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Search of human proteins with 11342664
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|11342664 myxovirus resistance protein 2 [Homo sapiens]
(715 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|11342664 myxovirus resistance protein 2 [Homo sapiens] 1418 0.0
gi|222136619 myxovirus resistance protein 1 [Homo sapiens] 771 0.0
gi|222136617 myxovirus resistance protein 1 [Homo sapiens] 771 0.0
gi|56549121 dynamin 2 isoform 1 [Homo sapiens] 224 3e-58
gi|56549119 dynamin 2 isoform 3 [Homo sapiens] 224 3e-58
gi|56549125 dynamin 2 isoform 4 [Homo sapiens] 223 5e-58
gi|56549123 dynamin 2 isoform 2 [Homo sapiens] 223 5e-58
gi|42544243 dynamin 3 isoform a [Homo sapiens] 219 7e-57
gi|209915561 dynamin 3 isoform b [Homo sapiens] 219 7e-57
gi|56549117 dynamin 1 isoform 2 [Homo sapiens] 215 1e-55
gi|59853099 dynamin 1 isoform 1 [Homo sapiens] 215 1e-55
gi|171460914 dynamin 1-like isoform 1 [Homo sapiens] 196 8e-50
gi|171460918 dynamin 1-like isoform 3 [Homo sapiens] 196 8e-50
gi|171460916 dynamin 1-like isoform 2 [Homo sapiens] 196 8e-50
gi|224831253 optic atrophy 1 isoform 8 [Homo sapiens] 99 2e-20
gi|224831251 optic atrophy 1 isoform 7 [Homo sapiens] 99 2e-20
gi|18860841 optic atrophy 1 isoform 6 [Homo sapiens] 99 2e-20
gi|224831248 optic atrophy 1 isoform 5 [Homo sapiens] 99 2e-20
gi|18860835 optic atrophy 1 isoform 4 [Homo sapiens] 99 2e-20
gi|18860833 optic atrophy 1 isoform 3 [Homo sapiens] 99 2e-20
gi|18860831 optic atrophy 1 isoform 2 [Homo sapiens] 99 2e-20
gi|224831243 optic atrophy 1 isoform 1 [Homo sapiens] 99 2e-20
gi|82880656 coiled-coil domain containing 46 isoform a [Homo sap... 38 0.029
gi|4503917 growth arrest-specific 8 [Homo sapiens] 38 0.029
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 37 0.064
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr... 37 0.064
gi|21735548 centrosomal protein 2 [Homo sapiens] 37 0.083
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 35 0.19
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 35 0.19
gi|117968420 NUF2, NDC80 kinetochore complex component [Homo sap... 35 0.19
>gi|11342664 myxovirus resistance protein 2 [Homo sapiens]
Length = 715
Score = 1418 bits (3671), Expect = 0.0
Identities = 715/715 (100%), Positives = 715/715 (100%)
Query: 1 MSKAHKPWPYRRRSQFSSRKYLKKEMNSFQQQPPPFGTVPPQMMFPPNWQGAEKDAAFLA 60
MSKAHKPWPYRRRSQFSSRKYLKKEMNSFQQQPPPFGTVPPQMMFPPNWQGAEKDAAFLA
Sbjct: 1 MSKAHKPWPYRRRSQFSSRKYLKKEMNSFQQQPPPFGTVPPQMMFPPNWQGAEKDAAFLA 60
Query: 61 KDFNFLTLNNQPPPGNRSQPRAMGPENNLYSQYEQKVRPCIDLIDSLRALGVEQDLALPA 120
KDFNFLTLNNQPPPGNRSQPRAMGPENNLYSQYEQKVRPCIDLIDSLRALGVEQDLALPA
Sbjct: 61 KDFNFLTLNNQPPPGNRSQPRAMGPENNLYSQYEQKVRPCIDLIDSLRALGVEQDLALPA 120
Query: 121 IAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKLKKQPCEAWAGRISYRNTELEL 180
IAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKLKKQPCEAWAGRISYRNTELEL
Sbjct: 121 IAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKLKKQPCEAWAGRISYRNTELEL 180
Query: 181 QDPGQVEKEIHKAQNVMAGNGRGISHELISLEITSPEVPDLTIIDLPGITRVAVDNQPRD 240
QDPGQVEKEIHKAQNVMAGNGRGISHELISLEITSPEVPDLTIIDLPGITRVAVDNQPRD
Sbjct: 181 QDPGQVEKEIHKAQNVMAGNGRGISHELISLEITSPEVPDLTIIDLPGITRVAVDNQPRD 240
Query: 241 IGLQIKALIKKYIQRQQTINLVVVPCNVDIATTEALSMAHEVDPEGDRTIGILTKPDLMD 300
IGLQIKALIKKYIQRQQTINLVVVPCNVDIATTEALSMAHEVDPEGDRTIGILTKPDLMD
Sbjct: 241 IGLQIKALIKKYIQRQQTINLVVVPCNVDIATTEALSMAHEVDPEGDRTIGILTKPDLMD 300
Query: 301 RGTEKSVMNVVRNLTYPLKKGYMIVKCRGQQEITNRLSLAEATKKEITFFQTHPYFRVLL 360
RGTEKSVMNVVRNLTYPLKKGYMIVKCRGQQEITNRLSLAEATKKEITFFQTHPYFRVLL
Sbjct: 301 RGTEKSVMNVVRNLTYPLKKGYMIVKCRGQQEITNRLSLAEATKKEITFFQTHPYFRVLL 360
Query: 361 EEGSATVPRLAERLTTELIMHIQKSLPLLEGQIRESHQKATEELRRCGADIPSQEADKMF 420
EEGSATVPRLAERLTTELIMHIQKSLPLLEGQIRESHQKATEELRRCGADIPSQEADKMF
Sbjct: 361 EEGSATVPRLAERLTTELIMHIQKSLPLLEGQIRESHQKATEELRRCGADIPSQEADKMF 420
Query: 421 FLIEKIKMFNQDIEKLVEGEEVVRENETRLYNKIREDFKNWVGILATNTQKVKNIIHEEV 480
FLIEKIKMFNQDIEKLVEGEEVVRENETRLYNKIREDFKNWVGILATNTQKVKNIIHEEV
Sbjct: 421 FLIEKIKMFNQDIEKLVEGEEVVRENETRLYNKIREDFKNWVGILATNTQKVKNIIHEEV 480
Query: 481 EKYEKQYRGKELLGFVNYKTFEIIVHQYIQQLVEPALSMLQKAMEIIQQAFINVAKKHFG 540
EKYEKQYRGKELLGFVNYKTFEIIVHQYIQQLVEPALSMLQKAMEIIQQAFINVAKKHFG
Sbjct: 481 EKYEKQYRGKELLGFVNYKTFEIIVHQYIQQLVEPALSMLQKAMEIIQQAFINVAKKHFG 540
Query: 541 EFFNLNQTVQSTIEDIKVKHTAKAENMIQLQFRMEQMVFCQDQIYSVVLKKVREEIFNPL 600
EFFNLNQTVQSTIEDIKVKHTAKAENMIQLQFRMEQMVFCQDQIYSVVLKKVREEIFNPL
Sbjct: 541 EFFNLNQTVQSTIEDIKVKHTAKAENMIQLQFRMEQMVFCQDQIYSVVLKKVREEIFNPL 600
Query: 601 GTPSQNMKLNSHFPSNESSVSSFTEIGIHLNAYFLETSKRLANQIPFIIQYFMLRENGDS 660
GTPSQNMKLNSHFPSNESSVSSFTEIGIHLNAYFLETSKRLANQIPFIIQYFMLRENGDS
Sbjct: 601 GTPSQNMKLNSHFPSNESSVSSFTEIGIHLNAYFLETSKRLANQIPFIIQYFMLRENGDS 660
Query: 661 LQKAMMQILQEKNRYSWLLQEQSETATKRRILKERIYRLTQARHALCQFSSKEIH 715
LQKAMMQILQEKNRYSWLLQEQSETATKRRILKERIYRLTQARHALCQFSSKEIH
Sbjct: 661 LQKAMMQILQEKNRYSWLLQEQSETATKRRILKERIYRLTQARHALCQFSSKEIH 715
>gi|222136619 myxovirus resistance protein 1 [Homo sapiens]
Length = 662
Score = 771 bits (1992), Expect = 0.0
Identities = 399/626 (63%), Positives = 495/626 (79%), Gaps = 5/626 (0%)
Query: 86 ENNLYSQYEQKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPR 145
ENNL SQYE+KVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPR
Sbjct: 38 ENNLCSQYEEKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPR 97
Query: 146 GSGIVTRCPLVLKLKKQPCE-AWAGRISYRNTELELQDPGQVEKEIHKAQNVMAGNGRGI 204
GSGIVTRCPLVLKLKK E W G++SY++ E+E+ D +VEKEI+KAQN +AG G GI
Sbjct: 98 GSGIVTRCPLVLKLKKLVNEDKWRGKVSYQDYEIEISDASEVEKEINKAQNAIAGEGMGI 157
Query: 205 SHELISLEITSPEVPDLTIIDLPGITRVAVDNQPRDIGLQIKALIKKYIQRQQTINLVVV 264
SHELI+LEI+S +VPDLT+IDLPGITRVAV NQP DIG +IK LIKKYIQRQ+TI+LVVV
Sbjct: 158 SHELITLEISSRDVPDLTLIDLPGITRVAVGNQPADIGYKIKTLIKKYIQRQETISLVVV 217
Query: 265 PCNVDIATTEALSMAHEVDPEGDRTIGILTKPDLMDRGTEKSVMNVVRNLTYPLKKGYMI 324
P NVDIATTEALSMA EVDPEGDRTIGILTKPDL+D+GTE V++VVRNL + LKKGYMI
Sbjct: 218 PSNVDIATTEALSMAQEVDPEGDRTIGILTKPDLVDKGTEDKVVDVVRNLVFHLKKGYMI 277
Query: 325 VKCRGQQEITNRLSLAEATKKEITFFQTHPYFRVLLEEGSATVPRLAERLTTELIMHIQK 384
VKCRGQQEI ++LSL+EA ++E FF+ HPYFR LLEEG ATVP LAE+LT+ELI HI K
Sbjct: 278 VKCRGQQEIQDQLSLSEALQREKIFFENHPYFRDLLEEGKATVPCLAEKLTSELITHICK 337
Query: 385 SLPLLEGQIRESHQKATEELRRCGADIPSQEADKMFFLIEKIKMFNQDIEKLVEGEEVVR 444
SLPLLE QI+E+HQ+ TEEL++ G DIP E +KMFFLI+K+ FNQDI L++GEE V
Sbjct: 338 SLPLLENQIKETHQRITEELQKYGVDIPEDENEKMFFLIDKVNAFNQDITALMQGEETVG 397
Query: 445 ENETRLYNKIREDFKNWVGILATNTQKVKNIIHEEVEKYEKQYRGKELLGFVNYKTFEII 504
E + RL+ ++R +F W I+ N Q+ I+ +++K+E QYRG+EL GFVNY+TFE I
Sbjct: 398 EEDIRLFTRLRHEFHKWSTIIENNFQEGHKILSRKIQKFENQYRGRELPGFVNYRTFETI 457
Query: 505 VHQYIQQLVEPALSMLQKAMEIIQQAFINVAKKHFGEFFNLNQTVQSTIEDIKVKHTAKA 564
V Q I+ L EPA+ ML ++++ AF +V+ K+F EFFNL++T +S IEDI+ + +
Sbjct: 458 VKQQIKALEEPAVDMLHTVTDMVRLAFTDVSIKNFEEFFNLHRTAKSKIEDIRAEQEREG 517
Query: 565 ENMIQLQFRMEQMVFCQDQIYSVVLKKVRE-EIFNPLGTPSQNMKLNSHFPSNESSVSSF 623
E +I+L F+MEQ+V+CQDQ+Y L+KVRE E+ S + F S+ ++ SS
Sbjct: 518 EKLIRLHFQMEQIVYCQDQVYRGALQKVREKELEEEKKKKSWDF---GAFQSSSATDSSM 574
Query: 624 TEIGIHLNAYFLETSKRLANQIPFIIQYFMLRENGDSLQKAMMQILQEKNRYSWLLQEQS 683
EI HL AY E SKR+++ IP IIQ+FML+ G LQKAM+Q+LQ+K+ YSWLL+E+S
Sbjct: 575 EEIFQHLMAYHQEASKRISSHIPLIIQFFMLQTYGQQLQKAMLQLLQDKDTYSWLLKERS 634
Query: 684 ETATKRRILKERIYRLTQARHALCQF 709
+T+ KR+ LKER+ RLTQAR L QF
Sbjct: 635 DTSDKRKFLKERLARLTQARRRLAQF 660
>gi|222136617 myxovirus resistance protein 1 [Homo sapiens]
Length = 662
Score = 771 bits (1992), Expect = 0.0
Identities = 399/626 (63%), Positives = 495/626 (79%), Gaps = 5/626 (0%)
Query: 86 ENNLYSQYEQKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPR 145
ENNL SQYE+KVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPR
Sbjct: 38 ENNLCSQYEEKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPR 97
Query: 146 GSGIVTRCPLVLKLKKQPCE-AWAGRISYRNTELELQDPGQVEKEIHKAQNVMAGNGRGI 204
GSGIVTRCPLVLKLKK E W G++SY++ E+E+ D +VEKEI+KAQN +AG G GI
Sbjct: 98 GSGIVTRCPLVLKLKKLVNEDKWRGKVSYQDYEIEISDASEVEKEINKAQNAIAGEGMGI 157
Query: 205 SHELISLEITSPEVPDLTIIDLPGITRVAVDNQPRDIGLQIKALIKKYIQRQQTINLVVV 264
SHELI+LEI+S +VPDLT+IDLPGITRVAV NQP DIG +IK LIKKYIQRQ+TI+LVVV
Sbjct: 158 SHELITLEISSRDVPDLTLIDLPGITRVAVGNQPADIGYKIKTLIKKYIQRQETISLVVV 217
Query: 265 PCNVDIATTEALSMAHEVDPEGDRTIGILTKPDLMDRGTEKSVMNVVRNLTYPLKKGYMI 324
P NVDIATTEALSMA EVDPEGDRTIGILTKPDL+D+GTE V++VVRNL + LKKGYMI
Sbjct: 218 PSNVDIATTEALSMAQEVDPEGDRTIGILTKPDLVDKGTEDKVVDVVRNLVFHLKKGYMI 277
Query: 325 VKCRGQQEITNRLSLAEATKKEITFFQTHPYFRVLLEEGSATVPRLAERLTTELIMHIQK 384
VKCRGQQEI ++LSL+EA ++E FF+ HPYFR LLEEG ATVP LAE+LT+ELI HI K
Sbjct: 278 VKCRGQQEIQDQLSLSEALQREKIFFENHPYFRDLLEEGKATVPCLAEKLTSELITHICK 337
Query: 385 SLPLLEGQIRESHQKATEELRRCGADIPSQEADKMFFLIEKIKMFNQDIEKLVEGEEVVR 444
SLPLLE QI+E+HQ+ TEEL++ G DIP E +KMFFLI+K+ FNQDI L++GEE V
Sbjct: 338 SLPLLENQIKETHQRITEELQKYGVDIPEDENEKMFFLIDKVNAFNQDITALMQGEETVG 397
Query: 445 ENETRLYNKIREDFKNWVGILATNTQKVKNIIHEEVEKYEKQYRGKELLGFVNYKTFEII 504
E + RL+ ++R +F W I+ N Q+ I+ +++K+E QYRG+EL GFVNY+TFE I
Sbjct: 398 EEDIRLFTRLRHEFHKWSTIIENNFQEGHKILSRKIQKFENQYRGRELPGFVNYRTFETI 457
Query: 505 VHQYIQQLVEPALSMLQKAMEIIQQAFINVAKKHFGEFFNLNQTVQSTIEDIKVKHTAKA 564
V Q I+ L EPA+ ML ++++ AF +V+ K+F EFFNL++T +S IEDI+ + +
Sbjct: 458 VKQQIKALEEPAVDMLHTVTDMVRLAFTDVSIKNFEEFFNLHRTAKSKIEDIRAEQEREG 517
Query: 565 ENMIQLQFRMEQMVFCQDQIYSVVLKKVRE-EIFNPLGTPSQNMKLNSHFPSNESSVSSF 623
E +I+L F+MEQ+V+CQDQ+Y L+KVRE E+ S + F S+ ++ SS
Sbjct: 518 EKLIRLHFQMEQIVYCQDQVYRGALQKVREKELEEEKKKKSWDF---GAFQSSSATDSSM 574
Query: 624 TEIGIHLNAYFLETSKRLANQIPFIIQYFMLRENGDSLQKAMMQILQEKNRYSWLLQEQS 683
EI HL AY E SKR+++ IP IIQ+FML+ G LQKAM+Q+LQ+K+ YSWLL+E+S
Sbjct: 575 EEIFQHLMAYHQEASKRISSHIPLIIQFFMLQTYGQQLQKAMLQLLQDKDTYSWLLKERS 634
Query: 684 ETATKRRILKERIYRLTQARHALCQF 709
+T+ KR+ LKER+ RLTQAR L QF
Sbjct: 635 DTSDKRKFLKERLARLTQARRRLAQF 660
>gi|56549121 dynamin 2 isoform 1 [Homo sapiens]
Length = 870
Score = 224 bits (570), Expect = 3e-58
Identities = 157/440 (35%), Positives = 238/440 (54%), Gaps = 19/440 (4%)
Query: 103 LIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVA-LPRGSGIVTRCPLVLKLKK 161
L D+ ++G L LP IAV+G QS+GKSSVLE G LPRGSGIVTR PL+L+L
Sbjct: 16 LQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIF 75
Query: 162 QPCEAWAGRISYRNTELELQDPGQVEKEIHKAQNVMAGNGRGISHELISLEITSPEVPDL 221
E A + ++ + D +V +EI + + G +GIS I+L + SP V +L
Sbjct: 76 SKTEH-AEFLHCKSKKFT--DFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNL 132
Query: 222 TIIDLPGITRVAVDNQPRDIGLQIKALIKKYIQRQQTINLVVVPCNVDIATTEALSMAHE 281
T+IDLPGIT+V V +QP DI QIK +I ++I R+ ++ L V P N+D+A ++AL +A E
Sbjct: 133 TLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMDLANSDALKLAKE 192
Query: 282 VDPEGDRTIGILTKPDLMDRGTEKSVMNVVRNLTYPLKKGYMIVKCRGQQEITNRLSLAE 341
VDP+G RTIG++TK DLMD GT+ +V+ N PL++GY+ V R Q++I + +
Sbjct: 193 VDPQGLRTIGVITKLDLMDEGTD--ARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRA 250
Query: 342 ATKKEITFFQTHPYFRVLLEEGSATVPRLAERLTTELIMHIQKSLPLLEGQIRE---SHQ 398
A E FF +HP +R + + P L + L +L HI++SLP L +++ S +
Sbjct: 251 ALAAERKFFLSHPAYRHMADR--MGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLE 308
Query: 399 KATEELRRCGADIPSQEADKMFFLIEKIKMFNQDIEKLVEGE-EVVRENETRLYNKIRED 457
K EE + D P++ K L++ ++ F D EK +EG + V E +I
Sbjct: 309 KEVEEYKNFRPDDPTR---KTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGARINRI 365
Query: 458 FKNWVGILATNTQKVKNIIHEEVEKYEKQYRGKELLGFVNYKTFEIIVHQYIQQLVEPAL 517
F + + + E+ K G F FE IV + + +L EP L
Sbjct: 366 FHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDLAFEAIVKKQVVKLKEPCL 425
Query: 518 SMLQKAMEIIQQAFINVAKK 537
K ++++ Q IN ++
Sbjct: 426 ----KCVDLVIQELINTVRQ 441
>gi|56549119 dynamin 2 isoform 3 [Homo sapiens]
Length = 866
Score = 224 bits (570), Expect = 3e-58
Identities = 157/440 (35%), Positives = 238/440 (54%), Gaps = 19/440 (4%)
Query: 103 LIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVA-LPRGSGIVTRCPLVLKLKK 161
L D+ ++G L LP IAV+G QS+GKSSVLE G LPRGSGIVTR PL+L+L
Sbjct: 16 LQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIF 75
Query: 162 QPCEAWAGRISYRNTELELQDPGQVEKEIHKAQNVMAGNGRGISHELISLEITSPEVPDL 221
E A + ++ + D +V +EI + + G +GIS I+L + SP V +L
Sbjct: 76 SKTEH-AEFLHCKSKKFT--DFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNL 132
Query: 222 TIIDLPGITRVAVDNQPRDIGLQIKALIKKYIQRQQTINLVVVPCNVDIATTEALSMAHE 281
T+IDLPGIT+V V +QP DI QIK +I ++I R+ ++ L V P N+D+A ++AL +A E
Sbjct: 133 TLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMDLANSDALKLAKE 192
Query: 282 VDPEGDRTIGILTKPDLMDRGTEKSVMNVVRNLTYPLKKGYMIVKCRGQQEITNRLSLAE 341
VDP+G RTIG++TK DLMD GT+ +V+ N PL++GY+ V R Q++I + +
Sbjct: 193 VDPQGLRTIGVITKLDLMDEGTD--ARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRA 250
Query: 342 ATKKEITFFQTHPYFRVLLEEGSATVPRLAERLTTELIMHIQKSLPLLEGQIRE---SHQ 398
A E FF +HP +R + + P L + L +L HI++SLP L +++ S +
Sbjct: 251 ALAAERKFFLSHPAYRHMADR--MGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLE 308
Query: 399 KATEELRRCGADIPSQEADKMFFLIEKIKMFNQDIEKLVEGE-EVVRENETRLYNKIRED 457
K EE + D P++ K L++ ++ F D EK +EG + V E +I
Sbjct: 309 KEVEEYKNFRPDDPTR---KTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGARINRI 365
Query: 458 FKNWVGILATNTQKVKNIIHEEVEKYEKQYRGKELLGFVNYKTFEIIVHQYIQQLVEPAL 517
F + + + E+ K G F FE IV + + +L EP L
Sbjct: 366 FHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDLAFEAIVKKQVVKLKEPCL 425
Query: 518 SMLQKAMEIIQQAFINVAKK 537
K ++++ Q IN ++
Sbjct: 426 ----KCVDLVIQELINTVRQ 441
>gi|56549125 dynamin 2 isoform 4 [Homo sapiens]
Length = 866
Score = 223 bits (568), Expect = 5e-58
Identities = 158/440 (35%), Positives = 237/440 (53%), Gaps = 19/440 (4%)
Query: 103 LIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVA-LPRGSGIVTRCPLVLKLKK 161
L D+ ++G L LP IAV+G QS+GKSSVLE G LPRGSGIVTR PL+L+L
Sbjct: 16 LQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIF 75
Query: 162 QPCEAWAGRISYRNTELELQDPGQVEKEIHKAQNVMAGNGRGISHELISLEITSPEVPDL 221
E A + ++ + D +V +EI + + G +GIS I+L + SP V +L
Sbjct: 76 SKTEH-AEFLHCKSKKFT--DFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNL 132
Query: 222 TIIDLPGITRVAVDNQPRDIGLQIKALIKKYIQRQQTINLVVVPCNVDIATTEALSMAHE 281
T+IDLPGIT+V V +QP DI QIK +I ++I R+ ++ L V P N+D+A ++AL +A E
Sbjct: 133 TLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMDLANSDALKLAKE 192
Query: 282 VDPEGDRTIGILTKPDLMDRGTEKSVMNVVRNLTYPLKKGYMIVKCRGQQEITNRLSLAE 341
VDP+G RTIG++TK DLMD GT+ +V+ N PL++GY+ V R Q++I + +
Sbjct: 193 VDPQGLRTIGVITKLDLMDEGTD--ARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRA 250
Query: 342 ATKKEITFFQTHPYFRVLLEEGSATVPRLAERLTTELIMHIQKSLPLLEGQIRE---SHQ 398
A E FF +HP +R + + P L + L +L HI++SLP L +++ S +
Sbjct: 251 ALAAERKFFLSHPAYRHMADR--MGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLE 308
Query: 399 KATEELRRCGADIPSQEADKMFFLIEKIKMFNQDIEKLVEGE-EVVRENETRLYNKIRED 457
K EE + D P++ K L++ ++ F D EK +EG + V E +I
Sbjct: 309 KEVEEYKNFRPDDPTR---KTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGARINRI 365
Query: 458 FKNWVGILATNTQKVKNIIHEEVEKYEKQYRGKELLGFVNYKTFEIIVHQYIQQLVEPAL 517
F + + + E+ K G F FE IV + I +L EP+L
Sbjct: 366 FHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDMAFEAIVKKQIVKLKEPSL 425
Query: 518 SMLQKAMEIIQQAFINVAKK 537
K ++++ V KK
Sbjct: 426 ----KCVDLVVSELATVIKK 441
>gi|56549123 dynamin 2 isoform 2 [Homo sapiens]
Length = 870
Score = 223 bits (568), Expect = 5e-58
Identities = 158/440 (35%), Positives = 237/440 (53%), Gaps = 19/440 (4%)
Query: 103 LIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVA-LPRGSGIVTRCPLVLKLKK 161
L D+ ++G L LP IAV+G QS+GKSSVLE G LPRGSGIVTR PL+L+L
Sbjct: 16 LQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIF 75
Query: 162 QPCEAWAGRISYRNTELELQDPGQVEKEIHKAQNVMAGNGRGISHELISLEITSPEVPDL 221
E A + ++ + D +V +EI + + G +GIS I+L + SP V +L
Sbjct: 76 SKTEH-AEFLHCKSKKFT--DFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNL 132
Query: 222 TIIDLPGITRVAVDNQPRDIGLQIKALIKKYIQRQQTINLVVVPCNVDIATTEALSMAHE 281
T+IDLPGIT+V V +QP DI QIK +I ++I R+ ++ L V P N+D+A ++AL +A E
Sbjct: 133 TLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMDLANSDALKLAKE 192
Query: 282 VDPEGDRTIGILTKPDLMDRGTEKSVMNVVRNLTYPLKKGYMIVKCRGQQEITNRLSLAE 341
VDP+G RTIG++TK DLMD GT+ +V+ N PL++GY+ V R Q++I + +
Sbjct: 193 VDPQGLRTIGVITKLDLMDEGTD--ARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRA 250
Query: 342 ATKKEITFFQTHPYFRVLLEEGSATVPRLAERLTTELIMHIQKSLPLLEGQIRE---SHQ 398
A E FF +HP +R + + P L + L +L HI++SLP L +++ S +
Sbjct: 251 ALAAERKFFLSHPAYRHMADR--MGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLE 308
Query: 399 KATEELRRCGADIPSQEADKMFFLIEKIKMFNQDIEKLVEGE-EVVRENETRLYNKIRED 457
K EE + D P++ K L++ ++ F D EK +EG + V E +I
Sbjct: 309 KEVEEYKNFRPDDPTR---KTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGARINRI 365
Query: 458 FKNWVGILATNTQKVKNIIHEEVEKYEKQYRGKELLGFVNYKTFEIIVHQYIQQLVEPAL 517
F + + + E+ K G F FE IV + I +L EP+L
Sbjct: 366 FHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDMAFEAIVKKQIVKLKEPSL 425
Query: 518 SMLQKAMEIIQQAFINVAKK 537
K ++++ V KK
Sbjct: 426 ----KCVDLVVSELATVIKK 441
>gi|42544243 dynamin 3 isoform a [Homo sapiens]
Length = 863
Score = 219 bits (558), Expect = 7e-57
Identities = 162/465 (34%), Positives = 237/465 (50%), Gaps = 14/465 (3%)
Query: 103 LIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVA-LPRGSGIVTRCPLVLKLKK 161
L D+ ALG L LP IAV+G QS+GKSSVLE G LPRGSGIVTR PLVL+L
Sbjct: 16 LQDAFSALGQSCLLELPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLVLQLVT 75
Query: 162 QPCEAWAGRISYRNTELELQDPGQVEKEIHKAQNVMAGNGRGISHELISLEITSPEVPDL 221
E +A + + + D +V EI + + G +GIS I+L + SP V +L
Sbjct: 76 SKAE-YAEFLHCKGKKFT--DFDEVRLEIEAETDRVTGMNKGISSIPINLRVYSPHVLNL 132
Query: 222 TIIDLPGITRVAVDNQPRDIGLQIKALIKKYIQRQQTINLVVVPCNVDIATTEALSMAHE 281
T+IDLPGIT+V V +QP DI QI+ +I ++I R+ + L V P N D+A ++AL +A E
Sbjct: 133 TLIDLPGITKVPVGDQPPDIEYQIREMIMQFITRENCLILAVTPANTDLANSDALKLAKE 192
Query: 282 VDPEGDRTIGILTKPDLMDRGTEKSVMNVVRNLTYPLKKGYMIVKCRGQQEITNRLSLAE 341
VDP+G RTIG++TK DLMD GT+ +V+ N PL++GY+ V R Q++I + +
Sbjct: 193 VDPQGLRTIGVITKLDLMDEGTD--ARDVLENKLLPLRRGYVGVVNRSQKDIDGKKDIKA 250
Query: 342 ATKKEITFFQTHPYFRVLLEEGSATVPRLAERLTTELIMHIQKSLPLLEGQIRESHQKAT 401
A E FF +HP +R + + P L + L +L HI+ +LP +++
Sbjct: 251 AMLAERKFFLSHPAYRHIADR--MGTPHLQKVLNQQLTNHIRDTLPNFRNKLQGQLLSIE 308
Query: 402 EELRRCGADIPSQEADKMFFLIEKIKMFNQDIEKLVEGE-EVVRENETRLYNKIREDFKN 460
E+ P K L++ ++ F D EK +EG + V E KI F
Sbjct: 309 HEVEAYKNFKPEDPTRKTKALLQMVQQFAVDFEKRIEGSGDQVDTLELSGGAKINRIFHE 368
Query: 461 WVGILATNTQKVKNIIHEEVEKYEKQYRGKELLGFVNYKTFEIIVHQYIQQLVEPALSML 520
+ + + E+ K G F FE IV + I +L P+L
Sbjct: 369 RFPFEIVKMEFNEKELRREISYAIKNIHGIRTGLFTPDMAFEAIVKKQIVKLKGPSL--- 425
Query: 521 QKAMEIIQQAFINVAKKHFGEFFNLNQTVQSTIEDIKVKHTAKAE 565
K+++++ Q IN KK + N + + T E I H + E
Sbjct: 426 -KSVDLVIQELINTVKKCTKKLANFPRLCEET-ERIVANHIRERE 468
>gi|209915561 dynamin 3 isoform b [Homo sapiens]
Length = 859
Score = 219 bits (558), Expect = 7e-57
Identities = 162/465 (34%), Positives = 237/465 (50%), Gaps = 14/465 (3%)
Query: 103 LIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVA-LPRGSGIVTRCPLVLKLKK 161
L D+ ALG L LP IAV+G QS+GKSSVLE G LPRGSGIVTR PLVL+L
Sbjct: 16 LQDAFSALGQSCLLELPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLVLQLVT 75
Query: 162 QPCEAWAGRISYRNTELELQDPGQVEKEIHKAQNVMAGNGRGISHELISLEITSPEVPDL 221
E +A + + + D +V EI + + G +GIS I+L + SP V +L
Sbjct: 76 SKAE-YAEFLHCKGKKFT--DFDEVRLEIEAETDRVTGMNKGISSIPINLRVYSPHVLNL 132
Query: 222 TIIDLPGITRVAVDNQPRDIGLQIKALIKKYIQRQQTINLVVVPCNVDIATTEALSMAHE 281
T+IDLPGIT+V V +QP DI QI+ +I ++I R+ + L V P N D+A ++AL +A E
Sbjct: 133 TLIDLPGITKVPVGDQPPDIEYQIREMIMQFITRENCLILAVTPANTDLANSDALKLAKE 192
Query: 282 VDPEGDRTIGILTKPDLMDRGTEKSVMNVVRNLTYPLKKGYMIVKCRGQQEITNRLSLAE 341
VDP+G RTIG++TK DLMD GT+ +V+ N PL++GY+ V R Q++I + +
Sbjct: 193 VDPQGLRTIGVITKLDLMDEGTD--ARDVLENKLLPLRRGYVGVVNRSQKDIDGKKDIKA 250
Query: 342 ATKKEITFFQTHPYFRVLLEEGSATVPRLAERLTTELIMHIQKSLPLLEGQIRESHQKAT 401
A E FF +HP +R + + P L + L +L HI+ +LP +++
Sbjct: 251 AMLAERKFFLSHPAYRHIADR--MGTPHLQKVLNQQLTNHIRDTLPNFRNKLQGQLLSIE 308
Query: 402 EELRRCGADIPSQEADKMFFLIEKIKMFNQDIEKLVEGE-EVVRENETRLYNKIREDFKN 460
E+ P K L++ ++ F D EK +EG + V E KI F
Sbjct: 309 HEVEAYKNFKPEDPTRKTKALLQMVQQFAVDFEKRIEGSGDQVDTLELSGGAKINRIFHE 368
Query: 461 WVGILATNTQKVKNIIHEEVEKYEKQYRGKELLGFVNYKTFEIIVHQYIQQLVEPALSML 520
+ + + E+ K G F FE IV + I +L P+L
Sbjct: 369 RFPFEIVKMEFNEKELRREISYAIKNIHGIRTGLFTPDMAFEAIVKKQIVKLKGPSL--- 425
Query: 521 QKAMEIIQQAFINVAKKHFGEFFNLNQTVQSTIEDIKVKHTAKAE 565
K+++++ Q IN KK + N + + T E I H + E
Sbjct: 426 -KSVDLVIQELINTVKKCTKKLANFPRLCEET-ERIVANHIRERE 468
>gi|56549117 dynamin 1 isoform 2 [Homo sapiens]
Length = 851
Score = 215 bits (547), Expect = 1e-55
Identities = 151/440 (34%), Positives = 234/440 (53%), Gaps = 19/440 (4%)
Query: 103 LIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVA-LPRGSGIVTRCPLVLKLKK 161
L D+ A+G DL LP IAV+G QS+GKSSVLE G LPRGSGIVTR PLVL+L
Sbjct: 16 LQDAFSAIGQNADLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLVLQLVN 75
Query: 162 QPCEAWAGRISYRNTELELQDPGQVEKEIHKAQNVMAGNGRGISHELISLEITSPEVPDL 221
E +A + + + D +V EI + + G +GIS I+L + SP V +L
Sbjct: 76 ATTE-YAEFLHCKGKKFT--DFEEVRLEIEAETDRVTGTNKGISPVPINLRVYSPHVLNL 132
Query: 222 TIIDLPGITRVAVDNQPRDIGLQIKALIKKYIQRQQTINLVVVPCNVDIATTEALSMAHE 281
T++DLPG+T+V V +QP DI QI+ ++ +++ ++ + L V P N D+A ++AL +A E
Sbjct: 133 TLVDLPGMTKVPVGDQPPDIEFQIRDMLMQFVTKENCLILAVSPANSDLANSDALKVAKE 192
Query: 282 VDPEGDRTIGILTKPDLMDRGTEKSVMNVVRNLTYPLKKGYMIVKCRGQQEITNRLSLAE 341
VDP+G RTIG++TK DLMD GT+ +V+ N PL++GY+ V R Q++I + +
Sbjct: 193 VDPQGQRTIGVITKLDLMDEGTD--ARDVLENKLLPLRRGYIGVVNRSQKDIDGKKDITA 250
Query: 342 ATKKEITFFQTHPYFRVLLEEGSATVPRLAERLTTELIMHIQKSLPLLEGQIRE---SHQ 398
A E FF +HP +R L + P L + L +L HI+ +LP L +++ S +
Sbjct: 251 ALAAERKFFLSHPSYRHLADR--MGTPYLQKVLNQQLTNHIRDTLPGLRNKLQSQLLSIE 308
Query: 399 KATEELRRCGADIPSQEADKMFFLIEKIKMFNQDIEKLVEGE-EVVRENETRLYNKIRED 457
K EE + D P A K L++ ++ F D EK +EG + + E +I
Sbjct: 309 KEVEEYKNFRPDDP---ARKTKALLQMVQQFAVDFEKRIEGSGDQIDTYELSGGARINRI 365
Query: 458 FKNWVGILATNTQKVKNIIHEEVEKYEKQYRGKELLGFVNYKTFEIIVHQYIQQLVEPAL 517
F + + + E+ K G F FE IV + ++++ EP L
Sbjct: 366 FHERFPFELVKMEFDEKELRREISYAIKNIHGIRTGLFTPDMAFETIVKKQVKKIREPCL 425
Query: 518 SMLQKAMEIIQQAFINVAKK 537
K ++++ I+ ++
Sbjct: 426 ----KCVDMVISELISTVRQ 441
>gi|59853099 dynamin 1 isoform 1 [Homo sapiens]
Length = 864
Score = 215 bits (547), Expect = 1e-55
Identities = 151/440 (34%), Positives = 234/440 (53%), Gaps = 19/440 (4%)
Query: 103 LIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVA-LPRGSGIVTRCPLVLKLKK 161
L D+ A+G DL LP IAV+G QS+GKSSVLE G LPRGSGIVTR PLVL+L
Sbjct: 16 LQDAFSAIGQNADLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLVLQLVN 75
Query: 162 QPCEAWAGRISYRNTELELQDPGQVEKEIHKAQNVMAGNGRGISHELISLEITSPEVPDL 221
E +A + + + D +V EI + + G +GIS I+L + SP V +L
Sbjct: 76 ATTE-YAEFLHCKGKKFT--DFEEVRLEIEAETDRVTGTNKGISPVPINLRVYSPHVLNL 132
Query: 222 TIIDLPGITRVAVDNQPRDIGLQIKALIKKYIQRQQTINLVVVPCNVDIATTEALSMAHE 281
T++DLPG+T+V V +QP DI QI+ ++ +++ ++ + L V P N D+A ++AL +A E
Sbjct: 133 TLVDLPGMTKVPVGDQPPDIEFQIRDMLMQFVTKENCLILAVSPANSDLANSDALKVAKE 192
Query: 282 VDPEGDRTIGILTKPDLMDRGTEKSVMNVVRNLTYPLKKGYMIVKCRGQQEITNRLSLAE 341
VDP+G RTIG++TK DLMD GT+ +V+ N PL++GY+ V R Q++I + +
Sbjct: 193 VDPQGQRTIGVITKLDLMDEGTD--ARDVLENKLLPLRRGYIGVVNRSQKDIDGKKDITA 250
Query: 342 ATKKEITFFQTHPYFRVLLEEGSATVPRLAERLTTELIMHIQKSLPLLEGQIRE---SHQ 398
A E FF +HP +R L + P L + L +L HI+ +LP L +++ S +
Sbjct: 251 ALAAERKFFLSHPSYRHLADR--MGTPYLQKVLNQQLTNHIRDTLPGLRNKLQSQLLSIE 308
Query: 399 KATEELRRCGADIPSQEADKMFFLIEKIKMFNQDIEKLVEGE-EVVRENETRLYNKIRED 457
K EE + D P A K L++ ++ F D EK +EG + + E +I
Sbjct: 309 KEVEEYKNFRPDDP---ARKTKALLQMVQQFAVDFEKRIEGSGDQIDTYELSGGARINRI 365
Query: 458 FKNWVGILATNTQKVKNIIHEEVEKYEKQYRGKELLGFVNYKTFEIIVHQYIQQLVEPAL 517
F + + + E+ K G F FE IV + ++++ EP L
Sbjct: 366 FHERFPFELVKMEFDEKELRREISYAIKNIHGIRTGLFTPDMAFETIVKKQVKKIREPCL 425
Query: 518 SMLQKAMEIIQQAFINVAKK 537
K ++++ I+ ++
Sbjct: 426 ----KCVDMVISELISTVRQ 441
>gi|171460914 dynamin 1-like isoform 1 [Homo sapiens]
Length = 736
Score = 196 bits (497), Expect = 8e-50
Identities = 151/473 (31%), Positives = 241/473 (50%), Gaps = 32/473 (6%)
Query: 116 LALPAIAVIGDQSSGKSSVLEALSGV-ALPRGSGIVTRCPLVLKL-------KKQP---- 163
+ LP I V+G QSSGKSSVLE+L G LPRG+GIVTR PL+L+L K++
Sbjct: 23 IQLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTGIVTRRPLILQLVHVSQEDKRKTTGEE 82
Query: 164 ----CEAWAGRISYRNTELELQDPGQVEKEIHKAQNVMAGNGRGISHELISLEITSPEVP 219
E W G+ + +L D ++ +EI ++GN +G+S E I L+I SP V
Sbjct: 83 NGVEAEEW-GKFLHTKNKL-YTDFDEIRQEIENETERISGNNKGVSPEPIHLKIFSPNVV 140
Query: 220 DLTIIDLPGITRVAVDNQPRDIGLQIKALIKKYIQRQQTINLVVVPCNVDIATTEALSMA 279
+LT++DLPG+T+V V +QP+DI LQI+ LI ++I +I L V N D+AT+EAL ++
Sbjct: 141 NLTLVDLPGMTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKIS 200
Query: 280 HEVDPEGDRTIGILTKPDLMDRGTEKSVMNVVRNLTYPLKKGYMIVKCRGQQEITNRLSL 339
EVDP+G RT+ ++TK DLMD GT+ M+V+ P+K G + V R Q +I N+ S+
Sbjct: 201 REVDPDGRRTLAVITKLDLMDAGTD--AMDVLMGRVIPVKLGIIGVVNRSQLDINNKKSV 258
Query: 340 AEATKKEITFFQTHPYFRVLLEEGSATVPRLAERLTTELIMHIQKSLPLLEGQIRESHQK 399
++ + E F Q Y + G+ + R RL L+ HI+ LP L+ +I +
Sbjct: 259 TDSIRDEYAFLQ-KKYPSLANRNGTKYLARTLNRL---LMHHIRDCLPELKTRINVLAAQ 314
Query: 400 ATEELRRCGADIPSQEADKMFFLIEKIKMFNQDIEKLVEG-EEVVRENETRLYNKIREDF 458
L G + DK L++ I F + +EG + + +E +I F
Sbjct: 315 YQSLLNSYGEPVD----DKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIF 370
Query: 459 KNWVGILATNTQKVKNIIHEEVEKYEKQYRGKELLGFVNYKTFEIIVHQYIQQLVEPAL- 517
G + + + ++ + G FV +FE++V + I++L EP+L
Sbjct: 371 HETFGRTLESVDPLGGLNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLR 430
Query: 518 --SMLQKAMEIIQQAFINVAKKHFGEFFNLNQTVQSTIEDIKVKHTAKAENMI 568
++ + M+ I Q N + + F L+ + + + K M+
Sbjct: 431 CVELVHEEMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMV 483
Score = 34.3 bits (77), Expect = 0.41
Identities = 19/86 (22%), Positives = 41/86 (47%), Gaps = 2/86 (2%)
Query: 630 LNAYFLETSKRLANQIPFIIQYFMLRENGDSLQKAMMQILQEKNRYSWLLQEQSETATKR 689
+ +YFL K + + +P + +F++ D+LQ ++ L + + LL E + A +R
Sbjct: 651 IKSYFLIVRKNIQDSVPKAVMHFLVNHVKDTLQSELVGQLYKSSLLDDLLTESEDMAQRR 710
Query: 690 RILKERIYRLTQARHALCQFSSKEIH 715
+ + + L A + + +E H
Sbjct: 711 KEAADMLKALQGASQIIAEI--RETH 734
>gi|171460918 dynamin 1-like isoform 3 [Homo sapiens]
Length = 699
Score = 196 bits (497), Expect = 8e-50
Identities = 151/473 (31%), Positives = 241/473 (50%), Gaps = 32/473 (6%)
Query: 116 LALPAIAVIGDQSSGKSSVLEALSGV-ALPRGSGIVTRCPLVLKL-------KKQP---- 163
+ LP I V+G QSSGKSSVLE+L G LPRG+GIVTR PL+L+L K++
Sbjct: 23 IQLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTGIVTRRPLILQLVHVSQEDKRKTTGEE 82
Query: 164 ----CEAWAGRISYRNTELELQDPGQVEKEIHKAQNVMAGNGRGISHELISLEITSPEVP 219
E W G+ + +L D ++ +EI ++GN +G+S E I L+I SP V
Sbjct: 83 NGVEAEEW-GKFLHTKNKL-YTDFDEIRQEIENETERISGNNKGVSPEPIHLKIFSPNVV 140
Query: 220 DLTIIDLPGITRVAVDNQPRDIGLQIKALIKKYIQRQQTINLVVVPCNVDIATTEALSMA 279
+LT++DLPG+T+V V +QP+DI LQI+ LI ++I +I L V N D+AT+EAL ++
Sbjct: 141 NLTLVDLPGMTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKIS 200
Query: 280 HEVDPEGDRTIGILTKPDLMDRGTEKSVMNVVRNLTYPLKKGYMIVKCRGQQEITNRLSL 339
EVDP+G RT+ ++TK DLMD GT+ M+V+ P+K G + V R Q +I N+ S+
Sbjct: 201 REVDPDGRRTLAVITKLDLMDAGTD--AMDVLMGRVIPVKLGIIGVVNRSQLDINNKKSV 258
Query: 340 AEATKKEITFFQTHPYFRVLLEEGSATVPRLAERLTTELIMHIQKSLPLLEGQIRESHQK 399
++ + E F Q Y + G+ + R RL L+ HI+ LP L+ +I +
Sbjct: 259 TDSIRDEYAFLQ-KKYPSLANRNGTKYLARTLNRL---LMHHIRDCLPELKTRINVLAAQ 314
Query: 400 ATEELRRCGADIPSQEADKMFFLIEKIKMFNQDIEKLVEG-EEVVRENETRLYNKIREDF 458
L G + DK L++ I F + +EG + + +E +I F
Sbjct: 315 YQSLLNSYGEPVD----DKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIF 370
Query: 459 KNWVGILATNTQKVKNIIHEEVEKYEKQYRGKELLGFVNYKTFEIIVHQYIQQLVEPAL- 517
G + + + ++ + G FV +FE++V + I++L EP+L
Sbjct: 371 HETFGRTLESVDPLGGLNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLR 430
Query: 518 --SMLQKAMEIIQQAFINVAKKHFGEFFNLNQTVQSTIEDIKVKHTAKAENMI 568
++ + M+ I Q N + + F L+ + + + K M+
Sbjct: 431 CVELVHEEMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMV 483
Score = 34.3 bits (77), Expect = 0.41
Identities = 19/86 (22%), Positives = 41/86 (47%), Gaps = 2/86 (2%)
Query: 630 LNAYFLETSKRLANQIPFIIQYFMLRENGDSLQKAMMQILQEKNRYSWLLQEQSETATKR 689
+ +YFL K + + +P + +F++ D+LQ ++ L + + LL E + A +R
Sbjct: 614 IKSYFLIVRKNIQDSVPKAVMHFLVNHVKDTLQSELVGQLYKSSLLDDLLTESEDMAQRR 673
Query: 690 RILKERIYRLTQARHALCQFSSKEIH 715
+ + + L A + + +E H
Sbjct: 674 KEAADMLKALQGASQIIAEI--RETH 697
>gi|171460916 dynamin 1-like isoform 2 [Homo sapiens]
Length = 710
Score = 196 bits (497), Expect = 8e-50
Identities = 151/473 (31%), Positives = 241/473 (50%), Gaps = 32/473 (6%)
Query: 116 LALPAIAVIGDQSSGKSSVLEALSGV-ALPRGSGIVTRCPLVLKL-------KKQP---- 163
+ LP I V+G QSSGKSSVLE+L G LPRG+GIVTR PL+L+L K++
Sbjct: 23 IQLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTGIVTRRPLILQLVHVSQEDKRKTTGEE 82
Query: 164 ----CEAWAGRISYRNTELELQDPGQVEKEIHKAQNVMAGNGRGISHELISLEITSPEVP 219
E W G+ + +L D ++ +EI ++GN +G+S E I L+I SP V
Sbjct: 83 NGVEAEEW-GKFLHTKNKL-YTDFDEIRQEIENETERISGNNKGVSPEPIHLKIFSPNVV 140
Query: 220 DLTIIDLPGITRVAVDNQPRDIGLQIKALIKKYIQRQQTINLVVVPCNVDIATTEALSMA 279
+LT++DLPG+T+V V +QP+DI LQI+ LI ++I +I L V N D+AT+EAL ++
Sbjct: 141 NLTLVDLPGMTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKIS 200
Query: 280 HEVDPEGDRTIGILTKPDLMDRGTEKSVMNVVRNLTYPLKKGYMIVKCRGQQEITNRLSL 339
EVDP+G RT+ ++TK DLMD GT+ M+V+ P+K G + V R Q +I N+ S+
Sbjct: 201 REVDPDGRRTLAVITKLDLMDAGTD--AMDVLMGRVIPVKLGIIGVVNRSQLDINNKKSV 258
Query: 340 AEATKKEITFFQTHPYFRVLLEEGSATVPRLAERLTTELIMHIQKSLPLLEGQIRESHQK 399
++ + E F Q Y + G+ + R RL L+ HI+ LP L+ +I +
Sbjct: 259 TDSIRDEYAFLQ-KKYPSLANRNGTKYLARTLNRL---LMHHIRDCLPELKTRINVLAAQ 314
Query: 400 ATEELRRCGADIPSQEADKMFFLIEKIKMFNQDIEKLVEG-EEVVRENETRLYNKIREDF 458
L G + DK L++ I F + +EG + + +E +I F
Sbjct: 315 YQSLLNSYGEPVD----DKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIF 370
Query: 459 KNWVGILATNTQKVKNIIHEEVEKYEKQYRGKELLGFVNYKTFEIIVHQYIQQLVEPAL- 517
G + + + ++ + G FV +FE++V + I++L EP+L
Sbjct: 371 HETFGRTLESVDPLGGLNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLR 430
Query: 518 --SMLQKAMEIIQQAFINVAKKHFGEFFNLNQTVQSTIEDIKVKHTAKAENMI 568
++ + M+ I Q N + + F L+ + + + K M+
Sbjct: 431 CVELVHEEMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMV 483
Score = 34.3 bits (77), Expect = 0.41
Identities = 19/86 (22%), Positives = 41/86 (47%), Gaps = 2/86 (2%)
Query: 630 LNAYFLETSKRLANQIPFIIQYFMLRENGDSLQKAMMQILQEKNRYSWLLQEQSETATKR 689
+ +YFL K + + +P + +F++ D+LQ ++ L + + LL E + A +R
Sbjct: 625 IKSYFLIVRKNIQDSVPKAVMHFLVNHVKDTLQSELVGQLYKSSLLDDLLTESEDMAQRR 684
Query: 690 RILKERIYRLTQARHALCQFSSKEIH 715
+ + + L A + + +E H
Sbjct: 685 KEAADMLKALQGASQIIAEI--RETH 708
>gi|224831253 optic atrophy 1 isoform 8 [Homo sapiens]
Length = 1015
Score = 98.6 bits (244), Expect = 2e-20
Identities = 65/214 (30%), Positives = 107/214 (50%), Gaps = 6/214 (2%)
Query: 118 LPAIAVIGDQSSGKSSVLEALSGVAL-PRGSG-IVTRCPLVLKLKKQPCEAWAGRISYRN 175
LP + V+GDQS+GK+SVLE ++ + PRGSG ++TR P+ + L + P + S R
Sbjct: 343 LPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSRE 402
Query: 176 TEL-ELQDPGQVEKEIHKAQNVMAGNGRGISHELISLEITSPEVPDLTIIDLPGITRVAV 234
+L + +D + EI G +S E ISL + P + + ++DLPG+
Sbjct: 403 FDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVT 462
Query: 235 DNQPRDIGLQIKALIKKYIQRQQTINLVVVPCNVDIATTEALSMAHEVDPEGDRTIGILT 294
D I ++ K Y+Q I L + +VD + + ++DP G RTI +LT
Sbjct: 463 SGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLT 522
Query: 295 KPDLMDR--GTEKSVMNVVRNLTYPLKK-GYMIV 325
K DL ++ + + ++ +P+K GY V
Sbjct: 523 KVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAV 556
>gi|224831251 optic atrophy 1 isoform 7 [Homo sapiens]
Length = 997
Score = 98.6 bits (244), Expect = 2e-20
Identities = 65/214 (30%), Positives = 107/214 (50%), Gaps = 6/214 (2%)
Query: 118 LPAIAVIGDQSSGKSSVLEALSGVAL-PRGSG-IVTRCPLVLKLKKQPCEAWAGRISYRN 175
LP + V+GDQS+GK+SVLE ++ + PRGSG ++TR P+ + L + P + S R
Sbjct: 325 LPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSRE 384
Query: 176 TEL-ELQDPGQVEKEIHKAQNVMAGNGRGISHELISLEITSPEVPDLTIIDLPGITRVAV 234
+L + +D + EI G +S E ISL + P + + ++DLPG+
Sbjct: 385 FDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVT 444
Query: 235 DNQPRDIGLQIKALIKKYIQRQQTINLVVVPCNVDIATTEALSMAHEVDPEGDRTIGILT 294
D I ++ K Y+Q I L + +VD + + ++DP G RTI +LT
Sbjct: 445 SGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLT 504
Query: 295 KPDLMDR--GTEKSVMNVVRNLTYPLKK-GYMIV 325
K DL ++ + + ++ +P+K GY V
Sbjct: 505 KVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAV 538
>gi|18860841 optic atrophy 1 isoform 6 [Homo sapiens]
Length = 979
Score = 98.6 bits (244), Expect = 2e-20
Identities = 65/214 (30%), Positives = 107/214 (50%), Gaps = 6/214 (2%)
Query: 118 LPAIAVIGDQSSGKSSVLEALSGVAL-PRGSG-IVTRCPLVLKLKKQPCEAWAGRISYRN 175
LP + V+GDQS+GK+SVLE ++ + PRGSG ++TR P+ + L + P + S R
Sbjct: 307 LPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSRE 366
Query: 176 TEL-ELQDPGQVEKEIHKAQNVMAGNGRGISHELISLEITSPEVPDLTIIDLPGITRVAV 234
+L + +D + EI G +S E ISL + P + + ++DLPG+
Sbjct: 367 FDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVT 426
Query: 235 DNQPRDIGLQIKALIKKYIQRQQTINLVVVPCNVDIATTEALSMAHEVDPEGDRTIGILT 294
D I ++ K Y+Q I L + +VD + + ++DP G RTI +LT
Sbjct: 427 SGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLT 486
Query: 295 KPDLMDR--GTEKSVMNVVRNLTYPLKK-GYMIV 325
K DL ++ + + ++ +P+K GY V
Sbjct: 487 KVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAV 520
>gi|224831248 optic atrophy 1 isoform 5 [Homo sapiens]
Length = 978
Score = 98.6 bits (244), Expect = 2e-20
Identities = 65/214 (30%), Positives = 107/214 (50%), Gaps = 6/214 (2%)
Query: 118 LPAIAVIGDQSSGKSSVLEALSGVAL-PRGSG-IVTRCPLVLKLKKQPCEAWAGRISYRN 175
LP + V+GDQS+GK+SVLE ++ + PRGSG ++TR P+ + L + P + S R
Sbjct: 306 LPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSRE 365
Query: 176 TEL-ELQDPGQVEKEIHKAQNVMAGNGRGISHELISLEITSPEVPDLTIIDLPGITRVAV 234
+L + +D + EI G +S E ISL + P + + ++DLPG+
Sbjct: 366 FDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVT 425
Query: 235 DNQPRDIGLQIKALIKKYIQRQQTINLVVVPCNVDIATTEALSMAHEVDPEGDRTIGILT 294
D I ++ K Y+Q I L + +VD + + ++DP G RTI +LT
Sbjct: 426 SGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLT 485
Query: 295 KPDLMDR--GTEKSVMNVVRNLTYPLKK-GYMIV 325
K DL ++ + + ++ +P+K GY V
Sbjct: 486 KVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAV 519
>gi|18860835 optic atrophy 1 isoform 4 [Homo sapiens]
Length = 961
Score = 98.6 bits (244), Expect = 2e-20
Identities = 65/214 (30%), Positives = 107/214 (50%), Gaps = 6/214 (2%)
Query: 118 LPAIAVIGDQSSGKSSVLEALSGVAL-PRGSG-IVTRCPLVLKLKKQPCEAWAGRISYRN 175
LP + V+GDQS+GK+SVLE ++ + PRGSG ++TR P+ + L + P + S R
Sbjct: 289 LPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSRE 348
Query: 176 TEL-ELQDPGQVEKEIHKAQNVMAGNGRGISHELISLEITSPEVPDLTIIDLPGITRVAV 234
+L + +D + EI G +S E ISL + P + + ++DLPG+
Sbjct: 349 FDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVT 408
Query: 235 DNQPRDIGLQIKALIKKYIQRQQTINLVVVPCNVDIATTEALSMAHEVDPEGDRTIGILT 294
D I ++ K Y+Q I L + +VD + + ++DP G RTI +LT
Sbjct: 409 SGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLT 468
Query: 295 KPDLMDR--GTEKSVMNVVRNLTYPLKK-GYMIV 325
K DL ++ + + ++ +P+K GY V
Sbjct: 469 KVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAV 502
>gi|18860833 optic atrophy 1 isoform 3 [Homo sapiens]
Length = 942
Score = 98.6 bits (244), Expect = 2e-20
Identities = 65/214 (30%), Positives = 107/214 (50%), Gaps = 6/214 (2%)
Query: 118 LPAIAVIGDQSSGKSSVLEALSGVAL-PRGSG-IVTRCPLVLKLKKQPCEAWAGRISYRN 175
LP + V+GDQS+GK+SVLE ++ + PRGSG ++TR P+ + L + P + S R
Sbjct: 270 LPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSRE 329
Query: 176 TEL-ELQDPGQVEKEIHKAQNVMAGNGRGISHELISLEITSPEVPDLTIIDLPGITRVAV 234
+L + +D + EI G +S E ISL + P + + ++DLPG+
Sbjct: 330 FDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVT 389
Query: 235 DNQPRDIGLQIKALIKKYIQRQQTINLVVVPCNVDIATTEALSMAHEVDPEGDRTIGILT 294
D I ++ K Y+Q I L + +VD + + ++DP G RTI +LT
Sbjct: 390 SGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLT 449
Query: 295 KPDLMDR--GTEKSVMNVVRNLTYPLKK-GYMIV 325
K DL ++ + + ++ +P+K GY V
Sbjct: 450 KVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAV 483
>gi|18860831 optic atrophy 1 isoform 2 [Homo sapiens]
Length = 924
Score = 98.6 bits (244), Expect = 2e-20
Identities = 65/214 (30%), Positives = 107/214 (50%), Gaps = 6/214 (2%)
Query: 118 LPAIAVIGDQSSGKSSVLEALSGVAL-PRGSG-IVTRCPLVLKLKKQPCEAWAGRISYRN 175
LP + V+GDQS+GK+SVLE ++ + PRGSG ++TR P+ + L + P + S R
Sbjct: 252 LPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSRE 311
Query: 176 TEL-ELQDPGQVEKEIHKAQNVMAGNGRGISHELISLEITSPEVPDLTIIDLPGITRVAV 234
+L + +D + EI G +S E ISL + P + + ++DLPG+
Sbjct: 312 FDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVT 371
Query: 235 DNQPRDIGLQIKALIKKYIQRQQTINLVVVPCNVDIATTEALSMAHEVDPEGDRTIGILT 294
D I ++ K Y+Q I L + +VD + + ++DP G RTI +LT
Sbjct: 372 SGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLT 431
Query: 295 KPDLMDR--GTEKSVMNVVRNLTYPLKK-GYMIV 325
K DL ++ + + ++ +P+K GY V
Sbjct: 432 KVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAV 465
>gi|224831243 optic atrophy 1 isoform 1 [Homo sapiens]
Length = 960
Score = 98.6 bits (244), Expect = 2e-20
Identities = 65/214 (30%), Positives = 107/214 (50%), Gaps = 6/214 (2%)
Query: 118 LPAIAVIGDQSSGKSSVLEALSGVAL-PRGSG-IVTRCPLVLKLKKQPCEAWAGRISYRN 175
LP + V+GDQS+GK+SVLE ++ + PRGSG ++TR P+ + L + P + S R
Sbjct: 288 LPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSRE 347
Query: 176 TEL-ELQDPGQVEKEIHKAQNVMAGNGRGISHELISLEITSPEVPDLTIIDLPGITRVAV 234
+L + +D + EI G +S E ISL + P + + ++DLPG+
Sbjct: 348 FDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVT 407
Query: 235 DNQPRDIGLQIKALIKKYIQRQQTINLVVVPCNVDIATTEALSMAHEVDPEGDRTIGILT 294
D I ++ K Y+Q I L + +VD + + ++DP G RTI +LT
Sbjct: 408 SGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLT 467
Query: 295 KPDLMDR--GTEKSVMNVVRNLTYPLKK-GYMIV 325
K DL ++ + + ++ +P+K GY V
Sbjct: 468 KVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAV 501
>gi|82880656 coiled-coil domain containing 46 isoform a [Homo
sapiens]
Length = 955
Score = 38.1 bits (87), Expect = 0.029
Identities = 58/257 (22%), Positives = 108/257 (42%), Gaps = 42/257 (16%)
Query: 370 LAERLTTELIMHIQKSLPLLEGQIRESHQKATEELRRCGADIPSQEADKMFFLIEKIKMF 429
L+ + +I +++++ L+ Q++ES + ++LR +++ +K
Sbjct: 497 LSASKASSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDL 556
Query: 430 NQDIEKLVEG--------EEVVRENETRLYNKIR-------------EDFKNWVGILATN 468
+++K E EE ++E E +L E+FK V + N
Sbjct: 557 QSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVEL---N 613
Query: 469 TQKVKNIIHEEVEKYEKQYRGKELLGFVNYKTF----EIIVHQYIQQLVEPALSMLQKAM 524
++KV + E++EK E + L K F E I +Y QQ+VE L Q+
Sbjct: 614 SEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKT 673
Query: 525 EIIQQAFINVAKKHFGEFFNLNQTVQSTIEDIKVKHTA---KAENMIQLQFRMEQMVFCQ 581
++QQ H E +L + + IE+++ + A + EN IQ +F+
Sbjct: 674 HLLQQ--------HNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQ-EFKKRDAQVIA 724
Query: 582 DQIYSVVLKKVREEIFN 598
D + K+REE+ N
Sbjct: 725 DM--EAQVHKLREELIN 739
>gi|4503917 growth arrest-specific 8 [Homo sapiens]
Length = 478
Score = 38.1 bits (87), Expect = 0.029
Identities = 38/173 (21%), Positives = 75/173 (43%), Gaps = 20/173 (11%)
Query: 381 HIQKSLPLLEGQ---IRESHQKATEELRRCGADIPSQEADKMFFLIEK--IKMFNQDIEK 435
H+++ + + GQ + + QKA EE+ + + E DK L K +K+ ++++
Sbjct: 264 HLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLCTKARLKVREKELKD 323
Query: 436 LVEGEEVVRENETRLYNKIREDFKNWVGILATNTQKV--KNIIHEE--------VEKYEK 485
L EV+ + T++ + E ++ + + QK KN++ E VEK E
Sbjct: 324 LQWEHEVLEQRFTKVQQERDELYRKFTAAIQEVQQKTGFKNLVLERKLQALSAAVEKKEV 383
Query: 486 QYRGKELLGFVNYKTFEIIVHQYIQQLVEPALSMLQKAMEIIQQAFINVAKKH 538
Q+ E+L N + + + + +E L ++ +Q V K H
Sbjct: 384 QF--NEVLAASNLDPAALTL---VSRKLEDVLESKNSTIKDLQYELAQVCKAH 431
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 37.0 bits (84), Expect = 0.064
Identities = 70/335 (20%), Positives = 137/335 (40%), Gaps = 34/335 (10%)
Query: 382 IQKSLPLLEGQIRESHQKATE------ELR-RCGADIPSQEADKMFFLIEKIKMFNQDIE 434
+QK L + E + + +K TE EL + IP+++ + M K + N+ E
Sbjct: 578 LQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENM-----KSSLSNEVNE 632
Query: 435 KLVEGEEVVRENETRLYNKIREDFKNWVGILATNTQKVKNIIHEEVEKYEKQYRGKELLG 494
K + E+ RE+E L ++IR+ + + A Q VK HE+V+ +Q G+
Sbjct: 633 KAKKLVEMEREHEKSL-SEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGE---- 687
Query: 495 FVNYKTFEIIV-HQYIQQLVEPALSMLQKAMEIIQQAFINVAKKHFGEFF---NLNQTVQ 550
+ K E+ + +Q +Q+ +E + E I + K H+ ++ ++
Sbjct: 688 -LGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEM-KNHYVPLKVSEDMKKSHD 745
Query: 551 STIEDIKVKHTAKAENMIQLQFRMEQMVFCQDQIYSVVLKKVREEIFNP--------LGT 602
+ I+D+ K + + + ME+++ D + V + E +F P +
Sbjct: 746 AIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRL--ETVFVPPEKHEKEIIAL 803
Query: 603 PSQNMKLNSHFPSNESSVSSFTEIGIHLNAYFLETSKRLANQ-IPFIIQYFMLRENGDSL 661
S ++L + E L + K ++NQ +P + D+L
Sbjct: 804 KSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTL 863
Query: 662 QKAMMQILQEKNRYSWLLQEQSETATKRRILKERI 696
K ++L K ++ + QE + K ILK +
Sbjct: 864 AKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNL 898
>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 1 [Homo sapiens]
Length = 1416
Score = 37.0 bits (84), Expect = 0.064
Identities = 70/335 (20%), Positives = 137/335 (40%), Gaps = 34/335 (10%)
Query: 382 IQKSLPLLEGQIRESHQKATE------ELR-RCGADIPSQEADKMFFLIEKIKMFNQDIE 434
+QK L + E + + +K TE EL + IP+++ + M K + N+ E
Sbjct: 591 LQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENM-----KSSLSNEVNE 645
Query: 435 KLVEGEEVVRENETRLYNKIREDFKNWVGILATNTQKVKNIIHEEVEKYEKQYRGKELLG 494
K + E+ RE+E L ++IR+ + + A Q VK HE+V+ +Q G+
Sbjct: 646 KAKKLVEMEREHEKSL-SEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGE---- 700
Query: 495 FVNYKTFEIIV-HQYIQQLVEPALSMLQKAMEIIQQAFINVAKKHFGEFF---NLNQTVQ 550
+ K E+ + +Q +Q+ +E + E I + K H+ ++ ++
Sbjct: 701 -LGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEM-KNHYVPLKVSEDMKKSHD 758
Query: 551 STIEDIKVKHTAKAENMIQLQFRMEQMVFCQDQIYSVVLKKVREEIFNP--------LGT 602
+ I+D+ K + + + ME+++ D + V + E +F P +
Sbjct: 759 AIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRL--ETVFVPPEKHEKEIIAL 816
Query: 603 PSQNMKLNSHFPSNESSVSSFTEIGIHLNAYFLETSKRLANQ-IPFIIQYFMLRENGDSL 661
S ++L + E L + K ++NQ +P + D+L
Sbjct: 817 KSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTL 876
Query: 662 QKAMMQILQEKNRYSWLLQEQSETATKRRILKERI 696
K ++L K ++ + QE + K ILK +
Sbjct: 877 AKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNL 911
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 36.6 bits (83), Expect = 0.083
Identities = 27/131 (20%), Positives = 64/131 (48%), Gaps = 13/131 (9%)
Query: 341 EATKKEITFFQTHPYFRVLLEEGSATVPRLAERLTTELIMHIQKSLPLLEGQIRESHQKA 400
E K+ ++ +T + L + S + RL + + + + Q++ +L+ Q++E+ ++
Sbjct: 922 ETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKE-QETTGILQTQLQEAQREL 980
Query: 401 TEELRRCGADIPSQEADKMFFLIEKIKMFNQ------------DIEKLVEGEEVVRENET 448
E R+ D+ + + + L +K+ + Q D ++LVE E + ET
Sbjct: 981 KEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRET 1040
Query: 449 RLYNKIREDFK 459
+ YN+I+++ +
Sbjct: 1041 QEYNRIQKELE 1051
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 35.4 bits (80), Expect = 0.19
Identities = 47/222 (21%), Positives = 94/222 (42%), Gaps = 26/222 (11%)
Query: 360 LEEGSATVPRLAERLTTELIMHIQKSLPLLEGQIRESHQKATEELRRCGADIPSQEA--- 416
+E +AT+ + L T+L ++ L+ QI + Q+ T L+ + +Q A
Sbjct: 1051 VERNNATLQAEKQALKTQL-KQLETQNNNLQAQIL-ALQRQTVSLQEQNTTLQTQNAKLQ 1108
Query: 417 -DKMFFLIEKIKMFNQDIEKLVEGEEVVRENETRLYNKIREDFKNWVGILATNTQKVKNI 475
+ + + NQ+ + L++ + ENE+ + K RED K+ L + +K++ +
Sbjct: 1109 VENSTLNSQSTSLMNQNAQLLIQQSSLENENESVI--KEREDLKSLYDSLIKDHEKLELL 1166
Query: 476 IHEEVEKYEKQYRGKELLGF------VNYKTFEIIVHQYIQQLVEPALSMLQKAMEIIQQ 529
+ +YE L V ++ E +Q ++Q + L L+K +++ Q+
Sbjct: 1167 HERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQ--KGQLEDLEKMLKVEQE 1224
Query: 530 AFINVAKKH----------FGEFFNLNQTVQSTIEDIKVKHT 561
+ K H GE LN T +++ +V T
Sbjct: 1225 KMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQT 1266
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 35.4 bits (80), Expect = 0.19
Identities = 47/222 (21%), Positives = 94/222 (42%), Gaps = 26/222 (11%)
Query: 360 LEEGSATVPRLAERLTTELIMHIQKSLPLLEGQIRESHQKATEELRRCGADIPSQEA--- 416
+E +AT+ + L T+L ++ L+ QI + Q+ T L+ + +Q A
Sbjct: 1050 VERNNATLQAEKQALKTQL-KQLETQNNNLQAQIL-ALQRQTVSLQEQNTTLQTQNAKLQ 1107
Query: 417 -DKMFFLIEKIKMFNQDIEKLVEGEEVVRENETRLYNKIREDFKNWVGILATNTQKVKNI 475
+ + + NQ+ + L++ + ENE+ + K RED K+ L + +K++ +
Sbjct: 1108 VENSTLNSQSTSLMNQNAQLLIQQSSLENENESVI--KEREDLKSLYDSLIKDHEKLELL 1165
Query: 476 IHEEVEKYEKQYRGKELLGF------VNYKTFEIIVHQYIQQLVEPALSMLQKAMEIIQQ 529
+ +YE L V ++ E +Q ++Q + L L+K +++ Q+
Sbjct: 1166 HERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQ--KGQLEDLEKMLKVEQE 1223
Query: 530 AFINVAKKH----------FGEFFNLNQTVQSTIEDIKVKHT 561
+ K H GE LN T +++ +V T
Sbjct: 1224 KMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQT 1265
>gi|117968420 NUF2, NDC80 kinetochore complex component [Homo
sapiens]
Length = 464
Score = 35.4 bits (80), Expect = 0.19
Identities = 26/102 (25%), Positives = 45/102 (44%), Gaps = 1/102 (0%)
Query: 383 QKSLPLLEGQIRESHQKATEELRRCGADIPSQEADKMFFLIEKIKMFNQDIEKLVEGEEV 442
Q+ L I+E Q ++ + + + K + EK K N+ +V +E+
Sbjct: 177 QEEFKQLSDGIQELQQSLNQDFHQKTIVLQEGNSQKKSNISEKTKRLNELKLSVVSLKEI 236
Query: 443 VRENETRLYNKIREDFKNWVGILATNTQKVKNIIHEEVEKYE 484
+T++ + E KN+ + QK+KN E VEKYE
Sbjct: 237 QESLKTKIVDS-PEKLKNYKEKMKDTVQKLKNARQEVVEKYE 277
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.381
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,040,666
Number of Sequences: 37866
Number of extensions: 1196122
Number of successful extensions: 3988
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 23
Number of HSP's successfully gapped in prelim test: 66
Number of HSP's that attempted gapping in prelim test: 3856
Number of HSP's gapped (non-prelim): 150
length of query: 715
length of database: 18,247,518
effective HSP length: 109
effective length of query: 606
effective length of database: 14,120,124
effective search space: 8556795144
effective search space used: 8556795144
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.