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Search of human proteins with 210032790
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|210032790 hypothetical protein LOC27146 [Homo sapiens]
(1060 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|210032790 hypothetical protein LOC27146 [Homo sapiens] 2066 0.0
gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens] 377 e-104
gi|154350244 hypothetical protein LOC79632 isoform 2 [Homo sapiens] 265 2e-70
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 144 4e-34
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 142 2e-33
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 142 2e-33
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 142 2e-33
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 142 2e-33
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 142 2e-33
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 142 2e-33
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 142 2e-33
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 142 2e-33
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 138 3e-32
gi|148746195 trichohyalin [Homo sapiens] 136 9e-32
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 134 3e-31
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 131 4e-30
gi|4506751 restin isoform a [Homo sapiens] 130 9e-30
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 129 1e-29
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 129 1e-29
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 129 1e-29
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 129 2e-29
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 128 3e-29
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 128 3e-29
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 127 4e-29
gi|38044112 restin isoform b [Homo sapiens] 125 2e-28
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 125 2e-28
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 125 3e-28
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 125 3e-28
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 125 3e-28
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 125 3e-28
>gi|210032790 hypothetical protein LOC27146 [Homo sapiens]
Length = 1060
Score = 2066 bits (5354), Expect = 0.0
Identities = 1060/1060 (100%), Positives = 1060/1060 (100%)
Query: 1 MASALNSKINPPGTCQGSKADGGAGWRMDCDPQMHVKMCKKIAQLTKVIYALNTRQDEAE 60
MASALNSKINPPGTCQGSKADGGAGWRMDCDPQMHVKMCKKIAQLTKVIYALNTRQDEAE
Sbjct: 1 MASALNSKINPPGTCQGSKADGGAGWRMDCDPQMHVKMCKKIAQLTKVIYALNTRQDEAE 60
Query: 61 ASMEALREAHQEELQNAVAETKARLLQEQGCAEEEALLQRIQALESALELQKRLTEEALA 120
ASMEALREAHQEELQNAVAETKARLLQEQGCAEEEALLQRIQALESALELQKRLTEEALA
Sbjct: 61 ASMEALREAHQEELQNAVAETKARLLQEQGCAEEEALLQRIQALESALELQKRLTEEALA 120
Query: 121 ESASCRLETKERELRVEAEHAERVLTLSREMLELKADYERRLQHLTSHEATPQGRLPQES 180
ESASCRLETKERELRVEAEHAERVLTLSREMLELKADYERRLQHLTSHEATPQGRLPQES
Sbjct: 121 ESASCRLETKERELRVEAEHAERVLTLSREMLELKADYERRLQHLTSHEATPQGRLPQES 180
Query: 181 PETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYARKAEELQATYERENEAIRQAMQQSV 240
PETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYARKAEELQATYERENEAIRQAMQQSV
Sbjct: 181 PETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYARKAEELQATYERENEAIRQAMQQSV 240
Query: 241 SQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEHRGRKISDLKKYAQKLKERIQDL 300
SQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEHRGRKISDLKKYAQKLKERIQDL
Sbjct: 241 SQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEHRGRKISDLKKYAQKLKERIQDL 300
Query: 301 DVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECRGTQQTDAMKTELVSENKVLREE 360
DVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECRGTQQTDAMKTELVSENKVLREE
Sbjct: 301 DVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECRGTQQTDAMKTELVSENKVLREE 360
Query: 361 NDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEE 420
NDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEE
Sbjct: 361 NDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEE 420
Query: 421 KKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERKKLQREVEAQLEEVRKKSEKEIKQLE 480
KKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERKKLQREVEAQLEEVRKKSEKEIKQLE
Sbjct: 421 KKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERKKLQREVEAQLEEVRKKSEKEIKQLE 480
Query: 481 EEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEESPQELGRQHCSILETQDPCLKLDE 540
EEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEESPQELGRQHCSILETQDPCLKLDE
Sbjct: 481 EEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEESPQELGRQHCSILETQDPCLKLDE 540
Query: 541 TSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLGSLLKEKTSKIQRLEEDWQS 600
TSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLGSLLKEKTSKIQRLEEDWQS
Sbjct: 541 TSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLGSLLKEKTSKIQRLEEDWQS 600
Query: 601 QKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMKAQLE 660
QKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMKAQLE
Sbjct: 601 QKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMKAQLE 660
Query: 661 ASHQRALRMLEKARHQELKATEERLKKESSHSLQIQHQTHRLELQALEEKARQELQEERE 720
ASHQRALRMLEKARHQELKATEERLKKESSHSLQIQHQTHRLELQALEEKARQELQEERE
Sbjct: 661 ASHQRALRMLEKARHQELKATEERLKKESSHSLQIQHQTHRLELQALEEKARQELQEERE 720
Query: 721 RMQAQQALLLESLRQELSEQQAACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIA 780
RMQAQQALLLESLRQELSEQQAACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIA
Sbjct: 721 RMQAQQALLLESLRQELSEQQAACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIA 780
Query: 781 TEERGGPGQAGSPPGAAGQGSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRR 840
TEERGGPGQAGSPPGAAGQGSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRR
Sbjct: 781 TEERGGPGQAGSPPGAAGQGSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRR 840
Query: 841 FLEETQQAQRAREVETLRQEHRKEMQAMVADFSSAQAQLQARLAALEAELKDSGEKPGKG 900
FLEETQQAQRAREVETLRQEHRKEMQAMVADFSSAQAQLQARLAALEAELKDSGEKPGKG
Sbjct: 841 FLEETQQAQRAREVETLRQEHRKEMQAMVADFSSAQAQLQARLAALEAELKDSGEKPGKG 900
Query: 901 ASRPEDLQLIGRLQTRLKEREDIIKQLTEERRFHYAAFPSAMSHRNRSFSFNPHPGYLTP 960
ASRPEDLQLIGRLQTRLKEREDIIKQLTEERRFHYAAFPSAMSHRNRSFSFNPHPGYLTP
Sbjct: 901 ASRPEDLQLIGRLQTRLKEREDIIKQLTEERRFHYAAFPSAMSHRNRSFSFNPHPGYLTP 960
Query: 961 SMKKKKVEDVPSRVVSVPNLASYAKNFLSGDLSSRINAPPITTSPSLDPSPSCGRTYKPN 1020
SMKKKKVEDVPSRVVSVPNLASYAKNFLSGDLSSRINAPPITTSPSLDPSPSCGRTYKPN
Sbjct: 961 SMKKKKVEDVPSRVVSVPNLASYAKNFLSGDLSSRINAPPITTSPSLDPSPSCGRTYKPN 1020
Query: 1021 QSTDAKTATRTPDGETAQAKEVQQKQGSPHQEWFTKYFSF 1060
QSTDAKTATRTPDGETAQAKEVQQKQGSPHQEWFTKYFSF
Sbjct: 1021 QSTDAKTATRTPDGETAQAKEVQQKQGSPHQEWFTKYFSF 1060
>gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens]
Length = 1140
Score = 377 bits (969), Expect = e-104
Identities = 309/1141 (27%), Positives = 546/1141 (47%), Gaps = 134/1141 (11%)
Query: 24 AGWRMDCDPQMHVKMCKKIAQLTKVIYALNTRQDEAEASMEALREAHQEELQNAVAETKA 83
AG MD +MH+KM KKIAQLTKVIYALNT+ DE E++++AL++AH+EE+Q +AET+
Sbjct: 30 AGHSMDYSQEMHLKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAETRE 89
Query: 84 RLLQEQGCAEEEALLQR-IQALESALELQKRLTEEALAESASCRLETKERELRVEAEHAE 142
++LQ + EE L+R IQ LES+LE ++ ++AL E + + ++ +L EA+H +
Sbjct: 90 KILQYKSKVTEELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQ 149
Query: 143 RVLTLSREMLELKADYERRLQHL-------------------TSHEATPQGRLPQESP-- 181
R++T+SRE+ E++ +E +L+ +H Q L +
Sbjct: 150 RIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHS 209
Query: 182 ------ETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYARKAEELQATYERENEAIRQA 235
+ K+E E++ + ++ LR+E ++L +DY K + Q+ YERE + ++++
Sbjct: 210 ASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRS 269
Query: 236 MQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEHRGRKISDLKKYAQKL-- 293
Q +++L +EKE+DLRK FQ QE+ L+ + KL+ +L+ + L QKL
Sbjct: 270 -QLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQT 328
Query: 294 -----KERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRM---------------M 333
+ +Q L QL +A++ L K++ +LA A++R+ M
Sbjct: 329 ALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDLVLKASHIGM 388
Query: 334 LQECRGTQQTDAMKTELVSENKVLREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKK 393
LQ + TQ+ E +++V + LE + L E + ++ +K
Sbjct: 389 LQATQMTQEVTIKDLE-SEKSRVNERLSQLEEERAFLRSKTQSLDE---EQKQQILELEK 444
Query: 394 EASAETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAE 453
+ + ++ YE +L+ ++ + EEE L + K LE+L KH + I++V S+ +
Sbjct: 445 KVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRD 504
Query: 454 RKKLQREVEAQLEEVRKKSEKEIKQLEEE----KAALNVKLQNSLLEVLRLEEFIQQNK- 508
+KKLQ ++E Q + + E++ QL++E K L KL + E+ L++ +++++
Sbjct: 505 KKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQ 564
Query: 509 ----------TRPTGAEESPQELGRQHCSILETQDPCLKLD-ETSPRGEEYQDKLAA--- 554
+ E EL S+ ET+D L ++ E +++++ +AA
Sbjct: 565 GLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKE 624
Query: 555 EEGTSSDE------------------EERTKVLLKEGSDPQPPLGSLLKEKTSKIQRLEE 596
EE D+ + R ++ L+ D + + LL+ K + +
Sbjct: 625 EEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKKSAMSQLLQLKDREKNAARD 684
Query: 597 DWQSQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMK 656
WQ + L Q+S ++Q LE S + LQ L+ ER++L +EL+E +Q+
Sbjct: 685 SWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRH 744
Query: 657 AQLEASHQRALRMLEKARHQELKATEERLKKESSHSLQIQHQTHRLELQALEEKARQELQ 716
L+ +H A + +E+ + +E +A E L+++ S LQ HR ++ + QELQ
Sbjct: 745 KSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQ 804
Query: 717 EERERMQAQQALLLESLRQELSEQQAAC-----SGHQKDLEALQAELRA---LGRQQASS 768
R ++ + +L SLR EL+ Q AA H ++L A + EL + R+Q
Sbjct: 805 TLRFELEDEGKAMLASLRSELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQ--- 861
Query: 769 QCPGDSKDHIIATEERGGPGQAGSPPGAAGQGSGEGCGLWEENAQLQDAVRRLRAEVEQH 828
SK+HI + L +E L + + L E+E
Sbjct: 862 -----SKEHICRITDL---------QEELRHREHHISELDKEVQHLHENISALTKELEFK 907
Query: 829 QQEAQKLR----DQRRFLEETQQAQRAREVETLRQEHRKEMQAMVADFSSAQAQLQARLA 884
+E ++R Q R E+ + +E++ + +H +E M ADF+ L+ A
Sbjct: 908 GKEILRIRSESNQQIRLHEQDLNKRLEKELDVMTADHLREKNIMRADFNKTNELLKEINA 967
Query: 885 ALEAELKDSGEKPGKGASRPEDLQLIGRLQTRLKEREDIIKQLTEERRFHYAAFPSAMSH 944
AL+ L++ EK S+PED+Q+I L+ L ER+ IIK+L E+ +F+ + ++
Sbjct: 968 ALQVSLEEMEEKYLMRESKPEDIQMITELKAMLTERDQIIKKLIEDNKFYQLELVNRETN 1027
Query: 945 RNRSFSFNPHPGYLTPSMKKKKVED--VPSRVVSVPNLASYAKNFLSGDLSSRINAPPIT 1002
N+ F+ +P G + P K+KK D +R VSVPNL++ + +R++ PI
Sbjct: 1028 FNKVFNSSPTVGVINPLAKQKKKNDKSPTNRFVSVPNLSALESGGVGNGHPNRLD--PIP 1085
Query: 1003 TSPSLDPSPSCGRTYKPNQSTDAKTATRTPDGETAQAKEVQQKQGSP---HQEWFTKYFS 1059
SP D + ++ + P + A+ SP QEWF +YF+
Sbjct: 1086 NSPVHDIE------FNSSKPLPQPVPPKGPKTFLSPAQSEASPVASPDPQRQEWFARYFT 1139
Query: 1060 F 1060
F
Sbjct: 1140 F 1140
>gi|154350244 hypothetical protein LOC79632 isoform 2 [Homo sapiens]
Length = 971
Score = 265 bits (676), Expect = 2e-70
Identities = 251/1045 (24%), Positives = 465/1045 (44%), Gaps = 172/1045 (16%)
Query: 114 LTEEALAESASCRLETKERELRVEAEHAERVLTLSREMLELKADYERRLQHL-------- 165
+ ++AL E + + ++ +L EA+H +R++T+SRE+ E++ +E +L+
Sbjct: 1 MKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFE 60
Query: 166 -----------TSHEATPQGRLPQESPET--------KSEPGQGPEMQEVLLEVQRLRVE 206
+H Q L + + K+E E++ + ++ LR+E
Sbjct: 61 KDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLE 120
Query: 207 NQQLSKDYARKAEELQATYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQ 266
++L +DY K + Q+ YERE + ++++ Q +++L +EKE+DLRK FQ QE+ L+
Sbjct: 121 RKKLIEDYEGKLNKAQSFYERELDTLKRS-QLFTAESLQASKEKEADLRKEFQGQEAILR 179
Query: 267 AQVRKLEGDLEHRGRKISDLKKYAQKLK-------ERIQDLDVQLKEARQENSELKGTAK 319
+ KL+ +L+ + L QKL+ +Q L QL +A++ L K
Sbjct: 180 KTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHK 239
Query: 320 KLGEKLAVAKDRMMLQEC------------RGTQQTDAMKT-ELVSENKVLREE-NDLEA 365
++ +LA A++R+ Q + TQ T + +L SE + E + LE
Sbjct: 240 EVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEE 299
Query: 366 GNLHPQQDQSCLKECPCMKGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEEKKHLK 425
+ L E + ++ +K+ + ++ YE +L+ ++ + EEE L
Sbjct: 300 ERAFLRSKTQSLDE---EQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLN 356
Query: 426 DQLVKRLEDLVKKHTVEIKSVRSSVEAERKKLQREVEAQLEEVRKKSEKEIKQLEEE--- 482
+ K LE+L KH + I++V S+ ++KKLQ ++E Q + + E++ QL++E
Sbjct: 357 EAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELEN 416
Query: 483 -KAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAE-----------ESPQELGRQHCSILE 530
K L KL + E+ L++ +++++ AE EL S+ E
Sbjct: 417 LKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKE 476
Query: 531 TQDPCLKLD-ETSPRGEEYQDKLAA---EEGTSSDE------------------EERTKV 568
T+D L ++ E +++++ +AA EE D+ + R ++
Sbjct: 477 TKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREEL 536
Query: 569 LLKEGSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQ 628
L+ D + + LL+ K + + WQ + L Q+S ++Q LE S + LQ
Sbjct: 537 RLQHEEDKKSAMSQLLQLKDREKNAARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQ 596
Query: 629 ALKQLSDLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLEKARHQELKATEERLKKE 688
L+ ER++L +EL+E +Q+ L+ +H A + +E+ + +E +A E L+++
Sbjct: 597 QLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQK 656
Query: 689 SSHSLQIQHQTHRLELQALEEKARQELQEERERMQAQQALLLESLRQELSEQQAAC---- 744
S LQ HR ++ + QELQ R ++ + +L SLR EL+ Q AA
Sbjct: 657 HSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDLL 716
Query: 745 -SGHQKDLEALQAELRA---LGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGAAGQG 800
H ++L A + EL + R+Q SK+HI
Sbjct: 717 RHNHHQELAAAKMELERSIDISRRQ--------SKEHI---------------------- 746
Query: 801 SGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRAREVETLRQE 860
C + LQ+ +R + + +E Q L + L + + + +E+ +R E
Sbjct: 747 ----CRI----TDLQEELRHREHHISELDKEVQHLHENISALTKELEF-KGKEILRIRSE 797
Query: 861 HRKEMQAMVADFSSAQAQLQARLAALEAELKDSGEKPGKGASRPEDLQLIGRLQTRLKER 920
++++ L++ EK S+PED+Q+I L+ L ER
Sbjct: 798 SNQQIR-----------------------LEEMEEKYLMRESKPEDIQMITELKAMLTER 834
Query: 921 EDIIKQLTEERRFHYAAFPSAMSHRNRSFSFNPHPGYLTPSMKKKKVED--VPSRVVSVP 978
+ IIK+L E+ +F+ + ++ N+ F+ +P G + P K+KK D +R VSVP
Sbjct: 835 DQIIKKLIEDNKFYQLELVNRETNFNKVFNSSPTVGVINPLAKQKKKNDKSPTNRFVSVP 894
Query: 979 NLASYAKNFLSGDLSSRINAPPITTSPSLDPSPSCGRTYKPNQSTDAKTATRTPDGETAQ 1038
NL++ + +R++ PI SP D + ++ + P +
Sbjct: 895 NLSALESGGVGNGHPNRLD--PIPNSPVHDIE------FNSSKPLPQPVPPKGPKTFLSP 946
Query: 1039 AKEVQQKQGSP---HQEWFTKYFSF 1060
A+ SP QEWF +YF+F
Sbjct: 947 AQSEASPVASPDPQRQEWFARYFTF 971
Score = 67.0 bits (162), Expect = 9e-11
Identities = 126/627 (20%), Positives = 264/627 (42%), Gaps = 95/627 (15%)
Query: 51 ALNTRQDEAEASMEALREAHQEELQNAVAET-----------------------KARLLQ 87
AL ++ E E+ + A RE Q++ + V + K+R+ +
Sbjct: 233 ALLSKHKEVESELAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNE 292
Query: 88 EQGCAEEEA--LLQRIQALESA-----LELQKRLTEEALAESASCRLETKERELRVEAEH 140
EEE L + Q+L+ LEL+K++ E + E K + R+E E
Sbjct: 293 RLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEV 352
Query: 141 AERVLTLSREMLELKADYERRLQHLTSHEATPQGRLPQESPE--------TKSEPGQGPE 192
+ S+ + EL + ++ + S+ + +L + E + + Q +
Sbjct: 353 TQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQ 412
Query: 193 MQEVLLEV--QRLRVENQQLS--KDYARKAEE-------LQATYERENEAIRQAM---QQ 238
E L EV +L NQ++ +D RK+E+ L A+ + E ++ + +
Sbjct: 413 ELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKD 472
Query: 239 SVSQALWQWQEKESDLRKNFQVQESALQA-------QVRKLEGDLEHRGRKISDLKKYAQ 291
S+ + E +L + Q E + A +V K+ DLE + + +L++
Sbjct: 473 SLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTE--NLRQECS 530
Query: 292 KLKE--RIQDLD---------VQLKEARQENSELKGTAKKLGE---KLAVAKDRMMLQEC 337
KL+E R+Q + +QLK+ R++N+ KK+ + ++++ K + +Q
Sbjct: 531 KLREELRLQHEEDKKSAMSQLLQLKD-REKNAARDSWQKKVEDLLNQISLLKQNLEIQLS 589
Query: 338 RGTQQTDAMKTELVSENKVLREENDLEAGNLHPQQDQSCLKECPCMKGGT-DMQTKKEAS 396
+ ++ + E + L +E LE QQ LKE + T + + +KE
Sbjct: 590 QSQTSLQQLQAQFTQERQRLTQE--LEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQR 647
Query: 397 AETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERKK 456
A +++Q++ +L+ +K E + + ++ + L+ L + E K++ +S+ R +
Sbjct: 648 ALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASL---RSE 704
Query: 457 LQREVEAQLEEVRKKSEKEIKQLEEE-KAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAE 515
L + A ++ +R +E+ + E + ++++ + S + R+ + ++ + R
Sbjct: 705 LNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHIS 764
Query: 516 ESPQELGRQHCSILETQDPCLKLDETSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSD 575
E +E+ H +I E +G+E ++ +E EE + L S
Sbjct: 765 ELDKEVQHLHENI------SALTKELEFKGKEIL-RIRSESNQQIRLEEMEEKYLMRESK 817
Query: 576 PQ-----PPLGSLLKEKTSKIQRLEED 597
P+ L ++L E+ I++L ED
Sbjct: 818 PEDIQMITELKAMLTERDQIIKKLIED 844
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 144 bits (363), Expect = 4e-34
Identities = 218/1010 (21%), Positives = 425/1010 (42%), Gaps = 142/1010 (14%)
Query: 37 KMCKKIAQLTKVIYALNTRQDEAEASMEALREAHQEELQNAVAETKARLLQEQGCAEEE- 95
++ +K+ +L + Q EA+A + L + E Q A K R+ QE+ +E+
Sbjct: 647 ELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATE--KERVAQEKDQLQEQL 704
Query: 96 -ALLQRIQALESALELQKRLTEEALAESASCRLETKERELRVEAEHAERVLTLSREMLEL 154
AL + ++ + +LE +KR +AL E C E K + +H L E
Sbjct: 705 QALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGR 764
Query: 155 KADYERRLQHL-TSHEATPQGRLPQESPETKSEPGQGPEMQEVLLEVQRLRV---ENQQL 210
K E RLQ L +H+A + + + ++ E ++++ EV R ++QQ
Sbjct: 765 KG-LEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQE 823
Query: 211 SKDYARKAEELQATYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVR 270
Y +E T + E E RQ +Q++ +EK + + + ++Q S Q ++
Sbjct: 824 EAQYGAMFQEQLMTLKEECEKARQELQEA--------KEKVAGIESHSELQISRQQNELA 875
Query: 271 KLEGDLEHRGRKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKD 330
+L +L +++ + + AQKL + + L ++ +E + L+ +K GE+ A
Sbjct: 876 ELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASR 935
Query: 331 RMM-------------LQECRGTQ-------------QTDAMKTELVSENKVLREENDLE 364
++ L+E +G Q + + M EL L E +
Sbjct: 936 ELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQ 995
Query: 365 AGNLHPQQDQSCLKECPCMKGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEE---- 420
Q+ + + D+ +K A AE E M+ Q + ++++ T +E
Sbjct: 996 QEERGQQEREVARLTQERGRAQADLALEKAARAELE-MRLQNALNEQRVEFATLQEALAH 1054
Query: 421 ---KKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERKKLQREVEAQLEEVRKKSEK--- 474
+K KDQ + +L L E++ +R +V+ +++L ++ + +SE
Sbjct: 1055 ALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGR 1114
Query: 475 ------EIKQLEEEKAALNVKLQNSLLEVLRLEEFIQQNK-----------TRPTGAEES 517
+++ L E + L + Q + LE ++ + T EE
Sbjct: 1115 TEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEK 1174
Query: 518 PQELGRQHCSILETQDPCL----KLDETSPRGEEYQDKLA-----AEEGTS---SDEEE- 564
QELG ++ Q K+ + S +E++ ++A AE S S EEE
Sbjct: 1175 AQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEV 1234
Query: 565 ---RTKVLLKEGSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQQALEQCTS 621
+VL KEG + L L+ ++ K Q+LEE + LQA+ + + +S
Sbjct: 1235 SILNRQVLEKEGESKE--LKRLVMAESEKSQKLEE----RLRLLQAETASNSARAAERSS 1288
Query: 622 NYREDLQALKQLSDLER---EKLQRELQETTQQNHAMKAQLEASHQRALRMLEKARHQEL 678
RE++Q+L++ ++ +R E L++EL ++ + +L+A ++ + + +L
Sbjct: 1289 ALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQL 1348
Query: 679 KATEERLKKESSHSLQIQHQTHRLELQ--ALEEKARQELQEERERMQAQQALLLESLRQ- 735
+ T + S L +H +L+ + A E++ R+EL++ ++ +A LL + R+
Sbjct: 1349 EHTSTQALV--SELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQREL 1406
Query: 736 -ELSEQQAACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGS-- 792
EL + + ++ + L+AE + Q + + K H + EE G G+ +
Sbjct: 1407 GELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLK-----KAHGLLAEENRGLGERANLG 1461
Query: 793 ----------------PPGAAGQGSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLR 836
AA + E L E + Q R L +++ K+
Sbjct: 1462 RQFLEVELDQAREKYVQELAAVRADAE-TRLAEVQREAQSTARELEVMTAKYEGAKVKVL 1520
Query: 837 DQR-RFLEETQQ-AQRAREVETLRQEHRKEMQAM---VADFSSAQAQLQARLAALEAELK 891
++R RF EE Q+ + ++E ++E K+++ + +AD A Q +L A++A+
Sbjct: 1521 EERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQ-- 1578
Query: 892 DSGEKPGKGASRPEDLQL-IGRLQTRLKERE---DIIKQLTEERRFHYAA 937
G+ + LQ + LQ +L ++E + K E+ + HY A
Sbjct: 1579 -----GGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDA 1623
Score = 123 bits (308), Expect = 1e-27
Identities = 226/998 (22%), Positives = 404/998 (40%), Gaps = 165/998 (16%)
Query: 37 KMCKKIAQLTKVIYALNTRQDEAEASMEALREAHQEELQNAVAETKARLLQEQGCAEEEA 96
++ ++A LT + LN + + + L++ +E+ Q +A+T LQ+Q A +
Sbjct: 495 RLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEK-QAQLAQT----LQQQEQASQ-G 548
Query: 97 LLQRIQALESALELQKRLTEEALAESASCRLETKERELRVEAEHAERVLTLSREMLELKA 156
L +++ L S+L+ + E+ L E A E++ +HA+++ T + E
Sbjct: 549 LRHQVEQLSSSLKQK----EQQLKEVA-------EKQEATRQDHAQQLATAAEEREASLR 597
Query: 157 DYERRLQHLTSHEATPQGRLPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYAR 216
+ + L+ L + E +L + + Q + + QR + E +R
Sbjct: 598 ERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAE-------LSR 650
Query: 217 KAEELQATYERENEAIRQAMQQ-------------------SVSQALWQWQEKESDLRKN 257
K EELQA E + +A Q V+Q Q QE+ L+++
Sbjct: 651 KVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKES 710
Query: 258 FQVQESALQAQVRKLEGDLEHRGRKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGT 317
+V + +L+ + R+ LE + R IS+LK + L E+ + +L+E R L+
Sbjct: 711 LKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEAR 770
Query: 318 AKKLGEKLAVAKD--RMMLQECRGTQQTDAMKTE-LVSENKVLRE------ENDLEAGNL 368
++LGE + R L E Q T + E LV E RE + + + G +
Sbjct: 771 LQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAM 830
Query: 369 HPQQDQSCLKECPCMKGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEEKKHLKDQL 428
+Q + +EC K ++Q KE A E +L+ + Q E + H L
Sbjct: 831 FQEQLMTLKEECE--KARQELQEAKEKVAGIE-----SHSELQISRQQNELAELHA--NL 881
Query: 429 VKRLEDLVKKHTVEIKSVRSSVEAERKKLQREVEAQLEEVRKKSEKEIKQLEEEKAALNV 488
+ L+ + +K E +KL ++ + L+E + KE+ +LE
Sbjct: 882 ARALQQVQEK------------EVRAQKLADDL-STLQEKMAATSKEVARLETLVRKAGE 928
Query: 489 KLQNSLLEVLRLEEFIQQNKTRPTGAEESPQELGRQHCSILETQDPCLKLD-ETSPRGEE 547
+ + + E+++ E + +P EE + GRQ CS TQ ++ E G E
Sbjct: 929 QQETASRELVK--EPARAGDRQPEWLEE---QQGRQFCS---TQAALQAMEREAEQMGNE 980
Query: 548 YQD-KLAAEEGTSSDEEER---TKVLLKEGSDPQPPLGSLLKEKTSKIQRLEEDWQSQKA 603
+ + A E +EER + + + + L EK ++ + LE Q+
Sbjct: 981 LERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAE-LEMRLQNALN 1039
Query: 604 KLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQ--RELQETTQQNHAMKAQLEA 661
+ + + + +Q+AL + Q L +L LE +++ EL++T +Q A+ E
Sbjct: 1040 EQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEK 1099
Query: 662 SHQRALRMLEKA--RHQELKATEERLKKESSHSLQIQHQTHRLELQALEEKARQELQEER 719
H +A R + E L+ E S L+ Q Q + + +LE E
Sbjct: 1100 EHASGSGAQSEAAGRTEPTGPKLEALRAEVS-KLEQQCQKQQEQADSLERSLEAERASRA 1158
Query: 720 ERMQAQQAL--LLESLRQELSEQQAACSGHQKDLEALQAELR-------------ALGRQ 764
ER A + L LE QEL Q+A + Q++L A + +++ A GRQ
Sbjct: 1159 ERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQ 1218
Query: 765 QASS--------------------QCPGDSKD--HIIATEERGGPGQAGSPPGAAGQGSG 802
+A + G+SK+ ++ E + +
Sbjct: 1219 EAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETAS 1278
Query: 803 EGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRARE--------- 853
E ++ L++ V+ LR E E+ + ++ LR E T QA+RA E
Sbjct: 1279 NSARAAERSSALREEVQSLREEAEKQRVASENLRQ-----ELTSQAERAEELGQELKAWQ 1333
Query: 854 ---------VETLRQEHRKEMQAMVADFSSAQ---AQLQARLAALEAELKDSGE--KPGK 899
+ TL+ EH QA+V++ A+ QLQA AA E ++ E K
Sbjct: 1334 EKFFQKEQALSTLQLEH-TSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAA 1392
Query: 900 GASRPE------DLQLIGRLQTRLKEREDIIKQLTEER 931
G R E +L + L+ ++ E+E +QL E+
Sbjct: 1393 GGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEK 1430
Score = 116 bits (290), Expect = 1e-25
Identities = 196/897 (21%), Positives = 368/897 (41%), Gaps = 127/897 (14%)
Query: 64 EALREAHQEELQNAVAETKARLLQEQGCAEEEALLQRIQALESALELQKRLTEEALAESA 123
E L++ + + + + K L E E L +++ S L+ + E E +
Sbjct: 294 ETLKQCQDLKTEKSQMDRKINQLSE----ENGDLSFKLREFASHLQQLQDALNELTEEHS 349
Query: 124 SCRLETKERELRVEAEHAERVLTLSREMLELKADY-ERRLQHLTSHEATPQGRLPQESPE 182
E E++ ++E E + + ++ LE K + + +L L H + Q PQE E
Sbjct: 350 KATQEWLEKQAQLEKELSAALQ--DKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGE 407
Query: 183 TKSEPGQGPEMQEVLLEVQRLRVENQQLSK-----DYARKAEELQATYER----ENEAIR 233
G +++ + E L N QL + R +E + ER E +
Sbjct: 408 VL---GDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQL 464
Query: 234 QAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEHRGRKISDLKKYAQKL 293
++ + ++ + + +L + Q + L AQV L +L I + L
Sbjct: 465 SSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGL 524
Query: 294 KERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECRGTQQTDAMKTELVSE 353
K++ ++ QL + Q+ + + E+L+ +Q + E+ +
Sbjct: 525 KQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLS-----------SSLKQKEQQLKEVAEK 573
Query: 354 NKVLREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEASAETEYMKQQYEEDLRKI 413
+ R+++ + +++ S + +K ++ +K A E + Q + R
Sbjct: 574 QEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDS 633
Query: 414 KHQTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERKKLQREVEAQLEEVRKKSE 473
+ + + K +L +++E+L ++ VE R++ Q E +AQ+ E+ +
Sbjct: 634 AQTSVTQAQREKAELSRKVEEL-----------QACVETARQE-QHEAQAQVAELELQLR 681
Query: 474 KEIKQLEEEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEESPQELGRQHCSILETQD 533
E ++ E++ K Q L+E +Q K + S +E R+ LE Q
Sbjct: 682 SEQQKATEKERVAQEKDQ--------LQEQLQALKESLKVTKGSLEEEKRRAADALEEQQ 733
Query: 534 PCLKLDETSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLGSLLKEKTSKIQR 593
C+ +L AE + ++ +R + L+E + K +++Q+
Sbjct: 734 RCI-------------SELKAETRSLVEQHKRERKELEEERAGR-------KGLEARLQQ 773
Query: 594 LEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQRELQETTQQNH 653
L E Q++ L+ ++++ A S E Q +K+++ RE+ + QE Q
Sbjct: 774 LGEAHQAETEVLRRELAEAMAAQHTAES---ECEQLVKEVA-AWRERYEDSQQEEAQYGA 829
Query: 654 AMKAQLEASHQRALRMLEKARHQELKATEERLKKESSHS-LQIQHQTHRL-ELQALEEKA 711
+ QL + EKAR QEL+ +E++ SHS LQI Q + L EL A +A
Sbjct: 830 MFQEQLMTLKEEC----EKAR-QELQEAKEKVAGIESHSELQISRQQNELAELHANLARA 884
Query: 712 RQELQEERERMQAQQALLLESLRQELSEQQAACSGHQKDLEALQAELRALGRQQASSQCP 771
Q++QE+ R Q L +LS Q + K++ L+ +R G QQ +
Sbjct: 885 LQQVQEKEVRAQ--------KLADDLSTLQEKMAATSKEVARLETLVRKAGEQQET---- 932
Query: 772 GDSKDHIIATEERGGPGQAGSPPGAAGQGSGEGCGLWEENAQLQDAVRRLRAEVEQHQQE 831
+ ++ R G Q P Q + C Q A++ + E EQ E
Sbjct: 933 --ASRELVKEPARAGDRQ---PEWLEEQQGRQFC-------STQAALQAMEREAEQMGNE 980
Query: 832 AQKLRD---QRRFLEETQQAQRAREVETLRQEHRKEMQAMVADFSSAQAQLQARL----- 883
++LR + + ++ ++ Q+ REV L QE R QA +A +A+A+L+ RL
Sbjct: 981 LERLRAALMESQGQQQEERGQQEREVARLTQE-RGRAQADLALEKAARAELEMRLQNALN 1039
Query: 884 ------AALEAELKDS-GEKPGKGASRPEDLQLIGRLQTRLKEREDI---IKQLTEE 930
A L+ L + EK GK E +L G ++KE E++ +KQL E+
Sbjct: 1040 EQRVEFATLQEALAHALTEKEGKD---QELAKLRGLEAAQIKELEELRQTVKQLKEQ 1093
Score = 115 bits (287), Expect = 3e-25
Identities = 200/881 (22%), Positives = 361/881 (40%), Gaps = 125/881 (14%)
Query: 60 EASMEALREAHQEELQNAVAETKARLLQEQGCAEEEALLQRIQALESALELQKRLTEEAL 119
+A+++A+ E E++ N + +A L++ QG +EE Q + RLT+E
Sbjct: 964 QAALQAM-EREAEQMGNELERLRAALMESQGQQQEERGQQEREVA--------RLTQERG 1014
Query: 120 AESASCRLETKER-ELRVEAEHAERVLTLSREMLELKADYERRLQHLTSHEATPQGRLPQ 178
A LE R EL + ++A E+R++ T EA +
Sbjct: 1015 RAQADLALEKAARAELEMRLQNALN---------------EQRVEFATLQEALAHALTEK 1059
Query: 179 ESPETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYARKAEELQATYERENEAIRQAMQQ 238
E + + +G E ++ E++ LR +QL + A+K +E + ++EA + +
Sbjct: 1060 EGKDQELAKLRGLEAAQIK-ELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRT--E 1116
Query: 239 SVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEHRGRKISDLKKYAQKLKERIQ 298
L + + S L + Q Q+ + R LE + R + S L+ +L+E+ Q
Sbjct: 1117 PTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQ 1176
Query: 299 DLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECRGTQQTDAMKTELVSENKVLR 358
+L EL K+ + + A+D Q RG Q+ + K L+S
Sbjct: 1177 ELGHSQSALASAQRELAAFRTKVQDH-SKAEDEWKAQVARGRQEAER-KNSLISSL---- 1230
Query: 359 EENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTE 418
+++ S L K G + K+ AE+E Q+ EE LR ++ +T
Sbjct: 1231 ------------EEEVSILNRQVLEKEGESKELKRLVMAESE-KSQKLEERLRLLQAETA 1277
Query: 419 EEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAER---KKLQREVEAQLEEVRKKSEK- 474
++ E E++S+R E +R + L++E+ +Q E + ++
Sbjct: 1278 SNSARAAERSSALRE--------EVQSLREEAEKQRVASENLRQELTSQAERAEELGQEL 1329
Query: 475 ---EIKQLEEEKAALNVKLQNS-----LLEVLRLEEFIQQNKTRPTGAE--------ESP 518
+ K ++E+A ++L+++ + E+L + QQ + AE +S
Sbjct: 1330 KAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSK 1389
Query: 519 QELGRQHCSILETQDPCLKLDETSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSDPQP 578
Q G +L Q +L E P + K+A E+ERT L+
Sbjct: 1390 QAAGGLRAELLRAQR---ELGELIP----LRQKVA--------EQERTAQQLRAEKASYA 1434
Query: 579 PLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLER 638
S+LK K + E ++A L Q +++ L+Q Y ++L A++ ++
Sbjct: 1435 EQLSMLK-KAHGLLAEENRGLGERANLGRQFLEVE--LDQAREKYVQELAAVRADAETRL 1491
Query: 639 EKLQRELQETTQQNHAMKAQLEASHQRAL--RMLEKARHQELKATEERLK---------- 686
++QRE Q T ++ M A+ E + + L R + Q+L A E+L+
Sbjct: 1492 AEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQV 1551
Query: 687 KESSHSLQIQHQTHRLELQALEEKARQ--ELQEERERMQAQQALLLESLRQELSEQQAAC 744
+E S L Q +++ Q L+ Q E Q+E +R+QAQ L L+ +LS+++ A
Sbjct: 1552 EELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQ----LNELQAQLSQKEQAA 1607
Query: 745 SGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIA--TEERGGPGQAGSPPGAAGQGSG 802
++ +E + A +Q Q S + + E R + G AG +
Sbjct: 1608 EHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTK 1667
Query: 803 EGCGLWEENAQ-LQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRAREVETLRQEH 861
E E+ + L VR L A+V Q+ LRD +F T A ++RE + Q
Sbjct: 1668 EA----EQTCRHLTAQVRSLEAQVAHADQQ---LRDLGKFQVAT-DALKSREPQAKPQ-- 1717
Query: 862 RKEMQAMVADFSSAQAQLQARLAALEAELKDSGEKPGKGAS 902
++ D S + + + L D PG+ AS
Sbjct: 1718 -LDLSIDSLDLSCEEGTPLSITSKLPRTQPDGTSVPGEPAS 1757
Score = 92.8 bits (229), Expect = 2e-18
Identities = 161/689 (23%), Positives = 303/689 (43%), Gaps = 83/689 (12%)
Query: 285 DLKKYAQKLKERIQDLDVQ-LKEARQENSELKGT-AKKLGEKLAVAKDRMM-LQECRGTQ 341
+L + + K I+ L++Q + + N+ L G+ A +G+ L + +M L++ +
Sbjct: 167 ELSPPSHQAKREIRFLELQKVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLKKQLADE 226
Query: 342 QTDAMKTEL-VSENKVLREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEASAETE 400
+++ + EL ++EN+ L E D + + + D+ L + + +E + E
Sbjct: 227 RSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNE 286
Query: 401 YMKQQYEEDLRKIKH-QTEEEKKHLK-DQLVKRLEDLVKK------HTVEIKSVRSSVEA 452
+ + E L++ + +TE+ + K +QL + DL K H +++ + +
Sbjct: 287 SLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTE 346
Query: 453 ERKKLQRE---VEAQLEEVRKKSEKEIKQLEEEKAALNVKLQNSLLEVLRLEEFIQQNKT 509
E K +E +AQLE+ + ++ K LEE+ L KL +LEE + Q +
Sbjct: 347 EHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLS-------QLEEHLSQLQD 399
Query: 510 RPTGAEESPQELG--------RQHCSILETQDPCLK----LDETSPRGEEYQDKLAAEEG 557
P +E + LG +Q + L + L+ + ET RG++ + KL AE G
Sbjct: 400 NPP--QEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETE-RGQQ-EAKLLAERG 455
Query: 558 TSSDEEERTKVLLKEGSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQQALE 617
+E+++ L+ +D Q + +L + K + LE+ Q+ A+L AQV+ + L
Sbjct: 456 HFEEEKQQLSSLI---TDLQSSISNLSQAK----EELEQASQAHGARLTAQVASLTSELT 508
Query: 618 QCTSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLEKARHQE 677
+ ++ Q L L +EK Q +L +T QQ Q +AS + LR +
Sbjct: 509 TLNATIQQQDQELAGLKQQAKEK-QAQLAQTLQQ------QEQAS--QGLRHQVEQLSSS 559
Query: 678 LKATEERLKKESSHSLQIQHQTHRLELQALEEKARQELQE------ERERMQAQQALLLE 731
LK E++L KE + + Q H +L E+ L+E + E ++ ++A LE
Sbjct: 560 LKQKEQQL-KEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLE 618
Query: 732 SLRQELSEQQAACSGHQKDLEALQAELRALGRQQASSQ-CPGDSKDHIIATEERGGPGQA 790
L+Q+L A Q + Q E L R+ Q C ++ E + +
Sbjct: 619 ILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQE--QHEAQAQVAEL 676
Query: 791 GSPPGAAGQGSGEGCGLWEENAQLQDAVRRLRAEV--------EQHQQEAQKLRDQRRFL 842
+ Q + E + +E QLQ+ ++ L+ + E+ ++ A L +Q+R +
Sbjct: 677 ELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCI 736
Query: 843 EETQQAQRAREVETLRQEHRKEMQAMVADFSSAQAQLQARLAALEAELKDSGEKPGKGAS 902
E + R+ VE ++E RKE++ A +A+LQ A +AE +
Sbjct: 737 SELKAETRSL-VEQHKRE-RKELEEERAGRKGLEARLQQLGEAHQAETE---------VL 785
Query: 903 RPEDLQLIGRLQTRLKEREDIIKQLTEER 931
R E + + T E E ++K++ R
Sbjct: 786 RRELAEAMAAQHTAESECEQLVKEVAAWR 814
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 142 bits (358), Expect = 2e-33
Identities = 228/975 (23%), Positives = 427/975 (43%), Gaps = 117/975 (12%)
Query: 55 RQDEAEASMEALREAHQEEL----QNAVAETKARLLQEQGC------AEEEALLQRIQ-- 102
R++EA + + + QEEL Q++ AE +A+ Q + EEE + R+Q
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1462
Query: 103 -------ALESALELQKRLTEEALAESASCRLETKERELRVEAEHAERVLTLSREMLELK 155
E L+ + EEA A+ + E + +V+ E + +K
Sbjct: 1463 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1522
Query: 156 ADYERRLQHLTSHEATPQGRLPQESPETK---SEPGQGPEMQEVLLEVQR-LRVENQQLS 211
A+ E + + +A + RL E E + +E + ++Q L QR E Q
Sbjct: 1523 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1582
Query: 212 KDYARKAEELQATYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRK 271
+A K +L+ + + E+ A+ Q +++ +A Q Q A +A+ +
Sbjct: 1583 ASFAEKTAQLERSLQEEHVAVAQLREEAERRA---------------QQQAEAERAR-EE 1626
Query: 272 LEGDLEHRGRKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLG--EKLAVAK 329
E +LE K ++ + + +E Q + EA ++ E + A++ G E+ AV +
Sbjct: 1627 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1686
Query: 330 DRMMLQECRGTQQ--TDAMKTELVSENKVLREENDLEAGNLHPQQDQSCLKECPCMKGGT 387
+ QE +Q + L +E +++R + E G QQ Q +E ++
Sbjct: 1687 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE---QQRQLLEEELARLQREA 1743
Query: 388 DMQTKKEASAETEYMKQQYE-EDLRKIKHQTEEEKKHLKDQLVKRLE-DLVKKHTVEIKS 445
T+K E E K + E E L K + EEE + ++ +RLE + + + ++
Sbjct: 1744 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1803
Query: 446 VRSSVEAERKKLQREVEAQLEEVRKKSEKEIKQLEEEKAALNVKLQNSLLEVLRLEEFIQ 505
R AE K QR++ A+ + R+++E E + L E+ AA+ + + L+E
Sbjct: 1804 ARLRALAEEAKRQRQL-AEEDAARQRAEAE-RVLAEKLAAIGEATRLKTEAEIALKEKEA 1861
Query: 506 QNKTRPTGAEESPQELGRQHCSILETQDPCLKLDETSPRGEEYQDKLAAEEGTSSDEEER 565
+N+ AE+ + R LE Q K D +++LA S E ER
Sbjct: 1862 ENERLRRLAEDEAFQRRR-----LEEQAAQHKAD--------IEERLAQLRKASDSELER 1908
Query: 566 TKVLLKEGSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQ-QALEQCTSNYR 624
K L+++ + ++E+ ++ E + KA+L+ ++ +++ A + S +
Sbjct: 1909 QKGLVEDTLRQR----RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ 1964
Query: 625 EDLQALKQLS-DLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLE--KARHQELKAT 681
+L+A +Q E E+ +RE +E Q++ A + + + AL +E KA+ +E +
Sbjct: 1965 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRL 2024
Query: 682 EERLKKESSHSLQIQHQTHRLELQALEEKAR----QELQEERERMQAQQALLLESLRQEL 737
ER ++ES+ LQ+ + + LQA EEKA Q+ ++E ++ Q+ +L+ LR E
Sbjct: 2025 RERAEQESARQLQLAQEAAQKRLQA-EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2083
Query: 738 SEQQAACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGAA 797
+ A EA +A ++A R+ A S+ + + + + E + A
Sbjct: 2084 EAARRAAE------EAEEARVQA-EREAAQSRRQVEEAERLKQSAEEQAQAR------AQ 2130
Query: 798 GQGSGEGCGLWEENAQLQDAVRRLRAE---VEQHQQEAQKLRDQRRFLEET--QQAQRAR 852
Q + E E Q+A RR +AE + Q Q ++ ++F E+T Q+AQ +
Sbjct: 2131 AQAAAEKLRKEAE----QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2186
Query: 853 EVETLR-----QEHRK-----EMQAMVADFSSA---QAQLQARLAALEAELKDSGEKPGK 899
E+ TLR +H+K E+Q + A+ + A ++Q++ L ++ ++++ + K
Sbjct: 2187 ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL--K 2244
Query: 900 GASRPEDLQLIGR----LQTRLKEREDIIKQLTEERRFHYAAFPSAMSHRNRSFSFNPHP 955
E+ LI R Q L+E + +KQ+ EE A A R +
Sbjct: 2245 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2304
Query: 956 GYLTPSMKKKKVEDV 970
L M K+K++ V
Sbjct: 2305 RALAEKMLKEKMQAV 2319
Score = 138 bits (348), Expect = 2e-32
Identities = 222/971 (22%), Positives = 413/971 (42%), Gaps = 141/971 (14%)
Query: 47 KVIYALNTRQDEAEASMEALREAHQEELQNAVAETKARLLQEQGCAEEEALLQRIQALES 106
+ + AL + +AE + LR+A E + + + L Q AE E +R E
Sbjct: 1533 RALQALEELRLQAEEAERRLRQAEVERAR----QVQVALETAQRSAEAELQSKRASFAEK 1588
Query: 107 ALELQKRLTEEALAESASCRLETKER-ELRVEAEHAERVLTLSREMLELKADYERRLQHL 165
+L++ L EE +A A R E + R + + EAE A E +LKA+ RL+ L
Sbjct: 1589 TAQLERSLQEEHVA-VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR-L 1646
Query: 166 TSHEATPQGRLPQESPETKSEPGQGPEMQEVLLEVQRLR---VENQQLSKDYARKAEELQ 222
+ E Q L Q E + E + + E Q +R + Q+L K Q
Sbjct: 1647 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1706
Query: 223 ATYERENEAIR--------QAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEG 274
E E IR + +Q + + L + Q + + + Q E+ L ++E
Sbjct: 1707 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1766
Query: 275 DLEHRGRKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAK----- 329
L + R + + ++K K+R++ + +E +E + L+ A++ + +A+
Sbjct: 1767 LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR 1826
Query: 330 -----DRMMLQECRGTQQTDAMKTEL-------VSENKVLREENDLEAGNLHPQQDQSCL 377
+R++ ++ + +KTE +EN+ LR + EA ++Q+
Sbjct: 1827 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ 1886
Query: 378 KECPCMKGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVK------- 430
+ + Q +K + +E E K E+ LR+ + Q EEE LK K
Sbjct: 1887 HKADIEE--RLAQLRKASDSELERQKGLVEDTLRQ-RRQVEEEILALKASFEKAAAGKAE 1943
Query: 431 ----------RLEDLVK-KHTVEIKSVRS-SVEAERKKLQREVEAQLEEVRKKSEKEIKQ 478
ED ++ K E+++ R + AE ++ +RE E E V+K E +
Sbjct: 1944 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE---ERVQKSLAAEEEA 2000
Query: 479 LEEEKAALN--VKLQNSLLEVLRLEEFIQQNKTRPTG-AEESPQE--LGRQHCSILETQD 533
+ KAAL +L+ + E RL E +Q R A+E+ Q+ + Q
Sbjct: 2001 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2060
Query: 534 PCLKLDETSPRGEEYQDKLAAEEGT---SSDEEERTKVLLKEGSDPQPPLGSLLKEKTSK 590
+L +T + + D+L E +++E E +V ++ + E+ +
Sbjct: 2061 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV----QAEREAAQSRRQVEEAER 2116
Query: 591 IQRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQAL---KQLSDLEREKLQRELQE 647
+++ E+ +A+ QA ++++ EQ + + QA KQ +D E EK ++ ++
Sbjct: 2117 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2176
Query: 648 TTQQNHAMKAQLEASHQRALRMLEKARHQELKATEE--RLKKESSHSLQIQHQTH----- 700
T +Q KAQ+E LE+ HQ+ EE RLK E++ + + + Q
Sbjct: 2177 TLRQ----KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2232
Query: 701 -RLELQALEE-KARQE-----------------LQEERERMQ--AQQALLLESLRQELSE 739
R++++ L + KAR E LQEE E+M+ A++A L QE +
Sbjct: 2233 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2292
Query: 740 QQAACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGAAGQ 799
+ ++DL A+ RAL + K+ + A +E A +
Sbjct: 2293 LRQLA---EEDL----AQQRALAEKML--------KEKMQAVQE-------------ATR 2324
Query: 800 GSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRAREVETLRQ 859
E L ++ Q+ RRL+ E +Q AQ+L ++ + + T +A+R R++E +
Sbjct: 2325 LKAEAELLQQQKELAQEQARRLQ---EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2381
Query: 860 EHRKEMQAMVADFSSAQAQLQARLAALEAELKDSGEKPGK-GASRPEDLQLIGRLQTRLK 918
R +++ VA+ S AQA+ + + ++ GEK + + E + L+ L+ + +
Sbjct: 2382 AERLKLR--VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ 2439
Query: 919 EREDIIKQLTE 929
+ + ++L E
Sbjct: 2440 QSDHDAERLRE 2450
Score = 128 bits (322), Expect = 2e-29
Identities = 206/918 (22%), Positives = 397/918 (43%), Gaps = 132/918 (14%)
Query: 58 EAEASMEALREAHQEELQNAVAETKA---RLLQEQGCAE----EEALLQRIQALESALEL 110
EAE +++ +EA E L+ +AE +A R L+EQ EE L Q +A +S LE
Sbjct: 1851 EAEIALKE-KEAENERLRR-LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1908
Query: 111 QKRLTEEAL-------------------AESASCRLETKERELRVEAEHAERVLTLSREM 151
QK L E+ L A + LE + +R AE R S+E
Sbjct: 1909 QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR----SKEQ 1964
Query: 152 LELKADYERRLQHLTSHEATPQGRLPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLS 211
EL+A +R+L Q+S + E + + + L EV+RL+ + ++
Sbjct: 1965 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR--QRKAALEEVERLKAKVEEAR 2022
Query: 212 KDYARKAEELQATYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRK 271
+ R +E + EA ++ +Q + Q+KE +L++ Q ++S L +
Sbjct: 2023 RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD----Q 2078
Query: 272 LEGDLEHRGRKISDLK-------KYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEK 324
L G+ E R + + + A + + ++++ + +LK++ +E ++ + A+ EK
Sbjct: 2079 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-RLKQSAEEQAQARAQAQAAAEK 2137
Query: 325 LAVAKDRMMLQECRGTQQTDAMKTELVSENKVLREENDLEAG-NLHPQQDQSCLKECPCM 383
L + +Q A + + +E LR++ +A H + + L++ +
Sbjct: 2138 LR-----------KEAEQEAARRAQ--AEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2184
Query: 384 KGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEI 443
+ ++ T + ET++ K +E+L+++K + E + + Q+ + L V+ E+
Sbjct: 2185 E--QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ-RSQVEEELFS-VRVQMEEL 2240
Query: 444 KSVRSSVEAERKKLQREVEAQLEEVRKKSEKEIKQLEEEKAALNVKLQNSL-LEVLRLEE 502
+++ +EAE + L + + ++ +++KQ+ EE A L+V Q + L L E+
Sbjct: 2241 SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2300
Query: 503 FIQQNKTRPTGAEESPQELGRQHCSILETQDPCLKLDETSPRGEEYQDKLAAEEGT--SS 560
QQ +E Q + Q + L+ + L + Q +LA E+
Sbjct: 2301 LAQQRALAEKMLKEKMQAV--QEATRLKAEAELL----------QQQKELAQEQARRLQE 2348
Query: 561 DEEERTKVLLKEGSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQ-AQVSQMQQALEQC 619
D+E+ + L +E Q L + + ++LE ++++ KL+ A++S+ Q E
Sbjct: 2349 DKEQMAQQLAEETQGFQRTL------EAERQRQLEMSAEAERLKLRVAEMSRAQARAE-- 2400
Query: 620 TSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLEKARHQ--E 677
ED Q ++ ++ EKL R + TQ+ + LE Q++ E+ R E
Sbjct: 2401 -----EDAQRFRKQAEEIGEKLHRT-ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2454
Query: 678 LKATEERLKKESSHSLQIQHQTHRLELQALE-EKARQELQEERERMQAQQALLLESLRQE 736
L+ +E+L++E+ LQ++ + E+Q ++ E+ QE Q ++ +++ LL+ R
Sbjct: 2455 LEREKEKLQQEAK-LLQLKSE----EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF- 2508
Query: 737 LSEQQAACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGA 796
+ +++A +D A +LR QQ Q + ++A+ E Q + G
Sbjct: 2509 IEQEKAKLEQLFQDEVAKAQQLRE--EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2566
Query: 797 AGQGSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRAREVET 856
+ +LQ ++ R + E +E Q+LR+Q + LEE +A A E
Sbjct: 2567 R-----------RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2615
Query: 857 LRQEHRKEMQAMVADFSSAQAQLQARLAALEAELKDSGEKPGKGASR--------PEDLQ 908
+ A + + L A E E G + A R E+LQ
Sbjct: 2616 TASQ-----VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQ 2670
Query: 909 LIGRLQTRLKE---REDI 923
+ + T + E RED+
Sbjct: 2671 RLAQGHTTVDELARREDV 2688
Score = 122 bits (307), Expect = 1e-27
Identities = 165/741 (22%), Positives = 331/741 (44%), Gaps = 112/741 (15%)
Query: 51 ALNTRQDEAEASMEALRE---AHQEELQNAVAET---KARLLQEQGCAEEEALLQRIQAL 104
A +T + + +A +EA R+ A +EE + AE K+ +E+ + +A L+ ++ L
Sbjct: 1955 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2014
Query: 105 ESALELQKRLTEEALAESA-SCRLETKERELRVEAEHAERVLTLSREMLELKADYERRLQ 163
++ +E +RL E A ESA +L + + R++AE + ++ EL+ ++
Sbjct: 2015 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2074
Query: 164 HLTS--HEATPQGRLPQESPETKSEPG-QGPEMQEVLLEVQRLR--VENQQLSKDYARKA 218
L EA R +E+ E + + + + + + E +RL+ E Q ++ A+ A
Sbjct: 2075 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2134
Query: 219 EELQATYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEH 278
E + E E EA R+A Q+ AL Q Q ++++ K+ + E L+ Q ++E +L
Sbjct: 2135 AE-KLRKEAEQEAARRA--QAEQAALRQKQAADAEMEKHKKFAEQTLR-QKAQVEQELTT 2190
Query: 279 RGRKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECR 338
++ + L E +Q L + EA ++ S+++ E+L + +M
Sbjct: 2191 LRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE-------EELFSVRVQM------ 2237
Query: 339 GTQQTDAMKTELVSENK--VLREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEAS 396
++ +K + +EN+ +LR++++ T++
Sbjct: 2238 --EELSKLKARIEAENRALILRDKDN----------------------------TQRFLQ 2267
Query: 397 AETEYMKQQYEEDLR-KIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERK 455
E E MKQ EE R + Q + L + EDL ++ + K ++ ++A ++
Sbjct: 2268 EEAEKMKQVAEEAARLSVAAQEAARLRQLAE------EDLAQQRALAEKMLKEKMQAVQE 2321
Query: 456 KLQREVEAQLEEVRKK-SEKEIKQLEEEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGA 514
+ + EA+L + +K+ ++++ ++L+E+K + +L R E +Q +
Sbjct: 2322 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL----- 2376
Query: 515 EESPQELGRQHCSILETQDPCLKLDETSPR----GEEYQDKLAAEEGTSSDEEE--RTKV 568
E E R + E + +E + R EE +KL E + ++ +T
Sbjct: 2377 -EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2435
Query: 569 LLKEGSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQ-----------QALE 617
+ ++ SD L+E ++++R +E Q + LQ + +MQ QAL+
Sbjct: 2436 IQRQQSDHD---AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2492
Query: 618 QCTSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLEKARHQE 677
Q + ++ L ++ + E+ KL++ Q+ A QL QR + +E+ R +
Sbjct: 2493 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV----AKAQQLREEQQRQQQQMEQERQRL 2548
Query: 678 LKATEERLKKESSHSLQIQHQTHRLELQALEEKARQE---LQEERERMQAQQALLLESLR 734
+ + EE +++ H + + + ELQ LE++ RQ+ L EE +R++ Q L
Sbjct: 2549 VASMEEARRRQ--HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL------ 2600
Query: 735 QELSEQQAACSGHQKDLEALQ 755
L EQ A H +++ A Q
Sbjct: 2601 --LEEQHRAALAHSEEVTASQ 2619
Score = 108 bits (269), Expect = 3e-23
Identities = 212/1014 (20%), Positives = 408/1014 (40%), Gaps = 182/1014 (17%)
Query: 63 MEALREAHQEE--LQNAVAETKARLLQEQGCAEEEALLQRIQA-LESALELQKRLTEEAL 119
+++L + QEE Q ++E K LQ + C R+ E A E +R+ E+
Sbjct: 969 LQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQK 1028
Query: 120 AESASCRLETKERELRVEAE---------------HAERVLTLSR--EMLELKADYERRL 162
A++ L L EAE +E LTL + ++ L A Y +L
Sbjct: 1029 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1088
Query: 163 QHLTSHEATPQG-----RLPQES-PETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYAR 216
+ ++ QG R +E E ++ P PE++ +++LR + + +
Sbjct: 1089 KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1148
Query: 217 KAEELQATYE---------RENEAIRQAMQQSVSQALWQWQE-------KESDL------ 254
+EL+ E E + + ++ V+Q L +WQ ++ +L
Sbjct: 1149 LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ 1208
Query: 255 -------------------RKNFQVQ------ESALQAQVRKLEG---DLEHRGRKISDL 286
R+ Q+Q A++ Q+R+ + ++E G K+ +
Sbjct: 1209 LRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEEC 1268
Query: 287 KKYAQKLKERIQDLDVQLKEARQENSELKGTAKK----LGEKLAVAKD------------ 330
+++A++ I+D ++QL + + + AKK G + + +
Sbjct: 1269 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1328
Query: 331 -------------RMMLQECRGTQQTDAMKTELVSENKVLREENDLEAGNLHPQQDQSCL 377
R M +E R +Q A + E ++E + E+ + H Q
Sbjct: 1329 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKAQAE 1387
Query: 378 KECPCM--KGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEE------KKHLKDQLV 429
+E + + ++ ++EA+ + + K+ +E+L++++ +E E + ++
Sbjct: 1388 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1447
Query: 430 KRLEDLVKKHTVEIKSV---RSSVEAERKKLQ---REVEAQLEEVRKKSEKEIKQLEEE- 482
R+E+ ++ +++++ R E E + L+ E EAQ + ++++E+ +Q+++E
Sbjct: 1448 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1507
Query: 483 --KAALNVKLQNSL---LEVLR--------LEEFIQQNKTRPTGAEESPQELGRQHCSIL 529
K V+L + + E R LEE Q + ++ E RQ L
Sbjct: 1508 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1567
Query: 530 ETQDPCLKLDETSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLGSLLKEKTS 589
ET + + S R + +K A E S EE L+E ++ + + +
Sbjct: 1568 ETAQRSAEAELQSKRA-SFAEKTAQLE-RSLQEEHVAVAQLREEAERRAQQQAEAERARE 1625
Query: 590 KIQRLEEDWQ-----SQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQRE 644
+ +R E WQ + + +LQA+ Q++L Q +A KQ + ERE +R
Sbjct: 1626 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQA--------EAEKQKEEAEREARRRG 1677
Query: 645 LQETTQQNHAMKAQLEASHQRALRMLEKARHQELKATEE--RLKKESSHSLQIQHQTHRL 702
E A+ E QR ++ E Q L A +E RL+ E+ Q Q Q
Sbjct: 1678 KAEEQAVRQRELAEQELEKQR--QLAEGTAQQRLAAEQELIRLRAETEQGEQ-QRQLLEE 1734
Query: 703 ELQALEEKA------RQELQEERERMQAQQALLLESLRQELSEQQAACSGHQKDLEALQA 756
EL L+ +A RQEL+ E +++A+ +LL S + E ++ ++ LEA
Sbjct: 1735 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1794
Query: 757 ELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGAAGQ---GSGEGCGLWEENAQ 813
R L + A + + E Q + GE L +
Sbjct: 1795 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL---KTE 1851
Query: 814 LQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRAREVETLRQEHRK-------EMQ 866
+ A++ AE E+ ++ A+ QRR LEE Q AQ ++E + RK +
Sbjct: 1852 AEIALKEKEAENERLRRLAEDEAFQRRRLEE-QAAQHKADIEERLAQLRKASDSELERQK 1910
Query: 867 AMVADFSSAQAQLQARLAALEAELKDSGEKPGKGASRPEDLQL-IGRLQTRLKE 919
+V D + Q++ + AL+A + K A+ +L+L +GR+++ ++
Sbjct: 1911 GLVEDTLRQRRQVEEEILALKASFE-------KAAAGKAELELELGRIRSNAED 1957
Score = 66.6 bits (161), Expect = 1e-10
Identities = 87/381 (22%), Positives = 166/381 (43%), Gaps = 25/381 (6%)
Query: 56 QDEAEASMEALREAHQEEL---QNAVAETKARLLQEQGCAEEEALLQRIQALESALELQK 112
+++ +A EA R + EL Q +A+ +AR LQE + L + Q + LE ++
Sbjct: 2313 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2372
Query: 113 RLTEEALAESASCRLETKERELRVEAEHAERVLTLSREMLELKADYERRLQHLTSHEATP 172
+ E AE+ RL+ + E+ AE R+ E + R + T + T
Sbjct: 2373 QRQLEMSAEAE--RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2430
Query: 173 QGRLPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYARKAEELQATYERENEAI 232
L + ++ + ++E + E++R + + QQ +K K+EE+Q + +
Sbjct: 2431 VQTLEIQRQQSDHD---AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2487
Query: 233 RQAMQQSVSQALWQWQEKESDL-RKNFQVQESALQAQVRKLEGDLEHRGRKISDLKKYAQ 291
QA+QQS EK+S L R+ F QE A Q+ + ++ + + ++ Q
Sbjct: 2488 TQALQQSF------LSEKDSLLQRERFIEQEKAKLEQL--FQDEVAKAQQLREEQQRQQQ 2539
Query: 292 KLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECRGTQQTDAMKTELV 351
++++ Q L ++EAR+ E + ++ E+L + + Q+ R ++ A + + +
Sbjct: 2540 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL-----QQLEQQRRQQEELLAEENQRL 2594
Query: 352 SENKVLREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEASAETEYMKQQYEEDLR 411
E L EE A + S + + G D A AE E+ ++ R
Sbjct: 2595 REQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEH---SFDGLRR 2651
Query: 412 KIKHQTEEEKKHLKDQLVKRL 432
K+ Q +E L + ++RL
Sbjct: 2652 KVSAQRLQEAGILSAEELQRL 2672
Score = 55.5 bits (132), Expect = 3e-07
Identities = 114/568 (20%), Positives = 238/568 (41%), Gaps = 38/568 (6%)
Query: 385 GGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDL-VKKHTVEI 443
GG + + A E Y++ L+ ++ +EE + + + L+D+ ++ E
Sbjct: 944 GGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRC--QRCISELKDIRLQLEACET 1001
Query: 444 KSVRSSVEAERKKLQREVEAQLEEVRKKSEKEIKQLEEEKAALNVKLQN--SLLEVLRLE 501
++V K+ RE ++ E ++K++ E++ L + A L+ + + +L E
Sbjct: 1002 RTVHRLRLPLDKEPARECAQRIAE-QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAA 1060
Query: 502 EFIQQNKTRPTGAEESPQELGRQHCSILETQDPCLKLDETSP---RGEEYQDKLAAEEGT 558
++ G E + L + L+T ++ + + R E Q K A
Sbjct: 1061 PTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1120
Query: 559 SSDEEERTKVLLKE---GSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQQA 615
+ E E TK LK+ ++ Q P L+++ Q + E Q + + +V + ++
Sbjct: 1121 TLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1180
Query: 616 LEQCTSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLEKARH 675
+ Q ++ L A + E E+L R+L+ + + A L+ + +R ++
Sbjct: 1181 VAQLLERWQAVL-AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ-EQIQAMPL 1238
Query: 676 QELKATEERLKKESSHSLQIQHQTHRLE-LQALEEKARQELQEERERMQAQQALL--LES 732
+ +A E+L++E + +I+ ++E Q ++ +++ ++ +A L + S
Sbjct: 1239 ADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVAS 1298
Query: 733 LRQELSEQQAACSGHQK--DLEALQAELRALGRQQA---SSQCPGDSKDHIIATEERGGP 787
++ Q + S Q+ DL +EL L Q S ++ +A ++R
Sbjct: 1299 PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE 1358
Query: 788 GQAGSPPGAAGQGSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQ 847
+ + AA + + L E +AQ + R E++Q QE R++ + Q+
Sbjct: 1359 RERLAEVEAALEKQRQ---LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1415
Query: 848 AQRAREVETLRQEHRKEMQAM-----VADFSSAQAQLQARLAALEAELKDSGEKPGKGAS 902
E++ LRQ E+QA A+ S + + + R+ L+ E + +G
Sbjct: 1416 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG-- 1473
Query: 903 RPEDLQLIGRLQTRLKEREDIIKQLTEE 930
+LQ L+ R +E E +Q EE
Sbjct: 1474 ---ELQ---ALRARAEEAEAQKRQAQEE 1495
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 142 bits (358), Expect = 2e-33
Identities = 228/975 (23%), Positives = 427/975 (43%), Gaps = 117/975 (12%)
Query: 55 RQDEAEASMEALREAHQEEL----QNAVAETKARLLQEQGC------AEEEALLQRIQ-- 102
R++EA + + + QEEL Q++ AE +A+ Q + EEE + R+Q
Sbjct: 1407 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1466
Query: 103 -------ALESALELQKRLTEEALAESASCRLETKERELRVEAEHAERVLTLSREMLELK 155
E L+ + EEA A+ + E + +V+ E + +K
Sbjct: 1467 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1526
Query: 156 ADYERRLQHLTSHEATPQGRLPQESPETK---SEPGQGPEMQEVLLEVQR-LRVENQQLS 211
A+ E + + +A + RL E E + +E + ++Q L QR E Q
Sbjct: 1527 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1586
Query: 212 KDYARKAEELQATYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRK 271
+A K +L+ + + E+ A+ Q +++ +A Q Q A +A+ +
Sbjct: 1587 ASFAEKTAQLERSLQEEHVAVAQLREEAERRA---------------QQQAEAERAR-EE 1630
Query: 272 LEGDLEHRGRKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLG--EKLAVAK 329
E +LE K ++ + + +E Q + EA ++ E + A++ G E+ AV +
Sbjct: 1631 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1690
Query: 330 DRMMLQECRGTQQ--TDAMKTELVSENKVLREENDLEAGNLHPQQDQSCLKECPCMKGGT 387
+ QE +Q + L +E +++R + E G QQ Q +E ++
Sbjct: 1691 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE---QQRQLLEEELARLQREA 1747
Query: 388 DMQTKKEASAETEYMKQQYE-EDLRKIKHQTEEEKKHLKDQLVKRLE-DLVKKHTVEIKS 445
T+K E E K + E E L K + EEE + ++ +RLE + + + ++
Sbjct: 1748 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1807
Query: 446 VRSSVEAERKKLQREVEAQLEEVRKKSEKEIKQLEEEKAALNVKLQNSLLEVLRLEEFIQ 505
R AE K QR++ A+ + R+++E E + L E+ AA+ + + L+E
Sbjct: 1808 ARLRALAEEAKRQRQL-AEEDAARQRAEAE-RVLAEKLAAIGEATRLKTEAEIALKEKEA 1865
Query: 506 QNKTRPTGAEESPQELGRQHCSILETQDPCLKLDETSPRGEEYQDKLAAEEGTSSDEEER 565
+N+ AE+ + R LE Q K D +++LA S E ER
Sbjct: 1866 ENERLRRLAEDEAFQRRR-----LEEQAAQHKAD--------IEERLAQLRKASDSELER 1912
Query: 566 TKVLLKEGSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQ-QALEQCTSNYR 624
K L+++ + ++E+ ++ E + KA+L+ ++ +++ A + S +
Sbjct: 1913 QKGLVEDTLRQR----RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ 1968
Query: 625 EDLQALKQLS-DLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLE--KARHQELKAT 681
+L+A +Q E E+ +RE +E Q++ A + + + AL +E KA+ +E +
Sbjct: 1969 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRL 2028
Query: 682 EERLKKESSHSLQIQHQTHRLELQALEEKAR----QELQEERERMQAQQALLLESLRQEL 737
ER ++ES+ LQ+ + + LQA EEKA Q+ ++E ++ Q+ +L+ LR E
Sbjct: 2029 RERAEQESARQLQLAQEAAQKRLQA-EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2087
Query: 738 SEQQAACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGAA 797
+ A EA +A ++A R+ A S+ + + + + E + A
Sbjct: 2088 EAARRAAE------EAEEARVQA-EREAAQSRRQVEEAERLKQSAEEQAQAR------AQ 2134
Query: 798 GQGSGEGCGLWEENAQLQDAVRRLRAE---VEQHQQEAQKLRDQRRFLEET--QQAQRAR 852
Q + E E Q+A RR +AE + Q Q ++ ++F E+T Q+AQ +
Sbjct: 2135 AQAAAEKLRKEAE----QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2190
Query: 853 EVETLR-----QEHRK-----EMQAMVADFSSA---QAQLQARLAALEAELKDSGEKPGK 899
E+ TLR +H+K E+Q + A+ + A ++Q++ L ++ ++++ + K
Sbjct: 2191 ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL--K 2248
Query: 900 GASRPEDLQLIGR----LQTRLKEREDIIKQLTEERRFHYAAFPSAMSHRNRSFSFNPHP 955
E+ LI R Q L+E + +KQ+ EE A A R +
Sbjct: 2249 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2308
Query: 956 GYLTPSMKKKKVEDV 970
L M K+K++ V
Sbjct: 2309 RALAEKMLKEKMQAV 2323
Score = 138 bits (348), Expect = 2e-32
Identities = 222/971 (22%), Positives = 413/971 (42%), Gaps = 141/971 (14%)
Query: 47 KVIYALNTRQDEAEASMEALREAHQEELQNAVAETKARLLQEQGCAEEEALLQRIQALES 106
+ + AL + +AE + LR+A E + + + L Q AE E +R E
Sbjct: 1537 RALQALEELRLQAEEAERRLRQAEVERAR----QVQVALETAQRSAEAELQSKRASFAEK 1592
Query: 107 ALELQKRLTEEALAESASCRLETKER-ELRVEAEHAERVLTLSREMLELKADYERRLQHL 165
+L++ L EE +A A R E + R + + EAE A E +LKA+ RL+ L
Sbjct: 1593 TAQLERSLQEEHVA-VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR-L 1650
Query: 166 TSHEATPQGRLPQESPETKSEPGQGPEMQEVLLEVQRLR---VENQQLSKDYARKAEELQ 222
+ E Q L Q E + E + + E Q +R + Q+L K Q
Sbjct: 1651 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1710
Query: 223 ATYERENEAIR--------QAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEG 274
E E IR + +Q + + L + Q + + + Q E+ L ++E
Sbjct: 1711 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1770
Query: 275 DLEHRGRKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAK----- 329
L + R + + ++K K+R++ + +E +E + L+ A++ + +A+
Sbjct: 1771 LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR 1830
Query: 330 -----DRMMLQECRGTQQTDAMKTEL-------VSENKVLREENDLEAGNLHPQQDQSCL 377
+R++ ++ + +KTE +EN+ LR + EA ++Q+
Sbjct: 1831 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ 1890
Query: 378 KECPCMKGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVK------- 430
+ + Q +K + +E E K E+ LR+ + Q EEE LK K
Sbjct: 1891 HKADIEE--RLAQLRKASDSELERQKGLVEDTLRQ-RRQVEEEILALKASFEKAAAGKAE 1947
Query: 431 ----------RLEDLVK-KHTVEIKSVRS-SVEAERKKLQREVEAQLEEVRKKSEKEIKQ 478
ED ++ K E+++ R + AE ++ +RE E E V+K E +
Sbjct: 1948 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE---ERVQKSLAAEEEA 2004
Query: 479 LEEEKAALN--VKLQNSLLEVLRLEEFIQQNKTRPTG-AEESPQE--LGRQHCSILETQD 533
+ KAAL +L+ + E RL E +Q R A+E+ Q+ + Q
Sbjct: 2005 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2064
Query: 534 PCLKLDETSPRGEEYQDKLAAEEGT---SSDEEERTKVLLKEGSDPQPPLGSLLKEKTSK 590
+L +T + + D+L E +++E E +V ++ + E+ +
Sbjct: 2065 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV----QAEREAAQSRRQVEEAER 2120
Query: 591 IQRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQAL---KQLSDLEREKLQRELQE 647
+++ E+ +A+ QA ++++ EQ + + QA KQ +D E EK ++ ++
Sbjct: 2121 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2180
Query: 648 TTQQNHAMKAQLEASHQRALRMLEKARHQELKATEE--RLKKESSHSLQIQHQTH----- 700
T +Q KAQ+E LE+ HQ+ EE RLK E++ + + + Q
Sbjct: 2181 TLRQ----KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2236
Query: 701 -RLELQALEE-KARQE-----------------LQEERERMQ--AQQALLLESLRQELSE 739
R++++ L + KAR E LQEE E+M+ A++A L QE +
Sbjct: 2237 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2296
Query: 740 QQAACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGAAGQ 799
+ ++DL A+ RAL + K+ + A +E A +
Sbjct: 2297 LRQLA---EEDL----AQQRALAEKML--------KEKMQAVQE-------------ATR 2328
Query: 800 GSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRAREVETLRQ 859
E L ++ Q+ RRL+ E +Q AQ+L ++ + + T +A+R R++E +
Sbjct: 2329 LKAEAELLQQQKELAQEQARRLQ---EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2385
Query: 860 EHRKEMQAMVADFSSAQAQLQARLAALEAELKDSGEKPGK-GASRPEDLQLIGRLQTRLK 918
R +++ VA+ S AQA+ + + ++ GEK + + E + L+ L+ + +
Sbjct: 2386 AERLKLR--VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ 2443
Query: 919 EREDIIKQLTE 929
+ + ++L E
Sbjct: 2444 QSDHDAERLRE 2454
Score = 128 bits (322), Expect = 2e-29
Identities = 206/918 (22%), Positives = 397/918 (43%), Gaps = 132/918 (14%)
Query: 58 EAEASMEALREAHQEELQNAVAETKA---RLLQEQGCAE----EEALLQRIQALESALEL 110
EAE +++ +EA E L+ +AE +A R L+EQ EE L Q +A +S LE
Sbjct: 1855 EAEIALKE-KEAENERLRR-LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1912
Query: 111 QKRLTEEAL-------------------AESASCRLETKERELRVEAEHAERVLTLSREM 151
QK L E+ L A + LE + +R AE R S+E
Sbjct: 1913 QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR----SKEQ 1968
Query: 152 LELKADYERRLQHLTSHEATPQGRLPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLS 211
EL+A +R+L Q+S + E + + + L EV+RL+ + ++
Sbjct: 1969 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR--QRKAALEEVERLKAKVEEAR 2026
Query: 212 KDYARKAEELQATYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRK 271
+ R +E + EA ++ +Q + Q+KE +L++ Q ++S L +
Sbjct: 2027 RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD----Q 2082
Query: 272 LEGDLEHRGRKISDLK-------KYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEK 324
L G+ E R + + + A + + ++++ + +LK++ +E ++ + A+ EK
Sbjct: 2083 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-RLKQSAEEQAQARAQAQAAAEK 2141
Query: 325 LAVAKDRMMLQECRGTQQTDAMKTELVSENKVLREENDLEAG-NLHPQQDQSCLKECPCM 383
L + +Q A + + +E LR++ +A H + + L++ +
Sbjct: 2142 LR-----------KEAEQEAARRAQ--AEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2188
Query: 384 KGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEI 443
+ ++ T + ET++ K +E+L+++K + E + + Q+ + L V+ E+
Sbjct: 2189 E--QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ-RSQVEEELFS-VRVQMEEL 2244
Query: 444 KSVRSSVEAERKKLQREVEAQLEEVRKKSEKEIKQLEEEKAALNVKLQNSL-LEVLRLEE 502
+++ +EAE + L + + ++ +++KQ+ EE A L+V Q + L L E+
Sbjct: 2245 SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2304
Query: 503 FIQQNKTRPTGAEESPQELGRQHCSILETQDPCLKLDETSPRGEEYQDKLAAEEGT--SS 560
QQ +E Q + Q + L+ + L + Q +LA E+
Sbjct: 2305 LAQQRALAEKMLKEKMQAV--QEATRLKAEAELL----------QQQKELAQEQARRLQE 2352
Query: 561 DEEERTKVLLKEGSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQ-AQVSQMQQALEQC 619
D+E+ + L +E Q L + + ++LE ++++ KL+ A++S+ Q E
Sbjct: 2353 DKEQMAQQLAEETQGFQRTL------EAERQRQLEMSAEAERLKLRVAEMSRAQARAE-- 2404
Query: 620 TSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLEKARHQ--E 677
ED Q ++ ++ EKL R + TQ+ + LE Q++ E+ R E
Sbjct: 2405 -----EDAQRFRKQAEEIGEKLHRT-ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2458
Query: 678 LKATEERLKKESSHSLQIQHQTHRLELQALE-EKARQELQEERERMQAQQALLLESLRQE 736
L+ +E+L++E+ LQ++ + E+Q ++ E+ QE Q ++ +++ LL+ R
Sbjct: 2459 LEREKEKLQQEAK-LLQLKSE----EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF- 2512
Query: 737 LSEQQAACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGA 796
+ +++A +D A +LR QQ Q + ++A+ E Q + G
Sbjct: 2513 IEQEKAKLEQLFQDEVAKAQQLRE--EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2570
Query: 797 AGQGSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRAREVET 856
+ +LQ ++ R + E +E Q+LR+Q + LEE +A A E
Sbjct: 2571 R-----------RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2619
Query: 857 LRQEHRKEMQAMVADFSSAQAQLQARLAALEAELKDSGEKPGKGASR--------PEDLQ 908
+ A + + L A E E G + A R E+LQ
Sbjct: 2620 TASQ-----VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQ 2674
Query: 909 LIGRLQTRLKE---REDI 923
+ + T + E RED+
Sbjct: 2675 RLAQGHTTVDELARREDV 2692
Score = 122 bits (307), Expect = 1e-27
Identities = 165/741 (22%), Positives = 331/741 (44%), Gaps = 112/741 (15%)
Query: 51 ALNTRQDEAEASMEALRE---AHQEELQNAVAET---KARLLQEQGCAEEEALLQRIQAL 104
A +T + + +A +EA R+ A +EE + AE K+ +E+ + +A L+ ++ L
Sbjct: 1959 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2018
Query: 105 ESALELQKRLTEEALAESA-SCRLETKERELRVEAEHAERVLTLSREMLELKADYERRLQ 163
++ +E +RL E A ESA +L + + R++AE + ++ EL+ ++
Sbjct: 2019 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2078
Query: 164 HLTS--HEATPQGRLPQESPETKSEPG-QGPEMQEVLLEVQRLR--VENQQLSKDYARKA 218
L EA R +E+ E + + + + + + E +RL+ E Q ++ A+ A
Sbjct: 2079 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2138
Query: 219 EELQATYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEH 278
E + E E EA R+A Q+ AL Q Q ++++ K+ + E L+ Q ++E +L
Sbjct: 2139 AE-KLRKEAEQEAARRA--QAEQAALRQKQAADAEMEKHKKFAEQTLR-QKAQVEQELTT 2194
Query: 279 RGRKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECR 338
++ + L E +Q L + EA ++ S+++ E+L + +M
Sbjct: 2195 LRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE-------EELFSVRVQM------ 2241
Query: 339 GTQQTDAMKTELVSENK--VLREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEAS 396
++ +K + +EN+ +LR++++ T++
Sbjct: 2242 --EELSKLKARIEAENRALILRDKDN----------------------------TQRFLQ 2271
Query: 397 AETEYMKQQYEEDLR-KIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERK 455
E E MKQ EE R + Q + L + EDL ++ + K ++ ++A ++
Sbjct: 2272 EEAEKMKQVAEEAARLSVAAQEAARLRQLAE------EDLAQQRALAEKMLKEKMQAVQE 2325
Query: 456 KLQREVEAQLEEVRKK-SEKEIKQLEEEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGA 514
+ + EA+L + +K+ ++++ ++L+E+K + +L R E +Q +
Sbjct: 2326 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL----- 2380
Query: 515 EESPQELGRQHCSILETQDPCLKLDETSPR----GEEYQDKLAAEEGTSSDEEE--RTKV 568
E E R + E + +E + R EE +KL E + ++ +T
Sbjct: 2381 -EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2439
Query: 569 LLKEGSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQ-----------QALE 617
+ ++ SD L+E ++++R +E Q + LQ + +MQ QAL+
Sbjct: 2440 IQRQQSDHD---AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2496
Query: 618 QCTSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLEKARHQE 677
Q + ++ L ++ + E+ KL++ Q+ A QL QR + +E+ R +
Sbjct: 2497 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV----AKAQQLREEQQRQQQQMEQERQRL 2552
Query: 678 LKATEERLKKESSHSLQIQHQTHRLELQALEEKARQE---LQEERERMQAQQALLLESLR 734
+ + EE +++ H + + + ELQ LE++ RQ+ L EE +R++ Q L
Sbjct: 2553 VASMEEARRRQ--HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL------ 2604
Query: 735 QELSEQQAACSGHQKDLEALQ 755
L EQ A H +++ A Q
Sbjct: 2605 --LEEQHRAALAHSEEVTASQ 2623
Score = 108 bits (269), Expect = 3e-23
Identities = 212/1014 (20%), Positives = 408/1014 (40%), Gaps = 182/1014 (17%)
Query: 63 MEALREAHQEE--LQNAVAETKARLLQEQGCAEEEALLQRIQA-LESALELQKRLTEEAL 119
+++L + QEE Q ++E K LQ + C R+ E A E +R+ E+
Sbjct: 973 LQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQK 1032
Query: 120 AESASCRLETKERELRVEAE---------------HAERVLTLSR--EMLELKADYERRL 162
A++ L L EAE +E LTL + ++ L A Y +L
Sbjct: 1033 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1092
Query: 163 QHLTSHEATPQG-----RLPQES-PETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYAR 216
+ ++ QG R +E E ++ P PE++ +++LR + + +
Sbjct: 1093 KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1152
Query: 217 KAEELQATYE---------RENEAIRQAMQQSVSQALWQWQE-------KESDL------ 254
+EL+ E E + + ++ V+Q L +WQ ++ +L
Sbjct: 1153 LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ 1212
Query: 255 -------------------RKNFQVQ------ESALQAQVRKLEG---DLEHRGRKISDL 286
R+ Q+Q A++ Q+R+ + ++E G K+ +
Sbjct: 1213 LRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEEC 1272
Query: 287 KKYAQKLKERIQDLDVQLKEARQENSELKGTAKK----LGEKLAVAKD------------ 330
+++A++ I+D ++QL + + + AKK G + + +
Sbjct: 1273 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1332
Query: 331 -------------RMMLQECRGTQQTDAMKTELVSENKVLREENDLEAGNLHPQQDQSCL 377
R M +E R +Q A + E ++E + E+ + H Q
Sbjct: 1333 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKAQAE 1391
Query: 378 KECPCM--KGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEE------KKHLKDQLV 429
+E + + ++ ++EA+ + + K+ +E+L++++ +E E + ++
Sbjct: 1392 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1451
Query: 430 KRLEDLVKKHTVEIKSV---RSSVEAERKKLQ---REVEAQLEEVRKKSEKEIKQLEEE- 482
R+E+ ++ +++++ R E E + L+ E EAQ + ++++E+ +Q+++E
Sbjct: 1452 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1511
Query: 483 --KAALNVKLQNSL---LEVLR--------LEEFIQQNKTRPTGAEESPQELGRQHCSIL 529
K V+L + + E R LEE Q + ++ E RQ L
Sbjct: 1512 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1571
Query: 530 ETQDPCLKLDETSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLGSLLKEKTS 589
ET + + S R + +K A E S EE L+E ++ + + +
Sbjct: 1572 ETAQRSAEAELQSKRA-SFAEKTAQLE-RSLQEEHVAVAQLREEAERRAQQQAEAERARE 1629
Query: 590 KIQRLEEDWQ-----SQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQRE 644
+ +R E WQ + + +LQA+ Q++L Q +A KQ + ERE +R
Sbjct: 1630 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQA--------EAEKQKEEAEREARRRG 1681
Query: 645 LQETTQQNHAMKAQLEASHQRALRMLEKARHQELKATEE--RLKKESSHSLQIQHQTHRL 702
E A+ E QR ++ E Q L A +E RL+ E+ Q Q Q
Sbjct: 1682 KAEEQAVRQRELAEQELEKQR--QLAEGTAQQRLAAEQELIRLRAETEQGEQ-QRQLLEE 1738
Query: 703 ELQALEEKA------RQELQEERERMQAQQALLLESLRQELSEQQAACSGHQKDLEALQA 756
EL L+ +A RQEL+ E +++A+ +LL S + E ++ ++ LEA
Sbjct: 1739 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1798
Query: 757 ELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGAAGQ---GSGEGCGLWEENAQ 813
R L + A + + E Q + GE L +
Sbjct: 1799 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL---KTE 1855
Query: 814 LQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRAREVETLRQEHRK-------EMQ 866
+ A++ AE E+ ++ A+ QRR LEE Q AQ ++E + RK +
Sbjct: 1856 AEIALKEKEAENERLRRLAEDEAFQRRRLEE-QAAQHKADIEERLAQLRKASDSELERQK 1914
Query: 867 AMVADFSSAQAQLQARLAALEAELKDSGEKPGKGASRPEDLQL-IGRLQTRLKE 919
+V D + Q++ + AL+A + K A+ +L+L +GR+++ ++
Sbjct: 1915 GLVEDTLRQRRQVEEEILALKASFE-------KAAAGKAELELELGRIRSNAED 1961
Score = 66.6 bits (161), Expect = 1e-10
Identities = 87/381 (22%), Positives = 166/381 (43%), Gaps = 25/381 (6%)
Query: 56 QDEAEASMEALREAHQEEL---QNAVAETKARLLQEQGCAEEEALLQRIQALESALELQK 112
+++ +A EA R + EL Q +A+ +AR LQE + L + Q + LE ++
Sbjct: 2317 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2376
Query: 113 RLTEEALAESASCRLETKERELRVEAEHAERVLTLSREMLELKADYERRLQHLTSHEATP 172
+ E AE+ RL+ + E+ AE R+ E + R + T + T
Sbjct: 2377 QRQLEMSAEAE--RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2434
Query: 173 QGRLPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYARKAEELQATYERENEAI 232
L + ++ + ++E + E++R + + QQ +K K+EE+Q + +
Sbjct: 2435 VQTLEIQRQQSDHD---AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2491
Query: 233 RQAMQQSVSQALWQWQEKESDL-RKNFQVQESALQAQVRKLEGDLEHRGRKISDLKKYAQ 291
QA+QQS EK+S L R+ F QE A Q+ + ++ + + ++ Q
Sbjct: 2492 TQALQQSF------LSEKDSLLQRERFIEQEKAKLEQL--FQDEVAKAQQLREEQQRQQQ 2543
Query: 292 KLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECRGTQQTDAMKTELV 351
++++ Q L ++EAR+ E + ++ E+L + + Q+ R ++ A + + +
Sbjct: 2544 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL-----QQLEQQRRQQEELLAEENQRL 2598
Query: 352 SENKVLREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEASAETEYMKQQYEEDLR 411
E L EE A + S + + G D A AE E+ ++ R
Sbjct: 2599 REQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEH---SFDGLRR 2655
Query: 412 KIKHQTEEEKKHLKDQLVKRL 432
K+ Q +E L + ++RL
Sbjct: 2656 KVSAQRLQEAGILSAEELQRL 2676
Score = 55.5 bits (132), Expect = 3e-07
Identities = 114/568 (20%), Positives = 238/568 (41%), Gaps = 38/568 (6%)
Query: 385 GGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDL-VKKHTVEI 443
GG + + A E Y++ L+ ++ +EE + + + L+D+ ++ E
Sbjct: 948 GGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRC--QRCISELKDIRLQLEACET 1005
Query: 444 KSVRSSVEAERKKLQREVEAQLEEVRKKSEKEIKQLEEEKAALNVKLQN--SLLEVLRLE 501
++V K+ RE ++ E ++K++ E++ L + A L+ + + +L E
Sbjct: 1006 RTVHRLRLPLDKEPARECAQRIAE-QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAA 1064
Query: 502 EFIQQNKTRPTGAEESPQELGRQHCSILETQDPCLKLDETSP---RGEEYQDKLAAEEGT 558
++ G E + L + L+T ++ + + R E Q K A
Sbjct: 1065 PTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1124
Query: 559 SSDEEERTKVLLKE---GSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQQA 615
+ E E TK LK+ ++ Q P L+++ Q + E Q + + +V + ++
Sbjct: 1125 TLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1184
Query: 616 LEQCTSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLEKARH 675
+ Q ++ L A + E E+L R+L+ + + A L+ + +R ++
Sbjct: 1185 VAQLLERWQAVL-AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ-EQIQAMPL 1242
Query: 676 QELKATEERLKKESSHSLQIQHQTHRLE-LQALEEKARQELQEERERMQAQQALL--LES 732
+ +A E+L++E + +I+ ++E Q ++ +++ ++ +A L + S
Sbjct: 1243 ADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVAS 1302
Query: 733 LRQELSEQQAACSGHQK--DLEALQAELRALGRQQA---SSQCPGDSKDHIIATEERGGP 787
++ Q + S Q+ DL +EL L Q S ++ +A ++R
Sbjct: 1303 PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE 1362
Query: 788 GQAGSPPGAAGQGSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQ 847
+ + AA + + L E +AQ + R E++Q QE R++ + Q+
Sbjct: 1363 RERLAEVEAALEKQRQ---LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1419
Query: 848 AQRAREVETLRQEHRKEMQAM-----VADFSSAQAQLQARLAALEAELKDSGEKPGKGAS 902
E++ LRQ E+QA A+ S + + + R+ L+ E + +G
Sbjct: 1420 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG-- 1477
Query: 903 RPEDLQLIGRLQTRLKEREDIIKQLTEE 930
+LQ L+ R +E E +Q EE
Sbjct: 1478 ---ELQ---ALRARAEEAEAQKRQAQEE 1499
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 142 bits (358), Expect = 2e-33
Identities = 228/975 (23%), Positives = 427/975 (43%), Gaps = 117/975 (12%)
Query: 55 RQDEAEASMEALREAHQEEL----QNAVAETKARLLQEQGC------AEEEALLQRIQ-- 102
R++EA + + + QEEL Q++ AE +A+ Q + EEE + R+Q
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1462
Query: 103 -------ALESALELQKRLTEEALAESASCRLETKERELRVEAEHAERVLTLSREMLELK 155
E L+ + EEA A+ + E + +V+ E + +K
Sbjct: 1463 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1522
Query: 156 ADYERRLQHLTSHEATPQGRLPQESPETK---SEPGQGPEMQEVLLEVQR-LRVENQQLS 211
A+ E + + +A + RL E E + +E + ++Q L QR E Q
Sbjct: 1523 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1582
Query: 212 KDYARKAEELQATYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRK 271
+A K +L+ + + E+ A+ Q +++ +A Q Q A +A+ +
Sbjct: 1583 ASFAEKTAQLERSLQEEHVAVAQLREEAERRA---------------QQQAEAERAR-EE 1626
Query: 272 LEGDLEHRGRKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLG--EKLAVAK 329
E +LE K ++ + + +E Q + EA ++ E + A++ G E+ AV +
Sbjct: 1627 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1686
Query: 330 DRMMLQECRGTQQ--TDAMKTELVSENKVLREENDLEAGNLHPQQDQSCLKECPCMKGGT 387
+ QE +Q + L +E +++R + E G QQ Q +E ++
Sbjct: 1687 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE---QQRQLLEEELARLQREA 1743
Query: 388 DMQTKKEASAETEYMKQQYE-EDLRKIKHQTEEEKKHLKDQLVKRLE-DLVKKHTVEIKS 445
T+K E E K + E E L K + EEE + ++ +RLE + + + ++
Sbjct: 1744 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1803
Query: 446 VRSSVEAERKKLQREVEAQLEEVRKKSEKEIKQLEEEKAALNVKLQNSLLEVLRLEEFIQ 505
R AE K QR++ A+ + R+++E E + L E+ AA+ + + L+E
Sbjct: 1804 ARLRALAEEAKRQRQL-AEEDAARQRAEAE-RVLAEKLAAIGEATRLKTEAEIALKEKEA 1861
Query: 506 QNKTRPTGAEESPQELGRQHCSILETQDPCLKLDETSPRGEEYQDKLAAEEGTSSDEEER 565
+N+ AE+ + R LE Q K D +++LA S E ER
Sbjct: 1862 ENERLRRLAEDEAFQRRR-----LEEQAAQHKAD--------IEERLAQLRKASDSELER 1908
Query: 566 TKVLLKEGSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQ-QALEQCTSNYR 624
K L+++ + ++E+ ++ E + KA+L+ ++ +++ A + S +
Sbjct: 1909 QKGLVEDTLRQR----RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ 1964
Query: 625 EDLQALKQLS-DLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLE--KARHQELKAT 681
+L+A +Q E E+ +RE +E Q++ A + + + AL +E KA+ +E +
Sbjct: 1965 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRL 2024
Query: 682 EERLKKESSHSLQIQHQTHRLELQALEEKAR----QELQEERERMQAQQALLLESLRQEL 737
ER ++ES+ LQ+ + + LQA EEKA Q+ ++E ++ Q+ +L+ LR E
Sbjct: 2025 RERAEQESARQLQLAQEAAQKRLQA-EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2083
Query: 738 SEQQAACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGAA 797
+ A EA +A ++A R+ A S+ + + + + E + A
Sbjct: 2084 EAARRAAE------EAEEARVQA-EREAAQSRRQVEEAERLKQSAEEQAQAR------AQ 2130
Query: 798 GQGSGEGCGLWEENAQLQDAVRRLRAE---VEQHQQEAQKLRDQRRFLEET--QQAQRAR 852
Q + E E Q+A RR +AE + Q Q ++ ++F E+T Q+AQ +
Sbjct: 2131 AQAAAEKLRKEAE----QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2186
Query: 853 EVETLR-----QEHRK-----EMQAMVADFSSA---QAQLQARLAALEAELKDSGEKPGK 899
E+ TLR +H+K E+Q + A+ + A ++Q++ L ++ ++++ + K
Sbjct: 2187 ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL--K 2244
Query: 900 GASRPEDLQLIGR----LQTRLKEREDIIKQLTEERRFHYAAFPSAMSHRNRSFSFNPHP 955
E+ LI R Q L+E + +KQ+ EE A A R +
Sbjct: 2245 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2304
Query: 956 GYLTPSMKKKKVEDV 970
L M K+K++ V
Sbjct: 2305 RALAEKMLKEKMQAV 2319
Score = 138 bits (348), Expect = 2e-32
Identities = 222/971 (22%), Positives = 413/971 (42%), Gaps = 141/971 (14%)
Query: 47 KVIYALNTRQDEAEASMEALREAHQEELQNAVAETKARLLQEQGCAEEEALLQRIQALES 106
+ + AL + +AE + LR+A E + + + L Q AE E +R E
Sbjct: 1533 RALQALEELRLQAEEAERRLRQAEVERAR----QVQVALETAQRSAEAELQSKRASFAEK 1588
Query: 107 ALELQKRLTEEALAESASCRLETKER-ELRVEAEHAERVLTLSREMLELKADYERRLQHL 165
+L++ L EE +A A R E + R + + EAE A E +LKA+ RL+ L
Sbjct: 1589 TAQLERSLQEEHVA-VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR-L 1646
Query: 166 TSHEATPQGRLPQESPETKSEPGQGPEMQEVLLEVQRLR---VENQQLSKDYARKAEELQ 222
+ E Q L Q E + E + + E Q +R + Q+L K Q
Sbjct: 1647 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1706
Query: 223 ATYERENEAIR--------QAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEG 274
E E IR + +Q + + L + Q + + + Q E+ L ++E
Sbjct: 1707 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1766
Query: 275 DLEHRGRKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAK----- 329
L + R + + ++K K+R++ + +E +E + L+ A++ + +A+
Sbjct: 1767 LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR 1826
Query: 330 -----DRMMLQECRGTQQTDAMKTEL-------VSENKVLREENDLEAGNLHPQQDQSCL 377
+R++ ++ + +KTE +EN+ LR + EA ++Q+
Sbjct: 1827 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ 1886
Query: 378 KECPCMKGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVK------- 430
+ + Q +K + +E E K E+ LR+ + Q EEE LK K
Sbjct: 1887 HKADIEE--RLAQLRKASDSELERQKGLVEDTLRQ-RRQVEEEILALKASFEKAAAGKAE 1943
Query: 431 ----------RLEDLVK-KHTVEIKSVRS-SVEAERKKLQREVEAQLEEVRKKSEKEIKQ 478
ED ++ K E+++ R + AE ++ +RE E E V+K E +
Sbjct: 1944 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE---ERVQKSLAAEEEA 2000
Query: 479 LEEEKAALN--VKLQNSLLEVLRLEEFIQQNKTRPTG-AEESPQE--LGRQHCSILETQD 533
+ KAAL +L+ + E RL E +Q R A+E+ Q+ + Q
Sbjct: 2001 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2060
Query: 534 PCLKLDETSPRGEEYQDKLAAEEGT---SSDEEERTKVLLKEGSDPQPPLGSLLKEKTSK 590
+L +T + + D+L E +++E E +V ++ + E+ +
Sbjct: 2061 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV----QAEREAAQSRRQVEEAER 2116
Query: 591 IQRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQAL---KQLSDLEREKLQRELQE 647
+++ E+ +A+ QA ++++ EQ + + QA KQ +D E EK ++ ++
Sbjct: 2117 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2176
Query: 648 TTQQNHAMKAQLEASHQRALRMLEKARHQELKATEE--RLKKESSHSLQIQHQTH----- 700
T +Q KAQ+E LE+ HQ+ EE RLK E++ + + + Q
Sbjct: 2177 TLRQ----KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2232
Query: 701 -RLELQALEE-KARQE-----------------LQEERERMQ--AQQALLLESLRQELSE 739
R++++ L + KAR E LQEE E+M+ A++A L QE +
Sbjct: 2233 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2292
Query: 740 QQAACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGAAGQ 799
+ ++DL A+ RAL + K+ + A +E A +
Sbjct: 2293 LRQLA---EEDL----AQQRALAEKML--------KEKMQAVQE-------------ATR 2324
Query: 800 GSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRAREVETLRQ 859
E L ++ Q+ RRL+ E +Q AQ+L ++ + + T +A+R R++E +
Sbjct: 2325 LKAEAELLQQQKELAQEQARRLQ---EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2381
Query: 860 EHRKEMQAMVADFSSAQAQLQARLAALEAELKDSGEKPGK-GASRPEDLQLIGRLQTRLK 918
R +++ VA+ S AQA+ + + ++ GEK + + E + L+ L+ + +
Sbjct: 2382 AERLKLR--VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ 2439
Query: 919 EREDIIKQLTE 929
+ + ++L E
Sbjct: 2440 QSDHDAERLRE 2450
Score = 128 bits (322), Expect = 2e-29
Identities = 206/918 (22%), Positives = 397/918 (43%), Gaps = 132/918 (14%)
Query: 58 EAEASMEALREAHQEELQNAVAETKA---RLLQEQGCAE----EEALLQRIQALESALEL 110
EAE +++ +EA E L+ +AE +A R L+EQ EE L Q +A +S LE
Sbjct: 1851 EAEIALKE-KEAENERLRR-LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1908
Query: 111 QKRLTEEAL-------------------AESASCRLETKERELRVEAEHAERVLTLSREM 151
QK L E+ L A + LE + +R AE R S+E
Sbjct: 1909 QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR----SKEQ 1964
Query: 152 LELKADYERRLQHLTSHEATPQGRLPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLS 211
EL+A +R+L Q+S + E + + + L EV+RL+ + ++
Sbjct: 1965 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR--QRKAALEEVERLKAKVEEAR 2022
Query: 212 KDYARKAEELQATYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRK 271
+ R +E + EA ++ +Q + Q+KE +L++ Q ++S L +
Sbjct: 2023 RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD----Q 2078
Query: 272 LEGDLEHRGRKISDLK-------KYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEK 324
L G+ E R + + + A + + ++++ + +LK++ +E ++ + A+ EK
Sbjct: 2079 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-RLKQSAEEQAQARAQAQAAAEK 2137
Query: 325 LAVAKDRMMLQECRGTQQTDAMKTELVSENKVLREENDLEAG-NLHPQQDQSCLKECPCM 383
L + +Q A + + +E LR++ +A H + + L++ +
Sbjct: 2138 LR-----------KEAEQEAARRAQ--AEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2184
Query: 384 KGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEI 443
+ ++ T + ET++ K +E+L+++K + E + + Q+ + L V+ E+
Sbjct: 2185 E--QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ-RSQVEEELFS-VRVQMEEL 2240
Query: 444 KSVRSSVEAERKKLQREVEAQLEEVRKKSEKEIKQLEEEKAALNVKLQNSL-LEVLRLEE 502
+++ +EAE + L + + ++ +++KQ+ EE A L+V Q + L L E+
Sbjct: 2241 SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2300
Query: 503 FIQQNKTRPTGAEESPQELGRQHCSILETQDPCLKLDETSPRGEEYQDKLAAEEGT--SS 560
QQ +E Q + Q + L+ + L + Q +LA E+
Sbjct: 2301 LAQQRALAEKMLKEKMQAV--QEATRLKAEAELL----------QQQKELAQEQARRLQE 2348
Query: 561 DEEERTKVLLKEGSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQ-AQVSQMQQALEQC 619
D+E+ + L +E Q L + + ++LE ++++ KL+ A++S+ Q E
Sbjct: 2349 DKEQMAQQLAEETQGFQRTL------EAERQRQLEMSAEAERLKLRVAEMSRAQARAE-- 2400
Query: 620 TSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLEKARHQ--E 677
ED Q ++ ++ EKL R + TQ+ + LE Q++ E+ R E
Sbjct: 2401 -----EDAQRFRKQAEEIGEKLHRT-ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2454
Query: 678 LKATEERLKKESSHSLQIQHQTHRLELQALE-EKARQELQEERERMQAQQALLLESLRQE 736
L+ +E+L++E+ LQ++ + E+Q ++ E+ QE Q ++ +++ LL+ R
Sbjct: 2455 LEREKEKLQQEAK-LLQLKSE----EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF- 2508
Query: 737 LSEQQAACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGA 796
+ +++A +D A +LR QQ Q + ++A+ E Q + G
Sbjct: 2509 IEQEKAKLEQLFQDEVAKAQQLRE--EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2566
Query: 797 AGQGSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRAREVET 856
+ +LQ ++ R + E +E Q+LR+Q + LEE +A A E
Sbjct: 2567 R-----------RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2615
Query: 857 LRQEHRKEMQAMVADFSSAQAQLQARLAALEAELKDSGEKPGKGASR--------PEDLQ 908
+ A + + L A E E G + A R E+LQ
Sbjct: 2616 TASQ-----VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQ 2670
Query: 909 LIGRLQTRLKE---REDI 923
+ + T + E RED+
Sbjct: 2671 RLAQGHTTVDELARREDV 2688
Score = 122 bits (307), Expect = 1e-27
Identities = 165/741 (22%), Positives = 331/741 (44%), Gaps = 112/741 (15%)
Query: 51 ALNTRQDEAEASMEALRE---AHQEELQNAVAET---KARLLQEQGCAEEEALLQRIQAL 104
A +T + + +A +EA R+ A +EE + AE K+ +E+ + +A L+ ++ L
Sbjct: 1955 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2014
Query: 105 ESALELQKRLTEEALAESA-SCRLETKERELRVEAEHAERVLTLSREMLELKADYERRLQ 163
++ +E +RL E A ESA +L + + R++AE + ++ EL+ ++
Sbjct: 2015 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2074
Query: 164 HLTS--HEATPQGRLPQESPETKSEPG-QGPEMQEVLLEVQRLR--VENQQLSKDYARKA 218
L EA R +E+ E + + + + + + E +RL+ E Q ++ A+ A
Sbjct: 2075 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2134
Query: 219 EELQATYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEH 278
E + E E EA R+A Q+ AL Q Q ++++ K+ + E L+ Q ++E +L
Sbjct: 2135 AE-KLRKEAEQEAARRA--QAEQAALRQKQAADAEMEKHKKFAEQTLR-QKAQVEQELTT 2190
Query: 279 RGRKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECR 338
++ + L E +Q L + EA ++ S+++ E+L + +M
Sbjct: 2191 LRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE-------EELFSVRVQM------ 2237
Query: 339 GTQQTDAMKTELVSENK--VLREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEAS 396
++ +K + +EN+ +LR++++ T++
Sbjct: 2238 --EELSKLKARIEAENRALILRDKDN----------------------------TQRFLQ 2267
Query: 397 AETEYMKQQYEEDLR-KIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERK 455
E E MKQ EE R + Q + L + EDL ++ + K ++ ++A ++
Sbjct: 2268 EEAEKMKQVAEEAARLSVAAQEAARLRQLAE------EDLAQQRALAEKMLKEKMQAVQE 2321
Query: 456 KLQREVEAQLEEVRKK-SEKEIKQLEEEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGA 514
+ + EA+L + +K+ ++++ ++L+E+K + +L R E +Q +
Sbjct: 2322 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL----- 2376
Query: 515 EESPQELGRQHCSILETQDPCLKLDETSPR----GEEYQDKLAAEEGTSSDEEE--RTKV 568
E E R + E + +E + R EE +KL E + ++ +T
Sbjct: 2377 -EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2435
Query: 569 LLKEGSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQ-----------QALE 617
+ ++ SD L+E ++++R +E Q + LQ + +MQ QAL+
Sbjct: 2436 IQRQQSDHD---AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2492
Query: 618 QCTSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLEKARHQE 677
Q + ++ L ++ + E+ KL++ Q+ A QL QR + +E+ R +
Sbjct: 2493 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV----AKAQQLREEQQRQQQQMEQERQRL 2548
Query: 678 LKATEERLKKESSHSLQIQHQTHRLELQALEEKARQE---LQEERERMQAQQALLLESLR 734
+ + EE +++ H + + + ELQ LE++ RQ+ L EE +R++ Q L
Sbjct: 2549 VASMEEARRRQ--HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL------ 2600
Query: 735 QELSEQQAACSGHQKDLEALQ 755
L EQ A H +++ A Q
Sbjct: 2601 --LEEQHRAALAHSEEVTASQ 2619
Score = 108 bits (269), Expect = 3e-23
Identities = 212/1014 (20%), Positives = 408/1014 (40%), Gaps = 182/1014 (17%)
Query: 63 MEALREAHQEE--LQNAVAETKARLLQEQGCAEEEALLQRIQA-LESALELQKRLTEEAL 119
+++L + QEE Q ++E K LQ + C R+ E A E +R+ E+
Sbjct: 969 LQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQK 1028
Query: 120 AESASCRLETKERELRVEAE---------------HAERVLTLSR--EMLELKADYERRL 162
A++ L L EAE +E LTL + ++ L A Y +L
Sbjct: 1029 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1088
Query: 163 QHLTSHEATPQG-----RLPQES-PETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYAR 216
+ ++ QG R +E E ++ P PE++ +++LR + + +
Sbjct: 1089 KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1148
Query: 217 KAEELQATYE---------RENEAIRQAMQQSVSQALWQWQE-------KESDL------ 254
+EL+ E E + + ++ V+Q L +WQ ++ +L
Sbjct: 1149 LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ 1208
Query: 255 -------------------RKNFQVQ------ESALQAQVRKLEG---DLEHRGRKISDL 286
R+ Q+Q A++ Q+R+ + ++E G K+ +
Sbjct: 1209 LRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEEC 1268
Query: 287 KKYAQKLKERIQDLDVQLKEARQENSELKGTAKK----LGEKLAVAKD------------ 330
+++A++ I+D ++QL + + + AKK G + + +
Sbjct: 1269 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1328
Query: 331 -------------RMMLQECRGTQQTDAMKTELVSENKVLREENDLEAGNLHPQQDQSCL 377
R M +E R +Q A + E ++E + E+ + H Q
Sbjct: 1329 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKAQAE 1387
Query: 378 KECPCM--KGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEE------KKHLKDQLV 429
+E + + ++ ++EA+ + + K+ +E+L++++ +E E + ++
Sbjct: 1388 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1447
Query: 430 KRLEDLVKKHTVEIKSV---RSSVEAERKKLQ---REVEAQLEEVRKKSEKEIKQLEEE- 482
R+E+ ++ +++++ R E E + L+ E EAQ + ++++E+ +Q+++E
Sbjct: 1448 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1507
Query: 483 --KAALNVKLQNSL---LEVLR--------LEEFIQQNKTRPTGAEESPQELGRQHCSIL 529
K V+L + + E R LEE Q + ++ E RQ L
Sbjct: 1508 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1567
Query: 530 ETQDPCLKLDETSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLGSLLKEKTS 589
ET + + S R + +K A E S EE L+E ++ + + +
Sbjct: 1568 ETAQRSAEAELQSKRA-SFAEKTAQLE-RSLQEEHVAVAQLREEAERRAQQQAEAERARE 1625
Query: 590 KIQRLEEDWQ-----SQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQRE 644
+ +R E WQ + + +LQA+ Q++L Q +A KQ + ERE +R
Sbjct: 1626 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQA--------EAEKQKEEAEREARRRG 1677
Query: 645 LQETTQQNHAMKAQLEASHQRALRMLEKARHQELKATEE--RLKKESSHSLQIQHQTHRL 702
E A+ E QR ++ E Q L A +E RL+ E+ Q Q Q
Sbjct: 1678 KAEEQAVRQRELAEQELEKQR--QLAEGTAQQRLAAEQELIRLRAETEQGEQ-QRQLLEE 1734
Query: 703 ELQALEEKA------RQELQEERERMQAQQALLLESLRQELSEQQAACSGHQKDLEALQA 756
EL L+ +A RQEL+ E +++A+ +LL S + E ++ ++ LEA
Sbjct: 1735 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1794
Query: 757 ELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGAAGQ---GSGEGCGLWEENAQ 813
R L + A + + E Q + GE L +
Sbjct: 1795 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL---KTE 1851
Query: 814 LQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRAREVETLRQEHRK-------EMQ 866
+ A++ AE E+ ++ A+ QRR LEE Q AQ ++E + RK +
Sbjct: 1852 AEIALKEKEAENERLRRLAEDEAFQRRRLEE-QAAQHKADIEERLAQLRKASDSELERQK 1910
Query: 867 AMVADFSSAQAQLQARLAALEAELKDSGEKPGKGASRPEDLQL-IGRLQTRLKE 919
+V D + Q++ + AL+A + K A+ +L+L +GR+++ ++
Sbjct: 1911 GLVEDTLRQRRQVEEEILALKASFE-------KAAAGKAELELELGRIRSNAED 1957
Score = 66.6 bits (161), Expect = 1e-10
Identities = 87/381 (22%), Positives = 166/381 (43%), Gaps = 25/381 (6%)
Query: 56 QDEAEASMEALREAHQEEL---QNAVAETKARLLQEQGCAEEEALLQRIQALESALELQK 112
+++ +A EA R + EL Q +A+ +AR LQE + L + Q + LE ++
Sbjct: 2313 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2372
Query: 113 RLTEEALAESASCRLETKERELRVEAEHAERVLTLSREMLELKADYERRLQHLTSHEATP 172
+ E AE+ RL+ + E+ AE R+ E + R + T + T
Sbjct: 2373 QRQLEMSAEAE--RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2430
Query: 173 QGRLPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYARKAEELQATYERENEAI 232
L + ++ + ++E + E++R + + QQ +K K+EE+Q + +
Sbjct: 2431 VQTLEIQRQQSDHD---AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2487
Query: 233 RQAMQQSVSQALWQWQEKESDL-RKNFQVQESALQAQVRKLEGDLEHRGRKISDLKKYAQ 291
QA+QQS EK+S L R+ F QE A Q+ + ++ + + ++ Q
Sbjct: 2488 TQALQQSF------LSEKDSLLQRERFIEQEKAKLEQL--FQDEVAKAQQLREEQQRQQQ 2539
Query: 292 KLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECRGTQQTDAMKTELV 351
++++ Q L ++EAR+ E + ++ E+L + + Q+ R ++ A + + +
Sbjct: 2540 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL-----QQLEQQRRQQEELLAEENQRL 2594
Query: 352 SENKVLREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEASAETEYMKQQYEEDLR 411
E L EE A + S + + G D A AE E+ ++ R
Sbjct: 2595 REQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEH---SFDGLRR 2651
Query: 412 KIKHQTEEEKKHLKDQLVKRL 432
K+ Q +E L + ++RL
Sbjct: 2652 KVSAQRLQEAGILSAEELQRL 2672
Score = 55.5 bits (132), Expect = 3e-07
Identities = 114/568 (20%), Positives = 238/568 (41%), Gaps = 38/568 (6%)
Query: 385 GGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDL-VKKHTVEI 443
GG + + A E Y++ L+ ++ +EE + + + L+D+ ++ E
Sbjct: 944 GGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRC--QRCISELKDIRLQLEACET 1001
Query: 444 KSVRSSVEAERKKLQREVEAQLEEVRKKSEKEIKQLEEEKAALNVKLQN--SLLEVLRLE 501
++V K+ RE ++ E ++K++ E++ L + A L+ + + +L E
Sbjct: 1002 RTVHRLRLPLDKEPARECAQRIAE-QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAA 1060
Query: 502 EFIQQNKTRPTGAEESPQELGRQHCSILETQDPCLKLDETSP---RGEEYQDKLAAEEGT 558
++ G E + L + L+T ++ + + R E Q K A
Sbjct: 1061 PTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1120
Query: 559 SSDEEERTKVLLKE---GSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQQA 615
+ E E TK LK+ ++ Q P L+++ Q + E Q + + +V + ++
Sbjct: 1121 TLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1180
Query: 616 LEQCTSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLEKARH 675
+ Q ++ L A + E E+L R+L+ + + A L+ + +R ++
Sbjct: 1181 VAQLLERWQAVL-AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ-EQIQAMPL 1238
Query: 676 QELKATEERLKKESSHSLQIQHQTHRLE-LQALEEKARQELQEERERMQAQQALL--LES 732
+ +A E+L++E + +I+ ++E Q ++ +++ ++ +A L + S
Sbjct: 1239 ADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVAS 1298
Query: 733 LRQELSEQQAACSGHQK--DLEALQAELRALGRQQA---SSQCPGDSKDHIIATEERGGP 787
++ Q + S Q+ DL +EL L Q S ++ +A ++R
Sbjct: 1299 PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE 1358
Query: 788 GQAGSPPGAAGQGSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQ 847
+ + AA + + L E +AQ + R E++Q QE R++ + Q+
Sbjct: 1359 RERLAEVEAALEKQRQ---LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1415
Query: 848 AQRAREVETLRQEHRKEMQAM-----VADFSSAQAQLQARLAALEAELKDSGEKPGKGAS 902
E++ LRQ E+QA A+ S + + + R+ L+ E + +G
Sbjct: 1416 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG-- 1473
Query: 903 RPEDLQLIGRLQTRLKEREDIIKQLTEE 930
+LQ L+ R +E E +Q EE
Sbjct: 1474 ---ELQ---ALRARAEEAEAQKRQAQEE 1495
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 142 bits (358), Expect = 2e-33
Identities = 228/975 (23%), Positives = 427/975 (43%), Gaps = 117/975 (12%)
Query: 55 RQDEAEASMEALREAHQEEL----QNAVAETKARLLQEQGC------AEEEALLQRIQ-- 102
R++EA + + + QEEL Q++ AE +A+ Q + EEE + R+Q
Sbjct: 1371 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1430
Query: 103 -------ALESALELQKRLTEEALAESASCRLETKERELRVEAEHAERVLTLSREMLELK 155
E L+ + EEA A+ + E + +V+ E + +K
Sbjct: 1431 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1490
Query: 156 ADYERRLQHLTSHEATPQGRLPQESPETK---SEPGQGPEMQEVLLEVQR-LRVENQQLS 211
A+ E + + +A + RL E E + +E + ++Q L QR E Q
Sbjct: 1491 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1550
Query: 212 KDYARKAEELQATYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRK 271
+A K +L+ + + E+ A+ Q +++ +A Q Q A +A+ +
Sbjct: 1551 ASFAEKTAQLERSLQEEHVAVAQLREEAERRA---------------QQQAEAERAR-EE 1594
Query: 272 LEGDLEHRGRKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLG--EKLAVAK 329
E +LE K ++ + + +E Q + EA ++ E + A++ G E+ AV +
Sbjct: 1595 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1654
Query: 330 DRMMLQECRGTQQ--TDAMKTELVSENKVLREENDLEAGNLHPQQDQSCLKECPCMKGGT 387
+ QE +Q + L +E +++R + E G QQ Q +E ++
Sbjct: 1655 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE---QQRQLLEEELARLQREA 1711
Query: 388 DMQTKKEASAETEYMKQQYE-EDLRKIKHQTEEEKKHLKDQLVKRLE-DLVKKHTVEIKS 445
T+K E E K + E E L K + EEE + ++ +RLE + + + ++
Sbjct: 1712 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1771
Query: 446 VRSSVEAERKKLQREVEAQLEEVRKKSEKEIKQLEEEKAALNVKLQNSLLEVLRLEEFIQ 505
R AE K QR++ A+ + R+++E E + L E+ AA+ + + L+E
Sbjct: 1772 ARLRALAEEAKRQRQL-AEEDAARQRAEAE-RVLAEKLAAIGEATRLKTEAEIALKEKEA 1829
Query: 506 QNKTRPTGAEESPQELGRQHCSILETQDPCLKLDETSPRGEEYQDKLAAEEGTSSDEEER 565
+N+ AE+ + R LE Q K D +++LA S E ER
Sbjct: 1830 ENERLRRLAEDEAFQRRR-----LEEQAAQHKAD--------IEERLAQLRKASDSELER 1876
Query: 566 TKVLLKEGSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQ-QALEQCTSNYR 624
K L+++ + ++E+ ++ E + KA+L+ ++ +++ A + S +
Sbjct: 1877 QKGLVEDTLRQR----RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ 1932
Query: 625 EDLQALKQLS-DLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLE--KARHQELKAT 681
+L+A +Q E E+ +RE +E Q++ A + + + AL +E KA+ +E +
Sbjct: 1933 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRL 1992
Query: 682 EERLKKESSHSLQIQHQTHRLELQALEEKAR----QELQEERERMQAQQALLLESLRQEL 737
ER ++ES+ LQ+ + + LQA EEKA Q+ ++E ++ Q+ +L+ LR E
Sbjct: 1993 RERAEQESARQLQLAQEAAQKRLQA-EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2051
Query: 738 SEQQAACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGAA 797
+ A EA +A ++A R+ A S+ + + + + E + A
Sbjct: 2052 EAARRAAE------EAEEARVQA-EREAAQSRRQVEEAERLKQSAEEQAQAR------AQ 2098
Query: 798 GQGSGEGCGLWEENAQLQDAVRRLRAE---VEQHQQEAQKLRDQRRFLEET--QQAQRAR 852
Q + E E Q+A RR +AE + Q Q ++ ++F E+T Q+AQ +
Sbjct: 2099 AQAAAEKLRKEAE----QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2154
Query: 853 EVETLR-----QEHRK-----EMQAMVADFSSA---QAQLQARLAALEAELKDSGEKPGK 899
E+ TLR +H+K E+Q + A+ + A ++Q++ L ++ ++++ + K
Sbjct: 2155 ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL--K 2212
Query: 900 GASRPEDLQLIGR----LQTRLKEREDIIKQLTEERRFHYAAFPSAMSHRNRSFSFNPHP 955
E+ LI R Q L+E + +KQ+ EE A A R +
Sbjct: 2213 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2272
Query: 956 GYLTPSMKKKKVEDV 970
L M K+K++ V
Sbjct: 2273 RALAEKMLKEKMQAV 2287
Score = 138 bits (348), Expect = 2e-32
Identities = 222/971 (22%), Positives = 413/971 (42%), Gaps = 141/971 (14%)
Query: 47 KVIYALNTRQDEAEASMEALREAHQEELQNAVAETKARLLQEQGCAEEEALLQRIQALES 106
+ + AL + +AE + LR+A E + + + L Q AE E +R E
Sbjct: 1501 RALQALEELRLQAEEAERRLRQAEVERAR----QVQVALETAQRSAEAELQSKRASFAEK 1556
Query: 107 ALELQKRLTEEALAESASCRLETKER-ELRVEAEHAERVLTLSREMLELKADYERRLQHL 165
+L++ L EE +A A R E + R + + EAE A E +LKA+ RL+ L
Sbjct: 1557 TAQLERSLQEEHVA-VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR-L 1614
Query: 166 TSHEATPQGRLPQESPETKSEPGQGPEMQEVLLEVQRLR---VENQQLSKDYARKAEELQ 222
+ E Q L Q E + E + + E Q +R + Q+L K Q
Sbjct: 1615 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1674
Query: 223 ATYERENEAIR--------QAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEG 274
E E IR + +Q + + L + Q + + + Q E+ L ++E
Sbjct: 1675 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1734
Query: 275 DLEHRGRKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAK----- 329
L + R + + ++K K+R++ + +E +E + L+ A++ + +A+
Sbjct: 1735 LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR 1794
Query: 330 -----DRMMLQECRGTQQTDAMKTEL-------VSENKVLREENDLEAGNLHPQQDQSCL 377
+R++ ++ + +KTE +EN+ LR + EA ++Q+
Sbjct: 1795 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ 1854
Query: 378 KECPCMKGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVK------- 430
+ + Q +K + +E E K E+ LR+ + Q EEE LK K
Sbjct: 1855 HKADIEE--RLAQLRKASDSELERQKGLVEDTLRQ-RRQVEEEILALKASFEKAAAGKAE 1911
Query: 431 ----------RLEDLVK-KHTVEIKSVRS-SVEAERKKLQREVEAQLEEVRKKSEKEIKQ 478
ED ++ K E+++ R + AE ++ +RE E E V+K E +
Sbjct: 1912 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE---ERVQKSLAAEEEA 1968
Query: 479 LEEEKAALN--VKLQNSLLEVLRLEEFIQQNKTRPTG-AEESPQE--LGRQHCSILETQD 533
+ KAAL +L+ + E RL E +Q R A+E+ Q+ + Q
Sbjct: 1969 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2028
Query: 534 PCLKLDETSPRGEEYQDKLAAEEGT---SSDEEERTKVLLKEGSDPQPPLGSLLKEKTSK 590
+L +T + + D+L E +++E E +V ++ + E+ +
Sbjct: 2029 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV----QAEREAAQSRRQVEEAER 2084
Query: 591 IQRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQAL---KQLSDLEREKLQRELQE 647
+++ E+ +A+ QA ++++ EQ + + QA KQ +D E EK ++ ++
Sbjct: 2085 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2144
Query: 648 TTQQNHAMKAQLEASHQRALRMLEKARHQELKATEE--RLKKESSHSLQIQHQTH----- 700
T +Q KAQ+E LE+ HQ+ EE RLK E++ + + + Q
Sbjct: 2145 TLRQ----KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2200
Query: 701 -RLELQALEE-KARQE-----------------LQEERERMQ--AQQALLLESLRQELSE 739
R++++ L + KAR E LQEE E+M+ A++A L QE +
Sbjct: 2201 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2260
Query: 740 QQAACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGAAGQ 799
+ ++DL A+ RAL + K+ + A +E A +
Sbjct: 2261 LRQLA---EEDL----AQQRALAEKML--------KEKMQAVQE-------------ATR 2292
Query: 800 GSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRAREVETLRQ 859
E L ++ Q+ RRL+ E +Q AQ+L ++ + + T +A+R R++E +
Sbjct: 2293 LKAEAELLQQQKELAQEQARRLQ---EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2349
Query: 860 EHRKEMQAMVADFSSAQAQLQARLAALEAELKDSGEKPGK-GASRPEDLQLIGRLQTRLK 918
R +++ VA+ S AQA+ + + ++ GEK + + E + L+ L+ + +
Sbjct: 2350 AERLKLR--VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ 2407
Query: 919 EREDIIKQLTE 929
+ + ++L E
Sbjct: 2408 QSDHDAERLRE 2418
Score = 128 bits (322), Expect = 2e-29
Identities = 206/918 (22%), Positives = 397/918 (43%), Gaps = 132/918 (14%)
Query: 58 EAEASMEALREAHQEELQNAVAETKA---RLLQEQGCAE----EEALLQRIQALESALEL 110
EAE +++ +EA E L+ +AE +A R L+EQ EE L Q +A +S LE
Sbjct: 1819 EAEIALKE-KEAENERLRR-LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1876
Query: 111 QKRLTEEAL-------------------AESASCRLETKERELRVEAEHAERVLTLSREM 151
QK L E+ L A + LE + +R AE R S+E
Sbjct: 1877 QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR----SKEQ 1932
Query: 152 LELKADYERRLQHLTSHEATPQGRLPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLS 211
EL+A +R+L Q+S + E + + + L EV+RL+ + ++
Sbjct: 1933 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR--QRKAALEEVERLKAKVEEAR 1990
Query: 212 KDYARKAEELQATYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRK 271
+ R +E + EA ++ +Q + Q+KE +L++ Q ++S L +
Sbjct: 1991 RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD----Q 2046
Query: 272 LEGDLEHRGRKISDLK-------KYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEK 324
L G+ E R + + + A + + ++++ + +LK++ +E ++ + A+ EK
Sbjct: 2047 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-RLKQSAEEQAQARAQAQAAAEK 2105
Query: 325 LAVAKDRMMLQECRGTQQTDAMKTELVSENKVLREENDLEAG-NLHPQQDQSCLKECPCM 383
L + +Q A + + +E LR++ +A H + + L++ +
Sbjct: 2106 LR-----------KEAEQEAARRAQ--AEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2152
Query: 384 KGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEI 443
+ ++ T + ET++ K +E+L+++K + E + + Q+ + L V+ E+
Sbjct: 2153 E--QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ-RSQVEEELFS-VRVQMEEL 2208
Query: 444 KSVRSSVEAERKKLQREVEAQLEEVRKKSEKEIKQLEEEKAALNVKLQNSL-LEVLRLEE 502
+++ +EAE + L + + ++ +++KQ+ EE A L+V Q + L L E+
Sbjct: 2209 SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2268
Query: 503 FIQQNKTRPTGAEESPQELGRQHCSILETQDPCLKLDETSPRGEEYQDKLAAEEGT--SS 560
QQ +E Q + Q + L+ + L + Q +LA E+
Sbjct: 2269 LAQQRALAEKMLKEKMQAV--QEATRLKAEAELL----------QQQKELAQEQARRLQE 2316
Query: 561 DEEERTKVLLKEGSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQ-AQVSQMQQALEQC 619
D+E+ + L +E Q L + + ++LE ++++ KL+ A++S+ Q E
Sbjct: 2317 DKEQMAQQLAEETQGFQRTL------EAERQRQLEMSAEAERLKLRVAEMSRAQARAE-- 2368
Query: 620 TSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLEKARHQ--E 677
ED Q ++ ++ EKL R + TQ+ + LE Q++ E+ R E
Sbjct: 2369 -----EDAQRFRKQAEEIGEKLHRT-ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2422
Query: 678 LKATEERLKKESSHSLQIQHQTHRLELQALE-EKARQELQEERERMQAQQALLLESLRQE 736
L+ +E+L++E+ LQ++ + E+Q ++ E+ QE Q ++ +++ LL+ R
Sbjct: 2423 LEREKEKLQQEAK-LLQLKSE----EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF- 2476
Query: 737 LSEQQAACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGA 796
+ +++A +D A +LR QQ Q + ++A+ E Q + G
Sbjct: 2477 IEQEKAKLEQLFQDEVAKAQQLRE--EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2534
Query: 797 AGQGSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRAREVET 856
+ +LQ ++ R + E +E Q+LR+Q + LEE +A A E
Sbjct: 2535 R-----------RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2583
Query: 857 LRQEHRKEMQAMVADFSSAQAQLQARLAALEAELKDSGEKPGKGASR--------PEDLQ 908
+ A + + L A E E G + A R E+LQ
Sbjct: 2584 TASQ-----VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQ 2638
Query: 909 LIGRLQTRLKE---REDI 923
+ + T + E RED+
Sbjct: 2639 RLAQGHTTVDELARREDV 2656
Score = 122 bits (307), Expect = 1e-27
Identities = 165/741 (22%), Positives = 331/741 (44%), Gaps = 112/741 (15%)
Query: 51 ALNTRQDEAEASMEALRE---AHQEELQNAVAET---KARLLQEQGCAEEEALLQRIQAL 104
A +T + + +A +EA R+ A +EE + AE K+ +E+ + +A L+ ++ L
Sbjct: 1923 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 1982
Query: 105 ESALELQKRLTEEALAESA-SCRLETKERELRVEAEHAERVLTLSREMLELKADYERRLQ 163
++ +E +RL E A ESA +L + + R++AE + ++ EL+ ++
Sbjct: 1983 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2042
Query: 164 HLTS--HEATPQGRLPQESPETKSEPG-QGPEMQEVLLEVQRLR--VENQQLSKDYARKA 218
L EA R +E+ E + + + + + + E +RL+ E Q ++ A+ A
Sbjct: 2043 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2102
Query: 219 EELQATYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEH 278
E + E E EA R+A Q+ AL Q Q ++++ K+ + E L+ Q ++E +L
Sbjct: 2103 AE-KLRKEAEQEAARRA--QAEQAALRQKQAADAEMEKHKKFAEQTLR-QKAQVEQELTT 2158
Query: 279 RGRKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECR 338
++ + L E +Q L + EA ++ S+++ E+L + +M
Sbjct: 2159 LRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE-------EELFSVRVQM------ 2205
Query: 339 GTQQTDAMKTELVSENK--VLREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEAS 396
++ +K + +EN+ +LR++++ T++
Sbjct: 2206 --EELSKLKARIEAENRALILRDKDN----------------------------TQRFLQ 2235
Query: 397 AETEYMKQQYEEDLR-KIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERK 455
E E MKQ EE R + Q + L + EDL ++ + K ++ ++A ++
Sbjct: 2236 EEAEKMKQVAEEAARLSVAAQEAARLRQLAE------EDLAQQRALAEKMLKEKMQAVQE 2289
Query: 456 KLQREVEAQLEEVRKK-SEKEIKQLEEEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGA 514
+ + EA+L + +K+ ++++ ++L+E+K + +L R E +Q +
Sbjct: 2290 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL----- 2344
Query: 515 EESPQELGRQHCSILETQDPCLKLDETSPR----GEEYQDKLAAEEGTSSDEEE--RTKV 568
E E R + E + +E + R EE +KL E + ++ +T
Sbjct: 2345 -EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2403
Query: 569 LLKEGSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQ-----------QALE 617
+ ++ SD L+E ++++R +E Q + LQ + +MQ QAL+
Sbjct: 2404 IQRQQSDHD---AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2460
Query: 618 QCTSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLEKARHQE 677
Q + ++ L ++ + E+ KL++ Q+ A QL QR + +E+ R +
Sbjct: 2461 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV----AKAQQLREEQQRQQQQMEQERQRL 2516
Query: 678 LKATEERLKKESSHSLQIQHQTHRLELQALEEKARQE---LQEERERMQAQQALLLESLR 734
+ + EE +++ H + + + ELQ LE++ RQ+ L EE +R++ Q L
Sbjct: 2517 VASMEEARRRQ--HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL------ 2568
Query: 735 QELSEQQAACSGHQKDLEALQ 755
L EQ A H +++ A Q
Sbjct: 2569 --LEEQHRAALAHSEEVTASQ 2587
Score = 108 bits (269), Expect = 3e-23
Identities = 212/1014 (20%), Positives = 408/1014 (40%), Gaps = 182/1014 (17%)
Query: 63 MEALREAHQEE--LQNAVAETKARLLQEQGCAEEEALLQRIQA-LESALELQKRLTEEAL 119
+++L + QEE Q ++E K LQ + C R+ E A E +R+ E+
Sbjct: 937 LQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQK 996
Query: 120 AESASCRLETKERELRVEAE---------------HAERVLTLSR--EMLELKADYERRL 162
A++ L L EAE +E LTL + ++ L A Y +L
Sbjct: 997 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1056
Query: 163 QHLTSHEATPQG-----RLPQES-PETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYAR 216
+ ++ QG R +E E ++ P PE++ +++LR + + +
Sbjct: 1057 KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1116
Query: 217 KAEELQATYE---------RENEAIRQAMQQSVSQALWQWQE-------KESDL------ 254
+EL+ E E + + ++ V+Q L +WQ ++ +L
Sbjct: 1117 LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ 1176
Query: 255 -------------------RKNFQVQ------ESALQAQVRKLEG---DLEHRGRKISDL 286
R+ Q+Q A++ Q+R+ + ++E G K+ +
Sbjct: 1177 LRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEEC 1236
Query: 287 KKYAQKLKERIQDLDVQLKEARQENSELKGTAKK----LGEKLAVAKD------------ 330
+++A++ I+D ++QL + + + AKK G + + +
Sbjct: 1237 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1296
Query: 331 -------------RMMLQECRGTQQTDAMKTELVSENKVLREENDLEAGNLHPQQDQSCL 377
R M +E R +Q A + E ++E + E+ + H Q
Sbjct: 1297 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKAQAE 1355
Query: 378 KECPCM--KGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEE------KKHLKDQLV 429
+E + + ++ ++EA+ + + K+ +E+L++++ +E E + ++
Sbjct: 1356 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1415
Query: 430 KRLEDLVKKHTVEIKSV---RSSVEAERKKLQ---REVEAQLEEVRKKSEKEIKQLEEE- 482
R+E+ ++ +++++ R E E + L+ E EAQ + ++++E+ +Q+++E
Sbjct: 1416 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1475
Query: 483 --KAALNVKLQNSL---LEVLR--------LEEFIQQNKTRPTGAEESPQELGRQHCSIL 529
K V+L + + E R LEE Q + ++ E RQ L
Sbjct: 1476 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1535
Query: 530 ETQDPCLKLDETSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLGSLLKEKTS 589
ET + + S R + +K A E S EE L+E ++ + + +
Sbjct: 1536 ETAQRSAEAELQSKRA-SFAEKTAQLE-RSLQEEHVAVAQLREEAERRAQQQAEAERARE 1593
Query: 590 KIQRLEEDWQ-----SQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQRE 644
+ +R E WQ + + +LQA+ Q++L Q +A KQ + ERE +R
Sbjct: 1594 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQA--------EAEKQKEEAEREARRRG 1645
Query: 645 LQETTQQNHAMKAQLEASHQRALRMLEKARHQELKATEE--RLKKESSHSLQIQHQTHRL 702
E A+ E QR ++ E Q L A +E RL+ E+ Q Q Q
Sbjct: 1646 KAEEQAVRQRELAEQELEKQR--QLAEGTAQQRLAAEQELIRLRAETEQGEQ-QRQLLEE 1702
Query: 703 ELQALEEKA------RQELQEERERMQAQQALLLESLRQELSEQQAACSGHQKDLEALQA 756
EL L+ +A RQEL+ E +++A+ +LL S + E ++ ++ LEA
Sbjct: 1703 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1762
Query: 757 ELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGAAGQ---GSGEGCGLWEENAQ 813
R L + A + + E Q + GE L +
Sbjct: 1763 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL---KTE 1819
Query: 814 LQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRAREVETLRQEHRK-------EMQ 866
+ A++ AE E+ ++ A+ QRR LEE Q AQ ++E + RK +
Sbjct: 1820 AEIALKEKEAENERLRRLAEDEAFQRRRLEE-QAAQHKADIEERLAQLRKASDSELERQK 1878
Query: 867 AMVADFSSAQAQLQARLAALEAELKDSGEKPGKGASRPEDLQL-IGRLQTRLKE 919
+V D + Q++ + AL+A + K A+ +L+L +GR+++ ++
Sbjct: 1879 GLVEDTLRQRRQVEEEILALKASFE-------KAAAGKAELELELGRIRSNAED 1925
Score = 66.6 bits (161), Expect = 1e-10
Identities = 87/381 (22%), Positives = 166/381 (43%), Gaps = 25/381 (6%)
Query: 56 QDEAEASMEALREAHQEEL---QNAVAETKARLLQEQGCAEEEALLQRIQALESALELQK 112
+++ +A EA R + EL Q +A+ +AR LQE + L + Q + LE ++
Sbjct: 2281 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2340
Query: 113 RLTEEALAESASCRLETKERELRVEAEHAERVLTLSREMLELKADYERRLQHLTSHEATP 172
+ E AE+ RL+ + E+ AE R+ E + R + T + T
Sbjct: 2341 QRQLEMSAEAE--RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2398
Query: 173 QGRLPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYARKAEELQATYERENEAI 232
L + ++ + ++E + E++R + + QQ +K K+EE+Q + +
Sbjct: 2399 VQTLEIQRQQSDHD---AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2455
Query: 233 RQAMQQSVSQALWQWQEKESDL-RKNFQVQESALQAQVRKLEGDLEHRGRKISDLKKYAQ 291
QA+QQS EK+S L R+ F QE A Q+ + ++ + + ++ Q
Sbjct: 2456 TQALQQSF------LSEKDSLLQRERFIEQEKAKLEQL--FQDEVAKAQQLREEQQRQQQ 2507
Query: 292 KLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECRGTQQTDAMKTELV 351
++++ Q L ++EAR+ E + ++ E+L + + Q+ R ++ A + + +
Sbjct: 2508 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL-----QQLEQQRRQQEELLAEENQRL 2562
Query: 352 SENKVLREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEASAETEYMKQQYEEDLR 411
E L EE A + S + + G D A AE E+ ++ R
Sbjct: 2563 REQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEH---SFDGLRR 2619
Query: 412 KIKHQTEEEKKHLKDQLVKRL 432
K+ Q +E L + ++RL
Sbjct: 2620 KVSAQRLQEAGILSAEELQRL 2640
Score = 55.5 bits (132), Expect = 3e-07
Identities = 114/568 (20%), Positives = 238/568 (41%), Gaps = 38/568 (6%)
Query: 385 GGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDL-VKKHTVEI 443
GG + + A E Y++ L+ ++ +EE + + + L+D+ ++ E
Sbjct: 912 GGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRC--QRCISELKDIRLQLEACET 969
Query: 444 KSVRSSVEAERKKLQREVEAQLEEVRKKSEKEIKQLEEEKAALNVKLQN--SLLEVLRLE 501
++V K+ RE ++ E ++K++ E++ L + A L+ + + +L E
Sbjct: 970 RTVHRLRLPLDKEPARECAQRIAE-QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAA 1028
Query: 502 EFIQQNKTRPTGAEESPQELGRQHCSILETQDPCLKLDETSP---RGEEYQDKLAAEEGT 558
++ G E + L + L+T ++ + + R E Q K A
Sbjct: 1029 PTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1088
Query: 559 SSDEEERTKVLLKE---GSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQQA 615
+ E E TK LK+ ++ Q P L+++ Q + E Q + + +V + ++
Sbjct: 1089 TLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1148
Query: 616 LEQCTSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLEKARH 675
+ Q ++ L A + E E+L R+L+ + + A L+ + +R ++
Sbjct: 1149 VAQLLERWQAVL-AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ-EQIQAMPL 1206
Query: 676 QELKATEERLKKESSHSLQIQHQTHRLE-LQALEEKARQELQEERERMQAQQALL--LES 732
+ +A E+L++E + +I+ ++E Q ++ +++ ++ +A L + S
Sbjct: 1207 ADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVAS 1266
Query: 733 LRQELSEQQAACSGHQK--DLEALQAELRALGRQQA---SSQCPGDSKDHIIATEERGGP 787
++ Q + S Q+ DL +EL L Q S ++ +A ++R
Sbjct: 1267 PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE 1326
Query: 788 GQAGSPPGAAGQGSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQ 847
+ + AA + + L E +AQ + R E++Q QE R++ + Q+
Sbjct: 1327 RERLAEVEAALEKQRQ---LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1383
Query: 848 AQRAREVETLRQEHRKEMQAM-----VADFSSAQAQLQARLAALEAELKDSGEKPGKGAS 902
E++ LRQ E+QA A+ S + + + R+ L+ E + +G
Sbjct: 1384 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG-- 1441
Query: 903 RPEDLQLIGRLQTRLKEREDIIKQLTEE 930
+LQ L+ R +E E +Q EE
Sbjct: 1442 ---ELQ---ALRARAEEAEAQKRQAQEE 1463
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 142 bits (358), Expect = 2e-33
Identities = 228/975 (23%), Positives = 427/975 (43%), Gaps = 117/975 (12%)
Query: 55 RQDEAEASMEALREAHQEEL----QNAVAETKARLLQEQGC------AEEEALLQRIQ-- 102
R++EA + + + QEEL Q++ AE +A+ Q + EEE + R+Q
Sbjct: 1540 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1599
Query: 103 -------ALESALELQKRLTEEALAESASCRLETKERELRVEAEHAERVLTLSREMLELK 155
E L+ + EEA A+ + E + +V+ E + +K
Sbjct: 1600 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1659
Query: 156 ADYERRLQHLTSHEATPQGRLPQESPETK---SEPGQGPEMQEVLLEVQR-LRVENQQLS 211
A+ E + + +A + RL E E + +E + ++Q L QR E Q
Sbjct: 1660 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1719
Query: 212 KDYARKAEELQATYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRK 271
+A K +L+ + + E+ A+ Q +++ +A Q Q A +A+ +
Sbjct: 1720 ASFAEKTAQLERSLQEEHVAVAQLREEAERRA---------------QQQAEAERAR-EE 1763
Query: 272 LEGDLEHRGRKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLG--EKLAVAK 329
E +LE K ++ + + +E Q + EA ++ E + A++ G E+ AV +
Sbjct: 1764 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1823
Query: 330 DRMMLQECRGTQQ--TDAMKTELVSENKVLREENDLEAGNLHPQQDQSCLKECPCMKGGT 387
+ QE +Q + L +E +++R + E G QQ Q +E ++
Sbjct: 1824 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE---QQRQLLEEELARLQREA 1880
Query: 388 DMQTKKEASAETEYMKQQYE-EDLRKIKHQTEEEKKHLKDQLVKRLE-DLVKKHTVEIKS 445
T+K E E K + E E L K + EEE + ++ +RLE + + + ++
Sbjct: 1881 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1940
Query: 446 VRSSVEAERKKLQREVEAQLEEVRKKSEKEIKQLEEEKAALNVKLQNSLLEVLRLEEFIQ 505
R AE K QR++ A+ + R+++E E + L E+ AA+ + + L+E
Sbjct: 1941 ARLRALAEEAKRQRQL-AEEDAARQRAEAE-RVLAEKLAAIGEATRLKTEAEIALKEKEA 1998
Query: 506 QNKTRPTGAEESPQELGRQHCSILETQDPCLKLDETSPRGEEYQDKLAAEEGTSSDEEER 565
+N+ AE+ + R LE Q K D +++LA S E ER
Sbjct: 1999 ENERLRRLAEDEAFQRRR-----LEEQAAQHKAD--------IEERLAQLRKASDSELER 2045
Query: 566 TKVLLKEGSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQ-QALEQCTSNYR 624
K L+++ + ++E+ ++ E + KA+L+ ++ +++ A + S +
Sbjct: 2046 QKGLVEDTLRQR----RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ 2101
Query: 625 EDLQALKQLS-DLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLE--KARHQELKAT 681
+L+A +Q E E+ +RE +E Q++ A + + + AL +E KA+ +E +
Sbjct: 2102 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRL 2161
Query: 682 EERLKKESSHSLQIQHQTHRLELQALEEKAR----QELQEERERMQAQQALLLESLRQEL 737
ER ++ES+ LQ+ + + LQA EEKA Q+ ++E ++ Q+ +L+ LR E
Sbjct: 2162 RERAEQESARQLQLAQEAAQKRLQA-EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2220
Query: 738 SEQQAACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGAA 797
+ A EA +A ++A R+ A S+ + + + + E + A
Sbjct: 2221 EAARRAAE------EAEEARVQA-EREAAQSRRQVEEAERLKQSAEEQAQAR------AQ 2267
Query: 798 GQGSGEGCGLWEENAQLQDAVRRLRAE---VEQHQQEAQKLRDQRRFLEET--QQAQRAR 852
Q + E E Q+A RR +AE + Q Q ++ ++F E+T Q+AQ +
Sbjct: 2268 AQAAAEKLRKEAE----QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2323
Query: 853 EVETLR-----QEHRK-----EMQAMVADFSSA---QAQLQARLAALEAELKDSGEKPGK 899
E+ TLR +H+K E+Q + A+ + A ++Q++ L ++ ++++ + K
Sbjct: 2324 ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL--K 2381
Query: 900 GASRPEDLQLIGR----LQTRLKEREDIIKQLTEERRFHYAAFPSAMSHRNRSFSFNPHP 955
E+ LI R Q L+E + +KQ+ EE A A R +
Sbjct: 2382 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2441
Query: 956 GYLTPSMKKKKVEDV 970
L M K+K++ V
Sbjct: 2442 RALAEKMLKEKMQAV 2456
Score = 138 bits (348), Expect = 2e-32
Identities = 222/971 (22%), Positives = 413/971 (42%), Gaps = 141/971 (14%)
Query: 47 KVIYALNTRQDEAEASMEALREAHQEELQNAVAETKARLLQEQGCAEEEALLQRIQALES 106
+ + AL + +AE + LR+A E + + + L Q AE E +R E
Sbjct: 1670 RALQALEELRLQAEEAERRLRQAEVERAR----QVQVALETAQRSAEAELQSKRASFAEK 1725
Query: 107 ALELQKRLTEEALAESASCRLETKER-ELRVEAEHAERVLTLSREMLELKADYERRLQHL 165
+L++ L EE +A A R E + R + + EAE A E +LKA+ RL+ L
Sbjct: 1726 TAQLERSLQEEHVA-VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR-L 1783
Query: 166 TSHEATPQGRLPQESPETKSEPGQGPEMQEVLLEVQRLR---VENQQLSKDYARKAEELQ 222
+ E Q L Q E + E + + E Q +R + Q+L K Q
Sbjct: 1784 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1843
Query: 223 ATYERENEAIR--------QAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEG 274
E E IR + +Q + + L + Q + + + Q E+ L ++E
Sbjct: 1844 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1903
Query: 275 DLEHRGRKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAK----- 329
L + R + + ++K K+R++ + +E +E + L+ A++ + +A+
Sbjct: 1904 LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR 1963
Query: 330 -----DRMMLQECRGTQQTDAMKTEL-------VSENKVLREENDLEAGNLHPQQDQSCL 377
+R++ ++ + +KTE +EN+ LR + EA ++Q+
Sbjct: 1964 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ 2023
Query: 378 KECPCMKGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVK------- 430
+ + Q +K + +E E K E+ LR+ + Q EEE LK K
Sbjct: 2024 HKADIEE--RLAQLRKASDSELERQKGLVEDTLRQ-RRQVEEEILALKASFEKAAAGKAE 2080
Query: 431 ----------RLEDLVK-KHTVEIKSVRS-SVEAERKKLQREVEAQLEEVRKKSEKEIKQ 478
ED ++ K E+++ R + AE ++ +RE E E V+K E +
Sbjct: 2081 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE---ERVQKSLAAEEEA 2137
Query: 479 LEEEKAALN--VKLQNSLLEVLRLEEFIQQNKTRPTG-AEESPQE--LGRQHCSILETQD 533
+ KAAL +L+ + E RL E +Q R A+E+ Q+ + Q
Sbjct: 2138 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2197
Query: 534 PCLKLDETSPRGEEYQDKLAAEEGT---SSDEEERTKVLLKEGSDPQPPLGSLLKEKTSK 590
+L +T + + D+L E +++E E +V ++ + E+ +
Sbjct: 2198 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV----QAEREAAQSRRQVEEAER 2253
Query: 591 IQRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQAL---KQLSDLEREKLQRELQE 647
+++ E+ +A+ QA ++++ EQ + + QA KQ +D E EK ++ ++
Sbjct: 2254 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2313
Query: 648 TTQQNHAMKAQLEASHQRALRMLEKARHQELKATEE--RLKKESSHSLQIQHQTH----- 700
T +Q KAQ+E LE+ HQ+ EE RLK E++ + + + Q
Sbjct: 2314 TLRQ----KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2369
Query: 701 -RLELQALEE-KARQE-----------------LQEERERMQ--AQQALLLESLRQELSE 739
R++++ L + KAR E LQEE E+M+ A++A L QE +
Sbjct: 2370 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2429
Query: 740 QQAACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGAAGQ 799
+ ++DL A+ RAL + K+ + A +E A +
Sbjct: 2430 LRQLA---EEDL----AQQRALAEKML--------KEKMQAVQE-------------ATR 2461
Query: 800 GSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRAREVETLRQ 859
E L ++ Q+ RRL+ E +Q AQ+L ++ + + T +A+R R++E +
Sbjct: 2462 LKAEAELLQQQKELAQEQARRLQ---EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2518
Query: 860 EHRKEMQAMVADFSSAQAQLQARLAALEAELKDSGEKPGK-GASRPEDLQLIGRLQTRLK 918
R +++ VA+ S AQA+ + + ++ GEK + + E + L+ L+ + +
Sbjct: 2519 AERLKLR--VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ 2576
Query: 919 EREDIIKQLTE 929
+ + ++L E
Sbjct: 2577 QSDHDAERLRE 2587
Score = 128 bits (322), Expect = 2e-29
Identities = 206/918 (22%), Positives = 397/918 (43%), Gaps = 132/918 (14%)
Query: 58 EAEASMEALREAHQEELQNAVAETKA---RLLQEQGCAE----EEALLQRIQALESALEL 110
EAE +++ +EA E L+ +AE +A R L+EQ EE L Q +A +S LE
Sbjct: 1988 EAEIALKE-KEAENERLRR-LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 2045
Query: 111 QKRLTEEAL-------------------AESASCRLETKERELRVEAEHAERVLTLSREM 151
QK L E+ L A + LE + +R AE R S+E
Sbjct: 2046 QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR----SKEQ 2101
Query: 152 LELKADYERRLQHLTSHEATPQGRLPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLS 211
EL+A +R+L Q+S + E + + + L EV+RL+ + ++
Sbjct: 2102 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR--QRKAALEEVERLKAKVEEAR 2159
Query: 212 KDYARKAEELQATYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRK 271
+ R +E + EA ++ +Q + Q+KE +L++ Q ++S L +
Sbjct: 2160 RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD----Q 2215
Query: 272 LEGDLEHRGRKISDLK-------KYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEK 324
L G+ E R + + + A + + ++++ + +LK++ +E ++ + A+ EK
Sbjct: 2216 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-RLKQSAEEQAQARAQAQAAAEK 2274
Query: 325 LAVAKDRMMLQECRGTQQTDAMKTELVSENKVLREENDLEAG-NLHPQQDQSCLKECPCM 383
L + +Q A + + +E LR++ +A H + + L++ +
Sbjct: 2275 LR-----------KEAEQEAARRAQ--AEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2321
Query: 384 KGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEI 443
+ ++ T + ET++ K +E+L+++K + E + + Q+ + L V+ E+
Sbjct: 2322 E--QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ-RSQVEEELFS-VRVQMEEL 2377
Query: 444 KSVRSSVEAERKKLQREVEAQLEEVRKKSEKEIKQLEEEKAALNVKLQNSL-LEVLRLEE 502
+++ +EAE + L + + ++ +++KQ+ EE A L+V Q + L L E+
Sbjct: 2378 SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2437
Query: 503 FIQQNKTRPTGAEESPQELGRQHCSILETQDPCLKLDETSPRGEEYQDKLAAEEGT--SS 560
QQ +E Q + Q + L+ + L + Q +LA E+
Sbjct: 2438 LAQQRALAEKMLKEKMQAV--QEATRLKAEAELL----------QQQKELAQEQARRLQE 2485
Query: 561 DEEERTKVLLKEGSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQ-AQVSQMQQALEQC 619
D+E+ + L +E Q L + + ++LE ++++ KL+ A++S+ Q E
Sbjct: 2486 DKEQMAQQLAEETQGFQRTL------EAERQRQLEMSAEAERLKLRVAEMSRAQARAE-- 2537
Query: 620 TSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLEKARHQ--E 677
ED Q ++ ++ EKL R + TQ+ + LE Q++ E+ R E
Sbjct: 2538 -----EDAQRFRKQAEEIGEKLHRT-ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2591
Query: 678 LKATEERLKKESSHSLQIQHQTHRLELQALE-EKARQELQEERERMQAQQALLLESLRQE 736
L+ +E+L++E+ LQ++ + E+Q ++ E+ QE Q ++ +++ LL+ R
Sbjct: 2592 LEREKEKLQQEAK-LLQLKSE----EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF- 2645
Query: 737 LSEQQAACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGA 796
+ +++A +D A +LR QQ Q + ++A+ E Q + G
Sbjct: 2646 IEQEKAKLEQLFQDEVAKAQQLRE--EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2703
Query: 797 AGQGSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRAREVET 856
+ +LQ ++ R + E +E Q+LR+Q + LEE +A A E
Sbjct: 2704 R-----------RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2752
Query: 857 LRQEHRKEMQAMVADFSSAQAQLQARLAALEAELKDSGEKPGKGASR--------PEDLQ 908
+ A + + L A E E G + A R E+LQ
Sbjct: 2753 TASQ-----VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQ 2807
Query: 909 LIGRLQTRLKE---REDI 923
+ + T + E RED+
Sbjct: 2808 RLAQGHTTVDELARREDV 2825
Score = 122 bits (307), Expect = 1e-27
Identities = 165/741 (22%), Positives = 331/741 (44%), Gaps = 112/741 (15%)
Query: 51 ALNTRQDEAEASMEALRE---AHQEELQNAVAET---KARLLQEQGCAEEEALLQRIQAL 104
A +T + + +A +EA R+ A +EE + AE K+ +E+ + +A L+ ++ L
Sbjct: 2092 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2151
Query: 105 ESALELQKRLTEEALAESA-SCRLETKERELRVEAEHAERVLTLSREMLELKADYERRLQ 163
++ +E +RL E A ESA +L + + R++AE + ++ EL+ ++
Sbjct: 2152 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2211
Query: 164 HLTS--HEATPQGRLPQESPETKSEPG-QGPEMQEVLLEVQRLR--VENQQLSKDYARKA 218
L EA R +E+ E + + + + + + E +RL+ E Q ++ A+ A
Sbjct: 2212 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2271
Query: 219 EELQATYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEH 278
E + E E EA R+A Q+ AL Q Q ++++ K+ + E L+ Q ++E +L
Sbjct: 2272 AE-KLRKEAEQEAARRA--QAEQAALRQKQAADAEMEKHKKFAEQTLR-QKAQVEQELTT 2327
Query: 279 RGRKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECR 338
++ + L E +Q L + EA ++ S+++ E+L + +M
Sbjct: 2328 LRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE-------EELFSVRVQM------ 2374
Query: 339 GTQQTDAMKTELVSENK--VLREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEAS 396
++ +K + +EN+ +LR++++ T++
Sbjct: 2375 --EELSKLKARIEAENRALILRDKDN----------------------------TQRFLQ 2404
Query: 397 AETEYMKQQYEEDLR-KIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERK 455
E E MKQ EE R + Q + L + EDL ++ + K ++ ++A ++
Sbjct: 2405 EEAEKMKQVAEEAARLSVAAQEAARLRQLAE------EDLAQQRALAEKMLKEKMQAVQE 2458
Query: 456 KLQREVEAQLEEVRKK-SEKEIKQLEEEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGA 514
+ + EA+L + +K+ ++++ ++L+E+K + +L R E +Q +
Sbjct: 2459 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL----- 2513
Query: 515 EESPQELGRQHCSILETQDPCLKLDETSPR----GEEYQDKLAAEEGTSSDEEE--RTKV 568
E E R + E + +E + R EE +KL E + ++ +T
Sbjct: 2514 -EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2572
Query: 569 LLKEGSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQ-----------QALE 617
+ ++ SD L+E ++++R +E Q + LQ + +MQ QAL+
Sbjct: 2573 IQRQQSDHD---AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2629
Query: 618 QCTSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLEKARHQE 677
Q + ++ L ++ + E+ KL++ Q+ A QL QR + +E+ R +
Sbjct: 2630 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV----AKAQQLREEQQRQQQQMEQERQRL 2685
Query: 678 LKATEERLKKESSHSLQIQHQTHRLELQALEEKARQE---LQEERERMQAQQALLLESLR 734
+ + EE +++ H + + + ELQ LE++ RQ+ L EE +R++ Q L
Sbjct: 2686 VASMEEARRRQ--HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL------ 2737
Query: 735 QELSEQQAACSGHQKDLEALQ 755
L EQ A H +++ A Q
Sbjct: 2738 --LEEQHRAALAHSEEVTASQ 2756
Score = 108 bits (269), Expect = 3e-23
Identities = 212/1014 (20%), Positives = 408/1014 (40%), Gaps = 182/1014 (17%)
Query: 63 MEALREAHQEE--LQNAVAETKARLLQEQGCAEEEALLQRIQA-LESALELQKRLTEEAL 119
+++L + QEE Q ++E K LQ + C R+ E A E +R+ E+
Sbjct: 1106 LQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQK 1165
Query: 120 AESASCRLETKERELRVEAE---------------HAERVLTLSR--EMLELKADYERRL 162
A++ L L EAE +E LTL + ++ L A Y +L
Sbjct: 1166 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1225
Query: 163 QHLTSHEATPQG-----RLPQES-PETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYAR 216
+ ++ QG R +E E ++ P PE++ +++LR + + +
Sbjct: 1226 KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1285
Query: 217 KAEELQATYE---------RENEAIRQAMQQSVSQALWQWQE-------KESDL------ 254
+EL+ E E + + ++ V+Q L +WQ ++ +L
Sbjct: 1286 LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ 1345
Query: 255 -------------------RKNFQVQ------ESALQAQVRKLEG---DLEHRGRKISDL 286
R+ Q+Q A++ Q+R+ + ++E G K+ +
Sbjct: 1346 LRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEEC 1405
Query: 287 KKYAQKLKERIQDLDVQLKEARQENSELKGTAKK----LGEKLAVAKD------------ 330
+++A++ I+D ++QL + + + AKK G + + +
Sbjct: 1406 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1465
Query: 331 -------------RMMLQECRGTQQTDAMKTELVSENKVLREENDLEAGNLHPQQDQSCL 377
R M +E R +Q A + E ++E + E+ + H Q
Sbjct: 1466 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKAQAE 1524
Query: 378 KECPCM--KGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEE------KKHLKDQLV 429
+E + + ++ ++EA+ + + K+ +E+L++++ +E E + ++
Sbjct: 1525 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1584
Query: 430 KRLEDLVKKHTVEIKSV---RSSVEAERKKLQ---REVEAQLEEVRKKSEKEIKQLEEE- 482
R+E+ ++ +++++ R E E + L+ E EAQ + ++++E+ +Q+++E
Sbjct: 1585 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1644
Query: 483 --KAALNVKLQNSL---LEVLR--------LEEFIQQNKTRPTGAEESPQELGRQHCSIL 529
K V+L + + E R LEE Q + ++ E RQ L
Sbjct: 1645 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1704
Query: 530 ETQDPCLKLDETSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLGSLLKEKTS 589
ET + + S R + +K A E S EE L+E ++ + + +
Sbjct: 1705 ETAQRSAEAELQSKRA-SFAEKTAQLE-RSLQEEHVAVAQLREEAERRAQQQAEAERARE 1762
Query: 590 KIQRLEEDWQ-----SQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQRE 644
+ +R E WQ + + +LQA+ Q++L Q +A KQ + ERE +R
Sbjct: 1763 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQA--------EAEKQKEEAEREARRRG 1814
Query: 645 LQETTQQNHAMKAQLEASHQRALRMLEKARHQELKATEE--RLKKESSHSLQIQHQTHRL 702
E A+ E QR ++ E Q L A +E RL+ E+ Q Q Q
Sbjct: 1815 KAEEQAVRQRELAEQELEKQR--QLAEGTAQQRLAAEQELIRLRAETEQGEQ-QRQLLEE 1871
Query: 703 ELQALEEKA------RQELQEERERMQAQQALLLESLRQELSEQQAACSGHQKDLEALQA 756
EL L+ +A RQEL+ E +++A+ +LL S + E ++ ++ LEA
Sbjct: 1872 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1931
Query: 757 ELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGAAGQ---GSGEGCGLWEENAQ 813
R L + A + + E Q + GE L +
Sbjct: 1932 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL---KTE 1988
Query: 814 LQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRAREVETLRQEHRK-------EMQ 866
+ A++ AE E+ ++ A+ QRR LEE Q AQ ++E + RK +
Sbjct: 1989 AEIALKEKEAENERLRRLAEDEAFQRRRLEE-QAAQHKADIEERLAQLRKASDSELERQK 2047
Query: 867 AMVADFSSAQAQLQARLAALEAELKDSGEKPGKGASRPEDLQL-IGRLQTRLKE 919
+V D + Q++ + AL+A + K A+ +L+L +GR+++ ++
Sbjct: 2048 GLVEDTLRQRRQVEEEILALKASFE-------KAAAGKAELELELGRIRSNAED 2094
Score = 66.6 bits (161), Expect = 1e-10
Identities = 87/381 (22%), Positives = 166/381 (43%), Gaps = 25/381 (6%)
Query: 56 QDEAEASMEALREAHQEEL---QNAVAETKARLLQEQGCAEEEALLQRIQALESALELQK 112
+++ +A EA R + EL Q +A+ +AR LQE + L + Q + LE ++
Sbjct: 2450 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2509
Query: 113 RLTEEALAESASCRLETKERELRVEAEHAERVLTLSREMLELKADYERRLQHLTSHEATP 172
+ E AE+ RL+ + E+ AE R+ E + R + T + T
Sbjct: 2510 QRQLEMSAEAE--RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2567
Query: 173 QGRLPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYARKAEELQATYERENEAI 232
L + ++ + ++E + E++R + + QQ +K K+EE+Q + +
Sbjct: 2568 VQTLEIQRQQSDHD---AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2624
Query: 233 RQAMQQSVSQALWQWQEKESDL-RKNFQVQESALQAQVRKLEGDLEHRGRKISDLKKYAQ 291
QA+QQS EK+S L R+ F QE A Q+ + ++ + + ++ Q
Sbjct: 2625 TQALQQSF------LSEKDSLLQRERFIEQEKAKLEQL--FQDEVAKAQQLREEQQRQQQ 2676
Query: 292 KLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECRGTQQTDAMKTELV 351
++++ Q L ++EAR+ E + ++ E+L + + Q+ R ++ A + + +
Sbjct: 2677 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL-----QQLEQQRRQQEELLAEENQRL 2731
Query: 352 SENKVLREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEASAETEYMKQQYEEDLR 411
E L EE A + S + + G D A AE E+ ++ R
Sbjct: 2732 REQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEH---SFDGLRR 2788
Query: 412 KIKHQTEEEKKHLKDQLVKRL 432
K+ Q +E L + ++RL
Sbjct: 2789 KVSAQRLQEAGILSAEELQRL 2809
Score = 55.5 bits (132), Expect = 3e-07
Identities = 114/568 (20%), Positives = 238/568 (41%), Gaps = 38/568 (6%)
Query: 385 GGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDL-VKKHTVEI 443
GG + + A E Y++ L+ ++ +EE + + + L+D+ ++ E
Sbjct: 1081 GGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRC--QRCISELKDIRLQLEACET 1138
Query: 444 KSVRSSVEAERKKLQREVEAQLEEVRKKSEKEIKQLEEEKAALNVKLQN--SLLEVLRLE 501
++V K+ RE ++ E ++K++ E++ L + A L+ + + +L E
Sbjct: 1139 RTVHRLRLPLDKEPARECAQRIAE-QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAA 1197
Query: 502 EFIQQNKTRPTGAEESPQELGRQHCSILETQDPCLKLDETSP---RGEEYQDKLAAEEGT 558
++ G E + L + L+T ++ + + R E Q K A
Sbjct: 1198 PTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1257
Query: 559 SSDEEERTKVLLKE---GSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQQA 615
+ E E TK LK+ ++ Q P L+++ Q + E Q + + +V + ++
Sbjct: 1258 TLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1317
Query: 616 LEQCTSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLEKARH 675
+ Q ++ L A + E E+L R+L+ + + A L+ + +R ++
Sbjct: 1318 VAQLLERWQAVL-AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ-EQIQAMPL 1375
Query: 676 QELKATEERLKKESSHSLQIQHQTHRLE-LQALEEKARQELQEERERMQAQQALL--LES 732
+ +A E+L++E + +I+ ++E Q ++ +++ ++ +A L + S
Sbjct: 1376 ADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVAS 1435
Query: 733 LRQELSEQQAACSGHQK--DLEALQAELRALGRQQA---SSQCPGDSKDHIIATEERGGP 787
++ Q + S Q+ DL +EL L Q S ++ +A ++R
Sbjct: 1436 PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE 1495
Query: 788 GQAGSPPGAAGQGSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQ 847
+ + AA + + L E +AQ + R E++Q QE R++ + Q+
Sbjct: 1496 RERLAEVEAALEKQRQ---LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1552
Query: 848 AQRAREVETLRQEHRKEMQAM-----VADFSSAQAQLQARLAALEAELKDSGEKPGKGAS 902
E++ LRQ E+QA A+ S + + + R+ L+ E + +G
Sbjct: 1553 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG-- 1610
Query: 903 RPEDLQLIGRLQTRLKEREDIIKQLTEE 930
+LQ L+ R +E E +Q EE
Sbjct: 1611 ---ELQ---ALRARAEEAEAQKRQAQEE 1632
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 142 bits (358), Expect = 2e-33
Identities = 228/975 (23%), Positives = 427/975 (43%), Gaps = 117/975 (12%)
Query: 55 RQDEAEASMEALREAHQEEL----QNAVAETKARLLQEQGC------AEEEALLQRIQ-- 102
R++EA + + + QEEL Q++ AE +A+ Q + EEE + R+Q
Sbjct: 1381 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1440
Query: 103 -------ALESALELQKRLTEEALAESASCRLETKERELRVEAEHAERVLTLSREMLELK 155
E L+ + EEA A+ + E + +V+ E + +K
Sbjct: 1441 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1500
Query: 156 ADYERRLQHLTSHEATPQGRLPQESPETK---SEPGQGPEMQEVLLEVQR-LRVENQQLS 211
A+ E + + +A + RL E E + +E + ++Q L QR E Q
Sbjct: 1501 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1560
Query: 212 KDYARKAEELQATYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRK 271
+A K +L+ + + E+ A+ Q +++ +A Q Q A +A+ +
Sbjct: 1561 ASFAEKTAQLERSLQEEHVAVAQLREEAERRA---------------QQQAEAERAR-EE 1604
Query: 272 LEGDLEHRGRKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLG--EKLAVAK 329
E +LE K ++ + + +E Q + EA ++ E + A++ G E+ AV +
Sbjct: 1605 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1664
Query: 330 DRMMLQECRGTQQ--TDAMKTELVSENKVLREENDLEAGNLHPQQDQSCLKECPCMKGGT 387
+ QE +Q + L +E +++R + E G QQ Q +E ++
Sbjct: 1665 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE---QQRQLLEEELARLQREA 1721
Query: 388 DMQTKKEASAETEYMKQQYE-EDLRKIKHQTEEEKKHLKDQLVKRLE-DLVKKHTVEIKS 445
T+K E E K + E E L K + EEE + ++ +RLE + + + ++
Sbjct: 1722 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1781
Query: 446 VRSSVEAERKKLQREVEAQLEEVRKKSEKEIKQLEEEKAALNVKLQNSLLEVLRLEEFIQ 505
R AE K QR++ A+ + R+++E E + L E+ AA+ + + L+E
Sbjct: 1782 ARLRALAEEAKRQRQL-AEEDAARQRAEAE-RVLAEKLAAIGEATRLKTEAEIALKEKEA 1839
Query: 506 QNKTRPTGAEESPQELGRQHCSILETQDPCLKLDETSPRGEEYQDKLAAEEGTSSDEEER 565
+N+ AE+ + R LE Q K D +++LA S E ER
Sbjct: 1840 ENERLRRLAEDEAFQRRR-----LEEQAAQHKAD--------IEERLAQLRKASDSELER 1886
Query: 566 TKVLLKEGSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQ-QALEQCTSNYR 624
K L+++ + ++E+ ++ E + KA+L+ ++ +++ A + S +
Sbjct: 1887 QKGLVEDTLRQR----RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ 1942
Query: 625 EDLQALKQLS-DLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLE--KARHQELKAT 681
+L+A +Q E E+ +RE +E Q++ A + + + AL +E KA+ +E +
Sbjct: 1943 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRL 2002
Query: 682 EERLKKESSHSLQIQHQTHRLELQALEEKAR----QELQEERERMQAQQALLLESLRQEL 737
ER ++ES+ LQ+ + + LQA EEKA Q+ ++E ++ Q+ +L+ LR E
Sbjct: 2003 RERAEQESARQLQLAQEAAQKRLQA-EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2061
Query: 738 SEQQAACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGAA 797
+ A EA +A ++A R+ A S+ + + + + E + A
Sbjct: 2062 EAARRAAE------EAEEARVQA-EREAAQSRRQVEEAERLKQSAEEQAQAR------AQ 2108
Query: 798 GQGSGEGCGLWEENAQLQDAVRRLRAE---VEQHQQEAQKLRDQRRFLEET--QQAQRAR 852
Q + E E Q+A RR +AE + Q Q ++ ++F E+T Q+AQ +
Sbjct: 2109 AQAAAEKLRKEAE----QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2164
Query: 853 EVETLR-----QEHRK-----EMQAMVADFSSA---QAQLQARLAALEAELKDSGEKPGK 899
E+ TLR +H+K E+Q + A+ + A ++Q++ L ++ ++++ + K
Sbjct: 2165 ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL--K 2222
Query: 900 GASRPEDLQLIGR----LQTRLKEREDIIKQLTEERRFHYAAFPSAMSHRNRSFSFNPHP 955
E+ LI R Q L+E + +KQ+ EE A A R +
Sbjct: 2223 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2282
Query: 956 GYLTPSMKKKKVEDV 970
L M K+K++ V
Sbjct: 2283 RALAEKMLKEKMQAV 2297
Score = 138 bits (348), Expect = 2e-32
Identities = 222/971 (22%), Positives = 413/971 (42%), Gaps = 141/971 (14%)
Query: 47 KVIYALNTRQDEAEASMEALREAHQEELQNAVAETKARLLQEQGCAEEEALLQRIQALES 106
+ + AL + +AE + LR+A E + + + L Q AE E +R E
Sbjct: 1511 RALQALEELRLQAEEAERRLRQAEVERAR----QVQVALETAQRSAEAELQSKRASFAEK 1566
Query: 107 ALELQKRLTEEALAESASCRLETKER-ELRVEAEHAERVLTLSREMLELKADYERRLQHL 165
+L++ L EE +A A R E + R + + EAE A E +LKA+ RL+ L
Sbjct: 1567 TAQLERSLQEEHVA-VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR-L 1624
Query: 166 TSHEATPQGRLPQESPETKSEPGQGPEMQEVLLEVQRLR---VENQQLSKDYARKAEELQ 222
+ E Q L Q E + E + + E Q +R + Q+L K Q
Sbjct: 1625 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1684
Query: 223 ATYERENEAIR--------QAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEG 274
E E IR + +Q + + L + Q + + + Q E+ L ++E
Sbjct: 1685 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1744
Query: 275 DLEHRGRKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAK----- 329
L + R + + ++K K+R++ + +E +E + L+ A++ + +A+
Sbjct: 1745 LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR 1804
Query: 330 -----DRMMLQECRGTQQTDAMKTEL-------VSENKVLREENDLEAGNLHPQQDQSCL 377
+R++ ++ + +KTE +EN+ LR + EA ++Q+
Sbjct: 1805 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ 1864
Query: 378 KECPCMKGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVK------- 430
+ + Q +K + +E E K E+ LR+ + Q EEE LK K
Sbjct: 1865 HKADIEE--RLAQLRKASDSELERQKGLVEDTLRQ-RRQVEEEILALKASFEKAAAGKAE 1921
Query: 431 ----------RLEDLVK-KHTVEIKSVRS-SVEAERKKLQREVEAQLEEVRKKSEKEIKQ 478
ED ++ K E+++ R + AE ++ +RE E E V+K E +
Sbjct: 1922 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE---ERVQKSLAAEEEA 1978
Query: 479 LEEEKAALN--VKLQNSLLEVLRLEEFIQQNKTRPTG-AEESPQE--LGRQHCSILETQD 533
+ KAAL +L+ + E RL E +Q R A+E+ Q+ + Q
Sbjct: 1979 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2038
Query: 534 PCLKLDETSPRGEEYQDKLAAEEGT---SSDEEERTKVLLKEGSDPQPPLGSLLKEKTSK 590
+L +T + + D+L E +++E E +V ++ + E+ +
Sbjct: 2039 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV----QAEREAAQSRRQVEEAER 2094
Query: 591 IQRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQAL---KQLSDLEREKLQRELQE 647
+++ E+ +A+ QA ++++ EQ + + QA KQ +D E EK ++ ++
Sbjct: 2095 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2154
Query: 648 TTQQNHAMKAQLEASHQRALRMLEKARHQELKATEE--RLKKESSHSLQIQHQTH----- 700
T +Q KAQ+E LE+ HQ+ EE RLK E++ + + + Q
Sbjct: 2155 TLRQ----KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2210
Query: 701 -RLELQALEE-KARQE-----------------LQEERERMQ--AQQALLLESLRQELSE 739
R++++ L + KAR E LQEE E+M+ A++A L QE +
Sbjct: 2211 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2270
Query: 740 QQAACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGAAGQ 799
+ ++DL A+ RAL + K+ + A +E A +
Sbjct: 2271 LRQLA---EEDL----AQQRALAEKML--------KEKMQAVQE-------------ATR 2302
Query: 800 GSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRAREVETLRQ 859
E L ++ Q+ RRL+ E +Q AQ+L ++ + + T +A+R R++E +
Sbjct: 2303 LKAEAELLQQQKELAQEQARRLQ---EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2359
Query: 860 EHRKEMQAMVADFSSAQAQLQARLAALEAELKDSGEKPGK-GASRPEDLQLIGRLQTRLK 918
R +++ VA+ S AQA+ + + ++ GEK + + E + L+ L+ + +
Sbjct: 2360 AERLKLR--VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ 2417
Query: 919 EREDIIKQLTE 929
+ + ++L E
Sbjct: 2418 QSDHDAERLRE 2428
Score = 128 bits (322), Expect = 2e-29
Identities = 206/918 (22%), Positives = 397/918 (43%), Gaps = 132/918 (14%)
Query: 58 EAEASMEALREAHQEELQNAVAETKA---RLLQEQGCAE----EEALLQRIQALESALEL 110
EAE +++ +EA E L+ +AE +A R L+EQ EE L Q +A +S LE
Sbjct: 1829 EAEIALKE-KEAENERLRR-LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1886
Query: 111 QKRLTEEAL-------------------AESASCRLETKERELRVEAEHAERVLTLSREM 151
QK L E+ L A + LE + +R AE R S+E
Sbjct: 1887 QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR----SKEQ 1942
Query: 152 LELKADYERRLQHLTSHEATPQGRLPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLS 211
EL+A +R+L Q+S + E + + + L EV+RL+ + ++
Sbjct: 1943 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR--QRKAALEEVERLKAKVEEAR 2000
Query: 212 KDYARKAEELQATYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRK 271
+ R +E + EA ++ +Q + Q+KE +L++ Q ++S L +
Sbjct: 2001 RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD----Q 2056
Query: 272 LEGDLEHRGRKISDLK-------KYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEK 324
L G+ E R + + + A + + ++++ + +LK++ +E ++ + A+ EK
Sbjct: 2057 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-RLKQSAEEQAQARAQAQAAAEK 2115
Query: 325 LAVAKDRMMLQECRGTQQTDAMKTELVSENKVLREENDLEAG-NLHPQQDQSCLKECPCM 383
L + +Q A + + +E LR++ +A H + + L++ +
Sbjct: 2116 LR-----------KEAEQEAARRAQ--AEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2162
Query: 384 KGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEI 443
+ ++ T + ET++ K +E+L+++K + E + + Q+ + L V+ E+
Sbjct: 2163 E--QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ-RSQVEEELFS-VRVQMEEL 2218
Query: 444 KSVRSSVEAERKKLQREVEAQLEEVRKKSEKEIKQLEEEKAALNVKLQNSL-LEVLRLEE 502
+++ +EAE + L + + ++ +++KQ+ EE A L+V Q + L L E+
Sbjct: 2219 SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2278
Query: 503 FIQQNKTRPTGAEESPQELGRQHCSILETQDPCLKLDETSPRGEEYQDKLAAEEGT--SS 560
QQ +E Q + Q + L+ + L + Q +LA E+
Sbjct: 2279 LAQQRALAEKMLKEKMQAV--QEATRLKAEAELL----------QQQKELAQEQARRLQE 2326
Query: 561 DEEERTKVLLKEGSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQ-AQVSQMQQALEQC 619
D+E+ + L +E Q L + + ++LE ++++ KL+ A++S+ Q E
Sbjct: 2327 DKEQMAQQLAEETQGFQRTL------EAERQRQLEMSAEAERLKLRVAEMSRAQARAE-- 2378
Query: 620 TSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLEKARHQ--E 677
ED Q ++ ++ EKL R + TQ+ + LE Q++ E+ R E
Sbjct: 2379 -----EDAQRFRKQAEEIGEKLHRT-ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2432
Query: 678 LKATEERLKKESSHSLQIQHQTHRLELQALE-EKARQELQEERERMQAQQALLLESLRQE 736
L+ +E+L++E+ LQ++ + E+Q ++ E+ QE Q ++ +++ LL+ R
Sbjct: 2433 LEREKEKLQQEAK-LLQLKSE----EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF- 2486
Query: 737 LSEQQAACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGA 796
+ +++A +D A +LR QQ Q + ++A+ E Q + G
Sbjct: 2487 IEQEKAKLEQLFQDEVAKAQQLRE--EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2544
Query: 797 AGQGSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRAREVET 856
+ +LQ ++ R + E +E Q+LR+Q + LEE +A A E
Sbjct: 2545 R-----------RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2593
Query: 857 LRQEHRKEMQAMVADFSSAQAQLQARLAALEAELKDSGEKPGKGASR--------PEDLQ 908
+ A + + L A E E G + A R E+LQ
Sbjct: 2594 TASQ-----VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQ 2648
Query: 909 LIGRLQTRLKE---REDI 923
+ + T + E RED+
Sbjct: 2649 RLAQGHTTVDELARREDV 2666
Score = 122 bits (307), Expect = 1e-27
Identities = 165/741 (22%), Positives = 331/741 (44%), Gaps = 112/741 (15%)
Query: 51 ALNTRQDEAEASMEALRE---AHQEELQNAVAET---KARLLQEQGCAEEEALLQRIQAL 104
A +T + + +A +EA R+ A +EE + AE K+ +E+ + +A L+ ++ L
Sbjct: 1933 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 1992
Query: 105 ESALELQKRLTEEALAESA-SCRLETKERELRVEAEHAERVLTLSREMLELKADYERRLQ 163
++ +E +RL E A ESA +L + + R++AE + ++ EL+ ++
Sbjct: 1993 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2052
Query: 164 HLTS--HEATPQGRLPQESPETKSEPG-QGPEMQEVLLEVQRLR--VENQQLSKDYARKA 218
L EA R +E+ E + + + + + + E +RL+ E Q ++ A+ A
Sbjct: 2053 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2112
Query: 219 EELQATYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEH 278
E + E E EA R+A Q+ AL Q Q ++++ K+ + E L+ Q ++E +L
Sbjct: 2113 AE-KLRKEAEQEAARRA--QAEQAALRQKQAADAEMEKHKKFAEQTLR-QKAQVEQELTT 2168
Query: 279 RGRKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECR 338
++ + L E +Q L + EA ++ S+++ E+L + +M
Sbjct: 2169 LRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE-------EELFSVRVQM------ 2215
Query: 339 GTQQTDAMKTELVSENK--VLREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEAS 396
++ +K + +EN+ +LR++++ T++
Sbjct: 2216 --EELSKLKARIEAENRALILRDKDN----------------------------TQRFLQ 2245
Query: 397 AETEYMKQQYEEDLR-KIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERK 455
E E MKQ EE R + Q + L + EDL ++ + K ++ ++A ++
Sbjct: 2246 EEAEKMKQVAEEAARLSVAAQEAARLRQLAE------EDLAQQRALAEKMLKEKMQAVQE 2299
Query: 456 KLQREVEAQLEEVRKK-SEKEIKQLEEEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGA 514
+ + EA+L + +K+ ++++ ++L+E+K + +L R E +Q +
Sbjct: 2300 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL----- 2354
Query: 515 EESPQELGRQHCSILETQDPCLKLDETSPR----GEEYQDKLAAEEGTSSDEEE--RTKV 568
E E R + E + +E + R EE +KL E + ++ +T
Sbjct: 2355 -EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2413
Query: 569 LLKEGSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQ-----------QALE 617
+ ++ SD L+E ++++R +E Q + LQ + +MQ QAL+
Sbjct: 2414 IQRQQSDHD---AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2470
Query: 618 QCTSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLEKARHQE 677
Q + ++ L ++ + E+ KL++ Q+ A QL QR + +E+ R +
Sbjct: 2471 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV----AKAQQLREEQQRQQQQMEQERQRL 2526
Query: 678 LKATEERLKKESSHSLQIQHQTHRLELQALEEKARQE---LQEERERMQAQQALLLESLR 734
+ + EE +++ H + + + ELQ LE++ RQ+ L EE +R++ Q L
Sbjct: 2527 VASMEEARRRQ--HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL------ 2578
Query: 735 QELSEQQAACSGHQKDLEALQ 755
L EQ A H +++ A Q
Sbjct: 2579 --LEEQHRAALAHSEEVTASQ 2597
Score = 108 bits (269), Expect = 3e-23
Identities = 212/1014 (20%), Positives = 408/1014 (40%), Gaps = 182/1014 (17%)
Query: 63 MEALREAHQEE--LQNAVAETKARLLQEQGCAEEEALLQRIQA-LESALELQKRLTEEAL 119
+++L + QEE Q ++E K LQ + C R+ E A E +R+ E+
Sbjct: 947 LQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQK 1006
Query: 120 AESASCRLETKERELRVEAE---------------HAERVLTLSR--EMLELKADYERRL 162
A++ L L EAE +E LTL + ++ L A Y +L
Sbjct: 1007 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1066
Query: 163 QHLTSHEATPQG-----RLPQES-PETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYAR 216
+ ++ QG R +E E ++ P PE++ +++LR + + +
Sbjct: 1067 KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1126
Query: 217 KAEELQATYE---------RENEAIRQAMQQSVSQALWQWQE-------KESDL------ 254
+EL+ E E + + ++ V+Q L +WQ ++ +L
Sbjct: 1127 LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ 1186
Query: 255 -------------------RKNFQVQ------ESALQAQVRKLEG---DLEHRGRKISDL 286
R+ Q+Q A++ Q+R+ + ++E G K+ +
Sbjct: 1187 LRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEEC 1246
Query: 287 KKYAQKLKERIQDLDVQLKEARQENSELKGTAKK----LGEKLAVAKD------------ 330
+++A++ I+D ++QL + + + AKK G + + +
Sbjct: 1247 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1306
Query: 331 -------------RMMLQECRGTQQTDAMKTELVSENKVLREENDLEAGNLHPQQDQSCL 377
R M +E R +Q A + E ++E + E+ + H Q
Sbjct: 1307 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKAQAE 1365
Query: 378 KECPCM--KGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEE------KKHLKDQLV 429
+E + + ++ ++EA+ + + K+ +E+L++++ +E E + ++
Sbjct: 1366 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1425
Query: 430 KRLEDLVKKHTVEIKSV---RSSVEAERKKLQ---REVEAQLEEVRKKSEKEIKQLEEE- 482
R+E+ ++ +++++ R E E + L+ E EAQ + ++++E+ +Q+++E
Sbjct: 1426 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1485
Query: 483 --KAALNVKLQNSL---LEVLR--------LEEFIQQNKTRPTGAEESPQELGRQHCSIL 529
K V+L + + E R LEE Q + ++ E RQ L
Sbjct: 1486 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1545
Query: 530 ETQDPCLKLDETSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLGSLLKEKTS 589
ET + + S R + +K A E S EE L+E ++ + + +
Sbjct: 1546 ETAQRSAEAELQSKRA-SFAEKTAQLE-RSLQEEHVAVAQLREEAERRAQQQAEAERARE 1603
Query: 590 KIQRLEEDWQ-----SQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQRE 644
+ +R E WQ + + +LQA+ Q++L Q +A KQ + ERE +R
Sbjct: 1604 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQA--------EAEKQKEEAEREARRRG 1655
Query: 645 LQETTQQNHAMKAQLEASHQRALRMLEKARHQELKATEE--RLKKESSHSLQIQHQTHRL 702
E A+ E QR ++ E Q L A +E RL+ E+ Q Q Q
Sbjct: 1656 KAEEQAVRQRELAEQELEKQR--QLAEGTAQQRLAAEQELIRLRAETEQGEQ-QRQLLEE 1712
Query: 703 ELQALEEKA------RQELQEERERMQAQQALLLESLRQELSEQQAACSGHQKDLEALQA 756
EL L+ +A RQEL+ E +++A+ +LL S + E ++ ++ LEA
Sbjct: 1713 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1772
Query: 757 ELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGAAGQ---GSGEGCGLWEENAQ 813
R L + A + + E Q + GE L +
Sbjct: 1773 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL---KTE 1829
Query: 814 LQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRAREVETLRQEHRK-------EMQ 866
+ A++ AE E+ ++ A+ QRR LEE Q AQ ++E + RK +
Sbjct: 1830 AEIALKEKEAENERLRRLAEDEAFQRRRLEE-QAAQHKADIEERLAQLRKASDSELERQK 1888
Query: 867 AMVADFSSAQAQLQARLAALEAELKDSGEKPGKGASRPEDLQL-IGRLQTRLKE 919
+V D + Q++ + AL+A + K A+ +L+L +GR+++ ++
Sbjct: 1889 GLVEDTLRQRRQVEEEILALKASFE-------KAAAGKAELELELGRIRSNAED 1935
Score = 66.6 bits (161), Expect = 1e-10
Identities = 87/381 (22%), Positives = 166/381 (43%), Gaps = 25/381 (6%)
Query: 56 QDEAEASMEALREAHQEEL---QNAVAETKARLLQEQGCAEEEALLQRIQALESALELQK 112
+++ +A EA R + EL Q +A+ +AR LQE + L + Q + LE ++
Sbjct: 2291 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2350
Query: 113 RLTEEALAESASCRLETKERELRVEAEHAERVLTLSREMLELKADYERRLQHLTSHEATP 172
+ E AE+ RL+ + E+ AE R+ E + R + T + T
Sbjct: 2351 QRQLEMSAEAE--RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2408
Query: 173 QGRLPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYARKAEELQATYERENEAI 232
L + ++ + ++E + E++R + + QQ +K K+EE+Q + +
Sbjct: 2409 VQTLEIQRQQSDHD---AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2465
Query: 233 RQAMQQSVSQALWQWQEKESDL-RKNFQVQESALQAQVRKLEGDLEHRGRKISDLKKYAQ 291
QA+QQS EK+S L R+ F QE A Q+ + ++ + + ++ Q
Sbjct: 2466 TQALQQSF------LSEKDSLLQRERFIEQEKAKLEQL--FQDEVAKAQQLREEQQRQQQ 2517
Query: 292 KLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECRGTQQTDAMKTELV 351
++++ Q L ++EAR+ E + ++ E+L + + Q+ R ++ A + + +
Sbjct: 2518 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL-----QQLEQQRRQQEELLAEENQRL 2572
Query: 352 SENKVLREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEASAETEYMKQQYEEDLR 411
E L EE A + S + + G D A AE E+ ++ R
Sbjct: 2573 REQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEH---SFDGLRR 2629
Query: 412 KIKHQTEEEKKHLKDQLVKRL 432
K+ Q +E L + ++RL
Sbjct: 2630 KVSAQRLQEAGILSAEELQRL 2650
Score = 55.5 bits (132), Expect = 3e-07
Identities = 114/568 (20%), Positives = 238/568 (41%), Gaps = 38/568 (6%)
Query: 385 GGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDL-VKKHTVEI 443
GG + + A E Y++ L+ ++ +EE + + + L+D+ ++ E
Sbjct: 922 GGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRC--QRCISELKDIRLQLEACET 979
Query: 444 KSVRSSVEAERKKLQREVEAQLEEVRKKSEKEIKQLEEEKAALNVKLQN--SLLEVLRLE 501
++V K+ RE ++ E ++K++ E++ L + A L+ + + +L E
Sbjct: 980 RTVHRLRLPLDKEPARECAQRIAE-QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAA 1038
Query: 502 EFIQQNKTRPTGAEESPQELGRQHCSILETQDPCLKLDETSP---RGEEYQDKLAAEEGT 558
++ G E + L + L+T ++ + + R E Q K A
Sbjct: 1039 PTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1098
Query: 559 SSDEEERTKVLLKE---GSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQQA 615
+ E E TK LK+ ++ Q P L+++ Q + E Q + + +V + ++
Sbjct: 1099 TLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1158
Query: 616 LEQCTSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLEKARH 675
+ Q ++ L A + E E+L R+L+ + + A L+ + +R ++
Sbjct: 1159 VAQLLERWQAVL-AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ-EQIQAMPL 1216
Query: 676 QELKATEERLKKESSHSLQIQHQTHRLE-LQALEEKARQELQEERERMQAQQALL--LES 732
+ +A E+L++E + +I+ ++E Q ++ +++ ++ +A L + S
Sbjct: 1217 ADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVAS 1276
Query: 733 LRQELSEQQAACSGHQK--DLEALQAELRALGRQQA---SSQCPGDSKDHIIATEERGGP 787
++ Q + S Q+ DL +EL L Q S ++ +A ++R
Sbjct: 1277 PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE 1336
Query: 788 GQAGSPPGAAGQGSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQ 847
+ + AA + + L E +AQ + R E++Q QE R++ + Q+
Sbjct: 1337 RERLAEVEAALEKQRQ---LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1393
Query: 848 AQRAREVETLRQEHRKEMQAM-----VADFSSAQAQLQARLAALEAELKDSGEKPGKGAS 902
E++ LRQ E+QA A+ S + + + R+ L+ E + +G
Sbjct: 1394 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG-- 1451
Query: 903 RPEDLQLIGRLQTRLKEREDIIKQLTEE 930
+LQ L+ R +E E +Q EE
Sbjct: 1452 ---ELQ---ALRARAEEAEAQKRQAQEE 1473
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 142 bits (358), Expect = 2e-33
Identities = 228/975 (23%), Positives = 427/975 (43%), Gaps = 117/975 (12%)
Query: 55 RQDEAEASMEALREAHQEEL----QNAVAETKARLLQEQGC------AEEEALLQRIQ-- 102
R++EA + + + QEEL Q++ AE +A+ Q + EEE + R+Q
Sbjct: 1389 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1448
Query: 103 -------ALESALELQKRLTEEALAESASCRLETKERELRVEAEHAERVLTLSREMLELK 155
E L+ + EEA A+ + E + +V+ E + +K
Sbjct: 1449 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1508
Query: 156 ADYERRLQHLTSHEATPQGRLPQESPETK---SEPGQGPEMQEVLLEVQR-LRVENQQLS 211
A+ E + + +A + RL E E + +E + ++Q L QR E Q
Sbjct: 1509 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1568
Query: 212 KDYARKAEELQATYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRK 271
+A K +L+ + + E+ A+ Q +++ +A Q Q A +A+ +
Sbjct: 1569 ASFAEKTAQLERSLQEEHVAVAQLREEAERRA---------------QQQAEAERAR-EE 1612
Query: 272 LEGDLEHRGRKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLG--EKLAVAK 329
E +LE K ++ + + +E Q + EA ++ E + A++ G E+ AV +
Sbjct: 1613 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1672
Query: 330 DRMMLQECRGTQQ--TDAMKTELVSENKVLREENDLEAGNLHPQQDQSCLKECPCMKGGT 387
+ QE +Q + L +E +++R + E G QQ Q +E ++
Sbjct: 1673 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE---QQRQLLEEELARLQREA 1729
Query: 388 DMQTKKEASAETEYMKQQYE-EDLRKIKHQTEEEKKHLKDQLVKRLE-DLVKKHTVEIKS 445
T+K E E K + E E L K + EEE + ++ +RLE + + + ++
Sbjct: 1730 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1789
Query: 446 VRSSVEAERKKLQREVEAQLEEVRKKSEKEIKQLEEEKAALNVKLQNSLLEVLRLEEFIQ 505
R AE K QR++ A+ + R+++E E + L E+ AA+ + + L+E
Sbjct: 1790 ARLRALAEEAKRQRQL-AEEDAARQRAEAE-RVLAEKLAAIGEATRLKTEAEIALKEKEA 1847
Query: 506 QNKTRPTGAEESPQELGRQHCSILETQDPCLKLDETSPRGEEYQDKLAAEEGTSSDEEER 565
+N+ AE+ + R LE Q K D +++LA S E ER
Sbjct: 1848 ENERLRRLAEDEAFQRRR-----LEEQAAQHKAD--------IEERLAQLRKASDSELER 1894
Query: 566 TKVLLKEGSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQ-QALEQCTSNYR 624
K L+++ + ++E+ ++ E + KA+L+ ++ +++ A + S +
Sbjct: 1895 QKGLVEDTLRQR----RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ 1950
Query: 625 EDLQALKQLS-DLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLE--KARHQELKAT 681
+L+A +Q E E+ +RE +E Q++ A + + + AL +E KA+ +E +
Sbjct: 1951 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRL 2010
Query: 682 EERLKKESSHSLQIQHQTHRLELQALEEKAR----QELQEERERMQAQQALLLESLRQEL 737
ER ++ES+ LQ+ + + LQA EEKA Q+ ++E ++ Q+ +L+ LR E
Sbjct: 2011 RERAEQESARQLQLAQEAAQKRLQA-EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2069
Query: 738 SEQQAACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGAA 797
+ A EA +A ++A R+ A S+ + + + + E + A
Sbjct: 2070 EAARRAAE------EAEEARVQA-EREAAQSRRQVEEAERLKQSAEEQAQAR------AQ 2116
Query: 798 GQGSGEGCGLWEENAQLQDAVRRLRAE---VEQHQQEAQKLRDQRRFLEET--QQAQRAR 852
Q + E E Q+A RR +AE + Q Q ++ ++F E+T Q+AQ +
Sbjct: 2117 AQAAAEKLRKEAE----QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2172
Query: 853 EVETLR-----QEHRK-----EMQAMVADFSSA---QAQLQARLAALEAELKDSGEKPGK 899
E+ TLR +H+K E+Q + A+ + A ++Q++ L ++ ++++ + K
Sbjct: 2173 ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL--K 2230
Query: 900 GASRPEDLQLIGR----LQTRLKEREDIIKQLTEERRFHYAAFPSAMSHRNRSFSFNPHP 955
E+ LI R Q L+E + +KQ+ EE A A R +
Sbjct: 2231 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2290
Query: 956 GYLTPSMKKKKVEDV 970
L M K+K++ V
Sbjct: 2291 RALAEKMLKEKMQAV 2305
Score = 138 bits (348), Expect = 2e-32
Identities = 222/971 (22%), Positives = 413/971 (42%), Gaps = 141/971 (14%)
Query: 47 KVIYALNTRQDEAEASMEALREAHQEELQNAVAETKARLLQEQGCAEEEALLQRIQALES 106
+ + AL + +AE + LR+A E + + + L Q AE E +R E
Sbjct: 1519 RALQALEELRLQAEEAERRLRQAEVERAR----QVQVALETAQRSAEAELQSKRASFAEK 1574
Query: 107 ALELQKRLTEEALAESASCRLETKER-ELRVEAEHAERVLTLSREMLELKADYERRLQHL 165
+L++ L EE +A A R E + R + + EAE A E +LKA+ RL+ L
Sbjct: 1575 TAQLERSLQEEHVA-VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR-L 1632
Query: 166 TSHEATPQGRLPQESPETKSEPGQGPEMQEVLLEVQRLR---VENQQLSKDYARKAEELQ 222
+ E Q L Q E + E + + E Q +R + Q+L K Q
Sbjct: 1633 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1692
Query: 223 ATYERENEAIR--------QAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEG 274
E E IR + +Q + + L + Q + + + Q E+ L ++E
Sbjct: 1693 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1752
Query: 275 DLEHRGRKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAK----- 329
L + R + + ++K K+R++ + +E +E + L+ A++ + +A+
Sbjct: 1753 LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR 1812
Query: 330 -----DRMMLQECRGTQQTDAMKTEL-------VSENKVLREENDLEAGNLHPQQDQSCL 377
+R++ ++ + +KTE +EN+ LR + EA ++Q+
Sbjct: 1813 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ 1872
Query: 378 KECPCMKGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVK------- 430
+ + Q +K + +E E K E+ LR+ + Q EEE LK K
Sbjct: 1873 HKADIEE--RLAQLRKASDSELERQKGLVEDTLRQ-RRQVEEEILALKASFEKAAAGKAE 1929
Query: 431 ----------RLEDLVK-KHTVEIKSVRS-SVEAERKKLQREVEAQLEEVRKKSEKEIKQ 478
ED ++ K E+++ R + AE ++ +RE E E V+K E +
Sbjct: 1930 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE---ERVQKSLAAEEEA 1986
Query: 479 LEEEKAALN--VKLQNSLLEVLRLEEFIQQNKTRPTG-AEESPQE--LGRQHCSILETQD 533
+ KAAL +L+ + E RL E +Q R A+E+ Q+ + Q
Sbjct: 1987 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2046
Query: 534 PCLKLDETSPRGEEYQDKLAAEEGT---SSDEEERTKVLLKEGSDPQPPLGSLLKEKTSK 590
+L +T + + D+L E +++E E +V ++ + E+ +
Sbjct: 2047 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV----QAEREAAQSRRQVEEAER 2102
Query: 591 IQRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQAL---KQLSDLEREKLQRELQE 647
+++ E+ +A+ QA ++++ EQ + + QA KQ +D E EK ++ ++
Sbjct: 2103 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2162
Query: 648 TTQQNHAMKAQLEASHQRALRMLEKARHQELKATEE--RLKKESSHSLQIQHQTH----- 700
T +Q KAQ+E LE+ HQ+ EE RLK E++ + + + Q
Sbjct: 2163 TLRQ----KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2218
Query: 701 -RLELQALEE-KARQE-----------------LQEERERMQ--AQQALLLESLRQELSE 739
R++++ L + KAR E LQEE E+M+ A++A L QE +
Sbjct: 2219 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2278
Query: 740 QQAACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGAAGQ 799
+ ++DL A+ RAL + K+ + A +E A +
Sbjct: 2279 LRQLA---EEDL----AQQRALAEKML--------KEKMQAVQE-------------ATR 2310
Query: 800 GSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRAREVETLRQ 859
E L ++ Q+ RRL+ E +Q AQ+L ++ + + T +A+R R++E +
Sbjct: 2311 LKAEAELLQQQKELAQEQARRLQ---EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2367
Query: 860 EHRKEMQAMVADFSSAQAQLQARLAALEAELKDSGEKPGK-GASRPEDLQLIGRLQTRLK 918
R +++ VA+ S AQA+ + + ++ GEK + + E + L+ L+ + +
Sbjct: 2368 AERLKLR--VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ 2425
Query: 919 EREDIIKQLTE 929
+ + ++L E
Sbjct: 2426 QSDHDAERLRE 2436
Score = 128 bits (322), Expect = 2e-29
Identities = 206/918 (22%), Positives = 397/918 (43%), Gaps = 132/918 (14%)
Query: 58 EAEASMEALREAHQEELQNAVAETKA---RLLQEQGCAE----EEALLQRIQALESALEL 110
EAE +++ +EA E L+ +AE +A R L+EQ EE L Q +A +S LE
Sbjct: 1837 EAEIALKE-KEAENERLRR-LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1894
Query: 111 QKRLTEEAL-------------------AESASCRLETKERELRVEAEHAERVLTLSREM 151
QK L E+ L A + LE + +R AE R S+E
Sbjct: 1895 QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR----SKEQ 1950
Query: 152 LELKADYERRLQHLTSHEATPQGRLPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLS 211
EL+A +R+L Q+S + E + + + L EV+RL+ + ++
Sbjct: 1951 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR--QRKAALEEVERLKAKVEEAR 2008
Query: 212 KDYARKAEELQATYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRK 271
+ R +E + EA ++ +Q + Q+KE +L++ Q ++S L +
Sbjct: 2009 RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD----Q 2064
Query: 272 LEGDLEHRGRKISDLK-------KYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEK 324
L G+ E R + + + A + + ++++ + +LK++ +E ++ + A+ EK
Sbjct: 2065 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-RLKQSAEEQAQARAQAQAAAEK 2123
Query: 325 LAVAKDRMMLQECRGTQQTDAMKTELVSENKVLREENDLEAG-NLHPQQDQSCLKECPCM 383
L + +Q A + + +E LR++ +A H + + L++ +
Sbjct: 2124 LR-----------KEAEQEAARRAQ--AEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2170
Query: 384 KGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEI 443
+ ++ T + ET++ K +E+L+++K + E + + Q+ + L V+ E+
Sbjct: 2171 E--QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ-RSQVEEELFS-VRVQMEEL 2226
Query: 444 KSVRSSVEAERKKLQREVEAQLEEVRKKSEKEIKQLEEEKAALNVKLQNSL-LEVLRLEE 502
+++ +EAE + L + + ++ +++KQ+ EE A L+V Q + L L E+
Sbjct: 2227 SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2286
Query: 503 FIQQNKTRPTGAEESPQELGRQHCSILETQDPCLKLDETSPRGEEYQDKLAAEEGT--SS 560
QQ +E Q + Q + L+ + L + Q +LA E+
Sbjct: 2287 LAQQRALAEKMLKEKMQAV--QEATRLKAEAELL----------QQQKELAQEQARRLQE 2334
Query: 561 DEEERTKVLLKEGSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQ-AQVSQMQQALEQC 619
D+E+ + L +E Q L + + ++LE ++++ KL+ A++S+ Q E
Sbjct: 2335 DKEQMAQQLAEETQGFQRTL------EAERQRQLEMSAEAERLKLRVAEMSRAQARAE-- 2386
Query: 620 TSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLEKARHQ--E 677
ED Q ++ ++ EKL R + TQ+ + LE Q++ E+ R E
Sbjct: 2387 -----EDAQRFRKQAEEIGEKLHRT-ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2440
Query: 678 LKATEERLKKESSHSLQIQHQTHRLELQALE-EKARQELQEERERMQAQQALLLESLRQE 736
L+ +E+L++E+ LQ++ + E+Q ++ E+ QE Q ++ +++ LL+ R
Sbjct: 2441 LEREKEKLQQEAK-LLQLKSE----EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF- 2494
Query: 737 LSEQQAACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGA 796
+ +++A +D A +LR QQ Q + ++A+ E Q + G
Sbjct: 2495 IEQEKAKLEQLFQDEVAKAQQLRE--EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2552
Query: 797 AGQGSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRAREVET 856
+ +LQ ++ R + E +E Q+LR+Q + LEE +A A E
Sbjct: 2553 R-----------RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2601
Query: 857 LRQEHRKEMQAMVADFSSAQAQLQARLAALEAELKDSGEKPGKGASR--------PEDLQ 908
+ A + + L A E E G + A R E+LQ
Sbjct: 2602 TASQ-----VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQ 2656
Query: 909 LIGRLQTRLKE---REDI 923
+ + T + E RED+
Sbjct: 2657 RLAQGHTTVDELARREDV 2674
Score = 122 bits (307), Expect = 1e-27
Identities = 165/741 (22%), Positives = 331/741 (44%), Gaps = 112/741 (15%)
Query: 51 ALNTRQDEAEASMEALRE---AHQEELQNAVAET---KARLLQEQGCAEEEALLQRIQAL 104
A +T + + +A +EA R+ A +EE + AE K+ +E+ + +A L+ ++ L
Sbjct: 1941 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2000
Query: 105 ESALELQKRLTEEALAESA-SCRLETKERELRVEAEHAERVLTLSREMLELKADYERRLQ 163
++ +E +RL E A ESA +L + + R++AE + ++ EL+ ++
Sbjct: 2001 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2060
Query: 164 HLTS--HEATPQGRLPQESPETKSEPG-QGPEMQEVLLEVQRLR--VENQQLSKDYARKA 218
L EA R +E+ E + + + + + + E +RL+ E Q ++ A+ A
Sbjct: 2061 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2120
Query: 219 EELQATYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEH 278
E + E E EA R+A Q+ AL Q Q ++++ K+ + E L+ Q ++E +L
Sbjct: 2121 AE-KLRKEAEQEAARRA--QAEQAALRQKQAADAEMEKHKKFAEQTLR-QKAQVEQELTT 2176
Query: 279 RGRKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECR 338
++ + L E +Q L + EA ++ S+++ E+L + +M
Sbjct: 2177 LRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE-------EELFSVRVQM------ 2223
Query: 339 GTQQTDAMKTELVSENK--VLREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEAS 396
++ +K + +EN+ +LR++++ T++
Sbjct: 2224 --EELSKLKARIEAENRALILRDKDN----------------------------TQRFLQ 2253
Query: 397 AETEYMKQQYEEDLR-KIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERK 455
E E MKQ EE R + Q + L + EDL ++ + K ++ ++A ++
Sbjct: 2254 EEAEKMKQVAEEAARLSVAAQEAARLRQLAE------EDLAQQRALAEKMLKEKMQAVQE 2307
Query: 456 KLQREVEAQLEEVRKK-SEKEIKQLEEEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGA 514
+ + EA+L + +K+ ++++ ++L+E+K + +L R E +Q +
Sbjct: 2308 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL----- 2362
Query: 515 EESPQELGRQHCSILETQDPCLKLDETSPR----GEEYQDKLAAEEGTSSDEEE--RTKV 568
E E R + E + +E + R EE +KL E + ++ +T
Sbjct: 2363 -EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2421
Query: 569 LLKEGSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQ-----------QALE 617
+ ++ SD L+E ++++R +E Q + LQ + +MQ QAL+
Sbjct: 2422 IQRQQSDHD---AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2478
Query: 618 QCTSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLEKARHQE 677
Q + ++ L ++ + E+ KL++ Q+ A QL QR + +E+ R +
Sbjct: 2479 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV----AKAQQLREEQQRQQQQMEQERQRL 2534
Query: 678 LKATEERLKKESSHSLQIQHQTHRLELQALEEKARQE---LQEERERMQAQQALLLESLR 734
+ + EE +++ H + + + ELQ LE++ RQ+ L EE +R++ Q L
Sbjct: 2535 VASMEEARRRQ--HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL------ 2586
Query: 735 QELSEQQAACSGHQKDLEALQ 755
L EQ A H +++ A Q
Sbjct: 2587 --LEEQHRAALAHSEEVTASQ 2605
Score = 108 bits (269), Expect = 3e-23
Identities = 212/1014 (20%), Positives = 408/1014 (40%), Gaps = 182/1014 (17%)
Query: 63 MEALREAHQEE--LQNAVAETKARLLQEQGCAEEEALLQRIQA-LESALELQKRLTEEAL 119
+++L + QEE Q ++E K LQ + C R+ E A E +R+ E+
Sbjct: 955 LQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQK 1014
Query: 120 AESASCRLETKERELRVEAE---------------HAERVLTLSR--EMLELKADYERRL 162
A++ L L EAE +E LTL + ++ L A Y +L
Sbjct: 1015 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1074
Query: 163 QHLTSHEATPQG-----RLPQES-PETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYAR 216
+ ++ QG R +E E ++ P PE++ +++LR + + +
Sbjct: 1075 KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1134
Query: 217 KAEELQATYE---------RENEAIRQAMQQSVSQALWQWQE-------KESDL------ 254
+EL+ E E + + ++ V+Q L +WQ ++ +L
Sbjct: 1135 LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ 1194
Query: 255 -------------------RKNFQVQ------ESALQAQVRKLEG---DLEHRGRKISDL 286
R+ Q+Q A++ Q+R+ + ++E G K+ +
Sbjct: 1195 LRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEEC 1254
Query: 287 KKYAQKLKERIQDLDVQLKEARQENSELKGTAKK----LGEKLAVAKD------------ 330
+++A++ I+D ++QL + + + AKK G + + +
Sbjct: 1255 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1314
Query: 331 -------------RMMLQECRGTQQTDAMKTELVSENKVLREENDLEAGNLHPQQDQSCL 377
R M +E R +Q A + E ++E + E+ + H Q
Sbjct: 1315 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKAQAE 1373
Query: 378 KECPCM--KGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEE------KKHLKDQLV 429
+E + + ++ ++EA+ + + K+ +E+L++++ +E E + ++
Sbjct: 1374 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1433
Query: 430 KRLEDLVKKHTVEIKSV---RSSVEAERKKLQ---REVEAQLEEVRKKSEKEIKQLEEE- 482
R+E+ ++ +++++ R E E + L+ E EAQ + ++++E+ +Q+++E
Sbjct: 1434 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1493
Query: 483 --KAALNVKLQNSL---LEVLR--------LEEFIQQNKTRPTGAEESPQELGRQHCSIL 529
K V+L + + E R LEE Q + ++ E RQ L
Sbjct: 1494 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1553
Query: 530 ETQDPCLKLDETSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLGSLLKEKTS 589
ET + + S R + +K A E S EE L+E ++ + + +
Sbjct: 1554 ETAQRSAEAELQSKRA-SFAEKTAQLE-RSLQEEHVAVAQLREEAERRAQQQAEAERARE 1611
Query: 590 KIQRLEEDWQ-----SQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQRE 644
+ +R E WQ + + +LQA+ Q++L Q +A KQ + ERE +R
Sbjct: 1612 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQA--------EAEKQKEEAEREARRRG 1663
Query: 645 LQETTQQNHAMKAQLEASHQRALRMLEKARHQELKATEE--RLKKESSHSLQIQHQTHRL 702
E A+ E QR ++ E Q L A +E RL+ E+ Q Q Q
Sbjct: 1664 KAEEQAVRQRELAEQELEKQR--QLAEGTAQQRLAAEQELIRLRAETEQGEQ-QRQLLEE 1720
Query: 703 ELQALEEKA------RQELQEERERMQAQQALLLESLRQELSEQQAACSGHQKDLEALQA 756
EL L+ +A RQEL+ E +++A+ +LL S + E ++ ++ LEA
Sbjct: 1721 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1780
Query: 757 ELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGAAGQ---GSGEGCGLWEENAQ 813
R L + A + + E Q + GE L +
Sbjct: 1781 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL---KTE 1837
Query: 814 LQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRAREVETLRQEHRK-------EMQ 866
+ A++ AE E+ ++ A+ QRR LEE Q AQ ++E + RK +
Sbjct: 1838 AEIALKEKEAENERLRRLAEDEAFQRRRLEE-QAAQHKADIEERLAQLRKASDSELERQK 1896
Query: 867 AMVADFSSAQAQLQARLAALEAELKDSGEKPGKGASRPEDLQL-IGRLQTRLKE 919
+V D + Q++ + AL+A + K A+ +L+L +GR+++ ++
Sbjct: 1897 GLVEDTLRQRRQVEEEILALKASFE-------KAAAGKAELELELGRIRSNAED 1943
Score = 66.6 bits (161), Expect = 1e-10
Identities = 87/381 (22%), Positives = 166/381 (43%), Gaps = 25/381 (6%)
Query: 56 QDEAEASMEALREAHQEEL---QNAVAETKARLLQEQGCAEEEALLQRIQALESALELQK 112
+++ +A EA R + EL Q +A+ +AR LQE + L + Q + LE ++
Sbjct: 2299 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2358
Query: 113 RLTEEALAESASCRLETKERELRVEAEHAERVLTLSREMLELKADYERRLQHLTSHEATP 172
+ E AE+ RL+ + E+ AE R+ E + R + T + T
Sbjct: 2359 QRQLEMSAEAE--RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2416
Query: 173 QGRLPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYARKAEELQATYERENEAI 232
L + ++ + ++E + E++R + + QQ +K K+EE+Q + +
Sbjct: 2417 VQTLEIQRQQSDHD---AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2473
Query: 233 RQAMQQSVSQALWQWQEKESDL-RKNFQVQESALQAQVRKLEGDLEHRGRKISDLKKYAQ 291
QA+QQS EK+S L R+ F QE A Q+ + ++ + + ++ Q
Sbjct: 2474 TQALQQSF------LSEKDSLLQRERFIEQEKAKLEQL--FQDEVAKAQQLREEQQRQQQ 2525
Query: 292 KLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECRGTQQTDAMKTELV 351
++++ Q L ++EAR+ E + ++ E+L + + Q+ R ++ A + + +
Sbjct: 2526 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL-----QQLEQQRRQQEELLAEENQRL 2580
Query: 352 SENKVLREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEASAETEYMKQQYEEDLR 411
E L EE A + S + + G D A AE E+ ++ R
Sbjct: 2581 REQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEH---SFDGLRR 2637
Query: 412 KIKHQTEEEKKHLKDQLVKRL 432
K+ Q +E L + ++RL
Sbjct: 2638 KVSAQRLQEAGILSAEELQRL 2658
Score = 55.5 bits (132), Expect = 3e-07
Identities = 114/568 (20%), Positives = 238/568 (41%), Gaps = 38/568 (6%)
Query: 385 GGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDL-VKKHTVEI 443
GG + + A E Y++ L+ ++ +EE + + + L+D+ ++ E
Sbjct: 930 GGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRC--QRCISELKDIRLQLEACET 987
Query: 444 KSVRSSVEAERKKLQREVEAQLEEVRKKSEKEIKQLEEEKAALNVKLQN--SLLEVLRLE 501
++V K+ RE ++ E ++K++ E++ L + A L+ + + +L E
Sbjct: 988 RTVHRLRLPLDKEPARECAQRIAE-QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAA 1046
Query: 502 EFIQQNKTRPTGAEESPQELGRQHCSILETQDPCLKLDETSP---RGEEYQDKLAAEEGT 558
++ G E + L + L+T ++ + + R E Q K A
Sbjct: 1047 PTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1106
Query: 559 SSDEEERTKVLLKE---GSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQQA 615
+ E E TK LK+ ++ Q P L+++ Q + E Q + + +V + ++
Sbjct: 1107 TLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1166
Query: 616 LEQCTSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLEKARH 675
+ Q ++ L A + E E+L R+L+ + + A L+ + +R ++
Sbjct: 1167 VAQLLERWQAVL-AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ-EQIQAMPL 1224
Query: 676 QELKATEERLKKESSHSLQIQHQTHRLE-LQALEEKARQELQEERERMQAQQALL--LES 732
+ +A E+L++E + +I+ ++E Q ++ +++ ++ +A L + S
Sbjct: 1225 ADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVAS 1284
Query: 733 LRQELSEQQAACSGHQK--DLEALQAELRALGRQQA---SSQCPGDSKDHIIATEERGGP 787
++ Q + S Q+ DL +EL L Q S ++ +A ++R
Sbjct: 1285 PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE 1344
Query: 788 GQAGSPPGAAGQGSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQ 847
+ + AA + + L E +AQ + R E++Q QE R++ + Q+
Sbjct: 1345 RERLAEVEAALEKQRQ---LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1401
Query: 848 AQRAREVETLRQEHRKEMQAM-----VADFSSAQAQLQARLAALEAELKDSGEKPGKGAS 902
E++ LRQ E+QA A+ S + + + R+ L+ E + +G
Sbjct: 1402 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG-- 1459
Query: 903 RPEDLQLIGRLQTRLKEREDIIKQLTEE 930
+LQ L+ R +E E +Q EE
Sbjct: 1460 ---ELQ---ALRARAEEAEAQKRQAQEE 1481
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 142 bits (358), Expect = 2e-33
Identities = 228/975 (23%), Positives = 427/975 (43%), Gaps = 117/975 (12%)
Query: 55 RQDEAEASMEALREAHQEEL----QNAVAETKARLLQEQGC------AEEEALLQRIQ-- 102
R++EA + + + QEEL Q++ AE +A+ Q + EEE + R+Q
Sbjct: 1430 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1489
Query: 103 -------ALESALELQKRLTEEALAESASCRLETKERELRVEAEHAERVLTLSREMLELK 155
E L+ + EEA A+ + E + +V+ E + +K
Sbjct: 1490 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1549
Query: 156 ADYERRLQHLTSHEATPQGRLPQESPETK---SEPGQGPEMQEVLLEVQR-LRVENQQLS 211
A+ E + + +A + RL E E + +E + ++Q L QR E Q
Sbjct: 1550 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1609
Query: 212 KDYARKAEELQATYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRK 271
+A K +L+ + + E+ A+ Q +++ +A Q Q A +A+ +
Sbjct: 1610 ASFAEKTAQLERSLQEEHVAVAQLREEAERRA---------------QQQAEAERAR-EE 1653
Query: 272 LEGDLEHRGRKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLG--EKLAVAK 329
E +LE K ++ + + +E Q + EA ++ E + A++ G E+ AV +
Sbjct: 1654 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1713
Query: 330 DRMMLQECRGTQQ--TDAMKTELVSENKVLREENDLEAGNLHPQQDQSCLKECPCMKGGT 387
+ QE +Q + L +E +++R + E G QQ Q +E ++
Sbjct: 1714 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE---QQRQLLEEELARLQREA 1770
Query: 388 DMQTKKEASAETEYMKQQYE-EDLRKIKHQTEEEKKHLKDQLVKRLE-DLVKKHTVEIKS 445
T+K E E K + E E L K + EEE + ++ +RLE + + + ++
Sbjct: 1771 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1830
Query: 446 VRSSVEAERKKLQREVEAQLEEVRKKSEKEIKQLEEEKAALNVKLQNSLLEVLRLEEFIQ 505
R AE K QR++ A+ + R+++E E + L E+ AA+ + + L+E
Sbjct: 1831 ARLRALAEEAKRQRQL-AEEDAARQRAEAE-RVLAEKLAAIGEATRLKTEAEIALKEKEA 1888
Query: 506 QNKTRPTGAEESPQELGRQHCSILETQDPCLKLDETSPRGEEYQDKLAAEEGTSSDEEER 565
+N+ AE+ + R LE Q K D +++LA S E ER
Sbjct: 1889 ENERLRRLAEDEAFQRRR-----LEEQAAQHKAD--------IEERLAQLRKASDSELER 1935
Query: 566 TKVLLKEGSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQ-QALEQCTSNYR 624
K L+++ + ++E+ ++ E + KA+L+ ++ +++ A + S +
Sbjct: 1936 QKGLVEDTLRQR----RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ 1991
Query: 625 EDLQALKQLS-DLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLE--KARHQELKAT 681
+L+A +Q E E+ +RE +E Q++ A + + + AL +E KA+ +E +
Sbjct: 1992 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRL 2051
Query: 682 EERLKKESSHSLQIQHQTHRLELQALEEKAR----QELQEERERMQAQQALLLESLRQEL 737
ER ++ES+ LQ+ + + LQA EEKA Q+ ++E ++ Q+ +L+ LR E
Sbjct: 2052 RERAEQESARQLQLAQEAAQKRLQA-EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2110
Query: 738 SEQQAACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGAA 797
+ A EA +A ++A R+ A S+ + + + + E + A
Sbjct: 2111 EAARRAAE------EAEEARVQA-EREAAQSRRQVEEAERLKQSAEEQAQAR------AQ 2157
Query: 798 GQGSGEGCGLWEENAQLQDAVRRLRAE---VEQHQQEAQKLRDQRRFLEET--QQAQRAR 852
Q + E E Q+A RR +AE + Q Q ++ ++F E+T Q+AQ +
Sbjct: 2158 AQAAAEKLRKEAE----QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2213
Query: 853 EVETLR-----QEHRK-----EMQAMVADFSSA---QAQLQARLAALEAELKDSGEKPGK 899
E+ TLR +H+K E+Q + A+ + A ++Q++ L ++ ++++ + K
Sbjct: 2214 ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL--K 2271
Query: 900 GASRPEDLQLIGR----LQTRLKEREDIIKQLTEERRFHYAAFPSAMSHRNRSFSFNPHP 955
E+ LI R Q L+E + +KQ+ EE A A R +
Sbjct: 2272 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2331
Query: 956 GYLTPSMKKKKVEDV 970
L M K+K++ V
Sbjct: 2332 RALAEKMLKEKMQAV 2346
Score = 138 bits (348), Expect = 2e-32
Identities = 222/971 (22%), Positives = 413/971 (42%), Gaps = 141/971 (14%)
Query: 47 KVIYALNTRQDEAEASMEALREAHQEELQNAVAETKARLLQEQGCAEEEALLQRIQALES 106
+ + AL + +AE + LR+A E + + + L Q AE E +R E
Sbjct: 1560 RALQALEELRLQAEEAERRLRQAEVERAR----QVQVALETAQRSAEAELQSKRASFAEK 1615
Query: 107 ALELQKRLTEEALAESASCRLETKER-ELRVEAEHAERVLTLSREMLELKADYERRLQHL 165
+L++ L EE +A A R E + R + + EAE A E +LKA+ RL+ L
Sbjct: 1616 TAQLERSLQEEHVA-VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR-L 1673
Query: 166 TSHEATPQGRLPQESPETKSEPGQGPEMQEVLLEVQRLR---VENQQLSKDYARKAEELQ 222
+ E Q L Q E + E + + E Q +R + Q+L K Q
Sbjct: 1674 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1733
Query: 223 ATYERENEAIR--------QAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEG 274
E E IR + +Q + + L + Q + + + Q E+ L ++E
Sbjct: 1734 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEV 1793
Query: 275 DLEHRGRKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAK----- 329
L + R + + ++K K+R++ + +E +E + L+ A++ + +A+
Sbjct: 1794 LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR 1853
Query: 330 -----DRMMLQECRGTQQTDAMKTEL-------VSENKVLREENDLEAGNLHPQQDQSCL 377
+R++ ++ + +KTE +EN+ LR + EA ++Q+
Sbjct: 1854 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ 1913
Query: 378 KECPCMKGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVK------- 430
+ + Q +K + +E E K E+ LR+ + Q EEE LK K
Sbjct: 1914 HKADIEE--RLAQLRKASDSELERQKGLVEDTLRQ-RRQVEEEILALKASFEKAAAGKAE 1970
Query: 431 ----------RLEDLVK-KHTVEIKSVRS-SVEAERKKLQREVEAQLEEVRKKSEKEIKQ 478
ED ++ K E+++ R + AE ++ +RE E E V+K E +
Sbjct: 1971 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE---ERVQKSLAAEEEA 2027
Query: 479 LEEEKAALN--VKLQNSLLEVLRLEEFIQQNKTRPTG-AEESPQE--LGRQHCSILETQD 533
+ KAAL +L+ + E RL E +Q R A+E+ Q+ + Q
Sbjct: 2028 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2087
Query: 534 PCLKLDETSPRGEEYQDKLAAEEGT---SSDEEERTKVLLKEGSDPQPPLGSLLKEKTSK 590
+L +T + + D+L E +++E E +V ++ + E+ +
Sbjct: 2088 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV----QAEREAAQSRRQVEEAER 2143
Query: 591 IQRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQAL---KQLSDLEREKLQRELQE 647
+++ E+ +A+ QA ++++ EQ + + QA KQ +D E EK ++ ++
Sbjct: 2144 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2203
Query: 648 TTQQNHAMKAQLEASHQRALRMLEKARHQELKATEE--RLKKESSHSLQIQHQTH----- 700
T +Q KAQ+E LE+ HQ+ EE RLK E++ + + + Q
Sbjct: 2204 TLRQ----KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2259
Query: 701 -RLELQALEE-KARQE-----------------LQEERERMQ--AQQALLLESLRQELSE 739
R++++ L + KAR E LQEE E+M+ A++A L QE +
Sbjct: 2260 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2319
Query: 740 QQAACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGAAGQ 799
+ ++DL A+ RAL + K+ + A +E A +
Sbjct: 2320 LRQLA---EEDL----AQQRALAEKML--------KEKMQAVQE-------------ATR 2351
Query: 800 GSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRAREVETLRQ 859
E L ++ Q+ RRL+ E +Q AQ+L ++ + + T +A+R R++E +
Sbjct: 2352 LKAEAELLQQQKELAQEQARRLQ---EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2408
Query: 860 EHRKEMQAMVADFSSAQAQLQARLAALEAELKDSGEKPGK-GASRPEDLQLIGRLQTRLK 918
R +++ VA+ S AQA+ + + ++ GEK + + E + L+ L+ + +
Sbjct: 2409 AERLKLR--VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ 2466
Query: 919 EREDIIKQLTE 929
+ + ++L E
Sbjct: 2467 QSDHDAERLRE 2477
Score = 128 bits (322), Expect = 2e-29
Identities = 206/918 (22%), Positives = 397/918 (43%), Gaps = 132/918 (14%)
Query: 58 EAEASMEALREAHQEELQNAVAETKA---RLLQEQGCAE----EEALLQRIQALESALEL 110
EAE +++ +EA E L+ +AE +A R L+EQ EE L Q +A +S LE
Sbjct: 1878 EAEIALKE-KEAENERLRR-LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1935
Query: 111 QKRLTEEAL-------------------AESASCRLETKERELRVEAEHAERVLTLSREM 151
QK L E+ L A + LE + +R AE R S+E
Sbjct: 1936 QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR----SKEQ 1991
Query: 152 LELKADYERRLQHLTSHEATPQGRLPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLS 211
EL+A +R+L Q+S + E + + + L EV+RL+ + ++
Sbjct: 1992 AELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR--QRKAALEEVERLKAKVEEAR 2049
Query: 212 KDYARKAEELQATYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRK 271
+ R +E + EA ++ +Q + Q+KE +L++ Q ++S L +
Sbjct: 2050 RLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD----Q 2105
Query: 272 LEGDLEHRGRKISDLK-------KYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEK 324
L G+ E R + + + A + + ++++ + +LK++ +E ++ + A+ EK
Sbjct: 2106 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-RLKQSAEEQAQARAQAQAAAEK 2164
Query: 325 LAVAKDRMMLQECRGTQQTDAMKTELVSENKVLREENDLEAG-NLHPQQDQSCLKECPCM 383
L + +Q A + + +E LR++ +A H + + L++ +
Sbjct: 2165 LR-----------KEAEQEAARRAQ--AEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2211
Query: 384 KGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEI 443
+ ++ T + ET++ K +E+L+++K + E + + Q+ + L V+ E+
Sbjct: 2212 E--QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQ-RSQVEEELFS-VRVQMEEL 2267
Query: 444 KSVRSSVEAERKKLQREVEAQLEEVRKKSEKEIKQLEEEKAALNVKLQNSL-LEVLRLEE 502
+++ +EAE + L + + ++ +++KQ+ EE A L+V Q + L L E+
Sbjct: 2268 SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2327
Query: 503 FIQQNKTRPTGAEESPQELGRQHCSILETQDPCLKLDETSPRGEEYQDKLAAEEGT--SS 560
QQ +E Q + Q + L+ + L + Q +LA E+
Sbjct: 2328 LAQQRALAEKMLKEKMQAV--QEATRLKAEAELL----------QQQKELAQEQARRLQE 2375
Query: 561 DEEERTKVLLKEGSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQ-AQVSQMQQALEQC 619
D+E+ + L +E Q L + + ++LE ++++ KL+ A++S+ Q E
Sbjct: 2376 DKEQMAQQLAEETQGFQRTL------EAERQRQLEMSAEAERLKLRVAEMSRAQARAE-- 2427
Query: 620 TSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLEKARHQ--E 677
ED Q ++ ++ EKL R + TQ+ + LE Q++ E+ R E
Sbjct: 2428 -----EDAQRFRKQAEEIGEKLHRT-ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2481
Query: 678 LKATEERLKKESSHSLQIQHQTHRLELQALE-EKARQELQEERERMQAQQALLLESLRQE 736
L+ +E+L++E+ LQ++ + E+Q ++ E+ QE Q ++ +++ LL+ R
Sbjct: 2482 LEREKEKLQQEAK-LLQLKSE----EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF- 2535
Query: 737 LSEQQAACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGA 796
+ +++A +D A +LR QQ Q + ++A+ E Q + G
Sbjct: 2536 IEQEKAKLEQLFQDEVAKAQQLRE--EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2593
Query: 797 AGQGSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRAREVET 856
+ +LQ ++ R + E +E Q+LR+Q + LEE +A A E
Sbjct: 2594 R-----------RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2642
Query: 857 LRQEHRKEMQAMVADFSSAQAQLQARLAALEAELKDSGEKPGKGASR--------PEDLQ 908
+ A + + L A E E G + A R E+LQ
Sbjct: 2643 TASQ-----VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQ 2697
Query: 909 LIGRLQTRLKE---REDI 923
+ + T + E RED+
Sbjct: 2698 RLAQGHTTVDELARREDV 2715
Score = 122 bits (307), Expect = 1e-27
Identities = 165/741 (22%), Positives = 331/741 (44%), Gaps = 112/741 (15%)
Query: 51 ALNTRQDEAEASMEALRE---AHQEELQNAVAET---KARLLQEQGCAEEEALLQRIQAL 104
A +T + + +A +EA R+ A +EE + AE K+ +E+ + +A L+ ++ L
Sbjct: 1982 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2041
Query: 105 ESALELQKRLTEEALAESA-SCRLETKERELRVEAEHAERVLTLSREMLELKADYERRLQ 163
++ +E +RL E A ESA +L + + R++AE + ++ EL+ ++
Sbjct: 2042 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2101
Query: 164 HLTS--HEATPQGRLPQESPETKSEPG-QGPEMQEVLLEVQRLR--VENQQLSKDYARKA 218
L EA R +E+ E + + + + + + E +RL+ E Q ++ A+ A
Sbjct: 2102 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2161
Query: 219 EELQATYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEH 278
E + E E EA R+A Q+ AL Q Q ++++ K+ + E L+ Q ++E +L
Sbjct: 2162 AE-KLRKEAEQEAARRA--QAEQAALRQKQAADAEMEKHKKFAEQTLR-QKAQVEQELTT 2217
Query: 279 RGRKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECR 338
++ + L E +Q L + EA ++ S+++ E+L + +M
Sbjct: 2218 LRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE-------EELFSVRVQM------ 2264
Query: 339 GTQQTDAMKTELVSENK--VLREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEAS 396
++ +K + +EN+ +LR++++ T++
Sbjct: 2265 --EELSKLKARIEAENRALILRDKDN----------------------------TQRFLQ 2294
Query: 397 AETEYMKQQYEEDLR-KIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERK 455
E E MKQ EE R + Q + L + EDL ++ + K ++ ++A ++
Sbjct: 2295 EEAEKMKQVAEEAARLSVAAQEAARLRQLAE------EDLAQQRALAEKMLKEKMQAVQE 2348
Query: 456 KLQREVEAQLEEVRKK-SEKEIKQLEEEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGA 514
+ + EA+L + +K+ ++++ ++L+E+K + +L R E +Q +
Sbjct: 2349 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL----- 2403
Query: 515 EESPQELGRQHCSILETQDPCLKLDETSPR----GEEYQDKLAAEEGTSSDEEE--RTKV 568
E E R + E + +E + R EE +KL E + ++ +T
Sbjct: 2404 -EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2462
Query: 569 LLKEGSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQ-----------QALE 617
+ ++ SD L+E ++++R +E Q + LQ + +MQ QAL+
Sbjct: 2463 IQRQQSDHD---AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ 2519
Query: 618 QCTSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLEKARHQE 677
Q + ++ L ++ + E+ KL++ Q+ A QL QR + +E+ R +
Sbjct: 2520 QSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV----AKAQQLREEQQRQQQQMEQERQRL 2575
Query: 678 LKATEERLKKESSHSLQIQHQTHRLELQALEEKARQE---LQEERERMQAQQALLLESLR 734
+ + EE +++ H + + + ELQ LE++ RQ+ L EE +R++ Q L
Sbjct: 2576 VASMEEARRRQ--HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL------ 2627
Query: 735 QELSEQQAACSGHQKDLEALQ 755
L EQ A H +++ A Q
Sbjct: 2628 --LEEQHRAALAHSEEVTASQ 2646
Score = 108 bits (269), Expect = 3e-23
Identities = 212/1014 (20%), Positives = 408/1014 (40%), Gaps = 182/1014 (17%)
Query: 63 MEALREAHQEE--LQNAVAETKARLLQEQGCAEEEALLQRIQA-LESALELQKRLTEEAL 119
+++L + QEE Q ++E K LQ + C R+ E A E +R+ E+
Sbjct: 996 LQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQK 1055
Query: 120 AESASCRLETKERELRVEAE---------------HAERVLTLSR--EMLELKADYERRL 162
A++ L L EAE +E LTL + ++ L A Y +L
Sbjct: 1056 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1115
Query: 163 QHLTSHEATPQG-----RLPQES-PETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYAR 216
+ ++ QG R +E E ++ P PE++ +++LR + + +
Sbjct: 1116 KTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA 1175
Query: 217 KAEELQATYE---------RENEAIRQAMQQSVSQALWQWQE-------KESDL------ 254
+EL+ E E + + ++ V+Q L +WQ ++ +L
Sbjct: 1176 LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ 1235
Query: 255 -------------------RKNFQVQ------ESALQAQVRKLEG---DLEHRGRKISDL 286
R+ Q+Q A++ Q+R+ + ++E G K+ +
Sbjct: 1236 LRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEEC 1295
Query: 287 KKYAQKLKERIQDLDVQLKEARQENSELKGTAKK----LGEKLAVAKD------------ 330
+++A++ I+D ++QL + + + AKK G + + +
Sbjct: 1296 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1355
Query: 331 -------------RMMLQECRGTQQTDAMKTELVSENKVLREENDLEAGNLHPQQDQSCL 377
R M +E R +Q A + E ++E + E+ + H Q
Sbjct: 1356 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKAQAE 1414
Query: 378 KECPCM--KGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEE------KKHLKDQLV 429
+E + + ++ ++EA+ + + K+ +E+L++++ +E E + ++
Sbjct: 1415 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1474
Query: 430 KRLEDLVKKHTVEIKSV---RSSVEAERKKLQ---REVEAQLEEVRKKSEKEIKQLEEE- 482
R+E+ ++ +++++ R E E + L+ E EAQ + ++++E+ +Q+++E
Sbjct: 1475 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1534
Query: 483 --KAALNVKLQNSL---LEVLR--------LEEFIQQNKTRPTGAEESPQELGRQHCSIL 529
K V+L + + E R LEE Q + ++ E RQ L
Sbjct: 1535 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1594
Query: 530 ETQDPCLKLDETSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLGSLLKEKTS 589
ET + + S R + +K A E S EE L+E ++ + + +
Sbjct: 1595 ETAQRSAEAELQSKRA-SFAEKTAQLE-RSLQEEHVAVAQLREEAERRAQQQAEAERARE 1652
Query: 590 KIQRLEEDWQ-----SQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQRE 644
+ +R E WQ + + +LQA+ Q++L Q +A KQ + ERE +R
Sbjct: 1653 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQA--------EAEKQKEEAEREARRRG 1704
Query: 645 LQETTQQNHAMKAQLEASHQRALRMLEKARHQELKATEE--RLKKESSHSLQIQHQTHRL 702
E A+ E QR ++ E Q L A +E RL+ E+ Q Q Q
Sbjct: 1705 KAEEQAVRQRELAEQELEKQR--QLAEGTAQQRLAAEQELIRLRAETEQGEQ-QRQLLEE 1761
Query: 703 ELQALEEKA------RQELQEERERMQAQQALLLESLRQELSEQQAACSGHQKDLEALQA 756
EL L+ +A RQEL+ E +++A+ +LL S + E ++ ++ LEA
Sbjct: 1762 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1821
Query: 757 ELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGAAGQ---GSGEGCGLWEENAQ 813
R L + A + + E Q + GE L +
Sbjct: 1822 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL---KTE 1878
Query: 814 LQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRAREVETLRQEHRK-------EMQ 866
+ A++ AE E+ ++ A+ QRR LEE Q AQ ++E + RK +
Sbjct: 1879 AEIALKEKEAENERLRRLAEDEAFQRRRLEE-QAAQHKADIEERLAQLRKASDSELERQK 1937
Query: 867 AMVADFSSAQAQLQARLAALEAELKDSGEKPGKGASRPEDLQL-IGRLQTRLKE 919
+V D + Q++ + AL+A + K A+ +L+L +GR+++ ++
Sbjct: 1938 GLVEDTLRQRRQVEEEILALKASFE-------KAAAGKAELELELGRIRSNAED 1984
Score = 66.6 bits (161), Expect = 1e-10
Identities = 87/381 (22%), Positives = 166/381 (43%), Gaps = 25/381 (6%)
Query: 56 QDEAEASMEALREAHQEEL---QNAVAETKARLLQEQGCAEEEALLQRIQALESALELQK 112
+++ +A EA R + EL Q +A+ +AR LQE + L + Q + LE ++
Sbjct: 2340 KEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2399
Query: 113 RLTEEALAESASCRLETKERELRVEAEHAERVLTLSREMLELKADYERRLQHLTSHEATP 172
+ E AE+ RL+ + E+ AE R+ E + R + T + T
Sbjct: 2400 QRQLEMSAEAE--RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2457
Query: 173 QGRLPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYARKAEELQATYERENEAI 232
L + ++ + ++E + E++R + + QQ +K K+EE+Q + +
Sbjct: 2458 VQTLEIQRQQSDHD---AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2514
Query: 233 RQAMQQSVSQALWQWQEKESDL-RKNFQVQESALQAQVRKLEGDLEHRGRKISDLKKYAQ 291
QA+QQS EK+S L R+ F QE A Q+ + ++ + + ++ Q
Sbjct: 2515 TQALQQSF------LSEKDSLLQRERFIEQEKAKLEQL--FQDEVAKAQQLREEQQRQQQ 2566
Query: 292 KLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECRGTQQTDAMKTELV 351
++++ Q L ++EAR+ E + ++ E+L + + Q+ R ++ A + + +
Sbjct: 2567 QMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL-----QQLEQQRRQQEELLAEENQRL 2621
Query: 352 SENKVLREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEASAETEYMKQQYEEDLR 411
E L EE A + S + + G D A AE E+ ++ R
Sbjct: 2622 REQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEH---SFDGLRR 2678
Query: 412 KIKHQTEEEKKHLKDQLVKRL 432
K+ Q +E L + ++RL
Sbjct: 2679 KVSAQRLQEAGILSAEELQRL 2699
Score = 55.5 bits (132), Expect = 3e-07
Identities = 114/568 (20%), Positives = 238/568 (41%), Gaps = 38/568 (6%)
Query: 385 GGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDL-VKKHTVEI 443
GG + + A E Y++ L+ ++ +EE + + + L+D+ ++ E
Sbjct: 971 GGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRC--QRCISELKDIRLQLEACET 1028
Query: 444 KSVRSSVEAERKKLQREVEAQLEEVRKKSEKEIKQLEEEKAALNVKLQN--SLLEVLRLE 501
++V K+ RE ++ E ++K++ E++ L + A L+ + + +L E
Sbjct: 1029 RTVHRLRLPLDKEPARECAQRIAE-QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAA 1087
Query: 502 EFIQQNKTRPTGAEESPQELGRQHCSILETQDPCLKLDETSP---RGEEYQDKLAAEEGT 558
++ G E + L + L+T ++ + + R E Q K A
Sbjct: 1088 PTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1147
Query: 559 SSDEEERTKVLLKE---GSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQQA 615
+ E E TK LK+ ++ Q P L+++ Q + E Q + + +V + ++
Sbjct: 1148 TLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1207
Query: 616 LEQCTSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLEKARH 675
+ Q ++ L A + E E+L R+L+ + + A L+ + +R ++
Sbjct: 1208 VAQLLERWQAVL-AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ-EQIQAMPL 1265
Query: 676 QELKATEERLKKESSHSLQIQHQTHRLE-LQALEEKARQELQEERERMQAQQALL--LES 732
+ +A E+L++E + +I+ ++E Q ++ +++ ++ +A L + S
Sbjct: 1266 ADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVAS 1325
Query: 733 LRQELSEQQAACSGHQK--DLEALQAELRALGRQQA---SSQCPGDSKDHIIATEERGGP 787
++ Q + S Q+ DL +EL L Q S ++ +A ++R
Sbjct: 1326 PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE 1385
Query: 788 GQAGSPPGAAGQGSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQ 847
+ + AA + + L E +AQ + R E++Q QE R++ + Q+
Sbjct: 1386 RERLAEVEAALEKQRQ---LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1442
Query: 848 AQRAREVETLRQEHRKEMQAM-----VADFSSAQAQLQARLAALEAELKDSGEKPGKGAS 902
E++ LRQ E+QA A+ S + + + R+ L+ E + +G
Sbjct: 1443 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG-- 1500
Query: 903 RPEDLQLIGRLQTRLKEREDIIKQLTEE 930
+LQ L+ R +E E +Q EE
Sbjct: 1501 ---ELQ---ALRARAEEAEAQKRQAQEE 1522
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 138 bits (347), Expect = 3e-32
Identities = 199/919 (21%), Positives = 399/919 (43%), Gaps = 113/919 (12%)
Query: 47 KVIYALNTRQDEAEASMEALREAHQEELQNAVAETKARLLQEQGCAEEEALLQRIQA--- 103
K + ++ +++E A E L + +++L T+ LQ Q AE+ L +++QA
Sbjct: 835 KPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETE 894
Query: 104 -LESALELQKRLTEEALAESASCRLETKERELRVEAEHAERVLTLSREMLELKADYERRL 162
A EL+ RLT + C + E RVE E E R
Sbjct: 895 LCAEAEELRARLTAKKQELEEICH----DLEARVEEE-------------------EERC 931
Query: 163 QHLTSHEATPQGRLP--QESPETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYARKAEE 220
QHL + + Q + +E E + Q ++++V E + ++E +Q+ E+
Sbjct: 932 QHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQII------LED 985
Query: 221 LQATYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEHRG 280
+E + + + + + L + +EK L K ++ +A + LE L
Sbjct: 986 QNCKLAKEKKLLEDRIAEFTTN-LTEEEEKSKSLAK----LKNKHEAMITDLEERLRREE 1040
Query: 281 RKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECRGT 340
++ +L+K +KL+ DL Q+ E + + +ELK K E+L A R+ E
Sbjct: 1041 KQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARV---EEEAA 1097
Query: 341 QQTDAMKTELVSENKVLREENDLE----AGNLHPQQDQSCLKECPCMKGGTDMQTKKEAS 396
Q+ A+K E+++ + DLE + N +Q + +E +K T+++ +++
Sbjct: 1098 QKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALK--TELEDTLDST 1155
Query: 397 AETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERKK 456
A + ++ + E+++ +K EEE K + Q ++++ +KH+ ++ + AE+ +
Sbjct: 1156 AAQQELRSKREQEVNILKKTLEEEAKTHEAQ----IQEMRQKHSQAVEEL-----AEQLE 1206
Query: 457 LQREVEAQLEEVRKKSEKEIKQLEEEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEE 516
+ V+A LE+ ++ E E +L E L +S + ++E +Q+ + + E
Sbjct: 1207 QTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGER 1266
Query: 517 SPQELGRQHCSI-LETQDPCLKLDETSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSD 575
EL + + +E + L ++ + + +A E D +E LL+E +
Sbjct: 1267 VRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQE----LLQEENR 1322
Query: 576 PQPPLGSLLK----EKTSKIQRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQALK 631
+ L + LK EK S ++LEE+ + K L+ Q++ + + + + L+
Sbjct: 1323 QKLSLSTKLKQVEDEKNSFREQLEEE-EEAKHNLEKQIATLHAQVADMKKKMEDSVGCLE 1381
Query: 632 QLSDLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLEKARHQELKATEERLKKESSH 691
+++R KLQ++L+ +Q++ A + + R+ QEL L +
Sbjct: 1382 TAEEVKR-KLQKDLEGLSQRHEEKVAAYDKLEKTKTRL-----QQELDDLLVDLDHQRQS 1435
Query: 692 SLQIQHQTHRLELQALEEKA-RQELQEERERMQAQ------QALLLESLRQELSEQQAAC 744
+ ++ + + + EEK + EER+R +A+ +AL L +E EQ+A
Sbjct: 1436 ACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKA-- 1493
Query: 745 SGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGAAGQGSGEG 804
+LE L + R SS+ H + +R Q + E
Sbjct: 1494 -----ELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDEL 1548
Query: 805 CGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRAREVETLRQEHRKE 864
+ +L+ ++ ++A+ E+ Q RD++ ++ Q ++ RE+E ++ RK+
Sbjct: 1549 QATEDAKLRLEVNLQAMKAQFERDLQG----RDEQSEEKKKQLVRQVREMEAELEDERKQ 1604
Query: 865 MQAMVADFSSAQAQLQARLAALEAELKDSGEKPGKGASRPEDLQLIGRLQTRLKE----- 919
VA A+ +L+ L LEA + DS K +R E ++ + +LQ ++K+
Sbjct: 1605 RSMAVA----ARKKLEMDLKDLEAHI-DSANK-----NRDEAIKQLRKLQAQMKDCMREL 1654
Query: 920 ------REDIIKQLTEERR 932
RE+I+ Q E +
Sbjct: 1655 DDTRASREEILAQAKENEK 1673
Score = 133 bits (334), Expect = 1e-30
Identities = 215/1016 (21%), Positives = 423/1016 (41%), Gaps = 165/1016 (16%)
Query: 33 QMHVKMCKKIAQLTKVIYALNTRQDEAEASMEALREAHQEELQNAVAETK-----ARLLQ 87
Q ++C + +L + A +E +EA E +E Q+ AE K + L+
Sbjct: 890 QAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELE 949
Query: 88 EQGCAEEEALLQRIQ--ALESALELQKRLTEEALAESASCRLETKERELRVEAEHAERVL 145
EQ EEE+ Q++Q + + +L+K E+ + E +C+L KE++L +E AE
Sbjct: 950 EQ-LEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKL-AKEKKL-LEDRIAEFTT 1006
Query: 146 TL------SREMLELKADYERRLQHLTSHEATPQGRLPQESPETKSEPGQGPEMQEVLLE 199
L S+ + +LK +E + L + + + + G ++ + + E
Sbjct: 1007 NLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAE 1066
Query: 200 VQRLRVENQQLSKDYARKAEELQATYER-ENEAIRQAMQ-------QSVSQALWQWQEKE 251
+Q + +L A+K EELQA R E EA ++ M +S L + E E
Sbjct: 1067 LQ---AQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESE 1123
Query: 252 SDLRKNFQVQESALQAQVRKLEGDLEH-----------RGRKISDLKKYAQKLKERIQDL 300
R + Q+ L ++ L+ +LE R ++ ++ + L+E +
Sbjct: 1124 RASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTH 1183
Query: 301 DVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECRGTQQTDAMKTELVSENKVLRE- 359
+ Q++E RQ++S+ ++L E+L K R+ + Q + + EL +E KVL +
Sbjct: 1184 EAQIQEMRQKHSQ---AVEELAEQLEQTK-RVKANLEKAKQTLENERGELANEVKVLLQG 1239
Query: 360 -------------------------------------ENDLEAGNLHPQQDQSCLKECPC 382
+ +E N+ QS K
Sbjct: 1240 KGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKL 1299
Query: 383 MKGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDLVKKHTVE 442
K + ++++ + + E + + + L Q E+EK ++QL + E KH +E
Sbjct: 1300 TKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEE---AKHNLE 1356
Query: 443 --IKSVRSSVEAERKKLQREVEA--QLEEVRKKSEKEIK---QLEEEKAALNVKLQNSLL 495
I ++ + V +KK++ V EEV++K +K+++ Q EEK A KL+ +
Sbjct: 1357 KQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKT-- 1414
Query: 496 EVLRLEEFIQQNKTRPTGAEESPQELGRQHCSILETQDPCLKLDETSPRGEEYQDKLAAE 555
RL++ + ++ +L Q S + K D+ + K A E
Sbjct: 1415 -KTRLQQEL----------DDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEE 1463
Query: 556 EGTSSDE--EERTKVL-----LKEGSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQ 608
+ E E+ TK L L+E + + L L K+ +++ ED S K +
Sbjct: 1464 RDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEM----EDLMSSKDDVGKS 1519
Query: 609 VSQMQ---QALEQCTSNYREDLQALK-QLSDLEREKLQRELQETTQQNHAMKAQL----- 659
V +++ +ALEQ + L+ L+ +L E KL+ E+ AMKAQ
Sbjct: 1520 VHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEV-----NLQAMKAQFERDLQ 1574
Query: 660 ---EASHQRALRMLEKARHQELKATEERLKKESSHSLQIQHQTHRLELQALEEKARQELQ 716
E S ++ +++ + R E + +ER ++ + + + + + +L+A + A +
Sbjct: 1575 GRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRD 1634
Query: 717 EERERMQAQQALL------LESLRQELSEQQAACSGHQKDLEALQAELRALGRQQASSQC 770
E ++++ QA + L+ R E A ++K L++++AE+ L + A+++
Sbjct: 1635 EAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAE- 1693
Query: 771 PGDSKDHIIATEERGGPGQAGSPPGAAGQGSGEGCGLWEENAQLQDAVRRLRAEVEQHQQ 830
+R + SG+G EE +L+ + +L E+E+ Q
Sbjct: 1694 ----------RAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQG 1743
Query: 831 EAQKLRDQRRFLE------------ETQQAQRAREVETLRQEHRKEMQAMVADF-SSAQA 877
+ + D+ + E AQ+ + KE++ + + + ++
Sbjct: 1744 NTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKS 1803
Query: 878 QLQARLAALEAELKDSGEK-PGKGASRPEDLQLIGRLQTRLKEREDIIKQLTEERR 932
+ +A + ALEA++ E+ + R + + R + +LK D++ Q+ +ERR
Sbjct: 1804 KYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLK---DVLLQVDDERR 1856
Score = 114 bits (285), Expect = 5e-25
Identities = 180/841 (21%), Positives = 359/841 (42%), Gaps = 85/841 (10%)
Query: 143 RVLTLSREMLELKADYERRLQHLTSHEATPQGRLPQESPETKSEPGQGPEMQEVLLEVQR 202
R+ T + +L++ E + + +L E+ T+ E Q M E L ++
Sbjct: 829 RLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQ 888
Query: 203 LRVENQQLSKDYARKAEELQATYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQE 262
L+ E + ++ AEEL+A + + + + ++ E+E + ++
Sbjct: 889 LQAETELCAE-----AEELRARLTAKKQELEEICHDLEARV-----EEEEERCQH----- 933
Query: 263 SALQAQVRKLEGDLEHRGRKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLG 322
LQA+ +K++ +++ ++ + + QKL+ + +LK+ +E L+ KL
Sbjct: 934 --LQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLA 991
Query: 323 EKLAVAKDRMMLQECRGTQQTDAMKTELVSENKVLREENDLEAG-NLHPQQDQSCLKECP 381
++ + +DR+ T++ + K+ +NK DLE +Q Q K
Sbjct: 992 KEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRR 1051
Query: 382 CMKG-GTDMQTK-KEASAETEYMKQQY---EEDLRKIKHQTEEE--KKHLKDQLVKRLED 434
++G TD+ + E A+ +K Q EE+L+ + EEE +K++ + ++ LE
Sbjct: 1052 KLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELES 1111
Query: 435 LVKKHTVEIKSVRSS---VEAERKKLQREVEA---QLE----------EVRKKSEKEI-- 476
+ + +++S R+S E +++ L E+EA +LE E+R K E+E+
Sbjct: 1112 QISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNI 1171
Query: 477 --KQLEEE----KAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEESPQELGRQHCSILE 530
K LEEE +A + Q V L E ++Q K E++ Q L + +
Sbjct: 1172 LKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELAN 1231
Query: 531 TQDPCLKLDETSPRGEEYQDKLAAEEGTSSDEEERTKV-LLKEGSDPQPPLGS---LLKE 586
L+ S + + E +E ER + L + + Q L + LL +
Sbjct: 1232 EVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQ 1291
Query: 587 KTSKIQRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQRELQ 646
SK +L +D+ + L++Q+ Q+ L++ LKQ+ D E+ + +L+
Sbjct: 1292 SDSKSSKLTKDFSA----LESQLQDTQELLQEENRQKLSLSTKLKQVED-EKNSFREQLE 1346
Query: 647 ETTQQNHAMKAQLEASHQRALRMLEKARHQ-ELKATEERLKKESSHSLQIQHQTHRLELQ 705
E + H ++ Q+ H + M +K T E +K++ L+ Q H ++
Sbjct: 1347 EEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVA 1406
Query: 706 ALE--EKARQELQEERERM------QAQQALLLESLR----QELSEQQAACSGHQKDLEA 753
A + EK + LQ+E + + Q Q A LE + Q L+E++ + + ++ +
Sbjct: 1407 AYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDR 1466
Query: 754 LQAELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGAAGQGSGEGCGLWEENAQ 813
+AE R + S + A ER G + E
Sbjct: 1467 AEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHE---- 1522
Query: 814 LQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRAREV--ETLRQEHRKEMQAMVAD 871
L+ + R L +VE+ + + ++L D+ L+ T+ A+ EV + ++ + +++Q
Sbjct: 1523 LEKSKRALEQQVEEMKTQLEELEDE---LQATEDAKLRLEVNLQAMKAQFERDLQGRDEQ 1579
Query: 872 FSSAQAQLQARLAALEAELKDSGEKPGKGASRPEDLQ-----LIGRLQTRLKEREDIIKQ 926
+ QL ++ +EAEL+D ++ + + L+ L + + K R++ IKQ
Sbjct: 1580 SEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQ 1639
Query: 927 L 927
L
Sbjct: 1640 L 1640
Score = 111 bits (278), Expect = 3e-24
Identities = 174/863 (20%), Positives = 380/863 (44%), Gaps = 142/863 (16%)
Query: 63 MEALREAHQEELQNAVAETKARLLQEQGC-AEEEALLQRIQALESALELQKRLTEEALAE 121
+EAL+ ++ L + A+ + R +EQ ++ L + + E+ ++ ++ +A+ E
Sbjct: 1141 LEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEE 1200
Query: 122 SASCRLETKERELRVEAEHAERVLTLSREMLELKADYERRLQHLTSHEATPQGRLPQESP 181
A E E+ RV+A + TL E EL + + LQ E + ++ +
Sbjct: 1201 LA----EQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRK-KVEAQLQ 1255
Query: 182 ETKSEPGQGPEMQEVLLE-VQRLRVE--------------NQQLSKDYARKAEELQATYE 226
E + + +G ++ L + V +L+VE + +L+KD++ +LQ T E
Sbjct: 1256 ELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQE 1315
Query: 227 RENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEHRGRKISDL 286
E RQ + S+S L Q +++++ R+ + +E A LE + +++D+
Sbjct: 1316 LLQEENRQKL--SLSTKLKQVEDEKNSFREQLEEEEEAKH----NLEKQIATLHAQVADM 1369
Query: 287 KKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECRGTQQTDAM 346
KK K+++ + L+ + R+ +L+G +++ EK+A A D++ + R Q+ D +
Sbjct: 1370 KK---KMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVA-AYDKLEKTKTRLQQELDDL 1425
Query: 347 KTELVSE--------------NKVLREENDLEAGNLHPQ---QDQSCLKECPCMKGGTDM 389
+L + +++L EE + A + + ++ KE + +
Sbjct: 1426 LVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARAL 1485
Query: 390 QTKKEASAETEYMKQQY----------EEDLRKIKHQTEEEKKHLKDQL------VKRLE 433
+ E AE E + +Q+ ++D+ K H+ E+ K+ L+ Q+ ++ LE
Sbjct: 1486 EEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELE 1545
Query: 434 DLVKKHTVEIKSVRSSVEAERKKLQREVEAQLEEVRKKSEKEIKQLEEEKAALNVKLQNS 493
D ++ + +++A + + +R+++ + E+ +K ++ ++Q+ E +A L + +
Sbjct: 1546 DELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQR 1605
Query: 494 LLEVL---RLEEFIQQNKTRPTGAEESPQELGRQHCSILETQDPCLK-LDETSPRGEEYQ 549
+ V +LE ++ + A ++ E +Q + C++ LD+T EE
Sbjct: 1606 SMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREE-- 1663
Query: 550 DKLAAEEGTSSDEEERTKVLLKEGSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQV 609
+L + + + L S+ E IQ EE +++AK QAQ
Sbjct: 1664 -------------------ILAQAKENEKKLKSMEAEM---IQLQEELAAAERAKRQAQQ 1701
Query: 610 SQMQQALEQCTSNYREDLQALKQLSDLERE--KLQRELQETTQQNHAMKAQLEASHQRAL 667
+ + A E S+ + L AL++ LE +L+ EL+E + +L+ ++ L
Sbjct: 1702 ERDELADEIANSSGKGAL-ALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKAN---L 1757
Query: 668 RMLEKARHQELKATEERLKKESSHSLQIQHQTHRLELQALEEKARQELQEERERMQAQQA 727
++ + L+ + + + + L+ Q++ +++LQ +E + + + ++A+ A
Sbjct: 1758 QIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIA 1817
Query: 728 LLLESLRQELSEQQAACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIATEERGGP 787
L E L E E+QAAC ++ + L+ L + ++ +++ D D
Sbjct: 1818 QLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQAD----------- 1866
Query: 788 GQAGSPPGAAGQGSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLE---- 843
+ +++L+ ++E+ ++EAQ+ RR L+
Sbjct: 1867 -------------------------KASTRLKQLKRQLEEAEEEAQRANASRRKLQRELE 1901
Query: 844 ---ETQQAQRAREVETLRQEHRK 863
ET A REV +L+ + R+
Sbjct: 1902 DATETADAMN-REVSSLKNKLRR 1923
Score = 98.6 bits (244), Expect = 3e-20
Identities = 138/656 (21%), Positives = 283/656 (43%), Gaps = 96/656 (14%)
Query: 51 ALNTRQDEAEASMEALREAHQEE-------------LQNAVAETKARLLQEQGCAEEEAL 97
+L+T+ + E + RE +EE L VA+ K ++ GC E
Sbjct: 1326 SLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEE 1385
Query: 98 LQRIQALESALELQKRLTEEALA-----ESASCRLETKERELRVEAEHAERVLTLSREML 152
++R L+ LE + EE +A E RL+ + +L V+ +H + S L
Sbjct: 1386 VKR--KLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQ----SACNL 1439
Query: 153 ELKADYERRLQHLTSHEATPQGRLPQE----SPETKSEPGQGPEMQEVLLEVQRLRVENQ 208
E K +++ L + E T + +E E + + + + L E + E +
Sbjct: 1440 EKK---QKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELE 1496
Query: 209 QLSKDYARKAEELQATYE------RENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQ- 261
+L+K + + E+L ++ + E E ++A++Q V + Q +E E +L+ +
Sbjct: 1497 RLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKL 1556
Query: 262 --ESALQAQVRKLEGDLEHRGRKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAK 319
E LQA + E DL+ R + + KK +L ++++++ +L++ R++ S K
Sbjct: 1557 RLEVNLQAMKAQFERDLQGRDEQSEEKKK---QLVRQVREMEAELEDERKQRSMAVAARK 1613
Query: 320 KLGEKLAVAKDRMMLQECRGTQQTDAMKT--ELVSENK-VLREENDLEAGNLHPQQDQSC 376
KL L KD + + +A+K +L ++ K +RE +D A ++ +
Sbjct: 1614 KLEMDL---KDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASR---EEILAQ 1667
Query: 377 LKECPCMKGGTDMQTKKEASAETEYMKQQYE-EDLRKIKHQTEEEKKHLKDQLVKRLEDL 435
KE KK S E E ++ Q E + K Q ++E+ L D++
Sbjct: 1668 AKE----------NEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIAN----- 1712
Query: 436 VKKHTVEIKSVRSSVEAERKKLQREVEAQLEEVRKKSEKEIKQLEEEKAALNVKLQNSLL 495
S + ++ E K R +EA++ ++ E+E+++ + +N +L+ + L
Sbjct: 1713 --------SSGKGALALEEK---RRLEARIAQL----EEELEEEQGNTELINDRLKKANL 1757
Query: 496 EVLRLEEFIQQNKTRPTGAEESPQELGRQHCSI---LETQDPCLKLDETSPRGEEYQDKL 552
++ ++ + ++ E + Q+L RQ+ + L+ + +K + + K+
Sbjct: 1758 QIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVK-SKYKASITALEAKI 1816
Query: 553 AAEEGTSSDEEERTKVLLKEGSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQM 612
A E +E + + K+ + L +L + + +R E ++ Q K ++ Q+
Sbjct: 1817 AQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDE-RRNAEQYKDQADKASTRLKQL 1875
Query: 613 QQALEQCTSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMKAQLEASHQRALR 668
++ LE+ Q ++ R KLQREL++ T+ AM ++ + + R
Sbjct: 1876 KRQLEEAEEE--------AQRANASRRKLQRELEDATETADAMNREVSSLKNKLRR 1923
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 136 bits (343), Expect = 9e-32
Identities = 196/897 (21%), Positives = 379/897 (42%), Gaps = 106/897 (11%)
Query: 55 RQDEAEASMEALREAHQEELQNAVAETKARLLQEQGCAEEEALLQRIQALESALELQKRL 114
R+ E E + LR +EE + + +L +EQ E+ L +R Q L +L++
Sbjct: 353 REQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQL-RREQQLRREQQLRR-- 409
Query: 115 TEEALAESASCRLETKERELRVEAEHAERVLTLSREMLELKADYERRLQHLTSHEATPQG 174
E+ L R E + R + E H ++ RE LK + E R L E T
Sbjct: 410 -EQQLRREQQLRREQQLRREQEEERHEQKHEQERREQ-RLKREQEERRDWLKREEETE-- 465
Query: 175 RLPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYARKAEELQATYERENEAIRQ 234
R QE + + + Q E +E L+++ EE + ER + +R+
Sbjct: 466 RHEQERRKQQLKRDQEEERRERWLKLEE----------------EERREQQERREQQLRR 509
Query: 235 AMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEHRGRKISDLKKYAQKLK 294
++ Q L + QE+E L++ + ++ + Q + E L+ K + ++ Q+LK
Sbjct: 510 EQEERREQRLKR-QEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLK 568
Query: 295 ERIQDLDVQL---KEARQENSELKGTAKKLGEKLAVAKDRMMLQECRGTQQTDAMKTELV 351
++ QL +E R++ + ++L ++L + + QE R Q+ + E
Sbjct: 569 REQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEE 628
Query: 352 SENKVLREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEASAETEYMKQQYEEDLR 411
++L+ E E +++Q +E ++ ++E + +K+++EE+ R
Sbjct: 629 RRQQLLKSEEQEERRQQQLRREQQERRE-------QRLKREEEEERLEQRLKREHEEERR 681
Query: 412 KIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERKKLQREVEAQ-LEEVRK 470
+ + EEE++ ++++ R+ + E + +S V + +K + + Q EE R+
Sbjct: 682 E-QELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRR 740
Query: 471 KSEKEIKQLEEEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEESPQELGRQHCSILE 530
+ E E++ EEE+A + EE +++ T AEE E GRQ L
Sbjct: 741 RRESELQWQEEERAHRQQQ-----------EEEQRRDFTWQWQAEEK-SERGRQR---LS 785
Query: 531 TQDPCLKLDETSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLGSLLKEKTSK 590
+ P + E R EE Q + E+ +EEE+ + + +E+ +
Sbjct: 786 ARPPLREQRERQLRAEERQQR---EQRFLPEEEEKEQRRRQR------------REREKE 830
Query: 591 IQRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQRELQETTQ 650
+Q LEE+ Q Q+ + Q+ + + L++ R Q Q + E+ ++ + T
Sbjct: 831 LQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLY 890
Query: 651 QNHAMKAQLEASHQRALRMLEKARHQELKATEERLKKESSHSLQIQHQTHRLELQALEEK 710
A++ QL Q E+ + +E E+R ++E + + Q + E Q L E+
Sbjct: 891 AKPALQEQLRKEQQLLQEEEEELQREE---REKRRRQEQERQYREEEQLQQEEEQLLREE 947
Query: 711 ARQELQEERERMQAQQALLLESLRQELSEQQAACSGHQKDL-----EALQAELRALGRQQ 765
+ ++ERER + L + Q L E+ +++ E LQ E L R++
Sbjct: 948 REKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREE 1007
Query: 766 ASSQCPGD------SKDHIIATEERGGPGQAGSPPGAAGQGSGEGCGLWEENAQLQDAVR 819
+ + KD + EE+ + E +LQ+ R
Sbjct: 1008 REKRRRQEWERQYRKKDELQQEEEQLLREE-------------------REKRRLQERER 1048
Query: 820 RLRAEVEQHQQEAQKLRDQRRFLEETQQAQRAREVETLRQEHRKEMQAMVADFSSAQAQL 879
+ R E E Q+E Q L ++R + ++ R+ E L+QE E Q + + + Q
Sbjct: 1049 QYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQE---EEQLLREEPEKRRRQE 1105
Query: 880 QARLAALEAELKDSGE---KPGKGASRPEDLQLIGRLQTRL-KEREDIIKQLTEERR 932
+ R E EL+ E + + R ++L+ R + + +E E ++++ E+RR
Sbjct: 1106 RERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRR 1162
Score = 129 bits (325), Expect = 1e-29
Identities = 213/922 (23%), Positives = 370/922 (40%), Gaps = 139/922 (15%)
Query: 55 RQDEAEASMEALREAHQEELQNAVAETKARLLQEQG--CAEEEALLQRIQAL-------- 104
R+ E E E QEE Q E + R LQE+ EEE L Q + L
Sbjct: 1012 RRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETR 1071
Query: 105 -ESALELQKRLTEEALAESASC--------RLETKERELRVEAEHAERVLTLSREMLELK 155
LE Q R EE E R + +ER+ R E E + L RE E +
Sbjct: 1072 RRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKR 1131
Query: 156 ADYERRLQHLTSHEATPQG-RLPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDY 214
E Q+ E + +L +E PE + E++ E + L+ E +QL ++
Sbjct: 1132 RRQELERQYREEEEVQQEEEQLLREEPEKRRRQ----ELERQYREEEELQQEEEQLLREE 1187
Query: 215 ARKA-EELQATYERENEAIRQAMQQSV------SQALWQWQ-EKESDLRKNFQVQESALQ 266
K +E + Y E E RQ +Q S WQW+ EKE+ +R N +
Sbjct: 1188 QEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGREN 1247
Query: 267 AQVRKLEG----------DLEHR--GRKISDLKKYAQKLKERIQDLDVQLKEARQENSEL 314
Q R+LE DL+H ++ D ++ ++ ++R + + + R+E E
Sbjct: 1248 EQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEA 1307
Query: 315 KGTAKKLGEKLAVAKDRMMLQECRGTQQTDAM---KTELVSENK---VLREENDL---EA 365
K +K E+ + ++ +E R Q+TD + +L+ E + + R+E D E
Sbjct: 1308 KRRDRKSQEEKQLLREER--EEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREE 1365
Query: 366 GNLHPQQDQSCLKECPCMKGGTDMQT--KKEASAETEYMKQQYEEDL-RKIKHQTEEEKK 422
H +Q + L+E ++ + K+E + +QQ +D RK + + ++ +
Sbjct: 1366 ELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSR 1425
Query: 423 HLKDQLVKRLEDLVKKHTVEIKSVRSS--VEAERKKLQREVEAQLEEVRK----KSEKEI 476
+D+ + E V++ E K + + ER + RE E L+E + + E++
Sbjct: 1426 QERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDR 1485
Query: 477 KQLEEEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEESPQELGRQHCSILETQDPCL 536
K LEEE+ + E +E Q R EE ++ L+ +
Sbjct: 1486 KFLEEEQQLRRQERDRKFRE----QELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLR 1541
Query: 537 KLDETSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLGSLLKEKTSKIQRLEE 596
+ + R ++ K EE + EE+ L ++ D + L+E+ + Q E
Sbjct: 1542 RQERGQQRRQDRDRKFREEEQLRQEREEQQ--LSRQERDRK----FRLEEQKVRRQEQER 1595
Query: 597 DWQSQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSD--LEREKLQRELQETTQQNHA 654
+ + +L+ Q Q QQ ++ +RED Q L++ + L R++ R+ E Q
Sbjct: 1596 KFMEDEQQLRRQEGQ-QQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRR 1654
Query: 655 MKAQLEASHQRALR------MLEKARHQELKATEE-----------RLKKESSHSLQIQH 697
+ + + H R + +L++ Q+L+ E R ++ LQ +
Sbjct: 1655 QEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQ 1714
Query: 698 QTHRLELQAL---EEKARQELQEERERMQAQQALLLES--LRQELSEQQAACSGHQKDLE 752
Q R EL+ EE+ RQE ++E+ R Q + +LE LR E EQQ +++ +
Sbjct: 1715 QLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQL----RRQERD 1770
Query: 753 ALQAELRALGRQQASSQCPGDSKDHIIATEER---GGPGQAGSPPGAAGQGSGEGCGLWE 809
E L +++ Q D EE+ Q P G+ E E
Sbjct: 1771 RKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWE-----E 1825
Query: 810 ENAQLQDAVRRLRAEVEQH---------------------QQEAQKLRDQRR-------F 841
E QL++ +RLR E ++ Q+E QK R +R
Sbjct: 1826 EQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHI 1885
Query: 842 LEETQQAQRAREVETLRQEHRK 863
+ ++ QR R+V ++ + K
Sbjct: 1886 RRQQKEEQRHRQVGEIKSQEGK 1907
Score = 125 bits (315), Expect = 2e-28
Identities = 192/924 (20%), Positives = 380/924 (41%), Gaps = 125/924 (13%)
Query: 67 REAHQEELQNAVAETKARLLQEQGCAEEEALLQRIQALESALELQKRLTEEALAESASCR 126
R A +E+LQ+ E+ E L R + E + ++ + E
Sbjct: 186 RRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKE 245
Query: 127 LETKERELRVEAE-----HAERVLTLSREMLELKADYERRLQHLTSHEATPQGRLPQESP 181
+E LR E E +R L E +L+ + L+ E Q RL +E
Sbjct: 246 WRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQ 305
Query: 182 ETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYARKAEELQATYERENEAIRQAMQQSVS 241
+ + + E QE E Q R + ++ + R+ +E + RE + R+ ++
Sbjct: 306 LRRKQEEERREQQEERREQQERREQQEERREQQLRREQEER----REQQLRREQEEERRE 361
Query: 242 QALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEHRGRKISDLKKYAQKLKERIQDLD 301
Q L + QE+E ++ + Q+ + Q+R+ E + R+ L++ Q +E+ +
Sbjct: 362 QQLRREQEEERREQQLRREQQLRREQQLRR-----EQQLRREQQLRREQQLRREQQLRRE 416
Query: 302 VQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECRGTQQTDAMKTELVSENKVLREEN 361
QL+ +Q E + E+ K +E R ++ + + L E + R E
Sbjct: 417 QQLRREQQLRREQE-------EERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQ 469
Query: 362 DLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEEK 421
+ L Q++ + +K + + +++ E + ++Q E +++K Q EEE+
Sbjct: 470 ERRKQQLKRDQEEERRERW--LKLEEEERREQQERREQQLRREQEERREQRLKRQEEEER 527
Query: 422 --------KHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERKKLQREVEAQLEEVRKKSE 473
+ L+ + +R E L+K+ + R E ++L+RE E + +++ K+ E
Sbjct: 528 LQQRLRSEQQLRREQEERREQLLKRE----EEKRLEQERREQRLKREQEERRDQLLKREE 583
Query: 474 KEIKQL--EEEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEESPQELGRQHCSILET 531
+ +Q E++ L +L+ +E L EE +Q R E P+E RQ E
Sbjct: 584 ERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKR-----EEPEEERRQQLLKSEE 638
Query: 532 QDPCLKLDETSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLGSLLKEKT--- 588
Q+ + + E + +L EE EEER + LK + + L +E+
Sbjct: 639 QEERRQQQLRREQQERREQRLKREE-----EEERLEQRLKREHEEERREQELAEEEQEQA 693
Query: 589 -----SKIQRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDL---EREK 640
S+I + + +S+ Q++V + E ++ + ++ S+L E E+
Sbjct: 694 RERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEER 753
Query: 641 LQRELQETTQ------------------QNHAMKAQLEASHQRALRMLEKARHQELKATE 682
R+ QE Q Q + + L +R LR E+ + ++ E
Sbjct: 754 AHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPE 813
Query: 683 E-------RLKKESSHSLQIQHQTHRLELQALEEKARQE---LQEERERMQAQQALLLES 732
E R ++E LQ + +L+ + ++ ++E LQE++ER ++Q+ +
Sbjct: 814 EEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQK 873
Query: 733 LRQELSEQQAACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGS 792
R +L E++ ALQ +LR ++Q Q ++ + EER
Sbjct: 874 WRWQLEEERKRRRHTLYAKPALQEQLR---KEQQLLQ----EEEEELQREER-------- 918
Query: 793 PPGAAGQGSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRAR 852
E + Q+ R+ R E + Q+E Q LR++R E+ ++ +R R
Sbjct: 919 -----------------EKRRRQEQERQYREEEQLQQEEEQLLREER---EKRRRQERER 958
Query: 853 EVETLRQEHRKEMQAMVADFSSAQAQLQARLAALEAELKDSGE---KPGKGASRPEDLQL 909
+ ++ +KE Q + + + Q + + E EL+ E + + R ++ +
Sbjct: 959 QYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWER 1018
Query: 910 IGRLQTRL-KEREDIIKQLTEERR 932
R + L +E E ++++ E+RR
Sbjct: 1019 QYRKKDELQQEEEQLLREEREKRR 1042
Score = 122 bits (306), Expect = 2e-27
Identities = 209/943 (22%), Positives = 387/943 (41%), Gaps = 140/943 (14%)
Query: 67 REAHQEELQNAVAETKARLLQEQGCAEEEALLQRIQALESALELQKRLTEEALAESASCR 126
+E +++L+ E + + L+ Q EEE L QR+++ + Q+ E+ L R
Sbjct: 500 QERREQQLRREQEERREQRLKRQ--EEEERLQQRLRSEQQLRREQEERREQLLKREEEKR 557
Query: 127 LETKERELRVEAEHAERVLTL-----SREMLELKADYERRLQHLTSHEATP--------Q 173
LE + RE R++ E ER L R LK + E RL+ E +
Sbjct: 558 LEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERRE 617
Query: 174 GRLPQESPET-------KSEPGQGPEMQEVLLEVQRLRVENQQLSKDYARKAEELQATYE 226
RL +E PE KSE + Q++ E Q R + + ++ R + L+ +E
Sbjct: 618 QRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHE 677
Query: 227 ---RENEAIRQAMQQSVSQAL-----WQWQ-EKESDLRKNFQVQESALQAQVRKLEGDLE 277
RE E + +Q+ + WQWQ E E+D R++ Q R+ + E
Sbjct: 678 EERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEE 737
Query: 278 HRGRKISDLKKYAQKLKERIQDLDVQLKE-----ARQENSELKGTAKKLGEKLAVAKDRM 332
R R+ S+L+ ++ R Q + Q ++ +E SE L ++R
Sbjct: 738 KRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQ 797
Query: 333 MLQECRGTQQTDAMKTELVSENKVLREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTK 392
+ E R + E + L EE + E ++ + KE ++ +Q +
Sbjct: 798 LRAEERQQR-----------EQRFLPEEEEKEQRRRQRRERE---KELQFLEEEEQLQ-R 842
Query: 393 KEASAETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEA 452
+E + + + + +ED + + Q + + + QL + E ++HT+ K
Sbjct: 843 RERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEE--ERKRRRHTLYAKPALQEQLR 900
Query: 453 ERKKLQREVEAQLEEVRKKSEKEIKQLEEEKAALNVKLQNSLLEVLRLEEFIQQNKTRPT 512
+ ++L +E E +L+ R++ EK +Q +E + +LQ ++LR E ++ + R
Sbjct: 901 KEQQLLQEEEEELQ--REEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQER-- 956
Query: 513 GAEESPQELGRQHCSILETQDPCLKLDETSPRGEEYQDKLAAEEGTSSDEEERTKVLLKE 572
+ R+ + + ++ L + R +E + K EE +EE+
Sbjct: 957 ------ERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQ-------- 1002
Query: 573 GSDPQPPLGSLLKEKTSKIQRLEEDWQSQ---KAKLQAQVSQM------QQALEQCTSNY 623
LL+E+ K +R ++W+ Q K +LQ + Q+ ++ L++ Y
Sbjct: 1003 ----------LLREEREKRRR--QEWERQYRKKDELQQEEEQLLREEREKRRLQERERQY 1050
Query: 624 REDLQALKQLSDLEREKLQRELQETTQQNHAMKAQLEASHQRALRML-EKARHQELKAT- 681
RE+ + ++ L E+ + ++ ++ + + +L+ ++ LR EK R QE +
Sbjct: 1051 REEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQC 1110
Query: 682 --EERLKKESSHSLQIQHQTHR---LELQALEEKA---------RQELQEERERMQAQQA 727
EE L++E L+ + + R LE Q EE+ R+E ++ R + +Q
Sbjct: 1111 REEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQY 1170
Query: 728 LLLESLRQELSEQQAACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIATEERGGP 787
E L+QE E+Q +K + + + R Q + K ++R
Sbjct: 1171 REEEELQQE--EEQLLREEQEKRRQERERQYREEEELQRQKR-----KQRYRDEDQRSDL 1223
Query: 788 GQAGSPPGAAGQGSGEGCGLWEENAQLQDAVRRLRAEVEQHQQ-EAQKLRDQRRFLEETQ 846
P +ENA + V E EQ +Q E +LRD++ ++
Sbjct: 1224 KWQWEPE--------------KENAVRDNKVYCKGRENEQFRQLEDSQLRDRQS--QQDL 1267
Query: 847 QAQRAREVETLRQEHRKEMQAMVADFSSAQAQLQARLAALEAELKDSGEKPGKGASRPED 906
Q + E R++ R+ Q F + QL+ R EA+ +D + K R E
Sbjct: 1268 QHLLGEQQERDREQERRRWQQRDRHFPE-EEQLE-REEQKEAKRRDRKSQEEKQLLREER 1325
Query: 907 LQLIGRLQTRLKEREDIIKQLTEERRFHYAAFPSAMSHRNRSF 949
+ R +T K RE+ +QL +ER P R+R F
Sbjct: 1326 EEKRRRQETDRKFREE--EQLLQEREEQ----PLRRQERDRKF 1362
Score = 121 bits (303), Expect = 4e-27
Identities = 183/801 (22%), Positives = 332/801 (41%), Gaps = 97/801 (12%)
Query: 178 QESPETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYARKAEELQATYERENEAIRQAMQ 237
QE + + EP +E QR R + Q+ ++ A + EE ER + RQ
Sbjct: 115 QEEDQRRFEPRDRQLEEE---PGQRRRQKRQEQERELA-EGEEQSEKQERLEQRDRQRRD 170
Query: 238 QSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEHRGRKISDLKKYAQKLKERI 297
+ + + +WQE+E + Q+Q S + + + + R R++ +L++ ++ K+
Sbjct: 171 EELWRQRQEWQEREERRAEEEQLQ-SCKGHETEEFPDEEQLRRRELLELRRKGREEKQ-- 227
Query: 298 QDLDVQLKEARQENSELKGTAKKLGEKLAV-AKDRMMLQECRGTQQTDAMKTELVSENKV 356
Q + RQ+ + K+ ++ V K+ LQE + + EL E +
Sbjct: 228 -----QQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQE-----EEPQRQRELQEEEEQ 277
Query: 357 LR--EENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEASAETEYMKQQYEEDLRKIK 414
LR E +L +Q Q L+ + Q +++ E +++ E + +
Sbjct: 278 LRKLERQELRRERQEEEQQQQRLRR--------EQQLRRKQEEERREQQEERREQQERRE 329
Query: 415 HQTEEEKKHLKDQLVKRLEDLVKKHTVEIK---SVRSSVEAERKKLQREVEAQLEEVRKK 471
Q E ++ L+ + +R E +++ E + +R E ER++ Q E QL R++
Sbjct: 330 QQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLR--REQ 387
Query: 472 SEKEIKQLEEEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEESPQELGRQHCSILET 531
+ +QL E+ + ++ R ++ ++ + R EE ++ Q E
Sbjct: 388 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQ-----ER 442
Query: 532 QDPCLKLDETSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLGSLLKE----- 586
++ LK ++ EE +D L EE T E+ER K LK + + L E
Sbjct: 443 REQRLKREQ-----EERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERR 497
Query: 587 -----KTSKIQRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKL 641
+ +++R +E+ + Q+ K Q + ++QQ L RE + +QL L+RE+
Sbjct: 498 EQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQL--LKREEE 555
Query: 642 QRELQETTQQNHAMKAQLEASHQRALRMLEKARHQELK-----ATEERLKKESSHSL-QI 695
+R QE +Q +K + E + L+ E+ R Q LK E+RLK+E L Q
Sbjct: 556 KRLEQERREQR--LKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQE 613
Query: 696 QHQTHRLELQALEEKARQEL-----QEERERMQ--------AQQALLLESLRQELSEQQA 742
+ + RL+ + EE+ RQ+L QEER + Q +Q L E + L ++
Sbjct: 614 ERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLK 673
Query: 743 ACSGHQKDLEALQAELRALGRQQASSQCP---------GDSKDHIIATEERGGPGQAGSP 793
++ + L E + R++ S+ P D++ + + R GQ
Sbjct: 674 REHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQ 733
Query: 794 PGAAGQGSGEGCGLW--EENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRA 851
+ E W EE A Q R + Q +K R+ L +
Sbjct: 734 EQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQ 793
Query: 852 REVETLRQEHRKEMQAMVADFSSAQAQLQARLAALEAELKDSGEKPGKGASRPEDLQLIG 911
RE LR E R++ + + Q + + E EL+ E+ E LQ
Sbjct: 794 RE-RQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEE--------EQLQRRE 844
Query: 912 RLQTRLKEREDIIKQLTEERR 932
R Q +L+E ED +++ E RR
Sbjct: 845 RAQ-QLQEEEDGLQEDQERRR 864
Score = 112 bits (279), Expect = 2e-24
Identities = 197/938 (21%), Positives = 373/938 (39%), Gaps = 133/938 (14%)
Query: 52 LNTRQDEAEASMEALREAHQEELQNAVAETKARLLQEQGCAEEEALLQRIQALESALELQ 111
L + E E + L+ QEE + + + +EQ EE + Q L+ E +
Sbjct: 620 LKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEE 679
Query: 112 KRLTEEALAESASCRLETKER------ELRVEAEHAERVLTLSREMLELKADYERRLQHL 165
+R E A E R K R +L EA+ A + SR K + +RR Q
Sbjct: 680 RREQELAEEEQEQARERIKSRIPKWQWQLESEAD-ARQSKVYSRPR---KQEGQRRRQEQ 735
Query: 166 TSHEATPQGRLPQESPETKSEPGQGPEMQ-----EVLLEVQRLRVENQQLSKDYARKAEE 220
+ L + E Q E + + E + R + ++ R+ E
Sbjct: 736 EEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRE 795
Query: 221 LQATYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEHRG 280
Q E + ++ + + + + Q +E + F +E LQ + R + E G
Sbjct: 796 RQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDG 855
Query: 281 RKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQ-ECRG 339
+ ++ +Q+ + R Q QL+E R+ L E+L K++ +LQ E
Sbjct: 856 LQEDQERRRSQE-QRRDQKWRWQLEEERKRRRHTLYAKPALQEQL--RKEQQLLQEEEEE 912
Query: 340 TQQTDAMKTELVSENKVLREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEASAET 399
Q+ + K + + REE L+ Q+++ L+E + + ++ E
Sbjct: 913 LQREEREKRRRQEQERQYREEEQLQ------QEEEQLLRE--------EREKRRRQERER 958
Query: 400 EYMK----QQYEEDL-----RKIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSV 450
+Y K QQ EE L K + Q E+K +++L + E L++ E + R
Sbjct: 959 QYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLR----EEREKRRRQ 1014
Query: 451 EAERKKLQREVEAQLEEVRKKSEKEIKQLEEEKAALNVKLQNSLLEVLRLEEFIQQNKTR 510
E ER+ +++ Q EE + E+E ++L+E + R EE +QQ + +
Sbjct: 1015 EWERQYRKKDELQQEEEQLLREEREKRRLQERE------------RQYREEEELQQEEEQ 1062
Query: 511 PTGAEESP---QELGRQHC--SILETQDPCLKLDETSPRGEEYQDKLAAEEGTSSDEEER 565
G E QEL RQ+ L+ ++ L +E R + +++ EE EEE+
Sbjct: 1063 LLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQ 1122
Query: 566 -------------TKVLLKEGSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQM 612
+ +E + Q LL+E+ K +R E + Q ++ + + Q +
Sbjct: 1123 LLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEE-ELQQEEE 1181
Query: 613 QQALEQCTSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMKAQLEASHQRALR---- 668
Q E+ +E + ++ +L+R+K ++ ++ Q++ +K Q E + A+R
Sbjct: 1182 QLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSD-LKWQWEPEKENAVRDNKV 1240
Query: 669 MLEKARHQELKATEERLKKESSHSLQIQHQTHRLELQALEEKARQELQEERERMQAQQAL 728
+ +++ + E+ ++ +QH L E+ ++ ++ER R Q +
Sbjct: 1241 YCKGRENEQFRQLEDSQLRDRQSQQDLQH--------LLGEQQERDREQERRRWQQRDRH 1292
Query: 729 LLESLRQELSEQQAACSGHQKDLEALQ--AELRALGRQQASSQCPGDSKDHIIATEERGG 786
E + E EQ+ A +K E Q E R R++ + ++ ++ E
Sbjct: 1293 FPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQERE--- 1349
Query: 787 PGQAGSPPGAAGQGSGEGCGLWEENAQLQDAVRRLRAEVEQHQ-------QEAQKLRDQ- 838
E+ + Q+ R+ R E +HQ +E Q+LR Q
Sbjct: 1350 ----------------------EQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQE 1387
Query: 839 --RRFLEETQQAQRAREVETLRQEHRKEMQAMVADFSSAQAQLQARLAALEAELKDSGEK 896
R+FL+E QQ + + LRQ+ ++ + Q Q R E + +
Sbjct: 1388 RERKFLKEEQQLRCQEREQQLRQDRDRKFRE-----EEQQLSRQERDRKFREEEQQVRRQ 1442
Query: 897 PGKGASRPEDLQLIGRLQTRLKEREDIIKQLTEERRFH 934
+ E+ QL + +E E ++++ EE++ H
Sbjct: 1443 ERERKFLEEEQQLRQERHRKFREEEQLLQE-REEQQLH 1479
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 134 bits (338), Expect = 3e-31
Identities = 226/982 (23%), Positives = 394/982 (40%), Gaps = 137/982 (13%)
Query: 41 KIAQLTKVIYALNTRQDEAEASMEALREAHQEELQNAVAE-------TKARLLQEQGCAE 93
K+ LT+ + AL+ +AL+EAHQ+ L + AE TKA+L EQ +
Sbjct: 1023 KVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVED 1082
Query: 94 EEALLQRIQALESALELQKR-------LTEEALAESASCRLETKERELRVEAEHAERVLT 146
E L++ + L E KR LT+E++A++A + + +E+ + ++E ++ L
Sbjct: 1083 LECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLR 1142
Query: 147 LSREMLELKADYERRLQHLTSHEATPQGRLPQESPETKSEPGQGPEMQEVLLEVQRLRVE 206
+ E L L A +++++ L + + L E Q E L E+ E
Sbjct: 1143 VEDEQL-LGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEE 1201
Query: 207 NQQLS---KDYARKAEELQATYERE-------NEAIRQAMQQSVSQALWQWQEKESDL-- 254
S ++ RK E RE +EA A+++ ++ + E+ L
Sbjct: 1202 AGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQR 1261
Query: 255 -RKNFQVQESALQAQVRKLEGDLEHRGRKISDLKK----YAQKLKE---RIQDLDVQLKE 306
R+ + ++S L+ +V L ++E R + +K Y +L E ++++L QL +
Sbjct: 1262 VRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLAD 1321
Query: 307 ARQENSELKGTAKKLGEKLAVAKDRMMLQECRGTQQTDAMKTELVSENKVLREENDLEAG 366
A + L+ + +L +L K+ ++ Q RG EL + L EE+ ++
Sbjct: 1322 ASTQRGRLQTESGELS-RLLEEKECLISQLSRGKALAAQSLEEL---RRQLEEESKAKSA 1377
Query: 367 NLHPQQ----DQSCLKECPCMKGGTDMQTKK---EASAETEYMKQQYEEDLRKIKHQTEE 419
H Q D L+E + + ++ +A+AE + +YE D + + EE
Sbjct: 1378 LAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEE 1437
Query: 420 EKKHLKDQLVK--------------------RLEDLVKKHTVEIKSVRSSVEAERKKLQR 459
KK L +L + RL+ + T+E++ S+ A KK QR
Sbjct: 1438 AKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKK-QR 1496
Query: 460 EVEAQLEEVRKKSE---KEIKQLEEEKAALNV---KLQNSLLEVLR-LEEFIQQNKTRPT 512
+E LEE R++ E +E++ + E L +L++ E L LE ++NK
Sbjct: 1497 HLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQE 1556
Query: 513 GAEESPQELGRQHCSILETQDPCLKLDETSPRGEEYQDKLAAEEGTSSDEEERTKVLLKE 572
+ ++ SI E L+ + + GE+ + + A EE + E E TK L
Sbjct: 1557 EISDLTDQVSLSGKSIQE-----LEKTKKALEGEKSEIQAALEEAEGALELEETKTLRI- 1610
Query: 573 GSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQALKQ 632
Q L + E K+ +E+ + + Q V +Q +L+ T E L+ K+
Sbjct: 1611 ----QLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKK 1666
Query: 633 ----LSDLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLEKARHQELKATEERLKKE 688
L+DLE Q HA + EA L + Q + E+RL E
Sbjct: 1667 MEGDLNDLE-----------LQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAE 1715
Query: 689 SSHSLQIQHQTHRLELQALEEKARQELQEERERMQAQQALLLESLRQE-LSEQQAACSGH 747
Q + L LEE Q ER R A+Q LL + R L Q
Sbjct: 1716 LHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQ 1775
Query: 748 QKDLEALQAELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGAAGQGSGEGCGL 807
+K LEA A+L + A + + K T+ A + L
Sbjct: 1776 KKKLEADLAQLSGEVEEAAQERREAEEKAKKAITD-------AAMMAEELKKEQDTSAHL 1828
Query: 808 WEENAQLQDAVRRLRAEVEQHQQEA--------QKLRDQRRFLEETQQAQRAREVETLRQ 859
L+ VR L+A +E+ +Q A QKL + R LE A++ + E L+
Sbjct: 1829 ERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKG 1888
Query: 860 EHRKEMQAMVADFSSAQAQLQARLAALEAELKDSGEKPGKGASRPEDLQLIGRLQTRLKE 919
+ E + EL E+ K +R +D L+ +LQ+++K
Sbjct: 1889 VRKHERRV--------------------KELAYQAEEDRKNLARMQD--LVDKLQSKVKS 1926
Query: 920 REDIIKQLTEERRFHYAAFPSA 941
+ ++ ++ + A + A
Sbjct: 1927 YKRQFEEAEQQANTNLAKYRKA 1948
Score = 122 bits (307), Expect = 1e-27
Identities = 195/872 (22%), Positives = 383/872 (43%), Gaps = 103/872 (11%)
Query: 97 LLQRIQALE--SALELQKRLTEEALAESASCRLETKERELRVEAEHAERVLTLSREMLEL 154
LL+ QA E +AL + R ALA + + R E +E + + E + L L E L
Sbjct: 888 LLRSAQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNL 947
Query: 155 KADYERRLQHLTSHEATPQGRLPQESPETKSEPGQGPEMQEVLLEVQRLRVENQ--QLSK 212
AD E R L + +G++ + S + E E L +R ++E++ +L K
Sbjct: 948 -ADAEERCHLLIKSKVQLEGKVKELSERLEDE-----EEVNADLAARRRKLEDECTELKK 1001
Query: 213 DYARKAEELQATY---ERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQV 269
D ++L+ T E+E +A ++ ++++ + E + L K ++ ALQ
Sbjct: 1002 DI----DDLKLTLAKAEKEKQATENKVK-NLTEEMAALDESVARLTK----EKKALQEAH 1052
Query: 270 RKLEGDLEHRGRKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAK 329
++ GDL+ ++S L K +L+++++DL+ L++ ++ + + +KL L + +
Sbjct: 1053 QQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQ 1112
Query: 330 DRMMLQECRGTQQTDAMKTELVSENKVLREENDLEAGNLHPQ-------QDQSCLKECPC 382
+ + DA + + E K+ +++++L +L + Q Q +KE
Sbjct: 1113 ESV----------ADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQA 1162
Query: 383 MKGGTDMQTKKEASAETEYMKQQYE--EDLRKIKHQTEE-------------EKKHLKDQ 427
+ + + E +A KQ+ E +L ++ + EE +++ +
Sbjct: 1163 RAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGR 1222
Query: 428 LVKRLEDLVKKHTVEIKSVRSSVEAERKKLQREVEAQLEEVRKKSEKEIKQLEEEKAALN 487
L + LE+ +H + ++R +L +V++ L+ VR+K EKE +L E L
Sbjct: 1223 LRRELEEAALRHEATVAALRRKQAEGAAELGEQVDS-LQRVRQKLEKEKSELRMEVDDLA 1281
Query: 488 VKLQNSLLEVLRLEEFIQQNKTRPTGAEESPQELGRQHCSILETQDPCLKLD--ETSPRG 545
++ E+ + + + + A+ +EL RQ + TQ L+ + E S
Sbjct: 1282 ANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQ-LADASTQRGRLQTESGELSRLL 1340
Query: 546 EEYQ---DKLAAEEGTSSDEEERTKVLLKEGSDPQPPLG---SLLKEKTSKIQRLEEDWQ 599
EE + +L+ + ++ E + L+E S + L L+ ++ E+
Sbjct: 1341 EEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEA 1400
Query: 600 SQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLE--REKLQRELQETTQQNHAMKA 657
+A+LQ +S+ + Q S Y D A+++ +LE ++KL LQE + A A
Sbjct: 1401 EAQAELQRLLSKANAEVAQWRSKYEAD--AIQRTEELEEAKKKLALRLQEAEEGVEAANA 1458
Query: 658 QLEASHQRALRMLEKARHQELKATEERLKKESSHSLQIQHQTHRLELQALEEKARQELQE 717
+ + + LR+ ++ L+ L++ +S + + + LE +ALEE+ RQE +
Sbjct: 1459 KCSSLEKAKLRLQTESEDVTLE-----LERATSAAAALDKKQRHLE-RALEERRRQEEEM 1512
Query: 718 ERERMQAQQALLLESLRQELSEQQAACSGHQKDLEALQAELRALGRQQASSQCPGDSKDH 777
+RE AQ+ L EL + GH++ LEAL+ L R+ + Q
Sbjct: 1513 QRELEAAQRE--SRGLGTELFRLR---HGHEEALEALE----TLKRENKNLQEEISDLTD 1563
Query: 778 IIATEERGGPGQAGSPPGAAGQGSGEGCGLWEENAQLQ-DAVRRLRAEVEQHQQEAQKLR 836
++ + + G+ S L E L+ + + LR ++E Q +A+
Sbjct: 1564 QVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAE--- 1620
Query: 837 DQRRFLEETQQAQRAREVETLRQEHRKEMQAMVADFSSAQAQLQARLAAL------EAEL 890
+ + A++ E LR+ H++ ++++ A S A+ +AR AL E +L
Sbjct: 1621 ------VDRKLAEKDEECANLRRNHQRAVESLQA---SLDAETRARNEALRLKKKMEGDL 1671
Query: 891 KDSGEKPGKGASRPEDLQLIGRL-QTRLKERE 921
D + G + + Q RL Q +LKE +
Sbjct: 1672 NDLELQLGHATRQATEAQAATRLMQAQLKEEQ 1703
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 131 bits (329), Expect = 4e-30
Identities = 219/986 (22%), Positives = 431/986 (43%), Gaps = 145/986 (14%)
Query: 41 KIAQLTKVIYALNTRQDEAEASMEALREAHQEELQNAVAET-KARLLQEQGCAEEEALLQ 99
K+ LT+ + L+ + +AL+EAHQ+ L + AE K L + + L Q
Sbjct: 975 KVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKT----KSKLEQ 1030
Query: 100 RIQALESALELQKRLTEEALAESASCRLETKERELRVEAEHA-ERVLTLSREMLEL---- 154
+++ LES+LE +K+L + LE +R+L + + A E +L L + +L
Sbjct: 1031 QVEDLESSLEQEKKLRVD---------LERNKRKLEGDLKLAQESILDLENDKQQLDERL 1081
Query: 155 -KADYER-RLQHLTSHEATPQGRLPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLSK 212
K D+E +LQ E T + ++ E ++ + E++E + + R + ++
Sbjct: 1082 KKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQA---RIEELEEEIEAERATRAKTEKQRS 1138
Query: 213 DYARKAEEL-------------QATYERENEAIRQAMQQSVSQALWQWQEKESDLRK--- 256
DYAR+ EEL Q ++ EA +++ + +A Q + + LRK
Sbjct: 1139 DYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHA 1198
Query: 257 -----------NFQVQESALQAQVRKLEGDLEHRGRKISDLKKYAQKLKERIQDLDVQLK 305
N Q + L+ + + + +++ + + K L++ + L+ QL
Sbjct: 1199 DSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLS 1258
Query: 306 EARQENSELKGTAKKL-----------GE--KLAVAKDRMMLQECRG----TQQTDAMKT 348
EAR +N E++ + +L GE + K+ ++ Q R TQQT+ +K
Sbjct: 1259 EARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKR 1318
Query: 349 ELVSENKVLREENDLEAGNLHPQQDQSCLKEC--PCMKGGTDMQ-TKKEASAETEYMKQQ 405
+L ENK +N L + D L+E +G ++Q +A++E + +
Sbjct: 1319 QLEEENKA---KNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTK 1375
Query: 406 YEEDLRKIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERKKLQREVEAQL 465
YE D + + EE KK +L +RL+D ++ + + +S+E +++LQ EVE +
Sbjct: 1376 YETDAIQRTEELEEAKK----KLAQRLQD-SEEQVEAVNAKCASLEKTKQRLQGEVEDLM 1430
Query: 466 EEVRKKS------EKEIKQLEEEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEESPQ 519
+V + + +K+ + ++ A K + S E LE ++++++ T
Sbjct: 1431 VDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAE---LEASLKESRSLST------- 1480
Query: 520 ELGRQHCSILETQDPCLKLDETSPRGEEYQDKLA------AEEGTSSDEEERTKVLLK-E 572
EL + + E D +L+ + + ++A AE G + E E+++ ++ E
Sbjct: 1481 ELFKLKNAYEEALD---QLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELE 1537
Query: 573 GSDPQPPL---GSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQA 629
+D Q L + L+ + +KI R++ + K+++ ++++ + +EQ NY+ ++
Sbjct: 1538 KADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVET 1597
Query: 630 LKQLSDLE---REKLQRELQETTQQNHAMKAQLEASHQRALRMLEKAR--HQELKATEER 684
++ D E R + R ++ + ++ QL ++++A L+ R +LK T+
Sbjct: 1598 MQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLH 1657
Query: 685 LKKESSHSLQIQHQTHRLE-----LQALEEKARQEL-QEERERMQAQQALLLESLRQELS 738
L ++ Q +E LQA E+ R L Q ER R A+Q LL + R +L
Sbjct: 1658 LDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLL 1717
Query: 739 EQQAACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGAAG 798
Q H K + L+ +L Q S+ S+D A E+ A
Sbjct: 1718 HTQNTSLIHTK--KKLETDL-----MQLQSEVEDASRDARNAEEK-------------AK 1757
Query: 799 QGSGEGCGLWEENAQLQDA---VRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRAREVE 855
+ + + EE + QD + R++ +EQ ++ Q D+ L ++ +++E
Sbjct: 1758 KAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLE 1817
Query: 856 TLRQEHRKEMQAMVADFSSAQAQLQARLAALEAELKDSGEKPGKGASRPEDLQLIGRLQT 915
T +E E++ + + L+ + EL E+ K R +D L+ +LQ
Sbjct: 1818 TRIRELEFELEGEQKKNTESVKGLR-KYERRVKELTYQSEEDRKNVLRLQD--LVDKLQV 1874
Query: 916 RLKEREDIIKQLTEERRFHYAAFPSA 941
++K + ++ E+ H F A
Sbjct: 1875 KVKSYKRQAEEADEQANAHLTKFRKA 1900
Score = 105 bits (263), Expect = 2e-22
Identities = 170/813 (20%), Positives = 345/813 (42%), Gaps = 72/813 (8%)
Query: 109 ELQKRLTEEALAESASCRLETKERELRVEAEHAERVLTLSREMLELKADYERRLQHLTSH 168
E QK T++ LA+S + R E +E+ + + E + L + E L D E R L
Sbjct: 856 EFQK--TKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENL-LDAEERCDQLIKA 912
Query: 169 EATPQGRLPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYARKAEELQATYERE 228
+ + ++ + + + E E+ + ++L E +L KD E A E+E
Sbjct: 913 KFQLEAKIKEVTERAEDEEEINAELTA---KKRKLEDECSELKKDID-DLELTLAKVEKE 968
Query: 229 NEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEHRGRKISDLKK 288
A ++ ++++ L E + L + ++ ALQ ++ DL+ K++ L K
Sbjct: 969 KHATENKVK-NLTEELSGLDETIAKLTR----EKKALQEAHQQALDDLQAEEDKVNSLNK 1023
Query: 289 YAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECRGTQQTDAMKT 348
KL+++++DL+ L++ ++ +L+ +KL L +A++ ++ E Q + +K
Sbjct: 1024 TKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKK 1083
Query: 349 ELVSENKVLREENDLEAGNLHPQQDQSCLKECPCM--KGGTDMQTKKEASAETEYMKQQY 406
+ ++ + D + L Q Q +KE + +++ ++ A+TE + Y
Sbjct: 1084 KDFEYCQLQSKVEDEQTLGL---QFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDY 1140
Query: 407 EEDLRKIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERKKLQREVEAQLE 466
+L ++ + EE Q+ +L KK E +R +E + + EA +
Sbjct: 1141 ARELEELSERLEEAGGVTSTQI-----ELNKKREAEFLKLRRDLE----EATLQHEAMVA 1191
Query: 467 EVRKKSEKEIKQLEEEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEESPQELGRQHC 526
+RKK + +L E+ L Q E + I + +S L + C
Sbjct: 1192 ALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANL-EKIC 1250
Query: 527 SILETQDPCLKLDETSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLGSLLKE 586
LE Q L E + EE Q L+ S + L ++ + + + L +
Sbjct: 1251 RTLEDQ-----LSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRS 1305
Query: 587 KTSKIQRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLERE---KLQR 643
K + Q+ EE K +L+ + ++ + AL + R D L++ + E+E +LQR
Sbjct: 1306 KQAFTQQTEE----LKRQLEEE-NKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQR 1360
Query: 644 ELQETTQQNHAMKAQLEASHQRALRMLEKARH---QELKATEERLKKESSHSLQIQHQTH 700
L + + + + E + LE+A+ Q L+ +EE+++ ++ ++
Sbjct: 1361 ALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQ 1420
Query: 701 RLELQALEEKARQELQEERERMQAQQALLLESLR---QELSEQQAACSGHQKDLEALQAE 757
RL+ + ++L + ER + A L + R + L+E + C Q +LEA E
Sbjct: 1421 RLQGEV------EDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKE 1474
Query: 758 LRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGAAGQGSGEGCGLWE-------- 809
R+L + + + + T +R Q + G + E
Sbjct: 1475 SRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQI 1534
Query: 810 --ENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLE-----ETQQAQRAREVETLRQEHR 862
E A +Q A+ A +E +EA+ LR Q + + + A++ E+E L++ ++
Sbjct: 1535 ELEKADIQLALEEAEAALE--HEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQ 1592
Query: 863 KEMQAMVADFSSAQAQLQARLAALEAELKDSGE 895
+ ++ M S+ A++++R A+ + K G+
Sbjct: 1593 RTVETMQ---SALDAEVRSRNEAIRLKKKMEGD 1622
Score = 76.6 bits (187), Expect = 1e-13
Identities = 119/502 (23%), Positives = 216/502 (43%), Gaps = 97/502 (19%)
Query: 40 KKIAQLTKVIYALNTRQDEAEASMEA--------------LREAHQEEL--------QNA 77
KK KV+ T+ +E++A +EA L+ A++E L +N
Sbjct: 1445 KKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENK 1504
Query: 78 VAETKARLLQEQGCAEEEALLQRIQALESALELQKRLTEEALAESASCRLETKEREL--- 134
E + L EQ AE + ++ +EL+K + AL E A LE +E ++
Sbjct: 1505 NLEQEIADLTEQ-IAENGKTIHELEKSRKQIELEKADIQLAL-EEAEAALEHEEAKILRI 1562
Query: 135 -----RVEAEHAERVLTLSREMLELKADYERRLQHLTSHEATPQGRLPQESPETKSEPGQ 189
+V++E ++ E+ +LK +Y+R ++ T Q L E
Sbjct: 1563 QLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVE-------TMQSALDAEVRSRNEAIRL 1615
Query: 190 GPEMQEVLLEVQRLRVENQQLSKDYARKAEELQATYERENEAIRQAMQQSVSQALWQWQE 249
+M+ L E++ QLS + AE L+ + R + + Q + AL
Sbjct: 1616 KKKMEGDLNEIE------IQLSHANRQAAETLK--HLRSVQGQLKDTQLHLDDAL----R 1663
Query: 250 KESDLRKNFQVQE---SALQAQVRKLEGDLE--HRGRKISD------------------- 285
+ DL++ + E + LQA+V +L LE R RK+++
Sbjct: 1664 GQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTS 1723
Query: 286 LKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECRGTQQTDA 345
L +KL+ + L ++++A ++ + AKK A+ MM +E + Q T A
Sbjct: 1724 LIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKK-----AITDAAMMAEELKKEQDTSA 1778
Query: 346 ----MKTELVSENKVLREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEASAETEY 401
MK L K L+ D EA L + + +++ + + + E TE
Sbjct: 1779 HLERMKKNLEQTVKDLQHRLD-EAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTES 1837
Query: 402 MK--QQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERKKLQR 459
+K ++YE ++++ +Q+EE++K+ V RL+DLV K V++KS + E +
Sbjct: 1838 VKGLRKYERRVKELTYQSEEDRKN-----VLRLQDLVDKLQVKVKSYKRQAE----EADE 1888
Query: 460 EVEAQLEEVRKKSEKEIKQLEE 481
+ A L + R K++ E+++ EE
Sbjct: 1889 QANAHLTKFR-KAQHELEEAEE 1909
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 130 bits (326), Expect = 9e-30
Identities = 211/915 (23%), Positives = 394/915 (43%), Gaps = 120/915 (13%)
Query: 74 LQNAVAETKARLLQEQGCAEEEALLQRIQALESALELQKRLTEEALAESAS----CRLET 129
LQ A+ E + + EQ AE + L+R + ++ + + E ALA LE
Sbjct: 353 LQEALKEKQQHI--EQLLAERD--LERAEVAKATSHVGEIEQELALARDGHDQHVLELEA 408
Query: 130 KERELRVEAEHAERVLTLSREMLELKADYERRLQHLTSHEATPQGRLPQESPETKSEPGQ 189
K +LR E A+R LE + LQ E+ +G L +TK E +
Sbjct: 409 KMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDL---ETQTKLEHAR 465
Query: 190 GPEMQEVLL-----------EVQRLRVEN-------QQLSKDYARKAEELQATYERENEA 231
E+++ LL E++ RV +L KD A + +E+ A R E+
Sbjct: 466 IKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEV-AELRRRLES 524
Query: 232 IRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEHRG-------RKIS 284
+ A +S +L Q + S L++ +V + Q ++ L+ EH G ++I
Sbjct: 525 NKPAGDVDMSLSLLQ---EISSLQEKLEVTRTDHQREITSLK---EHFGAREETHQKEIK 578
Query: 285 DLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECR-----G 339
L +KL + + L +L+ A +ENS++ K E A+A + ++E + G
Sbjct: 579 ALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLET-AIASHQQAMEELKVSFSKG 637
Query: 340 TQQTDAMKTELVSENKVLREENDLEAGNLHPQQDQ---SCLKECPCMKGGTDMQTK-KEA 395
A EL ++ + +R + E NL QQD + KE ++ K KE
Sbjct: 638 LGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKEN 697
Query: 396 SAETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDLVKK---HTVEIKSVRSSVEA 452
S E K ED ++ + K + VK LE L K T I + S ++A
Sbjct: 698 SLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKA 757
Query: 453 ERKKL---------QREVEAQLEEVRKK---SEKEIKQLEEEKAALNVK----------- 489
+KL E +++++++R++ +EK+IK LE EK A + K
Sbjct: 758 TEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGR 817
Query: 490 ------LQNSLLEVLRLEEFIQQNKT--RPTGAEESPQELGRQHCSILETQDPCLKLDET 541
LQ +L EV +++E +++ + AE S + + Q S+ ET + + +E
Sbjct: 818 ELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQR-SMQETVNKLHQKEEQ 876
Query: 542 ----SPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLGSLLK---EKTSKIQRL 594
S E+ ++ LA E +++ER + L+K + + ++K + +S++ ++
Sbjct: 877 FNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKM 936
Query: 595 E----------EDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQR- 643
E+ Q + K S +Q+++E T + Q + + E+++L+R
Sbjct: 937 NDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERK 996
Query: 644 --ELQETTQQNHAMKAQLEASHQRALRMLEKARHQELKATEERLKKESSHSLQIQHQTHR 701
+L++ + +H +L+A ++RA K +H+E+ ++ ++ L+ + +
Sbjct: 997 LSDLEKKMETSHNQCQELKARYERATSET-KTKHEEILQNLQKTLLDTEDKLKGAREENS 1055
Query: 702 LELQALEEKARQELQEERERMQAQQAL-LLESLRQELSEQQAACSGHQKDLEALQAELRA 760
LQ LEE R++ + + A+ A+ ++E + +E +E A+ ++ LQ EL
Sbjct: 1056 GLLQELEE-LRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDT 1114
Query: 761 LGRQQASSQCPGDSKDHIIATEERGGPG---QAGSPPGAAGQGSGEGCGLWEENAQLQDA 817
L + + ++ E + + + AA Q S + L EEN +L +
Sbjct: 1115 LKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEE 1174
Query: 818 VRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRAREVETLR--QEHRKEMQAMVADFSSA 875
+ R R EV H QKL ++R L + RE + ++ E + +Q ++ S+
Sbjct: 1175 LGRSRDEVTSH----QKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSAL 1230
Query: 876 QAQLQARLAALEAEL 890
+ A L L E+
Sbjct: 1231 LTEKDAELEKLRNEV 1245
Score = 88.2 bits (217), Expect = 4e-17
Identities = 137/682 (20%), Positives = 295/682 (43%), Gaps = 67/682 (9%)
Query: 57 DEAEASMEALREAHQEELQNAVAETKARLLQEQGCAEEEALLQRIQA-LESALELQKRLT 115
+ + ++ R AH +E++ +A+L++ E+E L+ I++ L+ A +
Sbjct: 664 ENLQNQQDSERAAHAKEME----ALRAKLMKV--IKEKENSLEAIRSKLDKAEDQHLVEM 717
Query: 116 EEALAESASCRLETKERELRVEAEHAERVLTLSREMLELKADYERRLQHLTSHEATPQGR 175
E+ L + ++ KE E+ ++A+ E+ + +LKA E+ L +A+ +G+
Sbjct: 718 EDTLNKLQEAEIKVKELEV-LQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGK 776
Query: 176 LPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYARKAEELQATYERENEAIRQA 235
+ + E E Q LE+++ ++ S + EL+ T +EN +
Sbjct: 777 SEMKKLRQQLEAA---EKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQ 833
Query: 236 MQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEHRGRKISDLKKYAQKLKE 295
+++++ + L +EK ++ + + ++Q V KL E SDL +KL+E
Sbjct: 834 VKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDL----EKLRE 889
Query: 296 RIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECRGTQQTDAMKTELVSENK 355
+ D++ + +E + +L +KL +A +M + Q M EL +
Sbjct: 890 NLADMEAKFREKDEREEQLIKAKEKLENDIA----EIMKMSGDNSSQLTKMNDELRLKE- 944
Query: 356 VLREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEASAETEYMKQQYEEDLRKIKH 415
R+ +L+ ++ S L+ K DM K E S + K + E+ + K
Sbjct: 945 --RDVEELQLKLTKANENASFLQ-----KSIEDMTVKAEQSQQEAAKKHEEEKKELERKL 997
Query: 416 QTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERKKLQREVEAQLEEVRKKSEKE 475
E+K + L+ ++ T E K+ + +K + E +L+ R+++
Sbjct: 998 SDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGL 1057
Query: 476 IKQLEE-EKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEESPQELGRQHCSILET-QD 533
+++LEE K A K + + +++ E + + KT + E ++ + + L+T ++
Sbjct: 1058 LQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKE 1117
Query: 534 PCLK-----------LDETSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLGS 582
LK L + + EE++ ++ + ++ + ++ L +E LG
Sbjct: 1118 NNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGR 1177
Query: 583 LLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQ 642
E TS Q+LEE+ ++ L Q+ +M++ RE K + D + EK
Sbjct: 1178 SRDEVTSH-QKLEEE----RSVLNNQLLEMKK---------RES----KFIKDADEEKAS 1219
Query: 643 RELQETTQQNHAMKAQLEASHQRALRMLEKARHQELKATEERLKKESSHSLQIQHQTHRL 702
LQ++ A+ + +A LEK R++ E +S HS+ ++ ++
Sbjct: 1220 --LQKSISITSALLTEKDAE-------LEKLRNEVTVLRGENASAKSLHSVVQTLESDKV 1270
Query: 703 ELQALEEKARQELQEERERMQA 724
+L+ + +L+E + ++ +
Sbjct: 1271 KLELKVKNLELQLKENKRQLSS 1292
Score = 84.3 bits (207), Expect = 5e-16
Identities = 155/721 (21%), Positives = 296/721 (41%), Gaps = 131/721 (18%)
Query: 34 MHVKMCKKIAQLTKVIYALNTRQDEAEASMEALREAHQEELQNAVAETKARLLQEQGCAE 93
+ K+ K I + + A+ ++ D+AE E +LQ A + K + + C E
Sbjct: 684 LRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNE 743
Query: 94 EEALLQRIQALESALELQKRLTEEALAESASCRLETKERELRVEAEHAERVL-------- 145
+ ++ + A E +K L +AL + AS +++ ++LR + E AE+ +
Sbjct: 744 QTKVIDNFTSQLKATE-EKLLDLDALRK-ASSEGKSEMKKLRQQLEAAEKQIKHLEIEKN 801
Query: 146 -------TLSREML--ELKADYERRLQHLTSHEATPQGRLPQESPETKSEPGQGPE---- 192
+++RE+ ELK LQ S + + L +E K + + E
Sbjct: 802 AESSKASSITRELQGRELKLT---NLQENLSEVSQVKETLEKELQILKEKFAEASEEAVS 858
Query: 193 ----MQEVLLEVQRLRVENQQLSKDYARKAEEL---QATY----ERENEAIR--QAMQQS 239
MQE + ++ + + LS D + E L +A + ERE + I+ + ++
Sbjct: 859 VQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLEND 918
Query: 240 VSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEHRGRKISDLKKYAQKLKERIQD 299
+++ + + S L K + ++R E D+E K++ + A L++ I+D
Sbjct: 919 IAEIMKMSGDNSSQLTK--------MNDELRLKERDVEELQLKLTKANENASFLQKSIED 970
Query: 300 LDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECRGTQQTDAMKTELVSENKVLRE 359
+ V+ ++++QE ++ KK E+ ++ M Q+ A SE K E
Sbjct: 971 MTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHE 1030
Query: 360 ENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEE 419
E NL K D + K + + E Q E+LRK Q ++
Sbjct: 1031 E---ILQNL--------------QKTLLDTEDKLKGAREENSGLLQELEELRK---QADK 1070
Query: 420 EK-KHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERKKLQREVEAQLEEVRKKSEKEIKQ 478
K + ++ +E + K+ T + S+ + K+ +++ +L+ +++ + K +++
Sbjct: 1071 AKAAQTAEDAMQIMEQMTKEKTETLASLE-----DTKQTNAKLQNELDTLKENNLKNVEE 1125
Query: 479 LEEEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEESPQELGRQHCSILETQDPCLKL 538
L + K L V+ Q ++EEF ++ +T A + Q+L
Sbjct: 1126 LNKSKELLTVENQ-------KMEEFRKEIETLKQAAAQKSQQLSAL-------------- 1164
Query: 539 DETSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLGSLLKEKTSKIQRLEEDW 598
+E KLA E G S DE + L +E S L + L E + + +D
Sbjct: 1165 -------QEENVKLAEELGRSRDEVTSHQKLEEERS----VLNNQLLEMKKRESKFIKDA 1213
Query: 599 QSQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMK-- 656
+KA LQ +S TS AL D E EKL+ E+ +N + K
Sbjct: 1214 DEEKASLQKSIS--------ITS-------ALLTEKDAELEKLRNEVTVLRGENASAKSL 1258
Query: 657 -AQLEASHQRALRMLEKARHQELKATEERLKKESSHSLQIQHQTHRLELQALEEKARQEL 715
+ ++ +++ K ++ EL+ E + + SS + + QA E++ QE
Sbjct: 1259 HSVVQTLESDKVKLELKVKNLELQLKENKRQLSSS--------SGNTDTQADEDERAQES 1310
Query: 716 Q 716
Q
Sbjct: 1311 Q 1311
Score = 80.9 bits (198), Expect = 6e-15
Identities = 158/735 (21%), Positives = 305/735 (41%), Gaps = 111/735 (15%)
Query: 281 RKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGE---KLAVAKDRMMLQEC 337
RKIS + LKE+ Q ++ L E E +E+ +GE +LA+A+D
Sbjct: 345 RKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVL 404
Query: 338 RGTQQTDAMKTEL-VSENKVLREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEAS 396
+ D ++T + ++ + + N LE + Q ++E KG + QTK E +
Sbjct: 405 ELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHA 464
Query: 397 AETEYMK---------QQYEEDLRKIKHQTEEEKKHLKD-------------QLVKRLE- 433
E + + + +L + T EK + + +L +RLE
Sbjct: 465 RIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLES 524
Query: 434 -------DLVKKHTVEIKSVRSSVEAERKKLQREVEAQLEEVRKKSE---KEIK------ 477
D+ EI S++ +E R QRE+ + E + E KEIK
Sbjct: 525 NKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTAT 584
Query: 478 -QLEEEKAALNVKLQNS--------LLEVLRLEEFIQQNKTRPTGAEES-PQELGRQHCS 527
+L +E +L KL+++ L +LE I ++ + S + LG +
Sbjct: 585 EKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAE 644
Query: 528 I--LETQDPCLKLDETSPRGEEYQDKLAAEEGTSSDEEE--RTKVL--LKEGSDPQPPLG 581
L+TQ ++LD E Q++ +E + E E R K++ +KE + +
Sbjct: 645 FAELKTQIEKMRLD-YQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIR 703
Query: 582 SLL-----------KEKTSKIQRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYRE----- 625
S L ++ +K+Q E + + LQA+ ++ + ++ TS +
Sbjct: 704 SKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEV-LQAKCNEQTKVIDNFTSQLKATEEKL 762
Query: 626 -DLQALKQLSD---LEREKLQRELQETTQQNHAMKAQLEASHQRALRMLEKARHQELKAT 681
DL AL++ S E +KL+++L+ +Q ++ + A +A + + + +ELK T
Sbjct: 763 LDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLT 822
Query: 682 EERLKKESSHSLQIQHQTHRLELQALEEKARQELQEERERMQAQQALLLESLRQELSEQQ 741
L++ S Q++ +T ELQ L+EK E EE +Q + L Q+ +
Sbjct: 823 --NLQENLSEVSQVK-ETLEKELQILKEKF-AEASEEAVSVQRSMQETVNKLHQKEEQFN 878
Query: 742 AACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGAAGQGS 801
S DLE L+ L + +A + + ++ +I +E+ + + S
Sbjct: 879 MLSS----DLEKLRENLADM---EAKFREKDEREEQLIKAKEK-----LENDIAEIMKMS 926
Query: 802 GEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLEET------QQAQRAREVE 855
G+ + ++ D +R +VE+ Q + K + FL+++ + Q +E
Sbjct: 927 GDNS---SQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAA 983
Query: 856 TLRQEHRKEMQAMVADFSSAQAQLQARLAALEAELKDSGEKPGKGASRPEDLQLIGRLQT 915
+E +KE++ ++D + L+A + + + ++ + +++ LQ
Sbjct: 984 KKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSE-----TKTKHEEILQNLQK 1038
Query: 916 RLKEREDIIKQLTEE 930
L + ED +K EE
Sbjct: 1039 TLLDTEDKLKGAREE 1053
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 129 bits (324), Expect = 1e-29
Identities = 229/1037 (22%), Positives = 429/1037 (41%), Gaps = 159/1037 (15%)
Query: 40 KKIAQLTKVIYALNTRQDEAEASMEALREAHQE--ELQNAVA---ETKARLLQE-----Q 89
K + Q+T+ L R E + E +++ +E ELQ VA E +ARL ++ +
Sbjct: 867 KPLLQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAE 926
Query: 90 GCAEEEALLQRIQALESALELQKRLTEEALAESASC--RLETKERELR---------VEA 138
CAE E R+ A + LEL E + E C +++T+++ L+ +EA
Sbjct: 927 LCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEA 986
Query: 139 EHAERV------LTLSREMLELKADY---ERRLQHLTSHEATPQGRLPQESPETKSEPGQ 189
E R +T +M + + D E + L+ + RL + S + E +
Sbjct: 987 EEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEK 1046
Query: 190 GPEMQEVLLEVQRLRVENQQLSKDYARKAEELQATYERENEAIRQAMQQSVSQALWQWQE 249
+ ++ L+ + + + + + +EL+ R + + +Q V Q Q+
Sbjct: 1047 VKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQ-----QQ 1101
Query: 250 KESDLRKNFQVQESALQAQVRKLEGDLEHRGRKISDLKKYAQKLKERIQDLDVQL----- 304
+ +LR +E LQA + + E + R + + L++ L E +DL+ +
Sbjct: 1102 RAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTK 1161
Query: 305 --KEARQENSELKGTAKKLGEKLAVAKDRMMLQECRGTQQTDAMKTELVSENKV------ 356
K+ R EL+ +L + L + L+ R + T+ KT L E ++
Sbjct: 1162 AEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKT-LEEETRIHEAAVQ 1220
Query: 357 -LREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTK-KEASAETEYM---KQQYEEDLR 411
LR+ + G L Q +Q+ + K ++ + E AE + +Q+ E+ R
Sbjct: 1221 ELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRR 1280
Query: 412 KIKHQTEEEKKHLKDQLVKRLE--DLVKKHTVEIKSVRSSV-EAERKKLQREVEAQLEEV 468
+++ Q +E + D R E + +++ E+++V ++ EAE K ++ E E
Sbjct: 1281 RLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEA 1340
Query: 469 RKKSEKEIKQLE-EEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEESPQELGRQHCS 527
+ +E+ Q E K AL +++ E L E +++ E + +EL
Sbjct: 1341 QLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEE---EAAARERAGRELQTAQAQ 1397
Query: 528 ILETQDPCLKLDETSPRGEEYQDKLA----------AEEGTSSDEEERTKVLLKEGSDPQ 577
+ E + + GEE + + A AE+ + D ER + L++ D
Sbjct: 1398 LSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDA 1457
Query: 578 PPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYRE-DLQALKQLSDL 636
++ S +++ + + A+ +A V + + E+ + RE + +AL L
Sbjct: 1458 TMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRAL 1517
Query: 637 EREKLQRELQETTQQNHAMKAQLEA-------------SHQRALRMLEKARH-------- 675
E E+ RE E +QN A++A+LEA +RA R+ E+A +
Sbjct: 1518 EEEQEARE--ELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTE 1575
Query: 676 --QELKATEERLKKESSHSLQIQHQTHRLELQ----ALEEKARQ--------ELQEERER 721
EL A E+ K ++Q H +LQ A EE+ RQ E++ + ER
Sbjct: 1576 LEDELTAAED-AKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEER 1634
Query: 722 MQAQQALL----LESLRQELSEQQAACSGHQ----KDLEALQAELRALGRQ--------- 764
Q A+ LE +EL Q A+ + K L +QA+++ L R+
Sbjct: 1635 KQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSRE 1694
Query: 765 -------QASSQCPGDSKDHIIATEERGGPGQA--------GSPPGAAGQGSGEGCGLWE 809
++ + G + + EE +A G+ + E
Sbjct: 1695 EIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILE 1754
Query: 810 ENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFL---------EETQQAQRAREVETLRQE 860
E QL+ + +L E+E+ Q ++ L D+ R L E + + + + E+ RQ+
Sbjct: 1755 EKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQ 1814
Query: 861 HRKEMQAMVADFSSAQAQLQAR----LAALEAELKDSGEK-PGKGASRPEDLQLIGRLQT 915
+++Q + A +AR +AALE++L + E+ + R +L+ R +
Sbjct: 1815 LERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEK 1874
Query: 916 RLKEREDIIKQLTEERR 932
RLKE ++ Q+ EERR
Sbjct: 1875 RLKE---VVLQVEEERR 1888
Score = 114 bits (286), Expect = 4e-25
Identities = 169/775 (21%), Positives = 315/775 (40%), Gaps = 94/775 (12%)
Query: 40 KKIAQLTKVIYALNTRQDEAEASMEALREAHQEELQNAVAETKARLLQEQGCAEEEALLQ 99
K+ ++T++ L EA+++ LR+ H + L +AE + + +G E+ L
Sbjct: 1196 KREQEVTELKKTLEEETRIHEAAVQELRQRHGQAL-GELAEQLEQARRGKGAWEKTRLAL 1254
Query: 100 RIQALESALELQKRLTEEALAESASCRLETKERELRVEAEHAERVLTLSREMLELKADYE 159
+ E EL T E RLE + +E++ A ER + E L+ +
Sbjct: 1255 EAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRA---Q 1311
Query: 160 RRLQHLTSHEATPQGRLPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYARKAE 219
L++++ + + + S E S Q + QE+L E R ++ + +A
Sbjct: 1312 AELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAA 1371
Query: 220 ELQATYERENEAIRQAMQ--QSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLE 277
L+ E E A +A + Q+ L +W+ ++ + + E A + R+ E +
Sbjct: 1372 GLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQ 1431
Query: 278 HRGRK---ISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMM- 333
K + L++ ++L++ + D + L++ RQ S L+ +K + LA K ++
Sbjct: 1432 RLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLR 1491
Query: 334 -------------------LQECRGTQQTDAMKTELVSENKVLREE-------------- 360
L R ++ + EL +N+ LR E
Sbjct: 1492 AVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKS 1551
Query: 361 -NDLEAGNLHPQQDQSCLKECPC-----MKGGTDMQTKKEASAETEYMKQQYEEDLRKIK 414
++LE +Q + L+ + D + + E + + +K Q+E DL+
Sbjct: 1552 VHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQA--LKTQHERDLQGRD 1609
Query: 415 HQTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERKKLQREVE---AQLEEVRKK 471
EE ++ QL K+L D + E K R+ A RKKL+ E+E AQ+ +
Sbjct: 1610 EAGEERRR----QLAKQLRDAEVERDEERKQ-RTLAVAARKKLEGELEELKAQMASAGQG 1664
Query: 472 SEKEIKQLEEEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEESPQELGRQHCSILET 531
E+ +KQL + +A + + EE QN+ ES + L +L
Sbjct: 1665 KEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNR-------ESEKRLKGLEAEVLRL 1717
Query: 532 QDPCLKLDETSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLGSLLKEKTSKI 591
Q+ D + ++ +D++A E + + +L+E + LG L +E
Sbjct: 1718 QEELAASDRARRQAQQDRDEMADEVANGNLSKA---AILEEKRQLEGRLGQLEEE----- 1769
Query: 592 QRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQRELQETTQQ 651
LEE+ QS L + ++ +E T+ + ++ ++ R++L+R++QE +
Sbjct: 1770 --LEEE-QSNSELLNDRYRKLLLQVESLTTELSAE-RSFSAKAESGRQQLERQIQELRGR 1825
Query: 652 NHAMKAQLEASHQRALRMLEKARHQELKATEERLKKESSHSLQIQHQTHRLELQALEEKA 711
A A H+ + LE +L EE+L++E+ + R E + E
Sbjct: 1826 LGEEDAGARARHKMTIAALE----SKLAQAEEQLEQETRERILSGKLVRRAEKRLKE--- 1878
Query: 712 RQELQEERERMQAQQA--------LLLESLRQELSEQQAACSGHQKDLEALQAEL 758
LQ E ER A Q L ++ L+++L E + S Q LQ EL
Sbjct: 1879 -VVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQREL 1932
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 129 bits (324), Expect = 1e-29
Identities = 229/1037 (22%), Positives = 429/1037 (41%), Gaps = 159/1037 (15%)
Query: 40 KKIAQLTKVIYALNTRQDEAEASMEALREAHQE--ELQNAVA---ETKARLLQE-----Q 89
K + Q+T+ L R E + E +++ +E ELQ VA E +ARL ++ +
Sbjct: 859 KPLLQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAE 918
Query: 90 GCAEEEALLQRIQALESALELQKRLTEEALAESASC--RLETKERELR---------VEA 138
CAE E R+ A + LEL E + E C +++T+++ L+ +EA
Sbjct: 919 LCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEA 978
Query: 139 EHAERV------LTLSREMLELKADY---ERRLQHLTSHEATPQGRLPQESPETKSEPGQ 189
E R +T +M + + D E + L+ + RL + S + E +
Sbjct: 979 EEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEK 1038
Query: 190 GPEMQEVLLEVQRLRVENQQLSKDYARKAEELQATYERENEAIRQAMQQSVSQALWQWQE 249
+ ++ L+ + + + + + +EL+ R + + +Q V Q Q+
Sbjct: 1039 VKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQ-----QQ 1093
Query: 250 KESDLRKNFQVQESALQAQVRKLEGDLEHRGRKISDLKKYAQKLKERIQDLDVQL----- 304
+ +LR +E LQA + + E + R + + L++ L E +DL+ +
Sbjct: 1094 RAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTK 1153
Query: 305 --KEARQENSELKGTAKKLGEKLAVAKDRMMLQECRGTQQTDAMKTELVSENKV------ 356
K+ R EL+ +L + L + L+ R + T+ KT L E ++
Sbjct: 1154 AEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKT-LEEETRIHEAAVQ 1212
Query: 357 -LREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTK-KEASAETEYM---KQQYEEDLR 411
LR+ + G L Q +Q+ + K ++ + E AE + +Q+ E+ R
Sbjct: 1213 ELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRR 1272
Query: 412 KIKHQTEEEKKHLKDQLVKRLE--DLVKKHTVEIKSVRSSV-EAERKKLQREVEAQLEEV 468
+++ Q +E + D R E + +++ E+++V ++ EAE K ++ E E
Sbjct: 1273 RLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEA 1332
Query: 469 RKKSEKEIKQLE-EEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEESPQELGRQHCS 527
+ +E+ Q E K AL +++ E L E +++ E + +EL
Sbjct: 1333 QLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEE---EAAARERAGRELQTAQAQ 1389
Query: 528 ILETQDPCLKLDETSPRGEEYQDKLA----------AEEGTSSDEEERTKVLLKEGSDPQ 577
+ E + + GEE + + A AE+ + D ER + L++ D
Sbjct: 1390 LSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDA 1449
Query: 578 PPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYRE-DLQALKQLSDL 636
++ S +++ + + A+ +A V + + E+ + RE + +AL L
Sbjct: 1450 TMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRAL 1509
Query: 637 EREKLQRELQETTQQNHAMKAQLEA-------------SHQRALRMLEKARH-------- 675
E E+ RE E +QN A++A+LEA +RA R+ E+A +
Sbjct: 1510 EEEQEARE--ELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTE 1567
Query: 676 --QELKATEERLKKESSHSLQIQHQTHRLELQ----ALEEKARQ--------ELQEERER 721
EL A E+ K ++Q H +LQ A EE+ RQ E++ + ER
Sbjct: 1568 LEDELTAAED-AKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEER 1626
Query: 722 MQAQQALL----LESLRQELSEQQAACSGHQ----KDLEALQAELRALGRQ--------- 764
Q A+ LE +EL Q A+ + K L +QA+++ L R+
Sbjct: 1627 KQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSRE 1686
Query: 765 -------QASSQCPGDSKDHIIATEERGGPGQA--------GSPPGAAGQGSGEGCGLWE 809
++ + G + + EE +A G+ + E
Sbjct: 1687 EIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILE 1746
Query: 810 ENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFL---------EETQQAQRAREVETLRQE 860
E QL+ + +L E+E+ Q ++ L D+ R L E + + + + E+ RQ+
Sbjct: 1747 EKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQ 1806
Query: 861 HRKEMQAMVADFSSAQAQLQAR----LAALEAELKDSGEK-PGKGASRPEDLQLIGRLQT 915
+++Q + A +AR +AALE++L + E+ + R +L+ R +
Sbjct: 1807 LERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEK 1866
Query: 916 RLKEREDIIKQLTEERR 932
RLKE ++ Q+ EERR
Sbjct: 1867 RLKE---VVLQVEEERR 1880
Score = 114 bits (286), Expect = 4e-25
Identities = 169/775 (21%), Positives = 315/775 (40%), Gaps = 94/775 (12%)
Query: 40 KKIAQLTKVIYALNTRQDEAEASMEALREAHQEELQNAVAETKARLLQEQGCAEEEALLQ 99
K+ ++T++ L EA+++ LR+ H + L +AE + + +G E+ L
Sbjct: 1188 KREQEVTELKKTLEEETRIHEAAVQELRQRHGQAL-GELAEQLEQARRGKGAWEKTRLAL 1246
Query: 100 RIQALESALELQKRLTEEALAESASCRLETKERELRVEAEHAERVLTLSREMLELKADYE 159
+ E EL T E RLE + +E++ A ER + E L+ +
Sbjct: 1247 EAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRA---Q 1303
Query: 160 RRLQHLTSHEATPQGRLPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYARKAE 219
L++++ + + + S E S Q + QE+L E R ++ + +A
Sbjct: 1304 AELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAA 1363
Query: 220 ELQATYERENEAIRQAMQ--QSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLE 277
L+ E E A +A + Q+ L +W+ ++ + + E A + R+ E +
Sbjct: 1364 GLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQ 1423
Query: 278 HRGRK---ISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMM- 333
K + L++ ++L++ + D + L++ RQ S L+ +K + LA K ++
Sbjct: 1424 RLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLR 1483
Query: 334 -------------------LQECRGTQQTDAMKTELVSENKVLREE-------------- 360
L R ++ + EL +N+ LR E
Sbjct: 1484 AVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKS 1543
Query: 361 -NDLEAGNLHPQQDQSCLKECPC-----MKGGTDMQTKKEASAETEYMKQQYEEDLRKIK 414
++LE +Q + L+ + D + + E + + +K Q+E DL+
Sbjct: 1544 VHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQA--LKTQHERDLQGRD 1601
Query: 415 HQTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERKKLQREVE---AQLEEVRKK 471
EE ++ QL K+L D + E K R+ A RKKL+ E+E AQ+ +
Sbjct: 1602 EAGEERRR----QLAKQLRDAEVERDEERKQ-RTLAVAARKKLEGELEELKAQMASAGQG 1656
Query: 472 SEKEIKQLEEEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEESPQELGRQHCSILET 531
E+ +KQL + +A + + EE QN+ ES + L +L
Sbjct: 1657 KEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNR-------ESEKRLKGLEAEVLRL 1709
Query: 532 QDPCLKLDETSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLGSLLKEKTSKI 591
Q+ D + ++ +D++A E + + +L+E + LG L +E
Sbjct: 1710 QEELAASDRARRQAQQDRDEMADEVANGNLSKA---AILEEKRQLEGRLGQLEEE----- 1761
Query: 592 QRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQRELQETTQQ 651
LEE+ QS L + ++ +E T+ + ++ ++ R++L+R++QE +
Sbjct: 1762 --LEEE-QSNSELLNDRYRKLLLQVESLTTELSAE-RSFSAKAESGRQQLERQIQELRGR 1817
Query: 652 NHAMKAQLEASHQRALRMLEKARHQELKATEERLKKESSHSLQIQHQTHRLELQALEEKA 711
A A H+ + LE +L EE+L++E+ + R E + E
Sbjct: 1818 LGEEDAGARARHKMTIAALE----SKLAQAEEQLEQETRERILSGKLVRRAEKRLKE--- 1870
Query: 712 RQELQEERERMQAQQA--------LLLESLRQELSEQQAACSGHQKDLEALQAEL 758
LQ E ER A Q L ++ L+++L E + S Q LQ EL
Sbjct: 1871 -VVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQREL 1924
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 129 bits (324), Expect = 1e-29
Identities = 229/1037 (22%), Positives = 429/1037 (41%), Gaps = 159/1037 (15%)
Query: 40 KKIAQLTKVIYALNTRQDEAEASMEALREAHQE--ELQNAVA---ETKARLLQE-----Q 89
K + Q+T+ L R E + E +++ +E ELQ VA E +ARL ++ +
Sbjct: 900 KPLLQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAE 959
Query: 90 GCAEEEALLQRIQALESALELQKRLTEEALAESASC--RLETKERELR---------VEA 138
CAE E R+ A + LEL E + E C +++T+++ L+ +EA
Sbjct: 960 LCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEA 1019
Query: 139 EHAERV------LTLSREMLELKADY---ERRLQHLTSHEATPQGRLPQESPETKSEPGQ 189
E R +T +M + + D E + L+ + RL + S + E +
Sbjct: 1020 EEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEK 1079
Query: 190 GPEMQEVLLEVQRLRVENQQLSKDYARKAEELQATYERENEAIRQAMQQSVSQALWQWQE 249
+ ++ L+ + + + + + +EL+ R + + +Q V Q Q+
Sbjct: 1080 VKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQ-----QQ 1134
Query: 250 KESDLRKNFQVQESALQAQVRKLEGDLEHRGRKISDLKKYAQKLKERIQDLDVQL----- 304
+ +LR +E LQA + + E + R + + L++ L E +DL+ +
Sbjct: 1135 RAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTK 1194
Query: 305 --KEARQENSELKGTAKKLGEKLAVAKDRMMLQECRGTQQTDAMKTELVSENKV------ 356
K+ R EL+ +L + L + L+ R + T+ KT L E ++
Sbjct: 1195 AEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKT-LEEETRIHEAAVQ 1253
Query: 357 -LREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTK-KEASAETEYM---KQQYEEDLR 411
LR+ + G L Q +Q+ + K ++ + E AE + +Q+ E+ R
Sbjct: 1254 ELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRR 1313
Query: 412 KIKHQTEEEKKHLKDQLVKRLE--DLVKKHTVEIKSVRSSV-EAERKKLQREVEAQLEEV 468
+++ Q +E + D R E + +++ E+++V ++ EAE K ++ E E
Sbjct: 1314 RLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEA 1373
Query: 469 RKKSEKEIKQLE-EEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEESPQELGRQHCS 527
+ +E+ Q E K AL +++ E L E +++ E + +EL
Sbjct: 1374 QLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEE---EAAARERAGRELQTAQAQ 1430
Query: 528 ILETQDPCLKLDETSPRGEEYQDKLA----------AEEGTSSDEEERTKVLLKEGSDPQ 577
+ E + + GEE + + A AE+ + D ER + L++ D
Sbjct: 1431 LSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDA 1490
Query: 578 PPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYRE-DLQALKQLSDL 636
++ S +++ + + A+ +A V + + E+ + RE + +AL L
Sbjct: 1491 TMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRAL 1550
Query: 637 EREKLQRELQETTQQNHAMKAQLEA-------------SHQRALRMLEKARH-------- 675
E E+ RE E +QN A++A+LEA +RA R+ E+A +
Sbjct: 1551 EEEQEARE--ELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTE 1608
Query: 676 --QELKATEERLKKESSHSLQIQHQTHRLELQ----ALEEKARQ--------ELQEERER 721
EL A E+ K ++Q H +LQ A EE+ RQ E++ + ER
Sbjct: 1609 LEDELTAAED-AKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEER 1667
Query: 722 MQAQQALL----LESLRQELSEQQAACSGHQ----KDLEALQAELRALGRQ--------- 764
Q A+ LE +EL Q A+ + K L +QA+++ L R+
Sbjct: 1668 KQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSRE 1727
Query: 765 -------QASSQCPGDSKDHIIATEERGGPGQA--------GSPPGAAGQGSGEGCGLWE 809
++ + G + + EE +A G+ + E
Sbjct: 1728 EIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILE 1787
Query: 810 ENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFL---------EETQQAQRAREVETLRQE 860
E QL+ + +L E+E+ Q ++ L D+ R L E + + + + E+ RQ+
Sbjct: 1788 EKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQ 1847
Query: 861 HRKEMQAMVADFSSAQAQLQAR----LAALEAELKDSGEK-PGKGASRPEDLQLIGRLQT 915
+++Q + A +AR +AALE++L + E+ + R +L+ R +
Sbjct: 1848 LERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEK 1907
Query: 916 RLKEREDIIKQLTEERR 932
RLKE ++ Q+ EERR
Sbjct: 1908 RLKE---VVLQVEEERR 1921
Score = 114 bits (286), Expect = 4e-25
Identities = 169/775 (21%), Positives = 315/775 (40%), Gaps = 94/775 (12%)
Query: 40 KKIAQLTKVIYALNTRQDEAEASMEALREAHQEELQNAVAETKARLLQEQGCAEEEALLQ 99
K+ ++T++ L EA+++ LR+ H + L +AE + + +G E+ L
Sbjct: 1229 KREQEVTELKKTLEEETRIHEAAVQELRQRHGQAL-GELAEQLEQARRGKGAWEKTRLAL 1287
Query: 100 RIQALESALELQKRLTEEALAESASCRLETKERELRVEAEHAERVLTLSREMLELKADYE 159
+ E EL T E RLE + +E++ A ER + E L+ +
Sbjct: 1288 EAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRA---Q 1344
Query: 160 RRLQHLTSHEATPQGRLPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYARKAE 219
L++++ + + + S E S Q + QE+L E R ++ + +A
Sbjct: 1345 AELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAA 1404
Query: 220 ELQATYERENEAIRQAMQ--QSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLE 277
L+ E E A +A + Q+ L +W+ ++ + + E A + R+ E +
Sbjct: 1405 GLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQ 1464
Query: 278 HRGRK---ISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMM- 333
K + L++ ++L++ + D + L++ RQ S L+ +K + LA K ++
Sbjct: 1465 RLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLR 1524
Query: 334 -------------------LQECRGTQQTDAMKTELVSENKVLREE-------------- 360
L R ++ + EL +N+ LR E
Sbjct: 1525 AVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKS 1584
Query: 361 -NDLEAGNLHPQQDQSCLKECPC-----MKGGTDMQTKKEASAETEYMKQQYEEDLRKIK 414
++LE +Q + L+ + D + + E + + +K Q+E DL+
Sbjct: 1585 VHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQA--LKTQHERDLQGRD 1642
Query: 415 HQTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERKKLQREVE---AQLEEVRKK 471
EE ++ QL K+L D + E K R+ A RKKL+ E+E AQ+ +
Sbjct: 1643 EAGEERRR----QLAKQLRDAEVERDEERKQ-RTLAVAARKKLEGELEELKAQMASAGQG 1697
Query: 472 SEKEIKQLEEEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEESPQELGRQHCSILET 531
E+ +KQL + +A + + EE QN+ ES + L +L
Sbjct: 1698 KEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNR-------ESEKRLKGLEAEVLRL 1750
Query: 532 QDPCLKLDETSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLGSLLKEKTSKI 591
Q+ D + ++ +D++A E + + +L+E + LG L +E
Sbjct: 1751 QEELAASDRARRQAQQDRDEMADEVANGNLSKA---AILEEKRQLEGRLGQLEEE----- 1802
Query: 592 QRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQRELQETTQQ 651
LEE+ QS L + ++ +E T+ + ++ ++ R++L+R++QE +
Sbjct: 1803 --LEEE-QSNSELLNDRYRKLLLQVESLTTELSAE-RSFSAKAESGRQQLERQIQELRGR 1858
Query: 652 NHAMKAQLEASHQRALRMLEKARHQELKATEERLKKESSHSLQIQHQTHRLELQALEEKA 711
A A H+ + LE +L EE+L++E+ + R E + E
Sbjct: 1859 LGEEDAGARARHKMTIAALE----SKLAQAEEQLEQETRERILSGKLVRRAEKRLKE--- 1911
Query: 712 RQELQEERERMQAQQA--------LLLESLRQELSEQQAACSGHQKDLEALQAEL 758
LQ E ER A Q L ++ L+++L E + S Q LQ EL
Sbjct: 1912 -VVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQREL 1965
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 129 bits (323), Expect = 2e-29
Identities = 138/698 (19%), Positives = 313/698 (44%), Gaps = 50/698 (7%)
Query: 192 EMQEVLLEVQRLRVENQQLSKDYARKAEELQATYERENEA---IRQAMQQSVSQALWQWQ 248
E + LE+ R + N++L K A E+L ++E +++ ++ Q
Sbjct: 205 ERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQ 264
Query: 249 EKESDLRKNFQVQESALQAQVRKLEGDLEHRGRKISDLKKYAQKLKERIQDLDVQLKEAR 308
+ + L++ QE L+ Q +K+ E R+ L++ K++E+ + + Q K R
Sbjct: 265 VQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLR 324
Query: 309 QENSELKGTAKKLGE--KLAVAKDRMMLQECRGTQQTDAMKTELVSENKVLREENDL--E 364
++ EL+ K+L E +L +++M QE + +Q + M+ + E K+ R+E L +
Sbjct: 325 EQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQ---EEKMWRQEERLWEQ 381
Query: 365 AGNLHPQQDQSCLKECPCMKGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEEKKHL 424
+ Q+ + +E + ++ K+E E E M +Q E+ +R+ K E+EKK
Sbjct: 382 EKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEK-MREEKKMQEQEKKTR 440
Query: 425 KDQLVKRLEDLVKKHTVEIKSVRSSVEAERKKLQREVEAQLEEVRKKSEKEIKQLEEEKA 484
+ + E+ +++ +++ ++ + +K+Q++ E E+ K+ +++ ++EK
Sbjct: 441 DQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKL 500
Query: 485 ALNVKLQNSLLEVLRLEEFIQQNKT---------RPTGAEESPQELGRQHCSILETQDPC 535
K+Q ++ EE I+ + R E ++ Q + + +
Sbjct: 501 WEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKM 560
Query: 536 LKLDETSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLGSLLKEKTSKIQRLE 595
+E + + Q+K ++ EEER + K+ + + +++E+ K+Q E
Sbjct: 561 WDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEE----EMMREQEEKMQEQE 616
Query: 596 EDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQREL---QETTQQN 652
E Q Q+ K+ Q +MQ+ E+ + + +++ + +R Q+E E Q+
Sbjct: 617 EKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQ 676
Query: 653 HAMKAQLEASHQRALRMLEKARHQELKATEERLKKESSHSLQIQHQTHRLELQALEEKAR 712
M+ Q E ++ +EK ++ K T ++ K S++ + + R E + + E+
Sbjct: 677 EKMQEQEEKIWEQ--EKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQ-E 733
Query: 713 QELQEERERMQAQQALLLES------------LRQELSEQQAACSGHQKDLE-----ALQ 755
+++QE+ E+MQ Q+ + E +Q L EQ+ H+K E +
Sbjct: 734 EKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQE 793
Query: 756 AELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGAAGQGSGEGCGLWEENAQLQ 815
++R + + ++ + +E GQ G + G+ +W + +++
Sbjct: 794 EKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKME 853
Query: 816 DAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRARE 853
+ +++ + E+ +++ +K+R Q + E ++ R +E
Sbjct: 854 E---KMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQE 888
Score = 85.5 bits (210), Expect = 2e-16
Identities = 151/803 (18%), Positives = 332/803 (41%), Gaps = 133/803 (16%)
Query: 159 ERRLQHLTSHEATPQG--RLPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQ------- 209
++++ H T+ E T G P+++ + +++ + + E R +E Q
Sbjct: 49 KKKINHGTNPETTTSGGCHSPEDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILT 108
Query: 210 -----------LSKDYARKAEELQ-ATYERENEAIRQAMQQS----VSQALWQWQEKESD 253
S+D ARK E+ T N A+ QA + S VS +L + K+
Sbjct: 109 CQKTELETALYYSQDAARKFEDGNLGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLA 168
Query: 254 LRKNFQVQESALQAQVRKLEGDLEHRGRKISDLKKYAQKLKERIQDLDVQLKEARQENSE 313
R + ++++ + R +K +Y ++L + L ++L N E
Sbjct: 169 GRLHHSWH---FAGELQRALSAVSTRHKKAD---RYIEELTKERDALSLELYRNTITNEE 222
Query: 314 LKGTAKKLGEKLAVAKDRMMLQECRGTQQTDAMKTELVSENKVLREENDLEAGNLHPQQD 373
LK +L EKL +A+ K+E+ K L+ + + A L PQ
Sbjct: 223 LKKKNAELQEKLPLAESE---------------KSEIQLNVKELKRKLE-RAKFLLPQVQ 266
Query: 374 QSCLKECPCMKGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVK--R 431
+ L+E +M ++E E E ++ EE + + + + E++ +++Q K R
Sbjct: 267 TNTLQE--------EMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWR 318
Query: 432 LEDLVKKHTVEIKSVRSSVEAERKKLQREVEAQLEEVRKKSEKEIKQLEEEKAALNVKLQ 491
E +++ E++ + E+K+L+ + E E+ K E+E K E+E+
Sbjct: 319 QEKRLREQEKELREQEKELR-EQKELREQEEQMQEQEEKMWEQEEKMREQEE-------- 369
Query: 492 NSLLEVLRLEEFIQQNKTRPTGAEESPQELGRQHCSILETQDPCLKLDETSPRGEEY--- 548
++ R EE + + + + E Q++ Q + E QD L+ E R +E
Sbjct: 370 ----KMWRQEERLWEQEKQ---MREQEQKMRDQEERMWE-QDERLREKEERMREQEKMWE 421
Query: 549 QDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQ 608
Q + EE ++E++T+ ++ + + ++E+ K++ EE + Q+ K+Q Q
Sbjct: 422 QVEKMREEKKMQEQEKKTRDQEEKMQEEER-----IREREKKMREEEETMREQEEKMQKQ 476
Query: 609 VSQMQQALEQCTSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMKAQLEA-SHQRAL 667
M + E+ R Q K E+EK+Q + ++ +Q ++ Q E ++ +
Sbjct: 477 EENMWEQEEKEWQQQRLPEQKEKLW---EQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKM 533
Query: 668 RMLEKARHQELKATEERLKKESSHSLQIQHQTHRLELQALEEKARQELQEERERMQAQQA 727
EK R QE + E+ K ++ Q R+E + E++ + QEE+ R + +
Sbjct: 534 WRQEKMREQEDQMWEQEEKMRDQEQ-KMWDQEERMEKKTQEQEKKTWDQEEKMREEERMR 592
Query: 728 LLLESLRQELSEQQAACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIATEERGGP 787
+ +R+E + Q+ E +Q + EE+
Sbjct: 593 EREKKMREEEEMMREQEEKMQEQEEKMQEQ------------------------EEK--- 625
Query: 788 GQAGSPPGAAGQGSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQ 847
+WE+ ++Q+ ++ + E+ ++ +K+ +Q+R E+ ++
Sbjct: 626 -------------------MWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEK 666
Query: 848 AQRAREVETLRQEHRKEMQAMVADFSSAQAQLQARLAALEAELKDSGEKPGKGASRPEDL 907
+++ + +E + + + Q Q + + ++++ + E+
Sbjct: 667 LWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEE 726
Query: 908 QLIGRLQTRLKEREDIIKQLTEE 930
+++ + +++E+E+ +++ EE
Sbjct: 727 EMMREQEEKMQEQEEKMQEQEEE 749
Score = 78.6 bits (192), Expect = 3e-14
Identities = 99/510 (19%), Positives = 216/510 (42%), Gaps = 75/510 (14%)
Query: 437 KKHTVEIKSVRSSVEAERKKLQREVEAQLEEVR----KKSEKEIKQLEEEKAALNVKLQN 492
+++ ++K + + ++ L+RE+EAQ +R +K+E E + AA + N
Sbjct: 73 QQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDGN 132
Query: 493 SLLEVLRLEEFIQQNKTRPTGA-------EESPQELGRQHCS---ILETQDPCLKLDETS 542
Q + P G ES GR H S E Q +
Sbjct: 133 LGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRALSAVSTRH 192
Query: 543 PRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLGSLLKEKTSKIQRLEEDWQSQK 602
+ + Y ++L E S E R + +E LK+K +++Q +S+K
Sbjct: 193 KKADRYIEELTKERDALSLELYRNTITNEE-----------LKKKNAELQEKLPLAESEK 241
Query: 603 AKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMKAQLEAS 662
+++Q V ++++ LE +A L ++ LQ E+ ++ + ++
Sbjct: 242 SEIQLNVKELKRKLE----------RAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQ 291
Query: 663 HQRALRMLEKARHQELKATEERLKKESSHSLQIQHQTHRLELQALEEKARQELQEERERM 722
++ R E+ R QE K E+ +K +++ Q L Q E + ++EL+E+ E+M
Sbjct: 292 EEKMWRQEERLREQEGKMREQE-EKMWRQEKRLREQEKELREQEKELREQKELREQEEQM 350
Query: 723 QAQQALLLESLRQELSEQQAACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIATE 782
Q Q+ + E +++ EQ+ ++ L + ++R + + + E
Sbjct: 351 QEQEEKMWEQ-EEKMREQEEKMWRQEERLWEQEKQMR-------------EQEQKMRDQE 396
Query: 783 ERGGPGQAGSPPGAAGQGSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFL 842
ER +WE++ +L++ R+R E E+ ++ +K+R++++ +
Sbjct: 397 ER----------------------MWEQDERLREKEERMR-EQEKMWEQVEKMREEKK-M 432
Query: 843 EETQQAQRAREVETLRQEHRKEMQAMVADFSSAQAQLQARLAALEAELKDSGEKPGKGAS 902
+E ++ R +E + +E +E + + + + + ++ E + + EK +
Sbjct: 433 QEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQR 492
Query: 903 RPEDLQLIGRLQTRLKEREDIIKQLTEERR 932
PE + + Q +++E+E+ I + E+ R
Sbjct: 493 LPEQKEKLWE-QEKMQEQEEKIWEQEEKIR 521
Score = 49.7 bits (117), Expect = 1e-05
Identities = 55/295 (18%), Positives = 126/295 (42%), Gaps = 33/295 (11%)
Query: 40 KKIAQLTKVIYALNTRQDEAEASMEALREA--HQEEL---QNAVAETKARLLQEQGCAEE 94
+K+ + + ++ + E E M E QEE Q + E K +L + + E+
Sbjct: 617 EKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQ 676
Query: 95 EALLQRIQALESALELQKRLTE--------EALAESASCRLETKERELRVEAEHAERVLT 146
E + ++ + + +++K+ E E + E S R +E+++R E E
Sbjct: 677 EKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMR--EREKKMREEEE------- 727
Query: 147 LSREMLELKADYERRLQHLTSHEATPQGRLPQESPETKSEPGQGPEMQEVLLEVQRLRVE 206
+ RE E + E ++Q E Q E E E + PE +E L E ++++ +
Sbjct: 728 MMREQEEKMQEQEEKMQE-QEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQ 786
Query: 207 NQQLSKDYARKAEELQATYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQ 266
+ ++ + +E + + E ++ + + +W +EK + QE +
Sbjct: 787 EKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMW 846
Query: 267 AQVRKLEGDLEHRGRKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKL 321
Q K+E ++ + +K++E+ + + Q ++ R++ +++G +K+
Sbjct: 847 GQEEKMEEKMQGQ----------EEKMREQEEKMRGQEEKMREQEEKMRGQEEKI 891
Score = 48.5 bits (114), Expect = 3e-05
Identities = 68/332 (20%), Positives = 134/332 (40%), Gaps = 33/332 (9%)
Query: 37 KMCKKIAQLTKVIYALNTRQDEAEASMEALREAHQEELQNAVAETKARLLQEQGCAEEEA 96
+M KK + K + + E E E ++ +EE E K + +E+ +EE
Sbjct: 566 RMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEK 625
Query: 97 LLQRIQALESALEL-----------------QKRLTE--EALAESASCRLETKERELRVE 137
+ ++ + ++ E Q+RL E E L E + + K +E +
Sbjct: 626 MWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEK 685
Query: 138 AEHAERVLTLSREMLELKADYERRLQHLTSHEATPQGRLPQESPETKSEPGQGPEMQEVL 197
E++ ++E + D E+ + + E + R +E + E Q E +E +
Sbjct: 686 IWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQ--EQEEKM 743
Query: 198 LEVQRLRVENQQLSKDYARKAEELQATYERENEAIRQAMQQSVSQALWQWQEKESDLRKN 257
E + E ++ + K E Q E + E + + + + +W+ +EK D +
Sbjct: 744 QEQEEEMWEQEEKMWEQEEKMWEQQRLPE-QKEKLWEHEKMQEQEKIWEQEEKMRDQEEK 802
Query: 258 FQVQESALQAQVRKLEGDLEHRGRKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGT 317
+ QE ++ Q K+ G E K + Q+ K Q+ + +E + E K
Sbjct: 803 MRGQEEKMRGQEEKMRGQEE---------KMWGQEEKMWGQEEKMWGQEEKMWGQEEKME 853
Query: 318 AKKLG--EKLAVAKDRMMLQECRGTQQTDAMK 347
K G EK+ +++M QE + +Q + M+
Sbjct: 854 EKMQGQEEKMREQEEKMRGQEEKMREQEEKMR 885
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 128 bits (321), Expect = 3e-29
Identities = 194/838 (23%), Positives = 336/838 (40%), Gaps = 127/838 (15%)
Query: 40 KKIAQLTKVIYALNTRQDE------AEASMEALREAHQEELQNAVAE-TKARLLQEQGCA 92
K+ L++ + AL T ++ A+ + RE EL+ A+ E TK Q Q
Sbjct: 1139 KQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMR 1198
Query: 93 EEEALLQRIQALESALELQKRLTEEALAESASCRLETKERELRVEAEHAERVLTLSREML 152
+ A ++ L LE KR +A E LET +EL E + ++V S
Sbjct: 1199 QRHATA--LEELSEQLEQAKRF--KANLEKNKQGLETDNKELACEVKVLQQVKAESEHK- 1253
Query: 153 ELKADYERRLQHLTSHEATPQG-RLPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLS 211
+ + ++Q L H +G RL E E S+ E+ V ++ + + +
Sbjct: 1254 --RKKLDAQVQEL--HAKVSEGDRLRVELAEKASKLQN--ELDNVSTLLEEAEKKGIKFA 1307
Query: 212 KDYARKAEELQATYERENEAIRQAMQQSV--------SQALWQWQEKESDLRKNFQVQES 263
KD A +LQ T E E RQ + S +L + QE+E + RKN + Q
Sbjct: 1308 KDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVL 1367
Query: 264 ALQAQV----RKLEGD------------------------LEHRGRKISDLKKYAQKLKE 295
ALQ+Q+ +K++ D LE + L+K +L++
Sbjct: 1368 ALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQ 1427
Query: 296 RIQDLDVQLKEARQENSELKGTAKKLGEKLAV--------------------AKDRMMLQ 335
+ DL V L RQ S L+ KK + LA K+ L
Sbjct: 1428 ELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALS 1487
Query: 336 ECRGTQQTDAMKTELVSENKVLREE-------NDLEAGNLHPQQDQSCLKECPCMKGGTD 388
R ++ K E +NK LR + D N+H + E + T
Sbjct: 1488 LARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQ 1547
Query: 389 MQTKKEASAETE-----------YMKQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDLVK 437
++ ++ TE MK Q+E DL+ Q EE+K+ L+K++ +L
Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKR----LLIKQVRELEA 1603
Query: 438 KHTVEIKSVRSSVEAERKKLQ---REVEAQLEEVRKKSEKEIKQLEEEKAALNVKLQNSL 494
+ E K R+ A +KK++ +++EAQ+E K ++ IKQL KLQ +
Sbjct: 1604 ELEDERKQ-RALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLR--------KLQAQM 1654
Query: 495 LEVLR-LEEFIQQNKTRPTGAEESPQELGRQHCSILETQDPCLKLDETSPRGEEYQDKLA 553
+ R LEE ++ES ++L IL+ Q+ + E+ +D+LA
Sbjct: 1655 KDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELA 1714
Query: 554 AEEGTSS-------DEEERTK---VLLKEGSDPQPPLGSLLKEKTSKIQRLEEDWQSQKA 603
E S+ DE+ R + L+E + + LL ++ K + ++ A
Sbjct: 1715 DEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELA 1774
Query: 604 KLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMKAQL--EA 661
++ + A +Q +E L++L + K + + + ++ QL EA
Sbjct: 1775 AERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEA 1834
Query: 662 SHQRALRMLEKARHQELKATEERLKKESSHSLQIQHQTHRLELQALEEKAR-QELQEERE 720
+ A L + ++LK +++ E H+ Q + Q + + + K + +E +EE
Sbjct: 1835 KERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEAT 1894
Query: 721 RMQAQQALLLESLRQELSEQQAACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHI 778
R A + L++EL + A G +++ L+ LR G SS G + H+
Sbjct: 1895 RANASR----RKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLHL 1948
Score = 118 bits (295), Expect = 3e-26
Identities = 192/902 (21%), Positives = 382/902 (42%), Gaps = 161/902 (17%)
Query: 110 LQKRLTEEALAESASCRLETKERELRVEAEHAERVLTLSREMLELKADYERRLQHLTSHE 169
LQ EE L L+ KE++ +VE E E + +++LE K +LQ T
Sbjct: 845 LQVTRQEEELQAKDEELLKVKEKQTKVEGE-LEEMERKHQQLLEEKNILAEQLQAETE-- 901
Query: 170 ATPQGRLPQESPETKSE-PGQGPEMQEVLLEVQRLRVENQQLSKDYARKAEELQATYERE 228
L E+ E ++ + E++E+L +++ +R EE + +
Sbjct: 902 ------LFAEAEEMRARLAAKKQELEEILHDLE-------------SRVEEEEERNQILQ 942
Query: 229 NEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLE--------------- 273
NE ++ MQ + Q L + ++E R+ Q+++ +A+++K+E
Sbjct: 943 NE--KKKMQAHI-QDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIK 999
Query: 274 -------------GDLEHRGRKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKK 320
L K +L K K + I DL+ +LK+ + EL+ +K
Sbjct: 1000 EKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRK 1059
Query: 321 L-GE------------------KLAVAKDRMMLQE--CRGTQQT----DAMKT--ELVSE 353
L GE KL +AK LQ RG +T +A+K EL ++
Sbjct: 1060 LDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQ 1119
Query: 354 NKVLRE--ENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEASAETEYMKQQYEEDLR 411
L+E E++ + N +Q + +E +K T+++ + +A + ++ + E+++
Sbjct: 1120 IAELQEDFESEKASRNKAEKQKRDLSEELEALK--TELEDTLDTTAAQQELRTKREQEVA 1177
Query: 412 KIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVE-AERKKLQREVEAQ-LEEVR 469
++K EEE K+ + Q ++D+ ++H ++ + +E A+R K E Q LE
Sbjct: 1178 ELKKALEEETKNHEAQ----IQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDN 1233
Query: 470 KKSEKEIKQLEEEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEESPQELGRQHCSIL 529
K+ E+K L++ KA K + +V L + + E +L
Sbjct: 1234 KELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQN------ 1287
Query: 530 ETQDPCLKLDETSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLGS---LLKE 586
E + L+E +G ++ A+ E D +E LL+E + + L S L+E
Sbjct: 1288 ELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQE----LLQEETRQKLNLSSRIRQLEE 1343
Query: 587 KTSKIQRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQRELQ 646
+ + +Q +E+ + + L+ QV +Q L +DL ++ L + ++KL ++ +
Sbjct: 1344 EKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEE-AKKKLLKDAE 1402
Query: 647 ETTQQNHAMKAQLEASHQRALRMLEKA-RHQELKATEERLKKE-SSHSLQIQHQTHRLEL 704
+Q R+ EKA + +L+ T+ RL++E ++ + HQ
Sbjct: 1403 ALSQ-----------------RLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASN 1445
Query: 705 QALEEKARQELQEERERMQAQQALLLESLRQELSEQQAACSGHQKDL-EALQAELRALGR 763
++K +L E + + A+ A + E E++ + L EAL+A+
Sbjct: 1446 LEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEF--- 1502
Query: 764 QQASSQCPGDSKDHIIATEERGGPGQAGSPPGAAGQGSGEGCGLWEENAQLQDAVRRLRA 823
++ + Q D +D + + ++ G+ E L + L+ V +R
Sbjct: 1503 ERQNKQLRADMEDLMSSKDD-------------VGKNVHE---LEKSKRALEQQVEEMRT 1546
Query: 824 EVEQHQQEAQKLRDQRRFLEETQQAQRA---REVETLRQEHRKEMQAMVADFSSAQAQLQ 880
++E+ + E Q D + LE QA +A R+++T +++ ++ + ++ +A+L+
Sbjct: 1547 QLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELE 1606
Query: 881 ----------ARLAALEAELKD-SGEKPGKGASRPEDLQLIGRLQTRLKEREDIIKQLTE 929
A +E +LKD + +R E ++ + +LQ ++K D ++L E
Sbjct: 1607 DERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMK---DYQRELEE 1663
Query: 930 ER 931
R
Sbjct: 1664 AR 1665
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 128 bits (321), Expect = 3e-29
Identities = 204/992 (20%), Positives = 419/992 (42%), Gaps = 149/992 (15%)
Query: 36 VKMCKKIAQ--------LTKVIYALNTRQDEAEASMEALREAHQEELQNAVAETK----- 82
+K CK+ Q LT AL + DE +E +++ H E + + +
Sbjct: 295 LKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNL 354
Query: 83 -ARLLQEQGCAEEEALLQRIQALESALE--LQKRLTEEALAESASCRLETKERELRVEAE 139
+L Q++G E Q + LE E Q R + + E KE+ R E
Sbjct: 355 IEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFE 414
Query: 140 HAERVLTLSREMLE----LKADYERRLQHLTSHEATPQGRLPQESPETKSE--PGQGPEM 193
E+ L+ +++ E LKA+ + +++ + + L QE K E
Sbjct: 415 ELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSS 474
Query: 194 QEVLLEVQRLRVENQQLSKDYARKAEELQA---TYERE-NEAIRQAMQQSVSQALWQWQE 249
+E + ++Q+L K+ ARK +EL T ERE E ++ A+++S S+ L QE
Sbjct: 475 EEQIAKLQKLH------EKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQE 528
Query: 250 KESDLRKNFQVQESALQAQVRKLEGDLEHRGRKISDLKKYAQKLKERIQDLDVQLKEARQ 309
KE +++ ++E LQ + E + K+ DL++ A+ + RI +L+ L+++ Q
Sbjct: 529 KEQ--QESLALEELELQKKAILTESE-----NKLRDLQQEAETYRTRILELESSLEKSLQ 581
Query: 310 ENSE--------LKGTAKKLGEKLAVAKDRMML--------QECRGTQQTDAMKTELVSE 353
EN L+ K +++ V ++ Q+ T++ +K + +E
Sbjct: 582 ENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTE 641
Query: 354 NKVLREENDLEAGNLHPQQD-----------QSCLKECPCMKGGTDMQTKKEASAETEYM 402
+ LRE+ + E L ++ + L++ + T++++ +E
Sbjct: 642 MEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQ--TELESLSSELSEVLKA 699
Query: 403 KQQYEEDLRKIKHQTEEEKKHL-------KDQLVKRLEDLVKKHTVEIKSVRSSVE---- 451
+ + EE+L +K QT++ K+ L K+ ++++ ++K+H V I+ +++
Sbjct: 700 RHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQIN 759
Query: 452 ------AERKKLQREVEAQLEEVRKKSEKEIKQLEEEKAALNV--KLQNSLLEVLRL-EE 502
ER K +E +A +E + ++ +L++ A L+V Q++ E + EE
Sbjct: 760 QLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEE 819
Query: 503 FIQQNKTRPTGAEESPQELGRQHCSI-LETQDPCLKLDETSPRGEEYQDKLAAEEGTSSD 561
+ Q + + E L +Q + + +D C +LD + QD + E +S+
Sbjct: 820 QLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKI---QVQDLMQQLEKQNSE 876
Query: 562 EEERTKVL-------LKEGSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQQ 614
E++ K L L++G+ Q +L EK + I ++ E + + L ++S +
Sbjct: 877 MEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKED 936
Query: 615 AL-------EQCTSNYREDLQALKQLSDLEREKLQREL--QETTQQNHAMKAQLEASHQR 665
++ E N + ++ +KQ + +E L+++L QE + LE S +
Sbjct: 937 SIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKE 996
Query: 666 A---LRMLEKARHQELKATEERLKKESSHSLQIQHQT--HRLELQALEEKARQELQEERE 720
+MLE A+ ++ + E++ QI+ T HR EL + ++L ++ E
Sbjct: 997 KQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAE 1056
Query: 721 RMQAQQALLLESLRQELSE--QQAACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHI 778
+Q + L+ QE++E Q+ G +K E + E+ L + +
Sbjct: 1057 ELQEIHEIQLQEKEQEVAELKQKILLFGCEK--EEMNKEITWLKEEGVKQDTTLNELQEQ 1114
Query: 779 IATEERGGPGQAGSPPGAAGQGSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQ 838
+ + N+ QD +L+A +E+ + + K +
Sbjct: 1115 LKQKSA------------------------HVNSLAQDET-KLKAHLEKLEVDLNKSLKE 1149
Query: 839 RRFLEETQQAQRAREVETLRQEHRKEMQAMVADFSSAQAQLQARLAALEAELKDSGEKPG 898
FL+E + E++ L +E ++++ + + + + Q+ ++ E K +K
Sbjct: 1150 NTFLQE-----QLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSL 1204
Query: 899 KGASRPEDLQLIGRLQTRLKEREDIIKQLTEE 930
+ E+L + +L K+ E +++ T E
Sbjct: 1205 EFKKLSEELAI--QLDICCKKTEALLEAKTNE 1234
Score = 114 bits (285), Expect = 5e-25
Identities = 200/961 (20%), Positives = 388/961 (40%), Gaps = 161/961 (16%)
Query: 38 MCKKIAQLTKVIYALNTRQDEAEASMEALREAHQEELQNAVAETKARLLQEQGCAEEEAL 97
+ +K++ I+ LN + + E E +++ + K +LL ++ ++E
Sbjct: 927 LTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELE 986
Query: 98 LQRIQALESALELQKRLTEEALAESASC-----RLETKERELRVEAEHAERVLTLSREML 152
++ + + ++ E A A SA RLET ++E R RE+
Sbjct: 987 NTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHR-----RELN 1041
Query: 153 ELKADYERRLQHLTSHEATPQGRLPQESPETKSEPGQ-----GPEMQEVLLEVQRLRVEN 207
++ + +E++L QE + +E Q G E +E+ E+ L+ E
Sbjct: 1042 DVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEG 1101
Query: 208 QQLSKDYARKAEELQATYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQA 267
+ E+L ++ A ++ Q ++ ++ E DL K+ + + + LQ
Sbjct: 1102 VKQDTTLNELQEQL-----KQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLK-ENTFLQE 1155
Query: 268 QVRKLEGDLEHRGRKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAV 327
Q+ +L+ E RK+S+L + E Q L +++ + + KKL E+LA+
Sbjct: 1156 QLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAI 1215
Query: 328 AKDRMMLQECRGTQQTDAMKT-ELVSENKVLREENDLEAGNLHPQQDQSCLKECPCMKGG 386
D C+ T+ KT EL++ + + N + + H Q + +KE +K
Sbjct: 1216 QLDIC----CKKTEALLEAKTNELINISS--SKTNAILSRISHCQHRTTKVKEALLIKTC 1269
Query: 387 TDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEEKKHLK------DQLVKRLEDLVKKHT 440
T + + + TE + ++ HQ EE++ +K + LV E L K+
Sbjct: 1270 TVSELEAQLRQLTEE-QNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGG 1328
Query: 441 VEIKSV---RSSVEAERKKLQREVEAQ--LEEVRKKSEKEIKQLEEEKAALNVKLQNSL- 494
+ ++ S + +K+L + A ++E K+ + EI L ++ LNV+LQNS+
Sbjct: 1329 NQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSIS 1388
Query: 495 -----LEVLRLEEFIQQNKTRPTGAEES----PQELGRQHCSILETQDPCL-KLDETSPR 544
+ L + + K + L ++ S LE D K E +
Sbjct: 1389 LSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKK 1448
Query: 545 GE-------------EYQDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLGSLLK----EK 587
+ + Q +L ++E DE+ LLKE D Q LK +
Sbjct: 1449 AQSRFTQHQNTVKELQIQLELKSKEAYEKDEQIN---LLKEELDQQNKRFDCLKGEMEDD 1505
Query: 588 TSKIQRLEEDWQSQKAKLQAQVSQMQQALEQCT---SNYREDLQALKQLSDLEREKLQRE 644
SK+++ E + +++ A++ +++ + Q T + E L+ Q D+E ++L ++
Sbjct: 1506 KSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQK 1565
Query: 645 LQETTQ---------------------QNHAMKAQLEASHQRA--LRMLEKARHQELKAT 681
LQ + Q ++MKA+LE + + + K++ +ELKA
Sbjct: 1566 LQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKAL 1625
Query: 682 EERLKKESSHSLQIQHQTHRLELQALEEKARQELQEERERMQAQQALLLESLRQELSEQQ 741
E+RL+ ES+ L + ++ A++++ +++E+ E+ + L L +L E+
Sbjct: 1626 EDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQER- 1684
Query: 742 AACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGAAGQGS 801
++++ L+ +L+++ Q+ + S ++ A E
Sbjct: 1685 ------EREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTE------------------ 1720
Query: 802 GEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQR-AREVETLRQE 860
+E A Q V Q+ + E+ QR E E L Q
Sbjct: 1721 -------QEEADSQGCV-------------------QKTYEEKISVLQRNLTEKEKLLQR 1754
Query: 861 HRKEMQAMVADFSSAQAQLQARLAALE-AELKDSGEKPGKGASRPEDLQLIGRLQTRLKE 919
+E + V+ + Q Q RL LE AE A + ED +IG LQ L+E
Sbjct: 1755 VGQEKEETVSSHFEMRCQYQERLIKLEHAE-----------AKQHEDQSMIGHLQEELEE 1803
Query: 920 R 920
+
Sbjct: 1804 K 1804
Score = 108 bits (270), Expect = 3e-23
Identities = 175/884 (19%), Positives = 379/884 (42%), Gaps = 127/884 (14%)
Query: 94 EEALLQRIQALESALELQKRLTEEALAESASCRLETKERELRVEAEHAERVLTLSREMLE 153
++ L+RI L L++ ++ ++ L E LE K++ + V + ++L ++ L
Sbjct: 182 QDKSLRRIAELREELQMDQQ-AKKHLQEEFDASLEEKDQYISV----LQTQVSLLKQRLR 236
Query: 154 LKADYERRLQHLTSHEATPQGRLPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLSKD 213
L+ L E + +E+PE+ EP LE + RV+ Q+ +
Sbjct: 237 NGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQE---N 293
Query: 214 YARKAEELQATYERENEAI---RQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVR 270
++ +E +++ + + ++A+Q+ + + L Q EK DL +++ L Q+R
Sbjct: 294 LLKRCKETIQSHKEQCTLLTSEKEALQEQLDERL-QELEKIKDLH---MAEKTKLITQLR 349
Query: 271 KLEGDLEH----RGRKISDLKKYAQKL----KERIQDLDVQLKEARQENSELKGTAKKLG 322
+ +E +G I++ K+ + +E I L ++K+ + EL+ +K
Sbjct: 350 DAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEK-S 408
Query: 323 EKLAVAKDRMMLQECRGTQQTDA-MKTELVSENKVLREENDLEAGNLHPQQDQSCLKECP 381
E+ A + L + T++ +K E+ + K + + ++ E +L QQ+ S +K+
Sbjct: 409 ERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISL--QQELSRVKQ-- 464
Query: 382 CMKGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDLVKKHTV 441
+ MK+ EE + K++ E+E + +L K+L+ ++
Sbjct: 465 ---------------EVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQE 509
Query: 442 EIKSVRSSVEAERKKLQREVEAQ----LEE-------VRKKSEKEIKQLEEEKAALNVKL 490
++K ++E K+ +E E Q LEE + +SE +++ L++E +
Sbjct: 510 QMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTR- 568
Query: 491 QNSLLEV-LRLEEFIQQNKTRPTG------AEESPQ--------ELGRQHCSILETQDPC 535
+LE+ LE+ +Q+NK + AE++ E + L+ Q
Sbjct: 569 ---ILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDA 625
Query: 536 LKLDETSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLGSLLKEKTSKIQRLE 595
L ++ ++YQ ++ E E+ + LLK D + + ++E K
Sbjct: 626 LWTEKLQVLKQQYQTEM---EKLREKCEQEKETLLK---DKEIIFQAHIEEMNEKTLEKL 679
Query: 596 EDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQRELQETTQQNHAM 655
+ Q++ L +++S++ +A + E+L LK +D +++L+ ++ E +
Sbjct: 680 DVKQTELESLSSELSEVLKARHK----LEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQ 735
Query: 656 KAQLEASHQRALRMLEKARHQELKATEERLKKESSHSLQIQHQTHRLELQALEEKARQEL 715
+ H+ +++ EKA ++ E LK+ H +HQ H L+A +++ EL
Sbjct: 736 VDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLK--EHQAHVENLEADIKRSEGEL 793
Query: 716 QEERERMQAQQALLLESLRQELSEQQAACSGHQKDLEALQAELRALGRQQASSQCPGDSK 775
Q+ ++ Q+ + Q + ++ QK L+ L+ E L +Q A + K
Sbjct: 794 QQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLD-LETERILLTKQVA--EVEAQKK 850
Query: 776 DHIIATEERGGPGQAGSPPGAAGQGSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQ-- 833
D + TE L Q+QD +++L + + +Q+ +
Sbjct: 851 D--VCTE------------------------LDAHKIQVQDLMQQLEKQNSEMEQKVKSL 884
Query: 834 ------KLRDQRRFLEETQQ--AQRAREVETLRQEHRKEMQAMVADFSSAQAQLQARLAA 885
KL D + E+T+Q ++ + +R+ +KE++ + S+ + +
Sbjct: 885 TQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEE 944
Query: 886 LEAELKDSGEKPGKGASRPEDLQLIGRLQTRLKEREDIIKQLTE 929
E + K+ +K K + +++Q L+ +L ++E +K+ E
Sbjct: 945 YETKFKNQEKKMEKVKQKAKEMQ--ETLKKKLLDQEAKLKKELE 986
Score = 92.8 bits (229), Expect = 2e-18
Identities = 198/986 (20%), Positives = 412/986 (41%), Gaps = 155/986 (15%)
Query: 40 KKIAQLTKVIYALNTRQDEAEASMEALREAHQEELQNAVAETKARLLQEQGCAEEEALLQ 99
+K+++LT + DE S+++ E + L++ E K L E+ + + +
Sbjct: 1169 RKVSELTSKLKTT----DEEFQSLKSSHEKSNKSLEDKSLEFKK--LSEELAIQLDICCK 1222
Query: 100 RIQALESALELQKRLTEEALAESASCRLETKERELRVEAEHAERVLTLSREMLELK---- 155
+ +AL A T E + S+S K + H + T +E L +K
Sbjct: 1223 KTEALLEAK------TNELINISSS-----KTNAILSRISHCQHRTTKVKEALLIKTCTV 1271
Query: 156 ADYERRLQHLTSHEATPQGRLPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYA 215
++ E +L+ LT + T Q + + + + Q M+ +++ L E + L K+
Sbjct: 1272 SELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKA---DIESLVTEKEALQKE-- 1326
Query: 216 RKAEELQATYEREN--EAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLE 273
+ QA E+E+ +++ + ++++ +E K +V+ S+L Q+ L
Sbjct: 1327 -GGNQQQAASEKESCITQLKKELSENINAVTLMKEEL-----KEKKVEISSLSKQLTDLN 1380
Query: 274 GDLEH------RGRKISDLKKYAQKLK----ERIQDLDVQLKEARQENSELKGTAKKLGE 323
L++ + IS L+K + K +++QDL ++ +E
Sbjct: 1381 VQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSN 1440
Query: 324 KLAVAKDRMMLQECRGTQQTDAMKTELVSENKVLREENDLEAGNLHPQQDQSCLKECPCM 383
K + K + + R TQ + +K L+ + +L++ + + +Q L +
Sbjct: 1441 KFSEWKKKA---QSRFTQHQNTVKE--------LQIQLELKSKEAYEKDEQINL-----L 1484
Query: 384 KGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVK--RLEDLVKKHTV 441
K D Q K+ + +K + E+D K++ + + LK Q + LED + + T+
Sbjct: 1485 KEELDQQNKR-----FDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTI 1539
Query: 442 EIKSVRSSV-------EAERKKLQREVEAQLEEVRKKSEKEIKQLEEEKAALNVKLQNSL 494
EI+S+ + + E K+L ++++ +E+ ++ + +K+ EE+ L ++ +
Sbjct: 1540 EIESLNEVLKNYNQQKDIEHKELVQKLQ-HFQELGEEKDNRVKEAEEKILTLENQVYSMK 1598
Query: 495 LEVLRLEEFIQQNKTRPTGAEESPQELGRQHCSILETQDPCLKLDETSPRGEEYQDKLAA 554
E+ ++ ++ EE + L + LE++ KL E + E+ K+AA
Sbjct: 1599 AELETKKKELEHVNLSVKSKEEELKALEDR----LESESAA-KLAELKRKAEQ---KIAA 1650
Query: 555 EEGTSSDEEERTKVLLKEGSDPQ-PPLGSLLKEKTSKIQRLEEDWQS------------Q 601
+ + E + K+G++ L + L+E+ ++ LEE +S +
Sbjct: 1651 IKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPR 1710
Query: 602 KAKLQAQVSQMQQALEQ-CTSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMKAQLE 660
AK A ++ ++A Q C E+ ++ Q + E+EKL + + + ++ + ++
Sbjct: 1711 SAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMR 1770
Query: 661 ASHQRALRMLEKA---RHQELKAT----EERLKKESSHSLQIQHQTHRLELQALEEKARQ 713
+Q L LE A +H++ EE +K +SL + + E +A+Q
Sbjct: 1771 CQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEK-EGGKNNIQAKQ 1829
Query: 714 ELQ---EERERMQAQQALLLESLRQELSEQQAACSGHQKDLEALQAE--------LRAL- 761
L+ ++ ++ ++ L + L Q++ E + C QK++ ++ E L+AL
Sbjct: 1830 NLENVFDDVQKTLQEKELTCQILEQKIKELDS-CLVRQKEVHRVEMEELTSKYEKLQALQ 1888
Query: 762 ---GRQQASSQCPGD----SKDHIIATEERGG-PGQAGSPPGAAGQGSGEGCGLWEENAQ 813
GR + + + SK H++ + Q E L +E +
Sbjct: 1889 QMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVR 1948
Query: 814 LQDAVRRLRAEVEQH---------QQEAQKLRDQRRFLE--------------ETQQAQR 850
LQ +R LR E +Q Q+ +K++ ++ LE TQ AQ+
Sbjct: 1949 LQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQK 2008
Query: 851 AREVETLRQEHRKEMQAMVADFSSAQAQLQARLAALEAELKDSGEKPGK------GASRP 904
+E+E +E + Q + A+ + + +L AE D ++ K A
Sbjct: 2009 EQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREE 2068
Query: 905 EDLQLIGRLQTRLKEREDIIKQLTEE 930
E + LQT+L+E + +Q E+
Sbjct: 2069 EMTAKVRDLQTQLEELQKKYQQKLEQ 2094
Score = 80.5 bits (197), Expect = 8e-15
Identities = 157/782 (20%), Positives = 344/782 (43%), Gaps = 99/782 (12%)
Query: 16 QGSKADGGAGWRMDCDPQMHVKMCKKIAQLTKVIYALNTRQDEAEASMEALREAHQEELQ 75
+G A + C Q+ ++ + I +T + L ++ E + + L + + + LQ
Sbjct: 1326 EGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQ-LQ 1384
Query: 76 NAVA----ETKARLLQEQGCAEEEALLQRIQALE---SALELQKRLTEEALAESASCRLE 128
N+++ E L++Q E+ LL ++Q L L +K E + + ++ E
Sbjct: 1385 NSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSE 1444
Query: 129 TKERELRVEAEHAERVLTLSREM-LELKADYERRLQ-HLTSHEATPQGR----LPQESPE 182
K++ +H V L ++ L+ K YE+ Q +L E Q + L E +
Sbjct: 1445 WKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMED 1504
Query: 183 TKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYARKAEELQATYERENEAIRQAMQQS--- 239
KS+ + E L+ Q R+ +L +K E+++ NE ++ QQ
Sbjct: 1505 DKSKMEKKESNLETELKSQTARI--MELEDHITQKTIEIESL----NEVLKNYNQQKDIE 1558
Query: 240 ---VSQALWQWQE--KESDLR-KNFQVQESALQAQVRKLEGDLEHRGRKISDLKKYAQKL 293
+ Q L +QE +E D R K + + L+ QV ++ +LE + +++ + +
Sbjct: 1559 HKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSK 1618
Query: 294 KERIQDLDVQLK-EARQENSELKGTAKKLGEKLAVAKDRMMLQ-ECRGTQQTDAMKTELV 351
+E ++ L+ +L+ E+ + +ELK +K +K+A K +++ Q E + Q ++ L
Sbjct: 1619 EEELKALEDRLESESAAKLAELK---RKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLS 1675
Query: 352 SENKVL----REENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEASAETEYMKQQYE 407
N L RE + LE + QS P T++E + +++ YE
Sbjct: 1676 ELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYE 1735
Query: 408 EDLRKIKHQTEEEKKHLKDQLVKRLEDLVKKH----------TVEIKSVRSSVEAERKKL 457
E + ++ E++K L+ ++ + E+ V H ++++ + + E + +
Sbjct: 1736 EKISVLQRNLTEKEKLLQ-RVGQEKEETVSSHFEMRCQYQERLIKLEHAEAK-QHEDQSM 1793
Query: 458 QREVEAQLEEVRKKSEKEIKQ-LEEEKAALNVKLQNSLLEVLR-LEEFIQQNKTRPTGAE 515
++ +LEE KK + Q +E+E N++ + +L V +++ +Q+ + E
Sbjct: 1794 IGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILE 1853
Query: 516 ESPQELGRQHCSILETQDPCLKLDETSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSD 575
+ +EL C + + + ++++E + + E+ Q L +G + E LL+E ++
Sbjct: 1854 QKIKEL--DSCLVRQKEVHRVEMEELTSKYEKLQ-ALQQMDGRNKPTE-----LLEENTE 1905
Query: 576 PQPPLGSLLKEKTSKIQ-RLEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLS 634
K K+ +Q +L + ++Q L+ +++ ++
Sbjct: 1906 E--------KSKSHLVQPKLLSNMEAQHNDLEFKLAGAER-------------------- 1937
Query: 635 DLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLEK----ARHQELKATEERLKKESS 690
E++KL +E+ + ++ + HQ+ L +L+K R +++K +E L+ + +
Sbjct: 1938 --EKQKLGKEIVRLQKDLRMLRKE----HQQELEILKKEYDQEREEKIKQEQEDLELKHN 1991
Query: 691 HSLQIQHQTHRLELQALEEKARQELQEERERMQAQQALLLESLRQELSEQQAACSGHQKD 750
+L+ + +L E++ ++E + Q +A LLES ++E ++ + D
Sbjct: 1992 STLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDD 2051
Query: 751 LE 752
L+
Sbjct: 2052 LK 2053
Score = 73.6 bits (179), Expect = 1e-12
Identities = 143/673 (21%), Positives = 277/673 (41%), Gaps = 96/673 (14%)
Query: 41 KIAQLTKVIYALNTRQD-EAEASMEALREAHQ--EELQNAVAETKARLLQEQGCAEEEAL 97
+I L +V+ N ++D E + ++ L+ + EE N V E + ++L L
Sbjct: 1540 EIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKIL---------TL 1590
Query: 98 LQRIQALESALELQKRLTEEALAESASCRLETKERELRVEAEHAERVLTLSREMLELKAD 157
++ ++++ LE +K+ E S E K E R+E+E A ++ L R+ + A
Sbjct: 1591 ENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAA 1650
Query: 158 YERRLQHLTSHEATPQGRLPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYARK 217
+++L + + + + Q E + +LE + VE+ Q +
Sbjct: 1651 IKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPR 1710
Query: 218 AEELQATYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLE 277
+ + A Y + EA Q Q ++EK S L++N +E LQ ++ E
Sbjct: 1711 SAKNVAAYTEQEEADSQGCVQKT------YEEKISVLQRNLTEKEKLLQRVGQEKE---- 1760
Query: 278 HRGRKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEK-----LAVAKDRM 332
+S + + +ER+ L+ + ++ S + ++L EK L VA+
Sbjct: 1761 ---ETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQH-- 1815
Query: 333 MLQECRGTQQTDAMKTELVSENKVLREENDLEAGNLHPQQDQSCLKECP-CMKGGTDMQT 391
E G + K L EN + L+ L Q + +KE C+ ++
Sbjct: 1816 --VEKEGGKNNIQAKQNL--ENVFDDVQKTLQEKELTCQILEQKIKELDSCL-----VRQ 1866
Query: 392 KKEASAETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVE 451
K+ E E + +YE+ L+ ++ K + L + E+ K H V+ K + S++E
Sbjct: 1867 KEVHRVEMEELTSKYEK-LQALQQMDGRNKP--TELLEENTEEKSKSHLVQPKLL-SNME 1922
Query: 452 AERKKLQREVEAQLEEVRKKSEKEIKQLEEEKAALNVKLQNSLLEVLRLEEFIQQNKTRP 511
A+ L+ ++ A E ++K KEI +L+++ L + Q L E+L+ E ++ R
Sbjct: 1923 AQHNDLEFKL-AGAEREKQKLGKEIVRLQKDLRMLRKEHQQEL-EILKKE----YDQERE 1976
Query: 512 TGAEESPQELGRQHCSILET-------------QDPCLKLDETSPRGEEYQDKLAAEEGT 558
++ ++L +H S L+ Q+ + + ET + +E + +L
Sbjct: 1977 EKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELL----- 2031
Query: 559 SSDEEERTKVLLKEGSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQQALEQ 618
+E T LLK+ ++ L K + EE+ ++ LQ Q+ ++Q+ +Q
Sbjct: 2032 -ESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQ 2090
Query: 619 CTSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLEKARHQEL 678
KL++E M+ Q + + + L K + QE
Sbjct: 2091 ---------------------KLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEF 2129
Query: 679 KA----TEERLKK 687
+ E+RLKK
Sbjct: 2130 REQIHNLEDRLKK 2142
Score = 69.3 bits (168), Expect = 2e-11
Identities = 114/517 (22%), Positives = 214/517 (41%), Gaps = 83/517 (16%)
Query: 40 KKIAQLTKVIYALNTRQDEAEASMEALREAHQEELQNAVAETK--ARLLQEQGCAEEEAL 97
+KIA + K L ++ +E E + E+H EL + E + +L+E+ + E +
Sbjct: 1646 QKIAAIKK---QLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQ 1702
Query: 98 LQRIQALESALELQKRLTEEALAESASCRLETKERELRVEAEHAERVLTLSREML----- 152
+ + SA + TE+ A+S C +T E ++ V +R LT ++L
Sbjct: 1703 SETLIVPRSAKNVAA-YTEQEEADSQGCVQKTYEEKISV----LQRNLTEKEKLLQRVGQ 1757
Query: 153 ----------ELKADYERRLQHLTSHEATPQ------GRLPQESPE------------TK 184
E++ Y+ RL L EA G L +E E +
Sbjct: 1758 EKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVE 1817
Query: 185 SEPGQG-----PEMQEVLLEVQRLRVENQQLSKDYARKAEELQATYERENEAIRQAMQQS 239
E G+ ++ V +VQ+ E + + +K +EL + R+ E R M++
Sbjct: 1818 KEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEEL 1877
Query: 240 VSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEHRGRKISDLKKYAQKLKERIQD 299
S+ EK L+ Q LE + E + + K ++ + D
Sbjct: 1878 TSK-----YEKLQALQ-----QMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHND 1927
Query: 300 LDVQLKEARQENSELKGTAKKLGEKLA-VAKDRMMLQECRGTQQTDAMKTELVSEN--KV 356
L+ +L A +E +KLG+++ + KD ML++ Q+ + +K E E K+
Sbjct: 1928 LEFKLAGAEREK-------QKLGKEIVRLQKDLRMLRK-EHQQELEILKKEYDQEREEKI 1979
Query: 357 LREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEASAET---EYMKQQYEEDLRKI 413
+E+ DLE + S LK+ M+ +KE E E + + E + +
Sbjct: 1980 KQEQEDLEL------KHNSTLKQL--MREFNTQLAQKEQELEMTIKETINKAQEVEAELL 2031
Query: 414 KHQTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERKKLQREVEAQLEEVRKKSE 473
+ EE + LK + +D +K+ + + + E E R+++ QLEE++KK +
Sbjct: 2032 ESHQEETNQLLKK--IAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQ 2089
Query: 474 KEIKQLEEEKAALNVKLQNSLLEVLRLEEFIQQNKTR 510
++++Q EE NV + ++ + I +K +
Sbjct: 2090 QKLEQ-EENPGNDNVTIMELQTQLAQKTTLISDSKLK 2125
Score = 64.3 bits (155), Expect = 6e-10
Identities = 114/532 (21%), Positives = 217/532 (40%), Gaps = 47/532 (8%)
Query: 422 KHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERKKLQREVEAQLEEVRKKSEKEIKQLEE 481
K LK ++ + + L + S SS + QL+E E Q
Sbjct: 3 KKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFA 62
Query: 482 EKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEESPQELGRQHCSILETQDPCLKLDET 541
+K L V SL I+++ R + E + R+ + L+ D
Sbjct: 63 QKLQLRVPSVESLFR-----SPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPP 117
Query: 542 SPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLGSLLKEKTSKIQRLEEDWQSQ 601
S E +D + + + ++ L++ + L S + K S++ + Q +
Sbjct: 118 SDMDSEAEDLVGNSDSLNKEQ------LIQRLRRMERSLSSY-RGKYSELVTAYQMLQRE 170
Query: 602 KAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMKAQLEA 661
K KLQ +SQ Q + + RE+LQ +Q +E+ L+E Q ++ Q+
Sbjct: 171 KKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSL 230
Query: 662 SHQR---------ALRMLEKARHQELKATEERLKKESSHSLQIQHQTHRLELQALEEKAR 712
QR L+ L + Q T+E ES ++ T L+ L+++ +
Sbjct: 231 LKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEE-NPESDGEPVVEDGTSVKTLETLQQRVK 289
Query: 713 QE---LQEERERMQA--QQALLLESLRQELSEQQAACSGHQKDLEALQAELRALGRQQAS 767
++ L+ +E +Q+ +Q LL S ++ L EQ ++LE ++ +L + +
Sbjct: 290 RQENLLKRCKETIQSHKEQCTLLTSEKEALQEQ---LDERLQELEKIK-DLHMAEKTKLI 345
Query: 768 SQCPGDSKDHIIATEERGGPGQAGSPPGAAGQGSGEGCGLWEEN-AQLQDAVRRLRAEVE 826
+Q D+K+ I E+ G + E + EE AQL+ ++++ + E
Sbjct: 346 TQL-RDAKNLIEQLEQ-----DKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGE 399
Query: 827 QHQQEAQKLRDQRRFLEETQQA-QRAREVETLRQEHRKEMQAMVADFSSAQAQ----LQA 881
+ ++ QK + +R EE ++A A++ E R++ + EM + + LQ
Sbjct: 400 ELRE--QKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQ 457
Query: 882 RLAALEAELKDSGEKPGKGASRPEDLQLIGRLQTRLKEREDIIKQLTEERRF 933
L+ ++ E+ D +K + + LQ + + KE+E K T ER F
Sbjct: 458 ELSRVKQEVVDVMKKSSE--EQIAKLQKLHEKELARKEQELTKKLQTREREF 507
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 127 bits (320), Expect = 4e-29
Identities = 213/975 (21%), Positives = 407/975 (41%), Gaps = 110/975 (11%)
Query: 41 KIAQLTKVIYALNTRQDEAEASMEALREAHQEELQNAVAET-------KARLLQEQGCAE 93
K+ L++ + AL + ++L+EAHQ+ L + E K EQ +
Sbjct: 978 KVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDD 1037
Query: 94 EEALLQRIQALESALELQKRLTEEALAESASCRLETKERELRVEAEHAERVLTLSREMLE 153
E L++ + L + LE KR E L S ++ + + ++E + ++ LS+ L+
Sbjct: 1038 LEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQ--LQ 1095
Query: 154 LKADYERRLQHLTSHEATPQGRLPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLSKD 213
K D E Q Q + K + E++E + LR + ++ D
Sbjct: 1096 AKIDDE-------------QVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSD 1142
Query: 214 YARKAEELQATYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLE 273
AR+ EE+ E + A ++ + + ++Q+ DL + +Q A A +RK +
Sbjct: 1143 LARELEEISERLEEASGATSAQIEMNKKREA-EFQKMRRDLEEA-TLQHEATAATLRKKQ 1200
Query: 274 GD-LEHRGRKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRM 332
D + G +I +L++ QKL++ +L +++ + L + + +D+
Sbjct: 1201 ADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQF 1260
Query: 333 MLQECRGTQQTDAM------KTELVSENKVLR---EENDLEAGNLHPQQDQSCLKECPCM 383
+ + QQT + K L ++N L EE + L + Q+ ++ +
Sbjct: 1261 SEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQL-TKSKQALTQQLEEL 1319
Query: 384 KGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEEKK-HLKDQLVKRLEDLV----KK 438
K + +TK + + +++ DL + +++ E+E K L+ L K ++ K
Sbjct: 1320 KRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKY 1379
Query: 439 HTVEIKSVRSSVEAERKKLQREVEAQ------------LEEVRKKSEKEIKQLEEEK--- 483
T I+ EA++K QR EA+ LE+ +++ + E++ L +
Sbjct: 1380 ETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERS 1439
Query: 484 ----AALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEESPQELGRQHCSILETQDPCLKLD 539
A L+ K +N + ++ + +++ A++ + L + + + +
Sbjct: 1440 HTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQL 1499
Query: 540 ETSPRG-----EEYQD--KLAAEEGTSSDEEERTKVLLK-EGSDPQPPLGSL---LKEKT 588
ET R EE D + AE G + E E+TK L++ E SD Q L + L+ +
Sbjct: 1500 ETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEE 1559
Query: 589 SKIQRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLE----------R 638
SKI R++ + K++L +V + + +EQ N + +AL+ + D E +
Sbjct: 1560 SKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLK 1619
Query: 639 EKLQRELQETTQQNHAMKAQLEASHQRALRMLE-KARHQELKATEE-RLKKESSHSLQIQ 696
+K++ +L E Q Q+ A Q+ LR ++ + + +L + R ++ L I
Sbjct: 1620 KKMEGDLNEMEIQLGHSNRQM-AETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIV 1678
Query: 697 HQTHRLELQALEEKARQELQEERERMQAQQALLLESLR-QELSEQQAACSGHQKDLEALQ 755
+ + L L+ LEE Q ER R ++Q LL S R Q L Q + +K LEA
Sbjct: 1679 ERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADI 1738
Query: 756 AELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGAAGQGSGEGCGLWEENAQLQ 815
A+ +A + K T+ A + L L+
Sbjct: 1739 AQCQAEVENSIQESRNAEEKAKKAITD-------AAMMAEELKKEQDTSAHLERMKKNLE 1791
Query: 816 DAVRRLRAEVEQHQQ--------EAQKLRDQRRFLEETQQAQRAREVETLRQEHR----- 862
V+ L+ +++ +Q + QKL ++ R LE ++ R E L+ H+
Sbjct: 1792 QTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKV 1851
Query: 863 KEMQAMVADFSSAQAQLQARLAALEAELKDSGEKPGKGASRPEDLQL--IGRLQTRLK-- 918
KEM + +LQ + L+A++K S ++ + A + QL R+Q L+
Sbjct: 1852 KEMTYQAEEDHKNILRLQDLVDKLQAKVK-SYKRQAEEAEEQANTQLSRCRRVQHELEEA 1910
Query: 919 -EREDIIKQLTEERR 932
ER DI + + R
Sbjct: 1911 AERADIAESQVNKLR 1925
Score = 124 bits (310), Expect = 6e-28
Identities = 180/782 (23%), Positives = 332/782 (42%), Gaps = 84/782 (10%)
Query: 197 LLEVQRLRVENQQLSKDYARKAEELQATYERENEAIR------------QAMQQSVSQAL 244
LL+ E + +D+ R EEL + R E Q QS ++ L
Sbjct: 843 LLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENL 902
Query: 245 WQWQEKESDLRKNFQVQESALQAQVRKLEGDLEHRGRKIS---DLKKYAQKLKERIQDLD 301
+E+ L K+ + E+ ++ +LE + E ++ +L+ LK I DL+
Sbjct: 903 MDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLE 962
Query: 302 VQLKEARQENSELKGTAKKLGEKLA--------VAKDRMMLQECRGTQQT-DAMKTE--- 349
+ L + +E + K L E++ + K++ LQE QQT D ++ E
Sbjct: 963 LTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAH--QQTLDDLQVEEDK 1020
Query: 350 ---LVSENKVLREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEASAETEYMKQQY 406
L+ N L ++ D G+L ++ E K D++ +E+ + E KQQ
Sbjct: 1021 VNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQI 1080
Query: 407 EEDLRKIKHQTEEEKKHLKDQLVKRLE--DLVKKHTVEIKSVRSSVEAERKKLQREVEAQ 464
EE L+K + + + + + D+ V L+ +K+ I+ + +EAE L+ ++E Q
Sbjct: 1081 EEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHT-LRAKIEKQ 1139
Query: 465 LEEVRKKSEKEIKQLEEEKAA------LNVKLQNSLLEVLR-LEEFIQQNK----TRPTG 513
++ ++ E+ ++LEE A +N K + ++ R LEE Q++ T
Sbjct: 1140 RSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKK 1199
Query: 514 AEESPQELGRQHCSILETQDPCLKLDETSPRGEEYQDKLAAEEGTSSDEE--ERTKVLLK 571
+S ELG Q ++ + K E S E D + E S + ERT ++
Sbjct: 1200 QADSVAELGEQIDNLQRVKQKLEK--EKSELKMEIDDMASNIEALSKSKSNIERTCRTVE 1257
Query: 572 EGSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQALK 631
+ S +K K + +L D QKA+LQ Q ++ +E+ S + L K
Sbjct: 1258 DQF-------SEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQ-LTKSK 1309
Query: 632 QLSDLEREKLQRELQETTQQNHAMKAQLEAS-HQRALRMLEKARHQELKATEER-LKKES 689
Q + E+L+R+++E T+ +AM L++S H L + QE KA +R L K +
Sbjct: 1310 QALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKAN 1369
Query: 690 SHSLQ--IQHQTHRL----ELQALEEKARQELQEERERMQA--QQALLLESLRQELSEQQ 741
S Q +++T + EL+ ++K Q LQE E + + LE +Q L Q
Sbjct: 1370 SEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRL---Q 1426
Query: 742 AACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGAAGQGS 801
+DLE L ++Q + D ++A ++ A +
Sbjct: 1427 GEVEDLMRDLERSHTACATLDKKQRNF-------DKVLAEWKQKLDESQAELEAAQKESR 1479
Query: 802 GEGCGLWE-ENA--QLQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRAREVETLR 858
L++ NA ++ D + LR E + Q+E L +Q E + Q A + + L
Sbjct: 1480 SLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQ--IAETGKNLQEAEKTKKLV 1537
Query: 859 QEHRKEMQAMVADFSSAQAQLQARLAALEAELKD-SGEKPGKGASRPEDLQLIGRLQTRL 917
++ + ++Q + + + ++++ ++ EL E K + E+++ + R R
Sbjct: 1538 EQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRA 1597
Query: 918 KE 919
E
Sbjct: 1598 AE 1599
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 125 bits (315), Expect = 2e-28
Identities = 206/886 (23%), Positives = 390/886 (44%), Gaps = 114/886 (12%)
Query: 92 AEEEALLQRIQALESALELQKRLTEEALAESASCRLETKERELRVEAE-HAERVLTLSRE 150
A +EAL ++ Q +E L +R E A A+ + E+EL + + H + VL L +
Sbjct: 352 ALQEALKEKQQHIEQLLA--ERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAK 409
Query: 151 MLELK-----ADYER-----RLQHLTSHEATPQGRLPQESPETKSEPGQGPEMQEVLLEV 200
M +L+ AD E+ +L+ Q R+ +ES TK + EV
Sbjct: 410 MDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESI-TKGD-------LEVATVS 461
Query: 201 QRLRVENQQLSKDYARKAEELQATYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQV 260
++ R+ +L KD A + +E+ A R E+ + A +S +L Q + S L++ +V
Sbjct: 462 EKSRI--MELEKDLALRVQEV-AELRRRLESNKPAGDVDMSLSLLQ---EISSLQEKLEV 515
Query: 261 QESALQAQVRKLEGDLEHRG-------RKISDLKKYAQKLKERIQDLDVQLKEARQENSE 313
+ Q ++ L+ EH G ++I L +KL + + L +L+ A +ENS+
Sbjct: 516 TRTDHQREITSLK---EHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSD 572
Query: 314 LKGTAKKLGEKLAVAKDRMMLQECR-----GTQQTDAMKTELVSENKVLREENDLEAGNL 368
+ K E A+A + ++E + G A EL ++ + +R + E NL
Sbjct: 573 VIALWKSKLET-AIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENL 631
Query: 369 HPQQDQ---SCLKECPCMKGGTDMQTK-KEASAETEYMKQQYEEDLRKIKHQTEEEKKHL 424
QQD + KE ++ K KE S E K ED ++ + K
Sbjct: 632 QNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQE 691
Query: 425 KDQLVKRLEDLVKK---HTVEIKSVRSSVEAERKKL---------QREVEAQLEEVRKK- 471
+ VK LE L K T I + S ++A +KL E +++++++R++
Sbjct: 692 AEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQL 751
Query: 472 --SEKEIKQLEEEKAALNVK-----------------LQNSLLEVLRLEEFIQQNKT--R 510
+EK+IK LE EK A + K LQ +L EV +++E +++ +
Sbjct: 752 EAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILK 811
Query: 511 PTGAEESPQELGRQHCSILETQDPCLKLDET----SPRGEEYQDKLAAEEGTSSDEEERT 566
AE S + + Q S+ ET + + +E S E+ ++ LA E +++ER
Sbjct: 812 EKFAEASEEAVSVQR-SMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDERE 870
Query: 567 KVLLKEGSDPQPPLGSLLK---EKTSKIQRLE----------EDWQSQKAKLQAQVSQMQ 613
+ L+K + + ++K + +S++ ++ E+ Q + K S +Q
Sbjct: 871 EQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQ 930
Query: 614 QALEQCTSNYREDLQALKQLSDLEREKLQR---ELQETTQQNHAMKAQLEASHQRALRML 670
+++E T + Q + + E+++L+R +L++ + +H +L+A ++RA
Sbjct: 931 KSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSET 990
Query: 671 EKARHQELKATEERLKKESSHSLQIQHQTHRLELQALEEKARQELQEERERMQAQQAL-L 729
K +H+E+ ++ ++ L+ + + LQ LEE R++ + + A+ A+ +
Sbjct: 991 -KTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEE-LRKQADKAKAAQTAEDAMQI 1048
Query: 730 LESLRQELSEQQAACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIATEERGGPG- 788
+E + +E +E A+ ++ LQ EL L + + ++ E +
Sbjct: 1049 MEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEF 1108
Query: 789 --QAGSPPGAAGQGSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQ 846
+ + AA Q S + L EEN +L + + R R EV H QKL ++R L
Sbjct: 1109 RKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSH----QKLEEERSVLNNQL 1164
Query: 847 QAQRAREVETLR--QEHRKEMQAMVADFSSAQAQLQARLAALEAEL 890
+ RE + ++ E + +Q ++ S+ + A L L E+
Sbjct: 1165 LEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEV 1210
Score = 88.2 bits (217), Expect = 4e-17
Identities = 137/682 (20%), Positives = 295/682 (43%), Gaps = 67/682 (9%)
Query: 57 DEAEASMEALREAHQEELQNAVAETKARLLQEQGCAEEEALLQRIQA-LESALELQKRLT 115
+ + ++ R AH +E++ +A+L++ E+E L+ I++ L+ A +
Sbjct: 629 ENLQNQQDSERAAHAKEME----ALRAKLMKV--IKEKENSLEAIRSKLDKAEDQHLVEM 682
Query: 116 EEALAESASCRLETKERELRVEAEHAERVLTLSREMLELKADYERRLQHLTSHEATPQGR 175
E+ L + ++ KE E+ ++A+ E+ + +LKA E+ L +A+ +G+
Sbjct: 683 EDTLNKLQEAEIKVKELEV-LQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGK 741
Query: 176 LPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYARKAEELQATYERENEAIRQA 235
+ + E E Q LE+++ ++ S + EL+ T +EN +
Sbjct: 742 SEMKKLRQQLEAA---EKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQ 798
Query: 236 MQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEHRGRKISDLKKYAQKLKE 295
+++++ + L +EK ++ + + ++Q V KL E SDL +KL+E
Sbjct: 799 VKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDL----EKLRE 854
Query: 296 RIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECRGTQQTDAMKTELVSENK 355
+ D++ + +E + +L +KL +A +M + Q M EL +
Sbjct: 855 NLADMEAKFREKDEREEQLIKAKEKLENDIA----EIMKMSGDNSSQLTKMNDELRLKE- 909
Query: 356 VLREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEASAETEYMKQQYEEDLRKIKH 415
R+ +L+ ++ S L+ K DM K E S + K + E+ + K
Sbjct: 910 --RDVEELQLKLTKANENASFLQ-----KSIEDMTVKAEQSQQEAAKKHEEEKKELERKL 962
Query: 416 QTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERKKLQREVEAQLEEVRKKSEKE 475
E+K + L+ ++ T E K+ + +K + E +L+ R+++
Sbjct: 963 SDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGL 1022
Query: 476 IKQLEE-EKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEESPQELGRQHCSILET-QD 533
+++LEE K A K + + +++ E + + KT + E ++ + + L+T ++
Sbjct: 1023 LQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKE 1082
Query: 534 PCLK-----------LDETSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLGS 582
LK L + + EE++ ++ + ++ + ++ L +E LG
Sbjct: 1083 NNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGR 1142
Query: 583 LLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQ 642
E TS Q+LEE+ ++ L Q+ +M++ RE K + D + EK
Sbjct: 1143 SRDEVTSH-QKLEEE----RSVLNNQLLEMKK---------RES----KFIKDADEEKAS 1184
Query: 643 RELQETTQQNHAMKAQLEASHQRALRMLEKARHQELKATEERLKKESSHSLQIQHQTHRL 702
LQ++ A+ + +A LEK R++ E +S HS+ ++ ++
Sbjct: 1185 --LQKSISITSALLTEKDAE-------LEKLRNEVTVLRGENASAKSLHSVVQTLESDKV 1235
Query: 703 ELQALEEKARQELQEERERMQA 724
+L+ + +L+E + ++ +
Sbjct: 1236 KLELKVKNLELQLKENKRQLSS 1257
Score = 86.7 bits (213), Expect = 1e-16
Identities = 185/898 (20%), Positives = 355/898 (39%), Gaps = 165/898 (18%)
Query: 68 EAHQEELQNAVAETKARLLQEQGCAEEEALLQRIQALESALELQKRLTEEALAESASCRL 127
+A ++ +A T A L + + ++ ++ S LTE + +
Sbjct: 290 KAKANAVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISG 349
Query: 128 ETKERE-LRVEAEHAERVLTLSREMLELKADYERRLQHLTSHEATPQ-GRLPQESPETKS 185
T +E L+ + +H E++L ER L+ +AT G + QE +
Sbjct: 350 TTALQEALKEKQQHIEQLLA------------ERDLERAEVAKATSHVGEIEQELALARD 397
Query: 186 EPGQGPEMQEVLLEVQRLRVENQQLSK--------DYARKAEELQATYERENEAIRQAMQ 237
Q E ++ R VE K + RK E+LQ E E+
Sbjct: 398 GHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEV 457
Query: 238 QSVSQALWQWQEKESDLRKNFQ-VQESALQAQVRKLEGDLEHRGRKISDLKKYAQKLKER 296
+VS+ + E E DL Q V E + + K GD++ + ++ +KL+
Sbjct: 458 ATVSEKS-RIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVT 516
Query: 297 IQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECRGTQQTDAMKTELVSENK- 355
D ++ ++ + T +K + L A +++ +++ +++K++L NK
Sbjct: 517 RTDHQREITSLKEHFGAREETHQKEIKALYTATEKL-------SKENESLKSKLEHANKE 569
Query: 356 ----VLREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEASAETEYMKQQYEEDLR 411
+ ++ LE QQ LK GT+ E + E M+ Y+ ++
Sbjct: 570 NSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIE 629
Query: 412 KIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERKKLQREVEAQLEEVRKK 471
+++Q + E+ H E++++R A+ K+ +E E LE +R K
Sbjct: 630 NLQNQQDSERA---------------AHAKEMEALR----AKLMKVIKEKENSLEAIRSK 670
Query: 472 SEK-EIKQLEEEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEESPQELGRQHCSILE 530
+K E + L E + LN KLQ + ++V LE + Q K E + + +
Sbjct: 671 LDKAEDQHLVEMEDTLN-KLQEAEIKVKELE--VLQAK-----CNEQTKVIDNFTSQLKA 722
Query: 531 TQDPCLKLDETSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLGSLLKEKTSK 590
T++ L LD + A+ EG S ++ R ++ E K K
Sbjct: 723 TEEKLLDLDAL---------RKASSEGKSEMKKLRQQLEAAE--------------KQIK 759
Query: 591 IQRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQRELQETTQ 650
+E++ +S KA + +++ Q E +N +E+L + Q+ +E L++ELQ +
Sbjct: 760 HLEIEKNAESSKA---SSITRELQGRELKLTNLQENLSEVSQV----KETLEKELQ-ILK 811
Query: 651 QNHAMKAQLEASHQRALRMLEKARHQELKATEERLKKESSHSLQIQHQTHRLELQALEEK 710
+ A ++ S QR+++ HQ K+E + L + R L +E K
Sbjct: 812 EKFAEASEEAVSVQRSMQETVNKLHQ---------KEEQFNMLSSDLEKLRENLADMEAK 862
Query: 711 ARQELQEERERMQAQQALLLESLRQELSEQQAACSGHQKDLEALQAELRALGRQQASSQC 770
R++ + E + ++A+ E L +++E + L + ELR R Q
Sbjct: 863 FREKDEREEQLIKAK-----EKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQL 917
Query: 771 PGDSKDHIIATEERGGPGQAGSPPGAAGQGSGEGCGLWEENAQ-LQDAVRRLRAEVEQHQ 829
+ ENA LQ ++ + + EQ Q
Sbjct: 918 KLTKAN---------------------------------ENASFLQKSIEDMTVKAEQSQ 944
Query: 830 QEAQKLRDQRRFLEETQQAQRAREVETLRQEHRKEMQAMVADFSSAQAQLQAR----LAA 885
QEA K ++ E+ + ++ ++E + + Q + A + A ++ + + L
Sbjct: 945 QEAAKKHEE----EKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQN 1000
Query: 886 LEAELKDSGEKPGKGASRPEDLQLIGRLQTRLKERE------------DIIKQLTEER 931
L+ L D+ +K KGA R E+ L+ L+ K+ + I++Q+T+E+
Sbjct: 1001 LQKTLLDTEDKL-KGA-REENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEK 1056
Score = 84.3 bits (207), Expect = 5e-16
Identities = 155/721 (21%), Positives = 296/721 (41%), Gaps = 131/721 (18%)
Query: 34 MHVKMCKKIAQLTKVIYALNTRQDEAEASMEALREAHQEELQNAVAETKARLLQEQGCAE 93
+ K+ K I + + A+ ++ D+AE E +LQ A + K + + C E
Sbjct: 649 LRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNE 708
Query: 94 EEALLQRIQALESALELQKRLTEEALAESASCRLETKERELRVEAEHAERVL-------- 145
+ ++ + A E +K L +AL + AS +++ ++LR + E AE+ +
Sbjct: 709 QTKVIDNFTSQLKATE-EKLLDLDALRK-ASSEGKSEMKKLRQQLEAAEKQIKHLEIEKN 766
Query: 146 -------TLSREML--ELKADYERRLQHLTSHEATPQGRLPQESPETKSEPGQGPE---- 192
+++RE+ ELK LQ S + + L +E K + + E
Sbjct: 767 AESSKASSITRELQGRELKLT---NLQENLSEVSQVKETLEKELQILKEKFAEASEEAVS 823
Query: 193 ----MQEVLLEVQRLRVENQQLSKDYARKAEEL---QATY----ERENEAIR--QAMQQS 239
MQE + ++ + + LS D + E L +A + ERE + I+ + ++
Sbjct: 824 VQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLEND 883
Query: 240 VSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEHRGRKISDLKKYAQKLKERIQD 299
+++ + + S L K + ++R E D+E K++ + A L++ I+D
Sbjct: 884 IAEIMKMSGDNSSQLTK--------MNDELRLKERDVEELQLKLTKANENASFLQKSIED 935
Query: 300 LDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECRGTQQTDAMKTELVSENKVLRE 359
+ V+ ++++QE ++ KK E+ ++ M Q+ A SE K E
Sbjct: 936 MTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHE 995
Query: 360 ENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEE 419
E NL K D + K + + E Q E+LRK Q ++
Sbjct: 996 E---ILQNL--------------QKTLLDTEDKLKGAREENSGLLQELEELRK---QADK 1035
Query: 420 EK-KHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERKKLQREVEAQLEEVRKKSEKEIKQ 478
K + ++ +E + K+ T + S+ + K+ +++ +L+ +++ + K +++
Sbjct: 1036 AKAAQTAEDAMQIMEQMTKEKTETLASLE-----DTKQTNAKLQNELDTLKENNLKNVEE 1090
Query: 479 LEEEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEESPQELGRQHCSILETQDPCLKL 538
L + K L V+ Q ++EEF ++ +T A + Q+L
Sbjct: 1091 LNKSKELLTVENQ-------KMEEFRKEIETLKQAAAQKSQQLSAL-------------- 1129
Query: 539 DETSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLGSLLKEKTSKIQRLEEDW 598
+E KLA E G S DE + L +E S L + L E + + +D
Sbjct: 1130 -------QEENVKLAEELGRSRDEVTSHQKLEEERS----VLNNQLLEMKKRESKFIKDA 1178
Query: 599 QSQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMK-- 656
+KA LQ +S TS AL D E EKL+ E+ +N + K
Sbjct: 1179 DEEKASLQKSIS--------ITS-------ALLTEKDAELEKLRNEVTVLRGENASAKSL 1223
Query: 657 -AQLEASHQRALRMLEKARHQELKATEERLKKESSHSLQIQHQTHRLELQALEEKARQEL 715
+ ++ +++ K ++ EL+ E + + SS + + QA E++ QE
Sbjct: 1224 HSVVQTLESDKVKLELKVKNLELQLKENKRQLSSS--------SGNTDTQADEDERAQES 1275
Query: 716 Q 716
Q
Sbjct: 1276 Q 1276
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 125 bits (314), Expect = 2e-28
Identities = 182/780 (23%), Positives = 350/780 (44%), Gaps = 103/780 (13%)
Query: 199 EVQRLRVENQQLSKDYARKAEELQATYERENEAIRQAMQQSVSQALWQWQEKESDLRKNF 258
EVQRLR N+ LS++ + A LQ +++ E +RQ ++ QA + ++ D +
Sbjct: 590 EVQRLRSANELLSREKSNLAHSLQVA-QQQAEELRQEREKL--QAAQEELRRQRDRLE-- 644
Query: 259 QVQESALQ--AQVRKLEGDLEHRGRKISDLKKYAQKLKERIQDLDVQLKEARQENSELKG 316
+ QE A+Q A+VR+ +LE R++ L+ L + + ++ L A + L+
Sbjct: 645 EEQEDAVQDGARVRR---ELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQA 701
Query: 317 TAKKLGEKLAVAKDRMMLQECRGTQQTDAMKTELVSENKVLREE-NDLEAGNLHPQQDQS 375
++ E L A+ G + + T+L +E L++ + L A N QD+
Sbjct: 702 EKAEVAEALTKAE--------AGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKL 753
Query: 376 CLKECPCM--KGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEEKKHLKDQL--VKR 431
L + + +Q ++ + + + ++ +E L +++ + E ++ L+ L ++
Sbjct: 754 DLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQ 813
Query: 432 LEDLVKKHTVEIKSVRSSVEAERKKLQREV---EAQLEEVRKKSEKEIKQLE-------- 480
++ +++ ++ RS ++ + +L R++ E +LE+ R++++++++ LE
Sbjct: 814 AQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEA 873
Query: 481 --EEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEESPQELGRQHCSI------LETQ 532
+E A L V+L + E L E + + E S E+ RQ + LE +
Sbjct: 874 LAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAE 933
Query: 533 DPCLKLDETSPRGEEY---QDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLGSLLKEKTS 589
L L + + GE Q +A +E S D+E + L++ + Q L
Sbjct: 934 GQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEE 993
Query: 590 KIQRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQRELQETT 649
+QRL+ + ++ +L+A+ +Q+Q L+ RE + L +L + E+E+L E+
Sbjct: 994 DLQRLQREKEAAWRELEAERAQLQSQLQ------REQEELLARL-EAEKEELSEEIAALQ 1046
Query: 650 QQNHAMKAQLEASHQRALRMLEKARHQELKATEERLKKESSHSLQIQHQTHRLELQALEE 709
Q+ E+ Q+AL + E E A E+L + HSL T LE++ +
Sbjct: 1047 QERDEGLLLAESEKQQALSLKE----SEKTALSEKL-MGTRHSL----ATISLEMERQKR 1097
Query: 710 KARQELQEERERMQAQQALLLESLRQELSEQQAACSGHQKDLEALQAELRALGRQQASS- 768
A+ +++R + A L LR ++++ A + H +++ LQ + R LG+Q+ S
Sbjct: 1098 DAQSRQEQDRSTVNA----LTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCL 1153
Query: 769 ----------QCPGDSKDHI----------IATEERGGPGQ---AGSPPGAAGQGSGEGC 805
+ D++D + + + G Q AG + G+G+ E
Sbjct: 1154 REAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKERE 1213
Query: 806 GLWEENAQLQDAVRRLRAE-------VEQHQQEAQKLRDQRRFL--EETQQAQRAREVET 856
L N +L+ AV++ +E E +Q+ L + R + E + +EVE
Sbjct: 1214 ALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVER 1273
Query: 857 LRQEHRKEMQAM---VADFSSAQAQLQARLAALEAELKDSGEKPGKGASRPEDLQLIGRL 913
R E R+E+Q + + S +L LA L+ L GE+ K SR E L L RL
Sbjct: 1274 SRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLA-LGERAEK-ESRRETLGLRQRL 1331
Score = 109 bits (272), Expect = 2e-23
Identities = 212/943 (22%), Positives = 377/943 (39%), Gaps = 127/943 (13%)
Query: 49 IYALNTRQDEAEASMEALREAHQEELQNAVAETKARLLQEQGCAEE-EALLQRIQALESA 107
+ AL + + A E AH +E++ + + Q C E E L +++ LE A
Sbjct: 1110 VNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDA 1169
Query: 108 --------LELQKRLTEE----------------ALAESASCR--LETKERELR--VEAE 139
LE Q++L E +L E A R L ELR V+
Sbjct: 1170 RDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKA 1229
Query: 140 HAERV-LTLSREMLELKADYERRLQHLTSHEATPQGRLPQESPETKSEPGQGPEMQEVLL 198
+ER+ L L+ E E K + EA QE ++ E + E+QE+
Sbjct: 1230 ESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARR--ELQELRR 1287
Query: 199 EVQRLRVENQQLSKDYARKAEELQATYERENEAIRQAMQQSVSQALWQWQEKESDLRKNF 258
+++ L EN +L ++ A L E E+ R+ + + Q L + + +R+
Sbjct: 1288 QMKMLDSENTRLGRELAELQGRLALGERAEKESRRETL--GLRQRLLKGEASLEVMRQEL 1345
Query: 259 QVQESALQAQVRKLEGDLEHRGRKISDLKKYAQKLKERIQD----LDVQLKEARQENSEL 314
QV + LQ Q EG+ R R++ + A+ +++ D L+++L+ AR E +EL
Sbjct: 1346 QVAQRKLQEQ----EGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAEL 1401
Query: 315 -------KGTAKKLGEKLAVAKDRMMLQECR--------------GTQQTDAMKTELVSE 353
+G A+ L +LA + + E + G + A + S
Sbjct: 1402 GLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSP 1461
Query: 354 NKVLREENDLEAGNLHPQQDQSCLKECPCMKGGT-----DMQTKKEASAETEYMKQ---- 404
+ E E N + S + P T D+ + A E++++
Sbjct: 1462 ARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSA 1521
Query: 405 QYEEDLRKIKHQTEEEKKHL------KDQLVKRLEDLVKKHTVEIKSVRSSVEAERKKLQ 458
Q E D +++ QT + L +D R L +K E + R SV+ +Q
Sbjct: 1522 QRERD--ELRTQTSALNRQLAEMEAERDSATSRARQL-QKAVAESEEARRSVDGRLSGVQ 1578
Query: 459 REVEAQLEEVRKKSEKEIKQLEEEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEESP 518
E+ Q E VR+ SE+E + ++ A L LQ + E+ +E I + K T E
Sbjct: 1579 AELALQEESVRR-SERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDK 1637
Query: 519 QELGRQHCSILETQDPCLKLDETSPRGEEYQDKLAAEEGTSSDE--EERTKVLLKEGSDP 576
+ L ++ E++ L+L S GE + +L + + + ++R L ++ +D
Sbjct: 1638 RRL-KEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADS 1696
Query: 577 QPPLGSL---LKEKTSKIQRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQALKQL 633
+ G+L ++ + ++EE + + K++ + Q+ S ++L K L
Sbjct: 1697 EVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKAL 1756
Query: 634 SDLE--REKLQRELQETTQQNHAMKAQLEASHQRALRMLEKARHQELKATEERLKKESSH 691
+ E R+ LQ L Q + Q + ++ + + EL+ E + +
Sbjct: 1757 TACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLR 1816
Query: 692 SLQIQHQTHRLELQALEEKARQELQEERERMQAQQALLLESLRQ---ELSEQQAACSGHQ 748
+ Q Q E +A Q+LQ+ER +Q + L +L Q E E + + +
Sbjct: 1817 EVLRQRQ----EGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLE 1872
Query: 749 KDLEALQAELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGAAGQGSGEGCGLW 808
KD AL+ L + R++ S +D + + E+G + + G
Sbjct: 1873 KDRVALRRTLDKVEREKLRSH-----EDTVRLSAEKGRLDRTLT-------------GAE 1914
Query: 809 EENAQLQDAVRRLRAEV---EQHQQEAQKLRD-QRRFLEETQ--------QAQRAREVET 856
E A+ Q +++L A+V EQ AQ D Q++ LE Q QAQ R +E
Sbjct: 1915 LELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEA 1974
Query: 857 LRQEHRKEMQAMVADFSSAQAQLQARLAALEAELKDSGEKPGK 899
+ HR+ ++ + S+ + QLQ L A P K
Sbjct: 1975 RERAHRQRVRGLEEQVSTLKGQLQQELRRSSAPFSPPSGPPEK 2017
Score = 101 bits (251), Expect = 4e-21
Identities = 219/945 (23%), Positives = 376/945 (39%), Gaps = 122/945 (12%)
Query: 45 LTKVIYALNTRQDEAEASMEALREAHQEELQNAVAETKARLLQEQGCAEEEALLQRIQAL 104
L + I N Q E+ + A A LQ + +LLQ++ + E LL + +A
Sbjct: 50 LIREIVTRNLSQPESPVLLPATEMASLLSLQE-----ENQLLQQE-LSRVEDLLAQSRAE 103
Query: 105 ESALELQKRLTEEALAESASCRLETKERELRVEAEHAERVLTLSREMLELKADYERRLQH 164
L ++ E L ++ RLE E E + + + L R++ E +A Y R+LQ
Sbjct: 104 RDELAIKYNAVSERLEQAL--RLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQA 161
Query: 165 LTSHEATP-------QGRLPQESPETKSEPGQGPEMQEVLLEVQRLR--VENQQLSKDYA 215
+ QG++ Q SE Q + LE QRLR +Q L
Sbjct: 162 YQEGQQRQAQLVQRLQGKILQYKKRC-SELEQQLLERSGELEQQRLRDTEHSQDLESALI 220
Query: 216 RKAEELQ--ATYERENEAIRQAMQQ--SVSQALWQWQEKESDLRKNFQVQESALQAQVRK 271
R EE Q A+ + N +R+ + Q S +QAL D+RK + +
Sbjct: 221 RLEEEQQRSASLAQVNAMLREQLDQAGSANQAL------SEDIRK--------VTNDWTR 266
Query: 272 LEGDLEHR----GRKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAV 327
+LEHR R+ Y R+ L Q+ R+ SE+K +
Sbjct: 267 CRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVK-----------M 315
Query: 328 AKDRMMLQECRGTQQTDAMKTELVSENKVLREEN-DLEAG-NLHPQQDQSCLKECPCMKG 385
+R +LQ + EL ++ ++E L G L + ++ L++ ++
Sbjct: 316 FTERDLLQ----------LGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQA 365
Query: 386 GTDMQTKKEASAETEYMKQQYEEDLRK--IKHQTEE--------EKKHL-KDQLVKRL-E 433
+ Q + + E + +QQ + DL K + + E EK++L KDQ+ K L E
Sbjct: 366 QLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTE 425
Query: 434 DLVKKHTVEIKSVRSSVEAERKKLQREVEAQLEEVRKKSEKEIKQLEEEKAALNVKLQNS 493
L ++ ++ + + + LQ+ + + V SE ++ E+ A N
Sbjct: 426 KLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTA---DASNG 482
Query: 494 LLEVLRLEEFIQQNKTRPTGAEESPQELGRQHCSILET--------QDPCLKLDETSPRG 545
L L + + G SP+ CS T L++ + R
Sbjct: 483 SLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRY 542
Query: 546 EEYQDKLAAEEGTSSDEEERTKVL------LKEGSDPQPPLGSLLKEKTSKIQRLEEDWQ 599
E QD L SD E + L L++ +D + + +++ E
Sbjct: 543 EASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLS 602
Query: 600 SQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQRELQETTQQNHAMKAQL 659
+K+ L + QQ E+ RE LQA ++ +R++L+ E ++ Q ++ +L
Sbjct: 603 REKSNLAHSLQVAQQQAEELRQE-REKLQAAQEELRRQRDRLEEEQEDAVQDGARVRREL 661
Query: 660 EASHQRALRMLEKARH---QELKATEERLKKESSHSLQIQHQTHRL-ELQALEEKARQEL 715
E SH R L LE R +EL E L + + +Q + + E E R EL
Sbjct: 662 ERSH-RQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVEL 720
Query: 716 QEERERMQAQQALLLESLRQELSEQQAACSGHQKDLEALQAELR-----ALGRQQASSQC 770
+ +++A++A L +SL +LS + + + DL L A+L GRQ+ + Q
Sbjct: 721 ELSMTKLRAEEASLQDSL-SKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQE 779
Query: 771 PGDSKDHIIATEE---------RGGPGQAGSPPGAAGQGSGEGCGLWEENAQLQDAVRRL 821
+++ EE +G G A + L E +QLQ+ + +L
Sbjct: 780 ATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQL 839
Query: 822 RAEVEQHQQE-AQKLRDQRRFLEETQQAQRAREVETLRQEHRKEMQAMVA------DFSS 874
++ +QE Q R+ +R +E ++A ARE E L +EH +VA S
Sbjct: 840 SRQLSGREQELEQARREAQRQVEALERA--AREKEALAKEHAGLAVQLVAAEREGRTLSE 897
Query: 875 AQAQLQARLAALEAELKDSGEKPGKGASRPEDLQLIGRLQTRLKE 919
+L+ ALE L + + + +R E L+ G+ KE
Sbjct: 898 EATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKE 942
Score = 96.7 bits (239), Expect = 1e-19
Identities = 202/906 (22%), Positives = 371/906 (40%), Gaps = 129/906 (14%)
Query: 56 QDEAEASMEALREAHQEELQNAVAETKARLL---QEQGCAEEEALLQRIQALESALELQK 112
Q+ E + LR + +LQ +A+ +L QE A EA Q ++ALE A ++
Sbjct: 815 QEALEQQLPTLRH-ERSQLQEQLAQLSRQLSGREQELEQARREAQRQ-VEALERAAREKE 872
Query: 113 RLTEEALAESASCRLETKERELRVEAEHAERVLTLSREMLELKA-DYERRLQHLTSH--- 168
L +E + +L ERE R +E A R L L +E LE + +R+L L +
Sbjct: 873 ALAKEHAG--LAVQLVAAEREGRTLSEEATR-LRLEKEALEGSLFEVQRQLAQLEARREQ 929
Query: 169 -EATPQGRLPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYARKAEELQATYER 227
EA Q L + T G Q+++ ++ ++ + +++ + E QA+
Sbjct: 930 LEAEGQALLLAKETLTGELAGL---RQQIIATQEKASLDKELMAQKLVQAEREAQASLRE 986
Query: 228 ENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEHRGRKISDLK 287
+ A + +Q+ + W+E E+ + + LQ+Q+++ + +L ++ L+
Sbjct: 987 QRAAHEEDLQRLQREKEAAWRELEA--------ERAQLQSQLQREQEEL------LARLE 1032
Query: 288 KYAQKLKERIQDLDVQLKEA--RQENSELKGTAKKLGEKLAVAKDRMMLQECRGTQQTDA 345
++L E I L + E E+ + + + K EK A+++ L R + T +
Sbjct: 1033 AEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSE---KLMGTRHSLATIS 1089
Query: 346 MKTELVSENKVLREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEASAETEYMKQQ 405
++ E + R+E D N + + D++ ++E +A
Sbjct: 1090 LEMERQKRDAQSRQEQDRSTVNALTSELR-------------DLRAQREEAAAA------ 1130
Query: 406 YEEDLRKIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERKKLQREVEAQL 465
+ +++R+++ Q + K +D ++ E E+++ +E R L+RE+ L
Sbjct: 1131 HAQEVRRLQEQARDLGKQ-RDSCLREAE--------ELRTQLRLLEDARDGLRREL---L 1178
Query: 466 EEVRK-KSEKEIKQLEEEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEESPQELGRQ 524
E RK + +E ++++ ++A +L+ SL E + E +++ S +EL R
Sbjct: 1179 EAQRKLRESQEGREVQRQEAG---ELRRSLGEGAKEREALRR----------SNEEL-RS 1224
Query: 525 HCSILETQDPCLKLDETSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLGSLL 584
E++ LKL E+ + KLA EE RT V G
Sbjct: 1225 AVKKAESERISLKL-----ANEDKEQKLALL------EEARTAV------------GKEA 1261
Query: 585 KEKTSKIQRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYRE--DLQALKQLSDLEREKLQ 642
E + +Q +E + +LQ QM+ + T RE +LQ L + ++ +
Sbjct: 1262 GELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESR 1321
Query: 643 RELQETTQQNHAMKAQLEASHQRALRMLEKARHQ--ELKATEERL--KKESSHSLQIQHQ 698
RE Q+ +A LE Q K + Q E + E RL E + + Q
Sbjct: 1322 RETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQL 1381
Query: 699 THRLELQALEEKARQELQEERERMQAQQALLLESLRQELSEQQAACSGHQKDLEALQAEL 758
H L+ E AR E E R+ A + + L EL+ + + L L++ L
Sbjct: 1382 DHARGLELKLEAARAEAAELGLRLSAAEG-RAQGLEAELARVEVQRRAAEAQLGGLRSAL 1440
Query: 759 R---ALGRQQASSQCPGDSKDHIIATEERGGPG---------QAGSPPGAAGQGSGEGCG 806
R LGR + + P A E G G GS P + G +
Sbjct: 1441 RRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASP 1500
Query: 807 LWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFL-EETQQAQRAREVETLRQEHRKEM 865
+ A ++ A+R E+ Q+E +LR Q L + + + R+ T R +++
Sbjct: 1501 DLDPEA-VRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSR---ARQL 1556
Query: 866 QAMVADFSSAQAQLQARLAALEAELKDSGEKPGKG-ASRPEDLQLIGRLQTRLKEREDII 924
Q VA+ A+ + RL+ ++AEL E + R L + L+ L+ E +
Sbjct: 1557 QKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESEL 1616
Query: 925 KQLTEE 930
+ E+
Sbjct: 1617 RASQEK 1622
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 125 bits (313), Expect = 3e-28
Identities = 188/896 (20%), Positives = 393/896 (43%), Gaps = 118/896 (13%)
Query: 54 TRQDEAEASMEALREAHQEELQNAVAETKARLLQEQGCAEEEALLQRIQALESALELQKR 113
TRQ+E +A ++ELQ +TK R Q AE E L+ ++ S L +K
Sbjct: 848 TRQEEE-------MQAKEDELQ----KTKER----QQKAENE--LKELEQKHSQLTEEKN 890
Query: 114 LTEEALAESASCRLETKERELRVEAEHAERVLTLSREMLELKADYERRLQHLTSHEATPQ 173
L +E L E +E +R+ A+ +E+ E+ + E RL+ +
Sbjct: 891 LLQEQLQAETELYAEAEEMRVRLAAK--------KQELEEILHEMEARLEE-------EE 935
Query: 174 GRLPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYA----RKAEELQATYEREN 229
R Q E K Q +++E L E + R + QL K A +K E+ + +N
Sbjct: 936 DRGQQLQAERKKMAQQMLDLEEQLEEEEAAR-QKLQLEKVTAEAKIKKLEDEILVMDDQN 994
Query: 230 EAI---RQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEHRGRKISDL 286
+ R+ +++ +S E+E + KN ++ ++ + +LE L+ + +L
Sbjct: 995 NKLSKERKLLEERISDLTTNLAEEE-EKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL 1053
Query: 287 KKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECRGTQQTDAM 346
+K +KL+ D Q+ + + + +ELK K E+L A R+ + Q+ +A+
Sbjct: 1054 EKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL---DDEIAQKNNAL 1110
Query: 347 K--TELVSENKVLREENDLE--AGNLHPQQDQSCLKECPCMKGGTDMQTKKEASAETEYM 402
K EL L+E+ D E A N +Q + +E +K T+++ +++A + +
Sbjct: 1111 KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALK--TELEDTLDSTATQQEL 1168
Query: 403 KQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERKKLQREVE 462
+ + E+++ +K +EE + + Q ++++ +KH ++ + +E ++ +
Sbjct: 1169 RAKREQEVTVLKKALDEETRSHEAQ----VQEMRQKHAQAVEELTEQLEQFKR-----AK 1219
Query: 463 AQLEEVRKKSEKEIKQLEEEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEESPQELG 522
A L++ ++ EKE L E L Q + +LE +Q+ +++ + E + EL
Sbjct: 1220 ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELN 1279
Query: 523 -RQHCSILETQDPCLKLDETSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLG 581
+ H E + L+E + + +A+ D +E + ++ + L
Sbjct: 1280 DKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLR 1339
Query: 582 SLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKL 641
L +E+ S +L+E+ ++ K L+ +S + L ++ ++ L + +++
Sbjct: 1340 QLEEERNSLQDQLDEEMEA-KQNLERHISTLNIQLSDSKKKLQDFASTVEALEE-GKKRF 1397
Query: 642 QRELQETTQQNHAMKAQLEASHQRALRMLEKARHQELKATEERLKKESSHSLQIQHQTHR 701
Q+E++ TQQ + A + +L+ T+ RL++E L + R
Sbjct: 1398 QKEIENLTQQYEE----------------KAAAYDKLEKTKNRLQQELD-DLVVDLDNQR 1440
Query: 702 LELQALEEKARQ--ELQEERERMQAQQALLLESLRQELSEQQAACSGHQKDL-EALQAEL 758
+ LE+K R+ +L E + + ++ A + E E++ + L EAL+A+
Sbjct: 1441 QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKE 1500
Query: 759 RALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGAAGQGSGEGCGLWEENAQLQDAV 818
++ + + +D + + ++ G + +L+ +
Sbjct: 1501 EL---ERTNKMLKAEMEDLVSSKDDVG-----------------------KNVHELEKSK 1534
Query: 819 RRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRAREV--ETLRQEHRKEMQAMVADFSSAQ 876
R L ++E+ + + ++L D+ L+ T+ A+ EV + L+ + +++QA +
Sbjct: 1535 RALETQMEEMKTQLEELEDE---LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKR 1591
Query: 877 AQLQARLAALEAELKDSGEKPGKGASRPEDLQ-----LIGRLQTRLKEREDIIKQL 927
QLQ +L E EL+D ++ A+ + L+ L + + +K RE+ IKQL
Sbjct: 1592 RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL 1647
Score = 117 bits (292), Expect = 7e-26
Identities = 199/906 (21%), Positives = 373/906 (41%), Gaps = 130/906 (14%)
Query: 33 QMHVKMCKKIAQLTKVIYALNTRQDEAEASMEALRE--AHQEELQNAV---------AET 81
++ +++ KK +L + L+ + +++ +RE H +LQ + AE
Sbjct: 1080 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1139
Query: 82 KARLLQEQGCAEEEALLQRIQALESALELQKRLTEEALAESASCRLETKERELRVEA--- 138
+ R L E+ A + L + + + EL+ + +E + ET+ E +V+
Sbjct: 1140 QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1199
Query: 139 EHAERVLTLSREMLELK---ADYERRLQHLTSHEATPQGRL------PQESPETKSE-PG 188
+HA+ V L+ ++ + K A+ ++ Q L A G L QE K +
Sbjct: 1200 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA 1259
Query: 189 QGPEMQEVLLEVQRLRVENQ-------------------------QLSKDYARKAEELQA 223
Q E+Q + +R R E +L+KD A + +LQ
Sbjct: 1260 QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1319
Query: 224 TYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEHRGRKI 283
T E E RQ + +VS L Q +E+ + L+ + A Q LE + ++
Sbjct: 1320 TQELLQEETRQKL--NVSTKLRQLEEERNSLQDQLDEEMEAKQ----NLERHISTLNIQL 1373
Query: 284 SDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECRGTQQT 343
SD KK Q ++ L+ K ++E L + E+ A A D++ + R Q+
Sbjct: 1374 SDSKKKLQDFASTVEALEEGKKRFQKEIENLT----QQYEEKAAAYDKLEKTKNRLQQEL 1429
Query: 344 DAMKTELVSENKVLREENDLEAGNLHPQQ---DQSCLKECPCMKGGTDMQTKKEASAETE 400
D + +L ++ +++ NL +Q DQ +E D + + EA A +
Sbjct: 1430 DDLVVDLDNQRQLV--------SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1481
Query: 401 YMKQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERKKLQRE 460
K + + +EE + L +EDLV K+V E +K +R
Sbjct: 1482 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH-----ELEKSKRA 1536
Query: 461 VEAQLEEVRKKSEK---EIKQLEEEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEES 517
+E Q+EE++ + E+ E++ E+ K L V +Q +F + + R EE
Sbjct: 1537 LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ------ALKGQFERDLQARDEQNEEK 1590
Query: 518 PQELGRQHCSILETQDPCLKLDETSPRGEEYQDKLAAE-----EGTSSDEEERTKVLLKE 572
++L RQ L ET E Q LAA EG D E + +K
Sbjct: 1591 RRQLQRQ-----------LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKG 1639
Query: 573 GSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQQ---ALEQCTSNYREDLQA 629
+ L L + + QR ED ++ + ++ A + ++ +LE +EDL A
Sbjct: 1640 REEAIKQLRKL-QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1698
Query: 630 LKQL---SDLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLEKARHQE--LKATEER 684
++ +DLE+E+L EL + +A++ + R ++ E+ ++ ++A +R
Sbjct: 1699 AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDR 1758
Query: 685 LKKESSHSLQIQHQ--THRLELQALEEKARQELQEERERMQAQQALLLESLRQELSEQQA 742
++K + + Q+ ++ T R Q E ARQ+L+ + + ++++ + +++ + A
Sbjct: 1759 VRKATQQAEQLSNELATERSTAQK-NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIA 1817
Query: 743 ACSGHQKDLEALQAELRALGRQQASS---QCPGDSKDHIIATEERGGPGQAGSPPGAAGQ 799
A LE Q E A +Q A+ Q K+ ++ E+ + G
Sbjct: 1818 ALEAKIAQLEE-QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKG- 1875
Query: 800 GSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRA--REVETL 857
NA+++ R+L E+ Q+ R +R L+E ++ A REV L
Sbjct: 1876 -----------NARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNAL 1924
Query: 858 RQEHRK 863
+ + R+
Sbjct: 1925 KSKLRR 1930
Score = 115 bits (287), Expect = 3e-25
Identities = 228/1040 (21%), Positives = 425/1040 (40%), Gaps = 186/1040 (17%)
Query: 33 QMHVKMCKKIAQLTKVIYALNTRQDEAE--------------ASMEALREAHQEE----- 73
+M V++ K +L ++++ + R +E E M L E +EE
Sbjct: 908 EMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQ 967
Query: 74 ---LQNAVAETKARLLQEQGCA----------EEEALLQRIQALESAL----ELQKRLTE 116
L+ AE K + L+++ E + L +RI L + L E K LT+
Sbjct: 968 KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTK 1027
Query: 117 -----EALAESASCRLETKERELRVEAEHAERVLT-----LSREMLELKADYERRLQHLT 166
E++ RL+ KE + R E E +R L ++ +L+A L
Sbjct: 1028 LKNKHESMISELEVRLK-KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLA 1086
Query: 167 SHEATPQGRLPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYARKAEELQATYE 226
E Q L + E + +++E+ + L+ E+ + KAE+ +
Sbjct: 1087 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ-EDLDSERAARNKAEKQKRDLG 1145
Query: 227 RENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEHRGRK---- 282
E EA++ ++ ++ Q QE + + V + AL + R E ++ +K
Sbjct: 1146 EELEALKTELEDTLDSTATQ-QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1204
Query: 283 ISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECR---- 338
+ +L + ++ K +LD + +EN++L G + LG+ + + E +
Sbjct: 1205 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1264
Query: 339 GTQQTDAMKTELVSENKVLREENDLEA--GNLHPQQDQSCLKECPCMKGGTDMQTKKEAS 396
++ +D + +KV + +N++E+ G L+ + ++ + +Q +E
Sbjct: 1265 QSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL 1324
Query: 397 AETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDLVKKHTVE--IKSVRSSVEAER 454
E K LR Q EEE+ L+DQL + +E K +E I ++ + +
Sbjct: 1325 QEETRQKLNVSTKLR----QLEEERNSLQDQLDEEME---AKQNLERHISTLNIQLSDSK 1377
Query: 455 KKLQ---REVEAQLEEVRKKSEKEIKQLE---EEKAALNVKLQNSLLEVLR-LEEFIQQN 507
KKLQ VEA LEE +K+ +KEI+ L EEKAA KL+ + + + L++ +
Sbjct: 1378 KKLQDFASTVEA-LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDL 1436
Query: 508 KTRPTGAEESPQELGRQHCSILETQDPCLKLDETSPRGE-EYQDK--------LAAEEGT 558
+ ++ + + E ++ K + R E E ++K A EE
Sbjct: 1437 DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL 1496
Query: 559 SSDEE-ERTKVLLK------------------EGSDPQPPLGSLLKEKTSKIQRLEEDWQ 599
+ EE ERT +LK E + L + ++E ++++ LE++ Q
Sbjct: 1497 EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1556
Query: 600 S-QKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQRELQE------TTQQN 652
+ + AKL+ +V+ QAL+ + DLQA + ++ +R +LQR+L E ++
Sbjct: 1557 ATEDAKLRLEVNM--QALK---GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1611
Query: 653 HAMKAQLEASHQRALRMLEKARHQELKATEERLKKESSHSLQIQHQTHRLELQAL----- 707
A+ A + + L+ LE +K EE +K+ LQ Q + + EL+
Sbjct: 1612 RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQ--LRKLQAQMKDFQRELEDARASRD 1669
Query: 708 ---------EEKARQ------ELQEE---RERMQAQQALLLESLRQELSEQ--------- 740
E+KA+ +LQE+ ER + Q L E L +EL+
Sbjct: 1670 EIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQD 1729
Query: 741 -----QAACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPG 795
+A + +++LE Q + A+ + + + + +ATE
Sbjct: 1730 EKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER-----------S 1778
Query: 796 AAGQGSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRAREVE 855
A + L +N +L+ + + V+ K + LE A+ A+ E
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVK------SKFKSTIAALE----AKIAQLEE 1828
Query: 856 TLRQEHRKEMQAMVADFSSAQAQLQARLAALEAELK---DSGEKPGKGASRPEDLQLIGR 912
+ QE R E QA +L+ L +E E K E+ KG +R + +
Sbjct: 1829 QVEQEAR-EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNAR------VKQ 1881
Query: 913 LQTRLKEREDIIKQLTEERR 932
L+ +L+E E+ +++ RR
Sbjct: 1882 LKRQLEEAEEESQRINANRR 1901
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 125 bits (313), Expect = 3e-28
Identities = 188/896 (20%), Positives = 393/896 (43%), Gaps = 118/896 (13%)
Query: 54 TRQDEAEASMEALREAHQEELQNAVAETKARLLQEQGCAEEEALLQRIQALESALELQKR 113
TRQ+E +A ++ELQ +TK R Q AE E L+ ++ S L +K
Sbjct: 855 TRQEEE-------MQAKEDELQ----KTKER----QQKAENE--LKELEQKHSQLTEEKN 897
Query: 114 LTEEALAESASCRLETKERELRVEAEHAERVLTLSREMLELKADYERRLQHLTSHEATPQ 173
L +E L E +E +R+ A+ +E+ E+ + E RL+ +
Sbjct: 898 LLQEQLQAETELYAEAEEMRVRLAAK--------KQELEEILHEMEARLEE-------EE 942
Query: 174 GRLPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYA----RKAEELQATYEREN 229
R Q E K Q +++E L E + R + QL K A +K E+ + +N
Sbjct: 943 DRGQQLQAERKKMAQQMLDLEEQLEEEEAAR-QKLQLEKVTAEAKIKKLEDEILVMDDQN 1001
Query: 230 EAI---RQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEHRGRKISDL 286
+ R+ +++ +S E+E + KN ++ ++ + +LE L+ + +L
Sbjct: 1002 NKLSKERKLLEERISDLTTNLAEEE-EKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL 1060
Query: 287 KKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECRGTQQTDAM 346
+K +KL+ D Q+ + + + +ELK K E+L A R+ + Q+ +A+
Sbjct: 1061 EKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL---DDEIAQKNNAL 1117
Query: 347 K--TELVSENKVLREENDLE--AGNLHPQQDQSCLKECPCMKGGTDMQTKKEASAETEYM 402
K EL L+E+ D E A N +Q + +E +K T+++ +++A + +
Sbjct: 1118 KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALK--TELEDTLDSTATQQEL 1175
Query: 403 KQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERKKLQREVE 462
+ + E+++ +K +EE + + Q ++++ +KH ++ + +E ++ +
Sbjct: 1176 RAKREQEVTVLKKALDEETRSHEAQ----VQEMRQKHAQAVEELTEQLEQFKR-----AK 1226
Query: 463 AQLEEVRKKSEKEIKQLEEEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEESPQELG 522
A L++ ++ EKE L E L Q + +LE +Q+ +++ + E + EL
Sbjct: 1227 ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELN 1286
Query: 523 -RQHCSILETQDPCLKLDETSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLG 581
+ H E + L+E + + +A+ D +E + ++ + L
Sbjct: 1287 DKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLR 1346
Query: 582 SLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKL 641
L +E+ S +L+E+ ++ K L+ +S + L ++ ++ L + +++
Sbjct: 1347 QLEEERNSLQDQLDEEMEA-KQNLERHISTLNIQLSDSKKKLQDFASTVEALEE-GKKRF 1404
Query: 642 QRELQETTQQNHAMKAQLEASHQRALRMLEKARHQELKATEERLKKESSHSLQIQHQTHR 701
Q+E++ TQQ + A + +L+ T+ RL++E L + R
Sbjct: 1405 QKEIENLTQQYEE----------------KAAAYDKLEKTKNRLQQELD-DLVVDLDNQR 1447
Query: 702 LELQALEEKARQ--ELQEERERMQAQQALLLESLRQELSEQQAACSGHQKDL-EALQAEL 758
+ LE+K R+ +L E + + ++ A + E E++ + L EAL+A+
Sbjct: 1448 QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKE 1507
Query: 759 RALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGAAGQGSGEGCGLWEENAQLQDAV 818
++ + + +D + + ++ G + +L+ +
Sbjct: 1508 EL---ERTNKMLKAEMEDLVSSKDDVG-----------------------KNVHELEKSK 1541
Query: 819 RRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRAREV--ETLRQEHRKEMQAMVADFSSAQ 876
R L ++E+ + + ++L D+ L+ T+ A+ EV + L+ + +++QA +
Sbjct: 1542 RALETQMEEMKTQLEELEDE---LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKR 1598
Query: 877 AQLQARLAALEAELKDSGEKPGKGASRPEDLQ-----LIGRLQTRLKEREDIIKQL 927
QLQ +L E EL+D ++ A+ + L+ L + + +K RE+ IKQL
Sbjct: 1599 RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL 1654
Score = 117 bits (292), Expect = 7e-26
Identities = 199/906 (21%), Positives = 373/906 (41%), Gaps = 130/906 (14%)
Query: 33 QMHVKMCKKIAQLTKVIYALNTRQDEAEASMEALRE--AHQEELQNAV---------AET 81
++ +++ KK +L + L+ + +++ +RE H +LQ + AE
Sbjct: 1087 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1146
Query: 82 KARLLQEQGCAEEEALLQRIQALESALELQKRLTEEALAESASCRLETKERELRVEA--- 138
+ R L E+ A + L + + + EL+ + +E + ET+ E +V+
Sbjct: 1147 QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1206
Query: 139 EHAERVLTLSREMLELK---ADYERRLQHLTSHEATPQGRL------PQESPETKSE-PG 188
+HA+ V L+ ++ + K A+ ++ Q L A G L QE K +
Sbjct: 1207 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA 1266
Query: 189 QGPEMQEVLLEVQRLRVENQ-------------------------QLSKDYARKAEELQA 223
Q E+Q + +R R E +L+KD A + +LQ
Sbjct: 1267 QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1326
Query: 224 TYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEHRGRKI 283
T E E RQ + +VS L Q +E+ + L+ + A Q LE + ++
Sbjct: 1327 TQELLQEETRQKL--NVSTKLRQLEEERNSLQDQLDEEMEAKQ----NLERHISTLNIQL 1380
Query: 284 SDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECRGTQQT 343
SD KK Q ++ L+ K ++E L + E+ A A D++ + R Q+
Sbjct: 1381 SDSKKKLQDFASTVEALEEGKKRFQKEIENLT----QQYEEKAAAYDKLEKTKNRLQQEL 1436
Query: 344 DAMKTELVSENKVLREENDLEAGNLHPQQ---DQSCLKECPCMKGGTDMQTKKEASAETE 400
D + +L ++ +++ NL +Q DQ +E D + + EA A +
Sbjct: 1437 DDLVVDLDNQRQLV--------SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1488
Query: 401 YMKQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERKKLQRE 460
K + + +EE + L +EDLV K+V E +K +R
Sbjct: 1489 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH-----ELEKSKRA 1543
Query: 461 VEAQLEEVRKKSEK---EIKQLEEEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEES 517
+E Q+EE++ + E+ E++ E+ K L V +Q +F + + R EE
Sbjct: 1544 LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ------ALKGQFERDLQARDEQNEEK 1597
Query: 518 PQELGRQHCSILETQDPCLKLDETSPRGEEYQDKLAAE-----EGTSSDEEERTKVLLKE 572
++L RQ L ET E Q LAA EG D E + +K
Sbjct: 1598 RRQLQRQ-----------LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKG 1646
Query: 573 GSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQQ---ALEQCTSNYREDLQA 629
+ L L + + QR ED ++ + ++ A + ++ +LE +EDL A
Sbjct: 1647 REEAIKQLRKL-QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1705
Query: 630 LKQL---SDLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLEKARHQE--LKATEER 684
++ +DLE+E+L EL + +A++ + R ++ E+ ++ ++A +R
Sbjct: 1706 AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDR 1765
Query: 685 LKKESSHSLQIQHQ--THRLELQALEEKARQELQEERERMQAQQALLLESLRQELSEQQA 742
++K + + Q+ ++ T R Q E ARQ+L+ + + ++++ + +++ + A
Sbjct: 1766 VRKATQQAEQLSNELATERSTAQK-NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIA 1824
Query: 743 ACSGHQKDLEALQAELRALGRQQASS---QCPGDSKDHIIATEERGGPGQAGSPPGAAGQ 799
A LE Q E A +Q A+ Q K+ ++ E+ + G
Sbjct: 1825 ALEAKIAQLEE-QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKG- 1882
Query: 800 GSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRA--REVETL 857
NA+++ R+L E+ Q+ R +R L+E ++ A REV L
Sbjct: 1883 -----------NARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNAL 1931
Query: 858 RQEHRK 863
+ + R+
Sbjct: 1932 KSKLRR 1937
Score = 115 bits (287), Expect = 3e-25
Identities = 228/1040 (21%), Positives = 425/1040 (40%), Gaps = 186/1040 (17%)
Query: 33 QMHVKMCKKIAQLTKVIYALNTRQDEAE--------------ASMEALREAHQEE----- 73
+M V++ K +L ++++ + R +E E M L E +EE
Sbjct: 915 EMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQ 974
Query: 74 ---LQNAVAETKARLLQEQGCA----------EEEALLQRIQALESAL----ELQKRLTE 116
L+ AE K + L+++ E + L +RI L + L E K LT+
Sbjct: 975 KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTK 1034
Query: 117 -----EALAESASCRLETKERELRVEAEHAERVLT-----LSREMLELKADYERRLQHLT 166
E++ RL+ KE + R E E +R L ++ +L+A L
Sbjct: 1035 LKNKHESMISELEVRLK-KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLA 1093
Query: 167 SHEATPQGRLPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYARKAEELQATYE 226
E Q L + E + +++E+ + L+ E+ + KAE+ +
Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ-EDLDSERAARNKAEKQKRDLG 1152
Query: 227 RENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEHRGRK---- 282
E EA++ ++ ++ Q QE + + V + AL + R E ++ +K
Sbjct: 1153 EELEALKTELEDTLDSTATQ-QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1211
Query: 283 ISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECR---- 338
+ +L + ++ K +LD + +EN++L G + LG+ + + E +
Sbjct: 1212 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1271
Query: 339 GTQQTDAMKTELVSENKVLREENDLEA--GNLHPQQDQSCLKECPCMKGGTDMQTKKEAS 396
++ +D + +KV + +N++E+ G L+ + ++ + +Q +E
Sbjct: 1272 QSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL 1331
Query: 397 AETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDLVKKHTVE--IKSVRSSVEAER 454
E K LR Q EEE+ L+DQL + +E K +E I ++ + +
Sbjct: 1332 QEETRQKLNVSTKLR----QLEEERNSLQDQLDEEME---AKQNLERHISTLNIQLSDSK 1384
Query: 455 KKLQ---REVEAQLEEVRKKSEKEIKQLE---EEKAALNVKLQNSLLEVLR-LEEFIQQN 507
KKLQ VEA LEE +K+ +KEI+ L EEKAA KL+ + + + L++ +
Sbjct: 1385 KKLQDFASTVEA-LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDL 1443
Query: 508 KTRPTGAEESPQELGRQHCSILETQDPCLKLDETSPRGE-EYQDK--------LAAEEGT 558
+ ++ + + E ++ K + R E E ++K A EE
Sbjct: 1444 DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL 1503
Query: 559 SSDEE-ERTKVLLK------------------EGSDPQPPLGSLLKEKTSKIQRLEEDWQ 599
+ EE ERT +LK E + L + ++E ++++ LE++ Q
Sbjct: 1504 EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1563
Query: 600 S-QKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQRELQE------TTQQN 652
+ + AKL+ +V+ QAL+ + DLQA + ++ +R +LQR+L E ++
Sbjct: 1564 ATEDAKLRLEVNM--QALK---GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1618
Query: 653 HAMKAQLEASHQRALRMLEKARHQELKATEERLKKESSHSLQIQHQTHRLELQAL----- 707
A+ A + + L+ LE +K EE +K+ LQ Q + + EL+
Sbjct: 1619 RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQ--LRKLQAQMKDFQRELEDARASRD 1676
Query: 708 ---------EEKARQ------ELQEE---RERMQAQQALLLESLRQELSEQ--------- 740
E+KA+ +LQE+ ER + Q L E L +EL+
Sbjct: 1677 EIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQD 1736
Query: 741 -----QAACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPG 795
+A + +++LE Q + A+ + + + + +ATE
Sbjct: 1737 EKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER-----------S 1785
Query: 796 AAGQGSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRAREVE 855
A + L +N +L+ + + V+ K + LE A+ A+ E
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVK------SKFKSTIAALE----AKIAQLEE 1835
Query: 856 TLRQEHRKEMQAMVADFSSAQAQLQARLAALEAELK---DSGEKPGKGASRPEDLQLIGR 912
+ QE R E QA +L+ L +E E K E+ KG +R + +
Sbjct: 1836 QVEQEAR-EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNAR------VKQ 1888
Query: 913 LQTRLKEREDIIKQLTEERR 932
L+ +L+E E+ +++ RR
Sbjct: 1889 LKRQLEEAEEESQRINANRR 1908
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 125 bits (313), Expect = 3e-28
Identities = 188/896 (20%), Positives = 393/896 (43%), Gaps = 118/896 (13%)
Query: 54 TRQDEAEASMEALREAHQEELQNAVAETKARLLQEQGCAEEEALLQRIQALESALELQKR 113
TRQ+E +A ++ELQ +TK R Q AE E L+ ++ S L +K
Sbjct: 855 TRQEEE-------MQAKEDELQ----KTKER----QQKAENE--LKELEQKHSQLTEEKN 897
Query: 114 LTEEALAESASCRLETKERELRVEAEHAERVLTLSREMLELKADYERRLQHLTSHEATPQ 173
L +E L E +E +R+ A+ +E+ E+ + E RL+ +
Sbjct: 898 LLQEQLQAETELYAEAEEMRVRLAAK--------KQELEEILHEMEARLEE-------EE 942
Query: 174 GRLPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYA----RKAEELQATYEREN 229
R Q E K Q +++E L E + R + QL K A +K E+ + +N
Sbjct: 943 DRGQQLQAERKKMAQQMLDLEEQLEEEEAAR-QKLQLEKVTAEAKIKKLEDEILVMDDQN 1001
Query: 230 EAI---RQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEHRGRKISDL 286
+ R+ +++ +S E+E + KN ++ ++ + +LE L+ + +L
Sbjct: 1002 NKLSKERKLLEERISDLTTNLAEEE-EKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL 1060
Query: 287 KKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECRGTQQTDAM 346
+K +KL+ D Q+ + + + +ELK K E+L A R+ + Q+ +A+
Sbjct: 1061 EKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL---DDEIAQKNNAL 1117
Query: 347 K--TELVSENKVLREENDLE--AGNLHPQQDQSCLKECPCMKGGTDMQTKKEASAETEYM 402
K EL L+E+ D E A N +Q + +E +K T+++ +++A + +
Sbjct: 1118 KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALK--TELEDTLDSTATQQEL 1175
Query: 403 KQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERKKLQREVE 462
+ + E+++ +K +EE + + Q ++++ +KH ++ + +E ++ +
Sbjct: 1176 RAKREQEVTVLKKALDEETRSHEAQ----VQEMRQKHAQAVEELTEQLEQFKR-----AK 1226
Query: 463 AQLEEVRKKSEKEIKQLEEEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEESPQELG 522
A L++ ++ EKE L E L Q + +LE +Q+ +++ + E + EL
Sbjct: 1227 ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELN 1286
Query: 523 -RQHCSILETQDPCLKLDETSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLG 581
+ H E + L+E + + +A+ D +E + ++ + L
Sbjct: 1287 DKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLR 1346
Query: 582 SLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKL 641
L +E+ S +L+E+ ++ K L+ +S + L ++ ++ L + +++
Sbjct: 1347 QLEEERNSLQDQLDEEMEA-KQNLERHISTLNIQLSDSKKKLQDFASTVEALEE-GKKRF 1404
Query: 642 QRELQETTQQNHAMKAQLEASHQRALRMLEKARHQELKATEERLKKESSHSLQIQHQTHR 701
Q+E++ TQQ + A + +L+ T+ RL++E L + R
Sbjct: 1405 QKEIENLTQQYEE----------------KAAAYDKLEKTKNRLQQELD-DLVVDLDNQR 1447
Query: 702 LELQALEEKARQ--ELQEERERMQAQQALLLESLRQELSEQQAACSGHQKDL-EALQAEL 758
+ LE+K R+ +L E + + ++ A + E E++ + L EAL+A+
Sbjct: 1448 QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKE 1507
Query: 759 RALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGAAGQGSGEGCGLWEENAQLQDAV 818
++ + + +D + + ++ G + +L+ +
Sbjct: 1508 EL---ERTNKMLKAEMEDLVSSKDDVG-----------------------KNVHELEKSK 1541
Query: 819 RRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRAREV--ETLRQEHRKEMQAMVADFSSAQ 876
R L ++E+ + + ++L D+ L+ T+ A+ EV + L+ + +++QA +
Sbjct: 1542 RALETQMEEMKTQLEELEDE---LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKR 1598
Query: 877 AQLQARLAALEAELKDSGEKPGKGASRPEDLQ-----LIGRLQTRLKEREDIIKQL 927
QLQ +L E EL+D ++ A+ + L+ L + + +K RE+ IKQL
Sbjct: 1599 RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL 1654
Score = 116 bits (290), Expect = 1e-25
Identities = 199/905 (21%), Positives = 372/905 (41%), Gaps = 130/905 (14%)
Query: 33 QMHVKMCKKIAQLTKVIYALNTRQDEAEASMEALRE--AHQEELQNAV---------AET 81
++ +++ KK +L + L+ + +++ +RE H +LQ + AE
Sbjct: 1087 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1146
Query: 82 KARLLQEQGCAEEEALLQRIQALESALELQKRLTEEALAESASCRLETKERELRVEA--- 138
+ R L E+ A + L + + + EL+ + +E + ET+ E +V+
Sbjct: 1147 QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1206
Query: 139 EHAERVLTLSREMLELK---ADYERRLQHLTSHEATPQGRL------PQESPETKSE-PG 188
+HA+ V L+ ++ + K A+ ++ Q L A G L QE K +
Sbjct: 1207 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA 1266
Query: 189 QGPEMQEVLLEVQRLRVENQ-------------------------QLSKDYARKAEELQA 223
Q E+Q + +R R E +L+KD A + +LQ
Sbjct: 1267 QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1326
Query: 224 TYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEHRGRKI 283
T E E RQ + +VS L Q +E+ + L+ + A Q LE + ++
Sbjct: 1327 TQELLQEETRQKL--NVSTKLRQLEEERNSLQDQLDEEMEAKQ----NLERHISTLNIQL 1380
Query: 284 SDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECRGTQQT 343
SD KK Q ++ L+ K ++E L + E+ A A D++ + R Q+
Sbjct: 1381 SDSKKKLQDFASTVEALEEGKKRFQKEIENLT----QQYEEKAAAYDKLEKTKNRLQQEL 1436
Query: 344 DAMKTELVSENKVLREENDLEAGNLHPQQ---DQSCLKECPCMKGGTDMQTKKEASAETE 400
D + +L ++ +++ NL +Q DQ +E D + + EA A +
Sbjct: 1437 DDLVVDLDNQRQLV--------SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1488
Query: 401 YMKQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERKKLQRE 460
K + + +EE + L +EDLV K+V E +K +R
Sbjct: 1489 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH-----ELEKSKRA 1543
Query: 461 VEAQLEEVRKKSEK---EIKQLEEEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEES 517
+E Q+EE++ + E+ E++ E+ K L V +Q +F + + R EE
Sbjct: 1544 LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ------ALKGQFERDLQARDEQNEEK 1597
Query: 518 PQELGRQHCSILETQDPCLKLDETSPRGEEYQDKLAAE-----EGTSSDEEERTKVLLKE 572
++L RQ L ET E Q LAA EG D E + +K
Sbjct: 1598 RRQLQRQ-----------LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKG 1646
Query: 573 GSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQQ---ALEQCTSNYREDLQA 629
+ L L + + QR ED ++ + ++ A + ++ +LE +EDL A
Sbjct: 1647 REEAIKQLRKL-QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1705
Query: 630 LKQL---SDLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLEKARHQE--LKATEER 684
++ +DLE+E+L EL + +A++ + R ++ E+ ++ ++A +R
Sbjct: 1706 AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDR 1765
Query: 685 LKKESSHSLQIQHQ--THRLELQALEEKARQELQEERERMQAQQALLLESLRQELSEQQA 742
++K + + Q+ ++ T R Q E ARQ+L+ + + ++++ + +++ + A
Sbjct: 1766 VRKATQQAEQLSNELATERSTAQK-NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIA 1824
Query: 743 ACSGHQKDLEALQAELRALGRQQASS---QCPGDSKDHIIATEERGGPGQAGSPPGAAGQ 799
A LE Q E A +Q A+ Q K+ ++ E+ + G
Sbjct: 1825 ALEAKIAQLEE-QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKG- 1882
Query: 800 GSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRA--REVETL 857
NA+++ R+L E+ Q+ R +R L+E ++ A REV L
Sbjct: 1883 -----------NARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNAL 1931
Query: 858 RQEHR 862
+ + R
Sbjct: 1932 KSKLR 1936
Score = 115 bits (287), Expect = 3e-25
Identities = 228/1040 (21%), Positives = 425/1040 (40%), Gaps = 186/1040 (17%)
Query: 33 QMHVKMCKKIAQLTKVIYALNTRQDEAE--------------ASMEALREAHQEE----- 73
+M V++ K +L ++++ + R +E E M L E +EE
Sbjct: 915 EMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQ 974
Query: 74 ---LQNAVAETKARLLQEQGCA----------EEEALLQRIQALESAL----ELQKRLTE 116
L+ AE K + L+++ E + L +RI L + L E K LT+
Sbjct: 975 KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTK 1034
Query: 117 -----EALAESASCRLETKERELRVEAEHAERVLT-----LSREMLELKADYERRLQHLT 166
E++ RL+ KE + R E E +R L ++ +L+A L
Sbjct: 1035 LKNKHESMISELEVRLK-KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLA 1093
Query: 167 SHEATPQGRLPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYARKAEELQATYE 226
E Q L + E + +++E+ + L+ E+ + KAE+ +
Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ-EDLDSERAARNKAEKQKRDLG 1152
Query: 227 RENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEHRGRK---- 282
E EA++ ++ ++ Q QE + + V + AL + R E ++ +K
Sbjct: 1153 EELEALKTELEDTLDSTATQ-QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1211
Query: 283 ISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECR---- 338
+ +L + ++ K +LD + +EN++L G + LG+ + + E +
Sbjct: 1212 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1271
Query: 339 GTQQTDAMKTELVSENKVLREENDLEA--GNLHPQQDQSCLKECPCMKGGTDMQTKKEAS 396
++ +D + +KV + +N++E+ G L+ + ++ + +Q +E
Sbjct: 1272 QSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL 1331
Query: 397 AETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDLVKKHTVE--IKSVRSSVEAER 454
E K LR Q EEE+ L+DQL + +E K +E I ++ + +
Sbjct: 1332 QEETRQKLNVSTKLR----QLEEERNSLQDQLDEEME---AKQNLERHISTLNIQLSDSK 1384
Query: 455 KKLQ---REVEAQLEEVRKKSEKEIKQLE---EEKAALNVKLQNSLLEVLR-LEEFIQQN 507
KKLQ VEA LEE +K+ +KEI+ L EEKAA KL+ + + + L++ +
Sbjct: 1385 KKLQDFASTVEA-LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDL 1443
Query: 508 KTRPTGAEESPQELGRQHCSILETQDPCLKLDETSPRGE-EYQDK--------LAAEEGT 558
+ ++ + + E ++ K + R E E ++K A EE
Sbjct: 1444 DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL 1503
Query: 559 SSDEE-ERTKVLLK------------------EGSDPQPPLGSLLKEKTSKIQRLEEDWQ 599
+ EE ERT +LK E + L + ++E ++++ LE++ Q
Sbjct: 1504 EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1563
Query: 600 S-QKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQRELQE------TTQQN 652
+ + AKL+ +V+ QAL+ + DLQA + ++ +R +LQR+L E ++
Sbjct: 1564 ATEDAKLRLEVNM--QALK---GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1618
Query: 653 HAMKAQLEASHQRALRMLEKARHQELKATEERLKKESSHSLQIQHQTHRLELQAL----- 707
A+ A + + L+ LE +K EE +K+ LQ Q + + EL+
Sbjct: 1619 RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQ--LRKLQAQMKDFQRELEDARASRD 1676
Query: 708 ---------EEKARQ------ELQEE---RERMQAQQALLLESLRQELSEQ--------- 740
E+KA+ +LQE+ ER + Q L E L +EL+
Sbjct: 1677 EIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQD 1736
Query: 741 -----QAACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPG 795
+A + +++LE Q + A+ + + + + +ATE
Sbjct: 1737 EKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER-----------S 1785
Query: 796 AAGQGSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRAREVE 855
A + L +N +L+ + + V+ K + LE A+ A+ E
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVK------SKFKSTIAALE----AKIAQLEE 1835
Query: 856 TLRQEHRKEMQAMVADFSSAQAQLQARLAALEAELK---DSGEKPGKGASRPEDLQLIGR 912
+ QE R E QA +L+ L +E E K E+ KG +R + +
Sbjct: 1836 QVEQEAR-EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNAR------VKQ 1888
Query: 913 LQTRLKEREDIIKQLTEERR 932
L+ +L+E E+ +++ RR
Sbjct: 1889 LKRQLEEAEEESQRINANRR 1908
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 125 bits (313), Expect = 3e-28
Identities = 188/896 (20%), Positives = 393/896 (43%), Gaps = 118/896 (13%)
Query: 54 TRQDEAEASMEALREAHQEELQNAVAETKARLLQEQGCAEEEALLQRIQALESALELQKR 113
TRQ+E +A ++ELQ +TK R Q AE E L+ ++ S L +K
Sbjct: 848 TRQEEE-------MQAKEDELQ----KTKER----QQKAENE--LKELEQKHSQLTEEKN 890
Query: 114 LTEEALAESASCRLETKERELRVEAEHAERVLTLSREMLELKADYERRLQHLTSHEATPQ 173
L +E L E +E +R+ A+ +E+ E+ + E RL+ +
Sbjct: 891 LLQEQLQAETELYAEAEEMRVRLAAK--------KQELEEILHEMEARLEE-------EE 935
Query: 174 GRLPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYA----RKAEELQATYEREN 229
R Q E K Q +++E L E + R + QL K A +K E+ + +N
Sbjct: 936 DRGQQLQAERKKMAQQMLDLEEQLEEEEAAR-QKLQLEKVTAEAKIKKLEDEILVMDDQN 994
Query: 230 EAI---RQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEHRGRKISDL 286
+ R+ +++ +S E+E + KN ++ ++ + +LE L+ + +L
Sbjct: 995 NKLSKERKLLEERISDLTTNLAEEE-EKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL 1053
Query: 287 KKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECRGTQQTDAM 346
+K +KL+ D Q+ + + + +ELK K E+L A R+ + Q+ +A+
Sbjct: 1054 EKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL---DDEIAQKNNAL 1110
Query: 347 K--TELVSENKVLREENDLE--AGNLHPQQDQSCLKECPCMKGGTDMQTKKEASAETEYM 402
K EL L+E+ D E A N +Q + +E +K T+++ +++A + +
Sbjct: 1111 KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALK--TELEDTLDSTATQQEL 1168
Query: 403 KQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERKKLQREVE 462
+ + E+++ +K +EE + + Q ++++ +KH ++ + +E ++ +
Sbjct: 1169 RAKREQEVTVLKKALDEETRSHEAQ----VQEMRQKHAQAVEELTEQLEQFKR-----AK 1219
Query: 463 AQLEEVRKKSEKEIKQLEEEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEESPQELG 522
A L++ ++ EKE L E L Q + +LE +Q+ +++ + E + EL
Sbjct: 1220 ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELN 1279
Query: 523 -RQHCSILETQDPCLKLDETSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLG 581
+ H E + L+E + + +A+ D +E + ++ + L
Sbjct: 1280 DKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLR 1339
Query: 582 SLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKL 641
L +E+ S +L+E+ ++ K L+ +S + L ++ ++ L + +++
Sbjct: 1340 QLEEERNSLQDQLDEEMEA-KQNLERHISTLNIQLSDSKKKLQDFASTVEALEE-GKKRF 1397
Query: 642 QRELQETTQQNHAMKAQLEASHQRALRMLEKARHQELKATEERLKKESSHSLQIQHQTHR 701
Q+E++ TQQ + A + +L+ T+ RL++E L + R
Sbjct: 1398 QKEIENLTQQYEE----------------KAAAYDKLEKTKNRLQQELD-DLVVDLDNQR 1440
Query: 702 LELQALEEKARQ--ELQEERERMQAQQALLLESLRQELSEQQAACSGHQKDL-EALQAEL 758
+ LE+K R+ +L E + + ++ A + E E++ + L EAL+A+
Sbjct: 1441 QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKE 1500
Query: 759 RALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGAAGQGSGEGCGLWEENAQLQDAV 818
++ + + +D + + ++ G + +L+ +
Sbjct: 1501 EL---ERTNKMLKAEMEDLVSSKDDVG-----------------------KNVHELEKSK 1534
Query: 819 RRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRAREV--ETLRQEHRKEMQAMVADFSSAQ 876
R L ++E+ + + ++L D+ L+ T+ A+ EV + L+ + +++QA +
Sbjct: 1535 RALETQMEEMKTQLEELEDE---LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKR 1591
Query: 877 AQLQARLAALEAELKDSGEKPGKGASRPEDLQ-----LIGRLQTRLKEREDIIKQL 927
QLQ +L E EL+D ++ A+ + L+ L + + +K RE+ IKQL
Sbjct: 1592 RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL 1647
Score = 116 bits (290), Expect = 1e-25
Identities = 199/905 (21%), Positives = 372/905 (41%), Gaps = 130/905 (14%)
Query: 33 QMHVKMCKKIAQLTKVIYALNTRQDEAEASMEALRE--AHQEELQNAV---------AET 81
++ +++ KK +L + L+ + +++ +RE H +LQ + AE
Sbjct: 1080 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1139
Query: 82 KARLLQEQGCAEEEALLQRIQALESALELQKRLTEEALAESASCRLETKERELRVEA--- 138
+ R L E+ A + L + + + EL+ + +E + ET+ E +V+
Sbjct: 1140 QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ 1199
Query: 139 EHAERVLTLSREMLELK---ADYERRLQHLTSHEATPQGRL------PQESPETKSE-PG 188
+HA+ V L+ ++ + K A+ ++ Q L A G L QE K +
Sbjct: 1200 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA 1259
Query: 189 QGPEMQEVLLEVQRLRVENQ-------------------------QLSKDYARKAEELQA 223
Q E+Q + +R R E +L+KD A + +LQ
Sbjct: 1260 QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1319
Query: 224 TYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEHRGRKI 283
T E E RQ + +VS L Q +E+ + L+ + A Q LE + ++
Sbjct: 1320 TQELLQEETRQKL--NVSTKLRQLEEERNSLQDQLDEEMEAKQ----NLERHISTLNIQL 1373
Query: 284 SDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECRGTQQT 343
SD KK Q ++ L+ K ++E L + E+ A A D++ + R Q+
Sbjct: 1374 SDSKKKLQDFASTVEALEEGKKRFQKEIENLT----QQYEEKAAAYDKLEKTKNRLQQEL 1429
Query: 344 DAMKTELVSENKVLREENDLEAGNLHPQQ---DQSCLKECPCMKGGTDMQTKKEASAETE 400
D + +L ++ +++ NL +Q DQ +E D + + EA A +
Sbjct: 1430 DDLVVDLDNQRQLV--------SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1481
Query: 401 YMKQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERKKLQRE 460
K + + +EE + L +EDLV K+V E +K +R
Sbjct: 1482 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH-----ELEKSKRA 1536
Query: 461 VEAQLEEVRKKSEK---EIKQLEEEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEES 517
+E Q+EE++ + E+ E++ E+ K L V +Q +F + + R EE
Sbjct: 1537 LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ------ALKGQFERDLQARDEQNEEK 1590
Query: 518 PQELGRQHCSILETQDPCLKLDETSPRGEEYQDKLAAE-----EGTSSDEEERTKVLLKE 572
++L RQ L ET E Q LAA EG D E + +K
Sbjct: 1591 RRQLQRQ-----------LHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKG 1639
Query: 573 GSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQQ---ALEQCTSNYREDLQA 629
+ L L + + QR ED ++ + ++ A + ++ +LE +EDL A
Sbjct: 1640 REEAIKQLRKL-QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1698
Query: 630 LKQL---SDLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLEKARHQE--LKATEER 684
++ +DLE+E+L EL + +A++ + R ++ E+ ++ ++A +R
Sbjct: 1699 AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDR 1758
Query: 685 LKKESSHSLQIQHQ--THRLELQALEEKARQELQEERERMQAQQALLLESLRQELSEQQA 742
++K + + Q+ ++ T R Q E ARQ+L+ + + ++++ + +++ + A
Sbjct: 1759 VRKATQQAEQLSNELATERSTAQK-NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIA 1817
Query: 743 ACSGHQKDLEALQAELRALGRQQASS---QCPGDSKDHIIATEERGGPGQAGSPPGAAGQ 799
A LE Q E A +Q A+ Q K+ ++ E+ + G
Sbjct: 1818 ALEAKIAQLEE-QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKG- 1875
Query: 800 GSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRA--REVETL 857
NA+++ R+L E+ Q+ R +R L+E ++ A REV L
Sbjct: 1876 -----------NARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNAL 1924
Query: 858 RQEHR 862
+ + R
Sbjct: 1925 KSKLR 1929
Score = 115 bits (287), Expect = 3e-25
Identities = 228/1040 (21%), Positives = 425/1040 (40%), Gaps = 186/1040 (17%)
Query: 33 QMHVKMCKKIAQLTKVIYALNTRQDEAE--------------ASMEALREAHQEE----- 73
+M V++ K +L ++++ + R +E E M L E +EE
Sbjct: 908 EMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQ 967
Query: 74 ---LQNAVAETKARLLQEQGCA----------EEEALLQRIQALESAL----ELQKRLTE 116
L+ AE K + L+++ E + L +RI L + L E K LT+
Sbjct: 968 KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTK 1027
Query: 117 -----EALAESASCRLETKERELRVEAEHAERVLT-----LSREMLELKADYERRLQHLT 166
E++ RL+ KE + R E E +R L ++ +L+A L
Sbjct: 1028 LKNKHESMISELEVRLK-KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLA 1086
Query: 167 SHEATPQGRLPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYARKAEELQATYE 226
E Q L + E + +++E+ + L+ E+ + KAE+ +
Sbjct: 1087 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ-EDLDSERAARNKAEKQKRDLG 1145
Query: 227 RENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEHRGRK---- 282
E EA++ ++ ++ Q QE + + V + AL + R E ++ +K
Sbjct: 1146 EELEALKTELEDTLDSTATQ-QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1204
Query: 283 ISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECR---- 338
+ +L + ++ K +LD + +EN++L G + LG+ + + E +
Sbjct: 1205 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1264
Query: 339 GTQQTDAMKTELVSENKVLREENDLEA--GNLHPQQDQSCLKECPCMKGGTDMQTKKEAS 396
++ +D + +KV + +N++E+ G L+ + ++ + +Q +E
Sbjct: 1265 QSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL 1324
Query: 397 AETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDLVKKHTVE--IKSVRSSVEAER 454
E K LR Q EEE+ L+DQL + +E K +E I ++ + +
Sbjct: 1325 QEETRQKLNVSTKLR----QLEEERNSLQDQLDEEME---AKQNLERHISTLNIQLSDSK 1377
Query: 455 KKLQ---REVEAQLEEVRKKSEKEIKQLE---EEKAALNVKLQNSLLEVLR-LEEFIQQN 507
KKLQ VEA LEE +K+ +KEI+ L EEKAA KL+ + + + L++ +
Sbjct: 1378 KKLQDFASTVEA-LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDL 1436
Query: 508 KTRPTGAEESPQELGRQHCSILETQDPCLKLDETSPRGE-EYQDK--------LAAEEGT 558
+ ++ + + E ++ K + R E E ++K A EE
Sbjct: 1437 DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL 1496
Query: 559 SSDEE-ERTKVLLK------------------EGSDPQPPLGSLLKEKTSKIQRLEEDWQ 599
+ EE ERT +LK E + L + ++E ++++ LE++ Q
Sbjct: 1497 EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1556
Query: 600 S-QKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQRELQE------TTQQN 652
+ + AKL+ +V+ QAL+ + DLQA + ++ +R +LQR+L E ++
Sbjct: 1557 ATEDAKLRLEVNM--QALK---GQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1611
Query: 653 HAMKAQLEASHQRALRMLEKARHQELKATEERLKKESSHSLQIQHQTHRLELQAL----- 707
A+ A + + L+ LE +K EE +K+ LQ Q + + EL+
Sbjct: 1612 RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQ--LRKLQAQMKDFQRELEDARASRD 1669
Query: 708 ---------EEKARQ------ELQEE---RERMQAQQALLLESLRQELSEQ--------- 740
E+KA+ +LQE+ ER + Q L E L +EL+
Sbjct: 1670 EIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQD 1729
Query: 741 -----QAACSGHQKDLEALQAELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPG 795
+A + +++LE Q + A+ + + + + +ATE
Sbjct: 1730 EKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATER-----------S 1778
Query: 796 AAGQGSGEGCGLWEENAQLQDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRAREVE 855
A + L +N +L+ + + V+ K + LE A+ A+ E
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVK------SKFKSTIAALE----AKIAQLEE 1828
Query: 856 TLRQEHRKEMQAMVADFSSAQAQLQARLAALEAELK---DSGEKPGKGASRPEDLQLIGR 912
+ QE R E QA +L+ L +E E K E+ KG +R + +
Sbjct: 1829 QVEQEAR-EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNAR------VKQ 1881
Query: 913 LQTRLKEREDIIKQLTEERR 932
L+ +L+E E+ +++ RR
Sbjct: 1882 LKRQLEEAEEESQRINANRR 1901
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.308 0.124 0.332
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,997,684
Number of Sequences: 37866
Number of extensions: 1967991
Number of successful extensions: 34497
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 510
Number of HSP's successfully gapped in prelim test: 1565
Number of HSP's that attempted gapping in prelim test: 12684
Number of HSP's gapped (non-prelim): 10343
length of query: 1060
length of database: 18,247,518
effective HSP length: 113
effective length of query: 947
effective length of database: 13,968,660
effective search space: 13228321020
effective search space used: 13228321020
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.