Search of human proteins with 209863024

Search of human proteins with 209863024

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|209863024 transient receptor potential cation channel,
subfamily C, member 4 isoform epsilon [Homo sapiens]
         (982 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|209863024 transient receptor potential cation channel, subfam...  1964   0.0  
gi|7706747 transient receptor potential cation channel, subfamil...  1947   0.0  
gi|209863026 transient receptor potential cation channel, subfam...  1568   0.0  
gi|209863030 transient receptor potential cation channel, subfam...  1468   0.0  
gi|209863032 transient receptor potential cation channel, subfam...  1371   0.0  
gi|209863028 transient receptor potential cation channel, subfam...  1259   0.0  
gi|6912736 transient receptor potential cation channel, subfamil...  1247   0.0  
gi|4507685 transient receptor potential cation channel, subfamil...   634   0.0  
gi|9966865 transient receptor potential cation channel, subfamil...   557   e-158
gi|194733735 transient receptor potential cation channel, subfam...   536   e-152
gi|4507687 transient receptor potential cation channel, subfamil...   536   e-152
gi|5730102 transient receptor potential cation channel, subfamil...   536   e-152
gi|169216484 PREDICTED: similar to transient receptor potential ...   200   5e-51
gi|109689695 transient receptor potential cation channel, subfam...   109   1e-23
gi|4507689 transient receptor potential cation channel, subfamil...    92   3e-18
gi|94538366 transient receptor potential cation channel, subfami...    87   1e-16
gi|18921093 transient receptor potential cation channel, subfami...    84   6e-16
gi|148612863 transient receptor potential cation channel, subfam...    84   8e-16
gi|239754785 PREDICTED: similar to transient receptor potential ...    80   9e-15
gi|239749299 PREDICTED: similar to transient receptor potential ...    80   9e-15
gi|239743393 PREDICTED: hypothetical protein XP_002342847, parti...    80   9e-15
gi|239509090 PREDICTED: similar to transient receptor potential ...    80   9e-15
gi|154091312 transient receptor potential cation channel, subfam...    78   4e-14
gi|154091308 transient receptor potential cation channel, subfam...    78   4e-14
gi|154091310 transient receptor potential cation channel, subfam...    78   4e-14
gi|154091320 transient receptor potential cation channel, subfam...    78   4e-14
gi|154091318 transient receptor potential cation channel, subfam...    78   4e-14
gi|154091316 transient receptor potential cation channel, subfam...    78   4e-14
gi|154091314 transient receptor potential cation channel, subfam...    78   4e-14
gi|11225266 transient receptor potential cation channel, subfami...    65   3e-10

>gi|209863024 transient receptor potential cation channel, subfamily
           C, member 4 isoform epsilon [Homo sapiens]
          Length = 982

 Score = 1964 bits (5087), Expect = 0.0
 Identities = 982/982 (100%), Positives = 982/982 (100%)

Query: 1   MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK 60
           MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK
Sbjct: 1   MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK 60

Query: 61  ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK 120
           ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK
Sbjct: 61  ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK 120

Query: 121 PSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVE 180
           PSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVE
Sbjct: 121 PSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVE 180

Query: 181 CVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSE 240
           CVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSE
Sbjct: 181 CVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSE 240

Query: 241 YEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEF 300
           YEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEF
Sbjct: 241 YEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEF 300

Query: 301 VAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIR 360
           VAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIR
Sbjct: 301 VAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIR 360

Query: 361 KPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQ 420
           KPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQ
Sbjct: 361 KPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQ 420

Query: 421 MWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEAL 480
           MWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEAL
Sbjct: 421 MWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEAL 480

Query: 481 FAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFY 540
           FAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFY
Sbjct: 481 FAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFY 540

Query: 541 YEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATM 600
           YEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATM
Sbjct: 541 YEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATM 600

Query: 601 FGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVI 660
           FGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVI
Sbjct: 601 FGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVI 660

Query: 661 PSPKSLWYLIKWIWTHLCKKKMRRKPESFGTIGVRTQHRRAADNLRRHHQYQEVMRNLVK 720
           PSPKSLWYLIKWIWTHLCKKKMRRKPESFGTIGVRTQHRRAADNLRRHHQYQEVMRNLVK
Sbjct: 661 PSPKSLWYLIKWIWTHLCKKKMRRKPESFGTIGVRTQHRRAADNLRRHHQYQEVMRNLVK 720

Query: 721 RYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVLGLLRGSKLSTIQSANASKESSNSA 780
           RYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVLGLLRGSKLSTIQSANASKESSNSA
Sbjct: 721 RYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVLGLLRGSKLSTIQSANASKESSNSA 780

Query: 781 DSDEKSDSEGNSKDKKKNFSLFDLTTLIHPRSAAIASERHNISNGSALVVQEPPREKQRK 840
           DSDEKSDSEGNSKDKKKNFSLFDLTTLIHPRSAAIASERHNISNGSALVVQEPPREKQRK
Sbjct: 781 DSDEKSDSEGNSKDKKKNFSLFDLTTLIHPRSAAIASERHNISNGSALVVQEPPREKQRK 840

Query: 841 VNFVTDIKNFGLFHRRSKQNAAEQNANQIFSVSEEVARQQAAGPLERNIQLESRGLASRG 900
           VNFVTDIKNFGLFHRRSKQNAAEQNANQIFSVSEEVARQQAAGPLERNIQLESRGLASRG
Sbjct: 841 VNFVTDIKNFGLFHRRSKQNAAEQNANQIFSVSEEVARQQAAGPLERNIQLESRGLASRG 900

Query: 901 DLSIPGLSEQCVLVDHRERNTDTLGLQVGKRVCPFKSEKVVVEDTVPIIPKEKHAKEEDS 960
           DLSIPGLSEQCVLVDHRERNTDTLGLQVGKRVCPFKSEKVVVEDTVPIIPKEKHAKEEDS
Sbjct: 901 DLSIPGLSEQCVLVDHRERNTDTLGLQVGKRVCPFKSEKVVVEDTVPIIPKEKHAKEEDS 960

Query: 961 SIDYDLNLPDTVTHEDYVTTRL 982
           SIDYDLNLPDTVTHEDYVTTRL
Sbjct: 961 SIDYDLNLPDTVTHEDYVTTRL 982


>gi|7706747 transient receptor potential cation channel, subfamily
           C, member 4 isoform alpha [Homo sapiens]
          Length = 977

 Score = 1947 bits (5044), Expect = 0.0
 Identities = 977/982 (99%), Positives = 977/982 (99%), Gaps = 5/982 (0%)

Query: 1   MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK 60
           MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK
Sbjct: 1   MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK 60

Query: 61  ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK 120
           ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK
Sbjct: 61  ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK 120

Query: 121 PSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVE 180
           PSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVE
Sbjct: 121 PSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVE 180

Query: 181 CVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSE 240
           CVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSE
Sbjct: 181 CVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSE 240

Query: 241 YEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEF 300
           YEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEF
Sbjct: 241 YEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEF 300

Query: 301 VAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIR 360
           VAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIR
Sbjct: 301 VAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIR 360

Query: 361 KPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQ 420
           KPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQ
Sbjct: 361 KPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQ 420

Query: 421 MWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEAL 480
           MWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEAL
Sbjct: 421 MWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEAL 480

Query: 481 FAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFY 540
           FAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFY
Sbjct: 481 FAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFY 540

Query: 541 YEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATM 600
           YEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATM
Sbjct: 541 YEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATM 600

Query: 601 FGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVI 660
           FGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVI
Sbjct: 601 FGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVI 660

Query: 661 PSPKSLWYLIKWIWTHLCKKKMRRKPESFGTIGVRTQHRRAADNLRRHHQYQEVMRNLVK 720
           PSPKSLWYLIKWIWTHLCKKKMRRKPESFGTIG     RRAADNLRRHHQYQEVMRNLVK
Sbjct: 661 PSPKSLWYLIKWIWTHLCKKKMRRKPESFGTIG-----RRAADNLRRHHQYQEVMRNLVK 715

Query: 721 RYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVLGLLRGSKLSTIQSANASKESSNSA 780
           RYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVLGLLRGSKLSTIQSANASKESSNSA
Sbjct: 716 RYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVLGLLRGSKLSTIQSANASKESSNSA 775

Query: 781 DSDEKSDSEGNSKDKKKNFSLFDLTTLIHPRSAAIASERHNISNGSALVVQEPPREKQRK 840
           DSDEKSDSEGNSKDKKKNFSLFDLTTLIHPRSAAIASERHNISNGSALVVQEPPREKQRK
Sbjct: 776 DSDEKSDSEGNSKDKKKNFSLFDLTTLIHPRSAAIASERHNISNGSALVVQEPPREKQRK 835

Query: 841 VNFVTDIKNFGLFHRRSKQNAAEQNANQIFSVSEEVARQQAAGPLERNIQLESRGLASRG 900
           VNFVTDIKNFGLFHRRSKQNAAEQNANQIFSVSEEVARQQAAGPLERNIQLESRGLASRG
Sbjct: 836 VNFVTDIKNFGLFHRRSKQNAAEQNANQIFSVSEEVARQQAAGPLERNIQLESRGLASRG 895

Query: 901 DLSIPGLSEQCVLVDHRERNTDTLGLQVGKRVCPFKSEKVVVEDTVPIIPKEKHAKEEDS 960
           DLSIPGLSEQCVLVDHRERNTDTLGLQVGKRVCPFKSEKVVVEDTVPIIPKEKHAKEEDS
Sbjct: 896 DLSIPGLSEQCVLVDHRERNTDTLGLQVGKRVCPFKSEKVVVEDTVPIIPKEKHAKEEDS 955

Query: 961 SIDYDLNLPDTVTHEDYVTTRL 982
           SIDYDLNLPDTVTHEDYVTTRL
Sbjct: 956 SIDYDLNLPDTVTHEDYVTTRL 977


>gi|209863026 transient receptor potential cation channel, subfamily
           C, member 4 isoform beta [Homo sapiens]
          Length = 893

 Score = 1568 bits (4061), Expect = 0.0
 Identities = 784/789 (99%), Positives = 784/789 (99%), Gaps = 5/789 (0%)

Query: 1   MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK 60
           MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK
Sbjct: 1   MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK 60

Query: 61  ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK 120
           ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK
Sbjct: 61  ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK 120

Query: 121 PSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVE 180
           PSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVE
Sbjct: 121 PSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVE 180

Query: 181 CVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSE 240
           CVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSE
Sbjct: 181 CVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSE 240

Query: 241 YEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEF 300
           YEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEF
Sbjct: 241 YEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEF 300

Query: 301 VAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIR 360
           VAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIR
Sbjct: 301 VAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIR 360

Query: 361 KPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQ 420
           KPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQ
Sbjct: 361 KPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQ 420

Query: 421 MWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEAL 480
           MWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEAL
Sbjct: 421 MWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEAL 480

Query: 481 FAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFY 540
           FAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFY
Sbjct: 481 FAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFY 540

Query: 541 YEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATM 600
           YEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATM
Sbjct: 541 YEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATM 600

Query: 601 FGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVI 660
           FGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVI
Sbjct: 601 FGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVI 660

Query: 661 PSPKSLWYLIKWIWTHLCKKKMRRKPESFGTIGVRTQHRRAADNLRRHHQYQEVMRNLVK 720
           PSPKSLWYLIKWIWTHLCKKKMRRKPESFGTIG     RRAADNLRRHHQYQEVMRNLVK
Sbjct: 661 PSPKSLWYLIKWIWTHLCKKKMRRKPESFGTIG-----RRAADNLRRHHQYQEVMRNLVK 715

Query: 721 RYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVLGLLRGSKLSTIQSANASKESSNSA 780
           RYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVLGLLRGSKLSTIQSANASKESSNSA
Sbjct: 716 RYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVLGLLRGSKLSTIQSANASKESSNSA 775

Query: 781 DSDEKSDSE 789
           DSDEKSDSE
Sbjct: 776 DSDEKSDSE 784



 Score =  222 bits (566), Expect = 1e-57
 Identities = 111/126 (88%), Positives = 118/126 (93%)

Query: 857 SKQNAAEQNANQIFSVSEEVARQQAAGPLERNIQLESRGLASRGDLSIPGLSEQCVLVDH 916
           SK+++   ++++     EEVARQQAAGPLERNIQLESRGLASRGDLSIPGLSEQCVLVDH
Sbjct: 768 SKESSNSADSDEKSDSEEEVARQQAAGPLERNIQLESRGLASRGDLSIPGLSEQCVLVDH 827

Query: 917 RERNTDTLGLQVGKRVCPFKSEKVVVEDTVPIIPKEKHAKEEDSSIDYDLNLPDTVTHED 976
           RERNTDTLGLQVGKRVCPFKSEKVVVEDTVPIIPKEKHAKEEDSSIDYDLNLPDTVTHED
Sbjct: 828 RERNTDTLGLQVGKRVCPFKSEKVVVEDTVPIIPKEKHAKEEDSSIDYDLNLPDTVTHED 887

Query: 977 YVTTRL 982
           YVTTRL
Sbjct: 888 YVTTRL 893


>gi|209863030 transient receptor potential cation channel, subfamily
           C, member 4 isoform delta [Homo sapiens]
          Length = 836

 Score = 1468 bits (3801), Expect = 0.0
 Identities = 736/765 (96%), Positives = 742/765 (96%), Gaps = 8/765 (1%)

Query: 1   MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK 60
           MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK
Sbjct: 1   MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK 60

Query: 61  ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK 120
           ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK
Sbjct: 61  ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK 120

Query: 121 PSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVE 180
           PSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVE
Sbjct: 121 PSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVE 180

Query: 181 CVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSE 240
           CVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSE
Sbjct: 181 CVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSE 240

Query: 241 YEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEF 300
           YEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEF
Sbjct: 241 YEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEF 300

Query: 301 VAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIR 360
           VAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIR
Sbjct: 301 VAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIR 360

Query: 361 KPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQ 420
           KPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQ
Sbjct: 361 KPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQ 420

Query: 421 MWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEAL 480
           MWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEAL
Sbjct: 421 MWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEAL 480

Query: 481 FAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFY 540
           FAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFY
Sbjct: 481 FAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFY 540

Query: 541 YEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATM 600
           YEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATM
Sbjct: 541 YEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATM 600

Query: 601 FGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVI 660
           FGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVI
Sbjct: 601 FGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVI 660

Query: 661 PSPKSLWYLIKWIWTHLCKKKMRRKPESFGTIGVRTQHRRAADNLRRHHQYQEVMRNLVK 720
           PSPKSLWYLIKWIWTHLCKKKMRRKPESFGTIG     RRAADNLRRHHQYQEVMRNLVK
Sbjct: 661 PSPKSLWYLIKWIWTHLCKKKMRRKPESFGTIG-----RRAADNLRRHHQYQEVMRNLVK 715

Query: 721 RYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVLGLLRGSKLS 765
           RYVAAMIRDAKTEE   ++    L+++I   + E  GL     LS
Sbjct: 716 RYVAAMIRDAKTEEVARQQAAGPLERNI---QLESRGLASRGDLS 757



 Score =  219 bits (559), Expect = 8e-57
 Identities = 109/110 (99%), Positives = 110/110 (100%)

Query: 873 SEEVARQQAAGPLERNIQLESRGLASRGDLSIPGLSEQCVLVDHRERNTDTLGLQVGKRV 932
           +EEVARQQAAGPLERNIQLESRGLASRGDLSIPGLSEQCVLVDHRERNTDTLGLQVGKRV
Sbjct: 727 TEEVARQQAAGPLERNIQLESRGLASRGDLSIPGLSEQCVLVDHRERNTDTLGLQVGKRV 786

Query: 933 CPFKSEKVVVEDTVPIIPKEKHAKEEDSSIDYDLNLPDTVTHEDYVTTRL 982
           CPFKSEKVVVEDTVPIIPKEKHAKEEDSSIDYDLNLPDTVTHEDYVTTRL
Sbjct: 787 CPFKSEKVVVEDTVPIIPKEKHAKEEDSSIDYDLNLPDTVTHEDYVTTRL 836


>gi|209863032 transient receptor potential cation channel, subfamily
           C, member 4 isoform zeta [Homo sapiens]
          Length = 804

 Score = 1371 bits (3548), Expect = 0.0
 Identities = 679/686 (98%), Positives = 681/686 (99%), Gaps = 5/686 (0%)

Query: 297 QKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLG 356
           +K+FVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLG
Sbjct: 124 EKQFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLG 183

Query: 357 LFIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWG 416
           LFIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWG
Sbjct: 184 LFIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWG 243

Query: 417 EIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLV 476
           EIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLV
Sbjct: 244 EIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLV 303

Query: 477 AEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQ 536
           AEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQ
Sbjct: 304 AEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQ 363

Query: 537 LYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFV 596
           LYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFV
Sbjct: 364 LYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFV 423

Query: 597 GATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTP 656
           GATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTP
Sbjct: 424 GATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTP 483

Query: 657 FNVIPSPKSLWYLIKWIWTHLCKKKMRRKPESFGTIGVRTQHRRAADNLRRHHQYQEVMR 716
           FNVIPSPKSLWYLIKWIWTHLCKKKMRRKPESFGTIG     RRAADNLRRHHQYQEVMR
Sbjct: 484 FNVIPSPKSLWYLIKWIWTHLCKKKMRRKPESFGTIG-----RRAADNLRRHHQYQEVMR 538

Query: 717 NLVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVLGLLRGSKLSTIQSANASKES 776
           NLVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVLGLLRGSKLSTIQSANASKES
Sbjct: 539 NLVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVLGLLRGSKLSTIQSANASKES 598

Query: 777 SNSADSDEKSDSEGNSKDKKKNFSLFDLTTLIHPRSAAIASERHNISNGSALVVQEPPRE 836
           SNSADSDEKSDSEGNSKDKKKNFSLFDLTTLIHPRSAAIASERHNISNGSALVVQEPPRE
Sbjct: 599 SNSADSDEKSDSEGNSKDKKKNFSLFDLTTLIHPRSAAIASERHNISNGSALVVQEPPRE 658

Query: 837 KQRKVNFVTDIKNFGLFHRRSKQNAAEQNANQIFSVSEEVARQQAAGPLERNIQLESRGL 896
           KQRKVNFVTDIKNFGLFHRRSKQNAAEQNANQIFSVSEEVARQQAAGPLERNIQLESRGL
Sbjct: 659 KQRKVNFVTDIKNFGLFHRRSKQNAAEQNANQIFSVSEEVARQQAAGPLERNIQLESRGL 718

Query: 897 ASRGDLSIPGLSEQCVLVDHRERNTDTLGLQVGKRVCPFKSEKVVVEDTVPIIPKEKHAK 956
           ASRGDLSIPGLSEQCVLVDHRERNTDTLGLQVGKRVCPFKSEKVVVEDTVPIIPKEKHAK
Sbjct: 719 ASRGDLSIPGLSEQCVLVDHRERNTDTLGLQVGKRVCPFKSEKVVVEDTVPIIPKEKHAK 778

Query: 957 EEDSSIDYDLNLPDTVTHEDYVTTRL 982
           EEDSSIDYDLNLPDTVTHEDYVTTRL
Sbjct: 779 EEDSSIDYDLNLPDTVTHEDYVTTRL 804



 Score =  247 bits (630), Expect = 4e-65
 Identities = 126/126 (100%), Positives = 126/126 (100%)

Query: 1   MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK 60
           MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK
Sbjct: 1   MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK 60

Query: 61  ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK 120
           ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK
Sbjct: 61  ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK 120

Query: 121 PSGEKQ 126
           PSGEKQ
Sbjct: 121 PSGEKQ 126


>gi|209863028 transient receptor potential cation channel, subfamily
           C, member 4 isoform gamma [Homo sapiens]
          Length = 828

 Score = 1259 bits (3259), Expect = 0.0
 Identities = 629/631 (99%), Positives = 629/631 (99%)

Query: 1   MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK 60
           MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK
Sbjct: 1   MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK 60

Query: 61  ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK 120
           ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK
Sbjct: 61  ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK 120

Query: 121 PSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVE 180
           PSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVE
Sbjct: 121 PSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVE 180

Query: 181 CVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSE 240
           CVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSE
Sbjct: 181 CVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSE 240

Query: 241 YEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEF 300
           YEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEF
Sbjct: 241 YEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEF 300

Query: 301 VAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIR 360
           VAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIR
Sbjct: 301 VAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIR 360

Query: 361 KPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQ 420
           KPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQ
Sbjct: 361 KPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQ 420

Query: 421 MWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEAL 480
           MWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEAL
Sbjct: 421 MWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEAL 480

Query: 481 FAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFY 540
           FAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFY
Sbjct: 481 FAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFY 540

Query: 541 YEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATM 600
           YEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATM
Sbjct: 541 YEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATM 600

Query: 601 FGTYNVISLVVLLNMLIAMMNNSYQLIADHA 631
           FGTYNVISLVVLLNMLIAMMNNSYQLIA  A
Sbjct: 601 FGTYNVISLVVLLNMLIAMMNNSYQLIARRA 631



 Score =  222 bits (566), Expect = 1e-57
 Identities = 111/126 (88%), Positives = 118/126 (93%)

Query: 857 SKQNAAEQNANQIFSVSEEVARQQAAGPLERNIQLESRGLASRGDLSIPGLSEQCVLVDH 916
           SK+++   ++++     EEVARQQAAGPLERNIQLESRGLASRGDLSIPGLSEQCVLVDH
Sbjct: 703 SKESSNSADSDEKSDSEEEVARQQAAGPLERNIQLESRGLASRGDLSIPGLSEQCVLVDH 762

Query: 917 RERNTDTLGLQVGKRVCPFKSEKVVVEDTVPIIPKEKHAKEEDSSIDYDLNLPDTVTHED 976
           RERNTDTLGLQVGKRVCPFKSEKVVVEDTVPIIPKEKHAKEEDSSIDYDLNLPDTVTHED
Sbjct: 763 RERNTDTLGLQVGKRVCPFKSEKVVVEDTVPIIPKEKHAKEEDSSIDYDLNLPDTVTHED 822

Query: 977 YVTTRL 982
           YVTTRL
Sbjct: 823 YVTTRL 828



 Score =  176 bits (447), Expect = 7e-44
 Identities = 91/91 (100%), Positives = 91/91 (100%)

Query: 699 RRAADNLRRHHQYQEVMRNLVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVLGL 758
           RRAADNLRRHHQYQEVMRNLVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVLGL
Sbjct: 629 RRAADNLRRHHQYQEVMRNLVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVLGL 688

Query: 759 LRGSKLSTIQSANASKESSNSADSDEKSDSE 789
           LRGSKLSTIQSANASKESSNSADSDEKSDSE
Sbjct: 689 LRGSKLSTIQSANASKESSNSADSDEKSDSE 719


>gi|6912736 transient receptor potential cation channel, subfamily
           C, member 5 [Homo sapiens]
          Length = 973

 Score = 1247 bits (3226), Expect = 0.0
 Identities = 639/920 (69%), Positives = 749/920 (81%), Gaps = 28/920 (3%)

Query: 1   MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK 60
           MAQ YYK+   +PYRDRIPL+IVRAE+ELS  EKA+LNAVEKGDYA+VK++L+EAEIY+ 
Sbjct: 1   MAQLYYKKVNYSPYRDRIPLQIVRAETELSAEEKAFLNAVEKGDYATVKQALQEAEIYYN 60

Query: 61  ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK 120
           +NINC+DPLGR+ALLIAIENENLE++ELLL+ +VYVGDALL+AIRKEVVGAVELLL++++
Sbjct: 61  VNINCMDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSYRR 120

Query: 121 PSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVE 180
           PSGEKQVP +++D QFSEFTPDITPI+LAAHTNNYEIIKLLVQK V++PRPH++RCNCVE
Sbjct: 121 PSGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVE 180

Query: 181 CVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSE 240
           CVSSS+VDSLRHSRSRLNIYKALASPSLIALSSEDP LTAF+L WEL+ELSKVENEFK+E
Sbjct: 181 CVSSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSKVENEFKAE 240

Query: 241 YEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSL-IEEQSGNDLARLKLAIKYRQKE 299
           YEELS+QCK FAKDLLDQ RSSRELEIILN+RDD+S  ++ Q  +DLA+LK+AIKY QKE
Sbjct: 241 YEELSQQCKLFAKDLLDQARSSRELEIILNHRDDHSEELDPQKYHDLAKLKVAIKYHQKE 300

Query: 300 FVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFI 359
           FVAQPNCQQLLA+ WYD FPGWRR+HW VK++TC  IG LFP+ S+ YLI+P+S LGLFI
Sbjct: 301 FVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFI 360

Query: 360 RKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIK 419
           +KPFIKFICHTASYLTFLF+LLLASQHI R+DL+ QGPPPT+VEWMILPWVLGFIWGEIK
Sbjct: 361 KKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIK 420

Query: 420 QMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEA 479
           +MWDGG  +YIHDWWNLMDF MNSLYLATISLKIVA+VKY+   PRE W+MWHPTL+AEA
Sbjct: 421 EMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEA 480

Query: 480 LFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYF 539
           LFAI+NI SSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYF
Sbjct: 481 LFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYF 540

Query: 540 YYEETKGL----TCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEF 595
           YY ET+ +     CKGIRCEKQNNAFSTLFETLQSLFWS+FGL+NLYVTNVKA+HEFTEF
Sbjct: 541 YY-ETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEF 599

Query: 596 VGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPT 655
           VGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYF+EGGTLP 
Sbjct: 600 VGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPP 659

Query: 656 PFNVIPSPKSLWYLIKWIWTHLCKKK---MRRKPESFGTIGVRTQHRRAADNLRRHHQYQ 712
           PFN+IPSPKS  YL  W     C K+    RR+  +     +R+   R AD+L ++  YQ
Sbjct: 660 PFNIIPSPKSFLYLGNWFNNTFCPKRDPDGRRRRRN-----LRSFTERNADSLIQNQHYQ 714

Query: 713 EVMRNLVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVLGLLRGSKLSTIQSANA 772
           EV+RNLVKRYVAAMIR++KT EGLTEENFKELKQDISSFR+EVL LL   K       + 
Sbjct: 715 EVIRNLVKRYVAAMIRNSKTHEGLTEENFKELKQDISSFRYEVLDLLGNRK----HPRSF 770

Query: 773 SKESSNSADSDEKSDSEGNSKDKKK--NFSLFDLTTLIHPRSAAIASERHNISNGSALVV 830
           S  S+  +  D+ +D  G ++ K K  +F+L       H         R + + G +   
Sbjct: 771 STSSTELSQRDDNNDGSGGARAKSKSVSFNLGCKKKTCHGPPLIRTMPRSSGAQGKS--- 827

Query: 831 QEPPREKQRKVNFV-TDIKNFGLFHRRSKQNAAEQNANQIFSVSEEVARQQAAGPLERNI 889
                E   K +F+   +K  GL   +   + +E ++  ++++S+ + +Q       R  
Sbjct: 828 ---KAESSSKRSFMGPSLKKLGLLFSKFNGHMSEPSSEPMYTISDGIVQQHCMWQDIRYS 884

Query: 890 QLESRGLASRGDLSIPGLSE 909
           Q+E +G A     S   LSE
Sbjct: 885 QME-KGKAEACSQSEINLSE 903


>gi|4507685 transient receptor potential cation channel, subfamily
           C, member 1 [Homo sapiens]
          Length = 759

 Score =  634 bits (1634), Expect = 0.0
 Identities = 354/768 (46%), Positives = 489/768 (63%), Gaps = 61/768 (7%)

Query: 20  LRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIE 79
           +R V+ E+ L+  EK +L A +KGDY  VKK LEE      +NINC+D LGR A+ I IE
Sbjct: 37  VREVKEENTLN--EKLFLLACDKGDYYMVKKILEENSSG-DLNINCVDVLGRNAVTITIE 93

Query: 80  NENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSEF 139
           NENL++++LLL +                 G  +L+   + P             ++S  
Sbjct: 94  NENLDILQLLLDY-----------------GCQKLMERIQNP-------------EYST- 122

Query: 140 TPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRHSRSRLNI 199
           T D+ P+ILAAH NNYEI+ +L+++ VS+P+PH V C C  C + +  DSLRHSR RL+I
Sbjct: 123 TMDVAPVILAAHRNNYEILTMLLKQDVSLPKPHAVGCECTLCSAKNKKDSLRHSRFRLDI 182

Query: 200 YKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFAKDLLDQT 259
           Y+ LASP+LI L+ EDP L AF+LS +L+ELS VE EF+++YEEL+RQCK FAKDLL Q 
Sbjct: 183 YRCLASPALIMLTEEDPILRAFELSADLKELSLVEVEFRNDYEELARQCKMFAKDLLAQA 242

Query: 260 RSSRELEIILNYR------DDNSLIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLLASR 313
           R+SRELE+ILN+       D   L+EE+   +L+RLKLAIKY QKEFV+Q NCQQ L + 
Sbjct: 243 RNSRELEVILNHTSSDEPLDKRGLLEERM--NLSRLKLAIKYNQKEFVSQSNCQQFLNTV 300

Query: 314 WYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHTASY 373
           W+ +  G+RR+    K++T   +G+ +PV S+CYLIAPKS  G  I  PF+KFI H ASY
Sbjct: 301 WFGQMSGYRRKPTCKKIMTVLTVGIFWPVLSLCYLIAPKSQFGRIIHTPFMKFIIHGASY 360

Query: 374 LTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQMWDGGLQDYIHDW 433
            TFL LL L S   +    N  GP    ++++++ W++G IW +IK++W  GL+D++ + 
Sbjct: 361 FTFLLLLNLYSLVYNEDKKNTMGPALERIDYLLILWIIGMIWSDIKRLWYEGLEDFLEES 420

Query: 434 WNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLI 493
            N + FVMNSLYLAT +LK+VA  K+     R+ WD +HPTLVAE LFA AN+ S LRL 
Sbjct: 421 RNQLSFVMNSLYLATFALKVVAHNKFHDFADRKDWDAFHPTLVAEGLFAFANVLSYLRLF 480

Query: 494 SLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFY-YEETKGLTCKGI 552
            ++T +S LGPLQIS+G+ML D  KFL ++ LVL +F  GL QLY   Y   +   C GI
Sbjct: 481 FMYTTSSILGPLQISMGQMLQDFGKFLGMFLLVLFSFTIGLTQLYDKGYTSKEQKDCVGI 540

Query: 553 RCEKQ-NNAFSTLFETLQSLFWSIFGL--INLYVTNVKAQHEFTEFVGATMFGTYNVISL 609
            CE+Q N+ F +   T  +LFW IF L  + ++VT      E   FVGA + GTYNV+ +
Sbjct: 541 FCEQQSNDTFHSFIGTCFALFWYIFSLAHVAIFVTRFSYGEELQSFVGAVIVGTYNVVVV 600

Query: 610 VVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYL 669
           +VL  +L+AM++ S+QLIA+H D EWKFAR KLW+SYF++  TLP PFN+IPSPK++ Y+
Sbjct: 601 IVLTKLLVAMLHKSFQLIANHEDKEWKFARAKLWLSYFDDKCTLPPPFNIIPSPKTICYM 660

Query: 670 I----KWIWTHLCKKKMRRKPESFGTIGVRTQHRRAADNLRRHHQYQEVMRNLVKRYVAA 725
           I    KWI +H  K K++R+        ++          +R   YQ+VM  LV RY+ +
Sbjct: 661 ISSLSKWICSHTSKGKVKRQNSLKEWRNLKQ---------KRDENYQKVMCCLVHRYLTS 711

Query: 726 MIRDAKTEEGLTEENFKELKQDISSFRFEVLGLL--RGSKLSTIQSAN 771
           M +  ++ +  T EN  EL+QD+S FR E+  LL  R SK +     N
Sbjct: 712 MRQKMQSTDQATVENLNELRQDLSKFRNEIRDLLGFRTSKYAMFYPRN 759


>gi|9966865 transient receptor potential cation channel, subfamily
           C, member 7 [Homo sapiens]
          Length = 862

 Score =  557 bits (1435), Expect = e-158
 Identities = 326/804 (40%), Positives = 465/804 (57%), Gaps = 91/804 (11%)

Query: 27  SELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELI 86
           + L+P E+ +L++ E G+   V+K LEE++    +N NC+D +G+ AL +A+ NE+LE+ 
Sbjct: 38  TSLTPEEERFLDSAEYGNIPVVRKMLEESKT---LNFNCVDYMGQNALQLAVGNEHLEVT 94

Query: 87  ELLLSFN--VYVGDALLHAIRKEVVGAVELLLNHKK-PSGEK-QVPPI----------LL 132
           ELLL       VGDALL AI K  V  VE +LNH     G++  + P+            
Sbjct: 95  ELLLKKENLARVGDALLLAISKGYVRIVEAILNHPAFAQGQRLTLSPLEQELRDDDFYAY 154

Query: 133 DKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRH 192
           D+  + F+ DITPIILAAH   YEI+ +L+ KG  + RPH+  C C EC      DS  H
Sbjct: 155 DEDGTRFSHDITPIILAAHCQEYEIVHILLLKGARIERPHDYFCKCNECTEKQRKDSFSH 214

Query: 193 SRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFA 252
           SRSR+N YK LAS + ++LSSEDP LTA +LS EL  L+ +E EFK++Y +LS QCK F 
Sbjct: 215 SRSRMNAYKGLASAAYLSLSSEDPVLTALELSNELARLANIETEFKNDYRKLSMQCKDFV 274

Query: 253 KDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLLAS 312
             +LD  R + E+E ILN   +  +  +     L+R+KLAIKY  K+FVA PNCQQ L +
Sbjct: 275 VGVLDLCRDTEEVEAILNGDVNFQVWSDHHRPSLSRIKLAIKYEVKKFVAHPNCQQQLLT 334

Query: 313 RWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHTAS 372
            WY+   G R++  AVK +  F + +  P  ++ Y IAP S LG  +R PF+KF+ H  S
Sbjct: 335 MWYENLSGLRQQSIAVKFLAVFGVSIGLPFLAIAYWIAPCSKLGRTLRSPFMKFVAHAVS 394

Query: 373 YLTFLFLLLLASQHIDRSDLNRQGPPPTI-----------------VEWMILPWVLGFIW 415
           +  FL LL++ +   DR +  +  P  T                   E +I+ WVLG IW
Sbjct: 395 FTIFLGLLVVNAS--DRFEGVKTLPNETFTDYPKQIFRVKTTQFSWTEMLIMKWVLGMIW 452

Query: 416 GEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYS--------------- 460
            E K++W+ G ++Y+   WNL+DF M S+++A+ + + +AF+K +               
Sbjct: 453 SECKEIWEEGPREYVLHLWNLLDFGMLSIFVASFTARFMAFLKATEAQLYVDQHVQDDTL 512

Query: 461 ---ALNP--------RESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISL 509
              +L P        R+ W    P +++E L+AIA + S  R+  +  AN   GPLQISL
Sbjct: 513 HNVSLPPEVAYFTYARDKWWPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISL 572

Query: 510 GRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQ 569
           GR + DI KF+ I+ +V +AF  G+  LY YY           R  K N AF+T+ E+ +
Sbjct: 573 GRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYY-----------RGAKYNPAFTTVEESFK 621

Query: 570 SLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIAD 629
           +LFWSIFGL  +    +K  H+F E +G  ++G YNV  +VVLLNMLIAM+NNSYQ I +
Sbjct: 622 TLFWSIFGLSEVISVVLKYDHKFIENIGYVLYGVYNVTMVVVLLNMLIAMINNSYQEIEE 681

Query: 630 HADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYL---IKWIWTHLCKKKMR--- 683
            AD+EWKFAR KLW+SYF+EG TLP PFN++PSPKS +YL   IK     LCK K +   
Sbjct: 682 DADVEWKFARAKLWLSYFDEGRTLPAPFNLVPSPKSFYYLIMRIKMCLIKLCKSKAKSCE 741

Query: 684 ----------RKPESFGTIGVRTQHRRAADN-LRRHHQYQEVMRNLVKRYVAAMIRDAKT 732
                     +  ++    G+R      A+N L +  +YQ++M+ L+KRYV     D + 
Sbjct: 742 NDLEMGMLNSKFKKTRYQAGMRNSENLTANNTLSKPTRYQKIMKRLIKRYVLKAQVDREN 801

Query: 733 EEGLTEENFKELKQDISSFRFEVL 756
           +E + E   KE+KQDISS R+E+L
Sbjct: 802 DE-VNEGELKEIKQDISSLRYELL 824


>gi|194733735 transient receptor potential cation channel, subfamily
           C, member 3 isoform a [Homo sapiens]
          Length = 921

 Score =  536 bits (1382), Expect = e-152
 Identities = 316/801 (39%), Positives = 462/801 (57%), Gaps = 86/801 (10%)

Query: 27  SELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELI 86
           + L+  E+ +L+A E G+   V+K LEE++    +N+NC+D +G+ AL +A+ NE+LE+ 
Sbjct: 107 TSLTAEEERFLDAAEYGNIPVVRKMLEESKT---LNVNCVDYMGQNALQLAVGNEHLEVT 163

Query: 87  ELLLSFN--VYVGDALLHAIRKEVVGAVELLLNHKKPSGEKQVPP------------ILL 132
           ELLL       +GDALL AI K  V  VE +LNH   +  K++                 
Sbjct: 164 ELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAY 223

Query: 133 DKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRH 192
           D+  + F+PDITPIILAAH   YE++ +L+ KG  + RPH+  C C +C+     DS  H
Sbjct: 224 DEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSH 283

Query: 193 SRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFA 252
           SRSR+N YK LASP+ ++LSSEDP LTA +LS EL +L+ +E EFK++Y +LS QCK F 
Sbjct: 284 SRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFV 343

Query: 253 KDLLDQTRSSRELEIILN--YRDDNSLIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLL 310
             +LD  R S E+E ILN        L   +    L+R+KLAIKY  K+FVA PNCQQ L
Sbjct: 344 VGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKLAIKYEVKKFVAHPNCQQQL 403

Query: 311 ASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHT 370
            + WY+   G R +  A+K +   ++ L  P  ++ Y IAP S LG  +R PF+KF+ H 
Sbjct: 404 LTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHA 463

Query: 371 ASYLTFLFLLLLASQ----------HIDRSDLNRQ-----GPPPTIVEWMILPWVLGFIW 415
           AS++ FL LL+  +           +I  +D  +Q         T  E +I+ WVLG +W
Sbjct: 464 ASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTTQFTWTEMLIMVWVLGMMW 523

Query: 416 GEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYS--------------- 460
            E K++W  G ++YI   WN++DF M S+++A  + + +AF++ +               
Sbjct: 524 SECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDL 583

Query: 461 ---ALNP--------RESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISL 509
               L P        R+ W    P +++E L+AIA + S  R+  +  AN   GPLQISL
Sbjct: 584 SEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISL 643

Query: 510 GRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQ 569
           GR + DI KF+ ++ +V  AF  G+  LY YY              K N AF+T+ E+ +
Sbjct: 644 GRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGA-----------KVNAAFTTVEESFK 692

Query: 570 SLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIAD 629
           +LFWSIFGL  +    +K  H+F E +G  ++G YNV  +VVLLNMLIAM+N+SYQ I D
Sbjct: 693 TLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIED 752

Query: 630 HADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTH-LCKKKMRRKPES 688
            +D+EWKFAR+KLW+SYF++G TLP PF+++PSPKS  Y I  I     C+++  +K   
Sbjct: 753 DSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIVNFPKCRRRRLQKDIE 812

Query: 689 FG------TIGVRTQ-HRRAADN------LRRHHQYQEVMRNLVKRYVAAMIRDAKTEEG 735
            G       + + TQ + R  ++      L +  +YQ++M+ L+KRYV     D + +E 
Sbjct: 813 MGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQVDKENDE- 871

Query: 736 LTEENFKELKQDISSFRFEVL 756
           + E   KE+KQDISS R+E+L
Sbjct: 872 VNEGELKEIKQDISSLRYELL 892


>gi|4507687 transient receptor potential cation channel, subfamily
           C, member 3 isoform b [Homo sapiens]
          Length = 848

 Score =  536 bits (1382), Expect = e-152
 Identities = 316/801 (39%), Positives = 462/801 (57%), Gaps = 86/801 (10%)

Query: 27  SELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELI 86
           + L+  E+ +L+A E G+   V+K LEE++    +N+NC+D +G+ AL +A+ NE+LE+ 
Sbjct: 34  TSLTAEEERFLDAAEYGNIPVVRKMLEESKT---LNVNCVDYMGQNALQLAVGNEHLEVT 90

Query: 87  ELLLSFN--VYVGDALLHAIRKEVVGAVELLLNHKKPSGEKQVPP------------ILL 132
           ELLL       +GDALL AI K  V  VE +LNH   +  K++                 
Sbjct: 91  ELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAY 150

Query: 133 DKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRH 192
           D+  + F+PDITPIILAAH   YE++ +L+ KG  + RPH+  C C +C+     DS  H
Sbjct: 151 DEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSH 210

Query: 193 SRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFA 252
           SRSR+N YK LASP+ ++LSSEDP LTA +LS EL +L+ +E EFK++Y +LS QCK F 
Sbjct: 211 SRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFV 270

Query: 253 KDLLDQTRSSRELEIILN--YRDDNSLIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLL 310
             +LD  R S E+E ILN        L   +    L+R+KLAIKY  K+FVA PNCQQ L
Sbjct: 271 VGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKLAIKYEVKKFVAHPNCQQQL 330

Query: 311 ASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHT 370
            + WY+   G R +  A+K +   ++ L  P  ++ Y IAP S LG  +R PF+KF+ H 
Sbjct: 331 LTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHA 390

Query: 371 ASYLTFLFLLLLASQ----------HIDRSDLNRQ-----GPPPTIVEWMILPWVLGFIW 415
           AS++ FL LL+  +           +I  +D  +Q         T  E +I+ WVLG +W
Sbjct: 391 ASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTTQFTWTEMLIMVWVLGMMW 450

Query: 416 GEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYS--------------- 460
            E K++W  G ++YI   WN++DF M S+++A  + + +AF++ +               
Sbjct: 451 SECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDL 510

Query: 461 ---ALNP--------RESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISL 509
               L P        R+ W    P +++E L+AIA + S  R+  +  AN   GPLQISL
Sbjct: 511 SEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISL 570

Query: 510 GRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQ 569
           GR + DI KF+ ++ +V  AF  G+  LY YY              K N AF+T+ E+ +
Sbjct: 571 GRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGA-----------KVNAAFTTVEESFK 619

Query: 570 SLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIAD 629
           +LFWSIFGL  +    +K  H+F E +G  ++G YNV  +VVLLNMLIAM+N+SYQ I D
Sbjct: 620 TLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIED 679

Query: 630 HADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTH-LCKKKMRRKPES 688
            +D+EWKFAR+KLW+SYF++G TLP PF+++PSPKS  Y I  I     C+++  +K   
Sbjct: 680 DSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIVNFPKCRRRRLQKDIE 739

Query: 689 FG------TIGVRTQ-HRRAADN------LRRHHQYQEVMRNLVKRYVAAMIRDAKTEEG 735
            G       + + TQ + R  ++      L +  +YQ++M+ L+KRYV     D + +E 
Sbjct: 740 MGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQVDKENDE- 798

Query: 736 LTEENFKELKQDISSFRFEVL 756
           + E   KE+KQDISS R+E+L
Sbjct: 799 VNEGELKEIKQDISSLRYELL 819


>gi|5730102 transient receptor potential cation channel, subfamily
           C, member 6 [Homo sapiens]
          Length = 931

 Score =  536 bits (1380), Expect = e-152
 Identities = 321/827 (38%), Positives = 461/827 (55%), Gaps = 117/827 (14%)

Query: 27  SELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELI 86
           + LS  E+ +L+A E G+   V+K LEE      +N+NC+D +G+ AL +A+ NE+LE+ 
Sbjct: 93  TSLSIEEERFLDAAEYGNIPVVRKMLEECH---SLNVNCVDYMGQNALQLAVANEHLEIT 149

Query: 87  ELLLSFNVY--VGDALLHAIRKEVVGAVELLLNHKKPSGEKQVPP------------ILL 132
           ELLL       VGDALL AI K  V  VE +L+H   +  K++                 
Sbjct: 150 ELLLKKENLSRVGDALLLAISKGYVRIVEAILSHPAFAEGKRLATSPSQSELQQDDFYAY 209

Query: 133 DKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRH 192
           D+  + F+ D+TPIILAAH   YEI+  L++KG  + RPH+  C C +C      DS  H
Sbjct: 210 DEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCKCNDCNQKQKHDSFSH 269

Query: 193 SRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFA 252
           SRSR+N YK LASP+ ++LSSEDP +TA +LS EL  L+ +E EFK++Y++LS QCK F 
Sbjct: 270 SRSRINAYKGLASPAYLSLSSEDPVMTALELSNELAVLANIEKEFKNDYKKLSMQCKDFV 329

Query: 253 KDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLLAS 312
             LLD  R++ E+E ILN   +     +    +L+RLKLAIKY  K+FVA PNCQQ L S
Sbjct: 330 VGLLDLCRNTEEVEAILNGDVETLQSGDHGRPNLSRLKLAIKYEVKKFVAHPNCQQQLLS 389

Query: 313 RWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHTAS 372
            WY+   G R++  AVK +    + +  P  ++ Y  AP S +G  +R PF+KF+ H AS
Sbjct: 390 IWYENLSGLRQQTMAVKFLVVLAVAIGLPFLALIYWFAPCSKMGKIMRGPFMKFVAHAAS 449

Query: 373 YLTFLFLLLLASQHIDRSDLNRQGPPPTIVE--------------WM---ILPWVLGFIW 415
           +  FL LL++ +   DR +  +  P  T  +              WM   I+ WV+G IW
Sbjct: 450 FTIFLGLLVMNAA--DRFEGTKLLPNETSTDNAKQLFRMKTSCFSWMEMLIISWVIGMIW 507

Query: 416 GEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAF------------------- 456
            E K++W  G ++Y+ + WN++DF M +++ A+   + +AF                   
Sbjct: 508 AECKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDL 567

Query: 457 --------VKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQIS 508
                   VKY  L  R  WD   P +++E L+AIA + S  R+  +  AN   GPLQIS
Sbjct: 568 TKVTLGDNVKYYNL-ARIKWDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQIS 626

Query: 509 LGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETL 568
           LGR + DI KF+ I+ +V +AF  G+  LY YY   K           QN AF+T+ E+ 
Sbjct: 627 LGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAK-----------QNEAFTTVEESF 675

Query: 569 QSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIA 628
           ++LFW+IFGL  +    +   H+F E +G  ++G YNV  ++VLLNMLIAM+N+S+Q I 
Sbjct: 676 KTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIE 735

Query: 629 DHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLI----KWI----------W 674
           D AD+EWKFAR KLW SYFEEG TLP PFN++PSPKSL+YL+    KWI          +
Sbjct: 736 DDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLFYLLLKLKKWISELFQGHKKGF 795

Query: 675 THLCKKKMRRKPESFGTIG----------------------VRTQ---HRRAADNLRRHH 709
               +     + +  G +G                      +R+    H  + +N  R  
Sbjct: 796 QEDAEMNKINEEKKLGILGSHEDLSKLSLDKKQVGHNKQPSIRSSEDFHLNSFNNPPR-- 853

Query: 710 QYQEVMRNLVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRFEVL 756
           QYQ++M+ L+KRYV     D +++E + E   KE+KQDISS R+E+L
Sbjct: 854 QYQKIMKRLIKRYVLQAQIDKESDE-VNEGELKEIKQDISSLRYELL 899


>gi|169216484 PREDICTED: similar to transient receptor potential
           channel subfamily C member 6 [Homo sapiens]
          Length = 304

 Score =  200 bits (509), Expect = 5e-51
 Identities = 110/286 (38%), Positives = 160/286 (55%), Gaps = 39/286 (13%)

Query: 412 GFIWGEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAF--------------- 456
           G IW E K++W  G ++Y+ + WN++DF M ++  A+   +  AF               
Sbjct: 17  GMIWAECKEIWTQGPKEYLFELWNMLDFGMLAILSASFIARFRAFWHASKAQSITDASDT 76

Query: 457 ------------VKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGP 504
                       VKY +L  RE WD   P +V+E L A+A + S   +  +  AN   GP
Sbjct: 77  LKDLTKVTLGDNVKYYSLARRE-WDPSDPRMVSEGLCAVAVVLSFSGIACILPANESFGP 135

Query: 505 LQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTL 564
           LQ+SLG  + DI +F+ I+ +V +AF  G+  LY YY + K           QN AF+T+
Sbjct: 136 LQMSLGGAVKDIFRFMLIFIMVFVAFMIGMFNLYSYYIDVK-----------QNEAFTTV 184

Query: 565 FETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSY 624
            E+ ++LFW+ F L  +    +   H+F E +G  ++G Y+V  ++VLLNMLIAM+N+S 
Sbjct: 185 EESFKTLFWATFVLSAVKSVVINYSHKFIENIGYVLYGVYDVTMVIVLLNMLIAMINSSL 244

Query: 625 QLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLI 670
           Q I D AD+EWKFAR KLW S F EG  LP PFN++P P SL+ L+
Sbjct: 245 QEIEDDADVEWKFARAKLWFSCFGEGRALPVPFNLVPGPGSLFCLL 290


>gi|109689695 transient receptor potential cation channel, subfamily
            M, member 8 [Homo sapiens]
          Length = 1104

 Score =  109 bits (272), Expect = 1e-23
 Identities = 118/486 (24%), Positives = 208/486 (42%), Gaps = 60/486 (12%)

Query: 218  LTAFQLSWELQELSKVENEFKS--EYEELSRQCKQFAKDLLDQTRSSRE--LEIILNYRD 273
            L A   S  L+ L+KV+N+  +  E EEL+ + +  A +L  +  SS E   E +L Y  
Sbjct: 589  LAALGASKLLKTLAKVKNDINAAGESEELANEYETRAVELFTECYSSDEDLAEQLLVYS- 647

Query: 274  DNSLIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTC 333
                 E   G++   L+LA++   + F+AQP  Q  L+ +WY E      ++W  K++ C
Sbjct: 648  ----CEAWGGSNC--LELAVEATDQHFIAQPGVQNFLSKQWYGEISR-DTKNW--KIILC 698

Query: 334  FIIGLLFPVFSVCYLIAPKSPLG----------LFIRKPFIKFICHTASYLTFLFLLLLA 383
              I    P+    ++   K P+            F   PF+ F  +   Y+ FL L    
Sbjct: 699  LFI---IPLVGCGFVSFRKKPVDKHKKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFA-- 753

Query: 384  SQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQMWDGGLQDYIHDWWNLMDFVMNS 443
              ++   D +    PP +V + +   V      E++Q +  G+ +Y  D WN+MD +   
Sbjct: 754  --YVLLMDFHSVPHPPELVLYSL---VFVLFCDEVRQWYVNGV-NYFTDLWNVMDTLGLF 807

Query: 444  LYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLG 503
             ++A I  ++ +  K S  + R              +F +  I  +LRLI +FT + +LG
Sbjct: 808  YFIAGIVFRLHSSNKSSLYSGR-------------VIFCLDYIIFTLRLIHIFTVSRNLG 854

Query: 504  PLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAF-- 561
            P  I L RML+D+  FLF++ + ++AF      +    E+      + +  E     F  
Sbjct: 855  PKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIFRSVIYEPYLAMFGQ 914

Query: 562  ------STLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNM 615
                   T ++     F            +      F E++   +   Y + + ++L+N+
Sbjct: 915  VPSDVDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIPLVCIYMLSTNILLVNL 974

Query: 616  LIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWT 675
            L+AM   +   + ++ D  WKF R  L   Y      +P PF V       + ++K  + 
Sbjct: 975  LVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCSR-LNIPFPFIVF---AYFYMVVKKCFK 1030

Query: 676  HLCKKK 681
              CK+K
Sbjct: 1031 CCCKEK 1036


>gi|4507689 transient receptor potential cation channel, subfamily M,
            member 2 [Homo sapiens]
          Length = 1503

 Score = 91.7 bits (226), Expect = 3e-18
 Identities = 131/647 (20%), Positives = 242/647 (37%), Gaps = 111/647 (17%)

Query: 208  LIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEI 267
            +I   S+D    A   S  L+ELSK E +  S  E L+          L +    R + +
Sbjct: 640  IIWAQSQDCIAAALACSKILKELSKEEEDTDSSEEMLA----------LAEEYEHRAIGV 689

Query: 268  ILN-YRDDNSLIEE------QSGNDLARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFP- 319
                YR D    ++      ++      L+LA++ +  +FV+    Q  L   W+ +   
Sbjct: 690  FTECYRKDEERAQKLLTRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSV 749

Query: 320  --GWRRRHWAVKMVTCFIIGLL-FPVFSVCYLIAPKSPLGLFIRKPFIKFICHTASYLTF 376
              G  R    +      + GL+ F    +  +  P +    F   P + F  +  SY  F
Sbjct: 750  DNGLWRVTLCMLAFPLLLTGLISFREKRLQDVGTPAARARAFFTAPVVVFHLNILSYFAF 809

Query: 377  LFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQMW----DGGLQD---- 428
            L L      ++   D     P P+  E  I  W+   +  E++Q++    + GL      
Sbjct: 810  LCLFA----YVLMVDFQ---PVPSWCECAIYLWLFSLVCEEMRQLFYDPDECGLMKKAAL 862

Query: 429  YIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEALFAIANIFS 488
            Y  D+WN +D     L++A ++ +++    Y                    + ++  I  
Sbjct: 863  YFSDFWNKLDVGAILLFVAGLTCRLIPATLYPG----------------RVILSLDFILF 906

Query: 489  SLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLT 548
             LRL+ +FT +  LGP  I + RM+ D+  FLF+  + +++F      +  + E      
Sbjct: 907  CLRLMHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILIHNERRVDWL 966

Query: 549  CKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHE----------------- 591
             +G                +   + +IFG I  Y+  V    E                 
Sbjct: 967  FRG---------------AVYHSYLTIFGQIPGYIDGVNFNPEHCSPNGTDPYKPKCPES 1011

Query: 592  --------FTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLW 643
                    F E++   +   Y + + ++LLN+LIAM N ++Q + +H D  WKF R  L 
Sbjct: 1012 DATQQRPAFPEWLTVLLLCLYLLFTNILLLNLLIAMFNYTFQQVQEHTDQIWKFQRHDLI 1071

Query: 644  MSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLCKKKMRRKPESFGTIGVRTQHRRAAD 703
              Y       P PF ++   +     +         K+++ K E      + +      +
Sbjct: 1072 EEYHGRPAA-PPPFILLSHLQLFIKRVVLKTPAKRHKQLKNKLEKNEEAALLSWEIYLKE 1130

Query: 704  NLRRHHQYQEVMR---------NLVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRFE 754
            N  ++ Q+Q+  R         N V   V  +  D     G  E+    L++ ++     
Sbjct: 1131 NYLQNRQFQQKQRPEQKIEDISNKVDAMVDLLDLDPLKRSGSMEQRLASLEEQVAQTARA 1190

Query: 755  VLGLLRGSKLS---------TIQSANASKESSNSADSDEKSDSEGNS 792
            +  ++R  + S         T+ S  A++E        +K++  G+S
Sbjct: 1191 LHWIVRTLRASGFSSEADVPTLASQKAAEEPDAEPGGRKKTEEPGDS 1237


>gi|94538366 transient receptor potential cation channel, subfamily M,
            member 1 [Homo sapiens]
          Length = 1603

 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 112/558 (20%), Positives = 235/558 (42%), Gaps = 131/558 (23%)

Query: 231  SKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEI--ILNYRDDNSLIEEQSGNDLAR 288
            S + ++   + +  S+   Q A +LLDQ+    E     +L Y       E ++ ++   
Sbjct: 659  SDLVDDISQDLDNNSKDFGQLALELLDQSYKHDEQIAMKLLTY-------ELKNWSNSTC 711

Query: 289  LKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIG--LLFPVFSV- 345
            LKLA+  + ++F+A    Q LL   W        R++  +K++   ++   +LF  F   
Sbjct: 712  LKLAVAAKHRDFIAHTCSQMLLTDMWMGRLR--MRKNPGLKVIMGILLPPTILFLEFRTY 769

Query: 346  ---CYLIAPKS----------------------------------PLGL----FIRKPFI 364
                Y  + ++                                  P+G     F   P +
Sbjct: 770  DDFSYQTSKENEDGKEKEEENTDANADAGSRKGDEENEHKKQRSIPIGTKICEFYNAPIV 829

Query: 365  KFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQ--MW 422
            KF  +T SYL +L L            L R    P++ EW+++ +++     +I++  M 
Sbjct: 830  KFWFYTISYLGYLLLFNYVI-------LVRMDGWPSLQEWIVISYIVSLALEKIREILMS 882

Query: 423  DGG-----LQDYIHDWWNLMDFVMNSLYL--ATISLKIVAFVKYSALNPRESWDMWHPTL 475
            + G     ++ ++ ++WN+ D V  S ++  A + L+   ++ Y  +             
Sbjct: 883  EPGKLSQKIKVWLQEYWNITDLVAISTFMIGAILRLQNQPYMGYGRV------------- 929

Query: 476  VAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLN 535
                ++ +  IF  +R++ +F  N +LGP  + +G+M++D+L F+ I  +VL++F     
Sbjct: 930  ----IYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLMSF----- 980

Query: 536  QLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFG-----LINLYVTNVK--- 587
                      G+  + I   ++  ++          +W I+G      I+LY   +    
Sbjct: 981  ----------GVARQAILHPEEKPSWKLARNIFYMPYWMIYGEVFADQIDLYAMEINPPC 1030

Query: 588  AQHEFTE------------FVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEW 635
             ++ + E            ++   +   Y +++ ++L+N+LIA+ NN++  +   ++  W
Sbjct: 1031 GENLYDEEGKRLPPCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVW 1090

Query: 636  KFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLCKKKMRRKPESFGTIGVR 695
            KF R +L M+ F +   LP P  ++    S  Y+I    +  C+KK R   +     G++
Sbjct: 1091 KFQRYQLIMT-FHDRPVLPPPMIIL----SHIYIIIMRLSGRCRKK-REGDQEERDRGLK 1144

Query: 696  TQHRRAADNLRRHHQYQE 713
                 + + L+R H+++E
Sbjct: 1145 L--FLSDEELKRLHEFEE 1160


>gi|18921093 transient receptor potential cation channel, subfamily M,
            member 6 [Homo sapiens]
          Length = 2022

 Score = 84.0 bits (206), Expect = 6e-16
 Identities = 92/436 (21%), Positives = 179/436 (41%), Gaps = 74/436 (16%)

Query: 358  FIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGE 417
            F   P +KF  +T +YL FL L            L    P P++ EW++  ++       
Sbjct: 834  FYSAPIVKFWFYTMAYLAFLMLFTYTV-------LVEMQPQPSVQEWLVSIYIFTNAIEV 886

Query: 418  IKQM-------WDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDM 470
            ++++       +   ++ +I ++WNL + V   L+ A   L+               W  
Sbjct: 887  VREICISEPGKFTQKVKVWISEYWNLTETVAIGLFSAGFVLR---------------WGD 931

Query: 471  WHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 530
                     ++ I  IF   RL+  F  N H GP    + +M  ++   + I  +VLL+F
Sbjct: 932  PPFHTAGRLIYCIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMTANMFYIVIIMAIVLLSF 991

Query: 531  ANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLI---NLYVTNVK 587
                           G+  K I   K+  ++S   + +   +W I+G +    + V + +
Sbjct: 992  ---------------GVARKAILSPKEPPSWSLARDIVFEPYWMIYGEVYAGEIDVCSSQ 1036

Query: 588  AQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYF 647
                   F+   +   Y  +  ++++N+LIA  NN Y  +   ++  WK+ R +  M+Y 
Sbjct: 1037 PSCPPGSFLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESISNNLWKYNRYRYIMTYH 1096

Query: 648  EEGGTLPTPFNVIPSPKSLWYLIKWIWTHLCKKKMRRKPESFGTIGVRTQHRRAADNLRR 707
            E+      P+  +P P  L   +  +   LC  +     E  G +G++     + ++L++
Sbjct: 1097 EK------PW--LPPPLILLSHVGLLLRRLCCHRAPHDQEE-GDVGLKLY--LSKEDLKK 1145

Query: 708  HHQYQEVMRNLVKRYVAAMIRDAK---------TEEGLTEENF--KELKQDISSFRFEVL 756
             H ++E     V++Y    + D           T E +TE  F  KE+ + +S  +  +L
Sbjct: 1146 LHDFEE---QCVEKYFHEKMEDVNCSCEERIRVTSERVTEMYFQLKEMNEKVSFIKDSLL 1202

Query: 757  GLLRGSKLSTIQSANA 772
             L   S++  +Q  +A
Sbjct: 1203 SL--DSQVGHLQDLSA 1216


>gi|148612863 transient receptor potential cation channel, subfamily
            M, member 7 [Homo sapiens]
          Length = 1865

 Score = 83.6 bits (205), Expect = 8e-16
 Identities = 80/343 (23%), Positives = 148/343 (43%), Gaps = 52/343 (15%)

Query: 358  FIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGE 417
            F   P +KF  +T +YL FL L            L +    P++ EW+++ ++  +   +
Sbjct: 848  FYHAPIVKFWFNTLAYLGFLMLYTFVV-------LVQMEQLPSVQEWIVIAYIFTYAIEK 900

Query: 418  IKQMW---DGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSAL-NPRESWDMWHP 473
            +++++    G +   I  W++  D+   S  +A IS  I   +++ A  N   ++D  H 
Sbjct: 901  VREIFMSEAGKVNQKIKVWFS--DYFNISDTIAIISFFIGFGLRFGAKWNFANAYDN-HV 957

Query: 474  TLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANG 533
             +    ++ +  IF  +RL+     N   GP  + +G+M+ ++   + I  LVLL+F   
Sbjct: 958  FVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVP 1017

Query: 534  LNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHE-- 591
               + + +E       K I           +F      +W IFG +  Y  +V A     
Sbjct: 1018 RKAILYPHEAPSWTLAKDI-----------VFHP----YWMIFGEVYAYEIDVCANDSVI 1062

Query: 592  ---------FTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKL 642
                      T F+ A     Y  +  ++++N+LIA  NN Y  +   ++I WK+ R   
Sbjct: 1063 PQICGPGTWLTPFLQAV----YLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHF 1118

Query: 643  WMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLCKKKMRRK 685
             M+Y E+   LP P  ++    SL+  I       CK++ + K
Sbjct: 1119 IMAYHEK-PVLPPPLIILSHIVSLFCCI-------CKRRKKDK 1153



 Score = 30.4 bits (67), Expect = 8.5
 Identities = 26/98 (26%), Positives = 43/98 (43%), Gaps = 10/98 (10%)

Query: 231 SKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEI--ILNYRDDNSLIEEQSGNDLAR 288
           S + ++   E ++ S    Q A +LL+Q+    E     +L Y       E ++ ++   
Sbjct: 669 SDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTY-------ELKNWSNSTC 721

Query: 289 LKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHW 326
           LKLA+  R + FVA    Q LL+  W       R+  W
Sbjct: 722 LKLAVSSRLRPFVAHTCTQMLLSDMWMGRL-NMRKNSW 758


>gi|239754785 PREDICTED: similar to transient receptor potential
           cation channel, subfamily C, member 6, partial [Homo
           sapiens]
          Length = 182

 Score = 80.1 bits (196), Expect = 9e-15
 Identities = 56/180 (31%), Positives = 82/180 (45%), Gaps = 39/180 (21%)

Query: 417 EIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAF-------------------- 456
           E K++W  G ++Y+ + WN++DF M  ++ A    +  AF                    
Sbjct: 4   ECKEIWTQGPKEYLFELWNMLDFGMLVIFTALFIARFRAFWHASKAQSIIDANDTLKDLT 63

Query: 457 -------VKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISL 509
                  VKY  L  RE W    P +V+E L A+A + S   +  +  AN   GPLQ SL
Sbjct: 64  EVTLGDNVKYYNLARRE-WVPSDPWVVSEGLCAVAVVLSFSGIACILPANESFGPLQTSL 122

Query: 510 GRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQ 569
           G  + DI +F+ I+ +V +AF  G+  LY YY              KQN AF+TL   L+
Sbjct: 123 GGAVKDIFRFMVIFIMVFVAFMIGMFNLYSYYIGA-----------KQNEAFTTLKRVLR 171


>gi|239749299 PREDICTED: similar to transient receptor potential
           cation channel, subfamily C, member 6, partial [Homo
           sapiens]
          Length = 182

 Score = 80.1 bits (196), Expect = 9e-15
 Identities = 56/180 (31%), Positives = 82/180 (45%), Gaps = 39/180 (21%)

Query: 417 EIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAF-------------------- 456
           E K++W  G ++Y+ + WN++DF M  ++ A    +  AF                    
Sbjct: 4   ECKEIWTQGPKEYLFELWNMLDFGMLVIFTALFIARFRAFWHASKAQSIIDANDTLKDLT 63

Query: 457 -------VKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISL 509
                  VKY  L  RE W    P +V+E L A+A + S   +  +  AN   GPLQ SL
Sbjct: 64  EVTLGDNVKYYNLARRE-WVPSDPWVVSEGLCAVAVVLSFSGIACILPANESFGPLQTSL 122

Query: 510 GRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQ 569
           G  + DI +F+ I+ +V +AF  G+  LY YY              KQN AF+TL   L+
Sbjct: 123 GGAVKDIFRFMVIFIMVFVAFMIGMFNLYSYYIGA-----------KQNEAFTTLKRVLR 171


>gi|239743393 PREDICTED: hypothetical protein XP_002342847, partial
           [Homo sapiens]
          Length = 182

 Score = 80.1 bits (196), Expect = 9e-15
 Identities = 56/180 (31%), Positives = 82/180 (45%), Gaps = 39/180 (21%)

Query: 417 EIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAF-------------------- 456
           E K++W  G ++Y+ + WN++DF M  ++ A    +  AF                    
Sbjct: 4   ECKEIWTQGPKEYLFELWNMLDFGMLVIFTALFIARFRAFWHASKAQSIIDANDTLKDLT 63

Query: 457 -------VKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISL 509
                  VKY  L  RE W    P +V+E L A+A + S   +  +  AN   GPLQ SL
Sbjct: 64  EVTLGDNVKYYNLARRE-WVPSDPWVVSEGLCAVAVVLSFSGIACILPANESFGPLQTSL 122

Query: 510 GRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQ 569
           G  + DI +F+ I+ +V +AF  G+  LY YY              KQN AF+TL   L+
Sbjct: 123 GGAVKDIFRFMVIFIMVFVAFMIGMFNLYSYYIGA-----------KQNEAFTTLKRVLR 171


>gi|239509090 PREDICTED: similar to transient receptor potential
           cation channel, subfamily C, member 6, partial [Homo
           sapiens]
          Length = 182

 Score = 80.1 bits (196), Expect = 9e-15
 Identities = 56/180 (31%), Positives = 82/180 (45%), Gaps = 39/180 (21%)

Query: 417 EIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAF-------------------- 456
           E K++W  G ++Y+ + WN++DF M  ++ A    +  AF                    
Sbjct: 4   ECKEIWTQGPKEYLFELWNMLDFGMLVIFTALFIARFRAFWHASKAQSIIDANDTLKDLT 63

Query: 457 -------VKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISL 509
                  VKY  L  RE W    P +V+E L A+A + S   +  +  AN   GPLQ SL
Sbjct: 64  EVTLGDNVKYYNLARRE-WVPSDPWVVSEGLCAVAVVLSFSGIACILPANESFGPLQTSL 122

Query: 510 GRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQ 569
           G  + DI +F+ I+ +V +AF  G+  LY YY              KQN AF+TL   L+
Sbjct: 123 GGAVKDIFRFMVIFIMVFVAFMIGMFNLYSYYIGA-----------KQNEAFTTLKRVLR 171


>gi|154091312 transient receptor potential cation channel, subfamily
            M, member 3 isoform b [Homo sapiens]
          Length = 1566

 Score = 78.2 bits (191), Expect = 4e-14
 Identities = 71/343 (20%), Positives = 150/343 (43%), Gaps = 67/343 (19%)

Query: 358  FIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGE 417
            F   P +KF  +T +Y+ +L L      +I    + R    P+  EW+++ ++      +
Sbjct: 724  FYNAPIVKFWFYTLAYIGYLMLF----NYIVLVKMERW---PSTQEWIVISYIFTLGIEK 776

Query: 418  IKQ--MWDGG-----LQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDM 470
            +++  M + G     ++ ++ ++WN+ D +   L+   + L++          P  S   
Sbjct: 777  MREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQD-------QPFRS--- 826

Query: 471  WHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 530
                     ++ +  I+  +RL+ +F  N +LGP  + +G+M++D++ F+ I  +VL++F
Sbjct: 827  -----DGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSF 881

Query: 531  ANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINL-YVTNVKAQ 589
                  + F  EE      K I                   +W I+G +    +     Q
Sbjct: 882  GVARQAILFPNEEPSWKLAKNI---------------FYMPYWMIYGEVFADQIDPPCGQ 926

Query: 590  HEFTE--------------FVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEW 635
            +E  E              ++   +   Y +++ ++L+N+LIA+ NN++  +   ++  W
Sbjct: 927  NETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVW 986

Query: 636  KFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLC 678
            KF R +L M++ E          V+P P  ++  +  I+ HLC
Sbjct: 987  KFQRYQLIMTFHER--------PVLPPPLIIFSHMTMIFQHLC 1021



 Score = 32.0 bits (71), Expect = 2.9
 Identities = 28/113 (24%), Positives = 49/113 (43%), Gaps = 23/113 (20%)

Query: 235 NEFKSEYEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLI------EEQSGNDLAR 288
           ++   E    SR   Q A +LLDQ+           Y+ D  L       E ++ ++   
Sbjct: 546 DDISQELNHNSRDFGQLAVELLDQS-----------YKQDEQLAMKLLTYELKNWSNATC 594

Query: 289 LKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFP 341
           L+LA+  + ++F+A    Q LL   W        R++  +K+    I+G+L P
Sbjct: 595 LQLAVAAKHRDFIAHTCSQMLLTDMWMGRLR--MRKNSGLKV----ILGILLP 641


>gi|154091308 transient receptor potential cation channel, subfamily
            M, member 3 isoform f [Homo sapiens]
          Length = 1579

 Score = 78.2 bits (191), Expect = 4e-14
 Identities = 71/343 (20%), Positives = 150/343 (43%), Gaps = 67/343 (19%)

Query: 358  FIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGE 417
            F   P +KF  +T +Y+ +L L      +I    + R    P+  EW+++ ++      +
Sbjct: 737  FYNAPIVKFWFYTLAYIGYLMLF----NYIVLVKMERW---PSTQEWIVISYIFTLGIEK 789

Query: 418  IKQ--MWDGG-----LQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDM 470
            +++  M + G     ++ ++ ++WN+ D +   L+   + L++          P  S   
Sbjct: 790  MREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQD-------QPFRS--- 839

Query: 471  WHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 530
                     ++ +  I+  +RL+ +F  N +LGP  + +G+M++D++ F+ I  +VL++F
Sbjct: 840  -----DGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSF 894

Query: 531  ANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINL-YVTNVKAQ 589
                  + F  EE      K I                   +W I+G +    +     Q
Sbjct: 895  GVARQAILFPNEEPSWKLAKNI---------------FYMPYWMIYGEVFADQIDPPCGQ 939

Query: 590  HEFTE--------------FVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEW 635
            +E  E              ++   +   Y +++ ++L+N+LIA+ NN++  +   ++  W
Sbjct: 940  NETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVW 999

Query: 636  KFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLC 678
            KF R +L M++ E          V+P P  ++  +  I+ HLC
Sbjct: 1000 KFQRYQLIMTFHER--------PVLPPPLIIFSHMTMIFQHLC 1034



 Score = 32.0 bits (71), Expect = 2.9
 Identities = 28/113 (24%), Positives = 49/113 (43%), Gaps = 23/113 (20%)

Query: 235 NEFKSEYEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLI------EEQSGNDLAR 288
           ++   E    SR   Q A +LLDQ+           Y+ D  L       E ++ ++   
Sbjct: 559 DDISQELNHNSRDFGQLAVELLDQS-----------YKQDEQLAMKLLTYELKNWSNATC 607

Query: 289 LKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFP 341
           L+LA+  + ++F+A    Q LL   W        R++  +K+    I+G+L P
Sbjct: 608 LQLAVAAKHRDFIAHTCSQMLLTDMWMGRLR--MRKNSGLKV----ILGILLP 654


>gi|154091310 transient receptor potential cation channel, subfamily
            M, member 3 isoform g [Homo sapiens]
          Length = 1569

 Score = 78.2 bits (191), Expect = 4e-14
 Identities = 71/343 (20%), Positives = 150/343 (43%), Gaps = 67/343 (19%)

Query: 358  FIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGE 417
            F   P +KF  +T +Y+ +L L      +I    + R    P+  EW+++ ++      +
Sbjct: 727  FYNAPIVKFWFYTLAYIGYLMLF----NYIVLVKMERW---PSTQEWIVISYIFTLGIEK 779

Query: 418  IKQ--MWDGG-----LQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDM 470
            +++  M + G     ++ ++ ++WN+ D +   L+   + L++          P  S   
Sbjct: 780  MREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQD-------QPFRS--- 829

Query: 471  WHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 530
                     ++ +  I+  +RL+ +F  N +LGP  + +G+M++D++ F+ I  +VL++F
Sbjct: 830  -----DGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSF 884

Query: 531  ANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINL-YVTNVKAQ 589
                  + F  EE      K I                   +W I+G +    +     Q
Sbjct: 885  GVARQAILFPNEEPSWKLAKNI---------------FYMPYWMIYGEVFADQIDPPCGQ 929

Query: 590  HEFTE--------------FVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEW 635
            +E  E              ++   +   Y +++ ++L+N+LIA+ NN++  +   ++  W
Sbjct: 930  NETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVW 989

Query: 636  KFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLC 678
            KF R +L M++ E          V+P P  ++  +  I+ HLC
Sbjct: 990  KFQRYQLIMTFHER--------PVLPPPLIIFSHMTMIFQHLC 1024



 Score = 32.0 bits (71), Expect = 2.9
 Identities = 28/113 (24%), Positives = 49/113 (43%), Gaps = 23/113 (20%)

Query: 235 NEFKSEYEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLI------EEQSGNDLAR 288
           ++   E    SR   Q A +LLDQ+           Y+ D  L       E ++ ++   
Sbjct: 549 DDISQELNHNSRDFGQLAVELLDQS-----------YKQDEQLAMKLLTYELKNWSNATC 597

Query: 289 LKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFP 341
           L+LA+  + ++F+A    Q LL   W        R++  +K+    I+G+L P
Sbjct: 598 LQLAVAAKHRDFIAHTCSQMLLTDMWMGRLR--MRKNSGLKV----ILGILLP 644


>gi|154091320 transient receptor potential cation channel, subfamily
            M, member 3 isoform a [Homo sapiens]
          Length = 1554

 Score = 78.2 bits (191), Expect = 4e-14
 Identities = 71/343 (20%), Positives = 150/343 (43%), Gaps = 67/343 (19%)

Query: 358  FIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGE 417
            F   P +KF  +T +Y+ +L L      +I    + R    P+  EW+++ ++      +
Sbjct: 712  FYNAPIVKFWFYTLAYIGYLMLF----NYIVLVKMERW---PSTQEWIVISYIFTLGIEK 764

Query: 418  IKQ--MWDGG-----LQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDM 470
            +++  M + G     ++ ++ ++WN+ D +   L+   + L++          P  S   
Sbjct: 765  MREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQD-------QPFRS--- 814

Query: 471  WHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 530
                     ++ +  I+  +RL+ +F  N +LGP  + +G+M++D++ F+ I  +VL++F
Sbjct: 815  -----DGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSF 869

Query: 531  ANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINL-YVTNVKAQ 589
                  + F  EE      K I                   +W I+G +    +     Q
Sbjct: 870  GVARQAILFPNEEPSWKLAKNI---------------FYMPYWMIYGEVFADQIDPPCGQ 914

Query: 590  HEFTE--------------FVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEW 635
            +E  E              ++   +   Y +++ ++L+N+LIA+ NN++  +   ++  W
Sbjct: 915  NETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVW 974

Query: 636  KFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLC 678
            KF R +L M++ E          V+P P  ++  +  I+ HLC
Sbjct: 975  KFQRYQLIMTFHER--------PVLPPPLIIFSHMTMIFQHLC 1009



 Score = 32.0 bits (71), Expect = 2.9
 Identities = 28/113 (24%), Positives = 49/113 (43%), Gaps = 23/113 (20%)

Query: 235 NEFKSEYEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLI------EEQSGNDLAR 288
           ++   E    SR   Q A +LLDQ+           Y+ D  L       E ++ ++   
Sbjct: 534 DDISQELNHNSRDFGQLAVELLDQS-----------YKQDEQLAMKLLTYELKNWSNATC 582

Query: 289 LKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFP 341
           L+LA+  + ++F+A    Q LL   W        R++  +K+    I+G+L P
Sbjct: 583 LQLAVAAKHRDFIAHTCSQMLLTDMWMGRLR--MRKNSGLKV----ILGILLP 629


>gi|154091318 transient receptor potential cation channel, subfamily
           M, member 3 isoform d [Homo sapiens]
          Length = 1544

 Score = 78.2 bits (191), Expect = 4e-14
 Identities = 71/343 (20%), Positives = 150/343 (43%), Gaps = 67/343 (19%)

Query: 358 FIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGE 417
           F   P +KF  +T +Y+ +L L      +I    + R    P+  EW+++ ++      +
Sbjct: 702 FYNAPIVKFWFYTLAYIGYLMLF----NYIVLVKMERW---PSTQEWIVISYIFTLGIEK 754

Query: 418 IKQ--MWDGG-----LQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDM 470
           +++  M + G     ++ ++ ++WN+ D +   L+   + L++          P  S   
Sbjct: 755 MREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQD-------QPFRS--- 804

Query: 471 WHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 530
                    ++ +  I+  +RL+ +F  N +LGP  + +G+M++D++ F+ I  +VL++F
Sbjct: 805 -----DGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSF 859

Query: 531 ANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINL-YVTNVKAQ 589
                 + F  EE      K I                   +W I+G +    +     Q
Sbjct: 860 GVARQAILFPNEEPSWKLAKNI---------------FYMPYWMIYGEVFADQIDPPCGQ 904

Query: 590 HEFTE--------------FVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEW 635
           +E  E              ++   +   Y +++ ++L+N+LIA+ NN++  +   ++  W
Sbjct: 905 NETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVW 964

Query: 636 KFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLC 678
           KF R +L M++ E          V+P P  ++  +  I+ HLC
Sbjct: 965 KFQRYQLIMTFHER--------PVLPPPLIIFSHMTMIFQHLC 999



 Score = 32.0 bits (71), Expect = 2.9
 Identities = 28/113 (24%), Positives = 49/113 (43%), Gaps = 23/113 (20%)

Query: 235 NEFKSEYEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLI------EEQSGNDLAR 288
           ++   E    SR   Q A +LLDQ+           Y+ D  L       E ++ ++   
Sbjct: 524 DDISQELNHNSRDFGQLAVELLDQS-----------YKQDEQLAMKLLTYELKNWSNATC 572

Query: 289 LKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFP 341
           L+LA+  + ++F+A    Q LL   W        R++  +K+    I+G+L P
Sbjct: 573 LQLAVAAKHRDFIAHTCSQMLLTDMWMGRLR--MRKNSGLKV----ILGILLP 619


>gi|154091316 transient receptor potential cation channel, subfamily
            M, member 3 isoform e [Homo sapiens]
          Length = 1556

 Score = 78.2 bits (191), Expect = 4e-14
 Identities = 71/343 (20%), Positives = 150/343 (43%), Gaps = 67/343 (19%)

Query: 358  FIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGE 417
            F   P +KF  +T +Y+ +L L      +I    + R    P+  EW+++ ++      +
Sbjct: 714  FYNAPIVKFWFYTLAYIGYLMLF----NYIVLVKMERW---PSTQEWIVISYIFTLGIEK 766

Query: 418  IKQ--MWDGG-----LQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDM 470
            +++  M + G     ++ ++ ++WN+ D +   L+   + L++          P  S   
Sbjct: 767  MREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQD-------QPFRS--- 816

Query: 471  WHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 530
                     ++ +  I+  +RL+ +F  N +LGP  + +G+M++D++ F+ I  +VL++F
Sbjct: 817  -----DGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSF 871

Query: 531  ANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINL-YVTNVKAQ 589
                  + F  EE      K I                   +W I+G +    +     Q
Sbjct: 872  GVARQAILFPNEEPSWKLAKNI---------------FYMPYWMIYGEVFADQIDPPCGQ 916

Query: 590  HEFTE--------------FVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEW 635
            +E  E              ++   +   Y +++ ++L+N+LIA+ NN++  +   ++  W
Sbjct: 917  NETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVW 976

Query: 636  KFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLC 678
            KF R +L M++ E          V+P P  ++  +  I+ HLC
Sbjct: 977  KFQRYQLIMTFHER--------PVLPPPLIIFSHMTMIFQHLC 1011



 Score = 32.0 bits (71), Expect = 2.9
 Identities = 28/113 (24%), Positives = 49/113 (43%), Gaps = 23/113 (20%)

Query: 235 NEFKSEYEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLI------EEQSGNDLAR 288
           ++   E    SR   Q A +LLDQ+           Y+ D  L       E ++ ++   
Sbjct: 536 DDISQELNHNSRDFGQLAVELLDQS-----------YKQDEQLAMKLLTYELKNWSNATC 584

Query: 289 LKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFP 341
           L+LA+  + ++F+A    Q LL   W        R++  +K+    I+G+L P
Sbjct: 585 LQLAVAAKHRDFIAHTCSQMLLTDMWMGRLR--MRKNSGLKV----ILGILLP 631


>gi|154091314 transient receptor potential cation channel, subfamily
            M, member 3 isoform k [Homo sapiens]
          Length = 1707

 Score = 78.2 bits (191), Expect = 4e-14
 Identities = 71/343 (20%), Positives = 150/343 (43%), Gaps = 67/343 (19%)

Query: 358  FIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGE 417
            F   P +KF  +T +Y+ +L L      +I    + R    P+  EW+++ ++      +
Sbjct: 865  FYNAPIVKFWFYTLAYIGYLMLF----NYIVLVKMERW---PSTQEWIVISYIFTLGIEK 917

Query: 418  IKQ--MWDGG-----LQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDM 470
            +++  M + G     ++ ++ ++WN+ D +   L+   + L++          P  S   
Sbjct: 918  MREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQD-------QPFRS--- 967

Query: 471  WHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 530
                     ++ +  I+  +RL+ +F  N +LGP  + +G+M++D++ F+ I  +VL++F
Sbjct: 968  -----DGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSF 1022

Query: 531  ANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINL-YVTNVKAQ 589
                  + F  EE      K I                   +W I+G +    +     Q
Sbjct: 1023 GVARQAILFPNEEPSWKLAKNI---------------FYMPYWMIYGEVFADQIDPPCGQ 1067

Query: 590  HEFTE--------------FVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEW 635
            +E  E              ++   +   Y +++ ++L+N+LIA+ NN++  +   ++  W
Sbjct: 1068 NETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVW 1127

Query: 636  KFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLC 678
            KF R +L M++ E          V+P P  ++  +  I+ HLC
Sbjct: 1128 KFQRYQLIMTFHER--------PVLPPPLIIFSHMTMIFQHLC 1162



 Score = 32.0 bits (71), Expect = 2.9
 Identities = 28/113 (24%), Positives = 49/113 (43%), Gaps = 23/113 (20%)

Query: 235 NEFKSEYEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLI------EEQSGNDLAR 288
           ++   E    SR   Q A +LLDQ+           Y+ D  L       E ++ ++   
Sbjct: 687 DDISQELNHNSRDFGQLAVELLDQS-----------YKQDEQLAMKLLTYELKNWSNATC 735

Query: 289 LKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFP 341
           L+LA+  + ++F+A    Q LL   W        R++  +K+    I+G+L P
Sbjct: 736 LQLAVAAKHRDFIAHTCSQMLLTDMWMGRLR--MRKNSGLKV----ILGILLP 782


>gi|11225266 transient receptor potential cation channel, subfamily M,
            member 5 [Homo sapiens]
          Length = 1165

 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 73/323 (22%), Positives = 125/323 (38%), Gaps = 66/323 (20%)

Query: 362  PFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQM 421
            P   F+ +   Y  FLFL      ++   D       P+  E  +  WV   +  EI+Q 
Sbjct: 731  PVTVFLGNVVMYFAFLFLFT----YVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQ- 785

Query: 422  WDGGLQD-----------YIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDM 470
              G   D           Y+ D WN  D V   L++  ++ +++     SA         
Sbjct: 786  --GFFTDEDTHLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLP----SAFE------- 832

Query: 471  WHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAF 530
                     + A+  +  +LRLI +F  +  LGP  I + RM+ D+  FLF   + L+A+
Sbjct: 833  -----AGRTVLAMDFMVFTLRLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAY 887

Query: 531  ANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINL--------- 581
                           G+T + +               L   +  IFG I L         
Sbjct: 888  ---------------GVTTQALLHPHDGRLEWIFRRVLYRPYLQIFGQIPLDEIDEARVN 932

Query: 582  -------YVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIE 634
                      +      +  ++   +  T+ +++ V+L+N+LIAM + ++Q++  +AD+ 
Sbjct: 933  CSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMF 992

Query: 635  WKFARTKLWMSYFEEGGTLPTPF 657
            WKF R  L + Y E     P PF
Sbjct: 993  WKFQRYNLIVEYHERPALAP-PF 1014


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.136    0.403 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,510,987
Number of Sequences: 37866
Number of extensions: 1548840
Number of successful extensions: 6001
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 89
Number of HSP's successfully gapped in prelim test: 97
Number of HSP's that attempted gapping in prelim test: 5317
Number of HSP's gapped (non-prelim): 711
length of query: 982
length of database: 18,247,518
effective HSP length: 112
effective length of query: 870
effective length of database: 14,006,526
effective search space: 12185677620
effective search space used: 12185677620
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.