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Search of human proteins with 20986516
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|20986516 mitogen-activated protein kinase 14 isoform 4 [Homo
sapiens]
(307 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|20986516 mitogen-activated protein kinase 14 isoform 4 [Homo ... 629 e-180
gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo ... 518 e-147
gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo ... 518 e-147
gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo s... 493 e-140
gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens] 427 e-120
gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens] 365 e-101
gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens] 351 5e-97
gi|21237739 mitogen-activated protein kinase 9 isoform JNK2 alph... 277 1e-74
gi|21237736 mitogen-activated protein kinase 9 isoform JNK2 alph... 277 1e-74
gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta... 276 1e-74
gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta... 276 1e-74
gi|21237745 mitogen-activated protein kinase 9 isoform JNK2 beta... 276 2e-74
gi|21237742 mitogen-activated protein kinase 9 isoform JNK2 beta... 276 2e-74
gi|20986523 mitogen-activated protein kinase 8 isoform JNK1 alph... 269 3e-72
gi|4506095 mitogen-activated protein kinase 8 isoform JNK1 alpha... 269 3e-72
gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo s... 267 1e-71
gi|20986510 mitogen-activated protein kinase 10 isoform 2 [Homo ... 267 1e-71
gi|20986506 mitogen-activated protein kinase 10 isoform 3 [Homo ... 267 1e-71
gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens] 255 4e-68
gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens] 255 4e-68
gi|205277412 mitogen-activated protein kinase 9 isoform JNK2 gam... 254 9e-68
gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo s... 247 8e-66
gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo s... 247 8e-66
gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo s... 246 1e-65
gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo ... 246 1e-65
gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo ... 246 1e-65
gi|158138507 mitogen-activated protein kinase 3 isoform 3 [Homo ... 241 8e-64
gi|149408126 nemo like kinase [Homo sapiens] 219 2e-57
gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens] 193 2e-49
gi|4506091 mitogen-activated protein kinase 6 [Homo sapiens] 184 7e-47
>gi|20986516 mitogen-activated protein kinase 14 isoform 4 [Homo
sapiens]
Length = 307
Score = 629 bits (1622), Expect = e-180
Identities = 307/307 (100%), Positives = 307/307 (100%)
Query: 1 MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ 60
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
Sbjct: 1 MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ 60
Query: 61 SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
Sbjct: 61 SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120
Query: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT 180
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
Sbjct: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT 180
Query: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG 240
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
Sbjct: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG 240
Query: 241 TPGAELLKKISSESLSTCWRRCLYWTQIRELQRPKPLHMPTLLSTTILMMNQWPILMISP 300
TPGAELLKKISSESLSTCWRRCLYWTQIRELQRPKPLHMPTLLSTTILMMNQWPILMISP
Sbjct: 241 TPGAELLKKISSESLSTCWRRCLYWTQIRELQRPKPLHMPTLLSTTILMMNQWPILMISP 300
Query: 301 LKAGTSL 307
LKAGTSL
Sbjct: 301 LKAGTSL 307
>gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo
sapiens]
Length = 297
Score = 518 bits (1333), Expect = e-147
Identities = 254/254 (100%), Positives = 254/254 (100%)
Query: 1 MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ 60
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
Sbjct: 1 MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ 60
Query: 61 SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
Sbjct: 61 SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120
Query: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT 180
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
Sbjct: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT 180
Query: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG 240
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
Sbjct: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG 240
Query: 241 TPGAELLKKISSES 254
TPGAELLKKISSES
Sbjct: 241 TPGAELLKKISSES 254
>gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo
sapiens]
Length = 360
Score = 518 bits (1333), Expect = e-147
Identities = 254/254 (100%), Positives = 254/254 (100%)
Query: 1 MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ 60
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
Sbjct: 1 MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ 60
Query: 61 SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
Sbjct: 61 SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120
Query: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT 180
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
Sbjct: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT 180
Query: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG 240
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
Sbjct: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG 240
Query: 241 TPGAELLKKISSES 254
TPGAELLKKISSES
Sbjct: 241 TPGAELLKKISSES 254
>gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo
sapiens]
Length = 360
Score = 493 bits (1270), Expect = e-140
Identities = 240/252 (95%), Positives = 246/252 (97%)
Query: 1 MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ 60
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
Sbjct: 1 MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ 60
Query: 61 SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
Sbjct: 61 SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120
Query: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT 180
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
Sbjct: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT 180
Query: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG 240
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHI+QL+ I+RL G
Sbjct: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTG 240
Query: 241 TPGAELLKKISS 252
TP A L+ ++ S
Sbjct: 241 TPPAYLINRMPS 252
>gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens]
Length = 364
Score = 427 bits (1098), Expect = e-120
Identities = 204/257 (79%), Positives = 230/257 (89%)
Query: 1 MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ 60
MS R FYRQELNKT+WEVP+R Q L PVGSGAYGSVC+A+D + +VAVKKLSRPFQ
Sbjct: 1 MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ 60
Query: 61 SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120
S+IHA+RTYRELRLLKH+KHENVIGLLDVFTPA S+E+F++VYLVT LMGADLNNIVKCQ
Sbjct: 61 SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ 120
Query: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT 180
L+D+HVQFL+YQ+LRGLKYIHSA IIHRDLKPSN+AVNEDCEL+ILDFGLAR D+EMT
Sbjct: 121 ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT 180
Query: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG 240
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELL G+ LFPG+D+IDQLK I+ +VG
Sbjct: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVG 240
Query: 241 TPGAELLKKISSESLST 257
TP E+L KISSE T
Sbjct: 241 TPSPEVLAKISSEHART 257
>gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens]
Length = 367
Score = 365 bits (937), Expect = e-101
Identities = 169/249 (67%), Positives = 207/249 (83%)
Query: 5 RPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIH 64
R FYRQE+ KT WEV Y++L PVGSGAYG+VC+A D +TG +VA+KKL RPFQS +
Sbjct: 8 RSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELF 67
Query: 65 AKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTD 124
AKR YRELRLLKHM+HENVIGLLDVFTP +L++F D YLV MG DL ++K +KL +
Sbjct: 68 AKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGE 127
Query: 125 DHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVA 184
D +QFL+YQ+L+GL+YIH+A IIHRDLKP NLAVNEDCELKILDFGLAR D EMTGYV
Sbjct: 128 DRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVV 187
Query: 185 TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGA 244
TRWYRAPE++LNWM Y QTVDIWSVGCIMAE++TG+TLF G+DH+DQLK I+++ GTP A
Sbjct: 188 TRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPA 247
Query: 245 ELLKKISSE 253
E ++++ S+
Sbjct: 248 EFVQRLQSD 256
>gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens]
Length = 365
Score = 351 bits (900), Expect = 5e-97
Identities = 164/247 (66%), Positives = 204/247 (82%), Gaps = 1/247 (0%)
Query: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67
FY+Q++NKT WE+P+ Y + + VGSGAYGSVC+A D ++G +VA+KKLSRPFQS I AKR
Sbjct: 9 FYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKR 68
Query: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127
YREL LLKHM+HENVIGLLDVFTPA SL F D YLV M DL I+ + +++ +
Sbjct: 69 AYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME-FSEEKI 127
Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRW 187
Q+L+YQ+L+GLKYIHSA ++HRDLKP NLAVNEDCELKILDFGLARH D EMTGYV TRW
Sbjct: 128 QYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRW 187
Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELL 247
YRAPE++L+WMHYNQTVDIWSVGCIMAE+LTG+TLF G D++DQL IL++ G PG E +
Sbjct: 188 YRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFV 247
Query: 248 KKISSES 254
+K++ ++
Sbjct: 248 QKLNDKA 254
>gi|21237739 mitogen-activated protein kinase 9 isoform JNK2 alpha1
[Homo sapiens]
Length = 382
Score = 277 bits (708), Expect = 1e-74
Identities = 141/245 (57%), Positives = 180/245 (73%), Gaps = 4/245 (1%)
Query: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67
FY ++ + + V +RYQ L P+GSGA G VCAAFDT G+ VAVKKLSRPFQ+ HAKR
Sbjct: 10 FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 69
Query: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127
YREL LLK + H+N+I LL+VFTP ++LEEF DVYLV LM A+L ++ +L + +
Sbjct: 70 AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH-MELDHERM 128
Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMTGYVAT 185
+L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T+ MT YV T
Sbjct: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVT 188
Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245
R+YRAPE++L M Y + VDIWSVGCIM EL+ G +F GTDHIDQ ++ +GTP AE
Sbjct: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAE 247
Query: 246 LLKKI 250
+KK+
Sbjct: 248 FMKKL 252
>gi|21237736 mitogen-activated protein kinase 9 isoform JNK2 alpha2
[Homo sapiens]
Length = 424
Score = 277 bits (708), Expect = 1e-74
Identities = 141/245 (57%), Positives = 180/245 (73%), Gaps = 4/245 (1%)
Query: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67
FY ++ + + V +RYQ L P+GSGA G VCAAFDT G+ VAVKKLSRPFQ+ HAKR
Sbjct: 10 FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 69
Query: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127
YREL LLK + H+N+I LL+VFTP ++LEEF DVYLV LM A+L ++ +L + +
Sbjct: 70 AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH-MELDHERM 128
Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMTGYVAT 185
+L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T+ MT YV T
Sbjct: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVT 188
Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245
R+YRAPE++L M Y + VDIWSVGCIM EL+ G +F GTDHIDQ ++ +GTP AE
Sbjct: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAE 247
Query: 246 LLKKI 250
+KK+
Sbjct: 248 FMKKL 252
>gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta2
[Homo sapiens]
Length = 427
Score = 276 bits (707), Expect = 1e-74
Identities = 140/251 (55%), Positives = 181/251 (72%), Gaps = 4/251 (1%)
Query: 2 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61
S+ FY E+ + + V +RYQNL P+GSGA G VCAA+D VA+KKLSRPFQ+
Sbjct: 4 SKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQN 63
Query: 62 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 121
HAKR YREL L+K + H+N+IGLL+VFTP +SLEEF DVY+V LM A+L +++ +
Sbjct: 64 QTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ-ME 122
Query: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEM 179
L + + +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T M
Sbjct: 123 LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM 182
Query: 180 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLV 239
T YV TR+YRAPE++L M Y + VDIWSVGCIM E++ G LFPGTDHIDQ ++ +
Sbjct: 183 TPYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQL 241
Query: 240 GTPGAELLKKI 250
GTP E +KK+
Sbjct: 242 GTPCPEFMKKL 252
>gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta1
[Homo sapiens]
Length = 384
Score = 276 bits (707), Expect = 1e-74
Identities = 140/251 (55%), Positives = 181/251 (72%), Gaps = 4/251 (1%)
Query: 2 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61
S+ FY E+ + + V +RYQNL P+GSGA G VCAA+D VA+KKLSRPFQ+
Sbjct: 4 SKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQN 63
Query: 62 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 121
HAKR YREL L+K + H+N+IGLL+VFTP +SLEEF DVY+V LM A+L +++ +
Sbjct: 64 QTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ-ME 122
Query: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEM 179
L + + +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T M
Sbjct: 123 LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM 182
Query: 180 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLV 239
T YV TR+YRAPE++L M Y + VDIWSVGCIM E++ G LFPGTDHIDQ ++ +
Sbjct: 183 TPYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQL 241
Query: 240 GTPGAELLKKI 250
GTP E +KK+
Sbjct: 242 GTPCPEFMKKL 252
>gi|21237745 mitogen-activated protein kinase 9 isoform JNK2 beta2
[Homo sapiens]
Length = 424
Score = 276 bits (705), Expect = 2e-74
Identities = 140/245 (57%), Positives = 181/245 (73%), Gaps = 4/245 (1%)
Query: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67
FY ++ + + V +RYQ L P+GSGA G VCAAFDT G+ VAVKKLSRPFQ+ HAKR
Sbjct: 10 FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 69
Query: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127
YREL LLK + H+N+I LL+VFTP ++LEEF DVYLV LM A+L ++ +L + +
Sbjct: 70 AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH-MELDHERM 128
Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMTGYVAT 185
+L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T+ MT YV T
Sbjct: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVT 188
Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245
R+YRAPE++L M Y + VDIWSVGCIMAE++ + LFPG D+IDQ ++ +GTP AE
Sbjct: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAE 247
Query: 246 LLKKI 250
+KK+
Sbjct: 248 FMKKL 252
>gi|21237742 mitogen-activated protein kinase 9 isoform JNK2 beta1
[Homo sapiens]
Length = 382
Score = 276 bits (705), Expect = 2e-74
Identities = 140/245 (57%), Positives = 181/245 (73%), Gaps = 4/245 (1%)
Query: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67
FY ++ + + V +RYQ L P+GSGA G VCAAFDT G+ VAVKKLSRPFQ+ HAKR
Sbjct: 10 FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 69
Query: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127
YREL LLK + H+N+I LL+VFTP ++LEEF DVYLV LM A+L ++ +L + +
Sbjct: 70 AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH-MELDHERM 128
Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMTGYVAT 185
+L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T+ MT YV T
Sbjct: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVT 188
Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245
R+YRAPE++L M Y + VDIWSVGCIMAE++ + LFPG D+IDQ ++ +GTP AE
Sbjct: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAE 247
Query: 246 LLKKI 250
+KK+
Sbjct: 248 FMKKL 252
>gi|20986523 mitogen-activated protein kinase 8 isoform JNK1 alpha2
[Homo sapiens]
Length = 427
Score = 269 bits (687), Expect = 3e-72
Identities = 136/251 (54%), Positives = 180/251 (71%), Gaps = 4/251 (1%)
Query: 2 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61
S+ FY E+ + + V +RYQNL P+GSGA G VCAA+D VA+KKLSRPFQ+
Sbjct: 4 SKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQN 63
Query: 62 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 121
HAKR YREL L+K + H+N+IGLL+VFTP +SLEEF DVY+V LM A+L +++ +
Sbjct: 64 QTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ-ME 122
Query: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEM 179
L + + +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T M
Sbjct: 123 LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM 182
Query: 180 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLV 239
T YV TR+YRAPE++L M Y + VD+WSVGCIM E++ + LFPG D+IDQ ++ +
Sbjct: 183 TPYVVTRYYRAPEVILG-MGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQL 241
Query: 240 GTPGAELLKKI 250
GTP E +KK+
Sbjct: 242 GTPCPEFMKKL 252
>gi|4506095 mitogen-activated protein kinase 8 isoform JNK1 alpha1
[Homo sapiens]
Length = 384
Score = 269 bits (687), Expect = 3e-72
Identities = 136/251 (54%), Positives = 180/251 (71%), Gaps = 4/251 (1%)
Query: 2 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61
S+ FY E+ + + V +RYQNL P+GSGA G VCAA+D VA+KKLSRPFQ+
Sbjct: 4 SKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQN 63
Query: 62 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 121
HAKR YREL L+K + H+N+IGLL+VFTP +SLEEF DVY+V LM A+L +++ +
Sbjct: 64 QTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ-ME 122
Query: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEM 179
L + + +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T M
Sbjct: 123 LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM 182
Query: 180 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLV 239
T YV TR+YRAPE++L M Y + VD+WSVGCIM E++ + LFPG D+IDQ ++ +
Sbjct: 183 TPYVVTRYYRAPEVILG-MGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQL 241
Query: 240 GTPGAELLKKI 250
GTP E +KK+
Sbjct: 242 GTPCPEFMKKL 252
>gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo
sapiens]
Length = 422
Score = 267 bits (682), Expect = 1e-71
Identities = 135/245 (55%), Positives = 177/245 (72%), Gaps = 4/245 (1%)
Query: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67
FY E+ + + V +RYQNL P+GSGA G VCAA+D VA+KKLSRPFQ+ HAKR
Sbjct: 48 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107
Query: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127
YREL L+K + H+N+I LL+VFTP ++LEEF DVYLV LM A+L +++ +L + +
Sbjct: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-MELDHERM 166
Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEMTGYVAT 185
+L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T MT YV T
Sbjct: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 226
Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245
R+YRAPE++L M Y + VDIWSVGCIM E++ + LFPG D+IDQ ++ +GTP E
Sbjct: 227 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285
Query: 246 LLKKI 250
+KK+
Sbjct: 286 FMKKL 290
>gi|20986510 mitogen-activated protein kinase 10 isoform 2 [Homo
sapiens]
Length = 464
Score = 267 bits (682), Expect = 1e-71
Identities = 135/245 (55%), Positives = 177/245 (72%), Gaps = 4/245 (1%)
Query: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67
FY E+ + + V +RYQNL P+GSGA G VCAA+D VA+KKLSRPFQ+ HAKR
Sbjct: 48 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107
Query: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127
YREL L+K + H+N+I LL+VFTP ++LEEF DVYLV LM A+L +++ +L + +
Sbjct: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-MELDHERM 166
Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEMTGYVAT 185
+L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T MT YV T
Sbjct: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 226
Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245
R+YRAPE++L M Y + VDIWSVGCIM E++ + LFPG D+IDQ ++ +GTP E
Sbjct: 227 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285
Query: 246 LLKKI 250
+KK+
Sbjct: 286 FMKKL 290
>gi|20986506 mitogen-activated protein kinase 10 isoform 3 [Homo
sapiens]
Length = 426
Score = 267 bits (682), Expect = 1e-71
Identities = 135/245 (55%), Positives = 177/245 (72%), Gaps = 4/245 (1%)
Query: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67
FY E+ + + V +RYQNL P+GSGA G VCAA+D VA+KKLSRPFQ+ HAKR
Sbjct: 10 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 69
Query: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127
YREL L+K + H+N+I LL+VFTP ++LEEF DVYLV LM A+L +++ +L + +
Sbjct: 70 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-MELDHERM 128
Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEMTGYVAT 185
+L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T MT YV T
Sbjct: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 188
Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245
R+YRAPE++L M Y + VDIWSVGCIM E++ + LFPG D+IDQ ++ +GTP E
Sbjct: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 247
Query: 246 LLKKI 250
+KK+
Sbjct: 248 FMKKL 252
>gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens]
Length = 360
Score = 255 bits (651), Expect = 4e-68
Identities = 125/240 (52%), Positives = 174/240 (72%), Gaps = 8/240 (3%)
Query: 17 IWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLK 76
+++V RY NLS +G GAYG VC+A+D +RVA+KK+S PF+ + +RT RE+++L
Sbjct: 18 VFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILL 76
Query: 77 HMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILR 136
+HEN+IG+ D+ A ++E+ DVY+V LM DL ++K Q L++DH+ + +YQILR
Sbjct: 77 RFRHENIIGINDIIR-APTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILR 135
Query: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE------MTGYVATRWYRA 190
GLKYIHSA+++HRDLKPSNL +N C+LKI DFGLAR D + +T YVATRWYRA
Sbjct: 136 GLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRA 195
Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKI 250
PEIMLN Y +++DIWSVGCI+AE+L+ R +FPG ++DQL IL ++G+P E L I
Sbjct: 196 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 255
>gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens]
Length = 360
Score = 255 bits (651), Expect = 4e-68
Identities = 125/240 (52%), Positives = 174/240 (72%), Gaps = 8/240 (3%)
Query: 17 IWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLK 76
+++V RY NLS +G GAYG VC+A+D +RVA+KK+S PF+ + +RT RE+++L
Sbjct: 18 VFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILL 76
Query: 77 HMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILR 136
+HEN+IG+ D+ A ++E+ DVY+V LM DL ++K Q L++DH+ + +YQILR
Sbjct: 77 RFRHENIIGINDIIR-APTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILR 135
Query: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE------MTGYVATRWYRA 190
GLKYIHSA+++HRDLKPSNL +N C+LKI DFGLAR D + +T YVATRWYRA
Sbjct: 136 GLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRA 195
Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKI 250
PEIMLN Y +++DIWSVGCI+AE+L+ R +FPG ++DQL IL ++G+P E L I
Sbjct: 196 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 255
>gi|205277412 mitogen-activated protein kinase 9 isoform JNK2 gamma
[Homo sapiens]
Length = 242
Score = 254 bits (648), Expect = 9e-68
Identities = 131/224 (58%), Positives = 165/224 (73%), Gaps = 4/224 (1%)
Query: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67
FY ++ + + V +RYQ L P+GSGA G VCAAFDT G+ VAVKKLSRPFQ+ HAKR
Sbjct: 10 FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 69
Query: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127
YREL LLK + H+N+I LL+VFTP ++LEEF DVYLV LM A+L ++ +L + +
Sbjct: 70 AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH-MELDHERM 128
Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMTGYVAT 185
+L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T+ MT YV T
Sbjct: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVT 188
Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHI 229
R+YRAPE++L M Y + VDIWSVGCIM EL+ G +F GTD I
Sbjct: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMGELVKGCVIFQGTDRI 231
>gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo
sapiens]
Length = 357
Score = 247 bits (631), Expect = 8e-66
Identities = 125/239 (52%), Positives = 169/239 (70%), Gaps = 8/239 (3%)
Query: 18 WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 77
++V RY L +G GAYG V +A+D RVA+KK+S PF+ + +RT RE+++L
Sbjct: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94
Query: 78 MKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRG 137
+HENVIG+ D+ A +LE DVY+V LM DL ++K Q+L++DH+ + +YQILRG
Sbjct: 95 FRHENVIGIRDILR-ASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153
Query: 138 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE------MTGYVATRWYRAP 191
LKYIHSA+++HRDLKPSNL +N C+LKI DFGLAR D E +T YVATRWYRAP
Sbjct: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213
Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKI 250
EIMLN Y +++DIWSVGCI+AE+L+ R +FPG ++DQL IL ++G+P E L I
Sbjct: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 272
>gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo
sapiens]
Length = 379
Score = 247 bits (631), Expect = 8e-66
Identities = 125/239 (52%), Positives = 169/239 (70%), Gaps = 8/239 (3%)
Query: 18 WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 77
++V RY L +G GAYG V +A+D RVA+KK+S PF+ + +RT RE+++L
Sbjct: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94
Query: 78 MKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRG 137
+HENVIG+ D+ A +LE DVY+V LM DL ++K Q+L++DH+ + +YQILRG
Sbjct: 95 FRHENVIGIRDILR-ASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153
Query: 138 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE------MTGYVATRWYRAP 191
LKYIHSA+++HRDLKPSNL +N C+LKI DFGLAR D E +T YVATRWYRAP
Sbjct: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213
Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKI 250
EIMLN Y +++DIWSVGCI+AE+L+ R +FPG ++DQL IL ++G+P E L I
Sbjct: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 272
>gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 246 bits (629), Expect = 1e-65
Identities = 120/244 (49%), Positives = 169/244 (69%), Gaps = 8/244 (3%)
Query: 18 WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 77
++V + Y+ + +G+GAYG V +A TG +VA+KK+ F + +AKRT REL++LKH
Sbjct: 49 FDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKH 108
Query: 78 MKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIV-KCQKLTDDHVQFLIYQILR 136
KH+N+I + D+ P EF VY+V LM +DL+ I+ Q LT +HV++ +YQ+LR
Sbjct: 109 FKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLR 168
Query: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE-------MTGYVATRWYR 189
GLKY+HSA +IHRDLKPSNL VNE+CELKI DFG+AR MT YVATRWYR
Sbjct: 169 GLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYR 228
Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKK 249
APE+ML+ Y Q +D+WSVGCI E+L R LFPG +++ QL+LI+ ++GTP +++
Sbjct: 229 APELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQA 288
Query: 250 ISSE 253
+ +E
Sbjct: 289 VGAE 292
>gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 246 bits (629), Expect = 1e-65
Identities = 120/244 (49%), Positives = 169/244 (69%), Gaps = 8/244 (3%)
Query: 18 WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 77
++V + Y+ + +G+GAYG V +A TG +VA+KK+ F + +AKRT REL++LKH
Sbjct: 49 FDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKH 108
Query: 78 MKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIV-KCQKLTDDHVQFLIYQILR 136
KH+N+I + D+ P EF VY+V LM +DL+ I+ Q LT +HV++ +YQ+LR
Sbjct: 109 FKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLR 168
Query: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE-------MTGYVATRWYR 189
GLKY+HSA +IHRDLKPSNL VNE+CELKI DFG+AR MT YVATRWYR
Sbjct: 169 GLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYR 228
Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKK 249
APE+ML+ Y Q +D+WSVGCI E+L R LFPG +++ QL+LI+ ++GTP +++
Sbjct: 229 APELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQA 288
Query: 250 ISSE 253
+ +E
Sbjct: 289 VGAE 292
>gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 246 bits (629), Expect = 1e-65
Identities = 120/244 (49%), Positives = 169/244 (69%), Gaps = 8/244 (3%)
Query: 18 WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 77
++V + Y+ + +G+GAYG V +A TG +VA+KK+ F + +AKRT REL++LKH
Sbjct: 49 FDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKH 108
Query: 78 MKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIV-KCQKLTDDHVQFLIYQILR 136
KH+N+I + D+ P EF VY+V LM +DL+ I+ Q LT +HV++ +YQ+LR
Sbjct: 109 FKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLR 168
Query: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE-------MTGYVATRWYR 189
GLKY+HSA +IHRDLKPSNL VNE+CELKI DFG+AR MT YVATRWYR
Sbjct: 169 GLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYR 228
Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKK 249
APE+ML+ Y Q +D+WSVGCI E+L R LFPG +++ QL+LI+ ++GTP +++
Sbjct: 229 APELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQA 288
Query: 250 ISSE 253
+ +E
Sbjct: 289 VGAE 292
>gi|158138507 mitogen-activated protein kinase 3 isoform 3 [Homo
sapiens]
Length = 335
Score = 241 bits (614), Expect = 8e-64
Identities = 121/227 (53%), Positives = 162/227 (71%), Gaps = 8/227 (3%)
Query: 18 WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 77
++V RY L +G GAYG V +A+D RVA+KK+S PF+ + +RT RE+++L
Sbjct: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94
Query: 78 MKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRG 137
+HENVIG+ D+ A +LE DVY+V LM DL ++K Q+L++DH+ + +YQILRG
Sbjct: 95 FRHENVIGIRDILR-ASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153
Query: 138 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE------MTGYVATRWYRAP 191
LKYIHSA+++HRDLKPSNL +N C+LKI DFGLAR D E +T YVATRWYRAP
Sbjct: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213
Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRL 238
EIMLN Y +++DIWSVGCI+AE+L+ R +FPG ++DQL IL L
Sbjct: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILAL 260
>gi|149408126 nemo like kinase [Homo sapiens]
Length = 527
Score = 219 bits (558), Expect = 2e-57
Identities = 114/225 (50%), Positives = 153/225 (68%), Gaps = 6/225 (2%)
Query: 29 PVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLD 88
P+G GA+G V + D + G RVA+KK+ FQ+++ KR +REL++L KH+NV+ LD
Sbjct: 143 PIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALD 202
Query: 89 VFTPARSLEEFNDVYLVTHLMGADLNNI-VKCQKLTDDHVQFLIYQILRGLKYIHSADII 147
+ P ++ F ++Y+VT LM +DL+ I V Q L+ DHV+ +YQILRGLKY+HSA I+
Sbjct: 203 ILQPPH-IDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGIL 261
Query: 148 HRDLKPSNLAVNEDCELKILDFGLARHTD-DE---MTGYVATRWYRAPEIMLNWMHYNQT 203
HRD+KP NL VN +C LKI DFGLAR + DE MT V T++YRAPEI++ HY+
Sbjct: 262 HRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNA 321
Query: 204 VDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLK 248
+DIWSVGCI AELL R LF I QL LI L+GTP E ++
Sbjct: 322 IDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMR 366
>gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens]
Length = 544
Score = 193 bits (490), Expect = 2e-49
Identities = 105/243 (43%), Positives = 146/243 (60%), Gaps = 14/243 (5%)
Query: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHM- 78
+ RY +G GAYG V A D +TG VA+KK+ F+ A+RT+RE+ LL+
Sbjct: 9 IVRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFG 68
Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDD-HVQFLIYQILRG 137
H N+I LLDV E D+YLV M DLN +++ L D HV+ + YQ+LR
Sbjct: 69 DHPNIISLLDVIRA----ENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRA 124
Query: 138 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT--------DDEMTGYVATRWYR 189
+++HS ++HRD KPSN+ ++ +C +K+ DFGLAR D +T YVATRWYR
Sbjct: 125 TRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYR 184
Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKK 249
APE++L+ Y VD+WS+GCI+ E+L GR LFPGT + QL+LIL + P E L
Sbjct: 185 APEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLA 244
Query: 250 ISS 252
+ S
Sbjct: 245 LGS 247
>gi|4506091 mitogen-activated protein kinase 6 [Homo sapiens]
Length = 721
Score = 184 bits (468), Expect = 7e-47
Identities = 97/239 (40%), Positives = 153/239 (64%), Gaps = 21/239 (8%)
Query: 18 WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKK--LSRPFQSIIHAKRTYRELRLL 75
+++ RY +L P+G G G V +A D RVA+KK L+ P QS+ HA RE++++
Sbjct: 14 FDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDP-QSVKHA---LREIKII 69
Query: 76 KHMKHENVIGLLDVFTPARS--------LEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127
+ + H+N++ + ++ P+ S L E N VY+V M DL N+++ L ++H
Sbjct: 70 RRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHA 129
Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLARHTD------DEMT 180
+ +YQ+LRGLKYIHSA+++HRDLKP+NL +N ED LKI DFGLAR D ++
Sbjct: 130 RLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLS 189
Query: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLV 239
+ T+WYR+P ++L+ +Y + +D+W+ GCI AE+LTG+TLF G ++Q++LIL +
Sbjct: 190 EGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESI 248
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.137 0.426
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,857,726
Number of Sequences: 37866
Number of extensions: 506821
Number of successful extensions: 2904
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 728
Number of HSP's successfully gapped in prelim test: 69
Number of HSP's that attempted gapping in prelim test: 927
Number of HSP's gapped (non-prelim): 894
length of query: 307
length of database: 18,247,518
effective HSP length: 102
effective length of query: 205
effective length of database: 14,385,186
effective search space: 2948963130
effective search space used: 2948963130
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.