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Search of human proteins with 208609951
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|208609951 neurexin 1 isoform alpha2 precursor [Homo sapiens]
(1547 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|208609951 neurexin 1 isoform alpha2 precursor [Homo sapiens] 3145 0.0
gi|14149613 neurexin 1 isoform alpha1 precursor [Homo sapiens] 2959 0.0
gi|14211536 neurexin 2 isoform alpha-1 precursor [Homo sapiens] 1966 0.0
gi|21166380 neurexin 2 isoform alpha-2 precursor [Homo sapiens] 1861 0.0
gi|21070969 neurexin 3 isoform 1 precursor [Homo sapiens] 1675 0.0
gi|21070967 neurexin 1 isoform beta precursor [Homo sapiens] 688 0.0
gi|157427673 neurexin 3 isoform 3 precursor [Homo sapiens] 518 e-146
gi|41350305 neurexin 3 isoform 2 precursor [Homo sapiens] 473 e-133
gi|21166382 neurexin 2 isoform beta precursor [Homo sapiens] 439 e-123
gi|47519929 cell recognition molecule CASPR3 [Homo sapiens] 219 2e-56
gi|239743754 PREDICTED: hypothetical protein LOC389722 isoform 1... 214 5e-55
gi|239743756 PREDICTED: hypothetical protein LOC389722 isoform 2... 164 8e-40
gi|7662350 cell recognition molecule Caspr2 precursor [Homo sapi... 159 3e-38
gi|54873613 agrin [Homo sapiens] 134 9e-31
gi|116284404 cell recognition protein CASPR4 isoform 1 [Homo sap... 132 3e-30
gi|4505463 contactin associated protein 1 precursor [Homo sapiens] 131 6e-30
gi|18640734 contactin associated protein-like 5 [Homo sapiens] 127 1e-28
gi|33469931 EGF-like, fibronectin type III and laminin G domains... 126 2e-28
gi|33469929 EGF-like, fibronectin type III and laminin G domains... 126 2e-28
gi|38788416 laminin, alpha 1 precursor [Homo sapiens] 125 4e-28
gi|148664242 cell recognition protein CASPR4 isoform 2 [Homo sap... 114 6e-25
gi|239743797 PREDICTED: similar to cell recognition molecule CAS... 114 7e-25
gi|119466532 laminin alpha 2 subunit isoform b precursor [Homo s... 105 3e-22
gi|28559088 laminin alpha 2 subunit isoform a precursor [Homo sa... 104 8e-22
gi|33469935 EGF-like, fibronectin type III and laminin G domains... 98 7e-20
gi|41327708 crumbs homolog 1 precursor [Homo sapiens] 95 5e-19
gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo... 91 9e-18
gi|157419126 laminin, alpha 4 isoform 2 precursor [Homo sapiens] 87 1e-16
gi|157419124 laminin, alpha 4 isoform 1 precursor [Homo sapiens] 87 1e-16
gi|157419122 laminin, alpha 4 isoform 2 precursor [Homo sapiens] 87 1e-16
>gi|208609951 neurexin 1 isoform alpha2 precursor [Homo sapiens]
Length = 1547
Score = 3145 bits (8155), Expect = 0.0
Identities = 1547/1547 (100%), Positives = 1547/1547 (100%)
Query: 1 MGTALLQRGGCFLLCLSLLLLGCWAELGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKT 60
MGTALLQRGGCFLLCLSLLLLGCWAELGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKT
Sbjct: 1 MGTALLQRGGCFLLCLSLLLLGCWAELGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKT 60
Query: 61 RSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIR 120
RSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIR
Sbjct: 61 RSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIR 120
Query: 121 RQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPF 180
RQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPF
Sbjct: 121 RQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPF 180
Query: 181 KGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQ 240
KGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQ
Sbjct: 181 KGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQ 240
Query: 241 AVCDCSRTGFRGKDCSQEIKFGLQCVLPVLLHDNDQGKYCCINTAKPLTEKDNNVEGLAH 300
AVCDCSRTGFRGKDCSQEIKFGLQCVLPVLLHDNDQGKYCCINTAKPLTEKDNNVEGLAH
Sbjct: 241 AVCDCSRTGFRGKDCSQEIKFGLQCVLPVLLHDNDQGKYCCINTAKPLTEKDNNVEGLAH 300
Query: 301 LMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGKS 360
LMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGKS
Sbjct: 301 LMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGKS 360
Query: 361 ADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMV 420
ADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMV
Sbjct: 361 ADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMV 420
Query: 421 NKLHCSVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKE 480
NKLHCSVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKE
Sbjct: 421 NKLHCSVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKE 480
Query: 481 VVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPESFISLPKWNAKK 540
VVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPESFISLPKWNAKK
Sbjct: 481 VVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPESFISLPKWNAKK 540
Query: 541 TGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGT 600
TGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGT
Sbjct: 541 TGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGT 600
Query: 601 IKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPE 660
IKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPE
Sbjct: 601 IKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPE 660
Query: 661 NKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPC 720
NKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPC
Sbjct: 661 NKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPC 720
Query: 721 LSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAE 780
LSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAE
Sbjct: 721 LSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAE 780
Query: 781 DVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLFA 840
DVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLFA
Sbjct: 781 DVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLFA 840
Query: 841 GYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETGIITERRYLSS 900
GYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETGIITERRYLSS
Sbjct: 841 GYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETGIITERRYLSS 900
Query: 901 VPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIADPVTFKTKSSYVALAT 960
VPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIADPVTFKTKSSYVALAT
Sbjct: 901 VPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIADPVTFKTKSSYVALAT 960
Query: 961 LQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSN 1020
LQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSN
Sbjct: 961 LQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSN 1020
Query: 1021 KPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLP 1080
KPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLP
Sbjct: 1021 KPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLP 1080
Query: 1081 KLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQ 1140
KLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQ
Sbjct: 1081 KLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQ 1140
Query: 1141 QWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQ 1200
QWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQ
Sbjct: 1141 QWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQ 1200
Query: 1201 KEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRS 1260
KEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRS
Sbjct: 1201 KEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRS 1260
Query: 1261 GGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQA 1320
GGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQA
Sbjct: 1261 GGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQA 1320
Query: 1321 TIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTA 1380
TIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTA
Sbjct: 1321 TIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTA 1380
Query: 1381 TAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDDILVASAECPSDDEDIDPCEP 1440
TAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDDILVASAECPSDDEDIDPCEP
Sbjct: 1381 TAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDDILVASAECPSDDEDIDPCEP 1440
Query: 1441 SSGGLANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDE 1500
SSGGLANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDE
Sbjct: 1441 SSGGLANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDE 1500
Query: 1501 GSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV 1547
GSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV
Sbjct: 1501 GSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV 1547
>gi|14149613 neurexin 1 isoform alpha1 precursor [Homo sapiens]
Length = 1477
Score = 2959 bits (7671), Expect = 0.0
Identities = 1477/1547 (95%), Positives = 1477/1547 (95%), Gaps = 70/1547 (4%)
Query: 1 MGTALLQRGGCFLLCLSLLLLGCWAELGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKT 60
MGTALLQRGGCFLLCLSLLLLGCWAELGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKT
Sbjct: 1 MGTALLQRGGCFLLCLSLLLLGCWAELGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKT 60
Query: 61 RSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIR 120
RSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIR
Sbjct: 61 RSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIR 120
Query: 121 RQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPF 180
RQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPF
Sbjct: 121 RQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPF 180
Query: 181 KGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQ 240
KGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQ
Sbjct: 181 KGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQ 240
Query: 241 AVCDCSRTGFRGKDCSQEIKFGLQCVLPVLLHDNDQGKYCCINTAKPLTEKDNNVEGLAH 300
AVCDCSRTGFRGKDCSQE DNNVEGLAH
Sbjct: 241 AVCDCSRTGFRGKDCSQE---------------------------------DNNVEGLAH 267
Query: 301 LMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGKS 360
LMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGKS
Sbjct: 268 LMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGKS 327
Query: 361 ADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMV 420
ADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMV
Sbjct: 328 ADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMV 387
Query: 421 NKLHCSVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKE 480
TISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKE
Sbjct: 388 -------TISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKE 440
Query: 481 VVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPESFISLPKWNAKK 540
VVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPESFISLPKWNAKK
Sbjct: 441 VVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPESFISLPKWNAKK 500
Query: 541 TGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGT 600
TGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGT
Sbjct: 501 TGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGT 560
Query: 601 IKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPE 660
IKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPE
Sbjct: 561 IKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPE 620
Query: 661 NKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPC 720
NKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPC
Sbjct: 621 NKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPC 680
Query: 721 LSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAE 780
LSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAE
Sbjct: 681 LSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAE 740
Query: 781 DVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLFA 840
DVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLFA
Sbjct: 741 DVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLFA 800
Query: 841 GYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETGIITERRYLSS 900
GYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETGIITERRYLSS
Sbjct: 801 GYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETGIITERRYLSS 860
Query: 901 VPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIADPVTFKTKSSYVALAT 960
VPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIADPVTFKTKSSYVALAT
Sbjct: 861 VPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIADPVTFKTKSSYVALAT 920
Query: 961 LQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSN 1020
LQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSN
Sbjct: 921 LQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSN 980
Query: 1021 KPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLP 1080
KPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLP
Sbjct: 981 KPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLP 1040
Query: 1081 KLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQ 1140
KLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQ
Sbjct: 1041 KLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQ 1100
Query: 1141 QWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQ 1200
QWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQ
Sbjct: 1101 QWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQ 1160
Query: 1201 KEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRS 1260
KEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRS
Sbjct: 1161 KEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRS 1220
Query: 1261 GGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQA 1320
GGNATLQVDSWPVIERYPA GRQLTIFNSQA
Sbjct: 1221 GGNATLQVDSWPVIERYPA------------------------------GRQLTIFNSQA 1250
Query: 1321 TIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTA 1380
TIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTA
Sbjct: 1251 TIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTA 1310
Query: 1381 TAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDDILVASAECPSDDEDIDPCEP 1440
TAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDDILVASAECPSDDEDIDPCEP
Sbjct: 1311 TAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDDILVASAECPSDDEDIDPCEP 1370
Query: 1441 SSGGLANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDE 1500
SSGGLANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDE
Sbjct: 1371 SSGGLANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDE 1430
Query: 1501 GSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV 1547
GSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV
Sbjct: 1431 GSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV 1477
>gi|14211536 neurexin 2 isoform alpha-1 precursor [Homo sapiens]
Length = 1712
Score = 1966 bits (5093), Expect = 0.0
Identities = 975/1442 (67%), Positives = 1163/1442 (80%), Gaps = 49/1442 (3%)
Query: 16 LSLLLLGCWAELGSGLEFPGAEGQWTRFPKW-NACCESEMSFQLKTRSARGLVLYFDDEG 74
L LLLL A GLEF G GQW R+ +W A E+SF L+T + R L+LY DD G
Sbjct: 14 LLLLLLLALAARADGLEFGGGPGQWARYARWAGAASSGELSFSLRTNATRALLLYLDDGG 73
Query: 75 FCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVE 134
CDFLEL+L GRL+L F++ CAEPATL DTPV D WH V + R R T L +D E
Sbjct: 74 DCDFLELLLV-DGRLRLRFTLSCAEPATLQLDTPVADDRWHMVLLTRDARRTALAVDG-E 131
Query: 135 AKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQV 194
A+ EV+SKRR+M V S LFVGG+PP++R +AL TL++V+ PF+G + ++
Sbjct: 132 ARAAEVRSKRREMQVASDLFVGGIPPDVRLSAL--TLSTVKYEPPFRGLLANL------- 182
Query: 195 LPVDSGEVKLDDEPPNSGG-----GSPCEAGEEGEGGVCLNGGVCSVVDDQAV-CDCSRT 248
KL + PP G G+ + C NGG+C+V+ V CDCS T
Sbjct: 183 --------KLGERPPALLGSQGLRGATADPLCAPARNPCANGGLCTVLAPGEVGCDCSHT 234
Query: 249 GFRGKDCSQEIKFGLQCVLPVLLHDNDQGKYCCINT--AKPLTEKDNNVEGLAHLMMGDQ 306
GF GK CS+E H + + +N+ L + G A GD
Sbjct: 235 GFGGKFCSEEE------------HPMEGPAHLTLNSEVGSLLFSEGGAGRGGA----GDV 278
Query: 307 GK-SKGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGKSADYVN 365
+ +KGKEE++ATFKG+E+FCYDLS NPIQSS+DEITL+F+TLQRNGLMLHTGKSADYVN
Sbjct: 279 HQPTKGKEEFVATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHTGKSADYVN 338
Query: 366 LALKNGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVNKLHC 425
L+LK+GAV LVINLGSGAFEALVEPVNGKFNDNAWHDV+VTRNLRQH+GIGHAMVNKLH
Sbjct: 339 LSLKSGAVWLVINLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNKLHY 398
Query: 426 SVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKN 485
VTISVDGILTTTGYTQEDYTMLGSDDFFY+GGSP+TADLPGSPVSNNFMGCLK+VVYKN
Sbjct: 399 LVTISVDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKN 458
Query: 486 NDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPESFISLPKWNAKKTGSIS 545
ND +LELSRLAK+GDPKMK+ G ++F+CE+VA LDP+TFE+PE+F++LP+W+AK+TGSIS
Sbjct: 459 NDFKLELSRLAKEGDPKMKLQGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSIS 518
Query: 546 FDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKA 605
DFRTTEPNGL+LFS G+ H + D+FA+E+LDGHLYLLLDMGSG IK++A
Sbjct: 519 LDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRA 578
Query: 606 LLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPEN-KAG 664
+KVNDGEW HVDFQRDGR G+ISVN+ TP+ A G+SEILDL+ ELYLGGLPE +
Sbjct: 579 SSRKVNDGEWCHVDFQRDGRKGSISVNSRSTPFLATGDSEILDLESELYLGGLPEGGRVD 638
Query: 665 LVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPCLSNP 724
L P EVWTA L GYVGC+RDLFIDG+S+D+R +AE Q GV P CS+ET K C S P
Sbjct: 639 LPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAP 698
Query: 725 CKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDVSL 784
C+N G+CR+GWNR++CDC GTG+LGR CEREATVLSYDGSM+MKI LP MHTEAEDVSL
Sbjct: 699 CRNGGVCREGWNRFICDCIGTGFLGRVCEREATVLSYDGSMYMKIMLPNAMHTEAEDVSL 758
Query: 785 RFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNL 844
RF SQRAYG++MATTSR+SADTLRLELD G++KLTVNLDC+R+ C SKGPETLFAG+ L
Sbjct: 759 RFMSQRAYGLMMATTSRESADTLRLELDGGQMKLTVNLDCLRVGCAPSKGPETLFAGHKL 818
Query: 845 NDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETGIITERRYLSSVPSN 904
NDNEWHTVRVVRRGKSL+L+VD+ + GQMAG H RLEFHNIETGI+TERR++S VPSN
Sbjct: 819 NDNEWHTVRVVRRGKSLQLSVDNV-TVEGQMAGAHMRLEFHNIETGIMTERRFISVVPSN 877
Query: 905 FIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIADPVTFKTKSSYVALATLQAY 964
FIGHL L FNG Y+D CK+GDI YCELNARFG R I+ADPVTFK++SSY+ALATLQAY
Sbjct: 878 FIGHLSGLVFNGQPYMDQCKDGDITYCELNARFGLRAIVADPVTFKSRSSYLALATLQAY 937
Query: 965 TSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLN 1024
SMHLFFQFKTT+ DGL+L+NSG+GNDFIV+ELVKGY+HYVFDLGNG +L+KG+S+KP+N
Sbjct: 938 ASMHLFFQFKTTAPDGLLLFNSGNGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVN 997
Query: 1025 DNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLPKLVH 1084
DNQWHNV++SRD N+HT+KID++ TQ + GARNLDLK +LYIGG++K + +LPKLV
Sbjct: 998 DNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVA 1057
Query: 1085 AKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDG 1144
+++GFQGCLASVDLNGRLPDLI+DAL GQ+ERGC+GPSTTC E+SC+NQGVCLQQWDG
Sbjct: 1058 SRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDG 1117
Query: 1145 FSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAV 1204
F+CDC+MTS+ GP+CNDPGTTYIF KGG ITY WPPNDRPSTR DRLA+GFST Q+ AV
Sbjct: 1118 FTCDCTMTSYGGPVCNDPGTTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAV 1177
Query: 1205 LVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNA 1264
LVRVDS+SGLGDYL+LHI QG +GV FNVGTDDI I+E NAI++DGKYHVVRFTRSGGNA
Sbjct: 1178 LVRVDSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNA 1237
Query: 1265 TLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQATIII 1324
TLQVDSWPV ERYPAGN DNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQA I I
Sbjct: 1238 TLQVDSWPVNERYPAGNFDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIKI 1297
Query: 1325 GGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPS-SMTTESTATAM 1383
GG++QG+PFQGQ+SGLYYNGLKVL +AAE+D N+ G++RLVGE PS ++ E+TAT +
Sbjct: 1298 GGRDQGRPFQGQVSGLYYNGLKVLALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTL 1357
Query: 1384 QSEMSTSIMETTTTLATSTARRGKPPT-KEPISQTTDDILVASAECPSDDEDIDPCEPSS 1442
++M+T+IMETTTT+AT+T RRG+ PT ++ +Q TDD+LVASAECPSDDED++ CEPS+
Sbjct: 1358 LADMATTIMETTTTMATTTTRRGRSPTLRDSTTQNTDDLLVASAECPSDDEDLEECEPST 1417
Query: 1443 GG 1444
GG
Sbjct: 1418 GG 1419
Score = 164 bits (416), Expect = 5e-40
Identities = 85/102 (83%), Positives = 91/102 (89%), Gaps = 1/102 (0%)
Query: 1446 ANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHV 1505
ANPT G R P PG+ EVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSY V
Sbjct: 1612 ANPTGPGERGP-PGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQV 1670
Query: 1506 DESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV 1547
D+SRNYISNSAQSNGAVVKEK P++ K+ +K KKNKDKEYYV
Sbjct: 1671 DQSRNYISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV 1712
>gi|21166380 neurexin 2 isoform alpha-2 precursor [Homo sapiens]
Length = 1642
Score = 1861 bits (4820), Expect = 0.0
Identities = 934/1439 (64%), Positives = 1118/1439 (77%), Gaps = 113/1439 (7%)
Query: 16 LSLLLLGCWAELGSGLEFPGAEGQWTRFPKW-NACCESEMSFQLKTRSARGLVLYFDDEG 74
L LLLL A GLEF G GQW R+ +W A E+SF L+T + R L+LY DD G
Sbjct: 14 LLLLLLLALAARADGLEFGGGPGQWARYARWAGAASSGELSFSLRTNATRALLLYLDDGG 73
Query: 75 FCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVE 134
CDFLEL+L GRL+L F++ CAEPATL DTPV D WH V + R R T L +D E
Sbjct: 74 DCDFLELLLV-DGRLRLRFTLSCAEPATLQLDTPVADDRWHMVLLTRDARRTALAVDG-E 131
Query: 135 AKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQV 194
A+ EV+SKRR+M V S LFVGG+PP++R +AL TL++V+ PF+G + ++
Sbjct: 132 ARAAEVRSKRREMQVASDLFVGGIPPDVRLSAL--TLSTVKYEPPFRGLLANL------- 182
Query: 195 LPVDSGEVKLDDEPPNSGG-----GSPCEAGEEGEGGVCLNGGVCSVVDDQAV-CDCSRT 248
KL + PP G G+ + C NGG+C+V+ V CDCS T
Sbjct: 183 --------KLGERPPALLGSQGLRGATADPLCAPARNPCANGGLCTVLAPGEVGCDCSHT 234
Query: 249 GFRGKDCSQEIKFGLQCVLPVLLHDNDQGKYCCINTAKPLTEKDNNVEGLAHLMMGDQGK 308
GF GK CS+E ++ +EG AHL +
Sbjct: 235 GFGGKFCSEE---------------------------------EHPMEGPAHLTLN---- 257
Query: 309 SKGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLAL 368
S+GKEE++ATFKG+E+FCYDLS NPIQSS+DEITL+F+TLQRNGLMLHTGKSADYVNL+L
Sbjct: 258 SEGKEEFVATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHTGKSADYVNLSL 317
Query: 369 KNGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVT 428
K+GAV LVINLGSGAFEALVEPVNGKFNDNAWHDV+VTRNLRQH+GIGHAMV T
Sbjct: 318 KSGAVWLVINLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMV-------T 370
Query: 429 ISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDV 488
ISVDGILTTTGYTQEDYTMLGSDDFFY+GGSP+TADLPGSPVSNNFMGCLK+VVYKNND
Sbjct: 371 ISVDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDF 430
Query: 489 RLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPESFISLPKWNAKKTGSISFDF 548
+LELSRLAK+GDPKMK+ G ++F+CE+VA LDP+TFE+PE+F++LP+W+AK+TGSIS DF
Sbjct: 431 KLELSRLAKEGDPKMKLQGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDF 490
Query: 549 RTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLK 608
RTTEPNGL+LFS G+ H + D+FA+E+LDGHLYLLLDMGSG IK++A +
Sbjct: 491 RTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSR 550
Query: 609 KVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPEN-KAGLVF 667
KVNDGEW HVDFQRDGR G+ISVN+ TP+ A G+SEILDL+ ELYLGGLPE + L
Sbjct: 551 KVNDGEWCHVDFQRDGRKGSISVNSRSTPFLATGDSEILDLESELYLGGLPEGGRVDLPL 610
Query: 668 PTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPCLSNPCKN 727
P EVWTA L GYVGC+RDLFIDG+S+D+R +AE Q GV P CS+ET K C S PC+N
Sbjct: 611 PPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAPCRN 670
Query: 728 NGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDVSLRFR 787
G+CR+GWNR++CDC GTG+LGR CEREATVLSYDGSM+MKI LP MHTEAEDVSLRF
Sbjct: 671 GGVCREGWNRFICDCIGTGFLGRVCEREATVLSYDGSMYMKIMLPNAMHTEAEDVSLRFM 730
Query: 788 SQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDN 847
SQRAYG++MATTSR+SADTLRLELD G++KLTVNL KGPETLFAG+ LNDN
Sbjct: 731 SQRAYGLMMATTSRESADTLRLELDGGQMKLTVNL---------GKGPETLFAGHKLNDN 781
Query: 848 EWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETGIITERRYLSSVPSNFIG 907
EWHTVRVVRRGKSL+L+VD+ + GQMAG H RLEFHNIETGI+TERR++S VPSNFIG
Sbjct: 782 EWHTVRVVRRGKSLQLSVDNV-TVEGQMAGAHMRLEFHNIETGIMTERRFISVVPSNFIG 840
Query: 908 HLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIADPVTFKTKSSYVALATLQAYTSM 967
HL L FNG Y+D CK+GDI YCELNARFG R I+ADPVTFK++SSY+ALATLQAY SM
Sbjct: 841 HLSGLVFNGQPYMDQCKDGDITYCELNARFGLRAIVADPVTFKSRSSYLALATLQAYASM 900
Query: 968 HLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQ 1027
HLFFQFKTT+ DGL+L+NSG+GNDFIV+ELVKGY+HYVFDLGNG +L+KG+S+KP+NDNQ
Sbjct: 901 HLFFQFKTTAPDGLLLFNSGNGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQ 960
Query: 1028 WHNVMISRDTSNLHTVKIDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKE 1087
WHNV++SRD N+HT+KID++ TQ + GARNLDLK +LYIGG++K + +LPKLV +++
Sbjct: 961 WHNVVVSRDPGNVHTLKIDSRTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRD 1020
Query: 1088 GFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSC 1147
GFQGCLASVDLNGRLPDLI+DAL GQ+ERGC+GPSTTC E+SC+NQGVCLQQWDGF+C
Sbjct: 1021 GFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTC 1080
Query: 1148 DCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVR 1207
DC+MTS+ GP+CNDPGTTYIF KGG ITY WPPNDRPSTR DRLA+GFST Q+ AVLVR
Sbjct: 1081 DCTMTSYGGPVCNDPGTTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVR 1140
Query: 1208 VDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQ 1267
VDS+SGLGDYL+LHI QG +GV FNVGTDDI I+E NAI++DGKYHVVRFTRSGGNATLQ
Sbjct: 1141 VDSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQ 1200
Query: 1268 VDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQATIIIGGK 1327
VDSWPV ERYPA GRQLTIFNSQA I IGG+
Sbjct: 1201 VDSWPVNERYPA------------------------------GRQLTIFNSQAAIKIGGR 1230
Query: 1328 EQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPS-SMTTESTATAMQSE 1386
+QG+PFQGQ+SGLYYNGLKVL +AAE+D N+ G++RLVGE PS ++ E+TAT + ++
Sbjct: 1231 DQGRPFQGQVSGLYYNGLKVLALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLAD 1290
Query: 1387 MSTSIMETTTTLATSTARRGKPPT-KEPISQTTDDILVASAECPSDDEDIDPCEPSSGG 1444
M+T+IMETTTT+AT+T RRG+ PT ++ +Q TDD+LVASAECPSDDED++ CEPS+GG
Sbjct: 1291 MATTIMETTTTMATTTTRRGRSPTLRDSTTQNTDDLLVASAECPSDDEDLEECEPSTGG 1349
Score = 164 bits (416), Expect = 5e-40
Identities = 85/102 (83%), Positives = 91/102 (89%), Gaps = 1/102 (0%)
Query: 1446 ANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHV 1505
ANPT G R P PG+ EVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSY V
Sbjct: 1542 ANPTGPGERGP-PGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQV 1600
Query: 1506 DESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV 1547
D+SRNYISNSAQSNGAVVKEK P++ K+ +K KKNKDKEYYV
Sbjct: 1601 DQSRNYISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV 1642
>gi|21070969 neurexin 3 isoform 1 precursor [Homo sapiens]
Length = 1061
Score = 1675 bits (4338), Expect = 0.0
Identities = 820/1101 (74%), Positives = 939/1101 (85%), Gaps = 40/1101 (3%)
Query: 447 MLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIH 506
MLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNND+RLELSRLA+ D KMKI+
Sbjct: 1 MLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDIRLELSRLARIADTKMKIY 60
Query: 507 GVVAFKCENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRH 566
G V FKCENVATLDPI FETPE++ISLPKWN K+ GSISFDFRTTEPNGLILF+HGKP+
Sbjct: 61 GEVVFKCENVATLDPINFETPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQE 120
Query: 567 QKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRS 626
+KDA+ + KVDFFA+E+LDG+LYLLLDMGSGTIK+KA KK NDGEWYHVD QRDGRS
Sbjct: 121 RKDARSQKNTKVDFFAVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQRDGRS 180
Query: 627 GTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRD 686
GTISVN+ RTP+TA GESEILDL+ ++YLGGLPEN+AGL+ PTE+WTA+LNYGYVGCIRD
Sbjct: 181 GTISVNSRRTPFTASGESEILDLEGDMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRD 240
Query: 687 LFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTG 746
LFIDG+SK+IRQ+AE+Q+ AGVK SCS+ +AK C S PCKNN +C+DGWNR++CDC+GTG
Sbjct: 241 LFIDGRSKNIRQLAEMQNAAGVKSSCSRMSAKQCDSYPCKNNAVCKDGWNRFICDCTGTG 300
Query: 747 YLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADT 806
Y GR+CEREA++LSYDGSM+MKI +P+VMHTEAEDVS RF SQRAYG+L+ATTSRDSADT
Sbjct: 301 YWGRTCEREASILSYDGSMYMKIIMPMVMHTEAEDVSFRFMSQRAYGLLVATTSRDSADT 360
Query: 807 LRLELDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVD 866
LRLELD GRVKL VNLDCIRINCNSSKGPETL+AG LNDNEWHTVRVVRRGKSLKLTVD
Sbjct: 361 LRLELDGGRVKLMVNLDCIRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTVD 420
Query: 867 DQQAMTGQMAGDHTRLEFHNIETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNG 926
D A G M GDHTRLEFHNIETGI+TE+RY+S VPS+FIGHLQSL FNG+ YIDLCKNG
Sbjct: 421 DDVA-EGTMVGDHTRLEFHNIETGIMTEKRYISVVPSSFIGHLQSLMFNGLLYIDLCKNG 479
Query: 927 DIDYCELNARFGFRNIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNS 986
DIDYCEL ARFG RNIIADPVTFKTKSSY++LATLQAYTSMHLFFQFKTTS DG IL+NS
Sbjct: 480 DIDYCELKARFGLRNIIADPVTFKTKSSYLSLATLQAYTSMHLFFQFKTTSPDGFILFNS 539
Query: 987 GDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKID 1046
GDGNDFI VELVKGY+HYVFDLGNG N+IKG+S++PLNDNQWHNV+I+RD SN H++K+D
Sbjct: 540 GDGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSDRPLNDNQWHNVVITRDNSNTHSLKVD 599
Query: 1047 TKITTQITAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLI 1106
TK+ TQ+ GA+NLDLK DLY+ G+A+ Y +LPKLV +++GFQGCLASVDLNGRLPDLI
Sbjct: 600 TKVVTQVINGAKNLDLKGDLYMAGLAQGMYSNLPKLVASRDGFQGCLASVDLNGRLPDLI 659
Query: 1107 SDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTY 1166
+DAL +GQIERGCEGPSTTCQEDSC+NQGVC+QQW+GF+CDCSMTS+SG CNDPG TY
Sbjct: 660 NDALHRSGQIERGCEGPSTTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQCNDPGATY 719
Query: 1167 IFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGK 1226
IF K GG I Y WP NDRPSTR+DRLA+GFST K+ +LVR+DS+ GLGD+L+LHI QGK
Sbjct: 720 IFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGK 779
Query: 1227 IGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNER 1286
IGV FN+GT DI+I+E +NDGKYHVVRFTR+GGNATLQVD+WPV E YP
Sbjct: 780 IGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPT------- 832
Query: 1287 LAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQATIIIGGKEQGQPFQGQLSGLYYNGLK 1346
GRQLTIFN+QA I IGGK++G+ FQGQLSGLYY+GLK
Sbjct: 833 -----------------------GRQLTIFNTQAQIAIGGKDKGRLFQGQLSGLYYDGLK 869
Query: 1347 VLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSEMSTSIMETTTTLATSTARRG 1406
VLNMAAEN+ NI I G+VRLVGEVPS + T T T+M EMST++METTTT+AT+T R+
Sbjct: 870 VLNMAAENNPNIKINGSVRLVGEVPSILGTTQT-TSMPPEMSTTVMETTTTMATTTTRKN 928
Query: 1407 KPPTKEPISQTTDDILVASAECPSDDEDIDPCEPSSGGLANPTRAGGREPYPGSAEVIRE 1466
+ Q T D LV+SAEC SDDED CEPS+ ANPT G R PG++EVIRE
Sbjct: 929 RSTAS---IQPTSDDLVSSAECSSDDEDFVECEPST---ANPTEPGIRR-VPGASEVIRE 981
Query: 1467 SSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEK 1526
SSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSY VDE+RNYISNSAQSNG ++KEK
Sbjct: 982 SSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDETRNYISNSAQSNGTLMKEK 1041
Query: 1527 QPSSAKSSNKNKKNKDKEYYV 1547
Q SS KS +K +KNKD+EYYV
Sbjct: 1042 QQSS-KSGHKKQKNKDREYYV 1061
Score = 170 bits (431), Expect = 9e-42
Identities = 195/855 (22%), Positives = 342/855 (40%), Gaps = 150/855 (17%)
Query: 44 PKWNACCESEMSFQLKTRSARGLVLYFDDEGF------------CDFLELILTRGGRLQL 91
PKWN +SF +T GL+L+ + DF + L G L L
Sbjct: 88 PKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFAVELL-DGNLYL 146
Query: 92 SFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFS 151
+ NDG W+ V I+R R+ T+ ++ + + + +
Sbjct: 147 LLDMGSGTIKVKATQKKANDGEWYHVDIQRDGRSGTISVNSRRTPFT-ASGESEILDLEG 205
Query: 152 GLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEPPNS 211
+++GGLP L L + + G IRD+ ++ S ++ E N+
Sbjct: 206 DMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGR------SKNIRQLAEMQNA 259
Query: 212 GG-GSPCE--AGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEIKFGLQCVLP 268
G S C + ++ + C N VC ++ +CD
Sbjct: 260 AGVKSSCSRMSAKQCDSYPCKNNAVCKDGWNRFICD------------------------ 295
Query: 269 VLLHDNDQGKYCCINTAKPLTEKDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYD 328
C T G G++ +E I ++ GS Y
Sbjct: 296 ------------CTGT-------------------GYWGRTCEREASILSYDGSMYMKII 324
Query: 329 LSQNPIQSSSDEITLSFKTLQRNGLMLHTGK--SADYVNLALKNGAVSLVINL------- 379
+ + + +++++ F + + GL++ T SAD + L L G V L++NL
Sbjct: 325 MPM-VMHTEAEDVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLDCIRINC 383
Query: 380 -GSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTISVDGILTTT 438
S E L K NDN WH V+V R + S+ ++VD +
Sbjct: 384 NSSKGPETLY--AGQKLNDNEWHTVRVVRRGK---------------SLKLTVDDDV-AE 425
Query: 439 GYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQ 498
G D+T L +F + T S V ++F+G L+ +++ L L K
Sbjct: 426 GTMVGDHTRL---EFHNIETGIMTEKRYISVVPSSFIGHLQSLMFNG----LLYIDLCKN 478
Query: 499 GDPKMKIHGVVAFKCENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLIL 558
GD F N+ DP+TF+T S++SL A + + F F+TT P+G IL
Sbjct: 479 GDIDY-CELKARFGLRNIIA-DPVTFKTKSSYLSLATLQAYTSMHLFFQFKTTSPDGFIL 536
Query: 559 FSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALL-KKVNDGEWYH 617
F+ G DF A+E++ G+++ + D+G+G IK + +ND +W++
Sbjct: 537 FNSGDGN-------------DFIAVELVKGYIHYVFDLGNGPNVIKGNSDRPLNDNQWHN 583
Query: 618 VDFQRD-GRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALL 676
V RD + ++ V+T G ++ LDL +LY+ GL + ++
Sbjct: 584 VVITRDNSNTHSLKVDTKVVTQVING-AKNLDLKGDLYMAGLAQG----MYSNLPKLVAS 638
Query: 677 NYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWN 736
G+ GC+ + ++G+ D+ A + + ++ C + + C + C N G+C W
Sbjct: 639 RDGFQGCLASVDLNGRLPDLINDA-LHRSGQIERGC-EGPSTTCQEDSCANQGVCMQQWE 696
Query: 737 RYVCDCSGTGYLGRSC-EREATVLSYDGSMFMKIQLPV--VMHTEAEDVSLRFRSQRAYG 793
+ CDCS T Y G C + AT + + P T ++ +++ F + G
Sbjct: 697 GFTCDCSMTSYSGNQCNDPGATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDG 756
Query: 794 ILMATTSRDS-ADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTV 852
IL+ S D L+L ++ G++ + N+ + I+ + P +ND ++H V
Sbjct: 757 ILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTP--------VNDGKYHVV 808
Query: 853 RVVRRGKSLKLTVDD 867
R R G + L VD+
Sbjct: 809 RFTRNGGNATLQVDN 823
Score = 38.9 bits (89), Expect = 0.039
Identities = 28/88 (31%), Positives = 45/88 (51%), Gaps = 4/88 (4%)
Query: 65 GLVLYFDDE-GFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQF 123
G+++ D G DFL+L + +G ++ + F+I + + TPVNDG +H VR R
Sbjct: 756 GILVRIDSAPGLGDFLQLHIEQG-KIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNG 814
Query: 124 RNTTLFIDQVEAKWVEVKSKRRDMTVFS 151
N TL +D E R +T+F+
Sbjct: 815 GNATLQVDNWPVN--EHYPTGRQLTIFN 840
>gi|21070967 neurexin 1 isoform beta precursor [Homo sapiens]
Length = 442
Score = 688 bits (1776), Expect = 0.0
Identities = 355/385 (92%), Positives = 355/385 (92%), Gaps = 30/385 (7%)
Query: 1163 GTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHI 1222
GTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHI
Sbjct: 88 GTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHI 147
Query: 1223 HQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNN 1282
HQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAG
Sbjct: 148 HQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAG-- 205
Query: 1283 DNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQATIIIGGKEQGQPFQGQLSGLYY 1342
RQLTIFNSQATIIIGGKEQGQPFQGQLSGLYY
Sbjct: 206 ----------------------------RQLTIFNSQATIIIGGKEQGQPFQGQLSGLYY 237
Query: 1343 NGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSEMSTSIMETTTTLATST 1402
NGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSEMSTSIMETTTTLATST
Sbjct: 238 NGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSEMSTSIMETTTTLATST 297
Query: 1403 ARRGKPPTKEPISQTTDDILVASAECPSDDEDIDPCEPSSGGLANPTRAGGREPYPGSAE 1462
ARRGKPPTKEPISQTTDDILVASAECPSDDEDIDPCEPSSGGLANPTRAGGREPYPGSAE
Sbjct: 298 ARRGKPPTKEPISQTTDDILVASAECPSDDEDIDPCEPSSGGLANPTRAGGREPYPGSAE 357
Query: 1463 VIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDESRNYISNSAQSNGAV 1522
VIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDESRNYISNSAQSNGAV
Sbjct: 358 VIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDESRNYISNSAQSNGAV 417
Query: 1523 VKEKQPSSAKSSNKNKKNKDKEYYV 1547
VKEKQPSSAKSSNKNKKNKDKEYYV
Sbjct: 418 VKEKQPSSAKSSNKNKKNKDKEYYV 442
Score = 40.4 bits (93), Expect = 0.013
Identities = 24/93 (25%), Positives = 45/93 (48%), Gaps = 6/93 (6%)
Query: 320 KGSEYFCYDLSQNPIQSS-SDEITLSFKTLQRNGLMLHTGKSA---DYVNLALKNGAVSL 375
KG Y N S+ +D + + F T+Q+ +++ S+ DY+ L + G + +
Sbjct: 95 KGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGV 154
Query: 376 VINLGSGAFEALVEPVNGKFNDNAWHDVKVTRN 408
N+G+ + +E N ND +H V+ TR+
Sbjct: 155 KFNVGTD--DIAIEESNAIINDGKYHVVRFTRS 185
Score = 40.4 bits (93), Expect = 0.013
Identities = 37/155 (23%), Positives = 68/155 (43%), Gaps = 25/155 (16%)
Query: 66 LVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRN 125
LV G D+LEL + +G ++ + F++ + A ++ +NDG +H VR R N
Sbjct: 130 LVRVDSSSGLGDYLELHIHQG-KIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGN 188
Query: 126 TTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIR 185
TL +D +E R +T+F+ + + + + +PF+G +
Sbjct: 189 ATLQVDSWPV--IERYPAGRQLTIFN-------------SQATIIIGGKEQGQPFQGQLS 233
Query: 186 DVRVNSSQVLPVDS---------GEVKLDDEPPNS 211
+ N +VL + + G V+L E P+S
Sbjct: 234 GLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSS 268
Score = 38.1 bits (87), Expect = 0.067
Identities = 38/154 (24%), Positives = 64/154 (41%), Gaps = 18/154 (11%)
Query: 777 TEAEDVSLRFRSQRAYGILMATTSRDS-ADTLRLELDAGR--VKLTVNLDCIRINCNSSK 833
T A+ +++ F + + +L+ S D L L + G+ VK V D I I +++
Sbjct: 112 TRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAI 171
Query: 834 GPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETGIIT 893
+ND ++H VR R G + L VD + AG +L N + II
Sbjct: 172 ----------INDGKYHVVRFTRSGGNATLQVDSWPVIERYPAG--RQLTIFNSQATIII 219
Query: 894 ERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGD 927
+ F G L L +NG+ +++ D
Sbjct: 220 GGK---EQGQPFQGQLSGLYYNGLKVLNMAAEND 250
Score = 32.0 bits (71), Expect = 4.8
Identities = 19/81 (23%), Positives = 41/81 (50%), Gaps = 2/81 (2%)
Query: 579 DFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNT--LRT 636
D+ + + G + + ++G+ I I+ +NDG+++ V F R G + T+ V++ +
Sbjct: 141 DYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIE 200
Query: 637 PYTAPGESEILDLDDELYLGG 657
Y A + I + + +GG
Sbjct: 201 RYPAGRQLTIFNSQATIIIGG 221
>gi|157427673 neurexin 3 isoform 3 precursor [Homo sapiens]
Length = 459
Score = 518 bits (1333), Expect = e-146
Identities = 265/385 (68%), Positives = 311/385 (80%), Gaps = 9/385 (2%)
Query: 1163 GTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHI 1222
G TYIF K GG I Y WP NDRPSTR+DRLA+GFST K+ +LVR+DS+ GLGD+L+LHI
Sbjct: 84 GATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHI 143
Query: 1223 HQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNN 1282
QGKIGV FN+GT DI+I+E +NDGKYHVVRFTR+GGNATLQVD+WPV E YP GN
Sbjct: 144 EQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGNT 203
Query: 1283 DNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQATIIIGGKEQGQPFQGQLSGLYY 1342
DNER + +Q+IP++ R V+EWL +KGRQLTIFN+QA I IGGK++G+ FQGQLSGLYY
Sbjct: 204 DNERFQMVKQKIPFKYNRPVEEWLQEKGRQLTIFNTQAQIAIGGKDKGRLFQGQLSGLYY 263
Query: 1343 NGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSEMSTSIMETTTTLATST 1402
+GLKVLNMAAEN+ NI I G+VRLVGEVPS + T T T+M EMST++METTTT+AT+T
Sbjct: 264 DGLKVLNMAAENNPNIKINGSVRLVGEVPSILGTTQT-TSMPPEMSTTVMETTTTMATTT 322
Query: 1403 ARRGKPPTKEPISQTTDDILVASAECPSDDEDIDPCEPSSGGLANPTRAGGREPYPGSAE 1462
R+ + Q T D LV+SAEC SDDED CEPS+ ANPT G R PG++E
Sbjct: 323 TRKNRSTAS---IQPTSDDLVSSAECSSDDEDFVECEPST---ANPTEPGIRR-VPGASE 375
Query: 1463 VIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDESRNYISNSAQSNGAV 1522
VIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSY VDE+RNYISNSAQSNG +
Sbjct: 376 VIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDETRNYISNSAQSNGTL 435
Query: 1523 VKEKQPSSAKSSNKNKKNKDKEYYV 1547
+KEKQ SS KS +K +KNKD+EYYV
Sbjct: 436 MKEKQQSS-KSGHKKQKNKDREYYV 459
Score = 38.5 bits (88), Expect = 0.051
Identities = 24/68 (35%), Positives = 38/68 (55%), Gaps = 2/68 (2%)
Query: 65 GLVLYFDDE-GFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQF 123
G+++ D G DFL+L + +G ++ + F+I + + TPVNDG +H VR R
Sbjct: 124 GILVRIDSAPGLGDFLQLHIEQG-KIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNG 182
Query: 124 RNTTLFID 131
N TL +D
Sbjct: 183 GNATLQVD 190
Score = 37.4 bits (85), Expect = 0.11
Identities = 23/92 (25%), Positives = 45/92 (48%), Gaps = 9/92 (9%)
Query: 777 TEAEDVSLRFRSQRAYGILMATTSRDS-ADTLRLELDAGRVKLTVNLDCIRINCNSSKGP 835
T ++ +++ F + GIL+ S D L+L ++ G++ + N+ + I+ + P
Sbjct: 108 TRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTP 167
Query: 836 ETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDD 867
+ND ++H VR R G + L VD+
Sbjct: 168 --------VNDGKYHVVRFTRNGGNATLQVDN 191
Score = 36.2 bits (82), Expect = 0.25
Identities = 39/179 (21%), Positives = 76/179 (42%), Gaps = 33/179 (18%)
Query: 474 FMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPIT-FETPESFIS 532
F GC+ V+ +++V S + G H K +V PI+ + +P S
Sbjct: 25 FWGCIVSSVWSSSNVASSSSTSSSPGSHSQHEHHFHGSKHHSV----PISIYRSPVSL-- 78
Query: 533 LPKWNAKKTGSISFDFRTTEPNGLILFS---HGKPRHQKD---------AKHPQMIKVD- 579
+ G + + GLIL++ + +P + D K ++++D
Sbjct: 79 -------RGGHAGATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDS 131
Query: 580 ------FFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVN 632
F + + G + ++ ++G+ I IK VNDG+++ V F R+G + T+ V+
Sbjct: 132 APGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVD 190
Score = 35.8 bits (81), Expect = 0.33
Identities = 24/76 (31%), Positives = 43/76 (56%), Gaps = 4/76 (5%)
Query: 973 FKTTSLDGLIL-YNSGDG-NDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHN 1030
F TT DG+++ +S G DF+ + + +G + VF++G IK P+ND ++H
Sbjct: 117 FSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIK-EERTPVNDGKYHV 175
Query: 1031 VMISRDTSNLHTVKID 1046
V +R+ N T+++D
Sbjct: 176 VRFTRNGGNA-TLQVD 190
>gi|41350305 neurexin 3 isoform 2 precursor [Homo sapiens]
Length = 432
Score = 473 bits (1216), Expect = e-133
Identities = 251/385 (65%), Positives = 290/385 (75%), Gaps = 36/385 (9%)
Query: 1163 GTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHI 1222
G TYIF K GG I Y WP NDRPSTR+DRLA+GFST K+ +LVR+DS+ GLGD+L+LHI
Sbjct: 84 GATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHI 143
Query: 1223 HQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNN 1282
QGKIGV FN+GT DI+I+E +NDGKYHVVRFTR+GGNATLQVD+WPV E YP
Sbjct: 144 EQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPT--- 200
Query: 1283 DNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQATIIIGGKEQGQPFQGQLSGLYY 1342
GRQLTIFN+QA I IGGK++G+ FQGQLSGLYY
Sbjct: 201 ---------------------------GRQLTIFNTQAQIAIGGKDKGRLFQGQLSGLYY 233
Query: 1343 NGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSEMSTSIMETTTTLATST 1402
+GLKVLNMAAEN+ NI I G+VRLVGEVPS + T T T+M EMST++METTTT+AT+T
Sbjct: 234 DGLKVLNMAAENNPNIKINGSVRLVGEVPSILGTTQT-TSMPPEMSTTVMETTTTMATTT 292
Query: 1403 ARRGKPPTKEPISQTTDDILVASAECPSDDEDIDPCEPSSGGLANPTRAGGREPYPGSAE 1462
R+ + Q T D LV+SAEC SDDED CEPS+G ANPT G R PG++E
Sbjct: 293 TRKNRSTAS---IQPTSDDLVSSAECSSDDEDFVECEPSTGRSANPTEPGIRR-VPGASE 348
Query: 1463 VIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDESRNYISNSAQSNGAV 1522
VIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSY VDE+RNYISNSAQSNG +
Sbjct: 349 VIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDETRNYISNSAQSNGTL 408
Query: 1523 VKEKQPSSAKSSNKNKKNKDKEYYV 1547
+KEKQ SS KS +K +KNKD+EYYV
Sbjct: 409 MKEKQQSS-KSGHKKQKNKDREYYV 432
Score = 38.9 bits (89), Expect = 0.039
Identities = 28/88 (31%), Positives = 45/88 (51%), Gaps = 4/88 (4%)
Query: 65 GLVLYFDDE-GFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQF 123
G+++ D G DFL+L + +G ++ + F+I + + TPVNDG +H VR R
Sbjct: 124 GILVRIDSAPGLGDFLQLHIEQG-KIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNG 182
Query: 124 RNTTLFIDQVEAKWVEVKSKRRDMTVFS 151
N TL +D E R +T+F+
Sbjct: 183 GNATLQVDNWPVN--EHYPTGRQLTIFN 208
Score = 37.7 bits (86), Expect = 0.087
Identities = 43/206 (20%), Positives = 86/206 (41%), Gaps = 35/206 (16%)
Query: 474 FMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPIT-FETPESFIS 532
F GC+ V+ +++V S + G H K +V PI+ + +P S
Sbjct: 25 FWGCIVSSVWSSSNVASSSSTSSSPGSHSQHEHHFHGSKHHSV----PISIYRSPVSL-- 78
Query: 533 LPKWNAKKTGSISFDFRTTEPNGLILFS---HGKPRHQKD---------AKHPQMIKVD- 579
+ G + + GLIL++ + +P + D K ++++D
Sbjct: 79 -------RGGHAGATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDS 131
Query: 580 ------FFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNT 633
F + + G + ++ ++G+ I IK VNDG+++ V F R+G + T+ V+
Sbjct: 132 APGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDN 191
Query: 634 --LRTPYTAPGESEILDLDDELYLGG 657
+ Y + I + ++ +GG
Sbjct: 192 WPVNEHYPTGRQLTIFNTQAQIAIGG 217
Score = 37.4 bits (85), Expect = 0.11
Identities = 23/92 (25%), Positives = 45/92 (48%), Gaps = 9/92 (9%)
Query: 777 TEAEDVSLRFRSQRAYGILMATTSRDS-ADTLRLELDAGRVKLTVNLDCIRINCNSSKGP 835
T ++ +++ F + GIL+ S D L+L ++ G++ + N+ + I+ + P
Sbjct: 108 TRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTP 167
Query: 836 ETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDD 867
+ND ++H VR R G + L VD+
Sbjct: 168 --------VNDGKYHVVRFTRNGGNATLQVDN 191
Score = 37.0 bits (84), Expect = 0.15
Identities = 30/106 (28%), Positives = 54/106 (50%), Gaps = 7/106 (6%)
Query: 973 FKTTSLDGLIL-YNSGDG-NDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHN 1030
F TT DG+++ +S G DF+ + + +G + VF++G IK P+ND ++H
Sbjct: 117 FSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIK-EERTPVNDGKYHV 175
Query: 1031 VMISRDTSNLHTVKIDTKITTQITAGARNLDL---KSDLYIGGVAK 1073
V +R+ N T+++D + R L + ++ + IGG K
Sbjct: 176 VRFTRNGGNA-TLQVDNWPVNEHYPTGRQLTIFNTQAQIAIGGKDK 220
>gi|21166382 neurexin 2 isoform beta precursor [Homo sapiens]
Length = 666
Score = 439 bits (1130), Expect = e-123
Identities = 215/284 (75%), Positives = 250/284 (88%), Gaps = 2/284 (0%)
Query: 1163 GTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHI 1222
GTTYIF KGG ITY WPPNDRPSTR DRLA+GFST Q+ AVLVRVDS+SGLGDYL+LHI
Sbjct: 90 GTTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHI 149
Query: 1223 HQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNN 1282
QG +GV FNVGTDDI I+E NAI++DGKYHVVRFTRSGGNATLQVDSWPV ERYPAGN
Sbjct: 150 DQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNF 209
Query: 1283 DNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQATIIIGGKEQGQPFQGQLSGLYY 1342
DNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQA I IGG++QG+PFQGQ+SGLYY
Sbjct: 210 DNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYY 269
Query: 1343 NGLKVLNMAAENDANIAIVGNVRLVGEVPS-SMTTESTATAMQSEMSTSIMETTTTLATS 1401
NGLKVL +AAE+D N+ G++RLVGE PS ++ E+TAT + ++M+T+IMETTTT+AT+
Sbjct: 270 NGLKVLALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATT 329
Query: 1402 TARRGKPPT-KEPISQTTDDILVASAECPSDDEDIDPCEPSSGG 1444
T RRG+ PT ++ +Q TDD+LVASAECPSDDED++ CEPS+GG
Sbjct: 330 TTRRGRSPTLRDSTTQNTDDLLVASAECPSDDEDLEECEPSTGG 373
Score = 164 bits (416), Expect = 5e-40
Identities = 85/102 (83%), Positives = 91/102 (89%), Gaps = 1/102 (0%)
Query: 1446 ANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHV 1505
ANPT G R P PG+ EVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSY V
Sbjct: 566 ANPTGPGERGP-PGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQV 624
Query: 1506 DESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV 1547
D+SRNYISNSAQSNGAVVKEK P++ K+ +K KKNKDKEYYV
Sbjct: 625 DQSRNYISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV 666
Score = 37.7 bits (86), Expect = 0.087
Identities = 23/93 (24%), Positives = 45/93 (48%), Gaps = 6/93 (6%)
Query: 320 KGSEYFCYDLSQNPIQSSS-DEITLSFKTLQRNGLMLHTGKSA---DYVNLALKNGAVSL 375
KG Y N S+ D + + F T QR+ +++ ++ DY+ L + G V +
Sbjct: 97 KGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGV 156
Query: 376 VINLGSGAFEALVEPVNGKFNDNAWHDVKVTRN 408
+ N+G+ + ++ N +D +H V+ TR+
Sbjct: 157 IFNVGTD--DITIDEPNAIVSDGKYHVVRFTRS 187
>gi|47519929 cell recognition molecule CASPR3 [Homo sapiens]
Length = 1288
Score = 219 bits (557), Expect = 2e-56
Identities = 251/1037 (24%), Positives = 431/1037 (41%), Gaps = 182/1037 (17%)
Query: 316 IATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHT-GKSADYVNLALKNGAVS 374
+ F G Y L + P++ D I+L FK +Q NG++LH G+ +++ L L G +
Sbjct: 183 VVYFDGQSALLYRLDKKPLKPIRDVISLKFKAMQSNGILLHREGQHGNHITLELIKGKLV 242
Query: 375 LVINLGSGAFEALVEPVN----GKFNDNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTIS 430
+N G+ + + PV +D WH V ++ L V +
Sbjct: 243 FFLNSGNAKLPSTIAPVTLTLGSLLDDQHWHSV---------------LIELLDTQVNFT 287
Query: 431 VDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVS---NNFMGCLKEVVYKNND 487
VD T + D + L + GG P+ PG + +F GCL+ + Y D
Sbjct: 288 VDKH-THHFQAKGDSSYLDLNFEISFGGIPT----PGRSRAFRRKSFHGCLENLYYNGVD 342
Query: 488 VRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPESFISLPKWNAKKTGSISFD 547
V + LAK+ P++ + G V+F C T+ P+TF + S+++LP + + S++F
Sbjct: 343 V----TELAKKHKPQILMMGNVSFSCPQPQTV-PVTFLSSRSYLALPGNSGEDKVSVTFQ 397
Query: 548 FRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALL 607
FRT G +LF G+ R + F + + DG L L L + +
Sbjct: 398 FRTWNRAGHLLF--GELRRGSGS----------FVLFLKDGKLKLSLFQPGQSPRNVTAG 445
Query: 608 KKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVF 667
+NDG+W+ V F + V+ P + ++D D Y GG +N +G
Sbjct: 446 AGLNDGQWHSVSFSAKWSHMNVVVDD--DTAVQPLVAVLIDSGDTYYFGGCLDNSSGSGC 503
Query: 668 PTEVWTALLNYGYVGCIRDLFIDGQSKD--IRQMAEVQSTAGVKPSCSKETAKPCLSNPC 725
+ + G+ GC+R + I ++ D + Q + S ++ T + CL + C
Sbjct: 504 KSPLG------GFQGCLRLITIGDKAVDPILVQQGALGSFRDLQIDSCGITDR-CLPSYC 556
Query: 726 KNNGMCRDGWNRYVCDCSGTGYLG---------RSCEREAT--------VLSYDGS---- 764
++ G C W+ + CDC GTGY G +SCE + DGS
Sbjct: 557 EHGGECSQSWDTFSCDCLGTGYTGETCHSSLYEQSCEAHKHRGNPSGLYYIDADGSGPLG 616
Query: 765 -------MFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVK 817
M VV H + V+LR + SA + AG+++
Sbjct: 617 PFLVYCNMTADAAWTVVQHGGPDAVTLRGAP---------SGHPRSAVSFAYAAGAGQLR 667
Query: 818 LTVNL-----DCIRINCNSSKGPE----TLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQ 868
VNL + + C +++ P+ T + + NE HT S ++ D
Sbjct: 668 SAVNLAERCEQRLALRCGTARRPDSRDGTPLSWWVGRTNETHT--------SWGGSLPDA 719
Query: 869 QAMTGQMAGDHTRLEFH-NIETG---------IITERRYL--SSVPSNFIGHLQSLTFNG 916
Q T + G+ +++ N + G +++++ +L + + G S
Sbjct: 720 QKCTCGLEGNCIDSQYYCNCDAGRNEWTSDTIVLSQKEHLPVTQIVMTDAGRPHSEAAYT 779
Query: 917 MAYIDLCKNGDIDYCELNARFGFRNIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTT 976
+ + LC+ GD + + +F T++SY+ + + F FKTT
Sbjct: 780 LGPL-LCR-GDQSFW-------------NSASFNTETSYLHFPAFHGELTADVCFFFKTT 824
Query: 977 SLDGLILYNSGDGNDFIVVEL-VKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISR 1035
G+ + N G DFI +EL + + FD+GNG + S P NDNQWH+V R
Sbjct: 825 VSSGVFMENLGI-TDFIRIELRAPTEVTFSFDVGNGPCEVTVQSPTPFNDNQWHHVRAER 883
Query: 1036 DT--SNLHTVKIDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCL 1093
+ ++L ++ K+ G L L S L+IGG A + GF GC+
Sbjct: 884 NVKGASLQVDQLPQKMQPAPADGHVRLQLNSQLFIGGTATR-----------QRGFLGCI 932
Query: 1094 ASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTS 1153
S+ LNG DL A G +E GC G +T C N G C ++ G +CDC+ ++
Sbjct: 933 RSLQLNGVALDLEERATVTPG-VEPGCAGHCST-YGHLCRNGGRCREKRRGVTCDCAFSA 990
Query: 1154 FSGPLCNDPGTTYIFSKGGGQITYKWPPN----------------DRPSTRADRLAIGFS 1197
+ GP C++ + Y + G +TY + + D TR + + + F
Sbjct: 991 YDGPFCSNEISAYFAT--GSSMTYHFQEHYTLSENSSSLVSSLHRDVTLTR-EMITLSFR 1047
Query: 1198 TVQKEAVLVRVDSSSGLGDYLELHI-HQGKIGVKFNV----GTDDIAIEESNAIINDGKY 1252
T + ++L+ V SS +YL + + + G + +++ + D + N + DG+
Sbjct: 1048 TTRTPSLLLYV--SSFYEEYLSVILANNGSLQIRYKLDRHQNPDAFTFDFKN--MADGQL 1103
Query: 1253 HVVRFTRSGGNATLQVD 1269
H V+ R ++V+
Sbjct: 1104 HQVKINREEAVVMVEVN 1120
Score = 118 bits (296), Expect = 4e-26
Identities = 116/419 (27%), Positives = 182/419 (43%), Gaps = 21/419 (5%)
Query: 752 CEREATVLSYDGSMFMKIQLPVVMHTEAEDV-SLRFRSQRAYGILMATTSRDSADTLRLE 810
C ++ V+ +DG + +L DV SL+F++ ++ GIL+ + + + LE
Sbjct: 177 CAYKSEVVYFDGQSALLYRLDKKPLKPIRDVISLKFKAMQSNGILLHREGQHG-NHITLE 235
Query: 811 LDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQA 870
L G++ +N ++ S+ P TL G L+D WH+V + + TVD +
Sbjct: 236 LIKGKLVFFLNSGNAKLP--STIAPVTLTLGSLLDDQHWHSVLIELLDTQVNFTVD-KHT 292
Query: 871 MTGQMAGDHTRLEFHNIET---GIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGD 927
Q GD + L+ N E GI T R + +F G L++L +NG+ +L K
Sbjct: 293 HHFQAKGDSSYLDL-NFEISFGGIPTPGRSRAFRRKSFHGCLENLYYNGVDVTELAKKHK 351
Query: 928 IDYCEL-NARFGFRNIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNS 986
+ N F PVTF + SY+AL + + FQF+T + G +L+
Sbjct: 352 PQILMMGNVSFSCPQPQTVPVTFLSSRSYLALPGNSGEDKVSVTFQFRTWNRAGHLLFGE 411
Query: 987 -GDGNDFIVVELVKGYLHY-VFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVK 1044
G+ V+ L G L +F G + + LND QWH+V S S+++ V
Sbjct: 412 LRRGSGSFVLFLKDGKLKLSLFQPGQSPRNVTAGAG--LNDGQWHSVSFSAKWSHMNVVV 469
Query: 1045 IDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPD 1104
D + A +D Y GG + S K GFQGCL + + + D
Sbjct: 470 DDDTAVQPLVAVL--IDSGDTYYFGGCLDNSSGSGCK--SPLGGFQGCLRLITIGDKAVD 525
Query: 1105 LI---SDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCN 1160
I AL ++ G + C C + G C Q WD FSCDC T ++G C+
Sbjct: 526 PILVQQGALGSFRDLQIDSCGITDRCLPSYCEHGGECSQSWDTFSCDCLGTGYTGETCH 584
Score = 67.8 bits (164), Expect = 8e-11
Identities = 58/226 (25%), Positives = 96/226 (42%), Gaps = 28/226 (12%)
Query: 37 EGQWTRFPKWNACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIF 96
E + FP ++ +++ F KT + G+ + ++ G DF+ + L + SF +
Sbjct: 800 ETSYLHFPAFHGELTADVCFFFKTTVSSGV--FMENLGITDFIRIELRAPTEVTFSFDVG 857
Query: 97 CAE-PATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRR-DMTVFSGLF 154
T+ + TP ND WH VR R + +L +DQ+ K + + + S LF
Sbjct: 858 NGPCEVTVQSPTPFNDNQWHHVRAERNVKGASLQVDQLPQKMQPAPADGHVRLQLNSQLF 917
Query: 155 VGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGG 214
+GG + R+R F G IR +++N + L++ + G
Sbjct: 918 IGG--------------TATRQR-GFLGCIRSLQLNGV--------ALDLEERATVTPGV 954
Query: 215 SPCEAGE-EGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEI 259
P AG G +C NGG C CDC+ + + G CS EI
Sbjct: 955 EPGCAGHCSTYGHLCRNGGRCREKRRGVTCDCAFSAYDGPFCSNEI 1000
Score = 47.0 bits (110), Expect = 1e-04
Identities = 49/217 (22%), Positives = 86/217 (39%), Gaps = 34/217 (15%)
Query: 54 MSFQLKTRSARGLVLYFD-DEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDG 112
++FQ +T + G +L+ + G F+ + + G+L+LS P + A +NDG
Sbjct: 394 VTFQFRTWNRAGHLLFGELRRGSGSFV--LFLKDGKLKLSLFQPGQSPRNVTAGAGLNDG 451
Query: 113 AWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSG--LFVGGLPPELRAAALKLT 170
WHSV ++ + + +D A V + + SG + GG + K
Sbjct: 452 QWHSVSFSAKWSHMNVVVDDDTAVQPLVA-----VLIDSGDTYYFGGCLDNSSGSGCKSP 506
Query: 171 LASVREREPFKGWIRDVRVNSSQVLPV--------DSGEVKLDDEPPNSGGGSPCEAGEE 222
L F+G +R + + V P+ ++++D C +
Sbjct: 507 LGG------FQGCLRLITIGDKAVDPILVQQGALGSFRDLQIDS----------CGITDR 550
Query: 223 GEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEI 259
C +GG CS D CDC TG+ G+ C +
Sbjct: 551 CLPSYCEHGGECSQSWDTFSCDCLGTGYTGETCHSSL 587
Score = 32.7 bits (73), Expect = 2.8
Identities = 18/56 (32%), Positives = 28/56 (50%), Gaps = 2/56 (3%)
Query: 1333 FQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSEMS 1388
F G L LYYNG+ V +A ++ I ++GNV P T T + +S ++
Sbjct: 329 FHGCLENLYYNGVDVTELAKKHKPQILMMGNVSF--SCPQPQTVPVTFLSSRSYLA 382
Score = 31.6 bits (70), Expect = 6.2
Identities = 23/82 (28%), Positives = 41/82 (50%), Gaps = 3/82 (3%)
Query: 1213 GLGDYLELHIHQG-KIGVKFNVGTDDIAIE-ESNAIINDGKYHVVRFTRSGGNATLQVDS 1270
G+ D++ + + ++ F+VG + +S ND ++H VR R+ A+LQVD
Sbjct: 835 GITDFIRIELRAPTEVTFSFDVGNGPCEVTVQSPTPFNDNQWHHVRAERNVKGASLQVDQ 894
Query: 1271 WPVIERYPAGNNDNERLAIARQ 1292
P + PA + + RL + Q
Sbjct: 895 LPQ-KMQPAPADGHVRLQLNSQ 915
>gi|239743754 PREDICTED: hypothetical protein LOC389722 isoform 1
[Homo sapiens]
Length = 1288
Score = 214 bits (545), Expect = 5e-55
Identities = 250/1033 (24%), Positives = 428/1033 (41%), Gaps = 174/1033 (16%)
Query: 316 IATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHT-GKSADYVNLALKNGAVS 374
+ F G Y L + P++ D I+L FK +Q NG++LH G+ +++ L L G +
Sbjct: 183 VVYFDGQSALLYTLDKKPLKPIRDVISLKFKAMQSNGILLHREGQHGNHITLELIKGKLV 242
Query: 375 LVINLGSGAFEALVEPVN----GKFNDNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTIS 430
+N G+ + + PV +D WH V ++ L V +
Sbjct: 243 FFLNSGNAKLPSTIAPVTLTLGSLLDDQHWHSV---------------LIELLDTQVNFT 287
Query: 431 VDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSP---VSNNFMGCLKEVVYKNND 487
VD T + D + L + GG S PG +F GCL+ + Y D
Sbjct: 288 VDKH-THHFQAKGDSSNLDLNFEISFGGILS----PGRSRAFTRKSFHGCLENLYYNGVD 342
Query: 488 VRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPESFISLPKWNAKKTGSISFD 547
V + LAK+ P++ + G V+F C T+ P+TF + S+++LP + + S++F
Sbjct: 343 V----TELAKKHKPQILMMGNVSFSCPQPQTV-PVTFLSSRSYLALPGNSGEDKVSVTFQ 397
Query: 548 FRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALL 607
FRT G +LF G+ + + F + + DG L L L + +
Sbjct: 398 FRTWNRAGHLLF--GELQRGSGS----------FVLFLKDGKLKLSLFQAGQSPRNVTAG 445
Query: 608 KKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVF 667
+NDG+W+ V F + V+ P + ++D D Y GG N +G
Sbjct: 446 AGLNDGQWHSVSFSAKWSHMNVVVDD--DTAVQPLVAVLIDSGDTYYFGGCLGNSSGSGC 503
Query: 668 PTEVWTALLNYGYVGCIRDLFIDGQSKD--IRQMAEVQSTAGVKPSCSKETAKPCLSNPC 725
+ + G+ GC+R + I ++ D + Q + S ++ T + CL + C
Sbjct: 504 KSPLG------GFQGCLRLITIGDKAVDPILVQQGALGSFRDLQIDSCGITDR-CLPSYC 556
Query: 726 KNNGMCRDGWNRYVCDCSGTGYLG---------RSCEREAT--------VLSYDGS---- 764
++ G C W+ + CDC GTGY G +SCE + DGS
Sbjct: 557 EHGGECSQSWDTFSCDCLGTGYTGETCHSSLYEQSCEAHKHRGNPSGLYYIDADGSGPLG 616
Query: 765 -------MFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVK 817
M VV H + V+LR + + + SA + AG+++
Sbjct: 617 PFLVYCNMTADSAWTVVRHGGPDAVTLR-GAPSGHPL--------SAVSFAYAAGAGQLR 667
Query: 818 LTVNL-----DCIRINCNSSKGPE----TLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQ 868
VNL + + C +++ P+ T + + NE HT S ++ D
Sbjct: 668 AAVNLAERCEQRLALRCGTARRPDSRDGTPLSWWVGRTNETHT--------SWGGSLPDA 719
Query: 869 QAMTGQMAGDHTRLEFH-NIETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCK-NG 926
Q T + G+ +++ N + G + + S + + + L + D + +
Sbjct: 720 QKCTCGLEGNCIDSQYYCNCDAG---QNEWTSD--TIVLSQKEHLPVTQIVMTDTGQPHS 774
Query: 927 DIDY------CELNARFGFRNIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDG 980
+ DY C + F + +F T++SY+ + + F FKTT G
Sbjct: 775 EADYTLGPLLCRGDKSFW------NSASFNTETSYLHFPAFHGELTADVCFFFKTTVSSG 828
Query: 981 LILYNSGDGNDFIVVEL-VKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDT-- 1037
+ + N G DFI +EL + + FD+GNG + S P NDNQWH+V R+
Sbjct: 829 VFMENLGI-TDFIRIELRAPTEVTFSFDVGNGPCEVTVQSPTPFNDNQWHHVRAERNVKG 887
Query: 1038 SNLHTVKIDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVD 1097
++L ++ K+ G L L S L+IGG A + GF GC+ S+
Sbjct: 888 ASLQVDQLPQKMQPAPADGHVRLQLNSQLFIGGTATR-----------QRGFLGCIRSLQ 936
Query: 1098 LNGRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGP 1157
LNG DL A G +E GC G +T C N G C ++ G +CDC+ +++ GP
Sbjct: 937 LNGVALDLEERATVTPG-VEPGCAGHCST-YGHLCRNGGRCREKRRGVTCDCAFSAYDGP 994
Query: 1158 LCNDPGTTYIFSKGGGQITYKWPPN----------------DRPSTRADRLAIGFSTVQK 1201
C++ + Y + G +TY + + D TR + + + F T +
Sbjct: 995 FCSNEISAYFAT--GSSMTYHFQEHYTLSENSSSLVSSLYRDVTLTR-EMITLSFRTTRS 1051
Query: 1202 EAVLVRVDSSSGLGDYLELHI-HQGKIGVKFNV----GTDDIAIEESNAIINDGKYHVVR 1256
++L+ V SS +YL + + + G + +++ + D + N + DG+ H V+
Sbjct: 1052 PSLLLYV--SSFYEEYLSVILANNGSLQIRYKLDRHQNPDAFTFDFKN--MADGQLHQVK 1107
Query: 1257 FTRSGGNATLQVD 1269
R ++V+
Sbjct: 1108 INREEAVVMVEVN 1120
Score = 120 bits (301), Expect = 1e-26
Identities = 115/419 (27%), Positives = 182/419 (43%), Gaps = 21/419 (5%)
Query: 752 CEREATVLSYDGSMFMKIQLPVVMHTEAEDV-SLRFRSQRAYGILMATTSRDSADTLRLE 810
C ++ V+ +DG + L DV SL+F++ ++ GIL+ + + + LE
Sbjct: 177 CAYKSEVVYFDGQSALLYTLDKKPLKPIRDVISLKFKAMQSNGILLHREGQHG-NHITLE 235
Query: 811 LDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQA 870
L G++ +N ++ S+ P TL G L+D WH+V + + TVD +
Sbjct: 236 LIKGKLVFFLNSGNAKLP--STIAPVTLTLGSLLDDQHWHSVLIELLDTQVNFTVD-KHT 292
Query: 871 MTGQMAGDHTRLEFHNIET---GIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGD 927
Q GD + L+ N E GI++ R + +F G L++L +NG+ +L K
Sbjct: 293 HHFQAKGDSSNLDL-NFEISFGGILSPGRSRAFTRKSFHGCLENLYYNGVDVTELAKKHK 351
Query: 928 IDYCEL-NARFGFRNIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNS 986
+ N F PVTF + SY+AL + + FQF+T + G +L+
Sbjct: 352 PQILMMGNVSFSCPQPQTVPVTFLSSRSYLALPGNSGEDKVSVTFQFRTWNRAGHLLFGE 411
Query: 987 GD-GNDFIVVELVKGYLHY-VFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVK 1044
G+ V+ L G L +F G + + LND QWH+V S S+++ V
Sbjct: 412 LQRGSGSFVLFLKDGKLKLSLFQAGQSPRNVTAGAG--LNDGQWHSVSFSAKWSHMNVVV 469
Query: 1045 IDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPD 1104
D + A +D Y GG + S K GFQGCL + + + D
Sbjct: 470 DDDTAVQPLVAVL--IDSGDTYYFGGCLGNSSGSGCK--SPLGGFQGCLRLITIGDKAVD 525
Query: 1105 LI---SDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCN 1160
I AL ++ G + C C + G C Q WD FSCDC T ++G C+
Sbjct: 526 PILVQQGALGSFRDLQIDSCGITDRCLPSYCEHGGECSQSWDTFSCDCLGTGYTGETCH 584
Score = 67.8 bits (164), Expect = 8e-11
Identities = 58/226 (25%), Positives = 96/226 (42%), Gaps = 28/226 (12%)
Query: 37 EGQWTRFPKWNACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIF 96
E + FP ++ +++ F KT + G+ + ++ G DF+ + L + SF +
Sbjct: 800 ETSYLHFPAFHGELTADVCFFFKTTVSSGV--FMENLGITDFIRIELRAPTEVTFSFDVG 857
Query: 97 CAE-PATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRR-DMTVFSGLF 154
T+ + TP ND WH VR R + +L +DQ+ K + + + S LF
Sbjct: 858 NGPCEVTVQSPTPFNDNQWHHVRAERNVKGASLQVDQLPQKMQPAPADGHVRLQLNSQLF 917
Query: 155 VGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGG 214
+GG + R+R F G IR +++N + L++ + G
Sbjct: 918 IGG--------------TATRQR-GFLGCIRSLQLNGV--------ALDLEERATVTPGV 954
Query: 215 SPCEAGE-EGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEI 259
P AG G +C NGG C CDC+ + + G CS EI
Sbjct: 955 EPGCAGHCSTYGHLCRNGGRCREKRRGVTCDCAFSAYDGPFCSNEI 1000
Score = 48.1 bits (113), Expect = 6e-05
Identities = 49/217 (22%), Positives = 86/217 (39%), Gaps = 34/217 (15%)
Query: 54 MSFQLKTRSARGLVLYFD-DEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDG 112
++FQ +T + G +L+ + G F+ + + G+L+LS P + A +NDG
Sbjct: 394 VTFQFRTWNRAGHLLFGELQRGSGSFV--LFLKDGKLKLSLFQAGQSPRNVTAGAGLNDG 451
Query: 113 AWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSG--LFVGGLPPELRAAALKLT 170
WHSV ++ + + +D A V + + SG + GG + K
Sbjct: 452 QWHSVSFSAKWSHMNVVVDDDTAVQPLVA-----VLIDSGDTYYFGGCLGNSSGSGCKSP 506
Query: 171 LASVREREPFKGWIRDVRVNSSQVLPV--------DSGEVKLDDEPPNSGGGSPCEAGEE 222
L F+G +R + + V P+ ++++D C +
Sbjct: 507 LGG------FQGCLRLITIGDKAVDPILVQQGALGSFRDLQIDS----------CGITDR 550
Query: 223 GEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEI 259
C +GG CS D CDC TG+ G+ C +
Sbjct: 551 CLPSYCEHGGECSQSWDTFSCDCLGTGYTGETCHSSL 587
Score = 39.3 bits (90), Expect = 0.030
Identities = 51/210 (24%), Positives = 85/210 (40%), Gaps = 34/210 (16%)
Query: 206 DEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEIKFGLQC 265
+E S GGS +A + C G + +D Q C+C + + S I +
Sbjct: 706 NETHTSWGGSLPDAQK------CTCGLEGNCIDSQYYCNCDAG--QNEWTSDTIVLSQKE 757
Query: 266 VLPVLLHDNDQGKYCCINTAKPLTEKDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYF 325
LPV + +T +P +E D + L L GD+ +F S F
Sbjct: 758 HLPVT-------QIVMTDTGQPHSEADYTLGPL--LCRGDK-----------SFWNSASF 797
Query: 326 CYDLSQNPIQSSSDEITLS----FKTLQRNGLMLHTGKSADYVNLALKNGA-VSLVINLG 380
+ S + E+T FKT +G+ + D++ + L+ V+ ++G
Sbjct: 798 NTETSYLHFPAFHGELTADVCFFFKTTVSSGVFMENLGITDFIRIELRAPTEVTFSFDVG 857
Query: 381 SGAFEALVEPVNGKFNDNAWHDVKVTRNLR 410
+G E V+ FNDN WH V+ RN++
Sbjct: 858 NGPCEVTVQSPT-PFNDNQWHHVRAERNVK 886
Score = 32.7 bits (73), Expect = 2.8
Identities = 18/56 (32%), Positives = 28/56 (50%), Gaps = 2/56 (3%)
Query: 1333 FQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSEMS 1388
F G L LYYNG+ V +A ++ I ++GNV P T T + +S ++
Sbjct: 329 FHGCLENLYYNGVDVTELAKKHKPQILMMGNVSF--SCPQPQTVPVTFLSSRSYLA 382
Score = 31.6 bits (70), Expect = 6.2
Identities = 23/82 (28%), Positives = 41/82 (50%), Gaps = 3/82 (3%)
Query: 1213 GLGDYLELHIHQG-KIGVKFNVGTDDIAIE-ESNAIINDGKYHVVRFTRSGGNATLQVDS 1270
G+ D++ + + ++ F+VG + +S ND ++H VR R+ A+LQVD
Sbjct: 835 GITDFIRIELRAPTEVTFSFDVGNGPCEVTVQSPTPFNDNQWHHVRAERNVKGASLQVDQ 894
Query: 1271 WPVIERYPAGNNDNERLAIARQ 1292
P + PA + + RL + Q
Sbjct: 895 LPQ-KMQPAPADGHVRLQLNSQ 915
>gi|239743756 PREDICTED: hypothetical protein LOC389722 isoform 2
[Homo sapiens]
Length = 1207
Score = 164 bits (414), Expect = 8e-40
Identities = 191/801 (23%), Positives = 328/801 (40%), Gaps = 114/801 (14%)
Query: 316 IATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHT-GKSADYVNLALKNGAVS 374
+ F G Y L + P++ D I+L FK +Q NG++LH G+ +++ L L G +
Sbjct: 183 VVYFDGQSALLYTLDKKPLKPIRDVISLKFKAMQSNGILLHREGQHGNHITLELIKGKLV 242
Query: 375 LVINLGSGAFEALVEPVN----GKFNDNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTIS 430
+N G+ + + PV +D WH V ++ L V +
Sbjct: 243 FFLNSGNAKLPSTIAPVTLTLGSLLDDQHWHSV---------------LIELLDTQVNFT 287
Query: 431 VDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSP---VSNNFMGCLKEVVYKNND 487
VD T + D + L + GG S PG +F GCL+ + Y D
Sbjct: 288 VDKH-THHFQAKGDSSNLDLNFEISFGGILS----PGRSRAFTRKSFHGCLENLYYNGVD 342
Query: 488 VRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPESFISLPKWNAKKTGSISFD 547
V + LAK+ P++ + G V+F C T+ P+TF + S+++LP + + S++F
Sbjct: 343 V----TELAKKHKPQILMMGNVSFSCPQPQTV-PVTFLSSRSYLALPGNSGEDKVSVTFQ 397
Query: 548 FRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALL 607
FRT G +LF G+ + + F + + DG L L L + +
Sbjct: 398 FRTWNRAGHLLF--GELQRGSGS----------FVLFLKDGKLKLSLFQAGQSPRNVTAG 445
Query: 608 KKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVF 667
+NDG+W+ V F + V+ P + ++D D Y GG N +G
Sbjct: 446 AGLNDGQWHSVSFSAKWSHMNVVVDD--DTAVQPLVAVLIDSGDTYYFGGCLGNSSGSGC 503
Query: 668 PTEVWTALLNYGYVGCIRDLFIDGQSKD--IRQMAEVQSTAGVKPSCSKETAKPCLSNPC 725
+ + G+ GC+R + I ++ D + Q + S ++ T + CL + C
Sbjct: 504 KSPLG------GFQGCLRLITIGDKAVDPILVQQGALGSFRDLQIDSCGITDR-CLPSYC 556
Query: 726 KNNGMCRDGWNRYVCDCSGTGYLGRSCERE-----------------ATVLSYDGSMFMK 768
++ G C W+ + CDC GTGY G +C + DGS +
Sbjct: 557 EHGGECSQSWDTFSCDCLGTGYTGETCHSSLYEQSCEAHKHRGNPSGLYYIDADGSGPLG 616
Query: 769 IQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRD-SADTLRLELDAGRVKLTVNL----- 822
L T++ +R A + A + SA + AG+++ VNL
Sbjct: 617 PFLVYCNMTDSAWTVVRHGGPDAVTLRGAPSGHPLSAVSFAYAAGAGQLRAAVNLAERCE 676
Query: 823 DCIRINCNSSKGPE----TLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGD 878
+ + C +++ P+ T + + NE HT S ++ D Q T + G+
Sbjct: 677 QRLALRCGTARRPDSRDGTPLSWWVGRTNETHT--------SWGGSLPDAQKCTCGLEGN 728
Query: 879 HTRLEFH-NIETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCK-NGDIDY------ 930
+++ N + G + + S + + + L + D + + + DY
Sbjct: 729 CIDSQYYCNCDAG---QNEWTSD--TIVLSQKEHLPVTQIVMTDTGQPHSEADYTLGPLL 783
Query: 931 CELNARFGFRNIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGN 990
C + F + +F T++SY+ + + F FKTT G+ + N G
Sbjct: 784 CRGDKSFW------NSASFNTETSYLHFPAFHGELTADVCFFFKTTVSSGVFMENLGI-T 836
Query: 991 DFIVVEL-VKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDT--SNLHTVKIDT 1047
DFI +EL + + FD+GNG + S P NDNQWH+V R+ ++L ++
Sbjct: 837 DFIRIELRAPTEVTFSFDVGNGPCEVTVQSPTPFNDNQWHHVRAERNVKGASLQVDQLPQ 896
Query: 1048 KITTQITAGARNLDLKSDLYI 1068
K+ G L L S L+I
Sbjct: 897 KMQPAPADGHVRLQLNSQLFI 917
Score = 120 bits (301), Expect = 1e-26
Identities = 115/419 (27%), Positives = 182/419 (43%), Gaps = 21/419 (5%)
Query: 752 CEREATVLSYDGSMFMKIQLPVVMHTEAEDV-SLRFRSQRAYGILMATTSRDSADTLRLE 810
C ++ V+ +DG + L DV SL+F++ ++ GIL+ + + + LE
Sbjct: 177 CAYKSEVVYFDGQSALLYTLDKKPLKPIRDVISLKFKAMQSNGILLHREGQHG-NHITLE 235
Query: 811 LDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQA 870
L G++ +N ++ S+ P TL G L+D WH+V + + TVD +
Sbjct: 236 LIKGKLVFFLNSGNAKLP--STIAPVTLTLGSLLDDQHWHSVLIELLDTQVNFTVD-KHT 292
Query: 871 MTGQMAGDHTRLEFHNIET---GIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGD 927
Q GD + L+ N E GI++ R + +F G L++L +NG+ +L K
Sbjct: 293 HHFQAKGDSSNLDL-NFEISFGGILSPGRSRAFTRKSFHGCLENLYYNGVDVTELAKKHK 351
Query: 928 IDYCEL-NARFGFRNIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNS 986
+ N F PVTF + SY+AL + + FQF+T + G +L+
Sbjct: 352 PQILMMGNVSFSCPQPQTVPVTFLSSRSYLALPGNSGEDKVSVTFQFRTWNRAGHLLFGE 411
Query: 987 GD-GNDFIVVELVKGYLHY-VFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVK 1044
G+ V+ L G L +F G + + LND QWH+V S S+++ V
Sbjct: 412 LQRGSGSFVLFLKDGKLKLSLFQAGQSPRNVTAGAG--LNDGQWHSVSFSAKWSHMNVVV 469
Query: 1045 IDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPD 1104
D + A +D Y GG + S K GFQGCL + + + D
Sbjct: 470 DDDTAVQPLVAVL--IDSGDTYYFGGCLGNSSGSGCK--SPLGGFQGCLRLITIGDKAVD 525
Query: 1105 LI---SDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCN 1160
I AL ++ G + C C + G C Q WD FSCDC T ++G C+
Sbjct: 526 PILVQQGALGSFRDLQIDSCGITDRCLPSYCEHGGECSQSWDTFSCDCLGTGYTGETCH 584
Score = 48.1 bits (113), Expect = 6e-05
Identities = 49/217 (22%), Positives = 86/217 (39%), Gaps = 34/217 (15%)
Query: 54 MSFQLKTRSARGLVLYFD-DEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDG 112
++FQ +T + G +L+ + G F+ + + G+L+LS P + A +NDG
Sbjct: 394 VTFQFRTWNRAGHLLFGELQRGSGSFV--LFLKDGKLKLSLFQAGQSPRNVTAGAGLNDG 451
Query: 113 AWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSG--LFVGGLPPELRAAALKLT 170
WHSV ++ + + +D A V + + SG + GG + K
Sbjct: 452 QWHSVSFSAKWSHMNVVVDDDTAVQPLVA-----VLIDSGDTYYFGGCLGNSSGSGCKSP 506
Query: 171 LASVREREPFKGWIRDVRVNSSQVLPV--------DSGEVKLDDEPPNSGGGSPCEAGEE 222
L F+G +R + + V P+ ++++D C +
Sbjct: 507 LGG------FQGCLRLITIGDKAVDPILVQQGALGSFRDLQIDS----------CGITDR 550
Query: 223 GEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEI 259
C +GG CS D CDC TG+ G+ C +
Sbjct: 551 CLPSYCEHGGECSQSWDTFSCDCLGTGYTGETCHSSL 587
Score = 46.6 bits (109), Expect = 2e-04
Identities = 27/101 (26%), Positives = 48/101 (47%), Gaps = 3/101 (2%)
Query: 37 EGQWTRFPKWNACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIF 96
E + FP ++ +++ F KT + G+ + ++ G DF+ + L + SF +
Sbjct: 799 ETSYLHFPAFHGELTADVCFFFKTTVSSGV--FMENLGITDFIRIELRAPTEVTFSFDVG 856
Query: 97 CAE-PATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAK 136
T+ + TP ND WH VR R + +L +DQ+ K
Sbjct: 857 NGPCEVTVQSPTPFNDNQWHHVRAERNVKGASLQVDQLPQK 897
Score = 39.3 bits (90), Expect = 0.030
Identities = 51/210 (24%), Positives = 85/210 (40%), Gaps = 34/210 (16%)
Query: 206 DEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEIKFGLQC 265
+E S GGS +A + C G + +D Q C+C + + S I +
Sbjct: 705 NETHTSWGGSLPDAQK------CTCGLEGNCIDSQYYCNCDAG--QNEWTSDTIVLSQKE 756
Query: 266 VLPVLLHDNDQGKYCCINTAKPLTEKDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYF 325
LPV + +T +P +E D + L L GD+ +F S F
Sbjct: 757 HLPVT-------QIVMTDTGQPHSEADYTLGPL--LCRGDK-----------SFWNSASF 796
Query: 326 CYDLSQNPIQSSSDEITLS----FKTLQRNGLMLHTGKSADYVNLALKNGA-VSLVINLG 380
+ S + E+T FKT +G+ + D++ + L+ V+ ++G
Sbjct: 797 NTETSYLHFPAFHGELTADVCFFFKTTVSSGVFMENLGITDFIRIELRAPTEVTFSFDVG 856
Query: 381 SGAFEALVEPVNGKFNDNAWHDVKVTRNLR 410
+G E V+ FNDN WH V+ RN++
Sbjct: 857 NGPCEVTVQSPT-PFNDNQWHHVRAERNVK 885
Score = 32.7 bits (73), Expect = 2.8
Identities = 18/56 (32%), Positives = 28/56 (50%), Gaps = 2/56 (3%)
Query: 1333 FQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSEMS 1388
F G L LYYNG+ V +A ++ I ++GNV P T T + +S ++
Sbjct: 329 FHGCLENLYYNGVDVTELAKKHKPQILMMGNVSF--SCPQPQTVPVTFLSSRSYLA 382
Score = 31.6 bits (70), Expect = 6.2
Identities = 23/82 (28%), Positives = 41/82 (50%), Gaps = 3/82 (3%)
Query: 1213 GLGDYLELHIHQG-KIGVKFNVGTDDIAIE-ESNAIINDGKYHVVRFTRSGGNATLQVDS 1270
G+ D++ + + ++ F+VG + +S ND ++H VR R+ A+LQVD
Sbjct: 834 GITDFIRIELRAPTEVTFSFDVGNGPCEVTVQSPTPFNDNQWHHVRAERNVKGASLQVDQ 893
Query: 1271 WPVIERYPAGNNDNERLAIARQ 1292
P + PA + + RL + Q
Sbjct: 894 LPQ-KMQPAPADGHVRLQLNSQ 914
>gi|7662350 cell recognition molecule Caspr2 precursor [Homo sapiens]
Length = 1331
Score = 159 bits (401), Expect = 3e-38
Identities = 159/620 (25%), Positives = 265/620 (42%), Gaps = 122/620 (19%)
Query: 948 TFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGY-LHYVF 1006
+F SSY+ +T Q TS + F FKT + G+ L N G DFI +EL + + F
Sbjct: 802 SFPNPSSYLHFSTFQGETSADISFYFKTLTPWGVFLENMGK-EDFIKLELKSATEVSFSF 860
Query: 1007 DLGNGANLIKGSSNKPLNDNQWHNVMISRDT--SNLHTVKIDTKITTQITAGARNLDLKS 1064
D+GNG I S PLND+QWH V R+ ++L ++ +I T G L+L S
Sbjct: 861 DVGNGPVEIVVRSPTPLNDDQWHRVTAERNVKQASLQVDRLPQQIRKAPTEGHTRLELYS 920
Query: 1065 DLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPS 1124
L++GG ++GF GC+ S+ +NG DL A +G I GC G
Sbjct: 921 QLFVGGAG------------GQQGFLGCIRSLRMNGVTLDLEERAKVTSGFIS-GCSGHC 967
Query: 1125 TTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCN-DPGTTYIFSKGGGQITYKW---- 1179
T+ +C N G CL+++ G+SCDCS T++ G CN D G F + G + Y +
Sbjct: 968 TS-YGTNCENGGKCLERYHGYSCDCSNTAYDGTFCNKDVGA---FFEEGMWLRYNFQAPA 1023
Query: 1180 ---------------PPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIH- 1223
N P + + FST + +L+ + SS D+L + +
Sbjct: 1024 TNARDSSSRVDNAPDQQNSHPDLAQEEIRFSFSTTKAPCILLYI--SSFTTDFLAVLVKP 1081
Query: 1224 QGKIGVKFNVG--TDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGN 1281
G + +++N+G + I+ + + +G+ H V TR L++D +P + + +
Sbjct: 1082 TGSLQIRYNLGGTREPYNIDVDHRNMANGQPHSVNITRHEKTIFLKLDHYPSVSYHLPSS 1141
Query: 1282 NDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQATIIIGGKEQGQPFQGQLSGLY 1341
+D + LG+V++ +D +++ +N+ F G LS +
Sbjct: 1142 SD----TLFNSPKSLFLGKVIETGKID--QEIHKYNTPG------------FTGCLSRVQ 1183
Query: 1342 YNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSEMSTSIMETTTTLATS 1401
+N + L AA N + +V + GE+ ES A
Sbjct: 1184 FNQIAPLK-AALRQTNAS--AHVHIQGEL-----VESNCGA------------------- 1216
Query: 1402 TARRGKPPTKEPISQTTDDILVASAECPSDDEDIDPCEPSSGGLANPTRAGGREPY-PGS 1460
P T P+S TD P + +D A PY PG
Sbjct: 1217 -----SPLTLSPMSSATD---------PWHLDHLD-------------SASADFPYNPGQ 1249
Query: 1461 AEVIRESSSTTGMVV-GIVAAAALCILILLYAMYKYRNRDEGSYHVDESRNYISNSAQSN 1519
+ IR + ++ G++A IL L + +Y R +G+YH +E++ + SA+S
Sbjct: 1250 GQAIRNGVNRNSAIIGGVIAVVIFTILCTLVFLIRYMFRHKGTYHTNEAKG--AESAESA 1307
Query: 1520 GAVVKEKQPSSAKSSNKNKK 1539
A + P+ ++ +++KK
Sbjct: 1308 DAAIMNNDPNFTETIDESKK 1327
Score = 115 bits (289), Expect = 3e-25
Identities = 105/437 (24%), Positives = 197/437 (45%), Gaps = 25/437 (5%)
Query: 741 DCSGTGYLGR-----SCEREATVLSYDGSMFMKIQLP-VVMHTEAEDVSLRFRSQRAYGI 794
D +G G +G C A V+++DG + + + M T + ++L F++ + G+
Sbjct: 165 DWNGEGRIGLRIEVYGCSYWADVINFDGHVVLPYRFRNKKMKTLKDVIALNFKTSESEGV 224
Query: 795 LMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRV 854
++ + D + LEL ++ L++NL ++ G ++ G L+D+ WH+V +
Sbjct: 225 ILHGEGQQG-DYITLELKKAKLVLSLNLGSNQLG--PIYGHTSVMTGSLLDDHHWHSVVI 281
Query: 855 VRRGKSLKLTVD-DQQAMTGQMAGDHTRLEFHNIETGIITERRYLSSVPSNFIGHLQSLT 913
R+G+S+ LT+D Q D+ L++ GI + SS NF G ++S+
Sbjct: 282 ERQGRSINLTLDRSMQHFRTNGEFDYLDLDYEITFGGIPFSGKPSSSSRKNFKGCMESIN 341
Query: 914 FNGMAYIDLCKNGDIDYCEL-NARFGFRNIIADPVTFKTKSSYVALATLQAYTSMHLFFQ 972
+NG+ DL + ++ + N F PV F +SY+ + + FQ
Sbjct: 342 YNGVNITDLARRKKLEPSNVGNLSFSCVEPYTVPVFFNA-TSYLEVPGRLNQDLFSVSFQ 400
Query: 973 FKTTSLDGLILYNS-GDGNDFIVVELVKGYLHYVFDLGNGA-NLIKGSSNKPLNDNQWHN 1030
F+T + +GL++++ D + ++L + + ++ + I SS LND QWH
Sbjct: 401 FRTWNPNGLLVFSHFADNLGNVEIDLTESKVGVHINITQTKMSQIDISSGSGLNDGQWHE 460
Query: 1031 V-MISRDTSNLHTVKIDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGF 1089
V ++++ + T+ D + T + + GG + S ++ + F
Sbjct: 461 VRFLAKENFAILTIDGDEASAVR-TNSPLQVKTGEKYFFGGFLNQMNNSSHSVL--QPSF 517
Query: 1090 QGCLASVDLNGRLPDLISDAL-----FCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDG 1144
QGC+ + ++ +L +L A F N I+ C C + C + G C Q WD
Sbjct: 518 QGCMQLIQVDDQLVNLYEVAQRKPGSFANVSIDM-C-AIIDRCVPNHCEHGGKCSQTWDS 575
Query: 1145 FSCDCSMTSFSGPLCND 1161
F C C T +SG C++
Sbjct: 576 FKCTCDETGYSGATCHN 592
Score = 112 bits (281), Expect = 2e-24
Identities = 103/449 (22%), Positives = 184/449 (40%), Gaps = 57/449 (12%)
Query: 316 IATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLH-TGKSADYVNLALKNGAVS 374
+ F G Y +++ D I L+FKT + G++LH G+ DY+ L LK +
Sbjct: 187 VINFDGHVVLPYRFRNKKMKTLKDVIALNFKTSESEGVILHGEGQQGDYITLELKKAKLV 246
Query: 375 LVINLGS---GAFEALVEPVNGKF-NDNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTIS 430
L +NLGS G + G +D+ WH V + R R S+ ++
Sbjct: 247 LSLNLGSNQLGPIYGHTSVMTGSLLDDHHWHSVVIERQGR---------------SINLT 291
Query: 431 VDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRL 490
+D + T ++ L D GG P + P S NF GC++ + Y +
Sbjct: 292 LDRSMQHFR-TNGEFDYLDLDYEITFGGIPFSGK-PSSSSRKNFKGCMESINYNG----V 345
Query: 491 ELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPESFISLPKWNAKKTGSISFDFRT 550
++ LA++ + G ++F C T+ P+ F S++ +P + S+SF FRT
Sbjct: 346 NITDLARRKKLEPSNVGNLSFSCVEPYTV-PVFFNAT-SYLEVPGRLNQDLFSVSFQFRT 403
Query: 551 TEPNGLILFSHGKPR------HQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIK 604
PNGL++FSH ++K I + + +D + GSG
Sbjct: 404 WNPNGLLVFSHFADNLGNVEIDLTESKVGVHINITQTKMSQID------ISSGSG----- 452
Query: 605 ALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAG 664
+NDG+W+ V F ++++ + ++ + GG
Sbjct: 453 -----LNDGQWHEVRFLAKENFAILTIDGDEASAVRTNSPLQVKTGEKYFFGGFLNQMNN 507
Query: 665 LVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSK-ETAKPCLSN 723
++L + GC++ + +D Q ++ ++A+ + + S C+ N
Sbjct: 508 SSH------SVLQPSFQGCMQLIQVDDQLVNLYEVAQRKPGSFANVSIDMCAIIDRCVPN 561
Query: 724 PCKNNGMCRDGWNRYVCDCSGTGYLGRSC 752
C++ G C W+ + C C TGY G +C
Sbjct: 562 HCEHGGKCSQTWDSFKCTCDETGYSGATC 590
Score = 97.1 bits (240), Expect = 1e-19
Identities = 112/465 (24%), Positives = 193/465 (41%), Gaps = 73/465 (15%)
Query: 523 TFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFA 582
+F P S++ + + + ISF F+T P G+ L + GK DF
Sbjct: 802 SFPNPSSYLHFSTFQGETSADISFYFKTLTPWGVFLENMGKE--------------DFIK 847
Query: 583 IEMLDG-HLYLLLDMGSGTIKIKALLKK-VNDGEWYHVDFQRDGRSGTISVNTLRTPYT- 639
+E+ + D+G+G ++I +ND +W+ V +R+ + ++ V+ L
Sbjct: 848 LELKSATEVSFSFDVGNGPVEIVVRSPTPLNDDQWHRVTAERNVKQASLQVDRLPQQIRK 907
Query: 640 APGESEI-LDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQ 698
AP E L+L +L++GG + G++GCIR L ++G + D+ +
Sbjct: 908 APTEGHTRLELYSQLFVGGAGGQQ----------------GFLGCIRSLRMNGVTLDLEE 951
Query: 699 MAEVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATV 758
A+V T+G CS C+N G C + ++ Y CDCS T Y G C ++
Sbjct: 952 RAKV--TSGFISGCSGHCTS--YGTNCENGGKCLERYHGYSCDCSNTAYDGTFCNKDVGA 1007
Query: 759 LSYDGS-MFMKIQLPVVMHTEAEDVSLRFRS----QRAYGILMATTSRDSADTLR----- 808
+G + Q P T A D S R + Q ++ L R S T +
Sbjct: 1008 FFEEGMWLRYNFQAPA---TNARDSSSRVDNAPDQQNSHPDLAQEEIRFSFSTTKAPCIL 1064
Query: 809 -------LELDAGRVKLTVNLDCIRINCNSSKGPETLFAGY-NLNDNEWHTVRVVRRGKS 860
+ A VK T +L IR N ++ P + + N+ + + H+V + R K+
Sbjct: 1065 LYISSFTTDFLAVLVKPTGSLQ-IRYNLGGTREPYNIDVDHRNMANGQPHSVNITRHEKT 1123
Query: 861 LKLTVDDQQAMTGQMAGDHTRLEFHN---------IETGIITERRYLSSVPSNFIGHLQS 911
+ L +D +++ + L F++ IETG I + + + P F G L
Sbjct: 1124 IFLKLDHYPSVSYHLPSSSDTL-FNSPKSLFLGKVIETGKIDQEIHKYNTP-GFTGCLSR 1181
Query: 912 LTFNGMAYID--LCKNGDIDYCELNARFGFRNIIADPVTFKTKSS 954
+ FN +A + L + + + N A P+T SS
Sbjct: 1182 VQFNQIAPLKAALRQTNASAHVHIQGELVESNCGASPLTLSPMSS 1226
Score = 73.9 bits (180), Expect = 1e-12
Identities = 72/337 (21%), Positives = 136/337 (40%), Gaps = 79/337 (23%)
Query: 544 ISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSG---- 599
I+ +F+T+E G+IL G+ + D+ +E+ L L L++GS
Sbjct: 212 IALNFKTSESEGVILHGEGQ-------------QGDYITLELKKAKLVLSLNLGSNQLGP 258
Query: 600 -----TIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELY 654
++ +LL +D W+ V +R GRS ++++ + GE + LDLD E+
Sbjct: 259 IYGHTSVMTGSLL---DDHHWHSVVIERQGRSINLTLDRSMQHFRTNGEFDYLDLDYEIT 315
Query: 655 LGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSK 714
GG+P +G S S+
Sbjct: 316 FGGIP---------------------------------------------FSGKPSSSSR 330
Query: 715 ETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATV-LSYDGSMFMKIQLPV 773
+ K C+ + N D R + S G L SC TV + ++ + ++++ P
Sbjct: 331 KNFKGCMESINYNGVNITDLARRKKLEPSNVGNLSFSCVEPYTVPVFFNATSYLEV--PG 388
Query: 774 VMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSK 833
++ + VS +FR+ G+L+ + D+ + ++L +V + +N+ +
Sbjct: 389 RLNQDLFSVSFQFRTWNPNGLLVFSHFADNLGNVEIDLTESKVGVHINI------TQTKM 442
Query: 834 GPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQA 870
+ +G LND +WH VR + + LT+D +A
Sbjct: 443 SQIDISSGSGLNDGQWHEVRFLAKENFAILTIDGDEA 479
Score = 62.0 bits (149), Expect = 4e-09
Identities = 54/222 (24%), Positives = 95/222 (42%), Gaps = 27/222 (12%)
Query: 40 WTRFPKWNACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAE 99
+ F + +++SF KT + G+ L ++ G DF++L L + SF +
Sbjct: 809 YLHFSTFQGETSADISFYFKTLTPWGVFL--ENMGKEDFIKLELKSATEVSFSFDVGNGP 866
Query: 100 PATLL-ADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSK-RRDMTVFSGLFVGG 157
++ + TP+ND WH V R + +L +D++ + + ++ + ++S LFVGG
Sbjct: 867 VEIVVRSPTPLNDDQWHRVTAERNVKQASLQVDRLPQQIRKAPTEGHTRLELYSQLFVGG 926
Query: 158 LPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPC 217
++ F G IR +R+N + + +V SG S C
Sbjct: 927 ----------------AGGQQGFLGCIRSLRMNGVTLDLEERAKV-------TSGFISGC 963
Query: 218 EAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEI 259
G C NGG C CDCS T + G C++++
Sbjct: 964 SGHCTSYGTNCENGGKCLERYHGYSCDCSNTAYDGTFCNKDV 1005
Score = 61.6 bits (148), Expect = 6e-09
Identities = 77/306 (25%), Positives = 134/306 (43%), Gaps = 55/306 (17%)
Query: 973 FKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLG-NGANLIKGSSN----KPLNDNQ 1027
FKT+ +G+IL+ G D+I +EL K L +LG N I G ++ L+D+
Sbjct: 216 FKTSESEGVILHGEGQQGDYITLELKKAKLVLSLNLGSNQLGPIYGHTSVMTGSLLDDHH 275
Query: 1028 WHNVMISRDTSNLHTVKIDTKITTQITAGARN-LDLKSDLYIGGVAKETYKSLPKLVHAK 1086
WH+V+I R +++ + +D + T G + LDL ++ GG+ + P ++
Sbjct: 276 WHSVVIERQGRSIN-LTLDRSMQHFRTNGEFDYLDLDYEITFGGIP---FSGKPSS-SSR 330
Query: 1087 EGFQGCLASVDLNG-RLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGF 1145
+ F+GC+ S++ NG + DL ++ SN G
Sbjct: 331 KNFKGCMESINYNGVNITDLARR-------------------KKLEPSNVG--------- 362
Query: 1146 SCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVL 1205
SFS C +P T +F +Y P R + ++ F T +L
Sbjct: 363 -----NLSFS---CVEPYTVPVFFNA---TSYLEVPG-RLNQDLFSVSFQFRTWNPNGLL 410
Query: 1206 VRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEE--SNAIINDGKYHVVRFTRSGGN 1263
V + LG+ +E+ + + K+GV N+ ++ + S + +NDG++H VRF
Sbjct: 411 VFSHFADNLGN-VEIDLTESKVGVHINITQTKMSQIDISSGSGLNDGQWHEVRFLAKENF 469
Query: 1264 ATLQVD 1269
A L +D
Sbjct: 470 AILTID 475
Score = 49.3 bits (116), Expect = 3e-05
Identities = 47/163 (28%), Positives = 76/163 (46%), Gaps = 29/163 (17%)
Query: 337 SSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGA-VSLVINLGSGAFEALVEPVNGKF 395
+S +I+ FKTL G+ L D++ L LK+ VS ++G+G E +V
Sbjct: 819 TSADISFYFKTLTPWGVFLENMGKEDFIKLELKSATEVSFSFDVGNGPVEIVVRSPT-PL 877
Query: 396 NDNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTISVDGILTTTGYTQ-EDYTMLGSDDFF 454
ND+ WH V RN++Q S V++L + + T G+T+ E Y+ L
Sbjct: 878 NDDQWHRVTAERNVKQAS----LQVDRLPQQIRKA-----PTEGHTRLELYSQL------ 922
Query: 455 YVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAK 497
+VGG+ F+GC++ + + N V L+L AK
Sbjct: 923 FVGGAGG---------QQGFLGCIRSL--RMNGVTLDLEERAK 954
Score = 45.1 bits (105), Expect = 5e-04
Identities = 49/210 (23%), Positives = 83/210 (39%), Gaps = 16/210 (7%)
Query: 54 MSFQLKTRSARGLVLYFDDEGFCDFLELILTRGG-RLQLSFSIFCAEPATLLADTPVNDG 112
+SFQ +T + GL+++ +E+ LT + ++ + + + + +NDG
Sbjct: 397 VSFQFRTWNPNGLLVFSHFADNLGNVEIDLTESKVGVHINITQTKMSQIDISSGSGLNDG 456
Query: 113 AWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLA 172
WH VR + L ID EA V S + T F GG ++ ++ +
Sbjct: 457 QWHEVRFLAKENFAILTIDGDEASAVRTNSPLQVKTG-EKYFFGGFLNQMNNSSHSVLQP 515
Query: 173 SVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGG---SPCEAGEEGEGGVCL 229
S F+G ++ ++V+ V + + K P S C + C
Sbjct: 516 S------FQGCMQLIQVDDQLVNLYEVAQRK-----PGSFANVSIDMCAIIDRCVPNHCE 564
Query: 230 NGGVCSVVDDQAVCDCSRTGFRGKDCSQEI 259
+GG CS D C C TG+ G C I
Sbjct: 565 HGGKCSQTWDSFKCTCDETGYSGATCHNSI 594
Score = 40.8 bits (94), Expect = 0.010
Identities = 43/210 (20%), Positives = 82/210 (39%), Gaps = 38/210 (18%)
Query: 1182 NDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIA-- 1239
N + T D +A+ F T + E V++ + G DY+ L + + K+ + N+G++ +
Sbjct: 202 NKKMKTLKDVIALNFKTSESEGVILHGEGQQG--DYITLELKKAKLVLSLNLGSNQLGPI 259
Query: 1240 ----IEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNERLAIARQRIP 1295
+ ++++D +H V R G + L +D R
Sbjct: 260 YGHTSVMTGSLLDDHHWHSVVIERQGRSINLTLD---------------------RSMQH 298
Query: 1296 YRLGRVVDEWLLDKGRQLTIFNSQATIIIGGKEQGQP---FQGQLSGLYYNGLKVLNMAA 1352
+R D LD ++T I GK F+G + + YNG+ + ++A
Sbjct: 299 FRTNGEFD--YLDLDYEITF----GGIPFSGKPSSSSRKNFKGCMESINYNGVNITDLAR 352
Query: 1353 ENDANIAIVGNVRLVGEVPSSMTTESTATA 1382
+ VGN+ P ++ AT+
Sbjct: 353 RKKLEPSNVGNLSFSCVEPYTVPVFFNATS 382
>gi|54873613 agrin [Homo sapiens]
Length = 2045
Score = 134 bits (336), Expect = 9e-31
Identities = 183/722 (25%), Positives = 292/722 (40%), Gaps = 116/722 (16%)
Query: 22 GCWAELGSGLEFPGAEGQ-WTRFPKWNACCESEMSFQLKTRSARGLVLYFDDEGFCDFLE 80
G E G P EG+ + FP A ++ + + +GL+LY + DFL
Sbjct: 1363 GAVCEKVLGAPVPAFEGRSFLAFPTLRAYHTLRLALEFRALEPQGLLLYNGNARGKDFLA 1422
Query: 81 LILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEV 140
L L GR+QL F PA L + PV G WH + + R +R TL +D E
Sbjct: 1423 LALL-DGRVQLRFDTGSG-PAVLTSAVPVEPGQWHRLELSRHWRRGTLSVDGETPVLGES 1480
Query: 141 KSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQV------ 194
S + + + LFVGG+P + A AL+ T +G IR + VN+ ++
Sbjct: 1481 PSGTDGLNLDTDLFVGGVPEDQAAVALERTFVGA----GLRGCIRLLDVNNQRLELGIGP 1536
Query: 195 --LPVDSGEVKLDDEP--PN-SGGGSPCEAGEEGEGGV-CLNGGVCSVVDDQAVCDCSRT 248
SG + D P PN GG+PC+ E G C G V D+ C
Sbjct: 1537 GAATRGSGVGECGDHPCLPNPCHGGAPCQNLEAGRFHCQCPPGRVGPTCADEK-SPCQPN 1595
Query: 249 GFRG-KDCSQEIKFGLQCVLPVLLHDNDQGKYCCINTAKPLTEKDNNVEGLAHLMMGDQG 307
G C + G QC P+ +G +C + + +G + G
Sbjct: 1596 PCHGAAPCRVLPEGGAQCECPL----GREGTFC---------QTASGQDGSGPFLADFNG 1642
Query: 308 KSKGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGK----SADY 363
S +G F DL + + + F +GL+L+ G+ D+
Sbjct: 1643 FSH------LELRGLHTFARDLGEKM------ALEVVFLARGPSGLLLYNGQKTDGKGDF 1690
Query: 364 VNLALKNGAVSLVINLGSGAFEALV---EPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMV 420
V+LAL++ + +LG GA A++ EPV AW V + RN R+ +
Sbjct: 1691 VSLALRDRRLEFRYDLGKGA--AVIRSREPV----TLGAWTRVSLERNGRKGA------- 1737
Query: 421 NKLHCSVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLP-GSPVSNNFMGCLK 479
+ V G + +T+L + YVGG+P + L + VS+ F G ++
Sbjct: 1738 --------LRVGDGPRVLGESPVPHTVLNLKEPLYVGGAPDFSKLARAAAVSSGFDGAIQ 1789
Query: 480 EV------VYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVAT----------LDPIT 523
V + V ++ + G P + G C N A+ L P
Sbjct: 1790 LVSLGGRQLLTPEHVLRQVDVTSFAGHPCTRASG---HPCLNGASCVPREAAYVCLCPGG 1846
Query: 524 FETPESFISLPKWNAKKTGSISFDFRT--------TEPNGLILFSHGKPRHQKDAKHPQM 575
F P L + +A +++FD RT TE + +H + + +A +
Sbjct: 1847 FSGPHCEKGLVEKSAGDVDTLAFDGRTFVEYLNAVTESEKALQSNHFELSLRTEATQGLV 1906
Query: 576 I-------KVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGT 628
+ + D+ A+ ++DGHL L ++GS + +++ + VN W V R+ R G+
Sbjct: 1907 LWSGKATERADYVALAIVDGHLQLSYNLGSQPVVLRSTV-PVNTNRWLRVVAHREQREGS 1965
Query: 629 ISV-NTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDL 687
+ V N ++P + LD D L+LGGLPE G P T G+VGC+RD+
Sbjct: 1966 LQVGNEAPVTGSSPLGATQLDTDGALWLGGLPELPVGPALPKAYGT-----GFVGCLRDV 2020
Query: 688 FI 689
+
Sbjct: 2021 VV 2022
Score = 117 bits (292), Expect = 1e-25
Identities = 170/711 (23%), Positives = 283/711 (39%), Gaps = 155/711 (21%)
Query: 513 CENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKH 572
CE V FE SF++ P A T ++ +FR EP GL+L++ G R +
Sbjct: 1366 CEKVLGAPVPAFEG-RSFLAFPTLRAYHTLRLALEFRALEPQGLLLYN-GNARGK----- 1418
Query: 573 PQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVN 632
DF A+ +LDG + L D GSG + + + V G+W+ ++ R R GT+SV+
Sbjct: 1419 ------DFLALALLDGRVQLRFDTGSGPAVLTSAVP-VEPGQWHRLELSRHWRRGTLSVD 1471
Query: 633 TLRTPYT--APGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFID 690
TP +P ++ L+LD +L++GG+PE++A + + G GCIR L ++
Sbjct: 1472 G-ETPVLGESPSGTDGLNLDTDLFVGGVPEDQAAVALER----TFVGAGLRGCIRLLDVN 1526
Query: 691 GQSKDIRQMAEVQSTAG--------------------------------------VKPSC 712
Q ++ + +T G V P+C
Sbjct: 1527 NQRLELG-IGPGAATRGSGVGECGDHPCLPNPCHGGAPCQNLEAGRFHCQCPPGRVGPTC 1585
Query: 713 SKETAKPCLSNPCKNNGMCR---DGWNRYVCDCSGTGYLGRSCEREATVLSYDGS----- 764
+ E + PC NPC CR +G + C+C LGR T DGS
Sbjct: 1586 ADEKS-PCQPNPCHGAAPCRVLPEGGAQ--CECP----LGREGTFCQTASGQDGSGPFLA 1638
Query: 765 ---MFMKIQLPVVMHTEAEDVSLR------FRSQRAYGILMATTSR--DSADTLRLELDA 813
F ++L +HT A D+ + F ++ G+L+ + D + L L
Sbjct: 1639 DFNGFSHLELR-GLHTFARDLGEKMALEVVFLARGPSGLLLYNGQKTDGKGDFVSLALRD 1697
Query: 814 GRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTG 873
R++ +L KG + + + W V + R G+ L V D + G
Sbjct: 1698 RRLEFRYDL---------GKGAAVIRSREPVTLGAWTRVSLERNGRKGALRVGDGPRVLG 1748
Query: 874 QMAGDHTRLEFHN-IETGIITERRYL---SSVPSNFIGHLQSLTFNG------------- 916
+ HT L + G + L ++V S F G +Q ++ G
Sbjct: 1749 ESPVPHTVLNLKEPLYVGGAPDFSKLARAAAVSSGFDGAIQLVSLGGRQLLTPEHVLRQV 1808
Query: 917 ----------------------------MAYIDLCKNG-DIDYCE---LNARFGFRNIIA 944
AY+ LC G +CE + G + +A
Sbjct: 1809 DVTSFAGHPCTRASGHPCLNGASCVPREAAYVCLCPGGFSGPHCEKGLVEKSAGDVDTLA 1868
Query: 945 -DPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYN--SGDGNDFIVVELVKGY 1001
D TF + V + +A S H +T + GL+L++ + + D++ + +V G+
Sbjct: 1869 FDGRTFVEYLNAVT-ESEKALQSNHFELSLRTEATQGLVLWSGKATERADYVALAIVDGH 1927
Query: 1002 LHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRD-TSNLHTVKIDTKITTQITAGARNL 1060
L ++LG+ +++ S P+N N+W V+ R+ V + +T GA L
Sbjct: 1928 LQLSYNLGSQPVVLR--STVPVNTNRWLRVVAHREQREGSLQVGNEAPVTGSSPLGATQL 1985
Query: 1061 DLKSDLYIGGVAK-ETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDAL 1110
D L++GG+ + +LPK GF GCL V + L+ DA+
Sbjct: 1986 DTDGALWLGGLPELPVGPALPKAYGT--GFVGCLRDVVVGRHPLHLLEDAV 2034
Score = 84.0 bits (206), Expect = 1e-15
Identities = 86/386 (22%), Positives = 157/386 (40%), Gaps = 65/386 (16%)
Query: 942 IIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYN-SGDGNDFIVVELVKG 1000
++ PV S++A TL+AY ++ L +F+ GL+LYN + G DF+ + L+ G
Sbjct: 1369 VLGAPVPAFEGRSFLAFPTLRAYHTLRLALEFRALEPQGLLLYNGNARGKDFLALALLDG 1428
Query: 1001 YLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKID--TKITTQITAGAR 1058
+ FD G+G ++ +S P+ QWH + +SR T+ +D T + + +G
Sbjct: 1429 RVQLRFDTGSGPAVL--TSAVPVEPGQWHRLELSRHWRR-GTLSVDGETPVLGESPSGTD 1485
Query: 1059 NLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGR----------------- 1101
L+L +DL++GGV ++ + G +GC+ +D+N +
Sbjct: 1486 GLNLDTDLFVGGVPEDQAAVALERTFVGAGLRGCIRLLDVNNQRLELGIGPGAATRGSGV 1545
Query: 1102 --------LPDLISDALFCN-------------GQIERGCEGPSTTCQEDSCSNQGVC-L 1139
LP+ C G++ C + CQ + C C +
Sbjct: 1546 GECGDHPCLPNPCHGGAPCQNLEAGRFHCQCPPGRVGPTCADEKSPCQPNPCHGAAPCRV 1605
Query: 1140 QQWDGFSCDC------------SMTSFSGPLCND-PGTTYIFSKGGGQITYKWPPNDRPS 1186
G C+C S SGP D G +++ + G T+ ++ +
Sbjct: 1606 LPEGGAQCECPLGREGTFCQTASGQDGSGPFLADFNGFSHLELR--GLHTFARDLGEKMA 1663
Query: 1187 TRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAI 1246
LA G S + +L + G GD++ L + ++ ++++G A+ S
Sbjct: 1664 LEVVFLARGPSGL----LLYNGQKTDGKGDFVSLALRDRRLEFRYDLG-KGAAVIRSREP 1718
Query: 1247 INDGKYHVVRFTRSGGNATLQVDSWP 1272
+ G + V R+G L+V P
Sbjct: 1719 VTLGAWTRVSLERNGRKGALRVGDGP 1744
Score = 64.7 bits (156), Expect = 7e-10
Identities = 75/331 (22%), Positives = 126/331 (38%), Gaps = 28/331 (8%)
Query: 967 MHLFFQFKTTSLDGLILYNSG--DGN-DFIVVELVKGYLHYVFDLGNGANLIKGSSNKPL 1023
M L F GL+LYN DG DF+ + L L + +DLG GA +I+ S +P+
Sbjct: 1662 MALEVVFLARGPSGLLLYNGQKTDGKGDFVSLALRDRRLEFRYDLGKGAAVIR--SREPV 1719
Query: 1024 NDNQWHNVMISRD-TSNLHTVKIDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLPKL 1082
W V + R+ V ++ + L+LK LY+GG + L +
Sbjct: 1720 TLGAWTRVSLERNGRKGALRVGDGPRVLGESPVPHTVLNLKEPLYVGGA--PDFSKLARA 1777
Query: 1083 VHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQW 1142
GF G + V L GR L + + + P T C N C+ +
Sbjct: 1778 AAVSSGFDGAIQLVSLGGR-QLLTPEHVLRQVDVTSFAGHPCTRASGHPCLNGASCVPRE 1836
Query: 1143 DGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQIT------------YKWPPNDRPSTRAD 1190
+ C C FSGP C + K G + + +++
Sbjct: 1837 AAYVCLCP-GGFSGPHCEKG----LVEKSAGDVDTLAFDGRTFVEYLNAVTESEKALQSN 1891
Query: 1191 RLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDG 1250
+ T + +++ ++ DY+ L I G + + +N+G+ + + S +N
Sbjct: 1892 HFELSLRTEATQGLVLWSGKATERADYVALAIVDGHLQLSYNLGSQPVVL-RSTVPVNTN 1950
Query: 1251 KYHVVRFTRSGGNATLQV-DSWPVIERYPAG 1280
++ V R +LQV + PV P G
Sbjct: 1951 RWLRVVAHREQREGSLQVGNEAPVTGSSPLG 1981
Score = 63.5 bits (153), Expect = 1e-09
Identities = 52/207 (25%), Positives = 89/207 (42%), Gaps = 19/207 (9%)
Query: 707 GVKPSCSKETAKPCLSNPCKNNGMCRDGW---NRYVCDCSGTGYLGRSCER--EATVLSY 761
G +P ++ KPC S PC + G C+D W + C C G G CE+ A V ++
Sbjct: 1320 GRRPPAPQQPPKPCDSQPCFHGGTCQD-WALGGGFTCSCP-AGRGGAVCEKVLGAPVPAF 1377
Query: 762 DGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVN 821
+G F+ HT ++L FR+ G+L+ + D L L L GRV+L
Sbjct: 1378 EGRSFLAFPTLRAYHTLR--LALEFRALEPQGLLLYNGNARGKDFLALALLDGRVQL--- 1432
Query: 822 LDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTR 881
++ GP L + + +WH + + R + L+VD + + G+
Sbjct: 1433 ------RFDTGSGPAVLTSAVPVEPGQWHRLELSRHWRRGTLSVDGETPVLGESPSGTDG 1486
Query: 882 LEFH-NIETGIITERRYLSSVPSNFIG 907
L ++ G + E + ++ F+G
Sbjct: 1487 LNLDTDLFVGGVPEDQAAVALERTFVG 1513
>gi|116284404 cell recognition protein CASPR4 isoform 1 [Homo
sapiens]
Length = 1308
Score = 132 bits (332), Expect = 3e-30
Identities = 114/461 (24%), Positives = 196/461 (42%), Gaps = 82/461 (17%)
Query: 316 IATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHT-GKSADYVNLALKNGAVS 374
+ G Y Q + D I+L FKT+Q +G++LH G + D++ L L+ +
Sbjct: 183 VVDLDGKSSLLYRFDQKSLSPIKDIISLKFKTMQSDGILLHREGPNGDHITLQLRRARLF 242
Query: 375 LVINLGSGAFEALVEPVN----GKFNDNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTIS 430
L+IN G + VN +D WH V ++ +L V +
Sbjct: 243 LLINSGEAKLPSTSTLVNLTLGSLLDDQHWHSV---------------LIQRLGKQVNFT 287
Query: 431 VDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVS---NNFMGCLKEVVYKNND 487
VD + + ++ ++ D GG P+ PG VS NF GCL+ + Y D
Sbjct: 288 VDEHRHHF-HARGEFNLMNLDYEISFGGIPA----PGKSVSFPHRNFHGCLENLYYNGVD 342
Query: 488 VRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPESFISLPKWNAKKTGSISFD 547
+ LAKQ P++ G V+F C ++ P+TF + S+++LP ++ ++ S +F
Sbjct: 343 I----IDLAKQQKPQIIAMGNVSFSCSQPQSM-PVTFLSSRSYLALPDFSGEEEVSATFQ 397
Query: 548 FRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALL 607
FRT GL+LFS ++++ G + L L G K+K+ L
Sbjct: 398 FRTWNKAGLLLFSE---------------------LQLISGGILLFLSDG----KLKSNL 432
Query: 608 KK-------------VNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELY 654
+ +NDG+W+ V +++V+ E + Y
Sbjct: 433 YQPGKLPSDITAGVELNDGQWHSVSLSAKKNHLSVAVDGQMASAAPLLGPEQIYSGGTYY 492
Query: 655 LGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIR--QMAEVQSTAGVK-PS 711
GG P+ G + + G+ GC+R + I G+ D+ Q + + + ++ S
Sbjct: 493 FGGCPDKSFGSKCKSPLG------GFQGCMRLISISGKVVDLISVQQGSLGNFSDLQIDS 546
Query: 712 CSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSC 752
C + CL N C++ G C W+ + C+C+ TGY G +C
Sbjct: 547 CG--ISDRCLPNYCEHGGECSQSWSTFHCNCTNTGYRGATC 585
Score = 131 bits (330), Expect = 4e-30
Identities = 125/463 (26%), Positives = 206/463 (44%), Gaps = 61/463 (13%)
Query: 752 CEREATVLSYDGSMFMKIQLPVVMHTEAEDV-SLRFRSQRAYGILMATTSRDSADTLRLE 810
C + V+ DG + + + +D+ SL+F++ ++ GIL+ + D + L+
Sbjct: 177 CAYRSEVVDLDGKSSLLYRFDQKSLSPIKDIISLKFKTMQSDGILLHREG-PNGDHITLQ 235
Query: 811 LDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQA 870
L R+ L +N ++ S+ TL G L+D WH+V + R GK + TVD+ +
Sbjct: 236 LRRARLFLLINSGEAKLPSTSTLVNLTL--GSLLDDQHWHSVLIQRLGKQVNFTVDEHRH 293
Query: 871 MTGQMAGDHTRLEFHNIET-------GIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLC 923
H R EF+ + GI + +S NF G L++L +NG+ IDL
Sbjct: 294 HF------HARGEFNLMNLDYEISFGGIPAPGKSVSFPHRNFHGCLENLYYNGVDIIDLA 347
Query: 924 KNGDIDYCEL-NARFGFRNIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLI 982
K + N F + PVTF + SY+AL + FQF+T + GL+
Sbjct: 348 KQQKPQIIAMGNVSFSCSQPQSMPVTFLSSRSYLALPDFSGEEEVSATFQFRTWNKAGLL 407
Query: 983 LYNSGDGNDFIVVELVKG-YLHYVFDLGNGANLIKG-------SSNKPLNDNQWHNVMIS 1034
L++ ++L+ G L ++ D +NL + ++ LND QWH+V +S
Sbjct: 408 LFSE--------LQLISGGILLFLSDGKLKSNLYQPGKLPSDITAGVELNDGQWHSVSLS 459
Query: 1035 RDTSNLHTVKIDTKITTQITA-GARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCL 1093
++L +V +D ++ + G + Y GG +++ S K GFQGC+
Sbjct: 460 AKKNHL-SVAVDGQMASAAPLLGPEQIYSGGTYYFGGCPDKSFGS--KCKSPLGGFQGCM 516
Query: 1094 ASVDLNGRLPDLISDAL-----FCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCD 1148
+ ++G++ DLIS F + QI+ C G S C + C + G C Q W F C+
Sbjct: 517 RLISISGKVVDLISVQQGSLGNFSDLQID-SC-GISDRCLPNYCEHGGECSQSWSTFHCN 574
Query: 1149 CSMTSFSGPLC----------------NDPGTTYIFSKGGGQI 1175
C+ T + G C N G YI S G G +
Sbjct: 575 CTNTGYRGATCHNSIYEQSCEAYKHRGNTSGFYYIDSDGSGPL 617
Score = 114 bits (286), Expect = 6e-25
Identities = 95/343 (27%), Positives = 155/343 (45%), Gaps = 39/343 (11%)
Query: 948 TFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKG-YLHYVF 1006
+F T++SY+ T S + F FKTT+ G+ L N G DFI +EL + + F
Sbjct: 796 SFDTEASYLHFPTFHGELSADVSFFFKTTASSGVFLENLGIA-DFIRIELRSPTVVTFSF 854
Query: 1007 DLGNGANLIKGSSNKPLNDNQWHNVMISRDT--SNLHTVKIDTKITTQITAGARNLDLKS 1064
D+GNG I S NDNQWH+V + R+ ++L ++ K G L L S
Sbjct: 855 DVGNGPFEISVQSPTHFNDNQWHHVRVERNMKEASLQVDQLTPKTQPAPADGHVLLQLNS 914
Query: 1065 DLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPS 1124
L++GG A + GF GC+ S+ LNG DL A +++ GC G
Sbjct: 915 QLFVGGTATR-----------QRGFLGCIRSLQLNGMTLDLEERAQV-TPEVQPGCRGHC 962
Query: 1125 TTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDR 1184
++ + C N G C ++ GF CDC+ ++++GP C++ + Y S G + Y + N
Sbjct: 963 SSYGK-LCRNGGKCRERPIGFFCDCTFSAYTGPFCSNEISAYFGS--GSSVIYNFQENYL 1019
Query: 1185 PSTRA---------------DRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQG---K 1226
S + + + F T + ++L+ V SS +YL + I + +
Sbjct: 1020 LSKNSSSHAASFHGDMKLSREMIKFSFRTTRTPSLLLFV--SSFYKEYLSVIIAKNGSLQ 1077
Query: 1227 IGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVD 1269
I K N + + + DG+ H + R G +++D
Sbjct: 1078 IRYKLNKYQEPDVVNFDFKNMADGQLHHIMINREEGVVFIEID 1120
Score = 97.4 bits (241), Expect = 9e-20
Identities = 90/394 (22%), Positives = 165/394 (41%), Gaps = 69/394 (17%)
Query: 504 KIHGVVAFK-----CENVATL-DPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLI 557
++H A+K C+ + + +F+T S++ P ++ + + +SF F+TT +G+
Sbjct: 771 RLHSEAAYKLGPLLCQGDRSFWNSASFDTEASYLHFPTFHGELSADVSFFFKTTASSGVF 830
Query: 558 LFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLL-LDMGSGTIKIKALLKK-VNDGEW 615
L + G DF IE+ + D+G+G +I ND +W
Sbjct: 831 LENLGI--------------ADFIRIELRSPTVVTFSFDVGNGPFEISVQSPTHFNDNQW 876
Query: 616 YHVDFQRDGRSGTISVNTLRTPYTAPGESE---ILDLDDELYLGGLPENKAGLVFPTEVW 672
+HV +R+ + ++ V+ L TP T P ++ +L L+ +L++GG
Sbjct: 877 HHVRVERNMKEASLQVDQL-TPKTQPAPADGHVLLQLNSQLFVGG--------------- 920
Query: 673 TALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPCLSNPCKNNGMCR 732
TA G++GCIR L ++G + D+ + A+V T V+P C + C+N G CR
Sbjct: 921 TATRQRGFLGCIRSLQLNGMTLDLEERAQV--TPEVQPGCRGHCSS--YGKLCRNGGKCR 976
Query: 733 DGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFM----------------KIQLPVVMH 776
+ + CDC+ + Y G C E + GS + M
Sbjct: 977 ERPIGFFCDCTFSAYTGPFCSNEISAYFGSGSSVIYNFQENYLLSKNSSSHAASFHGDMK 1036
Query: 777 TEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPE 836
E + FR+ R +L+ +S + G ++ IR N + P+
Sbjct: 1037 LSREMIKFSFRTTRTPSLLLFVSSFYKEYLSVIIAKNGSLQ-------IRYKLNKYQEPD 1089
Query: 837 TL-FAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQ 869
+ F N+ D + H + + R + + +DD +
Sbjct: 1090 VVNFDFKNMADGQLHHIMINREEGVVFIEIDDNR 1123
Score = 68.6 bits (166), Expect = 5e-11
Identities = 56/225 (24%), Positives = 93/225 (41%), Gaps = 26/225 (11%)
Query: 37 EGQWTRFPKWNACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIF 96
E + FP ++ +++SF KT ++ G+ L ++ G DF+ + L + SF +
Sbjct: 800 EASYLHFPTFHGELSADVSFFFKTTASSGVFL--ENLGIADFIRIELRSPTVVTFSFDVG 857
Query: 97 CAE-PATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVF-SGLF 154
++ + T ND WH VR+ R + +L +DQ+ K + + S LF
Sbjct: 858 NGPFEISVQSPTHFNDNQWHHVRVERNMKEASLQVDQLTPKTQPAPADGHVLLQLNSQLF 917
Query: 155 VGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGG 214
VGG R F G IR +++N + + +V + +P
Sbjct: 918 VGGTATRQRG---------------FLGCIRSLQLNGMTLDLEERAQVTPEVQPG----- 957
Query: 215 SPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEI 259
C G +C NGG C CDC+ + + G CS EI
Sbjct: 958 --CRGHCSSYGKLCRNGGKCRERPIGFFCDCTFSAYTGPFCSNEI 1000
Score = 62.0 bits (149), Expect = 4e-09
Identities = 91/382 (23%), Positives = 152/382 (39%), Gaps = 78/382 (20%)
Query: 781 DVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLF- 839
DVS F++ + G+ + AD +R+EL + V + + + GP +
Sbjct: 816 DVSFFFKTTASSGVFLENLG--IADFIRIELRSPTV--------VTFSFDVGNGPFEISV 865
Query: 840 -AGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGD-HTRLEFHN--IETGIITER 895
+ + NDN+WH VRV R K L VD T D H L+ ++ G T +
Sbjct: 866 QSPTHFNDNQWHHVRVERNMKEASLQVDQLTPKTQPAPADGHVLLQLNSQLFVGGTATRQ 925
Query: 896 RYLSSVPSNFIGHLQSLTFNGM-----------------------AYIDLCKNGDI---- 928
R F+G ++SL NGM +Y LC+NG
Sbjct: 926 R-------GFLGCIRSLQLNGMTLDLEERAQVTPEVQPGCRGHCSSYGKLCRNGGKCRER 978
Query: 929 ---------------DYC--ELNARFG-----FRNIIADPVTFKTKSSYVALATLQAYTS 966
+C E++A FG N + + K SS+ A S
Sbjct: 979 PIGFFCDCTFSAYTGPFCSNEISAYFGSGSSVIYNFQENYLLSKNSSSHAASFHGDMKLS 1038
Query: 967 MHLF-FQFKTTSLDGLILYNSGDGNDFIVVELVK-GYLHYVFDLGNGANL-IKGSSNKPL 1023
+ F F+TT L+L+ S +++ V + K G L + L + K +
Sbjct: 1039 REMIKFSFRTTRTPSLLLFVSSFYKEYLSVIIAKNGSLQIRYKLNKYQEPDVVNFDFKNM 1098
Query: 1024 NDNQWHNVMISRDTSNLHTVKIDTKITTQI--TAGARNLDLKSDLYIGGVAKETYKSLPK 1081
D Q H++MI+R+ + ++ID Q+ ++G +KS L +G + + +
Sbjct: 1099 ADGQLHHIMINRE-EGVVFIEIDDNRRRQVHLSSGTEFSAVKS-LVLGRILEHSDVDQDT 1156
Query: 1082 LVHAKEGFQGCLASVDLNGRLP 1103
+ +GF GCL++V L+ P
Sbjct: 1157 ALAGAQGFTGCLSAVQLSHVAP 1178
Score = 53.1 bits (126), Expect = 2e-06
Identities = 51/214 (23%), Positives = 92/214 (42%), Gaps = 20/214 (9%)
Query: 51 ESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVN 110
E +FQ +T + GL+L+ + + + L L+ G+L+ + P+ + A +N
Sbjct: 391 EVSATFQFRTWNKAGLLLFSELQLISGGILLFLS-DGKLKSNLYQPGKLPSDITAGVELN 449
Query: 111 DGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSG--LFVGGLPPELRAAALK 168
DG WHSV + + + ++ +D A + + ++SG + GG P + + K
Sbjct: 450 DGQWHSVSLSAKKNHLSVAVDGQMASAAPLLGPEQ---IYSGGTYYFGGCPDKSFGSKCK 506
Query: 169 LTLASVREREPFKGWIRDVRVNSSQV--LPVDSGEV-KLDDEPPNSGGGSPCEAGEEGEG 225
L F+G +R + ++ V + V G + D +S C +
Sbjct: 507 SPLGG------FQGCMRLISISGKVVDLISVQQGSLGNFSDLQIDS-----CGISDRCLP 555
Query: 226 GVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEI 259
C +GG CS C+C+ TG+RG C I
Sbjct: 556 NYCEHGGECSQSWSTFHCNCTNTGYRGATCHNSI 589
Score = 52.8 bits (125), Expect = 3e-06
Identities = 41/162 (25%), Positives = 76/162 (46%), Gaps = 28/162 (17%)
Query: 338 SDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAV-SLVINLGSGAFEALVEPVNGKFN 396
S +++ FKT +G+ L AD++ + L++ V + ++G+G FE V+ FN
Sbjct: 814 SADVSFFFKTTASSGVFLENLGIADFIRIELRSPTVVTFSFDVGNGPFEISVQSPT-HFN 872
Query: 397 DNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTISVDGILTTTGYTQED-YTMLGSDDFFY 455
DN WH V+V RN+++ S + VD + T D + +L + +
Sbjct: 873 DNQWHHVRVERNMKEAS---------------LQVDQLTPKTQPAPADGHVLLQLNSQLF 917
Query: 456 VGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAK 497
VGG+ + F+GC++ + + N + L+L A+
Sbjct: 918 VGGTATR--------QRGFLGCIRSL--QLNGMTLDLEERAQ 949
Score = 40.8 bits (94), Expect = 0.010
Identities = 41/194 (21%), Positives = 75/194 (38%), Gaps = 38/194 (19%)
Query: 1190 DRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVG------TDDIAIEES 1243
D +++ F T+Q + +L+ + +G D++ L + + ++ + N G T +
Sbjct: 206 DIISLKFKTMQSDGILLHREGPNG--DHITLQLRRARLFLLINSGEAKLPSTSTLVNLTL 263
Query: 1244 NAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVD 1303
++++D +H V R G VD ++ + R + Y +
Sbjct: 264 GSLLDDQHWHSVLIQRLGKQVNFTVDEHR--------HHFHARGEFNLMNLDYEI----- 310
Query: 1304 EWLLDKGRQLTIFNSQATIIIGGKEQGQP---FQGQLSGLYYNGLKVLNMAAENDANIAI 1360
S I GK P F G L LYYNG+ ++++A + I
Sbjct: 311 --------------SFGGIPAPGKSVSFPHRNFHGCLENLYYNGVDIIDLAKQQKPQIIA 356
Query: 1361 VGNVRLVGEVPSSM 1374
+GNV P SM
Sbjct: 357 MGNVSFSCSQPQSM 370
>gi|4505463 contactin associated protein 1 precursor [Homo sapiens]
Length = 1384
Score = 131 bits (329), Expect = 6e-30
Identities = 119/458 (25%), Positives = 191/458 (41%), Gaps = 76/458 (16%)
Query: 316 IATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHT-GKSADYVNLALKNGAVS 374
I F G + Y + +S D SFKT +++GL+LH G DYV L L+ +
Sbjct: 174 ILYFDGDDAISYRFPRGVSRSLWDVFAFSFKTEEKDGLLLHAEGAQGDYVTLELEGAHLL 233
Query: 375 LVINLGSGAFEA----LVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTIS 430
L ++LGS + G ND WH V+V R R
Sbjct: 234 LHMSLGSSPIQPRPGHTTVSAGGVLNDQHWHYVRVDRFGR-------------------- 273
Query: 431 VDGILTTTGYTQE-----DYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKN 485
D T GY Q D+ L D ++GG A +NF GC++ V++
Sbjct: 274 -DVNFTLDGYVQRFILNGDFERLNLDTEMFIGGLVGAAR-KNLAYRHNFRGCIENVIFN- 330
Query: 486 NDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPESFISLPKWNAKKTGSIS 545
R+ ++ LA + ++ G VAF+C + PI F P +F+ +P + + ++S
Sbjct: 331 ---RVNIADLAVRRHSRITFEGKVAFRCLDPVP-HPINFGGPHNFVQVPGFPRRGRLAVS 386
Query: 546 FDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIK- 604
F FRT + GL+LFS R H + + + +G + + + SG K++
Sbjct: 387 FRFRTWDLTGLLLFS----RLGDGLGHVE--------LTLSEGQVNVSIAQ-SGRKKLQF 433
Query: 605 ALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAG 664
A ++NDG W+ V+F IS++ + ++ + GG P+
Sbjct: 434 AAGYRLNDGFWHEVNFVAQENHAVISIDDVEGAEVRVSYPLLIRTGTSYFFGGCPK---- 489
Query: 665 LVFPTEVWTALLNY-GYVGCIRDLFIDGQSKDIRQM--------AEVQ-STAGVKPSCSK 714
P W N + GC+ L +DGQ ++ + AEV T G+ CS
Sbjct: 490 ---PASRWDCHSNQTAFHGCMELLKVDGQLVNLTLVEGRRLGFYAEVLFDTCGITDRCS- 545
Query: 715 ETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSC 752
N C+++G C W+ ++C C TGY G +C
Sbjct: 546 -------PNMCEHDGRCYQSWDDFICYCELTGYKGETC 576
Score = 107 bits (267), Expect = 9e-23
Identities = 106/425 (24%), Positives = 184/425 (43%), Gaps = 27/425 (6%)
Query: 752 CEREATVLSYDGSMFMKIQLPVVMHTEAEDV-SLRFRSQRAYGILMATTSRDSADTLRLE 810
C +A +L +DG + + P + DV + F+++ G+L+ D + LE
Sbjct: 168 CPYKADILYFDGDDAISYRFPRGVSRSLWDVFAFSFKTEEKDGLLLHAEGAQG-DYVTLE 226
Query: 811 LDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQA 870
L+ + L ++L I G T+ AG LND WH VRV R G+ + T+D
Sbjct: 227 LEGAHLLLHMSLGSSPIQ--PRPGHTTVSAGGVLNDQHWHYVRVDRFGRDVNFTLDGY-V 283
Query: 871 MTGQMAGDHTRLEFHNIET-----GIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLC-- 923
+ GD RL N++T G++ R + NF G ++++ FN + DL
Sbjct: 284 QRFILNGDFERL---NLDTEMFIGGLVGAARKNLAYRHNFRGCIENVIFNRVNIADLAVR 340
Query: 924 KNGDIDYCELNARFGFRNIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLIL 983
++ I + E F + + P+ F ++V + + + F+F+T L GL+L
Sbjct: 341 RHSRITF-EGKVAFRCLDPVPHPINFGGPHNFVQVPGFPRRGRLAVSFRFRTWDLTGLLL 399
Query: 984 YNS-GDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHT 1042
++ GDG + + L +G ++ V +G ++ ++ LND WH V N
Sbjct: 400 FSRLGDGLGHVELTLSEGQVN-VSIAQSGRKKLQFAAGYRLNDGFWHEVNFVAQ-ENHAV 457
Query: 1043 VKIDTKITTQITAGARNLDLKSDLYI-GGVAKETYKSLPKLVHAKE-GFQGCLASVDLNG 1100
+ ID ++ L Y GG K + H+ + F GC+ + ++G
Sbjct: 458 ISIDDVEGAEVRVSYPLLIRTGTSYFFGGCPKPASRWD---CHSNQTAFHGCMELLKVDG 514
Query: 1101 RLPDLI---SDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGP 1157
+L +L L ++ G + C + C + G C Q WD F C C +T + G
Sbjct: 515 QLVNLTLVEGRRLGFYAEVLFDTCGITDRCSPNMCEHDGRCYQSWDDFICYCELTGYKGE 574
Query: 1158 LCNDP 1162
C+ P
Sbjct: 575 TCHTP 579
Score = 84.3 bits (207), Expect = 8e-16
Identities = 123/545 (22%), Positives = 216/545 (39%), Gaps = 136/545 (24%)
Query: 926 GDIDYCELNARFGFRNI--IADPVTFKTKSSYVALAT----LQAYTSMHLFFQFKTTSLD 979
GD + A+F R + D ++ T S + A ++A S+ + F F+T++
Sbjct: 760 GDTNRSTSEAQFFLRPLRCYGDRNSWNTISFHTGAALRFPPIRANHSLDVSFYFRTSAPS 819
Query: 980 GLILYNSGDG-----NDFIVVEL-VKGYLHYVFDLGNG-ANLIKGSSNKPLNDNQWHNVM 1032
G+ L N G ++ VEL + + FD+GNG NL S + ND++WH V
Sbjct: 820 GVFLENMGGPYCQWRRPYVRVELNTSRDVVFAFDVGNGDENLTVHSDDFEFNDDEWHLVR 879
Query: 1033 ISRDTSNLHTVKIDTKITTQITAGARN---LDLKSDLYIGGVAKETYKSLPKLVHAKEGF 1089
+ +++D + + ++ LY+G + + F
Sbjct: 880 AEINVKQAR-LRVDHRPWVLRPMPLQTYIWMEYDQPLYVGSAELK-----------RRPF 927
Query: 1090 QGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQEDS------CSNQGVCLQQWD 1143
GCL ++ LNG +L A EG S C C + G C++++
Sbjct: 928 VGCLRAMRLNGVTLNLEGRA--------NASEGTSPNCTGHCAHPRLPCFHGGRCVERYS 979
Query: 1144 GFSCDCSMTSFSGPLCN-------DPGT-----------------TYIFSK--------- 1170
++CDC +T+F GP CN +PGT +++ S+
Sbjct: 980 YYTCDCDLTAFDGPYCNHDIGGFFEPGTWMRYNLQSALRSAAREFSHMLSRPVPGYEPGY 1039
Query: 1171 --------------GGGQITYKWPPNDRP---------STRADRLAIGFSTVQKEAVLVR 1207
G G +P RP + + ++ FST AVL+
Sbjct: 1040 IPGYDTPGYVPGYHGPGYRLPDYPRPGRPVPGYRGPVYNVTGEEVSFSFSTSSAPAVLLY 1099
Query: 1208 VDSSSGLGDYLELHI-HQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATL 1266
V SS + DY+ + I G + +++ +GT + + + DG+ H + TR N +
Sbjct: 1100 V--SSFVRDYMAVLIKDDGTLQLRYQLGTSPYVYQLTTRPVTDGQPHSINITRVYRNLFI 1157
Query: 1267 QVDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQATIIIGG 1326
QVD +P+ E+ + D++ + + Y LGRV++ ++D ++ +N+
Sbjct: 1158 QVDYFPLTEQKFSLLVDSQ---LDSPKALY-LGRVMETGVIDP--EIQRYNTPG------ 1205
Query: 1327 KEQGQPFQGQLSGLYYNGLKVLN--------MAAENDANIAIVGNV---------RLVGE 1369
F G LSG+ +N + L M AE + + G + RLV E
Sbjct: 1206 ------FSGCLSGVRFNNVAPLKTHFRTPRPMTAELAEALRVQGELSESNCGAMPRLVSE 1259
Query: 1370 VPSSM 1374
VP +
Sbjct: 1260 VPPEL 1264
Score = 61.2 bits (147), Expect = 7e-09
Identities = 61/268 (22%), Positives = 118/268 (44%), Gaps = 36/268 (13%)
Query: 522 ITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFF 581
I+F T + + P A + +SF FRT+ P+G+ L + G P Q + ++V+
Sbjct: 788 ISFHTGAA-LRFPPIRANHSLDVSFYFRTSAPSGVFLENMGGPYCQWRRPY---VRVELN 843
Query: 582 AIEMLDGHLYLLLDMGSG--TIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYT 639
+ D+G+G + + + + ND EW+ V + + + + V+ P+
Sbjct: 844 TSR----DVVFAFDVGNGDENLTVHSDDFEFNDDEWHLVRAEINVKQARLRVD--HRPWV 897
Query: 640 A---PGESEI-LDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKD 695
P ++ I ++ D LY+G L +VGC+R + ++G + +
Sbjct: 898 LRPMPLQTYIWMEYDQPLYVGS---------------AELKRRPFVGCLRAMRLNGVTLN 942
Query: 696 IRQMAEVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCERE 755
+ A ++ G P+C+ A P L PC + G C + ++ Y CDC T + G C +
Sbjct: 943 LEGRAN--ASEGTSPNCTGHCAHPRL--PCFHGGRCVERYSYYTCDCDLTAFDGPYCNHD 998
Query: 756 ATVLSYDGSMFMKIQLPVVMHTEAEDVS 783
++ +M+ L + + A + S
Sbjct: 999 IGGF-FEPGTWMRYNLQSALRSAAREFS 1025
Score = 46.2 bits (108), Expect = 2e-04
Identities = 31/98 (31%), Positives = 47/98 (47%), Gaps = 2/98 (2%)
Query: 34 PGAEGQWTRFPKWNACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSF 93
PG R P +N E E+SF T SA ++LY D++ +++ G LQL +
Sbjct: 1065 PGRPVPGYRGPVYNVTGE-EVSFSFSTSSAPAVLLYVSSF-VRDYMAVLIKDDGTLQLRY 1122
Query: 94 SIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLFID 131
+ + L PV DG HS+ I R +RN + +D
Sbjct: 1123 QLGTSPYVYQLTTRPVTDGQPHSINITRVYRNLFIQVD 1160
Score = 44.3 bits (103), Expect = 0.001
Identities = 58/247 (23%), Positives = 92/247 (37%), Gaps = 31/247 (12%)
Query: 21 LGCWAELGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKTRSARGLVLYFDDEGFCD--- 77
L C+ + S G RFP A ++SF +T + G+ L +C
Sbjct: 776 LRCYGDRNSWNTISFHTGAALRFPPIRANHSLDVSFYFRTSAPSGVFLENMGGPYCQWRR 835
Query: 78 -FLELILTRGGRLQLSFSIFCAEPATLLA--DTPVNDGAWHSVRIRRQFRNTTLFIDQVE 134
++ + L + +F + + + D ND WH VR + L +D
Sbjct: 836 PYVRVELNTSRDVVFAFDVGNGDENLTVHSDDFEFNDDEWHLVRAEINVKQARLRVDH-- 893
Query: 135 AKWVEVKSKRRDMTVFSGLFVG-GLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQ 193
WV R M + + +++ P + +A LK R PF G +R +R+N
Sbjct: 894 RPWV-----LRPMPLQTYIWMEYDQPLYVGSAELK--------RRPFVGCLRAMRLNGVT 940
Query: 194 VLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGV-CLNGGVCSVVDDQAVCDCSRTGFRG 252
+ L+ S G SP G + C +GG C CDC T F G
Sbjct: 941 L--------NLEGRANASEGTSPNCTGHCAHPRLPCFHGGRCVERYSYYTCDCDLTAFDG 992
Query: 253 KDCSQEI 259
C+ +I
Sbjct: 993 PYCNHDI 999
Score = 42.7 bits (99), Expect = 0.003
Identities = 52/214 (24%), Positives = 78/214 (36%), Gaps = 34/214 (15%)
Query: 54 MSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGA 113
+SF+ +T GL+L+ +EL L+ G ++ +S + + A +NDG
Sbjct: 385 VSFRFRTWDLTGLLLFSRLGDGLGHVELTLSEG-QVNVSIAQSGRKKLQFAAGYRLNDGF 443
Query: 114 WHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLAS 173
WH V Q + + ID VE V V T S F GG P
Sbjct: 444 WHEVNFVAQENHAVISIDDVEGAEVRVSYPLLIRTGTS-YFFGGCP-------------- 488
Query: 174 VREREPFKGWIRDVRVNSS------QVLPVDSGEVKLDDEPPNSGG------GSPCEAGE 221
+P W D N + ++L VD V L G C +
Sbjct: 489 ----KPASRW--DCHSNQTAFHGCMELLKVDGQLVNLTLVEGRRLGFYAEVLFDTCGITD 542
Query: 222 EGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDC 255
+C + G C D +C C TG++G+ C
Sbjct: 543 RCSPNMCEHDGRCYQSWDDFICYCELTGYKGETC 576
Score = 41.2 bits (95), Expect = 0.008
Identities = 32/129 (24%), Positives = 62/129 (48%), Gaps = 16/129 (12%)
Query: 1167 IFSKGGGQITYKWPPNDRPSTRA--DRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQ 1224
++ G I+Y++P R +R+ D A F T +K+ +L+ + + G DY+ L +
Sbjct: 175 LYFDGDDAISYRFP---RGVSRSLWDVFAFSFKTEEKDGLLLHAEGAQG--DYVTLELEG 229
Query: 1225 GKIGVKFNVGTDDI------AIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYP 1278
+ + ++G+ I + ++ND +H VR R G + +D + ++R+
Sbjct: 230 AHLLLHMSLGSSPIQPRPGHTTVSAGGVLNDQHWHYVRVDRFGRDVNFTLDGY--VQRFI 287
Query: 1279 AGNNDNERL 1287
N D ERL
Sbjct: 288 L-NGDFERL 295
Score = 34.7 bits (78), Expect = 0.74
Identities = 45/168 (26%), Positives = 73/168 (43%), Gaps = 20/168 (11%)
Query: 31 LEFPGAEGQWTRFPKW-NACCESEMSFQLKTRSARGLVLYFDD-EGFCDFLELILTRGGR 88
L F G + RFP+ + +F KT GL+L+ + +G LEL G
Sbjct: 175 LYFDGDDAISYRFPRGVSRSLWDVFAFSFKTEEKDGLLLHAEGAQGDYVTLEL---EGAH 231
Query: 89 LQLSFSIFCA--EP----ATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKS 142
L L S+ + +P T+ A +ND WH VR+ R R+ +D +++ +
Sbjct: 232 LLLHMSLGSSPIQPRPGHTTVSAGGVLNDQHWHYVRVDRFGRDVNFTLDGYVQRFI-LNG 290
Query: 143 KRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVN 190
+ + + +F+GGL A + LA R F+G I +V N
Sbjct: 291 DFERLNLDTEMFIGGL-----VGAARKNLA---YRHNFRGCIENVIFN 330
Score = 32.7 bits (73), Expect = 2.8
Identities = 26/101 (25%), Positives = 41/101 (40%), Gaps = 7/101 (6%)
Query: 769 IQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRIN 828
++ P + + DVS FR+ G+ + R + RV+L + D +
Sbjct: 796 LRFPPIRANHSLDVSFYFRTSAPSGVFLENMGGPYCQWRRPYV---RVELNTSRDVV-FA 851
Query: 829 CNSSKGPETLFA---GYNLNDNEWHTVRVVRRGKSLKLTVD 866
+ G E L + ND+EWH VR K +L VD
Sbjct: 852 FDVGNGDENLTVHSDDFEFNDDEWHLVRAEINVKQARLRVD 892
>gi|18640734 contactin associated protein-like 5 [Homo sapiens]
Length = 1306
Score = 127 bits (318), Expect = 1e-28
Identities = 123/465 (26%), Positives = 200/465 (43%), Gaps = 65/465 (13%)
Query: 752 CEREATVLSYDGSMFMKIQL-PVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLE 810
C ++ V +DG + + +M T + +SL+F+S + G+L + D + LE
Sbjct: 174 CSYKSDVADFDGRSSLLYRFNQKLMSTLKDVISLKFKSMQGDGVLFHGEGQ-RGDHITLE 232
Query: 811 LDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQ-Q 869
L GR+ L +NL + +SS TL G L+D WH+V + R GK + TVD Q
Sbjct: 233 LQKGRLALHLNLGDSKARLSSSLPSATL--GSLLDDQHWHSVLIERVGKQVNFTVDKHTQ 290
Query: 870 AMTGQMAGDHTRLEFHNIETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDID 929
+ D +++ GI + + + NF G +++L +NG+ IDL K
Sbjct: 291 HFRTKGETDALDIDYELSFGGIPVPGKPGTFLKKNFHGCIENLYYNGVNIIDLAKRRKHQ 350
Query: 930 YCELNARFGFRNIIADPVTFKTKS-SYVALATLQAYTSMHLFFQFKTTSLDGLILYNS-G 987
N F P+TF S SY+ L + + FQF+T + DGL+L
Sbjct: 351 IYTGNVTFSCSEPQIVPITFVNSSGSYLLLPGTPQIDGLSVSFQFRTWNKDGLLLSTELS 410
Query: 988 DGNDFIVVELVKGYLHYVFD--LGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKI 1045
+G+ +++ L G L V A ++ GS+ LND WH+V I+ + + T+ +
Sbjct: 411 EGSGTLLLSLEGGILRLVIQKMTERVAEILTGSN---LNDGLWHSVSINARRNRI-TLTL 466
Query: 1046 DTKIT--------TQITAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVD 1097
D + QI +G + Y GG S + ++ + FQGC+ +
Sbjct: 467 DDEAAPPAPDSTWVQIYSG-------NSYYFGGCPDNLTDS--QCLNPIKAFQGCMRLIF 517
Query: 1098 LNGRLPDLISDALFCNGQIERGCEGPSTT-----------CQEDSCSNQGVCLQQWDGFS 1146
++ + DLIS +++G G + C + C + G C Q W F
Sbjct: 518 IDNQPKDLIS--------VQQGSLGNFSDLHIDLCSIKDRCLPNYCEHGGSCSQSWTTFY 569
Query: 1147 CDCSMTSFSGPLC----------------NDPGTTYIFSKGGGQI 1175
C+CS TS++G C N G YI S G G +
Sbjct: 570 CNCSDTSYTGATCHNSIYEQSCEVYRHQGNTAGFFYIDSDGSGPL 614
Score = 126 bits (316), Expect = 2e-28
Identities = 130/492 (26%), Positives = 220/492 (44%), Gaps = 77/492 (15%)
Query: 947 VTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVK-GYLHYV 1005
V+F T++SY+ T A S + F FKTT+L G+ L N G DFI +E+ + +
Sbjct: 793 VSFYTEASYLHFPTFHAEFSADISFFFKTTALSGVFLENLGI-KDFIRLEISSPSEITFA 851
Query: 1006 FDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITA--GARNLDLK 1063
D+GNG + S LNDNQWH V R+ + +T+ T+ G L L
Sbjct: 852 IDVGNGPVELVVQSPSLLNDNQWHYVRAERNLKETSLQVDNLPRSTRETSEEGHFRLQLN 911
Query: 1064 SDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGP 1123
S L++GG + ++GF GC+ S+ LNG+ DL A +G + GC G
Sbjct: 912 SQLFVGGTSSR-----------QKGFLGCIRSLHLNGQKMDLEERAKVTSG-VRPGCPGH 959
Query: 1124 STTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCN-------DPGT--TYIFSKGGGQ 1174
++ C N G C+++ +G+ CDC+ + + GP C + GT TY+F Q
Sbjct: 960 CSS-YGSICHNGGKCVEKHNGYLCDCTNSPYEGPFCKKEVSAVFEAGTSVTYMF-----Q 1013
Query: 1175 ITYKWPPNDRPSTRA---------DRLAIGFSTVQKEAVLVRVDSSSGLGDY-LELHIHQ 1224
Y N S+ A + +A+ F T Q ++L+ ++SSS D+ + L
Sbjct: 1014 EPYPVTKNISLSSSAIYTDSAPSKENIALSFVTTQAPSLLLFINSSS--QDFVVVLLCKN 1071
Query: 1225 GKIGVKFNVGTDDIAIEESNA-IINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNND 1283
G + V++++ ++ + +A + + H ++ R G T+Q+D
Sbjct: 1072 GSLQVRYHLNKEETHVFTIDADNFANRRMHHLKINREGRELTIQMD-------------- 1117
Query: 1284 NERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQATIIIGGKEQGQPFQGQLSGLYYN 1343
++L ++ P RV+ L K + +S+ K F G +S + YN
Sbjct: 1118 -QQLRLSYNFSPEVEFRVIRSLTLGKVTENLGLDSEV-----AKANAMGFAGCMSSVQYN 1171
Query: 1344 GLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSEMSTSIMETTTTLATSTA 1403
+ L AA A +A V V ++T S + S+++ TT+ +S+
Sbjct: 1172 HIAPLK-AALRHATVAPV-------TVHGTLTESSCGFMVDSDVN-----AVTTVHSSSD 1218
Query: 1404 RRGKPPTKEPIS 1415
GK +EP++
Sbjct: 1219 PFGKTDEREPLT 1230
Score = 115 bits (289), Expect = 3e-25
Identities = 117/460 (25%), Positives = 193/460 (41%), Gaps = 80/460 (17%)
Query: 316 IATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLH-TGKSADYVNLALKNGAVS 374
+A F G Y +Q + + D I+L FK++Q +G++ H G+ D++ L L+ G ++
Sbjct: 180 VADFDGRSSLLYRFNQKLMSTLKDVISLKFKSMQGDGVLFHGEGQRGDHITLELQKGRLA 239
Query: 375 LVINLGSGAFE---ALVEPVNGKF-NDNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTIS 430
L +NLG +L G +D WH V + R +Q V +
Sbjct: 240 LHLNLGDSKARLSSSLPSATLGSLLDDQHWHSVLIERVGKQ---------------VNFT 284
Query: 431 VDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRL 490
VD T T+ + L D GG P PG+ + NF GC++ + Y ++ +
Sbjct: 285 VDKH-TQHFRTKGETDALDIDYELSFGGIPVPGK-PGTFLKKNFHGCIENLYYNGVNI-I 341
Query: 491 ELSRLAKQGDPKMKIH-GVVAFKCENVATLDPITF-ETPESFISLPKWNAKKTGSISFDF 548
+L++ K +I+ G V F C + PITF + S++ LP S+SF F
Sbjct: 342 DLAKRRKH-----QIYTGNVTFSCSEPQIV-PITFVNSSGSYLLLPGTPQIDGLSVSFQF 395
Query: 549 RTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIK--IKAL 606
RT +GL+L + E+ +G LLL + G ++ I+ +
Sbjct: 396 RTWNKDGLLL-----------------------STELSEGSGTLLLSLEGGILRLVIQKM 432
Query: 607 LKKV---------NDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGG 657
++V NDG W+ V T++++ P + + Y GG
Sbjct: 433 TERVAEILTGSNLNDGLWHSVSINARRNRITLTLDDEAAPPAPDSTWVQIYSGNSYYFGG 492
Query: 658 LPENKAGLVFPTEVWTALLN--YGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKE 715
P+N + LN + GC+R +FID Q KD+ ++ Q + G +
Sbjct: 493 CPDNLTD--------SQCLNPIKAFQGCMRLIFIDNQPKDL--ISVQQGSLGNFSDLHID 542
Query: 716 TAK---PCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSC 752
CL N C++ G C W + C+CS T Y G +C
Sbjct: 543 LCSIKDRCLPNYCEHGGSCSQSWTTFYCNCSDTSYTGATC 582
Score = 109 bits (273), Expect = 2e-23
Identities = 97/416 (23%), Positives = 187/416 (44%), Gaps = 53/416 (12%)
Query: 522 ITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFF 581
++F T S++ P ++A+ + ISF F+TT +G+ L + G IK DF
Sbjct: 793 VSFYTEASYLHFPTFHAEFSADISFFFKTTALSGVFLENLG-------------IK-DFI 838
Query: 582 AIEMLD-GHLYLLLDMGSGTIKIKALLKKV-NDGEWYHVDFQRDGRSGTISVNTL--RTP 637
+E+ + +D+G+G +++ + ND +W++V +R+ + ++ V+ L T
Sbjct: 839 RLEISSPSEITFAIDVGNGPVELVVQSPSLLNDNQWHYVRAERNLKETSLQVDNLPRSTR 898
Query: 638 YTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIR 697
T+ L L+ +L++GG T+ G++GCIR L ++GQ D+
Sbjct: 899 ETSEEGHFRLQLNSQLFVGG---------------TSSRQKGFLGCIRSLHLNGQKMDLE 943
Query: 698 QMAEVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREAT 757
+ A+V T+GV+P C + + C N G C + N Y+CDC+ + Y G C++E +
Sbjct: 944 ERAKV--TSGVRPGCPGHCSS--YGSICHNGGKCVEKHNGYLCDCTNSPYEGPFCKKEVS 999
Query: 758 VLSYDGS----MFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDA 813
+ G+ MF + PV + ++ S + + + A +L L +++
Sbjct: 1000 AVFEAGTSVTYMFQE-PYPVTKNISLSSSAIYTDSAPSKENIALSFVTTQAPSLLLFINS 1058
Query: 814 GRVKLTVNLDC------IRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDD 867
V L C +R + N + N + H +++ R G+ L + +D
Sbjct: 1059 SSQDFVVVLLCKNGSLQVRYHLNKEETHVFTIDADNFANRRMHHLKINREGRELTIQMDQ 1118
Query: 868 QQAMTGQMAGDHTRLEFHNIETGIITERRYLSSVPS-----NFIGHLQSLTFNGMA 918
Q ++ + + ++ G +TE L S + F G + S+ +N +A
Sbjct: 1119 QLRLSYNFSPEVEFRVIRSLTLGKVTENLGLDSEVAKANAMGFAGCMSSVQYNHIA 1174
Score = 71.6 bits (174), Expect = 5e-12
Identities = 55/226 (24%), Positives = 98/226 (43%), Gaps = 28/226 (12%)
Query: 37 EGQWTRFPKWNACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIF 96
E + FP ++A +++SF KT + G+ L ++ G DF+ L ++ + + +
Sbjct: 798 EASYLHFPTFHAEFSADISFFFKTTALSGVFL--ENLGIKDFIRLEISSPSEITFAIDVG 855
Query: 97 CAEPATLLADTP--VNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRR-DMTVFSGL 153
P L+ +P +ND WH VR R + T+L +D + E + + + S L
Sbjct: 856 NG-PVELVVQSPSLLNDNQWHYVRAERNLKETSLQVDNLPRSTRETSEEGHFRLQLNSQL 914
Query: 154 FVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGG 213
FVGG + ++ F G IR + +N ++ + +V SG
Sbjct: 915 FVGG---------------TSSRQKGFLGCIRSLHLNGQKMDLEERAKV-------TSGV 952
Query: 214 GSPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEI 259
C G +C NGG C + +CDC+ + + G C +E+
Sbjct: 953 RPGCPGHCSSYGSICHNGGKCVEKHNGYLCDCTNSPYEGPFCKKEV 998
Score = 52.4 bits (124), Expect = 3e-06
Identities = 57/243 (23%), Positives = 94/243 (38%), Gaps = 38/243 (15%)
Query: 31 LEFPGAEGQWTRFPKWNACCESEMSFQLKTRSARGLVLYFD-DEGFCDFLELILTRGGRL 89
+ F + G + P +SFQ +T + GL+L + EG L + GG L
Sbjct: 368 ITFVNSSGSYLLLPGTPQIDGLSVSFQFRTWNKDGLLLSTELSEGSGTLL--LSLEGGIL 425
Query: 90 QLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQ------VEAKWVEVKSK 143
+L A +L + +NDG WHSV I + TL +D ++ WV++ S
Sbjct: 426 RLVIQKMTERVAEILTGSNLNDGLWHSVSINARRNRITLTLDDEAAPPAPDSTWVQIYSG 485
Query: 144 RRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNS--SQVLPVDSGE 201
+ + GG P L + + + F+G +R + +++ ++ V G
Sbjct: 486 -------NSYYFGGCPDNLTDS------QCLNPIKAFQGCMRLIFIDNQPKDLISVQQGS 532
Query: 202 VKLDDEPPNSGGGSP-----CEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCS 256
+ G S C + C +GG CS C+CS T + G C
Sbjct: 533 L---------GNFSDLHIDLCSIKDRCLPNYCEHGGSCSQSWTTFYCNCSDTSYTGATCH 583
Query: 257 QEI 259
I
Sbjct: 584 NSI 586
Score = 52.4 bits (124), Expect = 3e-06
Identities = 86/385 (22%), Positives = 145/385 (37%), Gaps = 74/385 (19%)
Query: 776 HTE-AEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKG 834
H E + D+S F++ G+ + D +RLE+ + ++T +D G
Sbjct: 808 HAEFSADISFFFKTTALSGVFLENLG--IKDFIRLEISSPS-EITFAIDV-------GNG 857
Query: 835 PETLFAGYN--LNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGD-HTRLEFHN-IETG 890
P L LNDN+WH VR R K L VD+ T + + + H RL+ ++ + G
Sbjct: 858 PVELVVQSPSLLNDNQWHYVRAERNLKETSLQVDNLPRSTRETSEEGHFRLQLNSQLFVG 917
Query: 891 IITERRYLSSVPSNFIGHLQSLTFNGM-----------------------AYIDLCKNG- 926
+ R+ F+G ++SL NG +Y +C NG
Sbjct: 918 GTSSRQ------KGFLGCIRSLHLNGQKMDLEERAKVTSGVRPGCPGHCSSYGSICHNGG 971
Query: 927 ------------------DIDYC--ELNARFGFRNIIAD------PVTFKTKSSYVALAT 960
+ +C E++A F + PVT S A+ T
Sbjct: 972 KCVEKHNGYLCDCTNSPYEGPFCKKEVSAVFEAGTSVTYMFQEPYPVTKNISLSSSAIYT 1031
Query: 961 LQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVK-GYLHYVFDLGNGANLIKGSS 1019
A + ++ F TT L+L+ + DF+VV L K G L + L +
Sbjct: 1032 DSAPSKENIALSFVTTQAPSLLLFINSSSQDFVVVLLCKNGSLQVRYHLNKEETHVFTID 1091
Query: 1020 NKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGAR-NLDLKSDLYIGGVAKETYKS 1078
+ + H++ I+R+ L T+++D ++ + L +G V +
Sbjct: 1092 ADNFANRRMHHLKINREGREL-TIQMDQQLRLSYNFSPEVEFRVIRSLTLGKVTENLGLD 1150
Query: 1079 LPKLVHAKEGFQGCLASVDLNGRLP 1103
GF GC++SV N P
Sbjct: 1151 SEVAKANAMGFAGCMSSVQYNHIAP 1175
Score = 50.4 bits (119), Expect = 1e-05
Identities = 39/156 (25%), Positives = 72/156 (46%), Gaps = 26/156 (16%)
Query: 338 SDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGA-VSLVINLGSGAFEALVEPVNGKFN 396
S +I+ FKT +G+ L D++ L + + + ++ I++G+G E +V+ + N
Sbjct: 812 SADISFFFKTTALSGVFLENLGIKDFIRLEISSPSEITFAIDVGNGPVELVVQSPS-LLN 870
Query: 397 DNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTISVDGILTTTGYTQED-YTMLGSDDFFY 455
DN WH V+ RNL++ S + VD + +T T E+ + L + +
Sbjct: 871 DNQWHYVRAERNLKETS---------------LQVDNLPRSTRETSEEGHFRLQLNSQLF 915
Query: 456 VGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLE 491
VGG+ S F+GC++ + + LE
Sbjct: 916 VGGTSSR--------QKGFLGCIRSLHLNGQKMDLE 943
Score = 36.6 bits (83), Expect = 0.19
Identities = 43/188 (22%), Positives = 72/188 (38%), Gaps = 39/188 (20%)
Query: 1186 STRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEES-- 1243
ST D +++ F ++Q + VL + G D++ L + +G++ + N+G + S
Sbjct: 199 STLKDVISLKFKSMQGDGVLFHGEGQRG--DHITLELQKGRLALHLNLGDSKARLSSSLP 256
Query: 1244 ----NAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLG 1299
++++D +H V R G VD R G D I Y L
Sbjct: 257 SATLGSLLDDQHWHSVLIERVGKQVNFTVDKHTQHFR-TKGETD-------ALDIDYEL- 307
Query: 1300 RVVDEWLLDKGRQLTIFNSQATIIIGGKE---QGQPFQGQLSGLYYNGLKVLNMAAENDA 1356
S I + GK + F G + LYYNG+ ++++A
Sbjct: 308 ------------------SFGGIPVPGKPGTFLKKNFHGCIENLYYNGVNIIDLAKRRKH 349
Query: 1357 NIAIVGNV 1364
I GNV
Sbjct: 350 QI-YTGNV 356
>gi|33469931 EGF-like, fibronectin type III and laminin G domains
isoform 2 [Homo sapiens]
Length = 775
Score = 126 bits (316), Expect = 2e-28
Identities = 151/690 (21%), Positives = 284/690 (41%), Gaps = 133/690 (19%)
Query: 303 MGDQGKSKGKEEYIA--TFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGKS 360
+G G+S ++ I F G Y ++ +N Q+ +ITL F+ +GL+L+ G++
Sbjct: 139 LGKGGESCSEDIVIQYPQFFGHSYVTFEPLKNSYQAF--QITLEFRAEAEDGLLLYCGEN 196
Query: 361 ----ADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIG 416
D+++LA+ ++ N G+G + E K WH V + R+
Sbjct: 197 EHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSET---KIKLGGWHTVMLYRD-------- 245
Query: 417 HAMVNKLHCSVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNN-FM 475
+N L + ++ TG +Q Y+ + Y+GG+PS L + +N F
Sbjct: 246 --GLNGL-----LQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQ 298
Query: 476 GCLKEVVYKNNDVRLELSRLAKQ-------------GDPKMKIHG--VVAFKCENVATLD 520
GC++ + + + L K D IHG A K ++ L
Sbjct: 299 GCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCTAIKADSYICLC 358
Query: 521 PITF-----------------ETPESFISLPKWNAKKTGSISF-----DFRTTEPNGLIL 558
P+ F E+ S+ + P W + +SF FR +G++L
Sbjct: 359 PLGFKGRHCEDAFTLTIPQFRESLRSYAATP-WPLEPQHYLSFMEFEITFRPDSGDGVLL 417
Query: 559 FSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHV 618
+S+ DF +I + GH+ D GSGT +++ + G W+ +
Sbjct: 418 YSYDTGSK------------DFLSINLAGGHVEFRFDCGSGTGVLRSE-DPLTLGNWHEL 464
Query: 619 DFQRDGRSGTISVNTLR-TPYTAPGESEILDLDDELYLGGLP-----ENKAGLVFPTEVW 672
R ++G + V+ + A G + + ++++GG+P + +G++ P
Sbjct: 465 RVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKP---- 520
Query: 673 TALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPCLSNPCKNNGMCR 732
+ G I+ + ++ ++ ++ T+GV + A PC+ PC + G CR
Sbjct: 521 -------FSGSIQKIILNDRTIHVKH----DFTSGVNV---ENAAHPCVRAPCAHGGSCR 566
Query: 733 DGWNRYVCDCSGTGYLGRSCEREAT----VLSYDGSMFMKIQLPVVMHTEA---EDVSLR 785
Y CDC G+ G C++ + + G ++ P ++ + +V +R
Sbjct: 567 PRKEGYDCDCP-LGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMR 625
Query: 786 FRSQRAYGILM---ATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLFAGY 842
F++ G+L+ + R ++D + L L G + + NL G ++
Sbjct: 626 FKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNL---------GSGVASIMVNG 676
Query: 843 NLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNI-------ETGIITER 895
+ ND WH V+ VR G+S K+TVDD A TG+ G +L + E + T R
Sbjct: 677 SFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNR 736
Query: 896 RYLSSVPSNFIGHLQSLTFNGMAYIDLCKN 925
+Y+ + +G + T + +I L ++
Sbjct: 737 QYMRGL----VGCISHFTLSTDYHISLVED 762
Score = 120 bits (301), Expect = 1e-26
Identities = 145/620 (23%), Positives = 245/620 (39%), Gaps = 96/620 (15%)
Query: 719 PCLSNPCKNNGMCRDG--WNRYVCDCSGTGYLGRSCEREATVL--SYDGSMFMKIQLPVV 774
PC C + C + W C C+ G G SC + + + G ++ + P+
Sbjct: 112 PCDETLCSADSFCVNDYTWGGSRCQCT-LGKGGESCSEDIVIQYPQFFGHSYVTFE-PLK 169
Query: 775 MHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKG 834
+A ++L FR++ G+L+ + + L R L R NC + G
Sbjct: 170 NSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQ-----FRFNCGT--G 222
Query: 835 PETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETGIITE 894
+ + + WHTV + R G + L +++ +TGQ G ++++ F
Sbjct: 223 VAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRT-------- 274
Query: 895 RRYLSSVPS------------NFIGHLQSLTFNGM---------------AYIDLCKNGD 927
YL PS F G +QSL NG A + C +G
Sbjct: 275 PLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGI 334
Query: 928 IDYCELNARFGFRNIIAD------PVTFKTKSSYVALA--------TLQAYTS------- 966
D I AD P+ FK + A +L++Y +
Sbjct: 335 CDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEP 394
Query: 967 ------MHLFFQFKTTSLDGLILYNSGDGN-DFIVVELVKGYLHYVFDLGNGANLIKGSS 1019
M F+ S DG++LY+ G+ DF+ + L G++ + FD G+G +++ S
Sbjct: 395 QHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLR--S 452
Query: 1020 NKPLNDNQWHNVMISRDTSNLHTVKIDTK--ITTQITAGARNLDLKSDLYIGGVAKETYK 1077
PL WH + +SR N +++D + + G + +D++IGGV Y
Sbjct: 453 EDPLTLGNWHELRVSRTAKN-GILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPN--YD 509
Query: 1078 SLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGV 1137
+ K + F G + + LN R + D F +G E + C C++ G
Sbjct: 510 DVKKNSGVLKPFSGSIQKIILNDRTIHVKHD--FTSGV---NVENAAHPCVRAPCAHGGS 564
Query: 1138 CLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSK---GGGQITYKWPP-NDRPSTRADRLA 1193
C + +G+ CDC + F G C I G +TY P R S +
Sbjct: 565 CRPRKEGYDCDCPL-GFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVF 623
Query: 1194 IGFSTVQKEAVLV-RVDS-SSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGK 1251
+ F T K+ +L+ R DS D++ L + G + +N+G+ +A N NDG+
Sbjct: 624 MRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGS-GVASIMVNGSFNDGR 682
Query: 1252 YHVVRFTRSGGNATLQVDSW 1271
+H V+ R G + + VD +
Sbjct: 683 WHRVKAVRDGQSGKITVDDY 702
Score = 101 bits (251), Expect = 6e-21
Identities = 91/339 (26%), Positives = 147/339 (43%), Gaps = 22/339 (6%)
Query: 954 SYVALATLQ-AYTSMHLFFQFKTTSLDGLILY---NSGDGNDFIVVELVKGYLHYVFDLG 1009
SYV L+ +Y + + +F+ + DGL+LY N DF+ + +++ L + F+ G
Sbjct: 161 SYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCG 220
Query: 1010 NGANLIKGSSNKPLNDNQWHNVMISRDTSN-LHTVKIDTKITTQITAGARNLDLKSDLYI 1068
G +I + L WH VM+ RD N L + T +T Q + ++ LY+
Sbjct: 221 TGVAIIVSETKIKLGG--WHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYL 278
Query: 1069 GGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGC---EGPST 1125
GG + L + GFQGC+ S+ +NGR D+ L G+ G E S
Sbjct: 279 GGAPSAYW--LVRATGTNRGFQGCVQSLAVNGRRIDMRPWPL---GKALSGADVGECSSG 333
Query: 1126 TCQEDSCSNQGVCLQ-QWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITY---KWPP 1181
C E SC + G C + D + C C + F G C D T I +Y WP
Sbjct: 334 ICDEASCIHGGTCTAIKADSYICLCPL-GFKGRHCEDAFTLTIPQFRESLRSYAATPWPL 392
Query: 1182 NDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIE 1241
+ I F + VL+ +G D+L +++ G + +F+ G+ +
Sbjct: 393 EPQHYLSFMEFEITFRPDSGDGVLL-YSYDTGSKDFLSINLAGGHVEFRFDCGS-GTGVL 450
Query: 1242 ESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAG 1280
S + G +H +R +R+ N LQVD ++E G
Sbjct: 451 RSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEG 489
Score = 90.9 bits (224), Expect = 9e-18
Identities = 108/444 (24%), Positives = 164/444 (36%), Gaps = 113/444 (25%)
Query: 52 SEMSFQLKTR--SARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAE-PATLLADTP 108
S M F++ R S G++LY D G DFL + L GG ++ F C L ++ P
Sbjct: 399 SFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLA-GGHVEFRFD--CGSGTGVLRSEDP 455
Query: 109 VNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLP----PELRA 164
+ G WH +R+ R +N L +D+ + + + + +F+GG+P + +
Sbjct: 456 LTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNS 515
Query: 165 AALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGE 224
LK PF G I+ + +N + VK D + G + A
Sbjct: 516 GVLK----------PFSGSIQKIILNDRTI------HVKHD----FTSGVNVENAAHPCV 555
Query: 225 GGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEIKFGLQCVLPVLLHDNDQGKYCCINT 284
C +GG C + CDC GF G C + I ++
Sbjct: 556 RAPCAHGGSCRPRKEGYDCDCP-LGFEGLHCQKAIIEAIE-------------------- 594
Query: 285 AKPLTEKDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNP-----IQSSSD 339
I F G Y YD NP + S
Sbjct: 595 -------------------------------IPQFIGRSYLTYD---NPDILKRVSGSRS 620
Query: 340 EITLSFKTLQRNGLMLHTGKS-----ADYVNLALKNGAVSLVINLGSGAFEALVEPVNGK 394
+ + FKT ++GL+L G S +D+++L L++GA+ NLGSG + VNG
Sbjct: 621 NVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIM---VNGS 677
Query: 395 FNDNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTISVDGILTTTGYTQEDYTMLGSDDFF 454
FND WH VK R+ + S I+VD TG + L +
Sbjct: 678 FNDGRWHRVKAVRDGQ---------------SGKITVDDYGARTGKSPGMMRQLNINGAL 722
Query: 455 YVGGSPSTADLPGSPVSNNFMGCL 478
YVGG A +GC+
Sbjct: 723 YVGGMKEIALHTNRQYMRGLVGCI 746
Score = 53.9 bits (128), Expect = 1e-06
Identities = 54/221 (24%), Positives = 98/221 (44%), Gaps = 29/221 (13%)
Query: 44 PKWNACCESEMSFQLKTRSARGLVLYF--DDEGFCDFLELILTRGGRLQLSFSIFCAEP- 100
P N+ +++ + + + GL+LY ++ G DF+ L + R L F C
Sbjct: 167 PLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRS---LQFRFNCGTGV 223
Query: 101 ATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPP 160
A ++++T + G WH+V + R N L ++ + + + +T + L++GG P
Sbjct: 224 AIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAP- 282
Query: 161 ELRAAALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEP-PNSGGGSPCEA 219
+A L A+ R F+G ++ + VN ++D P P S +
Sbjct: 283 ----SAYWLVRATGTNR-GFQGCVQSLAVNGR----------RIDMRPWPLGKALSGADV 327
Query: 220 GEEGEG----GVCLNGGVCSVVD-DQAVCDCSRTGFRGKDC 255
GE G C++GG C+ + D +C C GF+G+ C
Sbjct: 328 GECSSGICDEASCIHGGTCTAIKADSYICLCP-LGFKGRHC 367
>gi|33469929 EGF-like, fibronectin type III and laminin G domains
isoform 1 [Homo sapiens]
Length = 1009
Score = 126 bits (316), Expect = 2e-28
Identities = 151/690 (21%), Positives = 284/690 (41%), Gaps = 133/690 (19%)
Query: 303 MGDQGKSKGKEEYIA--TFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGKS 360
+G G+S ++ I F G Y ++ +N Q+ +ITL F+ +GL+L+ G++
Sbjct: 373 LGKGGESCSEDIVIQYPQFFGHSYVTFEPLKNSYQAF--QITLEFRAEAEDGLLLYCGEN 430
Query: 361 ----ADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIG 416
D+++LA+ ++ N G+G + E K WH V + R+
Sbjct: 431 EHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSET---KIKLGGWHTVMLYRD-------- 479
Query: 417 HAMVNKLHCSVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNN-FM 475
+N L + ++ TG +Q Y+ + Y+GG+PS L + +N F
Sbjct: 480 --GLNGL-----LQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQ 532
Query: 476 GCLKEVVYKNNDVRLELSRLAKQ-------------GDPKMKIHG--VVAFKCENVATLD 520
GC++ + + + L K D IHG A K ++ L
Sbjct: 533 GCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCTAIKADSYICLC 592
Query: 521 PITF-----------------ETPESFISLPKWNAKKTGSISF-----DFRTTEPNGLIL 558
P+ F E+ S+ + P W + +SF FR +G++L
Sbjct: 593 PLGFKGRHCEDAFTLTIPQFRESLRSYAATP-WPLEPQHYLSFMEFEITFRPDSGDGVLL 651
Query: 559 FSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHV 618
+S+ DF +I + GH+ D GSGT +++ + G W+ +
Sbjct: 652 YSYDTGSK------------DFLSINLAGGHVEFRFDCGSGTGVLRSE-DPLTLGNWHEL 698
Query: 619 DFQRDGRSGTISVNTLR-TPYTAPGESEILDLDDELYLGGLP-----ENKAGLVFPTEVW 672
R ++G + V+ + A G + + ++++GG+P + +G++ P
Sbjct: 699 RVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKP---- 754
Query: 673 TALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPCLSNPCKNNGMCR 732
+ G I+ + ++ ++ ++ T+GV + A PC+ PC + G CR
Sbjct: 755 -------FSGSIQKIILNDRTIHVKH----DFTSGVNV---ENAAHPCVRAPCAHGGSCR 800
Query: 733 DGWNRYVCDCSGTGYLGRSCEREAT----VLSYDGSMFMKIQLPVVMHTEA---EDVSLR 785
Y CDC G+ G C++ + + G ++ P ++ + +V +R
Sbjct: 801 PRKEGYDCDCP-LGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMR 859
Query: 786 FRSQRAYGILM---ATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLFAGY 842
F++ G+L+ + R ++D + L L G + + NL G ++
Sbjct: 860 FKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNL---------GSGVASIMVNG 910
Query: 843 NLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNI-------ETGIITER 895
+ ND WH V+ VR G+S K+TVDD A TG+ G +L + E + T R
Sbjct: 911 SFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNR 970
Query: 896 RYLSSVPSNFIGHLQSLTFNGMAYIDLCKN 925
+Y+ + +G + T + +I L ++
Sbjct: 971 QYMRGL----VGCISHFTLSTDYHISLVED 996
Score = 120 bits (301), Expect = 1e-26
Identities = 145/620 (23%), Positives = 245/620 (39%), Gaps = 96/620 (15%)
Query: 719 PCLSNPCKNNGMCRDG--WNRYVCDCSGTGYLGRSCEREATVL--SYDGSMFMKIQLPVV 774
PC C + C + W C C+ G G SC + + + G ++ + P+
Sbjct: 346 PCDETLCSADSFCVNDYTWGGSRCQCT-LGKGGESCSEDIVIQYPQFFGHSYVTFE-PLK 403
Query: 775 MHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKG 834
+A ++L FR++ G+L+ + + L R L R NC + G
Sbjct: 404 NSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQ-----FRFNCGT--G 456
Query: 835 PETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETGIITE 894
+ + + WHTV + R G + L +++ +TGQ G ++++ F
Sbjct: 457 VAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRT-------- 508
Query: 895 RRYLSSVPS------------NFIGHLQSLTFNGM---------------AYIDLCKNGD 927
YL PS F G +QSL NG A + C +G
Sbjct: 509 PLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGI 568
Query: 928 IDYCELNARFGFRNIIAD------PVTFKTKSSYVALA--------TLQAYTS------- 966
D I AD P+ FK + A +L++Y +
Sbjct: 569 CDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEP 628
Query: 967 ------MHLFFQFKTTSLDGLILYNSGDGN-DFIVVELVKGYLHYVFDLGNGANLIKGSS 1019
M F+ S DG++LY+ G+ DF+ + L G++ + FD G+G +++ S
Sbjct: 629 QHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLR--S 686
Query: 1020 NKPLNDNQWHNVMISRDTSNLHTVKIDTK--ITTQITAGARNLDLKSDLYIGGVAKETYK 1077
PL WH + +SR N +++D + + G + +D++IGGV Y
Sbjct: 687 EDPLTLGNWHELRVSRTAKN-GILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPN--YD 743
Query: 1078 SLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGV 1137
+ K + F G + + LN R + D F +G E + C C++ G
Sbjct: 744 DVKKNSGVLKPFSGSIQKIILNDRTIHVKHD--FTSGV---NVENAAHPCVRAPCAHGGS 798
Query: 1138 CLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSK---GGGQITYKWPP-NDRPSTRADRLA 1193
C + +G+ CDC + F G C I G +TY P R S +
Sbjct: 799 CRPRKEGYDCDCPL-GFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVF 857
Query: 1194 IGFSTVQKEAVLV-RVDS-SSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGK 1251
+ F T K+ +L+ R DS D++ L + G + +N+G+ +A N NDG+
Sbjct: 858 MRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGS-GVASIMVNGSFNDGR 916
Query: 1252 YHVVRFTRSGGNATLQVDSW 1271
+H V+ R G + + VD +
Sbjct: 917 WHRVKAVRDGQSGKITVDDY 936
Score = 101 bits (251), Expect = 6e-21
Identities = 91/339 (26%), Positives = 147/339 (43%), Gaps = 22/339 (6%)
Query: 954 SYVALATLQ-AYTSMHLFFQFKTTSLDGLILY---NSGDGNDFIVVELVKGYLHYVFDLG 1009
SYV L+ +Y + + +F+ + DGL+LY N DF+ + +++ L + F+ G
Sbjct: 395 SYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCG 454
Query: 1010 NGANLIKGSSNKPLNDNQWHNVMISRDTSN-LHTVKIDTKITTQITAGARNLDLKSDLYI 1068
G +I + L WH VM+ RD N L + T +T Q + ++ LY+
Sbjct: 455 TGVAIIVSETKIKLGG--WHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYL 512
Query: 1069 GGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGC---EGPST 1125
GG + L + GFQGC+ S+ +NGR D+ L G+ G E S
Sbjct: 513 GGAPSAYW--LVRATGTNRGFQGCVQSLAVNGRRIDMRPWPL---GKALSGADVGECSSG 567
Query: 1126 TCQEDSCSNQGVCLQ-QWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITY---KWPP 1181
C E SC + G C + D + C C + F G C D T I +Y WP
Sbjct: 568 ICDEASCIHGGTCTAIKADSYICLCPL-GFKGRHCEDAFTLTIPQFRESLRSYAATPWPL 626
Query: 1182 NDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIE 1241
+ I F + VL+ +G D+L +++ G + +F+ G+ +
Sbjct: 627 EPQHYLSFMEFEITFRPDSGDGVLL-YSYDTGSKDFLSINLAGGHVEFRFDCGS-GTGVL 684
Query: 1242 ESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAG 1280
S + G +H +R +R+ N LQVD ++E G
Sbjct: 685 RSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEG 723
Score = 90.9 bits (224), Expect = 9e-18
Identities = 108/444 (24%), Positives = 164/444 (36%), Gaps = 113/444 (25%)
Query: 52 SEMSFQLKTR--SARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAE-PATLLADTP 108
S M F++ R S G++LY D G DFL + L GG ++ F C L ++ P
Sbjct: 633 SFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLA-GGHVEFRFD--CGSGTGVLRSEDP 689
Query: 109 VNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLP----PELRA 164
+ G WH +R+ R +N L +D+ + + + + +F+GG+P + +
Sbjct: 690 LTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNS 749
Query: 165 AALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGE 224
LK PF G I+ + +N + VK D + G + A
Sbjct: 750 GVLK----------PFSGSIQKIILNDRTI------HVKHD----FTSGVNVENAAHPCV 789
Query: 225 GGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEIKFGLQCVLPVLLHDNDQGKYCCINT 284
C +GG C + CDC GF G C + I ++
Sbjct: 790 RAPCAHGGSCRPRKEGYDCDCP-LGFEGLHCQKAIIEAIE-------------------- 828
Query: 285 AKPLTEKDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNP-----IQSSSD 339
I F G Y YD NP + S
Sbjct: 829 -------------------------------IPQFIGRSYLTYD---NPDILKRVSGSRS 854
Query: 340 EITLSFKTLQRNGLMLHTGKS-----ADYVNLALKNGAVSLVINLGSGAFEALVEPVNGK 394
+ + FKT ++GL+L G S +D+++L L++GA+ NLGSG + VNG
Sbjct: 855 NVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIM---VNGS 911
Query: 395 FNDNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTISVDGILTTTGYTQEDYTMLGSDDFF 454
FND WH VK R+ + S I+VD TG + L +
Sbjct: 912 FNDGRWHRVKAVRDGQ---------------SGKITVDDYGARTGKSPGMMRQLNINGAL 956
Query: 455 YVGGSPSTADLPGSPVSNNFMGCL 478
YVGG A +GC+
Sbjct: 957 YVGGMKEIALHTNRQYMRGLVGCI 980
Score = 53.9 bits (128), Expect = 1e-06
Identities = 54/221 (24%), Positives = 98/221 (44%), Gaps = 29/221 (13%)
Query: 44 PKWNACCESEMSFQLKTRSARGLVLYF--DDEGFCDFLELILTRGGRLQLSFSIFCAEP- 100
P N+ +++ + + + GL+LY ++ G DF+ L + R L F C
Sbjct: 401 PLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRS---LQFRFNCGTGV 457
Query: 101 ATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPP 160
A ++++T + G WH+V + R N L ++ + + + +T + L++GG P
Sbjct: 458 AIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAP- 516
Query: 161 ELRAAALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEP-PNSGGGSPCEA 219
+A L A+ R F+G ++ + VN ++D P P S +
Sbjct: 517 ----SAYWLVRATGTNR-GFQGCVQSLAVNGR----------RIDMRPWPLGKALSGADV 561
Query: 220 GEEGEG----GVCLNGGVCSVVD-DQAVCDCSRTGFRGKDC 255
GE G C++GG C+ + D +C C GF+G+ C
Sbjct: 562 GECSSGICDEASCIHGGTCTAIKADSYICLCP-LGFKGRHC 601
>gi|38788416 laminin, alpha 1 precursor [Homo sapiens]
Length = 3075
Score = 125 bits (313), Expect = 4e-28
Identities = 180/822 (21%), Positives = 334/822 (40%), Gaps = 141/822 (17%)
Query: 327 YDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGK--SADYVNLALKNGAVSLVINLGSGAF 384
Y + + + ++ +I + F T NGL+L+ G + D++++ L G V ++ +LGSG
Sbjct: 2315 YSVVEKSLPATVTQIIMLFNTFSPNGLLLYLGSYGTKDFLSIELFRGRVKVMTDLGSGPI 2374
Query: 385 EALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTISVDGILTTTGYTQED 444
L + ++N+ W+ + RN +Q V +D T+ T++
Sbjct: 2375 TLLTDR---RYNNGTWYKIAFQRNRKQ--------------GVLAVIDAYNTSNKETKQG 2417
Query: 445 YTMLGSDDF-------FYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAK 497
T S D YVGG P + + + +F+GC+K LE+SR
Sbjct: 2418 ETPGASSDLNRLDKDPIYVGGLPRSRVVRRGVTTKSFVGCIKN---------LEISR--S 2466
Query: 498 QGDPKMKIHGVVAFKCENVATLDPITFET--PESFISLPKWNAKKTGSISFDFRTTEPNG 555
D +GV L+PI + +I LP + F TT +G
Sbjct: 2467 TFDLLRNSYGV-----RKGCLLEPIRSVSFLKGGYIELPPKSLSPESEWLVTFATTNSSG 2521
Query: 556 LILFSHG---KPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKK--- 609
+IL + G + R ++ H V FF++ ++ G++ + ++ G GT KALL
Sbjct: 2522 IILAALGGDVEKRGDREEAH-----VPFFSVMLIGGNIEVHVNPGDGTGLRKALLHAPTG 2576
Query: 610 -VNDGEWYHVDFQRDGRSGTISV---NTLRTPYTAPGESEILDLDDELYLGGLPENKAGL 665
+DG+ + + R+ R T+ + N + ES +++ + LY+GG+PE +
Sbjct: 2577 TCSDGQAHSISLVRNRRIITVQLDENNPVEMKLGTLVESRTINVSN-LYVGGIPEGEG-- 2633
Query: 666 VFPTEVWTALLNY--GYVGCIRDLFIDGQSKDIRQMAEVQST------AGVKPSCSKETA 717
T+LL + GCI++L + + D + +P + +
Sbjct: 2634 -------TSLLTMRRSFHGCIKNLIFNLELLDFNSAVGHEQVDLDTCWLSERPKLAPDAE 2686
Query: 718 -KPCLSNPCKNNGMCR-DGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVM 775
L P C D YV G G + + +L ++ S K
Sbjct: 2687 DSKLLPEPRAFPEQCVVDAALEYV---PGAHQFGLT-QNSHFILPFNQSAVRK------- 2735
Query: 776 HTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGP 835
V L R+ + G++ ++ AD L+L GR+ +L KG
Sbjct: 2736 ---KLSVELSIRTFASSGLIYYMAHQNQADYAVLQLHGGRLHFMFDL---------GKGR 2783
Query: 836 ETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETGIITER 895
+ L+D +WHTV+ + +TVD +++ + GD T L+ +
Sbjct: 2784 TKVSHPALLSDGKWHTVKTDYVKRKGFITVDGRESPMVTVVGDGTMLDVEGL-------- 2835
Query: 896 RYLSSVPSNF----IGHLQ--------SLTFNGMAYIDLCKNGDIDYCELNARFGFRNII 943
YL +PS + IG++ +T N L K+ + +N + +
Sbjct: 2836 FYLGGLPSQYQARKIGNITHSIPACIGDVTVNSK---QLDKDSPVSAFTVNRCYA----V 2888
Query: 944 ADPVTFKTKSSYVALAT--LQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGY 1001
A T+ S Y AL + + +++ +F+T+S +G++L S D I +ELV G
Sbjct: 2889 AQEGTYFDGSGYAALVKEGYKVQSDVNITLEFRTSSQNGVLLGISTAKVDAIGLELVDGK 2948
Query: 1002 LHYVFDLGNGANLIKGS----SNKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQIT-AG 1056
+ +F + NGA I + + L D +WH + ++ + + + +
Sbjct: 2949 V--LFHVNNGAGRITAAYEPKTATVLCDGKWHTLQANKSKHRITLIVDGNAVGAESPHTQ 3006
Query: 1057 ARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDL 1098
+ ++D + +Y+GG + K + ++ F+GCL + L
Sbjct: 3007 STSVDTNNPIYVGGYPAGVKQ---KCLRSQTSFRGCLRKLAL 3045
Score = 118 bits (296), Expect = 4e-26
Identities = 214/1014 (21%), Positives = 389/1014 (38%), Gaps = 215/1014 (21%)
Query: 326 CYDLSQNPIQSSS-DEITLSFKTLQRNGLMLHTGKS--ADYVNLALKNGAVSLVINLGSG 382
C Q I S++ + +TL+ KT + + L+ + G S +D++ + ++ G V+ + +LGSG
Sbjct: 2126 CIRAYQPQISSTNYNTLTLNVKTQEPDNLLFYLGSSTASDFLAVEMRRGRVAFLWDLGSG 2185
Query: 383 AFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTISVDGILTTTGYTQ 442
+ +E + +DN WH + V R IG V ++ + T+
Sbjct: 2186 STR--LEFPDFPIDDNRWHSIHVAR----FGNIGSLSVKEMSSNQKSPTK---TSKSPGT 2236
Query: 443 EDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPK 502
+ + + +VGG + +F GCL E + L + + ++G
Sbjct: 2237 ANVLDVNNSTLMFVGGLGGQIKKSPAVKVTHFKGCLGEAFLNGKSIGL-WNYIEREG--- 2292
Query: 503 MKIHGVVAFKCENVATLDPITFETPESFISLPKWNAKKTGS-ISFDFRTTEPNGLILF-- 559
K G C + + +F S S+ + + T + I F T PNGL+L+
Sbjct: 2293 -KCRG-----CFGSSQNEDPSFHFDGSGYSVVEKSLPATVTQIIMLFNTFSPNGLLLYLG 2346
Query: 560 SHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVD 619
S+G DF +IE+ G + ++ D+GSG I + ++ N+G WY +
Sbjct: 2347 SYGTK--------------DFLSIELFRGRVKVMTDLGSGPITLLTD-RRYNNGTWYKIA 2391
Query: 620 FQRDGRSGTISV-------NTLRTPYTAPGESEILD-LD-DELYLGGLPENKAGLVFPTE 670
FQR+ + G ++V N PG S L+ LD D +Y+GGLP ++
Sbjct: 2392 FQRNRKQGVLAVIDAYNTSNKETKQGETPGASSDLNRLDKDPIYVGGLPRSRV------- 2444
Query: 671 VWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPCLSNPCKNNGM 730
V + +VGCI++L I + D+ ++++ GV+ K CL P ++
Sbjct: 2445 VRRGVTTKSFVGCIKNLEISRSTFDL-----LRNSYGVR--------KGCLLEPIRSVSF 2491
Query: 731 CRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDVSLRFRSQR 790
+ G+ I+LP + + + F +
Sbjct: 2492 LKGGY---------------------------------IELPPKSLSPESEWLVTFATTN 2518
Query: 791 AYGILMATTSRD---SADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLFAGY---NL 844
+ GI++A D D + V L + +N G
Sbjct: 2519 SSGIILAALGGDVEKRGDREEAHVPFFSVMLIGGNIEVHVNPGDGTGLRKALLHAPTGTC 2578
Query: 845 NDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIE--------------TG 890
+D + H++ +VR + + + +D+ + ++ T +E I T
Sbjct: 2579 SDGQAHSISLVRNRRIITVQLDENNPVEMKLG---TLVESRTINVSNLYVGGIPEGEGTS 2635
Query: 891 IITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGF------RNIIA 944
++T RR N I +L+ L FN + D+D C L+ R ++
Sbjct: 2636 LLTMRRSFHGCIKNLIFNLELLDFNSAVGHE---QVDLDTCWLSERPKLAPDAEDSKLLP 2692
Query: 945 DPVTFK--------------------TKSSYVALATLQAYTSMHLFFQ--FKTTSLDGLI 982
+P F T++S+ L Q+ L + +T + GLI
Sbjct: 2693 EPRAFPEQCVVDAALEYVPGAHQFGLTQNSHFILPFNQSAVRKKLSVELSIRTFASSGLI 2752
Query: 983 LYNSGDGN-DFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLH 1041
Y + D+ V++L G LH++FDLG G K S L+D +WH V
Sbjct: 2753 YYMAHQNQADYAVLQLHGGRLHFMFDLGKGRT--KVSHPALLSDGKWHTVKTDY-VKRKG 2809
Query: 1042 TVKIDTKITTQIT--AGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLN 1099
+ +D + + +T LD++ Y+GG+ + Y++ K+ + C+ V +N
Sbjct: 2810 FITVDGRESPMVTVVGDGTMLDVEGLFYLGGLPSQ-YQA-RKIGNITHSIPACIGDVTVN 2867
Query: 1100 GRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLC 1159
+ Q+++ + T C + G
Sbjct: 2868 SK-------------QLDKDSPVSAFTVNR-------------------CYAVAQEGTYF 2895
Query: 1160 NDPGTTYIFSKGGGQITYKWPPNDRPSTRAD-RLAIGFSTVQKEAVLVRVDSSSGLGDYL 1218
+ G + +G YK ++D + + F T + VL+ + S+ D +
Sbjct: 2896 DGSGYAALVKEG-----YK--------VQSDVNITLEFRTSSQNGVLLGI--STAKVDAI 2940
Query: 1219 ELHIHQGKIGVKFNVGTDDI--AIEESNA-IINDGKYHVVRFTRSGGNATLQVD 1269
L + GK+ N G I A E A ++ DGK+H ++ +S TL VD
Sbjct: 2941 GLELVDGKVLFHVNNGAGRITAAYEPKTATVLCDGKWHTLQANKSKHRITLIVD 2994
Score = 64.7 bits (156), Expect = 7e-10
Identities = 76/347 (21%), Positives = 138/347 (39%), Gaps = 54/347 (15%)
Query: 322 SEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTG--KSADYVNLALKNGAVSLVINL 379
+ +F +Q+ ++ + LS +T +GL+ + ADY L L G + + +L
Sbjct: 2721 NSHFILPFNQSAVRKKLS-VELSIRTFASSGLIYYMAHQNQADYAVLQLHGGRLHFMFDL 2779
Query: 380 GSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTISVDGILTTTG 439
G G + + +D WH VK R+ I+VDG +
Sbjct: 2780 GKGRTKVSHPAL---LSDGKWHTVKTDYVKRKGF---------------ITVDGRESPMV 2821
Query: 440 YTQEDYTMLGSDDFFYVGGSPSTADLPG-SPVSNNFMGCLKEVVYKNNDVRLELSRLAKQ 498
D TML + FY+GG PS ++++ C+ +V +KQ
Sbjct: 2822 TVVGDGTMLDVEGLFYLGGLPSQYQARKIGNITHSIPACIGDVTVN-----------SKQ 2870
Query: 499 GDPKMKIHGVVAFKCENVATLDPITFETPESFISLPK--WNAKKTGSISFDFRTTEPNGL 556
D + +C VA T+ + +L K + + +I+ +FRT+ NG+
Sbjct: 2871 LDKDSPVSAFTVNRCYAVA--QEGTYFDGSGYAALVKEGYKVQSDVNITLEFRTSSQNGV 2928
Query: 557 ILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVN---DG 613
+L KVD +E++DG + ++ G+G I K DG
Sbjct: 2929 LL-------------GISTAKVDAIGLELVDGKVLFHVNNGAGRITAAYEPKTATVLCDG 2975
Query: 614 EWYHVDFQRDGRSGTISVNTLRTPYTAP-GESEILDLDDELYLGGLP 659
+W+ + + T+ V+ +P +S +D ++ +Y+GG P
Sbjct: 2976 KWHTLQANKSKHRITLIVDGNAVGAESPHTQSTSVDTNNPIYVGGYP 3022
Score = 53.9 bits (128), Expect = 1e-06
Identities = 52/199 (26%), Positives = 82/199 (41%), Gaps = 27/199 (13%)
Query: 319 FKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGKS-ADYVNLALKNGAVSLVI 377
F GS Y +QS + ITL F+T +NG++L + D + L L +G V +
Sbjct: 2895 FDGSGYAALVKEGYKVQSDVN-ITLEFRTSSQNGVLLGISTAKVDAIGLELVDGKVLFHV 2953
Query: 378 NLGSGAFEALVEPVNGK-FNDNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTISVDGILT 436
N G+G A EP D WH ++ NK +T+ VDG
Sbjct: 2954 NNGAGRITAAYEPKTATVLCDGKWHTLQA---------------NKSKHRITLIVDGNAV 2998
Query: 437 TTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEV-VYKNNDVR-LELSR 494
T + +++ YVGG P+ +F GCL+++ + K+ V+ + SR
Sbjct: 2999 GAESPHTQSTSVDTNNPIYVGGYPAGVKQKCLRSQTSFRGCLRKLALIKSPQVQSFDFSR 3058
Query: 495 LAKQGDPKMKIHGVVAFKC 513
++HGV C
Sbjct: 3059 -------AFELHGVFLHSC 3070
Score = 43.9 bits (102), Expect = 0.001
Identities = 39/146 (26%), Positives = 63/146 (43%), Gaps = 18/146 (12%)
Query: 54 MSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIF-----CAEPATLLADTP 108
+ ++T ++ GL+ Y + D+ L L GGRL F + + PA L
Sbjct: 2739 VELSIRTFASSGLIYYMAHQNQADYAVLQL-HGGRLHFMFDLGKGRTKVSHPALL----- 2792
Query: 109 VNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALK 168
+DG WH+V+ R + +D E+ V V + V ++GGLP + +A +
Sbjct: 2793 -SDGKWHTVKTDYVKRKGFITVDGRESPMVTVVGDGTMLDVEGLFYLGGLPSQYQARKIG 2851
Query: 169 LTLASVREREPFKGWIRDVRVNSSQV 194
S+ I DV VNS Q+
Sbjct: 2852 NITHSI------PACIGDVTVNSKQL 2871
Score = 42.4 bits (98), Expect = 0.004
Identities = 33/108 (30%), Positives = 48/108 (44%), Gaps = 10/108 (9%)
Query: 60 TRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRI 119
T S GL+LY G DFL + L RG R+++ + P TLL D N+G W+ +
Sbjct: 2335 TFSPNGLLLYLGSYGTKDFLSIELFRG-RVKVMTDLGSG-PITLLTDRRYNNGTWYKIAF 2392
Query: 120 RRQFRNTTLFI------DQVEAKWVEVKSKRRDMTVF--SGLFVGGLP 159
+R + L + E K E D+ ++VGGLP
Sbjct: 2393 QRNRKQGVLAVIDAYNTSNKETKQGETPGASSDLNRLDKDPIYVGGLP 2440
Score = 38.5 bits (88), Expect = 0.051
Identities = 32/160 (20%), Positives = 69/160 (43%), Gaps = 18/160 (11%)
Query: 44 PKWNACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATL 103
P+ ++ + ++ +KT+ L+ Y DFL + + RG R+ + +
Sbjct: 2132 PQISSTNYNTLTLNVKTQEPDNLLFYLGSSTASDFLAVEMRRG-RVAFLWDLGSGSTRLE 2190
Query: 104 LADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRR--------DMTVFSGLFV 155
D P++D WHS+ + R +L + ++ + + D+ + +FV
Sbjct: 2191 FPDFPIDDNRWHSIHVARFGNIGSLSVKEMSSNQKSPTKTSKSPGTANVLDVNNSTLMFV 2250
Query: 156 GGLPPEL-RAAALKLTLASVREREPFKGWIRDVRVNSSQV 194
GGL ++ ++ A+K+T FKG + + +N +
Sbjct: 2251 GGLGGQIKKSPAVKVT--------HFKGCLGEAFLNGKSI 2282
Score = 36.6 bits (83), Expect = 0.19
Identities = 20/93 (21%), Positives = 46/93 (49%), Gaps = 1/93 (1%)
Query: 1186 STRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNA 1245
ST + L + T + + +L + SS+ D+L + + +G++ +++G+ +E +
Sbjct: 2136 STNYNTLTLNVKTQEPDNLLFYLGSSTA-SDFLAVEMRRGRVAFLWDLGSGSTRLEFPDF 2194
Query: 1246 IINDGKYHVVRFTRSGGNATLQVDSWPVIERYP 1278
I+D ++H + R G +L V ++ P
Sbjct: 2195 PIDDNRWHSIHVARFGNIGSLSVKEMSSNQKSP 2227
>gi|148664242 cell recognition protein CASPR4 isoform 2 [Homo sapiens]
Length = 1235
Score = 114 bits (286), Expect = 6e-25
Identities = 95/343 (27%), Positives = 155/343 (45%), Gaps = 39/343 (11%)
Query: 948 TFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKG-YLHYVF 1006
+F T++SY+ T S + F FKTT+ G+ L N G DFI +EL + + F
Sbjct: 723 SFDTEASYLHFPTFHGELSADVSFFFKTTASSGVFLENLGIA-DFIRIELRSPTVVTFSF 781
Query: 1007 DLGNGANLIKGSSNKPLNDNQWHNVMISRDT--SNLHTVKIDTKITTQITAGARNLDLKS 1064
D+GNG I S NDNQWH+V + R+ ++L ++ K G L L S
Sbjct: 782 DVGNGPFEISVQSPTHFNDNQWHHVRVERNMKEASLQVDQLTPKTQPAPADGHVLLQLNS 841
Query: 1065 DLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPS 1124
L++GG A + GF GC+ S+ LNG DL A +++ GC G
Sbjct: 842 QLFVGGTATR-----------QRGFLGCIRSLQLNGMTLDLEERAQV-TPEVQPGCRGHC 889
Query: 1125 TTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDR 1184
++ + C N G C ++ GF CDC+ ++++GP C++ + Y S G + Y + N
Sbjct: 890 SSYGK-LCRNGGKCRERPIGFFCDCTFSAYTGPFCSNEISAYFGS--GSSVIYNFQENYL 946
Query: 1185 PSTRA---------------DRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQG---K 1226
S + + + F T + ++L+ V SS +YL + I + +
Sbjct: 947 LSKNSSSHAASFHGDMKLSREMIKFSFRTTRTPSLLLFV--SSFYKEYLSVIIAKNGSLQ 1004
Query: 1227 IGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVD 1269
I K N + + + DG+ H + R G +++D
Sbjct: 1005 IRYKLNKYQEPDVVNFDFKNMADGQLHHIMINREEGVVFIEID 1047
Score = 108 bits (270), Expect = 4e-23
Identities = 114/455 (25%), Positives = 189/455 (41%), Gaps = 93/455 (20%)
Query: 752 CEREATVLSYDGSMFMKIQLPVVMHTEAEDV-SLRFRSQRAYGILMATTSRDSADTLRLE 810
C + V+ DG + + + +D+ SL+F++ ++ GIL+ + D + L+
Sbjct: 152 CAYRSEVVDLDGKSSLLYRFDQKSLSPIKDIISLKFKTMQSDGILLHREG-PNGDHITLQ 210
Query: 811 LDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQA 870
L R+ L +N ++ S+ TL G L+D WH+V + R GK + TVD+ +
Sbjct: 211 LRRARLFLLINSGEAKLPSTSTLVNLTL--GSLLDDQHWHSVLIQRLGKQVNFTVDEHRH 268
Query: 871 MTGQMAGDHTRLEFHNIETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDY 930
H R EF+ L +L + G
Sbjct: 269 HF------HARGEFN-----------------------LMNLDYEG-------------- 285
Query: 931 CELNARFGFRNIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGN 990
N F + PVTF + SY+AL + FQF+T + GL+L++
Sbjct: 286 ---NVSFSCSQPQSMPVTFLSSRSYLALPDFSGEEEVSATFQFRTWNKAGLLLFSE---- 338
Query: 991 DFIVVELVKG-YLHYVFDLGNGANLIKG-------SSNKPLNDNQWHNVMISRDTSNLHT 1042
++L+ G L ++ D +NL + ++ LND QWH+V +S ++L +
Sbjct: 339 ----LQLISGGILLFLSDGKLKSNLYQPGKLPSDITAGVELNDGQWHSVSLSAKKNHL-S 393
Query: 1043 VKIDTKITTQITA-GARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGR 1101
V +D ++ + G + Y GG +++ S K GFQGC+ + ++G+
Sbjct: 394 VAVDGQMASAAPLLGPEQIYSGGTYYFGGCPDKSFGS--KCKSPLGGFQGCMRLISISGK 451
Query: 1102 LPDLISDAL-----FCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSG 1156
+ DLIS F + QI+ C G S C + C + G C Q W F C+C+ T + G
Sbjct: 452 VVDLISVQQGSLGNFSDLQID-SC-GISDRCLPNYCEHGGECSQSWSTFHCNCTNTGYRG 509
Query: 1157 PLC----------------NDPGTTYIFSKGGGQI 1175
C N G YI S G G +
Sbjct: 510 ATCHNSIYEQSCEAYKHRGNTSGFYYIDSDGSGPL 544
Score = 97.4 bits (241), Expect = 9e-20
Identities = 90/394 (22%), Positives = 165/394 (41%), Gaps = 69/394 (17%)
Query: 504 KIHGVVAFK-----CENVATL-DPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLI 557
++H A+K C+ + + +F+T S++ P ++ + + +SF F+TT +G+
Sbjct: 698 RLHSEAAYKLGPLLCQGDRSFWNSASFDTEASYLHFPTFHGELSADVSFFFKTTASSGVF 757
Query: 558 LFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLL-LDMGSGTIKIKALLKK-VNDGEW 615
L + G DF IE+ + D+G+G +I ND +W
Sbjct: 758 LENLGI--------------ADFIRIELRSPTVVTFSFDVGNGPFEISVQSPTHFNDNQW 803
Query: 616 YHVDFQRDGRSGTISVNTLRTPYTAPGESE---ILDLDDELYLGGLPENKAGLVFPTEVW 672
+HV +R+ + ++ V+ L TP T P ++ +L L+ +L++GG
Sbjct: 804 HHVRVERNMKEASLQVDQL-TPKTQPAPADGHVLLQLNSQLFVGG--------------- 847
Query: 673 TALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPCLSNPCKNNGMCR 732
TA G++GCIR L ++G + D+ + A+V T V+P C + C+N G CR
Sbjct: 848 TATRQRGFLGCIRSLQLNGMTLDLEERAQV--TPEVQPGCRGHCSS--YGKLCRNGGKCR 903
Query: 733 DGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFM----------------KIQLPVVMH 776
+ + CDC+ + Y G C E + GS + M
Sbjct: 904 ERPIGFFCDCTFSAYTGPFCSNEISAYFGSGSSVIYNFQENYLLSKNSSSHAASFHGDMK 963
Query: 777 TEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPE 836
E + FR+ R +L+ +S + G ++ IR N + P+
Sbjct: 964 LSREMIKFSFRTTRTPSLLLFVSSFYKEYLSVIIAKNGSLQ-------IRYKLNKYQEPD 1016
Query: 837 TL-FAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQ 869
+ F N+ D + H + + R + + +DD +
Sbjct: 1017 VVNFDFKNMADGQLHHIMINREEGVVFIEIDDNR 1050
Score = 79.3 bits (194), Expect = 3e-14
Identities = 63/262 (24%), Positives = 114/262 (43%), Gaps = 50/262 (19%)
Query: 507 GVVAFKCENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRH 566
G V+F C ++ P+TF + S+++LP ++ ++ S +F FRT GL+LFS
Sbjct: 285 GNVSFSCSQPQSM-PVTFLSSRSYLALPDFSGEEEVSATFQFRTWNKAGLLLFSE----- 338
Query: 567 QKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKK-------------VNDG 613
++++ G + L L G K+K+ L + +NDG
Sbjct: 339 ----------------LQLISGGILLFLSDG----KLKSNLYQPGKLPSDITAGVELNDG 378
Query: 614 EWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWT 673
+W+ V +++V+ E + Y GG P+ G + +
Sbjct: 379 QWHSVSLSAKKNHLSVAVDGQMASAAPLLGPEQIYSGGTYYFGGCPDKSFGSKCKSPLG- 437
Query: 674 ALLNYGYVGCIRDLFIDGQSKDIR--QMAEVQSTAGVK-PSCSKETAKPCLSNPCKNNGM 730
G+ GC+R + I G+ D+ Q + + + ++ SC + CL N C++ G
Sbjct: 438 -----GFQGCMRLISISGKVVDLISVQQGSLGNFSDLQIDSCG--ISDRCLPNYCEHGGE 490
Query: 731 CRDGWNRYVCDCSGTGYLGRSC 752
C W+ + C+C+ TGY G +C
Sbjct: 491 CSQSWSTFHCNCTNTGYRGATC 512
Score = 68.6 bits (166), Expect = 5e-11
Identities = 56/225 (24%), Positives = 93/225 (41%), Gaps = 26/225 (11%)
Query: 37 EGQWTRFPKWNACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIF 96
E + FP ++ +++SF KT ++ G+ L ++ G DF+ + L + SF +
Sbjct: 727 EASYLHFPTFHGELSADVSFFFKTTASSGVFL--ENLGIADFIRIELRSPTVVTFSFDVG 784
Query: 97 CAE-PATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVF-SGLF 154
++ + T ND WH VR+ R + +L +DQ+ K + + S LF
Sbjct: 785 NGPFEISVQSPTHFNDNQWHHVRVERNMKEASLQVDQLTPKTQPAPADGHVLLQLNSQLF 844
Query: 155 VGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGG 214
VGG R F G IR +++N + + +V + +P
Sbjct: 845 VGGTATRQRG---------------FLGCIRSLQLNGMTLDLEERAQVTPEVQPG----- 884
Query: 215 SPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEI 259
C G +C NGG C CDC+ + + G CS EI
Sbjct: 885 --CRGHCSSYGKLCRNGGKCRERPIGFFCDCTFSAYTGPFCSNEI 927
Score = 62.0 bits (149), Expect = 4e-09
Identities = 91/382 (23%), Positives = 152/382 (39%), Gaps = 78/382 (20%)
Query: 781 DVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLF- 839
DVS F++ + G+ + AD +R+EL + V + + + GP +
Sbjct: 743 DVSFFFKTTASSGVFLENLG--IADFIRIELRSPTV--------VTFSFDVGNGPFEISV 792
Query: 840 -AGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGD-HTRLEFHN--IETGIITER 895
+ + NDN+WH VRV R K L VD T D H L+ ++ G T +
Sbjct: 793 QSPTHFNDNQWHHVRVERNMKEASLQVDQLTPKTQPAPADGHVLLQLNSQLFVGGTATRQ 852
Query: 896 RYLSSVPSNFIGHLQSLTFNGM-----------------------AYIDLCKNGDI---- 928
R F+G ++SL NGM +Y LC+NG
Sbjct: 853 R-------GFLGCIRSLQLNGMTLDLEERAQVTPEVQPGCRGHCSSYGKLCRNGGKCRER 905
Query: 929 ---------------DYC--ELNARFG-----FRNIIADPVTFKTKSSYVALATLQAYTS 966
+C E++A FG N + + K SS+ A S
Sbjct: 906 PIGFFCDCTFSAYTGPFCSNEISAYFGSGSSVIYNFQENYLLSKNSSSHAASFHGDMKLS 965
Query: 967 MHLF-FQFKTTSLDGLILYNSGDGNDFIVVELVK-GYLHYVFDLGNGANL-IKGSSNKPL 1023
+ F F+TT L+L+ S +++ V + K G L + L + K +
Sbjct: 966 REMIKFSFRTTRTPSLLLFVSSFYKEYLSVIIAKNGSLQIRYKLNKYQEPDVVNFDFKNM 1025
Query: 1024 NDNQWHNVMISRDTSNLHTVKIDTKITTQI--TAGARNLDLKSDLYIGGVAKETYKSLPK 1081
D Q H++MI+R+ + ++ID Q+ ++G +KS L +G + + +
Sbjct: 1026 ADGQLHHIMINRE-EGVVFIEIDDNRRRQVHLSSGTEFSAVKS-LVLGRILEHSDVDQDT 1083
Query: 1082 LVHAKEGFQGCLASVDLNGRLP 1103
+ +GF GCL++V L+ P
Sbjct: 1084 ALAGAQGFTGCLSAVQLSHVAP 1105
Score = 53.1 bits (126), Expect = 2e-06
Identities = 51/214 (23%), Positives = 92/214 (42%), Gaps = 20/214 (9%)
Query: 51 ESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVN 110
E +FQ +T + GL+L+ + + + L L+ G+L+ + P+ + A +N
Sbjct: 318 EVSATFQFRTWNKAGLLLFSELQLISGGILLFLS-DGKLKSNLYQPGKLPSDITAGVELN 376
Query: 111 DGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSG--LFVGGLPPELRAAALK 168
DG WHSV + + + ++ +D A + + ++SG + GG P + + K
Sbjct: 377 DGQWHSVSLSAKKNHLSVAVDGQMASAAPLLGPEQ---IYSGGTYYFGGCPDKSFGSKCK 433
Query: 169 LTLASVREREPFKGWIRDVRVNSSQV--LPVDSGEV-KLDDEPPNSGGGSPCEAGEEGEG 225
L F+G +R + ++ V + V G + D +S C +
Sbjct: 434 SPLGG------FQGCMRLISISGKVVDLISVQQGSLGNFSDLQIDS-----CGISDRCLP 482
Query: 226 GVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEI 259
C +GG CS C+C+ TG+RG C I
Sbjct: 483 NYCEHGGECSQSWSTFHCNCTNTGYRGATCHNSI 516
Score = 52.8 bits (125), Expect = 3e-06
Identities = 41/162 (25%), Positives = 76/162 (46%), Gaps = 28/162 (17%)
Query: 338 SDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAV-SLVINLGSGAFEALVEPVNGKFN 396
S +++ FKT +G+ L AD++ + L++ V + ++G+G FE V+ FN
Sbjct: 741 SADVSFFFKTTASSGVFLENLGIADFIRIELRSPTVVTFSFDVGNGPFEISVQSPT-HFN 799
Query: 397 DNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTISVDGILTTTGYTQED-YTMLGSDDFFY 455
DN WH V+V RN+++ S + VD + T D + +L + +
Sbjct: 800 DNQWHHVRVERNMKEAS---------------LQVDQLTPKTQPAPADGHVLLQLNSQLF 844
Query: 456 VGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAK 497
VGG+ + F+GC++ + + N + L+L A+
Sbjct: 845 VGGTATR--------QRGFLGCIRSL--QLNGMTLDLEERAQ 876
Score = 49.7 bits (117), Expect = 2e-05
Identities = 28/97 (28%), Positives = 44/97 (45%), Gaps = 5/97 (5%)
Query: 316 IATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLH-TGKSADYVNLALKNGAVS 374
+ G Y Q + D I+L FKT+Q +G++LH G + D++ L L+ +
Sbjct: 158 VVDLDGKSSLLYRFDQKSLSPIKDIISLKFKTMQSDGILLHREGPNGDHITLQLRRARLF 217
Query: 375 LVINLGSGAFEALVEPVN----GKFNDNAWHDVKVTR 407
L+IN G + VN +D WH V + R
Sbjct: 218 LLINSGEAKLPSTSTLVNLTLGSLLDDQHWHSVLIQR 254
Score = 37.0 bits (84), Expect = 0.15
Identities = 27/115 (23%), Positives = 50/115 (43%), Gaps = 19/115 (16%)
Query: 544 ISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKI 603
IS F+T + +G++L G D +++ L+LL++ G +
Sbjct: 183 ISLKFKTMQSDGILLHREGP-------------NGDHITLQLRRARLFLLINSGEAKLPS 229
Query: 604 KALLKKV------NDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDE 652
+ L + +D W+ V QR G+ +V+ R + A GE +++LD E
Sbjct: 230 TSTLVNLTLGSLLDDQHWHSVLIQRLGKQVNFTVDEHRHHFHARGEFNLMNLDYE 284
>gi|239743797 PREDICTED: similar to cell recognition molecule CASPR3
[Homo sapiens]
Length = 944
Score = 114 bits (285), Expect = 7e-25
Identities = 107/403 (26%), Positives = 181/403 (44%), Gaps = 50/403 (12%)
Query: 948 TFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVEL-VKGYLHYVF 1006
+F T++SY+ + + F FKTT G+ + N G DFI +EL + + F
Sbjct: 529 SFNTETSYLHFPAFHGELTADVCFFFKTTVSSGVFMENLGI-TDFIRIELRAPTEVTFSF 587
Query: 1007 DLGNGANLIKGSSNKPLNDNQWHNVMISRDT--SNLHTVKIDTKITTQITAGARNLDLKS 1064
D+GNG + S P NDNQWH+V R+ ++L ++ K+ G L L S
Sbjct: 588 DVGNGPCEVTVQSPTPFNDNQWHHVRAERNVKGASLQVDQLPQKMQPAPADGHVRLQLNS 647
Query: 1065 DLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPS 1124
L+IGG A + GF GC+ S+ LNG DL A G +E GC G
Sbjct: 648 QLFIGGTATR-----------QRGFLGCIRSLQLNGVALDLEERATVMPG-VEPGCAGHC 695
Query: 1125 TTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPN-- 1182
+T C N G C ++ G +CDC+ +++ GP C++ + Y + G +TY + +
Sbjct: 696 ST-YGHLCRNGGRCREKRRGVTCDCAFSAYDGPFCSNEISAYFAT--GSSMTYHFQEHYT 752
Query: 1183 --------------DRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHI-HQGKI 1227
D TR + + + F T + ++L+ V SS +YL + + + G +
Sbjct: 753 LSENSSSLVSSLHRDVTLTR-EMITLSFRTTRTPSLLLYV--SSFYEEYLSVILANNGSL 809
Query: 1228 GVKFNV----GTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNND 1283
+++ + D + N + DG+ H V+ R A + V+ ++ ++
Sbjct: 810 QIRYKLDRHQNPDAFTFDFKN--MADGQLHQVKINRE--EAVVMVEVNQSAKKQVILSSG 865
Query: 1284 NERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQATIIIGG 1326
E A+ + LGR +D+G L + + + +IGG
Sbjct: 866 TEFNAVKSLILGKVLGR---SGPVDEGEPLVNADRRDSAVIGG 905
Score = 90.1 bits (222), Expect = 1e-17
Identities = 82/355 (23%), Positives = 150/355 (42%), Gaps = 61/355 (17%)
Query: 523 TFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFA 582
+F T S++ P ++ + T + F F+TT +G+ + + G DF
Sbjct: 529 SFNTETSYLHFPAFHGELTADVCFFFKTTVSSGVFMENLGI--------------TDFIR 574
Query: 583 IEM-LDGHLYLLLDMGSGTIKIKALLKK-VNDGEWYHVDFQRDGRSGTISVNTL-RTPYT 639
IE+ + D+G+G ++ ND +W+HV +R+ + ++ V+ L +
Sbjct: 575 IELRAPTEVTFSFDVGNGPCEVTVQSPTPFNDNQWHHVRAERNVKGASLQVDQLPQKMQP 634
Query: 640 APGESEI-LDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQ 698
AP + + L L+ +L++GG TA G++GCIR L ++G + D+ +
Sbjct: 635 APADGHVRLQLNSQLFIGG---------------TATRQRGFLGCIRSLQLNGVALDLEE 679
Query: 699 MAEVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATV 758
A V GV+P C+ + + C+N G CR+ CDC+ + Y G C E +
Sbjct: 680 RATVMP--GVEPGCAGHCST--YGHLCRNGGRCREKRRGVTCDCAFSAYDGPFCSNEISA 735
Query: 759 LSYDGSMFM------------KIQLPVVMHTEA----EDVSLRFRSQRAYGILMATTSRD 802
GS L +H + E ++L FR+ R +L+ +S
Sbjct: 736 YFATGSSMTYHFQEHYTLSENSSSLVSSLHRDVTLTREMITLSFRTTRTPSLLLYVSSFY 795
Query: 803 SADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETL-FAGYNLNDNEWHTVRVVR 856
+ + G +++ LD + P+ F N+ D + H V++ R
Sbjct: 796 EEYLSVILANNGSLQIRYKLD-------RHQNPDAFTFDFKNMADGQLHQVKINR 843
Score = 67.8 bits (164), Expect = 8e-11
Identities = 58/225 (25%), Positives = 95/225 (42%), Gaps = 26/225 (11%)
Query: 37 EGQWTRFPKWNACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIF 96
E + FP ++ +++ F KT + G+ + ++ G DF+ + L + SF +
Sbjct: 533 ETSYLHFPAFHGELTADVCFFFKTTVSSGV--FMENLGITDFIRIELRAPTEVTFSFDVG 590
Query: 97 CAE-PATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRR-DMTVFSGLF 154
T+ + TP ND WH VR R + +L +DQ+ K + + + S LF
Sbjct: 591 NGPCEVTVQSPTPFNDNQWHHVRAERNVKGASLQVDQLPQKMQPAPADGHVRLQLNSQLF 650
Query: 155 VGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGG 214
+GG + R+R F G IR +++N + + V EP +G
Sbjct: 651 IGG--------------TATRQR-GFLGCIRSLQLNGVALDLEERATVMPGVEPGCAGHC 695
Query: 215 SPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEI 259
S G +C NGG C CDC+ + + G CS EI
Sbjct: 696 ST-------YGHLCRNGGRCREKRRGVTCDCAFSAYDGPFCSNEI 733
Score = 50.1 bits (118), Expect = 2e-05
Identities = 26/76 (34%), Positives = 36/76 (47%), Gaps = 3/76 (3%)
Query: 1088 GFQGCLASVDLNGRLPDLI---SDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDG 1144
GFQGCL + + + D I AL ++ G + C C + G C Q WD
Sbjct: 202 GFQGCLRLITIGDKAVDPILVQQGALGSFRDLQIDSCGITDRCLPSYCEHGGECSQSWDT 261
Query: 1145 FSCDCSMTSFSGPLCN 1160
FSCDC T ++G C+
Sbjct: 262 FSCDCLGTGYTGETCH 277
Score = 48.1 bits (113), Expect = 6e-05
Identities = 24/76 (31%), Positives = 40/76 (52%), Gaps = 3/76 (3%)
Query: 679 GYVGCIRDLFIDGQSKD--IRQMAEVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWN 736
G+ GC+R + I ++ D + Q + S ++ T + CL + C++ G C W+
Sbjct: 202 GFQGCLRLITIGDKAVDPILVQQGALGSFRDLQIDSCGITDR-CLPSYCEHGGECSQSWD 260
Query: 737 RYVCDCSGTGYLGRSC 752
+ CDC GTGY G +C
Sbjct: 261 TFSCDCLGTGYTGETC 276
Score = 47.4 bits (111), Expect = 1e-04
Identities = 78/317 (24%), Positives = 115/317 (36%), Gaps = 82/317 (25%)
Query: 781 DVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLFA 840
DV F++ + G+ M D +R+EL A ++T + D C + T F
Sbjct: 549 DVCFFFKTTVSSGVFMENLG--ITDFIRIELRAP-TEVTFSFDVGNGPCEVTVQSPTPF- 604
Query: 841 GYNLNDNEWHTVRVVRRGKSLKLTVDD-QQAMTGQMAGDHTRLEFHN--IETGIITERRY 897
NDN+WH VR R K L VD Q M A H RL+ ++ G T +R
Sbjct: 605 ----NDNQWHHVRAERNVKGASLQVDQLPQKMQPAPADGHVRLQLNSQLFIGGTATRQR- 659
Query: 898 LSSVPSNFIGHLQSLTFNGMA-----------------------YIDLCKNGDIDYCELN 934
F+G ++SL NG+A Y LC+NG
Sbjct: 660 ------GFLGCIRSLQLNGVALDLEERATVMPGVEPGCAGHCSTYGHLCRNGG------R 707
Query: 935 ARFGFRNIIAD--------PVTFKTKSSYVALATLQAY----------------TSMH-- 968
R R + D P S+Y A + Y +S+H
Sbjct: 708 CREKRRGVTCDCAFSAYDGPFCSNEISAYFATGSSMTYHFQEHYTLSENSSSLVSSLHRD 767
Query: 969 -------LFFQFKTTSLDGLILYNSGDGNDFIVVELV-KGYLHYVFDLGNGANLIKGSSN 1020
+ F+TT L+LY S +++ V L G L + L N + +
Sbjct: 768 VTLTREMITLSFRTTRTPSLLLYVSSFYEEYLSVILANNGSLQIRYKLDRHQNPDAFTFD 827
Query: 1021 -KPLNDNQWHNVMISRD 1036
K + D Q H V I+R+
Sbjct: 828 FKNMADGQLHQVKINRE 844
Score = 38.9 bits (89), Expect = 0.039
Identities = 51/210 (24%), Positives = 84/210 (40%), Gaps = 34/210 (16%)
Query: 206 DEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEIKFGLQC 265
+E S GGS +A + C G + +D Q C+C R + S I +
Sbjct: 439 NETHTSWGGSLPDAQK------CTCGLEGNCIDSQYYCNCDAG--RNEWTSDTIVLSQKE 490
Query: 266 VLPVLLHDNDQGKYCCINTAKPLTEKDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYF 325
LPV + + +P +E D + L L GD+ +F S F
Sbjct: 491 HLPVT-------QIVMTDAGQPHSEADYTLGPL--LCRGDK-----------SFWNSASF 530
Query: 326 CYDLSQNPIQSSSDEITLS----FKTLQRNGLMLHTGKSADYVNLALKNGA-VSLVINLG 380
+ S + E+T FKT +G+ + D++ + L+ V+ ++G
Sbjct: 531 NTETSYLHFPAFHGELTADVCFFFKTTVSSGVFMENLGITDFIRIELRAPTEVTFSFDVG 590
Query: 381 SGAFEALVEPVNGKFNDNAWHDVKVTRNLR 410
+G E V+ FNDN WH V+ RN++
Sbjct: 591 NGPCEVTVQSPT-PFNDNQWHHVRAERNVK 619
Score = 32.3 bits (72), Expect = 3.7
Identities = 13/32 (40%), Positives = 17/32 (53%)
Query: 228 CLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEI 259
C +GG CS D CDC TG+ G+ C +
Sbjct: 249 CEHGGECSQSWDTFSCDCLGTGYTGETCHSSL 280
>gi|119466532 laminin alpha 2 subunit isoform b precursor [Homo
sapiens]
Length = 3118
Score = 105 bits (262), Expect = 3e-22
Identities = 164/749 (21%), Positives = 282/749 (37%), Gaps = 137/749 (18%)
Query: 578 VDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTP 637
+DF AIEM G + L D+GSG +++ ++D WY + R GR+GTISV L P
Sbjct: 2192 IDFLAIEMRKGKVSFLWDVGSGVGRVEYPDLTIDDSYWYRIVASRTGRNGTISVRALDGP 2251
Query: 638 Y----------TAPGESEILDLDDE--LYLGGLPENKAGLVFPTEVWTALLNYGYVGCIR 685
T+P ILD+D L++GGL K V T + GC+
Sbjct: 2252 KASIVPSTHHSTSPPGYTILDVDANAMLFVGGLT-GKLKKADAVRVIT------FTGCMG 2304
Query: 686 DLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGT 745
+ + D + + E + K C +P V D GT
Sbjct: 2305 ETYFDNKPIGLWNFREKEGDC-----------KGCTVSP-------------QVEDSEGT 2340
Query: 746 GYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSAD 805
+ +DG + + P+ + V +FR+ + +LM +RD D
Sbjct: 2341 -------------IQFDGEGYALVSRPIRWYPNISTVMFKFRTFSSSALLMYLATRDLRD 2387
Query: 806 TLRLELDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTV 865
+ +EL G +K++ +L G ++ + N ND +W + + R K +++
Sbjct: 2388 FMSVELTDGHIKVSYDL---------GSGMASVVSNQNHNDGKWKSFTLSRIQKQANISI 2438
Query: 866 DD-----QQAMTGQMAGDHTRLEFHNIET----GIITERRYLSSVP-SNFIGHLQSLTFN 915
D ++ + +G++ L+ + G+ T R V + G L+ + +
Sbjct: 2439 VDIDTNQEENIATSSSGNNFGLDLKADDKIYFGGLPTLRNLRPEVNLKKYSGCLKDIEIS 2498
Query: 916 GMAYIDLCKNGDIDYCELNARFGFRNIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKT 975
Y L DY + N+ V+F K +V L+ + + F T
Sbjct: 2499 RTPYNIL---SSPDYVGVTKGCSLENVYT--VSF-PKPGFVELSPVPIDVGTEINLSFST 2552
Query: 976 TSLDGLILYNSG------------DGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKP- 1022
+ G+IL SG G + V+ L +G L L GA ++ +P
Sbjct: 2553 KNESGIILLGSGGTPAPPRRKRRQTGQAYYVILLNRGRLE--VHLSTGARTMRKIVIRPE 2610
Query: 1023 ---LNDNQWHNVMISRDTSNLHTVKID-TKITTQITAGARNLDLKSDLYIGGVAKETYKS 1078
+D + H+V + R T + TV++D + Q + +++K L++GG E
Sbjct: 2611 PNLFHDGREHSVHVER-TRGIFTVQVDENRRYMQNLTVEQPIEVKK-LFVGGAPPEFQ-- 2666
Query: 1079 LPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVC 1138
P + F+GC+ ++ +N D F N I R C ED + +
Sbjct: 2667 -PSPLRNIPPFEGCIWNLVINSVPMDFARPVSFKNADIGR-CAHQKLREDEDGAAPAEIV 2724
Query: 1139 LQ----QWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTRADRLAI 1194
+Q F + + I SK G +R +AI
Sbjct: 2725 IQPEPVPTPAFPTPTPVLTHGPCAAESEPALLIGSKQFG------------LSRNSHIAI 2772
Query: 1195 GFSTVQKEAVL-----VRVDSSSGL---------GDYLELHIHQGKIGVKFNVGTDDIAI 1240
F + + L VR ++ SGL D+ + + G +++G+ D
Sbjct: 2773 AFDDTKVKNRLTIELEVRTEAESGLLFYMARINHADFATVQLRNGLPYFSYDLGSGDTHT 2832
Query: 1241 EESNAIINDGKYHVVRFTRSGGNATLQVD 1269
INDG++H ++ RS L VD
Sbjct: 2833 MIPTK-INDGQWHKIKIMRSKQEGILYVD 2860
Score = 79.3 bits (194), Expect = 3e-14
Identities = 99/447 (22%), Positives = 187/447 (41%), Gaps = 49/447 (10%)
Query: 282 INTAKPLTEKDNNVE-GLAHLM-MGDQGKSKGKEEYIATFKGSEYFCYDLSQNPIQSSS- 338
I+ KP+ E ++N++ ++ + + +Q + + ++ G + C + I+ S
Sbjct: 2110 IDKLKPIKELEDNLKKNISEIKELINQARKQANSIKVSVSSGGD--CIRTYKPEIKKGSY 2167
Query: 339 DEITLSFKTLQRNGLMLHTG--KSADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFN 396
+ I ++ KT + L+ + G K D++ + ++ G VS + ++GSG VE + +
Sbjct: 2168 NNIVVNVKTAVADNLLFYLGSAKFIDFLAIEMRKGKVSFLWDVGSGV--GRVEYPDLTID 2225
Query: 397 DNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTISVDGILTTTGYTQEDYTMLGSDDFFYV 456
D+ W+ + +R R + I ++ S+ S + GYT D + ++ +V
Sbjct: 2226 DSYWYRIVASRTGRNGT-ISVRALDGPKASIVPSTHHSTSPPGYTILD---VDANAMLFV 2281
Query: 457 GGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENV 516
GG + F GC+ E + N + L R K+GD K E
Sbjct: 2282 GGLTGKLKKADAVRVITFTGCMGETYFDNKPIGLWNFR-EKEGDCKGCTVSPQVEDSEGT 2340
Query: 517 ATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMI 576
D + + +S P ++ F FRT + L+++ +
Sbjct: 2341 IQFDGEGY----ALVSRPIRWYPNISTVMFKFRTFSSSALLMYLATRDLR---------- 2386
Query: 577 KVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRT 636
DF ++E+ DGH+ + D+GSG + + + NDG+W R + IS+ + T
Sbjct: 2387 --DFMSVELTDGHIKVSYDLGSGMASVVS-NQNHNDGKWKSFTLSRIQKQANISIVDIDT 2443
Query: 637 ------PYTAPGESEILDL--DDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLF 688
++ G + LDL DD++Y GGLP + + + Y GC++D+
Sbjct: 2444 NQEENIATSSSGNNFGLDLKADDKIYFGGLPTLR-------NLRPEVNLKKYSGCLKDIE 2496
Query: 689 IDGQSKDIRQMAEVQSTAGVKPSCSKE 715
I +I + GV CS E
Sbjct: 2497 ISRTPYNILSSPDY---VGVTKGCSLE 2520
Score = 68.2 bits (165), Expect = 6e-11
Identities = 160/819 (19%), Positives = 298/819 (36%), Gaps = 124/819 (15%)
Query: 327 YDLSQNPIQ--SSSDEITLSFKTLQRNGLMLH--TGKSADYVNLALKNGAVSLVINLGSG 382
Y L PI+ + + F+T + L+++ T D++++ L +G + + +LGSG
Sbjct: 2348 YALVSRPIRWYPNISTVMFKFRTFSSSALLMYLATRDLRDFMSVELTDGHIKVSYDLGSG 2407
Query: 383 AFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTISVDGILTTTGYTQ 442
+ N ND W ++R +Q N + + + + T+
Sbjct: 2408 MASVVS---NQNHNDGKWKSFTLSRIQKQ--------ANISIVDIDTNQEENIATSSSGN 2456
Query: 443 EDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPK 502
L +DD Y GG P+ +L + GCLK++ E+SR
Sbjct: 2457 NFGLDLKADDKIYFGGLPTLRNLRPEVNLKKYSGCLKDI---------EISRTPYNILSS 2507
Query: 503 MKIHGVV-AFKCENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSH 561
GV ENV T ++F P F+ L I+ F T +G+IL
Sbjct: 2508 PDYVGVTKGCSLENVYT---VSFPKP-GFVELSPVPIDVGTEINLSFSTKNESGIILLGS 2563
Query: 562 GKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVN---DGEWYHV 618
G K Q + ++ I + G L + L G+ T++ + + N DG + V
Sbjct: 2564 GGTPAPPRRKRRQTGQA-YYVILLNRGRLEVHLSTGARTMRKIVIRPEPNLFHDGREHSV 2622
Query: 619 DFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNY 678
+R T+ V+ R + +++ +L++GG P P + L N
Sbjct: 2623 HVERTRGIFTVQVDENRRYMQNLTVEQPIEVK-KLFVGGAP--------PEFQPSPLRNI 2673
Query: 679 G-YVGCIRDLFIDGQSKDIRQM-----AEVQSTAGVKPSCSKETAKPC------------ 720
+ GCI +L I+ D + A++ A K ++ A P
Sbjct: 2674 PPFEGCIWNLVINSVPMDFARPVSFKNADIGRCAHQKLREDEDGAAPAEIVIQPEPVPTP 2733
Query: 721 ---LSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHT 777
P +G C + G+ G S + D + ++ + + + T
Sbjct: 2734 AFPTPTPVLTHGPCAAESEPALL--IGSKQFGLSRNSHIAIAFDDTKVKNRLTIELEVRT 2791
Query: 778 EAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPET 837
EAE G+L + AD ++L G + +L G
Sbjct: 2792 EAES-----------GLLFYMARINHADFATVQLRNGLPYFSYDL---------GSGDTH 2831
Query: 838 LFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETGIITERRY 897
+ND +WH ++++R + L VD T + + + Y
Sbjct: 2832 TMIPTKINDGQWHKIKIMRSKQEGILYVDGASNRT---------ISPKKADILDVVGMLY 2882
Query: 898 LSSVPSNFIGH-LQSLTFNGMAYIDLCKNG--------DIDYCELNARFGFRNIIADPVT 948
+ +P N+ + +T++ ID C D++ + G A T
Sbjct: 2883 VGGLPINYTTRRIGPVTYS----IDGCVRNLHMAEAPADLEQPTSSFHVGTCFANAQRGT 2938
Query: 949 FKTKSSYV-ALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFD 1007
+ + + A+ + + + F+F+TT+ G++L S D + +E++ L + D
Sbjct: 2939 YFDGTGFAKAVGGFKVGLDLLVEFEFRTTTTTGVLLGISSQKMDGMGIEMIDEKLMFHVD 2998
Query: 1008 LGNGANLIKGSSNKP--LNDNQWHNVMISRDTSNLHTVKIDTKITTQI-TAGARNLDLKS 1064
G G + P L D QWH V ++ + ++ Q + + D
Sbjct: 2999 NGAGRFTAVYDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTSADTND 3058
Query: 1065 DLYIGGVAKETYK-----SLPKLVHAKEGFQGCLASVDL 1098
+++GG + + S+P F+GC+ S+ L
Sbjct: 3059 PVFVGGFPDDLKQFGLTTSIP--------FRGCIRSLKL 3089
Score = 63.5 bits (153), Expect = 1e-09
Identities = 87/382 (22%), Positives = 147/382 (38%), Gaps = 61/382 (15%)
Query: 341 ITLSFKTLQRNGLMLHTGK--SADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDN 398
I L +T +GL+ + + AD+ + L+NG +LGSG ++ K ND
Sbjct: 2785 IELEVRTEAESGLLFYMARINHADFATVQLRNGLPYFSYDLGSGDTHTMIPT---KINDG 2841
Query: 399 AWHDVKVTRNLRQHSGIGHAMVNKLHCSVTISVDGILTTTGYTQEDYTMLGSDDFFYVGG 458
WH +K+ R+ ++ GI + VDG T + + +L YVGG
Sbjct: 2842 QWHKIKIMRSKQE--GI-------------LYVDGASNRT-ISPKKADILDVVGMLYVGG 2885
Query: 459 SPSTADLPG-SPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVA 517
P PV+ + GC++ + LE P H F
Sbjct: 2886 LPINYTTRRIGPVTYSIDGCVRNLHMAEAPADLE--------QPTSSFHVGTCFANAQRG 2937
Query: 518 TLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIK 577
T F+ ++ + + F+FRTT G++L + K
Sbjct: 2938 TY----FDGTGFAKAVGGFKVGLDLLVEFEFRTTTTTGVLLGISSQ-------------K 2980
Query: 578 VDFFAIEMLDGHLYLLLDMGSG---TIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTL 634
+D IEM+D L +D G+G + + + DG+W+ V + ++V+
Sbjct: 2981 MDGMGIEMIDEKLMFHVDNGAGRFTAVYDAGVPGHLCDGQWHKVTANKIKHRIELTVDGN 3040
Query: 635 RTPYTAPG-ESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDL-FIDGQ 692
+ +P S D +D +++GG P++ T + + GCIR L G
Sbjct: 3041 QVEAQSPNPASTSADTNDPVFVGGFPDDLKQFGLTTSI-------PFRGCIRSLKLTKGT 3093
Query: 693 SKDIR-QMAEVQSTAGVKP-SC 712
K + A+ GV+P SC
Sbjct: 3094 GKPLEVNFAKALELRGVQPVSC 3115
Score = 49.3 bits (116), Expect = 3e-05
Identities = 30/106 (28%), Positives = 52/106 (49%), Gaps = 3/106 (2%)
Query: 54 MSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGA 113
+ +++T + GL+ Y DF + L R G S+ + + T++ T +NDG
Sbjct: 2785 IELEVRTEAESGLLFYMARINHADFATVQL-RNGLPYFSYDLGSGDTHTMIP-TKINDGQ 2842
Query: 114 WHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLP 159
WH ++I R + L++D + + K K + V L+VGGLP
Sbjct: 2843 WHKIKIMRSKQEGILYVDGASNRTISPK-KADILDVVGMLYVGGLP 2887
Score = 46.2 bits (108), Expect = 2e-04
Identities = 67/303 (22%), Positives = 119/303 (39%), Gaps = 47/303 (15%)
Query: 974 KTTSLDGLILY-NSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVM 1032
KT D L+ Y S DF+ +E+ KG + +++D+G+G ++ + ++D+ W+ ++
Sbjct: 2175 KTAVADNLLFYLGSAKFIDFLAIEMRKGKVSFLWDVGSGVGRVE-YPDLTIDDSYWYRIV 2233
Query: 1033 ISRDTSNLHTVKIDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGC 1092
SR N T R LD G A +P H+
Sbjct: 2234 ASRTGRN-------------GTISVRALD-------GPKA----SIVPSTHHSTSPPGYT 2269
Query: 1093 LASVDLN-----GRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSC 1147
+ VD N G L + A GC G E N+ + L +
Sbjct: 2270 ILDVDANAMLFVGGLTGKLKKADAVRVITFTGCMG------ETYFDNKPIGLWNFREKEG 2323
Query: 1148 DCSMTSFSGPLCNDPGTTYIFSKGGGQIT--YKWPPNDRPSTRADRLAIGFSTVQKEAVL 1205
DC + S + + GT +G ++ +W PN + F T A+L
Sbjct: 2324 DCKGCTVSPQVEDSEGTIQFDGEGYALVSRPIRWYPN------ISTVMFKFRTFSSSALL 2377
Query: 1206 VRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNAT 1265
+ + ++ L D++ + + G I V +++G+ +A SN NDGK+ +R A
Sbjct: 2378 MYL-ATRDLRDFMSVELTDGHIKVSYDLGS-GMASVVSNQNHNDGKWKSFTLSRIQKQAN 2435
Query: 1266 LQV 1268
+ +
Sbjct: 2436 ISI 2438
Score = 38.5 bits (88), Expect = 0.051
Identities = 34/149 (22%), Positives = 71/149 (47%), Gaps = 22/149 (14%)
Query: 52 SEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVND 111
S + F+ +T S+ L++Y DF+ + LT G +++S+ + A+++++ ND
Sbjct: 2362 STVMFKFRTFSSSALLMYLATRDLRDFMSVELT-DGHIKVSYDLGSGM-ASVVSNQNHND 2419
Query: 112 GAWHSV---RIRRQFRNTTLFIDQVEAKWVEVKSKRR----DMTVFSGLFVGGLPPELRA 164
G W S RI++Q + + ID + + + S D+ ++ GGLP
Sbjct: 2420 GKWKSFTLSRIQKQANISIVDIDTNQEENIATSSSGNNFGLDLKADDKIYFGGLP----- 2474
Query: 165 AALKLTLASVRER---EPFKGWIRDVRVN 190
TL ++R + + G ++D+ ++
Sbjct: 2475 -----TLRNLRPEVNLKKYSGCLKDIEIS 2498
Score = 35.8 bits (81), Expect = 0.33
Identities = 34/121 (28%), Positives = 58/121 (47%), Gaps = 15/121 (12%)
Query: 81 LILTRGGRLQLSFSIFCAEPATLLADTPVN---DGAWHSVRIRRQFRNTTLFIDQVEAKW 137
+IL GRL++ S ++ N DG HSV + R T+ +D+ ++
Sbjct: 2583 VILLNRGRLEVHLSTGARTMRKIVIRPEPNLFHDGREHSVHVERTRGIFTVQVDE-NRRY 2641
Query: 138 VEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQVLPV 197
++ + + + V LFVGG PPE + + L R PF+G I ++ +NS +P+
Sbjct: 2642 MQNLTVEQPIEV-KKLFVGGAPPEFQPSPL-------RNIPPFEGCIWNLVINS---VPM 2690
Query: 198 D 198
D
Sbjct: 2691 D 2691
Score = 35.0 bits (79), Expect = 0.56
Identities = 28/119 (23%), Positives = 47/119 (39%), Gaps = 12/119 (10%)
Query: 58 LKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSV 117
+KT A L+ Y F DFL + + R G++ + + D ++D W+ +
Sbjct: 2174 VKTAVADNLLFYLGSAKFIDFLAIEM-RKGKVSFLWDVGSGVGRVEYPDLTIDDSYWYRI 2232
Query: 118 RIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSG-----------LFVGGLPPELRAA 165
R RN T+ + ++ + T G LFVGGL +L+ A
Sbjct: 2233 VASRTGRNGTISVRALDGPKASIVPSTHHSTSPPGYTILDVDANAMLFVGGLTGKLKKA 2291
Score = 32.3 bits (72), Expect = 3.7
Identities = 17/79 (21%), Positives = 42/79 (53%), Gaps = 1/79 (1%)
Query: 1190 DRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIIND 1249
+ + + T + +L + S+ + D+L + + +GK+ ++VG+ +E + I+D
Sbjct: 2168 NNIVVNVKTAVADNLLFYLGSAKFI-DFLAIEMRKGKVSFLWDVGSGVGRVEYPDLTIDD 2226
Query: 1250 GKYHVVRFTRSGGNATLQV 1268
++ + +R+G N T+ V
Sbjct: 2227 SYWYRIVASRTGRNGTISV 2245
>gi|28559088 laminin alpha 2 subunit isoform a precursor [Homo
sapiens]
Length = 3122
Score = 104 bits (259), Expect = 8e-22
Identities = 165/753 (21%), Positives = 282/753 (37%), Gaps = 141/753 (18%)
Query: 578 VDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTP 637
+DF AIEM G + L D+GSG +++ ++D WY + R GR+GTISV L P
Sbjct: 2192 IDFLAIEMRKGKVSFLWDVGSGVGRVEYPDLTIDDSYWYRIVASRTGRNGTISVRALDGP 2251
Query: 638 Y----------TAPGESEILDLDDE--LYLGGLPENKAGLVFPTEVWTALLNYGYVGCIR 685
T+P ILD+D L++GGL K V T + GC+
Sbjct: 2252 KASIVPSTHHSTSPPGYTILDVDANAMLFVGGLT-GKLKKADAVRVIT------FTGCMG 2304
Query: 686 DLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGT 745
+ + D + + E + K C +P V D GT
Sbjct: 2305 ETYFDNKPIGLWNFREKEGDC-----------KGCTVSP-------------QVEDSEGT 2340
Query: 746 GYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSAD 805
+ +DG + + P+ + V +FR+ + +LM +RD D
Sbjct: 2341 -------------IQFDGEGYALVSRPIRWYPNISTVMFKFRTFSSSALLMYLATRDLRD 2387
Query: 806 TLRLELDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTV 865
+ +EL G +K++ +L G ++ + N ND +W + + R K +++
Sbjct: 2388 FMSVELTDGHIKVSYDL---------GSGMASVVSNQNHNDGKWKSFTLSRIQKQANISI 2438
Query: 866 DD-----QQAMTGQMAGDHTRLEF---HNIETGIITERRYLSSVP------SNFIGHLQS 911
D ++ + +G++ L+ I G + R LS + G L+
Sbjct: 2439 VDIDTNQEENIATSSSGNNFGLDLKADDKIYFGGLPTLRNLSMKARPEVNLKKYSGCLKD 2498
Query: 912 LTFNGMAYIDLCKNGDIDYCELNARFGFRNIIADPVTFKTKSSYVALATLQAYTSMHLFF 971
+ + Y L DY + N+ V+F K +V L+ + +
Sbjct: 2499 IEISRTPYNIL---SSPDYVGVTKGCSLENVYT--VSF-PKPGFVELSPVPIDVGTEINL 2552
Query: 972 QFKTTSLDGLILYNSG------------DGNDFIVVELVKGYLHYVFDLGNGANLIKGSS 1019
F T + G+IL SG G + V+ L +G L L GA ++
Sbjct: 2553 SFSTKNESGIILLGSGGTPAPPRRKRRQTGQAYYVILLNRGRLE--VHLSTGARTMRKIV 2610
Query: 1020 NKP----LNDNQWHNVMISRDTSNLHTVKID-TKITTQITAGARNLDLKSDLYIGGVAKE 1074
+P +D + H+V + R T + TV++D + Q + +++K L++GG E
Sbjct: 2611 IRPEPNLFHDGREHSVHVER-TRGIFTVQVDENRRYMQNLTVEQPIEVKK-LFVGGAPPE 2668
Query: 1075 TYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSN 1134
P + F+GC+ ++ +N D F N I R C ED +
Sbjct: 2669 FQ---PSPLRNIPPFEGCIWNLVINSVPMDFARPVSFKNADIGR-CAHQKLREDEDGAAP 2724
Query: 1135 QGVCLQ----QWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTRAD 1190
+ +Q F + + I SK G +R
Sbjct: 2725 AEIVIQPEPVPTPAFPTPTPVLTHGPCAAESEPALLIGSKQFG------------LSRNS 2772
Query: 1191 RLAIGFSTVQKEAVL-----VRVDSSSGL---------GDYLELHIHQGKIGVKFNVGTD 1236
+AI F + + L VR ++ SGL D+ + + G +++G+
Sbjct: 2773 HIAIAFDDTKVKNRLTIELEVRTEAESGLLFYMARINHADFATVQLRNGLPYFSYDLGSG 2832
Query: 1237 DIAIEESNAIINDGKYHVVRFTRSGGNATLQVD 1269
D INDG++H ++ RS L VD
Sbjct: 2833 DTHTMIPTK-INDGQWHKIKIMRSKQEGILYVD 2864
Score = 80.9 bits (198), Expect = 9e-15
Identities = 101/447 (22%), Positives = 187/447 (41%), Gaps = 45/447 (10%)
Query: 282 INTAKPLTEKDNNVE-GLAHLM-MGDQGKSKGKEEYIATFKGSEYFCYDLSQNPIQSSS- 338
I+ KP+ E ++N++ ++ + + +Q + + ++ G + C + I+ S
Sbjct: 2110 IDKLKPIKELEDNLKKNISEIKELINQARKQANSIKVSVSSGGD--CIRTYKPEIKKGSY 2167
Query: 339 DEITLSFKTLQRNGLMLHTG--KSADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFN 396
+ I ++ KT + L+ + G K D++ + ++ G VS + ++GSG VE + +
Sbjct: 2168 NNIVVNVKTAVADNLLFYLGSAKFIDFLAIEMRKGKVSFLWDVGSGV--GRVEYPDLTID 2225
Query: 397 DNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTISVDGILTTTGYTQEDYTMLGSDDFFYV 456
D+ W+ + +R R + I ++ S+ S + GYT D + ++ +V
Sbjct: 2226 DSYWYRIVASRTGRNGT-ISVRALDGPKASIVPSTHHSTSPPGYTILD---VDANAMLFV 2281
Query: 457 GGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENV 516
GG + F GC+ E + N + L R K+GD K E
Sbjct: 2282 GGLTGKLKKADAVRVITFTGCMGETYFDNKPIGLWNFR-EKEGDCKGCTVSPQVEDSEGT 2340
Query: 517 ATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMI 576
D + + +S P ++ F FRT + L+++ +
Sbjct: 2341 IQFDGEGY----ALVSRPIRWYPNISTVMFKFRTFSSSALLMYLATRDLR---------- 2386
Query: 577 KVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRT 636
DF ++E+ DGH+ + D+GSG + + + NDG+W R + IS+ + T
Sbjct: 2387 --DFMSVELTDGHIKVSYDLGSGMASVVS-NQNHNDGKWKSFTLSRIQKQANISIVDIDT 2443
Query: 637 ------PYTAPGESEILDL--DDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLF 688
++ G + LDL DD++Y GGLP + L L Y GC++D+
Sbjct: 2444 NQEENIATSSSGNNFGLDLKADDKIYFGGLPTLR-NLSMKARPEVNLKKYS--GCLKDIE 2500
Query: 689 IDGQSKDIRQMAEVQSTAGVKPSCSKE 715
I +I + GV CS E
Sbjct: 2501 ISRTPYNILSSPDY---VGVTKGCSLE 2524
Score = 65.1 bits (157), Expect = 5e-10
Identities = 162/823 (19%), Positives = 300/823 (36%), Gaps = 128/823 (15%)
Query: 327 YDLSQNPIQ--SSSDEITLSFKTLQRNGLMLH--TGKSADYVNLALKNGAVSLVINLGSG 382
Y L PI+ + + F+T + L+++ T D++++ L +G + + +LGSG
Sbjct: 2348 YALVSRPIRWYPNISTVMFKFRTFSSSALLMYLATRDLRDFMSVELTDGHIKVSYDLGSG 2407
Query: 383 AFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTISVDGILTTTGYTQ 442
+ N ND W ++R +Q N + + + + T+
Sbjct: 2408 MASVVS---NQNHNDGKWKSFTLSRIQKQ--------ANISIVDIDTNQEENIATSSSGN 2456
Query: 443 EDYTMLGSDDFFYVGGSPSTADLP--GSPVSN--NFMGCLKEVVYKNNDVRLELSRLAKQ 498
L +DD Y GG P+ +L P N + GCLK++ E+SR
Sbjct: 2457 NFGLDLKADDKIYFGGLPTLRNLSMKARPEVNLKKYSGCLKDI---------EISRTPYN 2507
Query: 499 GDPKMKIHGVV-AFKCENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLI 557
GV ENV T ++F P F+ L I+ F T +G+I
Sbjct: 2508 ILSSPDYVGVTKGCSLENVYT---VSFPKP-GFVELSPVPIDVGTEINLSFSTKNESGII 2563
Query: 558 LFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVN---DGE 614
L G K Q + ++ I + G L + L G+ T++ + + N DG
Sbjct: 2564 LLGSGGTPAPPRRKRRQTGQA-YYVILLNRGRLEVHLSTGARTMRKIVIRPEPNLFHDGR 2622
Query: 615 WYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTA 674
+ V +R T+ V+ R + +++ +L++GG P P +
Sbjct: 2623 EHSVHVERTRGIFTVQVDENRRYMQNLTVEQPIEVK-KLFVGGAP--------PEFQPSP 2673
Query: 675 LLNYG-YVGCIRDLFIDGQSKDIRQM-----AEVQSTAGVKPSCSKETAKPC-------- 720
L N + GCI +L I+ D + A++ A K ++ A P
Sbjct: 2674 LRNIPPFEGCIWNLVINSVPMDFARPVSFKNADIGRCAHQKLREDEDGAAPAEIVIQPEP 2733
Query: 721 -------LSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPV 773
P +G C + G+ G S + D + ++ + +
Sbjct: 2734 VPTPAFPTPTPVLTHGPCAAESEPALL--IGSKQFGLSRNSHIAIAFDDTKVKNRLTIEL 2791
Query: 774 VMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSK 833
+ TEAE G+L + AD ++L G + +L
Sbjct: 2792 EVRTEAES-----------GLLFYMARINHADFATVQLRNGLPYFSYDL---------GS 2831
Query: 834 GPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETGIIT 893
G +ND +WH ++++R + L VD T + + +
Sbjct: 2832 GDTHTMIPTKINDGQWHKIKIMRSKQEGILYVDGASNRT---------ISPKKADILDVV 2882
Query: 894 ERRYLSSVPSNFIGH-LQSLTFNGMAYIDLCKNG--------DIDYCELNARFGFRNIIA 944
Y+ +P N+ + +T++ ID C D++ + G A
Sbjct: 2883 GMLYVGGLPINYTTRRIGPVTYS----IDGCVRNLHMAEAPADLEQPTSSFHVGTCFANA 2938
Query: 945 DPVTFKTKSSYV-ALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLH 1003
T+ + + A+ + + + F+F+TT+ G++L S D + +E++ L
Sbjct: 2939 QRGTYFDGTGFAKAVGGFKVGLDLLVEFEFRTTTTTGVLLGISSQKMDGMGIEMIDEKLM 2998
Query: 1004 YVFDLGNGANLIKGSSNKP--LNDNQWHNVMISRDTSNLHTVKIDTKITTQI-TAGARNL 1060
+ D G G + P L D QWH V ++ + ++ Q + +
Sbjct: 2999 FHVDNGAGRFTAVYDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTSA 3058
Query: 1061 DLKSDLYIGGVAKETYK-----SLPKLVHAKEGFQGCLASVDL 1098
D +++GG + + S+P F+GC+ S+ L
Sbjct: 3059 DTNDPVFVGGFPDDLKQFGLTTSIP--------FRGCIRSLKL 3093
Score = 63.5 bits (153), Expect = 1e-09
Identities = 87/382 (22%), Positives = 147/382 (38%), Gaps = 61/382 (15%)
Query: 341 ITLSFKTLQRNGLMLHTGK--SADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDN 398
I L +T +GL+ + + AD+ + L+NG +LGSG ++ K ND
Sbjct: 2789 IELEVRTEAESGLLFYMARINHADFATVQLRNGLPYFSYDLGSGDTHTMIPT---KINDG 2845
Query: 399 AWHDVKVTRNLRQHSGIGHAMVNKLHCSVTISVDGILTTTGYTQEDYTMLGSDDFFYVGG 458
WH +K+ R+ ++ GI + VDG T + + +L YVGG
Sbjct: 2846 QWHKIKIMRSKQE--GI-------------LYVDGASNRT-ISPKKADILDVVGMLYVGG 2889
Query: 459 SPSTADLPG-SPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVA 517
P PV+ + GC++ + LE P H F
Sbjct: 2890 LPINYTTRRIGPVTYSIDGCVRNLHMAEAPADLE--------QPTSSFHVGTCFANAQRG 2941
Query: 518 TLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIK 577
T F+ ++ + + F+FRTT G++L + K
Sbjct: 2942 TY----FDGTGFAKAVGGFKVGLDLLVEFEFRTTTTTGVLLGISSQ-------------K 2984
Query: 578 VDFFAIEMLDGHLYLLLDMGSG---TIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTL 634
+D IEM+D L +D G+G + + + DG+W+ V + ++V+
Sbjct: 2985 MDGMGIEMIDEKLMFHVDNGAGRFTAVYDAGVPGHLCDGQWHKVTANKIKHRIELTVDGN 3044
Query: 635 RTPYTAPG-ESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDL-FIDGQ 692
+ +P S D +D +++GG P++ T + + GCIR L G
Sbjct: 3045 QVEAQSPNPASTSADTNDPVFVGGFPDDLKQFGLTTSI-------PFRGCIRSLKLTKGT 3097
Query: 693 SKDIR-QMAEVQSTAGVKP-SC 712
K + A+ GV+P SC
Sbjct: 3098 GKPLEVNFAKALELRGVQPVSC 3119
Score = 49.3 bits (116), Expect = 3e-05
Identities = 30/106 (28%), Positives = 52/106 (49%), Gaps = 3/106 (2%)
Query: 54 MSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGA 113
+ +++T + GL+ Y DF + L R G S+ + + T++ T +NDG
Sbjct: 2789 IELEVRTEAESGLLFYMARINHADFATVQL-RNGLPYFSYDLGSGDTHTMIP-TKINDGQ 2846
Query: 114 WHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLP 159
WH ++I R + L++D + + K K + V L+VGGLP
Sbjct: 2847 WHKIKIMRSKQEGILYVDGASNRTISPK-KADILDVVGMLYVGGLP 2891
Score = 46.2 bits (108), Expect = 2e-04
Identities = 67/303 (22%), Positives = 119/303 (39%), Gaps = 47/303 (15%)
Query: 974 KTTSLDGLILY-NSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVM 1032
KT D L+ Y S DF+ +E+ KG + +++D+G+G ++ + ++D+ W+ ++
Sbjct: 2175 KTAVADNLLFYLGSAKFIDFLAIEMRKGKVSFLWDVGSGVGRVE-YPDLTIDDSYWYRIV 2233
Query: 1033 ISRDTSNLHTVKIDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGC 1092
SR N T R LD G A +P H+
Sbjct: 2234 ASRTGRN-------------GTISVRALD-------GPKA----SIVPSTHHSTSPPGYT 2269
Query: 1093 LASVDLN-----GRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSC 1147
+ VD N G L + A GC G E N+ + L +
Sbjct: 2270 ILDVDANAMLFVGGLTGKLKKADAVRVITFTGCMG------ETYFDNKPIGLWNFREKEG 2323
Query: 1148 DCSMTSFSGPLCNDPGTTYIFSKGGGQIT--YKWPPNDRPSTRADRLAIGFSTVQKEAVL 1205
DC + S + + GT +G ++ +W PN + F T A+L
Sbjct: 2324 DCKGCTVSPQVEDSEGTIQFDGEGYALVSRPIRWYPN------ISTVMFKFRTFSSSALL 2377
Query: 1206 VRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNAT 1265
+ + ++ L D++ + + G I V +++G+ +A SN NDGK+ +R A
Sbjct: 2378 MYL-ATRDLRDFMSVELTDGHIKVSYDLGS-GMASVVSNQNHNDGKWKSFTLSRIQKQAN 2435
Query: 1266 LQV 1268
+ +
Sbjct: 2436 ISI 2438
Score = 38.1 bits (87), Expect = 0.067
Identities = 34/146 (23%), Positives = 71/146 (48%), Gaps = 12/146 (8%)
Query: 52 SEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVND 111
S + F+ +T S+ L++Y DF+ + LT G +++S+ + A+++++ ND
Sbjct: 2362 STVMFKFRTFSSSALLMYLATRDLRDFMSVELT-DGHIKVSYDLGSGM-ASVVSNQNHND 2419
Query: 112 GAWHSV---RIRRQFRNTTLFIDQVEAKWVEVKSKRR----DMTVFSGLFVGGLPPELRA 164
G W S RI++Q + + ID + + + S D+ ++ GGL P LR
Sbjct: 2420 GKWKSFTLSRIQKQANISIVDIDTNQEENIATSSSGNNFGLDLKADDKIYFGGL-PTLRN 2478
Query: 165 AALKLTLASVREREPFKGWIRDVRVN 190
++K + + G ++D+ ++
Sbjct: 2479 LSMK--ARPEVNLKKYSGCLKDIEIS 2502
Score = 35.8 bits (81), Expect = 0.33
Identities = 34/121 (28%), Positives = 58/121 (47%), Gaps = 15/121 (12%)
Query: 81 LILTRGGRLQLSFSIFCAEPATLLADTPVN---DGAWHSVRIRRQFRNTTLFIDQVEAKW 137
+IL GRL++ S ++ N DG HSV + R T+ +D+ ++
Sbjct: 2587 VILLNRGRLEVHLSTGARTMRKIVIRPEPNLFHDGREHSVHVERTRGIFTVQVDE-NRRY 2645
Query: 138 VEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQVLPV 197
++ + + + V LFVGG PPE + + L R PF+G I ++ +NS +P+
Sbjct: 2646 MQNLTVEQPIEV-KKLFVGGAPPEFQPSPL-------RNIPPFEGCIWNLVINS---VPM 2694
Query: 198 D 198
D
Sbjct: 2695 D 2695
Score = 35.0 bits (79), Expect = 0.56
Identities = 28/119 (23%), Positives = 47/119 (39%), Gaps = 12/119 (10%)
Query: 58 LKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSV 117
+KT A L+ Y F DFL + + R G++ + + D ++D W+ +
Sbjct: 2174 VKTAVADNLLFYLGSAKFIDFLAIEM-RKGKVSFLWDVGSGVGRVEYPDLTIDDSYWYRI 2232
Query: 118 RIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSG-----------LFVGGLPPELRAA 165
R RN T+ + ++ + T G LFVGGL +L+ A
Sbjct: 2233 VASRTGRNGTISVRALDGPKASIVPSTHHSTSPPGYTILDVDANAMLFVGGLTGKLKKA 2291
Score = 32.3 bits (72), Expect = 3.7
Identities = 17/79 (21%), Positives = 42/79 (53%), Gaps = 1/79 (1%)
Query: 1190 DRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIIND 1249
+ + + T + +L + S+ + D+L + + +GK+ ++VG+ +E + I+D
Sbjct: 2168 NNIVVNVKTAVADNLLFYLGSAKFI-DFLAIEMRKGKVSFLWDVGSGVGRVEYPDLTIDD 2226
Query: 1250 GKYHVVRFTRSGGNATLQV 1268
++ + +R+G N T+ V
Sbjct: 2227 SYWYRIVASRTGRNGTISV 2245
>gi|33469935 EGF-like, fibronectin type III and laminin G domains
isoform 3 [Homo sapiens]
Length = 375
Score = 97.8 bits (242), Expect = 7e-20
Identities = 83/314 (26%), Positives = 141/314 (44%), Gaps = 21/314 (6%)
Query: 967 MHLFFQFKTTSLDGLILYNSGDGN-DFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLND 1025
M F+ S DG++LY+ G+ DF+ + L G++ + FD G+G +++ S PL
Sbjct: 1 MEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLR--SEDPLTL 58
Query: 1026 NQWHNVMISRDTSNLHTVKIDTK--ITTQITAGARNLDLKSDLYIGGVAKETYKSLPKLV 1083
WH + +SR N +++D + + G + +D++IGGV Y + K
Sbjct: 59 GNWHELRVSRTAKN-GILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPN--YDDVKKNS 115
Query: 1084 HAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWD 1143
+ F G + + LN R + D F +G E + C C++ G C + +
Sbjct: 116 GVLKPFSGSIQKIILNDRTIHVKHD--FTSGV---NVENAAHPCVRAPCAHGGSCRPRKE 170
Query: 1144 GFSCDCSMTSFSGPLCNDPGTTYIFSK---GGGQITYKWPP-NDRPSTRADRLAIGFSTV 1199
G+ CDC + F G C I G +TY P R S + + F T
Sbjct: 171 GYDCDCPL-GFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTT 229
Query: 1200 QKEAVLV-RVDS-SSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRF 1257
K+ +L+ R DS D++ L + G + +N+G+ +A N NDG++H V+
Sbjct: 230 AKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGS-GVASIMVNGSFNDGRWHRVKA 288
Query: 1258 TRSGGNATLQVDSW 1271
R G + + VD +
Sbjct: 289 VRDGQSGKITVDDY 302
Score = 96.3 bits (238), Expect = 2e-19
Identities = 89/401 (22%), Positives = 173/401 (43%), Gaps = 68/401 (16%)
Query: 548 FRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALL 607
FR +G++L+S+ DF +I + GH+ D GSGT +++
Sbjct: 7 FRPDSGDGVLLYSYDTGSK------------DFLSINLAGGHVEFRFDCGSGTGVLRSE- 53
Query: 608 KKVNDGEWYHVDFQRDGRSGTISVNTLR-TPYTAPGESEILDLDDELYLGGLP-----EN 661
+ G W+ + R ++G + V+ + A G + + ++++GG+P +
Sbjct: 54 DPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKK 113
Query: 662 KAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPCL 721
+G++ P + G I+ + ++ ++ ++ T+GV + A PC+
Sbjct: 114 NSGVLKP-----------FSGSIQKIILNDRTIHVKH----DFTSGVNV---ENAAHPCV 155
Query: 722 SNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREAT----VLSYDGSMFMKIQLPVVMHT 777
PC + G CR Y CDC G+ G C++ + + G ++ P ++
Sbjct: 156 RAPCAHGGSCRPRKEGYDCDCP-LGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKR 214
Query: 778 EA---EDVSLRFRSQRAYGILM---ATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNS 831
+ +V +RF++ G+L+ + R ++D + L L G + + NL
Sbjct: 215 VSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNL--------- 265
Query: 832 SKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNI---- 887
G ++ + ND WH V+ VR G+S K+TVDD A TG+ G +L +
Sbjct: 266 GSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVG 325
Query: 888 ---ETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKN 925
E + T R+Y+ + +G + T + +I L ++
Sbjct: 326 GMKEIALHTNRQYMRGL----VGCISHFTLSTDYHISLVED 362
Score = 90.5 bits (223), Expect = 1e-17
Identities = 107/442 (24%), Positives = 164/442 (37%), Gaps = 113/442 (25%)
Query: 54 MSFQLKTR--SARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLL-ADTPVN 110
M F++ R S G++LY D G DFL + L GG ++ F C +L ++ P+
Sbjct: 1 MEFEITFRPDSGDGVLLYSYDTGSKDFLSINLA-GGHVEFRFD--CGSGTGVLRSEDPLT 57
Query: 111 DGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPP----ELRAAA 166
G WH +R+ R +N L +D+ + + + + +F+GG+P + +
Sbjct: 58 LGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGV 117
Query: 167 LKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGG 226
LK PF G I+ + +N + VK D + G + A
Sbjct: 118 LK----------PFSGSIQKIILNDRTI------HVKHDF----TSGVNVENAAHPCVRA 157
Query: 227 VCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEIKFGLQCVLPVLLHDNDQGKYCCINTAK 286
C +GG C + CDC GF G C + I ++
Sbjct: 158 PCAHGGSCRPRKEGYDCDCP-LGFEGLHCQKAIIEAIE---------------------- 194
Query: 287 PLTEKDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNP-----IQSSSDEI 341
I F G Y YD NP + S +
Sbjct: 195 -----------------------------IPQFIGRSYLTYD---NPDILKRVSGSRSNV 222
Query: 342 TLSFKTLQRNGLMLHTGKS-----ADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFN 396
+ FKT ++GL+L G S +D+++L L++GA+ NLGSG +V NG FN
Sbjct: 223 FMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMV---NGSFN 279
Query: 397 DNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTISVDGILTTTGYTQEDYTMLGSDDFFYV 456
D WH VK R+ + S I+VD TG + L + YV
Sbjct: 280 DGRWHRVKAVRDGQ---------------SGKITVDDYGARTGKSPGMMRQLNINGALYV 324
Query: 457 GGSPSTADLPGSPVSNNFMGCL 478
GG A +GC+
Sbjct: 325 GGMKEIALHTNRQYMRGLVGCI 346
Score = 43.5 bits (101), Expect = 0.002
Identities = 30/110 (27%), Positives = 54/110 (49%), Gaps = 5/110 (4%)
Query: 52 SEMSFQLKTRSARGLVLYFDDEGF---CDFLELILTRGGRLQLSFSIFCAEPATLLADTP 108
S + + KT + GL+L+ D DF+ L L R G L S+++ A+++ +
Sbjct: 220 SNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGL-RDGALVFSYNLGSGV-ASIMVNGS 277
Query: 109 VNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGL 158
NDG WH V+ R ++ + +D A+ + R + + L+VGG+
Sbjct: 278 FNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGM 327
Score = 34.3 bits (77), Expect = 0.96
Identities = 18/69 (26%), Positives = 35/69 (50%), Gaps = 1/69 (1%)
Query: 1212 SGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSW 1271
+G D+L +++ G + +F+ G+ + S + G +H +R +R+ N LQVD
Sbjct: 22 TGSKDFLSINLAGGHVEFRFDCGSGT-GVLRSEDPLTLGNWHELRVSRTAKNGILQVDKQ 80
Query: 1272 PVIERYPAG 1280
++E G
Sbjct: 81 KIVEGMAEG 89
>gi|41327708 crumbs homolog 1 precursor [Homo sapiens]
Length = 1406
Score = 95.1 bits (235), Expect = 5e-19
Identities = 143/644 (22%), Positives = 249/644 (38%), Gaps = 129/644 (20%)
Query: 720 CLSNPCKNNGMC----RDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQL-PVV 774
C C NNG C +DG + + C C +GY G CE AT LS++G F+ ++ V
Sbjct: 445 CTHQQCLNNGTCIPHFQDGQHGFSCLCP-SGYTGSLCEI-ATTLSFEGDGFLWVKSGSVT 502
Query: 775 MHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKG 834
+++LRF++ + +L+ ++RD ++LEL +G + L++ ++ N SK
Sbjct: 503 TKGSVCNIALRFQTVQPMALLLFRSNRDVF--VKLELLSGYIHLSIQVN------NQSK- 553
Query: 835 PETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLE-------FHN- 886
LF +N +D EWH V V+ +++ LT+ D +A T LE F N
Sbjct: 554 -VLLFISHNTSDGEWHFVEVIF-AEAVTLTLIDDSCKEKCIAKAPTPLESDQSICAFQNS 611
Query: 887 ---------IETGIITERRYLSSVPSNFIGHLQSLT--FNGMAYIDLCKNGDI------- 928
G+ Y +F+G LQ + +N + ++ +
Sbjct: 612 FLGGLPVGMTSNGVALLNFYNMPSTPSFVGCLQDIKIDWNHITLENISSGSSLNVKAGCV 671
Query: 929 --DYCE----------LNARFGF--------------RNIIADPVTFKTKSSYVALATLQ 962
D+CE +N + R +A + YV +
Sbjct: 672 RKDWCESQPCQSRGRCINLWLSYQCDCHRPYEGPNCLREYVAGRFGQDDSTGYVIFTLDE 731
Query: 963 AY-TSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNK 1021
+Y ++ L +T GL+L +I V L +G L + N L+
Sbjct: 732 SYGDTISLSMFVRTLQPSGLLLALENSTYQYIRVWLERGRLAMLTP--NSPKLVV---KF 786
Query: 1022 PLNDNQWHNVMISRDTSNLHTVKIDTKITTQ----ITAGARNLDLKSDLYIGGVAKETYK 1077
LND H + + + KI+ ++Q I+A ++ +YIGG+ +
Sbjct: 787 VLNDGNVHLISLK-----IKPYKIELYQSSQNLGFISASTWKIEKGDVIYIGGLPDKQET 841
Query: 1078 SLPKLVHAKEGFQGCLASVDLNGR----LPDLISDALF--CNGQIERGCEGPSTTCQEDS 1131
L F+GC+ V LN + P+ ++A + +GC G ++ C+ +
Sbjct: 842 ELNGGF-----FKGCIQDVRLNNQNLEFFPNPTNNASLNPVLVNVTQGCAGDNS-CKSNP 895
Query: 1132 CSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPG-----------------------TTYIF 1168
C N GVC +WD FSC C + SG C + +F
Sbjct: 896 CHNGGVCHSRWDDFSCSCPALT-SGKACEEVQWCGFSPCPHGAQCQPVLQGFECIANAVF 954
Query: 1169 SKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIG 1228
+ GQI ++ N + + GF T +++ + ++L + I ++
Sbjct: 955 NGQSGQILFR--SNGNITRELTNITFGFRTRDANVIILHAEKEP---EFLNISIQDSRLF 1009
Query: 1229 VKFNVGTDDIAIE-ESNAIINDGKYHVVRFTRSGGNATLQVDSW 1271
+ G + S +NDG +H V T S + Q W
Sbjct: 1010 FQLQSGNSFYMLSLTSLQSVNDGTWHEV--TLSMTDPLSQTSRW 1051
Score = 74.7 bits (182), Expect = 6e-13
Identities = 100/421 (23%), Positives = 177/421 (42%), Gaps = 62/421 (14%)
Query: 467 GSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFET 526
G S+ +GC + NN + + + G + G CE TL +FE
Sbjct: 435 GRDCSDILLGCTHQQCL-NNGTCIPHFQDGQHGFSCLCPSGYTGSLCEIATTL---SFEG 490
Query: 527 PESFISLPKWNAKKTGS---ISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAI 583
+ F+ + + GS I+ F+T +P L+LF R +D F +
Sbjct: 491 -DGFLWVKSGSVTTKGSVCNIALRFQTVQPMALLLF-----RSNRDV---------FVKL 535
Query: 584 EMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVD-FQRDGRSGTISVNTLRTPYTAPG 642
E+L G+++L + + + + + + +DGEW+ V+ + + T+ ++ + A
Sbjct: 536 ELLSGYIHLSIQVNNQSKVLLFISHNTSDGEWHFVEVIFAEAVTLTLIDDSCKEKCIAKA 595
Query: 643 ESEILDLDDEL------YLGGLPENKAGLVFPTEVWTALLNY-------GYVGCIRDLFI 689
+ L+ D + +LGGLP V T ALLN+ +VGC++D+ I
Sbjct: 596 PTP-LESDQSICAFQNSFLGGLP------VGMTSNGVALLNFYNMPSTPSFVGCLQDIKI 648
Query: 690 DGQSKDIRQMAEVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLG 749
D + ++ S+ VK C ++ C S PC++ G C + W Y CDC Y G
Sbjct: 649 DWNHITLENISS-GSSLNVKAGCVRKDW--CESQPCQSRGRCINLWLSYQCDCH-RPYEG 704
Query: 750 RSCERE--ATVLSYDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTL 807
+C RE A D S I + + +S+ R+ + G+L+A + +
Sbjct: 705 PNCLREYVAGRFGQDDSTGYVIFTLDESYGDTISLSMFVRTLQPSGLLLA-LENSTYQYI 763
Query: 808 RLELDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDD 867
R+ L+ GR+ + + NS K L + LND H + + + ++L
Sbjct: 764 RVWLERGRLAM--------LTPNSPK----LVVKFVLNDGNVHLISLKIKPYKIELYQSS 811
Query: 868 Q 868
Q
Sbjct: 812 Q 812
Score = 68.2 bits (165), Expect = 6e-11
Identities = 112/565 (19%), Positives = 210/565 (37%), Gaps = 91/565 (16%)
Query: 715 ETAKP-CLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPV 773
ET P C S PC NN C D + Y C C GY G CE + + + P
Sbjct: 299 ETLMPLCWSKPCHNNATCEDSVDNYTCHC-WPGYTGAQCEIDLNECNSN---------PC 348
Query: 774 VMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLD---CIRINCN 830
+ E ++S + R G+ + + +++ + + G + D C C
Sbjct: 349 QSNGECVELSSEKQYGRITGLPSSFSYHEASGYVCI-CQPGFTGIHCEEDVNECSSNPCQ 407
Query: 831 SSKGPETLFAGYNLN---DNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNI 887
+ E L Y + DN T R + L QQ + H + H
Sbjct: 408 NGGTCENLPGNYTCHCPFDNLSRTFYGGRDCSDILLGCTHQQCLNNGTCIPHFQDGQHG- 466
Query: 888 ETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIADPV 947
+ PS + G L + L GD GF + + V
Sbjct: 467 ---------FSCLCPSGYTGSLCEIATT------LSFEGD----------GFLWVKSGSV 501
Query: 948 TFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFD 1007
T K +AL +F+T L+L+ S + + F+ +EL+ GY+H
Sbjct: 502 TTKGSVCNIAL-------------RFQTVQPMALLLFRS-NRDVFVKLELLSGYIHLSIQ 547
Query: 1008 LGNGANLIKGSSNKPLNDNQWHNV-----------MISRDTSNLHTVKIDTKITTQITAG 1056
+ N + ++ S+ +D +WH V +I K T + + +
Sbjct: 548 VNNQSKVLLFISHNT-SDGEWHFVEVIFAEAVTLTLIDDSCKEKCIAKAPTPLESDQSIC 606
Query: 1057 ARNLDLKSDLYIG----GVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFC 1112
A L +G GVA + ++P + F GCL + ++ L + +
Sbjct: 607 AFQNSFLGGLPVGMTSNGVALLNFYNMP----STPSFVGCLQDIKIDWNHITLENISSGS 662
Query: 1113 NGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGG 1172
+ ++ GC C+ C ++G C+ W + CDC + GP C Y+ + G
Sbjct: 663 SLNVKAGCVRKDW-CESQPCQSRGRCINLWLSYQCDCH-RPYEGPNCL---REYVAGRFG 717
Query: 1173 GQITYKWPPNDRPSTRADRLAIGF--STVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVK 1230
+ + + D +++ T+Q +L+ +++S+ Y+ + + +G++ +
Sbjct: 718 QDDSTGYVIFTLDESYGDTISLSMFVRTLQPSGLLLALENST--YQYIRVWLERGRLAM- 774
Query: 1231 FNVGTDDIAIEESNAIINDGKYHVV 1255
+ + ++ ++NDG H++
Sbjct: 775 LTPNSPKLVVK---FVLNDGNVHLI 796
Score = 67.8 bits (164), Expect = 8e-11
Identities = 128/602 (21%), Positives = 212/602 (35%), Gaps = 131/602 (21%)
Query: 214 GSPCEAG-EEGEGGVCLNGGVCSVVDDQAVCDC-----SRTGFRGKDCSQEIKFGLQCVL 267
G CE E C NGG C + C C SRT + G+DCS
Sbjct: 391 GIHCEEDVNECSSNPCQNGGTCENLPGNYTCHCPFDNLSRTFYGGRDCSD---------- 440
Query: 268 PVLLHDNDQGKYCCINTAKPLTEKDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCY 327
+LL Q C+N + + G + L S + +F+G +
Sbjct: 441 -ILLGCTHQQ---CLNNGTCIPHFQDGQHGFSCLCPSGYTGSLCEIATTLSFEGDGFLWV 496
Query: 328 DLSQNPIQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVINLGSGAFEAL 387
+ S I L F+T+Q L+L +V L L +G + L I + + + L
Sbjct: 497 KSGSVTTKGSVCNIALRFQTVQPMALLLFRSNRDVFVKLELLSGYIHLSIQVNNQSKVLL 556
Query: 388 VEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTISVDGILTTTGYTQEDYTM 447
++ +D WH V+V I V + I + D ++
Sbjct: 557 F--ISHNTSDGEWHFVEV---------IFAEAVTLTLIDDSCKEKCIAKAPTPLESDQSI 605
Query: 448 LGSDDFFYVGGSP--------STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQG 499
+ F +GG P + + P + +F+GCL+++ N + LE ++
Sbjct: 606 CAFQNSF-LGGLPVGMTSNGVALLNFYNMPSTPSFVGCLQDIKIDWNHITLE--NISSGS 662
Query: 500 DPKMKIHGVVAFKCENVATLD---------------PITFETP---ESFISLPKWNAKKT 541
+K V CE+ +E P +++ T
Sbjct: 663 SLNVKAGCVRKDWCESQPCQSRGRCINLWLSYQCDCHRPYEGPNCLREYVAGRFGQDDST 722
Query: 542 GSISFDF--------------RTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLD 587
G + F RT +P+GL+L Q I+V L+
Sbjct: 723 GYVIFTLDESYGDTISLSMFVRTLQPSGLLLALENSTY--------QYIRV------WLE 768
Query: 588 GHLYLLLDMGSGTIKIKALLKKVNDGEWYHVD----------FQRDGRSGTISVNTLRTP 637
+L S + +K +L NDG + + +Q G IS +T +
Sbjct: 769 RGRLAMLTPNSPKLVVKFVL---NDGNVHLISLKIKPYKIELYQSSQNLGFISASTWK-- 823
Query: 638 YTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYV-GCIRDLFIDGQSKDI 696
++ D +Y+GGLP+ + TE LN G+ GCI+D+ ++ Q+ +
Sbjct: 824 ---------IEKGDVIYIGGLPDKQ-----ETE-----LNGGFFKGCIQDVRLNNQNLEF 864
Query: 697 RQMAEVQSTAGVKPSCSKETA-----KPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRS 751
+ A + P T C SNPC N G+C W+ + C C G++
Sbjct: 865 --FPNPTNNASLNPVLVNVTQGCAGDNSCKSNPCHNGGVCHSRWDDFSCSCPAL-TSGKA 921
Query: 752 CE 753
CE
Sbjct: 922 CE 923
Score = 54.3 bits (129), Expect = 9e-07
Identities = 77/366 (21%), Positives = 135/366 (36%), Gaps = 77/366 (21%)
Query: 54 MSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGA 113
+S ++T GL+L ++ + ++ + L RG L+ L+ +NDG
Sbjct: 739 LSMFVRTLQPSGLLLALENSTY-QYIRVWLERGRLAMLT-----PNSPKLVVKFVLNDGN 792
Query: 114 WHSVRIRRQFRNTTLFIDQVEAKWVEV---KSKRRDMTVFSGLFVGGLPPELRAAALKLT 170
H + ++ + L+ ++ K ++ D+ +++GGLP +
Sbjct: 793 VHLISLKIKPYKIELYQSSQNLGFISASTWKIEKGDV-----IYIGGLPDKQETEL---- 843
Query: 171 LASVREREPFKGWIRDVRVNSSQV--LPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVC 228
FKG I+DVR+N+ + P + L+ N G C + C
Sbjct: 844 -----NGGFFKGCIQDVRLNNQNLEFFPNPTNNASLNPVLVNVTQG--CAGDNSCKSNPC 896
Query: 229 LNGGVCSVVDDQAVCDCSRTGFRGKDCSQEIKF--------GLQCVLPVLLHDNDQGKYC 280
NGGVC D C C GK C +E+++ G QC PVL QG C
Sbjct: 897 HNGGVCHSRWDDFSCSCPAL-TSGKAC-EEVQWCGFSPCPHGAQC-QPVL-----QGFEC 948
Query: 281 CINTAKPLTEKDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNPIQSSSDE 340
N A F G S I
Sbjct: 949 IAN---------------------------------AVFNGQSGQILFRSNGNITRELTN 975
Query: 341 ITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDNAW 400
IT F+T N ++LH K +++N+++++ + + G+ + + + ND W
Sbjct: 976 ITFGFRTRDANVIILHAEKEPEFLNISIQDSRLFFQLQSGNSFYMLSLTSLQ-SVNDGTW 1034
Query: 401 HDVKVT 406
H+V ++
Sbjct: 1035 HEVTLS 1040
Score = 53.9 bits (128), Expect = 1e-06
Identities = 61/226 (26%), Positives = 93/226 (41%), Gaps = 40/226 (17%)
Query: 543 SISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIK 602
+I+F FRT + N +IL + +P +F I + D L+ L G+
Sbjct: 975 NITFGFRTRDANVIILHAEKEP--------------EFLNISIQDSRLFFQLQSGNSFYM 1020
Query: 603 IKAL-LKKVNDGEWYHVDFQR-DGRSGT----ISVNTLRTPYT----APGESEILDLDDE 652
+ L+ VNDG W+ V D S T + V+ TP+ A G L + +
Sbjct: 1021 LSLTSLQSVNDGTWHEVTLSMTDPLSQTSRWQMEVDN-ETPFVTSTIATGSLNFLKDNTD 1079
Query: 653 LYLGGLP-ENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQ----STAG 707
+Y+G +N GL L+ +G I + + I + E Q ST
Sbjct: 1080 IYVGDRAIDNIKGL-------QGCLSTIEIGGIYLSYFENVHGFINKPQEEQFLKISTNS 1132
Query: 708 VKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCE 753
V C + C SNPC + G C D ++ Y C C G+ G+ CE
Sbjct: 1133 VVTGCLQLNV--CNSNPCLHGGNCEDIYSSYHCSCP-LGWSGKHCE 1175
Score = 52.0 bits (123), Expect = 4e-06
Identities = 46/213 (21%), Positives = 87/213 (40%), Gaps = 34/213 (15%)
Query: 968 HLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQ 1027
++ F F+T + +IL+ + +F+ + + L + GN ++ +S + +ND
Sbjct: 975 NITFGFRTRDANVIILHAEKEP-EFLNISIQDSRLFFQLQSGNSFYMLSLTSLQSVNDGT 1033
Query: 1028 WHNVMISRDTSNLHT----VKIDTK---ITTQITAGARN-LDLKSDLYIGGVAKETYKSL 1079
WH V +S T +++D + +T+ I G+ N L +D+Y+G A + K
Sbjct: 1034 WHEVTLSMTDPLSQTSRWQMEVDNETPFVTSTIATGSLNFLKDNTDIYVGDRAIDNIK-- 1091
Query: 1080 PKLVHAKEGFQGCLASVDLNG-------------RLPDLISDALFCNGQIERGCEGPSTT 1126
G QGCL+++++ G P + GC
Sbjct: 1092 --------GLQGCLSTIEIGGIYLSYFENVHGFINKPQEEQFLKISTNSVVTGCL-QLNV 1142
Query: 1127 CQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLC 1159
C + C + G C + + C C + +SG C
Sbjct: 1143 CNSNPCLHGGNCEDIYSSYHCSCPL-GWSGKHC 1174
Score = 50.4 bits (119), Expect = 1e-05
Identities = 18/34 (52%), Positives = 24/34 (70%)
Query: 720 CLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCE 753
C S PC + G+C DG NRY C+C+G+G+ G CE
Sbjct: 266 CASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCE 299
Score = 41.6 bits (96), Expect = 0.006
Identities = 18/43 (41%), Positives = 25/43 (58%), Gaps = 1/43 (2%)
Query: 720 CLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYD 762
C S+PC+N +C+DG + Y C C GY GR C+ E + D
Sbjct: 152 CASSPCQNGAVCQDGIDGYSCFCV-PGYQGRHCDLEVDECASD 193
Score = 40.4 bits (93), Expect = 0.013
Identities = 55/255 (21%), Positives = 96/255 (37%), Gaps = 31/255 (12%)
Query: 22 GCWAELGSGLEFPGAEGQWTRF----PKWNACCESEMSFQLKTRSARGLVLYFDDEGFCD 77
G E+ + L F G W + K + C ++ + +T L+L+ +
Sbjct: 477 GSLCEIATTLSFEGDGFLWVKSGSVTTKGSVC---NIALRFQTVQPMALLLFRSNRDVFV 533
Query: 78 FLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLFID-----Q 132
LEL+ G + LS + L +DG WH V + T ID +
Sbjct: 534 KLELL---SGYIHLSIQVNNQSKVLLFISHNTSDGEWHFVEVIFAEAVTLTLIDDSCKEK 590
Query: 133 VEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALK-LTLASVREREPFKGWIRDVRVNS 191
AK + + F F+GGLP + + + L ++ F G ++D++++
Sbjct: 591 CIAKAPTPLESDQSICAFQNSFLGGLPVGMTSNGVALLNFYNMPSTPSFVGCLQDIKIDW 650
Query: 192 SQVLPVDSGEVKLDDEPPNSGGGSPCEAG----EEGEGGVCLNGGVCSVVDDQAVCDCSR 247
+ + E +SG +AG + E C + G C + CDC R
Sbjct: 651 NHITL----------ENISSGSSLNVKAGCVRKDWCESQPCQSRGRCINLWLSYQCDCHR 700
Query: 248 TGFRGKDCSQEIKFG 262
+ G +C +E G
Sbjct: 701 P-YEGPNCLREYVAG 714
Score = 39.7 bits (91), Expect = 0.023
Identities = 16/34 (47%), Positives = 19/34 (55%), Gaps = 1/34 (2%)
Query: 720 CLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCE 753
C S PC N C+D Y CDC+ G+LG CE
Sbjct: 228 CWSQPCLNGATCQDALGAYFCDCA-PGFLGDHCE 260
Score = 38.5 bits (88), Expect = 0.051
Identities = 21/79 (26%), Positives = 34/79 (43%), Gaps = 5/79 (6%)
Query: 1084 HAKEGFQGCLASVDLNGRLPDLISDALFCN---GQIERGCEGPSTTCQEDSCSNQGVCLQ 1140
H + C ++ ++G D ++ A C G CE CQ C+N C+
Sbjct: 1173 HCELNIDECFSNPCIHGNCSDRVA-AYHCTCEPGYTGVNCEVDIDNCQSHQCANGATCIS 1231
Query: 1141 QWDGFSCDCSMTSFSGPLC 1159
+G+SC C +F+G C
Sbjct: 1232 HTNGYSCLC-FGNFTGKFC 1249
Score = 37.4 bits (85), Expect = 0.11
Identities = 16/42 (38%), Positives = 24/42 (57%), Gaps = 2/42 (4%)
Query: 712 CSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCE 753
C K+ + C S+PC N G+C+D N++ C C + G CE
Sbjct: 1294 CEKDIDE-CASDPCVNGGLCQDLLNKFQCLCD-VAFAGERCE 1333
Score = 37.0 bits (84), Expect = 0.15
Identities = 20/71 (28%), Positives = 33/71 (46%), Gaps = 3/71 (4%)
Query: 1092 CLASVDLNGRLPDLISDALFCN---GQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCD 1148
C + LNG A FC+ G + CE + C C + G+C+ + +SC+
Sbjct: 228 CWSQPCLNGATCQDALGAYFCDCAPGFLGDHCELNTDECASQPCLHGGLCVDGENRYSCN 287
Query: 1149 CSMTSFSGPLC 1159
C+ + F+G C
Sbjct: 288 CTGSGFTGTHC 298
Score = 35.4 bits (80), Expect = 0.43
Identities = 17/43 (39%), Positives = 23/43 (53%), Gaps = 2/43 (4%)
Query: 712 CSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGT-GYLGRSCE 753
C+K + CLSN C+NN C+D C CS T L + C+
Sbjct: 27 CNKNNTR-CLSNSCQNNSTCKDFSKDNDCSCSDTANNLDKDCD 68
Score = 35.4 bits (80), Expect = 0.43
Identities = 16/36 (44%), Positives = 19/36 (52%), Gaps = 1/36 (2%)
Query: 720 CLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCERE 755
C S+PCKN C + RY C C Y G +CE E
Sbjct: 190 CASDPCKNEATCLNEIGRYTCICP-HNYSGVNCELE 224
Score = 33.5 bits (75), Expect = 1.6
Identities = 15/43 (34%), Positives = 24/43 (55%), Gaps = 1/43 (2%)
Query: 214 GSPCEAG-EEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDC 255
G CE +E CL+GG+C +++ C+C+ +GF G C
Sbjct: 256 GDHCELNTDECASQPCLHGGLCVDGENRYSCNCTGSGFTGTHC 298
Score = 33.1 bits (74), Expect = 2.1
Identities = 15/37 (40%), Positives = 19/37 (51%), Gaps = 3/37 (8%)
Query: 719 PCLSNPCKNNGMC--RDGWNRYVCDCSGTGYLGRSCE 753
PC SNPC+ + C G ++C C GY G CE
Sbjct: 73 PCFSNPCQGSATCVNTPGERSFLCKCP-PGYSGTICE 108
Score = 32.3 bits (72), Expect = 3.7
Identities = 16/47 (34%), Positives = 20/47 (42%), Gaps = 1/47 (2%)
Query: 1114 GQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCN 1160
G R CE C C N VC DG+SC C + + G C+
Sbjct: 139 GYAGRFCEIDHDECASSPCQNGAVCQDGIDGYSCFC-VPGYQGRHCD 184
Score = 31.2 bits (69), Expect = 8.1
Identities = 15/40 (37%), Positives = 20/40 (50%), Gaps = 1/40 (2%)
Query: 220 GEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEI 259
G E C NGG C+ + C C R GF G+ C ++I
Sbjct: 1260 GNEKTNLTCYNGGNCTEFQTELKCMC-RPGFTGEWCEKDI 1298
Score = 31.2 bits (69), Expect = 8.1
Identities = 14/40 (35%), Positives = 19/40 (47%), Gaps = 1/40 (2%)
Query: 1120 CEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLC 1159
CE C D C N G+C + F C C + +F+G C
Sbjct: 1294 CEKDIDECASDPCVNGGLCQDLLNKFQCLCDV-AFAGERC 1332
>gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo
sapiens]
Length = 3312
Score = 90.9 bits (224), Expect = 9e-18
Identities = 97/389 (24%), Positives = 154/389 (39%), Gaps = 93/389 (23%)
Query: 512 KCENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAK 571
+CE A P P SF+ + ++S F T + +GL LF +G+ + K
Sbjct: 1512 RCEVAARSFP-----PSSFVMFRGLRQRFHLTLSLSFATVQQSGL-LFYNGR----LNEK 1561
Query: 572 HPQMIKVDFFAIEMLDGHLYLLLDMG-SGTIKIKALLKKVNDGEWYHVDFQRDGRSGTIS 630
H DF A+E++ G + L G S T+ + ++DG+W+ V + + T +
Sbjct: 1562 H------DFLALELVAGQVRLTYSTGESNTVVSPTVPGGLSDGQWHTVHLRYYNKPRTDA 1615
Query: 631 VNTLRTPY---------------------------------TAPGESEILDLDDELYLGG 657
+ + P + LDL L LGG
Sbjct: 1616 LGGAQGPSKDKVAVLSVDDCDVAVALQFGAEIGNYSCAAAGVQTSSKKSLDLTGPLLLGG 1675
Query: 658 ---LPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSK 714
LPEN FP + ++GC+RDL IDG+ D MA + G C
Sbjct: 1676 VPNLPEN-----FPVS------HKDFIGCMRDLHIDGRRVD---MAAFVANNGTMAGCQA 1721
Query: 715 ETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCE---------REATVLSYDGSM 765
+ C S PCKN+G C + W + CDC G+ G+ C+ R LS++
Sbjct: 1722 KLHF-CDSGPCKNSGFCSERWGSFSCDCP-VGFGGKDCQLTMAHPHHFRGNGTLSWNFGS 1779
Query: 766 FMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCI 825
M + +P + L FR++ G+LM + + TL +LD G + +TV
Sbjct: 1780 DMAVSVPWYL-------GLAFRTRATQGVLMQVQAGPHS-TLLCQLDRGLLSVTVTR--- 1828
Query: 826 RINCNSSKGPETLFAGYNLNDNEWHTVRV 854
S + L ++D WH +R+
Sbjct: 1829 ----GSGRASHLLLDQVTVSDGRWHDLRL 1853
Score = 89.0 bits (219), Expect = 3e-17
Identities = 81/341 (23%), Positives = 140/341 (41%), Gaps = 48/341 (14%)
Query: 953 SSYVALATLQAYTSMHLFFQFKTTSLDGLILYNS--GDGNDFIVVELVKGYLHYVFDLGN 1010
SS+V L+ + L F T GL+ YN + +DF+ +ELV G + + G
Sbjct: 1523 SSFVMFRGLRQRFHLTLSLSFATVQQSGLLFYNGRLNEKHDFLALELVAGQVRLTYSTGE 1582
Query: 1011 GANLIKGSSNKPLNDNQWHNVMI-----------------SRDTSNLHTVK-IDTKITTQ 1052
++ + L+D QWH V + S+D + +V D + Q
Sbjct: 1583 SNTVVSPTVPGGLSDGQWHTVHLRYYNKPRTDALGGAQGPSKDKVAVLSVDDCDVAVALQ 1642
Query: 1053 I---------------TAGARNLDLKSDLYIGGVAKETYKSLPK-LVHAKEGFQGCLASV 1096
T+ ++LDL L +GGV +LP+ + + F GC+ +
Sbjct: 1643 FGAEIGNYSCAAAGVQTSSKKSLDLTGPLLLGGVP-----NLPENFPVSHKDFIGCMRDL 1697
Query: 1097 DLNGRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSG 1156
++GR D+ A N GC+ C C N G C ++W FSCDC + F G
Sbjct: 1698 HIDGRRVDMA--AFVANNGTMAGCQAKLHFCDSGPCKNSGFCSERWGSFSCDCPV-GFGG 1754
Query: 1157 PLCNDPGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGD 1216
C +G G +++ + +D + L + F T + VL++V +G
Sbjct: 1755 KDCQLTMAHPHHFRGNGTLSWNF-GSDMAVSVPWYLGLAFRTRATQGVLMQV--QAGPHS 1811
Query: 1217 YLELHIHQGKIGVKFNVGTDDIA-IEESNAIINDGKYHVVR 1256
L + +G + V G+ + + ++DG++H +R
Sbjct: 1812 TLLCQLDRGLLSVTVTRGSGRASHLLLDQVTVSDGRWHDLR 1852
Score = 68.9 bits (167), Expect = 4e-11
Identities = 130/588 (22%), Positives = 215/588 (36%), Gaps = 113/588 (19%)
Query: 228 CLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEIKFGLQCVLPVLLHDNDQGKYCCINTAKP 287
C NGG C+ + C C R F G+DC + + G +CV V + G C
Sbjct: 1444 CRNGGACARREGGYTCVC-RPRFTGEDCELDTEAG-RCVPGVCRN----GGTC------- 1490
Query: 288 LTEKDNNVEGLAHLMMGDQGKSKGKEEYIA--TFKGSEYFCYDLSQNPIQSSSDEITLSF 345
T+ N G G +G +A +F S + + + Q ++LSF
Sbjct: 1491 -TDAPN---GGFRCQCPAGGAFEGPRCEVAARSFPPSSFVMF---RGLRQRFHLTLSLSF 1543
Query: 346 KTLQRNGLMLHTGK---SADYVNLALKNGAVSLVINLGSGAFEALVEP-VNGKFNDNAWH 401
T+Q++GL+ + G+ D++ L L G V L + G +V P V G +D WH
Sbjct: 1544 ATVQQSGLLFYNGRLNEKHDFLALELVAGQVRLTYSTGES--NTVVSPTVPGGLSDGQWH 1601
Query: 402 DVKVTR-NLRQHSGIGHAMVNKLHCSVTISVDGI----------------LTTTGYTQED 444
V + N + +G A +SVD G
Sbjct: 1602 TVHLRYYNKPRTDALGGAQGPSKDKVAVLSVDDCDVAVALQFGAEIGNYSCAAAGVQTSS 1661
Query: 445 YTMLGSDDFFYVGGSPSTADLPGSPVSN-NFMGCLKEVVYKNN--DVRLELSRLAKQGDP 501
L +GG P+ + PVS+ +F+GC++++ D+ ++
Sbjct: 1662 KKSLDLTGPLLLGGVPNLPE--NFPVSHKDFIGCMRDLHIDGRRVDMAAFVANNGTMAGC 1719
Query: 502 KMKIHGVVAFKCENVATLD----------PITFETPESFISLP-----------KWNAKK 540
+ K+H + C+N P+ F + +++ WN
Sbjct: 1720 QAKLHFCDSGPCKNSGFCSERWGSFSCDCPVGFGGKDCQLTMAHPHHFRGNGTLSWNFGS 1779
Query: 541 TGSISFD------FRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLL 594
++S FRT G+++ P H ++ ++ G L + +
Sbjct: 1780 DMAVSVPWYLGLAFRTRATQGVLMQVQAGP-------HSTLL------CQLDRGLLSVTV 1826
Query: 595 DMGSGTIKIKALLK-KVNDGEWY--HVDFQRD--GRSG----TISVNTLRTPYTAPGESE 645
GSG L + V+DG W+ ++ Q + GR G +S++ T SE
Sbjct: 1827 TRGSGRASHLLLDQVTVSDGRWHDLRLELQEEPGGRRGHHVLMVSLDFSLFQDTMAVGSE 1886
Query: 646 ILDLD-DELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQS 704
+ L +L++GGLP A G VGCI+ +++ +
Sbjct: 1887 LQGLKVKQLHVGGLPPGSAEEA----------PQGLVGCIQGVWLGSTPSGSPALLPPSH 1936
Query: 705 TAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSC 752
+P C A C S PC + CRD W + C C GY G C
Sbjct: 1937 RVNAEPGCVVTNA--CASGPCPPHADCRDLWQTFSCTCQ-PGYYGPGC 1981
Score = 62.0 bits (149), Expect = 4e-09
Identities = 121/538 (22%), Positives = 202/538 (37%), Gaps = 112/538 (20%)
Query: 712 CSKET-AKPCLSNPCKNNGMCRDGWN-RYVCDC-SGTGYLGRSCEREATVLSYDGSMFMK 768
C +T A C+ C+N G C D N + C C +G + G CE A S+ S F+
Sbjct: 1470 CELDTEAGRCVPGVCRNGGTCTDAPNGGFRCQCPAGGAFEGPRCEVAAR--SFPPSSFVM 1527
Query: 769 IQ-LPVVMHTEAEDVSLRFRSQRAYGILMAT-TSRDSADTLRLELDAGRVKLTVNLDCIR 826
+ L H +SL F + + G+L + D L LEL AG+V+LT +
Sbjct: 1528 FRGLRQRFHL---TLSLSFATVQQSGLLFYNGRLNEKHDFLALELVAGQVRLTYSTG--- 1581
Query: 827 INCNSSKGPETLFAGYNLNDNEWHTVRV----------------VRRGKSLKLTVDDQQ- 869
N+ P T+ G L+D +WHTV + + K L+VDD
Sbjct: 1582 -ESNTVVSP-TVPGG--LSDGQWHTVHLRYYNKPRTDALGGAQGPSKDKVAVLSVDDCDV 1637
Query: 870 -------AMTGQMAGDHTRLEFHNIETGIITERRYLSSVPS----------NFIGHLQSL 912
A G + ++ + ++ +T L VP+ +FIG ++ L
Sbjct: 1638 AVALQFGAEIGNYSCAAAGVQTSSKKSLDLTGPLLLGGVPNLPENFPVSHKDFIGCMRDL 1697
Query: 913 TFNGMAYIDL----CKNGDIDYCELNARF---------GF-----RNIIAD-PVTFKTKS 953
+G +D+ NG + C+ F GF + D PV F K
Sbjct: 1698 HIDGRR-VDMAAFVANNGTMAGCQAKLHFCDSGPCKNSGFCSERWGSFSCDCPVGFGGKD 1756
Query: 954 SYVALA-----------------TLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVE 996
+ +A + +L F+T + G+++ + ++ +
Sbjct: 1757 CQLTMAHPHHFRGNGTLSWNFGSDMAVSVPWYLGLAFRTRATQGVLMQVQAGPHSTLLCQ 1816
Query: 997 LVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMI-------SRDTSNLHTVKIDTKI 1049
L +G L G+G ++D +WH++ + R ++ V +D +
Sbjct: 1817 LDRGLLSVTVTRGSGRASHLLLDQVTVSDGRWHDLRLELQEEPGGRRGHHVLMVSLDFSL 1876
Query: 1050 ---TTQITAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGR---LP 1103
T + + + L +K L++GG+ + + P +G GC+ V L P
Sbjct: 1877 FQDTMAVGSELQGLKVK-QLHVGGLPPGSAEEAP------QGLVGCIQGVWLGSTPSGSP 1929
Query: 1104 DLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCND 1161
L+ + N E GC + C C C W FSC C + GP C D
Sbjct: 1930 ALLPPSHRVNA--EPGCV-VTNACASGPCPPHADCRDLWQTFSCTC-QPGYYGPGCVD 1983
Score = 41.2 bits (95), Expect = 0.008
Identities = 36/172 (20%), Positives = 69/172 (40%), Gaps = 36/172 (20%)
Query: 1120 CEGPSTTCQEDSCSNQGVCLQQWDGFSC---------DCSMTSFSG----PLCNDPGTTY 1166
CE C + C N G C ++ G++C DC + + +G +C + GT
Sbjct: 1432 CETELDLCYSNPCRNGGACARREGGYTCVCRPRFTGEDCELDTEAGRCVPGVCRNGGTCT 1491
Query: 1167 IFSKGGGQ----------------ITYKWPPNDRPSTRADR------LAIGFSTVQKEAV 1204
GG + +PP+ R R L++ F+TVQ+ +
Sbjct: 1492 DAPNGGFRCQCPAGGAFEGPRCEVAARSFPPSSFVMFRGLRQRFHLTLSLSFATVQQSGL 1551
Query: 1205 LVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEES-NAIINDGKYHVV 1255
L + D+L L + G++ + ++ G + + + ++DG++H V
Sbjct: 1552 LFYNGRLNEKHDFLALELVAGQVRLTYSTGESNTVVSPTVPGGLSDGQWHTV 1603
Score = 39.3 bits (90), Expect = 0.030
Identities = 57/218 (26%), Positives = 86/218 (39%), Gaps = 62/218 (28%)
Query: 77 DFLELILTRGGRLQLSFSIFCAEPATLLADTP---VNDGAWHSVRIRRQFRNTT------ 127
DFL L L G+++L++S E T+++ T ++DG WH+V +R + T
Sbjct: 1563 DFLALELV-AGQVRLTYST--GESNTVVSPTVPGGLSDGQWHTVHLRYYNKPRTDALGGA 1619
Query: 128 ----------LFIDQVE-----------------AKWVEVKSKRRDMTVFSGLFVGGLP- 159
L +D + A V+ SK+ + + L +GG+P
Sbjct: 1620 QGPSKDKVAVLSVDDCDVAVALQFGAEIGNYSCAAAGVQTSSKK-SLDLTGPLLLGGVPN 1678
Query: 160 -PELRAAALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCE 218
PE + K F G +RD L +D V + N+G + C+
Sbjct: 1679 LPENFPVSHK----------DFIGCMRD--------LHIDGRRVDMAAFVANNGTMAGCQ 1720
Query: 219 AGEEG-EGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDC 255
A + G C N G CS CDC GF GKDC
Sbjct: 1721 AKLHFCDSGPCKNSGFCSERWGSFSCDCP-VGFGGKDC 1757
>gi|157419126 laminin, alpha 4 isoform 2 precursor [Homo sapiens]
Length = 1816
Score = 87.4 bits (215), Expect = 1e-16
Identities = 163/849 (19%), Positives = 315/849 (37%), Gaps = 136/849 (16%)
Query: 319 FKGSEYFCY-DLSQNPIQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVI 377
F GS Y D+++ + +T NGL+L + + L ++NG + +
Sbjct: 1045 FDGSGYAVVRDITRRGKFGQVTRFDIEVRTPADNGLILLMVNGSMFFRLEMRNGYLHVFY 1104
Query: 378 NLGSGAFEALVEPV--NGKFNDNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTISVDGIL 435
+ G +E + ND +H++ + + + + +V++ H S+D
Sbjct: 1105 DFGFSGGPVHLEDTLKKAQINDAKYHEISIIYHNDKKMIL---VVDRRHVK---SMDNEK 1158
Query: 436 TTTGYTQEDYTMLGSDDFFYVGGSP-----STADLPGSPVSNNFMGCLKEVVYKNNDVRL 490
+T Y+GG+P S A P+ NF GC+K ++ D L
Sbjct: 1159 MKIPFTD-----------IYIGGAPPEILQSRALRAHLPLDINFRGCMKGFQFQKKDFNL 1207
Query: 491 ELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPESFI-SLPKWNAKKTGSISFDFR 549
L + G V + C + + + +SFI S+ K + F+FR
Sbjct: 1208 -LEQTETLG---------VGYGCPEDSLISRRAYFNGQSFIASIQKISFFDGFEGGFNFR 1257
Query: 550 TTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKK 609
T +PNGL+ + D F+I + +G + ++D+ IK++++ K+
Sbjct: 1258 TLQPNGLLFYYASGS--------------DVFSISLDNGTV--IMDVKG--IKVQSVDKQ 1299
Query: 610 VNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDL---DDELYLGGLPENKAGLV 666
NDG + V + V+ R P + +I + + Y GG P
Sbjct: 1300 YNDGLSHFVISSVSPTRYELIVDKSRVGSKNPTKGKIEQTQASEKKFYFGGSP------- 1352
Query: 667 FPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSC-------------- 712
+ + GCI + + +D+ + T V S
Sbjct: 1353 ------ISAQYANFTGCISNAYFTRVDRDVEVEDFQRYTEKVHTSLYECPIESSPLFLLH 1406
Query: 713 --SKETAKPCLSNPCKNNGMCRDG--WNRYVCDCSGTG-------YLGRSCEREATVLSY 761
K +KP S K G +D W+ +L S Y
Sbjct: 1407 KKGKNLSKPKASQN-KKGGKSKDAPSWDPVALKLPERNTPRNSHCHLSNSPRAIEHAYQY 1465
Query: 762 DGSMFMKIQLPVVMHTEAE-----DVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRV 816
G+ + + H + + S+R R++ ++G++ + ++ D + L L GR+
Sbjct: 1466 GGTANSRQEFE---HLKGDFGAKSQFSIRLRTRSSHGMIFYVSDQEENDFMTLFLAHGRL 1522
Query: 817 KLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMA 876
N+ ++ S + ND WH V +R S +L +D + + +
Sbjct: 1523 VYMFNVGHKKLKIRSQE---------KYNDGLWHDVIFIRERSSGRLVIDGLRVLEESLP 1573
Query: 877 GDHTRLEFHN-IETGIITERRYLSSVPSN----FIGHLQSLTFNGMAYIDLCKNGDIDYC 931
+ I G + + + +V N F G L +L NG + + + C
Sbjct: 1574 PTEATWKIKGPIYLGGVAPGKAVKNVQINSIYSFSGCLSNLQLNGASITSASQTFSVTPC 1633
Query: 932 ELNARFGFRNIIADPVTFKTKSSYVAL-ATLQAYTSMHLFFQFKTTSLDGLILYNSGDGN 990
F + F T+ YV L + + F+ + S G +++
Sbjct: 1634 -------FEGPMETGTYFSTEGGYVVLDESFNIGLKFEIAFEVRPRSSSGTLVHGHSVNG 1686
Query: 991 DFIVVELVKGYLHYVFDLGNGANLIKGS--SNKPLNDNQWHNVMISRDTSNLHTVKIDTK 1048
+++ V + G + + + NG S + L D +WH + + RD SN+ + +D++
Sbjct: 1687 EYLNVHMKNGQV--IVKVNNGIRDFSTSVTPKQSLCDGRWHRITVIRD-SNVVQLDVDSE 1743
Query: 1049 ITTQI-TAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLIS 1107
+ + + +D + +++GGV + P+L +K F GC+ ++G P S
Sbjct: 1744 VNHVVGPLNPKPIDHREPVFVGGVPESLL--TPRLAPSKP-FTGCIRHFVIDGH-PVSFS 1799
Query: 1108 DALFCNGQI 1116
A +G +
Sbjct: 1800 KAALVSGAV 1808
Score = 56.2 bits (134), Expect = 2e-07
Identities = 86/370 (23%), Positives = 141/370 (38%), Gaps = 46/370 (12%)
Query: 362 DYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIG-HAMV 420
+Y+ LA+KN + V NLG+ E ++ + VK+ R +G H V
Sbjct: 886 EYMGLAIKNDNLVYVYNLGTKDVEIPLDSKPVSSWPAYFSIVKIER-------VGKHGKV 938
Query: 421 NKLHCSVTISVDGILTTTGYTQEDYTMLG---SDDFFYVGGSPSTADLPGSPVSNNFMGC 477
S++ + + G D ++L D FYVGG PS LP S F+GC
Sbjct: 939 FLTVPSLSSTAEEKFIKKGEFSGDDSLLDLDPEDTVFYVGGVPSNFKLPTSLNLPGFVGC 998
Query: 478 LKEVVYKNNDVRLELSRLAKQGDPKMKI---HGVVAFKCENVAT--LDPITFETPESFIS 532
L+ N+ + L + DP + +AF A+ D +
Sbjct: 999 LELATLNNDVISLYNFKHIYNMDPSTSVPCARDKLAFTQSRAASYFFDGSGYAVVRDITR 1058
Query: 533 LPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYL 592
K+ + + RT NGLIL FF +EM +G+L++
Sbjct: 1059 RGKFG--QVTRFDIEVRTPADNGLILLMVNGSM--------------FFRLEMRNGYLHV 1102
Query: 593 LLDMG--SGTIKIKALLKK--VNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILD 648
D G G + ++ LKK +ND +++ + I V R + E +
Sbjct: 1103 FYDFGFSGGPVHLEDTLKKAQINDAKYHEISIIYHNDKKMILVVDRRHVKSMDNEKMKIP 1162
Query: 649 LDDELYLGGLPENKAGLVFPTEVWTA--LLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTA 706
D +Y+GG P + + A L+ + GC++ Q KD + E T
Sbjct: 1163 FTD-IYIGGAPPE----ILQSRALRAHLPLDINFRGCMKG--FQFQKKDF-NLLEQTETL 1214
Query: 707 GVKPSCSKET 716
GV C +++
Sbjct: 1215 GVGYGCPEDS 1224
Score = 50.1 bits (118), Expect = 2e-05
Identities = 35/144 (24%), Positives = 68/144 (47%), Gaps = 7/144 (4%)
Query: 51 ESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVN 110
+S+ S +L+TRS+ G++ Y D+ DF+ L L GRL F++ + + + N
Sbjct: 1485 KSQFSIRLRTRSSHGMIFYVSDQEENDFMTLFLAH-GRLVYMFNV-GHKKLKIRSQEKYN 1542
Query: 111 DGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLT 170
DG WH V R+ + L ID + + + +++GG+ P A +
Sbjct: 1543 DGLWHDVIFIRERSSGRLVIDGLRVLEESLPPTEATWKIKGPIYLGGVAP--GKAVKNVQ 1600
Query: 171 LASVREREPFKGWIRDVRVNSSQV 194
+ S+ F G + ++++N + +
Sbjct: 1601 INSIYS---FSGCLSNLQLNGASI 1621
Score = 47.8 bits (112), Expect = 8e-05
Identities = 145/764 (18%), Positives = 275/764 (35%), Gaps = 143/764 (18%)
Query: 577 KVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYH--VDFQRDGRSGTISVNTL 634
K ++ + + + +L + ++G+ ++I K V+ Y V +R G+ G + +
Sbjct: 884 KKEYMGLAIKNDNLVYVYNLGTKDVEIPLDSKPVSSWPAYFSIVKIERVGKHGKVFLTVP 943
Query: 635 RTPYTAP----------GESEILDLDDE---LYLGGLPENKAGLVFPTEVWTALLNYGYV 681
TA G+ +LDLD E Y+GG+P N ++ T+L G+V
Sbjct: 944 SLSSTAEEKFIKKGEFSGDDSLLDLDPEDTVFYVGGVPSN-------FKLPTSLNLPGFV 996
Query: 682 GCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCD 741
GC+ + + D+ + + + PS S A+ L+ + Y D
Sbjct: 997 GCLE---LATLNNDVISLYNFKHIYNMDPSTSVPCARDKLA-------FTQSRAASYFFD 1046
Query: 742 CSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSR 801
G+GY + R+ T G + D+ +R + +LM S
Sbjct: 1047 --GSGY---AVVRDITRRGKFGQV------------TRFDIEVRTPADNGLILLMVNGSM 1089
Query: 802 DSADTLRLELDAGRVKLTVNLDCIRINCNSSKGP---ETLFAGYNLNDNEWHTVRVV-RR 857
RLE+ G + + + S GP E +ND ++H + ++
Sbjct: 1090 ----FFRLEMRNGYLHVFYDF-------GFSGGPVHLEDTLKKAQINDAKYHEISIIYHN 1138
Query: 858 GKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETG-----IITERRYLSSVPS--NFIGHLQ 910
K + L VD + + M + ++ F +I G I+ R + +P NF G ++
Sbjct: 1139 DKKMILVVDRRHVKS--MDNEKMKIPFTDIYIGGAPPEILQSRALRAHLPLDINFRGCMK 1196
Query: 911 SLTFNGMAYIDLCKNGDIDYCELNARFGFR------NIIADPVTFKTKSSYVALATLQAY 964
F + D + E G ++I+ F +S ++ + +
Sbjct: 1197 GFQF---------QKKDFNLLEQTETLGVGYGCPEDSLISRRAYFNGQSFIASIQKISFF 1247
Query: 965 TSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLN 1024
F F+T +GL+ Y + G+D + L G + + D+ + S +K N
Sbjct: 1248 DGFEGGFNFRTLQPNGLLFYYAS-GSDVFSISLDNGTV--IMDV---KGIKVQSVDKQYN 1301
Query: 1025 DNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLPKLVH 1084
D H V+ S + + +++ G++N K+ Y +
Sbjct: 1302 DGLSHFVISSVSPTRYELIVDKSRV------GSKNPTKGKIEQTQASEKKFYFGGSPISA 1355
Query: 1085 AKEGFQGCLAS-----VDLNGRLPD----------------LISDALFCNGQIERGCEGP 1123
F GC+++ VD + + D + S LF + + P
Sbjct: 1356 QYANFTGCISNAYFTRVDRDVEVEDFQRYTEKVHTSLYECPIESSPLFLLHKKGKNLSKP 1415
Query: 1124 STTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQI---TYKWP 1180
+ + ++ WD + P N P ++ + Y++
Sbjct: 1416 KASQNKKGGKSKDA--PSWDPVALKL-------PERNTPRNSHCHLSNSPRAIEHAYQYG 1466
Query: 1181 PNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGL---------GDYLELHIHQGKIGVKF 1231
+ L F + ++ +R SS G+ D++ L + G++ F
Sbjct: 1467 GTANSRQEFEHLKGDFGAKSQFSIRLRTRSSHGMIFYVSDQEENDFMTLFLAHGRLVYMF 1526
Query: 1232 NVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIE 1275
NVG + I S NDG +H V F R + L +D V+E
Sbjct: 1527 NVGHKKLKIR-SQEKYNDGLWHDVIFIRERSSGRLVIDGLRVLE 1569
Score = 47.4 bits (111), Expect = 1e-04
Identities = 71/390 (18%), Positives = 140/390 (35%), Gaps = 74/390 (18%)
Query: 337 SSDEITLSFKTLQRNGLMLHTG--KSADYVNLALKNGAVSLVINLGSGAFEALVEPVNGK 394
+ + ++ +T +G++ + + D++ L L +G + + N+G + + K
Sbjct: 1484 AKSQFSIRLRTRSSHGMIFYVSDQEENDFMTLFLAHGRLVYMFNVGHKKLKIRSQE---K 1540
Query: 395 FNDNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTISVDGILT---TTGYTQEDYTMLGSD 451
+ND WHDV R S + +DG+ + T+ + + G
Sbjct: 1541 YNDGLWHDVIFIRE---------------RSSGRLVIDGLRVLEESLPPTEATWKIKGP- 1584
Query: 452 DFFYVGGSPSTADLPGSPVSN-------NFMGCLKEVVYKNNDVRLELSRLAKQGDPKMK 504
Y+GG PG V N +F GCL + + +
Sbjct: 1585 --IYLGGVA-----PGKAVKNVQINSIYSFSGCLSNLQLNGASITSASQTFS-------- 1629
Query: 505 IHGVVAFKCENVATLDPITFETPESFISLPK-WNAKKTGSISFDFRTTEPNGLILFSHGK 563
C F T ++ L + +N I+F+ R +G ++ H
Sbjct: 1630 -----VTPCFEGPMETGTYFSTEGGYVVLDESFNIGLKFEIAFEVRPRSSSGTLVHGHS- 1683
Query: 564 PRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKK-VNDGEWYHVDFQR 622
+ ++ + M +G + + ++ G K+ + DG W+ + R
Sbjct: 1684 ------------VNGEYLNVHMKNGQVIVKVNNGIRDFSTSVTPKQSLCDGRWHRITVIR 1731
Query: 623 DGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVG 682
D + V++ P + +D + +++GG+PE+ L+ P + + G
Sbjct: 1732 DSNVVQLDVDSEVNHVVGPLNPKPIDHREPVFVGGVPES---LLTP----RLAPSKPFTG 1784
Query: 683 CIRDLFIDGQSKDIRQMAEVQSTAGVKPSC 712
CIR IDG + A V + SC
Sbjct: 1785 CIRHFVIDGHPVSFSKAALVSGAVSIN-SC 1813
Score = 35.8 bits (81), Expect = 0.33
Identities = 37/142 (26%), Positives = 61/142 (42%), Gaps = 21/142 (14%)
Query: 35 GAEGQWTRFPKWNACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFS 94
G GQ TRF +++T + GL+L + LE+ R G L + +
Sbjct: 1060 GKFGQVTRF-----------DIEVRTPADNGLILLMVNGSMFFRLEM---RNGYLHVFYD 1105
Query: 95 I-FCAEPATL---LADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVF 150
F P L L +ND +H + I + N I V+ + V+ + F
Sbjct: 1106 FGFSGGPVHLEDTLKKAQINDAKYHEISII--YHNDKKMILVVDRRHVKSMDNEKMKIPF 1163
Query: 151 SGLFVGGLPPE-LRAAALKLTL 171
+ +++GG PPE L++ AL+ L
Sbjct: 1164 TDIYIGGAPPEILQSRALRAHL 1185
>gi|157419124 laminin, alpha 4 isoform 1 precursor [Homo sapiens]
Length = 1823
Score = 87.4 bits (215), Expect = 1e-16
Identities = 163/849 (19%), Positives = 315/849 (37%), Gaps = 136/849 (16%)
Query: 319 FKGSEYFCY-DLSQNPIQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVI 377
F GS Y D+++ + +T NGL+L + + L ++NG + +
Sbjct: 1052 FDGSGYAVVRDITRRGKFGQVTRFDIEVRTPADNGLILLMVNGSMFFRLEMRNGYLHVFY 1111
Query: 378 NLGSGAFEALVEPV--NGKFNDNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTISVDGIL 435
+ G +E + ND +H++ + + + + +V++ H S+D
Sbjct: 1112 DFGFSGGPVHLEDTLKKAQINDAKYHEISIIYHNDKKMIL---VVDRRHVK---SMDNEK 1165
Query: 436 TTTGYTQEDYTMLGSDDFFYVGGSP-----STADLPGSPVSNNFMGCLKEVVYKNNDVRL 490
+T Y+GG+P S A P+ NF GC+K ++ D L
Sbjct: 1166 MKIPFTD-----------IYIGGAPPEILQSRALRAHLPLDINFRGCMKGFQFQKKDFNL 1214
Query: 491 ELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPESFI-SLPKWNAKKTGSISFDFR 549
L + G V + C + + + +SFI S+ K + F+FR
Sbjct: 1215 -LEQTETLG---------VGYGCPEDSLISRRAYFNGQSFIASIQKISFFDGFEGGFNFR 1264
Query: 550 TTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKK 609
T +PNGL+ + D F+I + +G + ++D+ IK++++ K+
Sbjct: 1265 TLQPNGLLFYYASGS--------------DVFSISLDNGTV--IMDVKG--IKVQSVDKQ 1306
Query: 610 VNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDL---DDELYLGGLPENKAGLV 666
NDG + V + V+ R P + +I + + Y GG P
Sbjct: 1307 YNDGLSHFVISSVSPTRYELIVDKSRVGSKNPTKGKIEQTQASEKKFYFGGSP------- 1359
Query: 667 FPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSC-------------- 712
+ + GCI + + +D+ + T V S
Sbjct: 1360 ------ISAQYANFTGCISNAYFTRVDRDVEVEDFQRYTEKVHTSLYECPIESSPLFLLH 1413
Query: 713 --SKETAKPCLSNPCKNNGMCRDG--WNRYVCDCSGTG-------YLGRSCEREATVLSY 761
K +KP S K G +D W+ +L S Y
Sbjct: 1414 KKGKNLSKPKASQN-KKGGKSKDAPSWDPVALKLPERNTPRNSHCHLSNSPRAIEHAYQY 1472
Query: 762 DGSMFMKIQLPVVMHTEAE-----DVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRV 816
G+ + + H + + S+R R++ ++G++ + ++ D + L L GR+
Sbjct: 1473 GGTANSRQEFE---HLKGDFGAKSQFSIRLRTRSSHGMIFYVSDQEENDFMTLFLAHGRL 1529
Query: 817 KLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMA 876
N+ ++ S + ND WH V +R S +L +D + + +
Sbjct: 1530 VYMFNVGHKKLKIRSQE---------KYNDGLWHDVIFIRERSSGRLVIDGLRVLEESLP 1580
Query: 877 GDHTRLEFHN-IETGIITERRYLSSVPSN----FIGHLQSLTFNGMAYIDLCKNGDIDYC 931
+ I G + + + +V N F G L +L NG + + + C
Sbjct: 1581 PTEATWKIKGPIYLGGVAPGKAVKNVQINSIYSFSGCLSNLQLNGASITSASQTFSVTPC 1640
Query: 932 ELNARFGFRNIIADPVTFKTKSSYVAL-ATLQAYTSMHLFFQFKTTSLDGLILYNSGDGN 990
F + F T+ YV L + + F+ + S G +++
Sbjct: 1641 -------FEGPMETGTYFSTEGGYVVLDESFNIGLKFEIAFEVRPRSSSGTLVHGHSVNG 1693
Query: 991 DFIVVELVKGYLHYVFDLGNGANLIKGS--SNKPLNDNQWHNVMISRDTSNLHTVKIDTK 1048
+++ V + G + + + NG S + L D +WH + + RD SN+ + +D++
Sbjct: 1694 EYLNVHMKNGQV--IVKVNNGIRDFSTSVTPKQSLCDGRWHRITVIRD-SNVVQLDVDSE 1750
Query: 1049 ITTQI-TAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLIS 1107
+ + + +D + +++GGV + P+L +K F GC+ ++G P S
Sbjct: 1751 VNHVVGPLNPKPIDHREPVFVGGVPESLL--TPRLAPSKP-FTGCIRHFVIDGH-PVSFS 1806
Query: 1108 DALFCNGQI 1116
A +G +
Sbjct: 1807 KAALVSGAV 1815
Score = 56.2 bits (134), Expect = 2e-07
Identities = 86/370 (23%), Positives = 141/370 (38%), Gaps = 46/370 (12%)
Query: 362 DYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIG-HAMV 420
+Y+ LA+KN + V NLG+ E ++ + VK+ R +G H V
Sbjct: 893 EYMGLAIKNDNLVYVYNLGTKDVEIPLDSKPVSSWPAYFSIVKIER-------VGKHGKV 945
Query: 421 NKLHCSVTISVDGILTTTGYTQEDYTMLG---SDDFFYVGGSPSTADLPGSPVSNNFMGC 477
S++ + + G D ++L D FYVGG PS LP S F+GC
Sbjct: 946 FLTVPSLSSTAEEKFIKKGEFSGDDSLLDLDPEDTVFYVGGVPSNFKLPTSLNLPGFVGC 1005
Query: 478 LKEVVYKNNDVRLELSRLAKQGDPKMKI---HGVVAFKCENVAT--LDPITFETPESFIS 532
L+ N+ + L + DP + +AF A+ D +
Sbjct: 1006 LELATLNNDVISLYNFKHIYNMDPSTSVPCARDKLAFTQSRAASYFFDGSGYAVVRDITR 1065
Query: 533 LPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYL 592
K+ + + RT NGLIL FF +EM +G+L++
Sbjct: 1066 RGKFG--QVTRFDIEVRTPADNGLILLMVNGSM--------------FFRLEMRNGYLHV 1109
Query: 593 LLDMG--SGTIKIKALLKK--VNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILD 648
D G G + ++ LKK +ND +++ + I V R + E +
Sbjct: 1110 FYDFGFSGGPVHLEDTLKKAQINDAKYHEISIIYHNDKKMILVVDRRHVKSMDNEKMKIP 1169
Query: 649 LDDELYLGGLPENKAGLVFPTEVWTA--LLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTA 706
D +Y+GG P + + A L+ + GC++ Q KD + E T
Sbjct: 1170 FTD-IYIGGAPPE----ILQSRALRAHLPLDINFRGCMKG--FQFQKKDF-NLLEQTETL 1221
Query: 707 GVKPSCSKET 716
GV C +++
Sbjct: 1222 GVGYGCPEDS 1231
Score = 50.1 bits (118), Expect = 2e-05
Identities = 35/144 (24%), Positives = 68/144 (47%), Gaps = 7/144 (4%)
Query: 51 ESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVN 110
+S+ S +L+TRS+ G++ Y D+ DF+ L L GRL F++ + + + N
Sbjct: 1492 KSQFSIRLRTRSSHGMIFYVSDQEENDFMTLFLAH-GRLVYMFNV-GHKKLKIRSQEKYN 1549
Query: 111 DGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLT 170
DG WH V R+ + L ID + + + +++GG+ P A +
Sbjct: 1550 DGLWHDVIFIRERSSGRLVIDGLRVLEESLPPTEATWKIKGPIYLGGVAP--GKAVKNVQ 1607
Query: 171 LASVREREPFKGWIRDVRVNSSQV 194
+ S+ F G + ++++N + +
Sbjct: 1608 INSIYS---FSGCLSNLQLNGASI 1628
Score = 47.8 bits (112), Expect = 8e-05
Identities = 145/764 (18%), Positives = 275/764 (35%), Gaps = 143/764 (18%)
Query: 577 KVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYH--VDFQRDGRSGTISVNTL 634
K ++ + + + +L + ++G+ ++I K V+ Y V +R G+ G + +
Sbjct: 891 KKEYMGLAIKNDNLVYVYNLGTKDVEIPLDSKPVSSWPAYFSIVKIERVGKHGKVFLTVP 950
Query: 635 RTPYTAP----------GESEILDLDDE---LYLGGLPENKAGLVFPTEVWTALLNYGYV 681
TA G+ +LDLD E Y+GG+P N ++ T+L G+V
Sbjct: 951 SLSSTAEEKFIKKGEFSGDDSLLDLDPEDTVFYVGGVPSN-------FKLPTSLNLPGFV 1003
Query: 682 GCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCD 741
GC+ + + D+ + + + PS S A+ L+ + Y D
Sbjct: 1004 GCLE---LATLNNDVISLYNFKHIYNMDPSTSVPCARDKLA-------FTQSRAASYFFD 1053
Query: 742 CSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSR 801
G+GY + R+ T G + D+ +R + +LM S
Sbjct: 1054 --GSGY---AVVRDITRRGKFGQV------------TRFDIEVRTPADNGLILLMVNGSM 1096
Query: 802 DSADTLRLELDAGRVKLTVNLDCIRINCNSSKGP---ETLFAGYNLNDNEWHTVRVV-RR 857
RLE+ G + + + S GP E +ND ++H + ++
Sbjct: 1097 ----FFRLEMRNGYLHVFYDF-------GFSGGPVHLEDTLKKAQINDAKYHEISIIYHN 1145
Query: 858 GKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETG-----IITERRYLSSVPS--NFIGHLQ 910
K + L VD + + M + ++ F +I G I+ R + +P NF G ++
Sbjct: 1146 DKKMILVVDRRHVKS--MDNEKMKIPFTDIYIGGAPPEILQSRALRAHLPLDINFRGCMK 1203
Query: 911 SLTFNGMAYIDLCKNGDIDYCELNARFGFR------NIIADPVTFKTKSSYVALATLQAY 964
F + D + E G ++I+ F +S ++ + +
Sbjct: 1204 GFQF---------QKKDFNLLEQTETLGVGYGCPEDSLISRRAYFNGQSFIASIQKISFF 1254
Query: 965 TSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLN 1024
F F+T +GL+ Y + G+D + L G + + D+ + S +K N
Sbjct: 1255 DGFEGGFNFRTLQPNGLLFYYAS-GSDVFSISLDNGTV--IMDV---KGIKVQSVDKQYN 1308
Query: 1025 DNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLPKLVH 1084
D H V+ S + + +++ G++N K+ Y +
Sbjct: 1309 DGLSHFVISSVSPTRYELIVDKSRV------GSKNPTKGKIEQTQASEKKFYFGGSPISA 1362
Query: 1085 AKEGFQGCLAS-----VDLNGRLPD----------------LISDALFCNGQIERGCEGP 1123
F GC+++ VD + + D + S LF + + P
Sbjct: 1363 QYANFTGCISNAYFTRVDRDVEVEDFQRYTEKVHTSLYECPIESSPLFLLHKKGKNLSKP 1422
Query: 1124 STTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQI---TYKWP 1180
+ + ++ WD + P N P ++ + Y++
Sbjct: 1423 KASQNKKGGKSKDA--PSWDPVALKL-------PERNTPRNSHCHLSNSPRAIEHAYQYG 1473
Query: 1181 PNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGL---------GDYLELHIHQGKIGVKF 1231
+ L F + ++ +R SS G+ D++ L + G++ F
Sbjct: 1474 GTANSRQEFEHLKGDFGAKSQFSIRLRTRSSHGMIFYVSDQEENDFMTLFLAHGRLVYMF 1533
Query: 1232 NVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIE 1275
NVG + I S NDG +H V F R + L +D V+E
Sbjct: 1534 NVGHKKLKIR-SQEKYNDGLWHDVIFIRERSSGRLVIDGLRVLE 1576
Score = 47.4 bits (111), Expect = 1e-04
Identities = 71/390 (18%), Positives = 140/390 (35%), Gaps = 74/390 (18%)
Query: 337 SSDEITLSFKTLQRNGLMLHTG--KSADYVNLALKNGAVSLVINLGSGAFEALVEPVNGK 394
+ + ++ +T +G++ + + D++ L L +G + + N+G + + K
Sbjct: 1491 AKSQFSIRLRTRSSHGMIFYVSDQEENDFMTLFLAHGRLVYMFNVGHKKLKIRSQE---K 1547
Query: 395 FNDNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTISVDGILT---TTGYTQEDYTMLGSD 451
+ND WHDV R S + +DG+ + T+ + + G
Sbjct: 1548 YNDGLWHDVIFIRE---------------RSSGRLVIDGLRVLEESLPPTEATWKIKGP- 1591
Query: 452 DFFYVGGSPSTADLPGSPVSN-------NFMGCLKEVVYKNNDVRLELSRLAKQGDPKMK 504
Y+GG PG V N +F GCL + + +
Sbjct: 1592 --IYLGGVA-----PGKAVKNVQINSIYSFSGCLSNLQLNGASITSASQTFS-------- 1636
Query: 505 IHGVVAFKCENVATLDPITFETPESFISLPK-WNAKKTGSISFDFRTTEPNGLILFSHGK 563
C F T ++ L + +N I+F+ R +G ++ H
Sbjct: 1637 -----VTPCFEGPMETGTYFSTEGGYVVLDESFNIGLKFEIAFEVRPRSSSGTLVHGHS- 1690
Query: 564 PRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKK-VNDGEWYHVDFQR 622
+ ++ + M +G + + ++ G K+ + DG W+ + R
Sbjct: 1691 ------------VNGEYLNVHMKNGQVIVKVNNGIRDFSTSVTPKQSLCDGRWHRITVIR 1738
Query: 623 DGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVG 682
D + V++ P + +D + +++GG+PE+ L+ P + + G
Sbjct: 1739 DSNVVQLDVDSEVNHVVGPLNPKPIDHREPVFVGGVPES---LLTP----RLAPSKPFTG 1791
Query: 683 CIRDLFIDGQSKDIRQMAEVQSTAGVKPSC 712
CIR IDG + A V + SC
Sbjct: 1792 CIRHFVIDGHPVSFSKAALVSGAVSIN-SC 1820
Score = 35.8 bits (81), Expect = 0.33
Identities = 37/142 (26%), Positives = 61/142 (42%), Gaps = 21/142 (14%)
Query: 35 GAEGQWTRFPKWNACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFS 94
G GQ TRF +++T + GL+L + LE+ R G L + +
Sbjct: 1067 GKFGQVTRF-----------DIEVRTPADNGLILLMVNGSMFFRLEM---RNGYLHVFYD 1112
Query: 95 I-FCAEPATL---LADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVF 150
F P L L +ND +H + I + N I V+ + V+ + F
Sbjct: 1113 FGFSGGPVHLEDTLKKAQINDAKYHEISII--YHNDKKMILVVDRRHVKSMDNEKMKIPF 1170
Query: 151 SGLFVGGLPPE-LRAAALKLTL 171
+ +++GG PPE L++ AL+ L
Sbjct: 1171 TDIYIGGAPPEILQSRALRAHL 1192
>gi|157419122 laminin, alpha 4 isoform 2 precursor [Homo sapiens]
Length = 1816
Score = 87.4 bits (215), Expect = 1e-16
Identities = 163/849 (19%), Positives = 315/849 (37%), Gaps = 136/849 (16%)
Query: 319 FKGSEYFCY-DLSQNPIQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVI 377
F GS Y D+++ + +T NGL+L + + L ++NG + +
Sbjct: 1045 FDGSGYAVVRDITRRGKFGQVTRFDIEVRTPADNGLILLMVNGSMFFRLEMRNGYLHVFY 1104
Query: 378 NLGSGAFEALVEPV--NGKFNDNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTISVDGIL 435
+ G +E + ND +H++ + + + + +V++ H S+D
Sbjct: 1105 DFGFSGGPVHLEDTLKKAQINDAKYHEISIIYHNDKKMIL---VVDRRHVK---SMDNEK 1158
Query: 436 TTTGYTQEDYTMLGSDDFFYVGGSP-----STADLPGSPVSNNFMGCLKEVVYKNNDVRL 490
+T Y+GG+P S A P+ NF GC+K ++ D L
Sbjct: 1159 MKIPFTD-----------IYIGGAPPEILQSRALRAHLPLDINFRGCMKGFQFQKKDFNL 1207
Query: 491 ELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPESFI-SLPKWNAKKTGSISFDFR 549
L + G V + C + + + +SFI S+ K + F+FR
Sbjct: 1208 -LEQTETLG---------VGYGCPEDSLISRRAYFNGQSFIASIQKISFFDGFEGGFNFR 1257
Query: 550 TTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKK 609
T +PNGL+ + D F+I + +G + ++D+ IK++++ K+
Sbjct: 1258 TLQPNGLLFYYASGS--------------DVFSISLDNGTV--IMDVKG--IKVQSVDKQ 1299
Query: 610 VNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDL---DDELYLGGLPENKAGLV 666
NDG + V + V+ R P + +I + + Y GG P
Sbjct: 1300 YNDGLSHFVISSVSPTRYELIVDKSRVGSKNPTKGKIEQTQASEKKFYFGGSP------- 1352
Query: 667 FPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSC-------------- 712
+ + GCI + + +D+ + T V S
Sbjct: 1353 ------ISAQYANFTGCISNAYFTRVDRDVEVEDFQRYTEKVHTSLYECPIESSPLFLLH 1406
Query: 713 --SKETAKPCLSNPCKNNGMCRDG--WNRYVCDCSGTG-------YLGRSCEREATVLSY 761
K +KP S K G +D W+ +L S Y
Sbjct: 1407 KKGKNLSKPKASQN-KKGGKSKDAPSWDPVALKLPERNTPRNSHCHLSNSPRAIEHAYQY 1465
Query: 762 DGSMFMKIQLPVVMHTEAE-----DVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRV 816
G+ + + H + + S+R R++ ++G++ + ++ D + L L GR+
Sbjct: 1466 GGTANSRQEFE---HLKGDFGAKSQFSIRLRTRSSHGMIFYVSDQEENDFMTLFLAHGRL 1522
Query: 817 KLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMA 876
N+ ++ S + ND WH V +R S +L +D + + +
Sbjct: 1523 VYMFNVGHKKLKIRSQE---------KYNDGLWHDVIFIRERSSGRLVIDGLRVLEESLP 1573
Query: 877 GDHTRLEFHN-IETGIITERRYLSSVPSN----FIGHLQSLTFNGMAYIDLCKNGDIDYC 931
+ I G + + + +V N F G L +L NG + + + C
Sbjct: 1574 PTEATWKIKGPIYLGGVAPGKAVKNVQINSIYSFSGCLSNLQLNGASITSASQTFSVTPC 1633
Query: 932 ELNARFGFRNIIADPVTFKTKSSYVAL-ATLQAYTSMHLFFQFKTTSLDGLILYNSGDGN 990
F + F T+ YV L + + F+ + S G +++
Sbjct: 1634 -------FEGPMETGTYFSTEGGYVVLDESFNIGLKFEIAFEVRPRSSSGTLVHGHSVNG 1686
Query: 991 DFIVVELVKGYLHYVFDLGNGANLIKGS--SNKPLNDNQWHNVMISRDTSNLHTVKIDTK 1048
+++ V + G + + + NG S + L D +WH + + RD SN+ + +D++
Sbjct: 1687 EYLNVHMKNGQV--IVKVNNGIRDFSTSVTPKQSLCDGRWHRITVIRD-SNVVQLDVDSE 1743
Query: 1049 ITTQI-TAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLIS 1107
+ + + +D + +++GGV + P+L +K F GC+ ++G P S
Sbjct: 1744 VNHVVGPLNPKPIDHREPVFVGGVPESLL--TPRLAPSKP-FTGCIRHFVIDGH-PVSFS 1799
Query: 1108 DALFCNGQI 1116
A +G +
Sbjct: 1800 KAALVSGAV 1808
Score = 56.2 bits (134), Expect = 2e-07
Identities = 86/370 (23%), Positives = 141/370 (38%), Gaps = 46/370 (12%)
Query: 362 DYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIG-HAMV 420
+Y+ LA+KN + V NLG+ E ++ + VK+ R +G H V
Sbjct: 886 EYMGLAIKNDNLVYVYNLGTKDVEIPLDSKPVSSWPAYFSIVKIER-------VGKHGKV 938
Query: 421 NKLHCSVTISVDGILTTTGYTQEDYTMLG---SDDFFYVGGSPSTADLPGSPVSNNFMGC 477
S++ + + G D ++L D FYVGG PS LP S F+GC
Sbjct: 939 FLTVPSLSSTAEEKFIKKGEFSGDDSLLDLDPEDTVFYVGGVPSNFKLPTSLNLPGFVGC 998
Query: 478 LKEVVYKNNDVRLELSRLAKQGDPKMKI---HGVVAFKCENVAT--LDPITFETPESFIS 532
L+ N+ + L + DP + +AF A+ D +
Sbjct: 999 LELATLNNDVISLYNFKHIYNMDPSTSVPCARDKLAFTQSRAASYFFDGSGYAVVRDITR 1058
Query: 533 LPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYL 592
K+ + + RT NGLIL FF +EM +G+L++
Sbjct: 1059 RGKFG--QVTRFDIEVRTPADNGLILLMVNGSM--------------FFRLEMRNGYLHV 1102
Query: 593 LLDMG--SGTIKIKALLKK--VNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILD 648
D G G + ++ LKK +ND +++ + I V R + E +
Sbjct: 1103 FYDFGFSGGPVHLEDTLKKAQINDAKYHEISIIYHNDKKMILVVDRRHVKSMDNEKMKIP 1162
Query: 649 LDDELYLGGLPENKAGLVFPTEVWTA--LLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTA 706
D +Y+GG P + + A L+ + GC++ Q KD + E T
Sbjct: 1163 FTD-IYIGGAPPE----ILQSRALRAHLPLDINFRGCMKG--FQFQKKDF-NLLEQTETL 1214
Query: 707 GVKPSCSKET 716
GV C +++
Sbjct: 1215 GVGYGCPEDS 1224
Score = 50.1 bits (118), Expect = 2e-05
Identities = 35/144 (24%), Positives = 68/144 (47%), Gaps = 7/144 (4%)
Query: 51 ESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVN 110
+S+ S +L+TRS+ G++ Y D+ DF+ L L GRL F++ + + + N
Sbjct: 1485 KSQFSIRLRTRSSHGMIFYVSDQEENDFMTLFLAH-GRLVYMFNV-GHKKLKIRSQEKYN 1542
Query: 111 DGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLT 170
DG WH V R+ + L ID + + + +++GG+ P A +
Sbjct: 1543 DGLWHDVIFIRERSSGRLVIDGLRVLEESLPPTEATWKIKGPIYLGGVAP--GKAVKNVQ 1600
Query: 171 LASVREREPFKGWIRDVRVNSSQV 194
+ S+ F G + ++++N + +
Sbjct: 1601 INSIYS---FSGCLSNLQLNGASI 1621
Score = 47.8 bits (112), Expect = 8e-05
Identities = 145/764 (18%), Positives = 275/764 (35%), Gaps = 143/764 (18%)
Query: 577 KVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYH--VDFQRDGRSGTISVNTL 634
K ++ + + + +L + ++G+ ++I K V+ Y V +R G+ G + +
Sbjct: 884 KKEYMGLAIKNDNLVYVYNLGTKDVEIPLDSKPVSSWPAYFSIVKIERVGKHGKVFLTVP 943
Query: 635 RTPYTAP----------GESEILDLDDE---LYLGGLPENKAGLVFPTEVWTALLNYGYV 681
TA G+ +LDLD E Y+GG+P N ++ T+L G+V
Sbjct: 944 SLSSTAEEKFIKKGEFSGDDSLLDLDPEDTVFYVGGVPSN-------FKLPTSLNLPGFV 996
Query: 682 GCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCD 741
GC+ + + D+ + + + PS S A+ L+ + Y D
Sbjct: 997 GCLE---LATLNNDVISLYNFKHIYNMDPSTSVPCARDKLA-------FTQSRAASYFFD 1046
Query: 742 CSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSR 801
G+GY + R+ T G + D+ +R + +LM S
Sbjct: 1047 --GSGY---AVVRDITRRGKFGQV------------TRFDIEVRTPADNGLILLMVNGSM 1089
Query: 802 DSADTLRLELDAGRVKLTVNLDCIRINCNSSKGP---ETLFAGYNLNDNEWHTVRVV-RR 857
RLE+ G + + + S GP E +ND ++H + ++
Sbjct: 1090 ----FFRLEMRNGYLHVFYDF-------GFSGGPVHLEDTLKKAQINDAKYHEISIIYHN 1138
Query: 858 GKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETG-----IITERRYLSSVPS--NFIGHLQ 910
K + L VD + + M + ++ F +I G I+ R + +P NF G ++
Sbjct: 1139 DKKMILVVDRRHVKS--MDNEKMKIPFTDIYIGGAPPEILQSRALRAHLPLDINFRGCMK 1196
Query: 911 SLTFNGMAYIDLCKNGDIDYCELNARFGFR------NIIADPVTFKTKSSYVALATLQAY 964
F + D + E G ++I+ F +S ++ + +
Sbjct: 1197 GFQF---------QKKDFNLLEQTETLGVGYGCPEDSLISRRAYFNGQSFIASIQKISFF 1247
Query: 965 TSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLN 1024
F F+T +GL+ Y + G+D + L G + + D+ + S +K N
Sbjct: 1248 DGFEGGFNFRTLQPNGLLFYYAS-GSDVFSISLDNGTV--IMDV---KGIKVQSVDKQYN 1301
Query: 1025 DNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLPKLVH 1084
D H V+ S + + +++ G++N K+ Y +
Sbjct: 1302 DGLSHFVISSVSPTRYELIVDKSRV------GSKNPTKGKIEQTQASEKKFYFGGSPISA 1355
Query: 1085 AKEGFQGCLAS-----VDLNGRLPD----------------LISDALFCNGQIERGCEGP 1123
F GC+++ VD + + D + S LF + + P
Sbjct: 1356 QYANFTGCISNAYFTRVDRDVEVEDFQRYTEKVHTSLYECPIESSPLFLLHKKGKNLSKP 1415
Query: 1124 STTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQI---TYKWP 1180
+ + ++ WD + P N P ++ + Y++
Sbjct: 1416 KASQNKKGGKSKDA--PSWDPVALKL-------PERNTPRNSHCHLSNSPRAIEHAYQYG 1466
Query: 1181 PNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGL---------GDYLELHIHQGKIGVKF 1231
+ L F + ++ +R SS G+ D++ L + G++ F
Sbjct: 1467 GTANSRQEFEHLKGDFGAKSQFSIRLRTRSSHGMIFYVSDQEENDFMTLFLAHGRLVYMF 1526
Query: 1232 NVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIE 1275
NVG + I S NDG +H V F R + L +D V+E
Sbjct: 1527 NVGHKKLKIR-SQEKYNDGLWHDVIFIRERSSGRLVIDGLRVLE 1569
Score = 47.4 bits (111), Expect = 1e-04
Identities = 71/390 (18%), Positives = 140/390 (35%), Gaps = 74/390 (18%)
Query: 337 SSDEITLSFKTLQRNGLMLHTG--KSADYVNLALKNGAVSLVINLGSGAFEALVEPVNGK 394
+ + ++ +T +G++ + + D++ L L +G + + N+G + + K
Sbjct: 1484 AKSQFSIRLRTRSSHGMIFYVSDQEENDFMTLFLAHGRLVYMFNVGHKKLKIRSQE---K 1540
Query: 395 FNDNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTISVDGILT---TTGYTQEDYTMLGSD 451
+ND WHDV R S + +DG+ + T+ + + G
Sbjct: 1541 YNDGLWHDVIFIRE---------------RSSGRLVIDGLRVLEESLPPTEATWKIKGP- 1584
Query: 452 DFFYVGGSPSTADLPGSPVSN-------NFMGCLKEVVYKNNDVRLELSRLAKQGDPKMK 504
Y+GG PG V N +F GCL + + +
Sbjct: 1585 --IYLGGVA-----PGKAVKNVQINSIYSFSGCLSNLQLNGASITSASQTFS-------- 1629
Query: 505 IHGVVAFKCENVATLDPITFETPESFISLPK-WNAKKTGSISFDFRTTEPNGLILFSHGK 563
C F T ++ L + +N I+F+ R +G ++ H
Sbjct: 1630 -----VTPCFEGPMETGTYFSTEGGYVVLDESFNIGLKFEIAFEVRPRSSSGTLVHGHS- 1683
Query: 564 PRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKK-VNDGEWYHVDFQR 622
+ ++ + M +G + + ++ G K+ + DG W+ + R
Sbjct: 1684 ------------VNGEYLNVHMKNGQVIVKVNNGIRDFSTSVTPKQSLCDGRWHRITVIR 1731
Query: 623 DGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVG 682
D + V++ P + +D + +++GG+PE+ L+ P + + G
Sbjct: 1732 DSNVVQLDVDSEVNHVVGPLNPKPIDHREPVFVGGVPES---LLTP----RLAPSKPFTG 1784
Query: 683 CIRDLFIDGQSKDIRQMAEVQSTAGVKPSC 712
CIR IDG + A V + SC
Sbjct: 1785 CIRHFVIDGHPVSFSKAALVSGAVSIN-SC 1813
Score = 35.8 bits (81), Expect = 0.33
Identities = 37/142 (26%), Positives = 61/142 (42%), Gaps = 21/142 (14%)
Query: 35 GAEGQWTRFPKWNACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFS 94
G GQ TRF +++T + GL+L + LE+ R G L + +
Sbjct: 1060 GKFGQVTRF-----------DIEVRTPADNGLILLMVNGSMFFRLEM---RNGYLHVFYD 1105
Query: 95 I-FCAEPATL---LADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVF 150
F P L L +ND +H + I + N I V+ + V+ + F
Sbjct: 1106 FGFSGGPVHLEDTLKKAQINDAKYHEISII--YHNDKKMILVVDRRHVKSMDNEKMKIPF 1163
Query: 151 SGLFVGGLPPE-LRAAALKLTL 171
+ +++GG PPE L++ AL+ L
Sbjct: 1164 TDIYIGGAPPEILQSRALRAHL 1185
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 59,579,138
Number of Sequences: 37866
Number of extensions: 2805717
Number of successful extensions: 10544
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 105
Number of HSP's successfully gapped in prelim test: 55
Number of HSP's that attempted gapping in prelim test: 7780
Number of HSP's gapped (non-prelim): 2015
length of query: 1547
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1432
effective length of database: 13,892,928
effective search space: 19894672896
effective search space used: 19894672896
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.