Search of human proteins with 207113186

Search of human proteins with 207113186

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|207113186 MAP kinase-interacting serine/threonine kinase 1
isoform 3 [Homo sapiens]
         (424 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|207113186 MAP kinase-interacting serine/threonine kinase 1 is...   857   0.0  
gi|21361101 MAP kinase-interacting serine/threonine kinase 1 iso...   837   0.0  
gi|39752689 MAP kinase-interacting serine/threonine kinase 1 iso...   686   0.0  
gi|40018627 MAP kinase-interacting serine/threonine kinase 2 iso...   602   e-172
gi|40018631 MAP kinase-interacting serine/threonine kinase 2 iso...   550   e-157
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is...   189   3e-48
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is...   189   3e-48
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is...   189   3e-48
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is...   189   3e-48
gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4 is...   183   3e-46
gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4 iso...   183   3e-46
gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a...   182   4e-46
gi|4758700 mitogen-activated protein kinase-activated protein ki...   181   1e-45
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho...   180   2e-45
gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo...   178   7e-45
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]   172   4e-43
gi|4758128 doublecortin-like kinase 1 [Homo sapiens]                  172   5e-43
gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens]      172   7e-43
gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens]      172   7e-43
gi|21237768 MAP kinase-activated protein kinase 5 isoform 2 [Hom...   171   2e-42
gi|21237765 MAP kinase-activated protein kinase 5 isoform 1 [Hom...   171   2e-42
gi|32481209 mitogen-activated protein kinase-activated protein k...   170   3e-42
gi|10863901 mitogen-activated protein kinase-activated protein k...   170   3e-42
gi|27901803 protein serine kinase H1 [Homo sapiens]                   170   3e-42
gi|9966875 calcium/calmodulin-dependent protein kinase ID isofor...   169   3e-42
gi|23943850 calcium/calmodulin-dependent protein kinase ID isofo...   169   3e-42
gi|212549756 calcium/calmodulin-dependent protein kinase II delt...   168   7e-42
gi|26667183 calcium/calmodulin-dependent protein kinase II delta...   168   7e-42
gi|212549753 calcium/calmodulin-dependent protein kinase II delt...   168   7e-42
gi|26667186 calcium/calmodulin-dependent protein kinase II delta...   168   7e-42

>gi|207113186 MAP kinase-interacting serine/threonine kinase 1
           isoform 3 [Homo sapiens]
          Length = 424

 Score =  857 bits (2213), Expect = 0.0
 Identities = 424/424 (100%), Positives = 424/424 (100%)

Query: 1   MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY 60
           MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY
Sbjct: 1   MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY 60

Query: 61  AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF 120
           AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF
Sbjct: 61  AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF 120

Query: 121 YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAHRDLKPENILCES 180
           YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAHRDLKPENILCES
Sbjct: 121 YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAHRDLKPENILCES 180

Query: 181 PEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKR 240
           PEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKR
Sbjct: 181 PEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKR 240

Query: 241 CDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWA 300
           CDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWA
Sbjct: 241 CDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWA 300

Query: 301 HISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLF 360
           HISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLF
Sbjct: 301 HISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLF 360

Query: 361 AAEAIALNRQLSQHEENELAEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSP 420
           AAEAIALNRQLSQHEENELAEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSP
Sbjct: 361 AAEAIALNRQLSQHEENELAEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSP 420

Query: 421 PTAL 424
           PTAL
Sbjct: 421 PTAL 424


>gi|21361101 MAP kinase-interacting serine/threonine kinase 1
           isoform 1 [Homo sapiens]
          Length = 465

 Score =  837 bits (2161), Expect = 0.0
 Identities = 424/465 (91%), Positives = 424/465 (91%), Gaps = 41/465 (8%)

Query: 1   MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY 60
           MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY
Sbjct: 1   MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY 60

Query: 61  AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF 120
           AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF
Sbjct: 61  AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF 120

Query: 121 YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTK---------------- 164
           YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTK                
Sbjct: 121 YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPS 180

Query: 165 -------------------------GIAHRDLKPENILCESPEKVSPVKICDFDLGSGMK 199
                                    GIAHRDLKPENILCESPEKVSPVKICDFDLGSGMK
Sbjct: 181 GLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMK 240

Query: 200 LNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPP 259
           LNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPP
Sbjct: 241 LNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPP 300

Query: 260 FVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAK 319
           FVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAK
Sbjct: 301 FVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAK 360

Query: 320 QRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENEL 379
           QRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENEL
Sbjct: 361 QRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENEL 420

Query: 380 AEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL 424
           AEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL
Sbjct: 421 AEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL 465


>gi|39752689 MAP kinase-interacting serine/threonine kinase 1
           isoform 2 [Homo sapiens]
          Length = 347

 Score =  686 bits (1771), Expect = 0.0
 Identities = 336/341 (98%), Positives = 337/341 (98%)

Query: 1   MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY 60
           MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY
Sbjct: 1   MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY 60

Query: 61  AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF 120
           AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF
Sbjct: 61  AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF 120

Query: 121 YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAHRDLKPENILCES 180
           YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAHRDLKPENILCES
Sbjct: 121 YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAHRDLKPENILCES 180

Query: 181 PEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKR 240
           PEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKR
Sbjct: 181 PEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKR 240

Query: 241 CDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWA 300
           CDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWA
Sbjct: 241 CDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWA 300

Query: 301 HISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKG 341
           HISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQG+    G
Sbjct: 301 HISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGEQQHNG 341


>gi|40018627 MAP kinase-interacting serine/threonine kinase 2
           isoform 2 [Homo sapiens]
          Length = 465

 Score =  602 bits (1551), Expect = e-172
 Identities = 295/407 (72%), Positives = 343/407 (84%), Gaps = 10/407 (2%)

Query: 12  EMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAYAKVQGAVSLQN 71
           +M +S+P+ I D  +R KKK+RGRATDS  G+FED+Y+L  ++LGEGA+A+VQ  ++L  
Sbjct: 47  DMPASQPIDIPDAKKRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLIT 106

Query: 72  GKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGS 131
            +EYAVKIIEKQ GH RSRVFREVE LYQCQG++N+LELIEFFE++ RFYLVFEK++GGS
Sbjct: 107 SQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGS 166

Query: 132 ILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAHRDLKPENILCESPEKVSPVKICD 191
           IL+HI K++HFNE EAS VV+DVA+ALDFLH KGIAHRDLKPENILCE P +VSPVKICD
Sbjct: 167 ILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICD 226

Query: 192 FDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLY 251
           FDLGSG+KLN  C+PI+TPEL TPCGSAEYMAPEVVE F+++A+ YDKRCDLWSLGV+LY
Sbjct: 227 FDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILY 286

Query: 252 IMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLIS 311
           I+LSGYPPFVG CG+DCGWDRGE C  CQN LFESIQEGKYEFPDKDWAHIS  AKDLIS
Sbjct: 287 ILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLIS 346

Query: 312 KLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQL 371
           KLLVRDAKQRLSAAQVLQHPWVQG APE  LPTP VLQRNS   DLT FAAEAIA+NRQL
Sbjct: 347 KLLVRDAKQRLSAAQVLQHPWVQGCAPENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQL 406

Query: 372 SQHEENELAEEPEA--------LADGLCSMKLSPPCKSRLARRRALA 410
           +QH+E +LAEE  A         A   C ++LSPP +S+LA+RR  A
Sbjct: 407 AQHDE-DLAEEEAAGQGQPVLVRATSRC-LQLSPPSQSKLAQRRQRA 451


>gi|40018631 MAP kinase-interacting serine/threonine kinase 2
           isoform 1 [Homo sapiens]
          Length = 414

 Score =  550 bits (1418), Expect = e-157
 Identities = 259/339 (76%), Positives = 298/339 (87%)

Query: 12  EMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAYAKVQGAVSLQN 71
           +M +S+P+ I D  +R KKK+RGRATDS  G+FED+Y+L  ++LGEGA+A+VQ  ++L  
Sbjct: 47  DMPASQPIDIPDAKKRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLIT 106

Query: 72  GKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGS 131
            +EYAVKIIEKQ GH RSRVFREVE LYQCQG++N+LELIEFFE++ RFYLVFEK++GGS
Sbjct: 107 SQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGS 166

Query: 132 ILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAHRDLKPENILCESPEKVSPVKICD 191
           IL+HI K++HFNE EAS VV+DVA+ALDFLH KGIAHRDLKPENILCE P +VSPVKICD
Sbjct: 167 ILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICD 226

Query: 192 FDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLY 251
           FDLGSG+KLN  C+PI+TPEL TPCGSAEYMAPEVVE F+++A+ YDKRCDLWSLGV+LY
Sbjct: 227 FDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILY 286

Query: 252 IMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLIS 311
           I+LSGYPPFVG CG+DCGWDRGE C  CQN LFESIQEGKYEFPDKDWAHIS  AKDLIS
Sbjct: 287 ILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLIS 346

Query: 312 KLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLPTPQVLQR 350
           KLLVRDAKQRLSAAQVLQHPWVQG APE  LPTP VLQR
Sbjct: 347 KLLVRDAKQRLSAAQVLQHPWVQGCAPENTLPTPMVLQR 385


>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
           isoform b [Homo sapiens]
          Length = 744

 Score =  189 bits (481), Expect = 3e-48
 Identities = 129/365 (35%), Positives = 190/365 (52%), Gaps = 36/365 (9%)

Query: 23  DGDRRRKKKRRGRATDSLPGK---FEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKI 79
           DG  R  +         L GK   F D Y +  E +G G+Y++ +  V      EYAVK+
Sbjct: 399 DGKPRAPQAPLHSVVQQLHGKNLVFSDGY-VVKETIGVGSYSECKRCVHKATNMEYAVKV 457

Query: 80  IEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQ 139
           I+K    S+     E+E L +   + NI+ L + ++D    YLV E ++GG +L  I +Q
Sbjct: 458 IDK----SKRDPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQ 513

Query: 140 KHFNEREASRVVRDVAAALDFLHTKGIAHRDLKPENIL-CESPEKVSPVKICDFDLGSGM 198
           K F+EREAS V+  +   +++LH++G+ HRDLKP NIL  +       ++ICDF     +
Sbjct: 514 KFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQL 573

Query: 199 KLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYP 258
           +  N         L TPC +A ++APEV+     +   YD+ CD+WSLG++LY ML+GY 
Sbjct: 574 RAENGL-------LMTPCYTANFVAPEVL-----KRQGYDEGCDIWSLGILLYTMLAGYT 621

Query: 259 PFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDA 318
           PF     A+   D  E       ++   I  GK+     +W  +S  AKDL+SK+L  D 
Sbjct: 622 PF-----ANGPSDTPE-------EILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDP 669

Query: 319 KQRLSAAQVLQHPWV--QGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEE 376
            QRL+A QVLQHPWV  + + P+  L + Q LQ     M  T  A  +     QL   E 
Sbjct: 670 HQRLTAKQVLQHPWVTQKDKLPQSQL-SHQDLQLVKGAMAATYSALNSSKPTPQLKPIES 728

Query: 377 NELAE 381
           + LA+
Sbjct: 729 SILAQ 733



 Score =  102 bits (253), Expect = 9e-22
 Identities = 80/276 (28%), Positives = 134/276 (48%), Gaps = 38/276 (13%)

Query: 53  ELLGEGAYAKV---QGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILE 109
           ++LG+G++ KV   +      +G  YA+K+++K     R RV  ++E       N   + 
Sbjct: 75  KVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVV 134

Query: 110 LIEF-FEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAH 168
            + + F+ + + YL+ + L+GG +   + K+  F E +    + ++A  LD LH+ GI +
Sbjct: 135 KLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIY 194

Query: 169 RDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVE 228
           RDLKPENIL    ++   +K+ DF L S   +++        +  + CG+ EYMAPEVV 
Sbjct: 195 RDLKPENILL---DEEGHIKLTDFGL-SKEAIDHE------KKAYSFCGTVEYMAPEVV- 243

Query: 229 VFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQ 288
                   +    D WS GV+++ ML+G  PF G        DR E   +        I 
Sbjct: 244 ----NRQGHSHSADWWSYGVLMFEMLTGSLPFQGK-------DRKETMTL--------IL 284

Query: 289 EGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSA 324
           + K   P      +S+EA+ L+  L  R+   RL +
Sbjct: 285 KAKLGMPQ----FLSTEAQSLLRALFKRNPANRLGS 316


>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
           isoform a [Homo sapiens]
          Length = 735

 Score =  189 bits (481), Expect = 3e-48
 Identities = 129/365 (35%), Positives = 190/365 (52%), Gaps = 36/365 (9%)

Query: 23  DGDRRRKKKRRGRATDSLPGK---FEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKI 79
           DG  R  +         L GK   F D Y +  E +G G+Y++ +  V      EYAVK+
Sbjct: 390 DGKPRAPQAPLHSVVQQLHGKNLVFSDGY-VVKETIGVGSYSECKRCVHKATNMEYAVKV 448

Query: 80  IEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQ 139
           I+K    S+     E+E L +   + NI+ L + ++D    YLV E ++GG +L  I +Q
Sbjct: 449 IDK----SKRDPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQ 504

Query: 140 KHFNEREASRVVRDVAAALDFLHTKGIAHRDLKPENIL-CESPEKVSPVKICDFDLGSGM 198
           K F+EREAS V+  +   +++LH++G+ HRDLKP NIL  +       ++ICDF     +
Sbjct: 505 KFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQL 564

Query: 199 KLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYP 258
           +  N         L TPC +A ++APEV+     +   YD+ CD+WSLG++LY ML+GY 
Sbjct: 565 RAENGL-------LMTPCYTANFVAPEVL-----KRQGYDEGCDIWSLGILLYTMLAGYT 612

Query: 259 PFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDA 318
           PF     A+   D  E       ++   I  GK+     +W  +S  AKDL+SK+L  D 
Sbjct: 613 PF-----ANGPSDTPE-------EILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDP 660

Query: 319 KQRLSAAQVLQHPWV--QGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEE 376
            QRL+A QVLQHPWV  + + P+  L + Q LQ     M  T  A  +     QL   E 
Sbjct: 661 HQRLTAKQVLQHPWVTQKDKLPQSQL-SHQDLQLVKGAMAATYSALNSSKPTPQLKPIES 719

Query: 377 NELAE 381
           + LA+
Sbjct: 720 SILAQ 724



 Score =  102 bits (253), Expect = 9e-22
 Identities = 80/276 (28%), Positives = 134/276 (48%), Gaps = 38/276 (13%)

Query: 53  ELLGEGAYAKV---QGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILE 109
           ++LG+G++ KV   +      +G  YA+K+++K     R RV  ++E       N   + 
Sbjct: 66  KVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVV 125

Query: 110 LIEF-FEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAH 168
            + + F+ + + YL+ + L+GG +   + K+  F E +    + ++A  LD LH+ GI +
Sbjct: 126 KLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIY 185

Query: 169 RDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVE 228
           RDLKPENIL    ++   +K+ DF L S   +++        +  + CG+ EYMAPEVV 
Sbjct: 186 RDLKPENILL---DEEGHIKLTDFGL-SKEAIDHE------KKAYSFCGTVEYMAPEVV- 234

Query: 229 VFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQ 288
                   +    D WS GV+++ ML+G  PF G        DR E   +        I 
Sbjct: 235 ----NRQGHSHSADWWSYGVLMFEMLTGSLPFQGK-------DRKETMTL--------IL 275

Query: 289 EGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSA 324
           + K   P      +S+EA+ L+  L  R+   RL +
Sbjct: 276 KAKLGMPQ----FLSTEAQSLLRALFKRNPANRLGS 307


>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
           isoform b [Homo sapiens]
          Length = 741

 Score =  189 bits (481), Expect = 3e-48
 Identities = 130/368 (35%), Positives = 190/368 (51%), Gaps = 55/368 (14%)

Query: 44  FEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQG 103
           F D Y++  ++ G G+Y+  +  V      EYAVKII+K    S+     E+E L +   
Sbjct: 419 FTDGYEIKEDI-GVGSYSVCKRCVHKATDTEYAVKIIDK----SKRDPSEEIEILLRYGQ 473

Query: 104 NKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHT 163
           + NI+ L + ++D    YLV E ++GG +L  I +Q++F+EREAS V+  +   +D+LH+
Sbjct: 474 HPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHS 533

Query: 164 KGIAHRDLKPENILCESPEKVSP--VKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEY 221
           +G+ HRDLKP NIL    E  SP  +++CDF     ++  N         L TPC +A +
Sbjct: 534 QGVVHRDLKPSNILYRD-ESGSPESIRVCDFGFAKQLRAGNGL-------LMTPCYTANF 585

Query: 222 MAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQN 281
           +APEV+     +   YD  CD+WSLG++LY ML+G+ PF    G D   D  E       
Sbjct: 586 VAPEVL-----KRQGYDAACDIWSLGILLYTMLAGFTPFAN--GPD---DTPE------- 628

Query: 282 KLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKG 341
           ++   I  GKY     +W  IS  AKD++SK+L  D  QRL+A QVL+HPWV      + 
Sbjct: 629 EILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHPWV----VNRE 684

Query: 342 LPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEPEALADGLCSMKLSPPCKS 401
             +P  L R    +     AA   ALNR             P+A        +L P   S
Sbjct: 685 YLSPNQLSRQDVHLVKGAMAATYFALNR------------TPQA-------PRLEPVLSS 725

Query: 402 RLARRRAL 409
            LA+RR +
Sbjct: 726 NLAQRRGM 733



 Score =  108 bits (271), Expect = 7e-24
 Identities = 88/301 (29%), Positives = 144/301 (47%), Gaps = 48/301 (15%)

Query: 41  PGKFEDMYKLTSELLGEGAYAKV---QGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVET 97
           P +FE +     ++LG+G+Y KV   +       G+ YA+K+++K     R RV  ++E 
Sbjct: 64  PSQFELL-----KVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMER 118

Query: 98  LYQCQGNKNILELIEF-FEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAA 156
               + N   +  + + F+ + + YL+ + L+GG +   + K+  F E +    + ++A 
Sbjct: 119 DILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL 178

Query: 157 ALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPC 216
           ALD LH+ GI +RDLKPENIL    ++   +KI DF L      ++           + C
Sbjct: 179 ALDHLHSLGIIYRDLKPENILL---DEEGHIKITDFGLSKEAIDHDK-------RAYSFC 228

Query: 217 GSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVC 276
           G+ EYMAPEVV         + +  D WS GV+++ ML+G  PF G        DR E  
Sbjct: 229 GTIEYMAPEVV-----NRRGHTQSADWWSFGVLMFEMLTGSLPFQGK-------DRKETM 276

Query: 277 RVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAA-----QVLQHP 331
            +        I + K   P      +S EA+ L+  L  R+   RL A      ++ +HP
Sbjct: 277 AL--------ILKAKLGMPQ----FLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHP 324

Query: 332 W 332
           +
Sbjct: 325 F 325


>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
           isoform a [Homo sapiens]
          Length = 733

 Score =  189 bits (481), Expect = 3e-48
 Identities = 130/368 (35%), Positives = 190/368 (51%), Gaps = 55/368 (14%)

Query: 44  FEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQG 103
           F D Y++  ++ G G+Y+  +  V      EYAVKII+K    S+     E+E L +   
Sbjct: 411 FTDGYEIKEDI-GVGSYSVCKRCVHKATDTEYAVKIIDK----SKRDPSEEIEILLRYGQ 465

Query: 104 NKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHT 163
           + NI+ L + ++D    YLV E ++GG +L  I +Q++F+EREAS V+  +   +D+LH+
Sbjct: 466 HPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHS 525

Query: 164 KGIAHRDLKPENILCESPEKVSP--VKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEY 221
           +G+ HRDLKP NIL    E  SP  +++CDF     ++  N         L TPC +A +
Sbjct: 526 QGVVHRDLKPSNILYRD-ESGSPESIRVCDFGFAKQLRAGNGL-------LMTPCYTANF 577

Query: 222 MAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQN 281
           +APEV+     +   YD  CD+WSLG++LY ML+G+ PF    G D   D  E       
Sbjct: 578 VAPEVL-----KRQGYDAACDIWSLGILLYTMLAGFTPFAN--GPD---DTPE------- 620

Query: 282 KLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKG 341
           ++   I  GKY     +W  IS  AKD++SK+L  D  QRL+A QVL+HPWV      + 
Sbjct: 621 EILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHPWV----VNRE 676

Query: 342 LPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEPEALADGLCSMKLSPPCKS 401
             +P  L R    +     AA   ALNR             P+A        +L P   S
Sbjct: 677 YLSPNQLSRQDVHLVKGAMAATYFALNR------------TPQA-------PRLEPVLSS 717

Query: 402 RLARRRAL 409
            LA+RR +
Sbjct: 718 NLAQRRGM 725



 Score =  108 bits (271), Expect = 7e-24
 Identities = 88/301 (29%), Positives = 144/301 (47%), Gaps = 48/301 (15%)

Query: 41  PGKFEDMYKLTSELLGEGAYAKV---QGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVET 97
           P +FE +     ++LG+G+Y KV   +       G+ YA+K+++K     R RV  ++E 
Sbjct: 56  PSQFELL-----KVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMER 110

Query: 98  LYQCQGNKNILELIEF-FEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAA 156
               + N   +  + + F+ + + YL+ + L+GG +   + K+  F E +    + ++A 
Sbjct: 111 DILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL 170

Query: 157 ALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPC 216
           ALD LH+ GI +RDLKPENIL    ++   +KI DF L      ++           + C
Sbjct: 171 ALDHLHSLGIIYRDLKPENILL---DEEGHIKITDFGLSKEAIDHDK-------RAYSFC 220

Query: 217 GSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVC 276
           G+ EYMAPEVV         + +  D WS GV+++ ML+G  PF G        DR E  
Sbjct: 221 GTIEYMAPEVV-----NRRGHTQSADWWSFGVLMFEMLTGSLPFQGK-------DRKETM 268

Query: 277 RVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAA-----QVLQHP 331
            +        I + K   P      +S EA+ L+  L  R+   RL A      ++ +HP
Sbjct: 269 AL--------ILKAKLGMPQ----FLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHP 316

Query: 332 W 332
           +
Sbjct: 317 F 317


>gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4
           isoform b [Homo sapiens]
          Length = 766

 Score =  183 bits (464), Expect = 3e-46
 Identities = 115/323 (35%), Positives = 176/323 (54%), Gaps = 26/323 (8%)

Query: 50  LTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILE 109
           L    LG+G+++  +     Q+G+E+AVKI+ ++     +   REV  L  CQ + N++ 
Sbjct: 406 LREPALGQGSFSVCRRCRQRQSGQEFAVKILSRRL---EANTQREVAALRLCQSHPNVVN 462

Query: 110 LIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTK-GIAH 168
           L E   D    YLV E L+GG +L HI+K++HF+E EAS+++R + +A+ F+H + G+ H
Sbjct: 463 LHEVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVH 522

Query: 169 RDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVE 228
           RDLKPENIL       +PVKI DF   + ++  +   P     + TPC + +Y APE++ 
Sbjct: 523 RDLKPENILYADDTPGAPVKIIDFGF-ARLRPQSPGVP-----MQTPCFTLQYAAPELL- 575

Query: 229 VFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQ 288
                   YD+ CDLWSLGV+LY+MLSG  PF G  G        E+  +C+      I+
Sbjct: 576 ----AQQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEI--MCK------IR 623

Query: 289 EGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLP--TPQ 346
           EG++    + W  +S EAK+L+  LL  D  +RL    +    W+Q  +     P  TP 
Sbjct: 624 EGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGLRGSSWLQDGSARSSPPLRTPD 683

Query: 347 VLQRNSSTMDLTLFAAEAIALNR 369
           VL+ +   +   L  A  +A NR
Sbjct: 684 VLESSGPAVRSGL-NATFMAFNR 705



 Score =  114 bits (285), Expect = 2e-25
 Identities = 89/301 (29%), Positives = 142/301 (47%), Gaps = 52/301 (17%)

Query: 53  ELLGEGAYAKV---QGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILE 109
           ++LG GAY KV   + A     GK YA+K++ K A   R++      T       +++LE
Sbjct: 37  KVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRT------ERSVLE 90

Query: 110 LIE----------FFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALD 159
           L+            F+ D + +L+ + + GG +  H+ ++++F E E      ++  AL+
Sbjct: 91  LVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALE 150

Query: 160 FLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSA 219
            LH  GI +RDLK EN+L +S      + + DF L                   + CG+ 
Sbjct: 151 HLHKLGIIYRDLKLENVLLDSE---GHIVLTDFGLSKEFLTEEK------ERTFSFCGTI 201

Query: 220 EYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVC 279
           EYMAPE++       T + K  D WSLG++L+ +L+G  PF            GE  R  
Sbjct: 202 EYMAPEIIR----SKTGHGKAVDWWSLGILLFELLTGASPFT---------LEGE--RNT 246

Query: 280 QNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAA-----QVLQHPWVQ 334
           Q ++   I +    FP +    I   A+DL+ +LL +D K+RL A      +V  HP+ Q
Sbjct: 247 QAEVSRRILKCSPPFPPR----IGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQ 302

Query: 335 G 335
           G
Sbjct: 303 G 303


>gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4
           isoform a [Homo sapiens]
          Length = 772

 Score =  183 bits (464), Expect = 3e-46
 Identities = 115/323 (35%), Positives = 176/323 (54%), Gaps = 26/323 (8%)

Query: 50  LTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILE 109
           L    LG+G+++  +     Q+G+E+AVKI+ ++     +   REV  L  CQ + N++ 
Sbjct: 412 LREPALGQGSFSVCRRCRQRQSGQEFAVKILSRRL---EANTQREVAALRLCQSHPNVVN 468

Query: 110 LIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTK-GIAH 168
           L E   D    YLV E L+GG +L HI+K++HF+E EAS+++R + +A+ F+H + G+ H
Sbjct: 469 LHEVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVH 528

Query: 169 RDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVE 228
           RDLKPENIL       +PVKI DF   + ++  +   P     + TPC + +Y APE++ 
Sbjct: 529 RDLKPENILYADDTPGAPVKIIDFGF-ARLRPQSPGVP-----MQTPCFTLQYAAPELL- 581

Query: 229 VFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQ 288
                   YD+ CDLWSLGV+LY+MLSG  PF G  G        E+  +C+      I+
Sbjct: 582 ----AQQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEI--MCK------IR 629

Query: 289 EGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLP--TPQ 346
           EG++    + W  +S EAK+L+  LL  D  +RL    +    W+Q  +     P  TP 
Sbjct: 630 EGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGLRGSSWLQDGSARSSPPLRTPD 689

Query: 347 VLQRNSSTMDLTLFAAEAIALNR 369
           VL+ +   +   L  A  +A NR
Sbjct: 690 VLESSGPAVRSGL-NATFMAFNR 711



 Score =  114 bits (285), Expect = 2e-25
 Identities = 89/301 (29%), Positives = 142/301 (47%), Gaps = 52/301 (17%)

Query: 53  ELLGEGAYAKV---QGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILE 109
           ++LG GAY KV   + A     GK YA+K++ K A   R++      T       +++LE
Sbjct: 37  KVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRT------ERSVLE 90

Query: 110 LIE----------FFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALD 159
           L+            F+ D + +L+ + + GG +  H+ ++++F E E      ++  AL+
Sbjct: 91  LVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALE 150

Query: 160 FLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSA 219
            LH  GI +RDLK EN+L +S      + + DF L                   + CG+ 
Sbjct: 151 HLHKLGIIYRDLKLENVLLDSE---GHIVLTDFGLSKEFLTEEK------ERTFSFCGTI 201

Query: 220 EYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVC 279
           EYMAPE++       T + K  D WSLG++L+ +L+G  PF            GE  R  
Sbjct: 202 EYMAPEIIR----SKTGHGKAVDWWSLGILLFELLTGASPFT---------LEGE--RNT 246

Query: 280 QNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAA-----QVLQHPWVQ 334
           Q ++   I +    FP +    I   A+DL+ +LL +D K+RL A      +V  HP+ Q
Sbjct: 247 QAEVSRRILKCSPPFPPR----IGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQ 302

Query: 335 G 335
           G
Sbjct: 303 G 303


>gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a
           [Homo sapiens]
          Length = 802

 Score =  182 bits (463), Expect = 4e-46
 Identities = 108/301 (35%), Positives = 159/301 (52%), Gaps = 25/301 (8%)

Query: 50  LTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILE 109
           L  + LGEG+++  +  V  ++ + +AVKII K+     +   +E+  L  C+G+ NI++
Sbjct: 427 LKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRM---EANTQKEITALKLCEGHPNIVK 483

Query: 110 LIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAHR 169
           L E F D    +LV E L GG +   I+K+KHF+E EAS ++R + +A+  +H  G+ HR
Sbjct: 484 LHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHR 543

Query: 170 DLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEV 229
           DLKPEN+L         +KI DF             P     L TPC +  Y APE++  
Sbjct: 544 DLKPENLLFTDENDNLEIKIIDFGFA-------RLKPPDNQPLKTPCFTLHYAAPELL-- 594

Query: 230 FTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQE 289
                  YD+ CDLWSLGV+LY MLSG  PF  H       DR   C     ++ + I++
Sbjct: 595 ---NQNGYDESCDLWSLGVILYTMLSGQVPFQSH-------DRSLTC-TSAVEIMKKIKK 643

Query: 290 GKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQ--GQAPEKGLPTPQV 347
           G + F  + W ++S EAKDLI  LL  D  +RL  + +  + W+Q   Q     L TP +
Sbjct: 644 GDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLMTPDI 703

Query: 348 L 348
           L
Sbjct: 704 L 704



 Score =  115 bits (289), Expect = 6e-26
 Identities = 87/294 (29%), Positives = 147/294 (50%), Gaps = 39/294 (13%)

Query: 53  ELLGEGAYAKV---QGAVSLQNGKEYAVKIIEK----QAGHSRSRVFREVETLYQCQGNK 105
           ++LG GAY KV   +       GK YA+K+++K    Q   +      E + L   + + 
Sbjct: 53  KVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSP 112

Query: 106 NILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKG 165
            ++ L   F+ +T+ +L+ + + GG +  H+ +++ F E E    V ++  AL+ LH  G
Sbjct: 113 FLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLG 172

Query: 166 IAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPE 225
           I +RD+K ENIL +S      V + DF L      +       T    + CG+ EYMAP+
Sbjct: 173 IIYRDIKLENILLDSN---GHVVLTDFGLSKEFVADE------TERAYSFCGTIEYMAPD 223

Query: 226 VVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFE 285
           +V       + +DK  D WSLGV++Y +L+G  PF            GE  +  Q ++  
Sbjct: 224 IVR---GGDSGHDKAVDWWSLGVLMYELLTGASPFTVD---------GE--KNSQAEISR 269

Query: 286 SIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRL-----SAAQVLQHPWVQ 334
            I + +  +P +    +S+ AKDLI +LL++D K+RL      A ++ +H + Q
Sbjct: 270 RILKSEPPYPQE----MSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQ 319


>gi|4758700 mitogen-activated protein kinase-activated protein
           kinase 3 [Homo sapiens]
          Length = 382

 Score =  181 bits (458), Expect = 1e-45
 Identities = 114/355 (32%), Positives = 183/355 (51%), Gaps = 43/355 (12%)

Query: 12  EMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFE--DMYKLTSELLGEGAYAKVQGAVSL 69
           E G   P P+A G         GR     P K+   D Y+L+ ++LG G   KV      
Sbjct: 8   EQGGPVPPPVAPGGPGLGGAPGGRRE---PKKYAVTDDYQLSKQVLGLGVNGKVLECFHR 64

Query: 70  QNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTR----FYLVFE 125
           + G++ A+K++     +   +  +EV+  +Q  G  +I+ +++ +E+         ++ E
Sbjct: 65  RTGQKCALKLL-----YDSPKARQEVDHHWQASGGPHIVCILDVYENMHHGKRCLLIIME 119

Query: 126 KLQGGSILAHIQKQ--KHFNEREASRVVRDVAAALDFLHTKGIAHRDLKPENILCESPEK 183
            ++GG + + IQ++  + F EREA+ ++RD+  A+ FLH+  IAHRD+KPEN+L  S EK
Sbjct: 120 CMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEK 179

Query: 184 VSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDL 243
            + +K+ DF               T   L TPC +  Y+APEV+         YDK CD+
Sbjct: 180 DAVLKLTDFGFAK---------ETTQNALQTPCYTPYYVAPEVL-----GPEKYDKSCDM 225

Query: 244 WSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHIS 303
           WSLGV++YI+L G+PPF  + G           +     +   I+ G+Y FP+ +W+ +S
Sbjct: 226 WSLGVIMYILLCGFPPFYSNTG-----------QAISPGMKRRIRLGQYGFPNPEWSEVS 274

Query: 304 SEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQ--APEKGLPTPQVLQRNSSTMD 356
            +AK LI  LL  D  +RL+  Q + HPW+      P+  L T +VLQ +    D
Sbjct: 275 EDAKQLIRLLLKTDPTERLTITQFMNHPWINQSMVVPQTPLHTARVLQEDKDHWD 329


>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
           sapiens]
          Length = 740

 Score =  180 bits (457), Expect = 2e-45
 Identities = 117/331 (35%), Positives = 177/331 (53%), Gaps = 33/331 (9%)

Query: 43  KFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQ 102
           +F D Y++  ++ G G+Y+  +  +      E+AVKII+K    S+     E+E L +  
Sbjct: 417 QFTDGYEVKEDI-GVGSYSVCKRCIHKATNMEFAVKIIDK----SKRDPTEEIEILLRYG 471

Query: 103 GNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLH 162
            + NI+ L + ++D    Y+V E ++GG +L  I +QK F+EREAS V+  +   +++LH
Sbjct: 472 QHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLH 531

Query: 163 TKGIAHRDLKPENIL-CESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEY 221
            +G+ HRDLKP NIL  +       ++ICDF     ++  N         L TPC +A +
Sbjct: 532 AQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGL-------LMTPCYTANF 584

Query: 222 MAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQN 281
           +APEV+     +   YD  CD+WSLGV+LY ML+GY PF    G D   D  E       
Sbjct: 585 VAPEVL-----KRQGYDAACDIWSLGVLLYTMLTGYTPFAN--GPD---DTPE------- 627

Query: 282 KLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKG 341
           ++   I  GK+      W  +S  AKDL+SK+L  D  QRL+AA VL+HPW+        
Sbjct: 628 EILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWI---VHWDQ 684

Query: 342 LPTPQVLQRNSSTMDLTLFAAEAIALNRQLS 372
           LP  Q+ ++++  +     AA   ALNR  S
Sbjct: 685 LPQYQLNRQDAPHLVKGAMAATYSALNRNQS 715



 Score =  103 bits (258), Expect = 2e-22
 Identities = 85/288 (29%), Positives = 143/288 (49%), Gaps = 43/288 (14%)

Query: 41  PGKFEDMYKLTSELLGEGAYAKV--QGAVSLQNGKE-YAVKIIEKQAGHSRSRVFREVET 97
           P +FE +     ++LG+G++ KV     +S  + ++ YA+K+++K     R RV  ++E 
Sbjct: 65  PSQFELL-----KVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMER 119

Query: 98  LYQCQGNKNILELIEF-FEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAA 156
               + N   +  + + F+ + + YL+ + L+GG +   + K+  F E +    + ++A 
Sbjct: 120 DILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL 179

Query: 157 ALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPC 216
           ALD LH+ GI +RDLKPENIL    ++   +K+ DF L S   +++        +  + C
Sbjct: 180 ALDHLHSLGIIYRDLKPENILL---DEEGHIKLTDFGL-SKESIDHE------KKAYSFC 229

Query: 217 GSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVC 276
           G+ EYMAPEVV         + +  D WS GV+++ ML+G  PF G        DR E  
Sbjct: 230 GTVEYMAPEVV-----NRRGHTQSADWWSFGVLMFEMLTGTLPFQGK-------DRKETM 277

Query: 277 RVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSA 324
            +        I + K   P      +S EA+ L+  L  R+   RL A
Sbjct: 278 TM--------ILKAKLGMPQ----FLSPEAQSLLRMLFKRNPANRLGA 313


>gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo
           sapiens]
          Length = 476

 Score =  178 bits (452), Expect = 7e-45
 Identities = 104/283 (36%), Positives = 155/283 (54%), Gaps = 30/283 (10%)

Query: 53  ELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIE 112
           E+LG GA+++V        GK +A+K I+K      S +  E+  L + + ++NI+ L +
Sbjct: 27  EVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLENEIAVLKKIK-HENIVTLED 85

Query: 113 FFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAHRDLK 172
            +E  T +YLV + + GG +   I ++  + E++AS V++ V +A+ +LH  GI HRDLK
Sbjct: 86  IYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLK 145

Query: 173 PENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTD 232
           PEN+L  +PE+ S + I DF L S M+ N          ++T CG+  Y+APEV+     
Sbjct: 146 PENLLYLTPEENSKIMITDFGL-SKMEQNGI--------MSTACGTPGYVAPEVL----- 191

Query: 233 QATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKY 292
               Y K  D WS+GV+ YI+L GYPPF                   ++KLFE I+EG Y
Sbjct: 192 AQKPYSKAVDCWSIGVITYILLCGYPPFY---------------EETESKLFEKIKEGYY 236

Query: 293 EFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQG 335
           EF    W  IS  AKD I  LL +D  +R +  + L HPW+ G
Sbjct: 237 EFESPFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWIDG 279


>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
          Length = 745

 Score =  172 bits (437), Expect = 4e-43
 Identities = 104/292 (35%), Positives = 160/292 (54%), Gaps = 30/292 (10%)

Query: 43  KFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQ 102
           +F ++Y+L  ++ G G+Y+  +  +      E+AVKII+K    S+     E+E L +  
Sbjct: 421 QFGEVYELKEDI-GVGSYSVCKRCIHATTNMEFAVKIIDK----SKRDPSEEIEILMRYG 475

Query: 103 GNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLH 162
            + NI+ L + F+D    YLV + ++GG +L  I KQK F+EREAS ++  ++  +D+LH
Sbjct: 476 QHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLH 535

Query: 163 TKGIAHRDLKPENIL-CESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEY 221
            +G+ HRDLKP NIL  +       ++ICDF     ++  N         L TPC +A +
Sbjct: 536 CQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGL-------LLTPCYTANF 588

Query: 222 MAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQN 281
           +APEV+         YD  CD+WSLGV+ Y ML+GY PF     A+   D  E       
Sbjct: 589 VAPEVL-----MQQGYDAACDIWSLGVLFYTMLAGYTPF-----ANGPNDTPE------- 631

Query: 282 KLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWV 333
           ++   I  GK+     +W +IS  AKDL+S +L  D  QR +A Q+L+H W+
Sbjct: 632 EILLRIGNGKFSLSGGNWDNISDGAKDLLSHMLHMDPHQRYTAEQILKHSWI 683



 Score =  108 bits (270), Expect = 9e-24
 Identities = 84/291 (28%), Positives = 141/291 (48%), Gaps = 43/291 (14%)

Query: 41  PGKFEDMYKLTSELLGEGAYAKV---QGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVET 97
           P +FE +     ++LG+G++ KV   +       G+ YA+K+++K +   R RV  ++E 
Sbjct: 70  PAQFELL-----KVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMER 124

Query: 98  LYQCQGNKNILELIEF-FEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAA 156
               + N   +  + + F+ + + YL+ + L+GG +   + K+  F E +    + ++A 
Sbjct: 125 DILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELAL 184

Query: 157 ALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPC 216
           ALD LH  GI +RDLKPENIL    +++  +K+ DF L          +     +  + C
Sbjct: 185 ALDHLHQLGIVYRDLKPENILL---DEIGHIKLTDFGLSKE-------SVDQEKKAYSFC 234

Query: 217 GSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVC 276
           G+ EYMAPEVV         + +  D WS GV+++ ML+G  PF G        DR    
Sbjct: 235 GTVEYMAPEVV-----NRRGHSQSADWWSYGVLMFEMLTGTLPFQGK-------DR---- 278

Query: 277 RVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQV 327
               N+    I + K   P      +S+EA+ L+  L  R+   RL +  V
Sbjct: 279 ----NETMNMILKAKLGMPQ----FLSAEAQSLLRMLFKRNPANRLGSEGV 321


>gi|4758128 doublecortin-like kinase 1 [Homo sapiens]
          Length = 729

 Score =  172 bits (436), Expect = 5e-43
 Identities = 104/305 (34%), Positives = 163/305 (53%), Gaps = 34/305 (11%)

Query: 40  LPGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLY 99
           +P    + YK+    +G+G +A V+  V     +EYA+KII+K     +  + +   ++ 
Sbjct: 382 IPATITERYKV-GRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSIL 440

Query: 100 QCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALD 159
           +   + NI+ LIE  +  T  YLV E ++GG +   I     + ER+AS ++ ++A+A+ 
Sbjct: 441 RRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIK 500

Query: 160 FLHTKGIAHRDLKPENILC-ESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGS 218
           +LH+  I HRD+KPEN+L  E  +    +K+ DF L +          I    L T CG+
Sbjct: 501 YLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLAT----------IVDGPLYTVCGT 550

Query: 219 AEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRV 278
             Y+APE++       T Y  + D+W+ GV+ YI+L G+PPF G  G D           
Sbjct: 551 PTYVAPEII-----AETGYGLKVDIWAAGVITYILLCGFPPFRG-SGDD----------- 593

Query: 279 CQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAP 338
            Q  LF+ I  G+ +FP   W ++S  AK+LI+ +L+ D  QR SA QVL+HPWV     
Sbjct: 594 -QEVLFDQILMGQVDFPSPYWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWVN---- 648

Query: 339 EKGLP 343
           + GLP
Sbjct: 649 DDGLP 653


>gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens]
          Length = 765

 Score =  172 bits (435), Expect = 7e-43
 Identities = 113/361 (31%), Positives = 178/361 (49%), Gaps = 53/361 (14%)

Query: 4   SQKLEKPIEMGSSEPLPIADGDRRRKK-KRRGRATDSLPGKFE----------------- 45
           S +L  P    SS   P + G  R  K    GR++ ++ G  E                 
Sbjct: 326 SSQLSTPKSTKSSSSSPTSPGSFRGLKISAHGRSSSNVNGGPELDRCISPEGVNGNRCSE 385

Query: 46  -----DMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQ 100
                + YK+  +++G+G +A V+  +    GKE+A+KII+K     +  +     ++ +
Sbjct: 386 SSTLLEKYKI-GKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHLIENEVSILR 444

Query: 101 CQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDF 160
              + NI+ L+E  E  T  +LV E ++GG +   I     + ER+ S +V ++A AL +
Sbjct: 445 RVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRY 504

Query: 161 LHTKGIAHRDLKPENIL-CESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSA 219
           LH   I HRD+KPEN+L CE P+    +K+ DF L +          +    L T CG+ 
Sbjct: 505 LHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLAT----------VVEGPLYTVCGTP 554

Query: 220 EYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVC 279
            Y+APE++       T Y  + D+W+ GV+ YI+L G+PPF           R E     
Sbjct: 555 TYVAPEII-----AETGYGLKVDIWAAGVITYILLCGFPPF-----------RSE--NNL 596

Query: 280 QNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPE 339
           Q  LF+ I  GK EFP   W +I+  AK+LIS++L  + + R +A Q+L HPWV   A +
Sbjct: 597 QEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDASQ 656

Query: 340 K 340
           +
Sbjct: 657 E 657


>gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens]
          Length = 766

 Score =  172 bits (435), Expect = 7e-43
 Identities = 113/362 (31%), Positives = 179/362 (49%), Gaps = 54/362 (14%)

Query: 4   SQKLEKPIEMGSSEPLPIADGDRRRKKK--RRGRATDSLPGKFE---------------- 45
           S +L  P    SS   P + G  R  K+    GR++ ++ G  E                
Sbjct: 326 SSQLSTPKSTKSSSSSPTSPGSFRGLKQISAHGRSSSNVNGGPELDRCISPEGVNGNRCS 385

Query: 46  ------DMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLY 99
                 + YK+  +++G+G +A V+  +    GKE+A+KII+K     +  +     ++ 
Sbjct: 386 ESSTLLEKYKI-GKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHLIENEVSIL 444

Query: 100 QCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALD 159
           +   + NI+ L+E  E  T  +LV E ++GG +   I     + ER+ S +V ++A AL 
Sbjct: 445 RRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALR 504

Query: 160 FLHTKGIAHRDLKPENIL-CESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGS 218
           +LH   I HRD+KPEN+L CE P+    +K+ DF L +          +    L T CG+
Sbjct: 505 YLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLAT----------VVEGPLYTVCGT 554

Query: 219 AEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRV 278
             Y+APE++       T Y  + D+W+ GV+ YI+L G+PPF           R E    
Sbjct: 555 PTYVAPEII-----AETGYGLKVDIWAAGVITYILLCGFPPF-----------RSE--NN 596

Query: 279 CQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAP 338
            Q  LF+ I  GK EFP   W +I+  AK+LIS++L  + + R +A Q+L HPWV   A 
Sbjct: 597 LQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDAS 656

Query: 339 EK 340
           ++
Sbjct: 657 QE 658


>gi|21237768 MAP kinase-activated protein kinase 5 isoform 2 [Homo
           sapiens]
          Length = 473

 Score =  171 bits (432), Expect = 2e-42
 Identities = 107/339 (31%), Positives = 167/339 (49%), Gaps = 49/339 (14%)

Query: 52  SELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELI 111
           ++ LG G    V+  V     + +A+KI+       R +   EV     C  + NI+++I
Sbjct: 25  TQKLGAGISGPVRVCVKKSTQERFALKILL-----DRPKARNEVRLHMMCATHPNIVQII 79

Query: 112 EFFEDDTRF----------YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFL 161
           E F +  +F           +V E ++GG +   I + +HF E++AS+V + +A AL   
Sbjct: 80  EVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQIALALRHC 139

Query: 162 HTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEY 221
           H   IAHRDLKPEN+L +     +PVK+CDF              I   +L TP  +  Y
Sbjct: 140 HLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAK----------IDQGDLMTPQFTPYY 189

Query: 222 MAPEVVE------------VFTDQATF-YDKRCDLWSLGVVLYIMLSGYPPFVGHCGADC 268
           +AP+V+E            + T    + Y+K CDLWSLGV++Y+ML GYPPF        
Sbjct: 190 VAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSK----- 244

Query: 269 GWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVL 328
                   R     +   I  G +EFP+++W+ IS  AKD++ KLL    ++RL+   VL
Sbjct: 245 -----HHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVL 299

Query: 329 QHPWVQG-QAPEKGLPTPQVLQRNSSTMDLTLFAAEAIA 366
            HPW+   +A +  LP+ Q++   +    +    AE +A
Sbjct: 300 DHPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLA 338


>gi|21237765 MAP kinase-activated protein kinase 5 isoform 1 [Homo
           sapiens]
          Length = 471

 Score =  171 bits (432), Expect = 2e-42
 Identities = 107/339 (31%), Positives = 167/339 (49%), Gaps = 49/339 (14%)

Query: 52  SELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELI 111
           ++ LG G    V+  V     + +A+KI+       R +   EV     C  + NI+++I
Sbjct: 25  TQKLGAGISGPVRVCVKKSTQERFALKILL-----DRPKARNEVRLHMMCATHPNIVQII 79

Query: 112 EFFEDDTRF----------YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFL 161
           E F +  +F           +V E ++GG +   I + +HF E++AS+V + +A AL   
Sbjct: 80  EVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQIALALRHC 139

Query: 162 HTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEY 221
           H   IAHRDLKPEN+L +     +PVK+CDF              I   +L TP  +  Y
Sbjct: 140 HLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAK----------IDQGDLMTPQFTPYY 189

Query: 222 MAPEVVE------------VFTDQATF-YDKRCDLWSLGVVLYIMLSGYPPFVGHCGADC 268
           +AP+V+E            + T    + Y+K CDLWSLGV++Y+ML GYPPF        
Sbjct: 190 VAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSK----- 244

Query: 269 GWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVL 328
                   R     +   I  G +EFP+++W+ IS  AKD++ KLL    ++RL+   VL
Sbjct: 245 -----HHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVL 299

Query: 329 QHPWVQG-QAPEKGLPTPQVLQRNSSTMDLTLFAAEAIA 366
            HPW+   +A +  LP+ Q++   +    +    AE +A
Sbjct: 300 DHPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLA 338


>gi|32481209 mitogen-activated protein kinase-activated protein
           kinase 2 isoform 2 [Homo sapiens]
          Length = 400

 Score =  170 bits (430), Expect = 3e-42
 Identities = 103/314 (32%), Positives = 169/314 (53%), Gaps = 37/314 (11%)

Query: 46  DMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNK 105
           D YK+TS++LG G   KV    + +  +++A+K+++        +  REVE  ++     
Sbjct: 61  DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-----DCPKARREVELHWRASQCP 115

Query: 106 NILELIEFFED----DTRFYLVFEKLQGGSILAHIQKQ--KHFNEREASRVVRDVAAALD 159
           +I+ +++ +E+         +V E L GG + + IQ +  + F EREAS +++ +  A+ 
Sbjct: 116 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175

Query: 160 FLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSA 219
           +LH+  IAHRD+KPEN+L  S    + +K+ DF        +NS        LTTPC + 
Sbjct: 176 YLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS--------LTTPCYTP 227

Query: 220 EYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVC 279
            Y+APEV+         YDK CD+WSLGV++YI+L GYPPF  + G              
Sbjct: 228 YYVAPEVL-----GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL-----------AI 271

Query: 280 QNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWV--QGQA 337
              +   I+ G+YEFP+ +W+ +S E K LI  LL  +  QR++  + + HPW+    + 
Sbjct: 272 SPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKV 331

Query: 338 PEKGLPTPQVLQRN 351
           P+  L T +VL+ +
Sbjct: 332 PQTPLHTSRVLKED 345


>gi|10863901 mitogen-activated protein kinase-activated protein
           kinase 2 isoform 1 [Homo sapiens]
          Length = 370

 Score =  170 bits (430), Expect = 3e-42
 Identities = 103/314 (32%), Positives = 169/314 (53%), Gaps = 37/314 (11%)

Query: 46  DMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNK 105
           D YK+TS++LG G   KV    + +  +++A+K+++        +  REVE  ++     
Sbjct: 61  DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-----DCPKARREVELHWRASQCP 115

Query: 106 NILELIEFFED----DTRFYLVFEKLQGGSILAHIQKQ--KHFNEREASRVVRDVAAALD 159
           +I+ +++ +E+         +V E L GG + + IQ +  + F EREAS +++ +  A+ 
Sbjct: 116 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175

Query: 160 FLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSA 219
           +LH+  IAHRD+KPEN+L  S    + +K+ DF        +NS        LTTPC + 
Sbjct: 176 YLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS--------LTTPCYTP 227

Query: 220 EYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVC 279
            Y+APEV+         YDK CD+WSLGV++YI+L GYPPF  + G              
Sbjct: 228 YYVAPEVL-----GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL-----------AI 271

Query: 280 QNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWV--QGQA 337
              +   I+ G+YEFP+ +W+ +S E K LI  LL  +  QR++  + + HPW+    + 
Sbjct: 272 SPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKV 331

Query: 338 PEKGLPTPQVLQRN 351
           P+  L T +VL+ +
Sbjct: 332 PQTPLHTSRVLKED 345


>gi|27901803 protein serine kinase H1 [Homo sapiens]
          Length = 424

 Score =  170 bits (430), Expect = 3e-42
 Identities = 117/378 (30%), Positives = 180/378 (47%), Gaps = 40/378 (10%)

Query: 10  PIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAYAKVQGAVSL 69
           P   G +EP P     R R  K R +    +  K++        L+G G++++V      
Sbjct: 65  PPTAGHTEP-PSEPPRRARVAKYRAKFDPRVTAKYD-----IKALIGRGSFSRVVRVEHR 118

Query: 70  QNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQG 129
              + YA+K+IE +    R     E+  L + + + NI++L+E FE   R Y+V E   G
Sbjct: 119 ATRQPYAIKMIETKYREGREVCESELRVLRRVR-HANIIQLVEVFETQERVYMVMELATG 177

Query: 130 GSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAHRDLKPENILCESPEKVSPVKI 189
           G +   I  +  F ER+A+RV++ V   + +LH  GI HRDLKPEN+L   P   S + I
Sbjct: 178 GELFDRIIAKGSFTERDATRVLQMVLDGVRYLHALGITHRDLKPENLLYYHPGTDSKIII 237

Query: 190 CDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVV 249
            DF L S  K  + C       + T CG+ EY+APEV+         Y    D+W+LGV+
Sbjct: 238 TDFGLASARKKGDDCL------MKTTCGTPEYIAPEVL-----VRKPYTNSVDMWALGVI 286

Query: 250 LYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDL 309
            YI+LSG  PF                   + +L+  I  GKY +  + W  +S+ AKD 
Sbjct: 287 AYILLSGTMPFEDD---------------NRTRLYRQILRGKYSYSGEPWPSVSNLAKDF 331

Query: 310 ISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLP------TPQVLQRNSSTMDLTLFAAE 363
           I +LL  D   R++A Q L+HPWV   A    +       +  +L+R SS    T  +A+
Sbjct: 332 IDRLLTVDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQNLLKRASSRCQSTK-SAQ 390

Query: 364 AIALNRQLSQHEENELAE 381
           +   +R    ++   + E
Sbjct: 391 STRSSRSTRSNKSRRVRE 408


>gi|9966875 calcium/calmodulin-dependent protein kinase ID isoform 1
           [Homo sapiens]
          Length = 357

 Score =  169 bits (429), Expect = 3e-42
 Identities = 107/308 (34%), Positives = 164/308 (53%), Gaps = 32/308 (10%)

Query: 31  KRRGRATDSLPGKFEDMYKLTS--ELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSR 88
           +  G ++ S   + ED+ K+    E LG GA+++V  A     GK +AVK I K+A   +
Sbjct: 3   RENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGK 62

Query: 89  -SRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREA 147
            S +  E+  L + + ++NI+ L + +E     YLV + + GG +   I ++  + E++A
Sbjct: 63  ESSIENEIAVLRKIK-HENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDA 121

Query: 148 SRVVRDVAAALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPI 207
           S ++R V  A+ +LH  GI HRDLKPEN+L  S ++ S + I DF L S M+        
Sbjct: 122 STLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGL-SKMEGKGDV--- 177

Query: 208 TTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGAD 267
               ++T CG+  Y+APEV+         Y K  D WS+GV+ YI+L GYPPF       
Sbjct: 178 ----MSTACGTPGYVAPEVL-----AQKPYSKAVDCWSIGVIAYILLCGYPPF------- 221

Query: 268 CGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQV 327
             +D  +      +KLFE I + +YEF    W  IS  AKD I  L+ +D  +R +  Q 
Sbjct: 222 --YDEND------SKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQA 273

Query: 328 LQHPWVQG 335
            +HPW+ G
Sbjct: 274 ARHPWIAG 281


>gi|23943850 calcium/calmodulin-dependent protein kinase ID isoform
           2 [Homo sapiens]
          Length = 385

 Score =  169 bits (429), Expect = 3e-42
 Identities = 107/308 (34%), Positives = 164/308 (53%), Gaps = 32/308 (10%)

Query: 31  KRRGRATDSLPGKFEDMYKLTS--ELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSR 88
           +  G ++ S   + ED+ K+    E LG GA+++V  A     GK +AVK I K+A   +
Sbjct: 3   RENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGK 62

Query: 89  -SRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREA 147
            S +  E+  L + + ++NI+ L + +E     YLV + + GG +   I ++  + E++A
Sbjct: 63  ESSIENEIAVLRKIK-HENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDA 121

Query: 148 SRVVRDVAAALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPI 207
           S ++R V  A+ +LH  GI HRDLKPEN+L  S ++ S + I DF L S M+        
Sbjct: 122 STLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGL-SKMEGKGDV--- 177

Query: 208 TTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGAD 267
               ++T CG+  Y+APEV+         Y K  D WS+GV+ YI+L GYPPF       
Sbjct: 178 ----MSTACGTPGYVAPEVL-----AQKPYSKAVDCWSIGVIAYILLCGYPPF------- 221

Query: 268 CGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQV 327
             +D  +      +KLFE I + +YEF    W  IS  AKD I  L+ +D  +R +  Q 
Sbjct: 222 --YDEND------SKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQA 273

Query: 328 LQHPWVQG 335
            +HPW+ G
Sbjct: 274 ARHPWIAG 281


>gi|212549756 calcium/calmodulin-dependent protein kinase II delta
           isoform 4 [Homo sapiens]
          Length = 489

 Score =  168 bits (426), Expect = 7e-42
 Identities = 96/293 (32%), Positives = 165/293 (56%), Gaps = 31/293 (10%)

Query: 43  KFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKII--EKQAGHSRSRVFREVETLYQ 100
           +F D Y+L  EL G+GA++ V+  + +  G+EYA KII  +K +     ++ RE   + +
Sbjct: 9   RFTDEYQLFEEL-GKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREAR-ICR 66

Query: 101 CQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDF 160
              + NI+ L +   ++   YLVF+ + GG +   I  +++++E +AS  ++ +  +++ 
Sbjct: 67  LLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNH 126

Query: 161 LHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAE 220
            H  GI HRDLKPEN+L  S  K + VK+ DF L   ++ +               G+  
Sbjct: 127 CHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQA-------WFGFAGTPG 179

Query: 221 YMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQ 280
           Y++PEV+     +   Y K  D+W+ GV+LYI+L GYPPF         WD        Q
Sbjct: 180 YLSPEVL-----RKDPYGKPVDMWACGVILYILLVGYPPF---------WDED------Q 219

Query: 281 NKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWV 333
           ++L++ I+ G Y+FP  +W  ++ EAKDLI+K+L  +  +R++A++ L+HPW+
Sbjct: 220 HRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272


>gi|26667183 calcium/calmodulin-dependent protein kinase II delta
           isoform 1 [Homo sapiens]
          Length = 478

 Score =  168 bits (426), Expect = 7e-42
 Identities = 96/293 (32%), Positives = 165/293 (56%), Gaps = 31/293 (10%)

Query: 43  KFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKII--EKQAGHSRSRVFREVETLYQ 100
           +F D Y+L  EL G+GA++ V+  + +  G+EYA KII  +K +     ++ RE   + +
Sbjct: 9   RFTDEYQLFEEL-GKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREAR-ICR 66

Query: 101 CQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDF 160
              + NI+ L +   ++   YLVF+ + GG +   I  +++++E +AS  ++ +  +++ 
Sbjct: 67  LLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNH 126

Query: 161 LHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAE 220
            H  GI HRDLKPEN+L  S  K + VK+ DF L   ++ +               G+  
Sbjct: 127 CHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQA-------WFGFAGTPG 179

Query: 221 YMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQ 280
           Y++PEV+     +   Y K  D+W+ GV+LYI+L GYPPF         WD        Q
Sbjct: 180 YLSPEVL-----RKDPYGKPVDMWACGVILYILLVGYPPF---------WDED------Q 219

Query: 281 NKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWV 333
           ++L++ I+ G Y+FP  +W  ++ EAKDLI+K+L  +  +R++A++ L+HPW+
Sbjct: 220 HRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272


>gi|212549753 calcium/calmodulin-dependent protein kinase II delta
           isoform 5 [Homo sapiens]
          Length = 492

 Score =  168 bits (426), Expect = 7e-42
 Identities = 96/293 (32%), Positives = 165/293 (56%), Gaps = 31/293 (10%)

Query: 43  KFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKII--EKQAGHSRSRVFREVETLYQ 100
           +F D Y+L  EL G+GA++ V+  + +  G+EYA KII  +K +     ++ RE   + +
Sbjct: 9   RFTDEYQLFEEL-GKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREAR-ICR 66

Query: 101 CQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDF 160
              + NI+ L +   ++   YLVF+ + GG +   I  +++++E +AS  ++ +  +++ 
Sbjct: 67  LLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNH 126

Query: 161 LHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAE 220
            H  GI HRDLKPEN+L  S  K + VK+ DF L   ++ +               G+  
Sbjct: 127 CHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQA-------WFGFAGTPG 179

Query: 221 YMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQ 280
           Y++PEV+     +   Y K  D+W+ GV+LYI+L GYPPF         WD        Q
Sbjct: 180 YLSPEVL-----RKDPYGKPVDMWACGVILYILLVGYPPF---------WDED------Q 219

Query: 281 NKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWV 333
           ++L++ I+ G Y+FP  +W  ++ EAKDLI+K+L  +  +R++A++ L+HPW+
Sbjct: 220 HRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272


>gi|26667186 calcium/calmodulin-dependent protein kinase II delta
           isoform 1 [Homo sapiens]
          Length = 478

 Score =  168 bits (426), Expect = 7e-42
 Identities = 96/293 (32%), Positives = 165/293 (56%), Gaps = 31/293 (10%)

Query: 43  KFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKII--EKQAGHSRSRVFREVETLYQ 100
           +F D Y+L  EL G+GA++ V+  + +  G+EYA KII  +K +     ++ RE   + +
Sbjct: 9   RFTDEYQLFEEL-GKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREAR-ICR 66

Query: 101 CQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDF 160
              + NI+ L +   ++   YLVF+ + GG +   I  +++++E +AS  ++ +  +++ 
Sbjct: 67  LLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNH 126

Query: 161 LHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAE 220
            H  GI HRDLKPEN+L  S  K + VK+ DF L   ++ +               G+  
Sbjct: 127 CHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQA-------WFGFAGTPG 179

Query: 221 YMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQ 280
           Y++PEV+     +   Y K  D+W+ GV+LYI+L GYPPF         WD        Q
Sbjct: 180 YLSPEVL-----RKDPYGKPVDMWACGVILYILLVGYPPF---------WDED------Q 219

Query: 281 NKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWV 333
           ++L++ I+ G Y+FP  +W  ++ EAKDLI+K+L  +  +R++A++ L+HPW+
Sbjct: 220 HRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.134    0.395 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,166,653
Number of Sequences: 37866
Number of extensions: 775906
Number of successful extensions: 4453
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 548
Number of HSP's successfully gapped in prelim test: 225
Number of HSP's that attempted gapping in prelim test: 2275
Number of HSP's gapped (non-prelim): 971
length of query: 424
length of database: 18,247,518
effective HSP length: 105
effective length of query: 319
effective length of database: 14,271,588
effective search space: 4552636572
effective search space used: 4552636572
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.