BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo sapiens] (297 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo ... 603 e-173 gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo ... 569 e-163 gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo s... 545 e-155 gi|20986516 mitogen-activated protein kinase 14 isoform 4 [Homo ... 518 e-147 gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens] 456 e-129 gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens] 389 e-108 gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens] 375 e-104 gi|21237739 mitogen-activated protein kinase 9 isoform JNK2 alph... 287 7e-78 gi|21237736 mitogen-activated protein kinase 9 isoform JNK2 alph... 287 7e-78 gi|21237745 mitogen-activated protein kinase 9 isoform JNK2 beta... 286 2e-77 gi|21237742 mitogen-activated protein kinase 9 isoform JNK2 beta... 286 2e-77 gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta... 281 5e-76 gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta... 281 5e-76 gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo s... 275 5e-74 gi|20986510 mitogen-activated protein kinase 10 isoform 2 [Homo ... 275 5e-74 gi|20986506 mitogen-activated protein kinase 10 isoform 3 [Homo ... 275 5e-74 gi|20986523 mitogen-activated protein kinase 8 isoform JNK1 alph... 273 1e-73 gi|4506095 mitogen-activated protein kinase 8 isoform JNK1 alpha... 273 1e-73 gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens] 268 3e-72 gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens] 268 3e-72 gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo s... 265 3e-71 gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo s... 265 3e-71 gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo s... 260 1e-69 gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo ... 260 1e-69 gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo ... 260 1e-69 gi|205277412 mitogen-activated protein kinase 9 isoform JNK2 gam... 254 8e-68 gi|158138507 mitogen-activated protein kinase 3 isoform 3 [Homo ... 241 7e-64 gi|149408126 nemo like kinase [Homo sapiens] 220 1e-57 gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens] 196 3e-50 gi|4506091 mitogen-activated protein kinase 6 [Homo sapiens] 184 6e-47 >gi|20986514 mitogen-activated protein kinase 14 isoform 3 [Homo sapiens] Length = 297 Score = 603 bits (1554), Expect = e-173 Identities = 297/297 (100%), Positives = 297/297 (100%) Query: 1 MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ 60 MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ Sbjct: 1 MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ 60 Query: 61 SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120 SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ Sbjct: 61 SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120 Query: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT 180 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT Sbjct: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT 180 Query: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG 240 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG Sbjct: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG 240 Query: 241 TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLGKLTIYPHLMDIELVMI 297 TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLGKLTIYPHLMDIELVMI Sbjct: 241 TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLGKLTIYPHLMDIELVMI 297 >gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo sapiens] Length = 360 Score = 569 bits (1467), Expect = e-163 Identities = 280/280 (100%), Positives = 280/280 (100%) Query: 1 MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ 60 MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ Sbjct: 1 MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ 60 Query: 61 SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120 SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ Sbjct: 61 SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120 Query: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT 180 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT Sbjct: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT 180 Query: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG 240 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG Sbjct: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG 240 Query: 241 TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPL 280 TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPL Sbjct: 241 TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPL 280 >gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo sapiens] Length = 360 Score = 545 bits (1404), Expect = e-155 Identities = 266/280 (95%), Positives = 272/280 (97%) Query: 1 MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ 60 MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ Sbjct: 1 MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ 60 Query: 61 SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120 SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ Sbjct: 61 SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120 Query: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT 180 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT Sbjct: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT 180 Query: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG 240 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHI+QL+ I+RL G Sbjct: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTG 240 Query: 241 TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPL 280 TP A L+ ++ S ARNYIQSLTQMPKMNFANVFIGANPL Sbjct: 241 TPPAYLINRMPSHEARNYIQSLTQMPKMNFANVFIGANPL 280 >gi|20986516 mitogen-activated protein kinase 14 isoform 4 [Homo sapiens] Length = 307 Score = 518 bits (1333), Expect = e-147 Identities = 254/254 (100%), Positives = 254/254 (100%) Query: 1 MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ 60 MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ Sbjct: 1 MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ 60 Query: 61 SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120 SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ Sbjct: 61 SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120 Query: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT 180 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT Sbjct: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT 180 Query: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG 240 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG Sbjct: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG 240 Query: 241 TPGAELLKKISSES 254 TPGAELLKKISSES Sbjct: 241 TPGAELLKKISSES 254 >gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens] Length = 364 Score = 456 bits (1174), Expect = e-129 Identities = 218/280 (77%), Positives = 249/280 (88%) Query: 1 MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ 60 MS R FYRQELNKT+WEVP+R Q L PVGSGAYGSVC+A+D + +VAVKKLSRPFQ Sbjct: 1 MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ 60 Query: 61 SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120 S+IHA+RTYRELRLLKH+KHENVIGLLDVFTPA S+E+F++VYLVT LMGADLNNIVKCQ Sbjct: 61 SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ 120 Query: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT 180 L+D+HVQFL+YQ+LRGLKYIHSA IIHRDLKPSN+AVNEDCEL+ILDFGLAR D+EMT Sbjct: 121 ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT 180 Query: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG 240 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELL G+ LFPG+D+IDQLK I+ +VG Sbjct: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVG 240 Query: 241 TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPL 280 TP E+L KISSE AR YIQSL MP+ + +++F GANPL Sbjct: 241 TPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPL 280 >gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens] Length = 367 Score = 389 bits (998), Expect = e-108 Identities = 179/276 (64%), Positives = 226/276 (81%) Query: 5 RPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIH 64 R FYRQE+ KT WEV Y++L PVGSGAYG+VC+A D +TG +VA+KKL RPFQS + Sbjct: 8 RSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELF 67 Query: 65 AKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTD 124 AKR YRELRLLKHM+HENVIGLLDVFTP +L++F D YLV MG DL ++K +KL + Sbjct: 68 AKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGE 127 Query: 125 DHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVA 184 D +QFL+YQ+L+GL+YIH+A IIHRDLKP NLAVNEDCELKILDFGLAR D EMTGYV Sbjct: 128 DRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVV 187 Query: 185 TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGA 244 TRWYRAPE++LNWM Y QTVDIWSVGCIMAE++TG+TLF G+DH+DQLK I+++ GTP A Sbjct: 188 TRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPA 247 Query: 245 ELLKKISSESARNYIQSLTQMPKMNFANVFIGANPL 280 E ++++ S+ A+NY++ L ++ K +FA++ A+PL Sbjct: 248 EFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPL 283 >gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens] Length = 365 Score = 375 bits (963), Expect = e-104 Identities = 176/272 (64%), Positives = 222/272 (81%), Gaps = 1/272 (0%) Query: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67 FY+Q++NKT WE+P+ Y + + VGSGAYGSVC+A D ++G +VA+KKLSRPFQS I AKR Sbjct: 9 FYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKR 68 Query: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127 YREL LLKHM+HENVIGLLDVFTPA SL F D YLV M DL I+ + +++ + Sbjct: 69 AYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME-FSEEKI 127 Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRW 187 Q+L+YQ+L+GLKYIHSA ++HRDLKP NLAVNEDCELKILDFGLARH D EMTGYV TRW Sbjct: 128 QYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTRW 187 Query: 188 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELL 247 YRAPE++L+WMHYNQTVDIWSVGCIMAE+LTG+TLF G D++DQL IL++ G PG E + Sbjct: 188 YRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFV 247 Query: 248 KKISSESARNYIQSLTQMPKMNFANVFIGANP 279 +K++ ++A++YIQSL Q P+ +F +F A+P Sbjct: 248 QKLNDKAAKSYIQSLPQTPRKDFTQLFPRASP 279 >gi|21237739 mitogen-activated protein kinase 9 isoform JNK2 alpha1 [Homo sapiens] Length = 382 Score = 287 bits (735), Expect = 7e-78 Identities = 147/269 (54%), Positives = 193/269 (71%), Gaps = 5/269 (1%) Query: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67 FY ++ + + V +RYQ L P+GSGA G VCAAFDT G+ VAVKKLSRPFQ+ HAKR Sbjct: 10 FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 69 Query: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127 YREL LLK + H+N+I LL+VFTP ++LEEF DVYLV LM A+L ++ +L + + Sbjct: 70 AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH-MELDHERM 128 Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMTGYVAT 185 +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T+ MT YV T Sbjct: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVT 188 Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245 R+YRAPE++L M Y + VDIWSVGCIM EL+ G +F GTDHIDQ ++ +GTP AE Sbjct: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAE 247 Query: 246 LLKKISSESARNYIQSLTQMPKMNFANVF 274 +KK+ + RNY+++ + P + F +F Sbjct: 248 FMKKL-QPTVRNYVENRPKYPGIKFEELF 275 >gi|21237736 mitogen-activated protein kinase 9 isoform JNK2 alpha2 [Homo sapiens] Length = 424 Score = 287 bits (735), Expect = 7e-78 Identities = 147/269 (54%), Positives = 193/269 (71%), Gaps = 5/269 (1%) Query: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67 FY ++ + + V +RYQ L P+GSGA G VCAAFDT G+ VAVKKLSRPFQ+ HAKR Sbjct: 10 FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 69 Query: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127 YREL LLK + H+N+I LL+VFTP ++LEEF DVYLV LM A+L ++ +L + + Sbjct: 70 AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH-MELDHERM 128 Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMTGYVAT 185 +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T+ MT YV T Sbjct: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVT 188 Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245 R+YRAPE++L M Y + VDIWSVGCIM EL+ G +F GTDHIDQ ++ +GTP AE Sbjct: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAE 247 Query: 246 LLKKISSESARNYIQSLTQMPKMNFANVF 274 +KK+ + RNY+++ + P + F +F Sbjct: 248 FMKKL-QPTVRNYVENRPKYPGIKFEELF 275 >gi|21237745 mitogen-activated protein kinase 9 isoform JNK2 beta2 [Homo sapiens] Length = 424 Score = 286 bits (732), Expect = 2e-77 Identities = 146/269 (54%), Positives = 194/269 (72%), Gaps = 5/269 (1%) Query: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67 FY ++ + + V +RYQ L P+GSGA G VCAAFDT G+ VAVKKLSRPFQ+ HAKR Sbjct: 10 FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 69 Query: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127 YREL LLK + H+N+I LL+VFTP ++LEEF DVYLV LM A+L ++ +L + + Sbjct: 70 AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH-MELDHERM 128 Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMTGYVAT 185 +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T+ MT YV T Sbjct: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVT 188 Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245 R+YRAPE++L M Y + VDIWSVGCIMAE++ + LFPG D+IDQ ++ +GTP AE Sbjct: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAE 247 Query: 246 LLKKISSESARNYIQSLTQMPKMNFANVF 274 +KK+ + RNY+++ + P + F +F Sbjct: 248 FMKKL-QPTVRNYVENRPKYPGIKFEELF 275 >gi|21237742 mitogen-activated protein kinase 9 isoform JNK2 beta1 [Homo sapiens] Length = 382 Score = 286 bits (732), Expect = 2e-77 Identities = 146/269 (54%), Positives = 194/269 (72%), Gaps = 5/269 (1%) Query: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67 FY ++ + + V +RYQ L P+GSGA G VCAAFDT G+ VAVKKLSRPFQ+ HAKR Sbjct: 10 FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 69 Query: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127 YREL LLK + H+N+I LL+VFTP ++LEEF DVYLV LM A+L ++ +L + + Sbjct: 70 AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH-MELDHERM 128 Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMTGYVAT 185 +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T+ MT YV T Sbjct: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVT 188 Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245 R+YRAPE++L M Y + VDIWSVGCIMAE++ + LFPG D+IDQ ++ +GTP AE Sbjct: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAE 247 Query: 246 LLKKISSESARNYIQSLTQMPKMNFANVF 274 +KK+ + RNY+++ + P + F +F Sbjct: 248 FMKKL-QPTVRNYVENRPKYPGIKFEELF 275 >gi|20986521 mitogen-activated protein kinase 8 isoform JNK1 beta2 [Homo sapiens] Length = 427 Score = 281 bits (719), Expect = 5e-76 Identities = 144/275 (52%), Positives = 192/275 (69%), Gaps = 5/275 (1%) Query: 2 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61 S+ FY E+ + + V +RYQNL P+GSGA G VCAA+D VA+KKLSRPFQ+ Sbjct: 4 SKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQN 63 Query: 62 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 121 HAKR YREL L+K + H+N+IGLL+VFTP +SLEEF DVY+V LM A+L +++ + Sbjct: 64 QTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ-ME 122 Query: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEM 179 L + + +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T M Sbjct: 123 LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM 182 Query: 180 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLV 239 T YV TR+YRAPE++L M Y + VDIWSVGCIM E++ G LFPGTDHIDQ ++ + Sbjct: 183 TPYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQL 241 Query: 240 GTPGAELLKKISSESARNYIQSLTQMPKMNFANVF 274 GTP E +KK+ + R Y+++ + +F +F Sbjct: 242 GTPCPEFMKKL-QPTVRTYVENRPKYAGYSFEKLF 275 >gi|20986519 mitogen-activated protein kinase 8 isoform JNK1 beta1 [Homo sapiens] Length = 384 Score = 281 bits (719), Expect = 5e-76 Identities = 144/275 (52%), Positives = 192/275 (69%), Gaps = 5/275 (1%) Query: 2 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61 S+ FY E+ + + V +RYQNL P+GSGA G VCAA+D VA+KKLSRPFQ+ Sbjct: 4 SKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQN 63 Query: 62 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 121 HAKR YREL L+K + H+N+IGLL+VFTP +SLEEF DVY+V LM A+L +++ + Sbjct: 64 QTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ-ME 122 Query: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEM 179 L + + +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T M Sbjct: 123 LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM 182 Query: 180 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLV 239 T YV TR+YRAPE++L M Y + VDIWSVGCIM E++ G LFPGTDHIDQ ++ + Sbjct: 183 TPYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQL 241 Query: 240 GTPGAELLKKISSESARNYIQSLTQMPKMNFANVF 274 GTP E +KK+ + R Y+++ + +F +F Sbjct: 242 GTPCPEFMKKL-QPTVRTYVENRPKYAGYSFEKLF 275 >gi|4506081 mitogen-activated protein kinase 10 isoform 1 [Homo sapiens] Length = 422 Score = 275 bits (702), Expect = 5e-74 Identities = 140/269 (52%), Positives = 189/269 (70%), Gaps = 5/269 (1%) Query: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67 FY E+ + + V +RYQNL P+GSGA G VCAA+D VA+KKLSRPFQ+ HAKR Sbjct: 48 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107 Query: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127 YREL L+K + H+N+I LL+VFTP ++LEEF DVYLV LM A+L +++ +L + + Sbjct: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-MELDHERM 166 Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEMTGYVAT 185 +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T MT YV T Sbjct: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 226 Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245 R+YRAPE++L M Y + VDIWSVGCIM E++ + LFPG D+IDQ ++ +GTP E Sbjct: 227 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285 Query: 246 LLKKISSESARNYIQSLTQMPKMNFANVF 274 +KK+ + RNY+++ + + F +F Sbjct: 286 FMKKL-QPTVRNYVENRPKYAGLTFPKLF 313 >gi|20986510 mitogen-activated protein kinase 10 isoform 2 [Homo sapiens] Length = 464 Score = 275 bits (702), Expect = 5e-74 Identities = 140/269 (52%), Positives = 189/269 (70%), Gaps = 5/269 (1%) Query: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67 FY E+ + + V +RYQNL P+GSGA G VCAA+D VA+KKLSRPFQ+ HAKR Sbjct: 48 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 107 Query: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127 YREL L+K + H+N+I LL+VFTP ++LEEF DVYLV LM A+L +++ +L + + Sbjct: 108 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-MELDHERM 166 Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEMTGYVAT 185 +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T MT YV T Sbjct: 167 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 226 Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245 R+YRAPE++L M Y + VDIWSVGCIM E++ + LFPG D+IDQ ++ +GTP E Sbjct: 227 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285 Query: 246 LLKKISSESARNYIQSLTQMPKMNFANVF 274 +KK+ + RNY+++ + + F +F Sbjct: 286 FMKKL-QPTVRNYVENRPKYAGLTFPKLF 313 >gi|20986506 mitogen-activated protein kinase 10 isoform 3 [Homo sapiens] Length = 426 Score = 275 bits (702), Expect = 5e-74 Identities = 140/269 (52%), Positives = 189/269 (70%), Gaps = 5/269 (1%) Query: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67 FY E+ + + V +RYQNL P+GSGA G VCAA+D VA+KKLSRPFQ+ HAKR Sbjct: 10 FYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKR 69 Query: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127 YREL L+K + H+N+I LL+VFTP ++LEEF DVYLV LM A+L +++ +L + + Sbjct: 70 AYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-MELDHERM 128 Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEMTGYVAT 185 +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T MT YV T Sbjct: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVT 188 Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE 245 R+YRAPE++L M Y + VDIWSVGCIM E++ + LFPG D+IDQ ++ +GTP E Sbjct: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 247 Query: 246 LLKKISSESARNYIQSLTQMPKMNFANVF 274 +KK+ + RNY+++ + + F +F Sbjct: 248 FMKKL-QPTVRNYVENRPKYAGLTFPKLF 275 >gi|20986523 mitogen-activated protein kinase 8 isoform JNK1 alpha2 [Homo sapiens] Length = 427 Score = 273 bits (699), Expect = 1e-73 Identities = 140/275 (50%), Positives = 191/275 (69%), Gaps = 5/275 (1%) Query: 2 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61 S+ FY E+ + + V +RYQNL P+GSGA G VCAA+D VA+KKLSRPFQ+ Sbjct: 4 SKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQN 63 Query: 62 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 121 HAKR YREL L+K + H+N+IGLL+VFTP +SLEEF DVY+V LM A+L +++ + Sbjct: 64 QTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ-ME 122 Query: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEM 179 L + + +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T M Sbjct: 123 LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM 182 Query: 180 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLV 239 T YV TR+YRAPE++L M Y + VD+WSVGCIM E++ + LFPG D+IDQ ++ + Sbjct: 183 TPYVVTRYYRAPEVILG-MGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQL 241 Query: 240 GTPGAELLKKISSESARNYIQSLTQMPKMNFANVF 274 GTP E +KK+ + R Y+++ + +F +F Sbjct: 242 GTPCPEFMKKL-QPTVRTYVENRPKYAGYSFEKLF 275 >gi|4506095 mitogen-activated protein kinase 8 isoform JNK1 alpha1 [Homo sapiens] Length = 384 Score = 273 bits (699), Expect = 1e-73 Identities = 140/275 (50%), Positives = 191/275 (69%), Gaps = 5/275 (1%) Query: 2 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS 61 S+ FY E+ + + V +RYQNL P+GSGA G VCAA+D VA+KKLSRPFQ+ Sbjct: 4 SKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQN 63 Query: 62 IIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQK 121 HAKR YREL L+K + H+N+IGLL+VFTP +SLEEF DVY+V LM A+L +++ + Sbjct: 64 QTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ-ME 122 Query: 122 LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEM 179 L + + +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T M Sbjct: 123 LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM 182 Query: 180 TGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLV 239 T YV TR+YRAPE++L M Y + VD+WSVGCIM E++ + LFPG D+IDQ ++ + Sbjct: 183 TPYVVTRYYRAPEVILG-MGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQL 241 Query: 240 GTPGAELLKKISSESARNYIQSLTQMPKMNFANVF 274 GTP E +KK+ + R Y+++ + +F +F Sbjct: 242 GTPCPEFMKKL-QPTVRTYVENRPKYAGYSFEKLF 275 >gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens] Length = 360 Score = 268 bits (686), Expect = 3e-72 Identities = 138/284 (48%), Positives = 193/284 (67%), Gaps = 14/284 (4%) Query: 17 IWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLK 76 +++V RY NLS +G GAYG VC+A+D +RVA+KK+S PF+ + +RT RE+++L Sbjct: 18 VFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILL 76 Query: 77 HMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILR 136 +HEN+IG+ D+ A ++E+ DVY+V LM DL ++K Q L++DH+ + +YQILR Sbjct: 77 RFRHENIIGINDIIR-APTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILR 135 Query: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE------MTGYVATRWYRA 190 GLKYIHSA+++HRDLKPSNL +N C+LKI DFGLAR D + +T YVATRWYRA Sbjct: 136 GLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRA 195 Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKI 250 PEIMLN Y +++DIWSVGCI+AE+L+ R +FPG ++DQL IL ++G+P E L I Sbjct: 196 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 255 Query: 251 SSESARNYIQSLTQMPKMNFANVFIGANPLG------KLTIYPH 288 + ARNY+ SL K+ + +F A+ LT PH Sbjct: 256 INLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPH 299 >gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens] Length = 360 Score = 268 bits (686), Expect = 3e-72 Identities = 138/284 (48%), Positives = 193/284 (67%), Gaps = 14/284 (4%) Query: 17 IWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLK 76 +++V RY NLS +G GAYG VC+A+D +RVA+KK+S PF+ + +RT RE+++L Sbjct: 18 VFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILL 76 Query: 77 HMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILR 136 +HEN+IG+ D+ A ++E+ DVY+V LM DL ++K Q L++DH+ + +YQILR Sbjct: 77 RFRHENIIGINDIIR-APTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILR 135 Query: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE------MTGYVATRWYRA 190 GLKYIHSA+++HRDLKPSNL +N C+LKI DFGLAR D + +T YVATRWYRA Sbjct: 136 GLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRA 195 Query: 191 PEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKI 250 PEIMLN Y +++DIWSVGCI+AE+L+ R +FPG ++DQL IL ++G+P E L I Sbjct: 196 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 255 Query: 251 SSESARNYIQSLTQMPKMNFANVFIGANPLG------KLTIYPH 288 + ARNY+ SL K+ + +F A+ LT PH Sbjct: 256 INLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPH 299 >gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo sapiens] Length = 357 Score = 265 bits (678), Expect = 3e-71 Identities = 135/263 (51%), Positives = 184/263 (69%), Gaps = 8/263 (3%) Query: 18 WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 77 ++V RY L +G GAYG V +A+D RVA+KK+S PF+ + +RT RE+++L Sbjct: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94 Query: 78 MKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRG 137 +HENVIG+ D+ A +LE DVY+V LM DL ++K Q+L++DH+ + +YQILRG Sbjct: 95 FRHENVIGIRDILR-ASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153 Query: 138 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE------MTGYVATRWYRAP 191 LKYIHSA+++HRDLKPSNL +N C+LKI DFGLAR D E +T YVATRWYRAP Sbjct: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKIS 251 EIMLN Y +++DIWSVGCI+AE+L+ R +FPG ++DQL IL ++G+P E L I Sbjct: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273 Query: 252 SESARNYIQSLTQMPKMNFANVF 274 + ARNY+QSL K+ +A +F Sbjct: 274 NMKARNYLQSLPSKTKVAWAKLF 296 >gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo sapiens] Length = 379 Score = 265 bits (678), Expect = 3e-71 Identities = 135/263 (51%), Positives = 184/263 (69%), Gaps = 8/263 (3%) Query: 18 WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 77 ++V RY L +G GAYG V +A+D RVA+KK+S PF+ + +RT RE+++L Sbjct: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94 Query: 78 MKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRG 137 +HENVIG+ D+ A +LE DVY+V LM DL ++K Q+L++DH+ + +YQILRG Sbjct: 95 FRHENVIGIRDILR-ASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153 Query: 138 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE------MTGYVATRWYRAP 191 LKYIHSA+++HRDLKPSNL +N C+LKI DFGLAR D E +T YVATRWYRAP Sbjct: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKIS 251 EIMLN Y +++DIWSVGCI+AE+L+ R +FPG ++DQL IL ++G+P E L I Sbjct: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 273 Query: 252 SESARNYIQSLTQMPKMNFANVF 274 + ARNY+QSL K+ +A +F Sbjct: 274 NMKARNYLQSLPSKTKVAWAKLF 296 >gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo sapiens] Length = 816 Score = 260 bits (664), Expect = 1e-69 Identities = 129/269 (47%), Positives = 182/269 (67%), Gaps = 8/269 (2%) Query: 18 WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 77 ++V + Y+ + +G+GAYG V +A TG +VA+KK+ F + +AKRT REL++LKH Sbjct: 49 FDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKH 108 Query: 78 MKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIV-KCQKLTDDHVQFLIYQILR 136 KH+N+I + D+ P EF VY+V LM +DL+ I+ Q LT +HV++ +YQ+LR Sbjct: 109 FKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLR 168 Query: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE-------MTGYVATRWYR 189 GLKY+HSA +IHRDLKPSNL VNE+CELKI DFG+AR MT YVATRWYR Sbjct: 169 GLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYR 228 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKK 249 APE+ML+ Y Q +D+WSVGCI E+L R LFPG +++ QL+LI+ ++GTP +++ Sbjct: 229 APELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQA 288 Query: 250 ISSESARNYIQSLTQMPKMNFANVFIGAN 278 + +E R YIQSL + + V+ GA+ Sbjct: 289 VGAERVRAYIQSLPPRQPVPWETVYPGAD 317 >gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo sapiens] Length = 816 Score = 260 bits (664), Expect = 1e-69 Identities = 129/269 (47%), Positives = 182/269 (67%), Gaps = 8/269 (2%) Query: 18 WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 77 ++V + Y+ + +G+GAYG V +A TG +VA+KK+ F + +AKRT REL++LKH Sbjct: 49 FDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKH 108 Query: 78 MKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIV-KCQKLTDDHVQFLIYQILR 136 KH+N+I + D+ P EF VY+V LM +DL+ I+ Q LT +HV++ +YQ+LR Sbjct: 109 FKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLR 168 Query: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE-------MTGYVATRWYR 189 GLKY+HSA +IHRDLKPSNL VNE+CELKI DFG+AR MT YVATRWYR Sbjct: 169 GLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYR 228 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKK 249 APE+ML+ Y Q +D+WSVGCI E+L R LFPG +++ QL+LI+ ++GTP +++ Sbjct: 229 APELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQA 288 Query: 250 ISSESARNYIQSLTQMPKMNFANVFIGAN 278 + +E R YIQSL + + V+ GA+ Sbjct: 289 VGAERVRAYIQSLPPRQPVPWETVYPGAD 317 >gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo sapiens] Length = 816 Score = 260 bits (664), Expect = 1e-69 Identities = 129/269 (47%), Positives = 182/269 (67%), Gaps = 8/269 (2%) Query: 18 WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 77 ++V + Y+ + +G+GAYG V +A TG +VA+KK+ F + +AKRT REL++LKH Sbjct: 49 FDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKH 108 Query: 78 MKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIV-KCQKLTDDHVQFLIYQILR 136 KH+N+I + D+ P EF VY+V LM +DL+ I+ Q LT +HV++ +YQ+LR Sbjct: 109 FKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLR 168 Query: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE-------MTGYVATRWYR 189 GLKY+HSA +IHRDLKPSNL VNE+CELKI DFG+AR MT YVATRWYR Sbjct: 169 GLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYR 228 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKK 249 APE+ML+ Y Q +D+WSVGCI E+L R LFPG +++ QL+LI+ ++GTP +++ Sbjct: 229 APELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQA 288 Query: 250 ISSESARNYIQSLTQMPKMNFANVFIGAN 278 + +E R YIQSL + + V+ GA+ Sbjct: 289 VGAERVRAYIQSLPPRQPVPWETVYPGAD 317 >gi|205277412 mitogen-activated protein kinase 9 isoform JNK2 gamma [Homo sapiens] Length = 242 Score = 254 bits (648), Expect = 8e-68 Identities = 131/224 (58%), Positives = 165/224 (73%), Gaps = 4/224 (1%) Query: 8 FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67 FY ++ + + V +RYQ L P+GSGA G VCAAFDT G+ VAVKKLSRPFQ+ HAKR Sbjct: 10 FYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKR 69 Query: 68 TYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127 YREL LLK + H+N+I LL+VFTP ++LEEF DVYLV LM A+L ++ +L + + Sbjct: 70 AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH-MELDHERM 128 Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH--TDDEMTGYVAT 185 +L+YQ+L G+K++HSA IIHRDLKPSN+ V DC LKILDFGLAR T+ MT YV T Sbjct: 129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVT 188 Query: 186 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHI 229 R+YRAPE++L M Y + VDIWSVGCIM EL+ G +F GTD I Sbjct: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMGELVKGCVIFQGTDRI 231 >gi|158138507 mitogen-activated protein kinase 3 isoform 3 [Homo sapiens] Length = 335 Score = 241 bits (614), Expect = 7e-64 Identities = 121/227 (53%), Positives = 162/227 (71%), Gaps = 8/227 (3%) Query: 18 WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 77 ++V RY L +G GAYG V +A+D RVA+KK+S PF+ + +RT RE+++L Sbjct: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLR 94 Query: 78 MKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRG 137 +HENVIG+ D+ A +LE DVY+V LM DL ++K Q+L++DH+ + +YQILRG Sbjct: 95 FRHENVIGIRDILR-ASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRG 153 Query: 138 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE------MTGYVATRWYRAP 191 LKYIHSA+++HRDLKPSNL +N C+LKI DFGLAR D E +T YVATRWYRAP Sbjct: 154 LKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAP 213 Query: 192 EIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRL 238 EIMLN Y +++DIWSVGCI+AE+L+ R +FPG ++DQL IL L Sbjct: 214 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILAL 260 >gi|149408126 nemo like kinase [Homo sapiens] Length = 527 Score = 220 bits (560), Expect = 1e-57 Identities = 117/236 (49%), Positives = 159/236 (67%), Gaps = 7/236 (2%) Query: 29 PVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLD 88 P+G GA+G V + D + G RVA+KK+ FQ+++ KR +REL++L KH+NV+ LD Sbjct: 143 PIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALD 202 Query: 89 VFTPARSLEEFNDVYLVTHLMGADLNNI-VKCQKLTDDHVQFLIYQILRGLKYIHSADII 147 + P ++ F ++Y+VT LM +DL+ I V Q L+ DHV+ +YQILRGLKY+HSA I+ Sbjct: 203 ILQPPH-IDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGIL 261 Query: 148 HRDLKPSNLAVNEDCELKILDFGLARHTD-DE---MTGYVATRWYRAPEIMLNWMHYNQT 203 HRD+KP NL VN +C LKI DFGLAR + DE MT V T++YRAPEI++ HY+ Sbjct: 262 HRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNA 321 Query: 204 VDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYI 259 +DIWSVGCI AELL R LF I QL LI L+GTP E + + + E A+ +I Sbjct: 322 IDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAM-RTACEGAKAHI 376 >gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens] Length = 544 Score = 196 bits (497), Expect = 3e-50 Identities = 107/258 (41%), Positives = 151/258 (58%), Gaps = 14/258 (5%) Query: 20 VPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHM- 78 + RY +G GAYG V A D +TG VA+KK+ F+ A+RT+RE+ LL+ Sbjct: 9 IVRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFG 68 Query: 79 KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDD-HVQFLIYQILRG 137 H N+I LLDV E D+YLV M DLN +++ L D HV+ + YQ+LR Sbjct: 69 DHPNIISLLDVIRA----ENDRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRA 124 Query: 138 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT--------DDEMTGYVATRWYR 189 +++HS ++HRD KPSN+ ++ +C +K+ DFGLAR D +T YVATRWYR Sbjct: 125 TRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYR 184 Query: 190 APEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKK 249 APE++L+ Y VD+WS+GCI+ E+L GR LFPGT + QL+LIL + P E L Sbjct: 185 APEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLA 244 Query: 250 ISSESARNYIQSLTQMPK 267 + S + + L P+ Sbjct: 245 LGSGCRASVLHQLGSRPR 262 >gi|4506091 mitogen-activated protein kinase 6 [Homo sapiens] Length = 721 Score = 184 bits (468), Expect = 6e-47 Identities = 97/239 (40%), Positives = 153/239 (64%), Gaps = 21/239 (8%) Query: 18 WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKK--LSRPFQSIIHAKRTYRELRLL 75 +++ RY +L P+G G G V +A D RVA+KK L+ P QS+ HA RE++++ Sbjct: 14 FDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDP-QSVKHA---LREIKII 69 Query: 76 KHMKHENVIGLLDVFTPARS--------LEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127 + + H+N++ + ++ P+ S L E N VY+V M DL N+++ L ++H Sbjct: 70 RRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHA 129 Query: 128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLARHTD------DEMT 180 + +YQ+LRGLKYIHSA+++HRDLKP+NL +N ED LKI DFGLAR D ++ Sbjct: 130 RLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLS 189 Query: 181 GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLV 239 + T+WYR+P ++L+ +Y + +D+W+ GCI AE+LTG+TLF G ++Q++LIL + Sbjct: 190 EGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESI 248 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.323 0.138 0.416 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 11,014,299 Number of Sequences: 37866 Number of extensions: 454637 Number of successful extensions: 2814 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 731 Number of HSP's successfully gapped in prelim test: 65 Number of HSP's that attempted gapping in prelim test: 847 Number of HSP's gapped (non-prelim): 882 length of query: 297 length of database: 18,247,518 effective HSP length: 102 effective length of query: 195 effective length of database: 14,385,186 effective search space: 2805111270 effective search space used: 2805111270 T: 11 A: 40 X1: 16 ( 7.5 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (22.0 bits) S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.