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Search of human proteins with 208431774
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|208431774 phosphatidylinositol-4-phosphate 5-kinase, type I,
alpha isoform 3 [Homo sapiens]
(522 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|208431774 phosphatidylinositol-4-phosphate 5-kinase, type I, ... 1049 0.0
gi|4505815 phosphatidylinositol-4-phosphate 5-kinase, type I, al... 1026 0.0
gi|208431778 phosphatidylinositol-4-phosphate 5-kinase, type I, ... 1024 0.0
gi|208431776 phosphatidylinositol-4-phosphate 5-kinase, type I, ... 904 0.0
gi|31317309 phosphatidylinositol-4-phosphate 5-kinase, type I, g... 620 e-177
gi|4505817 phosphatidylinositol-4-phosphate 5-kinase, type I, be... 548 e-156
gi|4505819 phosphatidylinositol-5-phosphate 4-kinase, type II, b... 154 1e-37
gi|6857820 phosphatidylinositol-5-phosphate 4-kinase, type II, a... 145 7e-35
gi|226371739 phosphatidylinositol-5-phosphate 4-kinase, type II,... 138 1e-32
gi|226371737 phosphatidylinositol-5-phosphate 4-kinase, type II,... 138 1e-32
gi|226371741 phosphatidylinositol-5-phosphate 4-kinase, type II,... 131 1e-30
gi|226371743 phosphatidylinositol-5-phosphate 4-kinase, type II,... 107 2e-23
gi|206725454 phosphatidylinositol-4-phosphate 5-kinase-like 1 is... 94 2e-19
gi|121583483 phosphatidylinositol-3-phosphate 5-kinase type III ... 53 8e-07
gi|27735085 phosphatidylinositol-4-phosphate 5-kinase-like 1 iso... 44 3e-04
gi|157168329 formin 1 [Homo sapiens] 34 0.37
gi|22027471 neuronal PAS domain protein 2 [Homo sapiens] 33 0.49
gi|197313638 N-methyl-D-aspartate receptor subunit 2A isoform 2 ... 33 0.63
gi|197313636 N-methyl-D-aspartate receptor subunit 2A isoform 1 ... 33 0.63
gi|4504125 N-methyl-D-aspartate receptor subunit 2A isoform 1 pr... 33 0.63
gi|222537754 hypothetical protein LOC375337 [Homo sapiens] 32 1.1
gi|33457336 chromosome 14 open reading frame 4 [Homo sapiens] 32 1.4
gi|112421134 hypothetical protein LOC23742 [Homo sapiens] 32 1.4
gi|156142176 hypothetical protein LOC29090 [Homo sapiens] 32 1.8
gi|221139926 NHS-like 1 [Homo sapiens] 31 2.4
gi|4504425 high-mobility group box 1 [Homo sapiens] 31 2.4
gi|58530863 melanoma antigen family A, 10 [Homo sapiens] 30 7.0
gi|10567820 melanoma antigen family A, 10 [Homo sapiens] 30 7.0
gi|5032193 TNF receptor-associated factor 1 [Homo sapiens] 29 9.2
gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo ... 29 9.2
>gi|208431774 phosphatidylinositol-4-phosphate 5-kinase, type I,
alpha isoform 3 [Homo sapiens]
Length = 522
Score = 1049 bits (2713), Expect = 0.0
Identities = 522/522 (100%), Positives = 522/522 (100%)
Query: 1 MASASSGPSSSVGFSSFDPAVPSCTLSSAASGIKRPMASEVPYASGMPIKKIGHRSVDSS 60
MASASSGPSSSVGFSSFDPAVPSCTLSSAASGIKRPMASEVPYASGMPIKKIGHRSVDSS
Sbjct: 1 MASASSGPSSSVGFSSFDPAVPSCTLSSAASGIKRPMASEVPYASGMPIKKIGHRSVDSS 60
Query: 61 GETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEGSNLTPAH 120
GETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEGSNLTPAH
Sbjct: 61 GETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEGSNLTPAH 120
Query: 121 HYNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEFI 180
HYNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEFI
Sbjct: 121 HYNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEFI 180
Query: 181 IKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSV 240
IKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSV
Sbjct: 181 IKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSV 240
Query: 241 KMHIKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDC 300
KMHIKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDC
Sbjct: 241 KMHIKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDC 300
Query: 301 LVLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALYSTAMESIQGEAR 360
LVLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALYSTAMESIQGEAR
Sbjct: 301 LVLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALYSTAMESIQGEAR 360
Query: 361 RGGTMETDDQFVKKLEHSWKALVHDGDTVSVHRPGFYAERFQRFMCNTVFKKIPLKPSPS 420
RGGTMETDDQFVKKLEHSWKALVHDGDTVSVHRPGFYAERFQRFMCNTVFKKIPLKPSPS
Sbjct: 361 RGGTMETDDQFVKKLEHSWKALVHDGDTVSVHRPGFYAERFQRFMCNTVFKKIPLKPSPS 420
Query: 421 KKFRSGSSFSRRAGSSGNSCITYQPSVSGEHKAQVTTKAEVEPGVHLGRPDVLPQTPPLE 480
KKFRSGSSFSRRAGSSGNSCITYQPSVSGEHKAQVTTKAEVEPGVHLGRPDVLPQTPPLE
Sbjct: 421 KKFRSGSSFSRRAGSSGNSCITYQPSVSGEHKAQVTTKAEVEPGVHLGRPDVLPQTPPLE 480
Query: 481 EISEGSPIPDPSFSPLVGETLQMLTTSTTLEKLEVAESEFTH 522
EISEGSPIPDPSFSPLVGETLQMLTTSTTLEKLEVAESEFTH
Sbjct: 481 EISEGSPIPDPSFSPLVGETLQMLTTSTTLEKLEVAESEFTH 522
>gi|4505815 phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
isoform 2 [Homo sapiens]
Length = 549
Score = 1026 bits (2654), Expect = 0.0
Identities = 520/550 (94%), Positives = 521/550 (94%), Gaps = 29/550 (5%)
Query: 1 MASASSGPSSSVGFSSFDPAVPSCTLSSAASGIKRPMASEVPYASGMPIKKIGHRSVDSS 60
MASASSGPSSSVGFSSFDPAVPSCTLSSA SGIKRPMASEVPYASGMPIKKIGHRSVDSS
Sbjct: 1 MASASSGPSSSVGFSSFDPAVPSCTLSSA-SGIKRPMASEVPYASGMPIKKIGHRSVDSS 59
Query: 61 GETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEGSNLTPAH 120
GETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEGSNLTPAH
Sbjct: 60 GETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEGSNLTPAH 119
Query: 121 HYNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEFI 180
HYNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEFI
Sbjct: 120 HYNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEFI 179
Query: 181 IKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSV 240
IKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSV
Sbjct: 180 IKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSV 239
Query: 241 KMHIKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDC 300
KMHIKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDC
Sbjct: 240 KMHIKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDC 299
Query: 301 LVLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALYSTAMESIQGEAR 360
LVLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALYSTAMESIQGEAR
Sbjct: 300 LVLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALYSTAMESIQGEAR 359
Query: 361 RGGTMETDD----------------------------QFVKKLEHSWKALVHDGDTVSVH 392
RGGTMETDD +FVKKLEHSWKALVHDGDTVSVH
Sbjct: 360 RGGTMETDDHMGGIPARNSKGERLLLYIGIIDILQSYRFVKKLEHSWKALVHDGDTVSVH 419
Query: 393 RPGFYAERFQRFMCNTVFKKIPLKPSPSKKFRSGSSFSRRAGSSGNSCITYQPSVSGEHK 452
RPGFYAERFQRFMCNTVFKKIPLKPSPSKKFRSGSSFSRRAGSSGNSCITYQPSVSGEHK
Sbjct: 420 RPGFYAERFQRFMCNTVFKKIPLKPSPSKKFRSGSSFSRRAGSSGNSCITYQPSVSGEHK 479
Query: 453 AQVTTKAEVEPGVHLGRPDVLPQTPPLEEISEGSPIPDPSFSPLVGETLQMLTTSTTLEK 512
AQVTTKAEVEPGVHLGRPDVLPQTPPLEEISEGSPIPDPSFSPLVGETLQMLTTSTTLEK
Sbjct: 480 AQVTTKAEVEPGVHLGRPDVLPQTPPLEEISEGSPIPDPSFSPLVGETLQMLTTSTTLEK 539
Query: 513 LEVAESEFTH 522
LEVAESEFTH
Sbjct: 540 LEVAESEFTH 549
>gi|208431778 phosphatidylinositol-4-phosphate 5-kinase, type I,
alpha isoform 1 [Homo sapiens]
Length = 562
Score = 1024 bits (2647), Expect = 0.0
Identities = 521/562 (92%), Positives = 522/562 (92%), Gaps = 40/562 (7%)
Query: 1 MASASSGPSSSVGFSSFDPAVPSCTLSSAASGIKRPMASEV------------PYASGMP 48
MASASSGPSSSVGFSSFDPAVPSCTLSSAASGIKRPMASEV PYASGMP
Sbjct: 1 MASASSGPSSSVGFSSFDPAVPSCTLSSAASGIKRPMASEVLEARQDSYISLVPYASGMP 60
Query: 49 IKKIGHRSVDSSGETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIF 108
IKKIGHRSVDSSGETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIF
Sbjct: 61 IKKIGHRSVDSSGETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIF 120
Query: 109 FPSEGSNLTPAHHYNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASG 168
FPSEGSNLTPAHHYNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASG
Sbjct: 121 FPSEGSNLTPAHHYNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASG 180
Query: 169 SLFYVSSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIR 228
SLFYVSSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIR
Sbjct: 181 SLFYVSSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIR 240
Query: 229 IVVMNNLLPRSVKMHIKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADM 288
IVVMNNLLPRSVKMHIKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADM
Sbjct: 241 IVVMNNLLPRSVKMHIKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADM 300
Query: 289 YNALCKTLQRDCLVLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALY 348
YNALCKTLQRDCLVLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALY
Sbjct: 301 YNALCKTLQRDCLVLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALY 360
Query: 349 STAMESIQGEARRGGTMETDD----------------------------QFVKKLEHSWK 380
STAMESIQGEARRGGTMETDD +FVKKLEHSWK
Sbjct: 361 STAMESIQGEARRGGTMETDDHMGGIPARNSKGERLLLYIGIIDILQSYRFVKKLEHSWK 420
Query: 381 ALVHDGDTVSVHRPGFYAERFQRFMCNTVFKKIPLKPSPSKKFRSGSSFSRRAGSSGNSC 440
ALVHDGDTVSVHRPGFYAERFQRFMCNTVFKKIPLKPSPSKKFRSGSSFSRRAGSSGNSC
Sbjct: 421 ALVHDGDTVSVHRPGFYAERFQRFMCNTVFKKIPLKPSPSKKFRSGSSFSRRAGSSGNSC 480
Query: 441 ITYQPSVSGEHKAQVTTKAEVEPGVHLGRPDVLPQTPPLEEISEGSPIPDPSFSPLVGET 500
ITYQPSVSGEHKAQVTTKAEVEPGVHLGRPDVLPQTPPLEEISEGSPIPDPSFSPLVGET
Sbjct: 481 ITYQPSVSGEHKAQVTTKAEVEPGVHLGRPDVLPQTPPLEEISEGSPIPDPSFSPLVGET 540
Query: 501 LQMLTTSTTLEKLEVAESEFTH 522
LQMLTTSTTLEKLEVAESEFTH
Sbjct: 541 LQMLTTSTTLEKLEVAESEFTH 562
>gi|208431776 phosphatidylinositol-4-phosphate 5-kinase, type I,
alpha isoform 4 [Homo sapiens]
Length = 500
Score = 904 bits (2337), Expect = 0.0
Identities = 470/550 (85%), Positives = 471/550 (85%), Gaps = 78/550 (14%)
Query: 1 MASASSGPSSSVGFSSFDPAVPSCTLSSAASGIKRPMASEVPYASGMPIKKIGHRSVDSS 60
MASASSGPSSSVGFSSFDPAVPSCTLSSA SGIKRPMASEVPYASGMPIKKIGHRSVDSS
Sbjct: 1 MASASSGPSSSVGFSSFDPAVPSCTLSSA-SGIKRPMASEVPYASGMPIKKIGHRSVDSS 59
Query: 61 GETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEGSNLTPAH 120
GETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEGSNLTPAH
Sbjct: 60 GETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEGSNLTPAH 119
Query: 121 HYNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEFI 180
HYNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEFI
Sbjct: 120 HYNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEFI 179
Query: 181 IKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSV 240
IKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSV
Sbjct: 180 IKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSV 239
Query: 241 KMHIKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDC 300
KMHIKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDC
Sbjct: 240 KMHIKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDC 299
Query: 301 LVLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALYSTAMESIQGEAR 360
LVLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALYSTAMESIQGEAR
Sbjct: 300 LVLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALYSTAMESIQGEAR 359
Query: 361 RGGTMETDD----------------------------QFVKKLEHSWKALVHDGDTVSVH 392
RGGTMETDD +FVKKLEHSWKALVHDGDTVSVH
Sbjct: 360 RGGTMETDDHMGGIPARNSKGERLLLYIGIIDILQSYRFVKKLEHSWKALVHDGDTVSVH 419
Query: 393 RPGFYAERFQRFMCNTVFKKIPLKPSPSKKFRSGSSFSRRAGSSGNSCITYQPSVSGEHK 452
RPGFYAERFQRFMCNTVFKKIP
Sbjct: 420 RPGFYAERFQRFMCNTVFKKIPC------------------------------------- 442
Query: 453 AQVTTKAEVEPGVHLGRPDVLPQTPPLEEISEGSPIPDPSFSPLVGETLQMLTTSTTLEK 512
VHLGRPDVLPQTPPLEEISEGSPIPDPSFSPLVGETLQMLTTSTTLEK
Sbjct: 443 ------------VHLGRPDVLPQTPPLEEISEGSPIPDPSFSPLVGETLQMLTTSTTLEK 490
Query: 513 LEVAESEFTH 522
LEVAESEFTH
Sbjct: 491 LEVAESEFTH 500
>gi|31317309 phosphatidylinositol-4-phosphate 5-kinase, type I,
gamma [Homo sapiens]
Length = 668
Score = 620 bits (1598), Expect = e-177
Identities = 331/508 (65%), Positives = 380/508 (74%), Gaps = 41/508 (8%)
Query: 20 AVPS----CTLSSAASGI--KRPMASEVPYASGMPI----KKIGHRSVDSSGETTYKKTT 69
AVPS S AA+G+ K+ +EV + P KK+GHR VD+SGETTYKKTT
Sbjct: 16 AVPSEAAWAAESGAAAGLAQKKAAPTEVLSMTAQPGPGHGKKLGHRGVDASGETTYKKTT 75
Query: 70 SSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEGSNLTPAHHYNDFRFKT 129
SS LKGAIQLGI +TVG LS+KPERDVLMQDFYVVESIFFPSEGSNLTPAHH+ DFRFKT
Sbjct: 76 SSTLKGAIQLGIGYTVGHLSSKPERDVLMQDFYVVESIFFPSEGSNLTPAHHFQDFRFKT 135
Query: 130 YAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEFIIKTVQHKEA 189
YAPVAFRYFRELFGIRPDDYLYSLC+EPLIEL + GASGSLFYV+SDDEFIIKTV HKEA
Sbjct: 136 YAPVAFRYFRELFGIRPDDYLYSLCNEPLIELSNPGASGSLFYVTSDDEFIIKTVMHKEA 195
Query: 190 EFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSVKMHIKYDLK 249
EFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQ+GGKNIR+VVMNN+LPR VKMH+K+DLK
Sbjct: 196 EFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGGKNIRVVVMNNILPRVVKMHLKFDLK 255
Query: 250 GSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDCLVLQSFKIM 309
GSTYKRRAS+KE+EK PT+KDLDF+QD+P+GL LDAD ++AL KTLQRDCLVL+SFKIM
Sbjct: 256 GSTYKRRASKKEKEKSFPTYKDLDFMQDMPEGLLLDADTFSALVKTLQRDCLVLESFKIM 315
Query: 310 DYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALYSTAMESIQGEARRGGTMETDD 369
DYSLL+ +HNID +RE + Q + D +RP QKALYSTAMESIQG A RG +E+DD
Sbjct: 316 DYSLLLGVHNIDQHERERQAQGAQSTSDEKRPVGQKALYSTAMESIQGGAARGEAIESDD 375
Query: 370 ----------------------------QFVKKLEHSWKALVHDGDTVSVHRPGFYAERF 401
+F+KKLEH+WKALVHDGDTVSVHRP FYAERF
Sbjct: 376 TMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKALVHDGDTVSVHRPSFYAERF 435
Query: 402 QRFMCNTVFKK-IPLKPSPSKKFRSGSSFS-RRAGSSGNSCITYQPSVSGEHKAQVTTKA 459
+FM NTVF+K LK SPSKK R G+ + + G + + PS E + +
Sbjct: 436 FKFMSNTVFRKNSSLKSSPSKKGRGGALLAVKPLGPTAAFSASQIPSEREEAQYDLRGAR 495
Query: 460 EVEPGVHLGRPDVLPQTPP-LEEISEGS 486
GRPD+LP TPP EE + S
Sbjct: 496 SYPTLEDEGRPDLLPCTPPSFEEATTAS 523
>gi|4505817 phosphatidylinositol-4-phosphate 5-kinase, type I, beta
isoform 2 [Homo sapiens]
Length = 540
Score = 548 bits (1412), Expect = e-156
Identities = 293/460 (63%), Positives = 338/460 (73%), Gaps = 46/460 (10%)
Query: 62 ETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEGSNLTPAHH 121
E TYKKT SSA+KGAIQLGI +TVG+L++KPERDVLMQDFYVVES+F PSEGSNLTPAHH
Sbjct: 18 EKTYKKTASSAIKGAIQLGIGYTVGNLTSKPERDVLMQDFYVVESVFLPSEGSNLTPAHH 77
Query: 122 YNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEFII 181
Y DFRFKTYAP+AFRYFRELFGI+PDDYLYS+CSEPLIEL + GASGSLF+V+SDDEFII
Sbjct: 78 YPDFRFKTYAPLAFRYFRELFGIKPDDYLYSICSEPLIELSNPGASGSLFFVTSDDEFII 137
Query: 182 KTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSVK 241
KTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYC+Q+GG NIRIVVMNN+LPRS++
Sbjct: 138 KTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCMQSGGINIRIVVMNNVLPRSMR 197
Query: 242 MHIKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDCL 301
MH YDLKGSTYKRRAS+KEREK PTFKDLDFLQD+ +GL+ D + YNAL KTLQRDC
Sbjct: 198 MHFTYDLKGSTYKRRASRKEREKSNPTFKDLDFLQDMHEGLYFDTETYNALMKTLQRDCR 257
Query: 302 VLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALYSTAMESIQGEARR 361
VL+SFKIMDYSLL+ IH +DH+ +E Q D +R QK LYSTAMESIQG +
Sbjct: 258 VLESFKIMDYSLLLGIHFLDHSLKEKEEETPQNVPDAKRTGMQKVLYSTAMESIQGPGKS 317
Query: 362 GGTMETDD------------------------------QFVKKLEHSWKALVHDGDTVSV 391
G + T++ + +KKLEHSWKALV+DGDTVSV
Sbjct: 318 GDGIITENPDTMGGIPAKSHRGEKLLLFMGIIDILQSYRLMKKLEHSWKALVYDGDTVSV 377
Query: 392 HRPGFYAERFQRFMCNTVFKKI-PLKPSPSKKFRSGSSFSRRAGSSGNSCITYQPSVSGE 450
HRP FYA+RF +FM + VFKKI LK SPSKK R S + +A S S+S E
Sbjct: 378 HRPSFYADRFLKFMNSRVFKKIQALKASPSKK-RCNSIAALKATSQ-----EIVSSISQE 431
Query: 451 HK---------AQVTTKAEVEPGVHLGRPDVLPQTPPLEE 481
K Q + + E RPD++P TP L E
Sbjct: 432 WKDEKRDLLTEGQSFSSLDEEALGSRHRPDLVPSTPSLFE 471
>gi|4505819 phosphatidylinositol-5-phosphate 4-kinase, type II, beta
[Homo sapiens]
Length = 416
Score = 154 bits (390), Expect = 1e-37
Identities = 118/393 (30%), Positives = 173/393 (44%), Gaps = 73/393 (18%)
Query: 70 SSALKGAIQLGITHTVGSLSTKPERDVLMQDFYV------VESIFFPSEGSNLTPAHHYN 123
S + + G+ HT+ LS P +LM D + V++ F E NL +
Sbjct: 39 SEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKE--NLP-----S 91
Query: 124 DFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEFIIKT 183
F+FK Y P+ FR RE FGI DY S+ I S G G+ F + D F+IKT
Sbjct: 92 RFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKT 151
Query: 184 VQHKEAEFLQKLLPGYYMNLNQ-NPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSVKM 242
V ++ + +L Y+ + + + TLLP+F G+Y + G +VV N+ + +
Sbjct: 152 VSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTV 211
Query: 243 HIKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDCLV 302
H KYDLKGST R AS KE+ K LPTFKD DFL + L + + + L+RD
Sbjct: 212 HRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNE-GQKLHVGEESKKNFLEKLKRDVEF 270
Query: 303 LQSFKIMDYSLLMSIHNIDHAQREPLSSETQ----------------------------- 333
L KIMDYSLL+ IH++D A++E + E +
Sbjct: 271 LAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNL 330
Query: 334 ------------------YSVDTRRPAPQKALYSTAMESIQGEARRGGTMETDDQFVKKL 375
Y++ + +P+K +Y A+ I T KK
Sbjct: 331 LSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDIL----------TPYDTKKKA 380
Query: 376 EHSWKALVHD-GDTVSVHRPGFYAERFQRFMCN 407
H+ K + H G +S P Y++RF FM N
Sbjct: 381 AHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSN 413
>gi|6857820 phosphatidylinositol-5-phosphate 4-kinase, type II,
alpha [Homo sapiens]
Length = 406
Score = 145 bits (367), Expect = 7e-35
Identities = 89/269 (33%), Positives = 141/269 (52%), Gaps = 15/269 (5%)
Query: 70 SSALKGAIQLGITHTVGSLSTKPERDVLMQDFYV------VESIFFPSEGSNLTPAHHYN 123
S L + G+ H++ LS +LM D + V++ F E P+H
Sbjct: 34 SDPLLSVLMWGVNHSINELSHVQIPVMLMPDDFKAYSKIKVDNHLFNKENM---PSH--- 87
Query: 124 DFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEFIIKT 183
F+FK Y P+ FR RE FGI D+ SL + S SG+ F+ S D +IIKT
Sbjct: 88 -FKFKEYCPMVFRNLRERFGIDDQDFQNSLTRSAPLPNDSQARSGARFHTSYDKRYIIKT 146
Query: 184 VQHKEAEFLQKLLPGYYMNLNQ-NPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSVKM 242
+ ++ + +L Y+ + + + TLLP+F G+Y + G I ++V N+ + +
Sbjct: 147 ITSEDVAEMHNILKKYHQYIVECHGITLLPQFLGMYRLNVDGVEIYVIVTRNVFSHRLSV 206
Query: 243 HIKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDCLV 302
+ KYDLKGST R AS KE+ K LPT KD DF+ + +++D + + L++D
Sbjct: 207 YRKYDLKGSTVAREASDKEKAKELPTLKDNDFINE-GQKIYIDDNNKKVFLEKLKKDVEF 265
Query: 303 LQSFKIMDYSLLMSIHNIDHAQREPLSSE 331
L K+MDYSLL+ IH+++ A++E + E
Sbjct: 266 LAQLKLMDYSLLVGIHDVERAEQEEVECE 294
>gi|226371739 phosphatidylinositol-5-phosphate 4-kinase, type II,
gamma isoform a [Homo sapiens]
Length = 421
Score = 138 bits (347), Expect = 1e-32
Identities = 117/381 (30%), Positives = 166/381 (43%), Gaps = 55/381 (14%)
Query: 73 LKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEG----SNLTPAHHYNDFRFK 128
L G G+ H++ LS P +L+ D + S + NL P+H F+FK
Sbjct: 47 LVGVFLWGVAHSINELSQVPPPVMLLPDDFKASSKIKVNNHLFHRENL-PSH----FKFK 101
Query: 129 TYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEFIIKTVQHKE 188
Y P FR R+ FGI DYL SL P E S G+ G F +S D +IK V ++
Sbjct: 102 EYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSE--SEGSDGR-FLISYDRTLVIKEVSSED 158
Query: 189 AEFLQKLLPGYYMNLNQ-NPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSVKMHIKYD 247
+ L Y+ + + + TLLP+F G+Y V ++ ++VM N+ + +H KYD
Sbjct: 159 IADMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYD 218
Query: 248 LKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDCLVLQSFK 307
LKGS R AS KE+ K LPT KD+DFL +++ + + L+RD L K
Sbjct: 219 LKGSLVSREASDKEKVKELPTLKDMDFLNK-NQKVYIGEEEKKIFLEKLKRDVEFLVQLK 277
Query: 308 IMDYSLLMSIHNI-------DHAQREPLSSETQYSVDTRRPAPQKALYSTAMESIQG--- 357
IMDYSLL+ IH+I + A SE P Y T+ E I G
Sbjct: 278 IMDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIH 337
Query: 358 ----------------------------EARRGGTMETDDQF--VKKLEHSWKALVHD-G 386
E G ++ Q+ KK H+ K + H G
Sbjct: 338 SHRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKKKAAHAAKTVKHGAG 397
Query: 387 DTVSVHRPGFYAERFQRFMCN 407
+S P YA+RF F+ N
Sbjct: 398 AEISTVHPEQYAKRFLDFITN 418
>gi|226371737 phosphatidylinositol-5-phosphate 4-kinase, type II,
gamma isoform a [Homo sapiens]
Length = 421
Score = 138 bits (347), Expect = 1e-32
Identities = 117/381 (30%), Positives = 166/381 (43%), Gaps = 55/381 (14%)
Query: 73 LKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEG----SNLTPAHHYNDFRFK 128
L G G+ H++ LS P +L+ D + S + NL P+H F+FK
Sbjct: 47 LVGVFLWGVAHSINELSQVPPPVMLLPDDFKASSKIKVNNHLFHRENL-PSH----FKFK 101
Query: 129 TYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEFIIKTVQHKE 188
Y P FR R+ FGI DYL SL P E S G+ G F +S D +IK V ++
Sbjct: 102 EYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSE--SEGSDGR-FLISYDRTLVIKEVSSED 158
Query: 189 AEFLQKLLPGYYMNLNQ-NPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSVKMHIKYD 247
+ L Y+ + + + TLLP+F G+Y V ++ ++VM N+ + +H KYD
Sbjct: 159 IADMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYD 218
Query: 248 LKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDCLVLQSFK 307
LKGS R AS KE+ K LPT KD+DFL +++ + + L+RD L K
Sbjct: 219 LKGSLVSREASDKEKVKELPTLKDMDFLNK-NQKVYIGEEEKKIFLEKLKRDVEFLVQLK 277
Query: 308 IMDYSLLMSIHNI-------DHAQREPLSSETQYSVDTRRPAPQKALYSTAMESIQG--- 357
IMDYSLL+ IH+I + A SE P Y T+ E I G
Sbjct: 278 IMDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIH 337
Query: 358 ----------------------------EARRGGTMETDDQF--VKKLEHSWKALVHD-G 386
E G ++ Q+ KK H+ K + H G
Sbjct: 338 SHRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKKKAAHAAKTVKHGAG 397
Query: 387 DTVSVHRPGFYAERFQRFMCN 407
+S P YA+RF F+ N
Sbjct: 398 AEISTVHPEQYAKRFLDFITN 418
>gi|226371741 phosphatidylinositol-5-phosphate 4-kinase, type II,
gamma isoform b [Homo sapiens]
Length = 403
Score = 131 bits (330), Expect = 1e-30
Identities = 111/377 (29%), Positives = 158/377 (41%), Gaps = 65/377 (17%)
Query: 73 LKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEGSNLTPAHHYNDFRFKTYAP 132
L G G+ H++ LS P +L+ D + S + K Y P
Sbjct: 47 LVGVFLWGVAHSINELSQVPPPVMLLPDDFKASS-------------------KIKEYCP 87
Query: 133 VAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEFIIKTVQHKEAEFL 192
FR R+ FGI DYL SL P E S G+ G F +S D +IK V ++ +
Sbjct: 88 QVFRNLRDRFGIDDQDYLVSLTRNPPSE--SEGSDGR-FLISYDRTLVIKEVSSEDIADM 144
Query: 193 QKLLPGYYMNLNQ-NPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSVKMHIKYDLKGS 251
L Y+ + + + TLLP+F G+Y V ++ ++VM N+ + +H KYDLKGS
Sbjct: 145 HSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGS 204
Query: 252 TYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDCLVLQSFKIMDY 311
R AS KE+ K LPT KD+DFL +++ + + L+RD L KIMDY
Sbjct: 205 LVSREASDKEKVKELPTLKDMDFLNK-NQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDY 263
Query: 312 SLLMSIHNI-------DHAQREPLSSETQYSVDTRRPAPQKALYSTAMESIQG------- 357
SLL+ IH+I + A SE P Y T+ E I G
Sbjct: 264 SLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRP 323
Query: 358 ------------------------EARRGGTMETDDQF--VKKLEHSWKALVHD-GDTVS 390
E G ++ Q+ KK H+ K + H G +S
Sbjct: 324 LGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKKKAAHAAKTVKHGAGAEIS 383
Query: 391 VHRPGFYAERFQRFMCN 407
P YA+RF F+ N
Sbjct: 384 TVHPEQYAKRFLDFITN 400
>gi|226371743 phosphatidylinositol-5-phosphate 4-kinase, type II,
gamma isoform c [Homo sapiens]
Length = 373
Score = 107 bits (268), Expect = 2e-23
Identities = 105/380 (27%), Positives = 146/380 (38%), Gaps = 101/380 (26%)
Query: 73 LKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEG----SNLTPAHHYNDFRFK 128
L G G+ H++ LS P +L+ D + S + NL P+H F+FK
Sbjct: 47 LVGVFLWGVAHSINELSQVPPPVMLLPDDFKASSKIKVNNHLFHRENL-PSH----FKFK 101
Query: 129 TYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEFIIKTVQHKE 188
Y P FR R+ FGI DYLY I+K
Sbjct: 102 EYCPQVFRNLRDRFGIDDQDYLY----------------------------IVKC----- 128
Query: 189 AEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSVKMHIKYDL 248
+ TLLP+F G+Y V ++ ++VM N+ + +H KYDL
Sbjct: 129 -----------------HGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDL 171
Query: 249 KGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDCLVLQSFKI 308
KGS R AS KE+ K LPT KD+DFL +++ + + L+RD L KI
Sbjct: 172 KGSLVSREASDKEKVKELPTLKDMDFLNK-NQKVYIGEEEKKIFLEKLKRDVEFLVQLKI 230
Query: 309 MDYSLLMSIHNI-------DHAQREPLSSETQYSVDTRRPAPQKALYSTAMESIQG---- 357
MDYSLL+ IH+I + A SE P Y T+ E I G
Sbjct: 231 MDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHS 290
Query: 358 ---------------------------EARRGGTMETDDQF--VKKLEHSWKALVHD-GD 387
E G ++ Q+ KK H+ K + H G
Sbjct: 291 HRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKKKAAHAAKTVKHGAGA 350
Query: 388 TVSVHRPGFYAERFQRFMCN 407
+S P YA+RF F+ N
Sbjct: 351 EISTVHPEQYAKRFLDFITN 370
>gi|206725454 phosphatidylinositol-4-phosphate 5-kinase-like 1
isoform 1 [Homo sapiens]
Length = 394
Score = 94.4 bits (233), Expect = 2e-19
Identities = 83/304 (27%), Positives = 134/304 (44%), Gaps = 26/304 (8%)
Query: 116 LTPAHHYNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLC-SEPLIELCSSGASGSLFYVS 174
LT H F T A AF + R G+ +DY +L P ++ S+ S + F++S
Sbjct: 88 LTQVHE--GFELGTLAGPAFAWLRRSLGLAEEDYQAALGPGGPYLQFLSTSKSKASFFLS 145
Query: 175 SDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAG-GKNIRIVVMN 233
D F +KT +E + L LP Y +L ++P +LL + G++ ++ GK +VM
Sbjct: 146 HDQRFFLKTQGRREVQALLAHLPRYVQHLQRHPHSLLARLLGVHSLRVDRGKKTYFIVMQ 205
Query: 234 NLLPRSVKMHIKYDLKGSTYKRRASQKEREKPLP-TFKDLDFLQDIPDGLFLDADMYNA- 291
++ + ++ +YD+KG R PL KDL+F G ++ +
Sbjct: 206 SVFYPAGRISERYDIKGCEVSRWVDPAPEGSPLVLVLKDLNF-----QGKTINLGPQRSW 260
Query: 292 LCKTLQRDCLVLQSFKIMDYSLLMSIHNIDHAQREPLSS---ETQYSVD-TRRPAPQKAL 347
+ ++ D L+ ++DYSLL++ + +R P SS T SV + P +A
Sbjct: 261 FLRQMELDTTFLRELNVLDYSLLIAFQRLHEDERGPGSSLIFRTARSVQGAQSPEESRAQ 320
Query: 348 -------YSTAMESIQGEARRGGTMETDDQFV----KKLEHSWKALVHDGDTVSVHRPGF 396
A+ + G +R D V K+LEH WK L + G T S P
Sbjct: 321 NRRLLPDAPNALHILDGPEQRYFLGVVDLATVYGLRKRLEHLWKTLRYPGRTFSTVSPAR 380
Query: 397 YAER 400
YA R
Sbjct: 381 YARR 384
>gi|121583483 phosphatidylinositol-3-phosphate 5-kinase type III
isoform 2 [Homo sapiens]
Length = 2098
Score = 52.8 bits (125), Expect = 8e-07
Identities = 55/204 (26%), Positives = 86/204 (42%), Gaps = 15/204 (7%)
Query: 125 FRFKTYAPVAFRYFRE-LFGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEFIIKT 183
F + Y F RE + +D++ SL + G SG+ FY + DD FI+K
Sbjct: 1820 FYCRLYYAGEFHKMREVILDSSEEDFIRSLSHSSPWQ-ARGGKSGAAFYATEDDRFILKQ 1878
Query: 184 VQHKEAEFLQKLLPGYYMNL----NQNPRTLLPKFYGLYCV------QAGGKNIRIVVMN 233
+ E + P Y+ + Q T L K G+Y + K + ++VM
Sbjct: 1879 MPRLEVQSFLDFAPHYFNYITNAVQQKRPTALAKILGVYRIGYKNSQNNTEKKLDLLVME 1938
Query: 234 NLLPRSVKMHIKYDLKGSTYKRRA-SQKEREKPLPTFKDLDFLQDIPDG-LFLDADMYNA 291
NL KM +DLKGS R + +E D + L+ + D L++ +
Sbjct: 1939 NLF-YGRKMAQVFDLKGSLRNRNVKTDTGKESCDVVLLDENLLKMVRDNPLYIRSHSKAV 1997
Query: 292 LCKTLQRDCLVLQSFKIMDYSLLM 315
L ++ D L S I+DYSLL+
Sbjct: 1998 LRTSIHSDSHFLSSHLIIDYSLLV 2021
>gi|27735085 phosphatidylinositol-4-phosphate 5-kinase-like 1
isoform 2 [Homo sapiens]
Length = 191
Score = 44.3 bits (103), Expect = 3e-04
Identities = 45/173 (26%), Positives = 69/173 (39%), Gaps = 22/173 (12%)
Query: 245 KYDLKGSTYKRRASQKEREKPLP-TFKDLDFLQDIPDGLFLDADMYNA-LCKTLQRDCLV 302
+YD+KG R PL KDL+F G ++ + + ++ D
Sbjct: 14 RYDIKGCEVSRWVDPAPEGSPLVLVLKDLNF-----QGKTINLGPQRSWFLRQMELDTTF 68
Query: 303 LQSFKIMDYSLLMSIHNIDHAQREPLSS---ETQYSVDTRRPAPQKALYS--------TA 351
L+ ++DYSLL++ + +R P SS T SV + + + A
Sbjct: 69 LRELNVLDYSLLIAFQRLHEDERGPGSSLIFRTARSVQGAQSPEESRAQNRRLLPDAPNA 128
Query: 352 MESIQGEARRGGTMETDDQFV----KKLEHSWKALVHDGDTVSVHRPGFYAER 400
+ + G +R D V K+LEH WK L + G T S P YA R
Sbjct: 129 LHILDGPEQRYFLGVVDLATVYGLRKRLEHLWKTLRYPGRTFSTVSPARYARR 181
>gi|157168329 formin 1 [Homo sapiens]
Length = 1196
Score = 33.9 bits (76), Expect = 0.37
Identities = 38/151 (25%), Positives = 54/151 (35%), Gaps = 25/151 (16%)
Query: 366 ETDDQFVKKLEHSWKALVHDGDTVSVHRPGFYAERFQRFMCNTVFKKIPLKP--SPSKKF 423
ET + +LEH W+ + V + + R +C ++ LKP S SK
Sbjct: 541 ETIENLKHELEHRWRGGCEERKDVCISTDDDCPPKTFRNVCVQTDRETFLKPCESESKTT 600
Query: 424 RSGSSFSRRAGSSGNSCITYQPSVSGEHK------------AQVTTKAEVEPGVHLGRPD 471
RS ++ S S Q S +HK A KA P + P
Sbjct: 601 RSNQLVPKKLNISSLS----QLSPPNDHKDIHAALQPMEGMASNQQKALPPPPASIPPPP 656
Query: 472 VLPQ-------TPPLEEISEGSPIPDPSFSP 495
LP PP+ +S G P+P P P
Sbjct: 657 PLPSGLGSLSPAPPMPPVSAGPPLPPPPPPP 687
>gi|22027471 neuronal PAS domain protein 2 [Homo sapiens]
Length = 824
Score = 33.5 bits (75), Expect = 0.49
Identities = 27/112 (24%), Positives = 48/112 (42%), Gaps = 7/112 (6%)
Query: 410 FKKIPLKPSPSKKFRSGSSFSRRAGSSGNSCITYQPSVSGEHKAQVTTKAEVEPGVHLGR 469
F + + S S S+ SR + S ++ ++ S + A+ +T A L R
Sbjct: 392 FNTLDVGASGLNTSHSPSASSRSSHKSSHTAMSEPTSTPTKLMAEASTPA-------LPR 444
Query: 470 PDVLPQTPPLEEISEGSPIPDPSFSPLVGETLQMLTTSTTLEKLEVAESEFT 521
LPQ P+ +S+ + +P P SP + Q L T L+ ++F+
Sbjct: 445 SATLPQELPVPGLSQAATMPAPLPSPSSCDLTQQLLPQTVLQSTPAPMAQFS 496
>gi|197313638 N-methyl-D-aspartate receptor subunit 2A isoform 2
precursor [Homo sapiens]
Length = 1281
Score = 33.1 bits (74), Expect = 0.63
Identities = 38/182 (20%), Positives = 71/182 (39%), Gaps = 17/182 (9%)
Query: 318 HNIDHAQREPLSSETQYSVDTRRPAPQKALYSTAMESI-QGEARRGGTMETDDQFVKKLE 376
H + + P + E S +++ + + L+ +++SI Q + + D+ +
Sbjct: 984 HPLTLNESNPNTVEVAVSTESKANSRPRQLWKKSVDSIRQDSLSQNPVSQRDEATAENRT 1043
Query: 377 HSWKALVHDGDTVSVHRPGFYAERFQRFMCNTVFKKIPLKPSPSKKFRSGSSFSRRAGSS 436
HS K+ + + ++ +E R C+ +P SK ++ +F R S
Sbjct: 1044 HSLKSPRYLPEEMA---HSDISETSNRATCHR-------EPDNSKNHKTKDNFKRSVASK 1093
Query: 437 -GNSCI----TYQPSVSGEHKAQV-TTKAEVEPGVHLGRPDVLPQTPPLEEISEGSPIPD 490
C TY + S + ++ T E EPG HL P + E + P D
Sbjct: 1094 YPKDCSEVERTYLKTKSSSPRDKIYTIDGEKEPGFHLDPPQFVENVTLPENVDFPDPYQD 1153
Query: 491 PS 492
PS
Sbjct: 1154 PS 1155
>gi|197313636 N-methyl-D-aspartate receptor subunit 2A isoform 1
precursor [Homo sapiens]
Length = 1464
Score = 33.1 bits (74), Expect = 0.63
Identities = 38/182 (20%), Positives = 71/182 (39%), Gaps = 17/182 (9%)
Query: 318 HNIDHAQREPLSSETQYSVDTRRPAPQKALYSTAMESI-QGEARRGGTMETDDQFVKKLE 376
H + + P + E S +++ + + L+ +++SI Q + + D+ +
Sbjct: 984 HPLTLNESNPNTVEVAVSTESKANSRPRQLWKKSVDSIRQDSLSQNPVSQRDEATAENRT 1043
Query: 377 HSWKALVHDGDTVSVHRPGFYAERFQRFMCNTVFKKIPLKPSPSKKFRSGSSFSRRAGSS 436
HS K+ + + ++ +E R C+ +P SK ++ +F R S
Sbjct: 1044 HSLKSPRYLPEEMA---HSDISETSNRATCHR-------EPDNSKNHKTKDNFKRSVASK 1093
Query: 437 -GNSCI----TYQPSVSGEHKAQV-TTKAEVEPGVHLGRPDVLPQTPPLEEISEGSPIPD 490
C TY + S + ++ T E EPG HL P + E + P D
Sbjct: 1094 YPKDCSEVERTYLKTKSSSPRDKIYTIDGEKEPGFHLDPPQFVENVTLPENVDFPDPYQD 1153
Query: 491 PS 492
PS
Sbjct: 1154 PS 1155
>gi|4504125 N-methyl-D-aspartate receptor subunit 2A isoform 1
precursor [Homo sapiens]
Length = 1464
Score = 33.1 bits (74), Expect = 0.63
Identities = 38/182 (20%), Positives = 71/182 (39%), Gaps = 17/182 (9%)
Query: 318 HNIDHAQREPLSSETQYSVDTRRPAPQKALYSTAMESI-QGEARRGGTMETDDQFVKKLE 376
H + + P + E S +++ + + L+ +++SI Q + + D+ +
Sbjct: 984 HPLTLNESNPNTVEVAVSTESKANSRPRQLWKKSVDSIRQDSLSQNPVSQRDEATAENRT 1043
Query: 377 HSWKALVHDGDTVSVHRPGFYAERFQRFMCNTVFKKIPLKPSPSKKFRSGSSFSRRAGSS 436
HS K+ + + ++ +E R C+ +P SK ++ +F R S
Sbjct: 1044 HSLKSPRYLPEEMA---HSDISETSNRATCHR-------EPDNSKNHKTKDNFKRSVASK 1093
Query: 437 -GNSCI----TYQPSVSGEHKAQV-TTKAEVEPGVHLGRPDVLPQTPPLEEISEGSPIPD 490
C TY + S + ++ T E EPG HL P + E + P D
Sbjct: 1094 YPKDCSEVERTYLKTKSSSPRDKIYTIDGEKEPGFHLDPPQFVENVTLPENVDFPDPYQD 1153
Query: 491 PS 492
PS
Sbjct: 1154 PS 1155
>gi|222537754 hypothetical protein LOC375337 [Homo sapiens]
Length = 1692
Score = 32.3 bits (72), Expect = 1.1
Identities = 11/46 (23%), Positives = 29/46 (63%)
Query: 272 LDFLQDIPDGLFLDADMYNALCKTLQRDCLVLQSFKIMDYSLLMSI 317
+++ + P G++ D + N L +L + CL+ + F+I++ S+++ +
Sbjct: 1150 MEYYRKFPPGVYFDLQVLNDLLNSLLKHCLLKEVFQIVNLSIMVKM 1195
>gi|33457336 chromosome 14 open reading frame 4 [Homo sapiens]
Length = 796
Score = 32.0 bits (71), Expect = 1.4
Identities = 26/83 (31%), Positives = 34/83 (40%), Gaps = 5/83 (6%)
Query: 416 KPSPSKKFRSGSSFSRRAGSSGNSCITYQPSVSGEHKAQVTTKAEVEPGVHLGRPD---V 472
+ SP+ + S SRR G +T P+ G Q+T + P L P V
Sbjct: 213 RQSPNSSSAAASVASRRGTHGG--LVTGLPNPGGGGGPQLTVPPNLLPQTLLNGPASAAV 270
Query: 473 LPQTPPLEEISEGSPIPDPSFSP 495
LP PP S G P P P +P
Sbjct: 271 LPPPPPHALGSRGPPTPAPPGAP 293
>gi|112421134 hypothetical protein LOC23742 [Homo sapiens]
Length = 1156
Score = 32.0 bits (71), Expect = 1.4
Identities = 34/151 (22%), Positives = 57/151 (37%), Gaps = 14/151 (9%)
Query: 328 LSSETQYSVDTRRPAPQKALYSTAMESIQGEARRGGTMETDDQFVKKLEHSWKALVHDGD 387
L S + +V R+P P L T + + +G R + D ++ + + + G+
Sbjct: 127 LPSPREPAVKARKPIPATLLEETEVWAQEGPRRV--KKDEDPVQIEGEDDEKRTPLSSGE 184
Query: 388 TVSVHRPGFYAERFQRFMCNTVFKKIPLKPSPSKKFRSGSSFSRRAGSSGNSCITYQPSV 447
S R F C+ PL+ + KF S + S +SC+
Sbjct: 185 ASSTSRSQGTQGDVASFRCSPG----PLEGNVYHKFSENSMSEKAQASPASSCL------ 234
Query: 448 SGEHKAQVTTKAEVEPGVHLGRPDVLPQTPP 478
E A +T ++ HLG+PD PP
Sbjct: 235 --EGPAMPSTHSQAGCARHLGKPDPDATAPP 263
>gi|156142176 hypothetical protein LOC29090 [Homo sapiens]
Length = 248
Score = 31.6 bits (70), Expect = 1.8
Identities = 25/90 (27%), Positives = 42/90 (46%), Gaps = 10/90 (11%)
Query: 332 TQYSVDTRRPAPQKALYSTAMESIQGEARRGGTMETDDQFVKKLEHSWKALVHDGDTVSV 391
TQ ++ T+ P+P+KA + + ++RGGT Q VK+ + L+ +S+
Sbjct: 61 TQKTIWTQGPSPRKAKEDGSKQVSVHRSQRGGTAVPTSQKVKEAGRDFTYLIVVLFGISI 120
Query: 392 HRPGFYAERFQRFMCNTVFKKIPLKPSPSK 421
FY T+FK++ SPSK
Sbjct: 121 TGGLFY----------TIFKELFSSSSPSK 140
>gi|221139926 NHS-like 1 [Homo sapiens]
Length = 1606
Score = 31.2 bits (69), Expect = 2.4
Identities = 27/100 (27%), Positives = 37/100 (37%), Gaps = 14/100 (14%)
Query: 416 KPSPSKKFRSGSSFSRRAGSSGNSCITYQPSVSGEHKAQVTTKAEVEPGVH--------- 466
KP P R S S + SS ++ ++ S G + A P
Sbjct: 880 KPKPKVPERKSSLISSVSISSSSTSLSSSTSTEGSGTMKKLDPAVGSPPAPPPPPVPSPP 939
Query: 467 ----LGRPDVLPQTPPLEEISEGSPIP-DPSFSPLVGETL 501
R LP PP+ + S+GSP+P P F P E L
Sbjct: 940 FPCPADRSPFLPPPPPVTDCSQGSPLPHSPVFPPPPPEAL 979
>gi|4504425 high-mobility group box 1 [Homo sapiens]
Length = 215
Score = 31.2 bits (69), Expect = 2.4
Identities = 28/124 (22%), Positives = 51/124 (41%), Gaps = 20/124 (16%)
Query: 337 DTRRPAPQKALYSTAMESIQGEARRG--GTMETDDQFVKKLEHSWKALVHDGDTVSVHRP 394
D ++P + + Y+ +++ + E ++ +F KK WK T+S
Sbjct: 5 DPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWK-------TMSAKEK 57
Query: 395 GFYAE-------RFQRFMCNTVFKKIPLKPSPSKKFRSGSSFSRRAGSSGNSCITYQPSV 447
G + + R++R M IP K KKF+ ++ R + C Y+P +
Sbjct: 58 GKFEDMAKADKARYEREMKTY----IPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKI 113
Query: 448 SGEH 451
GEH
Sbjct: 114 KGEH 117
>gi|58530863 melanoma antigen family A, 10 [Homo sapiens]
Length = 369
Score = 29.6 bits (65), Expect = 7.0
Identities = 29/92 (31%), Positives = 40/92 (43%), Gaps = 6/92 (6%)
Query: 427 SSFSRRAGSSGNSCITYQPSVSGEHKAQVTTKAEVEPG-VHLGRPDVLPQTPPLEEISEG 485
SSF + SS +SC PS E A T + + P V+ PL++ EG
Sbjct: 50 SSFPSSSSSSSSSCYPLIPSTPEEVSADDETPNPPQSAQIACSSPSVVASL-PLDQSDEG 108
Query: 486 SPIPDPSFSPLVGETLQMLTTSTTLEKLEVAE 517
S SP TLQ+L S +L + E+ E
Sbjct: 109 SS-SQKEESP---STLQVLPDSESLPRSEIDE 136
>gi|10567820 melanoma antigen family A, 10 [Homo sapiens]
Length = 369
Score = 29.6 bits (65), Expect = 7.0
Identities = 29/92 (31%), Positives = 40/92 (43%), Gaps = 6/92 (6%)
Query: 427 SSFSRRAGSSGNSCITYQPSVSGEHKAQVTTKAEVEPG-VHLGRPDVLPQTPPLEEISEG 485
SSF + SS +SC PS E A T + + P V+ PL++ EG
Sbjct: 50 SSFPSSSSSSSSSCYPLIPSTPEEVSADDETPNPPQSAQIACSSPSVVASL-PLDQSDEG 108
Query: 486 SPIPDPSFSPLVGETLQMLTTSTTLEKLEVAE 517
S SP TLQ+L S +L + E+ E
Sbjct: 109 SS-SQKEESP---STLQVLPDSESLPRSEIDE 136
>gi|5032193 TNF receptor-associated factor 1 [Homo sapiens]
Length = 416
Score = 29.3 bits (64), Expect = 9.2
Identities = 36/162 (22%), Positives = 63/162 (38%), Gaps = 16/162 (9%)
Query: 247 DLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDCLVLQSF 306
DL+ Y+ S+ + E L F L ++ L + ++ L K ++ L L +
Sbjct: 159 DLEVDCYRAPCSESQEELALQHFMKEKLLAELEGKLRVFENIVAVLNKEVEASHLALAT- 217
Query: 307 KIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALYSTAMESIQGEARRGGTME 366
SIH RE + S Q V+ ++ QK A+ ++ R
Sbjct: 218 ---------SIHQ-SQLDRERILSLEQRVVELQQTLAQK---DQALGKLEQSLRLMEEAS 264
Query: 367 TDDQFVKKLEHSWKALVHD--GDTVSVHRPGFYAERFQRFMC 406
D F+ K+ + + G TVS+ P FY ++ +C
Sbjct: 265 FDGTFLWKITNVTRRCHESACGRTVSLFSPAFYTAKYGYKLC 306
>gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo
sapiens]
Length = 666
Score = 29.3 bits (64), Expect = 9.2
Identities = 17/53 (32%), Positives = 33/53 (62%), Gaps = 2/53 (3%)
Query: 247 DLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMY-NALCKTLQR 298
DL+ + + S+ E +P P K LD++QD G+F +A +Y +++ ++L+R
Sbjct: 284 DLENEPWYKFFSELEFGRPPPK-KPLDYVQDHSSGVFNEASLYQSSIDRSLER 335
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.385
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,008,210
Number of Sequences: 37866
Number of extensions: 1016025
Number of successful extensions: 3080
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 16
Number of HSP's successfully gapped in prelim test: 16
Number of HSP's that attempted gapping in prelim test: 3028
Number of HSP's gapped (non-prelim): 45
length of query: 522
length of database: 18,247,518
effective HSP length: 107
effective length of query: 415
effective length of database: 14,195,856
effective search space: 5891280240
effective search space used: 5891280240
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.