C + G C Q W F C+C+ T Y
Sbjct: 449 SGKVVDLISVQQGSLGNFSDLQIDSCGISDRCLPNYCEHGGECSQSWSTFHCNCTNTGYR 508
Query: 709 GNQCND 714
G C++
Sbjct: 509 GATCHN 514
Score = 85.1 bits (209), Expect = 3e-16
Identities = 63/249 (25%), Positives = 112/249 (44%), Gaps = 43/249 (17%)
Query: 77 NFETPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFA 136
+F+T +Y+ P ++ + +SF F+TT +G+ L G DF
Sbjct: 723 SFDTEASYLHFPTFHGELSADVSFFFKTTASSGVFLENLGI--------------ADFIR 768
Query: 137 VELLDGNLYLL-LDMGSGTIKVKA-TQKKANDGEWYHVDIQRDGRSGTISVNSRRTPFTA 194
+EL + D+G+G ++ + ND +W+HV ++R+ + ++ V+ + TP T
Sbjct: 769 IELRSPTVVTFSFDVGNGPFEISVQSPTHFNDNQWHHVRVERNMKEASLQVD-QLTPKTQ 827
Query: 195 SGESE---ILDLEGDMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIR 251
++ +L L +++GG TA G++GCIR L ++G + ++
Sbjct: 828 PAPADGHVLLQLNSQLFVGG---------------TATRQRGFLGCIRSLQLNGMTLDLE 872
Query: 252 QLAEMQNAAGVKSSCSRMSAKQCDSYP--CKNNAVCKDGWNRFICDCTGTGYWGRTCERE 309
+ A++ V+ C C SY C+N C++ F CDCT + Y G C E
Sbjct: 873 ERAQV--TPEVQPGCRG----HCSSYGKLCRNGGKCRERPIGFFCDCTFSAYTGPFCSNE 926
Query: 310 ASILSYDGS 318
S GS
Sbjct: 927 ISAYFGSGS 935
Score = 80.1 bits (196), Expect = 1e-14
Identities = 61/257 (23%), Positives = 108/257 (42%), Gaps = 40/257 (15%)
Query: 61 GEVVFKCENVATLDPINFETPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQE 120
G V F C ++ P+ F + +Y++LP ++ + S +F FRT GL+LF+
Sbjct: 285 GNVSFSCSQPQSM-PVTFLSSRSYLALPDFSGEEEVSATFQFRTWNKAGLLLFSE----- 338
Query: 121 RKDARSQKNTKVDFFAVELLDGNLYLLLDMGSGTIKVKATQK---------KANDGEWYH 171
++L+ G + L L G + K + NDG+W+
Sbjct: 339 ----------------LQLISGGILLFLSDGKLKSNLYQPGKLPSDITAGVELNDGQWHS 382
Query: 172 VDIQRDGRSGTISVNSRRTPFTASGESEILDLEGDMYLGGLPENRAGLILPTELWTAMLN 231
V + +++V+ + E + G Y GG P+ G + L
Sbjct: 383 VSLSAKKNHLSVAVDGQMASAAPLLGPEQIYSGGTYYFGGCPDKSFGSKCKSPLG----- 437
Query: 232 YGYVGCIRDLFIDGRSKNIR--QLAEMQNAAGVKSSCSRMSAKQCDSYPCKNNAVCKDGW 289
G+ GC+R + I G+ ++ Q + N + ++ +S + +Y C++ C W
Sbjct: 438 -GFQGCMRLISISGKVVDLISVQQGSLGNFSDLQIDSCGISDRCLPNY-CEHGGECSQSW 495
Query: 290 NRFICDCTGTGYWGRTC 306
+ F C+CT TGY G TC
Sbjct: 496 STFHCNCTNTGYRGATC 512
Score = 57.0 bits (136), Expect = 9e-08
Identities = 90/393 (22%), Positives = 151/393 (38%), Gaps = 83/393 (21%)
Query: 335 DVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLDCIRINCNSSKGPE--TL 392
DVSF F + + G+ + AD +R+EL V + + + GP ++
Sbjct: 743 DVSFFFKTTASSGVFLENLG--IADFIRIELRSPTV--------VTFSFDVGNGPFEISV 792
Query: 393 YAGQKLNDNEWHTVRVVRRGKSLKLTVDD--DVAEGTMVGDHTRLEFHN--IETGIMTEK 448
+ NDN+WH VRV R K L VD + H L+ ++ G T +
Sbjct: 793 QSPTHFNDNQWHHVRVERNMKEASLQVDQLTPKTQPAPADGHVLLQLNSQLFVGGTATRQ 852
Query: 449 RYISVVPSSFIGHLQSLMFNGLL-----------------------YIDLCKNGDI---- 481
R F+G ++SL NG+ Y LC+NG
Sbjct: 853 R-------GFLGCIRSLQLNGMTLDLEERAQVTPEVQPGCRGHCSSYGKLCRNGGKCRER 905
Query: 482 ---------------DYC--ELKARFG-----LRNIIADPVTFKTKSSYLSLATLQAYTS 519
+C E+ A FG + N + + K SS+ + S
Sbjct: 906 PIGFFCDCTFSAYTGPFCSNEISAYFGSGSSVIYNFQENYLLSKNSSSHAASFHGDMKLS 965
Query: 520 MHLF-FQFKTTSPDGFILFNSGDGNDFIAVELVKG---YIHYVFDLGNGPNVIKGNSD-R 574
+ F F+TT +LF S ++++V + K I Y + P+V+ N D +
Sbjct: 966 REMIKFSFRTTRTPSLLLFVSSFYKEYLSVIIAKNGSLQIRYKLNKYQEPDVV--NFDFK 1023
Query: 575 PLNDNQWHNVVITRDNSNTHSLKVDTKVVTQV-INGAKNLDLKGDLYMAGLAQGMYSNLP 633
+ D Q H+++I R+ +++D QV ++ L + + + +
Sbjct: 1024 NMADGQLHHIMINREEGVVF-IEIDDNRRRQVHLSSGTEFSAVKSLVLGRILEHSDVDQD 1082
Query: 634 KLVASRDGFQGCLASVDLNGRLPDLINDALHRS 666
+A GF GCL++V L+ P + ALH S
Sbjct: 1083 TALAGAQGFTGCLSAVQLSHVAP--LKAALHPS 1113
Score = 40.0 bits (92), Expect = 0.012
Identities = 31/115 (26%), Positives = 51/115 (44%), Gaps = 23/115 (20%)
Query: 98 ISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFAVELLDGNLYLLLDMGSGTIKV 157
IS F+T + +G++L G D ++L L+LL++ SG K+
Sbjct: 183 ISLKFKTMQSDGILLHREGP-------------NGDHITLQLRRARLFLLIN--SGEAKL 227
Query: 158 KATQKKAN--------DGEWYHVDIQRDGRSGTISVNSRRTPFTASGESEILDLE 204
+T N D W+ V IQR G+ +V+ R F A GE +++L+
Sbjct: 228 PSTSTLVNLTLGSLLDDQHWHSVLIQRLGKQVNFTVDEHRHHFHARGEFNLMNLD 282
Score = 34.3 bits (77), Expect = 0.64
Identities = 30/119 (25%), Positives = 51/119 (42%), Gaps = 21/119 (17%)
Query: 487 KARFGLRNII------ADPVTFKTKSSYL------SLATLQAYTSMHLFFQFKTTSPDGF 534
K R G+R + ++ V KSS L SL+ ++ S+ +FKT DG
Sbjct: 140 KGRIGMRIEVFGCAYRSEVVDLDGKSSLLYRFDQKSLSPIKDIISL----KFKTMQSDGI 195
Query: 535 ILFNSGDGNDFIAVELVKGYIHYVFDLGNG-----PNVIKGNSDRPLNDNQWHNVVITR 588
+L G D I ++L + + + + G ++ L+D WH+V+I R
Sbjct: 196 LLHREGPNGDHITLQLRRARLFLLINSGEAKLPSTSTLVNLTLGSLLDDQHWHSVLIQR 254
>gi|18640734 contactin associated protein-like 5 [Homo sapiens]
Length = 1306
Score = 117 bits (293), Expect = 6e-26
Identities = 109/421 (25%), Positives = 179/421 (42%), Gaps = 22/421 (5%)
Query: 306 CEREASILSYDG-SMYMKIIMPMVMHTEAEDVSFRFMSQRAYGLLVATTSRDSADTLRLE 364
C ++ + +DG S + +M T + +S +F S + G+L + D + LE
Sbjct: 174 CSYKSDVADFDGRSSLLYRFNQKLMSTLKDVISLKFKSMQGDGVLFHGEGQ-RGDHITLE 232
Query: 365 LDGGRVKLMVNLDCIRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTVDDDVA 424
L GR+ L +NL + +SS TL G L+D WH+V + R GK + TVD
Sbjct: 233 LQKGRLALHLNLGDSKARLSSSLPSATL--GSLLDDQHWHSVLIERVGKQVNFTVDKHTQ 290
Query: 425 EGTMVG--DHTRLEFHNIETGIMTEKRYISVVPSSFIGHLQSLMFNGLLYIDLCKNGDID 482
G D +++ GI + + + +F G +++L +NG+ IDL K
Sbjct: 291 HFRTKGETDALDIDYELSFGGIPVPGKPGTFLKKNFHGCIENLYYNGVNIIDLAKRRKHQ 350
Query: 483 YCELKARFGLRNIIADPVTFKTKS-SYLSLATLQAYTSMHLFFQFKTTSPDGFILFNS-G 540
F P+TF S SYL L + + FQF+T + DG +L
Sbjct: 351 IYTGNVTFSCSEPQIVPITFVNSSGSYLLLPGTPQIDGLSVSFQFRTWNKDGLLLSTELS 410
Query: 541 DGNDFIAVELVKGYIHYVFD--LGNGPNVIKGNSDRPLNDNQWHNVVITRDNSNTHSLKV 598
+G+ + + L G + V ++ G++ LND WH+V I N +L +
Sbjct: 411 EGSGTLLLSLEGGILRLVIQKMTERVAEILTGSN---LNDGLWHSVSINA-RRNRITLTL 466
Query: 599 DTKVVTQVINGAKNLDLKGDLYMAGLAQGMYSNLP--KLVASRDGFQGCLASVDLNGRLP 656
D + + G+ Y G G NL + + FQGC+ + ++ +
Sbjct: 467 DDEAAPPAPDSTWVQIYSGNSYYFG---GCPDNLTDSQCLNPIKAFQGCMRLIFIDNQPK 523
Query: 657 DLIN---DALHRSGQIERGCEGPSTTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQCN 713
DLI+ +L + C + C + G C Q W F C+CS TSY+G C+
Sbjct: 524 DLISVQQGSLGNFSDLHIDLCSIKDRCLPNYCEHGGSCSQSWTTFYCNCSDTSYTGATCH 583
Query: 714 D 714
+
Sbjct: 584 N 584
Score = 109 bits (273), Expect = 1e-23
Identities = 109/406 (26%), Positives = 178/406 (43%), Gaps = 50/406 (12%)
Query: 500 VTFKTKSSYLSLATLQAYTSMHLFFQFKTTSPDGFILFNSGDGNDFIAVELVK-GYIHYV 558
V+F T++SYL T A S + F FKTT+ G L N G DFI +E+ I +
Sbjct: 793 VSFYTEASYLHFPTFHAEFSADISFFFKTTALSGVFLENLGI-KDFIRLEISSPSEITFA 851
Query: 559 FDLGNGPNVIKGNSDRPLNDNQWHNVVITRDNSNTHSLKVD-----TKVVTQVINGAKNL 613
D+GNGP + S LNDNQWH V R+ T SL+VD T+ ++ G L
Sbjct: 852 IDVGNGPVELVVQSPSLLNDNQWHYVRAERNLKET-SLQVDNLPRSTRETSE--EGHFRL 908
Query: 614 DLKGDLYMAGLAQGMYSNLPKLVASRDGFQGCLASVDLNGRLPDLINDALHRSGQIERGC 673
L L++ G + + + GF GC+ S+ LNG+ DL A SG + GC
Sbjct: 909 QLNSQLFVGGTS-----------SRQKGFLGCIRSLHLNGQKMDLEERAKVTSG-VRPGC 956
Query: 674 EGPSTTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQCN---------DPGATYIFGK- 723
G ++ C N G C+++ G+ CDC+ + Y G C TY+F +
Sbjct: 957 PGHCSS-YGSICHNGGKCVEKHNGYLCDCTNSPYEGPFCKKEVSAVFEAGTSVTYMFQEP 1015
Query: 724 ---SGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDF-LQLHIEQGK 779
+ + L + + + +A+ F TT +L+ I+S+ DF + L + G
Sbjct: 1016 YPVTKNISLSSSAIYTDSAPSKENIALSFVTTQAPSLLLFINSSS--QDFVVVLLCKNGS 1073
Query: 780 IGVVFNIGTVDISI-KEERTPVNDGKYHVVRFTRNGGNATLQVD-------NWPVNEHYP 831
+ V +++ + + + + + H ++ R G T+Q+D N+ +
Sbjct: 1074 LQVRYHLNKEETHVFTIDADNFANRRMHHLKINREGRELTIQMDQQLRLSYNFSPEVEFR 1133
Query: 832 TGRQLTIFNTQAQIAIG---GKDKGRLFQGQLSGLYYDGLKVLNMA 874
R LT+ + + K F G +S + Y+ + L A
Sbjct: 1134 VIRSLTLGKVTENLGLDSEVAKANAMGFAGCMSSVQYNHIAPLKAA 1179
Score = 89.4 bits (220), Expect = 2e-17
Identities = 79/370 (21%), Positives = 161/370 (43%), Gaps = 64/370 (17%)
Query: 76 INFETPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFF 135
++F T +Y+ P ++ + ISF F+TT +G+ L G DF
Sbjct: 793 VSFYTEASYLHFPTFHAEFSADISFFFKTTALSGVFLENLGIK--------------DFI 838
Query: 136 AVELLD-GNLYLLLDMGSGTIK-VKATQKKANDGEWYHVDIQRDGRSGTISVNS--RRTP 191
+E+ + +D+G+G ++ V + ND +W++V +R+ + ++ V++ R T
Sbjct: 839 RLEISSPSEITFAIDVGNGPVELVVQSPSLLNDNQWHYVRAERNLKETSLQVDNLPRSTR 898
Query: 192 FTASGESEILDLEGDMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIR 251
T+ L L +++GG T+ G++GCIR L ++G+ ++
Sbjct: 899 ETSEEGHFRLQLNSQLFVGG---------------TSSRQKGFLGCIRSLHLNGQKMDLE 943
Query: 252 QLAEMQNAAGVKSSCSRMSAKQCDSYP--CKNNAVCKDGWNRFICDCTGTGYWGRTCERE 309
+ A++ +GV+ C C SY C N C + N ++CDCT + Y G C++E
Sbjct: 944 ERAKV--TSGVRPGCPG----HCSSYGSICHNGGKCVEKHNGYLCDCTNSPYEGPFCKKE 997
Query: 310 ASILSYDGS----MYMK--------IIMPMVMHTEA----EDVSFRFMSQRAYGLLVATT 353
S + G+ M+ + + ++T++ E+++ F++ +A LL+
Sbjct: 998 VSAVFEAGTSVTYMFQEPYPVTKNISLSSSAIYTDSAPSKENIALSFVTTQAPSLLLFIN 1057
Query: 354 SRDSADTLRLELDGGRVKLMVNLDCIRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGK 413
S + L G ++ +R + N + + H +++ R G+
Sbjct: 1058 SSSQDFVVVLLCKNGSLQ-------VRYHLNKEETHVFTIDADNFANRRMHHLKINREGR 1110
Query: 414 SLKLTVDDDV 423
L + +D +
Sbjct: 1111 ELTIQMDQQL 1120
Score = 84.7 bits (208), Expect = 4e-16
Identities = 83/352 (23%), Positives = 148/352 (42%), Gaps = 84/352 (23%)
Query: 87 LPKWNTKRMGS----ISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFAVELLDG 142
L ++N K M + IS F++ + +G++ HG+ Q + D +EL G
Sbjct: 190 LYRFNQKLMSTLKDVISLKFKSMQGDGVLF--HGEGQ-----------RGDHITLELQKG 236
Query: 143 NLYLLLDMGSGTIKVKATQKKA------NDGEWYHVDIQRDGRSGTISVNSRRTPFTASG 196
L L L++G ++ ++ A +D W+ V I+R G+ +V+ F G
Sbjct: 237 RLALHLNLGDSKARLSSSLPSATLGSLLDDQHWHSVLIERVGKQVNFTVDKHTQHFRTKG 296
Query: 197 ESEILDLEGDMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEM 256
E++ LD++ ++ GG+P +P + T L + GCI +L+ +G NI LA+
Sbjct: 297 ETDALDIDYELSFGGIP-------VPGKPGT-FLKKNFHGCIENLYYNG--VNIIDLAKR 346
Query: 257 QN----AAGVKSSCSRMSAKQCDSYPCKNNAVCKDGWNRFICDCTGTGYWGRTCEREASI 312
+ V SCS E +
Sbjct: 347 RKHQIYTGNVTFSCS---------------------------------------EPQIVP 367
Query: 313 LSYDGSMYMKIIMPMVMHTEAEDVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKL 372
+++ S +++P + VSF+F + GLL++T + + TL L L+GG ++L
Sbjct: 368 ITFVNSSGSYLLLPGTPQIDGLSVSFQFRTWNKDGLLLSTELSEGSGTLLLSLEGGILRL 427
Query: 373 MVNLDCIRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTVDDDVA 424
++ R+ + G LND WH+V + R + LT+DD+ A
Sbjct: 428 VIQKMTERV--------AEILTGSNLNDGLWHSVSINARRNRITLTLDDEAA 471
Score = 83.2 bits (204), Expect = 1e-15
Identities = 81/313 (25%), Positives = 131/313 (41%), Gaps = 57/313 (18%)
Query: 11 GGSPSTADLPGSPVSNNFMGCLKEVVYKNNDIRLELSRLARIADTKMKIY-GEVVFKCEN 69
GG P PG+ + NF GC++ + Y +I ++L++ K +IY G V F C
Sbjct: 310 GGIPVPGK-PGTFLKKNFHGCIENLYYNGVNI-IDLAKRR-----KHQIYTGNVTFSCSE 362
Query: 70 VATLDPINF-ETPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKDARSQK 128
+ PI F + +Y+ LP S+SF FRT +GL+L T
Sbjct: 363 PQIV-PITFVNSSGSYLLLPGTPQIDGLSVSFQFRTWNKDGLLLST-------------- 407
Query: 129 NTKVDFFAVELLDGNLYLLLDMGSGTIKV---KATQKKA--------NDGEWYHVDIQRD 177
EL +G+ LLL + G +++ K T++ A NDG W+ V I
Sbjct: 408 ---------ELSEGSGTLLLSLEGGILRLVIQKMTERVAEILTGSNLNDGLWHSVSINAR 458
Query: 178 GRSGTISVNSRRTPFTASGESEILDLEGDMYLGGLPENRAGLILPTELWTAMLN--YGYV 235
T++++ P + Y GG P+N + LN +
Sbjct: 459 RNRITLTLDDEAAPPAPDSTWVQIYSGNSYYFGGCPDNLTD--------SQCLNPIKAFQ 510
Query: 236 GCIRDLFIDGRSKNIR--QLAEMQNAAGVKSSCSRMSAKQCDSYPCKNNAVCKDGWNRFI 293
GC+R +FID + K++ Q + N + + + + +Y C++ C W F
Sbjct: 511 GCMRLIFIDNQPKDLISVQQGSLGNFSDLHIDLCSIKDRCLPNY-CEHGGSCSQSWTTFY 569
Query: 294 CDCTGTGYWGRTC 306
C+C+ T Y G TC
Sbjct: 570 CNCSDTSYTGATC 582
Score = 42.7 bits (99), Expect = 0.002
Identities = 38/180 (21%), Positives = 73/180 (40%), Gaps = 19/180 (10%)
Query: 739 STRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERT 798
ST D +++ F + DG+L + G D + L +++G++ + N+G +
Sbjct: 199 STLKDVISLKFKSMQGDGVLFHGEGQRG--DHITLELQKGRLALHLNLGDSKARLSSSLP 256
Query: 799 P------VNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGRQLTIFNTQAQIAIGGKDK 852
++D +H V R G VD +H+ T + + +++ GG
Sbjct: 257 SATLGSLLDDQHWHSVLIERVGKQVNFTVDKH--TQHFRTKGETDALDIDYELSFGGIPV 314
Query: 853 G--------RLFQGQLSGLYYDGLKVLNMAAENNPNIKINGSVRLVGEVPSILGTTQTTS 904
+ F G + LYY+G+ ++++A I G+V P I+ T S
Sbjct: 315 PGKPGTFLKKNFHGCIENLYYNGVNIIDLAKRRKHQI-YTGNVTFSCSEPQIVPITFVNS 373
Score = 40.0 bits (92), Expect = 0.012
Identities = 88/397 (22%), Positives = 134/397 (33%), Gaps = 99/397 (24%)
Query: 330 HTE-AEDVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLDCIRINCNSSKG 388
H E + D+SF F + G+ + D +RLE+ I + G
Sbjct: 808 HAEFSADISFFFKTTALSGVFLENLG--IKDFIRLEISSPSE--------ITFAIDVGNG 857
Query: 389 PETLYAGQK--LNDNEWHTVRVVRRGKSLKLTVDD--DVAEGTMVGDHTRLEFHNIETGI 444
P L LNDN+WH VR R K L VD+ T H RL+ ++
Sbjct: 858 PVELVVQSPSLLNDNQWHYVRAERNLKETSLQVDNLPRSTRETSEEGHFRLQLNSQLFVG 917
Query: 445 MTEKRYISVVPSSFIGHLQSLMFNGLL-----------------------YIDLCKNG-- 479
T R F+G ++SL NG Y +C NG
Sbjct: 918 GTSSRQ-----KGFLGCIRSLHLNGQKMDLEERAKVTSGVRPGCPGHCSSYGSICHNGGK 972
Query: 480 ----------DIDYCELKARFGLRNIIA-----DPVTFKTKSSY-----LSLATLQAYTS 519
D + F + + A VT+ + Y +SL++ YT
Sbjct: 973 CVEKHNGYLCDCTNSPYEGPFCKKEVSAVFEAGTSVTYMFQEPYPVTKNISLSSSAIYTD 1032
Query: 520 M-----HLFFQFKTTSPDGFILFNSGDGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSDR 574
++ F TT +LF + DF+ V L K NG ++ +
Sbjct: 1033 SAPSKENIALSFVTTQAPSLLLFINSSSQDFVVVLLCK----------NGSLQVRYH--- 1079
Query: 575 PLNDNQWHNVVITRD---NSNTHSLKVDTKVVTQVINGAKNLDLK------------GDL 619
LN + H I D N H LK++ + I + L L L
Sbjct: 1080 -LNKEETHVFTIDADNFANRRMHHLKINREGRELTIQMDQQLRLSYNFSPEVEFRVIRSL 1138
Query: 620 YMAGLAQGMYSNLPKLVASRDGFQGCLASVDLNGRLP 656
+ + + + + A+ GF GC++SV N P
Sbjct: 1139 TLGKVTENLGLDSEVAKANAMGFAGCMSSVQYNHIAP 1175
>gi|239743756 PREDICTED: hypothetical protein LOC389722 isoform 2
[Homo sapiens]
Length = 1207
Score = 117 bits (292), Expect = 8e-26
Identities = 109/418 (26%), Positives = 179/418 (42%), Gaps = 20/418 (4%)
Query: 306 CEREASILSYDGSMYMKIIMPMVMHTEAEDV-SFRFMSQRAYGLLVATTSRDSADTLRLE 364
C ++ ++ +DG + + DV S +F + ++ G+L+ + + + LE
Sbjct: 177 CAYKSEVVYFDGQSALLYTLDKKPLKPIRDVISLKFKAMQSNGILLHREGQHG-NHITLE 235
Query: 365 LDGGRVKLMVNLDCIRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTVDDDVA 424
L G++ +N ++ S+ P TL G L+D WH+V + + TVD
Sbjct: 236 LIKGKLVFFLNSGNAKLP--STIAPVTLTLGSLLDDQHWHSVLIELLDTQVNFTVDKHTH 293
Query: 425 EGTMVGDHTRLEFHNIET---GIMTEKRYISVVPSSFIGHLQSLMFNGLLYIDLCKNGDI 481
GD + L+ N E GI++ R + SF G L++L +NG+ +L K
Sbjct: 294 HFQAKGDSSNLDL-NFEISFGGILSPGRSRAFTRKSFHGCLENLYYNGVDVTELAKKHKP 352
Query: 482 DYCEL-KARFGLRNIIADPVTFKTKSSYLSLATLQAYTSMHLFFQFKTTSPDGFILFNSG 540
+ F PVTF + SYL+L + + FQF+T + G +LF
Sbjct: 353 QILMMGNVSFSCPQPQTVPVTFLSSRSYLALPGNSGEDKVSVTFQFRTWNRAGHLLFGEL 412
Query: 541 D-GNDFIAVELVKGYIHY-VFDLGNGPNVIKGNSDRPLNDNQWHNVVITRDNSNTHSLKV 598
G+ + L G + +F G P + + LND QWH+V + S+ + +
Sbjct: 413 QRGSGSFVLFLKDGKLKLSLFQAGQSPRNVTAGAG--LNDGQWHSVSFSAKWSHMNVVVD 470
Query: 599 DTKVVTQVINGAKNLDLKGDLYMAGLAQGMYSNLPKLVASRDGFQGCLASVDLNGRLPDL 658
D V ++ A +D GD Y G G S + GFQGCL + + + D
Sbjct: 471 DDTAVQPLV--AVLID-SGDTYYFGGCLGNSSG-SGCKSPLGGFQGCLRLITIGDKAVDP 526
Query: 659 I---NDALHRSGQIERGCEGPSTTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQCN 713
I AL ++ G + C C + G C Q W+ F+CDC T Y+G C+
Sbjct: 527 ILVQQGALGSFRDLQIDSCGITDRCLPSYCEHGGECSQSWDTFSCDCLGTGYTGETCH 584
Score = 84.3 bits (207), Expect = 5e-16
Identities = 75/286 (26%), Positives = 121/286 (42%), Gaps = 36/286 (12%)
Query: 27 NFMGCLKEVVYKNNDIRLELSRLARIADTKMKIYGEVVFKCENVATLDPINFETPEAYIS 86
+F GCL+ + Y D+ + LA+ ++ + G V F C T+ P+ F + +Y++
Sbjct: 328 SFHGCLENLYYNGVDV----TELAKKHKPQILMMGNVSFSCPQPQTV-PVTFLSSRSYLA 382
Query: 87 LPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFAVELLDGNLYL 146
LP + + S++F FRT G +LF G+ Q + F + L DG L L
Sbjct: 383 LPGNSGEDKVSVTFQFRTWNRAGHLLF--GELQRGSGS----------FVLFLKDGKLKL 430
Query: 147 LLDMGSGTIKVKATQKKANDGEWYHVDIQRDGRSGTISVNSRRT--PFTASGESEILDLE 204
L + + NDG+W+ V + V+ P A ++D
Sbjct: 431 SLFQAGQSPRNVTAGAGLNDGQWHSVSFSAKWSHMNVVVDDDTAVQPLVAV----LIDSG 486
Query: 205 GDMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEMQNAAG--- 261
Y GG N +G + L G+ GC+R + I K + + Q A G
Sbjct: 487 DTYYFGGCLGNSSGSGCKSPLG------GFQGCLRLITIG--DKAVDPILVQQGALGSFR 538
Query: 262 -VKSSCSRMSAKQCDSYPCKNNAVCKDGWNRFICDCTGTGYWGRTC 306
++ ++ + SY C++ C W+ F CDC GTGY G TC
Sbjct: 539 DLQIDSCGITDRCLPSY-CEHGGECSQSWDTFSCDCLGTGYTGETC 583
Score = 63.2 bits (152), Expect = 1e-09
Identities = 44/125 (35%), Positives = 61/125 (48%), Gaps = 6/125 (4%)
Query: 501 TFKTKSSYLSLATLQAYTSMHLFFQFKTTSPDGFILFNSGDGNDFIAVEL-VKGYIHYVF 559
+F T++SYL + + F FKTT G + N G DFI +EL + + F
Sbjct: 795 SFNTETSYLHFPAFHGELTADVCFFFKTTVSSGVFMENLGI-TDFIRIELRAPTEVTFSF 853
Query: 560 DLGNGPNVIKGNSDRPLNDNQWHNVVITRDNSNTHSLKVD---TKVVTQVINGAKNLDLK 616
D+GNGP + S P NDNQWH+V R N SL+VD K+ +G L L
Sbjct: 854 DVGNGPCEVTVQSPTPFNDNQWHHVRAER-NVKGASLQVDQLPQKMQPAPADGHVRLQLN 912
Query: 617 GDLYM 621
L++
Sbjct: 913 SQLFI 917
Score = 52.4 bits (124), Expect = 2e-06
Identities = 71/340 (20%), Positives = 123/340 (36%), Gaps = 76/340 (22%)
Query: 98 ISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFAVELLDGNLYLLLDMGSGTIKV 157
IS F+ + NG++L G+ +EL+ G L L+ SG K+
Sbjct: 208 ISLKFKAMQSNGILLHREGQHGNH-------------ITLELIKGKLVFFLN--SGNAKL 252
Query: 158 KATQKKA--------NDGEWYHVDIQRDGRSGTISVNSRRTPFTASGESEILDLEGDMYL 209
+T +D W+ V I+ +V+ F A G+S LDL ++
Sbjct: 253 PSTIAPVTLTLGSLLDDQHWHSVLIELLDTQVNFTVDKHTHHFQAKGDSSNLDLNFEISF 312
Query: 210 GGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEMQNAAGVKSSCSRM 269
GG IL A + GC+ +L+ +G ++ +LA+ +
Sbjct: 313 GG--------ILSPGRSRAFTRKSFHGCLENLYYNG--VDVTELAKKHKPQILMMGNVSF 362
Query: 270 SAKQCDSYPCKNNAVCKDGWNRFICDCTGTGYWGRTCEREASILSYDGSMYMKIIMPMVM 329
S Q + P F+ + G + E + S
Sbjct: 363 SCPQPQTVPV-----------TFLSSRSYLALPGNSGEDKVS------------------ 393
Query: 330 HTEAEDVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLDCIRINCNSSKGP 389
V+F+F + G L+ + + + L L G++KL + + + P
Sbjct: 394 ------VTFQFRTWNRAGHLLFGELQRGSGSFVLFLKDGKLKLSL--------FQAGQSP 439
Query: 390 ETLYAGQKLNDNEWHTVRVVRRGKSLKLTVDDDVAEGTMV 429
+ AG LND +WH+V + + + VDDD A +V
Sbjct: 440 RNVTAGAGLNDGQWHSVSFSAKWSHMNVVVDDDTAVQPLV 479
Score = 41.6 bits (96), Expect = 0.004
Identities = 75/309 (24%), Positives = 113/309 (36%), Gaps = 68/309 (22%)
Query: 391 TLYAGQKLNDNEWHTVRVVRRGKSLKLTVDDDVAEGTMVGDHTRLEFHNIETGIMTEKRY 450
T+ + NDN+WH VR R K L VD + +K
Sbjct: 863 TVQSPTPFNDNQWHHVRAERNVKGASLQVDQ-----------------------LPQK-- 897
Query: 451 ISVVPSSFIGHLQSLMFNGLLYIDLCKNGDIDYCELKARFGLRNIIA----DPVTFKTKS 506
+ P+ GH++ L N L+I E+ A F + + + T S
Sbjct: 898 --MQPAPADGHVR-LQLNSQLFI-----------EISAYFATGSSMTYHFQEHYTLSENS 943
Query: 507 SYL--SLATLQAYTSMHLFFQFKTTSPDGFILFNSGDGNDFIAVELVKG---YIHYVFDL 561
S L SL T + F+TT +L+ S ++++V L I Y D
Sbjct: 944 SSLVSSLYRDVTLTREMITLSFRTTRSPSLLLYVSSFYEEYLSVILANNGSLQIRYKLDR 1003
Query: 562 GNGPNVIKGNSDRPLNDNQWHNVVITRDNSNTHSLKVDTKVVTQVI-------NGAKNLD 614
P+ + + + D Q H V I R+ + ++V+ QVI N K+L
Sbjct: 1004 HQNPDAFTFDF-KNMADGQLHQVKINREEAVV-MVEVNQSAKKQVILSSGTEFNAVKSLI 1061
Query: 615 LKGDLYMAGLAQGMYSNLPKLVASRDGFQGCLASVDLNGRLPDLINDALHRSGQIE---R 671
L L AG ++ A+ GF GCL++V P + AL SG R
Sbjct: 1062 LGKVLEAAG------ADPDTRRAATSGFTGCLSAVRFGRAAP--LKAALRPSGPSRVTVR 1113
Query: 672 GCEGPSTTC 680
G P C
Sbjct: 1114 GHVAPMARC 1122
Score = 40.4 bits (93), Expect = 0.009
Identities = 25/79 (31%), Positives = 41/79 (51%), Gaps = 5/79 (6%)
Query: 749 FSTTVKDGILVRIDSAPGLGDFLQLHIEQG-KIGVVFNIGTVDISIK-EERTPVNDGKYH 806
F TTV G+ + G+ DF+++ + ++ F++G + + TP ND ++H
Sbjct: 820 FKTTVSSGVFME---NLGITDFIRIELRAPTEVTFSFDVGNGPCEVTVQSPTPFNDNQWH 876
Query: 807 VVRFTRNGGNATLQVDNWP 825
VR RN A+LQVD P
Sbjct: 877 HVRAERNVKGASLQVDQLP 895
Score = 38.1 bits (87), Expect = 0.044
Identities = 30/138 (21%), Positives = 59/138 (42%), Gaps = 20/138 (14%)
Query: 77 NFETPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFA 136
+F T +Y+ P ++ + + F F+TT +G+ + G DF
Sbjct: 795 SFNTETSYLHFPAFHGELTADVCFFFKTTVSSGVFMENLG--------------ITDFIR 840
Query: 137 VEL-LDGNLYLLLDMGSGTIKVKA-TQKKANDGEWYHVDIQRDGRSGTISVN---SRRTP 191
+EL + D+G+G +V + ND +W+HV +R+ + ++ V+ + P
Sbjct: 841 IELRAPTEVTFSFDVGNGPCEVTVQSPTPFNDNQWHHVRAERNVKGASLQVDQLPQKMQP 900
Query: 192 FTASGESEILDLEGDMYL 209
A G L L +++
Sbjct: 901 APADGHVR-LQLNSQLFI 917
Score = 35.4 bits (80), Expect = 0.29
Identities = 47/202 (23%), Positives = 80/202 (39%), Gaps = 25/202 (12%)
Query: 719 YIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQG 778
Y G+S +LYT R D +++ F +GIL+ + G + + L + +G
Sbjct: 185 YFDGQSA--LLYTLDKKPLKPIR-DVISLKFKAMQSNGILLHREGQHG--NHITLELIKG 239
Query: 779 KIGVVFNIGTVDISIKEERTPV--------NDGKYHVVRFTRNGGNATLQVDNWPVNEHY 830
K+ VF + + + + PV +D +H V VD H+
Sbjct: 240 KL--VFFLNSGNAKLPSTIAPVTLTLGSLLDDQHWHSVLIELLDTQVNFTVDKH--THHF 295
Query: 831 PTGRQLTIFNTQAQIAIGG-KDKGRL-------FQGQLSGLYYDGLKVLNMAAENNPNIK 882
+ + +I+ GG GR F G L LYY+G+ V +A ++ P I
Sbjct: 296 QAKGDSSNLDLNFEISFGGILSPGRSRAFTRKSFHGCLENLYYNGVDVTELAKKHKPQIL 355
Query: 883 INGSVRLVGEVPSILGTTQTTS 904
+ G+V P + T +S
Sbjct: 356 MMGNVSFSCPQPQTVPVTFLSS 377
>gi|239743754 PREDICTED: hypothetical protein LOC389722 isoform 1
[Homo sapiens]
Length = 1288
Score = 117 bits (292), Expect = 8e-26
Identities = 109/418 (26%), Positives = 179/418 (42%), Gaps = 20/418 (4%)
Query: 306 CEREASILSYDGSMYMKIIMPMVMHTEAEDV-SFRFMSQRAYGLLVATTSRDSADTLRLE 364
C ++ ++ +DG + + DV S +F + ++ G+L+ + + + LE
Sbjct: 177 CAYKSEVVYFDGQSALLYTLDKKPLKPIRDVISLKFKAMQSNGILLHREGQHG-NHITLE 235
Query: 365 LDGGRVKLMVNLDCIRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTVDDDVA 424
L G++ +N ++ S+ P TL G L+D WH+V + + TVD
Sbjct: 236 LIKGKLVFFLNSGNAKLP--STIAPVTLTLGSLLDDQHWHSVLIELLDTQVNFTVDKHTH 293
Query: 425 EGTMVGDHTRLEFHNIET---GIMTEKRYISVVPSSFIGHLQSLMFNGLLYIDLCKNGDI 481
GD + L+ N E GI++ R + SF G L++L +NG+ +L K
Sbjct: 294 HFQAKGDSSNLDL-NFEISFGGILSPGRSRAFTRKSFHGCLENLYYNGVDVTELAKKHKP 352
Query: 482 DYCEL-KARFGLRNIIADPVTFKTKSSYLSLATLQAYTSMHLFFQFKTTSPDGFILFNSG 540
+ F PVTF + SYL+L + + FQF+T + G +LF
Sbjct: 353 QILMMGNVSFSCPQPQTVPVTFLSSRSYLALPGNSGEDKVSVTFQFRTWNRAGHLLFGEL 412
Query: 541 D-GNDFIAVELVKGYIHY-VFDLGNGPNVIKGNSDRPLNDNQWHNVVITRDNSNTHSLKV 598
G+ + L G + +F G P + + LND QWH+V + S+ + +
Sbjct: 413 QRGSGSFVLFLKDGKLKLSLFQAGQSPRNVTAGAG--LNDGQWHSVSFSAKWSHMNVVVD 470
Query: 599 DTKVVTQVINGAKNLDLKGDLYMAGLAQGMYSNLPKLVASRDGFQGCLASVDLNGRLPDL 658
D V ++ A +D GD Y G G S + GFQGCL + + + D
Sbjct: 471 DDTAVQPLV--AVLID-SGDTYYFGGCLGNSSG-SGCKSPLGGFQGCLRLITIGDKAVDP 526
Query: 659 I---NDALHRSGQIERGCEGPSTTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQCN 713
I AL ++ G + C C + G C Q W+ F+CDC T Y+G C+
Sbjct: 527 ILVQQGALGSFRDLQIDSCGITDRCLPSYCEHGGECSQSWDTFSCDCLGTGYTGETCH 584
Score = 110 bits (276), Expect = 5e-24
Identities = 99/345 (28%), Positives = 150/345 (43%), Gaps = 43/345 (12%)
Query: 501 TFKTKSSYLSLATLQAYTSMHLFFQFKTTSPDGFILFNSGDGNDFIAVEL-VKGYIHYVF 559
+F T++SYL + + F FKTT G + N G DFI +EL + + F
Sbjct: 796 SFNTETSYLHFPAFHGELTADVCFFFKTTVSSGVFMENLGI-TDFIRIELRAPTEVTFSF 854
Query: 560 DLGNGPNVIKGNSDRPLNDNQWHNVVITRDNSNTHSLKVD---TKVVTQVINGAKNLDLK 616
D+GNGP + S P NDNQWH+V R N SL+VD K+ +G L L
Sbjct: 855 DVGNGPCEVTVQSPTPFNDNQWHHVRAER-NVKGASLQVDQLPQKMQPAPADGHVRLQLN 913
Query: 617 GDLYMAGLAQGMYSNLPKLVASRDGFQGCLASVDLNGRLPDLINDALHRSGQIERGCEGP 676
L++ G A + GF GC+ S+ LNG DL A G +E GC G
Sbjct: 914 SQLFIGGTA-----------TRQRGFLGCIRSLQLNGVALDLEERATVTPG-VEPGCAGH 961
Query: 677 STTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQCNDPGATYIFGKSGGLILYTWPAND 736
+T C N G C ++ G TCDC+ ++Y G C++ + Y +G + Y + +
Sbjct: 962 CST-YGHLCRNGGRCREKRRGVTCDCAFSAYDGPFCSNEISAYF--ATGSSMTYHFQEHY 1018
Query: 737 RPSTRSDRLAVGFSTTVKDGILV--------RIDSAPGLGDFLQLHIEQGKIGVVFNIGT 788
S S L S+ +D L R +P L ++ E+ ++ N G+
Sbjct: 1019 TLSENSSSLV---SSLYRDVTLTREMITLSFRTTRSPSLLLYVSSFYEEYLSVILANNGS 1075
Query: 789 VDISIKEER-----------TPVNDGKYHVVRFTRNGGNATLQVD 822
+ I K +R + DG+ H V+ R ++V+
Sbjct: 1076 LQIRYKLDRHQNPDAFTFDFKNMADGQLHQVKINREEAVVMVEVN 1120
Score = 84.3 bits (207), Expect = 5e-16
Identities = 75/286 (26%), Positives = 121/286 (42%), Gaps = 36/286 (12%)
Query: 27 NFMGCLKEVVYKNNDIRLELSRLARIADTKMKIYGEVVFKCENVATLDPINFETPEAYIS 86
+F GCL+ + Y D+ + LA+ ++ + G V F C T+ P+ F + +Y++
Sbjct: 328 SFHGCLENLYYNGVDV----TELAKKHKPQILMMGNVSFSCPQPQTV-PVTFLSSRSYLA 382
Query: 87 LPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFAVELLDGNLYL 146
LP + + S++F FRT G +LF G+ Q + F + L DG L L
Sbjct: 383 LPGNSGEDKVSVTFQFRTWNRAGHLLF--GELQRGSGS----------FVLFLKDGKLKL 430
Query: 147 LLDMGSGTIKVKATQKKANDGEWYHVDIQRDGRSGTISVNSRRT--PFTASGESEILDLE 204
L + + NDG+W+ V + V+ P A ++D
Sbjct: 431 SLFQAGQSPRNVTAGAGLNDGQWHSVSFSAKWSHMNVVVDDDTAVQPLVAV----LIDSG 486
Query: 205 GDMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEMQNAAG--- 261
Y GG N +G + L G+ GC+R + I K + + Q A G
Sbjct: 487 DTYYFGGCLGNSSGSGCKSPLG------GFQGCLRLITIG--DKAVDPILVQQGALGSFR 538
Query: 262 -VKSSCSRMSAKQCDSYPCKNNAVCKDGWNRFICDCTGTGYWGRTC 306
++ ++ + SY C++ C W+ F CDC GTGY G TC
Sbjct: 539 DLQIDSCGITDRCLPSY-CEHGGECSQSWDTFSCDCLGTGYTGETC 583
Score = 75.1 bits (183), Expect = 3e-13
Identities = 61/249 (24%), Positives = 104/249 (41%), Gaps = 43/249 (17%)
Query: 77 NFETPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFA 136
+F T +Y+ P ++ + + F F+TT +G+ + G DF
Sbjct: 796 SFNTETSYLHFPAFHGELTADVCFFFKTTVSSGVFMENLGI--------------TDFIR 841
Query: 137 VEL-LDGNLYLLLDMGSGTIKVKATQKKA-NDGEWYHVDIQRDGRSGTISVNS---RRTP 191
+EL + D+G+G +V ND +W+HV +R+ + ++ V+ + P
Sbjct: 842 IELRAPTEVTFSFDVGNGPCEVTVQSPTPFNDNQWHHVRAERNVKGASLQVDQLPQKMQP 901
Query: 192 FTASGESEILDLEGDMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIR 251
A G L L +++GG TA G++GCIR L ++G + ++
Sbjct: 902 APADGHVR-LQLNSQLFIGG---------------TATRQRGFLGCIRSLQLNGVALDLE 945
Query: 252 QLAEMQNAAGVKSSCSRMSAKQCDSYP--CKNNAVCKDGWNRFICDCTGTGYWGRTCERE 309
+ A + GV+ C A C +Y C+N C++ CDC + Y G C E
Sbjct: 946 ERATV--TPGVEPGC----AGHCSTYGHLCRNGGRCREKRRGVTCDCAFSAYDGPFCSNE 999
Query: 310 ASILSYDGS 318
S GS
Sbjct: 1000 ISAYFATGS 1008
Score = 52.4 bits (124), Expect = 2e-06
Identities = 71/340 (20%), Positives = 123/340 (36%), Gaps = 76/340 (22%)
Query: 98 ISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFAVELLDGNLYLLLDMGSGTIKV 157
IS F+ + NG++L G+ +EL+ G L L+ SG K+
Sbjct: 208 ISLKFKAMQSNGILLHREGQHGNH-------------ITLELIKGKLVFFLN--SGNAKL 252
Query: 158 KATQKKA--------NDGEWYHVDIQRDGRSGTISVNSRRTPFTASGESEILDLEGDMYL 209
+T +D W+ V I+ +V+ F A G+S LDL ++
Sbjct: 253 PSTIAPVTLTLGSLLDDQHWHSVLIELLDTQVNFTVDKHTHHFQAKGDSSNLDLNFEISF 312
Query: 210 GGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEMQNAAGVKSSCSRM 269
GG IL A + GC+ +L+ +G ++ +LA+ +
Sbjct: 313 GG--------ILSPGRSRAFTRKSFHGCLENLYYNG--VDVTELAKKHKPQILMMGNVSF 362
Query: 270 SAKQCDSYPCKNNAVCKDGWNRFICDCTGTGYWGRTCEREASILSYDGSMYMKIIMPMVM 329
S Q + P F+ + G + E + S
Sbjct: 363 SCPQPQTVPV-----------TFLSSRSYLALPGNSGEDKVS------------------ 393
Query: 330 HTEAEDVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLDCIRINCNSSKGP 389
V+F+F + G L+ + + + L L G++KL + + + P
Sbjct: 394 ------VTFQFRTWNRAGHLLFGELQRGSGSFVLFLKDGKLKLSL--------FQAGQSP 439
Query: 390 ETLYAGQKLNDNEWHTVRVVRRGKSLKLTVDDDVAEGTMV 429
+ AG LND +WH+V + + + VDDD A +V
Sbjct: 440 RNVTAGAGLNDGQWHSVSFSAKWSHMNVVVDDDTAVQPLV 479
Score = 48.5 bits (114), Expect = 3e-05
Identities = 86/357 (24%), Positives = 128/357 (35%), Gaps = 84/357 (23%)
Query: 391 TLYAGQKLNDNEWHTVRVVRRGKSLKLTVDD--DVAEGTMVGDHTRLEFHN--IETGIMT 446
T+ + NDN+WH VR R K L VD + H RL+ ++ G T
Sbjct: 864 TVQSPTPFNDNQWHHVRAERNVKGASLQVDQLPQKMQPAPADGHVRLQLNSQLFIGGTAT 923
Query: 447 EKRYISVVPSSFIGHLQSLMFNGL-----------------------LYIDLCKNG---- 479
+R F+G ++SL NG+ Y LC+NG
Sbjct: 924 RQR-------GFLGCIRSLQLNGVALDLEERATVTPGVEPGCAGHCSTYGHLCRNGGRCR 976
Query: 480 ---------------DIDYC--ELKARFGLRNIIA----DPVTFKTKSSYL--SLATLQA 516
D +C E+ A F + + + T SS L SL
Sbjct: 977 EKRRGVTCDCAFSAYDGPFCSNEISAYFATGSSMTYHFQEHYTLSENSSSLVSSLYRDVT 1036
Query: 517 YTSMHLFFQFKTTSPDGFILFNSGDGNDFIAVELVKG---YIHYVFDLGNGPNVIKGNSD 573
T + F+TT +L+ S ++++V L I Y D P+ +
Sbjct: 1037 LTREMITLSFRTTRSPSLLLYVSSFYEEYLSVILANNGSLQIRYKLDRHQNPDAFTFDF- 1095
Query: 574 RPLNDNQWHNVVITRDNSNTHSLKVDTKVVTQVI-------NGAKNLDLKGDLYMAGLAQ 626
+ + D Q H V I R+ + ++V+ QVI N K+L L L AG
Sbjct: 1096 KNMADGQLHQVKINREEA-VVMVEVNQSAKKQVILSSGTEFNAVKSLILGKVLEAAG--- 1151
Query: 627 GMYSNLPKLVASRDGFQGCLASVDLNGRLPDLINDALHRSGQIE---RGCEGPSTTC 680
++ A+ GF GCL++V P + AL SG RG P C
Sbjct: 1152 ---ADPDTRRAATSGFTGCLSAVRFGRAAP--LKAALRPSGPSRVTVRGHVAPMARC 1203
Score = 43.1 bits (100), Expect = 0.001
Identities = 34/123 (27%), Positives = 56/123 (45%), Gaps = 6/123 (4%)
Query: 749 FSTTVKDGILVRIDSAPGLGDFLQLHIEQG-KIGVVFNIGTVDISIK-EERTPVNDGKYH 806
F TTV G+ + G+ DF+++ + ++ F++G + + TP ND ++H
Sbjct: 821 FKTTVSSGVFME---NLGITDFIRIELRAPTEVTFSFDVGNGPCEVTVQSPTPFNDNQWH 877
Query: 807 VVRFTRNGGNATLQVDNWPVNEHYPTGRQLTIFNTQAQIAIGG-KDKGRLFQGQLSGLYY 865
VR RN A+LQVD P +Q+ IGG + R F G + L
Sbjct: 878 HVRAERNVKGASLQVDQLPQKMQPAPADGHVRLQLNSQLFIGGTATRQRGFLGCIRSLQL 937
Query: 866 DGL 868
+G+
Sbjct: 938 NGV 940
Score = 35.4 bits (80), Expect = 0.29
Identities = 47/202 (23%), Positives = 80/202 (39%), Gaps = 25/202 (12%)
Query: 719 YIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQG 778
Y G+S +LYT R D +++ F +GIL+ + G + + L + +G
Sbjct: 185 YFDGQSA--LLYTLDKKPLKPIR-DVISLKFKAMQSNGILLHREGQHG--NHITLELIKG 239
Query: 779 KIGVVFNIGTVDISIKEERTPV--------NDGKYHVVRFTRNGGNATLQVDNWPVNEHY 830
K+ VF + + + + PV +D +H V VD H+
Sbjct: 240 KL--VFFLNSGNAKLPSTIAPVTLTLGSLLDDQHWHSVLIELLDTQVNFTVDKH--THHF 295
Query: 831 PTGRQLTIFNTQAQIAIGG-KDKGRL-------FQGQLSGLYYDGLKVLNMAAENNPNIK 882
+ + +I+ GG GR F G L LYY+G+ V +A ++ P I
Sbjct: 296 QAKGDSSNLDLNFEISFGGILSPGRSRAFTRKSFHGCLENLYYNGVDVTELAKKHKPQIL 355
Query: 883 INGSVRLVGEVPSILGTTQTTS 904
+ G+V P + T +S
Sbjct: 356 MMGNVSFSCPQPQTVPVTFLSS 377
>gi|4505463 contactin associated protein 1 precursor [Homo sapiens]
Length = 1384
Score = 115 bits (288), Expect = 2e-25
Identities = 108/422 (25%), Positives = 184/422 (43%), Gaps = 22/422 (5%)
Query: 306 CEREASILSYDGSMYMKIIMPMVMHTEAEDV-SFRFMSQRAYGLLVATTSRDSADTLRLE 364
C +A IL +DG + P + DV +F F ++ GLL+ D + LE
Sbjct: 168 CPYKADILYFDGDDAISYRFPRGVSRSLWDVFAFSFKTEEKDGLLLHAEGAQG-DYVTLE 226
Query: 365 LDGGRVKLMVNLDCIRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTVDDDVA 424
L+G + L ++L I G T+ AG LND WH VRV R G+ + T+D V
Sbjct: 227 LEGAHLLLHMSLGSSPIQ--PRPGHTTVSAGGVLNDQHWHYVRVDRFGRDVNFTLDGYVQ 284
Query: 425 EGTMVGDHTRLEFHNIET-----GIMTEKRYISVVPSSFIGHLQSLMFNGLLYIDLC--K 477
+ GD RL N++T G++ R +F G +++++FN + DL +
Sbjct: 285 RFILNGDFERL---NLDTEMFIGGLVGAARKNLAYRHNFRGCIENVIFNRVNIADLAVRR 341
Query: 478 NGDIDYCELKARFGLRNIIADPVTFKTKSSYLSLATLQAYTSMHLFFQFKTTSPDGFILF 537
+ I + E K F + + P+ F +++ + + + F+F+T G +LF
Sbjct: 342 HSRITF-EGKVAFRCLDPVPHPINFGGPHNFVQVPGFPRRGRLAVSFRFRTWDLTGLLLF 400
Query: 538 NS-GDGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSDRPLNDNQWHNVVITRDNSNTHSL 596
+ GDG + + L +G ++ V +G ++ + LND WH V ++ +
Sbjct: 401 SRLGDGLGHVELTLSEGQVN-VSIAQSGRKKLQFAAGYRLNDGFWHEVNFVAQENHA-VI 458
Query: 597 KVDTKVVTQVINGAKNLDLKGDLYMAGLAQGMYSNLPKLVASRDGFQGCLASVDLNGRLP 656
+D +V L G Y G S +++ F GC+ + ++G+L
Sbjct: 459 SIDDVEGAEVRVSYPLLIRTGTSYFFGGCPKPASRWD-CHSNQTAFHGCMELLKVDGQLV 517
Query: 657 DLINDALHRSG---QIERGCEGPSTTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQCN 713
+L R G ++ G + C + C + G C Q W+ F C C +T Y G C+
Sbjct: 518 NLTLVEGRRLGFYAEVLFDTCGITDRCSPNMCEHDGRCYQSWDDFICYCELTGYKGETCH 577
Query: 714 DP 715
P
Sbjct: 578 TP 579
Score = 84.7 bits (208), Expect = 4e-16
Identities = 74/320 (23%), Positives = 127/320 (39%), Gaps = 53/320 (16%)
Query: 2 LGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDIRLELSRLARIADTKMKIYG 61
L D ++GG A +NF GC++ V++ R+ ++ LA +++ G
Sbjct: 295 LNLDTEMFIGGLVGAAR-KNLAYRHNFRGCIENVIFN----RVNIADLAVRRHSRITFEG 349
Query: 62 EVVFKCENVATLDPINFETPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQER 121
+V F+C + PINF P ++ +P + + ++SF FRT + GL+LF+
Sbjct: 350 KVAFRCLDPVP-HPINFGGPHNFVQVPGFPRRGRLAVSFRFRTWDLTGLLLFSR------ 402
Query: 122 KDARSQKNTKVDFFAVELLDGNLYLLLDMGSGTIKVKATQK-----------KANDGEWY 170
L DG ++ L + G + V Q + NDG W+
Sbjct: 403 -----------------LGDGLGHVELTLSEGQVNVSIAQSGRKKLQFAAGYRLNDGFWH 445
Query: 171 HVDIQRDGRSGTISVNSRRTPFTASGESEILDLEGDMYLGGLPENRAGLILPTELWTAML 230
V+ IS++ ++ + GG P+ P W
Sbjct: 446 EVNFVAQENHAVISIDDVEGAEVRVSYPLLIRTGTSYFFGGCPK-------PASRWDCHS 498
Query: 231 NY-GYVGCIRDLFIDGRSKNIRQLAEMQ---NAAGVKSSCSRMSAKQCDSYPCKNNAVCK 286
N + GC+ L +DG+ N+ + + A + +C +C C+++ C
Sbjct: 499 NQTAFHGCMELLKVDGQLVNLTLVEGRRLGFYAEVLFDTCG--ITDRCSPNMCEHDGRCY 556
Query: 287 DGWNRFICDCTGTGYWGRTC 306
W+ FIC C TGY G TC
Sbjct: 557 QSWDDFICYCELTGYKGETC 576
Score = 82.4 bits (202), Expect = 2e-15
Identities = 101/427 (23%), Positives = 174/427 (40%), Gaps = 97/427 (22%)
Query: 479 GDIDYCELKARFGLRNIIA-------DPVTFKTKSSYLSLATLQAYTSMHLFFQFKTTSP 531
GD + +A+F LR + + ++F T ++ L ++A S+ + F F+T++P
Sbjct: 760 GDTNRSTSEAQFFLRPLRCYGDRNSWNTISFHTGAA-LRFPPIRANHSLDVSFYFRTSAP 818
Query: 532 DGFILFNSGDG-----NDFIAVEL-VKGYIHYVFDLGNGP-NVIKGNSDRPLNDNQWHNV 584
G L N G ++ VEL + + FD+GNG N+ + D ND++WH +
Sbjct: 819 SGVFLENMGGPYCQWRRPYVRVELNTSRDVVFAFDVGNGDENLTVHSDDFEFNDDEWH-L 877
Query: 585 VITRDNSNTHSLKVDTKVVTQVINGAKNLDLKGDLYMAGLAQGMYSNLPKLVASRDGFQG 644
V N L+VD + + + L+ ++M Q +Y +L R F G
Sbjct: 878 VRAEINVKQARLRVDHRPWV-----LRPMPLQTYIWME-YDQPLYVGSAEL--KRRPFVG 929
Query: 645 CLASVDLNGRLPDLINDALHRSGQIERGCEGPSTTCQEDS------CANQGVCMQQWEGF 698
CL ++ LNG +L A EG S C C + G C++++ +
Sbjct: 930 CLRAMRLNGVTLNLEGRA--------NASEGTSPNCTGHCAHPRLPCFHGGRCVERYSYY 981
Query: 699 TCDCSMTSYSGNQCN-------DPGA---------------------------------- 717
TCDC +T++ G CN +PG
Sbjct: 982 TCDCDLTAFDGPYCNHDIGGFFEPGTWMRYNLQSALRSAAREFSHMLSRPVPGYEPGYIP 1041
Query: 718 -----TYIFGKSG-GLILYTWPANDRP---------STRSDRLAVGFSTTVKDGILVRID 762
Y+ G G G L +P RP + + ++ FST+ +L+ +
Sbjct: 1042 GYDTPGYVPGYHGPGYRLPDYPRPGRPVPGYRGPVYNVTGEEVSFSFSTSSAPAVLLYVS 1101
Query: 763 SAPGLGDFLQLHI-EQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQV 821
S + D++ + I + G + + + +GT + PV DG+ H + TR N +QV
Sbjct: 1102 SF--VRDYMAVLIKDDGTLQLRYQLGTSPYVYQLTTRPVTDGQPHSINITRVYRNLFIQV 1159
Query: 822 DNWPVNE 828
D +P+ E
Sbjct: 1160 DYFPLTE 1166
Score = 52.8 bits (125), Expect = 2e-06
Identities = 58/269 (21%), Positives = 105/269 (39%), Gaps = 38/269 (14%)
Query: 76 INFETPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQ---ERKDARSQKNTKV 132
I+F T A + P +SF FRT+ P+G+ L G P R R + NT
Sbjct: 788 ISFHTGAA-LRFPPIRANHSLDVSFYFRTSAPSGVFLENMGGPYCQWRRPYVRVELNTSR 846
Query: 133 DFFAVELLDGNLYLLLDMGSG--TIKVKATQKKANDGEWYHVDIQRDGRSGTISVNSRRT 190
D + D+G+G + V + + ND EW+ V + + + + V+ R
Sbjct: 847 D----------VVFAFDVGNGDENLTVHSDDFEFNDDEWHLVRAEINVKQARLRVDHRPW 896
Query: 191 PFTASGESEILDLEGD--MYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSK 248
+ +E D +Y+G R +VGC+R + ++G +
Sbjct: 897 VLRPMPLQTYIWMEYDQPLYVGSAELKRRP---------------FVGCLRAMRLNGVTL 941
Query: 249 NIRQLAEMQNAAGVKSSCSRMSAKQCDSYPCKNNAVCKDGWNRFICDCTGTGYWGRTCER 308
N+ A G +C+ A PC + C + ++ + CDC T + G C
Sbjct: 942 NLEGRANASE--GTSPNCTGHCAHP--RLPCFHGGRCVERYSYYTCDCDLTAFDGPYCNH 997
Query: 309 EASILSYDGSMYMKIIMPMVMHTEAEDVS 337
+ ++ +M+ + + + A + S
Sbjct: 998 DIGGF-FEPGTWMRYNLQSALRSAAREFS 1025
Score = 52.4 bits (124), Expect = 2e-06
Identities = 47/206 (22%), Positives = 87/206 (42%), Gaps = 37/206 (17%)
Query: 25 SNNFMGCLKEVVYKNNDIRLELS-RLARIADTKMKIYGEV-----VFKCENVATL----- 73
++ F G + E +D+ + R RI G++ ++ C A +
Sbjct: 120 NSTFFGNVNESAVVRHDLHFHFTARYIRIVPLAWNPRGKIGLRLGLYGCPYKADILYFDG 179
Query: 74 -DPINFETPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKV 132
D I++ P +S W+ +F F+T E +GL+L G +
Sbjct: 180 DDAISYRFPRG-VSRSLWDV-----FAFSFKTEEKDGLLLHAEG-------------AQG 220
Query: 133 DFFAVELLDGNLYLLLDMGSGTIKVKATQKKA------NDGEWYHVDIQRDGRSGTISVN 186
D+ +EL +L L + +GS I+ + ND W++V + R GR +++
Sbjct: 221 DYVTLELEGAHLLLHMSLGSSPIQPRPGHTTVSAGGVLNDQHWHYVRVDRFGRDVNFTLD 280
Query: 187 SRRTPFTASGESEILDLEGDMYLGGL 212
F +G+ E L+L+ +M++GGL
Sbjct: 281 GYVQRFILNGDFERLNLDTEMFIGGL 306
Score = 42.0 bits (97), Expect = 0.003
Identities = 38/168 (22%), Positives = 69/168 (41%), Gaps = 20/168 (11%)
Query: 743 DRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPV-- 800
D A F T KDG+L+ + A GD++ L +E + + ++G+ I + T V
Sbjct: 197 DVFAFSFKTEEKDGLLLHAEGAQ--GDYVTLELEGAHLLLHMSLGSSPIQPRPGHTTVSA 254
Query: 801 ----NDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGRQLTIFNTQAQIAIGGKDKG--- 853
ND +H VR R G + +D + + + N ++ IGG
Sbjct: 255 GGVLNDQHWHYVRVDRFGRDVNFTLDGYV--QRFILNGDFERLNLDTEMFIGGLVGAARK 312
Query: 854 -----RLFQGQLSGLYYDGLKVLNMAAENNPNIKINGSV--RLVGEVP 894
F+G + + ++ + + ++A + I G V R + VP
Sbjct: 313 NLAYRHNFRGCIENVIFNRVNIADLAVRRHSRITFEGKVAFRCLDPVP 360
Score = 42.0 bits (97), Expect = 0.003
Identities = 41/144 (28%), Positives = 66/144 (45%), Gaps = 8/144 (5%)
Query: 518 TSMHLFFQFKTTSPDGFILFNSGDGNDFIAVELVK--GYIHYVFDLGNGPNVIKGNSDRP 575
T + F F T+S +L+ S D++AV L+K G + + LG P V + + RP
Sbjct: 1080 TGEEVSFSFSTSSAPAVLLYVSSFVRDYMAV-LIKDDGTLQLRYQLGTSPYVYQLTT-RP 1137
Query: 576 LNDNQWHNVVITRDNSNTHSLKVDTKVVTQ---VINGAKNLDLKGDLYMAGLAQGMYSNL 632
+ D Q H++ ITR N ++VD +T+ + LD LY+ + + +
Sbjct: 1138 VTDGQPHSINITRVYRNLF-IQVDYFPLTEQKFSLLVDSQLDSPKALYLGRVMETGVIDP 1196
Query: 633 PKLVASRDGFQGCLASVDLNGRLP 656
+ GF GCL+ V N P
Sbjct: 1197 EIQRYNTPGFSGCLSGVRFNNVAP 1220
>gi|33469931 EGF-like, fibronectin type III and laminin G domains
isoform 2 [Homo sapiens]
Length = 775
Score = 113 bits (282), Expect = 1e-24
Identities = 155/656 (23%), Positives = 258/656 (39%), Gaps = 108/656 (16%)
Query: 267 SRMSAKQCDSYPCKNNAVCKDG--WNRFICDCTGTGYWGRTCEREASIL--SYDGSMYMK 322
SR+ CD C ++ C + W C CT G G +C + I + G Y+
Sbjct: 106 SRLFDMPCDETLCSADSFCVNDYTWGGSRCQCT-LGKGGESCSEDIVIQYPQFFGHSYVT 164
Query: 323 IIMPMVMHTEAEDVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLDCIRIN 382
P+ +A ++ F ++ GLL+ + G + L + ++
Sbjct: 165 F-EPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGR-------GDFMSLAIIRRSLQFR 216
Query: 383 CNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTVDDDV-AEGTMVGDHTRLEFHNIE 441
N G + + K+ WHTV + R G + L +++ G G ++++ F
Sbjct: 217 FNCGTGVAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRT-- 274
Query: 442 TGIMTEKRYISVVPSS------------FIGHLQSLMFNGLLYIDL-------------- 475
Y+ PS+ F G +QSL NG ID+
Sbjct: 275 ------PLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRR-IDMRPWPLGKALSGADV 327
Query: 476 --CKNGDIDYCELKARFGLRNIIAD------PVTFKTK--------------SSYLSLAT 513
C +G D I AD P+ FK + S S A
Sbjct: 328 GECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAA 387
Query: 514 L------QAYTS-MHLFFQFKTTSPDGFILFNSGDGN-DFIAVELVKGYIHYVFDLGNGP 565
Q Y S M F+ S DG +L++ G+ DF+++ L G++ + FD G+G
Sbjct: 388 TPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGT 447
Query: 566 NVIKGNSDRPLNDNQWHNVVITRDNSNTHSLKVDTKVVTQVI--NGAKNLDLKGDLYMAG 623
V++ S+ PL WH + ++R N L+VD + + + + G + D+++ G
Sbjct: 448 GVLR--SEDPLTLGNWHELRVSRTAKNG-ILQVDKQKIVEGMAEGGFTQIKCNTDIFIGG 504
Query: 624 LAQGMYSNLPKLVASRDGFQGCLASVDLNGRLPDLINDALHRSGQIERGCEGPSTTCQED 683
+ Y ++ K F G + + LN R + +D SG E + C
Sbjct: 505 VPN--YDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHD--FTSGV---NVENAAHPCVRA 557
Query: 684 SCANQGVCMQQWEGFTCDCSMTSYSGNQCNDPGATYI-----FGKSGGLILYTWP-ANDR 737
CA+ G C + EG+ CDC + + G C I G+S + Y P R
Sbjct: 558 PCAHGGSCRPRKEGYDCDCPL-GFEGLHCQKAIIEAIEIPQFIGRS--YLTYDNPDILKR 614
Query: 738 PSTRSDRLAVGFSTTVKDGILVRIDSAP--GLGDFLQLHIEQGKIGVVFNIGTVDISIKE 795
S + + F TT KDG+L+ +P DF+ L + G + +N+G+ SI
Sbjct: 615 VSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMV 674
Query: 796 ERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTG--RQLTIFNTQAQIAIGG 849
+ NDG++H V+ R+G + + VD++ G RQL N + +GG
Sbjct: 675 NGS-FNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQL---NINGALYVGG 726
Score = 87.0 bits (214), Expect = 8e-17
Identities = 102/467 (21%), Positives = 189/467 (40%), Gaps = 96/467 (20%)
Query: 9 YVGGSPSTADLPGSPVSNN-FMGCLKEVVYKNNDIRLELSRLAR-------------IAD 54
Y+GG+PS L + +N F GC++ + I + L + I D
Sbjct: 277 YLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICD 336
Query: 55 TKMKIYGEV--VFKCENVATLDPINF-----------------ETPEAYISLPKWNTKRM 95
I+G K ++ L P+ F E+ +Y + P W +
Sbjct: 337 EASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATP-WPLEPQ 395
Query: 96 GSISF-----DFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFAVELLDGNLYLLLDM 150
+SF FR +G++L+++ D S+ DF ++ L G++ D
Sbjct: 396 HYLSFMEFEITFRPDSGDGVLLYSY-------DTGSK-----DFLSINLAGGHVEFRFDC 443
Query: 151 GSGTIKVKATQKKANDGEWYHVDIQRDGRSGTISVNSRR-TPFTASGESEILDLEGDMYL 209
GSGT V ++ G W+ + + R ++G + V+ ++ A G + D+++
Sbjct: 444 GSGT-GVLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFI 502
Query: 210 GGLP-----ENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEMQNAAGVKS 264
GG+P + +G++ P + G I+ + ++ R+ +++ + + V++
Sbjct: 503 GGVPNYDDVKKNSGVLKP-----------FSGSIQKIILNDRTIHVKH--DFTSGVNVEN 549
Query: 265 SCSRMSAKQCDSYPCKNNAVCKDGWNRFICDCTGTGYWGRTCEREA----SILSYDGSMY 320
+ A C PC + C+ + CDC G+ G C++ I + G Y
Sbjct: 550 A-----AHPCVRAPCAHGGSCRPRKEGYDCDCP-LGFEGLHCQKAIIEAIEIPQFIGRSY 603
Query: 321 MKIIMPMVMHTEA---EDVSFRFMSQRAYGLLV---ATTSRDSADTLRLELDGGRVKLMV 374
+ P ++ + +V RF + GLL+ + R ++D + L L G +
Sbjct: 604 LTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSY 663
Query: 375 NLDCIRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTVDD 421
NL G ++ ND WH V+ VR G+S K+TVDD
Sbjct: 664 NL---------GSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDD 701
Score = 85.9 bits (211), Expect = 2e-16
Identities = 96/396 (24%), Positives = 168/396 (42%), Gaps = 46/396 (11%)
Query: 88 PKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFAVELLDGNLYLL 147
P N+ + I+ +FR +GL+L+ ++ + DF ++ ++ +L
Sbjct: 167 PLKNSYQAFQITLEFRAEAEDGLLLY----------CGENEHGRGDFMSLAIIRRSLQFR 216
Query: 148 LDMGSGTIKVKATQKKANDGEWYHVDIQRDGRSGTISVNSRRTPFT--ASGESEILDLEG 205
+ G+G + + ++ K G W+ V + RDG +G + +N+ TP T + G+ +
Sbjct: 217 FNCGTG-VAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNN-GTPVTGQSQGQYSKITFRT 274
Query: 206 DMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEMQNAAGVKSS 265
+YLGG P + L+ T N G+ GC++ L ++GR ++R + +G +
Sbjct: 275 PLYLGGAP-SAYWLVRATG-----TNRGFQGCVQSLAVNGRRIDMRPWPLGKALSG--AD 326
Query: 266 CSRMSAKQCDSYPCKNNAVCKD-GWNRFICDCTGTGYWGRTCER--EASILSYDGSMYMK 322
S+ CD C + C + +IC C G+ GR CE +I + S+
Sbjct: 327 VGECSSGICDEASCIHGGTCTAIKADSYICLCP-LGFKGRHCEDAFTLTIPQFRESLRSY 385
Query: 323 IIMPMVM----HTEAEDVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLDC 378
P + + + F G+L+ + S D L + L GG V+
Sbjct: 386 AATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVE------- 438
Query: 379 IRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTVD-DDVAEGTMVGDHTRLEF 437
R +C S G L + L WH +RV R K+ L VD + EG G T+++
Sbjct: 439 FRFDCGSGTG--VLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKC 496
Query: 438 HNIETGIMTEKRYISVVPSS-----FIGHLQSLMFN 468
N + I Y V +S F G +Q ++ N
Sbjct: 497 -NTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILN 531
>gi|33469929 EGF-like, fibronectin type III and laminin G domains
isoform 1 [Homo sapiens]
Length = 1009
Score = 113 bits (282), Expect = 1e-24
Identities = 155/656 (23%), Positives = 258/656 (39%), Gaps = 108/656 (16%)
Query: 267 SRMSAKQCDSYPCKNNAVCKDG--WNRFICDCTGTGYWGRTCEREASIL--SYDGSMYMK 322
SR+ CD C ++ C + W C CT G G +C + I + G Y+
Sbjct: 340 SRLFDMPCDETLCSADSFCVNDYTWGGSRCQCT-LGKGGESCSEDIVIQYPQFFGHSYVT 398
Query: 323 IIMPMVMHTEAEDVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLDCIRIN 382
P+ +A ++ F ++ GLL+ + G + L + ++
Sbjct: 399 F-EPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGR-------GDFMSLAIIRRSLQFR 450
Query: 383 CNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTVDDDV-AEGTMVGDHTRLEFHNIE 441
N G + + K+ WHTV + R G + L +++ G G ++++ F
Sbjct: 451 FNCGTGVAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRT-- 508
Query: 442 TGIMTEKRYISVVPSS------------FIGHLQSLMFNGLLYIDL-------------- 475
Y+ PS+ F G +QSL NG ID+
Sbjct: 509 ------PLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRR-IDMRPWPLGKALSGADV 561
Query: 476 --CKNGDIDYCELKARFGLRNIIAD------PVTFKTK--------------SSYLSLAT 513
C +G D I AD P+ FK + S S A
Sbjct: 562 GECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAA 621
Query: 514 L------QAYTS-MHLFFQFKTTSPDGFILFNSGDGN-DFIAVELVKGYIHYVFDLGNGP 565
Q Y S M F+ S DG +L++ G+ DF+++ L G++ + FD G+G
Sbjct: 622 TPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGT 681
Query: 566 NVIKGNSDRPLNDNQWHNVVITRDNSNTHSLKVDTKVVTQVI--NGAKNLDLKGDLYMAG 623
V++ S+ PL WH + ++R N L+VD + + + + G + D+++ G
Sbjct: 682 GVLR--SEDPLTLGNWHELRVSRTAKNG-ILQVDKQKIVEGMAEGGFTQIKCNTDIFIGG 738
Query: 624 LAQGMYSNLPKLVASRDGFQGCLASVDLNGRLPDLINDALHRSGQIERGCEGPSTTCQED 683
+ Y ++ K F G + + LN R + +D SG E + C
Sbjct: 739 VPN--YDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHD--FTSGV---NVENAAHPCVRA 791
Query: 684 SCANQGVCMQQWEGFTCDCSMTSYSGNQCNDPGATYI-----FGKSGGLILYTWP-ANDR 737
CA+ G C + EG+ CDC + + G C I G+S + Y P R
Sbjct: 792 PCAHGGSCRPRKEGYDCDCPL-GFEGLHCQKAIIEAIEIPQFIGRS--YLTYDNPDILKR 848
Query: 738 PSTRSDRLAVGFSTTVKDGILVRIDSAP--GLGDFLQLHIEQGKIGVVFNIGTVDISIKE 795
S + + F TT KDG+L+ +P DF+ L + G + +N+G+ SI
Sbjct: 849 VSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMV 908
Query: 796 ERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTG--RQLTIFNTQAQIAIGG 849
+ NDG++H V+ R+G + + VD++ G RQL N + +GG
Sbjct: 909 NGS-FNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQL---NINGALYVGG 960
Score = 87.0 bits (214), Expect = 8e-17
Identities = 102/467 (21%), Positives = 189/467 (40%), Gaps = 96/467 (20%)
Query: 9 YVGGSPSTADLPGSPVSNN-FMGCLKEVVYKNNDIRLELSRLAR-------------IAD 54
Y+GG+PS L + +N F GC++ + I + L + I D
Sbjct: 511 YLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICD 570
Query: 55 TKMKIYGEV--VFKCENVATLDPINF-----------------ETPEAYISLPKWNTKRM 95
I+G K ++ L P+ F E+ +Y + P W +
Sbjct: 571 EASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATP-WPLEPQ 629
Query: 96 GSISF-----DFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFAVELLDGNLYLLLDM 150
+SF FR +G++L+++ D S+ DF ++ L G++ D
Sbjct: 630 HYLSFMEFEITFRPDSGDGVLLYSY-------DTGSK-----DFLSINLAGGHVEFRFDC 677
Query: 151 GSGTIKVKATQKKANDGEWYHVDIQRDGRSGTISVNSRR-TPFTASGESEILDLEGDMYL 209
GSGT V ++ G W+ + + R ++G + V+ ++ A G + D+++
Sbjct: 678 GSGT-GVLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFI 736
Query: 210 GGLP-----ENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEMQNAAGVKS 264
GG+P + +G++ P + G I+ + ++ R+ +++ + + V++
Sbjct: 737 GGVPNYDDVKKNSGVLKP-----------FSGSIQKIILNDRTIHVKH--DFTSGVNVEN 783
Query: 265 SCSRMSAKQCDSYPCKNNAVCKDGWNRFICDCTGTGYWGRTCEREA----SILSYDGSMY 320
+ A C PC + C+ + CDC G+ G C++ I + G Y
Sbjct: 784 A-----AHPCVRAPCAHGGSCRPRKEGYDCDCP-LGFEGLHCQKAIIEAIEIPQFIGRSY 837
Query: 321 MKIIMPMVMHTEA---EDVSFRFMSQRAYGLLV---ATTSRDSADTLRLELDGGRVKLMV 374
+ P ++ + +V RF + GLL+ + R ++D + L L G +
Sbjct: 838 LTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSY 897
Query: 375 NLDCIRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTVDD 421
NL G ++ ND WH V+ VR G+S K+TVDD
Sbjct: 898 NL---------GSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDD 935
Score = 85.9 bits (211), Expect = 2e-16
Identities = 96/396 (24%), Positives = 168/396 (42%), Gaps = 46/396 (11%)
Query: 88 PKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFAVELLDGNLYLL 147
P N+ + I+ +FR +GL+L+ ++ + DF ++ ++ +L
Sbjct: 401 PLKNSYQAFQITLEFRAEAEDGLLLY----------CGENEHGRGDFMSLAIIRRSLQFR 450
Query: 148 LDMGSGTIKVKATQKKANDGEWYHVDIQRDGRSGTISVNSRRTPFT--ASGESEILDLEG 205
+ G+G + + ++ K G W+ V + RDG +G + +N+ TP T + G+ +
Sbjct: 451 FNCGTG-VAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNN-GTPVTGQSQGQYSKITFRT 508
Query: 206 DMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEMQNAAGVKSS 265
+YLGG P + L+ T N G+ GC++ L ++GR ++R + +G +
Sbjct: 509 PLYLGGAP-SAYWLVRATG-----TNRGFQGCVQSLAVNGRRIDMRPWPLGKALSG--AD 560
Query: 266 CSRMSAKQCDSYPCKNNAVCKD-GWNRFICDCTGTGYWGRTCER--EASILSYDGSMYMK 322
S+ CD C + C + +IC C G+ GR CE +I + S+
Sbjct: 561 VGECSSGICDEASCIHGGTCTAIKADSYICLCP-LGFKGRHCEDAFTLTIPQFRESLRSY 619
Query: 323 IIMPMVM----HTEAEDVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLDC 378
P + + + F G+L+ + S D L + L GG V+
Sbjct: 620 AATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVE------- 672
Query: 379 IRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTVD-DDVAEGTMVGDHTRLEF 437
R +C S G L + L WH +RV R K+ L VD + EG G T+++
Sbjct: 673 FRFDCGSGTG--VLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKC 730
Query: 438 HNIETGIMTEKRYISVVPSS-----FIGHLQSLMFN 468
N + I Y V +S F G +Q ++ N
Sbjct: 731 -NTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILN 765
>gi|47519929 cell recognition molecule CASPR3 [Homo sapiens]
Length = 1288
Score = 112 bits (279), Expect = 2e-24
Identities = 107/418 (25%), Positives = 176/418 (42%), Gaps = 20/418 (4%)
Query: 306 CEREASILSYDGSMYMKIIMPMVMHTEAEDV-SFRFMSQRAYGLLVATTSRDSADTLRLE 364
C ++ ++ +DG + + DV S +F + ++ G+L+ + + + LE
Sbjct: 177 CAYKSEVVYFDGQSALLYRLDKKPLKPIRDVISLKFKAMQSNGILLHREGQHG-NHITLE 235
Query: 365 LDGGRVKLMVNLDCIRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTVDDDVA 424
L G++ +N ++ S+ P TL G L+D WH+V + + TVD
Sbjct: 236 LIKGKLVFFLNSGNAKLP--STIAPVTLTLGSLLDDQHWHSVLIELLDTQVNFTVDKHTH 293
Query: 425 EGTMVGDHTRLEFHNIET---GIMTEKRYISVVPSSFIGHLQSLMFNGLLYIDLCKNGDI 481
GD + L+ N E GI T R + SF G L++L +NG+ +L K
Sbjct: 294 HFQAKGDSSYLDL-NFEISFGGIPTPGRSRAFRRKSFHGCLENLYYNGVDVTELAKKHKP 352
Query: 482 DYCEL-KARFGLRNIIADPVTFKTKSSYLSLATLQAYTSMHLFFQFKTTSPDGFILFNS- 539
+ F PVTF + SYL+L + + FQF+T + G +LF
Sbjct: 353 QILMMGNVSFSCPQPQTVPVTFLSSRSYLALPGNSGEDKVSVTFQFRTWNRAGHLLFGEL 412
Query: 540 GDGNDFIAVELVKGYIHY-VFDLGNGPNVIKGNSDRPLNDNQWHNVVITRDNSNTHSLKV 598
G+ + L G + +F G P + + LND QWH+V + S+ + +
Sbjct: 413 RRGSGSFVLFLKDGKLKLSLFQPGQSPRNVTAGAG--LNDGQWHSVSFSAKWSHMNVVVD 470
Query: 599 DTKVVTQVINGAKNLDLKGDLYMAGLAQGMYSNLPKLVASRDGFQGCLASVDLNGRLPDL 658
D V ++ A +D Y G + K + GFQGCL + + + D
Sbjct: 471 DDTAVQPLV--AVLIDSGDTYYFGGCLDNSSGSGCK--SPLGGFQGCLRLITIGDKAVDP 526
Query: 659 I---NDALHRSGQIERGCEGPSTTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQCN 713
I AL ++ G + C C + G C Q W+ F+CDC T Y+G C+
Sbjct: 527 ILVQQGALGSFRDLQIDSCGITDRCLPSYCEHGGECSQSWDTFSCDCLGTGYTGETCH 584
Score = 110 bits (276), Expect = 5e-24
Identities = 98/342 (28%), Positives = 149/342 (43%), Gaps = 37/342 (10%)
Query: 501 TFKTKSSYLSLATLQAYTSMHLFFQFKTTSPDGFILFNSGDGNDFIAVEL-VKGYIHYVF 559
+F T++SYL + + F FKTT G + N G DFI +EL + + F
Sbjct: 796 SFNTETSYLHFPAFHGELTADVCFFFKTTVSSGVFMENLGI-TDFIRIELRAPTEVTFSF 854
Query: 560 DLGNGPNVIKGNSDRPLNDNQWHNVVITRDNSNTHSLKVD---TKVVTQVINGAKNLDLK 616
D+GNGP + S P NDNQWH+V R N SL+VD K+ +G L L
Sbjct: 855 DVGNGPCEVTVQSPTPFNDNQWHHVRAER-NVKGASLQVDQLPQKMQPAPADGHVRLQLN 913
Query: 617 GDLYMAGLAQGMYSNLPKLVASRDGFQGCLASVDLNGRLPDLINDALHRSGQIERGCEGP 676
L++ G A + GF GC+ S+ LNG DL A G +E GC G
Sbjct: 914 SQLFIGGTA-----------TRQRGFLGCIRSLQLNGVALDLEERATVTPG-VEPGCAGH 961
Query: 677 STTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQCNDPGATYIFGKSGGLILYTWPAND 736
+T C N G C ++ G TCDC+ ++Y G C++ + Y +G + Y + +
Sbjct: 962 CST-YGHLCRNGGRCREKRRGVTCDCAFSAYDGPFCSNEISAYF--ATGSSMTYHFQEHY 1018
Query: 737 RPSTRSDRLAVGFS---TTVKDGILV--RIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDI 791
S S L T ++ I + R P L ++ E+ ++ N G++ I
Sbjct: 1019 TLSENSSSLVSSLHRDVTLTREMITLSFRTTRTPSLLLYVSSFYEEYLSVILANNGSLQI 1078
Query: 792 SIKEER-----------TPVNDGKYHVVRFTRNGGNATLQVD 822
K +R + DG+ H V+ R ++V+
Sbjct: 1079 RYKLDRHQNPDAFTFDFKNMADGQLHQVKINREEAVVMVEVN 1120
Score = 84.7 bits (208), Expect = 4e-16
Identities = 75/286 (26%), Positives = 123/286 (43%), Gaps = 36/286 (12%)
Query: 27 NFMGCLKEVVYKNNDIRLELSRLARIADTKMKIYGEVVFKCENVATLDPINFETPEAYIS 86
+F GCL+ + Y D+ + LA+ ++ + G V F C T+ P+ F + +Y++
Sbjct: 328 SFHGCLENLYYNGVDV----TELAKKHKPQILMMGNVSFSCPQPQTV-PVTFLSSRSYLA 382
Query: 87 LPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFAVELLDGNLYL 146
LP + + S++F FRT G +LF + R+ + S F + L DG L L
Sbjct: 383 LPGNSGEDKVSVTFQFRTWNRAGHLLFG----ELRRGSGS--------FVLFLKDGKLKL 430
Query: 147 LLDMGSGTIKVKATQKKANDGEWYHVDIQRDGRSGTISVNSRRT--PFTASGESEILDLE 204
L + + NDG+W+ V + V+ P A ++D
Sbjct: 431 SLFQPGQSPRNVTAGAGLNDGQWHSVSFSAKWSHMNVVVDDDTAVQPLVAV----LIDSG 486
Query: 205 GDMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEMQNAAG--- 261
Y GG +N +G + L G+ GC+R + I K + + Q A G
Sbjct: 487 DTYYFGGCLDNSSGSGCKSPLG------GFQGCLRLITIG--DKAVDPILVQQGALGSFR 538
Query: 262 -VKSSCSRMSAKQCDSYPCKNNAVCKDGWNRFICDCTGTGYWGRTC 306
++ ++ + SY C++ C W+ F CDC GTGY G TC
Sbjct: 539 DLQIDSCGITDRCLPSY-CEHGGECSQSWDTFSCDCLGTGYTGETC 583
Score = 75.1 bits (183), Expect = 3e-13
Identities = 61/249 (24%), Positives = 104/249 (41%), Gaps = 43/249 (17%)
Query: 77 NFETPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFA 136
+F T +Y+ P ++ + + F F+TT +G+ + G DF
Sbjct: 796 SFNTETSYLHFPAFHGELTADVCFFFKTTVSSGVFMENLGI--------------TDFIR 841
Query: 137 VEL-LDGNLYLLLDMGSGTIKVKATQKKA-NDGEWYHVDIQRDGRSGTISVNS---RRTP 191
+EL + D+G+G +V ND +W+HV +R+ + ++ V+ + P
Sbjct: 842 IELRAPTEVTFSFDVGNGPCEVTVQSPTPFNDNQWHHVRAERNVKGASLQVDQLPQKMQP 901
Query: 192 FTASGESEILDLEGDMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIR 251
A G L L +++GG TA G++GCIR L ++G + ++
Sbjct: 902 APADGHVR-LQLNSQLFIGG---------------TATRQRGFLGCIRSLQLNGVALDLE 945
Query: 252 QLAEMQNAAGVKSSCSRMSAKQCDSYP--CKNNAVCKDGWNRFICDCTGTGYWGRTCERE 309
+ A + GV+ C A C +Y C+N C++ CDC + Y G C E
Sbjct: 946 ERATV--TPGVEPGC----AGHCSTYGHLCRNGGRCREKRRGVTCDCAFSAYDGPFCSNE 999
Query: 310 ASILSYDGS 318
S GS
Sbjct: 1000 ISAYFATGS 1008
Score = 55.1 bits (131), Expect = 4e-07
Identities = 71/340 (20%), Positives = 122/340 (35%), Gaps = 76/340 (22%)
Query: 98 ISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFAVELLDGNLYLLLDMGSGTIKV 157
IS F+ + NG++L G+ +EL+ G L L+ SG K+
Sbjct: 208 ISLKFKAMQSNGILLHREGQHGNH-------------ITLELIKGKLVFFLN--SGNAKL 252
Query: 158 KATQKKA--------NDGEWYHVDIQRDGRSGTISVNSRRTPFTASGESEILDLEGDMYL 209
+T +D W+ V I+ +V+ F A G+S LDL ++
Sbjct: 253 PSTIAPVTLTLGSLLDDQHWHSVLIELLDTQVNFTVDKHTHHFQAKGDSSYLDLNFEISF 312
Query: 210 GGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEMQNAAGVKSSCSRM 269
GG+P A + GC+ +L+ +G ++ +LA+ +
Sbjct: 313 GGIPTPGRS--------RAFRRKSFHGCLENLYYNG--VDVTELAKKHKPQILMMGNVSF 362
Query: 270 SAKQCDSYPCKNNAVCKDGWNRFICDCTGTGYWGRTCEREASILSYDGSMYMKIIMPMVM 329
S Q + P F+ + G + E + S
Sbjct: 363 SCPQPQTVPV-----------TFLSSRSYLALPGNSGEDKVS------------------ 393
Query: 330 HTEAEDVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLDCIRINCNSSKGP 389
V+F+F + G L+ R + + L L G++KL + + P
Sbjct: 394 ------VTFQFRTWNRAGHLLFGELRRGSGSFVLFLKDGKLKLSL--------FQPGQSP 439
Query: 390 ETLYAGQKLNDNEWHTVRVVRRGKSLKLTVDDDVAEGTMV 429
+ AG LND +WH+V + + + VDDD A +V
Sbjct: 440 RNVTAGAGLNDGQWHSVSFSAKWSHMNVVVDDDTAVQPLV 479
Score = 48.5 bits (114), Expect = 3e-05
Identities = 86/357 (24%), Positives = 128/357 (35%), Gaps = 84/357 (23%)
Query: 391 TLYAGQKLNDNEWHTVRVVRRGKSLKLTVDD--DVAEGTMVGDHTRLEFHN--IETGIMT 446
T+ + NDN+WH VR R K L VD + H RL+ ++ G T
Sbjct: 864 TVQSPTPFNDNQWHHVRAERNVKGASLQVDQLPQKMQPAPADGHVRLQLNSQLFIGGTAT 923
Query: 447 EKRYISVVPSSFIGHLQSLMFNGL-----------------------LYIDLCKNG---- 479
+R F+G ++SL NG+ Y LC+NG
Sbjct: 924 RQR-------GFLGCIRSLQLNGVALDLEERATVTPGVEPGCAGHCSTYGHLCRNGGRCR 976
Query: 480 ---------------DIDYC--ELKARFGLRNIIA----DPVTFKTKSSYL--SLATLQA 516
D +C E+ A F + + + T SS L SL
Sbjct: 977 EKRRGVTCDCAFSAYDGPFCSNEISAYFATGSSMTYHFQEHYTLSENSSSLVSSLHRDVT 1036
Query: 517 YTSMHLFFQFKTTSPDGFILFNSGDGNDFIAVELVKG---YIHYVFDLGNGPNVIKGNSD 573
T + F+TT +L+ S ++++V L I Y D P+ +
Sbjct: 1037 LTREMITLSFRTTRTPSLLLYVSSFYEEYLSVILANNGSLQIRYKLDRHQNPDAFTFDF- 1095
Query: 574 RPLNDNQWHNVVITRDNSNTHSLKVDTKVVTQVI-------NGAKNLDLKGDLYMAGLAQ 626
+ + D Q H V I R+ + ++V+ QVI N K+L L L AG
Sbjct: 1096 KNMADGQLHQVKINREEA-VVMVEVNQSTKKQVILSSGTEFNAVKSLILGKVLEAAG--- 1151
Query: 627 GMYSNLPKLVASRDGFQGCLASVDLNGRLPDLINDALHRSGQIE---RGCEGPSTTC 680
++ A+ GF GCL++V P + AL SG RG P C
Sbjct: 1152 ---ADPDTRRAATSGFTGCLSAVRFGRAAP--LKAALRPSGPSRVTVRGHVAPMARC 1203
Score = 43.1 bits (100), Expect = 0.001
Identities = 34/123 (27%), Positives = 56/123 (45%), Gaps = 6/123 (4%)
Query: 749 FSTTVKDGILVRIDSAPGLGDFLQLHIEQG-KIGVVFNIGTVDISIK-EERTPVNDGKYH 806
F TTV G+ + G+ DF+++ + ++ F++G + + TP ND ++H
Sbjct: 821 FKTTVSSGVFME---NLGITDFIRIELRAPTEVTFSFDVGNGPCEVTVQSPTPFNDNQWH 877
Query: 807 VVRFTRNGGNATLQVDNWPVNEHYPTGRQLTIFNTQAQIAIGG-KDKGRLFQGQLSGLYY 865
VR RN A+LQVD P +Q+ IGG + R F G + L
Sbjct: 878 HVRAERNVKGASLQVDQLPQKMQPAPADGHVRLQLNSQLFIGGTATRQRGFLGCIRSLQL 937
Query: 866 DGL 868
+G+
Sbjct: 938 NGV 940
Score = 35.4 bits (80), Expect = 0.29
Identities = 38/178 (21%), Positives = 71/178 (39%), Gaps = 22/178 (12%)
Query: 743 DRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPV-- 800
D +++ F +GIL+ + G + + L + +GK+ VF + + + + PV
Sbjct: 206 DVISLKFKAMQSNGILLHREGQHG--NHITLELIKGKL--VFFLNSGNAKLPSTIAPVTL 261
Query: 801 ------NDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGRQLTIFNTQAQIAIGGKD--- 851
+D +H V VD H+ + + +I+ GG
Sbjct: 262 TLGSLLDDQHWHSVLIELLDTQVNFTVDKH--THHFQAKGDSSYLDLNFEISFGGIPTPG 319
Query: 852 -----KGRLFQGQLSGLYYDGLKVLNMAAENNPNIKINGSVRLVGEVPSILGTTQTTS 904
+ + F G L LYY+G+ V +A ++ P I + G+V P + T +S
Sbjct: 320 RSRAFRRKSFHGCLENLYYNGVDVTELAKKHKPQILMMGNVSFSCPQPQTVPVTFLSS 377
>gi|239743797 PREDICTED: similar to cell recognition molecule CASPR3
[Homo sapiens]
Length = 944
Score = 110 bits (276), Expect = 5e-24
Identities = 98/342 (28%), Positives = 149/342 (43%), Gaps = 37/342 (10%)
Query: 501 TFKTKSSYLSLATLQAYTSMHLFFQFKTTSPDGFILFNSGDGNDFIAVEL-VKGYIHYVF 559
+F T++SYL + + F FKTT G + N G DFI +EL + + F
Sbjct: 529 SFNTETSYLHFPAFHGELTADVCFFFKTTVSSGVFMENLGI-TDFIRIELRAPTEVTFSF 587
Query: 560 DLGNGPNVIKGNSDRPLNDNQWHNVVITRDNSNTHSLKVD---TKVVTQVINGAKNLDLK 616
D+GNGP + S P NDNQWH+V R N SL+VD K+ +G L L
Sbjct: 588 DVGNGPCEVTVQSPTPFNDNQWHHVRAER-NVKGASLQVDQLPQKMQPAPADGHVRLQLN 646
Query: 617 GDLYMAGLAQGMYSNLPKLVASRDGFQGCLASVDLNGRLPDLINDALHRSGQIERGCEGP 676
L++ G A + GF GC+ S+ LNG DL A G +E GC G
Sbjct: 647 SQLFIGGTA-----------TRQRGFLGCIRSLQLNGVALDLEERATVMPG-VEPGCAGH 694
Query: 677 STTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQCNDPGATYIFGKSGGLILYTWPAND 736
+T C N G C ++ G TCDC+ ++Y G C++ + Y +G + Y + +
Sbjct: 695 CST-YGHLCRNGGRCREKRRGVTCDCAFSAYDGPFCSNEISAYF--ATGSSMTYHFQEHY 751
Query: 737 RPSTRSDRLAVGFS---TTVKDGILV--RIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDI 791
S S L T ++ I + R P L ++ E+ ++ N G++ I
Sbjct: 752 TLSENSSSLVSSLHRDVTLTREMITLSFRTTRTPSLLLYVSSFYEEYLSVILANNGSLQI 811
Query: 792 SIKEER-----------TPVNDGKYHVVRFTRNGGNATLQVD 822
K +R + DG+ H V+ R ++V+
Sbjct: 812 RYKLDRHQNPDAFTFDFKNMADGQLHQVKINREEAVVMVEVN 853
Score = 75.1 bits (183), Expect = 3e-13
Identities = 61/249 (24%), Positives = 104/249 (41%), Gaps = 43/249 (17%)
Query: 77 NFETPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFA 136
+F T +Y+ P ++ + + F F+TT +G+ + G DF
Sbjct: 529 SFNTETSYLHFPAFHGELTADVCFFFKTTVSSGVFMENLGI--------------TDFIR 574
Query: 137 VEL-LDGNLYLLLDMGSGTIKVKATQKKA-NDGEWYHVDIQRDGRSGTISVNS---RRTP 191
+EL + D+G+G +V ND +W+HV +R+ + ++ V+ + P
Sbjct: 575 IELRAPTEVTFSFDVGNGPCEVTVQSPTPFNDNQWHHVRAERNVKGASLQVDQLPQKMQP 634
Query: 192 FTASGESEILDLEGDMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIR 251
A G L L +++GG TA G++GCIR L ++G + ++
Sbjct: 635 APADGHVR-LQLNSQLFIGG---------------TATRQRGFLGCIRSLQLNGVALDLE 678
Query: 252 QLAEMQNAAGVKSSCSRMSAKQCDSYP--CKNNAVCKDGWNRFICDCTGTGYWGRTCERE 309
+ A + GV+ C A C +Y C+N C++ CDC + Y G C E
Sbjct: 679 ERATVM--PGVEPGC----AGHCSTYGHLCRNGGRCREKRRGVTCDCAFSAYDGPFCSNE 732
Query: 310 ASILSYDGS 318
S GS
Sbjct: 733 ISAYFATGS 741
Score = 50.1 bits (118), Expect = 1e-05
Identities = 25/76 (32%), Positives = 36/76 (47%), Gaps = 3/76 (3%)
Query: 641 GFQGCLASVDLNGRLPDLI---NDALHRSGQIERGCEGPSTTCQEDSCANQGVCMQQWEG 697
GFQGCL + + + D I AL ++ G + C C + G C Q W+
Sbjct: 202 GFQGCLRLITIGDKAVDPILVQQGALGSFRDLQIDSCGITDRCLPSYCEHGGECSQSWDT 261
Query: 698 FTCDCSMTSYSGNQCN 713
F+CDC T Y+G C+
Sbjct: 262 FSCDCLGTGYTGETCH 277
Score = 45.4 bits (106), Expect = 3e-04
Identities = 25/78 (32%), Positives = 38/78 (48%), Gaps = 7/78 (8%)
Query: 233 GYVGCIRDLFIDGRSKNIRQLAEMQNAAG----VKSSCSRMSAKQCDSYPCKNNAVCKDG 288
G+ GC+R + I K + + Q A G ++ ++ + SY C++ C
Sbjct: 202 GFQGCLRLITIG--DKAVDPILVQQGALGSFRDLQIDSCGITDRCLPSY-CEHGGECSQS 258
Query: 289 WNRFICDCTGTGYWGRTC 306
W+ F CDC GTGY G TC
Sbjct: 259 WDTFSCDCLGTGYTGETC 276
Score = 43.1 bits (100), Expect = 0.001
Identities = 34/123 (27%), Positives = 56/123 (45%), Gaps = 6/123 (4%)
Query: 749 FSTTVKDGILVRIDSAPGLGDFLQLHIEQG-KIGVVFNIGTVDISIK-EERTPVNDGKYH 806
F TTV G+ + G+ DF+++ + ++ F++G + + TP ND ++H
Sbjct: 554 FKTTVSSGVFME---NLGITDFIRIELRAPTEVTFSFDVGNGPCEVTVQSPTPFNDNQWH 610
Query: 807 VVRFTRNGGNATLQVDNWPVNEHYPTGRQLTIFNTQAQIAIGG-KDKGRLFQGQLSGLYY 865
VR RN A+LQVD P +Q+ IGG + R F G + L
Sbjct: 611 HVRAERNVKGASLQVDQLPQKMQPAPADGHVRLQLNSQLFIGGTATRQRGFLGCIRSLQL 670
Query: 866 DGL 868
+G+
Sbjct: 671 NGV 673
Score = 38.9 bits (89), Expect = 0.026
Identities = 59/258 (22%), Positives = 91/258 (35%), Gaps = 65/258 (25%)
Query: 391 TLYAGQKLNDNEWHTVRVVRRGKSLKLTVDD--DVAEGTMVGDHTRLEFHN--IETGIMT 446
T+ + NDN+WH VR R K L VD + H RL+ ++ G T
Sbjct: 597 TVQSPTPFNDNQWHHVRAERNVKGASLQVDQLPQKMQPAPADGHVRLQLNSQLFIGGTAT 656
Query: 447 EKRYISVVPSSFIGHLQSLMFNGL-----------------------LYIDLCKNG---- 479
+R F+G ++SL NG+ Y LC+NG
Sbjct: 657 RQR-------GFLGCIRSLQLNGVALDLEERATVMPGVEPGCAGHCSTYGHLCRNGGRCR 709
Query: 480 ---------------DIDYC--ELKARFGLRNIIA----DPVTFKTKSSYL--SLATLQA 516
D +C E+ A F + + + T SS L SL
Sbjct: 710 EKRRGVTCDCAFSAYDGPFCSNEISAYFATGSSMTYHFQEHYTLSENSSSLVSSLHRDVT 769
Query: 517 YTSMHLFFQFKTTSPDGFILFNSGDGNDFIAVELVKG---YIHYVFDLGNGPNVIKGNSD 573
T + F+TT +L+ S ++++V L I Y D P+ +
Sbjct: 770 LTREMITLSFRTTRTPSLLLYVSSFYEEYLSVILANNGSLQIRYKLDRHQNPDAFTFDF- 828
Query: 574 RPLNDNQWHNVVITRDNS 591
+ + D Q H V I R+ +
Sbjct: 829 KNMADGQLHQVKINREEA 846
>gi|38788416 laminin, alpha 1 precursor [Homo sapiens]
Length = 3075
Score = 108 bits (269), Expect = 3e-23
Identities = 164/771 (21%), Positives = 302/771 (39%), Gaps = 150/771 (19%)
Query: 88 PKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFAVELLDGNLYLL 147
P+ ++ +++ + +T EP+ L+ + +T DF AVE+ G + L
Sbjct: 2132 PQISSTNYNTLTLNVKTQEPDNLLFYLGS------------STASDFLAVEMRRGRVAFL 2179
Query: 148 LDMGSGTIKVKATQKKANDGEWYHVDIQRDGRSGTISV----NSRRTPFTAS---GESEI 200
D+GSG+ +++ +D W+ + + R G G++SV +++++P S G + +
Sbjct: 2180 WDLGSGSTRLEFPDFPIDDNRWHSIHVARFGNIGSLSVKEMSSNQKSPTKTSKSPGTANV 2239
Query: 201 LDLEGD--MYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEMQN 258
LD+ M++GGL G I + A+ + GC+ + F++G+S + E +
Sbjct: 2240 LDVNNSTLMFVGGL----GGQIKKSP---AVKVTHFKGCLGEAFLNGKSIGLWNYIEREG 2292
Query: 259 AAGVKSSCSRMSAKQCDSYPCKNNAVCKDGWNRFICDCTGTGYWGRTCEREASILSYDGS 318
C+ C G+ + E +DGS
Sbjct: 2293 K-------------------CRG--------------CFGSS------QNEDPSFHFDGS 2313
Query: 319 MYMKIIMPMVMHTEAEDVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLDC 378
Y ++ + + F + GLL+ S + D L +EL GRVK+M +L
Sbjct: 2314 GYS--VVEKSLPATVTQIIMLFNTFSPNGLLLYLGSYGTKDFLSIELFRGRVKVMTDL-- 2369
Query: 379 IRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTVDD-------DVAEGTMVG- 430
GP TL ++ N+ W+ + R K L V D + +G G
Sbjct: 2370 -------GSGPITLLTDRRYNNGTWYKIAFQRNRKQGVLAVIDAYNTSNKETKQGETPGA 2422
Query: 431 --DHTRLEFHNIETGIMTEKRYI--SVVPSSFIGHLQSLMFNGLLYIDLCKNGDIDYCEL 486
D RL+ I G + R + V SF+G +++L + + DL +N
Sbjct: 2423 SSDLNRLDKDPIYVGGLPRSRVVRRGVTTKSFVGCIKNLEISRSTF-DLLRNS------- 2474
Query: 487 KARFGLR-NIIADPVTFKT--KSSYLSLATLQAYTSMHLFFQFKTTSPDGFILF------ 537
+G+R + +P+ + K Y+ L F TT+ G IL
Sbjct: 2475 ---YGVRKGCLLEPIRSVSFLKGGYIELPPKSLSPESEWLVTFATTNSSGIILAALGGDV 2531
Query: 538 -NSGDGND----FIAVELVKGYIHYVFDLGNGPNVIKGNSDRP---LNDNQWHNVVITR- 588
GD + F +V L+ G I + G+G + K P +D Q H++ + R
Sbjct: 2532 EKRGDREEAHVPFFSVMLIGGNIEVHVNPGDGTGLRKALLHAPTGTCSDGQAHSISLVRN 2591
Query: 589 --------DNSNTHSLKVDTKVVTQVINGAKNLDLKGDLYMAGLAQGMYSNLPKLVASRD 640
D +N +K+ T V ++ IN +LY+ G+ +G ++ L+ R
Sbjct: 2592 RRIITVQLDENNPVEMKLGTLVESRTIN-------VSNLYVGGIPEGEGTS---LLTMRR 2641
Query: 641 GFQGCLASVDLNGRLPDLINDALHRSGQIERGCEGPSTTCQEDSCANQGVCMQQWEGFTC 700
F GC+ ++ N L D + H ++ D A + + F
Sbjct: 2642 SFHGCIKNLIFNLELLDFNSAVGHEQVDLDTCWLSERPKLAPD--AEDSKLLPEPRAFPE 2699
Query: 701 DCSMTSYSGNQCNDPGATYIFG--KSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGIL 758
C + + PGA + FG ++ IL P N + + + T G++
Sbjct: 2700 QCVVDAALEYV---PGA-HQFGLTQNSHFIL---PFNQSAVRKKLSVELSIRTFASSGLI 2752
Query: 759 VRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVR 809
+ + D+ L + G++ +F++G + ++DGK+H V+
Sbjct: 2753 YYM-AHQNQADYAVLQLHGGRLHFMFDLGKGRTKVSHPAL-LSDGKWHTVK 2801
Score = 94.4 bits (233), Expect = 5e-19
Identities = 178/816 (21%), Positives = 323/816 (39%), Gaps = 188/816 (23%)
Query: 102 FRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFAVELLDGNLYLLLDMGSGTIKVKATQ 161
F T PNGL+L+ TK DF ++EL G + ++ D+GSG I + T
Sbjct: 2333 FNTFSPNGLLLYL-----------GSYGTK-DFLSIELFRGRVKVMTDLGSGPITL-LTD 2379
Query: 162 KKANDGEWYHVDIQRDGRSGTISV--------NSRRTPFTASGESEILDLEGD-MYLGGL 212
++ N+G WY + QR+ + G ++V + T S++ L+ D +Y+GGL
Sbjct: 2380 RRYNNGTWYKIAFQRNRKQGVLAVIDAYNTSNKETKQGETPGASSDLNRLDKDPIYVGGL 2439
Query: 213 PENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEMQNAAGVKSSCSRMSAK 272
P +R + + +VGCI++L I + ++ ++N+ GV+ K
Sbjct: 2440 PRSRV-------VRRGVTTKSFVGCIKNLEISRSTFDL-----LRNSYGVR--------K 2479
Query: 273 QCDSYPCKNNAVCKDGWNRFICDCTGTGYWGRTCEREASILSYDGSMYMKIIMPMVMHTE 332
C P ++ + K G+ + P + E
Sbjct: 2480 GCLLEPIRSVSFLKGGYIE--------------------------------LPPKSLSPE 2507
Query: 333 AEDVSFRFMSQRAYGLLVATTSRD---SADTLRLELDGGRVKLMVNLDCIRINCNSSKG- 388
+E + F + + G+++A D D + V L+ + +N G
Sbjct: 2508 SEWL-VTFATTNSSGIILAALGGDVEKRGDREEAHVPFFSVMLIGGNIEVHVNPGDGTGL 2566
Query: 389 -PETLYAGQ-KLNDNEWHTVRVVRRGKSLKLTVDD----DVAEGTMVGDHTRLEFHNIET 442
L+A +D + H++ +VR + + + +D+ ++ GT+V T + N+
Sbjct: 2567 RKALLHAPTGTCSDGQAHSISLVRNRRIITVQLDENNPVEMKLGTLVESRT-INVSNLYV 2625
Query: 443 GIMTEKRYISVVPS--SFIGHLQSLMFNGLLYIDLC-----KNGDIDYCELKARFGLR-- 493
G + E S++ SF G +++L+FN L +D + D+D C L R L
Sbjct: 2626 GGIPEGEGTSLLTMRRSFHGCIKNLIFN-LELLDFNSAVGHEQVDLDTCWLSERPKLAPD 2684
Query: 494 ----NIIADPVTFK--------------------TKSSYLSLATLQAYTSMHLFFQF--K 527
++ +P F T++S+ L Q+ L + +
Sbjct: 2685 AEDSKLLPEPRAFPEQCVVDAALEYVPGAHQFGLTQNSHFILPFNQSAVRKKLSVELSIR 2744
Query: 528 TTSPDGFILFNSGDGN-DFIAVELVKGYIHYVFDLGNGPNVIKGNSDRPLNDNQWHNV-- 584
T + G I + + D+ ++L G +H++FDLG G K + L+D +WH V
Sbjct: 2745 TFASSGLIYYMAHQNQADYAVLQLHGGRLHFMFDLGKGRT--KVSHPALLSDGKWHTVKT 2802
Query: 585 -VITRDNSNTHSLKVDTKVVTQVINGAKNLDLKGDLYMAGLAQGMYSNLPKLVASRDGFQ 643
+ R T + ++ +VT V +G LD++G Y+ GL + A + G
Sbjct: 2803 DYVKRKGFITVDGR-ESPMVTVVGDGTM-LDVEGLFYLGGLPS-------QYQARKIG-- 2851
Query: 644 GCLASVDLNGRLPDLINDALHRSGQIERGCEGPSTTCQEDSCANQGVCMQQWEGFTCDCS 703
++ +P I D S Q+++ D
Sbjct: 2852 ------NITHSIPACIGDVTVNSKQLDK-----------------------------DSP 2876
Query: 704 MTSYSGNQCNDPG--ATYIFGKSGGLILYTWPANDRPSTRSD-RLAVGFSTTVKDGILVR 760
+++++ N+C TY G Y + +SD + + F T+ ++G+L+
Sbjct: 2877 VSAFTVNRCYAVAQEGTYFDGSG-----YAALVKEGYKVQSDVNITLEFRTSSQNGVLLG 2931
Query: 761 IDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEE---RTPVNDGKYHVVRFTRNGGNA 817
I +A D + L + GK+ N G I+ E T + DGK+H ++ ++
Sbjct: 2932 ISTAK--VDAIGLELVDGKVLFHVNNGAGRITAAYEPKTATVLCDGKWHTLQANKSKHRI 2989
Query: 818 TLQVDNWPVNEHYPTGRQLTIFNTQAQIAIGGKDKG 853
TL VD V P Q T +T I +GG G
Sbjct: 2990 TLIVDGNAVGAESP-HTQSTSVDTNNPIYVGGYPAG 3024
Score = 93.2 bits (230), Expect = 1e-18
Identities = 156/686 (22%), Positives = 277/686 (40%), Gaps = 112/686 (16%)
Query: 6 DFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDIRLELSRLARIADTKMKIYGEVVF 65
D YVGG P + + + +F+GC+K LE+SR D YG
Sbjct: 2432 DPIYVGGLPRSRVVRRGVTTKSFVGCIK---------NLEISR--STFDLLRNSYG---- 2476
Query: 66 KCENVATLDPINFET--PEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKD 123
L+PI + YI LP + F TT +G+IL G E++
Sbjct: 2477 -VRKGCLLEPIRSVSFLKGGYIELPPKSLSPESEWLVTFATTNSSGIILAALGGDVEKRG 2535
Query: 124 ARSQKNTKVDFFAVELLDGNLYLLLDMGSGT----IKVKATQKKANDGEWYHVDIQRDGR 179
R + + V FF+V L+ GN+ + ++ G GT + A +DG+ + + + R+ R
Sbjct: 2536 DREEAH--VPFFSVMLIGGNIEVHVNPGDGTGLRKALLHAPTGTCSDGQAHSISLVRNRR 2593
Query: 180 SGTISVNSRRTPFTASG---ESEILDLEGDMYLGGLPENRAGLILPTELWTAMLNYGYVG 236
T+ ++ G ES +++ ++Y+GG+PE +L + + G
Sbjct: 2594 IITVQLDENNPVEMKLGTLVESRTINV-SNLYVGGIPEGEGTSLL-------TMRRSFHG 2645
Query: 237 CIRDLFIDGRSKNIRQLAEMQNAAGVK----SSC--SRMSAKQCDSYPCKNNAVCKDGWN 290
CI++L + +L + +A G + +C S D+ K +
Sbjct: 2646 CIKNLIFN------LELLDFNSAVGHEQVDLDTCWLSERPKLAPDAEDSKLLPEPRAFPE 2699
Query: 291 RFICDCT-----GTGYWGRTCEREASILSYDGSMYMKIIMPMVMHTEAEDVSFRFMSQRA 345
+ + D G +G T + IL ++ S K + V + +
Sbjct: 2700 QCVVDAALEYVPGAHQFGLT-QNSHFILPFNQSAVRKKL----------SVELSIRTFAS 2748
Query: 346 YGLLVATTSRDSADTLRLELDGGRVKLMVNLDCIRINCNSSKGPETLYAGQKLNDNEWHT 405
GL+ ++ AD L+L GGR+ M +L KG + L+D +WHT
Sbjct: 2749 SGLIYYMAHQNQADYAVLQLHGGRLHFMFDL---------GKGRTKVSHPALLSDGKWHT 2799
Query: 406 VRVVRRGKSLKLTVDD-DVAEGTMVGDHTRLEFHNIETGIMTEKRYISVVPSSFIGHLQS 464
V+ + +TVD + T+VGD T L+ + Y+ +PS + Q+
Sbjct: 2800 VKTDYVKRKGFITVDGRESPMVTVVGDGTMLDVEGL--------FYLGGLPSQY----QA 2847
Query: 465 LMFNGLLY-IDLC------KNGDIDYCELKARFGLRN--IIADPVTFKTKSSYLSLAT-- 513
+ + I C + +D + F + +A T+ S Y +L
Sbjct: 2848 RKIGNITHSIPACIGDVTVNSKQLDKDSPVSAFTVNRCYAVAQEGTYFDGSGYAALVKEG 2907
Query: 514 LQAYTSMHLFFQFKTTSPDGFILFNSGDGNDFIAVELVKGYIHYVFDLGNGPNVI----K 569
+ + +++ +F+T+S +G +L S D I +ELV G + +F + NG I +
Sbjct: 2908 YKVQSDVNITLEFRTSSQNGVLLGISTAKVDAIGLELVDGKV--LFHVNNGAGRITAAYE 2965
Query: 570 GNSDRPLNDNQWHNVVITRDNSNTH--SLKVDTKVV--TQVINGAKNLDLKGDLYMAGLA 625
+ L D +WH + + N + H +L VD V + ++D +Y+ G
Sbjct: 2966 PKTATVLCDGKWHTL---QANKSKHRITLIVDGNAVGAESPHTQSTSVDTNNPIYVGGYP 3022
Query: 626 QGMYSNLPKLVASRDGFQGCLASVDL 651
G+ K + S+ F+GCL + L
Sbjct: 3023 AGVKQ---KCLRSQTSFRGCLRKLAL 3045
Score = 75.5 bits (184), Expect = 3e-13
Identities = 82/311 (26%), Positives = 140/311 (45%), Gaps = 60/311 (19%)
Query: 522 LFFQFKTTSPDGFILF-NSGDGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSDRPLNDNQ 580
L KT PD + + S +DF+AVE+ +G + +++DLG+G ++ D P++DN+
Sbjct: 2142 LTLNVKTQEPDNLLFYLGSSTASDFLAVEMRRGRVAFLWDLGSGSTRLEF-PDFPIDDNR 2200
Query: 581 WHNVVITRDNSNTHSLKVD-------TKVVTQVINGAKN-LDLKGD--LYMAGLAQGMYS 630
WH++ + R N SL V + T G N LD+ +++ GL G
Sbjct: 2201 WHSIHVARFG-NIGSLSVKEMSSNQKSPTKTSKSPGTANVLDVNNSTLMFVGGLG-GQIK 2258
Query: 631 NLPKLVASRDGFQGCLASVDLNGRLPDLINDALHRSGQIERGCEGPSTTCQEDSCANQGV 690
P + + F+GCL LNG+ L N + R G+ RGC G S
Sbjct: 2259 KSPAVKVTH--FKGCLGEAFLNGKSIGLWN-YIEREGKC-RGCFGSS------------- 2301
Query: 691 CMQQWEGFTCDCSMTSYSGNQCNDPGATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFS 750
Q DP ++ F SG Y+ P+T + + + F+
Sbjct: 2302 --------------------QNEDP--SFHFDGSG----YSVVEKSLPATVTQIIML-FN 2334
Query: 751 TTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRF 810
T +G+L+ + S G DFL + + +G++ V+ ++G+ I++ +R N+G ++ + F
Sbjct: 2335 TFSPNGLLLYLGSY-GTKDFLSIELFRGRVKVMTDLGSGPITLLTDRR-YNNGTWYKIAF 2392
Query: 811 TRNGGNATLQV 821
RN L V
Sbjct: 2393 QRNRKQGVLAV 2403
Score = 65.9 bits (159), Expect = 2e-10
Identities = 84/379 (22%), Positives = 147/379 (38%), Gaps = 50/379 (13%)
Query: 321 MKIIMPMVMHTEAEDVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLDCIR 380
++ P + T ++ +Q LL S ++D L +E+ GRV + +L
Sbjct: 2127 IRAYQPQISSTNYNTLTLNVKTQEPDNLLFYLGSSTASDFLAVEMRRGRVAFLWDL---- 2182
Query: 381 INCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTVDD-------DVAEGTMVGDHT 433
S + ++DN WH++ V R G L+V + G
Sbjct: 2183 ----GSGSTRLEFPDFPIDDNRWHSIHVARFGNIGSLSVKEMSSNQKSPTKTSKSPGTAN 2238
Query: 434 RLEFHNIETGIM-----TEKRYISVVPSSFIGHLQSLMFNGL---LYIDLCKNGDIDYCE 485
L+ +N + K+ +V + F G L NG L+ + + G C
Sbjct: 2239 VLDVNNSTLMFVGGLGGQIKKSPAVKVTHFKGCLGEAFLNGKSIGLWNYIEREGKCRGC- 2297
Query: 486 LKARFGLRNIIADPVTFKTKSSYLSLATLQAYTSMHLFFQFKTTSPDGFILFNSGDG-ND 544
FG + DP S Y + T + F T SP+G +L+ G D
Sbjct: 2298 ----FG-SSQNEDPSFHFDGSGYSVVEKSLPATVTQIIMLFNTFSPNGLLLYLGSYGTKD 2352
Query: 545 FIAVELVKGYIHYVFDLGNGPNVIKGNSDRPLNDNQWHNVVITR----------DNSNTH 594
F+++EL +G + + DLG+GP + +DR N+ W+ + R D NT
Sbjct: 2353 FLSIELFRGRVKVMTDLGSGPITLL--TDRRYNNGTWYKIAFQRNRKQGVLAVIDAYNTS 2410
Query: 595 SLKVDTKVVTQVINGAKNLDLKGDLYMAGLAQGMYSNLPKLVASRDGFQGCLASVDLNGR 654
+ + + LD K +Y+ GL + S + + + F GC+ +++++
Sbjct: 2411 NKETKQGETPGASSDLNRLD-KDPIYVGGLPR---SRVVRRGVTTKSFVGCIKNLEISRS 2466
Query: 655 LPDLINDALHRSGQIERGC 673
DL L S + +GC
Sbjct: 2467 TFDL----LRNSYGVRKGC 2481
Score = 48.1 bits (113), Expect = 4e-05
Identities = 56/251 (22%), Positives = 97/251 (38%), Gaps = 46/251 (18%)
Query: 1 MLGSDDFFYVGGSPSTADLPG-SPVSNNFMGCLKEVVYKNNDIRLELSRLARIADTKMKI 59
ML + FY+GG PS ++++ C+ +V + + D +
Sbjct: 2829 MLDVEGLFYLGGLPSQYQARKIGNITHSIPACIGDVTVNSKQL-----------DKDSPV 2877
Query: 60 YGEVVFKCENVATLDPINFETPEAYISLPKWNTKRMG--SISFDFRTTEPNGLILFTHGK 117
V +C VA + Y +L K K +I+ +FRT+ NG++L
Sbjct: 2878 SAFTVNRCYAVAQEG--TYFDGSGYAALVKEGYKVQSDVNITLEFRTSSQNGVLL----- 2930
Query: 118 PQERKDARSQKNTKVDFFAVELLDGNLYLLLDMGSGTIKVKATQKKAN---DGEWYHVDI 174
KVD +EL+DG + ++ G+G I K A DG+W+ +
Sbjct: 2931 --------GISTAKVDAIGLELVDGKVLFHVNNGAGRITAAYEPKTATVLCDGKWHTLQA 2982
Query: 175 QRDGRSGTISVNSR----RTPFTASGESEILDLEGDMYLGGLPENRAGLILPTELWTAML 230
+ T+ V+ +P T +S +D +Y+GG P L ++
Sbjct: 2983 NKSKHRITLIVDGNAVGAESPHT---QSTSVDTNNPIYVGGYPAGVKQKCLRSQT----- 3034
Query: 231 NYGYVGCIRDL 241
+ GC+R L
Sbjct: 3035 --SFRGCLRKL 3043
Score = 42.7 bits (99), Expect = 0.002
Identities = 22/94 (23%), Positives = 46/94 (48%), Gaps = 1/94 (1%)
Query: 739 STRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERT 798
ST + L + T D +L + S+ DFL + + +G++ ++++G+ ++
Sbjct: 2136 STNYNTLTLNVKTQEPDNLLFYLGSSTA-SDFLAVEMRRGRVAFLWDLGSGSTRLEFPDF 2194
Query: 799 PVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPT 832
P++D ++H + R G +L V N+ PT
Sbjct: 2195 PIDDNRWHSIHVARFGNIGSLSVKEMSSNQKSPT 2228
>gi|54873613 agrin [Homo sapiens]
Length = 2045
Score = 103 bits (257), Expect = 9e-22
Identities = 165/711 (23%), Positives = 285/711 (40%), Gaps = 156/711 (21%)
Query: 67 CENVATLDPINFETPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKDARS 126
CE V FE ++++ P ++ +FR EP GL+L+ +AR
Sbjct: 1366 CEKVLGAPVPAFEG-RSFLAFPTLRAYHTLRLALEFRALEPQGLLLYNG-------NARG 1417
Query: 127 QKNTKVDFFAVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQRDGRSGTISVN 186
+ DF A+ LLDG + L D GSG V + G+W+ +++ R R GT+SV+
Sbjct: 1418 K-----DFLALALLDGRVQLRFDTGSGPA-VLTSAVPVEPGQWHRLELSRHWRRGTLSVD 1471
Query: 187 SRRTPFTASGES--EILDLEGDMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFID 244
TP S + L+L+ D+++GG+PE++A + L + G GCIR L ++
Sbjct: 1472 GE-TPVLGESPSGTDGLNLDTDLFVGGVPEDQAAVALER----TFVGAGLRGCIRLLDVN 1526
Query: 245 G-------------RSKNIRQLAE---MQNAAGVKSSCSRMSAKQ--------------- 273
R + + + + N + C + A +
Sbjct: 1527 NQRLELGIGPGAATRGSGVGECGDHPCLPNPCHGGAPCQNLEAGRFHCQCPPGRVGPTCA 1586
Query: 274 -----CDSYPCKNNAVCK---DGWNRFICDCTGTGYWGRTCEREAS-------ILSYDGS 318
C PC A C+ +G + C+C G G C+ + + ++G
Sbjct: 1587 DEKSPCQPNPCHGAAPCRVLPEGGAQ--CECP-LGREGTFCQTASGQDGSGPFLADFNGF 1643
Query: 319 MYMKIIMPMVMHTEAEDVSFR------FMSQRAYGLLVATTSRDSA--DTLRLELDGGRV 370
++++ +HT A D+ + F+++ GLL+ + D + L L R+
Sbjct: 1644 SHLEL---RGLHTFARDLGEKMALEVVFLARGPSGLLLYNGQKTDGKGDFVSLALRDRRL 1700
Query: 371 KLMVNLDCIRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTVDD--------- 421
+ +L KG + + + + W V + R G+ L V D
Sbjct: 1701 EFRYDL---------GKGAAVIRSREPVTLGAWTRVSLERNGRKGALRVGDGPRVLGESP 1751
Query: 422 ------DVAEGTMVG---DHTRLE------------FHNIETG---IMTEKRYISVVP-S 456
++ E VG D ++L + G ++T + + V +
Sbjct: 1752 VPHTVLNLKEPLYVGGAPDFSKLARAAAVSSGFDGAIQLVSLGGRQLLTPEHVLRQVDVT 1811
Query: 457 SFIGHL------------QSLMFNGLLYIDLCKNG-DIDYCEL----KARFGLRNIIADP 499
SF GH S + Y+ LC G +CE K+ + + D
Sbjct: 1812 SFAGHPCTRASGHPCLNGASCVPREAAYVCLCPGGFSGPHCEKGLVEKSAGDVDTLAFDG 1871
Query: 500 VTFKTKSSYLSLATL--QAYTSMHLFFQFKTTSPDGFILFN--SGDGNDFIAVELVKGYI 555
TF YL+ T +A S H +T + G +L++ + + D++A+ +V G++
Sbjct: 1872 RTFV---EYLNAVTESEKALQSNHFELSLRTEATQGLVLWSGKATERADYVALAIVDGHL 1928
Query: 556 HYVFDLGNGPNVIKGNSDRPLNDNQWHNVVITRDNSNTHSLKV--DTKVVTQVINGAKNL 613
++LG+ P V++ S P+N N+W VV R+ SL+V + V GA L
Sbjct: 1929 QLSYNLGSQPVVLR--STVPVNTNRWLRVVAHRE-QREGSLQVGNEAPVTGSSPLGATQL 1985
Query: 614 DLKGDLYMAGLAQ-GMYSNLPKLVASRDGFQGCLASVDLNGRLPDLINDAL 663
D G L++ GL + + LPK A GF GCL V + L+ DA+
Sbjct: 1986 DTDGALWLGGLPELPVGPALPK--AYGTGFVGCLRDVVVGRHPLHLLEDAV 2034
Score = 91.3 bits (225), Expect = 4e-18
Identities = 98/427 (22%), Positives = 172/427 (40%), Gaps = 63/427 (14%)
Query: 495 IIADPVTFKTKSSYLSLATLQAYTSMHLFFQFKTTSPDGFILFN-SGDGNDFIAVELVKG 553
++ PV S+L+ TL+AY ++ L +F+ P G +L+N + G DF+A+ L+ G
Sbjct: 1369 VLGAPVPAFEGRSFLAFPTLRAYHTLRLALEFRALEPQGLLLYNGNARGKDFLALALLDG 1428
Query: 554 YIHYVFDLGNGPNVIKGNSDRPLNDNQWHNVVITRD-NSNTHSLKVDTKVVTQVINGAKN 612
+ FD G+GP V+ S P+ QWH + ++R T S+ +T V+ + +G
Sbjct: 1429 RVQLRFDTGSGPAVL--TSAVPVEPGQWHRLELSRHWRRGTLSVDGETPVLGESPSGTDG 1486
Query: 613 LDLKGDLYMAGLAQGMYSNLPKLVASRDGFQGCLASVDLNGRLPDL-------------- 658
L+L DL++ G+ + + + G +GC+ +D+N + +L
Sbjct: 1487 LNLDTDLFVGGVPEDQAAVALERTFVGAGLRGCIRLLDVNNQRLELGIGPGAATRGSGVG 1546
Query: 659 -------INDALHRS-----------------GQIERGCEGPSTTCQEDSCANQGVCMQQ 694
+ + H G++ C + CQ + C C
Sbjct: 1547 ECGDHPCLPNPCHGGAPCQNLEAGRFHCQCPPGRVGPTCADEKSPCQPNPCHGAAPCRVL 1606
Query: 695 WE-GFTCDCSM-------TSYSGNQCNDPGATYIFGKS----GGLILYTWPANDRPSTRS 742
E G C+C + + SG + P G S GL + ++ +
Sbjct: 1607 PEGGAQCECPLGREGTFCQTASGQDGSGPFLADFNGFSHLELRGLHTFARDLGEKMALEV 1666
Query: 743 DRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVND 802
LA G S +L G GDF+ L + ++ +++G ++ R PV
Sbjct: 1667 VFLARGPSGL----LLYNGQKTDGKGDFVSLALRDRRLEFRYDLGK-GAAVIRSREPVTL 1721
Query: 803 GKYHVVRFTRNGGNATLQVDNWP-VNEHYPTGRQLTIFNTQAQIAIGG-KDKGRLFQGQL 860
G + V RNG L+V + P V P T+ N + + +GG D +L +
Sbjct: 1722 GAWTRVSLERNGRKGALRVGDGPRVLGESPVPH--TVLNLKEPLYVGGAPDFSKLARAAA 1779
Query: 861 SGLYYDG 867
+DG
Sbjct: 1780 VSSGFDG 1786
Score = 72.8 bits (177), Expect = 2e-12
Identities = 89/363 (24%), Positives = 147/363 (40%), Gaps = 31/363 (8%)
Query: 507 SYLSLATLQAYT-----SMHLFFQFKTTSPDGFILFNSG--DGN-DFIAVELVKGYIHYV 558
S+L L L + M L F P G +L+N DG DF+++ L + +
Sbjct: 1644 SHLELRGLHTFARDLGEKMALEVVFLARGPSGLLLYNGQKTDGKGDFVSLALRDRRLEFR 1703
Query: 559 FDLGNGPNVIKGNSDRPLNDNQWHNVVITRDNSNTHSLKVDT--KVVTQVINGAKNLDLK 616
+DLG G VI+ S P+ W V + R N +L+V +V+ + L+LK
Sbjct: 1704 YDLGKGAAVIR--SREPVTLGAWTRVSLER-NGRKGALRVGDGPRVLGESPVPHTVLNLK 1760
Query: 617 GDLYMAGLAQGMYSNLPKLVASRDGFQGCLASVDLNGRLPDLINDALHRSGQIERGCEGP 676
LY+ G +S L + A GF G + V L GR L + + R + P
Sbjct: 1761 EPLYVGGAPD--FSKLARAAAVSSGFDGAIQLVSLGGR-QLLTPEHVLRQVDVTSFAGHP 1817
Query: 677 STTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQC---------NDPGATYIFGKSGGL 727
T C N C+ + + C C +SG C D G++
Sbjct: 1818 CTRASGHPCLNGASCVPREAAYVCLCP-GGFSGPHCEKGLVEKSAGDVDTLAFDGRTFVE 1876
Query: 728 ILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIG 787
L +++ + +S+ + T G+++ A D++ L I G + + +N+G
Sbjct: 1877 YLNAVTESEK-ALQSNHFELSLRTEATQGLVLWSGKATERADYVALAIVDGHLQLSYNLG 1935
Query: 788 TVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDN-WPVNEHYPTGRQLTIFNTQAQIA 846
+ + ++ PVN ++ V R +LQV N PV P G T +T +
Sbjct: 1936 SQPVVLR-STVPVNTNRWLRVVAHREQREGSLQVGNEAPVTGSSPLG--ATQLDTDGALW 1992
Query: 847 IGG 849
+GG
Sbjct: 1993 LGG 1995
Score = 54.3 bits (129), Expect = 6e-07
Identities = 43/167 (25%), Positives = 70/167 (41%), Gaps = 18/167 (10%)
Query: 261 GVKSSCSRMSAKQCDSYPCKNNAVCKDGW---NRFICDCTGTGYWGRTCER--EASILSY 315
G + + K CDS PC + C+D W F C C G G CE+ A + ++
Sbjct: 1320 GRRPPAPQQPPKPCDSQPCFHGGTCQD-WALGGGFTCSCP-AGRGGAVCEKVLGAPVPAF 1377
Query: 316 DGSMYMKIIMPMVMHTEAEDVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVN 375
+G ++ HT + FR + + GLL+ + D L L L GRV+L
Sbjct: 1378 EGRSFLAFPTLRAYHTLRLALEFRALEPQ--GLLLYNGNARGKDFLALALLDGRVQL--- 1432
Query: 376 LDCIRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTVDDD 422
++ GP L + + +WH + + R + L+VD +
Sbjct: 1433 ------RFDTGSGPAVLTSAVPVEPGQWHRLELSRHWRRGTLSVDGE 1473
Score = 46.6 bits (109), Expect = 1e-04
Identities = 49/178 (27%), Positives = 72/178 (40%), Gaps = 13/178 (7%)
Query: 676 PSTTCQEDSCANQGVCMQQWE---GFTCDCSMTSYSGNQCNDPGATYIFGKSGGLILYTW 732
P C C + G C Q W GFTC C G C + G L +
Sbjct: 1329 PPKPCDSQPCFHGGTC-QDWALGGGFTCSCP-AGRGGAVCEKVLGAPVPAFEGRSFL-AF 1385
Query: 733 PANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDIS 792
P T RLA+ F G+L+ +A G DFL L + G++ + F+ G+ +
Sbjct: 1386 PTLRAYHTL--RLALEFRALEPQGLLLYNGNARGK-DFLALALLDGRVQLRFDTGSGP-A 1441
Query: 793 IKEERTPVNDGKYHVVRFTRNGGNATLQVD-NWPVNEHYPTGRQLTIFNTQAQIAIGG 849
+ PV G++H + +R+ TL VD PV P+G N + +GG
Sbjct: 1442 VLTSAVPVEPGQWHRLELSRHWRRGTLSVDGETPVLGESPSGTD--GLNLDTDLFVGG 1497
>gi|33469935 EGF-like, fibronectin type III and laminin G domains
isoform 3 [Homo sapiens]
Length = 375
Score = 100 bits (248), Expect = 9e-21
Identities = 91/343 (26%), Positives = 155/343 (45%), Gaps = 30/343 (8%)
Query: 520 MHLFFQFKTTSPDGFILFNSGDGN-DFIAVELVKGYIHYVFDLGNGPNVIKGNSDRPLND 578
M F+ S DG +L++ G+ DF+++ L G++ + FD G+G V++ S+ PL
Sbjct: 1 MEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLR--SEDPLTL 58
Query: 579 NQWHNVVITRDNSNTHSLKVDTKVVTQVI--NGAKNLDLKGDLYMAGLAQGMYSNLPKLV 636
WH + ++R N L+VD + + + + G + D+++ G+ Y ++ K
Sbjct: 59 GNWHELRVSRTAKNG-ILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPN--YDDVKKNS 115
Query: 637 ASRDGFQGCLASVDLNGRLPDLINDALHRSGQIERGCEGPSTTCQEDSCANQGVCMQQWE 696
F G + + LN R + +D SG E + C CA+ G C + E
Sbjct: 116 GVLKPFSGSIQKIILNDRTIHVKHD--FTSGV---NVENAAHPCVRAPCAHGGSCRPRKE 170
Query: 697 GFTCDCSMTSYSGNQCNDPGATYI-----FGKSGGLILYTWP-ANDRPSTRSDRLAVGFS 750
G+ CDC + + G C I G+S + Y P R S + + F
Sbjct: 171 GYDCDCPL-GFEGLHCQKAIIEAIEIPQFIGRS--YLTYDNPDILKRVSGSRSNVFMRFK 227
Query: 751 TTVKDGILVRIDSAP--GLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVV 808
TT KDG+L+ +P DF+ L + G + +N+G+ SI + NDG++H V
Sbjct: 228 TTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGS-FNDGRWHRV 286
Query: 809 RFTRNGGNATLQVDNWPVNEHYPTG--RQLTIFNTQAQIAIGG 849
+ R+G + + VD++ G RQL N + +GG
Sbjct: 287 KAVRDGQSGKITVDDYGARTGKSPGMMRQL---NINGALYVGG 326
Score = 81.6 bits (200), Expect = 3e-15
Identities = 76/336 (22%), Positives = 145/336 (43%), Gaps = 57/336 (16%)
Query: 102 FRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFAVELLDGNLYLLLDMGSGTIKVKATQ 161
FR +G++L+++ D S+ DF ++ L G++ D GSGT V ++
Sbjct: 7 FRPDSGDGVLLYSY-------DTGSK-----DFLSINLAGGHVEFRFDCGSGT-GVLRSE 53
Query: 162 KKANDGEWYHVDIQRDGRSGTISVNSRR-TPFTASGESEILDLEGDMYLGGLP-----EN 215
G W+ + + R ++G + V+ ++ A G + D+++GG+P +
Sbjct: 54 DPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKK 113
Query: 216 RAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEMQNAAGVKSSCSRMSAKQCD 275
+G++ P + G I+ + ++ R+ +++ + + V+++ A C
Sbjct: 114 NSGVLKP-----------FSGSIQKIILNDRTIHVKH--DFTSGVNVENA-----AHPCV 155
Query: 276 SYPCKNNAVCKDGWNRFICDCTGTGYWGRTCEREA----SILSYDGSMYMKIIMPMVMHT 331
PC + C+ + CDC G+ G C++ I + G Y+ P ++
Sbjct: 156 RAPCAHGGSCRPRKEGYDCDCP-LGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKR 214
Query: 332 EA---EDVSFRFMSQRAYGLLV---ATTSRDSADTLRLELDGGRVKLMVNLDCIRINCNS 385
+ +V RF + GLL+ + R ++D + L L G + NL
Sbjct: 215 VSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNL--------- 265
Query: 386 SKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTVDD 421
G ++ ND WH V+ VR G+S K+TVDD
Sbjct: 266 GSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDD 301
>gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo
sapiens]
Length = 3312
Score = 91.7 bits (226), Expect = 3e-18
Identities = 83/341 (24%), Positives = 140/341 (41%), Gaps = 48/341 (14%)
Query: 506 SSYLSLATLQAYTSMHLFFQFKTTSPDGFILFNS--GDGNDFIAVELVKGYIHYVFDLGN 563
SS++ L+ + L F T G + +N + +DF+A+ELV G + + G
Sbjct: 1523 SSFVMFRGLRQRFHLTLSLSFATVQQSGLLFYNGRLNEKHDFLALELVAGQVRLTYSTGE 1582
Query: 564 GPNVIKGNSDRPLNDNQWHNVVITRDNS-NTHSL---------KV------DTKVVTQVI 607
V+ L+D QWH V + N T +L KV D V +
Sbjct: 1583 SNTVVSPTVPGGLSDGQWHTVHLRYYNKPRTDALGGAQGPSKDKVAVLSVDDCDVAVALQ 1642
Query: 608 NGA-----------------KNLDLKGDLYMAGLAQGMYSNLPK-LVASRDGFQGCLASV 649
GA K+LDL G L + G+ NLP+ S F GC+ +
Sbjct: 1643 FGAEIGNYSCAAAGVQTSSKKSLDLTGPLLLGGVP-----NLPENFPVSHKDFIGCMRDL 1697
Query: 650 DLNGRLPDLINDALHRSGQIERGCEGPSTTCQEDSCANQGVCMQQWEGFTCDCSMTSYSG 709
++GR D+ A + GC+ C C N G C ++W F+CDC + + G
Sbjct: 1698 HIDGRRVDMA--AFVANNGTMAGCQAKLHFCDSGPCKNSGFCSERWGSFSCDCPV-GFGG 1754
Query: 710 NQCNDPGATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGD 769
C A + G + + + +D + L + F T G+L+++ + P
Sbjct: 1755 KDCQLTMAHPHHFRGNGTLSWNF-GSDMAVSVPWYLGLAFRTRATQGVLMQVQAGP--HS 1811
Query: 770 FLQLHIEQGKIGVVFNIGTVDIS-IKEERTPVNDGKYHVVR 809
L +++G + V G+ S + ++ V+DG++H +R
Sbjct: 1812 TLLCQLDRGLLSVTVTRGSGRASHLLLDQVTVSDGRWHDLR 1852
Score = 84.7 bits (208), Expect = 4e-16
Identities = 93/414 (22%), Positives = 160/414 (38%), Gaps = 95/414 (22%)
Query: 66 KCENVATLDPINFETPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKDAR 125
+CE A P P +++ + ++S F T + +GL+ +
Sbjct: 1512 RCEVAARSFP-----PSSFVMFRGLRQRFHLTLSLSFATVQQSGLLFYN----------- 1555
Query: 126 SQKNTKVDFFAVELLDGNLYLLLDMG-SGTIKVKATQKKANDGEWYHVDIQRDGRSGTIS 184
+ N K DF A+EL+ G + L G S T+ +DG+W+ V ++ + T +
Sbjct: 1556 GRLNEKHDFLALELVAGQVRLTYSTGESNTVVSPTVPGGLSDGQWHTVHLRYYNKPRTDA 1615
Query: 185 VNSRRTPF---------------------------------TASGESEILDLEGDMYLGG 211
+ + P + + LDL G + LGG
Sbjct: 1616 LGGAQGPSKDKVAVLSVDDCDVAVALQFGAEIGNYSCAAAGVQTSSKKSLDLTGPLLLGG 1675
Query: 212 LPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEMQNAAGVKSSCSRMSA 271
+P LP + + ++GC+RDL IDGR + +A G + C +
Sbjct: 1676 VPN------LPENF--PVSHKDFIGCMRDLHIDGRRVD---MAAFVANNGTMAGC-QAKL 1723
Query: 272 KQCDSYPCKNNAVCKDGWNRFICDCTGTGYWGRTCE---------REASILSYDGSMYMK 322
CDS PCKN+ C + W F CDC G+ G+ C+ R LS++ M
Sbjct: 1724 HFCDSGPCKNSGFCSERWGSFSCDCP-VGFGGKDCQLTMAHPHHFRGNGTLSWNFGSDMA 1782
Query: 323 IIMPMVMHTEAEDVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLDCIRIN 382
+ +P + F ++ G+L+ + + TL +LD G L + +
Sbjct: 1783 VSVPWYL-------GLAFRTRATQGVLMQVQAGPHS-TLLCQLDRG-------LLSVTVT 1827
Query: 383 CNSSKGPETLYAGQKLNDNEWHTVRVV-------RRGKS-LKLTVDDDVAEGTM 428
S + L ++D WH +R+ RRG L +++D + + TM
Sbjct: 1828 RGSGRASHLLLDQVTVSDGRWHDLRLELQEEPGGRRGHHVLMVSLDFSLFQDTM 1881
Score = 48.9 bits (115), Expect = 3e-05
Identities = 115/533 (21%), Positives = 178/533 (33%), Gaps = 114/533 (21%)
Query: 271 AKQCDSYPCKNNAVCKDGWNR-FICDC-TGTGYWGRTCEREASILSYDGSMYMKIIMPMV 328
A +C C+N C D N F C C G + G CE A + + +
Sbjct: 1476 AGRCVPGVCRNGGTCTDAPNGGFRCQCPAGGAFEGPRCEVAARSFPPSSFVMFRGLRQRF 1535
Query: 329 MHTEAEDVSFRFMSQRAYGLLVATTS-RDSADTLRLELDGGRVKLMVNLDCIRINCNSSK 387
T +S F + + GLL + D L LEL G+V+L + N+
Sbjct: 1536 HLT----LSLSFATVQQSGLLFYNGRLNEKHDFLALELVAGQVRLTYSTG----ESNTVV 1587
Query: 388 GPETLYAGQKLNDNEWHTVRV----------------VRRGKSLKLTVDD-DVAEGTMVG 430
P T+ G L+D +WHTV + + K L+VDD DVA G
Sbjct: 1588 SP-TVPGG--LSDGQWHTVHLRYYNKPRTDALGGAQGPSKDKVAVLSVDDCDVAVALQFG 1644
Query: 431 DHTRLEFHNIETGIMTEKR---------YISVVPS----------SFIGHLQSLMFNGL- 470
+ G+ T + + VP+ FIG ++ L +G
Sbjct: 1645 AEIG-NYSCAAAGVQTSSKKSLDLTGPLLLGGVPNLPENFPVSHKDFIGCMRDLHIDGRR 1703
Query: 471 --LYIDLCKNGDIDYCELKARFGLRNIIAD---------------PVTFKTKSSYLSLA- 512
+ + NG + C+ K F + PV F K L++A
Sbjct: 1704 VDMAAFVANNGTMAGCQAKLHFCDSGPCKNSGFCSERWGSFSCDCPVGFGGKDCQLTMAH 1763
Query: 513 ----------------TLQAYTSMHLFFQFKTTSPDGFILFNSGDGNDFIAVELVKGYIH 556
+ +L F+T + G ++ + + +L +G +
Sbjct: 1764 PHHFRGNGTLSWNFGSDMAVSVPWYLGLAFRTRATQGVLMQVQAGPHSTLLCQLDRGLLS 1823
Query: 557 YVFDLGNGPNVIKGNSDRPLNDNQWHNVVITRDN-------------SNTHSLKVDTKVV 603
G+G ++D +WH++ + S SL DT V
Sbjct: 1824 VTVTRGSGRASHLLLDQVTVSDGRWHDLRLELQEEPGGRRGHHVLMVSLDFSLFQDTMAV 1883
Query: 604 TQVINGAKNLDLKGDLYMAGLAQGMYSNLPKLVASRDGFQGCLASVDLNGRLPDLINDAL 663
+ G K L++ GL G P+ G GC+ V L G P L
Sbjct: 1884 GSELQGLK----VKQLHVGGLPPGSAEEAPQ------GLVGCIQGVWL-GSTPSGSPALL 1932
Query: 664 HRSGQI--ERGCEGPSTTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQCND 714
S ++ E GC + C C C W+ F+C C Y G C D
Sbjct: 1933 PPSHRVNAEPGCV-VTNACASGPCPPHADCRDLWQTFSCTC-QPGYYGPGCVD 1983
Score = 48.5 bits (114), Expect = 3e-05
Identities = 46/175 (26%), Positives = 74/175 (42%), Gaps = 23/175 (13%)
Query: 142 GNLYLLLDMGSGTIK-VKATQKKANDGEWY--HVDIQRD--GRSG----TISVNSRRTPF 192
G L + + GSG + Q +DG W+ +++Q + GR G +S++
Sbjct: 1820 GLLSVTVTRGSGRASHLLLDQVTVSDGRWHDLRLELQEEPGGRRGHHVLMVSLDFSLFQD 1879
Query: 193 TASGESEILDLE-GDMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIR 251
T + SE+ L+ +++GGLP A G VGCI+ +++
Sbjct: 1880 TMAVGSELQGLKVKQLHVGGLPPGSA----------EEAPQGLVGCIQGVWLGSTPSGSP 1929
Query: 252 QLAEMQNAAGVKSSCSRMSAKQCDSYPCKNNAVCKDGWNRFICDCTGTGYWGRTC 306
L + + C +A C S PC +A C+D W F C C GY+G C
Sbjct: 1930 ALLPPSHRVNAEPGCVVTNA--CASGPCPPHADCRDLWQTFSCTCQ-PGYYGPGC 1981
Score = 36.2 bits (82), Expect = 0.17
Identities = 35/173 (20%), Positives = 65/173 (37%), Gaps = 38/173 (21%)
Query: 673 CEGPSTTCQEDSCANQGVCMQQWEGFTC---------DCSMTSYSGN------------- 710
CE C + C N G C ++ G+TC DC + + +G
Sbjct: 1432 CETELDLCYSNPCRNGGACARREGGYTCVCRPRFTGEDCELDTEAGRCVPGVCRNGGTCT 1491
Query: 711 -------QCNDPGATYIFGKSGGLILYTWPANDRPSTRSDR------LAVGFSTTVKDGI 757
+C P G + ++P + R R L++ F+T + G+
Sbjct: 1492 DAPNGGFRCQCPAGGAFEGPRCEVAARSFPPSSFVMFRGLRQRFHLTLSLSFATVQQSGL 1551
Query: 758 LVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTP--VNDGKYHVV 808
L DFL L + G++ + ++ G + ++ P ++DG++H V
Sbjct: 1552 LFYNGRLNEKHDFLALELVAGQVRLTYSTGESN-TVVSPTVPGGLSDGQWHTV 1603
>gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo
sapiens]
Length = 2923
Score = 89.4 bits (220), Expect = 2e-17
Identities = 87/372 (23%), Positives = 152/372 (40%), Gaps = 67/372 (18%)
Query: 476 CKNGDID--YCELKARFGLRNIIADPVTFKTKSSYLSLATLQAYTSMHLFFQFKTTSPDG 533
C +GD + YC++ R +F S +++ L+ L F T DG
Sbjct: 1355 CPSGDFEKPYCQVTTR-----------SFPAHS-FITFRGLRQRFHFTLALSFATKERDG 1402
Query: 534 FILFNS--GDGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSDRPLNDNQWHNV------- 584
+L+N + +DF+A+E+++ + F G + ++D QWH V
Sbjct: 1403 LLLYNGRFNEKHDFVALEVIQEQVQLTFSAGESTTTVSPFVPGGVSDGQWHTVQLKYYNK 1462
Query: 585 ------------------VITRDNSNTH------SLKVDTKVVTQVINGA--KNLDLKGD 618
V+T D +T S+ + Q G K+LDL G
Sbjct: 1463 PLLGQTGLPQGPSEQKVAVVTVDGCDTGVALRFGSVLGNYSCAAQGTQGGSKKSLDLTGP 1522
Query: 619 LYMAGLAQGMYSNLPKLVASR-DGFQGCLASVDLNGRLPDLINDALHRSGQIERGCEGPS 677
L + G+ +LP+ R F GC+ ++ ++ R D+ D + +G + GC
Sbjct: 1523 LLLGGVP-----DLPESFPVRMRQFVGCMRNLQVDSRHIDMA-DFIANNGTVP-GCPAKK 1575
Query: 678 TTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQCNDPGAT--YIFGKSGGLILYTWPAN 735
C ++C N G C+ QW+ F+C+C + + G C A + G S L W
Sbjct: 1576 NVCDSNTCHNGGTCVNQWDAFSCECPL-GFGGKSCAQEMANPQHFLGSS----LVAWHGL 1630
Query: 736 DRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGV-VFNIGTVDISIK 794
P ++ L++ F T DG+L++ + + L + +G + + V G S++
Sbjct: 1631 SLPISQPWYLSLMFRTRQADGVLLQAITRG--RSTITLQLREGHVMLSVEGTGLQASSLR 1688
Query: 795 EERTPVNDGKYH 806
E NDG +H
Sbjct: 1689 LEPGRANDGDWH 1700
Score = 77.8 bits (190), Expect = 5e-14
Identities = 86/351 (24%), Positives = 147/351 (41%), Gaps = 83/351 (23%)
Query: 97 SISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFAVELLDGNLYLLLDMGSGTIK 156
+++ F T E +GL+L+ + N K DF A+E++ + L G T
Sbjct: 1390 TLALSFATKERDGLLLYN-----------GRFNEKHDFVALEVIQEQVQLTFSAGESTTT 1438
Query: 157 VKA-TQKKANDGEWYHVDIQR-------------------------DG-------RSGTI 183
V +DG+W+ V ++ DG R G++
Sbjct: 1439 VSPFVPGGVSDGQWHTVQLKYYNKPLLGQTGLPQGPSEQKVAVVTVDGCDTGVALRFGSV 1498
Query: 184 SVN-SRRTPFTASGESEILDLEGDMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLF 242
N S T G + LDL G + LGG+P+ LP M + VGC+R+L
Sbjct: 1499 LGNYSCAAQGTQGGSKKSLDLTGPLLLGGVPD------LPESFPVRMRQF--VGCMRNLQ 1550
Query: 243 IDGRSKNIRQLAEMQNAAGVKSSCSRMSAKQCDSYPCKNNAVCKDGWNRFICDCTGTGYW 302
+D R + +A+ G C CDS C N C + W+ F C+C G+
Sbjct: 1551 VDSRHID---MADFIANNGTVPGCPAKK-NVCDSNTCHNGGTCVNQWDAFSCECP-LGFG 1605
Query: 303 GRTCERE---------ASILSYDGSMYMKIIMPMVMHTEAEDVSFRFMSQRAYGLLVATT 353
G++C +E +S++++ G + + I P + S F +++A G+L+
Sbjct: 1606 GKSCAQEMANPQHFLGSSLVAWHG-LSLPISQPWYL-------SLMFRTRQADGVLLQAI 1657
Query: 354 SRDSADTLRLELDGGRVKLMVNLDCIRINCNSSKGPETLYAGQKLNDNEWH 404
+R T+ L+L G V M++++ + +S + L G + ND +WH
Sbjct: 1658 TR-GRSTITLQLREGHV--MLSVEGTGLQASSLR----LEPG-RANDGDWH 1700
Score = 55.1 bits (131), Expect = 4e-07
Identities = 47/219 (21%), Positives = 87/219 (39%), Gaps = 40/219 (18%)
Query: 98 ISFDFRTTEPNGLIL--FTHGKPQERKDARSQKNTKVDFFAVELLDGNLYLLLD-MGSGT 154
+S FRT + +G++L T G+ ++L +G++ L ++ G
Sbjct: 1640 LSLMFRTRQADGVLLQAITRGRST---------------ITLQLREGHVMLSVEGTGLQA 1684
Query: 155 IKVKATQKKANDGEWYHVDIQRDGRSG------TISVNSRRTPFTASGESEILDLEGDMY 208
++ +ANDG+W+H + G + +R L L ++
Sbjct: 1685 SSLRLEPGRANDGDWHHAQLALGASGGPGHAILSFDYGQQRAEGNLGPRLHGLHLS-NIT 1743
Query: 209 LGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEMQNAA-GVKSSCS 267
+GG+P G+ G+ GC++ + + + + L + V+ CS
Sbjct: 1744 VGGIPGPAGGVAR-----------GFRGCLQGVRVSDTPEGVNSLDPSHGESINVEQGCS 1792
Query: 268 RMSAKQCDSYPCKNNAVCKDGWNRFICDCTGTGYWGRTC 306
CDS PC N+ C + W+ + C C GY+G C
Sbjct: 1793 LPDP--CDSNPCPANSYCSNDWDSYSCSC-DPGYYGDNC 1828
Score = 50.8 bits (120), Expect = 7e-06
Identities = 68/262 (25%), Positives = 107/262 (40%), Gaps = 37/262 (14%)
Query: 476 CKNG-------DIDYCELKARFGLRNI---IADPVTFKTKSSY----LSLATLQAYTSMH 521
C NG D CE FG ++ +A+P F S LSL Q + +
Sbjct: 1583 CHNGGTCVNQWDAFSCECPLGFGGKSCAQEMANPQHFLGSSLVAWHGLSLPISQPW---Y 1639
Query: 522 LFFQFKTTSPDGFILFNSGDGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSDR----PLN 577
L F+T DG +L G I ++L +G++ + G G ++ +S R N
Sbjct: 1640 LSLMFRTRQADGVLLQAITRGRSTITLQLREGHVMLSVE-GTG---LQASSLRLEPGRAN 1695
Query: 578 DNQWHNVVITRDNSNT--HSLKVDTKVVTQVINGAKNLDLKGDLYMAGLAQGMYSNLPKL 635
D WH+ + S H++ + Q G L G L+++ + G
Sbjct: 1696 DGDWHHAQLALGASGGPGHAI-LSFDYGQQRAEGNLGPRLHG-LHLSNITVGGIPGPAGG 1753
Query: 636 VASRDGFQGCLASVDLNGRLPDLIN--DALH-RSGQIERGCEGPSTTCQEDSCANQGVCM 692
VA GF+GCL V ++ P+ +N D H S +E+GC P C + C C
Sbjct: 1754 VAR--GFRGCLQGVRVSDT-PEGVNSLDPSHGESINVEQGCSLPDP-CDSNPCPANSYCS 1809
Query: 693 QQWEGFTCDCSMTSYSGNQCND 714
W+ ++C C Y G+ C +
Sbjct: 1810 NDWDSYSCSCD-PGYYGDNCTN 1830
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 87.8 bits (216), Expect = 5e-17
Identities = 113/453 (24%), Positives = 184/453 (40%), Gaps = 90/453 (19%)
Query: 484 CELKARFGLRNIIADPVTFKTKS-----SYLSLATL-QAYTSMHLFFQFKTTSPDGFILF 537
C L R GLR + VT T S SYL+L L + + L +FK +PDG +LF
Sbjct: 3912 CHL-GRSGLR--CEEGVTVTTPSLSGAGSYLALPALTNTHHELRLDVEFKPLAPDGVLLF 3968
Query: 538 N---SGDGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSDRPLNDNQWHNVVITRDNSNTH 594
+ SG DF+++ +V G++ + ++LG+G V++ S PL +WH V R N +
Sbjct: 3969 SGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLR--SAEPLALGRWHRVSAERLNKD-G 4025
Query: 595 SLKVD--TKVVTQVINGAKNLDLKGDLYMAGLAQGMYSNLPKLVASRDGFQGCLASVDLN 652
SL+V+ V+ ++ L+L LY+ G+ + L F+GC+ V +N
Sbjct: 4026 SLRVNGGRPVLRSSPGKSQGLNLHTLLYLGGVEPSV--PLSPATNMSAHFRGCVGEVSVN 4083
Query: 653 GRLPDLINDAL--------HRSGQIERG----------------------------CEGP 676
G+ DL L + S ER CE
Sbjct: 4084 GKRLDLTYSFLGSQGIGQCYDSSPCERQPCQHGATCMPAGEYEFQCLCRDGFKGDLCEHE 4143
Query: 677 STTCQ-EDSCANQGVCMQQWEGFTCDCSMTSYSGNQC--------------------ND- 714
CQ + C + G C +G C C + +SG +C ND
Sbjct: 4144 ENPCQLREPCLHGGTC----QGTRCLC-LPGFSGPRCQQGSGHGIAESDWHLEGSGGNDA 4198
Query: 715 PGATYIFGKSGGLILYTWPANDRPSTR-SDRLAVGFSTTVKDGIL----VRIDSAPGLGD 769
PG + G + + R + + + T+ G+L V + A D
Sbjct: 4199 PGQYGAYFHDDGFLAFPGHVFSRSLPEVPETIELEVRTSTASGLLLWQGVEVGEAGQGKD 4258
Query: 770 FLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEH 829
F+ L ++ G + + +G+ + + E P+NDG++H V R G ++QVD +
Sbjct: 4259 FISLGLQDGHLVFRYQLGSGEARLVSE-DPINDGEWHRVTALREGRRGSIQVDGEELVSG 4317
Query: 830 YPTGRQLTIFNTQAQIAIGG-KDKGRLFQGQLS 861
G + + N + + IGG D L G+ S
Sbjct: 4318 RSPGPNVAV-NAKGSVYIGGAPDVATLTGGRFS 4349
Score = 75.5 bits (184), Expect = 3e-13
Identities = 63/252 (25%), Positives = 116/252 (46%), Gaps = 26/252 (10%)
Query: 61 GEVVFKCENVATLDPINFETPEAYISLPKW-NTKRMGSISFDFRTTEPNGLILFTHGKPQ 119
G +CE T+ + +Y++LP NT + +F+ P+G++LF+ GK
Sbjct: 3915 GRSGLRCEEGVTVTTPSLSGAGSYLALPALTNTHHELRLDVEFKPLAPDGVLLFSGGK-- 3972
Query: 120 ERKDARSQKNTKVDFFAVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQRDGR 179
DF ++ ++ G+L ++GSG +++ + A G W+ V +R +
Sbjct: 3973 --------SGPVEDFVSLAMVGGHLEFRYELGSGLAVLRSAEPLAL-GRWHRVSAERLNK 4023
Query: 180 SGTISVNSRRTPFTAS-GESEILDLEGDMYLGGLPENRAGLILPTELWTAMLNYGYVGCI 238
G++ VN R +S G+S+ L+L +YLGG+ + +P T M + + GC+
Sbjct: 4024 DGSLRVNGGRPVLRSSPGKSQGLNLHTLLYLGGVEPS-----VPLSPATNMSAH-FRGCV 4077
Query: 239 RDLFIDGRSKNIRQLAEMQNAAGVKSSCSRMSAKQCDSYPCKNNAVCKD-GWNRFICDCT 297
++ ++G ++L + G + + C+ PC++ A C G F C C
Sbjct: 4078 GEVSVNG-----KRLDLTYSFLGSQGIGQCYDSSPCERQPCQHGATCMPAGEYEFQCLCR 4132
Query: 298 GTGYWGRTCERE 309
G+ G CE E
Sbjct: 4133 -DGFKGDLCEHE 4143
Score = 70.9 bits (172), Expect = 6e-12
Identities = 64/241 (26%), Positives = 107/241 (44%), Gaps = 21/241 (8%)
Query: 75 PINFETPEAYISLPKW-NTKRMGSISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVD 133
P +TP +++ LP + R I FR +G++L+ +G+ + + N + D
Sbjct: 3664 PYFTQTPYSFLPLPTIKDAYRKFEIKITFRPDSADGMLLY-NGQKRVPGSPTNLANRQPD 3722
Query: 134 FFAVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQRDGRSGTISVNSRR-TPF 192
F + L+ G D GSG ++ A G ++ V + R G++ V
Sbjct: 3723 FISFGLVGGRPEFRFDAGSGMATIRHPTPLAL-GHFHTVTLLRSLTQGSLIVGDLAPVNG 3781
Query: 193 TASGESEILDLEGDMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQ 252
T+ G+ + LDL ++YLGG P+ A + A L+ G++GC+R+L I G
Sbjct: 3782 TSQGKFQGLDLNEELYLGGYPDYGA-------IPKAGLSSGFIGCVRELRIQGEEIVFHD 3834
Query: 253 LAEMQNAAGVKSSCSRMSAKQCDSYPCKNNAVCKDG-WNRFICDCTGTGYWGRTCEREAS 311
L A G+ S C C PC+N C D + ++C C G+ G CE +
Sbjct: 3835 L--NLTAHGI-SHC-----PTCRDRPCQNGGQCHDSESSSYVCVCP-AGFTGSRCEHSQA 3885
Query: 312 I 312
+
Sbjct: 3886 L 3886
Score = 67.0 bits (162), Expect = 9e-11
Identities = 87/375 (23%), Positives = 141/375 (37%), Gaps = 59/375 (15%)
Query: 499 PVTFKTKSSYLSLATLQ-AYTSMHLFFQFKTTSPDGFILFN------------SGDGNDF 545
P +T S+L L T++ AY + F+ S DG +L+N + DF
Sbjct: 3664 PYFTQTPYSFLPLPTIKDAYRKFEIKITFRPDSADGMLLYNGQKRVPGSPTNLANRQPDF 3723
Query: 546 IAVELVKGYIHYVFDLGNGPNVIKGNSDRPLNDNQWHNVVITRDNSNTHSLKVDTKVVTQ 605
I+ LV G + FD G+G I+ PL +H V + R + + D V
Sbjct: 3724 ISFGLVGGRPEFRFDAGSGMATIR--HPTPLALGHFHTVTLLRSLTQGSLIVGDLAPVNG 3781
Query: 606 VINGA-KNLDLKGDLYMAGLAQGMYSNLPKLVASRDGFQGCLASVDLNG----------- 653
G + LDL +LY+ G Y +PK S GF GC+ + + G
Sbjct: 3782 TSQGKFQGLDLNEELYLGGYPD--YGAIPKAGLS-SGFIGCVRELRIQGEEIVFHDLNLT 3838
Query: 654 -----RLPDLINDALHRSGQIERG-----------------CE-GPSTTCQEDSCANQGV 690
P + GQ CE + C ++C
Sbjct: 3839 AHGISHCPTCRDRPCQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQALHCHPEACGPDAT 3898
Query: 691 CMQQ--WEGFTCDCSMTSYSGNQCNDPGATYIFGKSGGLILYTWPANDRPSTRSDRLAVG 748
C+ + G+TC C + SG +C + SG PA + RL V
Sbjct: 3899 CVNRPDGRGYTCRCHL-GRSGLRCEEGVTVTTPSLSGAGSYLALPALTN-THHELRLDVE 3956
Query: 749 FSTTVKDGILVRIDSAPG-LGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHV 807
F DG+L+ G + DF+ L + G + + +G+ +++ P+ G++H
Sbjct: 3957 FKPLAPDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGS-GLAVLRSAEPLALGRWHR 4015
Query: 808 VRFTRNGGNATLQVD 822
V R + +L+V+
Sbjct: 4016 VSAERLNKDGSLRVN 4030
Score = 60.8 bits (146), Expect = 6e-09
Identities = 42/152 (27%), Positives = 75/152 (49%), Gaps = 24/152 (15%)
Query: 97 SISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFAVELLDGNLYLLLDMGSGTIK 156
+I + RT+ +GL+L+ + E + DF ++ L DG+L +GSG +
Sbjct: 4229 TIELEVRTSTASGLLLWQGVEVGEAGQGK-------DFISLGLQDGHLVFRYQLGSGEAR 4281
Query: 157 VKATQKKANDGEWYHVDIQRDGRSGTISVN-----SRRTPFTASGESEILDLEGDMYLGG 211
+ ++ NDGEW+ V R+GR G+I V+ S R+P G + ++ +G +Y+GG
Sbjct: 4282 L-VSEDPINDGEWHRVTALREGRRGSIQVDGEELVSGRSP----GPNVAVNAKGSVYIGG 4336
Query: 212 LPENRAGLILPTELWTAMLNYGYVGCIRDLFI 243
P+ L + G GC+++L +
Sbjct: 4337 APD-------VATLTGGRFSSGITGCVKNLVL 4361
Score = 49.3 bits (116), Expect = 2e-05
Identities = 36/142 (25%), Positives = 70/142 (49%), Gaps = 18/142 (12%)
Query: 525 QFKTTSPDGFILFN------SGDGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSDRPLND 578
+ +T++ G +L+ +G G DFI++ L G++ + + LG+G + S+ P+ND
Sbjct: 4233 EVRTSTASGLLLWQGVEVGEAGQGKDFISLGLQDGHLVFRYQLGSGEARLV--SEDPIND 4290
Query: 579 NQWHNVVITRDNSNTHSLKVDTKVVTQVINGAKN--LDLKGDLYMAGLAQGMYSNLPKLV 636
+WH V R+ S++VD + + + N ++ KG +Y+ G ++ L
Sbjct: 4291 GEWHRVTALRE-GRRGSIQVDGEELVSGRSPGPNVAVNAKGSVYIGGA-----PDVATLT 4344
Query: 637 ASR--DGFQGCLASVDLNGRLP 656
R G GC+ ++ L+ P
Sbjct: 4345 GGRFSSGITGCVKNLVLHSARP 4366
Score = 31.2 bits (69), Expect = 5.4
Identities = 12/28 (42%), Positives = 17/28 (60%)
Query: 9 YVGGSPSTADLPGSPVSNNFMGCLKEVV 36
Y+GG+P A L G S+ GC+K +V
Sbjct: 4333 YIGGAPDVATLTGGRFSSGITGCVKNLV 4360
Score = 30.8 bits (68), Expect = 7.1
Identities = 12/41 (29%), Positives = 25/41 (60%)
Query: 2 LGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDI 42
L ++ Y+GG P +P + +S+ F+GC++E+ + +I
Sbjct: 3790 LDLNEELYLGGYPDYGAIPKAGLSSGFIGCVRELRIQGEEI 3830
>gi|119466532 laminin alpha 2 subunit isoform b precursor [Homo
sapiens]
Length = 3118
Score = 87.8 bits (216), Expect = 5e-17
Identities = 157/778 (20%), Positives = 292/778 (37%), Gaps = 144/778 (18%)
Query: 132 VDFFAVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQRDGRSGTISVNSRRTP 191
+DF A+E+ G + L D+GSG +V+ +D WY + R GR+GTISV + P
Sbjct: 2192 IDFLAIEMRKGKVSFLWDVGSGVGRVEYPDLTIDDSYWYRIVASRTGRNGTISVRALDGP 2251
Query: 192 ----------FTASGESEILDLEGD--MYLGGLPENRAGLILPTELWTAMLNYGYVGCIR 239
T+ ILD++ + +++GGL G + + A+ + GC+
Sbjct: 2252 KASIVPSTHHSTSPPGYTILDVDANAMLFVGGL----TGKLKKAD---AVRVITFTGCMG 2304
Query: 240 DLFIDGRSKNIRQLAEMQNAAGVKSSCSRMSAKQCDSYPCKNNAVCKDGWNRFICDCTGT 299
+ + D + + E K+G DC G
Sbjct: 2305 ETYFDNKPIGLWNFRE------------------------------KEG------DCKGC 2328
Query: 300 GYWGRTCEREASILSYDGSMYMKIIMPMVMHTEAEDVSFRFMSQRAYGLLVATTSRDSAD 359
+ + E +I +DG Y + P+ + V F+F + + LL+ +RD D
Sbjct: 2329 TVSPQVEDSEGTI-QFDGEGYALVSRPIRWYPNISTVMFKFRTFSSSALLMYLATRDLRD 2387
Query: 360 TLRLELDGGRVKLMVNLDCIRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLT- 418
+ +EL G +K+ +L G ++ + Q ND +W + + R K ++
Sbjct: 2388 FMSVELTDGHIKVSYDL---------GSGMASVVSNQNHNDGKWKSFTLSRIQKQANISI 2438
Query: 419 VDDDVAEGTMVGDHTRLEFHNIETGIMTE-KRYISVVPS-----------SFIGHLQSLM 466
VD D + + T +N + + K Y +P+ + G L+ +
Sbjct: 2439 VDIDTNQEENIA--TSSSGNNFGLDLKADDKIYFGGLPTLRNLRPEVNLKKYSGCLKDIE 2496
Query: 467 FNGLLYIDLCKNGDIDYCELKARFGLRNIIADPVTFKTKSSYLSLATLQAYTSMHLFFQF 526
+ Y L DY + L N+ V+F K ++ L+ + + F
Sbjct: 2497 ISRTPYNILSSP---DYVGVTKGCSLENVYT--VSFP-KPGFVELSPVPIDVGTEINLSF 2550
Query: 527 KTTSPDGFILFNSGD------------GNDFIAVELVKGYIHYVFDLGNGPNVIKGNSDR 574
T + G IL SG G + + L +G + L G ++ R
Sbjct: 2551 STKNESGIILLGSGGTPAPPRRKRRQTGQAYYVILLNRGRLEV--HLSTGARTMRKIVIR 2608
Query: 575 P----LNDNQWHNVVITRDNSNTHSLKVD-TKVVTQVINGAKNLDLKGDLYMAGLAQGMY 629
P +D + H+V + R +++VD + Q + + +++K L++ G
Sbjct: 2609 PEPNLFHDGREHSVHVERTRG-IFTVQVDENRRYMQNLTVEQPIEVK-KLFVGGAPPEFQ 2666
Query: 630 SNLPKLVASRDGFQGCLASVDLNGRLPDLINDALHRSGQIERGCEGPSTTCQEDSCANQG 689
P + + F+GC+ ++ +N D ++ I R C ED A
Sbjct: 2667 ---PSPLRNIPPFEGCIWNLVINSVPMDFARPVSFKNADIGR-CAHQKLREDEDGAAPAE 2722
Query: 690 VCMQQ----WEGFTCDCSMTSYSGNQCNDPGATYIFGKSGGLILYTWPANDRPSTRSDRL 745
+ +Q F + ++ A I K GL +R+ +
Sbjct: 2723 IVIQPEPVPTPAFPTPTPVLTHGPCAAESEPALLIGSKQFGL------------SRNSHI 2770
Query: 746 AVGFSTT-VKDGIL----VRIDSAPGL---------GDFLQLHIEQGKIGVVFNIGTVDI 791
A+ F T VK+ + VR ++ GL DF + + G +++G+ D
Sbjct: 2771 AIAFDDTKVKNRLTIELEVRTEAESGLLFYMARINHADFATVQLRNGLPYFSYDLGSGDT 2830
Query: 792 SIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGRQLTIFNTQAQIAIGG 849
T +NDG++H ++ R+ L VD + + ++ I + + +GG
Sbjct: 2831 HTMIP-TKINDGQWHKIKIMRSKQEGILYVDG--ASNRTISPKKADILDVVGMLYVGG 2885
Score = 63.2 bits (152), Expect = 1e-09
Identities = 67/248 (27%), Positives = 100/248 (40%), Gaps = 36/248 (14%)
Query: 28 FMGCLKEVVYKNNDIRLELSRLARIADTKMKIYGEVVFKCENVATLDPINFETPEAYISL 87
F GC+ E + N I L R + D K V E D + A +S
Sbjct: 2299 FTGCMGETYFDNKPIGLWNFR-EKEGDCKGCTVSPQVEDSEGTIQFDGEGY----ALVSR 2353
Query: 88 PKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFAVELLDGNLYLL 147
P + ++ F FRT + L+++ +D R DF +VEL DG++ +
Sbjct: 2354 PIRWYPNISTVMFKFRTFSSSALLMYL-----ATRDLR-------DFMSVELTDGHIKVS 2401
Query: 148 LDMGSGTIKVKATQKKANDGEWYHVDIQRDGRSGTISV------NSRRTPFTASGESEIL 201
D+GSG V + Q NDG+W + R + IS+ ++SG + L
Sbjct: 2402 YDLGSGMASVVSNQNH-NDGKWKSFTLSRIQKQANISIVDIDTNQEENIATSSSGNNFGL 2460
Query: 202 DLEGD--MYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEMQNA 259
DL+ D +Y GGLP R L + Y GC++D+ I NI +
Sbjct: 2461 DLKADDKIYFGGLPTLR-------NLRPEVNLKKYSGCLKDIEISRTPYNI---LSSPDY 2510
Query: 260 AGVKSSCS 267
GV CS
Sbjct: 2511 VGVTKGCS 2518
Score = 60.1 bits (144), Expect = 1e-08
Identities = 43/168 (25%), Positives = 72/168 (42%), Gaps = 19/168 (11%)
Query: 85 ISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFAVELLDGNL 144
I+ K +I + RT +GL+ + + DF V+L +G
Sbjct: 2772 IAFDDTKVKNRLTIELEVRTEAESGLLFYM------------ARINHADFATVQLRNGLP 2819
Query: 145 YLLLDMGSGTIKVKATQKKANDGEWYHVDIQRDGRSGTISVNSRRTPFTASGESEILDLE 204
Y D+GSG K NDG+W+ + I R + G + V+ + +++ILD+
Sbjct: 2820 YFSYDLGSGDTHTMIPTK-INDGQWHKIKIMRSKQEGILYVDGASNRTISPKKADILDVV 2878
Query: 205 GDMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQ 252
G +Y+GGLP N T + Y GC+R+L + ++ Q
Sbjct: 2879 GMLYVGGLPINY------TTRRIGPVTYSIDGCVRNLHMAEAPADLEQ 2920
Score = 50.1 bits (118), Expect = 1e-05
Identities = 129/690 (18%), Positives = 258/690 (37%), Gaps = 102/690 (14%)
Query: 2 LGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDIRLELSRLARIADTKMKIYG 61
L +DD Y GG P+ +L + GCLK++ + LS + TK
Sbjct: 2462 LKADDKIYFGGLPTLRNLRPEVNLKKYSGCLKDIEISRTPYNI-LSSPDYVGVTKG---- 2516
Query: 62 EVVFKCENVATLDPINFETPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHG---KP 118
ENV T ++F P ++ L I+ F T +G+IL G P
Sbjct: 2517 ---CSLENVYT---VSFPKP-GFVELSPVPIDVGTEINLSFSTKNESGIILLGSGGTPAP 2569
Query: 119 QERKDARSQKNTKVDFFAVELLDGNLYLLLDMGSGTIKVKATQKKAN---DGEWYHVDIQ 175
RK ++ T ++ + L G L + L G+ T++ + + N DG + V ++
Sbjct: 2570 PRRK----RRQTGQAYYVILLNRGRLEVHLSTGARTMRKIVIRPEPNLFHDGREHSVHVE 2625
Query: 176 RDGRSGTISVNSRRTPFTASGESEILDLEGDMYLGGLPENRAGLILPTELWTAMLNYGYV 235
R T+ V+ R + ++++ +++GG P P+ L +
Sbjct: 2626 RTRGIFTVQVDENRRYMQNLTVEQPIEVK-KLFVGGAPPE----FQPSPLRNIP---PFE 2677
Query: 236 GCIRDLFIDGRSKNIRQLAEMQNAAGVKSSCSRMSAKQCDSYPCK--------------- 280
GCI +L I+ + + +NA + + ++ + + P +
Sbjct: 2678 GCIWNLVINSVPMDFARPVSFKNADIGRCAHQKLREDEDGAAPAEIVIQPEPVPTPAFPT 2737
Query: 281 -----NNAVCKDGWNRFICDCTGTGYWGRTCEREASILSYDGSMYMKIIMPMVMHTEAED 335
+ C + G+ +G + +I D + ++ + + + TEAE
Sbjct: 2738 PTPVLTHGPCAAESEPALL--IGSKQFGLSRNSHIAIAFDDTKVKNRLTIELEVRTEAES 2795
Query: 336 VSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLDCIRINCNSSKGPETLYAG 395
GLL + AD ++L G +L G
Sbjct: 2796 -----------GLLFYMARINHADFATVQLRNGLPYFSYDL---------GSGDTHTMIP 2835
Query: 396 QKLNDNEWHTVRVVRRGKSLKLTVDDDVAEGTMVGDHTRLEFHNIETGIMTEKRYISVVP 455
K+ND +WH ++++ R K + D + T+ + + ++ G++ Y+ +P
Sbjct: 2836 TKINDGQWHKIKIM-RSKQEGILYVDGASNRTI--SPKKADILDV-VGML----YVGGLP 2887
Query: 456 SSF----IGHLQSLMFNGLLYIDLCKN-GDIDYCELKARFGLRNIIADPVTFKTKSSYL- 509
++ IG + + + + + + D++ G A T+ + +
Sbjct: 2888 INYTTRRIGPVTYSIDGCVRNLHMAEAPADLEQPTSSFHVGTCFANAQRGTYFDGTGFAK 2947
Query: 510 SLATLQAYTSMHLFFQFKTTSPDGFILFNSGDGNDFIAVELVKGYIHYVFDLGNGPNVIK 569
++ + + + F+F+TT+ G +L S D + +E++ + + D G G
Sbjct: 2948 AVGGFKVGLDLLVEFEFRTTTTTGVLLGISSQKMDGMGIEMIDEKLMFHVDNGAGRFTAV 3007
Query: 570 GNSDRP--LNDNQWHNVVITRDNSNTHSLKVDTKVVTQVINGAK-NLDLKGDLYMAGLAQ 626
++ P L D QWH V + +V Q N A + D +++ G
Sbjct: 3008 YDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTSADTNDPVFVGGFPD 3067
Query: 627 -----GMYSNLPKLVASRDGFQGCLASVDL 651
G+ +++P F+GC+ S+ L
Sbjct: 3068 DLKQFGLTTSIP--------FRGCIRSLKL 3089
Score = 38.9 bits (89), Expect = 0.026
Identities = 19/67 (28%), Positives = 38/67 (56%), Gaps = 2/67 (2%)
Query: 527 KTTSPDGFILF-NSGDGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSDRPLNDNQWHNVV 585
KT D + + S DF+A+E+ KG + +++D+G+G ++ D ++D+ W+ +V
Sbjct: 2175 KTAVADNLLFYLGSAKFIDFLAIEMRKGKVSFLWDVGSGVGRVE-YPDLTIDDSYWYRIV 2233
Query: 586 ITRDNSN 592
+R N
Sbjct: 2234 ASRTGRN 2240
Score = 37.4 bits (85), Expect = 0.076
Identities = 23/98 (23%), Positives = 51/98 (52%), Gaps = 2/98 (2%)
Query: 724 SGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVV 783
SGG + T+ + + ++ + V T V D +L + SA + DFL + + +GK+ +
Sbjct: 2150 SGGDCIRTYKPEIKKGSYNN-IVVNVKTAVADNLLFYLGSAKFI-DFLAIEMRKGKVSFL 2207
Query: 784 FNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQV 821
+++G+ ++ ++D ++ + +R G N T+ V
Sbjct: 2208 WDVGSGVGRVEYPDLTIDDSYWYRIVASRTGRNGTISV 2245
>gi|28559088 laminin alpha 2 subunit isoform a precursor [Homo
sapiens]
Length = 3122
Score = 86.7 bits (213), Expect = 1e-16
Identities = 157/781 (20%), Positives = 296/781 (37%), Gaps = 146/781 (18%)
Query: 132 VDFFAVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQRDGRSGTISVNSRRTP 191
+DF A+E+ G + L D+GSG +V+ +D WY + R GR+GTISV + P
Sbjct: 2192 IDFLAIEMRKGKVSFLWDVGSGVGRVEYPDLTIDDSYWYRIVASRTGRNGTISVRALDGP 2251
Query: 192 ----------FTASGESEILDLEGD--MYLGGLPENRAGLILPTELWTAMLNYGYVGCIR 239
T+ ILD++ + +++GGL G + + A+ + GC+
Sbjct: 2252 KASIVPSTHHSTSPPGYTILDVDANAMLFVGGL----TGKLKKAD---AVRVITFTGCMG 2304
Query: 240 DLFIDGRSKNIRQLAEMQNAAGVKSSCSRMSAKQCDSYPCKNNAVCKDGWNRFICDCTGT 299
+ + D + + E K+G DC G
Sbjct: 2305 ETYFDNKPIGLWNFRE------------------------------KEG------DCKGC 2328
Query: 300 GYWGRTCEREASILSYDGSMYMKIIMPMVMHTEAEDVSFRFMSQRAYGLLVATTSRDSAD 359
+ + E +I +DG Y + P+ + V F+F + + LL+ +RD D
Sbjct: 2329 TVSPQVEDSEGTI-QFDGEGYALVSRPIRWYPNISTVMFKFRTFSSSALLMYLATRDLRD 2387
Query: 360 TLRLELDGGRVKLMVNLDCIRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTV 419
+ +EL G +K+ +L G ++ + Q ND +W + + R K +++
Sbjct: 2388 FMSVELTDGHIKVSYDL---------GSGMASVVSNQNHNDGKWKSFTLSRIQKQANISI 2438
Query: 420 -------DDDVAEGTMVGDHTRLEF---HNIETGIMTEKRYIS------VVPSSFIGHLQ 463
++++A + G++ L+ I G + R +S V + G L+
Sbjct: 2439 VDIDTNQEENIATSSS-GNNFGLDLKADDKIYFGGLPTLRNLSMKARPEVNLKKYSGCLK 2497
Query: 464 SLMFNGLLYIDLCKNGDIDYCELKARFGLRNIIADPVTFKTKSSYLSLATLQAYTSMHLF 523
+ + Y L DY + L N+ V+F K ++ L+ + +
Sbjct: 2498 DIEISRTPYNIL---SSPDYVGVTKGCSLENVYT--VSF-PKPGFVELSPVPIDVGTEIN 2551
Query: 524 FQFKTTSPDGFILFNSG------------DGNDFIAVELVKGYIHYVFDLGNGPNVIKGN 571
F T + G IL SG G + + L +G + L G ++
Sbjct: 2552 LSFSTKNESGIILLGSGGTPAPPRRKRRQTGQAYYVILLNRGRLE--VHLSTGARTMRKI 2609
Query: 572 SDRP----LNDNQWHNVVITRDNSNTHSLKVD-TKVVTQVINGAKNLDLKGDLYMAGLAQ 626
RP +D + H+V + R +++VD + Q + + +++K L++ G
Sbjct: 2610 VIRPEPNLFHDGREHSVHVER-TRGIFTVQVDENRRYMQNLTVEQPIEVK-KLFVGGAPP 2667
Query: 627 GMYSNLPKLVASRDGFQGCLASVDLNGRLPDLINDALHRSGQIERGCEGPSTTCQEDSCA 686
P + + F+GC+ ++ +N D ++ I R C ED A
Sbjct: 2668 EFQ---PSPLRNIPPFEGCIWNLVINSVPMDFARPVSFKNADIGR-CAHQKLREDEDGAA 2723
Query: 687 NQGVCMQ----QWEGFTCDCSMTSYSGNQCNDPGATYIFGKSGGLILYTWPANDRPSTRS 742
+ +Q F + ++ A I K GL +R+
Sbjct: 2724 PAEIVIQPEPVPTPAFPTPTPVLTHGPCAAESEPALLIGSKQFGL------------SRN 2771
Query: 743 DRLAVGF-STTVKDGIL----VRIDSAPGL---------GDFLQLHIEQGKIGVVFNIGT 788
+A+ F T VK+ + VR ++ GL DF + + G +++G+
Sbjct: 2772 SHIAIAFDDTKVKNRLTIELEVRTEAESGLLFYMARINHADFATVQLRNGLPYFSYDLGS 2831
Query: 789 VDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGRQLTIFNTQAQIAIG 848
D T +NDG++H ++ R+ L VD + + ++ I + + +G
Sbjct: 2832 GDTHTMIP-TKINDGQWHKIKIMRSKQEGILYVDG--ASNRTISPKKADILDVVGMLYVG 2888
Query: 849 G 849
G
Sbjct: 2889 G 2889
Score = 63.2 bits (152), Expect = 1e-09
Identities = 67/248 (27%), Positives = 101/248 (40%), Gaps = 32/248 (12%)
Query: 28 FMGCLKEVVYKNNDIRLELSRLARIADTKMKIYGEVVFKCENVATLDPINFETPEAYISL 87
F GC+ E + N I L R + D K V E D + A +S
Sbjct: 2299 FTGCMGETYFDNKPIGLWNFR-EKEGDCKGCTVSPQVEDSEGTIQFDGEGY----ALVSR 2353
Query: 88 PKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFAVELLDGNLYLL 147
P + ++ F FRT + L+++ +D R DF +VEL DG++ +
Sbjct: 2354 PIRWYPNISTVMFKFRTFSSSALLMYL-----ATRDLR-------DFMSVELTDGHIKVS 2401
Query: 148 LDMGSGTIKVKATQKKANDGEWYHVDIQRDGRSGTISV------NSRRTPFTASGESEIL 201
D+GSG V + Q NDG+W + R + IS+ ++SG + L
Sbjct: 2402 YDLGSGMASVVSNQNH-NDGKWKSFTLSRIQKQANISIVDIDTNQEENIATSSSGNNFGL 2460
Query: 202 DLEGD--MYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEMQNA 259
DL+ D +Y GGLP R L + + Y GC++D+ I NI +
Sbjct: 2461 DLKADDKIYFGGLPTLRN---LSMKARPEVNLKKYSGCLKDIEISRTPYNI---LSSPDY 2514
Query: 260 AGVKSSCS 267
GV CS
Sbjct: 2515 VGVTKGCS 2522
Score = 60.1 bits (144), Expect = 1e-08
Identities = 43/168 (25%), Positives = 72/168 (42%), Gaps = 19/168 (11%)
Query: 85 ISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFAVELLDGNL 144
I+ K +I + RT +GL+ + + DF V+L +G
Sbjct: 2776 IAFDDTKVKNRLTIELEVRTEAESGLLFYM------------ARINHADFATVQLRNGLP 2823
Query: 145 YLLLDMGSGTIKVKATQKKANDGEWYHVDIQRDGRSGTISVNSRRTPFTASGESEILDLE 204
Y D+GSG K NDG+W+ + I R + G + V+ + +++ILD+
Sbjct: 2824 YFSYDLGSGDTHTMIPTK-INDGQWHKIKIMRSKQEGILYVDGASNRTISPKKADILDVV 2882
Query: 205 GDMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQ 252
G +Y+GGLP N T + Y GC+R+L + ++ Q
Sbjct: 2883 GMLYVGGLPINY------TTRRIGPVTYSIDGCVRNLHMAEAPADLEQ 2924
Score = 47.0 bits (110), Expect = 1e-04
Identities = 131/694 (18%), Positives = 260/694 (37%), Gaps = 106/694 (15%)
Query: 2 LGSDDFFYVGGSPSTADLP--GSPVSN--NFMGCLKEVVYKNNDIRLELSRLARIADTKM 57
L +DD Y GG P+ +L P N + GCLK++ + LS + TK
Sbjct: 2462 LKADDKIYFGGLPTLRNLSMKARPEVNLKKYSGCLKDIEISRTPYNI-LSSPDYVGVTKG 2520
Query: 58 KIYGEVVFKCENVATLDPINFETPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHG- 116
ENV T ++F P ++ L I+ F T +G+IL G
Sbjct: 2521 -------CSLENVYT---VSFPKP-GFVELSPVPIDVGTEINLSFSTKNESGIILLGSGG 2569
Query: 117 --KPQERKDARSQKNTKVDFFAVELLDGNLYLLLDMGSGTIKVKATQKKAN---DGEWYH 171
P RK ++ T ++ + L G L + L G+ T++ + + N DG +
Sbjct: 2570 TPAPPRRK----RRQTGQAYYVILLNRGRLEVHLSTGARTMRKIVIRPEPNLFHDGREHS 2625
Query: 172 VDIQRDGRSGTISVNSRRTPFTASGESEILDLEGDMYLGGLPENRAGLILPTELWTAMLN 231
V ++R T+ V+ R + ++++ +++GG P P+ L
Sbjct: 2626 VHVERTRGIFTVQVDENRRYMQNLTVEQPIEVK-KLFVGGAPPE----FQPSPLRNIP-- 2678
Query: 232 YGYVGCIRDLFIDGRSKNIRQLAEMQNAAGVKSSCSRMSAKQCDSYPCK----------- 280
+ GCI +L I+ + + +NA + + ++ + + P +
Sbjct: 2679 -PFEGCIWNLVINSVPMDFARPVSFKNADIGRCAHQKLREDEDGAAPAEIVIQPEPVPTP 2737
Query: 281 ---------NNAVCKDGWNRFICDCTGTGYWGRTCEREASILSYDGSMYMKIIMPMVMHT 331
+ C + G+ +G + +I D + ++ + + + T
Sbjct: 2738 AFPTPTPVLTHGPCAAESEPALL--IGSKQFGLSRNSHIAIAFDDTKVKNRLTIELEVRT 2795
Query: 332 EAEDVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLDCIRINCNSSKGPET 391
EAE GLL + AD ++L G +L G
Sbjct: 2796 EAES-----------GLLFYMARINHADFATVQLRNGLPYFSYDL---------GSGDTH 2835
Query: 392 LYAGQKLNDNEWHTVRVVRRGKSLKLTVDDDVAEGTMVGDHTRLEFHNIETGIMTEKRYI 451
K+ND +WH ++++ R K + D + T+ + + ++ G++ Y+
Sbjct: 2836 TMIPTKINDGQWHKIKIM-RSKQEGILYVDGASNRTI--SPKKADILDV-VGML----YV 2887
Query: 452 SVVPSSF----IGHLQSLMFNGLLYIDLCKN-GDIDYCELKARFGLRNIIADPVTFKTKS 506
+P ++ IG + + + + + + D++ G A T+ +
Sbjct: 2888 GGLPINYTTRRIGPVTYSIDGCVRNLHMAEAPADLEQPTSSFHVGTCFANAQRGTYFDGT 2947
Query: 507 SYL-SLATLQAYTSMHLFFQFKTTSPDGFILFNSGDGNDFIAVELVKGYIHYVFDLGNGP 565
+ ++ + + + F+F+TT+ G +L S D + +E++ + + D G G
Sbjct: 2948 GFAKAVGGFKVGLDLLVEFEFRTTTTTGVLLGISSQKMDGMGIEMIDEKLMFHVDNGAGR 3007
Query: 566 NVIKGNSDRP--LNDNQWHNVVITRDNSNTHSLKVDTKVVTQVINGAK-NLDLKGDLYMA 622
++ P L D QWH V + +V Q N A + D +++
Sbjct: 3008 FTAVYDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTSADTNDPVFVG 3067
Query: 623 GLAQ-----GMYSNLPKLVASRDGFQGCLASVDL 651
G G+ +++P F+GC+ S+ L
Sbjct: 3068 GFPDDLKQFGLTTSIP--------FRGCIRSLKL 3093
Score = 38.9 bits (89), Expect = 0.026
Identities = 19/67 (28%), Positives = 38/67 (56%), Gaps = 2/67 (2%)
Query: 527 KTTSPDGFILF-NSGDGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSDRPLNDNQWHNVV 585
KT D + + S DF+A+E+ KG + +++D+G+G ++ D ++D+ W+ +V
Sbjct: 2175 KTAVADNLLFYLGSAKFIDFLAIEMRKGKVSFLWDVGSGVGRVE-YPDLTIDDSYWYRIV 2233
Query: 586 ITRDNSN 592
+R N
Sbjct: 2234 ASRTGRN 2240
Score = 37.4 bits (85), Expect = 0.076
Identities = 23/98 (23%), Positives = 51/98 (52%), Gaps = 2/98 (2%)
Query: 724 SGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVV 783
SGG + T+ + + ++ + V T V D +L + SA + DFL + + +GK+ +
Sbjct: 2150 SGGDCIRTYKPEIKKGSYNN-IVVNVKTAVADNLLFYLGSAKFI-DFLAIEMRKGKVSFL 2207
Query: 784 FNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQV 821
+++G+ ++ ++D ++ + +R G N T+ V
Sbjct: 2208 WDVGSGVGRVEYPDLTIDDSYWYRIVASRTGRNGTISV 2245
>gi|41327708 crumbs homolog 1 precursor [Homo sapiens]
Length = 1406
Score = 85.9 bits (211), Expect = 2e-16
Identities = 151/702 (21%), Positives = 256/702 (36%), Gaps = 148/702 (21%)
Query: 274 CDSYPCKNNAVC----KDGWNRFICDCTGTGYWGRTCEREASILSYDGSMYMKIIMPMVM 329
C C NN C +DG + F C C +GY G CE A+ LS++G ++ + V
Sbjct: 445 CTHQQCLNNGTCIPHFQDGQHGFSCLCP-SGYTGSLCEI-ATTLSFEGDGFLWVKSGSVT 502
Query: 330 HTEAE-DVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLDCIRINCNSSKG 388
+ +++ RF + + LL+ ++RD ++LEL G + L + ++ N SK
Sbjct: 503 TKGSVCNIALRFQTVQPMALLLFRSNRDVF--VKLELLSGYIHLSIQVN------NQSK- 553
Query: 389 PETLYAGQKLNDNEWHTVRVVRRGKSLKLTVDDDVAEGTMVGDHTRLE-------FHN-- 439
L+ +D EWH V V+ +DD E + T LE F N
Sbjct: 554 -VLLFISHNTSDGEWHFVEVIFAEAVTLTLIDDSCKEKCIAKAPTPLESDQSICAFQNSF 612
Query: 440 --------IETGIMTEKRYISVVPSSFIGHLQSLM--FNGLLYIDLCKNGDI-------- 481
G+ Y SF+G LQ + +N + ++ +
Sbjct: 613 LGGLPVGMTSNGVALLNFYNMPSTPSFVGCLQDIKIDWNHITLENISSGSSLNVKAGCVR 672
Query: 482 -DYCELKARFG------------------------LRNIIADPVTFKTKSSYLSLATLQA 516
D+CE + LR +A + Y+ ++
Sbjct: 673 KDWCESQPCQSRGRCINLWLSYQCDCHRPYEGPNCLREYVAGRFGQDDSTGYVIFTLDES 732
Query: 517 Y-TSMHLFFQFKTTSPDGFILFNSGDGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSDRP 575
Y ++ L +T P G +L +I V L +G + + PN K
Sbjct: 733 YGDTISLSMFVRTLQPSGLLLALENSTYQYIRVWLERGRLAMLT-----PNSPKLVVKFV 787
Query: 576 LNDNQWHNVVITRDNSNTHSLKVDTKVVTQVINGAKNLDL---------KGD-LYMAGLA 625
LND H + SLK+ + ++ ++NL KGD +Y+ GL
Sbjct: 788 LNDGNVHLI----------SLKIKPYKI-ELYQSSQNLGFISASTWKIEKGDVIYIGGLP 836
Query: 626 QGMYSNLPKLVASRDGFQGCLASVDLNGRLPDLINDALHRSG------QIERGCEGPSTT 679
+ L + F+GC+ V LN + + + + + + +GC G ++
Sbjct: 837 DKQETEL-----NGGFFKGCIQDVRLNNQNLEFFPNPTNNASLNPVLVNVTQGCAGDNS- 890
Query: 680 CQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQCNDPG----------------------- 716
C+ + C N GVC +W+ F+C C + SG C +
Sbjct: 891 CKSNPCHNGGVCHSRWDDFSCSCPALT-SGKACEEVQWCGFSPCPHGAQCQPVLQGFECI 949
Query: 717 ATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIE 776
A +F G IL+ +N + + GF T + I++ + P +FL + I+
Sbjct: 950 ANAVFNGQSGQILFR--SNGNITRELTNITFGFRTRDANVIILHAEKEP---EFLNISIQ 1004
Query: 777 QGKIGVVFNIGTVDISIK-EERTPVNDGKYHVVRFTRNG-----GNATLQVDNWP--VNE 828
++ G + VNDG +H V + ++VDN V
Sbjct: 1005 DSRLFFQLQSGNSFYMLSLTSLQSVNDGTWHEVTLSMTDPLSQTSRWQMEVDNETPFVTS 1064
Query: 829 HYPTGRQLTIFNTQAQIAIGGK--DKGRLFQGQLSGLYYDGL 868
TG L I +G + D + QG LS + G+
Sbjct: 1065 TIATG-SLNFLKDNTDIYVGDRAIDNIKGLQGCLSTIEIGGI 1105
Score = 73.2 bits (178), Expect = 1e-12
Identities = 96/407 (23%), Positives = 174/407 (42%), Gaps = 58/407 (14%)
Query: 521 HLFFQFKTTSPDGFILFNSGDGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSDRPLNDNQ 580
++ +F+T P +LF S + + F+ +EL+ GYIH + N V+ S +D +
Sbjct: 509 NIALRFQTVQPMALLLFRS-NRDVFVKLELLSGYIHLSIQVNNQSKVLLFISHNT-SDGE 566
Query: 581 WHNVVITRDNSNTHSLKVDT---KVVTQV---INGAKNLDLKGDLYMAGLAQGMYSNLPK 634
WH V + + T +L D+ K + + + +++ + ++ GL GM SN
Sbjct: 567 WHFVEVIFAEAVTLTLIDDSCKEKCIAKAPTPLESDQSICAFQNSFLGGLPVGMTSNGVA 626
Query: 635 LV-----ASRDGFQGCLASVDLNGRLPDLINDALHRSGQIERGCEGPSTTCQEDSCANQG 689
L+ S F GCL + ++ L N + S ++ GC C+ C ++G
Sbjct: 627 LLNFYNMPSTPSFVGCLQDIKIDWNHITLENISSGSSLNVKAGCVRKDW-CESQPCQSRG 685
Query: 690 VCMQQWEGFTCDCSMTSYSGNQCNDPGATYIFGK--SGGLILYTWPANDRPSTRSDRLAV 747
C+ W + CDC Y G C FG+ S G +++T D + L++
Sbjct: 686 RCINLWLSYQCDCH-RPYEGPNCLREYVAGRFGQDDSTGYVIFTL---DESYGDTISLSM 741
Query: 748 GFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHV 807
T G+L+ ++++ ++++ +E+G++ ++ TP N K V
Sbjct: 742 FVRTLQPSGLLLALENS--TYQYIRVWLERGRLAML--------------TP-NSPKL-V 783
Query: 808 VRFTRNGGNA---TLQVDNWPVNEHYPTGRQLTIFNTQA-------QIAIGG---KDKGR 854
V+F N GN +L++ + + E Y + + L + I IGG K +
Sbjct: 784 VKFVLNDGNVHLISLKIKPYKI-ELYQSSQNLGFISASTWKIEKGDVIYIGGLPDKQETE 842
Query: 855 LFQGQLSGLYYDGLKVLNMAAENNPNIKINGSVRLVGEVPSILGTTQ 901
L G G D +++ N E PN N S+ P ++ TQ
Sbjct: 843 LNGGFFKGCIQD-VRLNNQNLEFFPNPTNNASLN-----PVLVNVTQ 883
Score = 67.0 bits (162), Expect = 9e-11
Identities = 71/293 (24%), Positives = 127/293 (43%), Gaps = 42/293 (14%)
Query: 97 SISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFAVELLDGNLYLLLDMGSGTIK 156
+I+ F+T +P L+LF RS ++ F +ELL G ++L + + + +
Sbjct: 509 NIALRFQTVQPMALLLF-----------RSNRDV---FVKLELLSGYIHLSIQVNNQSKV 554
Query: 157 VKATQKKANDGEWYHVD-IQRDGRSGTISVNS------RRTPFTASGESEILDLEGDMYL 209
+ +DGEW+ V+ I + + T+ +S + P + I + +L
Sbjct: 555 LLFISHNTSDGEWHFVEVIFAEAVTLTLIDDSCKEKCIAKAPTPLESDQSICAFQNS-FL 613
Query: 210 GGLPENRAGLILPTELWTAMLNY-------GYVGCIRDLFIDGRSKNIRQLAEMQNAAGV 262
GGLP T A+LN+ +VGC++D+ ID + ++ ++ V
Sbjct: 614 GGLPVGM------TSNGVALLNFYNMPSTPSFVGCLQDIKIDWNHITLENISS-GSSLNV 666
Query: 263 KSSCSRMSAKQCDSYPCKNNAVCKDGWNRFICDCTGTGYWGRTCERE--ASILSYDGSMY 320
K+ C R C+S PC++ C + W + CDC Y G C RE A D S
Sbjct: 667 KAGCVRKD--WCESQPCQSRGRCINLWLSYQCDC-HRPYEGPNCLREYVAGRFGQDDSTG 723
Query: 321 MKIIMPMVMHTEAEDVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLM 373
I + + +S + + GLL+A + +R+ L+ GR+ ++
Sbjct: 724 YVIFTLDESYGDTISLSMFVRTLQPSGLLLA-LENSTYQYIRVWLERGRLAML 775
Score = 52.8 bits (125), Expect = 2e-06
Identities = 56/233 (24%), Positives = 96/233 (41%), Gaps = 44/233 (18%)
Query: 92 TKRMGSISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFAVELLDGNLYLLLDMG 151
T+ + +I+F FRT + N +IL +P+ F + + D L+ L G
Sbjct: 970 TRELTNITFGFRTRDANVIILHAEKEPE--------------FLNISIQDSRLFFQLQSG 1015
Query: 152 SGTIKVKATQ-KKANDGEWYHVDIQRDGRSGTISVNSR-------RTPFT----ASGESE 199
+ + T + NDG W+ V + + +S SR TPF A+G
Sbjct: 1016 NSFYMLSLTSLQSVNDGTWHEVTLSM---TDPLSQTSRWQMEVDNETPFVTSTIATGSLN 1072
Query: 200 ILDLEGDMYLGGLP-ENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEMQ- 257
L D+Y+G +N GL L+ +G I + + I + E Q
Sbjct: 1073 FLKDNTDIYVGDRAIDNIKGL-------QGCLSTIEIGGIYLSYFENVHGFINKPQEEQF 1125
Query: 258 ---NAAGVKSSCSRMSAKQCDSYPCKNNAVCKDGWNRFICDCTGTGYWGRTCE 307
+ V + C +++ C+S PC + C+D ++ + C C G+ G+ CE
Sbjct: 1126 LKISTNSVVTGCLQLNV--CNSNPCLHGGNCEDIYSSYHCSCP-LGWSGKHCE 1175
Score = 49.3 bits (116), Expect = 2e-05
Identities = 35/116 (30%), Positives = 53/116 (45%), Gaps = 10/116 (8%)
Query: 202 DLEGDMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGR-SKNIRQLAEMQNAA 260
DLE D +N A + +T + + Y G +L ID S+ A Q+A
Sbjct: 184 DLEVDECASDPCKNEATCLNEIGRYTCICPHNYSGVNCELEIDECWSQPCLNGATCQDAL 243
Query: 261 GVK-SSCS--------RMSAKQCDSYPCKNNAVCKDGWNRFICDCTGTGYWGRTCE 307
G C+ ++ +C S PC + +C DG NR+ C+CTG+G+ G CE
Sbjct: 244 GAYFCDCAPGFLGDHCELNTDECASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCE 299
Score = 49.3 bits (116), Expect = 2e-05
Identities = 56/218 (25%), Positives = 94/218 (43%), Gaps = 39/218 (17%)
Query: 97 SISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFAVELLDGNLYLLLDMGSGTIK 156
S+S RT +P+GL+L + +N+ + V L G L +L S +
Sbjct: 738 SLSMFVRTLQPSGLLL-------------ALENSTYQYIRVWLERGRLAMLTP-NSPKLV 783
Query: 157 VKATQKKANDGEWYHVDIQRDGRSGTISVNSRRTPFTASGESEILDLEGDM-YLGGLPEN 215
VK NDG + + ++ + +S+ F ++ +I +GD+ Y+GGLP+
Sbjct: 784 VKFV---LNDGNVHLISLKIKPYKIELYQSSQNLGFISASTWKIE--KGDVIYIGGLPDK 838
Query: 216 RAGLILPTELWTAMLNYGYV-GCIRDLFIDGRSKNIRQLAEMQNAAGVKSSCSRMSA--- 271
+ TEL N G+ GCI+D+ ++ ++N+ N A + ++
Sbjct: 839 QE-----TEL-----NGGFFKGCIQDVRLN--NQNLEFFPNPTNNASLNPVLVNVTQGCA 886
Query: 272 --KQCDSYPCKNNAVCKDGWNRFICDCTGTGYWGRTCE 307
C S PC N VC W+ F C C G+ CE
Sbjct: 887 GDNSCKSNPCHNGGVCHSRWDDFSCSCPALTS-GKACE 923
Score = 43.5 bits (101), Expect = 0.001
Identities = 42/213 (19%), Positives = 86/213 (40%), Gaps = 34/213 (15%)
Query: 521 HLFFQFKTTSPDGFILFNSGDGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSDRPLNDNQ 580
++ F F+T + IL + +F+ + + + + GN ++ S + +ND
Sbjct: 975 NITFGFRTRDANVIILHAEKEP-EFLNISIQDSRLFFQLQSGNSFYMLSLTSLQSVNDGT 1033
Query: 581 WHNVVITRDN----SNTHSLKVDTK---VVTQVINGAKN-LDLKGDLYMAGLAQGMYSNL 632
WH V ++ + ++ ++VD + V + + G+ N L D+Y+ A
Sbjct: 1034 WHEVTLSMTDPLSQTSRWQMEVDNETPFVTSTIATGSLNFLKDNTDIYVGDRA------- 1086
Query: 633 PKLVASRDGFQGCLASVDLNG-------RLPDLINDALHR------SGQIERGCEGPSTT 679
+ + G QGCL+++++ G + IN + + GC
Sbjct: 1087 ---IDNIKGLQGCLSTIEIGGIYLSYFENVHGFINKPQEEQFLKISTNSVVTGCL-QLNV 1142
Query: 680 CQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQC 712
C + C + G C + + C C + +SG C
Sbjct: 1143 CNSNPCLHGGNCEDIYSSYHCSCPL-GWSGKHC 1174
Score = 43.1 bits (100), Expect = 0.001
Identities = 21/57 (36%), Positives = 29/57 (50%), Gaps = 1/57 (1%)
Query: 260 AGVKSSCSRMSAKQCDSYPCKNNAVCKDGWNRFICDCTGTGYWGRTCEREASILSYD 316
AG + +C S PC+N AVC+DG + + C C GY GR C+ E + D
Sbjct: 138 AGYAGRFCEIDHDECASSPCQNGAVCQDGIDGYSCFCV-PGYQGRHCDLEVDECASD 193
Score = 37.4 bits (85), Expect = 0.076
Identities = 16/34 (47%), Positives = 19/34 (55%), Gaps = 1/34 (2%)
Query: 274 CDSYPCKNNAVCKDGWNRFICDCTGTGYWGRTCE 307
C S PC NNA C+D + + C C GY G CE
Sbjct: 305 CWSKPCHNNATCEDSVDNYTCHC-WPGYTGAQCE 337
Score = 34.7 bits (78), Expect = 0.49
Identities = 16/47 (34%), Positives = 19/47 (40%), Gaps = 5/47 (10%)
Query: 673 CEGPSTTCQEDSCANQGVCMQQWEGFTCDC-----SMTSYSGNQCND 714
CE C + C N G C +TC C S T Y G C+D
Sbjct: 394 CEEDVNECSSNPCQNGGTCENLPGNYTCHCPFDNLSRTFYGGRDCSD 440
Score = 33.9 bits (76), Expect = 0.84
Identities = 15/48 (31%), Positives = 21/48 (43%), Gaps = 1/48 (2%)
Query: 666 SGQIERGCEGPSTTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQCN 713
+G R CE C C N VC +G++C C + Y G C+
Sbjct: 138 AGYAGRFCEIDHDECASSPCQNGAVCQDGIDGYSCFC-VPGYQGRHCD 184
Score = 33.1 bits (74), Expect = 1.4
Identities = 34/154 (22%), Positives = 60/154 (38%), Gaps = 15/154 (9%)
Query: 661 DALHRSGQIERGCEGPSTTCQEDSCANQGVCMQQWE----GFTCDCSMTSYSGNQCNDPG 716
D L R+ R C C C N G C+ ++ GF+C C + Y+G+ C +
Sbjct: 426 DNLSRTFYGGRDCSDILLGCTHQQCLNNGTCIPHFQDGQHGFSCLCP-SGYTGSLC-EIA 483
Query: 717 ATYIFGKSGGLILYTWPANDRPSTRSD--RLAVGFSTTVKDGILVRIDSAPGLGDFLQLH 774
T F G + W + +T+ +A+ F T +L+ F++L
Sbjct: 484 TTLSFEGDG----FLWVKSGSVTTKGSVCNIALRFQTVQPMALLL---FRSNRDVFVKLE 536
Query: 775 IEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVV 808
+ G I + + + +DG++H V
Sbjct: 537 LLSGYIHLSIQVNNQSKVLLFISHNTSDGEWHFV 570
Score = 33.1 bits (74), Expect = 1.4
Identities = 15/48 (31%), Positives = 21/48 (43%), Gaps = 1/48 (2%)
Query: 665 RSGQIERGCEGPSTTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQC 712
R G CE C D C N G+C F C C + +++G +C
Sbjct: 1286 RPGFTGEWCEKDIDECASDPCVNGGLCQDLLNKFQCLCDV-AFAGERC 1332
Score = 32.7 bits (73), Expect = 1.9
Identities = 19/71 (26%), Positives = 30/71 (42%), Gaps = 5/71 (7%)
Query: 645 CLASVDLNGRLPDLINDALH---RSGQIERGCEGPSTTCQEDSCANQGVCMQQWEGFTCD 701
C ++ ++G D + A H G CE CQ CAN C+ G++C
Sbjct: 1181 CFSNPCIHGNCSDRVA-AYHCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCL 1239
Query: 702 CSMTSYSGNQC 712
C +++G C
Sbjct: 1240 C-FGNFTGKFC 1249
Score = 32.7 bits (73), Expect = 1.9
Identities = 19/71 (26%), Positives = 36/71 (50%), Gaps = 7/71 (9%)
Query: 273 QCDSYPCKNNAVCKDGWNRFICDCTGTGYWGRTCERE------ASILSYDGSMYMKIIMP 326
+C S PC N +C+D N+F C C + G CE + + I + GS+ + +++
Sbjct: 1300 ECASDPCVNGGLCQDLLNKFQCLC-DVAFAGERCEVDLADDLISDIFTTIGSVTVALLLI 1358
Query: 327 MVMHTEAEDVS 337
+++ A V+
Sbjct: 1359 LLLAIVASVVT 1369
Score = 32.3 bits (72), Expect = 2.4
Identities = 14/42 (33%), Positives = 20/42 (47%), Gaps = 1/42 (2%)
Query: 671 RGCEGPSTTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQC 712
R C+ C D C N+ C+ + +TC C +YSG C
Sbjct: 181 RHCDLEVDECASDPCKNEATCLNEIGRYTCICP-HNYSGVNC 221
Score = 32.3 bits (72), Expect = 2.4
Identities = 10/40 (25%), Positives = 21/40 (52%)
Query: 673 CEGPSTTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQC 712
CE + C C + G+C+ ++C+C+ + ++G C
Sbjct: 259 CELNTDECASQPCLHGGLCVDGENRYSCNCTGSGFTGTHC 298
Score = 31.6 bits (70), Expect = 4.1
Identities = 31/118 (26%), Positives = 42/118 (35%), Gaps = 5/118 (4%)
Query: 596 LKVDTKVVTQVINGAKNLDLKGDLYMAGLAQGMYSNLPKLVASRDGFQGCL-ASVDLNGR 654
L++D +NGA D G Y A G + +L Q CL + ++G
Sbjct: 223 LEIDECWSQPCLNGATCQDALG-AYFCDCAPGFLGDHCELNTDECASQPCLHGGLCVDGE 281
Query: 655 LPDLINDALHRSGQIERGCEGPSTTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQC 712
N SG CE C C N C + +TC C Y+G QC
Sbjct: 282 NRYSCNCT--GSGFTGTHCETLMPLCWSKPCHNNATCEDSVDNYTCHC-WPGYTGAQC 336
>gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo
sapiens]
Length = 3014
Score = 84.7 bits (208), Expect = 4e-16
Identities = 87/366 (23%), Positives = 145/366 (39%), Gaps = 81/366 (22%)
Query: 81 PEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFAVELL 140
P+++++ + +IS F T E NGL+L+ + N K DF A+E++
Sbjct: 1449 PQSFVTFRGLRQRFHFTISLTFATQERNGLLLYN-----------GRFNEKHDFIALEIV 1497
Query: 141 DGNLYLLLDMGSGTIKVKA-TQKKANDGEWYHVDIQR------------DGRSG----TI 183
D + L G T V +DG W+ V +Q G SG +
Sbjct: 1498 DEQVQLTFSAGETTTTVAPKVPSGVSDGRWHSVQVQYYNKPNIGHLGLPHGPSGEKMAVV 1557
Query: 184 SVNSRRTPF-----------------TASGESEILDLEGDMYLGGLPENRAGLILPTELW 226
+V+ T T +G + LDL G + LGG+P LP +
Sbjct: 1558 TVDDCDTTMAVRFGKDIGNYSCAAQGTQTGSKKSLDLTGPLLLGGVPN------LPEDF- 1610
Query: 227 TAMLNYGYVGCIRDLFIDGRSKNIRQLAEMQNAAGVKSSCSRMSAKQCDSYPCKNNAVCK 286
+ N +VGC+R+L +DG KN+ + N G + C+ CD C+N C
Sbjct: 1611 -PVHNRQFVGCMRNLSVDG--KNVDMAGFIANN-GTREGCAARR-NFCDGRRCQNGGTCV 1665
Query: 287 DGWNRFICDCTGTGYWGRTCEREASILSYDGSMYMKIIMPMVMHTEA----EDVSFRFMS 342
+ WN ++C+C + G+ CE+ + P + E+ D++
Sbjct: 1666 NRWNMYLCECP-LRFGGKNCEQ-------------AMPHPQLFSGESVVSWSDLNIIISV 1711
Query: 343 QRAYGLLVATTSRDSADTLRLELDGG----RVKLMVNLDCIRINCNSSKGPETLYAGQKL 398
GL+ T DS L GG R++++ N ++ S + +G ++
Sbjct: 1712 PWYLGLMFRTRKEDS--VLMEATSGGPTSFRLQILNNYLQFEVSHGPSDVESVMLSGLRV 1769
Query: 399 NDNEWH 404
D EWH
Sbjct: 1770 TDGEWH 1775
Score = 65.1 bits (157), Expect = 3e-10
Identities = 79/379 (20%), Positives = 141/379 (37%), Gaps = 79/379 (20%)
Query: 475 LCKNGDID--YCELKARFGLRNIIADPVTFKTKSSYLSLATLQAYTSMHLFFQFKTTSPD 532
+C G+ + YCE+ R +F +S +++ L+ + F T +
Sbjct: 1429 VCPPGEYERPYCEVTTR-----------SFPPQS-FVTFRGLRQRFHFTISLTFATQERN 1476
Query: 533 GFILFNS--GDGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSDRPLNDNQWHNV------ 584
G +L+N + +DFIA+E+V + F G + ++D +WH+V
Sbjct: 1477 GLLLYNGRFNEKHDFIALEIVDEQVQLTFSAGETTTTVAPKVPSGVSDGRWHSVQVQYYN 1536
Query: 585 -------------------VITRDNSNTHSLKVDTKVVTQVINGA--------KNLDLKG 617
V+T D+ +T K + A K+LDL G
Sbjct: 1537 KPNIGHLGLPHGPSGEKMAVVTVDDCDTTMAVRFGKDIGNYSCAAQGTQTGSKKSLDLTG 1596
Query: 618 DLYMAGLAQGMYSNLPK-LVASRDGFQGCLASVDLNGRLPDLINDALHRSGQIERGCEGP 676
L + G+ NLP+ F GC+ ++ ++G+ D+ + + GC
Sbjct: 1597 PLLLGGVP-----NLPEDFPVHNRQFVGCMRNLSVDGKNVDMAGFIANNGTR--EGCAAR 1649
Query: 677 STTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQCND--PGATYIFGKSGGLILYTWPA 734
C C N G C+ +W + C+C + + G C P G+S + +W
Sbjct: 1650 RNFCDGRRCQNGGTCVNRWNMYLCECPL-RFGGKNCEQAMPHPQLFSGES----VVSWSD 1704
Query: 735 NDRPSTRSDRLAVGFSTTVKDGILVRIDSAPG-------LGDFLQLHIEQGKIGVVFNIG 787
+ + L + F T +D +L+ S L ++LQ + G V
Sbjct: 1705 LNIIISVPWYLGLMFRTRKEDSVLMEATSGGPTSFRLQILNNYLQFEVSHGPSDVE---- 1760
Query: 788 TVDISIKEERTPVNDGKYH 806
S+ V DG++H
Sbjct: 1761 ----SVMLSGLRVTDGEWH 1775
Score = 55.8 bits (133), Expect = 2e-07
Identities = 62/261 (23%), Positives = 111/261 (42%), Gaps = 31/261 (11%)
Query: 476 CKNG-------DIDYCELKARFGLRNI---IADPVTFKTKSSYLSLATLQAYTSM--HLF 523
C+NG ++ CE RFG +N + P F +S +S + L S+ +L
Sbjct: 1658 CQNGGTCVNRWNMYLCECPLRFGGKNCEQAMPHPQLFSGES-VVSWSDLNIIISVPWYLG 1716
Query: 524 FQFKTTSPDGFILFNSGDGNDFIAVELVKGYIHYVFDLGNGPNVIKGN--SDRPLNDNQW 581
F+T D ++ + G ++++ Y+ F++ +GP+ ++ S + D +W
Sbjct: 1717 LMFRTRKEDSVLMEATSGGPTSFRLQILNNYLQ--FEVSHGPSDVESVMLSGLRVTDGEW 1774
Query: 582 HNVVITRDNSNTHSLKVDTKVVTQVINGAKN-LDLKG---DLYMAGLAQGMYSNLPKLVA 637
H+++I N S +T +N D+ G L + + G S V+
Sbjct: 1775 HHLLIELKNVKEDSEMKHLVTMTLDYGMDQNKADIGGMLPGLTVRSVVVGGASE--DKVS 1832
Query: 638 SRDGFQGCLASVDLNGRLPDL----INDALHRSGQIERGCEGPSTTCQEDSCANQGVCMQ 693
R GF+GC+ V + G ++ +N+AL +++ GC+ C C C
Sbjct: 1833 VRRGFRGCMQGVRMGGTPTNVATLNMNNAL--KVRVKDGCD-VDDPCTSSPCPPNSRCHD 1889
Query: 694 QWEGFTCDCSMTSYSGNQCND 714
WE ++C C Y G C D
Sbjct: 1890 AWEDYSCVCD-KGYLGINCVD 1909
Score = 46.6 bits (109), Expect = 1e-04
Identities = 42/182 (23%), Positives = 71/182 (39%), Gaps = 23/182 (12%)
Query: 135 FAVELLDGNLYLLLDMGSGTIK-VKATQKKANDGEWYHVDIQRDGRSGTISVNSRRTPFT 193
F +++L+ L + G ++ V + + DGEW+H+ I+ + T
Sbjct: 1739 FRLQILNNYLQFEVSHGPSDVESVMLSGLRVTDGEWHHLLIELKNVKEDSEMKHLVTMTL 1798
Query: 194 ASG-ESEILDLEG--------DMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFID 244
G + D+ G + +GG E++ + G+ GC++ + +
Sbjct: 1799 DYGMDQNKADIGGMLPGLTVRSVVVGGASEDKVSV-----------RRGFRGCMQGVRMG 1847
Query: 245 GRSKNIRQLAEMQNAAGVKSSCSRMSAKQCDSYPCKNNAVCKDGWNRFICDCTGTGYWGR 304
G N+ L M NA V+ C S PC N+ C D W + C C GY G
Sbjct: 1848 GTPTNVATL-NMNNALKVRVKDGCDVDDPCTSSPCPPNSRCHDAWEDYSCVC-DKGYLGI 1905
Query: 305 TC 306
C
Sbjct: 1906 NC 1907
Score = 37.7 bits (86), Expect = 0.058
Identities = 38/173 (21%), Positives = 67/173 (38%), Gaps = 37/173 (21%)
Query: 673 CEGPSTTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQCN-------------DPGATY 719
CE C D C G C + G+TC+C ++G C G T
Sbjct: 1360 CETEIDLCYSDPCGANGRCRSREGGYTCEC-FEDFTGEHCEVDARSGRCANGVCKNGGTC 1418
Query: 720 IFGKSGGLILYTWPAN-DRP----STRS-----------------DRLAVGFSTTVKDGI 757
+ GG P +RP +TRS +++ F+T ++G+
Sbjct: 1419 VNLLIGGFHCVCPPGEYERPYCEVTTRSFPPQSFVTFRGLRQRFHFTISLTFATQERNGL 1478
Query: 758 LVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEE-RTPVNDGKYHVVR 809
L+ DF+ L I ++ + F+ G ++ + + V+DG++H V+
Sbjct: 1479 LLYNGRFNEKHDFIALEIVDEQVQLTFSAGETTTTVAPKVPSGVSDGRWHSVQ 1531
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.399
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,422,355
Number of Sequences: 37866
Number of extensions: 1765199
Number of successful extensions: 8607
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 94
Number of HSP's successfully gapped in prelim test: 96
Number of HSP's that attempted gapping in prelim test: 5732
Number of HSP's gapped (non-prelim): 2251
length of query: 1061
length of database: 18,247,518
effective HSP length: 113
effective length of query: 948
effective length of database: 13,968,660
effective search space: 13242289680
effective search space used: 13242289680
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.