Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 208609985
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|208609985 SH2 domain containing 3A [Homo sapiens]
(576 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|208609985 SH2 domain containing 3A [Homo sapiens] 1167 0.0
gi|4502371 breast cancer antiestrogen resistance 3 [Homo sapiens] 363 e-100
gi|216547801 SH2 domain containing 3C isoform e [Homo sapiens] 315 6e-86
gi|216547790 SH2 domain containing 3C isoform d [Homo sapiens] 315 6e-86
gi|216547763 SH2 domain containing 3C isoform b [Homo sapiens] 315 6e-86
gi|41281821 SH2 domain containing 3C isoform a [Homo sapiens] 315 6e-86
gi|216547779 SH2 domain containing 3C isoform c [Homo sapiens] 255 9e-68
gi|216547769 SH2 domain containing 3C isoform c [Homo sapiens] 255 9e-68
gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens] 65 2e-10
gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens] 65 2e-10
gi|194239668 SHC (Src homology 2 domain containing) transforming... 64 4e-10
gi|194239664 SHC (Src homology 2 domain containing) transforming... 64 4e-10
gi|194239662 SHC (Src homology 2 domain containing) transforming... 64 4e-10
gi|32261324 SHC (Src homology 2 domain containing) transforming ... 64 4e-10
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens] 61 3e-09
gi|224586793 src homology 2 domain-containing transforming prote... 55 2e-07
gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo ... 54 3e-07
gi|169790811 SHC (Src homology 2 domain containing) transforming... 54 3e-07
gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a ... 50 7e-06
gi|41327710 v-crk sarcoma virus CT10 oncogene homolog isoform b ... 50 7e-06
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 49 1e-05
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 49 1e-05
gi|222446609 rai-like protein [Homo sapiens] 49 2e-05
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 49 2e-05
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 49 2e-05
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 49 2e-05
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 49 2e-05
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 49 2e-05
gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens] 48 2e-05
gi|5729856 GRB2-related adaptor protein [Homo sapiens] 48 3e-05
>gi|208609985 SH2 domain containing 3A [Homo sapiens]
Length = 576
Score = 1167 bits (3019), Expect = 0.0
Identities = 576/576 (100%), Positives = 576/576 (100%)
Query: 1 MQVPQDGEDLAGQPWYHGLLSRQKAEALLQQNGDFLVRASGSRGGNPVISCRWRGSALHF 60
MQVPQDGEDLAGQPWYHGLLSRQKAEALLQQNGDFLVRASGSRGGNPVISCRWRGSALHF
Sbjct: 1 MQVPQDGEDLAGQPWYHGLLSRQKAEALLQQNGDFLVRASGSRGGNPVISCRWRGSALHF 60
Query: 61 EVFRVALRPRPGRPTALFQLEDEQFPSIPALVHSYMTGRRPLSQATGAVVSRPVTWQGPL 120
EVFRVALRPRPGRPTALFQLEDEQFPSIPALVHSYMTGRRPLSQATGAVVSRPVTWQGPL
Sbjct: 61 EVFRVALRPRPGRPTALFQLEDEQFPSIPALVHSYMTGRRPLSQATGAVVSRPVTWQGPL 120
Query: 121 RRSFSEDTLMDGPARIEPLRARKWSNSQPADLAHMGRSREDPAGMEASTMPISALPRTSS 180
RRSFSEDTLMDGPARIEPLRARKWSNSQPADLAHMGRSREDPAGMEASTMPISALPRTSS
Sbjct: 121 RRSFSEDTLMDGPARIEPLRARKWSNSQPADLAHMGRSREDPAGMEASTMPISALPRTSS 180
Query: 181 DPVLLKAPAPLGTVADSLRASDGQLQAKAPTKPPRTPSFELPDASERPPTYCELVPRVPS 240
DPVLLKAPAPLGTVADSLRASDGQLQAKAPTKPPRTPSFELPDASERPPTYCELVPRVPS
Sbjct: 181 DPVLLKAPAPLGTVADSLRASDGQLQAKAPTKPPRTPSFELPDASERPPTYCELVPRVPS 240
Query: 241 VQGTSPSQSCPEPEAPWWEAEEDEEEENRCFTRPQAEISFCPHDAPSCLLGPQNRPLEPQ 300
VQGTSPSQSCPEPEAPWWEAEEDEEEENRCFTRPQAEISFCPHDAPSCLLGPQNRPLEPQ
Sbjct: 241 VQGTSPSQSCPEPEAPWWEAEEDEEEENRCFTRPQAEISFCPHDAPSCLLGPQNRPLEPQ 300
Query: 301 VLHTLRGLFLEHHPGSTALHLLLVDCQATGLLGVTRDQRGNMGVSSGLELLTLPHGHHLR 360
VLHTLRGLFLEHHPGSTALHLLLVDCQATGLLGVTRDQRGNMGVSSGLELLTLPHGHHLR
Sbjct: 301 VLHTLRGLFLEHHPGSTALHLLLVDCQATGLLGVTRDQRGNMGVSSGLELLTLPHGHHLR 360
Query: 361 LELLERHQTLALAGALAVLGCSGPLEERAAALRGLVELALALRPGAAGDLPGLAAVMGAL 420
LELLERHQTLALAGALAVLGCSGPLEERAAALRGLVELALALRPGAAGDLPGLAAVMGAL
Sbjct: 361 LELLERHQTLALAGALAVLGCSGPLEERAAALRGLVELALALRPGAAGDLPGLAAVMGAL 420
Query: 421 LMPQVSRLEHTWRQLRRSHTEAALAFEQELKPLMRALDEGAGPCDPGEVALPHVAPMVRL 480
LMPQVSRLEHTWRQLRRSHTEAALAFEQELKPLMRALDEGAGPCDPGEVALPHVAPMVRL
Sbjct: 421 LMPQVSRLEHTWRQLRRSHTEAALAFEQELKPLMRALDEGAGPCDPGEVALPHVAPMVRL 480
Query: 481 LEGEEVAGPLDESCERLLRTLHGARHMVRDAPKFRKVAAQRLRGFRPNPELREALTTGFV 540
LEGEEVAGPLDESCERLLRTLHGARHMVRDAPKFRKVAAQRLRGFRPNPELREALTTGFV
Sbjct: 481 LEGEEVAGPLDESCERLLRTLHGARHMVRDAPKFRKVAAQRLRGFRPNPELREALTTGFV 540
Query: 541 RRLLWGSRGAGAPRAERFEKFQRVLGVLSQRLEPDR 576
RRLLWGSRGAGAPRAERFEKFQRVLGVLSQRLEPDR
Sbjct: 541 RRLLWGSRGAGAPRAERFEKFQRVLGVLSQRLEPDR 576
>gi|4502371 breast cancer antiestrogen resistance 3 [Homo sapiens]
Length = 825
Score = 363 bits (933), Expect = e-100
Identities = 244/674 (36%), Positives = 348/674 (51%), Gaps = 110/674 (16%)
Query: 8 EDLAGQPWYHGLLSRQKAEALLQQNGDFLVRASGSRGGNPVISCRWRGSALHFEVFRVAL 67
EDL WYHG + RQ +E L+Q++GDFLVR S S GN V++C+W+ A HF++ R L
Sbjct: 147 EDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVL 206
Query: 68 RPRPGRPTALFQLEDEQFPSIPALVHSYMTGRRPLSQATGAVVSRPVTWQGPLR------ 121
R +Q E E F SIP LV Y+ RRP+SQ +GA++ +P+ PLR
Sbjct: 207 RLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLRCLEEHY 266
Query: 122 ----RSFSEDTLMDGPARIEP---------------------LRARKWSNSQPADLAHMG 156
E +L G + LR ++ S SQPA L HM
Sbjct: 267 GTSPGQAREGSLTKGRPDVAKRLSLTMGGVQAREQNLPRGNLLRNKEKSGSQPACLDHMQ 326
Query: 157 RSRE--------------------DPAGMEASTMPISALPRTSSDPVLLKAPAPLGTVA- 195
R +G++ S P S + RT S+P L +PA + V+
Sbjct: 327 DRRALSLKAHQSESYLPIGCKLPPQSSGVDTSPCPNSPVFRTGSEPAL--SPAVVRRVSS 384
Query: 196 -----DSLRASDGQLQAKAPTKPPRTPSFELPDASER----PPTYCELVP---------- 236
++LR SD QL K P KP + P ++P + YCEL P
Sbjct: 385 DARAGEALRGSDSQLCPKPPPKPCKVPFLKVPSSPSAWLNSEANYCELNPAFATGCGRGA 444
Query: 237 RVPS-VQG------TSPSQSCPEP---------------EAPWWEAEEDEEE---ENRCF 271
++PS QG T+ P P E PW A E+ + F
Sbjct: 445 KLPSCAQGSHTELLTAKQNEAPGPRNSGVNYLILDDDDRERPWEPAAAQMEKGQWDKGEF 504
Query: 272 TRPQAEI--SFCPHDAPSCLLGPQNRPLEPQVLHTLRGLFLEHHPGSTALHLLLVDCQAT 329
P E SF P++ S L P+N+PLE +L + LF + P A H+L +DC+
Sbjct: 505 VTPLLETVSSFRPNEFESKFLPPENKPLETAMLKRAKELFTNNDPKVIAQHVLSMDCRVA 564
Query: 330 GLLGVTRDQRGNMGVSSGLELLTLPHGHHLRLELLERHQTLALAGALAVLGCSGPLEERA 389
+LGV+ + R NMGVSSGLEL+TLPHGH LRL+++ERH T+A+ A+ +LGC+G LE+RA
Sbjct: 565 RILGVSEEMRRNMGVSSGLELITLPHGHQLRLDIIERHNTMAIGIAVDILGCTGTLEDRA 624
Query: 390 AALRGLVELALALRPGAAGDLPGLAAVMGALLMPQVSRLEHTWRQLRRSHTEAALAFEQE 449
A L ++++A+ L+ + GDL +A+M AL MPQ++RLE TW LR +T+ A+ +E++
Sbjct: 625 ATLSKIIQVAVELK-DSMGDLYSFSALMKALEMPQITRLEKTWTALRHQYTQTAILYEKQ 683
Query: 450 LKPLMRALDEG-AGPC-DPGEVALPHVAPMVRLL-------EGEEVAGPLDESCERLLRT 500
LKP + L EG C P V++P + P+V L+ EG ++ D+SCE +L
Sbjct: 684 LKPFSKLLHEGRESTCVPPNNVSVPLLMPLVTLMERQAVTFEGTDMWEKNDQSCEIMLNH 743
Query: 501 LHGARHMVRDAPKFRKVAAQRLRGFRPNPELREALTTGFVRRLLWGSRGAGAPRAERFEK 560
L AR M A +R A + L GF+P+ E+ E T F RLLWGS+GA + ER+EK
Sbjct: 744 LATARFMAEAADSYRMNAERILAGFQPDEEMNEICKTEFQMRLLWGSKGAQVNQTERYEK 803
Query: 561 FQRVLGVLSQRLEP 574
F ++L LS++LEP
Sbjct: 804 FNQILTALSRKLEP 817
>gi|216547801 SH2 domain containing 3C isoform e [Homo sapiens]
Length = 700
Score = 315 bits (808), Expect = 6e-86
Identities = 219/646 (33%), Positives = 320/646 (49%), Gaps = 86/646 (13%)
Query: 9 DLAGQPWYHGLLSRQKAEALLQQNGDFLVRASGSRGGNPVISCRWRGSALHFEVFRVALR 68
DL WYHG + R+ +E L+Q+NGDFL+R S + G+ V++CRWR ALHF++ +V ++
Sbjct: 54 DLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVK 113
Query: 69 PRPGRPTALFQLEDEQFPSIPALVHSYMTGRRPLSQATGAVV------------------ 110
+ E E F +PALV ++ R+ +S+ +GA++
Sbjct: 114 AGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYG 173
Query: 111 --------SRPVTWQGPL-----RRSFS--------EDTLMDG-------PARIEPLRAR 142
+ PV+ GP RRS + + T DG P + +R+
Sbjct: 174 LGQGSSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSC 233
Query: 143 KWSNSQPADL----------------AHMGRSREDPAGMEASTMPISALPRTSSDPVLLK 186
S Q DL + + R PA A+ +P S + R SS+P L
Sbjct: 234 ALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCP 293
Query: 187 APAPL--GTVADSLRASDGQLQAKAPTKPPRTPSFELPDASERPPTYCELVPRVPSVQGT 244
AP G S KA P + S+ PD+ YC+L P V +
Sbjct: 294 GSAPKTHGESDKGPHTSPSHTLGKASPSPSLS-SYSDPDSGH----YCQLQPPVRGSREW 348
Query: 245 SPSQSCPEPEAPWWEAEEDEEEEN-------RCFTRPQAEI--SFCPHDAPSCLLGPQNR 295
+ +++ + + E ++ E + FT P E+ SF P S L+ NR
Sbjct: 349 AATETSSQQARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNR 408
Query: 296 PLEPQVLHTLRGLFLEHHPGSTALHLLLVDCQATGLLGVTRDQRGNMGVSSGLELLTLPH 355
PLE +L ++ L E + A H+ VDC +LGVT++ + MGV G+ELLTLPH
Sbjct: 409 PLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPH 468
Query: 356 GHHLRLELLERHQTLALAGALAVLGCSGPLEERAAALRGLVELALALRPGAAGDLPGLAA 415
G LRL+LLER T+++ A+ +LGC+G EERAA L ++LA LR G G++ AA
Sbjct: 469 GRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELR-GTMGNMFSFAA 527
Query: 416 VMGALLMPQVSRLEHTWRQLRRSHTEAALAFEQELKPLMRALDEGAGPCDPGEVALPHVA 475
VMGAL M Q+SRLE TW LR+ HTE A+ +E++LKP +++L+EG PHV
Sbjct: 528 VMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVL 587
Query: 476 PMVRLL-------EGEEVAGPLDESCERLLRTLHGARHMVRDAPKFRKVAAQRLRGFRPN 528
P++ LL EG E G + E +L L AR + + A +L+GF+
Sbjct: 588 PLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQAR 647
Query: 529 PELREALTTGFVRRLLWGSRGAGAPRAERFEKFQRVLGVLSQRLEP 574
PEL E +T F RLLWGS+GA + +A R+EKF +VL LS +LEP
Sbjct: 648 PELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEP 693
>gi|216547790 SH2 domain containing 3C isoform d [Homo sapiens]
Length = 702
Score = 315 bits (808), Expect = 6e-86
Identities = 219/646 (33%), Positives = 320/646 (49%), Gaps = 86/646 (13%)
Query: 9 DLAGQPWYHGLLSRQKAEALLQQNGDFLVRASGSRGGNPVISCRWRGSALHFEVFRVALR 68
DL WYHG + R+ +E L+Q+NGDFL+R S + G+ V++CRWR ALHF++ +V ++
Sbjct: 56 DLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVK 115
Query: 69 PRPGRPTALFQLEDEQFPSIPALVHSYMTGRRPLSQATGAVV------------------ 110
+ E E F +PALV ++ R+ +S+ +GA++
Sbjct: 116 AGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYG 175
Query: 111 --------SRPVTWQGPL-----RRSFS--------EDTLMDG-------PARIEPLRAR 142
+ PV+ GP RRS + + T DG P + +R+
Sbjct: 176 LGQGSSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSC 235
Query: 143 KWSNSQPADL----------------AHMGRSREDPAGMEASTMPISALPRTSSDPVLLK 186
S Q DL + + R PA A+ +P S + R SS+P L
Sbjct: 236 ALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCP 295
Query: 187 APAPL--GTVADSLRASDGQLQAKAPTKPPRTPSFELPDASERPPTYCELVPRVPSVQGT 244
AP G S KA P + S+ PD+ YC+L P V +
Sbjct: 296 GSAPKTHGESDKGPHTSPSHTLGKASPSPSLS-SYSDPDSGH----YCQLQPPVRGSREW 350
Query: 245 SPSQSCPEPEAPWWEAEEDEEEEN-------RCFTRPQAEI--SFCPHDAPSCLLGPQNR 295
+ +++ + + E ++ E + FT P E+ SF P S L+ NR
Sbjct: 351 AATETSSQQARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNR 410
Query: 296 PLEPQVLHTLRGLFLEHHPGSTALHLLLVDCQATGLLGVTRDQRGNMGVSSGLELLTLPH 355
PLE +L ++ L E + A H+ VDC +LGVT++ + MGV G+ELLTLPH
Sbjct: 411 PLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPH 470
Query: 356 GHHLRLELLERHQTLALAGALAVLGCSGPLEERAAALRGLVELALALRPGAAGDLPGLAA 415
G LRL+LLER T+++ A+ +LGC+G EERAA L ++LA LR G G++ AA
Sbjct: 471 GRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELR-GTMGNMFSFAA 529
Query: 416 VMGALLMPQVSRLEHTWRQLRRSHTEAALAFEQELKPLMRALDEGAGPCDPGEVALPHVA 475
VMGAL M Q+SRLE TW LR+ HTE A+ +E++LKP +++L+EG PHV
Sbjct: 530 VMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVL 589
Query: 476 PMVRLL-------EGEEVAGPLDESCERLLRTLHGARHMVRDAPKFRKVAAQRLRGFRPN 528
P++ LL EG E G + E +L L AR + + A +L+GF+
Sbjct: 590 PLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQAR 649
Query: 529 PELREALTTGFVRRLLWGSRGAGAPRAERFEKFQRVLGVLSQRLEP 574
PEL E +T F RLLWGS+GA + +A R+EKF +VL LS +LEP
Sbjct: 650 PELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEP 695
>gi|216547763 SH2 domain containing 3C isoform b [Homo sapiens]
Length = 703
Score = 315 bits (808), Expect = 6e-86
Identities = 219/646 (33%), Positives = 320/646 (49%), Gaps = 86/646 (13%)
Query: 9 DLAGQPWYHGLLSRQKAEALLQQNGDFLVRASGSRGGNPVISCRWRGSALHFEVFRVALR 68
DL WYHG + R+ +E L+Q+NGDFL+R S + G+ V++CRWR ALHF++ +V ++
Sbjct: 57 DLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVK 116
Query: 69 PRPGRPTALFQLEDEQFPSIPALVHSYMTGRRPLSQATGAVV------------------ 110
+ E E F +PALV ++ R+ +S+ +GA++
Sbjct: 117 AGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYG 176
Query: 111 --------SRPVTWQGPL-----RRSFS--------EDTLMDG-------PARIEPLRAR 142
+ PV+ GP RRS + + T DG P + +R+
Sbjct: 177 LGQGSSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSC 236
Query: 143 KWSNSQPADL----------------AHMGRSREDPAGMEASTMPISALPRTSSDPVLLK 186
S Q DL + + R PA A+ +P S + R SS+P L
Sbjct: 237 ALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCP 296
Query: 187 APAPL--GTVADSLRASDGQLQAKAPTKPPRTPSFELPDASERPPTYCELVPRVPSVQGT 244
AP G S KA P + S+ PD+ YC+L P V +
Sbjct: 297 GSAPKTHGESDKGPHTSPSHTLGKASPSPSLS-SYSDPDSGH----YCQLQPPVRGSREW 351
Query: 245 SPSQSCPEPEAPWWEAEEDEEEEN-------RCFTRPQAEI--SFCPHDAPSCLLGPQNR 295
+ +++ + + E ++ E + FT P E+ SF P S L+ NR
Sbjct: 352 AATETSSQQARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNR 411
Query: 296 PLEPQVLHTLRGLFLEHHPGSTALHLLLVDCQATGLLGVTRDQRGNMGVSSGLELLTLPH 355
PLE +L ++ L E + A H+ VDC +LGVT++ + MGV G+ELLTLPH
Sbjct: 412 PLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPH 471
Query: 356 GHHLRLELLERHQTLALAGALAVLGCSGPLEERAAALRGLVELALALRPGAAGDLPGLAA 415
G LRL+LLER T+++ A+ +LGC+G EERAA L ++LA LR G G++ AA
Sbjct: 472 GRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELR-GTMGNMFSFAA 530
Query: 416 VMGALLMPQVSRLEHTWRQLRRSHTEAALAFEQELKPLMRALDEGAGPCDPGEVALPHVA 475
VMGAL M Q+SRLE TW LR+ HTE A+ +E++LKP +++L+EG PHV
Sbjct: 531 VMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVL 590
Query: 476 PMVRLL-------EGEEVAGPLDESCERLLRTLHGARHMVRDAPKFRKVAAQRLRGFRPN 528
P++ LL EG E G + E +L L AR + + A +L+GF+
Sbjct: 591 PLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQAR 650
Query: 529 PELREALTTGFVRRLLWGSRGAGAPRAERFEKFQRVLGVLSQRLEP 574
PEL E +T F RLLWGS+GA + +A R+EKF +VL LS +LEP
Sbjct: 651 PELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEP 696
>gi|41281821 SH2 domain containing 3C isoform a [Homo sapiens]
Length = 860
Score = 315 bits (808), Expect = 6e-86
Identities = 219/646 (33%), Positives = 320/646 (49%), Gaps = 86/646 (13%)
Query: 9 DLAGQPWYHGLLSRQKAEALLQQNGDFLVRASGSRGGNPVISCRWRGSALHFEVFRVALR 68
DL WYHG + R+ +E L+Q+NGDFL+R S + G+ V++CRWR ALHF++ +V ++
Sbjct: 214 DLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVK 273
Query: 69 PRPGRPTALFQLEDEQFPSIPALVHSYMTGRRPLSQATGAVV------------------ 110
+ E E F +PALV ++ R+ +S+ +GA++
Sbjct: 274 AGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYG 333
Query: 111 --------SRPVTWQGPL-----RRSFS--------EDTLMDG-------PARIEPLRAR 142
+ PV+ GP RRS + + T DG P + +R+
Sbjct: 334 LGQGSSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSC 393
Query: 143 KWSNSQPADL----------------AHMGRSREDPAGMEASTMPISALPRTSSDPVLLK 186
S Q DL + + R PA A+ +P S + R SS+P L
Sbjct: 394 ALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCP 453
Query: 187 APAPL--GTVADSLRASDGQLQAKAPTKPPRTPSFELPDASERPPTYCELVPRVPSVQGT 244
AP G S KA P + S+ PD+ YC+L P V +
Sbjct: 454 GSAPKTHGESDKGPHTSPSHTLGKASPSPSLS-SYSDPDSGH----YCQLQPPVRGSREW 508
Query: 245 SPSQSCPEPEAPWWEAEEDEEEEN-------RCFTRPQAEI--SFCPHDAPSCLLGPQNR 295
+ +++ + + E ++ E + FT P E+ SF P S L+ NR
Sbjct: 509 AATETSSQQARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNR 568
Query: 296 PLEPQVLHTLRGLFLEHHPGSTALHLLLVDCQATGLLGVTRDQRGNMGVSSGLELLTLPH 355
PLE +L ++ L E + A H+ VDC +LGVT++ + MGV G+ELLTLPH
Sbjct: 569 PLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPH 628
Query: 356 GHHLRLELLERHQTLALAGALAVLGCSGPLEERAAALRGLVELALALRPGAAGDLPGLAA 415
G LRL+LLER T+++ A+ +LGC+G EERAA L ++LA LR G G++ AA
Sbjct: 629 GRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELR-GTMGNMFSFAA 687
Query: 416 VMGALLMPQVSRLEHTWRQLRRSHTEAALAFEQELKPLMRALDEGAGPCDPGEVALPHVA 475
VMGAL M Q+SRLE TW LR+ HTE A+ +E++LKP +++L+EG PHV
Sbjct: 688 VMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVL 747
Query: 476 PMVRLL-------EGEEVAGPLDESCERLLRTLHGARHMVRDAPKFRKVAAQRLRGFRPN 528
P++ LL EG E G + E +L L AR + + A +L+GF+
Sbjct: 748 PLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQAR 807
Query: 529 PELREALTTGFVRRLLWGSRGAGAPRAERFEKFQRVLGVLSQRLEP 574
PEL E +T F RLLWGS+GA + +A R+EKF +VL LS +LEP
Sbjct: 808 PELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEP 853
>gi|216547779 SH2 domain containing 3C isoform c [Homo sapiens]
Length = 506
Score = 255 bits (651), Expect = 9e-68
Identities = 169/455 (37%), Positives = 239/455 (52%), Gaps = 25/455 (5%)
Query: 138 PLRARKWSNSQPADLAHMGRSREDPAGMEASTMPISALPRTSSDPVLLKAPAPL--GTVA 195
P+ S S PA + + R PA A+ +P S + R SS+P L AP G
Sbjct: 52 PMSPISESPSSPA-YSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGESD 110
Query: 196 DSLRASDGQLQAKAPTKPPRTPSFELPDASERPPTYCELVPRVPSVQGTSPSQSCPEPEA 255
S KA P + S+ PD+ YC+L P V + + +++ +
Sbjct: 111 KGPHTSPSHTLGKASPSPSLS-SYSDPDSGH----YCQLQPPVRGSREWAATETSSQQAR 165
Query: 256 PWWEAEEDEEEEN-------RCFTRPQAEI--SFCPHDAPSCLLGPQNRPLEPQVLHTLR 306
+ E ++ E + FT P E+ SF P S L+ NRPLE +L ++
Sbjct: 166 SYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVK 225
Query: 307 GLFLEHHPGSTALHLLLVDCQATGLLGVTRDQRGNMGVSSGLELLTLPHGHHLRLELLER 366
L E + A H+ VDC +LGVT++ + MGV G+ELLTLPHG LRL+LLER
Sbjct: 226 ELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLER 285
Query: 367 HQTLALAGALAVLGCSGPLEERAAALRGLVELALALRPGAAGDLPGLAAVMGALLMPQVS 426
T+++ A+ +LGC+G EERAA L ++LA LR G G++ AAVMGAL M Q+S
Sbjct: 286 FHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELR-GTMGNMFSFAAVMGALDMAQIS 344
Query: 427 RLEHTWRQLRRSHTEAALAFEQELKPLMRALDEGAGPCDPGEVALPHVAPMVRLL----- 481
RLE TW LR+ HTE A+ +E++LKP +++L+EG PHV P++ LL
Sbjct: 345 RLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSA 404
Query: 482 --EGEEVAGPLDESCERLLRTLHGARHMVRDAPKFRKVAAQRLRGFRPNPELREALTTGF 539
EG E G + E +L L AR + + A +L+GF+ PEL E +T F
Sbjct: 405 PPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEF 464
Query: 540 VRRLLWGSRGAGAPRAERFEKFQRVLGVLSQRLEP 574
RLLWGS+GA + +A R+EKF +VL LS +LEP
Sbjct: 465 QMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEP 499
>gi|216547769 SH2 domain containing 3C isoform c [Homo sapiens]
Length = 506
Score = 255 bits (651), Expect = 9e-68
Identities = 169/455 (37%), Positives = 239/455 (52%), Gaps = 25/455 (5%)
Query: 138 PLRARKWSNSQPADLAHMGRSREDPAGMEASTMPISALPRTSSDPVLLKAPAPL--GTVA 195
P+ S S PA + + R PA A+ +P S + R SS+P L AP G
Sbjct: 52 PMSPISESPSSPA-YSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGESD 110
Query: 196 DSLRASDGQLQAKAPTKPPRTPSFELPDASERPPTYCELVPRVPSVQGTSPSQSCPEPEA 255
S KA P + S+ PD+ YC+L P V + + +++ +
Sbjct: 111 KGPHTSPSHTLGKASPSPSLS-SYSDPDSGH----YCQLQPPVRGSREWAATETSSQQAR 165
Query: 256 PWWEAEEDEEEEN-------RCFTRPQAEI--SFCPHDAPSCLLGPQNRPLEPQVLHTLR 306
+ E ++ E + FT P E+ SF P S L+ NRPLE +L ++
Sbjct: 166 SYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVK 225
Query: 307 GLFLEHHPGSTALHLLLVDCQATGLLGVTRDQRGNMGVSSGLELLTLPHGHHLRLELLER 366
L E + A H+ VDC +LGVT++ + MGV G+ELLTLPHG LRL+LLER
Sbjct: 226 ELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLER 285
Query: 367 HQTLALAGALAVLGCSGPLEERAAALRGLVELALALRPGAAGDLPGLAAVMGALLMPQVS 426
T+++ A+ +LGC+G EERAA L ++LA LR G G++ AAVMGAL M Q+S
Sbjct: 286 FHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELR-GTMGNMFSFAAVMGALDMAQIS 344
Query: 427 RLEHTWRQLRRSHTEAALAFEQELKPLMRALDEGAGPCDPGEVALPHVAPMVRLL----- 481
RLE TW LR+ HTE A+ +E++LKP +++L+EG PHV P++ LL
Sbjct: 345 RLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSA 404
Query: 482 --EGEEVAGPLDESCERLLRTLHGARHMVRDAPKFRKVAAQRLRGFRPNPELREALTTGF 539
EG E G + E +L L AR + + A +L+GF+ PEL E +T F
Sbjct: 405 PPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEF 464
Query: 540 VRRLLWGSRGAGAPRAERFEKFQRVLGVLSQRLEP 574
RLLWGS+GA + +A R+EKF +VL LS +LEP
Sbjct: 465 QMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEP 499
>gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens]
Length = 764
Score = 65.1 bits (157), Expect = 2e-10
Identities = 39/112 (34%), Positives = 60/112 (53%), Gaps = 10/112 (8%)
Query: 3 VPQDGEDLAGQPWYHGLLSRQKAEALLQQNGDFLVRASGSRGGNPVISCRWRGSALHFEV 62
+P+ + L Q WYHG + R + LL +GDFLVR S + V+S W G HF +
Sbjct: 390 IPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQGK-QEYVLSVLWDGLPRHFII 448
Query: 63 FRVALRPRPGRPTALFQLEDEQFPSIPALVHSYMTGRRPLSQATGAVVSRPV 114
+ L++LE E FPSIP L+ ++ ++PL++ +G V+ R V
Sbjct: 449 QSL---------DNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAV 491
>gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens]
Length = 822
Score = 65.1 bits (157), Expect = 2e-10
Identities = 39/112 (34%), Positives = 60/112 (53%), Gaps = 10/112 (8%)
Query: 3 VPQDGEDLAGQPWYHGLLSRQKAEALLQQNGDFLVRASGSRGGNPVISCRWRGSALHFEV 62
+P+ + L Q WYHG + R + LL +GDFLVR S + V+S W G HF +
Sbjct: 448 IPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQGK-QEYVLSVLWDGLPRHFII 506
Query: 63 FRVALRPRPGRPTALFQLEDEQFPSIPALVHSYMTGRRPLSQATGAVVSRPV 114
+ L++LE E FPSIP L+ ++ ++PL++ +G V+ R V
Sbjct: 507 QSL---------DNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAV 549
>gi|194239668 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 4 [Homo sapiens]
Length = 473
Score = 63.9 bits (154), Expect = 4e-10
Identities = 36/98 (36%), Positives = 52/98 (53%), Gaps = 9/98 (9%)
Query: 8 EDLAGQPWYHGLLSRQKAEALLQQNGDFLVRASGSRGGNPVISCRWRGSALHFEVFRVAL 67
E L G+PW+HG LSR++AEALLQ NGDFLVR S + G V++ G H +
Sbjct: 371 EQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLV---- 426
Query: 68 RPRPGRPTALFQLEDEQFPSIPALVHSYMTGRRPLSQA 105
P + + +D +F S+ L+ +M P+ A
Sbjct: 427 -----DPEGVVRTKDHRFESVSHLISYHMDNHLPIISA 459
>gi|194239664 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 3 [Homo sapiens]
Length = 584
Score = 63.9 bits (154), Expect = 4e-10
Identities = 36/98 (36%), Positives = 52/98 (53%), Gaps = 9/98 (9%)
Query: 8 EDLAGQPWYHGLLSRQKAEALLQQNGDFLVRASGSRGGNPVISCRWRGSALHFEVFRVAL 67
E L G+PW+HG LSR++AEALLQ NGDFLVR S + G V++ G H +
Sbjct: 482 EQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLV---- 537
Query: 68 RPRPGRPTALFQLEDEQFPSIPALVHSYMTGRRPLSQA 105
P + + +D +F S+ L+ +M P+ A
Sbjct: 538 -----DPEGVVRTKDHRFESVSHLISYHMDNHLPIISA 570
>gi|194239662 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 1 [Homo sapiens]
Length = 583
Score = 63.9 bits (154), Expect = 4e-10
Identities = 36/98 (36%), Positives = 52/98 (53%), Gaps = 9/98 (9%)
Query: 8 EDLAGQPWYHGLLSRQKAEALLQQNGDFLVRASGSRGGNPVISCRWRGSALHFEVFRVAL 67
E L G+PW+HG LSR++AEALLQ NGDFLVR S + G V++ G H +
Sbjct: 481 EQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLV---- 536
Query: 68 RPRPGRPTALFQLEDEQFPSIPALVHSYMTGRRPLSQA 105
P + + +D +F S+ L+ +M P+ A
Sbjct: 537 -----DPEGVVRTKDHRFESVSHLISYHMDNHLPIISA 569
>gi|32261324 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 2 [Homo sapiens]
Length = 474
Score = 63.9 bits (154), Expect = 4e-10
Identities = 36/98 (36%), Positives = 52/98 (53%), Gaps = 9/98 (9%)
Query: 8 EDLAGQPWYHGLLSRQKAEALLQQNGDFLVRASGSRGGNPVISCRWRGSALHFEVFRVAL 67
E L G+PW+HG LSR++AEALLQ NGDFLVR S + G V++ G H +
Sbjct: 372 EQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLV---- 427
Query: 68 RPRPGRPTALFQLEDEQFPSIPALVHSYMTGRRPLSQA 105
P + + +D +F S+ L+ +M P+ A
Sbjct: 428 -----DPEGVVRTKDHRFESVSHLISYHMDNHLPIISA 460
>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
Length = 822
Score = 60.8 bits (146), Expect = 3e-09
Identities = 34/105 (32%), Positives = 56/105 (53%), Gaps = 9/105 (8%)
Query: 10 LAGQPWYHGLLSRQKAEALLQQNGDFLVRASGSRGGNPVISCRWRGSALHFEVFRVALRP 69
LA Q WYHG + R +A+ LL++ GDFLVR S + G V+S G HF + V
Sbjct: 455 LAEQDWYHGAIPRIEAQELLKKQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYV---- 510
Query: 70 RPGRPTALFQLEDEQFPSIPALVHSYMTGRRPLSQATGAVVSRPV 114
+++ E F +IP L+ + T ++ +++ +G V+ P+
Sbjct: 511 -----DNMYRFEGTGFSNIPQLIDHHYTTKQVITKKSGVVLLNPI 550
>gi|224586793 src homology 2 domain-containing transforming protein
C3 [Homo sapiens]
Length = 594
Score = 54.7 bits (130), Expect = 2e-07
Identities = 31/98 (31%), Positives = 51/98 (52%), Gaps = 9/98 (9%)
Query: 8 EDLAGQPWYHGLLSRQKAEALLQQNGDFLVRASGSRGGNPVISCRWRGSALHFEVFRVAL 67
E+L + WY G +SR++AE LL+++GDFLVR S + G+ V++ G A H +
Sbjct: 492 EELQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLV---- 547
Query: 68 RPRPGRPTALFQLEDEQFPSIPALVHSYMTGRRPLSQA 105
P + +D F SI L++ ++ P+ A
Sbjct: 548 -----DPEGTIRTKDRVFDSISHLINHHLESSLPIVSA 580
>gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo
sapiens]
Length = 475
Score = 54.3 bits (129), Expect = 3e-07
Identities = 34/112 (30%), Positives = 54/112 (48%), Gaps = 9/112 (8%)
Query: 8 EDLAGQPWYHGLLSRQKAEALLQQNGDFLVRASGSRGGNPVISCRWRGSALHFEVFRVAL 67
E L +PWYHG +SR+ AE +L+ +GDFLVR S + G V++ G H +
Sbjct: 373 EQLRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLV---- 428
Query: 68 RPRPGRPTALFQLEDEQFPSIPALVHSYMTGRRPLSQATGAVVSRPVTWQGP 119
P + + +D F SI L+ ++ +P+ A + R V + P
Sbjct: 429 -----DPEGVVRTKDVLFESISHLIDHHLQNGQPIVAAESELHLRGVVSREP 475
>gi|169790811 SHC (Src homology 2 domain containing) transforming
protein 2 [Homo sapiens]
Length = 582
Score = 54.3 bits (129), Expect = 3e-07
Identities = 34/112 (30%), Positives = 54/112 (48%), Gaps = 9/112 (8%)
Query: 8 EDLAGQPWYHGLLSRQKAEALLQQNGDFLVRASGSRGGNPVISCRWRGSALHFEVFRVAL 67
E L +PWYHG +SR+ AE +L+ +GDFLVR S + G V++ G H +
Sbjct: 480 EQLRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLV---- 535
Query: 68 RPRPGRPTALFQLEDEQFPSIPALVHSYMTGRRPLSQATGAVVSRPVTWQGP 119
P + + +D F SI L+ ++ +P+ A + R V + P
Sbjct: 536 -----DPEGVVRTKDVLFESISHLIDHHLQNGQPIVAAESELHLRGVVSREP 582
Score = 30.0 bits (66), Expect = 6.0
Identities = 14/39 (35%), Positives = 20/39 (51%), Gaps = 6/39 (15%)
Query: 208 KAPTKPPRTPSFELPDASERPPTYCELVPRVPSVQGTSP 246
+AP PP P E P T+C L+PR+P + +P
Sbjct: 8 RAPPAPPAPPE------PEAPTTFCALLPRMPQWKFAAP 40
>gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a
[Homo sapiens]
Length = 304
Score = 49.7 bits (117), Expect = 7e-06
Identities = 33/92 (35%), Positives = 48/92 (52%), Gaps = 11/92 (11%)
Query: 15 WYHGLLSRQKAEALL--QQNGDFLVRASGSRGGNPVISCRWRGSALHFEVFRVALR---- 68
WY G LSRQ+A ALL Q++G FLVR S + G+ V+S H+ + R
Sbjct: 13 WYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPVP 72
Query: 69 -----PRPGRPTALFQLEDEQFPSIPALVHSY 95
P PG + ++ D++F S+PAL+ Y
Sbjct: 73 PSPAQPPPGVSPSRLRIGDQEFDSLPALLEFY 104
>gi|41327710 v-crk sarcoma virus CT10 oncogene homolog isoform b
[Homo sapiens]
Length = 204
Score = 49.7 bits (117), Expect = 7e-06
Identities = 33/92 (35%), Positives = 48/92 (52%), Gaps = 11/92 (11%)
Query: 15 WYHGLLSRQKAEALL--QQNGDFLVRASGSRGGNPVISCRWRGSALHFEVFRVALR---- 68
WY G LSRQ+A ALL Q++G FLVR S + G+ V+S H+ + R
Sbjct: 13 WYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPVP 72
Query: 69 -----PRPGRPTALFQLEDEQFPSIPALVHSY 95
P PG + ++ D++F S+PAL+ Y
Sbjct: 73 PSPAQPPPGVSPSRLRIGDQEFDSLPALLEFY 104
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 48.9 bits (115), Expect = 1e-05
Identities = 30/85 (35%), Positives = 40/85 (47%), Gaps = 9/85 (10%)
Query: 15 WYHGLLSRQKAEALLQQ--NGDFLVRASGSRGGNPVISCRWRGSALHFEVFRVALRPRPG 72
WYHG +SR AE LL NG FLVR S S G IS R+ G H+ +
Sbjct: 127 WYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRI-------NTA 179
Query: 73 RPTALFQLEDEQFPSIPALVHSYMT 97
L+ + +F ++ LVH + T
Sbjct: 180 SDGKLYVSSESRFNTLAELVHHHST 204
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 48.9 bits (115), Expect = 1e-05
Identities = 30/85 (35%), Positives = 40/85 (47%), Gaps = 9/85 (10%)
Query: 15 WYHGLLSRQKAEALLQQ--NGDFLVRASGSRGGNPVISCRWRGSALHFEVFRVALRPRPG 72
WYHG +SR AE LL NG FLVR S S G IS R+ G H+ +
Sbjct: 146 WYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRI-------NTA 198
Query: 73 RPTALFQLEDEQFPSIPALVHSYMT 97
L+ + +F ++ LVH + T
Sbjct: 199 SDGKLYVSSESRFNTLAELVHHHST 223
>gi|222446609 rai-like protein [Homo sapiens]
Length = 630
Score = 48.5 bits (114), Expect = 2e-05
Identities = 34/113 (30%), Positives = 54/113 (47%), Gaps = 10/113 (8%)
Query: 3 VPQDGEDLAGQPWYHGLLSRQKAEALLQQNGDFLVRASGSRGGNPVISCRWRGSALHFEV 62
+P + L + YHG LSR+ AE+LL ++GDFLVR S + G V+S G A H +
Sbjct: 514 LPHIKQQLWSEECYHGKLSRKAAESLLVKDGDFLVRESATSPGQYVLSGLQGGQAKHLLL 573
Query: 63 FRVALRPRPGRPTALFQLEDEQFPSIPALVHSYMTGRRP-LSQATGAVVSRPV 114
P + +D F ++ L+ +M P +S + + +PV
Sbjct: 574 V---------DPEGKVRTKDHVFDNVGHLIRYHMDNSLPIISSGSEVSLKQPV 617
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 48.5 bits (114), Expect = 2e-05
Identities = 30/85 (35%), Positives = 41/85 (48%), Gaps = 9/85 (10%)
Query: 15 WYHGLLSRQKAEALLQQ--NGDFLVRASGSRGGNPVISCRWRGSALHFEVFRVALRPRPG 72
WYHG +SR AE LL NG FLVR S S G IS R+ G H+ + A
Sbjct: 158 WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTA------ 211
Query: 73 RPTALFQLEDEQFPSIPALVHSYMT 97
++ + +F ++ LVH + T
Sbjct: 212 -DGKVYVTAESRFSTLAELVHHHST 235
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 48.5 bits (114), Expect = 2e-05
Identities = 30/85 (35%), Positives = 41/85 (48%), Gaps = 9/85 (10%)
Query: 15 WYHGLLSRQKAEALLQQ--NGDFLVRASGSRGGNPVISCRWRGSALHFEVFRVALRPRPG 72
WYHG +SR AE LL NG FLVR S S G IS R+ G H+ + A
Sbjct: 173 WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTA------ 226
Query: 73 RPTALFQLEDEQFPSIPALVHSYMT 97
++ + +F ++ LVH + T
Sbjct: 227 -DGKVYVTAESRFSTLAELVHHHST 250
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 48.5 bits (114), Expect = 2e-05
Identities = 30/85 (35%), Positives = 41/85 (48%), Gaps = 9/85 (10%)
Query: 15 WYHGLLSRQKAEALLQQ--NGDFLVRASGSRGGNPVISCRWRGSALHFEVFRVALRPRPG 72
WYHG +SR AE LL NG FLVR S S G IS R+ G H+ + A
Sbjct: 152 WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTA------ 205
Query: 73 RPTALFQLEDEQFPSIPALVHSYMT 97
++ + +F ++ LVH + T
Sbjct: 206 -DGKVYVTAESRFSTLAELVHHHST 229
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 48.5 bits (114), Expect = 2e-05
Identities = 30/85 (35%), Positives = 41/85 (48%), Gaps = 9/85 (10%)
Query: 15 WYHGLLSRQKAEALLQQ--NGDFLVRASGSRGGNPVISCRWRGSALHFEVFRVALRPRPG 72
WYHG +SR AE LL NG FLVR S S G IS R+ G H+ + A
Sbjct: 158 WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTA------ 211
Query: 73 RPTALFQLEDEQFPSIPALVHSYMT 97
++ + +F ++ LVH + T
Sbjct: 212 -DGKVYVTAESRFSTLAELVHHHST 235
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 48.5 bits (114), Expect = 2e-05
Identities = 30/85 (35%), Positives = 41/85 (48%), Gaps = 9/85 (10%)
Query: 15 WYHGLLSRQKAEALLQQ--NGDFLVRASGSRGGNPVISCRWRGSALHFEVFRVALRPRPG 72
WYHG +SR AE LL NG FLVR S S G IS R+ G H+ + A
Sbjct: 137 WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTA------ 190
Query: 73 RPTALFQLEDEQFPSIPALVHSYMT 97
++ + +F ++ LVH + T
Sbjct: 191 -DGKVYVTAESRFSTLAELVHHHST 214
>gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens]
Length = 330
Score = 48.1 bits (113), Expect = 2e-05
Identities = 36/97 (37%), Positives = 51/97 (52%), Gaps = 10/97 (10%)
Query: 3 VPQDGEDLAGQPWYHGLLSRQKAEALL--QQNGDFLVRASGSRGGNPVISCRWRGSALHF 60
VP++ D+ W+H LSR +AE LL ++ G F++RAS S G+ IS R HF
Sbjct: 46 VPKNFIDIQFPKWFHEGLSRHQAENLLMGKEVGFFIIRASQSSPGDFSISVRHEDDVQHF 105
Query: 61 EVFRVALRPRPGRPTALFQLEDEQFPSIPALVHSYMT 97
+V +R G + L E+FPS+ LV Y T
Sbjct: 106 KV----MRDNKGN----YFLWTEKFPSLNKLVDYYRT 134
>gi|5729856 GRB2-related adaptor protein [Homo sapiens]
Length = 217
Score = 47.8 bits (112), Expect = 3e-05
Identities = 42/154 (27%), Positives = 68/154 (44%), Gaps = 26/154 (16%)
Query: 3 VPQDGEDLAGQPWYHGLLSRQKAEALLQQN---GDFLVRASGSRGGNPVISCRWRGSALH 59
+P++ + PWY G +SRQ AE +L + G FL+R S S G +S + H
Sbjct: 48 IPKNYIRVKPHPWYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQH 107
Query: 60 FEVFRVALRPRPGRPTALFQLEDEQFPSIPALVHSYMT------------GRRPLSQATG 107
F+V R A + + L +E+F S+ LV Y T PL ++ G
Sbjct: 108 FKVLREA--------SGKYFLWEEKFNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSPG 159
Query: 108 AVVSR---PVTWQGPLRRSFSEDTLMDGPARIEP 138
A ++ + Q P + SF +++ R +P
Sbjct: 160 ACFAQAQFDFSAQDPSQLSFRRGDIIEVLERPDP 193
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,208,614
Number of Sequences: 37866
Number of extensions: 1426999
Number of successful extensions: 5878
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 51
Number of HSP's successfully gapped in prelim test: 232
Number of HSP's that attempted gapping in prelim test: 5480
Number of HSP's gapped (non-prelim): 601
length of query: 576
length of database: 18,247,518
effective HSP length: 108
effective length of query: 468
effective length of database: 14,157,990
effective search space: 6625939320
effective search space used: 6625939320
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.