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Search of human proteins with 208879423
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|208879423 leukocyte receptor tyrosine kinase isoform 3
precursor [Homo sapiens]
(734 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|208879423 leukocyte receptor tyrosine kinase isoform 3 precur... 1524 0.0
gi|46249416 leukocyte receptor tyrosine kinase isoform 2 precurs... 797 0.0
gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precurs... 733 0.0
gi|29029632 anaplastic lymphoma kinase [Homo sapiens] 444 e-124
gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens] 256 5e-68
gi|31657140 insulin receptor-related receptor precursor [Homo sa... 234 2e-61
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo... 230 3e-60
gi|119395738 insulin receptor isoform Short precursor [Homo sapi... 224 2e-58
gi|119395736 insulin receptor isoform Long precursor [Homo sapiens] 224 2e-58
gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isofo... 209 6e-54
gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isofor... 209 6e-54
gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isofo... 209 6e-54
gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens] 197 3e-50
gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens] 197 3e-50
gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens] 197 3e-50
gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens] 197 3e-50
gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isofo... 195 1e-49
gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isofo... 195 1e-49
gi|21536468 AXL receptor tyrosine kinase isoform 2 [Homo sapiens] 191 2e-48
gi|21536466 AXL receptor tyrosine kinase isoform 1 [Homo sapiens] 191 2e-48
gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [... 189 6e-48
gi|22902130 PTK7 protein tyrosine kinase 7 isoform d precursor [... 189 6e-48
gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor [... 189 6e-48
gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor [... 189 6e-48
gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens] 188 1e-47
gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isofo... 188 2e-47
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens] 187 3e-47
gi|134152725 receptor tyrosine kinase-like orphan receptor 1 iso... 183 6e-46
gi|130977759 tec protein tyrosine kinase [Homo sapiens] 181 3e-45
gi|27597078 TYRO3 protein tyrosine kinase [Homo sapiens] 181 3e-45
>gi|208879423 leukocyte receptor tyrosine kinase isoform 3 precursor
[Homo sapiens]
Length = 734
Score = 1524 bits (3945), Expect = 0.0
Identities = 734/734 (100%), Positives = 734/734 (100%)
Query: 1 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN 60
MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN
Sbjct: 1 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN 60
Query: 61 SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL 120
SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL
Sbjct: 61 SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL 120
Query: 121 ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL 180
ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL
Sbjct: 121 ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL 180
Query: 181 GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL 240
GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL
Sbjct: 181 GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL 240
Query: 241 RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGDASETDNLWADGEDGVSFIHPSSELFL 300
RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGDASETDNLWADGEDGVSFIHPSSELFL
Sbjct: 241 RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGDASETDNLWADGEDGVSFIHPSSELFL 300
Query: 301 QPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHKP 360
QPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHKP
Sbjct: 301 QPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHKP 360
Query: 361 PGPLVLMVAVVATSTLSLLMVCGVLILGGAWPGPVLASATRCHRGFPSQCYSAQTLPELC 420
PGPLVLMVAVVATSTLSLLMVCGVLILGGAWPGPVLASATRCHRGFPSQCYSAQTLPELC
Sbjct: 361 PGPLVLMVAVVATSTLSLLMVCGVLILGGAWPGPVLASATRCHRGFPSQCYSAQTLPELC 420
Query: 421 SPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLG 480
SPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLG
Sbjct: 421 SPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLG 480
Query: 481 QPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARD 540
QPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARD
Sbjct: 481 QPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARD 540
Query: 541 IYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQ 600
IYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQ
Sbjct: 541 IYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQ 600
Query: 601 EVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDPDVLNSL 660
EVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDPDVLNSL
Sbjct: 601 EVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDPDVLNSL 660
Query: 661 LPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWLSSGLKPLKSR 720
LPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWLSSGLKPLKSR
Sbjct: 661 LPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWLSSGLKPLKSR 720
Query: 721 GLQPQNLWNPTYRS 734
GLQPQNLWNPTYRS
Sbjct: 721 GLQPQNLWNPTYRS 734
>gi|46249416 leukocyte receptor tyrosine kinase isoform 2 precursor
[Homo sapiens]
Length = 803
Score = 797 bits (2058), Expect = 0.0
Identities = 387/387 (100%), Positives = 387/387 (100%)
Query: 1 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN 60
MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN
Sbjct: 1 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN 60
Query: 61 SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL 120
SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL
Sbjct: 61 SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL 120
Query: 121 ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL 180
ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL
Sbjct: 121 ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL 180
Query: 181 GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL 240
GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL
Sbjct: 181 GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL 240
Query: 241 RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGDASETDNLWADGEDGVSFIHPSSELFL 300
RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGDASETDNLWADGEDGVSFIHPSSELFL
Sbjct: 241 RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGDASETDNLWADGEDGVSFIHPSSELFL 300
Query: 301 QPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHKP 360
QPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHKP
Sbjct: 301 QPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHKP 360
Query: 361 PGPLVLMVAVVATSTLSLLMVCGVLIL 387
PGPLVLMVAVVATSTLSLLMVCGVLIL
Sbjct: 361 PGPLVLMVAVVATSTLSLLMVCGVLIL 387
Score = 675 bits (1741), Expect = 0.0
Identities = 334/379 (88%), Positives = 340/379 (89%), Gaps = 17/379 (4%)
Query: 360 PPGPLVLMVAVVATSTLSLLMVCGVLILGGAWPGPVLASATRCHRGFPSQCYSAQ----T 415
PPG V V+ + ++LL G G + G V+ G P Q T
Sbjct: 438 PPG-----VTEVSPANVTLLRALGHGAFGEVYEGLVI--------GLPGDSSPLQVAIKT 484
Query: 416 LPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHS 475
LPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHS
Sbjct: 485 LPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHS 544
Query: 476 RPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDF 535
RPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDF
Sbjct: 545 RPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDF 604
Query: 536 GMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYP 595
GMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYP
Sbjct: 605 GMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYP 664
Query: 596 GRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDPD 655
GRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDPD
Sbjct: 665 GRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDPD 724
Query: 656 VLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWLSSGLK 715
VLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWLSSGLK
Sbjct: 725 VLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWLSSGLK 784
Query: 716 PLKSRGLQPQNLWNPTYRS 734
PLKSRGLQPQNLWNPTYRS
Sbjct: 785 PLKSRGLQPQNLWNPTYRS 803
>gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precursor
[Homo sapiens]
Length = 864
Score = 733 bits (1891), Expect = 0.0
Identities = 372/448 (83%), Positives = 374/448 (83%), Gaps = 61/448 (13%)
Query: 1 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN 60
MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN
Sbjct: 1 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN 60
Query: 61 SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL 120
SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL
Sbjct: 61 SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL 120
Query: 121 ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL 180
ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL
Sbjct: 121 ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL 180
Query: 181 GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL 240
GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL
Sbjct: 181 GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL 240
Query: 241 RPRDRGR------------------------------TQASPEKLENRSEAPGS------ 264
RPRDRGR T +P RS G+
Sbjct: 241 RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGC 300
Query: 265 -------------------------GGRGGAAGGDASETDNLWADGEDGVSFIHPSSELF 299
GG GG GGDASETDNLWADGEDGVSFIHPSSELF
Sbjct: 301 SEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELF 360
Query: 300 LQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHK 359
LQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHK
Sbjct: 361 LQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHK 420
Query: 360 PPGPLVLMVAVVATSTLSLLMVCGVLIL 387
PPGPLVLMVAVVATSTLSLLMVCGVLIL
Sbjct: 421 PPGPLVLMVAVVATSTLSLLMVCGVLIL 448
Score = 675 bits (1741), Expect = 0.0
Identities = 334/379 (88%), Positives = 340/379 (89%), Gaps = 17/379 (4%)
Query: 360 PPGPLVLMVAVVATSTLSLLMVCGVLILGGAWPGPVLASATRCHRGFPSQCYSAQ----T 415
PPG V V+ + ++LL G G + G V+ G P Q T
Sbjct: 499 PPG-----VTEVSPANVTLLRALGHGAFGEVYEGLVI--------GLPGDSSPLQVAIKT 545
Query: 416 LPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHS 475
LPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHS
Sbjct: 546 LPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHS 605
Query: 476 RPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDF 535
RPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDF
Sbjct: 606 RPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDF 665
Query: 536 GMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYP 595
GMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYP
Sbjct: 666 GMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYP 725
Query: 596 GRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDPD 655
GRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDPD
Sbjct: 726 GRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDPD 785
Query: 656 VLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWLSSGLK 715
VLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWLSSGLK
Sbjct: 786 VLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWLSSGLK 845
Query: 716 PLKSRGLQPQNLWNPTYRS 734
PLKSRGLQPQNLWNPTYRS
Sbjct: 846 PLKSRGLQPQNLWNPTYRS 864
>gi|29029632 anaplastic lymphoma kinase [Homo sapiens]
Length = 1620
Score = 444 bits (1141), Expect = e-124
Identities = 214/303 (70%), Positives = 248/303 (81%), Gaps = 1/303 (0%)
Query: 412 SAQTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSF 471
+ +TLPE+CS QDELDFLMEALIISKF HQNIVRC+G+SL++ PR ILLELM+GGD+KSF
Sbjct: 1148 AVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSF 1207
Query: 472 LRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAK 531
LR +RP QPS L M DLL +A+DIA GC YLEENHFIHRDIAARNCLL+C GP RVAK
Sbjct: 1208 LRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAK 1267
Query: 532 IGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGY 591
IGDFGMARDIYRASYYR+G A+LPVKWMPPEAF+EGIFTSKTD+WSFGVLLWEIFSLGY
Sbjct: 1268 IGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGY 1327
Query: 592 MPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCT 651
MPYP ++NQEVL+FV GGRMDPP+ CPGPVYRIMTQCWQH+PE RP+FA ILER++YCT
Sbjct: 1328 MPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCT 1387
Query: 652 QDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRP-PQPQELSPEKLKSWGGSPLGPWL 710
QDPDV+N+ LP+E GP EEE + + E + P Q+ E+ +S P P
Sbjct: 1388 QDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTT 1447
Query: 711 SSG 713
SSG
Sbjct: 1448 SSG 1450
Score = 267 bits (682), Expect = 3e-71
Identities = 171/460 (37%), Positives = 233/460 (50%), Gaps = 85/460 (18%)
Query: 4 WGQLLVWFGAAGAILCSSPG---SQETFLRSSP----LPLASPSPRDPKVSAPPSILEPA 56
W Q++ W+G + + S + +L S L +P R+ P L+P
Sbjct: 608 WLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPG 667
Query: 57 --SPLNSPGTEGS--WLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWR 112
SP +P + + WLF+TCGASG HGPTQ QC+ AY +++ V VG+ G L+G+Q+W+
Sbjct: 668 ENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWK 727
Query: 113 VPGPGQYLISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGS 172
VP Y IS YGAAGGKG KN + R+HGV V IF+L + LYILVGQQGEDACP +
Sbjct: 728 VPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTN 787
Query: 173 PESQLVCLGESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAA 232
Q VC+GE+ +EE ++ S WAGGGGGGGGATYVF+++ G PL++AA
Sbjct: 788 QLIQKVCIGENNVIEEEIRVNRS-----VHEWAGGGGGGGGATYVFKMKDGVPVPLIIAA 842
Query: 233 GGGGRAYLRPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGDASETDN---LWA------ 283
GGGGRAY D PE+LEN S G G GAAGG DN LWA
Sbjct: 843 GGGGRAYGAKTD----TFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQE 898
Query: 284 -------------------------------DGEDGVSFIHPSSE-------------LF 299
G G +I ++ F
Sbjct: 899 GATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSF 958
Query: 300 LQPLA--------VTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDN 351
+ PL V E HGEV I+ +LNCSHC + +C E C C G LA D
Sbjct: 959 ISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDG 1018
Query: 352 VTCM--DLHKPPGPLVLMVAVVATSTLSLLMVC--GVLIL 387
V+C+ +P PL L+++VV ++ ++ L++ G++I+
Sbjct: 1019 VSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIV 1058
>gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens]
Length = 2347
Score = 256 bits (654), Expect = 5e-68
Identities = 123/274 (44%), Positives = 184/274 (67%), Gaps = 9/274 (3%)
Query: 412 SAQTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSF 471
+ +TL + + Q++++FL EA ++SKF H NI++ +G+ L P+ I+LELM GGD+ ++
Sbjct: 1978 AVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTY 2037
Query: 472 LRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPS--RV 529
LR +R L + DL+ L DI++GC YLE HFIHRD+AARNCL+S + R+
Sbjct: 2038 LRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRI 2097
Query: 530 AKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSL 589
KIGDFG+ARDIY+ YYR+ LLPV+WM PE+ ++GIFT+++D WSFG+L+WEI +L
Sbjct: 2098 VKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTL 2157
Query: 590 GYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQY 649
G+ PYP +N +VL++V GGR++PPR CP ++ +MTQCW EP+ RP+F I ++LQ
Sbjct: 2158 GHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQ- 2216
Query: 650 CTQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLE 683
+ + + + +E SG+ N S E
Sbjct: 2217 ------LFRNFFLNSIYKSRDEANNSGVINESFE 2244
>gi|31657140 insulin receptor-related receptor precursor [Homo
sapiens]
Length = 1297
Score = 234 bits (598), Expect = 2e-61
Identities = 123/297 (41%), Positives = 182/297 (61%), Gaps = 14/297 (4%)
Query: 405 GFPSQCYSAQTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMS 464
G S + +T+ EL SP++ ++FL EA ++ F+ ++VR +G+ + P L+++ELM+
Sbjct: 1004 GEESTPVALKTVNELASPRECIEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMT 1063
Query: 465 GGDMKSFLRHSRPHL----GQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCL 520
GD+KS LR RP G P P + +++Q+A +IA G YL N F+HRD+AARNC+
Sbjct: 1064 RGDLKSHLRSLRPEAENNPGLPQP-ALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCM 1122
Query: 521 LSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFG 580
+S KIGDFGM RD+Y YYR+G + LLPV+WM PE+ +GIFT+ +D WSFG
Sbjct: 1123 VS---QDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFG 1179
Query: 581 VLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSF 640
V+LWEI +L PY G +N++VL FV+ GG ++ GCP + +M++CWQ P LRPSF
Sbjct: 1180 VVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSF 1239
Query: 641 ASILERLQYCTQDPDVLNSLLPMELGPTPEEEGTSG-LGNRSLECLRPPQPQELSPE 696
IL+ +Q ++ S + +PE G G L E P P++ SP+
Sbjct: 1240 THILDSIQ-----EELRPSFRLLSFYYSPECRGARGSLPTTDAEPDSSPTPRDCSPQ 1291
>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
sapiens]
Length = 1367
Score = 230 bits (587), Expect = 3e-60
Identities = 121/317 (38%), Positives = 183/317 (57%), Gaps = 26/317 (8%)
Query: 407 PSQCYSAQTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGG 466
P + +T+ E S ++ ++FL EA ++ +F ++VR +G+ + P L+++ELM+ G
Sbjct: 1026 PETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRG 1085
Query: 467 DMKSFLRHSRPHLGQP---SPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSC 523
D+KS+LR RP + +P + ++Q+A +IA G YL N F+HRD+AARNC+++
Sbjct: 1086 DLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVA- 1144
Query: 524 AGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLL 583
KIGDFGM RDIY YYR+G + LLPV+WM PE+ +G+FT+ +D WSFGV+L
Sbjct: 1145 --EDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVL 1202
Query: 584 WEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASI 643
WEI +L PY G +N++VL FV+ GG +D P CP ++ +M CWQ+ P++RPSF I
Sbjct: 1203 WEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEI 1262
Query: 644 LERLQYCTQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGG 703
+ ++ + S E PE P+ +L PE ++S
Sbjct: 1263 ISSIKEEMEPGFREVSFYYSEENKLPE-----------------PEELDLEPENMES--- 1302
Query: 704 SPLGPWLSSGLKPLKSR 720
PL P SS PL R
Sbjct: 1303 VPLDPSASSSSLPLPDR 1319
>gi|119395738 insulin receptor isoform Short precursor [Homo sapiens]
Length = 1370
Score = 224 bits (571), Expect = 2e-58
Identities = 106/241 (43%), Positives = 159/241 (65%), Gaps = 8/241 (3%)
Query: 412 SAQTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSF 471
+ +T+ E S ++ ++FL EA ++ F ++VR +G+ + P L+++ELM+ GD+KS+
Sbjct: 1043 AVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSY 1102
Query: 472 LRHSRPHL----GQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPS 527
LR RP G+P P +++++Q+A +IA G YL F+HRD+AARNC+++
Sbjct: 1103 LRSLRPEAENNPGRPPP-TLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVA---HD 1158
Query: 528 RVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIF 587
KIGDFGM RDIY YYR+G + LLPV+WM PE+ +G+FT+ +D WSFGV+LWEI
Sbjct: 1159 FTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEIT 1218
Query: 588 SLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERL 647
SL PY G +N++VL FV+ GG +D P CP V +M CWQ P++RP+F I+ L
Sbjct: 1219 SLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL 1278
Query: 648 Q 648
+
Sbjct: 1279 K 1279
>gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]
Length = 1382
Score = 224 bits (571), Expect = 2e-58
Identities = 106/241 (43%), Positives = 159/241 (65%), Gaps = 8/241 (3%)
Query: 412 SAQTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSF 471
+ +T+ E S ++ ++FL EA ++ F ++VR +G+ + P L+++ELM+ GD+KS+
Sbjct: 1055 AVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSY 1114
Query: 472 LRHSRPHL----GQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPS 527
LR RP G+P P +++++Q+A +IA G YL F+HRD+AARNC+++
Sbjct: 1115 LRSLRPEAENNPGRPPP-TLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVA---HD 1170
Query: 528 RVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIF 587
KIGDFGM RDIY YYR+G + LLPV+WM PE+ +G+FT+ +D WSFGV+LWEI
Sbjct: 1171 FTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEIT 1230
Query: 588 SLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERL 647
SL PY G +N++VL FV+ GG +D P CP V +M CWQ P++RP+F I+ L
Sbjct: 1231 SLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL 1290
Query: 648 Q 648
+
Sbjct: 1291 K 1291
>gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isoform
1 [Homo sapiens]
Length = 790
Score = 209 bits (533), Expect = 6e-54
Identities = 114/271 (42%), Positives = 150/271 (55%), Gaps = 15/271 (5%)
Query: 402 CHRGFPSQ---CYSAQTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLI 458
CH P Q + + L E S DF EA +++ +HQ+IVR G+ P L+
Sbjct: 523 CHNLLPEQDKMLVAVKALKE-ASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLM 581
Query: 459 LLELMSGGDMKSFLRHSRPHLG--------QPSPLVMRDLLQLAQDIAQGCHYLEENHFI 510
+ E M GD+ FLR P P PL + LL +A +A G YL HF+
Sbjct: 582 VFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFV 641
Query: 511 HRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIF 570
HRD+A RNCL+ G V KIGDFGM+RDIY YYR G R +LP++WMPPE+ L F
Sbjct: 642 HRDLATRNCLV---GQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKF 698
Query: 571 TSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCW 630
T+++D WSFGV+LWEIF+ G P+ +N E +D + G ++ PR CP VY IM CW
Sbjct: 699 TTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCW 758
Query: 631 QHEPELRPSFASILERLQYCTQDPDVLNSLL 661
Q EP+ R S + RLQ Q P V +L
Sbjct: 759 QREPQQRHSIKDVHARLQALAQAPPVYLDVL 789
>gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isoform 2
[Homo sapiens]
Length = 796
Score = 209 bits (533), Expect = 6e-54
Identities = 114/271 (42%), Positives = 150/271 (55%), Gaps = 15/271 (5%)
Query: 402 CHRGFPSQ---CYSAQTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLI 458
CH P Q + + L E S DF EA +++ +HQ+IVR G+ P L+
Sbjct: 529 CHNLLPEQDKMLVAVKALKE-ASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLM 587
Query: 459 LLELMSGGDMKSFLRHSRPHLG--------QPSPLVMRDLLQLAQDIAQGCHYLEENHFI 510
+ E M GD+ FLR P P PL + LL +A +A G YL HF+
Sbjct: 588 VFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFV 647
Query: 511 HRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIF 570
HRD+A RNCL+ G V KIGDFGM+RDIY YYR G R +LP++WMPPE+ L F
Sbjct: 648 HRDLATRNCLV---GQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKF 704
Query: 571 TSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCW 630
T+++D WSFGV+LWEIF+ G P+ +N E +D + G ++ PR CP VY IM CW
Sbjct: 705 TTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCW 764
Query: 631 QHEPELRPSFASILERLQYCTQDPDVLNSLL 661
Q EP+ R S + RLQ Q P V +L
Sbjct: 765 QREPQQRHSIKDVHARLQALAQAPPVYLDVL 795
>gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isoform
3 [Homo sapiens]
Length = 760
Score = 209 bits (533), Expect = 6e-54
Identities = 114/271 (42%), Positives = 150/271 (55%), Gaps = 15/271 (5%)
Query: 402 CHRGFPSQ---CYSAQTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLI 458
CH P Q + + L E S DF EA +++ +HQ+IVR G+ P L+
Sbjct: 493 CHNLLPEQDKMLVAVKALKE-ASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLM 551
Query: 459 LLELMSGGDMKSFLRHSRPHLG--------QPSPLVMRDLLQLAQDIAQGCHYLEENHFI 510
+ E M GD+ FLR P P PL + LL +A +A G YL HF+
Sbjct: 552 VFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFV 611
Query: 511 HRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIF 570
HRD+A RNCL+ G V KIGDFGM+RDIY YYR G R +LP++WMPPE+ L F
Sbjct: 612 HRDLATRNCLV---GQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKF 668
Query: 571 TSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCW 630
T+++D WSFGV+LWEIF+ G P+ +N E +D + G ++ PR CP VY IM CW
Sbjct: 669 TTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCW 728
Query: 631 QHEPELRPSFASILERLQYCTQDPDVLNSLL 661
Q EP+ R S + RLQ Q P V +L
Sbjct: 729 QREPQQRHSIKDVHARLQALAQAPPVYLDVL 759
>gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens]
Length = 694
Score = 197 bits (501), Expect = 3e-50
Identities = 105/235 (44%), Positives = 143/235 (60%), Gaps = 13/235 (5%)
Query: 414 QTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLR 473
+TLP P + FL EA I+ ++ H NIVR +G+ + P I++EL+ GGD +FLR
Sbjct: 466 ETLP----PDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLR 521
Query: 474 HSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIG 533
+ + L ++ LLQ+ D A G YLE IHRD+AARNCL++ V KI
Sbjct: 522 T------EGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVT---EKNVLKIS 572
Query: 534 DFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMP 593
DFGM+R+ Y G +PVKW PEA G ++S++D WSFG+LLWE FSLG P
Sbjct: 573 DFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASP 632
Query: 594 YPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQ 648
YP +NQ+ +FV GGR+ P CP V+R+M QCW +EP RPSF++I + LQ
Sbjct: 633 YPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQ 687
>gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens]
Length = 752
Score = 197 bits (501), Expect = 3e-50
Identities = 105/235 (44%), Positives = 143/235 (60%), Gaps = 13/235 (5%)
Query: 414 QTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLR 473
+TLP P + FL EA I+ ++ H NIVR +G+ + P I++EL+ GGD +FLR
Sbjct: 524 ETLP----PDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLR 579
Query: 474 HSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIG 533
+ + L ++ LLQ+ D A G YLE IHRD+AARNCL++ V KI
Sbjct: 580 T------EGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVT---EKNVLKIS 630
Query: 534 DFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMP 593
DFGM+R+ Y G +PVKW PEA G ++S++D WSFG+LLWE FSLG P
Sbjct: 631 DFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASP 690
Query: 594 YPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQ 648
YP +NQ+ +FV GGR+ P CP V+R+M QCW +EP RPSF++I + LQ
Sbjct: 691 YPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQ 745
>gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens]
Length = 764
Score = 197 bits (501), Expect = 3e-50
Identities = 105/235 (44%), Positives = 143/235 (60%), Gaps = 13/235 (5%)
Query: 414 QTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLR 473
+TLP P + FL EA I+ ++ H NIVR +G+ + P I++EL+ GGD +FLR
Sbjct: 536 ETLP----PDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLR 591
Query: 474 HSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIG 533
+ + L ++ LLQ+ D A G YLE IHRD+AARNCL++ V KI
Sbjct: 592 T------EGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVT---EKNVLKIS 642
Query: 534 DFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMP 593
DFGM+R+ Y G +PVKW PEA G ++S++D WSFG+LLWE FSLG P
Sbjct: 643 DFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASP 702
Query: 594 YPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQ 648
YP +NQ+ +FV GGR+ P CP V+R+M QCW +EP RPSF++I + LQ
Sbjct: 703 YPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQ 757
>gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens]
Length = 822
Score = 197 bits (501), Expect = 3e-50
Identities = 105/235 (44%), Positives = 143/235 (60%), Gaps = 13/235 (5%)
Query: 414 QTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLR 473
+TLP P + FL EA I+ ++ H NIVR +G+ + P I++EL+ GGD +FLR
Sbjct: 594 ETLP----PDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLR 649
Query: 474 HSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIG 533
+ + L ++ LLQ+ D A G YLE IHRD+AARNCL++ V KI
Sbjct: 650 T------EGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVT---EKNVLKIS 700
Query: 534 DFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMP 593
DFGM+R+ Y G +PVKW PEA G ++S++D WSFG+LLWE FSLG P
Sbjct: 701 DFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASP 760
Query: 594 YPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQ 648
YP +NQ+ +FV GGR+ P CP V+R+M QCW +EP RPSF++I + LQ
Sbjct: 761 YPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQ 815
>gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isoform
c precursor [Homo sapiens]
Length = 822
Score = 195 bits (496), Expect = 1e-49
Identities = 100/265 (37%), Positives = 147/265 (55%), Gaps = 31/265 (11%)
Query: 406 FPSQCYSAQTLPELCSPQDEL----------------DFLMEALIISKFRHQNIVRCVGL 449
F ++CY+ LC QD++ DF EA +++ +H++IV+ G+
Sbjct: 553 FLAECYN------LCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGV 606
Query: 450 SLRATPRLILLELMSGGDMKSFLRHSRPHL------GQPSPLVMRDLLQLAQDIAQGCHY 503
+ P +++ E M GD+ FLR P P+ L +L +AQ IA G Y
Sbjct: 607 CVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVY 666
Query: 504 LEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPE 563
L HF+HRD+A RNCL+ G + + KIGDFGM+RD+Y YYR G +LP++WMPPE
Sbjct: 667 LASQHFVHRDLATRNCLV---GENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPE 723
Query: 564 AFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVY 623
+ + FT+++D WS GV+LWEIF+ G P+ +N EV++ + G + PR CP VY
Sbjct: 724 SIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVY 783
Query: 624 RIMTQCWQHEPELRPSFASILERLQ 648
+M CWQ EP +R + I LQ
Sbjct: 784 ELMLGCWQREPHMRKNIKGIHTLLQ 808
>gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isoform
a precursor [Homo sapiens]
Length = 838
Score = 195 bits (496), Expect = 1e-49
Identities = 100/265 (37%), Positives = 147/265 (55%), Gaps = 31/265 (11%)
Query: 406 FPSQCYSAQTLPELCSPQDEL----------------DFLMEALIISKFRHQNIVRCVGL 449
F ++CY+ LC QD++ DF EA +++ +H++IV+ G+
Sbjct: 569 FLAECYN------LCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGV 622
Query: 450 SLRATPRLILLELMSGGDMKSFLRHSRPHL------GQPSPLVMRDLLQLAQDIAQGCHY 503
+ P +++ E M GD+ FLR P P+ L +L +AQ IA G Y
Sbjct: 623 CVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVY 682
Query: 504 LEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPE 563
L HF+HRD+A RNCL+ G + + KIGDFGM+RD+Y YYR G +LP++WMPPE
Sbjct: 683 LASQHFVHRDLATRNCLV---GENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPE 739
Query: 564 AFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVY 623
+ + FT+++D WS GV+LWEIF+ G P+ +N EV++ + G + PR CP VY
Sbjct: 740 SIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVY 799
Query: 624 RIMTQCWQHEPELRPSFASILERLQ 648
+M CWQ EP +R + I LQ
Sbjct: 800 ELMLGCWQREPHMRKNIKGIHTLLQ 824
>gi|21536468 AXL receptor tyrosine kinase isoform 2 [Homo sapiens]
Length = 885
Score = 191 bits (486), Expect = 2e-48
Identities = 103/271 (38%), Positives = 157/271 (57%), Gaps = 18/271 (6%)
Query: 419 LCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPR------LILLELMSGGDMKSFL 472
+C+ + DFL EA+ + +F H N++R +G+ + + R +++L M GD+ SFL
Sbjct: 564 ICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFL 623
Query: 473 RHSRPHLG-QPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAK 531
+SR LG QP L + L++ DIA G YL FIHRD+AARNC+L+ +
Sbjct: 624 LYSR--LGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLN---ENMSVC 678
Query: 532 IGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGY 591
+ DFG+++ IY YYR+G A +PVKW+ E+ + ++TSK+D WSFGV +WEI + G
Sbjct: 679 VADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQ 738
Query: 592 MPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYC- 650
PYPG N E+ D++ G R+ P C +Y +M++CW+ P+ RPSF + E L+
Sbjct: 739 TPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTL 798
Query: 651 -----TQDPDVLNSLLPMELGPTPEEEGTSG 676
Q+PD + + E G PE G +G
Sbjct: 799 KALPPAQEPDEILYVNMDEGGGYPEPPGAAG 829
>gi|21536466 AXL receptor tyrosine kinase isoform 1 [Homo sapiens]
Length = 894
Score = 191 bits (486), Expect = 2e-48
Identities = 103/271 (38%), Positives = 157/271 (57%), Gaps = 18/271 (6%)
Query: 419 LCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPR------LILLELMSGGDMKSFL 472
+C+ + DFL EA+ + +F H N++R +G+ + + R +++L M GD+ SFL
Sbjct: 573 ICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFL 632
Query: 473 RHSRPHLG-QPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAK 531
+SR LG QP L + L++ DIA G YL FIHRD+AARNC+L+ +
Sbjct: 633 LYSR--LGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLN---ENMSVC 687
Query: 532 IGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGY 591
+ DFG+++ IY YYR+G A +PVKW+ E+ + ++TSK+D WSFGV +WEI + G
Sbjct: 688 VADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQ 747
Query: 592 MPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYC- 650
PYPG N E+ D++ G R+ P C +Y +M++CW+ P+ RPSF + E L+
Sbjct: 748 TPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTL 807
Query: 651 -----TQDPDVLNSLLPMELGPTPEEEGTSG 676
Q+PD + + E G PE G +G
Sbjct: 808 KALPPAQEPDEILYVNMDEGGGYPEPPGAAG 838
>gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [Homo
sapiens]
Length = 1070
Score = 189 bits (481), Expect = 6e-48
Identities = 96/234 (41%), Positives = 140/234 (59%), Gaps = 7/234 (2%)
Query: 423 QDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLR--HSRPHLG 480
Q +LDF E + K H N+VR +GL A P ++LE + GD+K FLR S+
Sbjct: 838 QQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKL 897
Query: 481 QPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARD 540
+ PL + + L +A G +L N F+H+D+AARNCL+S R K+ G+++D
Sbjct: 898 KSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSA---QRQVKVSALGLSKD 954
Query: 541 IYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQ 600
+Y + YY +A +P++WM PEA LEG F++K+D W+FGVL+WE+F+ G MP+ G+ +
Sbjct: 955 VYNSEYYHFR-QAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADD 1013
Query: 601 EVL-DFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQD 653
EVL D G R+ P GCP +YR+M +CW P+ RPSF+ I L T D
Sbjct: 1014 EVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVD 1067
>gi|22902130 PTK7 protein tyrosine kinase 7 isoform d precursor [Homo
sapiens]
Length = 1014
Score = 189 bits (481), Expect = 6e-48
Identities = 96/234 (41%), Positives = 140/234 (59%), Gaps = 7/234 (2%)
Query: 423 QDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLR--HSRPHLG 480
Q +LDF E + K H N+VR +GL A P ++LE + GD+K FLR S+
Sbjct: 782 QQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKL 841
Query: 481 QPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARD 540
+ PL + + L +A G +L N F+H+D+AARNCL+S R K+ G+++D
Sbjct: 842 KSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSA---QRQVKVSALGLSKD 898
Query: 541 IYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQ 600
+Y + YY +A +P++WM PEA LEG F++K+D W+FGVL+WE+F+ G MP+ G+ +
Sbjct: 899 VYNSEYYHFR-QAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADD 957
Query: 601 EVL-DFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQD 653
EVL D G R+ P GCP +YR+M +CW P+ RPSF+ I L T D
Sbjct: 958 EVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVD 1011
>gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor
[Homo sapiens]
Length = 940
Score = 189 bits (481), Expect = 6e-48
Identities = 96/234 (41%), Positives = 140/234 (59%), Gaps = 7/234 (2%)
Query: 423 QDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLR--HSRPHLG 480
Q +LDF E + K H N+VR +GL A P ++LE + GD+K FLR S+
Sbjct: 708 QQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKL 767
Query: 481 QPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARD 540
+ PL + + L +A G +L N F+H+D+AARNCL+S R K+ G+++D
Sbjct: 768 KSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSA---QRQVKVSALGLSKD 824
Query: 541 IYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQ 600
+Y + YY +A +P++WM PEA LEG F++K+D W+FGVL+WE+F+ G MP+ G+ +
Sbjct: 825 VYNSEYYHFR-QAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADD 883
Query: 601 EVL-DFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQD 653
EVL D G R+ P GCP +YR+M +CW P+ RPSF+ I L T D
Sbjct: 884 EVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVD 937
>gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor [Homo
sapiens]
Length = 1030
Score = 189 bits (481), Expect = 6e-48
Identities = 96/234 (41%), Positives = 140/234 (59%), Gaps = 7/234 (2%)
Query: 423 QDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLR--HSRPHLG 480
Q +LDF E + K H N+VR +GL A P ++LE + GD+K FLR S+
Sbjct: 798 QQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKL 857
Query: 481 QPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARD 540
+ PL + + L +A G +L N F+H+D+AARNCL+S R K+ G+++D
Sbjct: 858 KSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSA---QRQVKVSALGLSKD 914
Query: 541 IYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQ 600
+Y + YY +A +P++WM PEA LEG F++K+D W+FGVL+WE+F+ G MP+ G+ +
Sbjct: 915 VYNSEYYHFR-QAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADD 973
Query: 601 EVL-DFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQD 653
EVL D G R+ P GCP +YR+M +CW P+ RPSF+ I L T D
Sbjct: 974 EVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVD 1027
>gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens]
Length = 869
Score = 188 bits (478), Expect = 1e-47
Identities = 98/261 (37%), Positives = 144/261 (55%), Gaps = 23/261 (8%)
Query: 407 PSQCYSAQTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGG 466
P + + L E S + DF EA ++++F + NIV+ +G+ P +L E M+ G
Sbjct: 602 PFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYG 661
Query: 467 DMKSFLRHSRPHL-----------------GQPSPLVMRDLLQLAQDIAQGCHYLEENHF 509
D+ FLR PH P PL + L +A+ +A G YL E F
Sbjct: 662 DLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKF 721
Query: 510 IHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGI 569
+HRD+A RNCL+ G + V KI DFG++R+IY A YY+ + +P++WMPPE+
Sbjct: 722 VHRDLATRNCLV---GENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNR 778
Query: 570 FTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQC 629
+T+++D W++GV+LWEIFS G PY G ++EV+ +V G + P CP +Y +M C
Sbjct: 779 YTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLC 838
Query: 630 WQHEPELRPSFAS---ILERL 647
W P RPSF S ILER+
Sbjct: 839 WSKLPADRPSFTSIHRILERM 859
>gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isoform
b precursor [Homo sapiens]
Length = 825
Score = 188 bits (477), Expect = 2e-47
Identities = 94/230 (40%), Positives = 137/230 (59%), Gaps = 12/230 (5%)
Query: 427 DFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHL-----GQ 481
DF EA +++ +H++IV+ G+ P +++ E M GD+ FLR P GQ
Sbjct: 584 DFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQ 643
Query: 482 P----SPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGM 537
P L + +L +A IA G YL HF+HRD+A RNCL+ G + + KIGDFGM
Sbjct: 644 PRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLV---GANLLVKIGDFGM 700
Query: 538 ARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGR 597
+RD+Y YYR G +LP++WMPPE+ + FT+++D WSFGV+LWEIF+ G P+
Sbjct: 701 SRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQL 760
Query: 598 TNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERL 647
+N EV++ + G ++ PR CP VY +M CWQ EP+ R + I + L
Sbjct: 761 SNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKIL 810
>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
Length = 822
Score = 187 bits (475), Expect = 3e-47
Identities = 97/227 (42%), Positives = 141/227 (62%), Gaps = 11/227 (4%)
Query: 422 PQD-ELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLG 480
PQ+ ++ FL EA I+ ++ H NIV+ +G+ + P I++EL+SGGD +FLR +
Sbjct: 598 PQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKK---- 653
Query: 481 QPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARD 540
L ++ L++ + D A G YLE + IHRD+AARNCL+ G + V KI DFGM+R
Sbjct: 654 --DELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLV---GENNVLKISDFGMSRQ 708
Query: 541 IYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQ 600
Y G + +P+KW PEA G ++S++D WSFG+LLWE FSLG PYPG TNQ
Sbjct: 709 EDGGVYSSSGLKQ-IPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQ 767
Query: 601 EVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERL 647
+ + V G RM P+ CP + +IM +CW ++PE RP F+ + + L
Sbjct: 768 QAREQVERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKEL 814
>gi|134152725 receptor tyrosine kinase-like orphan receptor 1
isoform 1 [Homo sapiens]
Length = 937
Score = 183 bits (464), Expect = 6e-46
Identities = 99/251 (39%), Positives = 140/251 (55%), Gaps = 13/251 (5%)
Query: 408 SQCYSAQTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGD 467
+Q + +TL + +PQ +F EA ++++ H NIV +G + P +L E ++ GD
Sbjct: 500 AQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGD 559
Query: 468 MKSFLRHSRPHLGQ----------PSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAAR 517
+ FL PH S L D L +A IA G YL + F+H+D+AAR
Sbjct: 560 LHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAAR 619
Query: 518 NCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSW 577
N L+ G KI D G++R+IY A YYR ++LLP++WMPPEA + G F+S +D W
Sbjct: 620 NILI---GEQLHVKISDLGLSREIYSADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSDIW 676
Query: 578 SFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELR 637
SFGV+LWEIFS G PY G +NQEV++ V + CP +Y +MT+CW P R
Sbjct: 677 SFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRR 736
Query: 638 PSFASILERLQ 648
P F I RL+
Sbjct: 737 PRFKDIHVRLR 747
>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
Length = 631
Score = 181 bits (458), Expect = 3e-45
Identities = 96/223 (43%), Positives = 129/223 (57%), Gaps = 10/223 (4%)
Query: 425 ELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLGQPSP 484
E DF+ EA ++ K H +V+ G+ + P I+ E M G + +FLR + H +
Sbjct: 407 EEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDV- 465
Query: 485 LVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRA 544
LL + QD+ +G YLE N FIHRD+AARNCL+S AG V K+ DFGMAR +
Sbjct: 466 -----LLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAG---VVKVSDFGMARYVLD- 516
Query: 545 SYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLD 604
Y A PVKW PPE F F+SK+D WSFGVL+WE+F+ G MP+ TN EV+
Sbjct: 517 DQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVT 576
Query: 605 FVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERL 647
V G R+ P+ VY +M +CWQ +PE RPSF +L +
Sbjct: 577 MVTRGHRLYQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTI 619
>gi|27597078 TYRO3 protein tyrosine kinase [Homo sapiens]
Length = 890
Score = 181 bits (458), Expect = 3e-45
Identities = 97/267 (36%), Positives = 154/267 (57%), Gaps = 13/267 (4%)
Query: 418 ELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPR------LILLELMSGGDMKSF 471
++ + D +FL EA + +F H ++ + VG+SLR+ + +++L M GD+ +F
Sbjct: 555 DIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAF 614
Query: 472 LRHSRPHLGQ-PSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVA 530
L SR +G+ P L ++ L++ DIA G YL +FIHRD+AARNC+L+
Sbjct: 615 LLASR--IGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLA---EDMTV 669
Query: 531 KIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLG 590
+ DFG++R IY YYR+G + LPVKW+ E+ + ++T ++D W+FGV +WEI + G
Sbjct: 670 CVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRG 729
Query: 591 YMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYC 650
PY G N E+ ++++GG R+ P C VY +M QCW +P+ RPSF + L+
Sbjct: 730 QTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENI 789
Query: 651 TQDPDVLN-SLLPMELGPTPEEEGTSG 676
VL+ S P+ + EE T+G
Sbjct: 790 LGQLSVLSASQDPLYINIERAEEPTAG 816
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.138 0.440
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,229,149
Number of Sequences: 37866
Number of extensions: 2094118
Number of successful extensions: 14090
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 374
Number of HSP's successfully gapped in prelim test: 493
Number of HSP's that attempted gapping in prelim test: 11188
Number of HSP's gapped (non-prelim): 1991
length of query: 734
length of database: 18,247,518
effective HSP length: 110
effective length of query: 624
effective length of database: 14,082,258
effective search space: 8787328992
effective search space used: 8787328992
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.