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Search of human proteins with 20149626
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|20149626 pleckstrin homology domain containing, family O
member 1 [Homo sapiens]
(409 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|20149626 pleckstrin homology domain containing, family O memb... 815 0.0
gi|33457316 pleckstrin homology domain containing, family O memb... 131 1e-30
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 45 2e-04
gi|45827716 ADP-ribosylation factor guanine nucleotide factor 6 ... 45 2e-04
gi|117606360 ADP-ribosylation factor guanine nucleotide factor 6... 45 2e-04
gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo sa... 44 3e-04
gi|194733753 phosphoinositide-binding protein PIP3-E isoform 1 [... 44 3e-04
gi|194733747 phosphoinositide-binding protein PIP3-E isoform 1 [... 44 3e-04
gi|40354212 phosphoinositide-binding protein PIP3-E isoform 2 [H... 44 3e-04
gi|4758964 cytohesin 1 isoform 1 [Homo sapiens] 43 6e-04
gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo ... 43 6e-04
gi|110349763 cytohesin 1 isoform 2 [Homo sapiens] 42 8e-04
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 41 0.002
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 41 0.002
gi|120953251 neuron navigator 3 [Homo sapiens] 41 0.002
gi|4758968 cytohesin 3 [Homo sapiens] 41 0.002
gi|4502023 AKT2 kinase [Homo sapiens] 40 0.003
gi|7019505 cytohesin 4 [Homo sapiens] 39 0.007
gi|50234893 pleckstrin homology domain containing, family A (pho... 39 0.007
gi|31377720 pleckstrin homology domain containing, family A (pho... 39 0.007
gi|239745299 PREDICTED: hypothetical protein [Homo sapiens] 39 0.009
gi|62241015 AKT1 kinase [Homo sapiens] 39 0.011
gi|62241013 AKT1 kinase [Homo sapiens] 39 0.011
gi|62241011 AKT1 kinase [Homo sapiens] 39 0.011
gi|22003858 ventricular zone expressed PH domain homolog 1 [Homo... 39 0.011
gi|239745087 PREDICTED: similar to Golgin subfamily A member 8-l... 38 0.019
gi|239745081 PREDICTED: similar to Golgin subfamily A member 8-l... 38 0.019
gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens] 38 0.019
gi|48255891 protein kinase C substrate 80K-H isoform 2 [Homo sap... 37 0.025
gi|29788760 diacylglycerol kinase, eta isoform 1 [Homo sapiens] 36 0.055
>gi|20149626 pleckstrin homology domain containing, family O member
1 [Homo sapiens]
Length = 409
Score = 815 bits (2106), Expect = 0.0
Identities = 409/409 (100%), Positives = 409/409 (100%)
Query: 1 MMKKNNSAKRGPQDGNQQPAPPEKVGWVRKFCGKGIFREIWKNRYVVLKGDQLYISEKEV 60
MMKKNNSAKRGPQDGNQQPAPPEKVGWVRKFCGKGIFREIWKNRYVVLKGDQLYISEKEV
Sbjct: 1 MMKKNNSAKRGPQDGNQQPAPPEKVGWVRKFCGKGIFREIWKNRYVVLKGDQLYISEKEV 60
Query: 61 KDEKNIQEVFDLSDYEKCEELRKSKSRSKKNHSKFTLAHSKQPGNTAPNLIFLAVSPEEK 120
KDEKNIQEVFDLSDYEKCEELRKSKSRSKKNHSKFTLAHSKQPGNTAPNLIFLAVSPEEK
Sbjct: 61 KDEKNIQEVFDLSDYEKCEELRKSKSRSKKNHSKFTLAHSKQPGNTAPNLIFLAVSPEEK 120
Query: 121 ESWINALNSAITRAKNRILDEVTVEEDSYLAHPTRDRAKIQHSRRPPTRGHLMAVASTST 180
ESWINALNSAITRAKNRILDEVTVEEDSYLAHPTRDRAKIQHSRRPPTRGHLMAVASTST
Sbjct: 121 ESWINALNSAITRAKNRILDEVTVEEDSYLAHPTRDRAKIQHSRRPPTRGHLMAVASTST 180
Query: 181 SDGMLTLDLIQEEDPSPEEPTSCAESFRVDLDKSVAQLAGSRRRADSDRIQPSADRASSL 240
SDGMLTLDLIQEEDPSPEEPTSCAESFRVDLDKSVAQLAGSRRRADSDRIQPSADRASSL
Sbjct: 181 SDGMLTLDLIQEEDPSPEEPTSCAESFRVDLDKSVAQLAGSRRRADSDRIQPSADRASSL 240
Query: 241 SRPWEKTDKGATYTPQAPKKLTPTEKGRCASLEEILSQRDAASARTLQLRAEEPPTPALP 300
SRPWEKTDKGATYTPQAPKKLTPTEKGRCASLEEILSQRDAASARTLQLRAEEPPTPALP
Sbjct: 241 SRPWEKTDKGATYTPQAPKKLTPTEKGRCASLEEILSQRDAASARTLQLRAEEPPTPALP 300
Query: 301 NPGQLSRIQDLVARKLEETQELLAEVQGLGDGKRKAKDPPRSPPDSESEQLLLETERLLG 360
NPGQLSRIQDLVARKLEETQELLAEVQGLGDGKRKAKDPPRSPPDSESEQLLLETERLLG
Sbjct: 301 NPGQLSRIQDLVARKLEETQELLAEVQGLGDGKRKAKDPPRSPPDSESEQLLLETERLLG 360
Query: 361 EASSNWSQAKRVLQEVRELRDLYRQMDLQTPDSHLRQTTPHSQYRKSLM 409
EASSNWSQAKRVLQEVRELRDLYRQMDLQTPDSHLRQTTPHSQYRKSLM
Sbjct: 361 EASSNWSQAKRVLQEVRELRDLYRQMDLQTPDSHLRQTTPHSQYRKSLM 409
>gi|33457316 pleckstrin homology domain containing, family O member
2 [Homo sapiens]
Length = 490
Score = 131 bits (330), Expect = 1e-30
Identities = 112/334 (33%), Positives = 153/334 (45%), Gaps = 37/334 (11%)
Query: 23 EKVGWVRKFCGKGIFREIWKNRYVVLKGDQLYISEKEVKDEKNIQEVFDLSDYEKCEELR 82
+K GW++K G G+ WK+RY++L QL + E E D++ E +L YEKC++LR
Sbjct: 20 DKAGWIKKSSG-GLLG-FWKDRYLLLCQAQLLVYENE--DDQKCVETVELGSYEKCQDLR 75
Query: 83 KSKSRSKKNHSKFTLAHSKQPGNTAPNLIFLAVSPEEKESWINALNSAITRAKNRILDEV 142
+ K+ H +F L S PGN ++ F A + EEKESWI ALN I R KN+ DEV
Sbjct: 76 ---ALLKRKH-RFILLRS--PGNKVSDIKFQAPTGEEKESWIKALNEGINRGKNKAFDEV 129
Query: 143 TVEEDSYLAHPTRDRAKIQHSRRPPTRGHLMAVASTSTSDGMLTLDLIQEEDPSPEEPTS 202
V++ L H TRDR + RRPPTR HL VAS + SDG+L LDL + P S
Sbjct: 130 KVDKSCALEHVTRDRVRGGQRRRPPTRVHLKEVAS-AASDGLLRLDL--------DVPDS 180
Query: 203 CAESFRVDLDKSVAQLAGSRRRADSDRIQPSADRASSLSRPWEKTDKGATYTPQAPKKLT 262
F S AQ + R P P + TP + T
Sbjct: 181 GPPVFAPSNHVSEAQPRETPR--------PLMPPTKPFLAPETTSPGDRVETPVGERAPT 232
Query: 263 PTEKGRCASLEEILSQRDAASARTLQLRAEEPPTPALPNPGQL-----SRIQDLVARKLE 317
P S E SQ D+ + +E+PP LP+ ++ S + A E
Sbjct: 233 PVSASSEVSPE---SQEDSETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAE 289
Query: 318 ETQELLAEVQGLGDGKRKAKDPPRSPPDSESEQL 351
+Q +E R+ PP PP SE+L
Sbjct: 290 PSQAPCSETSEA--APREGGKPPTPPPKILSEKL 321
Score = 38.5 bits (88), Expect = 0.011
Identities = 62/258 (24%), Positives = 88/258 (34%), Gaps = 49/258 (18%)
Query: 141 EVTVEEDSYLAHPTR----DRAKIQHSRRPPTRGHLMAVASTSTSDGMLTLDLIQEEDPS 196
E EEDS P D+ K+ P A S + T + E
Sbjct: 249 ETPAEEDSGSEQPPNSVLPDKLKVSWENPSPQEAPAAESAEPSQAPCSETSEAAPREGGK 308
Query: 197 PEEPTSCAESFRVDLDKSVAQLAGSRRRADS---------DRIQPSADRASSLSRPWEKT 247
P PT + L S+ ++ S A D A + + P
Sbjct: 309 P--PTPPPKILSEKLKASMGEMQASGPPAPGTVQVSVNGMDDSPEPAKPSQAEGTPGTPP 366
Query: 248 DKGATYTPQAPKKLTPTEKGRCASLEEILSQRDAASARTLQLRAEEPPTPALPNPGQLSR 307
T T P L P RC+SL ++L E P P P +L R
Sbjct: 367 KDATTSTALPPWDLPPQFHPRCSSLGDLLG--------------EGPRHPLQPRE-RLYR 411
Query: 308 IQDLVARKLEETQELLAEVQGLGDGKRKAKDPPRSPPDSESEQLLLETERLLGEASSNWS 367
Q V E+T++LL +V G SE + E LL +A
Sbjct: 412 AQLEVKVASEQTEKLLNKVLG-------------------SEPAPVSAETLLSQAVEQLR 452
Query: 368 QAKRVLQEVRELRDLYRQ 385
QA +VLQE+R+L +L ++
Sbjct: 453 QATQVLQEMRDLGELSQE 470
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 44.7 bits (104), Expect = 2e-04
Identities = 55/271 (20%), Positives = 102/271 (37%), Gaps = 11/271 (4%)
Query: 76 EKCEELRKSKSRSKKNHSKFTLAHSKQPGNTAPNLIFLAVSPEEKESWINALNSAITRAK 135
EK + K +++S + A +K P + A SPE+ +S + + +AK
Sbjct: 650 EKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAK 709
Query: 136 NRILDEVTVEEDSYLAHPTRDRAKIQHSRRPPTRGHLMAVASTSTSDGMLTLDLIQEE-- 193
+ + +E E + P ++ AK + P + + + + TLD+ E
Sbjct: 710 SPVKEEAKSPEKA--KSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAK 767
Query: 194 DPSPEEPTSCAESFRVDLDKSVAQLAGSRRRADSDRIQPSADRASSLSRPWEKTDKGATY 253
P+ EE S A+ F V + S +A S + + +A P ++ K
Sbjct: 768 TPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDA--KAPEKEIPKKEEVKSPVK 825
Query: 254 TPQAPKKLTPTEKGRCASLEEILSQRDAASARTLQLRAEEPPTPALPNPGQLSRIQDLVA 313
+ P+++ E + A EE + + + EE P P P + + V
Sbjct: 826 EEEKPQEVKVKEPPKKA--EEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVE 883
Query: 314 RKLEETQELLAEVQGLGDGKRKAKDPPRSPP 344
+ E E E + K+K P + P
Sbjct: 884 KPKESKVEAKKEE---AEDKKKVPTPEKEAP 911
>gi|45827716 ADP-ribosylation factor guanine nucleotide factor 6
isoform b [Homo sapiens]
Length = 513
Score = 44.7 bits (104), Expect = 2e-04
Identities = 34/94 (36%), Positives = 45/94 (47%), Gaps = 17/94 (18%)
Query: 41 WKNRYVVLKGDQLYISEKEVKDEKNIQEVFDLSDYEKCEELRKSKSRSKKNHSKFTLAHS 100
WK Y VLKG LY+ + E K EK + E E+L+ + S SK T +
Sbjct: 277 WKTFYAVLKGTVLYLQKDEYKPEKALSE----------EDLKNAVSVHHALASKAT-DYE 325
Query: 101 KQPG----NTAP--NLIFLAVSPEEKESWINALN 128
K+P TA L+F SPEE + WIN +N
Sbjct: 326 KKPNVFKLKTADWRVLLFQTQSPEEMQGWINKIN 359
>gi|117606360 ADP-ribosylation factor guanine nucleotide factor 6
isoform a [Homo sapiens]
Length = 1047
Score = 44.7 bits (104), Expect = 2e-04
Identities = 34/94 (36%), Positives = 45/94 (47%), Gaps = 17/94 (18%)
Query: 41 WKNRYVVLKGDQLYISEKEVKDEKNIQEVFDLSDYEKCEELRKSKSRSKKNHSKFTLAHS 100
WK Y VLKG LY+ + E K EK + E E+L+ + S SK T +
Sbjct: 811 WKTFYAVLKGTVLYLQKDEYKPEKALSE----------EDLKNAVSVHHALASKAT-DYE 859
Query: 101 KQPG----NTAP--NLIFLAVSPEEKESWINALN 128
K+P TA L+F SPEE + WIN +N
Sbjct: 860 KKPNVFKLKTADWRVLLFQTQSPEEMQGWINKIN 893
>gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo
sapiens]
Length = 748
Score = 43.9 bits (102), Expect = 3e-04
Identities = 25/58 (43%), Positives = 33/58 (56%), Gaps = 4/58 (6%)
Query: 2 MKKNNSAKRGPQDGNQQPAPPEKVGWVRKFCGKGIFREIWKNRYVVLKGDQLYISEKE 59
M++NN + PQ G Q K GW+RK +G F + W R+ VLKGDQLY + E
Sbjct: 1 MEENNDSTENPQQG-QGRQNAIKCGWLRK---QGGFVKTWHTRWFVLKGDQLYYFKDE 54
>gi|194733753 phosphoinositide-binding protein PIP3-E isoform 1
[Homo sapiens]
Length = 438
Score = 43.5 bits (101), Expect = 3e-04
Identities = 44/189 (23%), Positives = 71/189 (37%), Gaps = 19/189 (10%)
Query: 26 GWVRKFCGKGIF-REIWKNRYVVLKGDQLYISEKEVKDEKNIQEVFDLSDYEKCEELRKS 84
GW+ K KG F WK +V+LKG LY ++ ++ + +L D+ +
Sbjct: 47 GWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKAD--GFVNLPDFTV-----ER 99
Query: 85 KSRSKKNHSKFTLAHSKQPGNTAPNLIFLAVSPEEKESWINALNSAITRAKNRILDEVTV 144
S KK H+ F ++H + F A + +E W+N L SA+ + T
Sbjct: 100 ASECKKKHA-FKISHPQ-----IKTFYFAAENVQEMNVWLNKLGSAVIHQ-----ESTTK 148
Query: 145 EEDSYLAHPTRDRAKIQHSRRPPTRGHLMAVASTSTSDGMLTLDLIQEEDPSPEEPTSCA 204
+E+ Y D + PP ++ + S +L S E
Sbjct: 149 DEECYSESEQEDPEIAAETPPPPHASQTQSLTAQQASSSSPSLSGTSYSFSSLENTVKTP 208
Query: 205 ESFRVDLDK 213
SF L K
Sbjct: 209 SSFPSSLSK 217
>gi|194733747 phosphoinositide-binding protein PIP3-E isoform 1
[Homo sapiens]
Length = 438
Score = 43.5 bits (101), Expect = 3e-04
Identities = 44/189 (23%), Positives = 71/189 (37%), Gaps = 19/189 (10%)
Query: 26 GWVRKFCGKGIF-REIWKNRYVVLKGDQLYISEKEVKDEKNIQEVFDLSDYEKCEELRKS 84
GW+ K KG F WK +V+LKG LY ++ ++ + +L D+ +
Sbjct: 47 GWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKAD--GFVNLPDFTV-----ER 99
Query: 85 KSRSKKNHSKFTLAHSKQPGNTAPNLIFLAVSPEEKESWINALNSAITRAKNRILDEVTV 144
S KK H+ F ++H + F A + +E W+N L SA+ + T
Sbjct: 100 ASECKKKHA-FKISHPQ-----IKTFYFAAENVQEMNVWLNKLGSAVIHQ-----ESTTK 148
Query: 145 EEDSYLAHPTRDRAKIQHSRRPPTRGHLMAVASTSTSDGMLTLDLIQEEDPSPEEPTSCA 204
+E+ Y D + PP ++ + S +L S E
Sbjct: 149 DEECYSESEQEDPEIAAETPPPPHASQTQSLTAQQASSSSPSLSGTSYSFSSLENTVKTP 208
Query: 205 ESFRVDLDK 213
SF L K
Sbjct: 209 SSFPSSLSK 217
>gi|40354212 phosphoinositide-binding protein PIP3-E isoform 2 [Homo
sapiens]
Length = 437
Score = 43.5 bits (101), Expect = 3e-04
Identities = 44/189 (23%), Positives = 71/189 (37%), Gaps = 19/189 (10%)
Query: 26 GWVRKFCGKGIF-REIWKNRYVVLKGDQLYISEKEVKDEKNIQEVFDLSDYEKCEELRKS 84
GW+ K KG F WK +V+LKG LY ++ ++ + +L D+ +
Sbjct: 46 GWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKAD--GFVNLPDFTV-----ER 98
Query: 85 KSRSKKNHSKFTLAHSKQPGNTAPNLIFLAVSPEEKESWINALNSAITRAKNRILDEVTV 144
S KK H+ F ++H + F A + +E W+N L SA+ + T
Sbjct: 99 ASECKKKHA-FKISHPQ-----IKTFYFAAENVQEMNVWLNKLGSAVIHQ-----ESTTK 147
Query: 145 EEDSYLAHPTRDRAKIQHSRRPPTRGHLMAVASTSTSDGMLTLDLIQEEDPSPEEPTSCA 204
+E+ Y D + PP ++ + S +L S E
Sbjct: 148 DEECYSESEQEDPEIAAETPPPPHASQTQSLTAQQASSSSPSLSGTSYSFSSLENTVKTP 207
Query: 205 ESFRVDLDK 213
SF L K
Sbjct: 208 SSFPSSLSK 216
>gi|4758964 cytohesin 1 isoform 1 [Homo sapiens]
Length = 398
Score = 42.7 bits (99), Expect = 6e-04
Identities = 40/142 (28%), Positives = 59/142 (41%), Gaps = 15/142 (10%)
Query: 4 KNNSAKRGPQDGNQQPAP---PEKVGWVRKFCGKGIFREIWKNRYVVLKGDQLYISEKEV 60
KN K DGN P++ GW+ K G + + WK R+ +L + LY E
Sbjct: 240 KNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRV--KTWKRRWFILTDNCLYYFEYTT 297
Query: 61 KDEK---------NIQEVFDLSDYEKCEELRKSKSRSKKNHSKFTLAHSKQPGNTAPNLI 111
E +I+EV D S C EL ++ + + T A +
Sbjct: 298 DKEPRGIIPLENLSIREVED-SKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYR 356
Query: 112 FLAVSPEEKESWINALNSAITR 133
A +PEEKE WI + +AI+R
Sbjct: 357 ISAPTPEEKEEWIKCIKAAISR 378
>gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo
sapiens]
Length = 1048
Score = 42.7 bits (99), Expect = 6e-04
Identities = 38/128 (29%), Positives = 60/128 (46%), Gaps = 18/128 (14%)
Query: 3 KKNNSAKRGPQDGNQQPAPPEKVGWVRKFCGKGIFREIWKNRYVVLKGDQLYISEKEVKD 62
K+++S KR P AP K GW+ K G+ + W R+ VL D+ K+ K+
Sbjct: 47 KRSHSMKRNPN------APVTKAGWLFKQASSGVKQ--WNKRWFVLV-DRCLFYYKDEKE 97
Query: 63 EKNIQEVFDLSDYEKCEELRKSKSRSKKNHSKFTLAHSKQPGNTAPNLIFLAVSPEEKES 122
E + + LS + ++ S + S+K+ K A + F A SPEE+E+
Sbjct: 98 ESILGSIPLLSF--RVAAVQPSDNISRKHTFKAEHAGVR-------TYFFSAESPEEQEA 148
Query: 123 WINALNSA 130
WI A+ A
Sbjct: 149 WIQAMGEA 156
>gi|110349763 cytohesin 1 isoform 2 [Homo sapiens]
Length = 397
Score = 42.4 bits (98), Expect = 8e-04
Identities = 40/142 (28%), Positives = 59/142 (41%), Gaps = 16/142 (11%)
Query: 4 KNNSAKRGPQDGNQQPAP---PEKVGWVRKFCGKGIFREIWKNRYVVLKGDQLYISEKEV 60
KN K DGN P++ GW+ K G+ + WK R+ +L + LY E
Sbjct: 240 KNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRV---KTWKRRWFILTDNCLYYFEYTT 296
Query: 61 KDEK---------NIQEVFDLSDYEKCEELRKSKSRSKKNHSKFTLAHSKQPGNTAPNLI 111
E +I+EV D S C EL ++ + + T A +
Sbjct: 297 DKEPRGIIPLENLSIREVED-SKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYR 355
Query: 112 FLAVSPEEKESWINALNSAITR 133
A +PEEKE WI + +AI+R
Sbjct: 356 ISAPTPEEKEEWIKCIKAAISR 377
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 41.2 bits (95), Expect = 0.002
Identities = 34/145 (23%), Positives = 59/145 (40%), Gaps = 12/145 (8%)
Query: 24 KVGWVRKFCGKGIFREIWKNRYVVLKGDQLYISEKEVKDEKNIQEVFDLSDYEKCEELRK 83
K GWV+K +G + + W+ RY +LK D +I KE + ++ + KC+ ++
Sbjct: 8 KEGWVQK---RGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQLMK- 63
Query: 84 SKSRSKKNHSKFTLAHSKQPGNTAPNLIFLAVSPEEKESWINALNSAITRAKNRILDEVT 143
R K N T T F +PEE+E W A+ + R + + + +
Sbjct: 64 -TERPKPN----TFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMN 118
Query: 144 VEEDSY---LAHPTRDRAKIQHSRR 165
S + D + H R+
Sbjct: 119 CSPTSQIDNIGEEEMDASTTHHKRK 143
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 41.2 bits (95), Expect = 0.002
Identities = 34/145 (23%), Positives = 59/145 (40%), Gaps = 12/145 (8%)
Query: 24 KVGWVRKFCGKGIFREIWKNRYVVLKGDQLYISEKEVKDEKNIQEVFDLSDYEKCEELRK 83
K GWV+K +G + + W+ RY +LK D +I KE + ++ + KC+ ++
Sbjct: 8 KEGWVQK---RGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQLMK- 63
Query: 84 SKSRSKKNHSKFTLAHSKQPGNTAPNLIFLAVSPEEKESWINALNSAITRAKNRILDEVT 143
R K N T T F +PEE+E W A+ + R + + + +
Sbjct: 64 -TERPKPN----TFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMN 118
Query: 144 VEEDSY---LAHPTRDRAKIQHSRR 165
S + D + H R+
Sbjct: 119 CSPTSQIDNIGEEEMDASTTHHKRK 143
>gi|120953251 neuron navigator 3 [Homo sapiens]
Length = 2363
Score = 40.8 bits (94), Expect = 0.002
Identities = 62/294 (21%), Positives = 111/294 (37%), Gaps = 32/294 (10%)
Query: 98 AHSKQPGNTAPNLIFLAVSPEEKESWINALNSAI--TRAKNRILDEVTVEEDSYLAHPTR 155
A K GN L L ++ E+KES + L I +A+N + HP +
Sbjct: 1601 AFEKSLGNMTGRLQSLTMTAEQKESELIELRETIEMLKAQNSAAQAAIQGALNGPDHPPK 1660
Query: 156 D-RAKIQHSRRPPTRGHLMAVASTSTSDGMLTLDLIQEEDPSPEEPTSCAESFRVDLDKS 214
D R + QHS +V+S +++ ++ + D ++ + S +L S
Sbjct: 1661 DLRIRRQHSSE--------SVSSINSATSHSSIGSGNDADSKKKKKKNWVNSRGSELRSS 1712
Query: 215 VAQLAGSRRRADSDRIQPSADRASSLSRPWEKTDKGATYTPQAP--------KKLTPTEK 266
Q G ++ S SS S E TD +P+ P + P++
Sbjct: 1713 FKQAFGKKK---------STKPPSSHSDIEELTDSSLPASPKLPHNAGDCGSASMKPSQS 1763
Query: 267 G----RCASLEEILSQRDAASARTLQLRAEEPPTPALPNPGQLSRIQDLVARKLEETQEL 322
C E + + + R +L+ + AL + L +I++ + R E + L
Sbjct: 1764 ASAICECTEAEAEIILQLKSELREKELKLTDIRLEALSSAHHLDQIREAMNRMQNEIEIL 1823
Query: 323 LAEVQGLGDGKRKAKDPPRSPPDSESEQLLLETERLLGEASSNWSQAKRVLQEV 376
AE L P R P +S S + + LG + +N + + V ++
Sbjct: 1824 KAENDRLKAETGNTAKPTRPPSESSSSTSSSSSRQSLGLSLNNLNITEAVSSDI 1877
>gi|4758968 cytohesin 3 [Homo sapiens]
Length = 399
Score = 40.8 bits (94), Expect = 0.002
Identities = 38/141 (26%), Positives = 60/141 (42%), Gaps = 14/141 (9%)
Query: 4 KNNSAKRGPQDGNQQPAP---PEKVGWVRKFCGKGIFREIWKNRYVVLKGDQLYISEKEV 60
KN K DGN P++ GW+ K G+ + WK R+ +L + LY E
Sbjct: 244 KNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRV---KTWKRRWFILTDNCLYYFEYTT 300
Query: 61 -KDEKNIQEVFDLSDYE-------KCEELRKSKSRSKKNHSKFTLAHSKQPGNTAPNLIF 112
K+ + I + +LS E C EL + + + T A +
Sbjct: 301 DKEPRGIIPLENLSIREVEDPRKPNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYRI 360
Query: 113 LAVSPEEKESWINALNSAITR 133
A SPEEKE W+ ++ ++I+R
Sbjct: 361 SAPSPEEKEEWMKSIKASISR 381
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 40.4 bits (93), Expect = 0.003
Identities = 31/114 (27%), Positives = 48/114 (42%), Gaps = 8/114 (7%)
Query: 24 KVGWVRKFCGKGIFREIWKNRYVVLKGDQLYISEKEVKDEKNIQEVFDLSDYEKCEELRK 83
K GW+ K +G + + W+ RY +LK D +I KE + E Q + L+++ E
Sbjct: 8 KEGWLHK---RGEYIKTWRPRYFLLKSDGSFIGYKE-RPEAPDQTLPPLNNFSVAECQLM 63
Query: 84 SKSRSKKNHSKFTLAHSKQPGNTAPNLIFLAVSPEEKESWINALNSAITRAKNR 137
R + N T T F SP+E+E W+ A+ K R
Sbjct: 64 KTERPRPN----TFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQR 113
>gi|7019505 cytohesin 4 [Homo sapiens]
Length = 394
Score = 39.3 bits (90), Expect = 0.007
Identities = 33/120 (27%), Positives = 56/120 (46%), Gaps = 11/120 (9%)
Query: 22 PEKVGWVRKFCGKGIFREIWKNRYVVLKGDQLYISEKEV-KDEKNIQEVFDLS-----DY 75
P++ GW+ K G+ + WK R+ +L + LY E K+ + I + +LS D
Sbjct: 260 PDREGWLLKLGGRV---KTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLENLSVQKVDDP 316
Query: 76 EK--CEELRKSKSRSKKNHSKFTLAHSKQPGNTAPNLIFLAVSPEEKESWINALNSAITR 133
+K C EL R +K + T + + A S EE++ WI ++ ++ITR
Sbjct: 317 KKPFCLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSAEERDQWIESIRASITR 376
>gi|50234893 pleckstrin homology domain containing, family A
(phosphoinositide binding specific) member 1 [Homo
sapiens]
Length = 404
Score = 39.3 bits (90), Expect = 0.007
Identities = 32/115 (27%), Positives = 50/115 (43%), Gaps = 12/115 (10%)
Query: 19 PAPPEKVGWVRK-FCGK-GIFREIWKNRYVVLKGDQLYISEKEVKDEKNIQEVFDLSDYE 76
P PP+ ++ +C K G + WK RY L + + + E+ EK V L +
Sbjct: 184 PKPPQDSAVIKAGYCVKQGAVMKNWKRRYFQLDENTIGYFKSEL--EKEPLRVIPLKEVH 241
Query: 77 KCEELRKSKSRSKKNHSKFTLAHSKQPGNTAPNLIFLAVSPEEKESWINALNSAI 131
K +E ++S + N + T+ A SPEE SWI A++ AI
Sbjct: 242 KVQECKQSDIMMRDNLFEIV--------TTSRTFYVQADSPEEMHSWIKAVSGAI 288
>gi|31377720 pleckstrin homology domain containing, family A
(phosphoinositide binding specific) member 1 [Homo
sapiens]
Length = 404
Score = 39.3 bits (90), Expect = 0.007
Identities = 32/115 (27%), Positives = 50/115 (43%), Gaps = 12/115 (10%)
Query: 19 PAPPEKVGWVRK-FCGK-GIFREIWKNRYVVLKGDQLYISEKEVKDEKNIQEVFDLSDYE 76
P PP+ ++ +C K G + WK RY L + + + E+ EK V L +
Sbjct: 184 PKPPQDSAVIKAGYCVKQGAVMKNWKRRYFQLDENTIGYFKSEL--EKEPLRVIPLKEVH 241
Query: 77 KCEELRKSKSRSKKNHSKFTLAHSKQPGNTAPNLIFLAVSPEEKESWINALNSAI 131
K +E ++S + N + T+ A SPEE SWI A++ AI
Sbjct: 242 KVQECKQSDIMMRDNLFEIV--------TTSRTFYVQADSPEEMHSWIKAVSGAI 288
>gi|239745299 PREDICTED: hypothetical protein [Homo sapiens]
Length = 523
Score = 38.9 bits (89), Expect = 0.009
Identities = 50/224 (22%), Positives = 91/224 (40%), Gaps = 18/224 (8%)
Query: 191 QEEDPSPEEPTSCAESFRVDLDKSVAQLAGSRRRADSDRIQPSADRASSLSRPWEKTDKG 250
QEE +E C + R+ + + R +R++ +R L E+ +
Sbjct: 211 QEERLREQEERLCEQEERLREQEERLREQEERLCEQEERLREHEER---LCEQEERLCEQ 267
Query: 251 ATYTPQAPKKLTPTEKGRCASLEEILSQRDAASARTLQLRAEEPPTPALPNPGQLSRIQD 310
+ ++L E+ C E + Q + + +LR +E Q R+++
Sbjct: 268 EERLREQEERLHEQEERLCEQEERLREQEERLCEQEERLREQEERLCE-----QEERLRE 322
Query: 311 LVAR-----KLEETQELLAEVQGLGDGKRKAKDPPRSPPDS---ESEQLLLETERLLGEA 362
R KL + LL EV+ L + +R+ ++ R E + LLE ERL +
Sbjct: 323 QEERLCEQEKLPGQERLLEEVEKLLEQERRQEEQERLLERERLLEEVEELLEQERLRQQD 382
Query: 363 SSNWSQAKRVLQEVRELRDLYRQMDLQTPDSHLRQTTPHSQYRK 406
W Q LQE+ LR+L R ++L + ++ P S + +
Sbjct: 383 ERLWQQ--ETLQELERLRELERMLELGWEALYEQRAEPRSGFEE 424
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 38.5 bits (88), Expect = 0.011
Identities = 30/127 (23%), Positives = 55/127 (43%), Gaps = 12/127 (9%)
Query: 24 KVGWVRKFCGKGIFREIWKNRYVVLKGDQLYISEKEVKDEKNIQEVFDLSDYE--KCEEL 81
K GW+ K +G + + W+ RY +LK D +I KE + + +E L+++ +C+ +
Sbjct: 8 KEGWLHK---RGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREA-PLNNFSVAQCQLM 63
Query: 82 RKSKSRSKKNHSKFTLAHSKQPGNTAPNLIFLAVSPEEKESWINALNSAITRAKNRILDE 141
+ + R T T F +PEE+E W A+ + K + +E
Sbjct: 64 KTERPRPN------TFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEE 117
Query: 142 VTVEEDS 148
+ S
Sbjct: 118 MDFRSGS 124
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 38.5 bits (88), Expect = 0.011
Identities = 30/127 (23%), Positives = 55/127 (43%), Gaps = 12/127 (9%)
Query: 24 KVGWVRKFCGKGIFREIWKNRYVVLKGDQLYISEKEVKDEKNIQEVFDLSDYE--KCEEL 81
K GW+ K +G + + W+ RY +LK D +I KE + + +E L+++ +C+ +
Sbjct: 8 KEGWLHK---RGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREA-PLNNFSVAQCQLM 63
Query: 82 RKSKSRSKKNHSKFTLAHSKQPGNTAPNLIFLAVSPEEKESWINALNSAITRAKNRILDE 141
+ + R T T F +PEE+E W A+ + K + +E
Sbjct: 64 KTERPRPN------TFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEE 117
Query: 142 VTVEEDS 148
+ S
Sbjct: 118 MDFRSGS 124
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 38.5 bits (88), Expect = 0.011
Identities = 30/127 (23%), Positives = 55/127 (43%), Gaps = 12/127 (9%)
Query: 24 KVGWVRKFCGKGIFREIWKNRYVVLKGDQLYISEKEVKDEKNIQEVFDLSDYE--KCEEL 81
K GW+ K +G + + W+ RY +LK D +I KE + + +E L+++ +C+ +
Sbjct: 8 KEGWLHK---RGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREA-PLNNFSVAQCQLM 63
Query: 82 RKSKSRSKKNHSKFTLAHSKQPGNTAPNLIFLAVSPEEKESWINALNSAITRAKNRILDE 141
+ + R T T F +PEE+E W A+ + K + +E
Sbjct: 64 KTERPRPN------TFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEE 117
Query: 142 VTVEEDS 148
+ S
Sbjct: 118 MDFRSGS 124
>gi|22003858 ventricular zone expressed PH domain homolog 1 [Homo
sapiens]
Length = 833
Score = 38.5 bits (88), Expect = 0.011
Identities = 26/107 (24%), Positives = 49/107 (45%), Gaps = 8/107 (7%)
Query: 37 FREIWKNRYVVLKGDQLYISEKEVKDEKNIQEVFDLSDYEKCEELRKSKSRSKKNHSKFT 96
F + WK RY L G+QL + + KD+ + + + +++ K+ +KK + +
Sbjct: 732 FIKRWKTRYFTLAGNQLLFQKGKSKDDPDDCPI-------ELSKVQSVKAVAKKRRDR-S 783
Query: 97 LAHSKQPGNTAPNLIFLAVSPEEKESWINALNSAITRAKNRILDEVT 143
L + + +F A + W+ +N A+ +AK R EVT
Sbjct: 784 LPRAFEIFTDNKTYVFKAKDEKNAAEWLQCINVAVAQAKERESREVT 830
>gi|239745087 PREDICTED: similar to Golgin subfamily A member 8-like
protein 1 isoform 1 [Homo sapiens]
Length = 547
Score = 37.7 bits (86), Expect = 0.019
Identities = 42/194 (21%), Positives = 81/194 (41%), Gaps = 11/194 (5%)
Query: 211 LDKSVAQLAGSRRRADSDRIQPSADRASSLSRPWEKTDKGATYTPQAPKKLTPTEKGRCA 270
L + QL S + +R + + +R W++ + + + KK +K R
Sbjct: 233 LKAQLTQLKESLKEVQLERDEYAEHLKGERAR-WQQRMRKMSQEVCSLKKEKKHDKYRVE 291
Query: 271 SLEEILSQRDAASARTLQLRAEEPPTPALPNPGQLSRIQ---DLVARKLEETQELLAEVQ 327
+LE LS+ A L P PA+P+ +L ++ + VA L+ E +
Sbjct: 292 TLERSLSKLKNQMAEPLP-----PEPPAVPSEAELQHLRKELERVAGALQAQVEYNQRIS 346
Query: 328 GLGDGKRKA--KDPPRSPPDSESEQLLLETERLLGEASSNWSQAKRVLQEVRELRDLYRQ 385
L +G+++ + R P E Q L E + E ++ ++ Q+V+EL++ +
Sbjct: 347 LLNEGQKERLREQQERLPEQEERLQQLAEPQNSFKELNNENKSVLQLEQQVKELQEKLGK 406
Query: 386 MDLQTPDSHLRQTT 399
L+ +Q T
Sbjct: 407 ERLEAASQQKQQLT 420
>gi|239745081 PREDICTED: similar to Golgin subfamily A member 8-like
protein 1 isoform 2 [Homo sapiens]
Length = 629
Score = 37.7 bits (86), Expect = 0.019
Identities = 42/194 (21%), Positives = 81/194 (41%), Gaps = 11/194 (5%)
Query: 211 LDKSVAQLAGSRRRADSDRIQPSADRASSLSRPWEKTDKGATYTPQAPKKLTPTEKGRCA 270
L + QL S + +R + + +R W++ + + + KK +K R
Sbjct: 224 LKAQLTQLKESLKEVQLERDEYAEHLKGERAR-WQQRMRKMSQEVCSLKKEKKHDKYRVE 282
Query: 271 SLEEILSQRDAASARTLQLRAEEPPTPALPNPGQLSRIQ---DLVARKLEETQELLAEVQ 327
+LE LS+ A L P PA+P+ +L ++ + VA L+ E +
Sbjct: 283 TLERSLSKLKNQMAEPLP-----PEPPAVPSEAELQHLRKELERVAGALQAQVEYNQRIS 337
Query: 328 GLGDGKRKA--KDPPRSPPDSESEQLLLETERLLGEASSNWSQAKRVLQEVRELRDLYRQ 385
L +G+++ + R P E Q L E + E ++ ++ Q+V+EL++ +
Sbjct: 338 LLNEGQKERLREQQERLPEQEERLQQLAEPQNSFKELNNENKSVLQLEQQVKELQEKLGK 397
Query: 386 MDLQTPDSHLRQTT 399
L+ +Q T
Sbjct: 398 ERLEAASQQKQQLT 411
>gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]
Length = 1007
Score = 37.7 bits (86), Expect = 0.019
Identities = 65/286 (22%), Positives = 113/286 (39%), Gaps = 42/286 (14%)
Query: 61 KDEKNIQEVFDLSDYEKCEELRKSKSRSKKNHSKFTLAHSKQP--GNTAPNLIFLAVSPE 118
K + I+ V + + K +E +KSKS SK++ S+ SK P + I A SP
Sbjct: 200 KSKGGIEIVKEKTTRSKSKERKKSKSPSKRSKSQDQARKSKSPTLRRRSQEKIGKARSPT 259
Query: 119 EKESWINALNSAITRAKNRILDEVTVEEDSYLAHPTRDRAKIQHSRRP-PTRGHLMAVAS 177
+ + I + + R K+ I++E +R R + + SR P RG S
Sbjct: 260 DDKVKIEDKSKSKDRKKSPIINE------------SRSRDRGKKSRSPVDLRGKSKDRRS 307
Query: 178 TSTSDGMLTLDLIQEEDP--SPEEPTSCAESFRVDLDKSVAQLAGSRRRADSDRIQPSAD 235
S + +E+ P SP + S +G R+ S R S
Sbjct: 308 RSKERKSKRSETDKEKKPIKSPSKDAS----------------SGKENRSPSRRPGRSPK 351
Query: 236 RASSLSRPWEKTDKGATYTPQAPKKLTPTEKGRCASLEEILSQRDAASARTLQLRAEEPP 295
R S +P +K+ + + L + S LS A +R+L+ + EP
Sbjct: 352 RRSLSPKPRDKSRRSRS------PLLNDRRSKQSKSPSRTLSPGRRAKSRSLERKRREPE 405
Query: 296 TPALPNPGQLSRIQDLVARKLEETQELLAEVQGLGDGKRKAKDPPR 341
L +P R D+++R+ E + + + +R+++ P R
Sbjct: 406 RRRLSSPRTRPR-DDILSRR--ERSKDASPINRWSPTRRRSRSPIR 448
>gi|48255891 protein kinase C substrate 80K-H isoform 2 [Homo
sapiens]
Length = 525
Score = 37.4 bits (85), Expect = 0.025
Identities = 24/98 (24%), Positives = 49/98 (50%), Gaps = 4/98 (4%)
Query: 290 RAEEPPTPALPNPGQLSRIQDLVARKLEETQELLAEVQGLGDGKRKAKDPPRSPPDSESE 349
+ E+PP P+ P + ++ EE +E +EVQG + + PP E
Sbjct: 301 KEEQPPVPSSPTEEEEEEEEEEEEEAEEEEEEEDSEVQGEQPKPASPAEEDKMPPYDEQT 360
Query: 350 QLLLETERLLGEASSNWSQAKRVLQEVRE-LRDLYRQM 386
Q ++ + EA + + +A+R L+++ E +R+L +++
Sbjct: 361 QAFIDAAQ---EARNKFEEAERSLKDMEESIRNLEQEI 395
>gi|29788760 diacylglycerol kinase, eta isoform 1 [Homo sapiens]
Length = 1164
Score = 36.2 bits (82), Expect = 0.055
Identities = 30/94 (31%), Positives = 44/94 (46%), Gaps = 17/94 (18%)
Query: 41 WKNRYVVLKGDQLYISEKEVKDEKN-IQEVFDLSDYEKCEELRKSKSRSKKNHSKFTLAH 99
WK RY L+G LY + KD K+ I + DLSD E + +K ++ FT+
Sbjct: 82 WKKRYFKLRGRTLYYA----KDSKSLIFDEVDLSDASVAE------ASTKNANNSFTII- 130
Query: 100 SKQPGNTAPNLIFLAVSPEEKESWINALNSAITR 133
L+ A + +E E WI++L S TR
Sbjct: 131 -----TPFRRLMLCAENRKEMEDWISSLKSVQTR 159
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.127 0.359
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,957,113
Number of Sequences: 37866
Number of extensions: 872674
Number of successful extensions: 3638
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 24
Number of HSP's successfully gapped in prelim test: 201
Number of HSP's that attempted gapping in prelim test: 3482
Number of HSP's gapped (non-prelim): 353
length of query: 409
length of database: 18,247,518
effective HSP length: 105
effective length of query: 304
effective length of database: 14,271,588
effective search space: 4338562752
effective search space used: 4338562752
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.