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Search of human proteins with 209364621
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|209364621 pregnancy upregulated non-ubiquitously expressed
CaM kinase isoform b [Homo sapiens]
(360 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|209364621 pregnancy upregulated non-ubiquitously expressed Ca... 730 0.0
gi|209364619 pregnancy upregulated non-ubiquitously expressed Ca... 696 0.0
gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo s... 458 e-129
gi|9966875 calcium/calmodulin-dependent protein kinase ID isofor... 457 e-129
gi|23943850 calcium/calmodulin-dependent protein kinase ID isofo... 457 e-129
gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo... 410 e-114
gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo ... 278 7e-75
gi|83776596 CaM kinase-like vesicle-associated [Homo sapiens] 271 9e-73
gi|27901803 protein serine kinase H1 [Homo sapiens] 258 8e-69
gi|4758128 doublecortin-like kinase 1 [Homo sapiens] 254 6e-68
gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens] 245 4e-65
gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens] 245 4e-65
gi|14916455 protein serine kinase H2 [Homo sapiens] 235 4e-62
gi|25952118 calcium/calmodulin-dependent protein kinase II alpha... 230 2e-60
gi|25952114 calcium/calmodulin-dependent protein kinase II alpha... 230 2e-60
gi|26667196 calcium/calmodulin-dependent protein kinase II gamma... 229 4e-60
gi|149589021 doublecortin-like kinase 3 [Homo sapiens] 226 2e-59
gi|26667199 calcium/calmodulin-dependent protein kinase II gamma... 226 3e-59
gi|26667191 calcium/calmodulin-dependent protein kinase II gamma... 226 3e-59
gi|26667211 calcium/calmodulin-dependent protein kinase II gamma... 226 3e-59
gi|26667203 calcium/calmodulin-dependent protein kinase II gamma... 226 3e-59
gi|212549756 calcium/calmodulin-dependent protein kinase II delt... 224 9e-59
gi|26667183 calcium/calmodulin-dependent protein kinase II delta... 224 9e-59
gi|212549753 calcium/calmodulin-dependent protein kinase II delt... 224 9e-59
gi|26667186 calcium/calmodulin-dependent protein kinase II delta... 224 9e-59
gi|26667189 calcium/calmodulin-dependent protein kinase II delta... 224 9e-59
gi|26667180 calcium/calmodulin-dependent protein kinase II delta... 224 9e-59
gi|26051204 calcium/calmodulin-dependent protein kinase II beta ... 221 6e-58
gi|26051210 calcium/calmodulin-dependent protein kinase II beta ... 221 6e-58
gi|26051214 calcium/calmodulin-dependent protein kinase II beta ... 221 6e-58
>gi|209364621 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform b [Homo sapiens]
Length = 360
Score = 730 bits (1885), Expect = 0.0
Identities = 360/360 (100%), Positives = 360/360 (100%)
Query: 1 MWRRVCGGLAGRRPSGDMLLLKKHTEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVAL 60
MWRRVCGGLAGRRPSGDMLLLKKHTEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVAL
Sbjct: 1 MWRRVCGGLAGRRPSGDMLLLKKHTEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVAL 60
Query: 61 KCIPKKALRGKEALVENEIAVLRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIM 120
KCIPKKALRGKEALVENEIAVLRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIM
Sbjct: 61 KCIPKKALRGKEALVENEIAVLRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIM 120
Query: 121 ERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKI 180
ERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKI
Sbjct: 121 ERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKI 180
Query: 181 QAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQ 240
QAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQ
Sbjct: 181 QAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQ 240
Query: 241 ILRASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGS 300
ILRASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGS
Sbjct: 241 ILRASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGS 300
Query: 301 VSEQIRKNFARTHWKRAFNATSFLRHIRKLGQIPEGEGASEQGMARHSHSGLRAGQPPKW 360
VSEQIRKNFARTHWKRAFNATSFLRHIRKLGQIPEGEGASEQGMARHSHSGLRAGQPPKW
Sbjct: 301 VSEQIRKNFARTHWKRAFNATSFLRHIRKLGQIPEGEGASEQGMARHSHSGLRAGQPPKW 360
>gi|209364619 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform a [Homo sapiens]
Length = 426
Score = 696 bits (1797), Expect = 0.0
Identities = 349/360 (96%), Positives = 349/360 (96%), Gaps = 7/360 (1%)
Query: 8 GLAGRRPSG-------DMLLLKKHTEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVAL 60
G GR PS DMLLLKKHTEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVAL
Sbjct: 67 GGGGRHPSRIPAIALQDMLLLKKHTEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVAL 126
Query: 61 KCIPKKALRGKEALVENEIAVLRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIM 120
KCIPKKALRGKEALVENEIAVLRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIM
Sbjct: 127 KCIPKKALRGKEALVENEIAVLRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIM 186
Query: 121 ERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKI 180
ERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKI
Sbjct: 187 ERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKI 246
Query: 181 QAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQ 240
QAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQ
Sbjct: 247 QAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQ 306
Query: 241 ILRASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGS 300
ILRASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGS
Sbjct: 307 ILRASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGS 366
Query: 301 VSEQIRKNFARTHWKRAFNATSFLRHIRKLGQIPEGEGASEQGMARHSHSGLRAGQPPKW 360
VSEQIRKNFARTHWKRAFNATSFLRHIRKLGQIPEGEGASEQGMARHSHSGLRAGQPPKW
Sbjct: 367 VSEQIRKNFARTHWKRAFNATSFLRHIRKLGQIPEGEGASEQGMARHSHSGLRAGQPPKW 426
>gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo
sapiens]
Length = 370
Score = 458 bits (1179), Expect = e-129
Identities = 219/319 (68%), Positives = 272/319 (85%), Gaps = 3/319 (0%)
Query: 23 KHTEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVL 82
K EDI +Y+ R+ LG+GAFSEV+LA+++ + LVA+KCI K+AL GKE +ENEIAVL
Sbjct: 11 KQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVL 70
Query: 83 RRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVS 142
+I HPNIVAL+D++ES HLYL M+LV+GGELFDRI+E+G YTE+DAS L+ QVL AV
Sbjct: 71 HKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVK 130
Query: 143 YLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQ-AGNMLGTACGTPGYVAPELL 201
YLH LGIVHRDLKPENLLY + EDSKIM+SDFGLSK++ G++L TACGTPGYVAPE+L
Sbjct: 131 YLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVL 190
Query: 202 EQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAK 261
QKPY KAVD W++GVI+YILLCGYPPFYDE+D +LF QIL+A YEFDSP+WDDIS+SAK
Sbjct: 191 AQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAK 250
Query: 262 DFIRHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGSVSEQIRKNFARTHWKRAFNAT 321
DFIRHL+E+DP+KRFTC+QAL+H WI+GDTA D++I SVSEQI+KNFA++ WK+AFNAT
Sbjct: 251 DFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNFAKSKWKQAFNAT 310
Query: 322 SFLRHIRK--LGQIPEGEG 338
+ +RH+RK LG EG+G
Sbjct: 311 AVVRHMRKLQLGTSQEGQG 329
>gi|9966875 calcium/calmodulin-dependent protein kinase ID isoform 1
[Homo sapiens]
Length = 357
Score = 457 bits (1177), Expect = e-129
Identities = 215/310 (69%), Positives = 269/310 (86%), Gaps = 1/310 (0%)
Query: 22 KKHTEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAV 81
KK EDI ++E +E LG+GAFSEVVLA+E+ + L A+KCIPKKAL+GKE+ +ENEIAV
Sbjct: 13 KKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAV 72
Query: 82 LRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAV 141
LR+I H NIVALED++ESP+HLYL M+LV+GGELFDRI+E+G YTEKDAS L+ QVL AV
Sbjct: 73 LRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAV 132
Query: 142 SYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQA-GNMLGTACGTPGYVAPEL 200
YLH +GIVHRDLKPENLLY + E+SKIM+SDFGLSK++ G+++ TACGTPGYVAPE+
Sbjct: 133 YYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEV 192
Query: 201 LEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESA 260
L QKPY KAVD W++GVI+YILLCGYPPFYDE+D +LF QIL+A YEFDSP+WDDIS+SA
Sbjct: 193 LAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSA 252
Query: 261 KDFIRHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGSVSEQIRKNFARTHWKRAFNA 320
KDFIR+L+E+DP KR+TC+QA RH WI+GDTA +++I SVS QIRKNFA++ W++AFNA
Sbjct: 253 KDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNFAKSKWRQAFNA 312
Query: 321 TSFLRHIRKL 330
T+ +RH+RKL
Sbjct: 313 TAVVRHMRKL 322
>gi|23943850 calcium/calmodulin-dependent protein kinase ID isoform
2 [Homo sapiens]
Length = 385
Score = 457 bits (1177), Expect = e-129
Identities = 215/310 (69%), Positives = 269/310 (86%), Gaps = 1/310 (0%)
Query: 22 KKHTEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAV 81
KK EDI ++E +E LG+GAFSEVVLA+E+ + L A+KCIPKKAL+GKE+ +ENEIAV
Sbjct: 13 KKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAV 72
Query: 82 LRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAV 141
LR+I H NIVALED++ESP+HLYL M+LV+GGELFDRI+E+G YTEKDAS L+ QVL AV
Sbjct: 73 LRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAV 132
Query: 142 SYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQA-GNMLGTACGTPGYVAPEL 200
YLH +GIVHRDLKPENLLY + E+SKIM+SDFGLSK++ G+++ TACGTPGYVAPE+
Sbjct: 133 YYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEV 192
Query: 201 LEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESA 260
L QKPY KAVD W++GVI+YILLCGYPPFYDE+D +LF QIL+A YEFDSP+WDDIS+SA
Sbjct: 193 LAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSA 252
Query: 261 KDFIRHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGSVSEQIRKNFARTHWKRAFNA 320
KDFIR+L+E+DP KR+TC+QA RH WI+GDTA +++I SVS QIRKNFA++ W++AFNA
Sbjct: 253 KDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNFAKSKWRQAFNA 312
Query: 321 TSFLRHIRKL 330
T+ +RH+RKL
Sbjct: 313 TAVVRHMRKL 322
>gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo
sapiens]
Length = 476
Score = 410 bits (1053), Expect = e-114
Identities = 199/320 (62%), Positives = 251/320 (78%), Gaps = 1/320 (0%)
Query: 11 GRRPSGDMLLLKKHTEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRG 70
GR+ D KK T +I + E LGSGAFSEV L ++R + L ALKCI KK+
Sbjct: 2 GRKEEDDCSSWKKQTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCI-KKSPAF 60
Query: 71 KEALVENEIAVLRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDA 130
+++ +ENEIAVL++I H NIV LED++ES +H YL M+LV+GGELFDRI+ERG YTEKDA
Sbjct: 61 RDSSLENEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDA 120
Query: 131 SHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNMLGTAC 190
S ++ QVL AV YLH GIVHRDLKPENLLY TP E+SKIM++DFGLSK++ ++ TAC
Sbjct: 121 SLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTAC 180
Query: 191 GTPGYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDS 250
GTPGYVAPE+L QKPY KAVD W++GVI+YILLCGYPPFY+E++ +LF +I YEF+S
Sbjct: 181 GTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFES 240
Query: 251 PFWDDISESAKDFIRHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGSVSEQIRKNFA 310
PFWDDISESAKDFI HLLE+DP +R+TC++AL H WI G+TA RDI SVS QI+KNFA
Sbjct: 241 PFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWIDGNTALHRDIYPSVSLQIQKNFA 300
Query: 311 RTHWKRAFNATSFLRHIRKL 330
++ W++AFNA + + H+RKL
Sbjct: 301 KSKWRQAFNAAAVVHHMRKL 320
>gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo
sapiens]
Length = 473
Score = 278 bits (710), Expect = 7e-75
Identities = 149/332 (44%), Positives = 210/332 (63%), Gaps = 14/332 (4%)
Query: 28 ISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRISH 87
+S +E+ LG GA S V +++G+ ALK + K + +V EI VL R+SH
Sbjct: 42 LSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTV---DKKIVRTEIGVLLRLSH 98
Query: 88 PNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSL 147
PNI+ L+++ E+P+ + L +ELVTGGELFDRI+E+G Y+E+DA+ V Q+L AV+YLH
Sbjct: 99 PNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHEN 158
Query: 148 GIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNML-GTACGTPGYVAPELLEQKPY 206
GIVHRDLKPENLLYATP D+ + ++DFGLSKI +L T CGTPGY APE+L Y
Sbjct: 159 GIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAY 218
Query: 207 GKAVDVWALGVISYILLCGYPPFYDE-SDPELFSQILRASYEFDSPFWDDISESAKDFIR 265
G VD+W++G+I+YILLCG+ PFYDE D +F +IL Y F SP+WD++S +AKD +R
Sbjct: 219 GPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVR 278
Query: 266 HLLERDPQKRFTCQQALRHLWISGDTAFDRDILGSVSEQIRKNFARTHWKRAFNATSFLR 325
L+ DP+KR T QAL+H W++G A + + + +++++ AR K A A
Sbjct: 279 KLIVLDPKKRLTTFQALQHPWVTGKAA-NFVHMDTAQKKLQEFNARRKLKAAVKAVVASS 337
Query: 326 HIRKLGQIPEGEGASEQGMARHSHSGLRAGQP 357
+ G +S G + SH R P
Sbjct: 338 RL--------GSASSSHGSIQESHKASRDPSP 361
>gi|83776596 CaM kinase-like vesicle-associated [Homo sapiens]
Length = 501
Score = 271 bits (692), Expect = 9e-73
Identities = 134/310 (43%), Positives = 204/310 (65%), Gaps = 9/310 (2%)
Query: 27 DISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRIS 86
+++ Y++ + + + F E+ A+++ + L K K+ R +NEI +L+ +
Sbjct: 19 EVTDRYDLGQVIKTEEFCEIFRAKDKTTGKLHTCKKFQKRDGRKVRKAAKNEIGILKMVK 78
Query: 87 HPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHS 146
HPNI+ L DV + ++ +EL TG E+FD I+++G Y+E+D S++V QVL AV+YLHS
Sbjct: 79 HPNILQLVDVFVTRKEYFIFLELATGREVFDWILDQGYYSERDTSNVVRQVLEAVAYLHS 138
Query: 147 LGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNMLGTACGTPGYVAPELLEQKPY 206
L IVHR+LK ENL+Y ++SKI++SDF L+K++ G ++ CGTP Y+APE++ ++ Y
Sbjct: 139 LKIVHRNLKLENLVYYNRLKNSKIVISDFHLAKLENG-LIKEPCGTPEYLAPEVVGRQRY 197
Query: 207 GKAVDVWALGVISYILLCGYPPFYDE--------SDPELFSQILRASYEFDSPFWDDISE 258
G+ VD WA+GVI YILL G PPFY+E D LF +IL YEFDSP+WDDIS+
Sbjct: 198 GRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDSPYWDDISQ 257
Query: 259 SAKDFIRHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGSVSEQIRKNFARTHWKRAF 318
+AKD + L+E + +R T ++A+ H WISG+ A D++I V QI KNFAR WK+A
Sbjct: 258 AAKDLVTRLMEVEQDQRITAEEAISHEWISGNAASDKNIKDGVCAQIEKNFARAKWKKAV 317
Query: 319 NATSFLRHIR 328
T+ ++ +R
Sbjct: 318 RVTTLMKRLR 327
>gi|27901803 protein serine kinase H1 [Homo sapiens]
Length = 424
Score = 258 bits (658), Expect = 8e-69
Identities = 133/285 (46%), Positives = 186/285 (65%), Gaps = 6/285 (2%)
Query: 28 ISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRISH 87
+++ Y+I+ +G G+FS VV + R + A+K I K G+E + E+E+ VLRR+ H
Sbjct: 94 VTAKYDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGRE-VCESELRVLRRVRH 152
Query: 88 PNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSL 147
NI+ L +V E+ +Y+ MEL TGGELFDRI+ +GS+TE+DA+ ++ VL V YLH+L
Sbjct: 153 ANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLHAL 212
Query: 148 GIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGN---MLGTACGTPGYVAPELLEQK 204
GI HRDLKPENLLY P DSKI+++DFGL+ + ++ T CGTP Y+APE+L +K
Sbjct: 213 GITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLVRK 272
Query: 205 PYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFI 264
PY +VD+WALGVI+YILL G PF D++ L+ QILR Y + W +S AKDFI
Sbjct: 273 PYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKDFI 332
Query: 265 RHLLERDPQKRFTCQQALRHLWISGDTAFD--RDILGSVSEQIRK 307
LL DP R T QALRH W+ A +++ S+S+ + K
Sbjct: 333 DRLLTVDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQNLLK 377
>gi|4758128 doublecortin-like kinase 1 [Homo sapiens]
Length = 729
Score = 254 bits (650), Expect = 6e-68
Identities = 133/285 (46%), Positives = 184/285 (64%), Gaps = 4/285 (1%)
Query: 28 ISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRISH 87
I+ Y++ +G G F+ V ER +A ALK I K RGKE +++NE+++LRR+ H
Sbjct: 386 ITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKH 445
Query: 88 PNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSL 147
PNIV L + + P+ LYL MELV GG+LFD I YTE+DAS ++ + A+ YLHSL
Sbjct: 446 PNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSL 505
Query: 148 GIVHRDLKPENLLYATPFEDSK-IMVSDFGLSKIQAGNMLGTACGTPGYVAPELLEQKPY 206
IVHRD+KPENLL + SK + + DFGL+ I G L T CGTP YVAPE++ + Y
Sbjct: 506 NIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDG-PLYTVCGTPTYVAPEIIAETGY 564
Query: 207 GKAVDVWALGVISYILLCGYPPFYDESDPE--LFSQILRASYEFDSPFWDDISESAKDFI 264
G VD+WA GVI+YILLCG+PPF D + LF QIL +F SP+WD++S+SAK+ I
Sbjct: 565 GLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELI 624
Query: 265 RHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGSVSEQIRKNF 309
+L D +RF+ Q L H W++ D + + SV+ +I+K+F
Sbjct: 625 TMMLLVDVDQRFSAVQVLEHPWVNDDGLPENEHQLSVAGKIKKHF 669
>gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens]
Length = 765
Score = 245 bits (626), Expect = 4e-65
Identities = 131/305 (42%), Positives = 189/305 (61%), Gaps = 12/305 (3%)
Query: 8 GLAGRRPSGDMLLLKKHTEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKA 67
G+ G R S LL+K Y+I + +G G F+ V +R + ALK I K
Sbjct: 377 GVNGNRCSESSTLLEK--------YKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAK 428
Query: 68 LRGKEALVENEIAVLRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTE 127
GKE L+ENE+++LRR+ HPNI+ L + E+ + L+L MELV GG+LFD I YTE
Sbjct: 429 CCGKEHLIENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTE 488
Query: 128 KDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYAT-PFEDSKIMVSDFGLSKIQAGNML 186
+D S +V + A+ YLH L IVHRD+KPENLL P + + DFGL+ + G L
Sbjct: 489 RDGSAMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEG-PL 547
Query: 187 GTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESD--PELFSQILRA 244
T CGTP YVAPE++ + YG VD+WA GVI+YILLCG+PPF E++ +LF QIL
Sbjct: 548 YTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAG 607
Query: 245 SYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGSVSEQ 304
EF +P+WD+I++SAK+ I +L+ + + R T Q L H W+S D + + ++ V+ +
Sbjct: 608 KLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGK 667
Query: 305 IRKNF 309
++++F
Sbjct: 668 LKQHF 672
>gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens]
Length = 766
Score = 245 bits (626), Expect = 4e-65
Identities = 131/305 (42%), Positives = 189/305 (61%), Gaps = 12/305 (3%)
Query: 8 GLAGRRPSGDMLLLKKHTEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKA 67
G+ G R S LL+K Y+I + +G G F+ V +R + ALK I K
Sbjct: 378 GVNGNRCSESSTLLEK--------YKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAK 429
Query: 68 LRGKEALVENEIAVLRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTE 127
GKE L+ENE+++LRR+ HPNI+ L + E+ + L+L MELV GG+LFD I YTE
Sbjct: 430 CCGKEHLIENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTE 489
Query: 128 KDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYAT-PFEDSKIMVSDFGLSKIQAGNML 186
+D S +V + A+ YLH L IVHRD+KPENLL P + + DFGL+ + G L
Sbjct: 490 RDGSAMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEG-PL 548
Query: 187 GTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESD--PELFSQILRA 244
T CGTP YVAPE++ + YG VD+WA GVI+YILLCG+PPF E++ +LF QIL
Sbjct: 549 YTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAG 608
Query: 245 SYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGSVSEQ 304
EF +P+WD+I++SAK+ I +L+ + + R T Q L H W+S D + + ++ V+ +
Sbjct: 609 KLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGK 668
Query: 305 IRKNF 309
++++F
Sbjct: 669 LKQHF 673
>gi|14916455 protein serine kinase H2 [Homo sapiens]
Length = 385
Score = 235 bits (600), Expect = 4e-62
Identities = 126/289 (43%), Positives = 183/289 (63%), Gaps = 10/289 (3%)
Query: 32 YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRISHPNIV 91
Y+I+ +G+G+FS VV +++ + A+K + + G+EA V +E++VLRR+SH IV
Sbjct: 63 YDIKALIGTGSFSRVVRVEQKTTKKPFAIKVMETREREGREACV-SELSVLRRVSHRYIV 121
Query: 92 ALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIVH 151
L ++ E+ +Y+ MEL TGGELFDR++ +GS+TE+DA ++ V + YLH+L I H
Sbjct: 122 QLMEIFETEDQVYMVMELATGGELFDRLIAQGSFTERDAVRILQMVADGIRYLHALQITH 181
Query: 152 RDLKPENLLYATPFEDSKIMVSDFGLS---KIQAGNMLGTACGTPGYVAPELLEQKPYGK 208
R+LKPENLLY P E+SKI+++DFGL+ K + T CGTP Y+APE+L +KPY
Sbjct: 182 RNLKPENLLYYHPGEESKILITDFGLAYSGKKSGDWTMKTLCGTPEYIAPEVLLRKPYTS 241
Query: 209 AVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHLL 268
AVD+WALGVI+Y LL G+ PF DES L+ +IL+ Y + W IS AKDFI LL
Sbjct: 242 AVDMWALGVITYALLSGFLPFDDESQTRLYRKILKGKYNYTGEPWPSISHLAKDFIDKLL 301
Query: 269 ERDPQKRFTCQQALRHLWISGDTAFDRDILGSVSEQIRKNFARTHWKRA 317
+ R + QAL H W+ A GS + +++ +R +RA
Sbjct: 302 ILEAGHRMSAGQALDHPWVITMAA------GSSMKNLQRAISRNLMQRA 344
>gi|25952118 calcium/calmodulin-dependent protein kinase II alpha
isoform 2 [Homo sapiens]
Length = 478
Score = 230 bits (586), Expect = 2e-60
Identities = 122/261 (46%), Positives = 162/261 (62%), Gaps = 5/261 (1%)
Query: 32 YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKE-ALVENEIAVLRRISHPNI 90
Y++ E LG GAFS V + + A K I K L ++ +E E + R + HPNI
Sbjct: 13 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 72
Query: 91 VALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIV 150
V L D H YL +LVTGGELF+ I+ R Y+E DASH + Q+L AV + H +G+V
Sbjct: 73 VRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV 132
Query: 151 HRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNM---LGTACGTPGYVAPELLEQKPYG 207
HRDLKPENLL A+ + + + ++DFGL+ G G A GTPGY++PE+L + PYG
Sbjct: 133 HRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFA-GTPGYLSPEVLRKDPYG 191
Query: 208 KAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHL 267
K VD+WA GVI YILL GYPPF+DE L+ QI +Y+F SP WD ++ AKD I +
Sbjct: 192 KPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKM 251
Query: 268 LERDPQKRFTCQQALRHLWIS 288
L +P KR T +AL+H WIS
Sbjct: 252 LTINPSKRITAAEALKHPWIS 272
>gi|25952114 calcium/calmodulin-dependent protein kinase II alpha
isoform 1 [Homo sapiens]
Length = 489
Score = 230 bits (586), Expect = 2e-60
Identities = 122/261 (46%), Positives = 162/261 (62%), Gaps = 5/261 (1%)
Query: 32 YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKE-ALVENEIAVLRRISHPNI 90
Y++ E LG GAFS V + + A K I K L ++ +E E + R + HPNI
Sbjct: 13 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 72
Query: 91 VALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIV 150
V L D H YL +LVTGGELF+ I+ R Y+E DASH + Q+L AV + H +G+V
Sbjct: 73 VRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV 132
Query: 151 HRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNM---LGTACGTPGYVAPELLEQKPYG 207
HRDLKPENLL A+ + + + ++DFGL+ G G A GTPGY++PE+L + PYG
Sbjct: 133 HRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFA-GTPGYLSPEVLRKDPYG 191
Query: 208 KAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHL 267
K VD+WA GVI YILL GYPPF+DE L+ QI +Y+F SP WD ++ AKD I +
Sbjct: 192 KPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKM 251
Query: 268 LERDPQKRFTCQQALRHLWIS 288
L +P KR T +AL+H WIS
Sbjct: 252 LTINPSKRITAAEALKHPWIS 272
>gi|26667196 calcium/calmodulin-dependent protein kinase II gamma
isoform 2 [Homo sapiens]
Length = 527
Score = 229 bits (583), Expect = 4e-60
Identities = 135/329 (41%), Positives = 184/329 (55%), Gaps = 9/329 (2%)
Query: 32 YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKE-ALVENEIAVLRRISHPNI 90
Y++ E LG GAFS V ++ S A K I K L ++ +E E + R + HPNI
Sbjct: 14 YQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 73
Query: 91 VALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIV 150
V L D YL +LVTGGELF+ I+ R Y+E DASH + Q+L +V+++H IV
Sbjct: 74 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIV 133
Query: 151 HRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNM---LGTACGTPGYVAPELLEQKPYG 207
HRDLKPENLL A+ + + + ++DFGL+ G G A GTPGY++PE+L + PYG
Sbjct: 134 HRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFA-GTPGYLSPEVLRKDPYG 192
Query: 208 KAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHL 267
K VD+WA GVI YILL GYPPF+DE +L+ QI +Y+F SP WD ++ AK+ I +
Sbjct: 193 KPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQM 252
Query: 268 LERDPQKRFTCQQALRHLWI-SGDTAFDRDILGSVSEQIRKNFARTHWKRAFNATSFLRH 326
L +P KR T QAL+H W+ T E +RK AR K A T +
Sbjct: 253 LTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSR 312
Query: 327 IRKLGQ---IPEGEGASEQGMARHSHSGL 352
+G+ P AS G+A + L
Sbjct: 313 NFSVGRQSSAPASPAASAAGLAGQAAKSL 341
>gi|149589021 doublecortin-like kinase 3 [Homo sapiens]
Length = 648
Score = 226 bits (576), Expect = 2e-59
Identities = 117/264 (44%), Positives = 168/264 (63%), Gaps = 4/264 (1%)
Query: 27 DISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRIS 86
++ YE +G G F+ V + R + A+K I K L+GKE +V++EI +++ +S
Sbjct: 351 NVEKHYETGRVIGDGNFAVVKECRHRETRQAYAMKIIDKSRLKGKEDMVDSEILIIQSLS 410
Query: 87 HPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHS 146
HPNIV L +V+E+ +YL +E V GG+LFD I+E + E DA+ ++ + A+ ++H
Sbjct: 411 HPNIVKLHEVYETDMEIYLILEYVQGGDLFDAIIESVKFPEPDAALMIMDLCKALVHMHD 470
Query: 147 LGIVHRDLKPENLLYATPFEDS-KIMVSDFGLSKIQAGNMLGTACGTPGYVAPELLEQKP 205
IVHRDLKPENLL + S + ++DFGL+K + T CGTP YVAPE+L +K
Sbjct: 471 KSIVHRDLKPENLLVQRNEDKSTTLKLADFGLAK-HVVRPIFTVCGTPTYVAPEILSEKG 529
Query: 206 YGKAVDVWALGVISYILLCGYPPFY--DESDPELFSQILRASYEFDSPFWDDISESAKDF 263
YG VD+WA GVI YILLCG+PPF + ELF+ I +EF P+WD+IS++AKD
Sbjct: 530 YGLEVDMWAAGVILYILLCGFPPFRSPERDQDELFNIIQLGHFEFLPPYWDNISDAAKDL 589
Query: 264 IRHLLERDPQKRFTCQQALRHLWI 287
+ LL DP+KR+T Q L+H WI
Sbjct: 590 VSRLLVVDPKKRYTAHQVLQHPWI 613
>gi|26667199 calcium/calmodulin-dependent protein kinase II gamma
isoform 3 [Homo sapiens]
Length = 518
Score = 226 bits (575), Expect = 3e-59
Identities = 119/260 (45%), Positives = 162/260 (62%), Gaps = 5/260 (1%)
Query: 32 YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKE-ALVENEIAVLRRISHPNI 90
Y++ E LG GAFS V ++ S A K I K L ++ +E E + R + HPNI
Sbjct: 14 YQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 73
Query: 91 VALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIV 150
V L D YL +LVTGGELF+ I+ R Y+E DASH + Q+L +V+++H IV
Sbjct: 74 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIV 133
Query: 151 HRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNM---LGTACGTPGYVAPELLEQKPYG 207
HRDLKPENLL A+ + + + ++DFGL+ G G A GTPGY++PE+L + PYG
Sbjct: 134 HRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFA-GTPGYLSPEVLRKDPYG 192
Query: 208 KAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHL 267
K VD+WA GVI YILL GYPPF+DE +L+ QI +Y+F SP WD ++ AK+ I +
Sbjct: 193 KPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQM 252
Query: 268 LERDPQKRFTCQQALRHLWI 287
L +P KR T QAL+H W+
Sbjct: 253 LTINPAKRITADQALKHPWV 272
>gi|26667191 calcium/calmodulin-dependent protein kinase II gamma
isoform 4 [Homo sapiens]
Length = 495
Score = 226 bits (575), Expect = 3e-59
Identities = 119/260 (45%), Positives = 162/260 (62%), Gaps = 5/260 (1%)
Query: 32 YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKE-ALVENEIAVLRRISHPNI 90
Y++ E LG GAFS V ++ S A K I K L ++ +E E + R + HPNI
Sbjct: 14 YQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 73
Query: 91 VALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIV 150
V L D YL +LVTGGELF+ I+ R Y+E DASH + Q+L +V+++H IV
Sbjct: 74 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIV 133
Query: 151 HRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNM---LGTACGTPGYVAPELLEQKPYG 207
HRDLKPENLL A+ + + + ++DFGL+ G G A GTPGY++PE+L + PYG
Sbjct: 134 HRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFA-GTPGYLSPEVLRKDPYG 192
Query: 208 KAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHL 267
K VD+WA GVI YILL GYPPF+DE +L+ QI +Y+F SP WD ++ AK+ I +
Sbjct: 193 KPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQM 252
Query: 268 LERDPQKRFTCQQALRHLWI 287
L +P KR T QAL+H W+
Sbjct: 253 LTINPAKRITADQALKHPWV 272
>gi|26667211 calcium/calmodulin-dependent protein kinase II gamma
isoform 6 [Homo sapiens]
Length = 504
Score = 226 bits (575), Expect = 3e-59
Identities = 119/260 (45%), Positives = 162/260 (62%), Gaps = 5/260 (1%)
Query: 32 YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKE-ALVENEIAVLRRISHPNI 90
Y++ E LG GAFS V ++ S A K I K L ++ +E E + R + HPNI
Sbjct: 14 YQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 73
Query: 91 VALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIV 150
V L D YL +LVTGGELF+ I+ R Y+E DASH + Q+L +V+++H IV
Sbjct: 74 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIV 133
Query: 151 HRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNM---LGTACGTPGYVAPELLEQKPYG 207
HRDLKPENLL A+ + + + ++DFGL+ G G A GTPGY++PE+L + PYG
Sbjct: 134 HRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFA-GTPGYLSPEVLRKDPYG 192
Query: 208 KAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHL 267
K VD+WA GVI YILL GYPPF+DE +L+ QI +Y+F SP WD ++ AK+ I +
Sbjct: 193 KPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQM 252
Query: 268 LERDPQKRFTCQQALRHLWI 287
L +P KR T QAL+H W+
Sbjct: 253 LTINPAKRITADQALKHPWV 272
>gi|26667203 calcium/calmodulin-dependent protein kinase II gamma
isoform 1 [Homo sapiens]
Length = 556
Score = 226 bits (575), Expect = 3e-59
Identities = 119/260 (45%), Positives = 162/260 (62%), Gaps = 5/260 (1%)
Query: 32 YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKE-ALVENEIAVLRRISHPNI 90
Y++ E LG GAFS V ++ S A K I K L ++ +E E + R + HPNI
Sbjct: 14 YQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 73
Query: 91 VALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIV 150
V L D YL +LVTGGELF+ I+ R Y+E DASH + Q+L +V+++H IV
Sbjct: 74 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIV 133
Query: 151 HRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNM---LGTACGTPGYVAPELLEQKPYG 207
HRDLKPENLL A+ + + + ++DFGL+ G G A GTPGY++PE+L + PYG
Sbjct: 134 HRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFA-GTPGYLSPEVLRKDPYG 192
Query: 208 KAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHL 267
K VD+WA GVI YILL GYPPF+DE +L+ QI +Y+F SP WD ++ AK+ I +
Sbjct: 193 KPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQM 252
Query: 268 LERDPQKRFTCQQALRHLWI 287
L +P KR T QAL+H W+
Sbjct: 253 LTINPAKRITADQALKHPWV 272
>gi|212549756 calcium/calmodulin-dependent protein kinase II delta
isoform 4 [Homo sapiens]
Length = 489
Score = 224 bits (571), Expect = 9e-59
Identities = 120/260 (46%), Positives = 161/260 (61%), Gaps = 5/260 (1%)
Query: 32 YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKE-ALVENEIAVLRRISHPNI 90
Y++ E LG GAFS V + + A K I K L ++ +E E + R + HPNI
Sbjct: 14 YQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 73
Query: 91 VALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIV 150
V L D YL +LVTGGELF+ I+ R Y+E DASH + Q+L +V++ H GIV
Sbjct: 74 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIV 133
Query: 151 HRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNM---LGTACGTPGYVAPELLEQKPYG 207
HRDLKPENLL A+ + + + ++DFGL+ G+ G A GTPGY++PE+L + PYG
Sbjct: 134 HRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFA-GTPGYLSPEVLRKDPYG 192
Query: 208 KAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHL 267
K VD+WA GVI YILL GYPPF+DE L+ QI +Y+F SP WD ++ AKD I +
Sbjct: 193 KPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKM 252
Query: 268 LERDPQKRFTCQQALRHLWI 287
L +P KR T +AL+H WI
Sbjct: 253 LTINPAKRITASEALKHPWI 272
>gi|26667183 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 224 bits (571), Expect = 9e-59
Identities = 120/260 (46%), Positives = 161/260 (61%), Gaps = 5/260 (1%)
Query: 32 YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKE-ALVENEIAVLRRISHPNI 90
Y++ E LG GAFS V + + A K I K L ++ +E E + R + HPNI
Sbjct: 14 YQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 73
Query: 91 VALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIV 150
V L D YL +LVTGGELF+ I+ R Y+E DASH + Q+L +V++ H GIV
Sbjct: 74 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIV 133
Query: 151 HRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNM---LGTACGTPGYVAPELLEQKPYG 207
HRDLKPENLL A+ + + + ++DFGL+ G+ G A GTPGY++PE+L + PYG
Sbjct: 134 HRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFA-GTPGYLSPEVLRKDPYG 192
Query: 208 KAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHL 267
K VD+WA GVI YILL GYPPF+DE L+ QI +Y+F SP WD ++ AKD I +
Sbjct: 193 KPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKM 252
Query: 268 LERDPQKRFTCQQALRHLWI 287
L +P KR T +AL+H WI
Sbjct: 253 LTINPAKRITASEALKHPWI 272
>gi|212549753 calcium/calmodulin-dependent protein kinase II delta
isoform 5 [Homo sapiens]
Length = 492
Score = 224 bits (571), Expect = 9e-59
Identities = 120/260 (46%), Positives = 161/260 (61%), Gaps = 5/260 (1%)
Query: 32 YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKE-ALVENEIAVLRRISHPNI 90
Y++ E LG GAFS V + + A K I K L ++ +E E + R + HPNI
Sbjct: 14 YQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 73
Query: 91 VALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIV 150
V L D YL +LVTGGELF+ I+ R Y+E DASH + Q+L +V++ H GIV
Sbjct: 74 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIV 133
Query: 151 HRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNM---LGTACGTPGYVAPELLEQKPYG 207
HRDLKPENLL A+ + + + ++DFGL+ G+ G A GTPGY++PE+L + PYG
Sbjct: 134 HRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFA-GTPGYLSPEVLRKDPYG 192
Query: 208 KAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHL 267
K VD+WA GVI YILL GYPPF+DE L+ QI +Y+F SP WD ++ AKD I +
Sbjct: 193 KPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKM 252
Query: 268 LERDPQKRFTCQQALRHLWI 287
L +P KR T +AL+H WI
Sbjct: 253 LTINPAKRITASEALKHPWI 272
>gi|26667186 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 224 bits (571), Expect = 9e-59
Identities = 120/260 (46%), Positives = 161/260 (61%), Gaps = 5/260 (1%)
Query: 32 YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKE-ALVENEIAVLRRISHPNI 90
Y++ E LG GAFS V + + A K I K L ++ +E E + R + HPNI
Sbjct: 14 YQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 73
Query: 91 VALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIV 150
V L D YL +LVTGGELF+ I+ R Y+E DASH + Q+L +V++ H GIV
Sbjct: 74 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIV 133
Query: 151 HRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNM---LGTACGTPGYVAPELLEQKPYG 207
HRDLKPENLL A+ + + + ++DFGL+ G+ G A GTPGY++PE+L + PYG
Sbjct: 134 HRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFA-GTPGYLSPEVLRKDPYG 192
Query: 208 KAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHL 267
K VD+WA GVI YILL GYPPF+DE L+ QI +Y+F SP WD ++ AKD I +
Sbjct: 193 KPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKM 252
Query: 268 LERDPQKRFTCQQALRHLWI 287
L +P KR T +AL+H WI
Sbjct: 253 LTINPAKRITASEALKHPWI 272
>gi|26667189 calcium/calmodulin-dependent protein kinase II delta
isoform 2 [Homo sapiens]
Length = 478
Score = 224 bits (571), Expect = 9e-59
Identities = 120/260 (46%), Positives = 161/260 (61%), Gaps = 5/260 (1%)
Query: 32 YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKE-ALVENEIAVLRRISHPNI 90
Y++ E LG GAFS V + + A K I K L ++ +E E + R + HPNI
Sbjct: 14 YQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 73
Query: 91 VALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIV 150
V L D YL +LVTGGELF+ I+ R Y+E DASH + Q+L +V++ H GIV
Sbjct: 74 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIV 133
Query: 151 HRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNM---LGTACGTPGYVAPELLEQKPYG 207
HRDLKPENLL A+ + + + ++DFGL+ G+ G A GTPGY++PE+L + PYG
Sbjct: 134 HRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFA-GTPGYLSPEVLRKDPYG 192
Query: 208 KAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHL 267
K VD+WA GVI YILL GYPPF+DE L+ QI +Y+F SP WD ++ AKD I +
Sbjct: 193 KPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKM 252
Query: 268 LERDPQKRFTCQQALRHLWI 287
L +P KR T +AL+H WI
Sbjct: 253 LTINPAKRITASEALKHPWI 272
>gi|26667180 calcium/calmodulin-dependent protein kinase II delta
isoform 3 [Homo sapiens]
Length = 499
Score = 224 bits (571), Expect = 9e-59
Identities = 120/260 (46%), Positives = 161/260 (61%), Gaps = 5/260 (1%)
Query: 32 YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKE-ALVENEIAVLRRISHPNI 90
Y++ E LG GAFS V + + A K I K L ++ +E E + R + HPNI
Sbjct: 14 YQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 73
Query: 91 VALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIV 150
V L D YL +LVTGGELF+ I+ R Y+E DASH + Q+L +V++ H GIV
Sbjct: 74 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIV 133
Query: 151 HRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNM---LGTACGTPGYVAPELLEQKPYG 207
HRDLKPENLL A+ + + + ++DFGL+ G+ G A GTPGY++PE+L + PYG
Sbjct: 134 HRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFA-GTPGYLSPEVLRKDPYG 192
Query: 208 KAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHL 267
K VD+WA GVI YILL GYPPF+DE L+ QI +Y+F SP WD ++ AKD I +
Sbjct: 193 KPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKM 252
Query: 268 LERDPQKRFTCQQALRHLWI 287
L +P KR T +AL+H WI
Sbjct: 253 LTINPAKRITASEALKHPWI 272
>gi|26051204 calcium/calmodulin-dependent protein kinase II beta
isoform 1 [Homo sapiens]
Length = 666
Score = 221 bits (564), Expect = 6e-58
Identities = 116/260 (44%), Positives = 162/260 (62%), Gaps = 5/260 (1%)
Query: 32 YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKE-ALVENEIAVLRRISHPNI 90
Y++ E +G GAFS V + + H A K I K L ++ +E E + R + H NI
Sbjct: 14 YQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNI 73
Query: 91 VALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIV 150
V L D YL +LVTGGELF+ I+ R Y+E DASH + Q+L AV + H +G+V
Sbjct: 74 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV 133
Query: 151 HRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNM---LGTACGTPGYVAPELLEQKPYG 207
HRDLKPENLL A+ + + + ++DFGL+ G+ G A GTPGY++PE+L ++ YG
Sbjct: 134 HRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFA-GTPGYLSPEVLRKEAYG 192
Query: 208 KAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHL 267
K VD+WA GVI YILL GYPPF+DE +L+ QI +Y+F SP WD ++ AK+ I +
Sbjct: 193 KPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQM 252
Query: 268 LERDPQKRFTCQQALRHLWI 287
L +P KR T +AL+H W+
Sbjct: 253 LTINPAKRITAHEALKHPWV 272
>gi|26051210 calcium/calmodulin-dependent protein kinase II beta
isoform 4 [Homo sapiens]
Length = 517
Score = 221 bits (564), Expect = 6e-58
Identities = 116/260 (44%), Positives = 162/260 (62%), Gaps = 5/260 (1%)
Query: 32 YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKE-ALVENEIAVLRRISHPNI 90
Y++ E +G GAFS V + + H A K I K L ++ +E E + R + H NI
Sbjct: 14 YQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNI 73
Query: 91 VALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIV 150
V L D YL +LVTGGELF+ I+ R Y+E DASH + Q+L AV + H +G+V
Sbjct: 74 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV 133
Query: 151 HRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNM---LGTACGTPGYVAPELLEQKPYG 207
HRDLKPENLL A+ + + + ++DFGL+ G+ G A GTPGY++PE+L ++ YG
Sbjct: 134 HRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFA-GTPGYLSPEVLRKEAYG 192
Query: 208 KAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHL 267
K VD+WA GVI YILL GYPPF+DE +L+ QI +Y+F SP WD ++ AK+ I +
Sbjct: 193 KPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQM 252
Query: 268 LERDPQKRFTCQQALRHLWI 287
L +P KR T +AL+H W+
Sbjct: 253 LTINPAKRITAHEALKHPWV 272
>gi|26051214 calcium/calmodulin-dependent protein kinase II beta
isoform 6 [Homo sapiens]
Length = 492
Score = 221 bits (564), Expect = 6e-58
Identities = 116/260 (44%), Positives = 162/260 (62%), Gaps = 5/260 (1%)
Query: 32 YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKE-ALVENEIAVLRRISHPNI 90
Y++ E +G GAFS V + + H A K I K L ++ +E E + R + H NI
Sbjct: 14 YQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNI 73
Query: 91 VALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIV 150
V L D YL +LVTGGELF+ I+ R Y+E DASH + Q+L AV + H +G+V
Sbjct: 74 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV 133
Query: 151 HRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNM---LGTACGTPGYVAPELLEQKPYG 207
HRDLKPENLL A+ + + + ++DFGL+ G+ G A GTPGY++PE+L ++ YG
Sbjct: 134 HRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFA-GTPGYLSPEVLRKEAYG 192
Query: 208 KAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHL 267
K VD+WA GVI YILL GYPPF+DE +L+ QI +Y+F SP WD ++ AK+ I +
Sbjct: 193 KPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQM 252
Query: 268 LERDPQKRFTCQQALRHLWI 287
L +P KR T +AL+H W+
Sbjct: 253 LTINPAKRITAHEALKHPWV 272
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,681,181
Number of Sequences: 37866
Number of extensions: 658024
Number of successful extensions: 3841
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 591
Number of HSP's successfully gapped in prelim test: 208
Number of HSP's that attempted gapping in prelim test: 1459
Number of HSP's gapped (non-prelim): 948
length of query: 360
length of database: 18,247,518
effective HSP length: 103
effective length of query: 257
effective length of database: 14,347,320
effective search space: 3687261240
effective search space used: 3687261240
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.