BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|209364619 pregnancy upregulated non-ubiquitously expressed CaM kinase isoform a [Homo sapiens] (426 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|209364619 pregnancy upregulated non-ubiquitously expressed Ca... 867 0.0 gi|209364621 pregnancy upregulated non-ubiquitously expressed Ca... 696 0.0 gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo s... 458 e-129 gi|9966875 calcium/calmodulin-dependent protein kinase ID isofor... 457 e-129 gi|23943850 calcium/calmodulin-dependent protein kinase ID isofo... 457 e-129 gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo... 406 e-113 gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo ... 278 9e-75 gi|83776596 CaM kinase-like vesicle-associated [Homo sapiens] 271 1e-72 gi|27901803 protein serine kinase H1 [Homo sapiens] 258 9e-69 gi|4758128 doublecortin-like kinase 1 [Homo sapiens] 254 8e-68 gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens] 245 5e-65 gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens] 243 3e-64 gi|14916455 protein serine kinase H2 [Homo sapiens] 243 3e-64 gi|25952118 calcium/calmodulin-dependent protein kinase II alpha... 230 2e-60 gi|25952114 calcium/calmodulin-dependent protein kinase II alpha... 230 2e-60 gi|26667196 calcium/calmodulin-dependent protein kinase II gamma... 229 5e-60 gi|149589021 doublecortin-like kinase 3 [Homo sapiens] 226 3e-59 gi|26667199 calcium/calmodulin-dependent protein kinase II gamma... 226 4e-59 gi|26667191 calcium/calmodulin-dependent protein kinase II gamma... 226 4e-59 gi|26667211 calcium/calmodulin-dependent protein kinase II gamma... 226 4e-59 gi|26667203 calcium/calmodulin-dependent protein kinase II gamma... 226 4e-59 gi|212549756 calcium/calmodulin-dependent protein kinase II delt... 224 1e-58 gi|26667183 calcium/calmodulin-dependent protein kinase II delta... 224 1e-58 gi|212549753 calcium/calmodulin-dependent protein kinase II delt... 224 1e-58 gi|26667186 calcium/calmodulin-dependent protein kinase II delta... 224 1e-58 gi|26667189 calcium/calmodulin-dependent protein kinase II delta... 224 1e-58 gi|26667180 calcium/calmodulin-dependent protein kinase II delta... 224 1e-58 gi|26051204 calcium/calmodulin-dependent protein kinase II beta ... 221 7e-58 gi|26051210 calcium/calmodulin-dependent protein kinase II beta ... 221 7e-58 gi|26051214 calcium/calmodulin-dependent protein kinase II beta ... 221 7e-58 >gi|209364619 pregnancy upregulated non-ubiquitously expressed CaM kinase isoform a [Homo sapiens] Length = 426 Score = 867 bits (2241), Expect = 0.0 Identities = 426/426 (100%), Positives = 426/426 (100%) Query: 1 MEAAFGQVAGSACPRRGGEGRDWKAESLADLWPKSSPGDSHRWCKGPGAGPAGPQLREAA 60 MEAAFGQVAGSACPRRGGEGRDWKAESLADLWPKSSPGDSHRWCKGPGAGPAGPQLREAA Sbjct: 1 MEAAFGQVAGSACPRRGGEGRDWKAESLADLWPKSSPGDSHRWCKGPGAGPAGPQLREAA 60 Query: 61 RASSGLGGGGRHPSRIPAIALQDMLLLKKHTEDISSVYEIRERLGSGAFSEVVLAQERGS 120 RASSGLGGGGRHPSRIPAIALQDMLLLKKHTEDISSVYEIRERLGSGAFSEVVLAQERGS Sbjct: 61 RASSGLGGGGRHPSRIPAIALQDMLLLKKHTEDISSVYEIRERLGSGAFSEVVLAQERGS 120 Query: 121 AHLVALKCIPKKALRGKEALVENEIAVLRRISHPNIVALEDVHESPSHLYLAMELVTGGE 180 AHLVALKCIPKKALRGKEALVENEIAVLRRISHPNIVALEDVHESPSHLYLAMELVTGGE Sbjct: 121 AHLVALKCIPKKALRGKEALVENEIAVLRRISHPNIVALEDVHESPSHLYLAMELVTGGE 180 Query: 181 LFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSD 240 LFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSD Sbjct: 181 LFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSD 240 Query: 241 FGLSKIQAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESD 300 FGLSKIQAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESD Sbjct: 241 FGLSKIQAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESD 300 Query: 301 PELFSQILRASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALRHLWISGDTAFD 360 PELFSQILRASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALRHLWISGDTAFD Sbjct: 301 PELFSQILRASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALRHLWISGDTAFD 360 Query: 361 RDILGSVSEQIRKNFARTHWKRAFNATSFLRHIRKLGQIPEGEGASEQGMARHSHSGLRA 420 RDILGSVSEQIRKNFARTHWKRAFNATSFLRHIRKLGQIPEGEGASEQGMARHSHSGLRA Sbjct: 361 RDILGSVSEQIRKNFARTHWKRAFNATSFLRHIRKLGQIPEGEGASEQGMARHSHSGLRA 420 Query: 421 GQPPKW 426 GQPPKW Sbjct: 421 GQPPKW 426 >gi|209364621 pregnancy upregulated non-ubiquitously expressed CaM kinase isoform b [Homo sapiens] Length = 360 Score = 696 bits (1797), Expect = 0.0 Identities = 349/360 (96%), Positives = 349/360 (96%), Gaps = 7/360 (1%) Query: 67 GGGGRHPSRIPAIALQDMLLLKKHTEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVAL 126 G GR PS DMLLLKKHTEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVAL Sbjct: 8 GLAGRRPSG-------DMLLLKKHTEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVAL 60 Query: 127 KCIPKKALRGKEALVENEIAVLRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIM 186 KCIPKKALRGKEALVENEIAVLRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIM Sbjct: 61 KCIPKKALRGKEALVENEIAVLRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIM 120 Query: 187 ERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKI 246 ERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKI Sbjct: 121 ERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKI 180 Query: 247 QAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQ 306 QAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQ Sbjct: 181 QAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQ 240 Query: 307 ILRASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGS 366 ILRASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGS Sbjct: 241 ILRASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGS 300 Query: 367 VSEQIRKNFARTHWKRAFNATSFLRHIRKLGQIPEGEGASEQGMARHSHSGLRAGQPPKW 426 VSEQIRKNFARTHWKRAFNATSFLRHIRKLGQIPEGEGASEQGMARHSHSGLRAGQPPKW Sbjct: 301 VSEQIRKNFARTHWKRAFNATSFLRHIRKLGQIPEGEGASEQGMARHSHSGLRAGQPPKW 360 >gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo sapiens] Length = 370 Score = 458 bits (1179), Expect = e-129 Identities = 219/319 (68%), Positives = 272/319 (85%), Gaps = 3/319 (0%) Query: 89 KHTEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVL 148 K EDI +Y+ R+ LG+GAFSEV+LA+++ + LVA+KCI K+AL GKE +ENEIAVL Sbjct: 11 KQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVL 70 Query: 149 RRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVS 208 +I HPNIVAL+D++ES HLYL M+LV+GGELFDRI+E+G YTE+DAS L+ QVL AV Sbjct: 71 HKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVK 130 Query: 209 YLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQ-AGNMLGTACGTPGYVAPELL 267 YLH LGIVHRDLKPENLLY + EDSKIM+SDFGLSK++ G++L TACGTPGYVAPE+L Sbjct: 131 YLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVL 190 Query: 268 EQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAK 327 QKPY KAVD W++GVI+YILLCGYPPFYDE+D +LF QIL+A YEFDSP+WDDIS+SAK Sbjct: 191 AQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAK 250 Query: 328 DFIRHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGSVSEQIRKNFARTHWKRAFNAT 387 DFIRHL+E+DP+KRFTC+QAL+H WI+GDTA D++I SVSEQI+KNFA++ WK+AFNAT Sbjct: 251 DFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNFAKSKWKQAFNAT 310 Query: 388 SFLRHIRK--LGQIPEGEG 404 + +RH+RK LG EG+G Sbjct: 311 AVVRHMRKLQLGTSQEGQG 329 >gi|9966875 calcium/calmodulin-dependent protein kinase ID isoform 1 [Homo sapiens] Length = 357 Score = 457 bits (1177), Expect = e-129 Identities = 215/310 (69%), Positives = 269/310 (86%), Gaps = 1/310 (0%) Query: 88 KKHTEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAV 147 KK EDI ++E +E LG+GAFSEVVLA+E+ + L A+KCIPKKAL+GKE+ +ENEIAV Sbjct: 13 KKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAV 72 Query: 148 LRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAV 207 LR+I H NIVALED++ESP+HLYL M+LV+GGELFDRI+E+G YTEKDAS L+ QVL AV Sbjct: 73 LRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAV 132 Query: 208 SYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQA-GNMLGTACGTPGYVAPEL 266 YLH +GIVHRDLKPENLLY + E+SKIM+SDFGLSK++ G+++ TACGTPGYVAPE+ Sbjct: 133 YYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEV 192 Query: 267 LEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESA 326 L QKPY KAVD W++GVI+YILLCGYPPFYDE+D +LF QIL+A YEFDSP+WDDIS+SA Sbjct: 193 LAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSA 252 Query: 327 KDFIRHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGSVSEQIRKNFARTHWKRAFNA 386 KDFIR+L+E+DP KR+TC+QA RH WI+GDTA +++I SVS QIRKNFA++ W++AFNA Sbjct: 253 KDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNFAKSKWRQAFNA 312 Query: 387 TSFLRHIRKL 396 T+ +RH+RKL Sbjct: 313 TAVVRHMRKL 322 >gi|23943850 calcium/calmodulin-dependent protein kinase ID isoform 2 [Homo sapiens] Length = 385 Score = 457 bits (1177), Expect = e-129 Identities = 215/310 (69%), Positives = 269/310 (86%), Gaps = 1/310 (0%) Query: 88 KKHTEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAV 147 KK EDI ++E +E LG+GAFSEVVLA+E+ + L A+KCIPKKAL+GKE+ +ENEIAV Sbjct: 13 KKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAV 72 Query: 148 LRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAV 207 LR+I H NIVALED++ESP+HLYL M+LV+GGELFDRI+E+G YTEKDAS L+ QVL AV Sbjct: 73 LRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAV 132 Query: 208 SYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQA-GNMLGTACGTPGYVAPEL 266 YLH +GIVHRDLKPENLLY + E+SKIM+SDFGLSK++ G+++ TACGTPGYVAPE+ Sbjct: 133 YYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEV 192 Query: 267 LEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESA 326 L QKPY KAVD W++GVI+YILLCGYPPFYDE+D +LF QIL+A YEFDSP+WDDIS+SA Sbjct: 193 LAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSA 252 Query: 327 KDFIRHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGSVSEQIRKNFARTHWKRAFNA 386 KDFIR+L+E+DP KR+TC+QA RH WI+GDTA +++I SVS QIRKNFA++ W++AFNA Sbjct: 253 KDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNFAKSKWRQAFNA 312 Query: 387 TSFLRHIRKL 396 T+ +RH+RKL Sbjct: 313 TAVVRHMRKL 322 >gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo sapiens] Length = 476 Score = 406 bits (1043), Expect = e-113 Identities = 196/309 (63%), Positives = 247/309 (79%), Gaps = 1/309 (0%) Query: 88 KKHTEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAV 147 KK T +I + E LGSGAFSEV L ++R + L ALKCI KK+ +++ +ENEIAV Sbjct: 13 KKQTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCI-KKSPAFRDSSLENEIAV 71 Query: 148 LRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAV 207 L++I H NIV LED++ES +H YL M+LV+GGELFDRI+ERG YTEKDAS ++ QVL AV Sbjct: 72 LKKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAV 131 Query: 208 SYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNMLGTACGTPGYVAPELL 267 YLH GIVHRDLKPENLLY TP E+SKIM++DFGLSK++ ++ TACGTPGYVAPE+L Sbjct: 132 KYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTACGTPGYVAPEVL 191 Query: 268 EQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAK 327 QKPY KAVD W++GVI+YILLCGYPPFY+E++ +LF +I YEF+SPFWDDISESAK Sbjct: 192 AQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAK 251 Query: 328 DFIRHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGSVSEQIRKNFARTHWKRAFNAT 387 DFI HLLE+DP +R+TC++AL H WI G+TA RDI SVS QI+KNFA++ W++AFNA Sbjct: 252 DFICHLLEKDPNERYTCEKALSHPWIDGNTALHRDIYPSVSLQIQKNFAKSKWRQAFNAA 311 Query: 388 SFLRHIRKL 396 + + H+RKL Sbjct: 312 AVVHHMRKL 320 >gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo sapiens] Length = 473 Score = 278 bits (710), Expect = 9e-75 Identities = 149/332 (44%), Positives = 210/332 (63%), Gaps = 14/332 (4%) Query: 94 ISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRISH 153 +S +E+ LG GA S V +++G+ ALK + K + +V EI VL R+SH Sbjct: 42 LSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTV---DKKIVRTEIGVLLRLSH 98 Query: 154 PNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSL 213 PNI+ L+++ E+P+ + L +ELVTGGELFDRI+E+G Y+E+DA+ V Q+L AV+YLH Sbjct: 99 PNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHEN 158 Query: 214 GIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNML-GTACGTPGYVAPELLEQKPY 272 GIVHRDLKPENLLYATP D+ + ++DFGLSKI +L T CGTPGY APE+L Y Sbjct: 159 GIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAY 218 Query: 273 GKAVDVWALGVISYILLCGYPPFYDE-SDPELFSQILRASYEFDSPFWDDISESAKDFIR 331 G VD+W++G+I+YILLCG+ PFYDE D +F +IL Y F SP+WD++S +AKD +R Sbjct: 219 GPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVR 278 Query: 332 HLLERDPQKRFTCQQALRHLWISGDTAFDRDILGSVSEQIRKNFARTHWKRAFNATSFLR 391 L+ DP+KR T QAL+H W++G A + + + +++++ AR K A A Sbjct: 279 KLIVLDPKKRLTTFQALQHPWVTGKAA-NFVHMDTAQKKLQEFNARRKLKAAVKAVVASS 337 Query: 392 HIRKLGQIPEGEGASEQGMARHSHSGLRAGQP 423 + G +S G + SH R P Sbjct: 338 RL--------GSASSSHGSIQESHKASRDPSP 361 >gi|83776596 CaM kinase-like vesicle-associated [Homo sapiens] Length = 501 Score = 271 bits (692), Expect = 1e-72 Identities = 134/310 (43%), Positives = 204/310 (65%), Gaps = 9/310 (2%) Query: 93 DISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRIS 152 +++ Y++ + + + F E+ A+++ + L K K+ R +NEI +L+ + Sbjct: 19 EVTDRYDLGQVIKTEEFCEIFRAKDKTTGKLHTCKKFQKRDGRKVRKAAKNEIGILKMVK 78 Query: 153 HPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHS 212 HPNI+ L DV + ++ +EL TG E+FD I+++G Y+E+D S++V QVL AV+YLHS Sbjct: 79 HPNILQLVDVFVTRKEYFIFLELATGREVFDWILDQGYYSERDTSNVVRQVLEAVAYLHS 138 Query: 213 LGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNMLGTACGTPGYVAPELLEQKPY 272 L IVHR+LK ENL+Y ++SKI++SDF L+K++ G ++ CGTP Y+APE++ ++ Y Sbjct: 139 LKIVHRNLKLENLVYYNRLKNSKIVISDFHLAKLENG-LIKEPCGTPEYLAPEVVGRQRY 197 Query: 273 GKAVDVWALGVISYILLCGYPPFYDE--------SDPELFSQILRASYEFDSPFWDDISE 324 G+ VD WA+GVI YILL G PPFY+E D LF +IL YEFDSP+WDDIS+ Sbjct: 198 GRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDSPYWDDISQ 257 Query: 325 SAKDFIRHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGSVSEQIRKNFARTHWKRAF 384 +AKD + L+E + +R T ++A+ H WISG+ A D++I V QI KNFAR WK+A Sbjct: 258 AAKDLVTRLMEVEQDQRITAEEAISHEWISGNAASDKNIKDGVCAQIEKNFARAKWKKAV 317 Query: 385 NATSFLRHIR 394 T+ ++ +R Sbjct: 318 RVTTLMKRLR 327 >gi|27901803 protein serine kinase H1 [Homo sapiens] Length = 424 Score = 258 bits (658), Expect = 9e-69 Identities = 133/285 (46%), Positives = 186/285 (65%), Gaps = 6/285 (2%) Query: 94 ISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRISH 153 +++ Y+I+ +G G+FS VV + R + A+K I K G+E + E+E+ VLRR+ H Sbjct: 94 VTAKYDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGRE-VCESELRVLRRVRH 152 Query: 154 PNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSL 213 NI+ L +V E+ +Y+ MEL TGGELFDRI+ +GS+TE+DA+ ++ VL V YLH+L Sbjct: 153 ANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLHAL 212 Query: 214 GIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGN---MLGTACGTPGYVAPELLEQK 270 GI HRDLKPENLLY P DSKI+++DFGL+ + ++ T CGTP Y+APE+L +K Sbjct: 213 GITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLVRK 272 Query: 271 PYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFI 330 PY +VD+WALGVI+YILL G PF D++ L+ QILR Y + W +S AKDFI Sbjct: 273 PYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKDFI 332 Query: 331 RHLLERDPQKRFTCQQALRHLWISGDTAFD--RDILGSVSEQIRK 373 LL DP R T QALRH W+ A +++ S+S+ + K Sbjct: 333 DRLLTVDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQNLLK 377 >gi|4758128 doublecortin-like kinase 1 [Homo sapiens] Length = 729 Score = 254 bits (650), Expect = 8e-68 Identities = 133/285 (46%), Positives = 184/285 (64%), Gaps = 4/285 (1%) Query: 94 ISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRISH 153 I+ Y++ +G G F+ V ER +A ALK I K RGKE +++NE+++LRR+ H Sbjct: 386 ITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKH 445 Query: 154 PNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSL 213 PNIV L + + P+ LYL MELV GG+LFD I YTE+DAS ++ + A+ YLHSL Sbjct: 446 PNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSL 505 Query: 214 GIVHRDLKPENLLYATPFEDSK-IMVSDFGLSKIQAGNMLGTACGTPGYVAPELLEQKPY 272 IVHRD+KPENLL + SK + + DFGL+ I G L T CGTP YVAPE++ + Y Sbjct: 506 NIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDG-PLYTVCGTPTYVAPEIIAETGY 564 Query: 273 GKAVDVWALGVISYILLCGYPPFYDESDPE--LFSQILRASYEFDSPFWDDISESAKDFI 330 G VD+WA GVI+YILLCG+PPF D + LF QIL +F SP+WD++S+SAK+ I Sbjct: 565 GLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELI 624 Query: 331 RHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGSVSEQIRKNF 375 +L D +RF+ Q L H W++ D + + SV+ +I+K+F Sbjct: 625 TMMLLVDVDQRFSAVQVLEHPWVNDDGLPENEHQLSVAGKIKKHF 669 >gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens] Length = 766 Score = 245 bits (626), Expect = 5e-65 Identities = 138/346 (39%), Positives = 202/346 (58%), Gaps = 7/346 (2%) Query: 33 PKSSPGDSHRWCKGPGAGPAGPQLREAARASSGLGGGGRHPSRIPAIALQDMLLLKKHTE 92 PKS+ S PG+ Q+ R+SS + GG I + + T Sbjct: 332 PKSTKSSSSS-PTSPGSFRGLKQISAHGRSSSNVNGGPELDRCISPEGVNGNRCSESST- 389 Query: 93 DISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRIS 152 + Y+I + +G G F+ V +R + ALK I K GKE L+ENE+++LRR+ Sbjct: 390 -LLEKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHLIENEVSILRRVK 448 Query: 153 HPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHS 212 HPNI+ L + E+ + L+L MELV GG+LFD I YTE+D S +V + A+ YLH Sbjct: 449 HPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHG 508 Query: 213 LGIVHRDLKPENLLYAT-PFEDSKIMVSDFGLSKIQAGNMLGTACGTPGYVAPELLEQKP 271 L IVHRD+KPENLL P + + DFGL+ + G L T CGTP YVAPE++ + Sbjct: 509 LSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEG-PLYTVCGTPTYVAPEIIAETG 567 Query: 272 YGKAVDVWALGVISYILLCGYPPFYDESD--PELFSQILRASYEFDSPFWDDISESAKDF 329 YG VD+WA GVI+YILLCG+PPF E++ +LF QIL EF +P+WD+I++SAK+ Sbjct: 568 YGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKEL 627 Query: 330 IRHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGSVSEQIRKNF 375 I +L+ + + R T Q L H W+S D + + ++ V+ +++++F Sbjct: 628 ISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHF 673 >gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens] Length = 765 Score = 243 bits (619), Expect = 3e-64 Identities = 132/326 (40%), Positives = 195/326 (59%), Gaps = 6/326 (1%) Query: 53 GPQLREAARASSGLGGGGRHPSRIPAIALQDMLLLKKHTEDISSVYEIRERLGSGAFSEV 112 G ++ R+SS + GG I + + T + Y+I + +G G F+ V Sbjct: 350 GLKISAHGRSSSNVNGGPELDRCISPEGVNGNRCSESST--LLEKYKIGKVIGDGNFAVV 407 Query: 113 VLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRISHPNIVALEDVHESPSHLYLA 172 +R + ALK I K GKE L+ENE+++LRR+ HPNI+ L + E+ + L+L Sbjct: 408 KECIDRSTGKEFALKIIDKAKCCGKEHLIENEVSILRRVKHPNIIMLVEEMETATELFLV 467 Query: 173 MELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYAT-PF 231 MELV GG+LFD I YTE+D S +V + A+ YLH L IVHRD+KPENLL P Sbjct: 468 MELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPD 527 Query: 232 EDSKIMVSDFGLSKIQAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLCG 291 + + DFGL+ + G L T CGTP YVAPE++ + YG VD+WA GVI+YILLCG Sbjct: 528 GTKSLKLGDFGLATVVEG-PLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCG 586 Query: 292 YPPFYDESD--PELFSQILRASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALR 349 +PPF E++ +LF QIL EF +P+WD+I++SAK+ I +L+ + + R T Q L Sbjct: 587 FPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGQILS 646 Query: 350 HLWISGDTAFDRDILGSVSEQIRKNF 375 H W+S D + + ++ V+ +++++F Sbjct: 647 HPWVSDDASQENNMQAEVTGKLKQHF 672 >gi|14916455 protein serine kinase H2 [Homo sapiens] Length = 385 Score = 243 bits (619), Expect = 3e-64 Identities = 140/351 (39%), Positives = 205/351 (58%), Gaps = 15/351 (4%) Query: 38 GDSHRWCKGPGAGPAGPQLREAARASSGLGGGGRHPSRIPAIA--LQDMLLLKKHTEDIS 95 G S + GP PA + + +G+GG G P A +Q K + Sbjct: 4 GASRKVVPGP---PALAWAKHEGQNQAGVGGAGPGPEAAAQAAQRIQVARFRAKFDPRVL 60 Query: 96 SVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRISHPN 155 + Y+I+ +G+G+FS VV +++ + A+K + + G+EA V +E++VLRR+SH Sbjct: 61 ARYDIKALIGTGSFSRVVRVEQKTTKKPFAIKVMETREREGREACV-SELSVLRRVSHRY 119 Query: 156 IVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGI 215 IV L ++ E+ +Y+ MEL TGGELFDR++ +GS+TE+DA ++ V + YLH+L I Sbjct: 120 IVQLMEIFETEDQVYMVMELATGGELFDRLIAQGSFTERDAVRILQMVADGIRYLHALQI 179 Query: 216 VHRDLKPENLLYATPFEDSKIMVSDFGLS---KIQAGNMLGTACGTPGYVAPELLEQKPY 272 HR+LKPENLLY P E+SKI+++DFGL+ K + T CGTP Y+APE+L +KPY Sbjct: 180 THRNLKPENLLYYHPGEESKILITDFGLAYSGKKSGDWTMKTLCGTPEYIAPEVLLRKPY 239 Query: 273 GKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRH 332 AVD+WALGVI+Y LL G+ PF DES L+ +IL+ Y + W IS AKDFI Sbjct: 240 TSAVDMWALGVITYALLSGFLPFDDESQTRLYRKILKGKYNYTGEPWPSISHLAKDFIDK 299 Query: 333 LLERDPQKRFTCQQALRHLWISGDTAFDRDILGSVSEQIRKNFARTHWKRA 383 LL + R + QAL H W+ A GS + +++ +R +RA Sbjct: 300 LLILEAGHRMSAGQALDHPWVITMAA------GSSMKNLQRAISRNLMQRA 344 >gi|25952118 calcium/calmodulin-dependent protein kinase II alpha isoform 2 [Homo sapiens] Length = 478 Score = 230 bits (586), Expect = 2e-60 Identities = 122/261 (46%), Positives = 162/261 (62%), Gaps = 5/261 (1%) Query: 98 YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKE-ALVENEIAVLRRISHPNI 156 Y++ E LG GAFS V + + A K I K L ++ +E E + R + HPNI Sbjct: 13 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 72 Query: 157 VALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIV 216 V L D H YL +LVTGGELF+ I+ R Y+E DASH + Q+L AV + H +G+V Sbjct: 73 VRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV 132 Query: 217 HRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNM---LGTACGTPGYVAPELLEQKPYG 273 HRDLKPENLL A+ + + + ++DFGL+ G G A GTPGY++PE+L + PYG Sbjct: 133 HRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFA-GTPGYLSPEVLRKDPYG 191 Query: 274 KAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHL 333 K VD+WA GVI YILL GYPPF+DE L+ QI +Y+F SP WD ++ AKD I + Sbjct: 192 KPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKM 251 Query: 334 LERDPQKRFTCQQALRHLWIS 354 L +P KR T +AL+H WIS Sbjct: 252 LTINPSKRITAAEALKHPWIS 272 >gi|25952114 calcium/calmodulin-dependent protein kinase II alpha isoform 1 [Homo sapiens] Length = 489 Score = 230 bits (586), Expect = 2e-60 Identities = 122/261 (46%), Positives = 162/261 (62%), Gaps = 5/261 (1%) Query: 98 YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKE-ALVENEIAVLRRISHPNI 156 Y++ E LG GAFS V + + A K I K L ++ +E E + R + HPNI Sbjct: 13 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 72 Query: 157 VALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIV 216 V L D H YL +LVTGGELF+ I+ R Y+E DASH + Q+L AV + H +G+V Sbjct: 73 VRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV 132 Query: 217 HRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNM---LGTACGTPGYVAPELLEQKPYG 273 HRDLKPENLL A+ + + + ++DFGL+ G G A GTPGY++PE+L + PYG Sbjct: 133 HRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFA-GTPGYLSPEVLRKDPYG 191 Query: 274 KAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHL 333 K VD+WA GVI YILL GYPPF+DE L+ QI +Y+F SP WD ++ AKD I + Sbjct: 192 KPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKM 251 Query: 334 LERDPQKRFTCQQALRHLWIS 354 L +P KR T +AL+H WIS Sbjct: 252 LTINPSKRITAAEALKHPWIS 272 >gi|26667196 calcium/calmodulin-dependent protein kinase II gamma isoform 2 [Homo sapiens] Length = 527 Score = 229 bits (583), Expect = 5e-60 Identities = 135/329 (41%), Positives = 184/329 (55%), Gaps = 9/329 (2%) Query: 98 YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKE-ALVENEIAVLRRISHPNI 156 Y++ E LG GAFS V ++ S A K I K L ++ +E E + R + HPNI Sbjct: 14 YQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 73 Query: 157 VALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIV 216 V L D YL +LVTGGELF+ I+ R Y+E DASH + Q+L +V+++H IV Sbjct: 74 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIV 133 Query: 217 HRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNM---LGTACGTPGYVAPELLEQKPYG 273 HRDLKPENLL A+ + + + ++DFGL+ G G A GTPGY++PE+L + PYG Sbjct: 134 HRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFA-GTPGYLSPEVLRKDPYG 192 Query: 274 KAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHL 333 K VD+WA GVI YILL GYPPF+DE +L+ QI +Y+F SP WD ++ AK+ I + Sbjct: 193 KPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQM 252 Query: 334 LERDPQKRFTCQQALRHLWI-SGDTAFDRDILGSVSEQIRKNFARTHWKRAFNATSFLRH 392 L +P KR T QAL+H W+ T E +RK AR K A T + Sbjct: 253 LTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSR 312 Query: 393 IRKLGQ---IPEGEGASEQGMARHSHSGL 418 +G+ P AS G+A + L Sbjct: 313 NFSVGRQSSAPASPAASAAGLAGQAAKSL 341 >gi|149589021 doublecortin-like kinase 3 [Homo sapiens] Length = 648 Score = 226 bits (576), Expect = 3e-59 Identities = 117/264 (44%), Positives = 168/264 (63%), Gaps = 4/264 (1%) Query: 93 DISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRIS 152 ++ YE +G G F+ V + R + A+K I K L+GKE +V++EI +++ +S Sbjct: 351 NVEKHYETGRVIGDGNFAVVKECRHRETRQAYAMKIIDKSRLKGKEDMVDSEILIIQSLS 410 Query: 153 HPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHS 212 HPNIV L +V+E+ +YL +E V GG+LFD I+E + E DA+ ++ + A+ ++H Sbjct: 411 HPNIVKLHEVYETDMEIYLILEYVQGGDLFDAIIESVKFPEPDAALMIMDLCKALVHMHD 470 Query: 213 LGIVHRDLKPENLLYATPFEDS-KIMVSDFGLSKIQAGNMLGTACGTPGYVAPELLEQKP 271 IVHRDLKPENLL + S + ++DFGL+K + T CGTP YVAPE+L +K Sbjct: 471 KSIVHRDLKPENLLVQRNEDKSTTLKLADFGLAK-HVVRPIFTVCGTPTYVAPEILSEKG 529 Query: 272 YGKAVDVWALGVISYILLCGYPPFY--DESDPELFSQILRASYEFDSPFWDDISESAKDF 329 YG VD+WA GVI YILLCG+PPF + ELF+ I +EF P+WD+IS++AKD Sbjct: 530 YGLEVDMWAAGVILYILLCGFPPFRSPERDQDELFNIIQLGHFEFLPPYWDNISDAAKDL 589 Query: 330 IRHLLERDPQKRFTCQQALRHLWI 353 + LL DP+KR+T Q L+H WI Sbjct: 590 VSRLLVVDPKKRYTAHQVLQHPWI 613 >gi|26667199 calcium/calmodulin-dependent protein kinase II gamma isoform 3 [Homo sapiens] Length = 518 Score = 226 bits (575), Expect = 4e-59 Identities = 119/260 (45%), Positives = 162/260 (62%), Gaps = 5/260 (1%) Query: 98 YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKE-ALVENEIAVLRRISHPNI 156 Y++ E LG GAFS V ++ S A K I K L ++ +E E + R + HPNI Sbjct: 14 YQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 73 Query: 157 VALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIV 216 V L D YL +LVTGGELF+ I+ R Y+E DASH + Q+L +V+++H IV Sbjct: 74 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIV 133 Query: 217 HRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNM---LGTACGTPGYVAPELLEQKPYG 273 HRDLKPENLL A+ + + + ++DFGL+ G G A GTPGY++PE+L + PYG Sbjct: 134 HRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFA-GTPGYLSPEVLRKDPYG 192 Query: 274 KAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHL 333 K VD+WA GVI YILL GYPPF+DE +L+ QI +Y+F SP WD ++ AK+ I + Sbjct: 193 KPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQM 252 Query: 334 LERDPQKRFTCQQALRHLWI 353 L +P KR T QAL+H W+ Sbjct: 253 LTINPAKRITADQALKHPWV 272 >gi|26667191 calcium/calmodulin-dependent protein kinase II gamma isoform 4 [Homo sapiens] Length = 495 Score = 226 bits (575), Expect = 4e-59 Identities = 119/260 (45%), Positives = 162/260 (62%), Gaps = 5/260 (1%) Query: 98 YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKE-ALVENEIAVLRRISHPNI 156 Y++ E LG GAFS V ++ S A K I K L ++ +E E + R + HPNI Sbjct: 14 YQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 73 Query: 157 VALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIV 216 V L D YL +LVTGGELF+ I+ R Y+E DASH + Q+L +V+++H IV Sbjct: 74 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIV 133 Query: 217 HRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNM---LGTACGTPGYVAPELLEQKPYG 273 HRDLKPENLL A+ + + + ++DFGL+ G G A GTPGY++PE+L + PYG Sbjct: 134 HRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFA-GTPGYLSPEVLRKDPYG 192 Query: 274 KAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHL 333 K VD+WA GVI YILL GYPPF+DE +L+ QI +Y+F SP WD ++ AK+ I + Sbjct: 193 KPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQM 252 Query: 334 LERDPQKRFTCQQALRHLWI 353 L +P KR T QAL+H W+ Sbjct: 253 LTINPAKRITADQALKHPWV 272 >gi|26667211 calcium/calmodulin-dependent protein kinase II gamma isoform 6 [Homo sapiens] Length = 504 Score = 226 bits (575), Expect = 4e-59 Identities = 119/260 (45%), Positives = 162/260 (62%), Gaps = 5/260 (1%) Query: 98 YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKE-ALVENEIAVLRRISHPNI 156 Y++ E LG GAFS V ++ S A K I K L ++ +E E + R + HPNI Sbjct: 14 YQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 73 Query: 157 VALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIV 216 V L D YL +LVTGGELF+ I+ R Y+E DASH + Q+L +V+++H IV Sbjct: 74 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIV 133 Query: 217 HRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNM---LGTACGTPGYVAPELLEQKPYG 273 HRDLKPENLL A+ + + + ++DFGL+ G G A GTPGY++PE+L + PYG Sbjct: 134 HRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFA-GTPGYLSPEVLRKDPYG 192 Query: 274 KAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHL 333 K VD+WA GVI YILL GYPPF+DE +L+ QI +Y+F SP WD ++ AK+ I + Sbjct: 193 KPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQM 252 Query: 334 LERDPQKRFTCQQALRHLWI 353 L +P KR T QAL+H W+ Sbjct: 253 LTINPAKRITADQALKHPWV 272 >gi|26667203 calcium/calmodulin-dependent protein kinase II gamma isoform 1 [Homo sapiens] Length = 556 Score = 226 bits (575), Expect = 4e-59 Identities = 119/260 (45%), Positives = 162/260 (62%), Gaps = 5/260 (1%) Query: 98 YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKE-ALVENEIAVLRRISHPNI 156 Y++ E LG GAFS V ++ S A K I K L ++ +E E + R + HPNI Sbjct: 14 YQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 73 Query: 157 VALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIV 216 V L D YL +LVTGGELF+ I+ R Y+E DASH + Q+L +V+++H IV Sbjct: 74 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIV 133 Query: 217 HRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNM---LGTACGTPGYVAPELLEQKPYG 273 HRDLKPENLL A+ + + + ++DFGL+ G G A GTPGY++PE+L + PYG Sbjct: 134 HRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFA-GTPGYLSPEVLRKDPYG 192 Query: 274 KAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHL 333 K VD+WA GVI YILL GYPPF+DE +L+ QI +Y+F SP WD ++ AK+ I + Sbjct: 193 KPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQM 252 Query: 334 LERDPQKRFTCQQALRHLWI 353 L +P KR T QAL+H W+ Sbjct: 253 LTINPAKRITADQALKHPWV 272 >gi|212549756 calcium/calmodulin-dependent protein kinase II delta isoform 4 [Homo sapiens] Length = 489 Score = 224 bits (571), Expect = 1e-58 Identities = 120/260 (46%), Positives = 161/260 (61%), Gaps = 5/260 (1%) Query: 98 YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKE-ALVENEIAVLRRISHPNI 156 Y++ E LG GAFS V + + A K I K L ++ +E E + R + HPNI Sbjct: 14 YQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 73 Query: 157 VALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIV 216 V L D YL +LVTGGELF+ I+ R Y+E DASH + Q+L +V++ H GIV Sbjct: 74 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIV 133 Query: 217 HRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNM---LGTACGTPGYVAPELLEQKPYG 273 HRDLKPENLL A+ + + + ++DFGL+ G+ G A GTPGY++PE+L + PYG Sbjct: 134 HRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFA-GTPGYLSPEVLRKDPYG 192 Query: 274 KAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHL 333 K VD+WA GVI YILL GYPPF+DE L+ QI +Y+F SP WD ++ AKD I + Sbjct: 193 KPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKM 252 Query: 334 LERDPQKRFTCQQALRHLWI 353 L +P KR T +AL+H WI Sbjct: 253 LTINPAKRITASEALKHPWI 272 >gi|26667183 calcium/calmodulin-dependent protein kinase II delta isoform 1 [Homo sapiens] Length = 478 Score = 224 bits (571), Expect = 1e-58 Identities = 120/260 (46%), Positives = 161/260 (61%), Gaps = 5/260 (1%) Query: 98 YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKE-ALVENEIAVLRRISHPNI 156 Y++ E LG GAFS V + + A K I K L ++ +E E + R + HPNI Sbjct: 14 YQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 73 Query: 157 VALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIV 216 V L D YL +LVTGGELF+ I+ R Y+E DASH + Q+L +V++ H GIV Sbjct: 74 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIV 133 Query: 217 HRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNM---LGTACGTPGYVAPELLEQKPYG 273 HRDLKPENLL A+ + + + ++DFGL+ G+ G A GTPGY++PE+L + PYG Sbjct: 134 HRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFA-GTPGYLSPEVLRKDPYG 192 Query: 274 KAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHL 333 K VD+WA GVI YILL GYPPF+DE L+ QI +Y+F SP WD ++ AKD I + Sbjct: 193 KPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKM 252 Query: 334 LERDPQKRFTCQQALRHLWI 353 L +P KR T +AL+H WI Sbjct: 253 LTINPAKRITASEALKHPWI 272 >gi|212549753 calcium/calmodulin-dependent protein kinase II delta isoform 5 [Homo sapiens] Length = 492 Score = 224 bits (571), Expect = 1e-58 Identities = 120/260 (46%), Positives = 161/260 (61%), Gaps = 5/260 (1%) Query: 98 YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKE-ALVENEIAVLRRISHPNI 156 Y++ E LG GAFS V + + A K I K L ++ +E E + R + HPNI Sbjct: 14 YQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 73 Query: 157 VALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIV 216 V L D YL +LVTGGELF+ I+ R Y+E DASH + Q+L +V++ H GIV Sbjct: 74 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIV 133 Query: 217 HRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNM---LGTACGTPGYVAPELLEQKPYG 273 HRDLKPENLL A+ + + + ++DFGL+ G+ G A GTPGY++PE+L + PYG Sbjct: 134 HRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFA-GTPGYLSPEVLRKDPYG 192 Query: 274 KAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHL 333 K VD+WA GVI YILL GYPPF+DE L+ QI +Y+F SP WD ++ AKD I + Sbjct: 193 KPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKM 252 Query: 334 LERDPQKRFTCQQALRHLWI 353 L +P KR T +AL+H WI Sbjct: 253 LTINPAKRITASEALKHPWI 272 >gi|26667186 calcium/calmodulin-dependent protein kinase II delta isoform 1 [Homo sapiens] Length = 478 Score = 224 bits (571), Expect = 1e-58 Identities = 120/260 (46%), Positives = 161/260 (61%), Gaps = 5/260 (1%) Query: 98 YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKE-ALVENEIAVLRRISHPNI 156 Y++ E LG GAFS V + + A K I K L ++ +E E + R + HPNI Sbjct: 14 YQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 73 Query: 157 VALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIV 216 V L D YL +LVTGGELF+ I+ R Y+E DASH + Q+L +V++ H GIV Sbjct: 74 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIV 133 Query: 217 HRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNM---LGTACGTPGYVAPELLEQKPYG 273 HRDLKPENLL A+ + + + ++DFGL+ G+ G A GTPGY++PE+L + PYG Sbjct: 134 HRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFA-GTPGYLSPEVLRKDPYG 192 Query: 274 KAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHL 333 K VD+WA GVI YILL GYPPF+DE L+ QI +Y+F SP WD ++ AKD I + Sbjct: 193 KPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKM 252 Query: 334 LERDPQKRFTCQQALRHLWI 353 L +P KR T +AL+H WI Sbjct: 253 LTINPAKRITASEALKHPWI 272 >gi|26667189 calcium/calmodulin-dependent protein kinase II delta isoform 2 [Homo sapiens] Length = 478 Score = 224 bits (571), Expect = 1e-58 Identities = 120/260 (46%), Positives = 161/260 (61%), Gaps = 5/260 (1%) Query: 98 YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKE-ALVENEIAVLRRISHPNI 156 Y++ E LG GAFS V + + A K I K L ++ +E E + R + HPNI Sbjct: 14 YQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 73 Query: 157 VALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIV 216 V L D YL +LVTGGELF+ I+ R Y+E DASH + Q+L +V++ H GIV Sbjct: 74 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIV 133 Query: 217 HRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNM---LGTACGTPGYVAPELLEQKPYG 273 HRDLKPENLL A+ + + + ++DFGL+ G+ G A GTPGY++PE+L + PYG Sbjct: 134 HRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFA-GTPGYLSPEVLRKDPYG 192 Query: 274 KAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHL 333 K VD+WA GVI YILL GYPPF+DE L+ QI +Y+F SP WD ++ AKD I + Sbjct: 193 KPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKM 252 Query: 334 LERDPQKRFTCQQALRHLWI 353 L +P KR T +AL+H WI Sbjct: 253 LTINPAKRITASEALKHPWI 272 >gi|26667180 calcium/calmodulin-dependent protein kinase II delta isoform 3 [Homo sapiens] Length = 499 Score = 224 bits (571), Expect = 1e-58 Identities = 120/260 (46%), Positives = 161/260 (61%), Gaps = 5/260 (1%) Query: 98 YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKE-ALVENEIAVLRRISHPNI 156 Y++ E LG GAFS V + + A K I K L ++ +E E + R + HPNI Sbjct: 14 YQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 73 Query: 157 VALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIV 216 V L D YL +LVTGGELF+ I+ R Y+E DASH + Q+L +V++ H GIV Sbjct: 74 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIV 133 Query: 217 HRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNM---LGTACGTPGYVAPELLEQKPYG 273 HRDLKPENLL A+ + + + ++DFGL+ G+ G A GTPGY++PE+L + PYG Sbjct: 134 HRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFA-GTPGYLSPEVLRKDPYG 192 Query: 274 KAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHL 333 K VD+WA GVI YILL GYPPF+DE L+ QI +Y+F SP WD ++ AKD I + Sbjct: 193 KPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKM 252 Query: 334 LERDPQKRFTCQQALRHLWI 353 L +P KR T +AL+H WI Sbjct: 253 LTINPAKRITASEALKHPWI 272 >gi|26051204 calcium/calmodulin-dependent protein kinase II beta isoform 1 [Homo sapiens] Length = 666 Score = 221 bits (564), Expect = 7e-58 Identities = 116/260 (44%), Positives = 162/260 (62%), Gaps = 5/260 (1%) Query: 98 YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKE-ALVENEIAVLRRISHPNI 156 Y++ E +G GAFS V + + H A K I K L ++ +E E + R + H NI Sbjct: 14 YQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNI 73 Query: 157 VALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIV 216 V L D YL +LVTGGELF+ I+ R Y+E DASH + Q+L AV + H +G+V Sbjct: 74 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV 133 Query: 217 HRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNM---LGTACGTPGYVAPELLEQKPYG 273 HRDLKPENLL A+ + + + ++DFGL+ G+ G A GTPGY++PE+L ++ YG Sbjct: 134 HRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFA-GTPGYLSPEVLRKEAYG 192 Query: 274 KAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHL 333 K VD+WA GVI YILL GYPPF+DE +L+ QI +Y+F SP WD ++ AK+ I + Sbjct: 193 KPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQM 252 Query: 334 LERDPQKRFTCQQALRHLWI 353 L +P KR T +AL+H W+ Sbjct: 253 LTINPAKRITAHEALKHPWV 272 >gi|26051210 calcium/calmodulin-dependent protein kinase II beta isoform 4 [Homo sapiens] Length = 517 Score = 221 bits (564), Expect = 7e-58 Identities = 116/260 (44%), Positives = 162/260 (62%), Gaps = 5/260 (1%) Query: 98 YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKE-ALVENEIAVLRRISHPNI 156 Y++ E +G GAFS V + + H A K I K L ++ +E E + R + H NI Sbjct: 14 YQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNI 73 Query: 157 VALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIV 216 V L D YL +LVTGGELF+ I+ R Y+E DASH + Q+L AV + H +G+V Sbjct: 74 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV 133 Query: 217 HRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNM---LGTACGTPGYVAPELLEQKPYG 273 HRDLKPENLL A+ + + + ++DFGL+ G+ G A GTPGY++PE+L ++ YG Sbjct: 134 HRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFA-GTPGYLSPEVLRKEAYG 192 Query: 274 KAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHL 333 K VD+WA GVI YILL GYPPF+DE +L+ QI +Y+F SP WD ++ AK+ I + Sbjct: 193 KPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQM 252 Query: 334 LERDPQKRFTCQQALRHLWI 353 L +P KR T +AL+H W+ Sbjct: 253 LTINPAKRITAHEALKHPWV 272 >gi|26051214 calcium/calmodulin-dependent protein kinase II beta isoform 6 [Homo sapiens] Length = 492 Score = 221 bits (564), Expect = 7e-58 Identities = 116/260 (44%), Positives = 162/260 (62%), Gaps = 5/260 (1%) Query: 98 YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKE-ALVENEIAVLRRISHPNI 156 Y++ E +G GAFS V + + H A K I K L ++ +E E + R + H NI Sbjct: 14 YQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNI 73 Query: 157 VALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIV 216 V L D YL +LVTGGELF+ I+ R Y+E DASH + Q+L AV + H +G+V Sbjct: 74 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV 133 Query: 217 HRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNM---LGTACGTPGYVAPELLEQKPYG 273 HRDLKPENLL A+ + + + ++DFGL+ G+ G A GTPGY++PE+L ++ YG Sbjct: 134 HRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFA-GTPGYLSPEVLRKEAYG 192 Query: 274 KAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHL 333 K VD+WA GVI YILL GYPPF+DE +L+ QI +Y+F SP WD ++ AK+ I + Sbjct: 193 KPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQM 252 Query: 334 LERDPQKRFTCQQALRHLWI 353 L +P KR T +AL+H W+ Sbjct: 253 LTINPAKRITAHEALKHPWV 272 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.318 0.136 0.415 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 18,181,916 Number of Sequences: 37866 Number of extensions: 888304 Number of successful extensions: 5549 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 585 Number of HSP's successfully gapped in prelim test: 241 Number of HSP's that attempted gapping in prelim test: 3131 Number of HSP's gapped (non-prelim): 1019 length of query: 426 length of database: 18,247,518 effective HSP length: 105 effective length of query: 321 effective length of database: 14,271,588 effective search space: 4581179748 effective search space used: 4581179748 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.