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Search of human proteins with 20149572
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|20149572 optineurin [Homo sapiens]
(577 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|56549111 optineurin [Homo sapiens] 1118 0.0
gi|56549109 optineurin [Homo sapiens] 1118 0.0
gi|20149572 optineurin [Homo sapiens] 1118 0.0
gi|56549107 optineurin [Homo sapiens] 1118 0.0
gi|223671870 inhibitor of kappa light polypeptide gene enhancer ... 142 8e-34
gi|4504631 inhibitor of kappa light polypeptide gene enhancer in... 142 8e-34
gi|153792133 inhibitor of kappa light polypeptide gene enhancer ... 142 8e-34
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 88 2e-17
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 85 2e-16
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 85 2e-16
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 85 2e-16
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 85 2e-16
gi|71061468 centromere protein E [Homo sapiens] 84 4e-16
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 83 6e-16
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 83 6e-16
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 83 6e-16
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 83 6e-16
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 83 8e-16
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 81 2e-15
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 81 3e-15
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 80 4e-15
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 80 7e-15
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 79 1e-14
gi|14165274 golgi-associated microtubule-binding protein HOOK3 [... 78 2e-14
gi|31982906 cingulin-like 1 [Homo sapiens] 78 3e-14
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 77 3e-14
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 77 3e-14
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 77 3e-14
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 77 4e-14
gi|46592991 GRIP1 associated protein 1 isoform 1 [Homo sapiens] 76 1e-13
>gi|56549111 optineurin [Homo sapiens]
Length = 577
Score = 1118 bits (2893), Expect = 0.0
Identities = 577/577 (100%), Positives = 577/577 (100%)
Query: 1 MSHQPLSCLTEKEDSPSESTGNGPPHLAHPNLDTFTPEELLQQMKELLTENHQLKEAMKL 60
MSHQPLSCLTEKEDSPSESTGNGPPHLAHPNLDTFTPEELLQQMKELLTENHQLKEAMKL
Sbjct: 1 MSHQPLSCLTEKEDSPSESTGNGPPHLAHPNLDTFTPEELLQQMKELLTENHQLKEAMKL 60
Query: 61 NNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSER 120
NNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSER
Sbjct: 61 NNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSER 120
Query: 121 SSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVE 180
SSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVE
Sbjct: 121 SSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVE 180
Query: 181 IRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCL 240
IRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCL
Sbjct: 181 IRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCL 240
Query: 241 REGNQKVERLEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVE 300
REGNQKVERLEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVE
Sbjct: 241 REGNQKVERLEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVE 300
Query: 301 ALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKK 360
ALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKK
Sbjct: 301 ALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKK 360
Query: 361 LELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDR 420
LELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDR
Sbjct: 361 LELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDR 420
Query: 421 AVLKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERA 480
AVLKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERA
Sbjct: 421 AVLKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERA 480
Query: 481 AREKIHEEKEQLALQLAVLLKENDAFEDGGRQSLMEMQSRHGARTSDSDQQAYLVQRGAE 540
AREKIHEEKEQLALQLAVLLKENDAFEDGGRQSLMEMQSRHGARTSDSDQQAYLVQRGAE
Sbjct: 481 AREKIHEEKEQLALQLAVLLKENDAFEDGGRQSLMEMQSRHGARTSDSDQQAYLVQRGAE 540
Query: 541 DRDWRQQRNIPIHSCPKCGEVLPDIDTLQIHVMDCII 577
DRDWRQQRNIPIHSCPKCGEVLPDIDTLQIHVMDCII
Sbjct: 541 DRDWRQQRNIPIHSCPKCGEVLPDIDTLQIHVMDCII 577
>gi|56549109 optineurin [Homo sapiens]
Length = 577
Score = 1118 bits (2893), Expect = 0.0
Identities = 577/577 (100%), Positives = 577/577 (100%)
Query: 1 MSHQPLSCLTEKEDSPSESTGNGPPHLAHPNLDTFTPEELLQQMKELLTENHQLKEAMKL 60
MSHQPLSCLTEKEDSPSESTGNGPPHLAHPNLDTFTPEELLQQMKELLTENHQLKEAMKL
Sbjct: 1 MSHQPLSCLTEKEDSPSESTGNGPPHLAHPNLDTFTPEELLQQMKELLTENHQLKEAMKL 60
Query: 61 NNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSER 120
NNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSER
Sbjct: 61 NNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSER 120
Query: 121 SSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVE 180
SSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVE
Sbjct: 121 SSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVE 180
Query: 181 IRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCL 240
IRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCL
Sbjct: 181 IRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCL 240
Query: 241 REGNQKVERLEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVE 300
REGNQKVERLEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVE
Sbjct: 241 REGNQKVERLEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVE 300
Query: 301 ALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKK 360
ALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKK
Sbjct: 301 ALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKK 360
Query: 361 LELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDR 420
LELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDR
Sbjct: 361 LELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDR 420
Query: 421 AVLKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERA 480
AVLKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERA
Sbjct: 421 AVLKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERA 480
Query: 481 AREKIHEEKEQLALQLAVLLKENDAFEDGGRQSLMEMQSRHGARTSDSDQQAYLVQRGAE 540
AREKIHEEKEQLALQLAVLLKENDAFEDGGRQSLMEMQSRHGARTSDSDQQAYLVQRGAE
Sbjct: 481 AREKIHEEKEQLALQLAVLLKENDAFEDGGRQSLMEMQSRHGARTSDSDQQAYLVQRGAE 540
Query: 541 DRDWRQQRNIPIHSCPKCGEVLPDIDTLQIHVMDCII 577
DRDWRQQRNIPIHSCPKCGEVLPDIDTLQIHVMDCII
Sbjct: 541 DRDWRQQRNIPIHSCPKCGEVLPDIDTLQIHVMDCII 577
>gi|20149572 optineurin [Homo sapiens]
Length = 577
Score = 1118 bits (2893), Expect = 0.0
Identities = 577/577 (100%), Positives = 577/577 (100%)
Query: 1 MSHQPLSCLTEKEDSPSESTGNGPPHLAHPNLDTFTPEELLQQMKELLTENHQLKEAMKL 60
MSHQPLSCLTEKEDSPSESTGNGPPHLAHPNLDTFTPEELLQQMKELLTENHQLKEAMKL
Sbjct: 1 MSHQPLSCLTEKEDSPSESTGNGPPHLAHPNLDTFTPEELLQQMKELLTENHQLKEAMKL 60
Query: 61 NNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSER 120
NNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSER
Sbjct: 61 NNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSER 120
Query: 121 SSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVE 180
SSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVE
Sbjct: 121 SSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVE 180
Query: 181 IRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCL 240
IRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCL
Sbjct: 181 IRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCL 240
Query: 241 REGNQKVERLEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVE 300
REGNQKVERLEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVE
Sbjct: 241 REGNQKVERLEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVE 300
Query: 301 ALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKK 360
ALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKK
Sbjct: 301 ALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKK 360
Query: 361 LELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDR 420
LELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDR
Sbjct: 361 LELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDR 420
Query: 421 AVLKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERA 480
AVLKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERA
Sbjct: 421 AVLKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERA 480
Query: 481 AREKIHEEKEQLALQLAVLLKENDAFEDGGRQSLMEMQSRHGARTSDSDQQAYLVQRGAE 540
AREKIHEEKEQLALQLAVLLKENDAFEDGGRQSLMEMQSRHGARTSDSDQQAYLVQRGAE
Sbjct: 481 AREKIHEEKEQLALQLAVLLKENDAFEDGGRQSLMEMQSRHGARTSDSDQQAYLVQRGAE 540
Query: 541 DRDWRQQRNIPIHSCPKCGEVLPDIDTLQIHVMDCII 577
DRDWRQQRNIPIHSCPKCGEVLPDIDTLQIHVMDCII
Sbjct: 541 DRDWRQQRNIPIHSCPKCGEVLPDIDTLQIHVMDCII 577
>gi|56549107 optineurin [Homo sapiens]
Length = 577
Score = 1118 bits (2893), Expect = 0.0
Identities = 577/577 (100%), Positives = 577/577 (100%)
Query: 1 MSHQPLSCLTEKEDSPSESTGNGPPHLAHPNLDTFTPEELLQQMKELLTENHQLKEAMKL 60
MSHQPLSCLTEKEDSPSESTGNGPPHLAHPNLDTFTPEELLQQMKELLTENHQLKEAMKL
Sbjct: 1 MSHQPLSCLTEKEDSPSESTGNGPPHLAHPNLDTFTPEELLQQMKELLTENHQLKEAMKL 60
Query: 61 NNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSER 120
NNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSER
Sbjct: 61 NNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSER 120
Query: 121 SSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVE 180
SSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVE
Sbjct: 121 SSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVE 180
Query: 181 IRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCL 240
IRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCL
Sbjct: 181 IRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCL 240
Query: 241 REGNQKVERLEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVE 300
REGNQKVERLEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVE
Sbjct: 241 REGNQKVERLEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVE 300
Query: 301 ALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKK 360
ALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKK
Sbjct: 301 ALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKK 360
Query: 361 LELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDR 420
LELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDR
Sbjct: 361 LELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDR 420
Query: 421 AVLKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERA 480
AVLKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERA
Sbjct: 421 AVLKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERA 480
Query: 481 AREKIHEEKEQLALQLAVLLKENDAFEDGGRQSLMEMQSRHGARTSDSDQQAYLVQRGAE 540
AREKIHEEKEQLALQLAVLLKENDAFEDGGRQSLMEMQSRHGARTSDSDQQAYLVQRGAE
Sbjct: 481 AREKIHEEKEQLALQLAVLLKENDAFEDGGRQSLMEMQSRHGARTSDSDQQAYLVQRGAE 540
Query: 541 DRDWRQQRNIPIHSCPKCGEVLPDIDTLQIHVMDCII 577
DRDWRQQRNIPIHSCPKCGEVLPDIDTLQIHVMDCII
Sbjct: 541 DRDWRQQRNIPIHSCPKCGEVLPDIDTLQIHVMDCII 577
>gi|223671870 inhibitor of kappa light polypeptide gene enhancer in
B-cells, kinase gamma isoform b [Homo sapiens]
Length = 487
Score = 142 bits (358), Expect = 8e-34
Identities = 103/339 (30%), Positives = 186/339 (54%), Gaps = 15/339 (4%)
Query: 245 QKVERLEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNL 304
++ E L +EA++ V E+ + +++ Q E + + ++ + + + ++
Sbjct: 156 EEKEFLMCKFQEARKLV---ERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKA 212
Query: 305 QVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELN--EKQELVYTNKKLE 362
QVTSL ELQE+ ++L A + L+ + +A + + SE ++Q V ++ L
Sbjct: 213 QVTSLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQ-LR 271
Query: 363 LQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAV 422
+Q +S+ + ++ME+ +EK KL LQ+ +++L QE++N +K+ + SE+
Sbjct: 272 MQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKS----SVVGSERKRGMQ 327
Query: 423 LKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERAAR 482
L++L ++L+ AE+AL +KQ +D++K+ + + +ET+ +L+AQ ++Y +DF AER AR
Sbjct: 328 LEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAR 387
Query: 483 EKIHEEKEQLALQLAVLLKENDAFEDGGRQS--LMEMQSRH--GARTSDSDQQAYLVQRG 538
EK+ E+KE L QL L +E + ++S + +M+ RH ++ AYL
Sbjct: 388 EKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQAPLPPAPAYLSSPL 447
Query: 539 AEDRDWRQ-QRNIPIHSCPKCGEVLPDIDTLQIHVMDCI 576
A R P CPKC PD+DTLQIHVM+CI
Sbjct: 448 ALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQIHVMECI 486
Score = 67.0 bits (162), Expect = 4e-11
Identities = 109/465 (23%), Positives = 188/465 (40%), Gaps = 72/465 (15%)
Query: 4 QPLSCLTEKEDSPSESTGNGPPHLAHPNLDTFTPEELLQQMKELLTENHQLKEAMKLNNQ 63
QP +D E + G P + H + PE L + L EN +L++A++ +NQ
Sbjct: 83 QPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETL----QRCLEENQELRDAIRQSNQ 138
Query: 64 AMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSERSSE 123
++ R EEL + Q+EE++F LM E KL E LG K +R E
Sbjct: 139 ILRERCEELLHFQASQREEKEF-----------LMCKFQEARKLVERLGLEKLDLKRQKE 187
Query: 124 DPTDD-SRLPRAEAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIR 182
+ L R + + +D+ ++A+ LLG + E Q +L E + E +
Sbjct: 188 QALREVEHLKRCQQQMAEDK-----ASVKAQVTSLLGELQESQSRL------EAATKECQ 236
Query: 183 MAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLRE 242
EG A + ++ + + S AL + S D LR
Sbjct: 237 ALEGRARAASEQAR------QLESEREALQQQHSVQVDQ------------------LRM 272
Query: 243 GNQKVERLEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEAL 302
Q V E AL+ ++ S+ ++K + Q +E D VGSE
Sbjct: 273 QGQSV---EAALRMERQAASEEKRKLAQLQVAYHQ----LFQEYDNHIKSSVVGSE-RKR 324
Query: 303 NLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLE 362
+Q+ L ++LQ+A L + + +L+E+ + + +P L + ++ + + E
Sbjct: 325 GMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVP-VLKAQADIYKADFQAE 383
Query: 363 LQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAV 422
Q L+E K E + +L LQ ++KL + + IE++ RK +V +A
Sbjct: 384 RQAREKLAE------KKELLQEQLEQLQREYSKLKASCQESAR-IEDM-RKRHVEVSQAP 435
Query: 423 LKE----LSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTI 463
L LS L L + + + D Q D++T+ I
Sbjct: 436 LPPAPAYLSSPLALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQI 480
>gi|4504631 inhibitor of kappa light polypeptide gene enhancer in
B-cells, kinase gamma isoform a [Homo sapiens]
Length = 419
Score = 142 bits (358), Expect = 8e-34
Identities = 103/339 (30%), Positives = 186/339 (54%), Gaps = 15/339 (4%)
Query: 245 QKVERLEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNL 304
++ E L +EA++ V E+ + +++ Q E + + ++ + + + ++
Sbjct: 88 EEKEFLMCKFQEARKLV---ERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKA 144
Query: 305 QVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELN--EKQELVYTNKKLE 362
QVTSL ELQE+ ++L A + L+ + +A + + SE ++Q V ++ L
Sbjct: 145 QVTSLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQ-LR 203
Query: 363 LQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAV 422
+Q +S+ + ++ME+ +EK KL LQ+ +++L QE++N +K+ + SE+
Sbjct: 204 MQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKS----SVVGSERKRGMQ 259
Query: 423 LKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERAAR 482
L++L ++L+ AE+AL +KQ +D++K+ + + +ET+ +L+AQ ++Y +DF AER AR
Sbjct: 260 LEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAR 319
Query: 483 EKIHEEKEQLALQLAVLLKENDAFEDGGRQS--LMEMQSRH--GARTSDSDQQAYLVQRG 538
EK+ E+KE L QL L +E + ++S + +M+ RH ++ AYL
Sbjct: 320 EKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQAPLPPAPAYLSSPL 379
Query: 539 AEDRDWRQ-QRNIPIHSCPKCGEVLPDIDTLQIHVMDCI 576
A R P CPKC PD+DTLQIHVM+CI
Sbjct: 380 ALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQIHVMECI 418
Score = 67.0 bits (162), Expect = 4e-11
Identities = 109/465 (23%), Positives = 188/465 (40%), Gaps = 72/465 (15%)
Query: 4 QPLSCLTEKEDSPSESTGNGPPHLAHPNLDTFTPEELLQQMKELLTENHQLKEAMKLNNQ 63
QP +D E + G P + H + PE L + L EN +L++A++ +NQ
Sbjct: 15 QPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETL----QRCLEENQELRDAIRQSNQ 70
Query: 64 AMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSERSSE 123
++ R EEL + Q+EE++F LM E KL E LG K +R E
Sbjct: 71 ILRERCEELLHFQASQREEKEF-----------LMCKFQEARKLVERLGLEKLDLKRQKE 119
Query: 124 DPTDD-SRLPRAEAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIR 182
+ L R + + +D+ ++A+ LLG + E Q +L E + E +
Sbjct: 120 QALREVEHLKRCQQQMAEDK-----ASVKAQVTSLLGELQESQSRL------EAATKECQ 168
Query: 183 MAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLRE 242
EG A + ++ + + S AL + S D LR
Sbjct: 169 ALEGRARAASEQAR------QLESEREALQQQHSVQVDQ------------------LRM 204
Query: 243 GNQKVERLEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEAL 302
Q V E AL+ ++ S+ ++K + Q +E D VGSE
Sbjct: 205 QGQSV---EAALRMERQAASEEKRKLAQLQVAYHQ----LFQEYDNHIKSSVVGSE-RKR 256
Query: 303 NLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLE 362
+Q+ L ++LQ+A L + + +L+E+ + + +P L + ++ + + E
Sbjct: 257 GMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVP-VLKAQADIYKADFQAE 315
Query: 363 LQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAV 422
Q L+E K E + +L LQ ++KL + + IE++ RK +V +A
Sbjct: 316 RQAREKLAE------KKELLQEQLEQLQREYSKLKASCQESAR-IEDM-RKRHVEVSQAP 367
Query: 423 LKE----LSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTI 463
L LS L L + + + D Q D++T+ I
Sbjct: 368 LPPAPAYLSSPLALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQI 412
>gi|153792133 inhibitor of kappa light polypeptide gene enhancer in
B-cells, kinase gamma isoform a [Homo sapiens]
Length = 419
Score = 142 bits (358), Expect = 8e-34
Identities = 103/339 (30%), Positives = 186/339 (54%), Gaps = 15/339 (4%)
Query: 245 QKVERLEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNL 304
++ E L +EA++ V E+ + +++ Q E + + ++ + + + ++
Sbjct: 88 EEKEFLMCKFQEARKLV---ERLGLEKLDLKRQKEQALREVEHLKRCQQQMAEDKASVKA 144
Query: 305 QVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELN--EKQELVYTNKKLE 362
QVTSL ELQE+ ++L A + L+ + +A + + SE ++Q V ++ L
Sbjct: 145 QVTSLLGELQESQSRLEAATKECQALEGRARAASEQARQLESEREALQQQHSVQVDQ-LR 203
Query: 363 LQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAV 422
+Q +S+ + ++ME+ +EK KL LQ+ +++L QE++N +K+ + SE+
Sbjct: 204 MQGQSVEAALRMERQAASEEKRKLAQLQVAYHQLFQEYDNHIKS----SVVGSERKRGMQ 259
Query: 423 LKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERAAR 482
L++L ++L+ AE+AL +KQ +D++K+ + + +ET+ +L+AQ ++Y +DF AER AR
Sbjct: 260 LEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVPVLKAQADIYKADFQAERQAR 319
Query: 483 EKIHEEKEQLALQLAVLLKENDAFEDGGRQS--LMEMQSRH--GARTSDSDQQAYLVQRG 538
EK+ E+KE L QL L +E + ++S + +M+ RH ++ AYL
Sbjct: 320 EKLAEKKELLQEQLEQLQREYSKLKASCQESARIEDMRKRHVEVSQAPLPPAPAYLSSPL 379
Query: 539 AEDRDWRQ-QRNIPIHSCPKCGEVLPDIDTLQIHVMDCI 576
A R P CPKC PD+DTLQIHVM+CI
Sbjct: 380 ALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQIHVMECI 418
Score = 67.0 bits (162), Expect = 4e-11
Identities = 109/465 (23%), Positives = 188/465 (40%), Gaps = 72/465 (15%)
Query: 4 QPLSCLTEKEDSPSESTGNGPPHLAHPNLDTFTPEELLQQMKELLTENHQLKEAMKLNNQ 63
QP +D E + G P + H + PE L + L EN +L++A++ +NQ
Sbjct: 15 QPSGGPAADQDVLGEESPLGKPAMLHLPSEQGAPETL----QRCLEENQELRDAIRQSNQ 70
Query: 64 AMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSERSSE 123
++ R EEL + Q+EE++F LM E KL E LG K +R E
Sbjct: 71 ILRERCEELLHFQASQREEKEF-----------LMCKFQEARKLVERLGLEKLDLKRQKE 119
Query: 124 DPTDD-SRLPRAEAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIR 182
+ L R + + +D+ ++A+ LLG + E Q +L E + E +
Sbjct: 120 QALREVEHLKRCQQQMAEDK-----ASVKAQVTSLLGELQESQSRL------EAATKECQ 168
Query: 183 MAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLRE 242
EG A + ++ + + S AL + S D LR
Sbjct: 169 ALEGRARAASEQAR------QLESEREALQQQHSVQVDQ------------------LRM 204
Query: 243 GNQKVERLEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEAL 302
Q V E AL+ ++ S+ ++K + Q +E D VGSE
Sbjct: 205 QGQSV---EAALRMERQAASEEKRKLAQLQVAYHQ----LFQEYDNHIKSSVVGSE-RKR 256
Query: 303 NLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLE 362
+Q+ L ++LQ+A L + + +L+E+ + + +P L + ++ + + E
Sbjct: 257 GMQLEDLKQQLQQAEEALVAKQEVIDKLKEEAEQHKIVMETVP-VLKAQADIYKADFQAE 315
Query: 363 LQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAV 422
Q L+E K E + +L LQ ++KL + + IE++ RK +V +A
Sbjct: 316 RQAREKLAE------KKELLQEQLEQLQREYSKLKASCQESAR-IEDM-RKRHVEVSQAP 367
Query: 423 LKE----LSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTI 463
L LS L L + + + D Q D++T+ I
Sbjct: 368 LPPAPAYLSSPLALPSQRRSPPEEPPDFCCPKCQYQAPDMDTLQI 412
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 88.2 bits (217), Expect = 2e-17
Identities = 104/483 (21%), Positives = 213/483 (44%), Gaps = 35/483 (7%)
Query: 38 EELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQK----------EERQFFE 87
+ L +Q KEL + +L+E +L Q + + +E W +++K +E + +E
Sbjct: 321 KRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWE 380
Query: 88 IQSKEAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQV 147
Q K+ +E+ + + E++ E+ +L+ K ER E ++ + E++K Q + +
Sbjct: 381 -QEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMR-EEKKMQEQEKK 438
Query: 148 VRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVST 207
R Q EK + E + K+ E++ E + E ++ E + + +
Sbjct: 439 TRDQEEKMQEEERIREREKKMREE---EETMREQEEKMQKQEENMWEQEEKEWQQQRLPE 495
Query: 208 GTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGN----QKVERLEVALKEAKERVSD 263
+ + + + +E EE Q + +E +K+ E + E +E++ D
Sbjct: 496 QKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRD 555
Query: 264 FEKKT---SNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKE----LQEA 316
E+K R E +TQ + + +E+ E E E + + +E +QE
Sbjct: 556 QEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQ 615
Query: 317 HTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKM-E 375
K+ E E +EK Q E K ++ E++E ++ ++L Q E + KM E
Sbjct: 616 EEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQE 675
Query: 376 QAKTEDEKSKLTVLQMTHNKLLQEHNNAL---KTIEELTRKESEK---VDRAVLKELSEK 429
Q K ++++ K+ + K ++ K EE + +E EK + +++E EK
Sbjct: 676 QEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEK 735
Query: 430 LELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERAAREKIHEEK 489
++ E+ + ++ +M E ++ + +QEE + L Q E H + +EKI E++
Sbjct: 736 MQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWE--HEKMQEQEKIWEQE 793
Query: 490 EQL 492
E++
Sbjct: 794 EKM 796
Score = 73.9 bits (180), Expect = 4e-13
Identities = 97/481 (20%), Positives = 201/481 (41%), Gaps = 75/481 (15%)
Query: 72 LSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRL 131
LSA + + K+ ++ E +KE ++ L + N EEL K + + +L
Sbjct: 185 LSAVSTRHKKADRYIEELTKE-RDALSLELYRNTITNEELKKKNAELQE---------KL 234
Query: 132 PRAEAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGS 191
P AE+E+ + QL + ++ + E+A L V+ + E
Sbjct: 235 PLAESEKSEIQLNVKELKRKLERAKFL-----------------LPQVQTNTLQEEMWRQ 277
Query: 192 VKEIKHSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLE 251
+E++ R + R R +G +RE +K+ R E
Sbjct: 278 EEELREQEKKIRKQEEKMWRQEERLREQEGK-----------------MREQEEKMWRQE 320
Query: 252 VALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFK 311
L+E ++ + + EK+ + E+ Q E E+E E + + E + Q +++
Sbjct: 321 KRLREQEKELREQEKELREQKELREQEEQMQEQE-------EKMWEQEEKMREQEEKMWR 373
Query: 312 ELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSE 371
+ +L E E + ++K + E + L EK+E + +K+ QVE M E
Sbjct: 374 Q----EERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREE 429
Query: 372 IKM--EQAKTEDEKSKLTVLQ--MTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELS 427
KM ++ KT D++ K+ + K ++E ++ EE +K+ E + KE
Sbjct: 430 KKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQ 489
Query: 428 EKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERAAREKIHE 487
++ +K +Q +M E ++ I +QEE +R Q E++ + R +EK+ E
Sbjct: 490 QQRLPEQKEKLWEQEKMQEQEEKIWEQEEK------IRDQEEMWGQEKKMWR--QEKMRE 541
Query: 488 EKEQLALQLAVLLKENDAFEDGGRQSLMEMQSRHGARTSDSDQQAYLVQRGAEDRDWRQQ 547
+++Q + ++ + D Q + + + R +T + +++ + + + + ++
Sbjct: 542 QEDQ-------MWEQEEKMRD-QEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMRE 593
Query: 548 R 548
R
Sbjct: 594 R 594
Score = 70.5 bits (171), Expect = 4e-12
Identities = 90/459 (19%), Positives = 198/459 (43%), Gaps = 39/459 (8%)
Query: 40 LLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMA 99
LL Q++ + ++ +L Q K R +E W ++++ Q +++ +E K
Sbjct: 261 LLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEK----- 315
Query: 100 LSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADLLG 159
+ + ++L+E+ +L+ + + E + + + ++EK + + +R Q EK
Sbjct: 316 MWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKM---- 371
Query: 160 IVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSRSA 219
E R+ E E + +E K R L + R
Sbjct: 372 -----------------WRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMR 414
Query: 220 DGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEKKTSNRSEIETQTE 279
+ K + + E++ + ++E +K E ++E +ER+ + EKK E + E
Sbjct: 415 EQEKMWEQVEKMREEKK---MQEQEKKTRDQEEKMQE-EERIREREKKMREEEETMREQE 470
Query: 280 GSTEKENDEEKGPETVGSEVEALNLQVTSLFKE--LQEAHTKLSEAELMKKRLQEKCQAL 337
+K+ + E + + L Q L+++ +QE K+ E E K R QE+
Sbjct: 471 EKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQE-EKIRDQEEMWGQ 529
Query: 338 ERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQAKTEDEKSKL--TVLQMTHNK 395
E+K ++ ++ +K+ Q + M + + + KT++++ K +M +
Sbjct: 530 EKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEE 589
Query: 396 LLQEHNNALKTIEELTRKESEKV--DRAVLKELSEKLELAEKALASKQLQMDEMKQTIAK 453
++E ++ EE+ R++ EK+ ++E EK+ E+ + ++ +M E ++ + +
Sbjct: 590 RMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWE 649
Query: 454 QEEDLETMTILRAQMEVYCSDFHAERAAREKIHEEKEQL 492
QEE + L Q E H + +EK+ E++E++
Sbjct: 650 QEEKMWEQQRLPEQKEKLWE--HEKMQEQEKMQEQEEKI 686
Score = 62.0 bits (149), Expect = 1e-09
Identities = 94/452 (20%), Positives = 189/452 (41%), Gaps = 48/452 (10%)
Query: 38 EELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERL 97
E + +Q + L + +++E K+ Q K R E+ EK+ +++ + + +ER
Sbjct: 397 ERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIRERE 456
Query: 98 MALSHENEKLKEELGKLKGKSER---SSEDPTDDSRLPRAEA---EQEKDQLRTQVVRLQ 151
+ E E ++E+ K++ + E E RLP + EQEK Q + + + Q
Sbjct: 457 KKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQ 516
Query: 152 AEKA----DLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSV---KEIKHSPGPTRT 204
EK ++ G ++ + ED E + E + +E +
Sbjct: 517 EEKIRDQEEMWGQEKKMW-RQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQE 575
Query: 205 VSTGTALSKYRS--RSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVS 262
T K R R + K E EE+ +RE +K++ E ++E +E++
Sbjct: 576 KKTWDQEEKMREEERMREREKKMREEEEM--------MREQEEKMQEQEEKMQEQEEKMW 627
Query: 263 DFEKKTSNRSE-IETQTEGSTEKEN---DEEKGPETVGSEVEALNLQVTSLFKELQEAHT 318
+ E+K + E + Q E E+E ++++ PE E +Q +++QE
Sbjct: 628 EQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQ---EKMQEQEE 684
Query: 319 KLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLS-------- 370
K+ E E M+K+ QE + K + ++ E++ + KK+ + E M
Sbjct: 685 KIWEQEKMEKKTQE-----QEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQ 739
Query: 371 EIKMEQAK----TEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKEL 426
E KM++ + ++EK +M + L E L E++ +E +++
Sbjct: 740 EEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQ 799
Query: 427 SEKLELAEKALASKQLQMDEMKQTIAKQEEDL 458
EK+ E+ + ++ +M ++ + QEE +
Sbjct: 800 EEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKM 831
Score = 46.6 bits (109), Expect = 6e-05
Identities = 74/357 (20%), Positives = 132/357 (36%), Gaps = 60/357 (16%)
Query: 254 LKEAKERVSDF----------------EKKTSNRSEIETQTEGSTEKENDEEKGPETVGS 297
L EAK++ +D+ +KK ++ + ET T G D ++ +
Sbjct: 22 LAEAKKKFTDYRQWNIAGVGTGATDTKKKKINHGTNPETTTSGGCHSPEDTQQNRAQLKE 81
Query: 298 EVEALNLQVTSLFKELQ-EAHT------KLSEAELMKKRLQEKCQALERKNSAIPSELNE 350
E +A + +L +E++ + HT + +E E Q+ + E N PS N
Sbjct: 82 EKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDGNLGTPSSFNL 141
Query: 351 KQELVYTNKKLELQVESML-SEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEE 409
+ L S++ E K + LQ + + H A + IEE
Sbjct: 142 ALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRALSAVSTRHKKADRYIEE 201
Query: 410 LTRKES--------EKVDRAVLK----ELSEKLELAEKALASKQLQMDEMKQTIA----- 452
LT++ + LK EL EKL LAE + QL + E+K+ +
Sbjct: 202 LTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFL 261
Query: 453 --------------KQEEDL-ETMTILRAQMEVYCSDFHAERAAREKIHEEKEQLALQLA 497
+QEE+L E +R Q E R K+ E++E++ Q
Sbjct: 262 LPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEK 321
Query: 498 VLLKENDAFEDGGRQSLMEMQSRHGARTSDSDQQAYLVQ----RGAEDRDWRQQRNI 550
L ++ + ++ + + R ++ Q R E++ WRQ+ +
Sbjct: 322 RLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERL 378
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 85.1 bits (209), Expect = 2e-16
Identities = 101/466 (21%), Positives = 197/466 (42%), Gaps = 41/466 (8%)
Query: 87 EIQSKEAK--ERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLR 144
E++ K AK E+L + E +++ + +LK K ER+ LP+ + + E D L
Sbjct: 218 ELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAK------LLLPQQQLQAEADHLG 271
Query: 145 TQVVRLQAEKADLLGIVSELQL--KLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPT 202
+ LQ+ A L V E +L +LN + E ++ E E + +E K
Sbjct: 272 KE---LQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEE 328
Query: 203 RTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVS 262
+ + + + + EE+ + E +K+ RLE + E +E++
Sbjct: 329 KIREQEEKMRRQEEMMWEKEEKMRRQEEM--------MWEKEEKMRRLEEMMWEKEEKIR 380
Query: 263 DFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSE 322
+ E+K + +I Q E E+E E+ E EA + +E +E K+ E
Sbjct: 381 ELEEKMHEQEKIREQEEKRQEEEKIREQEKR---QEQEAKMWRQEEKIREQEE---KIRE 434
Query: 323 AELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKM-EQAKTED 381
E R +EK E+ + E++E+ +K+ Q E + KM EQ K
Sbjct: 435 QEKKMWRQEEKIHEQEKIREE--EKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRK 492
Query: 382 EKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKLELAEKALASKQ 441
++ K+ + + + ++ EE ++ EK+ +E EK+ E+ + ++
Sbjct: 493 QEEKV----WRQEEKMHDQEEKIREQEEKMWRQEEKI-----REQEEKIREQEEKIREQE 543
Query: 442 LQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAVLLK 501
M E ++ + +QEE ++ +R Q E R +EKI E++E++ Q + +
Sbjct: 544 EMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIRE 603
Query: 502 ENDAFEDGGRQSLMEMQSRHGARTSDSDQQAYLVQRGAEDRDWRQQ 547
+ + ++ ++ M Q + Q+ R E++ W Q+
Sbjct: 604 QEEMMQE--QEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQE 647
Score = 65.5 bits (158), Expect = 1e-10
Identities = 84/460 (18%), Positives = 195/460 (42%), Gaps = 56/460 (12%)
Query: 39 ELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLM 98
+LL ++L E L + ++ + ++ + EE W +++ + Q ++ +E
Sbjct: 255 KLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEE 314
Query: 99 ALSHENEKLKEELGKLKGKSE---RSSEDPTDDSRLPRAEAEQ--EKDQLRTQVVRLQAE 153
+ + EK++E+ K++ + E R E + R + E EK++ ++ + E
Sbjct: 315 KIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWE 374
Query: 154 KADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSK 213
K + + EL+ K++ +IR E + + K + +
Sbjct: 375 KEEK---IRELEEKMHEQ-------EKIREQEEKRQEEEK-----------------IRE 407
Query: 214 YRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEKKTSNRSE 273
R AK + + E+ +RE +K+ E + +E++ + EK R E
Sbjct: 408 QEKRQEQEAKMWRQEEK---------IREQEEKIREQEKKMWRQEEKIHEQEK---IREE 455
Query: 274 IETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAELMKKRLQEK 333
+ Q + ++ ++ + E + + E ++ Q +++++ K+ E +EK
Sbjct: 456 EKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQ-----EKIRKQEEKVWRQEEKMHDQEEK 510
Query: 334 CQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQAKTEDEKSKLTVLQMTH 393
+ E K ++ E++E + ++ + E M+ E + + + E++ + ++
Sbjct: 511 IREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQE 570
Query: 394 NKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKLELAEKALASKQLQMDEMKQTIAK 453
K ++E ++ +E R++ EK+ E EK+ E+ + ++ +M E ++ + +
Sbjct: 571 EK-IREQEEKIREQKEKIREQEEKI-----WEQEEKIREQEEMMQEQEEKMWEQEEKMCE 624
Query: 454 QEEDL-ETMTILRAQMEVYCSDFHAERAAREKIHEEKEQL 492
QEE + E +R Q E R EK+ E +E L
Sbjct: 625 QEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHL 664
Score = 50.4 bits (119), Expect = 4e-06
Identities = 85/378 (22%), Positives = 151/378 (39%), Gaps = 81/378 (21%)
Query: 248 ERLEVALKEAKERVSDF----------------EKKTSNRSEIETQTEGSTEKENDEEKG 291
E + L EAKE+++D +KK +N + ET T G DE+K
Sbjct: 54 ETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGCHSPEDEQKA 113
Query: 292 ----PETVGSEVEA-------LNLQVTSL----------FKELQ---------------- 314
E + E+EA L Q T L K+L+
Sbjct: 114 SHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKF 173
Query: 315 --EAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEK----QELVYTNKKLELQ---V 365
E LS KK+ + L ++ A+ EL +EL N KL+ + V
Sbjct: 174 AGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLV 233
Query: 366 ESMLSEIKM--EQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVL 423
ES SEI++ ++ K + E++KL + Q +L E ++ K ++ ++ K +V+ L
Sbjct: 234 ESEKSEIQLNVKELKRKLERAKLLLPQ---QQLQAEADHLGKELQSVSAKLQAQVEENEL 290
Query: 424 -----KELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAE 478
++ EK+ E+ + + ++ E ++ I +QEE + + E + +
Sbjct: 291 WNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEK 350
Query: 479 RAAREKIHEEKEQLALQLAVLLKENDAFEDGGRQSLMEMQSRHGARTSDSDQQAYLVQRG 538
+E++ EKE+ +L ++ E E+ R+ +M + R + +Q R
Sbjct: 351 MRRQEEMMWEKEEKMRRLEEMMWEK---EEKIRELEEKMHEQEKIREQEEKRQEEEKIRE 407
Query: 539 AEDRD------WRQQRNI 550
E R WRQ+ I
Sbjct: 408 QEKRQEQEAKMWRQEEKI 425
Score = 41.2 bits (95), Expect = 0.003
Identities = 45/256 (17%), Positives = 108/256 (42%), Gaps = 26/256 (10%)
Query: 38 EELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERL 97
E++ +Q K++ + ++ E K+ + + EE+ EK +E+ + + + K
Sbjct: 430 EKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEK------ 483
Query: 98 MALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADL 157
HE EK++++ K+ + E D + R + ++++++R Q +++ ++ +
Sbjct: 484 ---MHEQEKIRKQEEKV-WRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKI 539
Query: 158 LGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSR 217
+Q + G E+ E + E ++E + + + + +
Sbjct: 540 REQEEMMQEQEEKMGEQEEKMQEQEKMRRQEE-KIREQEEK------------IREQKEK 586
Query: 218 SADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEKKTSNRSEIETQ 277
+ + +E EE Q + ++E +K+ E + E +E++ + E+K R + E
Sbjct: 587 IREQEEKIWEQEEKIREQEEM-MQEQEEKMWEQEEKMCEQEEKMQEQEEKM--RRQEEKM 643
Query: 278 TEGSTEKENDEEKGPE 293
E EEK E
Sbjct: 644 WEQEVRLRQQEEKMQE 659
Score = 38.5 bits (88), Expect = 0.017
Identities = 29/123 (23%), Positives = 60/123 (48%), Gaps = 4/123 (3%)
Query: 38 EELLQQMKELLTENH---QLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAK 94
EE++Q+ +E + E Q +E M+ + ++ + E++ EK +E+ + Q ++ +
Sbjct: 543 EEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIR 602
Query: 95 ERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEK 154
E+ + + EK+ E+ K+ + E+ E R EQE +LR Q ++Q +
Sbjct: 603 EQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEV-RLRQQEEKMQEHQ 661
Query: 155 ADL 157
L
Sbjct: 662 EHL 664
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 85.1 bits (209), Expect = 2e-16
Identities = 110/518 (21%), Positives = 226/518 (43%), Gaps = 52/518 (10%)
Query: 39 ELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSA-----WTEKQKEER-------QFF 86
+ L ++ E L + + K A + A++ EL A T +Q+ E+ Q
Sbjct: 1228 QALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQ 1287
Query: 87 EIQSK---------EAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAE 137
E+Q + EA E+L E E + L + + K+ R S++ + E
Sbjct: 1288 EVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQE 1347
Query: 138 QEKDQLRTQVV---RLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKE 194
+++ R ++ R++A +A+ G+ +L+ + + E + E++ A+ + +
Sbjct: 1348 LLQEETRAKLALGSRVRAMEAEAAGLREQLE---EEAAARERAGRELQTAQAQLSEWRRR 1404
Query: 195 IKHSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVAL 254
+ G + G + +R A+ + TV +L R Q+++ + L
Sbjct: 1405 QEEEAG---ALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDL 1461
Query: 255 KEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQ 314
++ ++ VS EKK ++ + + + + +E + E G E EA L +T +E Q
Sbjct: 1462 EQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQ 1521
Query: 315 EAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKM 374
EA +L E + L+ + +AL + ++E + ++ + + ++E++
Sbjct: 1522 EAREEL---ERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELED 1578
Query: 375 EQAKTEDEKSKLTV----LQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKL 430
E ED K +L V L+ H + LQ + A EE R+ ++++ A ++ E+
Sbjct: 1579 ELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAG---EERRRQLAKQLRDAEVERDEERK 1635
Query: 431 ELAEKALASKQLQ--MDEMKQTIAK----QEEDLETMTILRAQMEVYCSDFHAERAAREK 484
+ A K+L+ ++E+K +A +EE ++ + ++AQM+ + R +RE+
Sbjct: 1636 QRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREE 1695
Query: 485 I-----HEEKEQLALQLAVL-LKENDAFEDGGRQSLME 516
I EK L+ VL L+E A D R+ +
Sbjct: 1696 IFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQ 1733
Score = 69.3 bits (168), Expect = 9e-12
Identities = 115/543 (21%), Positives = 208/543 (38%), Gaps = 95/543 (17%)
Query: 38 EELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERL 97
+E L+ + T+ + + + +A++G E+ T Q+E R E + E K+ L
Sbjct: 1149 QEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTL 1208
Query: 98 MALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADL 157
+ +E +EL + G++ + + +R + E+ + L +V L+AE + L
Sbjct: 1209 EEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSL 1268
Query: 158 LGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSR 217
+ EGE E++ L + + R
Sbjct: 1269 ----------------------QTARQEGEQRRRRLELQ--------------LQEVQGR 1292
Query: 218 SADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEKKTSNRSEIETQ 277
+ DG + E E L+ ++E + AL EA+ + K+ S+ E Q
Sbjct: 1293 AGDGERARAEAAEK--------LQRAQAELENVSGALNEAESKTIRLSKELSS---TEAQ 1341
Query: 278 TEGSTEKENDEEKGPETVGSEVEALNLQVTSL--------------FKELQEAHTKLSEA 323
+ E +E + +GS V A+ + L +ELQ A +LSE
Sbjct: 1342 LHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSE- 1400
Query: 324 ELMKKRLQEKCQALE----------RKNSAIPSELNEKQELVYTNKKLELQVESMLSEIK 373
++R +E+ ALE R+ A+ L EK E V ++ +++ L +
Sbjct: 1401 --WRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDAT 1458
Query: 374 MEQAKTEDEKSKLTVLQMTHNKLLQEHNNA-LKTIEELTRKESEKVDRAVL--------- 423
M+ + S L Q ++LL E A L+ +EE R E+E +R
Sbjct: 1459 MDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALE 1518
Query: 424 --KELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLE--------TMTILRAQMEVYCS 473
+E E+LE +AL ++ + K + K +LE LRAQ+
Sbjct: 1519 EEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELED 1578
Query: 474 DFHAERAAREKIHEEKEQLALQLAVLLKEND-AFEDGGRQSLMEMQSRHGARTSDSDQQA 532
+ A A+ ++ + L Q L+ D A E+ RQ +++ R + Q+
Sbjct: 1579 ELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRT 1638
Query: 533 YLV 535
V
Sbjct: 1639 LAV 1641
Score = 65.5 bits (158), Expect = 1e-10
Identities = 116/529 (21%), Positives = 211/529 (39%), Gaps = 81/529 (15%)
Query: 32 LDTFTPEELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEE-------RQ 84
L+ T E +++ +E L + + ++ R E S+ +++E+ R
Sbjct: 996 LEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRL 1055
Query: 85 FFEIQSKEAKERLMALSHENEKLKEELGKLK----GKSERSSEDPTDDSRLP---RAEAE 137
+E + ++RL + EK ++EL KLK G+S E + + RA+
Sbjct: 1056 KYEATIADMEDRL----RKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLG 1111
Query: 138 QEKDQLRTQVVRLQAE---KADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKE 194
+++++L+ + R + E +A LL + E Q L +++ R+A +AE ++
Sbjct: 1112 RKEEELQAALARAEDEGGARAQLLKSLREAQAAL---AEAQEDLESERVARTKAEKQRRD 1168
Query: 195 IKHSPGPTR-----TVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVER 249
+ R T+ + A + RS+ E V++L L E +
Sbjct: 1169 LGEELEALRGELEDTLDSTNAQQELRSK-----------REQEVTELKKTLEE---ETRI 1214
Query: 250 LEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSL 309
E A++E ++R + + + E + +G+ EK AL +V+ L
Sbjct: 1215 HEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTR-------------LALEAEVSEL 1261
Query: 310 FKELQEAHTKLSEAELMKKRLQEKCQALE-RKNSAIPSELNEKQELVYTNKKLELQVESM 368
EL T E E ++RL+ + Q ++ R + ++L +LE V
Sbjct: 1262 RAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELE-NVSGA 1320
Query: 369 LSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTR-KESEKVD-RAVLKEL 426
L+E + + + E S +LLQE A + R E+E R L+E
Sbjct: 1321 LNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEE 1380
Query: 427 SEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERAAREKIH 486
+ E A + L + Q Q+ E ++ +QEE+ + A AR +
Sbjct: 1381 AAARERAGRELQTAQAQLSEWRR---RQEEEAGAL--------------EAGEEARRRAA 1423
Query: 487 EEKEQLALQLAVLLKENDAFEDGGRQSLMEMQSRHGARTSDSDQQAYLV 535
E E L +LA + D E G R+ E+ T D +QQ LV
Sbjct: 1424 REAEALTQRLAEKTETVDRLERGRRRLQQELDD----ATMDLEQQRQLV 1468
Score = 61.6 bits (148), Expect = 2e-09
Identities = 73/357 (20%), Positives = 159/357 (44%), Gaps = 37/357 (10%)
Query: 41 LQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMAL 100
L+++K + Q KE + M+ + +EL E+ + R+ Q++E+++RL L
Sbjct: 1651 LEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGL 1710
Query: 101 SHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADLLGI 160
E +L+EEL S+R+ R +A+Q++D++ +V KA +L
Sbjct: 1711 EAEVLRLQEELAA----SDRA-----------RRQAQQDRDEMADEVANGNLSKAAILEE 1755
Query: 161 VSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSRSAD 220
+L+ +L +E + E ++ + ++ + S T LS RS SA
Sbjct: 1756 KRQLEGRLGQ--------LEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAK 1807
Query: 221 GAKNYFEHEELTVSQLLLCLRE---GNQKVERLEVALKEAKERVSDFEKKTSNRSEI--- 274
A++ + E + +L L E G + ++ +A E+K ++ + + R I
Sbjct: 1808 -AESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSG 1866
Query: 275 ------ETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAELMKK 328
E + + + +E + + + ++E NL+V L ++L+EA + S A+ ++
Sbjct: 1867 KLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRR 1926
Query: 329 RLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQAKTEDEKSK 385
RLQ + + + ++ E+ + + L ++ ++E+ DE+++
Sbjct: 1927 RLQRELEDVTESAESMNREVTTLRNRL-RRGPLTFTTRTVRQVFRLEEGVASDEEAE 1982
Score = 60.5 bits (145), Expect = 4e-09
Identities = 107/473 (22%), Positives = 202/473 (42%), Gaps = 94/473 (19%)
Query: 38 EELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERL 97
E LL ++ H+L+ A ++ QA +L A + ++E E + +
Sbjct: 1539 EALLSSKDDVGKSVHELERACRVAEQAAN----DLRAQVTELEDELTAAEDAKLRLEVTV 1594
Query: 98 MALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADL 157
AL ++E+ L+G+ E E ++ R +AE E+D+ R Q A + L
Sbjct: 1595 QALKTQHER------DLQGRDEAGEERRRQLAKQLR-DAEVERDEERKQRTLAVAARKKL 1647
Query: 158 LGIVSELQLKLNSSG-SSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRS 216
G + EL+ ++ S+G E++ ++R + + +KE+ TRT S
Sbjct: 1648 EGELEELKAQMASAGQGKEEAVKQLR----KMQAQMKELWREVEETRT-----------S 1692
Query: 217 RSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEKKTSNRSEIET 276
R ++N RE ++++ LE + +E E S+R+ +
Sbjct: 1693 REEIFSQN----------------RESEKRLKGLEAEVLRLQE-----ELAASDRARRQA 1731
Query: 277 QTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQA 336
Q ++ DE + EV NL ++ +E ++ +L + E + L+E
Sbjct: 1732 Q------QDRDE------MADEVANGNLSKAAILEEKRQLEGRLGQLE---EELEE---- 1772
Query: 337 LERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQ---AKTEDEKSKL-TVLQMT 392
E+ NS + LN++ +KL LQVES+ +E+ E+ AK E + +L +Q
Sbjct: 1773 -EQSNSEL---LNDRY------RKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQEL 1822
Query: 393 HNKLLQE-------HNNALKTIEELTRKESEKVDRAVLKE-LSEKL-ELAEKALASKQLQ 443
+L +E H + +E + E++++ + LS KL AEK L LQ
Sbjct: 1823 RGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQ 1882
Query: 444 MDEMKQTIAKQEEDLETMTI----LRAQMEVYCSDFHAERAAREKIHEEKEQL 492
++E ++ + + LE + L+ Q+E + +A R ++ E E +
Sbjct: 1883 VEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDV 1935
Score = 58.2 bits (139), Expect = 2e-08
Identities = 118/583 (20%), Positives = 222/583 (38%), Gaps = 52/583 (8%)
Query: 4 QPLSCLTEKEDSPSESTGNGPPHLAHPNLDTFTPEELLQQMKELLTENHQLKEAMKLNNQ 63
Q L + E + + G +A + E L+ EL E + + + Q
Sbjct: 884 QELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQ 943
Query: 64 AMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMAL-----SHENEKLKEELGKL--KG 116
++ EL A +++E + + + K ++ + L + E + K +L K+ +
Sbjct: 944 ELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEA 1003
Query: 117 KSERSSED----PTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSS- 171
K ++ ED +S+L + E + +D+L + AE+ + + +++L+LK ++
Sbjct: 1004 KMKKFEEDLLLLEDQNSKLSK-ERKLLEDRL-AEFSSQAAEEEEKVKSLNKLRLKYEATI 1061
Query: 172 -------GSSEDSFVEIRMAEGEAEGSVKEIKHS--PGPTRTVSTGTALSKYRSRSADGA 222
E E+ + +G E++ R L + + A
Sbjct: 1062 ADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGR-KEEELQAA 1120
Query: 223 KNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEKKTSNRSEIETQTEGST 282
E E +QLL LRE + + L+ + + EK+ + E G
Sbjct: 1121 LARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGEL 1180
Query: 283 EKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNS 342
E D + + S+ E +VT L K L+E T++ EA + + R Q QAL
Sbjct: 1181 EDTLDSTNAQQELRSKREQ---EVTELKKTLEE-ETRIHEAAVQELR-QRHGQALGELAE 1235
Query: 343 AIPSELNEKQELVYTNKKLELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNN 402
+ K T LE +V + +E+ Q ++ + + L++ LQE
Sbjct: 1236 QLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQ----LQEVQG 1291
Query: 403 ALKTIEELTRKESEKVDRA---------VLKELSEKLELAEKALASKQLQMDEMKQTIAK 453
E + +EK+ RA L E K K L+S + Q+ + ++ +
Sbjct: 1292 RAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELL-- 1349
Query: 454 QEEDLETMTI------LRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAVLLKENDAFE 507
QEE + + + A+ E AARE+ E + QL+ + + E
Sbjct: 1350 QEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQE--E 1407
Query: 508 DGGRQSLMEMQSRHGARTSDSDQQAYLVQRGAEDRDWRQQRNI 550
+ G E R AR +++ Q + DR R +R +
Sbjct: 1408 EAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRL 1450
Score = 42.4 bits (98), Expect = 0.001
Identities = 49/227 (21%), Positives = 97/227 (42%), Gaps = 15/227 (6%)
Query: 330 LQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQ---AKTEDEKSKL 386
LQ + Q L++ E EL +LE + + +++ E A+ E+ + +L
Sbjct: 879 LQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRL 938
Query: 387 TVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAV--LKELSEKLELAEKALASKQLQM 444
+ ++ E + EE +R+ + R ++EL LE E A QL+
Sbjct: 939 AARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEK 998
Query: 445 DEMKQTIAKQEEDL-------ETMTILRAQMEVYCSDFHAERAAREKIHEEKEQLALQLA 497
+ + K EEDL ++ R +E ++F ++ A E+ + +L L+
Sbjct: 999 VTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYE 1058
Query: 498 VLLKEND---AFEDGGRQSLMEMQSRHGARTSDSDQQAYLVQRGAED 541
+ + + E+ GRQ L +++ R +S+ +Q Q+ AE+
Sbjct: 1059 ATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEE 1105
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 85.1 bits (209), Expect = 2e-16
Identities = 110/518 (21%), Positives = 226/518 (43%), Gaps = 52/518 (10%)
Query: 39 ELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSA-----WTEKQKEER-------QFF 86
+ L ++ E L + + K A + A++ EL A T +Q+ E+ Q
Sbjct: 1220 QALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQ 1279
Query: 87 EIQSK---------EAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAE 137
E+Q + EA E+L E E + L + + K+ R S++ + E
Sbjct: 1280 EVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQE 1339
Query: 138 QEKDQLRTQVV---RLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKE 194
+++ R ++ R++A +A+ G+ +L+ + + E + E++ A+ + +
Sbjct: 1340 LLQEETRAKLALGSRVRAMEAEAAGLREQLE---EEAAARERAGRELQTAQAQLSEWRRR 1396
Query: 195 IKHSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVAL 254
+ G + G + +R A+ + TV +L R Q+++ + L
Sbjct: 1397 QEEEAG---ALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDL 1453
Query: 255 KEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQ 314
++ ++ VS EKK ++ + + + + +E + E G E EA L +T +E Q
Sbjct: 1454 EQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQ 1513
Query: 315 EAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKM 374
EA +L E + L+ + +AL + ++E + ++ + + ++E++
Sbjct: 1514 EAREEL---ERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELED 1570
Query: 375 EQAKTEDEKSKLTV----LQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKL 430
E ED K +L V L+ H + LQ + A EE R+ ++++ A ++ E+
Sbjct: 1571 ELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAG---EERRRQLAKQLRDAEVERDEERK 1627
Query: 431 ELAEKALASKQLQ--MDEMKQTIAK----QEEDLETMTILRAQMEVYCSDFHAERAAREK 484
+ A K+L+ ++E+K +A +EE ++ + ++AQM+ + R +RE+
Sbjct: 1628 QRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREE 1687
Query: 485 I-----HEEKEQLALQLAVL-LKENDAFEDGGRQSLME 516
I EK L+ VL L+E A D R+ +
Sbjct: 1688 IFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQ 1725
Score = 69.3 bits (168), Expect = 9e-12
Identities = 115/543 (21%), Positives = 208/543 (38%), Gaps = 95/543 (17%)
Query: 38 EELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERL 97
+E L+ + T+ + + + +A++G E+ T Q+E R E + E K+ L
Sbjct: 1141 QEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTL 1200
Query: 98 MALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADL 157
+ +E +EL + G++ + + +R + E+ + L +V L+AE + L
Sbjct: 1201 EEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSL 1260
Query: 158 LGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSR 217
+ EGE E++ L + + R
Sbjct: 1261 ----------------------QTARQEGEQRRRRLELQ--------------LQEVQGR 1284
Query: 218 SADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEKKTSNRSEIETQ 277
+ DG + E E L+ ++E + AL EA+ + K+ S+ E Q
Sbjct: 1285 AGDGERARAEAAEK--------LQRAQAELENVSGALNEAESKTIRLSKELSS---TEAQ 1333
Query: 278 TEGSTEKENDEEKGPETVGSEVEALNLQVTSL--------------FKELQEAHTKLSEA 323
+ E +E + +GS V A+ + L +ELQ A +LSE
Sbjct: 1334 LHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSE- 1392
Query: 324 ELMKKRLQEKCQALE----------RKNSAIPSELNEKQELVYTNKKLELQVESMLSEIK 373
++R +E+ ALE R+ A+ L EK E V ++ +++ L +
Sbjct: 1393 --WRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDAT 1450
Query: 374 MEQAKTEDEKSKLTVLQMTHNKLLQEHNNA-LKTIEELTRKESEKVDRAVL--------- 423
M+ + S L Q ++LL E A L+ +EE R E+E +R
Sbjct: 1451 MDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALE 1510
Query: 424 --KELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLE--------TMTILRAQMEVYCS 473
+E E+LE +AL ++ + K + K +LE LRAQ+
Sbjct: 1511 EEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELED 1570
Query: 474 DFHAERAAREKIHEEKEQLALQLAVLLKEND-AFEDGGRQSLMEMQSRHGARTSDSDQQA 532
+ A A+ ++ + L Q L+ D A E+ RQ +++ R + Q+
Sbjct: 1571 ELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRT 1630
Query: 533 YLV 535
V
Sbjct: 1631 LAV 1633
Score = 65.5 bits (158), Expect = 1e-10
Identities = 116/529 (21%), Positives = 211/529 (39%), Gaps = 81/529 (15%)
Query: 32 LDTFTPEELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEE-------RQ 84
L+ T E +++ +E L + + ++ R E S+ +++E+ R
Sbjct: 988 LEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRL 1047
Query: 85 FFEIQSKEAKERLMALSHENEKLKEELGKLK----GKSERSSEDPTDDSRLP---RAEAE 137
+E + ++RL + EK ++EL KLK G+S E + + RA+
Sbjct: 1048 KYEATIADMEDRL----RKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLG 1103
Query: 138 QEKDQLRTQVVRLQAE---KADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKE 194
+++++L+ + R + E +A LL + E Q L +++ R+A +AE ++
Sbjct: 1104 RKEEELQAALARAEDEGGARAQLLKSLREAQAAL---AEAQEDLESERVARTKAEKQRRD 1160
Query: 195 IKHSPGPTR-----TVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVER 249
+ R T+ + A + RS+ E V++L L E +
Sbjct: 1161 LGEELEALRGELEDTLDSTNAQQELRSK-----------REQEVTELKKTLEE---ETRI 1206
Query: 250 LEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSL 309
E A++E ++R + + + E + +G+ EK AL +V+ L
Sbjct: 1207 HEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTR-------------LALEAEVSEL 1253
Query: 310 FKELQEAHTKLSEAELMKKRLQEKCQALE-RKNSAIPSELNEKQELVYTNKKLELQVESM 368
EL T E E ++RL+ + Q ++ R + ++L +LE V
Sbjct: 1254 RAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELE-NVSGA 1312
Query: 369 LSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTR-KESEKVD-RAVLKEL 426
L+E + + + E S +LLQE A + R E+E R L+E
Sbjct: 1313 LNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEE 1372
Query: 427 SEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERAAREKIH 486
+ E A + L + Q Q+ E ++ +QEE+ + A AR +
Sbjct: 1373 AAARERAGRELQTAQAQLSEWRR---RQEEEAGAL--------------EAGEEARRRAA 1415
Query: 487 EEKEQLALQLAVLLKENDAFEDGGRQSLMEMQSRHGARTSDSDQQAYLV 535
E E L +LA + D E G R+ E+ T D +QQ LV
Sbjct: 1416 REAEALTQRLAEKTETVDRLERGRRRLQQELDD----ATMDLEQQRQLV 1460
Score = 61.6 bits (148), Expect = 2e-09
Identities = 73/357 (20%), Positives = 159/357 (44%), Gaps = 37/357 (10%)
Query: 41 LQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMAL 100
L+++K + Q KE + M+ + +EL E+ + R+ Q++E+++RL L
Sbjct: 1643 LEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGL 1702
Query: 101 SHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADLLGI 160
E +L+EEL S+R+ R +A+Q++D++ +V KA +L
Sbjct: 1703 EAEVLRLQEELAA----SDRA-----------RRQAQQDRDEMADEVANGNLSKAAILEE 1747
Query: 161 VSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSRSAD 220
+L+ +L +E + E ++ + ++ + S T LS RS SA
Sbjct: 1748 KRQLEGRLGQ--------LEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAK 1799
Query: 221 GAKNYFEHEELTVSQLLLCLRE---GNQKVERLEVALKEAKERVSDFEKKTSNRSEI--- 274
A++ + E + +L L E G + ++ +A E+K ++ + + R I
Sbjct: 1800 -AESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSG 1858
Query: 275 ------ETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAELMKK 328
E + + + +E + + + ++E NL+V L ++L+EA + S A+ ++
Sbjct: 1859 KLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRR 1918
Query: 329 RLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQAKTEDEKSK 385
RLQ + + + ++ E+ + + L ++ ++E+ DE+++
Sbjct: 1919 RLQRELEDVTESAESMNREVTTLRNRL-RRGPLTFTTRTVRQVFRLEEGVASDEEAE 1974
Score = 60.5 bits (145), Expect = 4e-09
Identities = 107/473 (22%), Positives = 202/473 (42%), Gaps = 94/473 (19%)
Query: 38 EELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERL 97
E LL ++ H+L+ A ++ QA +L A + ++E E + +
Sbjct: 1531 EALLSSKDDVGKSVHELERACRVAEQAAN----DLRAQVTELEDELTAAEDAKLRLEVTV 1586
Query: 98 MALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADL 157
AL ++E+ L+G+ E E ++ R +AE E+D+ R Q A + L
Sbjct: 1587 QALKTQHER------DLQGRDEAGEERRRQLAKQLR-DAEVERDEERKQRTLAVAARKKL 1639
Query: 158 LGIVSELQLKLNSSG-SSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRS 216
G + EL+ ++ S+G E++ ++R + + +KE+ TRT S
Sbjct: 1640 EGELEELKAQMASAGQGKEEAVKQLR----KMQAQMKELWREVEETRT-----------S 1684
Query: 217 RSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEKKTSNRSEIET 276
R ++N RE ++++ LE + +E E S+R+ +
Sbjct: 1685 REEIFSQN----------------RESEKRLKGLEAEVLRLQE-----ELAASDRARRQA 1723
Query: 277 QTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQA 336
Q ++ DE + EV NL ++ +E ++ +L + E + L+E
Sbjct: 1724 Q------QDRDE------MADEVANGNLSKAAILEEKRQLEGRLGQLE---EELEE---- 1764
Query: 337 LERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQ---AKTEDEKSKL-TVLQMT 392
E+ NS + LN++ +KL LQVES+ +E+ E+ AK E + +L +Q
Sbjct: 1765 -EQSNSEL---LNDRY------RKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQEL 1814
Query: 393 HNKLLQE-------HNNALKTIEELTRKESEKVDRAVLKE-LSEKL-ELAEKALASKQLQ 443
+L +E H + +E + E++++ + LS KL AEK L LQ
Sbjct: 1815 RGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQ 1874
Query: 444 MDEMKQTIAKQEEDLETMTI----LRAQMEVYCSDFHAERAAREKIHEEKEQL 492
++E ++ + + LE + L+ Q+E + +A R ++ E E +
Sbjct: 1875 VEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDV 1927
Score = 58.2 bits (139), Expect = 2e-08
Identities = 118/583 (20%), Positives = 222/583 (38%), Gaps = 52/583 (8%)
Query: 4 QPLSCLTEKEDSPSESTGNGPPHLAHPNLDTFTPEELLQQMKELLTENHQLKEAMKLNNQ 63
Q L + E + + G +A + E L+ EL E + + + Q
Sbjct: 876 QELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQ 935
Query: 64 AMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMAL-----SHENEKLKEELGKL--KG 116
++ EL A +++E + + + K ++ + L + E + K +L K+ +
Sbjct: 936 ELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEA 995
Query: 117 KSERSSED----PTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSS- 171
K ++ ED +S+L + E + +D+L + AE+ + + +++L+LK ++
Sbjct: 996 KMKKFEEDLLLLEDQNSKLSK-ERKLLEDRL-AEFSSQAAEEEEKVKSLNKLRLKYEATI 1053
Query: 172 -------GSSEDSFVEIRMAEGEAEGSVKEIKHS--PGPTRTVSTGTALSKYRSRSADGA 222
E E+ + +G E++ R L + + A
Sbjct: 1054 ADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGR-KEEELQAA 1112
Query: 223 KNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEKKTSNRSEIETQTEGST 282
E E +QLL LRE + + L+ + + EK+ + E G
Sbjct: 1113 LARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGEL 1172
Query: 283 EKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNS 342
E D + + S+ E +VT L K L+E T++ EA + + R Q QAL
Sbjct: 1173 EDTLDSTNAQQELRSKREQ---EVTELKKTLEE-ETRIHEAAVQELR-QRHGQALGELAE 1227
Query: 343 AIPSELNEKQELVYTNKKLELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNN 402
+ K T LE +V + +E+ Q ++ + + L++ LQE
Sbjct: 1228 QLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQ----LQEVQG 1283
Query: 403 ALKTIEELTRKESEKVDRA---------VLKELSEKLELAEKALASKQLQMDEMKQTIAK 453
E + +EK+ RA L E K K L+S + Q+ + ++ +
Sbjct: 1284 RAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELL-- 1341
Query: 454 QEEDLETMTI------LRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAVLLKENDAFE 507
QEE + + + A+ E AARE+ E + QL+ + + E
Sbjct: 1342 QEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQE--E 1399
Query: 508 DGGRQSLMEMQSRHGARTSDSDQQAYLVQRGAEDRDWRQQRNI 550
+ G E R AR +++ Q + DR R +R +
Sbjct: 1400 EAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRL 1442
Score = 42.4 bits (98), Expect = 0.001
Identities = 49/227 (21%), Positives = 97/227 (42%), Gaps = 15/227 (6%)
Query: 330 LQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQ---AKTEDEKSKL 386
LQ + Q L++ E EL +LE + + +++ E A+ E+ + +L
Sbjct: 871 LQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRL 930
Query: 387 TVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAV--LKELSEKLELAEKALASKQLQM 444
+ ++ E + EE +R+ + R ++EL LE E A QL+
Sbjct: 931 AARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEK 990
Query: 445 DEMKQTIAKQEEDL-------ETMTILRAQMEVYCSDFHAERAAREKIHEEKEQLALQLA 497
+ + K EEDL ++ R +E ++F ++ A E+ + +L L+
Sbjct: 991 VTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYE 1050
Query: 498 VLLKEND---AFEDGGRQSLMEMQSRHGARTSDSDQQAYLVQRGAED 541
+ + + E+ GRQ L +++ R +S+ +Q Q+ AE+
Sbjct: 1051 ATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEE 1097
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 85.1 bits (209), Expect = 2e-16
Identities = 110/518 (21%), Positives = 226/518 (43%), Gaps = 52/518 (10%)
Query: 39 ELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSA-----WTEKQKEER-------QFF 86
+ L ++ E L + + K A + A++ EL A T +Q+ E+ Q
Sbjct: 1261 QALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQ 1320
Query: 87 EIQSK---------EAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAE 137
E+Q + EA E+L E E + L + + K+ R S++ + E
Sbjct: 1321 EVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQE 1380
Query: 138 QEKDQLRTQVV---RLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKE 194
+++ R ++ R++A +A+ G+ +L+ + + E + E++ A+ + +
Sbjct: 1381 LLQEETRAKLALGSRVRAMEAEAAGLREQLE---EEAAARERAGRELQTAQAQLSEWRRR 1437
Query: 195 IKHSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVAL 254
+ G + G + +R A+ + TV +L R Q+++ + L
Sbjct: 1438 QEEEAG---ALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDL 1494
Query: 255 KEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQ 314
++ ++ VS EKK ++ + + + + +E + E G E EA L +T +E Q
Sbjct: 1495 EQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQ 1554
Query: 315 EAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKM 374
EA +L E + L+ + +AL + ++E + ++ + + ++E++
Sbjct: 1555 EAREEL---ERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELED 1611
Query: 375 EQAKTEDEKSKLTV----LQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKL 430
E ED K +L V L+ H + LQ + A EE R+ ++++ A ++ E+
Sbjct: 1612 ELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAG---EERRRQLAKQLRDAEVERDEERK 1668
Query: 431 ELAEKALASKQLQ--MDEMKQTIAK----QEEDLETMTILRAQMEVYCSDFHAERAAREK 484
+ A K+L+ ++E+K +A +EE ++ + ++AQM+ + R +RE+
Sbjct: 1669 QRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREE 1728
Query: 485 I-----HEEKEQLALQLAVL-LKENDAFEDGGRQSLME 516
I EK L+ VL L+E A D R+ +
Sbjct: 1729 IFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQ 1766
Score = 69.3 bits (168), Expect = 9e-12
Identities = 115/543 (21%), Positives = 208/543 (38%), Gaps = 95/543 (17%)
Query: 38 EELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERL 97
+E L+ + T+ + + + +A++G E+ T Q+E R E + E K+ L
Sbjct: 1182 QEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTL 1241
Query: 98 MALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADL 157
+ +E +EL + G++ + + +R + E+ + L +V L+AE + L
Sbjct: 1242 EEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSL 1301
Query: 158 LGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSR 217
+ EGE E++ L + + R
Sbjct: 1302 ----------------------QTARQEGEQRRRRLELQ--------------LQEVQGR 1325
Query: 218 SADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEKKTSNRSEIETQ 277
+ DG + E E L+ ++E + AL EA+ + K+ S+ E Q
Sbjct: 1326 AGDGERARAEAAEK--------LQRAQAELENVSGALNEAESKTIRLSKELSS---TEAQ 1374
Query: 278 TEGSTEKENDEEKGPETVGSEVEALNLQVTSL--------------FKELQEAHTKLSEA 323
+ E +E + +GS V A+ + L +ELQ A +LSE
Sbjct: 1375 LHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSE- 1433
Query: 324 ELMKKRLQEKCQALE----------RKNSAIPSELNEKQELVYTNKKLELQVESMLSEIK 373
++R +E+ ALE R+ A+ L EK E V ++ +++ L +
Sbjct: 1434 --WRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDAT 1491
Query: 374 MEQAKTEDEKSKLTVLQMTHNKLLQEHNNA-LKTIEELTRKESEKVDRAVL--------- 423
M+ + S L Q ++LL E A L+ +EE R E+E +R
Sbjct: 1492 MDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALE 1551
Query: 424 --KELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLE--------TMTILRAQMEVYCS 473
+E E+LE +AL ++ + K + K +LE LRAQ+
Sbjct: 1552 EEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELED 1611
Query: 474 DFHAERAAREKIHEEKEQLALQLAVLLKEND-AFEDGGRQSLMEMQSRHGARTSDSDQQA 532
+ A A+ ++ + L Q L+ D A E+ RQ +++ R + Q+
Sbjct: 1612 ELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRT 1671
Query: 533 YLV 535
V
Sbjct: 1672 LAV 1674
Score = 65.5 bits (158), Expect = 1e-10
Identities = 116/529 (21%), Positives = 211/529 (39%), Gaps = 81/529 (15%)
Query: 32 LDTFTPEELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEE-------RQ 84
L+ T E +++ +E L + + ++ R E S+ +++E+ R
Sbjct: 1029 LEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRL 1088
Query: 85 FFEIQSKEAKERLMALSHENEKLKEELGKLK----GKSERSSEDPTDDSRLP---RAEAE 137
+E + ++RL + EK ++EL KLK G+S E + + RA+
Sbjct: 1089 KYEATIADMEDRL----RKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLG 1144
Query: 138 QEKDQLRTQVVRLQAE---KADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKE 194
+++++L+ + R + E +A LL + E Q L +++ R+A +AE ++
Sbjct: 1145 RKEEELQAALARAEDEGGARAQLLKSLREAQAAL---AEAQEDLESERVARTKAEKQRRD 1201
Query: 195 IKHSPGPTR-----TVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVER 249
+ R T+ + A + RS+ E V++L L E +
Sbjct: 1202 LGEELEALRGELEDTLDSTNAQQELRSK-----------REQEVTELKKTLEE---ETRI 1247
Query: 250 LEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSL 309
E A++E ++R + + + E + +G+ EK AL +V+ L
Sbjct: 1248 HEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTR-------------LALEAEVSEL 1294
Query: 310 FKELQEAHTKLSEAELMKKRLQEKCQALE-RKNSAIPSELNEKQELVYTNKKLELQVESM 368
EL T E E ++RL+ + Q ++ R + ++L +LE V
Sbjct: 1295 RAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELE-NVSGA 1353
Query: 369 LSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTR-KESEKVD-RAVLKEL 426
L+E + + + E S +LLQE A + R E+E R L+E
Sbjct: 1354 LNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEE 1413
Query: 427 SEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERAAREKIH 486
+ E A + L + Q Q+ E ++ +QEE+ + A AR +
Sbjct: 1414 AAARERAGRELQTAQAQLSEWRR---RQEEEAGAL--------------EAGEEARRRAA 1456
Query: 487 EEKEQLALQLAVLLKENDAFEDGGRQSLMEMQSRHGARTSDSDQQAYLV 535
E E L +LA + D E G R+ E+ T D +QQ LV
Sbjct: 1457 REAEALTQRLAEKTETVDRLERGRRRLQQELDD----ATMDLEQQRQLV 1501
Score = 61.6 bits (148), Expect = 2e-09
Identities = 73/357 (20%), Positives = 159/357 (44%), Gaps = 37/357 (10%)
Query: 41 LQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMAL 100
L+++K + Q KE + M+ + +EL E+ + R+ Q++E+++RL L
Sbjct: 1684 LEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGL 1743
Query: 101 SHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADLLGI 160
E +L+EEL S+R+ R +A+Q++D++ +V KA +L
Sbjct: 1744 EAEVLRLQEELAA----SDRA-----------RRQAQQDRDEMADEVANGNLSKAAILEE 1788
Query: 161 VSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSRSAD 220
+L+ +L +E + E ++ + ++ + S T LS RS SA
Sbjct: 1789 KRQLEGRLGQ--------LEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAK 1840
Query: 221 GAKNYFEHEELTVSQLLLCLRE---GNQKVERLEVALKEAKERVSDFEKKTSNRSEI--- 274
A++ + E + +L L E G + ++ +A E+K ++ + + R I
Sbjct: 1841 -AESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSG 1899
Query: 275 ------ETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAELMKK 328
E + + + +E + + + ++E NL+V L ++L+EA + S A+ ++
Sbjct: 1900 KLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRR 1959
Query: 329 RLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQAKTEDEKSK 385
RLQ + + + ++ E+ + + L ++ ++E+ DE+++
Sbjct: 1960 RLQRELEDVTESAESMNREVTTLRNRL-RRGPLTFTTRTVRQVFRLEEGVASDEEAE 2015
Score = 60.5 bits (145), Expect = 4e-09
Identities = 107/473 (22%), Positives = 202/473 (42%), Gaps = 94/473 (19%)
Query: 38 EELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERL 97
E LL ++ H+L+ A ++ QA +L A + ++E E + +
Sbjct: 1572 EALLSSKDDVGKSVHELERACRVAEQAAN----DLRAQVTELEDELTAAEDAKLRLEVTV 1627
Query: 98 MALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADL 157
AL ++E+ L+G+ E E ++ R +AE E+D+ R Q A + L
Sbjct: 1628 QALKTQHER------DLQGRDEAGEERRRQLAKQLR-DAEVERDEERKQRTLAVAARKKL 1680
Query: 158 LGIVSELQLKLNSSG-SSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRS 216
G + EL+ ++ S+G E++ ++R + + +KE+ TRT S
Sbjct: 1681 EGELEELKAQMASAGQGKEEAVKQLR----KMQAQMKELWREVEETRT-----------S 1725
Query: 217 RSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEKKTSNRSEIET 276
R ++N RE ++++ LE + +E E S+R+ +
Sbjct: 1726 REEIFSQN----------------RESEKRLKGLEAEVLRLQE-----ELAASDRARRQA 1764
Query: 277 QTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQA 336
Q ++ DE + EV NL ++ +E ++ +L + E + L+E
Sbjct: 1765 Q------QDRDE------MADEVANGNLSKAAILEEKRQLEGRLGQLE---EELEE---- 1805
Query: 337 LERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQ---AKTEDEKSKL-TVLQMT 392
E+ NS + LN++ +KL LQVES+ +E+ E+ AK E + +L +Q
Sbjct: 1806 -EQSNSEL---LNDRY------RKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQEL 1855
Query: 393 HNKLLQE-------HNNALKTIEELTRKESEKVDRAVLKE-LSEKL-ELAEKALASKQLQ 443
+L +E H + +E + E++++ + LS KL AEK L LQ
Sbjct: 1856 RGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQ 1915
Query: 444 MDEMKQTIAKQEEDLETMTI----LRAQMEVYCSDFHAERAAREKIHEEKEQL 492
++E ++ + + LE + L+ Q+E + +A R ++ E E +
Sbjct: 1916 VEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDV 1968
Score = 58.2 bits (139), Expect = 2e-08
Identities = 118/583 (20%), Positives = 222/583 (38%), Gaps = 52/583 (8%)
Query: 4 QPLSCLTEKEDSPSESTGNGPPHLAHPNLDTFTPEELLQQMKELLTENHQLKEAMKLNNQ 63
Q L + E + + G +A + E L+ EL E + + + Q
Sbjct: 917 QELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQ 976
Query: 64 AMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMAL-----SHENEKLKEELGKL--KG 116
++ EL A +++E + + + K ++ + L + E + K +L K+ +
Sbjct: 977 ELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEA 1036
Query: 117 KSERSSED----PTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSS- 171
K ++ ED +S+L + E + +D+L + AE+ + + +++L+LK ++
Sbjct: 1037 KMKKFEEDLLLLEDQNSKLSK-ERKLLEDRL-AEFSSQAAEEEEKVKSLNKLRLKYEATI 1094
Query: 172 -------GSSEDSFVEIRMAEGEAEGSVKEIKHS--PGPTRTVSTGTALSKYRSRSADGA 222
E E+ + +G E++ R L + + A
Sbjct: 1095 ADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGR-KEEELQAA 1153
Query: 223 KNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEKKTSNRSEIETQTEGST 282
E E +QLL LRE + + L+ + + EK+ + E G
Sbjct: 1154 LARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGEL 1213
Query: 283 EKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNS 342
E D + + S+ E +VT L K L+E T++ EA + + R Q QAL
Sbjct: 1214 EDTLDSTNAQQELRSKREQ---EVTELKKTLEE-ETRIHEAAVQELR-QRHGQALGELAE 1268
Query: 343 AIPSELNEKQELVYTNKKLELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNN 402
+ K T LE +V + +E+ Q ++ + + L++ LQE
Sbjct: 1269 QLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQ----LQEVQG 1324
Query: 403 ALKTIEELTRKESEKVDRA---------VLKELSEKLELAEKALASKQLQMDEMKQTIAK 453
E + +EK+ RA L E K K L+S + Q+ + ++ +
Sbjct: 1325 RAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELL-- 1382
Query: 454 QEEDLETMTI------LRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAVLLKENDAFE 507
QEE + + + A+ E AARE+ E + QL+ + + E
Sbjct: 1383 QEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQE--E 1440
Query: 508 DGGRQSLMEMQSRHGARTSDSDQQAYLVQRGAEDRDWRQQRNI 550
+ G E R AR +++ Q + DR R +R +
Sbjct: 1441 EAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRL 1483
Score = 42.4 bits (98), Expect = 0.001
Identities = 49/227 (21%), Positives = 97/227 (42%), Gaps = 15/227 (6%)
Query: 330 LQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQ---AKTEDEKSKL 386
LQ + Q L++ E EL +LE + + +++ E A+ E+ + +L
Sbjct: 912 LQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRL 971
Query: 387 TVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAV--LKELSEKLELAEKALASKQLQM 444
+ ++ E + EE +R+ + R ++EL LE E A QL+
Sbjct: 972 AARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEK 1031
Query: 445 DEMKQTIAKQEEDL-------ETMTILRAQMEVYCSDFHAERAAREKIHEEKEQLALQLA 497
+ + K EEDL ++ R +E ++F ++ A E+ + +L L+
Sbjct: 1032 VTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYE 1091
Query: 498 VLLKEND---AFEDGGRQSLMEMQSRHGARTSDSDQQAYLVQRGAED 541
+ + + E+ GRQ L +++ R +S+ +Q Q+ AE+
Sbjct: 1092 ATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEE 1138
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 84.0 bits (206), Expect = 4e-16
Identities = 112/508 (22%), Positives = 220/508 (43%), Gaps = 49/508 (9%)
Query: 41 LQQMKELLTENHQLKEAMKLNN---QAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERL 97
+ +++E + E Q KE K + Q+++ + EL+ ++ +EE Q + +E K
Sbjct: 1540 ISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQ 1599
Query: 98 MALSHENEKLKEELGKLKGKSERSSE--------DPTDDSRLPRAEAEQEKDQLRTQVVR 149
AL E ++LKE ++ K + S E ++++ E E K+Q TQ +
Sbjct: 1600 EALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLN 1659
Query: 150 LQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHS--PGPTRTVST 207
L+ + + + + L L S ++R E + ++K + TR +
Sbjct: 1660 LENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEK 1719
Query: 208 GTALS------KYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKV--------ERLEVA 253
L K + D + + +S + L N + E L +A
Sbjct: 1720 QEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIA 1779
Query: 254 LKEAKERVSDFEKKTSNRSEIETQTEGSTEK--ENDEEKGPETVGSEVEALNLQVTSLFK 311
KE+ +K SE +T + +K EN K E + E++A Q+ +L K
Sbjct: 1780 HMHLKEQQETIDKLRGIVSE-KTDKLSNMQKDLENSNAKLQEKI-QELKANEHQLITLKK 1837
Query: 312 ELQEAHTKLSEAELMKKRLQEK---CQALERKNSAIPSELNEKQELVYTNKKLELQVESM 368
++ E K+SE E +KK+++++ LE +N + +L+E E + + K + +
Sbjct: 1838 DVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRV 1897
Query: 369 LSEIKME--QAKTEDEKSKLTVLQM-----THNKLLQEHNNALKTIEELTRKESEKVDRA 421
+K+E Q K +++K L++ T L +EH +T+++L K SEK +
Sbjct: 1898 EETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHK---ETVDKLREKISEKTIQI 1954
Query: 422 --VLKELSE-KLELAEK--ALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFH 476
+ K+L + K EL +K L K+LQ+ +K+ + + + M L+ Q E
Sbjct: 1955 SDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQ 2014
Query: 477 AERAAREKIHEEKEQLALQLAVLLKEND 504
+ R ++ ++ + ++ ++ KE D
Sbjct: 2015 SVRMDNFQLTKKLHESLEEIRIVAKERD 2042
Score = 80.5 bits (197), Expect = 4e-15
Identities = 124/561 (22%), Positives = 242/561 (43%), Gaps = 78/561 (13%)
Query: 39 ELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLM 98
EL Q ++ ++ E QLK +K N + EEL ++ K++++ + A ++
Sbjct: 1054 ELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEG 1113
Query: 99 ALSHENEKLKEELGKLKGKSERSSE---------DPTDDSRLPRAEAEQEKDQLRTQVVR 149
LS ++L E KLK KS++ E + + + E E K++L+ + +
Sbjct: 1114 ELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELT 1173
Query: 150 LQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVK-EIKHSPGPTRTVSTG 208
L+ + + L EL KLN + S + R E + S + E H G R +
Sbjct: 1174 LEHMETERL----ELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEAT 1229
Query: 209 TALSKYRSRSADGAKNYFEHEELTVSQLLLCLRE------GNQKVERLEVAL-------- 254
+K + A + EH+E T+ +L + E Q +E+ L
Sbjct: 1230 GLQTKEELKIAH--IHLKEHQE-TIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLH 1286
Query: 255 --KEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKE 312
+E V + + +E+E TE ST K++ T + +E L++ F+E
Sbjct: 1287 EEQELLPNVKEVSETQETMNELELLTEQSTTKDS-------TTLARIEMERLRLNEKFQE 1339
Query: 313 LQEAHTKLSE----AELMKKRLQEKCQALE---RKNSAIPSELNEKQELVYTNKKLELQV 365
QE L++ + +K+ L+ K L+ R+ A E KQE K+ + +
Sbjct: 1340 SQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNET 1399
Query: 366 ESMLSEIKMEQAKTEDEK-SKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDR--AV 422
++SE MEQ K +D ++ + + +K LQE ++ +K++ KE + + R V
Sbjct: 1400 TKIVSE--MEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSV----AKEKDDLQRLQEV 1453
Query: 423 LKELSEKLELAEKALASKQLQMDEMKQT----IAKQEEDLETMTILRAQMEVYCSDFHAE 478
L+ S++L+ K + +K L+ +E + + +QEE + + + ++ E S +
Sbjct: 1454 LQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQ 1513
Query: 479 RAA--------REKIHEEKEQLAL-QLAVL---------LKENDAFEDGGRQSLMEMQSR 520
A ++I+E++EQ + Q++ + KE+ +D QS+
Sbjct: 1514 LEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLE 1573
Query: 521 HGARTSDSDQQAYLVQRGAED 541
R +S ++ ++ + E+
Sbjct: 1574 LTNRLQESQEEIQIMIKEKEE 1594
Score = 65.1 bits (157), Expect = 2e-10
Identities = 112/512 (21%), Positives = 203/512 (39%), Gaps = 71/512 (13%)
Query: 39 ELLQQMKELLTENHQLKEAMK---LNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKE 95
E +++K + E LKE K ++G E+ A + KEE + I KE +E
Sbjct: 1190 ENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQE 1249
Query: 96 RL-----------------MALSHENEKLKEELGKLKGKSE-----RSSEDPTDDSRLPR 133
+ L + KL+EE+ L + E + + +
Sbjct: 1250 TIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELE 1309
Query: 134 AEAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVK 193
EQ + T + R++ E+ L E Q ++ S D+ I+ A
Sbjct: 1310 LLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEA--------L 1361
Query: 194 EIKHSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELT--VSQLLLCLREGNQKVERLE 251
E+KH T + + +S+ + E T VS++ + + + R+E
Sbjct: 1362 EVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQ-FKPKDSALLRIE 1420
Query: 252 VALKEAKERVSDF---------EKKTSNRSEIETQTEGSTEKENDEE---KGPETVGSEV 299
+ + +R+ + EK R + Q+E KEN +E K ET E+
Sbjct: 1421 IEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETE-EEL 1479
Query: 300 EALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNK 359
+ + + + + E LSE E +Q++ +A+ K E+ EK+E N
Sbjct: 1480 KVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQF--NI 1537
Query: 360 KLELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVD 419
K +V+ ++E+K + E K+K + LQ +K+L+ N ++ EE+ EK +
Sbjct: 1538 KQISEVQEKVNELKQFK---EHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEE 1594
Query: 420 RAVLKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLE------TMTILRAQMEVYCS 473
+K + E L++ L + K+ +AK +E E MT + E C
Sbjct: 1595 ---MKRVQEALQIERDQL------KENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCE 1645
Query: 474 DFH-AERAAREKIH-EEKEQLALQLAVLLKEN 503
H E+ +K++ E E ++L +L EN
Sbjct: 1646 IEHLKEQFETQKLNLENIETENIRLTQILHEN 1677
Score = 60.8 bits (146), Expect = 3e-09
Identities = 102/513 (19%), Positives = 208/513 (40%), Gaps = 66/513 (12%)
Query: 39 ELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQF-FEIQSKEAKERL 97
ELL++ ++ + + + ++ KL N M + S KQ ++ F E + +AK
Sbjct: 582 ELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRES 641
Query: 98 MALSHENEKLKEELGKLKGKSERSSED------PTDDSRLPRAEAEQEKDQLRTQVVRLQ 151
L EN +LKE++ +L ++ D + + + + E+E ++ +L
Sbjct: 642 AFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLT 701
Query: 152 AE-----------KADLLGIVSELQLKLNSSGSSEDSF-------VEIRMAEGEAEGSVK 193
+ +L G +++LQ +LN ++ E++ E E K
Sbjct: 702 SLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRK 761
Query: 194 EIKHSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLL---------LCLREGN 244
EI+ +++ D + H+E V LL L + N
Sbjct: 762 EIQDKSEELHIITS----------EKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSN 811
Query: 245 QKVERLEVALKEAKERVSDFEKKTSN-RSEIETQTEGSTEKENDEEKGPETVGSEVEALN 303
K E + K DFE+K E E + + +K ++G+ L+
Sbjct: 812 YKSTDQE--FQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELS 869
Query: 304 LQVTSLFKELQEAHTKLSEAELMKKRLQEK---CQALERKNSAIPSELNEKQELVYTNKK 360
+ L ++ +E +L+E E +K++L+ + Q +ER+ + I +L + E V T +
Sbjct: 870 YKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQ 929
Query: 361 LELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALK----TIEELTRKESE 416
+ ++ + +++E+ + + + + + + L+ +LK TI L K SE
Sbjct: 930 EKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISE 989
Query: 417 KVDRAVLKELSEKLELAEKALASKQLQMDEMKQTIAKQEE----DLETMTILRAQMEVY- 471
+V R + + E + K + +D+ + AK + D++ I+ Q +++
Sbjct: 990 EVSRNL--HMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFS 1047
Query: 472 -CSDFHAERAAREKIHEEKEQLALQLAVLLKEN 503
+ + + E + EKEQL LKEN
Sbjct: 1048 LIQEKNELQQMLESVIAEKEQLKTD----LKEN 1076
Score = 55.8 bits (133), Expect = 1e-07
Identities = 99/484 (20%), Positives = 201/484 (41%), Gaps = 49/484 (10%)
Query: 35 FTPEELLQQMKELLTENHQLK---EAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSK 91
+ P L + + +E + L+ + + L+ + ++ EE+ +++ + +F ++ K
Sbjct: 484 WNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERK 543
Query: 92 EAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQ 151
K++ M L HE LK L +E ++D ++ +++DQ++ +
Sbjct: 544 TKKDQEMQLIHEISNLK----NLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYID 599
Query: 152 AEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSTGTAL 211
++K + +++ L+ S S + +++ +AE + K R S L
Sbjct: 600 SQK------LENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLR--SENLEL 651
Query: 212 SKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEKKTSNR 271
+ A K +L SQL + + L+ A E + S + K
Sbjct: 652 KEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKD 711
Query: 272 SEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAELMKKRLQ 331
+ EG K D +K E EAL +V L E + SE E ++K +Q
Sbjct: 712 LLCNLELEG---KITDLQKELNKEVEENEALREEVIL----LSELKSLPSEVERLRKEIQ 764
Query: 332 EKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQAKTEDEKSKLTVLQM 391
+K + L S EK +L E +V+ +L EI KT+D+ L Q
Sbjct: 765 DKSEELHIITS-------EKDKLFSEVVHKESRVQGLLEEI----GKTKDD---LATTQS 810
Query: 392 THNKLLQEHNNALKTIE-------ELTRKESEKVDRAVLKELSEKLELAEKALASKQLQM 444
+ QE N KT+ ++ +E+E++++ ++ LS++ + + +L + + ++
Sbjct: 811 NYKSTDQEFQN-FKTLHMDFEQKYKMVLEENERMNQEIV-NLSKEAQKFDSSLGALKTEL 868
Query: 445 ----DEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAVLL 500
E+++ + +E L M L+ Q+E S + I E+ +Q ++ L
Sbjct: 869 SYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLT 928
Query: 501 KEND 504
+E D
Sbjct: 929 QEKD 932
Score = 55.5 bits (132), Expect = 1e-07
Identities = 104/528 (19%), Positives = 222/528 (42%), Gaps = 80/528 (15%)
Query: 42 QQMKELLTENHQL-KEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMAL 100
Q+ K +L EN ++ +E + L+ +A K L A + + Q + +++E +ERL
Sbjct: 831 QKYKMVLEENERMNQEIVNLSKEAQKFD-SSLGALKTELSYKTQELQEKTREVQERL--- 886
Query: 101 SHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADLLGI 160
+E E+LKE+L + + T L + +Q ++++T L EK DL +
Sbjct: 887 -NEMEQLKEQLENRDSTLQTVEREKT----LITEKLQQTLEEVKT----LTQEKDDLKQL 937
Query: 161 VSELQLKLNSSGSSEDSFVEIRM-AEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSRSA 219
LQ++ + S V + + + + +++ +K T+ + +S+ SR+
Sbjct: 938 QESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKS--KISEEVSRNL 995
Query: 220 DGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKER---------VSDFEKKTSN 270
+N E ++ +++ ++ + + + + + K+ S ++K
Sbjct: 996 HMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNEL 1055
Query: 271 RSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAELMKKRL 330
+ +E+ + + D ++ E E L L L K+ + + + A + L
Sbjct: 1056 QQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGEL 1115
Query: 331 QEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEI-----KMEQAKTEDEKSK 385
C L + + +L EK + + ++ L V+ +SE+ ++E K E + +
Sbjct: 1116 SRTCDRL----AEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKE 1171
Query: 386 LTVLQMTHNK--LLQEHNNALKTIEELTRKESEKVDRAVLKEL----------------- 426
LT+ M + L Q+ N + ++ +T+ +R VLKEL
Sbjct: 1172 LTLEHMETERLELAQKLNENYEEVKSITK------ERKVLKELQKSFETERDHLRGYIRE 1225
Query: 427 --------SEKLELAEKALASKQLQMDEMKQTIAKQ------EEDLE-TMTILRAQMEVY 471
E+L++A L Q +DE++++++++ +DLE + T L+ ++ V
Sbjct: 1226 IEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPV- 1284
Query: 472 CSDFHAERAAREKIHEEKE-QLALQLAVLLKENDAFEDGGRQSLMEMQ 518
H E+ + E E Q + LL E +D + +EM+
Sbjct: 1285 ---LHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEME 1329
Score = 42.0 bits (97), Expect = 0.002
Identities = 83/453 (18%), Positives = 180/453 (39%), Gaps = 69/453 (15%)
Query: 39 ELLQQMKELLTENHQL---KEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKE 95
E L++++ + E +L KE++K+ E+ A +RQ +++ ++
Sbjct: 2029 ESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIA------RDRQNHQVKPEK--- 2079
Query: 96 RLMA--LSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAE 153
RL++ H E L+E+ ++K +R SE L R + EK+ ++ +
Sbjct: 2080 RLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKE--------IEFQ 2131
Query: 154 KADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSK 213
K + + + L L + E F + E +K++K+ +S T + +
Sbjct: 2132 KELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKY------VLSYVTKIKE 2185
Query: 214 YRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVE-----------------RLEVALKE 256
+ S + + F E +LL+ ++ Q + +E LK+
Sbjct: 2186 EQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKD 2245
Query: 257 AKER-----VSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFK 311
E ++F++ SNR E+ E D EK + E + + QV + F
Sbjct: 2246 FSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRI-CQVNNFF- 2303
Query: 312 ELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSE 371
+ ++ +E+ + ++ L EK E ++ N + +++ L+
Sbjct: 2304 -----NNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQ---TLKTSLAS 2355
Query: 372 IKMEQAKTEDEKS---KLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSE 428
T+D K+ Q+T K+ + N+ + E KES+ + ++ +
Sbjct: 2356 GAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKII------KMQK 2409
Query: 429 KLELAEKALASKQLQMDEMKQTIAKQEEDLETM 461
+LE+ +A Q ++ E + + K +E ++ +
Sbjct: 2410 ELEVTNDIIAKLQAKVHESNKCLEKTKETIQVL 2442
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 83.2 bits (204), Expect = 6e-16
Identities = 121/525 (23%), Positives = 215/525 (40%), Gaps = 68/525 (12%)
Query: 39 ELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTE-----KQKEERQFFEIQSK-- 91
E L+Q K + K+ ++ N + G L + K+K E Q E+QSK
Sbjct: 1210 EQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCS 1269
Query: 92 -------EAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLR 144
E +++ L +E E + L + +GK+ + ++D S QL+
Sbjct: 1270 DGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS-----------SQLQ 1318
Query: 145 TQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRT 204
LQ E L + ++L+ S +D E A+ E + + ++
Sbjct: 1319 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1378
Query: 205 -----VSTGTALSKYRSRSADGAKNY---FEHEELTVSQLLLCLREGNQKVERLEVALKE 256
ST AL + + R +N +E + +L Q+++ L V L
Sbjct: 1379 KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1438
Query: 257 AKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEA 316
++ VS+ EKK ++ + + + K DE E E E L SL + L+EA
Sbjct: 1439 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL---SLARALEEA 1495
Query: 317 HTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESM---LSEIK 373
E E K L+ + + L + ++E ++ + + LE Q+E M L E++
Sbjct: 1496 LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK---SKRALETQMEEMKTQLEELE 1552
Query: 374 MEQAKTEDEKSKLTV------------LQMTHNKLLQEHNNALKTIEEL-TRKESEKVDR 420
E TED K +L V LQ + ++ + + E T E E+ R
Sbjct: 1553 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1612
Query: 421 AVLKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERA 480
A+ +KLE K L +LQ D I +EE ++ + L+AQM+ + + RA
Sbjct: 1613 ALAAAAKKKLEGDLKDL---ELQADS---AIKGREEAIKQLRKLQAQMKDFQRELEDARA 1666
Query: 481 AREKI-----HEEKEQLALQLAVLLKEND--AFEDGGRQSLMEMQ 518
+R++I EK+ +L+ ++ + D A E +Q+ +E +
Sbjct: 1667 SRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKE 1711
Score = 79.0 bits (193), Expect = 1e-14
Identities = 123/601 (20%), Positives = 251/601 (41%), Gaps = 75/601 (12%)
Query: 38 EELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERL 97
E ++ +++ L + + ++ ++ + ++G + + + ++Q + +E L
Sbjct: 1033 ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEEL 1092
Query: 98 MA--------LSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVR 149
A ++ +N LK+ + +L+G ED D R R +AE++K L ++
Sbjct: 1093 QAALARLDDEIAQKNNALKK-IRELEGHISDLQED-LDSERAARNKAEKQKRDLGEELEA 1150
Query: 150 LQAEKADLLGIVS---ELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVS 206
L+ E D L + EL+ K + ++ EA+ KH+ ++
Sbjct: 1151 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA-VEELT 1209
Query: 207 TGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVE----RLEVALKEAKERVS 262
K + D K E E ++ L L + Q+VE +LE ++E + + S
Sbjct: 1210 EQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCS 1269
Query: 263 DFEKKTSNRSE----IETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQE--- 315
D E+ + ++ ++ + E T N+ E + +V +L+ Q+ + LQE
Sbjct: 1270 DGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1329
Query: 316 ----AHTKLSEAELMKKRLQEKC-------QALERKNSAIPSELNEK----QELVYTNKK 360
TKL + E + LQ++ Q LER S + +L++ Q+ T +
Sbjct: 1330 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1389
Query: 361 LELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTR------KE 414
LE + EI+ + E++ + L+ T N+L QE ++ + ++ + K+
Sbjct: 1390 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1449
Query: 415 SEKVDRAVLKELS---------EKLELAEKALASKQLQMDEMKQTIAKQEEDLE-TMTIL 464
K D+ + +E + ++ E + +K L + + + +E+LE T +L
Sbjct: 1450 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1509
Query: 465 RAQMEVYCS-------DFHAERAAREKIHEEKEQLALQLAVLLKENDAFEDGGRQSLMEM 517
+A+ME S + H ++ + + E++ QL L E A ED + + M
Sbjct: 1510 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNM 1569
Query: 518 QSRHG-------ARTSDSDQQAYLVQR-----GAEDRDWRQQRNIPIHSCPKCGEVLPDI 565
Q+ G AR ++++ +QR E D R+QR + + K L D+
Sbjct: 1570 QALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDL 1629
Query: 566 D 566
+
Sbjct: 1630 E 1630
Score = 77.4 bits (189), Expect = 3e-14
Identities = 102/456 (22%), Positives = 189/456 (41%), Gaps = 56/456 (12%)
Query: 78 KQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAE 137
+Q+EE Q E + ++ KER +E ++L+++ +L + E ++ L AEAE
Sbjct: 849 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETEL-YAEAE 907
Query: 138 QEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSG------SSEDSFVEIRMAEGEAEGS 191
+ + VRL A+K +L I+ E++ +L +E + +M + E +
Sbjct: 908 EMR-------VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 960
Query: 192 VKEIKHSPGPTRTVSTGTALSKYRSR--SADGAKNYFEHE----ELTVSQLLLCLREGNQ 245
+E V+ + K D N E E +S L L E +
Sbjct: 961 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1020
Query: 246 KVERLEVALKEAKERVSDFE----KKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEA 301
K + L + + +S+ E K+ +R E+E +D + + +++
Sbjct: 1021 KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1080
Query: 302 LNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKL 361
L +Q+ +ELQ A +L + K +K + LE S + +L+ ++ K
Sbjct: 1081 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA---ARNKA 1137
Query: 362 ELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDR- 420
E Q + E++ + + ED Q K QE K ++E TR +V
Sbjct: 1138 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1197
Query: 421 -----AVLKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDL--ETMTILRAQMEV--- 470
++EL+E+LE ++A A+ +D+ KQT+ K+ DL E + +A+ EV
Sbjct: 1198 RQKHAQAVEELTEQLEQFKRAKAN----LDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1253
Query: 471 -------------YCSDFHAERA-AREKIHEEKEQL 492
CSD RA +K+H+ + ++
Sbjct: 1254 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1289
Score = 75.9 bits (185), Expect = 1e-13
Identities = 110/538 (20%), Positives = 217/538 (40%), Gaps = 55/538 (10%)
Query: 38 EELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERL 97
EE+L +M+ L E + ++ + M + +L E+++ RQ +++ A+ ++
Sbjct: 921 EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKI 980
Query: 98 MALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADL 157
L E + ++ KL K + E+ D AE E++ L +L+ + +
Sbjct: 981 KKLEDEILVMDDQNNKLS-KERKLLEERISDLTTNLAEEEEKAKNL----TKLKNKHESM 1035
Query: 158 LGIVSELQLKLNSSGSSEDSFVEI-RMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRS 216
+SEL+++L S ++ R EG+A ++I + A +
Sbjct: 1036 ---ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK---KE 1089
Query: 217 RSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEKKTSN------ 270
A + E + L +RE + L+ L + + EK+ +
Sbjct: 1090 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE 1149
Query: 271 --RSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEA----- 323
++E+E + + ++ K + V +AL+ + S ++QE K ++A
Sbjct: 1150 ALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT 1209
Query: 324 ------ELMKKRLQEKCQALERKNSAIPSELN----EKQELVYTNKKLELQVESMLSEI- 372
+ K L + Q LE++N+ + EL KQE+ + KKLE QV+ + S+
Sbjct: 1210 EQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCS 1269
Query: 373 --KMEQAKTEDEKSKL-TVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKE---- 425
+ +A+ D+ KL ++ L + A+K +++ S+ D L +
Sbjct: 1270 DGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1329
Query: 426 ----LSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTI----LRAQMEVYCSDFHA 477
+S KL E+ S Q Q+DE + E + T+ I + +++ + S A
Sbjct: 1330 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1389
Query: 478 ERAAREKIHEEKEQLALQLAVLLKENDAFEDGGRQSLMEMQSRHGARTSDSDQQAYLV 535
+++ +E E L Q +E A D ++ +Q D D Q LV
Sbjct: 1390 LEEGKKRFQKEIENLTQQ----YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLV 1443
Score = 74.3 bits (181), Expect = 3e-13
Identities = 120/544 (22%), Positives = 211/544 (38%), Gaps = 93/544 (17%)
Query: 32 LDTFTPEELLQQMKELLT----ENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFE 87
L+ T E ++++++ + +N++L + KL + + L+ EK K +
Sbjct: 971 LEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1030
Query: 88 IQSKEAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQV 147
E + L E EK ++EL KLK K E + D + +A+ + K QL +
Sbjct: 1031 KHESMISELEVRLKKE-EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1089
Query: 148 VRLQAEKA-----------------DLLGIVSELQLKLNSSGSS--------EDSFVEIR 182
LQA A +L G +S+LQ L+S ++ D E+
Sbjct: 1090 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE 1149
Query: 183 MAEGEAEGSV------KEIKHSPGPTRTVSTGTALSKYRSRSA----------------- 219
+ E E ++ +E++ TV + RS A
Sbjct: 1150 ALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT 1209
Query: 220 -------------DGAKNYFEHEELTVSQLLLCLREGNQKVE----RLEVALKEAKERVS 262
D K E E ++ L L + Q+VE +LE ++E + + S
Sbjct: 1210 EQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCS 1269
Query: 263 DFEKKTSNRSE----IETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHT 318
D E+ + ++ ++ + E T N+ E G ++ L V SL +LQ+
Sbjct: 1270 DGERARAELNDKVHKLQNEVESVTGMLNEAE------GKAIK-LAKDVASLSSQLQDTQE 1322
Query: 319 KLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQAK 378
L E K + K + LE + +++ +L+E+ E + LE + ++ +
Sbjct: 1323 LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEME---AKQNLERHISTL-------NIQ 1372
Query: 379 TEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKLELAEKALA 438
D K KL T L + K IE LT++ EK A +L + ++ L
Sbjct: 1373 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA--AAYDKLEKTKNRLQQELD 1430
Query: 439 SKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAV 498
+ +D +Q ++ E+ L A+ + S + ER E EKE AL LA
Sbjct: 1431 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1490
Query: 499 LLKE 502
L+E
Sbjct: 1491 ALEE 1494
Score = 64.7 bits (156), Expect = 2e-10
Identities = 86/447 (19%), Positives = 185/447 (41%), Gaps = 45/447 (10%)
Query: 38 EELLQQMKELLTENHQLKEAMK---LNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAK 94
EE L+ +EL N LK M+ + + EL + + + + Q +E +
Sbjct: 1493 EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1552
Query: 95 ERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRA-------EAEQEKDQLRTQV 147
+ L A +L+ + LKG+ ER + + + R E E E + R Q
Sbjct: 1553 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1612
Query: 148 VRLQAEKADLLGIVSELQLKLNSS-GSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVS 206
A K L G + +L+L+ +S+ E++ ++R + + + +E++ + +
Sbjct: 1613 ALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIF 1672
Query: 207 TGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERL-EVALKEAKERVSDFE 265
++ +++S + L+ L+E ER + A E +E +
Sbjct: 1673 ATAKENEKKAKSLEAD--------------LMQLQEDLAAAERARKQADLEKEELAEELA 1718
Query: 266 KKTSNRSEIETQTE------GSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTK 319
S R+ ++ + E+E +EE+G +EA++ +V ++ ++ +
Sbjct: 1719 SSLSGRNALQDEKRRLEARIAQLEEELEEEQG------NMEAMSDRVRKATQQAEQLSNE 1772
Query: 320 LSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKK-----LELQVESMLSEIKM 374
L+ ++ + Q LER+N + S+L+E + V + K LE ++ + +++
Sbjct: 1773 LATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1832
Query: 375 EQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKLELAE 434
E + + L ++L + + K E+ KE + A +K+L +LE AE
Sbjct: 1833 EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQY--KEQAEKGNARVKQLKRQLEEAE 1890
Query: 435 KALASKQLQMDEMKQTIAKQEEDLETM 461
+ ++++ + + E E M
Sbjct: 1891 EESQRINANRRKLQRELDEATESNEAM 1917
Score = 63.2 bits (152), Expect = 6e-10
Identities = 79/310 (25%), Positives = 149/310 (48%), Gaps = 44/310 (14%)
Query: 271 RSEIETQT-EGSTEKENDEEKGPETVGSEVEALNLQVT---SLFKELQEAHTKL-SEAEL 325
R E E Q E +K + ++ E E+E + Q+T +L +E +A T+L +EAE
Sbjct: 849 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 908
Query: 326 MKKRLQEKCQALERKNSAIPSELNEK----QELVYTNKKLELQVESMLSEIKME------ 375
M+ RL K Q LE + + L E+ Q+L KK+ Q+ + +++ E
Sbjct: 909 MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 968
Query: 376 --------QAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELS 427
+AK + + ++ V+ +NKL +E + I +LT +E+ ++A K L+
Sbjct: 969 LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA--KNLT 1026
Query: 428 EKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERA-AREKIH 486
KL+ +++ S E++ + K+E+ + + L+ ++E SDFH + A + +I
Sbjct: 1027 -KLKNKHESMIS------ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1079
Query: 487 EEKEQLA-----LQLAVL-LKENDAFEDGGRQSLMEMQSRHGARTSDSDQQAYLVQRGAE 540
E K QLA LQ A+ L + A ++ + + E++ D D +R A
Sbjct: 1080 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS-----ERAAR 1134
Query: 541 DRDWRQQRNI 550
++ +Q+R++
Sbjct: 1135 NKAEKQKRDL 1144
Score = 61.2 bits (147), Expect = 2e-09
Identities = 74/307 (24%), Positives = 131/307 (42%), Gaps = 32/307 (10%)
Query: 212 SKYRSRSADGAKNYFE--HEELTVSQLLL---------CLREGNQKVERLEVALKEAKER 260
+K R + A+ E H +LT + LL E + RL +E +E
Sbjct: 864 TKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEI 923
Query: 261 VSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKL 320
+ + E + + Q + +K + E E EA Q L K EA K
Sbjct: 924 LHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR-QKLQLEKVTAEAKIKK 982
Query: 321 SEAELM-----KKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKME 375
E E++ +L ++ + LE + S + + L E++E KL+ + ESM+SE+++
Sbjct: 983 LEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR 1042
Query: 376 QAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKLELAEK 435
K E + +L L+ KL + ++ + I +L +A + EL +L E+
Sbjct: 1043 LKKEEKSRQELEKLK---RKLEGDASDFHEQIADL---------QAQIAELKMQLAKKEE 1090
Query: 436 ALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERAAREKIHEEKEQLALQ 495
L + ++D+ IA++ L+ + L + D +ERAAR K ++K L +
Sbjct: 1091 ELQAALARLDD---EIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEE 1147
Query: 496 LAVLLKE 502
L L E
Sbjct: 1148 LEALKTE 1154
Score = 55.8 bits (133), Expect = 1e-07
Identities = 57/243 (23%), Positives = 112/243 (46%), Gaps = 32/243 (13%)
Query: 304 LQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLEL 363
LQVT +E+Q +L + + +++ + + + LE+K+S + E N QE + +L
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904
Query: 364 QVESM----------LSEIKME-QAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTR 412
+ E M L EI E +A+ E+E+ + LQ K+ Q+ + +EE
Sbjct: 905 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ----MLDLEEQLE 960
Query: 413 KESEKVDRAVLKELSEKLELAEKALASKQLQMDEMKQTIAKQ----EEDLETMTILRAQM 468
+E + L++++ + ++ K L + L MD+ ++K+ EE + +T A+
Sbjct: 961 EEEAARQKLQLEKVTAEAKI--KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1018
Query: 469 EVYCSDFHAERAAREKIHEEKEQLALQLAVLLKENDAFEDGGRQSLMEMQSRHGARTSDS 528
E + K+ + E + +L V LK+ E+ RQ L +++ + SD
Sbjct: 1019 EEKAKNL-------TKLKNKHESMISELEVRLKK----EEKSRQELEKLKRKLEGDASDF 1067
Query: 529 DQQ 531
+Q
Sbjct: 1068 HEQ 1070
Score = 55.5 bits (132), Expect = 1e-07
Identities = 70/324 (21%), Positives = 135/324 (41%), Gaps = 54/324 (16%)
Query: 38 EELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERL 97
EE ++Q+++L Q+K+ + A R +E+ A ++ +++ + E + +E L
Sbjct: 1641 EEAIKQLRKLQA---QMKDFQRELEDARASR-DEIFATAKENEKKAKSLEADLMQLQEDL 1696
Query: 98 MALSH-------ENEKLKEELGK-LKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQV-- 147
A E E+L EEL L G++ E ++R+ + E E E++Q +
Sbjct: 1697 AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1756
Query: 148 --VRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTV 205
VR ++A+ L +EL + +++ +E + ++ E + E++
Sbjct: 1757 DRVRKATQQAEQLS--NELATERSTAQKNESARQQLERQNKELRSKLHEME--------- 1805
Query: 206 STGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFE 265
G SK++S A E ++QL E++E +E + +
Sbjct: 1806 --GAVKSKFKSTIAA--------LEAKIAQL----------EEQVEQEAREKQAATKSLK 1845
Query: 266 KKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAEL 325
+K EI Q E DE K E + E N +V L ++L+EA +
Sbjct: 1846 QKDKKLKEILLQVE-------DERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1898
Query: 326 MKKRLQEKCQALERKNSAIPSELN 349
+++LQ + N A+ E+N
Sbjct: 1899 NRRKLQRELDEATESNEAMGREVN 1922
Score = 36.2 bits (82), Expect = 0.084
Identities = 26/92 (28%), Positives = 44/92 (47%), Gaps = 3/92 (3%)
Query: 42 QQMKELLTE-NHQLKEAMKLNNQAMKG--RFEELSAWTEKQKEERQFFEIQSKEAKERLM 98
+++KE+L + + K A + QA KG R ++L E+ +EE Q ++ + L
Sbjct: 1849 KKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELD 1908
Query: 99 ALSHENEKLKEELGKLKGKSERSSEDPTDDSR 130
+ NE + E+ LK K R +E SR
Sbjct: 1909 EATESNEAMGREVNALKSKLRRGNETSFVPSR 1940
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 83.2 bits (204), Expect = 6e-16
Identities = 121/525 (23%), Positives = 215/525 (40%), Gaps = 68/525 (12%)
Query: 39 ELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTE-----KQKEERQFFEIQSK-- 91
E L+Q K + K+ ++ N + G L + K+K E Q E+QSK
Sbjct: 1217 EQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCS 1276
Query: 92 -------EAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLR 144
E +++ L +E E + L + +GK+ + ++D S QL+
Sbjct: 1277 DGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS-----------SQLQ 1325
Query: 145 TQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRT 204
LQ E L + ++L+ S +D E A+ E + + ++
Sbjct: 1326 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1385
Query: 205 -----VSTGTALSKYRSRSADGAKNY---FEHEELTVSQLLLCLREGNQKVERLEVALKE 256
ST AL + + R +N +E + +L Q+++ L V L
Sbjct: 1386 KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1445
Query: 257 AKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEA 316
++ VS+ EKK ++ + + + K DE E E E L SL + L+EA
Sbjct: 1446 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL---SLARALEEA 1502
Query: 317 HTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESM---LSEIK 373
E E K L+ + + L + ++E ++ + + LE Q+E M L E++
Sbjct: 1503 LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK---SKRALETQMEEMKTQLEELE 1559
Query: 374 MEQAKTEDEKSKLTV------------LQMTHNKLLQEHNNALKTIEEL-TRKESEKVDR 420
E TED K +L V LQ + ++ + + E T E E+ R
Sbjct: 1560 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1619
Query: 421 AVLKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERA 480
A+ +KLE K L +LQ D I +EE ++ + L+AQM+ + + RA
Sbjct: 1620 ALAAAAKKKLEGDLKDL---ELQADS---AIKGREEAIKQLRKLQAQMKDFQRELEDARA 1673
Query: 481 AREKI-----HEEKEQLALQLAVLLKEND--AFEDGGRQSLMEMQ 518
+R++I EK+ +L+ ++ + D A E +Q+ +E +
Sbjct: 1674 SRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKE 1718
Score = 79.0 bits (193), Expect = 1e-14
Identities = 123/601 (20%), Positives = 251/601 (41%), Gaps = 75/601 (12%)
Query: 38 EELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERL 97
E ++ +++ L + + ++ ++ + ++G + + + ++Q + +E L
Sbjct: 1040 ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEEL 1099
Query: 98 MA--------LSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVR 149
A ++ +N LK+ + +L+G ED D R R +AE++K L ++
Sbjct: 1100 QAALARLDDEIAQKNNALKK-IRELEGHISDLQED-LDSERAARNKAEKQKRDLGEELEA 1157
Query: 150 LQAEKADLLGIVS---ELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVS 206
L+ E D L + EL+ K + ++ EA+ KH+ ++
Sbjct: 1158 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA-VEELT 1216
Query: 207 TGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVE----RLEVALKEAKERVS 262
K + D K E E ++ L L + Q+VE +LE ++E + + S
Sbjct: 1217 EQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCS 1276
Query: 263 DFEKKTSNRSE----IETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQE--- 315
D E+ + ++ ++ + E T N+ E + +V +L+ Q+ + LQE
Sbjct: 1277 DGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1336
Query: 316 ----AHTKLSEAELMKKRLQEKC-------QALERKNSAIPSELNEK----QELVYTNKK 360
TKL + E + LQ++ Q LER S + +L++ Q+ T +
Sbjct: 1337 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1396
Query: 361 LELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTR------KE 414
LE + EI+ + E++ + L+ T N+L QE ++ + ++ + K+
Sbjct: 1397 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1456
Query: 415 SEKVDRAVLKELS---------EKLELAEKALASKQLQMDEMKQTIAKQEEDLE-TMTIL 464
K D+ + +E + ++ E + +K L + + + +E+LE T +L
Sbjct: 1457 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1516
Query: 465 RAQMEVYCS-------DFHAERAAREKIHEEKEQLALQLAVLLKENDAFEDGGRQSLMEM 517
+A+ME S + H ++ + + E++ QL L E A ED + + M
Sbjct: 1517 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNM 1576
Query: 518 QSRHG-------ARTSDSDQQAYLVQR-----GAEDRDWRQQRNIPIHSCPKCGEVLPDI 565
Q+ G AR ++++ +QR E D R+QR + + K L D+
Sbjct: 1577 QALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDL 1636
Query: 566 D 566
+
Sbjct: 1637 E 1637
Score = 77.4 bits (189), Expect = 3e-14
Identities = 102/456 (22%), Positives = 189/456 (41%), Gaps = 56/456 (12%)
Query: 78 KQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAE 137
+Q+EE Q E + ++ KER +E ++L+++ +L + E ++ L AEAE
Sbjct: 856 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETEL-YAEAE 914
Query: 138 QEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSG------SSEDSFVEIRMAEGEAEGS 191
+ + VRL A+K +L I+ E++ +L +E + +M + E +
Sbjct: 915 EMR-------VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 967
Query: 192 VKEIKHSPGPTRTVSTGTALSKYRSR--SADGAKNYFEHE----ELTVSQLLLCLREGNQ 245
+E V+ + K D N E E +S L L E +
Sbjct: 968 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1027
Query: 246 KVERLEVALKEAKERVSDFE----KKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEA 301
K + L + + +S+ E K+ +R E+E +D + + +++
Sbjct: 1028 KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1087
Query: 302 LNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKL 361
L +Q+ +ELQ A +L + K +K + LE S + +L+ ++ K
Sbjct: 1088 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA---ARNKA 1144
Query: 362 ELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDR- 420
E Q + E++ + + ED Q K QE K ++E TR +V
Sbjct: 1145 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1204
Query: 421 -----AVLKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDL--ETMTILRAQMEV--- 470
++EL+E+LE ++A A+ +D+ KQT+ K+ DL E + +A+ EV
Sbjct: 1205 RQKHAQAVEELTEQLEQFKRAKAN----LDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1260
Query: 471 -------------YCSDFHAERA-AREKIHEEKEQL 492
CSD RA +K+H+ + ++
Sbjct: 1261 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1296
Score = 75.9 bits (185), Expect = 1e-13
Identities = 110/538 (20%), Positives = 217/538 (40%), Gaps = 55/538 (10%)
Query: 38 EELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERL 97
EE+L +M+ L E + ++ + M + +L E+++ RQ +++ A+ ++
Sbjct: 928 EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKI 987
Query: 98 MALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADL 157
L E + ++ KL K + E+ D AE E++ L +L+ + +
Sbjct: 988 KKLEDEILVMDDQNNKLS-KERKLLEERISDLTTNLAEEEEKAKNL----TKLKNKHESM 1042
Query: 158 LGIVSELQLKLNSSGSSEDSFVEI-RMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRS 216
+SEL+++L S ++ R EG+A ++I + A +
Sbjct: 1043 ---ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK---KE 1096
Query: 217 RSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEKKTSN------ 270
A + E + L +RE + L+ L + + EK+ +
Sbjct: 1097 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE 1156
Query: 271 --RSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEA----- 323
++E+E + + ++ K + V +AL+ + S ++QE K ++A
Sbjct: 1157 ALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT 1216
Query: 324 ------ELMKKRLQEKCQALERKNSAIPSELN----EKQELVYTNKKLELQVESMLSEI- 372
+ K L + Q LE++N+ + EL KQE+ + KKLE QV+ + S+
Sbjct: 1217 EQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCS 1276
Query: 373 --KMEQAKTEDEKSKL-TVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKE---- 425
+ +A+ D+ KL ++ L + A+K +++ S+ D L +
Sbjct: 1277 DGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1336
Query: 426 ----LSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTI----LRAQMEVYCSDFHA 477
+S KL E+ S Q Q+DE + E + T+ I + +++ + S A
Sbjct: 1337 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1396
Query: 478 ERAAREKIHEEKEQLALQLAVLLKENDAFEDGGRQSLMEMQSRHGARTSDSDQQAYLV 535
+++ +E E L Q +E A D ++ +Q D D Q LV
Sbjct: 1397 LEEGKKRFQKEIENLTQQ----YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLV 1450
Score = 74.3 bits (181), Expect = 3e-13
Identities = 120/544 (22%), Positives = 211/544 (38%), Gaps = 93/544 (17%)
Query: 32 LDTFTPEELLQQMKELLT----ENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFE 87
L+ T E ++++++ + +N++L + KL + + L+ EK K +
Sbjct: 978 LEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1037
Query: 88 IQSKEAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQV 147
E + L E EK ++EL KLK K E + D + +A+ + K QL +
Sbjct: 1038 KHESMISELEVRLKKE-EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1096
Query: 148 VRLQAEKA-----------------DLLGIVSELQLKLNSSGSS--------EDSFVEIR 182
LQA A +L G +S+LQ L+S ++ D E+
Sbjct: 1097 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE 1156
Query: 183 MAEGEAEGSV------KEIKHSPGPTRTVSTGTALSKYRSRSA----------------- 219
+ E E ++ +E++ TV + RS A
Sbjct: 1157 ALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT 1216
Query: 220 -------------DGAKNYFEHEELTVSQLLLCLREGNQKVE----RLEVALKEAKERVS 262
D K E E ++ L L + Q+VE +LE ++E + + S
Sbjct: 1217 EQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCS 1276
Query: 263 DFEKKTSNRSE----IETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHT 318
D E+ + ++ ++ + E T N+ E G ++ L V SL +LQ+
Sbjct: 1277 DGERARAELNDKVHKLQNEVESVTGMLNEAE------GKAIK-LAKDVASLSSQLQDTQE 1329
Query: 319 KLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQAK 378
L E K + K + LE + +++ +L+E+ E + LE + ++ +
Sbjct: 1330 LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEME---AKQNLERHISTL-------NIQ 1379
Query: 379 TEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKLELAEKALA 438
D K KL T L + K IE LT++ EK A +L + ++ L
Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA--AAYDKLEKTKNRLQQELD 1437
Query: 439 SKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAV 498
+ +D +Q ++ E+ L A+ + S + ER E EKE AL LA
Sbjct: 1438 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1497
Query: 499 LLKE 502
L+E
Sbjct: 1498 ALEE 1501
Score = 64.7 bits (156), Expect = 2e-10
Identities = 86/447 (19%), Positives = 185/447 (41%), Gaps = 45/447 (10%)
Query: 38 EELLQQMKELLTENHQLKEAMK---LNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAK 94
EE L+ +EL N LK M+ + + EL + + + + Q +E +
Sbjct: 1500 EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1559
Query: 95 ERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRA-------EAEQEKDQLRTQV 147
+ L A +L+ + LKG+ ER + + + R E E E + R Q
Sbjct: 1560 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1619
Query: 148 VRLQAEKADLLGIVSELQLKLNSS-GSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVS 206
A K L G + +L+L+ +S+ E++ ++R + + + +E++ + +
Sbjct: 1620 ALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIF 1679
Query: 207 TGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERL-EVALKEAKERVSDFE 265
++ +++S + L+ L+E ER + A E +E +
Sbjct: 1680 ATAKENEKKAKSLEAD--------------LMQLQEDLAAAERARKQADLEKEELAEELA 1725
Query: 266 KKTSNRSEIETQTE------GSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTK 319
S R+ ++ + E+E +EE+G +EA++ +V ++ ++ +
Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQG------NMEAMSDRVRKATQQAEQLSNE 1779
Query: 320 LSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKK-----LELQVESMLSEIKM 374
L+ ++ + Q LER+N + S+L+E + V + K LE ++ + +++
Sbjct: 1780 LATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1839
Query: 375 EQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKLELAE 434
E + + L ++L + + K E+ KE + A +K+L +LE AE
Sbjct: 1840 EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQY--KEQAEKGNARVKQLKRQLEEAE 1897
Query: 435 KALASKQLQMDEMKQTIAKQEEDLETM 461
+ ++++ + + E E M
Sbjct: 1898 EESQRINANRRKLQRELDEATESNEAM 1924
Score = 63.2 bits (152), Expect = 6e-10
Identities = 79/310 (25%), Positives = 149/310 (48%), Gaps = 44/310 (14%)
Query: 271 RSEIETQT-EGSTEKENDEEKGPETVGSEVEALNLQVT---SLFKELQEAHTKL-SEAEL 325
R E E Q E +K + ++ E E+E + Q+T +L +E +A T+L +EAE
Sbjct: 856 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 915
Query: 326 MKKRLQEKCQALERKNSAIPSELNEK----QELVYTNKKLELQVESMLSEIKME------ 375
M+ RL K Q LE + + L E+ Q+L KK+ Q+ + +++ E
Sbjct: 916 MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 975
Query: 376 --------QAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELS 427
+AK + + ++ V+ +NKL +E + I +LT +E+ ++A K L+
Sbjct: 976 LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA--KNLT 1033
Query: 428 EKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERA-AREKIH 486
KL+ +++ S E++ + K+E+ + + L+ ++E SDFH + A + +I
Sbjct: 1034 -KLKNKHESMIS------ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1086
Query: 487 EEKEQLA-----LQLAVL-LKENDAFEDGGRQSLMEMQSRHGARTSDSDQQAYLVQRGAE 540
E K QLA LQ A+ L + A ++ + + E++ D D +R A
Sbjct: 1087 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS-----ERAAR 1141
Query: 541 DRDWRQQRNI 550
++ +Q+R++
Sbjct: 1142 NKAEKQKRDL 1151
Score = 61.2 bits (147), Expect = 2e-09
Identities = 74/307 (24%), Positives = 131/307 (42%), Gaps = 32/307 (10%)
Query: 212 SKYRSRSADGAKNYFE--HEELTVSQLLL---------CLREGNQKVERLEVALKEAKER 260
+K R + A+ E H +LT + LL E + RL +E +E
Sbjct: 871 TKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEI 930
Query: 261 VSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKL 320
+ + E + + Q + +K + E E EA Q L K EA K
Sbjct: 931 LHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR-QKLQLEKVTAEAKIKK 989
Query: 321 SEAELM-----KKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKME 375
E E++ +L ++ + LE + S + + L E++E KL+ + ESM+SE+++
Sbjct: 990 LEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR 1049
Query: 376 QAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKLELAEK 435
K E + +L L+ KL + ++ + I +L +A + EL +L E+
Sbjct: 1050 LKKEEKSRQELEKLK---RKLEGDASDFHEQIADL---------QAQIAELKMQLAKKEE 1097
Query: 436 ALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERAAREKIHEEKEQLALQ 495
L + ++D+ IA++ L+ + L + D +ERAAR K ++K L +
Sbjct: 1098 ELQAALARLDD---EIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEE 1154
Query: 496 LAVLLKE 502
L L E
Sbjct: 1155 LEALKTE 1161
Score = 55.8 bits (133), Expect = 1e-07
Identities = 57/243 (23%), Positives = 112/243 (46%), Gaps = 32/243 (13%)
Query: 304 LQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLEL 363
LQVT +E+Q +L + + +++ + + + LE+K+S + E N QE + +L
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911
Query: 364 QVESM----------LSEIKME-QAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTR 412
+ E M L EI E +A+ E+E+ + LQ K+ Q+ + +EE
Sbjct: 912 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ----MLDLEEQLE 967
Query: 413 KESEKVDRAVLKELSEKLELAEKALASKQLQMDEMKQTIAKQ----EEDLETMTILRAQM 468
+E + L++++ + ++ K L + L MD+ ++K+ EE + +T A+
Sbjct: 968 EEEAARQKLQLEKVTAEAKI--KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1025
Query: 469 EVYCSDFHAERAAREKIHEEKEQLALQLAVLLKENDAFEDGGRQSLMEMQSRHGARTSDS 528
E + K+ + E + +L V LK+ E+ RQ L +++ + SD
Sbjct: 1026 EEKAKNL-------TKLKNKHESMISELEVRLKK----EEKSRQELEKLKRKLEGDASDF 1074
Query: 529 DQQ 531
+Q
Sbjct: 1075 HEQ 1077
Score = 55.5 bits (132), Expect = 1e-07
Identities = 70/324 (21%), Positives = 135/324 (41%), Gaps = 54/324 (16%)
Query: 38 EELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERL 97
EE ++Q+++L Q+K+ + A R +E+ A ++ +++ + E + +E L
Sbjct: 1648 EEAIKQLRKLQA---QMKDFQRELEDARASR-DEIFATAKENEKKAKSLEADLMQLQEDL 1703
Query: 98 MALSH-------ENEKLKEELGK-LKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQV-- 147
A E E+L EEL L G++ E ++R+ + E E E++Q +
Sbjct: 1704 AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1763
Query: 148 --VRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTV 205
VR ++A+ L +EL + +++ +E + ++ E + E++
Sbjct: 1764 DRVRKATQQAEQLS--NELATERSTAQKNESARQQLERQNKELRSKLHEME--------- 1812
Query: 206 STGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFE 265
G SK++S A E ++QL E++E +E + +
Sbjct: 1813 --GAVKSKFKSTIAA--------LEAKIAQL----------EEQVEQEAREKQAATKSLK 1852
Query: 266 KKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAEL 325
+K EI Q E DE K E + E N +V L ++L+EA +
Sbjct: 1853 QKDKKLKEILLQVE-------DERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1905
Query: 326 MKKRLQEKCQALERKNSAIPSELN 349
+++LQ + N A+ E+N
Sbjct: 1906 NRRKLQRELDEATESNEAMGREVN 1929
Score = 36.2 bits (82), Expect = 0.084
Identities = 26/92 (28%), Positives = 44/92 (47%), Gaps = 3/92 (3%)
Query: 42 QQMKELLTE-NHQLKEAMKLNNQAMKG--RFEELSAWTEKQKEERQFFEIQSKEAKERLM 98
+++KE+L + + K A + QA KG R ++L E+ +EE Q ++ + L
Sbjct: 1856 KKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELD 1915
Query: 99 ALSHENEKLKEELGKLKGKSERSSEDPTDDSR 130
+ NE + E+ LK K R +E SR
Sbjct: 1916 EATESNEAMGREVNALKSKLRRGNETSFVPSR 1947
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 83.2 bits (204), Expect = 6e-16
Identities = 121/525 (23%), Positives = 215/525 (40%), Gaps = 68/525 (12%)
Query: 39 ELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTE-----KQKEERQFFEIQSK-- 91
E L+Q K + K+ ++ N + G L + K+K E Q E+QSK
Sbjct: 1217 EQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCS 1276
Query: 92 -------EAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLR 144
E +++ L +E E + L + +GK+ + ++D S QL+
Sbjct: 1277 DGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS-----------SQLQ 1325
Query: 145 TQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRT 204
LQ E L + ++L+ S +D E A+ E + + ++
Sbjct: 1326 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1385
Query: 205 -----VSTGTALSKYRSRSADGAKNY---FEHEELTVSQLLLCLREGNQKVERLEVALKE 256
ST AL + + R +N +E + +L Q+++ L V L
Sbjct: 1386 KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1445
Query: 257 AKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEA 316
++ VS+ EKK ++ + + + K DE E E E L SL + L+EA
Sbjct: 1446 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL---SLARALEEA 1502
Query: 317 HTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESM---LSEIK 373
E E K L+ + + L + ++E ++ + + LE Q+E M L E++
Sbjct: 1503 LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK---SKRALETQMEEMKTQLEELE 1559
Query: 374 MEQAKTEDEKSKLTV------------LQMTHNKLLQEHNNALKTIEEL-TRKESEKVDR 420
E TED K +L V LQ + ++ + + E T E E+ R
Sbjct: 1560 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1619
Query: 421 AVLKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERA 480
A+ +KLE K L +LQ D I +EE ++ + L+AQM+ + + RA
Sbjct: 1620 ALAAAAKKKLEGDLKDL---ELQADS---AIKGREEAIKQLRKLQAQMKDFQRELEDARA 1673
Query: 481 AREKI-----HEEKEQLALQLAVLLKEND--AFEDGGRQSLMEMQ 518
+R++I EK+ +L+ ++ + D A E +Q+ +E +
Sbjct: 1674 SRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKE 1718
Score = 79.0 bits (193), Expect = 1e-14
Identities = 123/601 (20%), Positives = 251/601 (41%), Gaps = 75/601 (12%)
Query: 38 EELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERL 97
E ++ +++ L + + ++ ++ + ++G + + + ++Q + +E L
Sbjct: 1040 ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEEL 1099
Query: 98 MA--------LSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVR 149
A ++ +N LK+ + +L+G ED D R R +AE++K L ++
Sbjct: 1100 QAALARLDDEIAQKNNALKK-IRELEGHISDLQED-LDSERAARNKAEKQKRDLGEELEA 1157
Query: 150 LQAEKADLLGIVS---ELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVS 206
L+ E D L + EL+ K + ++ EA+ KH+ ++
Sbjct: 1158 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA-VEELT 1216
Query: 207 TGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVE----RLEVALKEAKERVS 262
K + D K E E ++ L L + Q+VE +LE ++E + + S
Sbjct: 1217 EQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCS 1276
Query: 263 DFEKKTSNRSE----IETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQE--- 315
D E+ + ++ ++ + E T N+ E + +V +L+ Q+ + LQE
Sbjct: 1277 DGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1336
Query: 316 ----AHTKLSEAELMKKRLQEKC-------QALERKNSAIPSELNEK----QELVYTNKK 360
TKL + E + LQ++ Q LER S + +L++ Q+ T +
Sbjct: 1337 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1396
Query: 361 LELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTR------KE 414
LE + EI+ + E++ + L+ T N+L QE ++ + ++ + K+
Sbjct: 1397 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1456
Query: 415 SEKVDRAVLKELS---------EKLELAEKALASKQLQMDEMKQTIAKQEEDLE-TMTIL 464
K D+ + +E + ++ E + +K L + + + +E+LE T +L
Sbjct: 1457 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1516
Query: 465 RAQMEVYCS-------DFHAERAAREKIHEEKEQLALQLAVLLKENDAFEDGGRQSLMEM 517
+A+ME S + H ++ + + E++ QL L E A ED + + M
Sbjct: 1517 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNM 1576
Query: 518 QSRHG-------ARTSDSDQQAYLVQR-----GAEDRDWRQQRNIPIHSCPKCGEVLPDI 565
Q+ G AR ++++ +QR E D R+QR + + K L D+
Sbjct: 1577 QALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDL 1636
Query: 566 D 566
+
Sbjct: 1637 E 1637
Score = 77.4 bits (189), Expect = 3e-14
Identities = 102/456 (22%), Positives = 189/456 (41%), Gaps = 56/456 (12%)
Query: 78 KQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAE 137
+Q+EE Q E + ++ KER +E ++L+++ +L + E ++ L AEAE
Sbjct: 856 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETEL-YAEAE 914
Query: 138 QEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSG------SSEDSFVEIRMAEGEAEGS 191
+ + VRL A+K +L I+ E++ +L +E + +M + E +
Sbjct: 915 EMR-------VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 967
Query: 192 VKEIKHSPGPTRTVSTGTALSKYRSR--SADGAKNYFEHE----ELTVSQLLLCLREGNQ 245
+E V+ + K D N E E +S L L E +
Sbjct: 968 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1027
Query: 246 KVERLEVALKEAKERVSDFE----KKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEA 301
K + L + + +S+ E K+ +R E+E +D + + +++
Sbjct: 1028 KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1087
Query: 302 LNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKL 361
L +Q+ +ELQ A +L + K +K + LE S + +L+ ++ K
Sbjct: 1088 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA---ARNKA 1144
Query: 362 ELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDR- 420
E Q + E++ + + ED Q K QE K ++E TR +V
Sbjct: 1145 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1204
Query: 421 -----AVLKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDL--ETMTILRAQMEV--- 470
++EL+E+LE ++A A+ +D+ KQT+ K+ DL E + +A+ EV
Sbjct: 1205 RQKHAQAVEELTEQLEQFKRAKAN----LDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1260
Query: 471 -------------YCSDFHAERA-AREKIHEEKEQL 492
CSD RA +K+H+ + ++
Sbjct: 1261 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1296
Score = 75.9 bits (185), Expect = 1e-13
Identities = 110/538 (20%), Positives = 217/538 (40%), Gaps = 55/538 (10%)
Query: 38 EELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERL 97
EE+L +M+ L E + ++ + M + +L E+++ RQ +++ A+ ++
Sbjct: 928 EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKI 987
Query: 98 MALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADL 157
L E + ++ KL K + E+ D AE E++ L +L+ + +
Sbjct: 988 KKLEDEILVMDDQNNKLS-KERKLLEERISDLTTNLAEEEEKAKNL----TKLKNKHESM 1042
Query: 158 LGIVSELQLKLNSSGSSEDSFVEI-RMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRS 216
+SEL+++L S ++ R EG+A ++I + A +
Sbjct: 1043 ---ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK---KE 1096
Query: 217 RSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEKKTSN------ 270
A + E + L +RE + L+ L + + EK+ +
Sbjct: 1097 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE 1156
Query: 271 --RSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEA----- 323
++E+E + + ++ K + V +AL+ + S ++QE K ++A
Sbjct: 1157 ALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT 1216
Query: 324 ------ELMKKRLQEKCQALERKNSAIPSELN----EKQELVYTNKKLELQVESMLSEI- 372
+ K L + Q LE++N+ + EL KQE+ + KKLE QV+ + S+
Sbjct: 1217 EQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCS 1276
Query: 373 --KMEQAKTEDEKSKL-TVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKE---- 425
+ +A+ D+ KL ++ L + A+K +++ S+ D L +
Sbjct: 1277 DGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1336
Query: 426 ----LSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTI----LRAQMEVYCSDFHA 477
+S KL E+ S Q Q+DE + E + T+ I + +++ + S A
Sbjct: 1337 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1396
Query: 478 ERAAREKIHEEKEQLALQLAVLLKENDAFEDGGRQSLMEMQSRHGARTSDSDQQAYLV 535
+++ +E E L Q +E A D ++ +Q D D Q LV
Sbjct: 1397 LEEGKKRFQKEIENLTQQ----YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLV 1450
Score = 74.3 bits (181), Expect = 3e-13
Identities = 120/544 (22%), Positives = 211/544 (38%), Gaps = 93/544 (17%)
Query: 32 LDTFTPEELLQQMKELLT----ENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFE 87
L+ T E ++++++ + +N++L + KL + + L+ EK K +
Sbjct: 978 LEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1037
Query: 88 IQSKEAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQV 147
E + L E EK ++EL KLK K E + D + +A+ + K QL +
Sbjct: 1038 KHESMISELEVRLKKE-EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1096
Query: 148 VRLQAEKA-----------------DLLGIVSELQLKLNSSGSS--------EDSFVEIR 182
LQA A +L G +S+LQ L+S ++ D E+
Sbjct: 1097 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE 1156
Query: 183 MAEGEAEGSV------KEIKHSPGPTRTVSTGTALSKYRSRSA----------------- 219
+ E E ++ +E++ TV + RS A
Sbjct: 1157 ALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT 1216
Query: 220 -------------DGAKNYFEHEELTVSQLLLCLREGNQKVE----RLEVALKEAKERVS 262
D K E E ++ L L + Q+VE +LE ++E + + S
Sbjct: 1217 EQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCS 1276
Query: 263 DFEKKTSNRSE----IETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHT 318
D E+ + ++ ++ + E T N+ E G ++ L V SL +LQ+
Sbjct: 1277 DGERARAELNDKVHKLQNEVESVTGMLNEAE------GKAIK-LAKDVASLSSQLQDTQE 1329
Query: 319 KLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQAK 378
L E K + K + LE + +++ +L+E+ E + LE + ++ +
Sbjct: 1330 LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEME---AKQNLERHISTL-------NIQ 1379
Query: 379 TEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKLELAEKALA 438
D K KL T L + K IE LT++ EK A +L + ++ L
Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA--AAYDKLEKTKNRLQQELD 1437
Query: 439 SKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAV 498
+ +D +Q ++ E+ L A+ + S + ER E EKE AL LA
Sbjct: 1438 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1497
Query: 499 LLKE 502
L+E
Sbjct: 1498 ALEE 1501
Score = 64.7 bits (156), Expect = 2e-10
Identities = 86/447 (19%), Positives = 185/447 (41%), Gaps = 45/447 (10%)
Query: 38 EELLQQMKELLTENHQLKEAMK---LNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAK 94
EE L+ +EL N LK M+ + + EL + + + + Q +E +
Sbjct: 1500 EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1559
Query: 95 ERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRA-------EAEQEKDQLRTQV 147
+ L A +L+ + LKG+ ER + + + R E E E + R Q
Sbjct: 1560 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1619
Query: 148 VRLQAEKADLLGIVSELQLKLNSS-GSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVS 206
A K L G + +L+L+ +S+ E++ ++R + + + +E++ + +
Sbjct: 1620 ALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIF 1679
Query: 207 TGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERL-EVALKEAKERVSDFE 265
++ +++S + L+ L+E ER + A E +E +
Sbjct: 1680 ATAKENEKKAKSLEAD--------------LMQLQEDLAAAERARKQADLEKEELAEELA 1725
Query: 266 KKTSNRSEIETQTE------GSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTK 319
S R+ ++ + E+E +EE+G +EA++ +V ++ ++ +
Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQG------NMEAMSDRVRKATQQAEQLSNE 1779
Query: 320 LSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKK-----LELQVESMLSEIKM 374
L+ ++ + Q LER+N + S+L+E + V + K LE ++ + +++
Sbjct: 1780 LATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1839
Query: 375 EQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKLELAE 434
E + + L ++L + + K E+ KE + A +K+L +LE AE
Sbjct: 1840 EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQY--KEQAEKGNARVKQLKRQLEEAE 1897
Query: 435 KALASKQLQMDEMKQTIAKQEEDLETM 461
+ ++++ + + E E M
Sbjct: 1898 EESQRINANRRKLQRELDEATESNEAM 1924
Score = 63.2 bits (152), Expect = 6e-10
Identities = 79/310 (25%), Positives = 149/310 (48%), Gaps = 44/310 (14%)
Query: 271 RSEIETQT-EGSTEKENDEEKGPETVGSEVEALNLQVT---SLFKELQEAHTKL-SEAEL 325
R E E Q E +K + ++ E E+E + Q+T +L +E +A T+L +EAE
Sbjct: 856 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 915
Query: 326 MKKRLQEKCQALERKNSAIPSELNEK----QELVYTNKKLELQVESMLSEIKME------ 375
M+ RL K Q LE + + L E+ Q+L KK+ Q+ + +++ E
Sbjct: 916 MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 975
Query: 376 --------QAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELS 427
+AK + + ++ V+ +NKL +E + I +LT +E+ ++A K L+
Sbjct: 976 LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA--KNLT 1033
Query: 428 EKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERA-AREKIH 486
KL+ +++ S E++ + K+E+ + + L+ ++E SDFH + A + +I
Sbjct: 1034 -KLKNKHESMIS------ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1086
Query: 487 EEKEQLA-----LQLAVL-LKENDAFEDGGRQSLMEMQSRHGARTSDSDQQAYLVQRGAE 540
E K QLA LQ A+ L + A ++ + + E++ D D +R A
Sbjct: 1087 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS-----ERAAR 1141
Query: 541 DRDWRQQRNI 550
++ +Q+R++
Sbjct: 1142 NKAEKQKRDL 1151
Score = 61.2 bits (147), Expect = 2e-09
Identities = 74/307 (24%), Positives = 131/307 (42%), Gaps = 32/307 (10%)
Query: 212 SKYRSRSADGAKNYFE--HEELTVSQLLL---------CLREGNQKVERLEVALKEAKER 260
+K R + A+ E H +LT + LL E + RL +E +E
Sbjct: 871 TKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEI 930
Query: 261 VSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKL 320
+ + E + + Q + +K + E E EA Q L K EA K
Sbjct: 931 LHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR-QKLQLEKVTAEAKIKK 989
Query: 321 SEAELM-----KKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKME 375
E E++ +L ++ + LE + S + + L E++E KL+ + ESM+SE+++
Sbjct: 990 LEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR 1049
Query: 376 QAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKLELAEK 435
K E + +L L+ KL + ++ + I +L +A + EL +L E+
Sbjct: 1050 LKKEEKSRQELEKLK---RKLEGDASDFHEQIADL---------QAQIAELKMQLAKKEE 1097
Query: 436 ALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERAAREKIHEEKEQLALQ 495
L + ++D+ IA++ L+ + L + D +ERAAR K ++K L +
Sbjct: 1098 ELQAALARLDD---EIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEE 1154
Query: 496 LAVLLKE 502
L L E
Sbjct: 1155 LEALKTE 1161
Score = 55.8 bits (133), Expect = 1e-07
Identities = 57/243 (23%), Positives = 112/243 (46%), Gaps = 32/243 (13%)
Query: 304 LQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLEL 363
LQVT +E+Q +L + + +++ + + + LE+K+S + E N QE + +L
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911
Query: 364 QVESM----------LSEIKME-QAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTR 412
+ E M L EI E +A+ E+E+ + LQ K+ Q+ + +EE
Sbjct: 912 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ----MLDLEEQLE 967
Query: 413 KESEKVDRAVLKELSEKLELAEKALASKQLQMDEMKQTIAKQ----EEDLETMTILRAQM 468
+E + L++++ + ++ K L + L MD+ ++K+ EE + +T A+
Sbjct: 968 EEEAARQKLQLEKVTAEAKI--KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1025
Query: 469 EVYCSDFHAERAAREKIHEEKEQLALQLAVLLKENDAFEDGGRQSLMEMQSRHGARTSDS 528
E + K+ + E + +L V LK+ E+ RQ L +++ + SD
Sbjct: 1026 EEKAKNL-------TKLKNKHESMISELEVRLKK----EEKSRQELEKLKRKLEGDASDF 1074
Query: 529 DQQ 531
+Q
Sbjct: 1075 HEQ 1077
Score = 55.5 bits (132), Expect = 1e-07
Identities = 70/324 (21%), Positives = 135/324 (41%), Gaps = 54/324 (16%)
Query: 38 EELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERL 97
EE ++Q+++L Q+K+ + A R +E+ A ++ +++ + E + +E L
Sbjct: 1648 EEAIKQLRKLQA---QMKDFQRELEDARASR-DEIFATAKENEKKAKSLEADLMQLQEDL 1703
Query: 98 MALSH-------ENEKLKEELGK-LKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQV-- 147
A E E+L EEL L G++ E ++R+ + E E E++Q +
Sbjct: 1704 AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1763
Query: 148 --VRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTV 205
VR ++A+ L +EL + +++ +E + ++ E + E++
Sbjct: 1764 DRVRKATQQAEQLS--NELATERSTAQKNESARQQLERQNKELRSKLHEME--------- 1812
Query: 206 STGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFE 265
G SK++S A E ++QL E++E +E + +
Sbjct: 1813 --GAVKSKFKSTIAA--------LEAKIAQL----------EEQVEQEAREKQAATKSLK 1852
Query: 266 KKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAEL 325
+K EI Q E DE K E + E N +V L ++L+EA +
Sbjct: 1853 QKDKKLKEILLQVE-------DERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1905
Query: 326 MKKRLQEKCQALERKNSAIPSELN 349
+++LQ + N A+ E+N
Sbjct: 1906 NRRKLQRELDEATESNEAMGREVN 1929
Score = 32.3 bits (72), Expect = 1.2
Identities = 22/79 (27%), Positives = 39/79 (49%), Gaps = 3/79 (3%)
Query: 42 QQMKELLTE-NHQLKEAMKLNNQAMKG--RFEELSAWTEKQKEERQFFEIQSKEAKERLM 98
+++KE+L + + K A + QA KG R ++L E+ +EE Q ++ + L
Sbjct: 1856 KKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELD 1915
Query: 99 ALSHENEKLKEELGKLKGK 117
+ NE + E+ LK K
Sbjct: 1916 EATESNEAMGREVNALKSK 1934
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 83.2 bits (204), Expect = 6e-16
Identities = 121/525 (23%), Positives = 215/525 (40%), Gaps = 68/525 (12%)
Query: 39 ELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTE-----KQKEERQFFEIQSK-- 91
E L+Q K + K+ ++ N + G L + K+K E Q E+QSK
Sbjct: 1210 EQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCS 1269
Query: 92 -------EAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLR 144
E +++ L +E E + L + +GK+ + ++D S QL+
Sbjct: 1270 DGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS-----------SQLQ 1318
Query: 145 TQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRT 204
LQ E L + ++L+ S +D E A+ E + + ++
Sbjct: 1319 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1378
Query: 205 -----VSTGTALSKYRSRSADGAKNY---FEHEELTVSQLLLCLREGNQKVERLEVALKE 256
ST AL + + R +N +E + +L Q+++ L V L
Sbjct: 1379 KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1438
Query: 257 AKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEA 316
++ VS+ EKK ++ + + + K DE E E E L SL + L+EA
Sbjct: 1439 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL---SLARALEEA 1495
Query: 317 HTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESM---LSEIK 373
E E K L+ + + L + ++E ++ + + LE Q+E M L E++
Sbjct: 1496 LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK---SKRALETQMEEMKTQLEELE 1552
Query: 374 MEQAKTEDEKSKLTV------------LQMTHNKLLQEHNNALKTIEEL-TRKESEKVDR 420
E TED K +L V LQ + ++ + + E T E E+ R
Sbjct: 1553 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1612
Query: 421 AVLKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERA 480
A+ +KLE K L +LQ D I +EE ++ + L+AQM+ + + RA
Sbjct: 1613 ALAAAAKKKLEGDLKDL---ELQADS---AIKGREEAIKQLRKLQAQMKDFQRELEDARA 1666
Query: 481 AREKI-----HEEKEQLALQLAVLLKEND--AFEDGGRQSLMEMQ 518
+R++I EK+ +L+ ++ + D A E +Q+ +E +
Sbjct: 1667 SRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKE 1711
Score = 79.0 bits (193), Expect = 1e-14
Identities = 123/601 (20%), Positives = 251/601 (41%), Gaps = 75/601 (12%)
Query: 38 EELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERL 97
E ++ +++ L + + ++ ++ + ++G + + + ++Q + +E L
Sbjct: 1033 ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEEL 1092
Query: 98 MA--------LSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVR 149
A ++ +N LK+ + +L+G ED D R R +AE++K L ++
Sbjct: 1093 QAALARLDDEIAQKNNALKK-IRELEGHISDLQED-LDSERAARNKAEKQKRDLGEELEA 1150
Query: 150 LQAEKADLLGIVS---ELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVS 206
L+ E D L + EL+ K + ++ EA+ KH+ ++
Sbjct: 1151 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA-VEELT 1209
Query: 207 TGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVE----RLEVALKEAKERVS 262
K + D K E E ++ L L + Q+VE +LE ++E + + S
Sbjct: 1210 EQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCS 1269
Query: 263 DFEKKTSNRSE----IETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQE--- 315
D E+ + ++ ++ + E T N+ E + +V +L+ Q+ + LQE
Sbjct: 1270 DGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1329
Query: 316 ----AHTKLSEAELMKKRLQEKC-------QALERKNSAIPSELNEK----QELVYTNKK 360
TKL + E + LQ++ Q LER S + +L++ Q+ T +
Sbjct: 1330 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1389
Query: 361 LELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTR------KE 414
LE + EI+ + E++ + L+ T N+L QE ++ + ++ + K+
Sbjct: 1390 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1449
Query: 415 SEKVDRAVLKELS---------EKLELAEKALASKQLQMDEMKQTIAKQEEDLE-TMTIL 464
K D+ + +E + ++ E + +K L + + + +E+LE T +L
Sbjct: 1450 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1509
Query: 465 RAQMEVYCS-------DFHAERAAREKIHEEKEQLALQLAVLLKENDAFEDGGRQSLMEM 517
+A+ME S + H ++ + + E++ QL L E A ED + + M
Sbjct: 1510 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNM 1569
Query: 518 QSRHG-------ARTSDSDQQAYLVQR-----GAEDRDWRQQRNIPIHSCPKCGEVLPDI 565
Q+ G AR ++++ +QR E D R+QR + + K L D+
Sbjct: 1570 QALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDL 1629
Query: 566 D 566
+
Sbjct: 1630 E 1630
Score = 77.4 bits (189), Expect = 3e-14
Identities = 102/456 (22%), Positives = 189/456 (41%), Gaps = 56/456 (12%)
Query: 78 KQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAE 137
+Q+EE Q E + ++ KER +E ++L+++ +L + E ++ L AEAE
Sbjct: 849 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETEL-YAEAE 907
Query: 138 QEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSG------SSEDSFVEIRMAEGEAEGS 191
+ + VRL A+K +L I+ E++ +L +E + +M + E +
Sbjct: 908 EMR-------VRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 960
Query: 192 VKEIKHSPGPTRTVSTGTALSKYRSR--SADGAKNYFEHE----ELTVSQLLLCLREGNQ 245
+E V+ + K D N E E +S L L E +
Sbjct: 961 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1020
Query: 246 KVERLEVALKEAKERVSDFE----KKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEA 301
K + L + + +S+ E K+ +R E+E +D + + +++
Sbjct: 1021 KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1080
Query: 302 LNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKL 361
L +Q+ +ELQ A +L + K +K + LE S + +L+ ++ K
Sbjct: 1081 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA---ARNKA 1137
Query: 362 ELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDR- 420
E Q + E++ + + ED Q K QE K ++E TR +V
Sbjct: 1138 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1197
Query: 421 -----AVLKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDL--ETMTILRAQMEV--- 470
++EL+E+LE ++A A+ +D+ KQT+ K+ DL E + +A+ EV
Sbjct: 1198 RQKHAQAVEELTEQLEQFKRAKAN----LDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1253
Query: 471 -------------YCSDFHAERA-AREKIHEEKEQL 492
CSD RA +K+H+ + ++
Sbjct: 1254 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1289
Score = 75.9 bits (185), Expect = 1e-13
Identities = 110/538 (20%), Positives = 217/538 (40%), Gaps = 55/538 (10%)
Query: 38 EELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERL 97
EE+L +M+ L E + ++ + M + +L E+++ RQ +++ A+ ++
Sbjct: 921 EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKI 980
Query: 98 MALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADL 157
L E + ++ KL K + E+ D AE E++ L +L+ + +
Sbjct: 981 KKLEDEILVMDDQNNKLS-KERKLLEERISDLTTNLAEEEEKAKNL----TKLKNKHESM 1035
Query: 158 LGIVSELQLKLNSSGSSEDSFVEI-RMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRS 216
+SEL+++L S ++ R EG+A ++I + A +
Sbjct: 1036 ---ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK---KE 1089
Query: 217 RSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEKKTSN------ 270
A + E + L +RE + L+ L + + EK+ +
Sbjct: 1090 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE 1149
Query: 271 --RSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEA----- 323
++E+E + + ++ K + V +AL+ + S ++QE K ++A
Sbjct: 1150 ALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT 1209
Query: 324 ------ELMKKRLQEKCQALERKNSAIPSELN----EKQELVYTNKKLELQVESMLSEI- 372
+ K L + Q LE++N+ + EL KQE+ + KKLE QV+ + S+
Sbjct: 1210 EQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCS 1269
Query: 373 --KMEQAKTEDEKSKL-TVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKE---- 425
+ +A+ D+ KL ++ L + A+K +++ S+ D L +
Sbjct: 1270 DGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1329
Query: 426 ----LSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTI----LRAQMEVYCSDFHA 477
+S KL E+ S Q Q+DE + E + T+ I + +++ + S A
Sbjct: 1330 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1389
Query: 478 ERAAREKIHEEKEQLALQLAVLLKENDAFEDGGRQSLMEMQSRHGARTSDSDQQAYLV 535
+++ +E E L Q +E A D ++ +Q D D Q LV
Sbjct: 1390 LEEGKKRFQKEIENLTQQ----YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLV 1443
Score = 74.3 bits (181), Expect = 3e-13
Identities = 120/544 (22%), Positives = 211/544 (38%), Gaps = 93/544 (17%)
Query: 32 LDTFTPEELLQQMKELLT----ENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFE 87
L+ T E ++++++ + +N++L + KL + + L+ EK K +
Sbjct: 971 LEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1030
Query: 88 IQSKEAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQV 147
E + L E EK ++EL KLK K E + D + +A+ + K QL +
Sbjct: 1031 KHESMISELEVRLKKE-EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1089
Query: 148 VRLQAEKA-----------------DLLGIVSELQLKLNSSGSS--------EDSFVEIR 182
LQA A +L G +S+LQ L+S ++ D E+
Sbjct: 1090 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE 1149
Query: 183 MAEGEAEGSV------KEIKHSPGPTRTVSTGTALSKYRSRSA----------------- 219
+ E E ++ +E++ TV + RS A
Sbjct: 1150 ALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT 1209
Query: 220 -------------DGAKNYFEHEELTVSQLLLCLREGNQKVE----RLEVALKEAKERVS 262
D K E E ++ L L + Q+VE +LE ++E + + S
Sbjct: 1210 EQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCS 1269
Query: 263 DFEKKTSNRSE----IETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHT 318
D E+ + ++ ++ + E T N+ E G ++ L V SL +LQ+
Sbjct: 1270 DGERARAELNDKVHKLQNEVESVTGMLNEAE------GKAIK-LAKDVASLSSQLQDTQE 1322
Query: 319 KLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQAK 378
L E K + K + LE + +++ +L+E+ E + LE + ++ +
Sbjct: 1323 LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEME---AKQNLERHISTL-------NIQ 1372
Query: 379 TEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKLELAEKALA 438
D K KL T L + K IE LT++ EK A +L + ++ L
Sbjct: 1373 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA--AAYDKLEKTKNRLQQELD 1430
Query: 439 SKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAV 498
+ +D +Q ++ E+ L A+ + S + ER E EKE AL LA
Sbjct: 1431 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1490
Query: 499 LLKE 502
L+E
Sbjct: 1491 ALEE 1494
Score = 64.7 bits (156), Expect = 2e-10
Identities = 86/447 (19%), Positives = 185/447 (41%), Gaps = 45/447 (10%)
Query: 38 EELLQQMKELLTENHQLKEAMK---LNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAK 94
EE L+ +EL N LK M+ + + EL + + + + Q +E +
Sbjct: 1493 EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1552
Query: 95 ERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRA-------EAEQEKDQLRTQV 147
+ L A +L+ + LKG+ ER + + + R E E E + R Q
Sbjct: 1553 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1612
Query: 148 VRLQAEKADLLGIVSELQLKLNSS-GSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVS 206
A K L G + +L+L+ +S+ E++ ++R + + + +E++ + +
Sbjct: 1613 ALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIF 1672
Query: 207 TGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERL-EVALKEAKERVSDFE 265
++ +++S + L+ L+E ER + A E +E +
Sbjct: 1673 ATAKENEKKAKSLEAD--------------LMQLQEDLAAAERARKQADLEKEELAEELA 1718
Query: 266 KKTSNRSEIETQTE------GSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTK 319
S R+ ++ + E+E +EE+G +EA++ +V ++ ++ +
Sbjct: 1719 SSLSGRNALQDEKRRLEARIAQLEEELEEEQG------NMEAMSDRVRKATQQAEQLSNE 1772
Query: 320 LSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKK-----LELQVESMLSEIKM 374
L+ ++ + Q LER+N + S+L+E + V + K LE ++ + +++
Sbjct: 1773 LATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ 1832
Query: 375 EQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKLELAE 434
E + + L ++L + + K E+ KE + A +K+L +LE AE
Sbjct: 1833 EAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQY--KEQAEKGNARVKQLKRQLEEAE 1890
Query: 435 KALASKQLQMDEMKQTIAKQEEDLETM 461
+ ++++ + + E E M
Sbjct: 1891 EESQRINANRRKLQRELDEATESNEAM 1917
Score = 63.2 bits (152), Expect = 6e-10
Identities = 79/310 (25%), Positives = 149/310 (48%), Gaps = 44/310 (14%)
Query: 271 RSEIETQT-EGSTEKENDEEKGPETVGSEVEALNLQVT---SLFKELQEAHTKL-SEAEL 325
R E E Q E +K + ++ E E+E + Q+T +L +E +A T+L +EAE
Sbjct: 849 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 908
Query: 326 MKKRLQEKCQALERKNSAIPSELNEK----QELVYTNKKLELQVESMLSEIKME------ 375
M+ RL K Q LE + + L E+ Q+L KK+ Q+ + +++ E
Sbjct: 909 MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 968
Query: 376 --------QAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELS 427
+AK + + ++ V+ +NKL +E + I +LT +E+ ++A K L+
Sbjct: 969 LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA--KNLT 1026
Query: 428 EKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERA-AREKIH 486
KL+ +++ S E++ + K+E+ + + L+ ++E SDFH + A + +I
Sbjct: 1027 -KLKNKHESMIS------ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1079
Query: 487 EEKEQLA-----LQLAVL-LKENDAFEDGGRQSLMEMQSRHGARTSDSDQQAYLVQRGAE 540
E K QLA LQ A+ L + A ++ + + E++ D D +R A
Sbjct: 1080 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS-----ERAAR 1134
Query: 541 DRDWRQQRNI 550
++ +Q+R++
Sbjct: 1135 NKAEKQKRDL 1144
Score = 61.2 bits (147), Expect = 2e-09
Identities = 74/307 (24%), Positives = 131/307 (42%), Gaps = 32/307 (10%)
Query: 212 SKYRSRSADGAKNYFE--HEELTVSQLLL---------CLREGNQKVERLEVALKEAKER 260
+K R + A+ E H +LT + LL E + RL +E +E
Sbjct: 864 TKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEI 923
Query: 261 VSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKL 320
+ + E + + Q + +K + E E EA Q L K EA K
Sbjct: 924 LHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR-QKLQLEKVTAEAKIKK 982
Query: 321 SEAELM-----KKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKME 375
E E++ +L ++ + LE + S + + L E++E KL+ + ESM+SE+++
Sbjct: 983 LEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR 1042
Query: 376 QAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKLELAEK 435
K E + +L L+ KL + ++ + I +L +A + EL +L E+
Sbjct: 1043 LKKEEKSRQELEKLK---RKLEGDASDFHEQIADL---------QAQIAELKMQLAKKEE 1090
Query: 436 ALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERAAREKIHEEKEQLALQ 495
L + ++D+ IA++ L+ + L + D +ERAAR K ++K L +
Sbjct: 1091 ELQAALARLDD---EIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEE 1147
Query: 496 LAVLLKE 502
L L E
Sbjct: 1148 LEALKTE 1154
Score = 55.8 bits (133), Expect = 1e-07
Identities = 57/243 (23%), Positives = 112/243 (46%), Gaps = 32/243 (13%)
Query: 304 LQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLEL 363
LQVT +E+Q +L + + +++ + + + LE+K+S + E N QE + +L
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904
Query: 364 QVESM----------LSEIKME-QAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTR 412
+ E M L EI E +A+ E+E+ + LQ K+ Q+ + +EE
Sbjct: 905 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ----MLDLEEQLE 960
Query: 413 KESEKVDRAVLKELSEKLELAEKALASKQLQMDEMKQTIAKQ----EEDLETMTILRAQM 468
+E + L++++ + ++ K L + L MD+ ++K+ EE + +T A+
Sbjct: 961 EEEAARQKLQLEKVTAEAKI--KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1018
Query: 469 EVYCSDFHAERAAREKIHEEKEQLALQLAVLLKENDAFEDGGRQSLMEMQSRHGARTSDS 528
E + K+ + E + +L V LK+ E+ RQ L +++ + SD
Sbjct: 1019 EEKAKNL-------TKLKNKHESMISELEVRLKK----EEKSRQELEKLKRKLEGDASDF 1067
Query: 529 DQQ 531
+Q
Sbjct: 1068 HEQ 1070
Score = 55.5 bits (132), Expect = 1e-07
Identities = 70/324 (21%), Positives = 135/324 (41%), Gaps = 54/324 (16%)
Query: 38 EELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERL 97
EE ++Q+++L Q+K+ + A R +E+ A ++ +++ + E + +E L
Sbjct: 1641 EEAIKQLRKLQA---QMKDFQRELEDARASR-DEIFATAKENEKKAKSLEADLMQLQEDL 1696
Query: 98 MALSH-------ENEKLKEELGK-LKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQV-- 147
A E E+L EEL L G++ E ++R+ + E E E++Q +
Sbjct: 1697 AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1756
Query: 148 --VRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTV 205
VR ++A+ L +EL + +++ +E + ++ E + E++
Sbjct: 1757 DRVRKATQQAEQLS--NELATERSTAQKNESARQQLERQNKELRSKLHEME--------- 1805
Query: 206 STGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFE 265
G SK++S A E ++QL E++E +E + +
Sbjct: 1806 --GAVKSKFKSTIAA--------LEAKIAQL----------EEQVEQEAREKQAATKSLK 1845
Query: 266 KKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAEL 325
+K EI Q E DE K E + E N +V L ++L+EA +
Sbjct: 1846 QKDKKLKEILLQVE-------DERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1898
Query: 326 MKKRLQEKCQALERKNSAIPSELN 349
+++LQ + N A+ E+N
Sbjct: 1899 NRRKLQRELDEATESNEAMGREVN 1922
Score = 32.3 bits (72), Expect = 1.2
Identities = 22/79 (27%), Positives = 39/79 (49%), Gaps = 3/79 (3%)
Query: 42 QQMKELLTE-NHQLKEAMKLNNQAMKG--RFEELSAWTEKQKEERQFFEIQSKEAKERLM 98
+++KE+L + + K A + QA KG R ++L E+ +EE Q ++ + L
Sbjct: 1849 KKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELD 1908
Query: 99 ALSHENEKLKEELGKLKGK 117
+ NE + E+ LK K
Sbjct: 1909 EATESNEAMGREVNALKSK 1927
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 82.8 bits (203), Expect = 8e-16
Identities = 95/501 (18%), Positives = 219/501 (43%), Gaps = 41/501 (8%)
Query: 32 LDTFTPEELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSK 91
+D + E+ L + + + E + + ++ R +EL A ++ +EER+ Q +
Sbjct: 1924 IDGYADEKTLFERQ--IQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKE 1981
Query: 92 EAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQ 151
K + + + E+L K K + + +E DD + E + ++ ++ + L+
Sbjct: 1982 AMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELE 2041
Query: 152 AEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSV--KEIKHSPGPTRTVSTGT 209
EK L + + L F++ + + E E V +EI+ + V
Sbjct: 2042 QEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQ 2101
Query: 210 ALSKYRSRSADGAKNYFEHEELTVSQLLLC-------LREGNQKVERLEVALKEAKERVS 262
+S++++R + N+ + + S+LLL ++E N+++E+LE ++E ++ +
Sbjct: 2102 PISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALL 2161
Query: 263 DFEKKTSNRSE------IETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEA 316
++K E +E Q + + + +EK + ++E ++ + +E+Q+
Sbjct: 2162 VEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQL 2221
Query: 317 HTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESML------- 369
H +L E+ KK + Q LE++N ++ + + + + Q + +L
Sbjct: 2222 HMQL---EIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQI 2278
Query: 370 ---SEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIE---ELTRKESEKVDRAVL 423
E++++Q + K + + T NK+++E N ++ +E E + E V R
Sbjct: 2279 IQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNRE 2338
Query: 424 KELSEKLELAEKALASKQLQMDEMKQTIAKQEEDL-ETMTILRAQMEVYCSDFHAERAAR 482
+E+ + E+ EK Q ++ + Q + L E L+ Q++V ++ + A
Sbjct: 2339 EEIEQLNEVIEKL----QQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAE---KLALE 2391
Query: 483 EKIHEEKEQLALQLAVLLKEN 503
+++ E++ VL + N
Sbjct: 2392 QQVETANEEMTFMKNVLKETN 2412
Score = 68.6 bits (166), Expect = 2e-11
Identities = 100/504 (19%), Positives = 208/504 (41%), Gaps = 63/504 (12%)
Query: 32 LDTFTPEELLQQMKELLTENHQLKEAMKLNNQA-MKGRFEELSAWTEKQKEERQFFEIQS 90
LD ++++Q +EL+ ++ E MK ++ M+ S T + ++ + +
Sbjct: 437 LDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNE-DQIKLMNVAI 495
Query: 91 KEAKERLMALSHENEKLKEELGKL---KGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQV 147
E +L + + EKLKEELG + K +R ED ++ R + ++ + + Q
Sbjct: 496 NELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQE 555
Query: 148 VRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVST 207
+L E L V +L+ ++ S+ S +E++ E E +++ V
Sbjct: 556 SKLN-EAHKSLSTVEDLKAEIVSASESRKE-LELKH-EAEVTNYKIKLEMLEKEKNAVLD 612
Query: 208 GTALSKYRSRSADGAKNYFEHEELTVSQLLLCLR-EGNQKVERLEVALK-EAKERVSDFE 265
A S+ + F HEE +S+L L E +E+L+ L K+++ +
Sbjct: 613 RMAESQEAELERLRTQLLFSHEE-ELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQ 671
Query: 266 KKTSNRSE-IETQTEGSTEKEND--------EEKGPETVGSEVEALNLQVTSLFKELQEA 316
+ S + E ++ + + K+N ++ V S+ E + LQ+ L KE++
Sbjct: 672 NEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEI- 730
Query: 317 HTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQ 376
L + E K L+++ Q L+ K + ++ EK+ ++ ++++ E
Sbjct: 731 ---LRQEEKEKGTLEQEVQELQLKTELLEKQMKEKEN----------DLQEKFAQLEAEN 777
Query: 377 AKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKLELAEKA 436
+ +DEK L + H + QE L ++ + K + V ++ L E+ E ++
Sbjct: 778 SILKDEKKTLEDMLKIHTPVSQEER--LIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQ 835
Query: 437 LASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERAAREKIHEEKEQLALQL 496
++++ + T + E++ E ++L +
Sbjct: 836 CIQLNEEIEKQRNTFSFAEKNFEV---------------------------NYQELQEEY 868
Query: 497 AVLLKENDAFEDGGRQSLMEMQSR 520
A LLK D ED + +E +S+
Sbjct: 869 ACLLKVKDDLEDSKNKQELEYKSK 892
Score = 66.6 bits (161), Expect = 6e-11
Identities = 97/430 (22%), Positives = 186/430 (43%), Gaps = 49/430 (11%)
Query: 36 TPEELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKE 95
T +LLQ +++LT QL+E L E +++++ F +Q +E
Sbjct: 259 TAADLLQAKQQILTHQQQLEEQDHL---------------LEDYQKKKEDFTMQISFLQE 303
Query: 96 RLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKA 155
++ E +K E K E E T L E+EK L + A+K
Sbjct: 304 KIKVYEMEQDKKVENSNK-----EEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADK- 357
Query: 156 DLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYR 215
LLG + E ++ N ++ +E+ ++ + S +EIK G + K
Sbjct: 358 -LLGELQEQIVQKNQE--IKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRN--HKDS 412
Query: 216 SRSADGAKNYFEHEELTVSQLLLCLRE--GNQKVERLEVALKEAKERVSDFEKKTSNRSE 273
D + + + + QL L E G Q V+ + +++ ++ E KT ++ E
Sbjct: 413 QFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQME--EMKTRHKGE 470
Query: 274 IETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAELMKKR---- 329
+E + +E+ +++ +N+ + L +LQ+ + S+ E +K+
Sbjct: 471 MENALRSYSNITVNED--------QIKLMNVAINELNIKLQDTN---SQKEKLKEELGLI 519
Query: 330 LQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQAKTEDEKSKLTVL 389
L+EKC AL+R+ + EL+ +E + ++ + ES L+E + ED K+++
Sbjct: 520 LEEKC-ALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSA 578
Query: 390 QMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKLELAEKALASKQLQMDEMKQ 449
+ +L +H A T ++ + EK AVL ++E E + L ++ L E +
Sbjct: 579 SESRKELELKH-EAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHE--E 635
Query: 450 TIAKQEEDLE 459
++K +EDLE
Sbjct: 636 ELSKLKEDLE 645
Score = 59.3 bits (142), Expect = 9e-09
Identities = 118/546 (21%), Positives = 226/546 (41%), Gaps = 119/546 (21%)
Query: 55 KEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKL 114
KE L Q + R EEL E+ ++ EIQ KE+ RL L EN+ K+++ KL
Sbjct: 2195 KEITNLEEQLEQFR-EELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKL 2253
Query: 115 KGKSERSSEDPTDDSRLPRA-------EAEQEKDQLRTQVVRLQ------------AEKA 155
+ S T D + E E E DQL QV +LQ EK
Sbjct: 2254 GLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKN 2313
Query: 156 DLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYR 215
+L + +L+ ++ S ++ R E E E + I+ + T+++ +
Sbjct: 2314 EL---IRDLETQIECLMSDQECVK--RNREEEIEQLNEVIEKLQQELANIGQKTSMNAHS 2368
Query: 216 -SRSADGAKNYFE----------------HEELTVSQLLLCLREGNQKVERLEVAL---- 254
S AD K+ + +EE+T + + L+E N K+ +L L
Sbjct: 2369 LSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNV--LKETNFKMNQLTQELFSLK 2426
Query: 255 --KEAKERVSDFEKKTSN---------RSEIET--------QTEGSTEKENDEEKGPETV 295
+E+ E++ + + N + E+E E T ++ EE G ++
Sbjct: 2427 RERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSI 2486
Query: 296 ----------GSEVEALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIP 345
S V A +L++T +K++++ M+++ Q + + L++K +
Sbjct: 2487 INLETRLLQLESTVSAKDLELTQCYKQIKD----------MQEQGQFETEMLQKKIVNLQ 2536
Query: 346 SELNEKQELVYTNKKLELQVESMLSEIKM----EQAKTEDEKSKLTVL-QMTHNKLLQEH 400
+ EK + ++Q+E++ K + +E E++ + L Q+ ++L +
Sbjct: 2537 KIVEEKVAAALVS---QIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDI 2593
Query: 401 NNALKTIEELTRKESEKVDRAVLKELSEKLELAEKALASKQ---------LQMDEMKQTI 451
+ I EL + E +L++ E++E+AEK + K+ L+ +E KQ
Sbjct: 2594 SALTLRISELESQVVEMHTSLILEK--EQVEIAEKNVLEKEKKLLELQKLLEGNEKKQRE 2651
Query: 452 AKQEEDLETMTILRAQMEVYCSD-----FHAERAAREKIHEEKEQLA--------LQLAV 498
+++ + + +L+ E++ S+ F+ A R + K +LA LQ +
Sbjct: 2652 KEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEEL 2711
Query: 499 LLKEND 504
L+KE +
Sbjct: 2712 LVKETN 2717
Score = 50.8 bits (120), Expect = 3e-06
Identities = 113/543 (20%), Positives = 213/543 (39%), Gaps = 60/543 (11%)
Query: 38 EELLQQMKELLTENHQLKEAMKLNNQAMKGR-----FEELSAWTEKQKEERQFFEIQSKE 92
E+L +++K L N QL + ++N+ + EEL A + R+ + +
Sbjct: 1624 EQLQEEIKRL---NRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRN 1680
Query: 93 AKERLMALSHENEKLKEELGKLKGKSERSSEDPTD---DSRLPRAEAEQEKDQLRTQVVR 149
+ + + +++E+ K K + + P + + R +A ++ +VV+
Sbjct: 1681 SSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVK 1740
Query: 150 LQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGP-------- 201
A + +G L +S S S + EAE SVK H
Sbjct: 1741 TTAAVEETIGRHVLGILDRSSKSQSSASLIW----RSEAEASVKSCVHEEHTRVTDESIP 1796
Query: 202 ---------------TRTVSTGTALSKYRSRSA-DGAKNYFEHEELTVSQLLLCLREGNQ 245
++ GT LS+ RS G + E+EEL +L
Sbjct: 1797 SYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEEL----MLNISSRLQA 1852
Query: 246 KVERLEVALKEAKERVSDFE-KKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNL 304
VE+L A+ E ++ + +T E Q + +TE +E+ E + E A
Sbjct: 1853 AVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQ 1912
Query: 305 QVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQ 364
L K E L ++++QEK ++R + N QEL ++ ++Q
Sbjct: 1913 LAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQEL--EAEQQQIQ 1970
Query: 365 VESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLK 424
E L + E K E + +LQ T KL++E ++ E R + +K +A+
Sbjct: 1971 EERELLSRQKEAMKAEAGPVEQQLLQET-EKLMKE-KLEVQCQAEKVRDDLQKQVKALEI 2028
Query: 425 ELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERAAREK 484
++ E++ + K ++ +++Q E+ LE M R ++ D E R+
Sbjct: 2029 DVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKM---RKFLDEQAIDREHE---RDV 2082
Query: 485 IHEEKEQLALQLAVLLKENDAFEDGGRQSLMEMQSRHGARTSDSDQQAYL----VQRGAE 540
+E ++L QL V+ + E R+ +E + H +D + L +QR +
Sbjct: 2083 FQQEIQKLEQQLKVVPRFQPISEHQTRE--VEQLANHLKEKTDKCSELLLSKEQLQRDIQ 2140
Query: 541 DRD 543
+R+
Sbjct: 2141 ERN 2143
Score = 40.8 bits (94), Expect = 0.003
Identities = 74/386 (19%), Positives = 144/386 (37%), Gaps = 54/386 (13%)
Query: 54 LKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGK 113
L E L+ Q M GR L E +K ++ E ++ + +++ + E +K+ +
Sbjct: 3083 LSEIQALHAQ-MNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATE 3141
Query: 114 LKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGS 173
L+ E+ S + + L ++E Q K +L T + +L E++ K +
Sbjct: 3142 LQ---EQLSSEKMVVAEL-KSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHL 3197
Query: 174 SEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTV 233
D+ + E + ++++ K G R+ + S + K L +
Sbjct: 3198 LNDTLASEQKKSRELQWALEKEKAKLG--RSEERDKEELEDLKFSLESQKQRNLQLNLLL 3255
Query: 234 SQLLLCLREGNQKVE------------------RLEVALKEAKERVSDFEKKTSNRSEIE 275
Q L E QK+E L+V L+ K R+ + E+
Sbjct: 3256 EQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELH 3315
Query: 276 TQTEGSTEKENDEEKGP-------------ETVGSEVEALN---------LQVTSLFKEL 313
Q + S P E VE LN LQ ++
Sbjct: 3316 AQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKD 3375
Query: 314 QEAHTKLSEAEL-MKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQ---VESML 369
++ H K + E Q+K L+ K + +L EK++ VY KL+L+ ++ ++
Sbjct: 3376 RQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVY---KLDLEGQRLQGIM 3432
Query: 370 SEIKMEQAKTEDEKSKLTVLQMTHNK 395
E + ++ + E+++ +L N+
Sbjct: 3433 QEFQKQELEREEKRESRRILYQNLNE 3458
Score = 40.8 bits (94), Expect = 0.003
Identities = 82/387 (21%), Positives = 157/387 (40%), Gaps = 66/387 (17%)
Query: 113 KLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSG 172
K+ K E+ SE P+ + E Q ++Q++ +Q E + + +ELQ +L
Sbjct: 3097 KITLKREQESEKPSQEL------LEYNIQQKQSQMLEMQVELSSMKDRATELQEQL---- 3146
Query: 173 SSEDSFV-----EIRMAEGEAEGSVK--------------EIKHSPGPTRTVSTGTALSK 213
SSE V E+ + E E ++K E+K ++ A +
Sbjct: 3147 SSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQ 3206
Query: 214 YRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEKKTSNRSE 273
+SR A E E+ + + +++E L+ +L+ K+R + +
Sbjct: 3207 KKSRELQWA---LEKEKAKLGR---SEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQ 3260
Query: 274 IETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAELMKKRLQEK 333
+ +++ +K + + SE + NL++ L + + ++S ++ L +
Sbjct: 3261 LLNESQ---QKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQ 3317
Query: 334 CQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQAKTEDEKSKLTVLQMTH 393
Q+ + + P +E +L+ K+L+ Q+E S I + E EK KL LQ
Sbjct: 3318 LQSSDGTGQSRPPLPSE--DLL---KELQKQLEEKHSRIV--ELLNETEKYKLDSLQTRQ 3370
Query: 394 N--KLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKLELAEKALASKQLQ-------- 443
K Q H L+T +E + +K + EL K+E ++ L K+ Q
Sbjct: 3371 QMEKDRQVHRKTLQTEQEANTEGQKK-----MHELQSKVEDLQRQLEEKRQQVYKLDLEG 3425
Query: 444 ------MDEMKQTIAKQEEDLETMTIL 464
M E ++ ++EE E+ IL
Sbjct: 3426 QRLQGIMQEFQKQELEREEKRESRRIL 3452
Score = 37.7 bits (86), Expect = 0.029
Identities = 105/512 (20%), Positives = 202/512 (39%), Gaps = 66/512 (12%)
Query: 11 EKEDSPSESTGNG--PPHLAHPNLDTFTPEE---LLQQMKELLTENHQLKEAMKLNNQAM 65
E + ++ TG+ P HL L EE LQ + +L E + ++N +
Sbjct: 1168 ELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDK 1227
Query: 66 KGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSERSSE-- 123
+ + +S E + E Q + + ++ +E + L + K+ EE KL R S+
Sbjct: 1228 ENSGDYIS---ENEDPELQDYRYEVQDFQENMHTLLN---KVTEEYNKLLVLQTRLSKIW 1281
Query: 124 -DPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIR 182
TD +L E K++ T+ + + ++ +L I + KL+S E + +E +
Sbjct: 1282 GQQTDGMKLEFGEENLPKEE--TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQ 1339
Query: 183 MAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLRE 242
+ E E+ +S + + + +NY E E + CL++
Sbjct: 1340 VQELES---------------------LISSLQQQLKETEQNY-EAE-------IHCLQK 1370
Query: 243 GNQKVERLEVALKEAKERV----SDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSE 298
Q V V + V SD ++ S ++ +G+ E + ET +
Sbjct: 1371 RLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEET--NI 1428
Query: 299 VEALNLQVTS-LFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYT 357
V+ L Q L +E+ + +S A + L E S+ + +QE Y
Sbjct: 1429 VKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYF 1488
Query: 358 NKKLELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNN-----------ALKT 406
N+ Q + + K ++E L+ H K + N+ L
Sbjct: 1489 NEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTI 1548
Query: 407 IEELTRKESEKVDR-AVLKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILR 465
EE+ K+ + R ++ E+S A + L + Q+++M+Q + +Q ++ + T L
Sbjct: 1549 SEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELL 1608
Query: 466 AQMEVYCSDFHAERAAREKIHEEKEQLALQLA 497
Q + +R +E++ EE ++L QLA
Sbjct: 1609 RQ--AHMRQMERQREDQEQLQEEIKRLNRQLA 1638
Score = 36.2 bits (82), Expect = 0.084
Identities = 101/501 (20%), Positives = 187/501 (37%), Gaps = 83/501 (16%)
Query: 40 LLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMA 99
LL+Q K+LL E+ Q E+ ++ A +LS + E + E + +E
Sbjct: 3254 LLEQQKQLLNESQQKIESQRMLYDA------QLSEEQGRNLELQVLLESEKVRIREMSST 3307
Query: 100 LSHENEKLKEELGKLKGKSERSSEDPTDD-------------SRLPRAEAEQEKDQLRTQ 146
L E E L +L G + P++D SR+ E EK +L +
Sbjct: 3308 LDRERE-LHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSL 3366
Query: 147 VVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVS 206
R Q EK + Q+ + + +++ E + E + V++++ R
Sbjct: 3367 QTRQQMEK--------DRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQV 3418
Query: 207 TGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEK 266
L R G F+ +EL E +K E + + E +
Sbjct: 3419 YKLDLEGQR---LQGIMQEFQKQEL----------EREEKRESRRILYQNLNEPTT--WS 3463
Query: 267 KTSNRSE---IETQTEGSTEKEN-----DEEKGPETVGSEVEALNLQVTSLFKELQEAHT 318
TS+R+ ++ + EG T++ N + G E+E + ++ + +LQ
Sbjct: 3464 LTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQ 3523
Query: 319 KLSEAELMKKR-------LQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESML-- 369
K SE + +QE + + + + E+ LV + E +L
Sbjct: 3524 KASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQ 3583
Query: 370 -SEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHN--------------NALKTIEELTRKE 414
+E+ ++ +EK+ L + M + ++ + N IE + E
Sbjct: 3584 NAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASE 3643
Query: 415 SEKVDRAVLK-ELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCS 473
E +R L + S K AE +L+ D + QT++ D E +T+ R +Y
Sbjct: 3644 KEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLS---PDSEHVTLKR----IYGK 3696
Query: 474 DFHAERAAREKIHEEKEQLAL 494
AE + I+++K L L
Sbjct: 3697 YLRAESFRKALIYQKKYLLLL 3717
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 81.3 bits (199), Expect = 2e-15
Identities = 96/509 (18%), Positives = 221/509 (43%), Gaps = 49/509 (9%)
Query: 32 LDTFTPEELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSK 91
+D + E+ L + + + E + + ++ R +EL A ++ +EER+ Q +
Sbjct: 1924 IDGYADEKTLFERQ--IQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKE 1981
Query: 92 EAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQ 151
K + + + E+L K K + + +E DD + E + ++ ++ + L+
Sbjct: 1982 AMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELE 2041
Query: 152 AEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSV--KEIKHSPGPTRTVSTGT 209
EK L + + L F++ + + E E V +EI+ + V
Sbjct: 2042 QEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQ 2101
Query: 210 ALSKYRSRSADGAKNYFEHEELTVSQLLLC-------LREGNQKVERLEVALKEAKERV- 261
+S++++R + N+ + + S+LLL ++E N+++E+LE ++E ++ +
Sbjct: 2102 PISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALL 2161
Query: 262 --SDFEKKTSNRS-----------EIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTS 308
+D +K +R +E Q + + + +EK + ++E ++ +
Sbjct: 2162 VSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELEN 2221
Query: 309 LFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESM 368
+E+Q+ H +L E+ KK + Q LE++N ++ + + + + Q + +
Sbjct: 2222 KNEEVQQLHMQL---EIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHV 2278
Query: 369 L----------SEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIE---ELTRKES 415
L E++++Q + K + + T NK+++E N ++ +E E +
Sbjct: 2279 LFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQ 2338
Query: 416 EKVDRAVLKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDL-ETMTILRAQMEVYCSD 474
E V R +E+ + E+ EK Q ++ + Q + L E L+ Q++V ++
Sbjct: 2339 ECVKRNREEEIEQLNEVIEKL----QQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAE 2394
Query: 475 FHAERAAREKIHEEKEQLALQLAVLLKEN 503
+ A +++ E++ VL + N
Sbjct: 2395 ---KLALEQQVETANEEMTFMKNVLKETN 2420
Score = 68.6 bits (166), Expect = 2e-11
Identities = 100/504 (19%), Positives = 208/504 (41%), Gaps = 63/504 (12%)
Query: 32 LDTFTPEELLQQMKELLTENHQLKEAMKLNNQA-MKGRFEELSAWTEKQKEERQFFEIQS 90
LD ++++Q +EL+ ++ E MK ++ M+ S T + ++ + +
Sbjct: 437 LDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNE-DQIKLMNVAI 495
Query: 91 KEAKERLMALSHENEKLKEELGKL---KGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQV 147
E +L + + EKLKEELG + K +R ED ++ R + ++ + + Q
Sbjct: 496 NELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQE 555
Query: 148 VRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVST 207
+L E L V +L+ ++ S+ S +E++ E E +++ V
Sbjct: 556 SKLN-EAHKSLSTVEDLKAEIVSASESRKE-LELKH-EAEVTNYKIKLEMLEKEKNAVLD 612
Query: 208 GTALSKYRSRSADGAKNYFEHEELTVSQLLLCLR-EGNQKVERLEVALK-EAKERVSDFE 265
A S+ + F HEE +S+L L E +E+L+ L K+++ +
Sbjct: 613 RMAESQEAELERLRTQLLFSHEE-ELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQ 671
Query: 266 KKTSNRSE-IETQTEGSTEKEND--------EEKGPETVGSEVEALNLQVTSLFKELQEA 316
+ S + E ++ + + K+N ++ V S+ E + LQ+ L KE++
Sbjct: 672 NEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEI- 730
Query: 317 HTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQ 376
L + E K L+++ Q L+ K + ++ EK+ ++ ++++ E
Sbjct: 731 ---LRQEEKEKGTLEQEVQELQLKTELLEKQMKEKEN----------DLQEKFAQLEAEN 777
Query: 377 AKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKLELAEKA 436
+ +DEK L + H + QE L ++ + K + V ++ L E+ E ++
Sbjct: 778 SILKDEKKTLEDMLKIHTPVSQEER--LIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQ 835
Query: 437 LASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERAAREKIHEEKEQLALQL 496
++++ + T + E++ E ++L +
Sbjct: 836 CIQLNEEIEKQRNTFSFAEKNFEV---------------------------NYQELQEEY 868
Query: 497 AVLLKENDAFEDGGRQSLMEMQSR 520
A LLK D ED + +E +S+
Sbjct: 869 ACLLKVKDDLEDSKNKQELEYKSK 892
Score = 66.6 bits (161), Expect = 6e-11
Identities = 97/430 (22%), Positives = 186/430 (43%), Gaps = 49/430 (11%)
Query: 36 TPEELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKE 95
T +LLQ +++LT QL+E L E +++++ F +Q +E
Sbjct: 259 TAADLLQAKQQILTHQQQLEEQDHL---------------LEDYQKKKEDFTMQISFLQE 303
Query: 96 RLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKA 155
++ E +K E K E E T L E+EK L + A+K
Sbjct: 304 KIKVYEMEQDKKVENSNK-----EEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADK- 357
Query: 156 DLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYR 215
LLG + E ++ N ++ +E+ ++ + S +EIK G + K
Sbjct: 358 -LLGELQEQIVQKNQE--IKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRN--HKDS 412
Query: 216 SRSADGAKNYFEHEELTVSQLLLCLRE--GNQKVERLEVALKEAKERVSDFEKKTSNRSE 273
D + + + + QL L E G Q V+ + +++ ++ E KT ++ E
Sbjct: 413 QFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQME--EMKTRHKGE 470
Query: 274 IETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAELMKKR---- 329
+E + +E+ +++ +N+ + L +LQ+ + S+ E +K+
Sbjct: 471 MENALRSYSNITVNED--------QIKLMNVAINELNIKLQDTN---SQKEKLKEELGLI 519
Query: 330 LQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQAKTEDEKSKLTVL 389
L+EKC AL+R+ + EL+ +E + ++ + ES L+E + ED K+++
Sbjct: 520 LEEKC-ALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSA 578
Query: 390 QMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKLELAEKALASKQLQMDEMKQ 449
+ +L +H A T ++ + EK AVL ++E E + L ++ L E +
Sbjct: 579 SESRKELELKH-EAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHE--E 635
Query: 450 TIAKQEEDLE 459
++K +EDLE
Sbjct: 636 ELSKLKEDLE 645
Score = 59.3 bits (142), Expect = 9e-09
Identities = 118/546 (21%), Positives = 226/546 (41%), Gaps = 119/546 (21%)
Query: 55 KEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKL 114
KE L Q + R EEL E+ ++ EIQ KE+ RL L EN+ K+++ KL
Sbjct: 2203 KEITNLEEQLEQFR-EELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKL 2261
Query: 115 KGKSERSSEDPTDDSRLPRA-------EAEQEKDQLRTQVVRLQ------------AEKA 155
+ S T D + E E E DQL QV +LQ EK
Sbjct: 2262 GLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKN 2321
Query: 156 DLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYR 215
+L + +L+ ++ S ++ R E E E + I+ + T+++ +
Sbjct: 2322 EL---IRDLETQIECLMSDQECVK--RNREEEIEQLNEVIEKLQQELANIGQKTSMNAHS 2376
Query: 216 -SRSADGAKNYFE----------------HEELTVSQLLLCLREGNQKVERLEVAL---- 254
S AD K+ + +EE+T + + L+E N K+ +L L
Sbjct: 2377 LSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNV--LKETNFKMNQLTQELFSLK 2434
Query: 255 --KEAKERVSDFEKKTSN---------RSEIET--------QTEGSTEKENDEEKGPETV 295
+E+ E++ + + N + E+E E T ++ EE G ++
Sbjct: 2435 RERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSI 2494
Query: 296 ----------GSEVEALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIP 345
S V A +L++T +K++++ M+++ Q + + L++K +
Sbjct: 2495 INLETRLLQLESTVSAKDLELTQCYKQIKD----------MQEQGQFETEMLQKKIVNLQ 2544
Query: 346 SELNEKQELVYTNKKLELQVESMLSEIKM----EQAKTEDEKSKLTVL-QMTHNKLLQEH 400
+ EK + ++Q+E++ K + +E E++ + L Q+ ++L +
Sbjct: 2545 KIVEEKVAAALVS---QIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDI 2601
Query: 401 NNALKTIEELTRKESEKVDRAVLKELSEKLELAEKALASKQ---------LQMDEMKQTI 451
+ I EL + E +L++ E++E+AEK + K+ L+ +E KQ
Sbjct: 2602 SALTLRISELESQVVEMHTSLILEK--EQVEIAEKNVLEKEKKLLELQKLLEGNEKKQRE 2659
Query: 452 AKQEEDLETMTILRAQMEVYCSD-----FHAERAAREKIHEEKEQLA--------LQLAV 498
+++ + + +L+ E++ S+ F+ A R + K +LA LQ +
Sbjct: 2660 KEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEEL 2719
Query: 499 LLKEND 504
L+KE +
Sbjct: 2720 LVKETN 2725
Score = 50.8 bits (120), Expect = 3e-06
Identities = 113/543 (20%), Positives = 213/543 (39%), Gaps = 60/543 (11%)
Query: 38 EELLQQMKELLTENHQLKEAMKLNNQAMKGR-----FEELSAWTEKQKEERQFFEIQSKE 92
E+L +++K L N QL + ++N+ + EEL A + R+ + +
Sbjct: 1624 EQLQEEIKRL---NRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRN 1680
Query: 93 AKERLMALSHENEKLKEELGKLKGKSERSSEDPTD---DSRLPRAEAEQEKDQLRTQVVR 149
+ + + +++E+ K K + + P + + R +A ++ +VV+
Sbjct: 1681 SSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVK 1740
Query: 150 LQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGP-------- 201
A + +G L +S S S + EAE SVK H
Sbjct: 1741 TTAAVEETIGRHVLGILDRSSKSQSSASLIW----RSEAEASVKSCVHEEHTRVTDESIP 1796
Query: 202 ---------------TRTVSTGTALSKYRSRSA-DGAKNYFEHEELTVSQLLLCLREGNQ 245
++ GT LS+ RS G + E+EEL +L
Sbjct: 1797 SYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEEL----MLNISSRLQA 1852
Query: 246 KVERLEVALKEAKERVSDFE-KKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNL 304
VE+L A+ E ++ + +T E Q + +TE +E+ E + E A
Sbjct: 1853 AVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQ 1912
Query: 305 QVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQ 364
L K E L ++++QEK ++R + N QEL ++ ++Q
Sbjct: 1913 LAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQEL--EAEQQQIQ 1970
Query: 365 VESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLK 424
E L + E K E + +LQ T KL++E ++ E R + +K +A+
Sbjct: 1971 EERELLSRQKEAMKAEAGPVEQQLLQET-EKLMKE-KLEVQCQAEKVRDDLQKQVKALEI 2028
Query: 425 ELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERAAREK 484
++ E++ + K ++ +++Q E+ LE M R ++ D E R+
Sbjct: 2029 DVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKM---RKFLDEQAIDREHE---RDV 2082
Query: 485 IHEEKEQLALQLAVLLKENDAFEDGGRQSLMEMQSRHGARTSDSDQQAYL----VQRGAE 540
+E ++L QL V+ + E R+ +E + H +D + L +QR +
Sbjct: 2083 FQQEIQKLEQQLKVVPRFQPISEHQTRE--VEQLANHLKEKTDKCSELLLSKEQLQRDIQ 2140
Query: 541 DRD 543
+R+
Sbjct: 2141 ERN 2143
Score = 40.8 bits (94), Expect = 0.003
Identities = 74/386 (19%), Positives = 144/386 (37%), Gaps = 54/386 (13%)
Query: 54 LKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGK 113
L E L+ Q M GR L E +K ++ E ++ + +++ + E +K+ +
Sbjct: 3091 LSEIQALHAQ-MNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATE 3149
Query: 114 LKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGS 173
L+ E+ S + + L ++E Q K +L T + +L E++ K +
Sbjct: 3150 LQ---EQLSSEKMVVAEL-KSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHL 3205
Query: 174 SEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTV 233
D+ + E + ++++ K G R+ + S + K L +
Sbjct: 3206 LNDTLASEQKKSRELQWALEKEKAKLG--RSEERDKEELEDLKFSLESQKQRNLQLNLLL 3263
Query: 234 SQLLLCLREGNQKVE------------------RLEVALKEAKERVSDFEKKTSNRSEIE 275
Q L E QK+E L+V L+ K R+ + E+
Sbjct: 3264 EQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELH 3323
Query: 276 TQTEGSTEKENDEEKGP-------------ETVGSEVEALN---------LQVTSLFKEL 313
Q + S P E VE LN LQ ++
Sbjct: 3324 AQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKD 3383
Query: 314 QEAHTKLSEAEL-MKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQ---VESML 369
++ H K + E Q+K L+ K + +L EK++ VY KL+L+ ++ ++
Sbjct: 3384 RQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVY---KLDLEGQRLQGIM 3440
Query: 370 SEIKMEQAKTEDEKSKLTVLQMTHNK 395
E + ++ + E+++ +L N+
Sbjct: 3441 QEFQKQELEREEKRESRRILYQNLNE 3466
Score = 40.8 bits (94), Expect = 0.003
Identities = 82/387 (21%), Positives = 157/387 (40%), Gaps = 66/387 (17%)
Query: 113 KLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSG 172
K+ K E+ SE P+ + E Q ++Q++ +Q E + + +ELQ +L
Sbjct: 3105 KITLKREQESEKPSQEL------LEYNIQQKQSQMLEMQVELSSMKDRATELQEQL---- 3154
Query: 173 SSEDSFV-----EIRMAEGEAEGSVK--------------EIKHSPGPTRTVSTGTALSK 213
SSE V E+ + E E ++K E+K ++ A +
Sbjct: 3155 SSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQ 3214
Query: 214 YRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEKKTSNRSE 273
+SR A E E+ + + +++E L+ +L+ K+R + +
Sbjct: 3215 KKSRELQWA---LEKEKAKLGR---SEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQ 3268
Query: 274 IETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAELMKKRLQEK 333
+ +++ +K + + SE + NL++ L + + ++S ++ L +
Sbjct: 3269 LLNESQ---QKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQ 3325
Query: 334 CQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQAKTEDEKSKLTVLQMTH 393
Q+ + + P +E +L+ K+L+ Q+E S I + E EK KL LQ
Sbjct: 3326 LQSSDGTGQSRPPLPSE--DLL---KELQKQLEEKHSRIV--ELLNETEKYKLDSLQTRQ 3378
Query: 394 N--KLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKLELAEKALASKQLQ-------- 443
K Q H L+T +E + +K + EL K+E ++ L K+ Q
Sbjct: 3379 QMEKDRQVHRKTLQTEQEANTEGQKK-----MHELQSKVEDLQRQLEEKRQQVYKLDLEG 3433
Query: 444 ------MDEMKQTIAKQEEDLETMTIL 464
M E ++ ++EE E+ IL
Sbjct: 3434 QRLQGIMQEFQKQELEREEKRESRRIL 3460
Score = 37.7 bits (86), Expect = 0.029
Identities = 105/512 (20%), Positives = 202/512 (39%), Gaps = 66/512 (12%)
Query: 11 EKEDSPSESTGNG--PPHLAHPNLDTFTPEE---LLQQMKELLTENHQLKEAMKLNNQAM 65
E + ++ TG+ P HL L EE LQ + +L E + ++N +
Sbjct: 1168 ELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDK 1227
Query: 66 KGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSERSSE-- 123
+ + +S E + E Q + + ++ +E + L + K+ EE KL R S+
Sbjct: 1228 ENSGDYIS---ENEDPELQDYRYEVQDFQENMHTLLN---KVTEEYNKLLVLQTRLSKIW 1281
Query: 124 -DPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIR 182
TD +L E K++ T+ + + ++ +L I + KL+S E + +E +
Sbjct: 1282 GQQTDGMKLEFGEENLPKEE--TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQ 1339
Query: 183 MAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLRE 242
+ E E+ +S + + + +NY E E + CL++
Sbjct: 1340 VQELES---------------------LISSLQQQLKETEQNY-EAE-------IHCLQK 1370
Query: 243 GNQKVERLEVALKEAKERV----SDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSE 298
Q V V + V SD ++ S ++ +G+ E + ET +
Sbjct: 1371 RLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEET--NI 1428
Query: 299 VEALNLQVTS-LFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYT 357
V+ L Q L +E+ + +S A + L E S+ + +QE Y
Sbjct: 1429 VKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYF 1488
Query: 358 NKKLELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNN-----------ALKT 406
N+ Q + + K ++E L+ H K + N+ L
Sbjct: 1489 NEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTI 1548
Query: 407 IEELTRKESEKVDR-AVLKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILR 465
EE+ K+ + R ++ E+S A + L + Q+++M+Q + +Q ++ + T L
Sbjct: 1549 SEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELL 1608
Query: 466 AQMEVYCSDFHAERAAREKIHEEKEQLALQLA 497
Q + +R +E++ EE ++L QLA
Sbjct: 1609 RQ--AHMRQMERQREDQEQLQEEIKRLNRQLA 1638
Score = 36.2 bits (82), Expect = 0.084
Identities = 101/501 (20%), Positives = 187/501 (37%), Gaps = 83/501 (16%)
Query: 40 LLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMA 99
LL+Q K+LL E+ Q E+ ++ A +LS + E + E + +E
Sbjct: 3262 LLEQQKQLLNESQQKIESQRMLYDA------QLSEEQGRNLELQVLLESEKVRIREMSST 3315
Query: 100 LSHENEKLKEELGKLKGKSERSSEDPTDD-------------SRLPRAEAEQEKDQLRTQ 146
L E E L +L G + P++D SR+ E EK +L +
Sbjct: 3316 LDRERE-LHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSL 3374
Query: 147 VVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVS 206
R Q EK + Q+ + + +++ E + E + V++++ R
Sbjct: 3375 QTRQQMEK--------DRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQV 3426
Query: 207 TGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEK 266
L R G F+ +EL E +K E + + E +
Sbjct: 3427 YKLDLEGQR---LQGIMQEFQKQEL----------EREEKRESRRILYQNLNEPTT--WS 3471
Query: 267 KTSNRSE---IETQTEGSTEKEN-----DEEKGPETVGSEVEALNLQVTSLFKELQEAHT 318
TS+R+ ++ + EG T++ N + G E+E + ++ + +LQ
Sbjct: 3472 LTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQ 3531
Query: 319 KLSEAELMKKR-------LQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESML-- 369
K SE + +QE + + + + E+ LV + E +L
Sbjct: 3532 KASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQ 3591
Query: 370 -SEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHN--------------NALKTIEELTRKE 414
+E+ ++ +EK+ L + M + ++ + N IE + E
Sbjct: 3592 NAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASE 3651
Query: 415 SEKVDRAVLK-ELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCS 473
E +R L + S K AE +L+ D + QT++ D E +T+ R +Y
Sbjct: 3652 KEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLS---PDSEHVTLKR----IYGK 3704
Query: 474 DFHAERAAREKIHEEKEQLAL 494
AE + I+++K L L
Sbjct: 3705 YLRAESFRKALIYQKKYLLLL 3725
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 80.9 bits (198), Expect = 3e-15
Identities = 87/436 (19%), Positives = 193/436 (44%), Gaps = 36/436 (8%)
Query: 38 EELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQK----------EERQFFE 87
+ L +Q KEL + +L+E KL Q + + +E W +++K +E + +E
Sbjct: 283 KRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWE 342
Query: 88 IQSKEAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQV 147
Q K+ +E+ + + E++ E+ +L+ K ER E + + E QE++++R +
Sbjct: 343 -QEKQMREQEQKMRDQEERMWEQDERLREKEERMRE---QEKMWEQEEKMQEEERIRERE 398
Query: 148 VRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVST 207
+++ E+ + ++Q + + E+ + + + E ++ K +
Sbjct: 399 KKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQ 458
Query: 208 GTALSKYRSRSADGAKNY----FEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSD 263
+ K + +E + + +R+ QK+ E + E ER+ +
Sbjct: 459 EEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLRE 518
Query: 264 FEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEA 323
E++ + ++ Q E E++ +E+ +T E E + + + ++E K+ E
Sbjct: 519 KEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQE-EKMREE-----ERMREREKKMREE 572
Query: 324 ELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESML-SEIKMEQAKTEDE 382
E M + +EK Q E K ++ E++E K++ Q E M E KM + + ED+
Sbjct: 573 EEMMREQEEKMQEQEEKMREQEEKMWEQEE------KMQEQEEKMWEQEEKMWEQEEEDK 626
Query: 383 KSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKLELAEKALASKQL 442
+ + + +QE + EE R++ EK ++E EK++ E+ + ++
Sbjct: 627 MQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEK-----MREQEEKMQGQEEKMREQEE 681
Query: 443 QMDEMKQTIAKQEEDL 458
+M ++ + +QEE +
Sbjct: 682 KMQGQEEKMREQEEKM 697
Score = 78.6 bits (192), Expect = 1e-14
Identities = 102/532 (19%), Positives = 224/532 (42%), Gaps = 64/532 (12%)
Query: 40 LLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMA 99
LL Q++ + ++ +L Q K R +E W ++++ Q +++ +E K R
Sbjct: 223 LLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQE 282
Query: 100 --LSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADL 157
L + ++L+E+ +L+ E+ +LR Q ++Q ++ +
Sbjct: 283 KRLREQEKELREQEKELR-----------------------EQKKLREQEEQMQEQEEKM 319
Query: 158 LGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSR 217
+++ + E+ R+ E E + +E K R L + R
Sbjct: 320 WEQEEKMREQEEKMWRQEE-----RLWEQEKQMREQEQKMRDQEERMWEQDERLREKEER 374
Query: 218 SADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEKKTSNRSEIETQ 277
+ K + + E++ + +RE +K+ E ++E +E++ E+ + E E Q
Sbjct: 375 MREQEKMWEQEEKMQEEER---IREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQ 431
Query: 278 TEGSTEKEN---DEEK---GPETVGSEVEALNLQVTSLFKE--------LQEAHTKLSEA 323
+ E++ ++EK E + + E + Q +E ++E ++ E
Sbjct: 432 QQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQ 491
Query: 324 ELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKM--EQAKTED 381
E + ++K E + L EK+E + KK+ Q E M E K ++ KT D
Sbjct: 492 EEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWD 551
Query: 382 EKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKLELAEKALASKQ 441
++ K M + ++E ++ EE+ R++ EK ++E EK+ E+ + ++
Sbjct: 552 QEEK-----MREEERMREREKKMREEEEMMREQEEK-----MQEQEEKMREQEEKMWEQE 601
Query: 442 LQMDEMKQTIAKQEEDL---ETMTILRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAV 498
+M E ++ + +QEE + E ++ Q E+ + EK+ E++E++ Q
Sbjct: 602 EKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEK 661
Query: 499 LLKENDAFEDGGRQSLMEMQSRHGARTSDSDQQAYLVQRGAEDRDWRQQRNI 550
+ ++ + + G++ M Q + ++ RG E++ W Q+ +
Sbjct: 662 MREQEEKMQ--GQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKM 711
Score = 59.7 bits (143), Expect = 7e-09
Identities = 84/451 (18%), Positives = 187/451 (41%), Gaps = 44/451 (9%)
Query: 135 EAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKE 194
E +E+D L ++ R +L +ELQ KL + S + EI++ E + ++
Sbjct: 163 ELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKS---EIQLNVKELKRKLER 219
Query: 195 IKHSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLC------LREGNQKVE 248
K +T + + + + K + EE Q +RE +K+
Sbjct: 220 AKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMR 279
Query: 249 RLEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTS 308
R E L+E ++ + + EK+ + ++ Q E E+E + E + + E + Q
Sbjct: 280 RQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEER 339
Query: 309 LFKE------------------------LQEAHTKLSEAELMKKRLQEKCQALERKNSAI 344
L+++ L+E ++ E E M ++ +EK Q ER
Sbjct: 340 LWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQ-EEKMQEEERIRERE 398
Query: 345 PSELNEKQELVYTNKKLELQVESM--LSEIKMEQAKTEDEKSKLTVLQ--MTHNKLLQEH 400
E++ + +K++ Q E+M E + +Q + ++K KL + + + E
Sbjct: 399 KKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQ 458
Query: 401 NNALKTIEELTRKESEKVDRAVLKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDL-E 459
++ EE+ +E + + ++E +++ E+ + ++ +M + ++ + +Q+E L E
Sbjct: 459 EEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLRE 518
Query: 460 TMTILRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAVLLKENDAFEDGGRQSLMEMQS 519
+R Q +++ + E+ EK +E+E+ ++E + + R+ M +
Sbjct: 519 KEERMREQKKMWQQE---EKMREEKKTQEQEKKTWDQEEKMREEERMRE--REKKMREEE 573
Query: 520 RHGARTSDSDQQAYLVQRGAEDRDWRQQRNI 550
+ Q+ R E++ W Q+ +
Sbjct: 574 EMMREQEEKMQEQEEKMREQEEKMWEQEEKM 604
Score = 57.4 bits (137), Expect = 4e-08
Identities = 85/415 (20%), Positives = 172/415 (41%), Gaps = 27/415 (6%)
Query: 38 EELLQQMKELLTENHQLKEA---MKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSK--- 91
E++ +Q + L + Q++E M+ + M + E L E+ +E+ + +E + K
Sbjct: 331 EKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQE 390
Query: 92 --EAKERLMALSHENEKLKEELGKLKGKSER---SSEDPTDDSRLPRAEA---EQEKDQL 143
+ER + E E ++E+ K++ + E E RLP + EQEK Q
Sbjct: 391 EERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQE 450
Query: 144 RTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTR 203
+ + + Q EK + + K+ + E +M E E + +E K R
Sbjct: 451 QEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQ--EDQMWEQEEKMRDQEQKMWDQEER 508
Query: 204 TVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSD 263
L + R + K + + E++ + +E +K E ++E +ER+ +
Sbjct: 509 MWEQDERLREKEERMREQKKMWQQEEKMREEKKT---QEQEKKTWDQEEKMRE-EERMRE 564
Query: 264 FEKKTSNRSE-IETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKE-----LQEAH 317
EKK E + Q E E+E + E + + E + Q ++++ QE
Sbjct: 565 REKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEE 624
Query: 318 TKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQE-LVYTNKKLELQVESMLSEIKMEQ 376
K+ E E M +EK Q E K ++ E++E + +K++ Q E M + + Q
Sbjct: 625 DKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQ 684
Query: 377 AKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKLE 431
+ E + + ++ K+ + E++ +E + +++ EK++
Sbjct: 685 GQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQ 739
Score = 45.4 bits (106), Expect = 1e-04
Identities = 69/349 (19%), Positives = 140/349 (40%), Gaps = 54/349 (15%)
Query: 254 LKEAKERVSDF----------------EKKTSNRSEIETQTEGSTEKENDEEKGP----E 293
L EAK++ +D+ +KK +N + ET T DE+K E
Sbjct: 22 LAEAKKKFTDYRQWNIAGVGTRATDTKKKKINNGTNPETTTSEGCHSPEDEKKASHQHQE 81
Query: 294 TVGSEVEA-------LNLQVTSLFKEL---QEAHTK-----LSEAELMKKRLQEKCQ--- 335
+ E+EA L Q T L L Q+A K L E++ + RL
Sbjct: 82 ALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDGNLGESKDLAGRLHHSWHFAG 141
Query: 336 ALERKNSAIPS----------ELNEKQELV----YTNKKLELQVESMLSEIKMEQAKTED 381
L+R SA+ + EL ++++ + Y N +++ +E++ + E
Sbjct: 142 ELQRALSAVSTWHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAES 201
Query: 382 EKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKLELAEKALASKQ 441
EKS++ + + L+ L ++ T +E L+E +K+ E+ + ++
Sbjct: 202 EKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQE 261
Query: 442 LQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAVLLK 501
++ E + + +QEE + + E + E ++K+ E++EQ+ Q + +
Sbjct: 262 ERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWE 321
Query: 502 ENDAFEDGGRQSLMEMQSRHGARTSDSDQQAYLVQRGAEDRDWRQQRNI 550
+ + + + + + R + +Q + R E+R W Q +
Sbjct: 322 QEEKMRE-QEEKMWRQEERLWEQEKQMREQEQKM-RDQEERMWEQDERL 368
Score = 42.4 bits (98), Expect = 0.001
Identities = 62/301 (20%), Positives = 126/301 (41%), Gaps = 31/301 (10%)
Query: 38 EELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKER- 96
EE+ Q K++ + ++ ++ Q K R +E W ++++ Q ++ KE + R
Sbjct: 466 EEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMRE 525
Query: 97 LMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEK------DQLRTQVVRL 150
+ + EK++EE K + E+ + D + R E+EK + +R Q ++
Sbjct: 526 QKKMWQQEEKMREE--KKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKM 583
Query: 151 QAEKADLLGIVSELQLKLNSSGSSEDSF--VEIRMAEGEAEGSVKEIKHSPGPTRTVSTG 208
Q ++ + ++ + E+ E +M E E E ++E +
Sbjct: 584 QEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEE----------- 632
Query: 209 TALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEKKT 268
+ + + + + +E EE Q +RE +K++ E ++E +E++ E+K
Sbjct: 633 -MMWEQEEKMQEQEEKMWEQEEKMREQEEK-MREQEEKMQGQEEKMREQEEKMQGQEEKM 690
Query: 269 SNRSE----IETQTEGSTEKE-NDEEK--GPETVGSEVEALNLQVTSLFKELQEAHTKLS 321
+ E E + G EK EEK G E + + E + Q + + L E + S
Sbjct: 691 REQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPEHEERCS 750
Query: 322 E 322
E
Sbjct: 751 E 751
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 80.5 bits (197), Expect = 4e-15
Identities = 98/427 (22%), Positives = 181/427 (42%), Gaps = 40/427 (9%)
Query: 40 LLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSA---WTEKQKEERQFF--EIQSKEAK 94
L ++K LL + Q +E M + +K R ++L+A TE + + Q ++Q +E
Sbjct: 830 LFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQL 889
Query: 95 ERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEK 154
+ L E E+L+ L K + E D EA E+++ R Q LQAEK
Sbjct: 890 QAETELCAEAEELRARLTAKKQELEEICHD---------LEARVEEEEERCQ--HLQAEK 938
Query: 155 ADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSK- 213
+ + EL+ +L S+ ++++ + E +K+++ + A K
Sbjct: 939 KKMQQNIQELEEQLEEEESARQ---KLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKK 995
Query: 214 -YRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEKKTSNRS 272
R A+ N E EE + S L + E + + +ER+ EK+
Sbjct: 996 LLEDRIAEFTTNLTEEEEKSKSLAKL--------KNKHEAMITDLEERLRREEKQRQELE 1047
Query: 273 EIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAELMKKRLQE 332
+ + EG + +D+ + +++ L +Q+ +ELQ A ++ E K +
Sbjct: 1048 KTRRKLEGDSTDLSDQIA---ELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALK 1104
Query: 333 KCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQAKTEDEKSKLTVLQMT 392
K + LE + S + +L ++ + K E Q + E++ + + ED Q
Sbjct: 1105 KIRELESQISELQEDLESERA---SRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQEL 1161
Query: 393 HNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKLELAEKALASKQLQMDEMKQTIA 452
+K QE N KT+E E K A ++E+ +K A + LA + Q +K +
Sbjct: 1162 RSKREQEVNILKKTLE-----EEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLE 1216
Query: 453 KQEEDLE 459
K ++ LE
Sbjct: 1217 KAKQTLE 1223
Score = 74.7 bits (182), Expect = 2e-13
Identities = 126/572 (22%), Positives = 233/572 (40%), Gaps = 86/572 (15%)
Query: 38 EELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQS------- 90
EE+ ++ + E + + ++ + M+ +EL E+++ RQ +++
Sbjct: 914 EEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKL 973
Query: 91 KEAKERLMALSHENEKLKEE------------------------LGKLKGKSERSSEDPT 126
K+ +E + L +N KL +E L KLK K E D
Sbjct: 974 KKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDL- 1032
Query: 127 DDSRLPRAEAEQEKDQLRTQVVRLQAEKADLLGIVSELQ-----LKLNSSGSSEDSFVEI 181
+ RL R E+++ +L +L+ + DL ++ELQ LK+ + E+ +
Sbjct: 1033 -EERLRR--EEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAAL 1089
Query: 182 RMAEGEA-------------EGSVKEIKHSPGPTRTV---------STGTALSKYRSRSA 219
E EA E + E++ R G L ++
Sbjct: 1090 ARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELE 1149
Query: 220 DGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEKKTSNR-SEIETQT 278
D + +EL + +E N + LE K + ++ + +K S E+ Q
Sbjct: 1150 DTLDSTAAQQELRSKR----EQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQL 1205
Query: 279 EGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALE 338
E + + + EK +T+ +E L +V L + ++ K + E + LQ K E
Sbjct: 1206 EQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGE 1265
Query: 339 RKNSAIPSELNEKQELVYTNKKLEL-QVESMLSEIKMEQAK-TEDEKSKLTVLQMTHNKL 396
R + +EL +K T ++EL V +LS+ + +K T+D + + LQ T L
Sbjct: 1266 R----VRTELADK----VTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELL 1317
Query: 397 LQEHNNALKTIEELTRKESEKVD-RAVLKELSEKLELAEKALASKQLQMDEMKQTIAKQE 455
+E+ L +L + E EK R L+E E EK +A+ Q+ +MK+ +
Sbjct: 1318 QEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSV 1377
Query: 456 EDLETMTILRAQME---VYCSDFHAER-AAREKIHEEKEQLALQLAVLLKENDAFEDGGR 511
LET ++ +++ S H E+ AA +K+ + K +L +L LL + D R
Sbjct: 1378 GCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVD----LDHQR 1433
Query: 512 QSLMEMQSRHGARTSDSDQQAYLVQRGAEDRD 543
QS ++ + ++ + + AE+RD
Sbjct: 1434 QSACNLEKKQKKFDQLLAEEKTISAKYAEERD 1465
Score = 66.2 bits (160), Expect = 8e-11
Identities = 101/496 (20%), Positives = 193/496 (38%), Gaps = 80/496 (16%)
Query: 38 EELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERL 97
E LQ +ELL E ++ K ++ + ++ +E +++ E+ +EE + K+
Sbjct: 1307 ESQLQDTQELLQEENRQKLSLSTKLKQVE---DEKNSFREQLEEEEEAKHNLEKQIATLH 1363
Query: 98 MALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEK--DQLRTQVVRLQAEKA 155
++ +K+++ +G L+ E + D L + E+ D+L RLQ E
Sbjct: 1364 AQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELD 1423
Query: 156 DLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYR 215
DLL + + + + F ++ E +T+S A + R
Sbjct: 1424 DLLVDLDHQRQSACNLEKKQKKFDQLLAEE-----------------KTISAKYAEERDR 1466
Query: 216 SRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEKKTSNRSEIE 275
+ + RE K L AL+EA E+ ++ E+ +
Sbjct: 1467 AEAE--------------------AREKETKALSLARALEEAMEQKAELERLNK---QFR 1503
Query: 276 TQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQ 335
T+ E ++D K + AL QV + +L+E +L E K RL+ Q
Sbjct: 1504 TEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQ 1563
Query: 336 ALERK--------------------------NSAIPSELNEKQELVYTNKKLELQVESML 369
A++ + + + E ++ V KKLE+ ++ +
Sbjct: 1564 AMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLE 1623
Query: 370 SEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEEL--TRKESEKVDR---AVLK 424
+ I ++ +L LQ ++E ++ + EE+ KE+EK + A +
Sbjct: 1624 AHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMI 1683
Query: 425 ELSEKLELAEKALASKQLQMDEMKQTIA----KQEEDLETMTILRAQMEVYCSDFHAERA 480
+L E+L AE+A Q + DE+ IA K LE L A++ + E+
Sbjct: 1684 QLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQG 1743
Query: 481 AREKIHEEKEQLALQL 496
E I++ ++ LQ+
Sbjct: 1744 NTELINDRLKKANLQI 1759
Score = 63.2 bits (152), Expect = 6e-10
Identities = 93/452 (20%), Positives = 202/452 (44%), Gaps = 60/452 (13%)
Query: 38 EELLQQMKELLTENHQLKEAMK--LNNQAMKGR----FEELSAWTEKQKEERQFFEIQSK 91
EE ++Q EL N Q + M+ ++++ G+ E+ E+Q EE + Q +
Sbjct: 1486 EEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEE---MKTQLE 1542
Query: 92 EAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQ 151
E ++ L A +L+ L +K + ER + + S E++K QL QV ++
Sbjct: 1543 ELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQS-------EEKKKQLVRQVREME 1595
Query: 152 AEKAD-----LLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVS 206
AE D + + + +L+++ +D I A + ++K+++
Sbjct: 1596 AELEDERKQRSMAVAARKKLEMDL----KDLEAHIDSANKNRDEAIKQLR---------- 1641
Query: 207 TGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEK 266
K +++ D + + + ++L +E +K++ +E + + +E ++ E+
Sbjct: 1642 ------KLQAQMKDCMRE-LDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAER 1694
Query: 267 KTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQE--AHTKLSEAE 324
+ R + + E + E N KG + E L ++ L +EL+E +T+L
Sbjct: 1695 --AKRQAQQERDELADEIANSSGKGALAL-EEKRRLEARIAQLEEELEEEQGNTELINDR 1751
Query: 325 LMKKRLQ--EKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQAKTEDE 382
L K LQ + L + S N +Q+L NK+L+++++ M +K +
Sbjct: 1752 LKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKY------ 1805
Query: 383 KSKLTVLQMTHNKLLQEHNNALKTIEELTR--KESEKVDRAVLKELSEKLELAE--KALA 438
K+ +T L+ +L ++ +N K + + + +EK + VL ++ ++ AE K A
Sbjct: 1806 KASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQA 1865
Query: 439 SK-QLQMDEMKQTIAKQEEDLETMTILRAQME 469
K ++ ++K+ + + EE+ + R +++
Sbjct: 1866 DKASTRLKQLKRQLEEAEEEAQRANASRRKLQ 1897
Score = 54.3 bits (129), Expect = 3e-07
Identities = 65/338 (19%), Positives = 149/338 (44%), Gaps = 57/338 (16%)
Query: 28 AHPNLDTFTPEELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFE 87
AH + +E ++Q+++L Q+K+ M+ + R EE+ A ++ +++ + E
Sbjct: 1624 AHIDSANKNRDEAIKQLRKLQA---QMKDCMRELDDTRASR-EEILAQAKENEKKLKSME 1679
Query: 88 IQSKEAKERLMALSH-------ENEKLKEELGKLKGKSERSSEDPTD-DSRLPRAEAEQE 139
+ + +E L A E ++L +E+ GK + E+ ++R+ + E E E
Sbjct: 1680 AEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELE 1739
Query: 140 KDQLRTQVVRLQAEKADLL--GIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKH 197
++Q T+++ + +KA+L I ++L L+ + + +E++ ++ E + ++E++
Sbjct: 1740 EEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEME- 1798
Query: 198 SPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEA 257
GT SKY++ E ++QL E+L+ KE
Sbjct: 1799 ----------GTVKSKYKAS--------ITALEAKIAQL----------EEQLDNETKER 1830
Query: 258 KERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAH 317
+ + ++ Q + DE + E + + + ++ L ++L+EA
Sbjct: 1831 QAACKQVRRTEKKLKDVLLQVD-------DERRNAEQYKDQADKASTRLKQLKRQLEEAE 1883
Query: 318 TKLSEAELMKKRLQ-------EKCQALERKNSAIPSEL 348
+ A +++LQ E A+ R+ S++ ++L
Sbjct: 1884 EEAQRANASRRKLQRELEDATETADAMNREVSSLKNKL 1921
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 79.7 bits (195), Expect = 7e-15
Identities = 111/487 (22%), Positives = 215/487 (44%), Gaps = 80/487 (16%)
Query: 39 ELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLM 98
E Q++KE L+E ++ Q +K F++L ++Q+EE++ +Q + +L
Sbjct: 372 EATQKLKEELSE-------VETKYQHLKAEFKQL----QQQREEKEQHGLQLQSEINQLH 420
Query: 99 ALSHENEK-LKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADL 157
+ E E+ L E G+LK + + SSE D EQ+ L+ ++ RL+ + +
Sbjct: 421 SKLLETERQLGEAHGRLKEQRQLSSEKLMDK--------EQQVADLQLKLSRLEEQLKEK 472
Query: 158 LGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSR 217
+ +ELQ +L+ + +H ST L +
Sbjct: 473 VTNSTELQHQLDKTKQ----------------------QHQEQQALQQSTTAKLRE---- 506
Query: 218 SADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEKKTSNRSEIETQ 277
A+N E Q+L + + +QK++ LE L+++KE +S EK+ +
Sbjct: 507 ----AQNDLE-------QVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQA 555
Query: 278 TEGSTEKENDEEKGPETVGSEV----EALNLQVTSLFKELQEAHTKLSEAELMKKRLQEK 333
EG T N ++ T+ +V E L Q S + + H ++ E + + Q++
Sbjct: 556 GEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDR 615
Query: 334 CQALERKNSAIPSELNEKQELV-YTNKKLELQVESMLSEIKMEQAKTEDEKSKLTVLQMT 392
+LE + + S+LNE +E V + +++ + E +LS + A+ D ++ L Q
Sbjct: 616 VLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNA 675
Query: 393 HNKLLQEHNNALKTIEELTRKESEKVD-----RAVLKELSEK-LELAEKAL----ASKQL 442
QE N ++++T K +K + + LKE EK L L +K K+L
Sbjct: 676 LQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKL 735
Query: 443 QMDEMKQTIAKQE--EDLETMTILRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAVLL 500
+ D ++ +K++ +DL+ L +E+ ++ +++ EKE ++ L
Sbjct: 736 EADSLEVKASKEQALQDLQQQRQLNTDLELRATEL------SKQLEMEKEIVSSTRLDLQ 789
Query: 501 KENDAFE 507
K+++A E
Sbjct: 790 KKSEALE 796
Score = 75.5 bits (184), Expect = 1e-13
Identities = 115/503 (22%), Positives = 211/503 (41%), Gaps = 48/503 (9%)
Query: 38 EELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERL 97
+ L QQ++E TEN +K+ L Q E++ K EER E ++
Sbjct: 138 QSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLT 197
Query: 98 MALSHEN---EKLKEELGKLKG-------KSERSSEDPTDDSRLPRAEAEQEKDQLRTQV 147
L+ E + LK EL + G K E D+ E E+E ++L+ +
Sbjct: 198 EELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNM--TLERERESEKLKDEC 255
Query: 148 VRLQAEKADLLGIVSELQLKLNSSGSSEDSFVE--IRMAEGEAEGSVKEIKHSPGPTRTV 205
+LQ++ A +S+L+ +L +V+ ++ E + K + +
Sbjct: 256 KKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKE 315
Query: 206 STGTALSKYRSRSADGAKNY---FEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVS 262
T L + + + KN ++L QL L + R+ V L E E
Sbjct: 316 QDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEAT- 374
Query: 263 DFEKKTSNRSEIETQTEG--------STEKENDEEKGPETVGSEVEALNLQVTSLFKELQ 314
+K SE+ET+ + ++E E+ G + + SE+ L+ ++ ++L
Sbjct: 375 --QKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQ-LQSEINQLHSKLLETERQLG 431
Query: 315 EAHTKLSE-AELMKKRLQEKCQA---LERKNSAIPSELNEKQELVYTNKKLELQVESMLS 370
EAH +L E +L ++L +K Q L+ K S + +L EK V + +L+ Q++
Sbjct: 432 EAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEK---VTNSTELQHQLDKTKQ 488
Query: 371 EIKMEQAKTEDEKSKLTVLQMTHNKLLQ---EHNNALKTIEELTRKESEKVD--RAVLKE 425
+ + +QA + +KL Q ++L+ + + ++ +E L +K E + ++
Sbjct: 489 QHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKERED 548
Query: 426 LSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERAAREKI 485
L K++ E A Q+ E T+ QE+ + L+ Q E S A+ +++
Sbjct: 549 LYAKIQAGEGETAVLN-QLQEKNHTL--QEQVTQLTEKLKNQSE---SHKQAQENLHDQV 602
Query: 486 HEEKEQL-ALQLAVLLKENDAFE 507
E+K L A Q VL E E
Sbjct: 603 QEQKAHLRAAQDRVLSLETSVNE 625
Score = 72.0 bits (175), Expect = 1e-12
Identities = 120/511 (23%), Positives = 232/511 (45%), Gaps = 53/511 (10%)
Query: 26 HLAHPNLDTFTPEELLQQMKELLTENHQL--KEAMKLNNQAMKGRFEELSAWTEKQKEER 83
H L T +L + +L Q+ K+ N +A+ + +E + EK++E+
Sbjct: 490 HQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDL 549
Query: 84 QFFEIQSKEAKERLM-ALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQ 142
+ +IQ+ E + ++ L +N L+E++ +L K + SE + E DQ
Sbjct: 550 -YAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESH-------KQAQENLHDQ 601
Query: 143 LRTQVVRLQAEKADLLGI---VSELQLKLNSSGSSEDSFVEIRM-AEGEAEGSVKEIKHS 198
++ Q L+A + +L + V+EL +LN S + S ++I++ A+ E S + K +
Sbjct: 602 VQEQKAHLRAAQDRVLSLETSVNELNSQLNES-KEKVSQLDIQIKAKTELLLSAEAAKTA 660
Query: 199 PGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAK 258
TA + + + + K + +++T L++ + +LE LKE K
Sbjct: 661 QRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAK-----LQDKQEHCSQLESHLKEYK 715
Query: 259 ERVSDFEKKTSN-RSEIETQTEGSTEKENDEEKGPETVGSEVEA---LNLQVTSLFKELQ 314
E+ E+KT +I+ S E + +E+ + + + + L L+ T L K+L+
Sbjct: 716 EKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLE 775
Query: 315 EAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYT----NKKLELQVESMLS 370
+S L LQ+K +ALE + + EKQ L +++ ++Q E + +
Sbjct: 776 MEKEIVSSTRL---DLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNN 832
Query: 371 EIKM---EQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELS 427
I+ E K + EK L T L + +++LK + KE++K A+L
Sbjct: 833 RIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILD--- 889
Query: 428 EKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERAAREKIHE 487
LE K L QLQ+ +M+ T+ +Q+E L+ +E + A + +++
Sbjct: 890 --LEKTCKEL-KHQLQV-QMENTLKEQKE-------LKKSLE---KEKEASHQLKLELNS 935
Query: 488 EKEQLALQLAVLLKENDAFEDGGRQSLMEMQ 518
+EQL +Q LK+N+ E + ++ E++
Sbjct: 936 MQEQL-IQAQNTLKQNEKEEQQLQGNINELK 965
Score = 72.0 bits (175), Expect = 1e-12
Identities = 132/573 (23%), Positives = 243/573 (42%), Gaps = 73/573 (12%)
Query: 32 LDTFTPEELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQ------F 85
LD E L+ +K+ LT+ + K+ +K + FE LS T+ Q EE
Sbjct: 786 LDLQKKSEALESIKQKLTKQEEEKQILKQD-------FETLSQETKIQHEELNNRIQTTV 838
Query: 86 FEIQS-KEAKERLMA-LSHENEKLKEELGKLKG-KSERSSEDPTDDSRLPRAE--AEQEK 140
E+Q K KE LM LS +KL + LK KSE E+ + + E ++ K
Sbjct: 839 TELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELK 898
Query: 141 DQLRTQVVRLQAEKADLLGIVS-------ELQLKLNSSGS----SEDSFVEIRMAEGEAE 189
QL+ Q+ E+ +L + +L+L+LNS ++++ + E + +
Sbjct: 899 HQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQ 958
Query: 190 GSVKEIKHSPGPTRT-VSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVE 248
G++ E+K S + + K +N + + +Q L +E ++
Sbjct: 959 GNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQ 1018
Query: 249 R-LEVALKEAKERVSDFEKKTSN----RSEIETQTEGSTEKENDEEKGPETVGSEVEALN 303
E + + K+ SDF + S R ++++ E + + D +G++
Sbjct: 1019 NNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQ----- 1073
Query: 304 LQVTSLFKELQEAHTKLSEAELMKKR-LQEKCQALERKNSAIPSELNEKQELVYTNKKLE 362
L +EL+ A L + K++ LQE+C+AL+ I E + K++ + K
Sbjct: 1074 ---NKLIQELKTAKATLEQDSAKKEQQLQERCKALQD----IQKEKSLKEKELVNEK--- 1123
Query: 363 LQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTR-KESEKVDRA 421
S L+EI+ + + E E +KL N+ L+ H L++I+E+T K+++++
Sbjct: 1124 ----SKLAEIEEIKCRQEKEITKL-------NEELKSHK--LESIKEITNLKDAKQLLIQ 1170
Query: 422 VLKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERAA 481
EL K + + A+ ++ +K + K+EE+L+ I + E E+
Sbjct: 1171 QKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFI---EKEAKLHSEIKEKEV 1227
Query: 482 REKIHEEKEQLALQLAVLLKENDAFEDGGRQSLMEMQSRHGARTSDSDQQAYLVQRGAED 541
K HEE E L EN QS S +T D + +++ ++
Sbjct: 1228 GMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQN 1287
Query: 542 RDWRQQRNIPIHSCPKCGEVLPDIDTLQIHVMD 574
+ +R + C K GE +I+ LQ V++
Sbjct: 1288 N--QDERRALLERCLK-GE--GEIEKLQTKVLE 1315
Score = 69.7 bits (169), Expect = 7e-12
Identities = 110/472 (23%), Positives = 199/472 (42%), Gaps = 79/472 (16%)
Query: 68 RFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKS---ERSSED 124
+ ++++A + ++E E KE KE+ ++L + E+L+ ++ KL+ S + S E
Sbjct: 689 QLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQ 748
Query: 125 PTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMA 184
D + R Q L + L + IVS +L L + +S +
Sbjct: 749 ALQDLQQQR----QLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTK 804
Query: 185 EGEAEGSVKE----------IKHSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVS 234
+ E + +K+ I+H R +T T L K + K E TV
Sbjct: 805 QEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKME-----KEALMTELSTVK 859
Query: 235 QLLLCLREG--NQKVERLEVALKEAKERVSDFEKKTSN-RSEIETQTEGSTEKENDEEKG 291
L + + N K E E ++ K + D EK + +++ Q E + +++ + +K
Sbjct: 860 DKLSKVSDSLKNSKSE-FEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKS 918
Query: 292 PETVGSEVEALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEK 351
E L L++ S+ ++L +A L + E +++LQ +NE
Sbjct: 919 LEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQ--------------GNINEL 964
Query: 352 QELVYTNKKLELQVESMLSEI------------KMEQAKTE------DEKSKLTVLQMTH 393
++ KK Q+E++ E+ K++Q T+ EK K++VLQ +
Sbjct: 965 KQSSEQKKK---QIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNY 1021
Query: 394 NKLLQEHNNALKTIEELTRKESEKV-DRAVLKELSEKLELAEKALASKQLQ-------MD 445
K QE L++ + +ESE + R LK + EKL LA++ L S + Q +
Sbjct: 1022 EK-SQETFKQLQS--DFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQ 1078
Query: 446 EMKQTIAKQEEDLETMTILRAQMEVYC---SDFHAERAAREK-IHEEKEQLA 493
E+K A E+D Q++ C D E++ +EK + EK +LA
Sbjct: 1079 ELKTAKATLEQDSAKK---EQQLQERCKALQDIQKEKSLKEKELVNEKSKLA 1127
Score = 51.2 bits (121), Expect = 3e-06
Identities = 75/390 (19%), Positives = 159/390 (40%), Gaps = 43/390 (11%)
Query: 27 LAHPNLDTFTPEELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFF 86
L L+ ++L Q +EL E ++ ++ N + + F++L + ++ E
Sbjct: 987 LQKTELENKLQQQLTQAAQELAAEKEKIS-VLQNNYEKSQETFKQLQSDFYGRESELLAT 1045
Query: 87 EIQSKEAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQ 146
K +E+L S E L ++ +++ E T + L + A++E+
Sbjct: 1046 RQDLKSVEEKL---SLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQ------ 1096
Query: 147 VVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVS 206
+LQ L I E LK + + EI + E + ++
Sbjct: 1097 --QLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEE-------- 1146
Query: 207 TGTALSKYRSRSADGAKNYFEHEELTVSQLL------------LCLREGNQKVERLEVAL 254
L ++ S N + ++L + Q L + + NQ++ + +V
Sbjct: 1147 ----LKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKK 1202
Query: 255 KEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQ 314
+E + + EK+ SEI+ + G + E +E K + ++ ALN + ++ KE Q
Sbjct: 1203 EEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAK----LTMQITALNENLGTVKKEWQ 1258
Query: 315 EAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKM 374
+ ++SE E L+ + LE + + + +E++ L+ K E ++E + +++
Sbjct: 1259 SSQRRVSELEKQTDDLRGEIAVLE---ATVQNNQDERRALLERCLKGEGEIEKLQTKVLE 1315
Query: 375 EQAKTEDEKSKLTVLQMTHNKLLQEHNNAL 404
Q K ++ + + L + L +H AL
Sbjct: 1316 LQRKLDNTTAAVQELGRENQSLQIKHTQAL 1345
Score = 37.0 bits (84), Expect = 0.049
Identities = 55/267 (20%), Positives = 114/267 (42%), Gaps = 46/267 (17%)
Query: 245 QKVERLEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNL 304
Q+V+ L+ +LKE K + +K+ ++ Q E P+ +
Sbjct: 90 QEVQDLQASLKEEKWYSEELKKELEKYQGLQQQ-----------EAKPDGL--------- 129
Query: 305 QVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQ 364
VT ELQ +L EA+ +++ E+K + + +E+ + + + L
Sbjct: 130 -VTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREA 188
Query: 365 VESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLK 424
E ++ + TE+ + TV+Q +LLQ IE++ + E V ++
Sbjct: 189 AEQKVTRL------TEELNKEATVIQDLKTELLQRPG-----IEDVAVLKKELVQ---VQ 234
Query: 425 ELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQM-------EVYCSDFHA 477
L + + L E+ S++L+ DE K+ ++ T++ LR+++ VY +
Sbjct: 235 TLMDNMTL-ERERESEKLK-DECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQK 292
Query: 478 ERAAREKIHEEKEQLALQLAVLLKEND 504
+++ ++ ++ + L L L KE D
Sbjct: 293 LKSSVNELTQKNQTLTENL--LKKEQD 317
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 78.6 bits (192), Expect = 1e-14
Identities = 128/574 (22%), Positives = 240/574 (41%), Gaps = 117/574 (20%)
Query: 32 LDTFTPEELLQQMKE--LLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEE------- 82
L+ T E +++M+E LL E+ K + + M+ R E S+ +++E+
Sbjct: 971 LEKVTAEAKIKKMEEEILLLEDQNSKFIKE--KKLMEDRIAECSSQLAEEEEKAKNLAKI 1028
Query: 83 RQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQ 142
R E+ + +ERL + EK ++EL K K K + + D D +A+ ++ K Q
Sbjct: 1029 RNKQEVMISDLEERLK----KEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQ 1084
Query: 143 LRTQVVRLQA----------EKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSV 192
L + LQ K + L +V ELQ ++ ++ F + + +AE
Sbjct: 1085 LAKKEEELQGALARGDDETLHKNNALKVVRELQAQI---AELQEDFESEKASRNKAEKQK 1141
Query: 193 KEIKHSPGPTRT-----VSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKV 247
+++ +T + T A + R++ E V++L L E +
Sbjct: 1142 RDLSEELEALKTELEDTLDTTAAQQELRTK-----------REQEVAELKKALEEETKNH 1190
Query: 248 E--------RLEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEV 299
E R AL+E E++ ++ +N + + E ++ E K + V +E
Sbjct: 1191 EAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAES 1250
Query: 300 EALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALE--------------------- 338
E ++ + ++QE H K+SE + ++ L EK L+
Sbjct: 1251 EHKRKKLDA---QVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFA 1307
Query: 339 RKNSAIPSELNEKQELVYTNKKLELQVESMLSEIK------MEQAKTEDEKSK-----LT 387
+ +++ S+L + QEL+ + +L + S + +++ EQ + E+E K +
Sbjct: 1308 KDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVL 1367
Query: 388 VLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKE---LSEKLELAEKALASKQLQ- 443
LQ ++ ++ L TIE L E+ + +LK+ LS++LE EKALA +L+
Sbjct: 1368 ALQSQLADTKKKVDDDLGTIESL-----EEAKKKLLKDAEALSQRLE--EKALAYDKLEK 1420
Query: 444 ---------------MDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERAAREKIHEE 488
+D +Q + E+ + L A+ + + + ER E E
Sbjct: 1421 TKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEARE 1480
Query: 489 KEQLALQLAVLLKE----NDAFEDGGRQSLMEMQ 518
KE AL LA L+E + FE +Q +M+
Sbjct: 1481 KETKALSLARALEEALEAKEEFERQNKQLRADME 1514
Score = 70.9 bits (172), Expect = 3e-12
Identities = 107/569 (18%), Positives = 225/569 (39%), Gaps = 30/569 (5%)
Query: 9 LTEKEDSPSESTGNGPPHLAHPNLDTFTPEELLQQMKEL--------LTENHQLKEAMKL 60
L +KE+ + G H N EL Q+ EL + N K+ L
Sbjct: 1085 LAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDL 1144
Query: 61 NN--QAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKS 118
+ +A+K E+ T Q+E R E + E K+ L + +E +++ + +
Sbjct: 1145 SEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATA 1204
Query: 119 ERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSF 178
+ + ++ +A E+ K L T L E L + +E + K +
Sbjct: 1205 LEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQE- 1263
Query: 179 VEIRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLL 238
+ +++EG+ K S + T L + + AK+ E L
Sbjct: 1264 LHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQEL 1323
Query: 239 CLREGNQKV---ERLEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETV 295
E QK+ R+ +E E++ R +E Q + D +K +
Sbjct: 1324 LQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDD 1383
Query: 296 GSEVEALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELV 355
+E+L L K+ + +L E L +L++ L+++ + +L+ ++++
Sbjct: 1384 LGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVA 1443
Query: 356 YTNKKLELQVESMLSEIKMEQAKTEDEKSKLTV----LQMTHNKLLQEHNNALKTIEELT 411
+K + + + +L+E K A+ +E+ + + L + AL+ EE
Sbjct: 1444 SNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFE 1503
Query: 412 RKESE-KVDRAVL----KELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRA 466
R+ + + D L ++ + + EK+ + + Q++EM+ + + E++L+ +
Sbjct: 1504 RQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKL 1563
Query: 467 QMEVYC----SDFHAERAAREKIHEEKEQLALQLAVLLKENDAFEDGGRQSLMEMQSRHG 522
++EV + F + R++ +EEK++L ++ L+ ED +Q + + S+
Sbjct: 1564 RLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAE--LEDERKQRALAVASKKK 1621
Query: 523 ARTSDSDQQAYL-VQRGAEDRDWRQQRNI 550
D +A + A D +Q R +
Sbjct: 1622 MEIDLKDLEAQIEAANKARDEVIKQLRKL 1650
Score = 70.1 bits (170), Expect = 5e-12
Identities = 70/288 (24%), Positives = 127/288 (44%), Gaps = 44/288 (15%)
Query: 240 LREGNQKVERLEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEV 299
L E N E+L+ + E + + + E+E + +EE+ + + +E
Sbjct: 886 LEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEK 945
Query: 300 EALNLQVTSLFKELQE---AHTKLS----EAELMKKRLQEKCQALERKNSAIPSELNEKQ 352
+ + + L ++L E A KL AE K+++E+ LE +NS E
Sbjct: 946 KKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKE----- 1000
Query: 353 ELVYTNKKLELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTR 412
KKL +E ++E + A+ E++ L ++ ++ + LK EE TR
Sbjct: 1001 ------KKL---MEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKK-EEKTR 1050
Query: 413 KESEKVDRAVLKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLE------------- 459
+E EK R + E ++ + +A Q Q+DE+K +AK+EE+L+
Sbjct: 1051 QELEKAKRKLDGETTD----LQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHK 1106
Query: 460 -----TMTILRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAVLLKE 502
+ L+AQ+ DF +E+A+R K ++K L+ +L L E
Sbjct: 1107 NNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTE 1154
Score = 69.3 bits (168), Expect = 9e-12
Identities = 99/501 (19%), Positives = 210/501 (41%), Gaps = 67/501 (13%)
Query: 33 DTFTPEELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKE 92
D + E LQ +ELL E + ++ + L+++ ++ EE ++ E+Q+EE + + K+
Sbjct: 1309 DAASLESQLQDTQELLQE--ETRQKLNLSSR-IRQLEEEKNSLQEQQEEEEEARKNLEKQ 1365
Query: 93 AKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEK--DQLRTQVVRL 150
L+ +K+ ++LG ++ E + D L + E+ D+L RL
Sbjct: 1366 VLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRL 1425
Query: 151 QAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSTGTA 210
Q E DL + + ++ + F ++
Sbjct: 1426 QQELDDLTVDLDHQRQVASNLEKKQKKFDQL----------------------------- 1456
Query: 211 LSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEKKTSN 270
L++ +S SA Y E + ++ RE K L AL+EA E +FE++
Sbjct: 1457 LAEEKSISA----RYAEERDRAEAEA----REKETKALSLARALEEALEAKEEFERQNK- 1507
Query: 271 RSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAELMKKRL 330
++ E ++D K + AL QV + +L+E +L E K RL
Sbjct: 1508 --QLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRL 1565
Query: 331 QEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQAKTEDEKSKLTVLQ 390
+ QA++ + +L + E K+L ++ +++ +A+ EDE+ + +
Sbjct: 1566 EVNMQAMK---AQFERDLQTRDEQNEEKKRL------LIKQVRELEAELEDERKQRALAV 1616
Query: 391 MTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKLELAEKALASKQLQMDEMKQT 450
+ K+ + + IE + E + + L++L +++ ++ L + DE+
Sbjct: 1617 ASKKKMEIDLKDLEAQIEAANKARDEVIKQ--LRKLQAQMKDYQRELEEARASRDEI--- 1671
Query: 451 IAKQEEDLETMTILRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAVLLKENDAFEDGG 510
A+ +E + + L A++ + + AR +E+++LA ++ N A G
Sbjct: 1672 FAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEIT-----NSA---SG 1723
Query: 511 RQSLMEMQSRHGARTSDSDQQ 531
+ +L++ + R AR + +++
Sbjct: 1724 KSALLDEKRRLEARIAQLEEE 1744
Score = 61.6 bits (148), Expect = 2e-09
Identities = 103/510 (20%), Positives = 209/510 (40%), Gaps = 60/510 (11%)
Query: 27 LAHPNLDTFTPEELLQQMKELLTE-NHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQF 85
LA+ L+ T L Q++ +L + +HQ + A L + K F++L A EE+
Sbjct: 1413 LAYDKLEK-TKNRLQQELDDLTVDLDHQRQVASNLEKKQKK--FDQLLA------EEKS- 1462
Query: 86 FEIQSKEAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRT 145
I ++ A+ER A + EK + L + E + E E++ QLR
Sbjct: 1463 --ISARYAEERDRAEAEAREKETKALSLARALEEALEA---------KEEFERQNKQLRA 1511
Query: 146 QVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTV 205
+ L + K D+ V EL+ S + E E+R E E ++ + +
Sbjct: 1512 DMEDLMSSKDDVGKNVHELE---KSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEV- 1567
Query: 206 STGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFE 265
++ A ++ +E + L +++ + LE K+ V+ +
Sbjct: 1568 -------NMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKK 1620
Query: 266 KKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAEL 325
K + ++E Q E + K + V ++ L Q+ +EL+EA E
Sbjct: 1621 KMEIDLKDLEAQIEAAN-------KARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFA 1673
Query: 326 MKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQAKTE---DE 382
K ++K ++LE + + EL + + E + + + EI + DE
Sbjct: 1674 QSKESEKKLKSLEAEILQLQEELASSER---ARRHAEQERDELADEITNSASGKSALLDE 1730
Query: 383 KSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKLELAEKALASKQL 442
K +L + L+E + ++ + + RK + +VD + EL+ + A+K+ ++Q
Sbjct: 1731 KRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVD-TLNAELAAERSAAQKSDNARQ- 1788
Query: 443 QMDEMKQTIAKQEEDLE---------TMTILRA---QMEVYCSDFHAERAAREKIHEEKE 490
Q++ + + + ++LE T++ L A Q+E ERAA K+ E
Sbjct: 1789 QLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTE 1848
Query: 491 QLALQLAVLLKENDAFEDGGRQSLMEMQSR 520
+ ++ + +++ D ++ + + +R
Sbjct: 1849 KKLKEIFMQVEDERRHADQYKEQMEKANAR 1878
Score = 58.9 bits (141), Expect = 1e-08
Identities = 66/306 (21%), Positives = 132/306 (43%), Gaps = 37/306 (12%)
Query: 54 LKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGK 113
+K+ KL Q MK EL E+ + R QSKE++++L +L E +L+EEL
Sbjct: 1644 IKQLRKLQAQ-MKDYQREL----EEARASRDEIFAQSKESEKKLKSLEAEILQLQEELAS 1698
Query: 114 LKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGS 173
SER+ R AEQE+D+L ++ + K+ LL L+ ++
Sbjct: 1699 ----SERA-----------RRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEE 1743
Query: 174 SEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTV 233
E+ + E + + T++ A + ++ +D A+ E + +
Sbjct: 1744 ------ELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKEL 1797
Query: 234 SQLLLCLREGNQK------VERLEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEK--- 284
L L EG K + LE + + +E++ K+ + +++ +TE ++
Sbjct: 1798 KAKLQEL-EGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFM 1856
Query: 285 -ENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSA 343
DE + + ++E N ++ L ++L+EA + + A +++LQ + N
Sbjct: 1857 QVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEG 1916
Query: 344 IPSELN 349
+ E++
Sbjct: 1917 LSREVS 1922
Score = 55.5 bits (132), Expect = 1e-07
Identities = 54/219 (24%), Positives = 101/219 (46%), Gaps = 29/219 (13%)
Query: 304 LQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLEL 363
LQVT +ELQ +L + + + +++ + + +ERK+ + E N E + +L
Sbjct: 845 LQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFA 904
Query: 364 QVESMLSEIKME-----------QAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTR 412
+ E M + + + +++ E+E+ + +LQ K +Q H L+ E+L
Sbjct: 905 EAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQ-NEKKKMQAHIQDLE--EQLDE 961
Query: 413 KES-------EKVD-RAVLKELSEKLELAE----KALASKQLQMD---EMKQTIAKQEED 457
+E EKV A +K++ E++ L E K + K+L D E +A++EE
Sbjct: 962 EEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEK 1021
Query: 458 LETMTILRAQMEVYCSDFHAERAAREKIHEEKEQLALQL 496
+ + +R + EV SD EK +E E+ +L
Sbjct: 1022 AKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKL 1060
>gi|14165274 golgi-associated microtubule-binding protein HOOK3
[Homo sapiens]
Length = 718
Score = 78.2 bits (191), Expect = 2e-14
Identities = 86/406 (21%), Positives = 170/406 (41%), Gaps = 41/406 (10%)
Query: 120 RSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFV 179
+ + + +++ + E Q +L QV LQ EK+ LL L +LN S S ED
Sbjct: 179 KKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDPNS 238
Query: 180 EIRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSRSADGAKNYFE----HEELT--- 232
+ + +++++ T A YR R + K E ++ELT
Sbjct: 239 PAGRRHLQLQTQLEQLQEE-----TFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLA 293
Query: 233 -----VSQLLLCLREGNQKVERLEVALKEAKERVSDF---EKKTSNRSEIETQTEGSTEK 284
+ + LR + KV +LE ++ K+++ D ++ E T +T
Sbjct: 294 DEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVS 353
Query: 285 ENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAI 344
+E + S++E QV L L E K + + KRL+EK +L+++ +
Sbjct: 354 LEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRL 413
Query: 345 PSELNEKQELVYTNKKLELQVESMLSE--IKMEQAKTEDEKSKLTVLQMTHNKL--LQEH 400
+E + +E + + ++ Q + ++ + + ++ D + V KL LQ
Sbjct: 414 RTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHE 473
Query: 401 NNALKTIEELTRKESEKVDRAVL-------KELSEKLELAEKALASKQLQMDEMKQTIAK 453
N LK +E + E + +++L EL + L + L Q Q++E+++++
Sbjct: 474 NKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQD 533
Query: 454 QEEDLETMTILRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAVL 499
Q E +L+ ++E + EK+HE +L + A++
Sbjct: 534 QGSKAEDSVLLKKKLEEHL----------EKLHEANNELQKKRAII 569
Score = 55.1 bits (131), Expect = 2e-07
Identities = 80/397 (20%), Positives = 174/397 (43%), Gaps = 34/397 (8%)
Query: 38 EELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERL 97
EEL +++ EL +N +L + Q++K + L ++K + E Q + K++L
Sbjct: 273 EELEKEISELRQQNDELT-TLADEAQSLKDEIDVLRHSSDKVSK----LEGQVESYKKKL 327
Query: 98 MALS--HENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAE-- 153
L KL EE + ++ S E+ + R++ E K Q+ RL E
Sbjct: 328 EDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESK 387
Query: 154 KADLLGI-VSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSTGTALS 212
KAD L L+ K++S +D +R + +++E++ ++T +
Sbjct: 388 KADKLDFEYKRLKEKVDSLQKEKD---RLRTERDSLKETIEELRCVQAQEGQLTTQGLMP 444
Query: 213 KYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEKKTSNRS 272
S+D E + + L+ L+ N+ ++ + SD EK
Sbjct: 445 LGSQESSDSLAAEIVTPE--IREKLIRLQHENKMLK--------LNQEGSDNEKIAL--- 491
Query: 273 EIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAELMKKRLQE 332
+++ + + ++N+ E V + + QV L K LQ+ +K ++ L+KK+L+E
Sbjct: 492 -LQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEE 550
Query: 333 KCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQAKTEDEKSKLTVLQMT 392
+ L N +EL +K+ ++ + LE + + +I+ Q ++ ++ ++
Sbjct: 551 HLEKLHEAN----NELQKKRAII---EDLEPRFNNSSLKIEELQEALRKKEEEMKQMEER 603
Query: 393 HNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEK 429
+ K L++ + ++T++ + + +A+ +L E+
Sbjct: 604 YKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQER 640
Score = 53.5 bits (127), Expect = 5e-07
Identities = 65/301 (21%), Positives = 130/301 (43%), Gaps = 34/301 (11%)
Query: 235 QLLLCLREGNQKVERLEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPET 294
Q ++ + E Q V + A++E + S +++ Q + +TE+ N+ E
Sbjct: 137 QAIMMMEESVQHV--VMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSAKEE 194
Query: 295 VGSEVEALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNS-------AIPSE 347
+ L++QV +L +E + L+E +++ +RL + ++E NS + ++
Sbjct: 195 IAQRCHELDMQVAAL---QEEKSSLLAENQVLMERLNQS-DSIEDPNSPAGRRHLQLQTQ 250
Query: 348 LNEKQELVYTNKKLELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTI 407
L + QE + + + E++ E ++ + +LT L + +LK
Sbjct: 251 LEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTT--------LADEAQSLKDE 302
Query: 408 EELTRKESEKVDRAVLKELSEKLELAEKALASKQLQMDEMKQTIAKQ-----EEDLETMT 462
++ R S+KV + + S K +L + +Q+++ E K T+ Q EE+L
Sbjct: 303 IDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKAN 362
Query: 463 ILRAQMEVY-------CSDFHAERAAREKIHEEKEQLALQLAVLLKENDAFEDGGRQSLM 515
R+Q+E Y + E +K+ E ++L ++ L KE D R SL
Sbjct: 363 AARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRT-ERDSLK 421
Query: 516 E 516
E
Sbjct: 422 E 422
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 77.8 bits (190), Expect = 3e-14
Identities = 106/492 (21%), Positives = 209/492 (42%), Gaps = 50/492 (10%)
Query: 38 EELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERL 97
EEL Q E + EN L++ ++ + ++ EEL + K ER+ + + ++ +++L
Sbjct: 652 EELRSQHNEKVEENSTLQQRLEESEGELRKNLEELF----QVKMEREQHQTEIRDLQDQL 707
Query: 98 MALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADL 157
+ E + K + KG D + E+++D LR + L A K L
Sbjct: 708 SEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGAL 767
Query: 158 LGIVSELQLKLNSSGSSEDSFVE-IRMAEGEAEGSVKEIKHSPGPTRTVSTGTALS-KYR 215
VS +++ D+ ++ +R + EA +V+ + + GT + K
Sbjct: 768 KEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLL 827
Query: 216 SRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEKKTSNRSEIE 275
+ + E E V+QL +++E L+ +AKE + +E + ++E
Sbjct: 828 QEENEKLQGRSEELERRVAQL-------QRQIEDLKGDEAKAKETLKKYEGEI---RQLE 877
Query: 276 TQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQ 335
+ ++E + + +E+EA ++ +E ++ KL E K++L+
Sbjct: 878 EALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKN 937
Query: 336 ALERK----NSAIPSELNEKQELVYTNKKLELQVESMLSEIK-------------MEQAK 378
+E + I E ++V ++ L++++ L E K +++
Sbjct: 938 EMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKT 997
Query: 379 TEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKE--LSEKLELAEKA 436
E EKS+LT ++M + ++ +EE R D A+ K L + L+ E
Sbjct: 998 LEAEKSRLTAMKM---------QDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYE 1048
Query: 437 LASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERAAREKIHEEKEQLALQL 496
L +K D+ + + KQ ED + + + E SD +ER +R + E+ EQL +
Sbjct: 1049 LEAKSHLKDD-RSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSR--EQMEQLRNE- 1104
Query: 497 AVLLKENDAFED 508
LL+E A +D
Sbjct: 1105 --LLQERAARQD 1114
Score = 68.6 bits (166), Expect = 2e-11
Identities = 103/483 (21%), Positives = 199/483 (41%), Gaps = 63/483 (13%)
Query: 50 ENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKE 109
E +LKE QA++ EE + E E + R+ L ENE
Sbjct: 777 EMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENE---- 832
Query: 110 ELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADLL-------GIVS 162
KL+G+SE E E+ QL+ Q+ L+ ++A G +
Sbjct: 833 ---KLQGRSE---------------ELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIR 874
Query: 163 ELQLKLNSSGSSEDSFVEIRMA-EGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSRSADG 221
+L+ L + E V R A E E E + + + + +S +
Sbjct: 875 QLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRR 934
Query: 222 AKNYFEHEELTVSQLLLCL-REGNQKVERLEVALKEAKERVSDFEKKTSNRSEIETQTEG 280
KN E+E + + + L +E VE + E + ++ ++++K NR E+
Sbjct: 935 LKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEK--NRRELAEMQRQ 992
Query: 281 STEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERK 340
EK + EK S + A+ +Q E + + ++ E + KR Q LE+
Sbjct: 993 LKEKTLEAEK------SRLTAMKMQDEMRLMEEELRDYQRAQDEALTKR-----QLLEQT 1041
Query: 341 NSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEH 400
+ EL K L +L Q+E +S+++ME + + L+ + +++
Sbjct: 1042 LKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQL 1101
Query: 401 NNALKTIEELTRKESEKVDRAVLKELSEKLE-----LAEKALASKQLQMDEMKQTIAKQE 455
N L ++E ++ + D+ L+ ++ L+ L +SK+ + +M+ IA+ E
Sbjct: 1102 RNEL--LQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELE 1159
Query: 456 EDLETMTILRAQMEVYCSDFHAERAARE----------KIHEEKEQLALQLAVLLKENDA 505
+ LE+ RA +++ S+ ER +E + ++K+QL+L+L + ++ +
Sbjct: 1160 DRLESEERDRANLQL--SNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEE 1217
Query: 506 FED 508
E+
Sbjct: 1218 AEE 1220
Score = 66.6 bits (161), Expect = 6e-11
Identities = 85/415 (20%), Positives = 181/415 (43%), Gaps = 34/415 (8%)
Query: 41 LQQMKELLTENHQLKEAMKLNNQAMKGRFE----ELSAWTEKQKEERQFFEIQSKEAKER 96
++Q++E L + ++ +A++ E LS T++QK+ + + +S E KE+
Sbjct: 873 IRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEES-EQKEQ 931
Query: 97 LMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKAD 156
L L +E E + LGK K ++ D + SR E + + D+ + + R AE
Sbjct: 932 LRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEM-- 989
Query: 157 LLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRS 216
+ QLK + + + ++M + E +E++ T L +
Sbjct: 990 ------QRQLKEKTLEAEKSRLTAMKMQD-EMRLMEEELRDYQRAQDEALTKRQLLEQTL 1042
Query: 217 RSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEKKTSNRSEIET 276
+ + H + S+L+ ++ KV +LE+ L+E + ++ S E
Sbjct: 1043 KDLEYELEAKSHLKDDRSRLV---KQMEDKVSQLEMELEEERNNSDLLSERISRSREQME 1099
Query: 277 QTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQA 336
Q +E + E +E N + S L+ ++ E +++ ++ +
Sbjct: 1100 QLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQ--MEARIAE 1157
Query: 337 LERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKL 396
LE + + SE ++ L +N++LE +V+ ++ ++ E D+K +L++ +
Sbjct: 1158 LEDR---LESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQ 1214
Query: 397 LQEHNNALKTIEELTRKESEKVDRAVLKELSEKLELAEKALASKQLQMDEMKQTI 451
++E EE+ R ES K + + +EL E++++ E Q Q++ MK+ +
Sbjct: 1215 VEEAE------EEIDRLESSK--KKLQRELEEQMDMNEHL----QGQLNSMKKDL 1257
Score = 65.9 bits (159), Expect = 1e-10
Identities = 113/551 (20%), Positives = 234/551 (42%), Gaps = 96/551 (17%)
Query: 38 EELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERL 97
++LL+Q +L E +L+ ++L + + KEER+ +E + +
Sbjct: 610 KDLLEQKSKLTIEVAELQRQLQLEVKNQ-----------QNIKEERERMRANLEELRSQH 658
Query: 98 MALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADL 157
EN L++ L + +G+ ++ E+ + + E++Q +T++ LQ +
Sbjct: 659 NEKVEENSTLQQRLEESEGELRKNLEE--------LFQVKMEREQHQTEIRDLQDQ---- 706
Query: 158 LGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSTGTA----LSK 213
+SE+ +L+S+ SED E ++E+ + + + L +
Sbjct: 707 ---LSEMHDELDSAKRSEDR---------EKGALIEELLQAKQDLQDLLIAKEEQEDLLR 754
Query: 214 YRSRSADGAKNYFEHEELTVSQLLLCLREG-NQKVERLEVALKEAKERVSDFEKKTSNRS 272
R R K + E + Q + L+E + +++ L +++EA + V +++
Sbjct: 755 KRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSE 814
Query: 273 EIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAELMKKRLQE 332
+ + TE + +E E + E L +V L +++++ ++A+ K+ +
Sbjct: 815 QDQAGTEMRVKLLQEEN---EKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEG 871
Query: 333 KCQALERKNSAIPSELNEKQELVYTNKKLELQVESM---LSEIKMEQ----AKTEDEKSK 385
+ + LE A+ E++E V + LE ++E+ LS+ EQ K ++E +
Sbjct: 872 EIRQLE---EALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQ 928
Query: 386 LTVLQMTHNKLLQEHNNALKTIEELTRKESEKVD--RAVLKELSEKL---------ELAE 434
L+ N++ E + KTIE+L ++ ++ V+ R EL +L ELAE
Sbjct: 929 KEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAE 988
Query: 435 --KALASKQLQMDEMKQTIAKQEEDLETM-----TILRAQ---------MEVYCSDFHAE 478
+ L K L+ ++ + T K ++++ M RAQ +E D E
Sbjct: 989 MQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYE 1048
Query: 479 RAAREKIHEEKEQLALQLAVLLKENDAFEDGGRQSLMEMQSRHGARTSDSDQQAYLVQRG 538
A+ + +++ +L Q+ ED Q ME++ ++SD + + R
Sbjct: 1049 LEAKSHLKDDRSRLVKQM----------EDKVSQLEMELEEER----NNSDLLSERISRS 1094
Query: 539 AEDRDWRQQRN 549
E + Q RN
Sbjct: 1095 REQME--QLRN 1103
Score = 42.0 bits (97), Expect = 0.002
Identities = 55/246 (22%), Positives = 106/246 (43%), Gaps = 27/246 (10%)
Query: 309 LFKELQEAHTKLSEAELMKKRLQ-EKCQALERK-------NSAIPSELNEKQELVYTNKK 360
L+ L+E T +A K L EK Q L+ + N+ + +E ++L+ K
Sbjct: 559 LYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSK 618
Query: 361 LELQVESMLSEIKME-------QAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRK 413
L ++V + ++++E + + E ++ L L+ HN+ ++E++ + +E
Sbjct: 619 LTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLE----- 673
Query: 414 ESEKVDRAVLKELSE---KLELAEKALASKQLQMDEMKQTI--AKQEEDLETMTILR--A 466
ESE R L+EL + + E + + Q Q+ EM + AK+ ED E ++
Sbjct: 674 ESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELL 733
Query: 467 QMEVYCSDFHAERAAREKIHEEKEQLALQLAVLLKENDAFEDGGRQSLMEMQSRHGARTS 526
Q + D + +E + ++E+ L LKE + D L E
Sbjct: 734 QAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALR 793
Query: 527 DSDQQA 532
+S ++A
Sbjct: 794 ESVEEA 799
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 77.4 bits (189), Expect = 3e-14
Identities = 112/522 (21%), Positives = 219/522 (41%), Gaps = 73/522 (13%)
Query: 38 EELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERL 97
EEL Q K +LTE+ ++ + + R EL + EK +E + QSK+ L
Sbjct: 538 EELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQEN---KNQSKDLAVHL 594
Query: 98 MALSHEN--------EKLKEELGKLKGKSER---------SSEDPTDDSRLPRAEAEQEK 140
A +++ EK K EL LK + + + T+ +L R + EQEK
Sbjct: 595 EAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKL-REKCEQEK 653
Query: 141 DQ-LRTQVVRLQAEKADL-LGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHS 198
+ L+ + + QA ++ + +L +K S E+ A + E + +K
Sbjct: 654 ETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQ 713
Query: 199 PGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAK 258
+ + + ++ + + E+++ + L++ ++ +LE+ LKE
Sbjct: 714 TDKMKQ-ELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKD---QINQLELLLKERD 769
Query: 259 ERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHT 318
+ + + + N ++EG ++ + + + S A + Q + ++L +
Sbjct: 770 KHLKEHQAHVENLEADIKRSEGELQQASAK---LDVFQSYQSATHEQTKAYEEQLAQLQQ 826
Query: 319 KLSEAELMKKRLQEKCQALERKNSAIPSELNE--------KQELVYTNKKLELQVESM-- 368
KL + E + L ++ +E + + +EL+ Q+L N ++E +V+S+
Sbjct: 827 KLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQ 886
Query: 369 LSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVD--RAVLKEL 426
+ E K+E E E++K +L N +LQ K IE LT+K S K D + +E
Sbjct: 887 VYESKLEDGNKEQEQTK-QILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEY 945
Query: 427 SEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERAAREKIH 486
K + EK + + + EM++T+ K+ D E K+
Sbjct: 946 ETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEA-----------------------KLK 982
Query: 487 EEKEQLALQLAVLLKENDAFEDGGRQSLMEMQSRHGARTSDS 528
+E E AL+L+ K+ +A ++EM + A SD+
Sbjct: 983 KELENTALELSQKEKQFNA-------KMLEMAQANSAGISDA 1017
Score = 68.2 bits (165), Expect = 2e-11
Identities = 118/573 (20%), Positives = 233/573 (40%), Gaps = 110/573 (19%)
Query: 38 EELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQF------------ 85
E L ++ E+L H+L+E + + +EL A ++QK Q
Sbjct: 687 ESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVS 746
Query: 86 --------------FEIQSKEAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRL 131
E+ KE + L E L+ ++ + +G+ +++S
Sbjct: 747 IQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSY 806
Query: 132 PRAEAEQEKD------QLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSF---VEIR 182
A EQ K QL+ +++ L+ E+ L V+E++ + + D+ V+
Sbjct: 807 QSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDL 866
Query: 183 MAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQ--LLLCL 240
M + E + S E K + Y S+ DG K + +++ V + ++L +
Sbjct: 867 MQQLEKQNSEMEQK----------VKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQM 916
Query: 241 REGNQK-VERLEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEK-ENDEEKGPETVGSE 298
REG +K +E L L ++ + + E ET+ + +K E ++K E +
Sbjct: 917 REGQKKEIEILTQKLSAKEDSIHILNE------EYETKFKNQEKKMEKVKQKAKEMQETL 970
Query: 299 VEALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPS------ELNEKQ 352
+ L Q L KEL+ +LS+ E K+ K + + NSA S E N+K+
Sbjct: 971 KKKLLDQEAKLKKELENTALELSQKE---KQFNAKMLEMAQANSAGISDAVSRLETNQKE 1027
Query: 353 ELVYTN---------------KKLELQVESM--LSEIKMEQAKTE--DEKSKLTVLQMTH 393
++ KKL Q E + + EI++++ + E + K K+ +
Sbjct: 1028 QIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEK 1087
Query: 394 NKLLQE----------HNNALKTIEELTRKESEKV-----DRAVLKELSEKLEL-AEKAL 437
++ +E + L ++E +++S V D LK EKLE+ K+L
Sbjct: 1088 EEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSL 1147
Query: 438 ASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERAAREKIHEE--------- 488
+++ + EED ++ L ++++ +F + +++ EK ++
Sbjct: 1148 KENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFK 1207
Query: 489 --KEQLALQLAVLLKENDAFEDGGRQSLMEMQS 519
E+LA+QL + K+ +A + L+ + S
Sbjct: 1208 KLSEELAIQLDICCKKTEALLEAKTNELINISS 1240
Score = 62.8 bits (151), Expect = 8e-10
Identities = 111/527 (21%), Positives = 211/527 (40%), Gaps = 70/527 (13%)
Query: 82 ERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQ--- 138
+ F SKE+ R + +E L +L S +S DP D +EAE
Sbjct: 81 KESLFRSSSKESLVRTSS--------RESLNRLDLDSSTASFDPPSDMD---SEAEDLVG 129
Query: 139 -----EKDQLRTQVVRLQAEKADLLGIVSEL------------QLKLNSSGSSEDSFVEI 181
K+QL ++ R++ + G SEL +L+ S S + S I
Sbjct: 130 NSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRI 189
Query: 182 RMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLR 241
E + + KH L + S + Y + VS L LR
Sbjct: 190 AELREELQMDQQAKKH-------------LQEEFDASLEEKDQYISVLQTQVSLLKQRLR 236
Query: 242 EGNQKVERLEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEA 301
G V+ L+ L + + + F K+ + S+ E E T + E + V +
Sbjct: 237 NGPMNVDVLK-PLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETL-QQRVKRQENL 294
Query: 302 LNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKL 361
L ++ ++ SE E ++++L E+ Q LE+ + EK +L+ +
Sbjct: 295 LKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDL---HMAEKTKLITQLRDA 351
Query: 362 ELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRA 421
+ +E + + M A+T+ + + ++ L+ + T E R++ EK +RA
Sbjct: 352 KNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERA 411
Query: 422 VLKELSEKLELAEK---ALASKQLQMDEMKQTIAKQEED------LETMTILRAQMEVYC 472
+EL + L A+K A + +MDE +TI K E+ E + + ++V
Sbjct: 412 AFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMK 471
Query: 473 SDFHAERAAREKIHE-----EKEQLALQLAVLLKENDAFEDGGRQSLMEMQSRHGARTSD 527
+ A +K+HE ++++L +L +E F++ + +L + QS + + +
Sbjct: 472 KSSEEQIAKLQKLHEKELARKEQELTKKLQTRERE---FQEQMKVALEKSQSEYLKISQE 528
Query: 528 SDQQAYLVQRGAEDRDWRQQRNIPIHSCPKCGEVLPDIDTLQIHVMD 574
+QQ L E Q++ I S K ++ + +T + +++
Sbjct: 529 KEQQESLALEELE----LQKKAILTESENKLRDLQQEAETYRTRILE 571
Score = 59.3 bits (142), Expect = 9e-09
Identities = 124/569 (21%), Positives = 234/569 (41%), Gaps = 74/569 (13%)
Query: 27 LAHPNLDTFTPEELLQQMKELLTENHQLKEA---MKLNNQAMKGRFEELSAWTEKQKEER 83
L H NL + EE L+ +++ L K A K + + + LS EK+++ +
Sbjct: 1608 LEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYK 1667
Query: 84 QFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQL 143
+ E E +L E L+E+L ++ + P + A EQE+
Sbjct: 1668 KGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVA-AYTEQEEADS 1726
Query: 144 RTQVVRLQAEKADLLGI-VSELQLKLNSSGSSEDSFVE-------------IRMAEGEAE 189
+ V + EK +L ++E + L G ++ V I++ EA+
Sbjct: 1727 QGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAK 1786
Query: 190 --------GSVKEIKHSPGPTRTVSTGTALSKYRSRSADGAK----NYFEHEELTVSQLL 237
G ++E ++ + K ++ AK N F+ + T+ +
Sbjct: 1787 QHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKE 1846
Query: 238 LCLREGNQKVERLEVALKEAKE--RVSDFEKKTSNRSEIET--QTEGSTE-----KENDE 288
L + QK++ L+ L KE RV + E+ TS +++ Q +G + +EN E
Sbjct: 1847 LTCQILEQKIKELDSCLVRQKEVHRV-EMEELTSKYEKLQALQQMDGRNKPTELLEENTE 1905
Query: 289 EKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSEL 348
EK + N++ + + KL+ AE K++L ++ L++ + E
Sbjct: 1906 EKSKSHLVQPKLLSNMEA-----QHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKE- 1959
Query: 349 NEKQELVYTNKKLELQVESMLSEIKMEQAKTE-DEKSKLTVLQMTHNKLLQEHNNALKTI 407
+QEL K+ + + E +IK EQ E S L L N L + L+
Sbjct: 1960 -HQQELEILKKEYDQEREE---KIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMT 2015
Query: 408 EELTRKESEKVDRAVLKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQ 467
+ T ++++V+ +L+ E+ K +A K D++K+T AK+ E E + +
Sbjct: 2016 IKETINKAQEVEAELLESHQEETNQLLKKIAEKD---DDLKRT-AKRYE--EILDAREEE 2069
Query: 468 MEVYCSDFHAERAAREKIHEEKEQLALQLAVLLKENDAFEDGGRQSLMEMQSRHGART-- 525
M D + +K +++K L +E + D ++ME+Q++ +T
Sbjct: 2070 MTAKVRDLQTQLEELQKKYQQK---------LEQEENPGND--NVTIMELQTQLAQKTTL 2118
Query: 526 -SDS--DQQAYLVQ-RGAEDRDWRQQRNI 550
SDS +Q + Q EDR + ++N+
Sbjct: 2119 ISDSKLKEQEFREQIHNLEDRLKKYEKNV 2147
Score = 57.4 bits (137), Expect = 4e-08
Identities = 97/475 (20%), Positives = 203/475 (42%), Gaps = 62/475 (13%)
Query: 54 LKEAMKLNNQAMKGRFEELSAWTEKQ---KEERQFFEIQSKEAKER---LMALSHENEKL 107
L++ +N+ + + + S +T+ Q KE + E++SKEA E+ + L E ++
Sbjct: 1432 LEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQ 1491
Query: 108 KEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQ------AEKADLLGIV 161
+ LKG+ E D S++ + E+ E + L++Q R+ +K + +
Sbjct: 1492 NKRFDCLKGEME------DDKSKMEKKESNLETE-LKSQTARIMELEDHITQKTIEIESL 1544
Query: 162 SELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSRSADG 221
+E+ N E + ++ + G K+ + + ++ + ++ +
Sbjct: 1545 NEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAE-LET 1603
Query: 222 AKNYFEHEELTV---------------SQLLLCLREGNQKVERLEVALK-----EAKERV 261
K EH L+V S+ L E +K E+ A+K + +E+
Sbjct: 1604 KKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKE 1663
Query: 262 SDFEKKT-SNRSEIETQTEGSTEKEND----EEKGPETVGSEVEALNLQVTSLFKELQEA 316
++K T S+ SE+ T+ + E+E + EEK S+ E L + + A
Sbjct: 1664 EQYKKGTESHLSELNTKLQ---EREREVHILEEKLKSVESSQSETL---IVPRSAKNVAA 1717
Query: 317 HTKLSEAE---LMKKRLQEKCQALER----KNSAIPSELNEKQELVYTNKKLELQVESML 369
+T+ EA+ ++K +EK L+R K + EK+E V ++ ++ Q + L
Sbjct: 1718 YTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERL 1777
Query: 370 SEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEK 429
+++ +AK +++S + LQ +L +++ + + KE K + + L
Sbjct: 1778 IKLEHAEAKQHEDQSMIGHLQ---EELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENV 1834
Query: 430 LELAEKALASKQLQMDEMKQTIAKQEEDL-ETMTILRAQMEVYCSDFHAERAARE 483
+ +K L K+L ++Q I + + L + R +ME S + +A ++
Sbjct: 1835 FDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQ 1889
Score = 51.2 bits (121), Expect = 3e-06
Identities = 105/512 (20%), Positives = 210/512 (41%), Gaps = 97/512 (18%)
Query: 46 ELLTENH--QLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHE 103
E LTE H +L + + + + + + EEL E Q +E+ E + E K++++ E
Sbjct: 1030 ESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEK---EQEVAELKQKILLFGCE 1086
Query: 104 NEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEKADLLGIVSE 163
E++ +E+ LK E +D T + E +++ Q V L ++ L + +
Sbjct: 1087 KEEMNKEITWLK--EEGVKQDTTLN------ELQEQLKQKSAHVNSLAQDETKLKAHLEK 1138
Query: 164 LQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSTGTALSKYRSRSADGAK 223
L++ LN S E++F++ ++ E K
Sbjct: 1139 LEVDLNKS-LKENTFLQEQLVE------------------------------------LK 1161
Query: 224 NYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFE---KKTSNRSEIETQTEG 280
E ++ VS+L L+ +++ + L+ + +++ + + D KK S I+
Sbjct: 1162 MLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICC 1221
Query: 281 STEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERK 340
+ E K E + N + S Q TK+ EA L+K + +A R+
Sbjct: 1222 KKTEALLEAKTNELINISSSKTNA-ILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQ 1280
Query: 341 NSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEH 400
+ E+ L + ++ Q+E ++IK +A E ++ LQ Q
Sbjct: 1281 LT------EEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAA 1334
Query: 401 NNALKTIEELTRKESEKVDRAVL--KELSEK---------------------LELAEK-- 435
+ I +L ++ SE ++ L +EL EK + L+EK
Sbjct: 1335 SEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEA 1394
Query: 436 ALASKQLQMDEMKQTIAKQEEDL---------ETMTILRAQMEVYCSDFHA-ERAAREKI 485
A++S + Q DE K + Q +DL E ++ L Q++ + + F ++ A+ +
Sbjct: 1395 AISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALE-QVDDWSNKFSEWKKKAQSRF 1453
Query: 486 HEEKEQL-ALQLAVLLKENDAFEDGGRQSLME 516
+ + + LQ+ + LK +A+E + +L++
Sbjct: 1454 TQHQNTVKELQIQLELKSKEAYEKDEQINLLK 1485
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 77.4 bits (189), Expect = 3e-14
Identities = 93/425 (21%), Positives = 178/425 (41%), Gaps = 52/425 (12%)
Query: 88 IQSKEAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQV 147
++S E ++ + + E +K+K+EL K +E ++ +L ++
Sbjct: 846 LKSAETEKEMATMKEEFQKIKDELAK----------------------SEAKRKELEEKM 883
Query: 148 VRLQAEKADLLGIVSELQLKLNSSG--SSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTV 205
V L EK DL +LQ++ + G +E+ ++ + + E +KE+ +
Sbjct: 884 VTLLKEKNDL-----QLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEI 938
Query: 206 STG-TALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDF 264
+ TA + K + ELT++++ KV+ L + E ++
Sbjct: 939 NAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKL 998
Query: 265 EKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAE 324
K+ E QT + E D+ T+ L QV L L++ + E
Sbjct: 999 TKEKKALQEAHQQTLDDLQAEEDKVN---TLTKAKIKLEQQVDDLEGSLEQEKKLRMDLE 1055
Query: 325 LMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQAKTEDEKS 384
K++L+ L+ +I NEKQ+L KK E ++ ++ S+I+ EQA +
Sbjct: 1056 RAKRKLEGD---LKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQK 1112
Query: 385 KLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKLELAEKALASKQLQM 444
K+ LQ + L+E A + K+ + R L+E+SE+LE A A S Q++M
Sbjct: 1113 KIKELQARIEE-LEEEIEAERASRAKAEKQRSDLSRE-LEEISERLEEAGGA-TSAQIEM 1169
Query: 445 DEMKQT-IAKQEEDLETMTILRAQMEVYCSDFHAERAA------------REKIHEEKEQ 491
++ ++ K DLE T+ HA+ A ++K+ +EK +
Sbjct: 1170 NKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1229
Query: 492 LALQL 496
+ +++
Sbjct: 1230 MKMEI 1234
Score = 65.5 bits (158), Expect = 1e-10
Identities = 89/449 (19%), Positives = 195/449 (43%), Gaps = 61/449 (13%)
Query: 36 TPEELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAK- 94
T + L ++++L+ + + A ++ + + L+ W +K +E E KEA+
Sbjct: 1423 TKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARS 1482
Query: 95 ----------------ERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQ 138
++L L EN+ L++E+ L + + + ++ + + EQ
Sbjct: 1483 LGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKI-KKQVEQ 1541
Query: 139 EKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHS 198
EK +L+ + +A G + +QL+LN S V+ ++AE + E + ++K +
Sbjct: 1542 EKCELQAALEEAEASLEHEEGKILRIQLELNQVKSE----VDRKIAEKDEE--IDQLKRN 1595
Query: 199 PGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAK 258
R V + + RS + A + E ++++ + L N + A
Sbjct: 1596 --HIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHAN----------RMAA 1643
Query: 259 ERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQ--EA 316
E + ++ + + + + + D ++ V L ++ L L+ E
Sbjct: 1644 EALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTER 1703
Query: 317 HTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIK--M 374
K++E EL+ E+ Q L +N++ L+ T KKLE + M E++ +
Sbjct: 1704 SRKIAEQELLD--ASERVQLLHTQNTS----------LINTKKKLETDISQMQGEMEDIL 1751
Query: 375 EQAKTEDEKSK--LTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKLEL 432
++A+ +EK+K +T M +L +E + + E +K E+ +K+L +L+
Sbjct: 1752 QEARNAEEKAKKAITDAAMMAEELKKEQDTSAHL--ERMKKNMEQ----TVKDLQLRLDE 1805
Query: 433 AEK-ALASKQLQMDEMKQTIAKQEEDLET 460
AE+ AL + Q+ +++ + + E ++E+
Sbjct: 1806 AEQLALKGGKKQIQKLEARVRELEGEVES 1834
Score = 64.7 bits (156), Expect = 2e-10
Identities = 104/492 (21%), Positives = 198/492 (40%), Gaps = 77/492 (15%)
Query: 39 ELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEE--RQFFEIQSK--EAK 94
+L +++KEL +L+E ++ + A EKQ+ + R+ EI + EA
Sbjct: 1109 QLQKKIKELQARIEELEEEIEAERASR--------AKAEKQRSDLSRELEEISERLEEAG 1160
Query: 95 ERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEK 154
A N+K + E K++ E ++ + R + +L Q+ LQ K
Sbjct: 1161 GATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVK 1220
Query: 155 ADLLGIVSELQLKLNSSGSS------------------EDSFVEIRMAEGEAEGSVKEIK 196
L SE++++++ S+ ED E++ E E + + ++
Sbjct: 1221 QKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLT 1280
Query: 197 HSPGPTRTVS--------TGTALSKYRSRSADG-------AKNYFEHEELTVSQLLLCLR 241
G +T S AL SR K E E + L L+
Sbjct: 1281 AQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQ 1340
Query: 242 EGNQKVERLEVALKEAKERVSDFEKKTSN--------RSEIETQTEGSTEKENDEEKGP- 292
+ L +E +E ++ ++ S R++ ET TE+ + +K
Sbjct: 1341 SSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLA 1400
Query: 293 ---ETVGSEVEALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELN 349
+ VEA+N + SL K Q ++ + L +R C AL++K L
Sbjct: 1401 QRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILA 1460
Query: 350 E-KQELVYTNKKLEL---QVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALK 405
E KQ+ T+ +LE + S+ +E+ + E+ +L L+ + L QE ++ +
Sbjct: 1461 EWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTE 1520
Query: 406 TIEELTRK-----------ESEKVD-RAVLKELSEKLELAEKALASKQLQMDEMK----Q 449
I E ++ E EK + +A L+E LE E + QL+++++K +
Sbjct: 1521 QIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDR 1580
Query: 450 TIAKQEEDLETM 461
IA+++E+++ +
Sbjct: 1581 KIAEKDEEIDQL 1592
Score = 47.4 bits (111), Expect = 4e-05
Identities = 56/273 (20%), Positives = 114/273 (41%), Gaps = 31/273 (11%)
Query: 91 KEAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRL 150
++ KE+L + L+ E+ +L+ E++ R AEQE +V L
Sbjct: 1671 EDLKEQLAMVERRANLLQAEIEELRATLEQTERS--------RKIAEQELLDASERVQLL 1722
Query: 151 QAEKADLLGIVSELQLKLNS-SGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSTGT 209
+ L+ +L+ ++ G ED E R AE +A+ ++ T
Sbjct: 1723 HTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAI---------TDAAMMAE 1773
Query: 210 ALSKYRSRSADGAKNYFEHEELTVSQLLLCLRE--------GNQKVERLEVALKEAKERV 261
L K + SA + ++ E TV L L L E G +++++LE ++E + V
Sbjct: 1774 ELKKEQDTSAH-LERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEV 1832
Query: 262 SDFEKKTSNR----SEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAH 317
+K+ + + E + + T + ++ K + V+ L +V S ++ +EA
Sbjct: 1833 ESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAE 1892
Query: 318 TKLSEAELMKKRLQEKCQALERKNSAIPSELNE 350
+ + ++LQ + + E + S++N+
Sbjct: 1893 EQSNTNLAKFRKLQHELEEAEERADIAESQVNK 1925
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 77.4 bits (189), Expect = 3e-14
Identities = 93/425 (21%), Positives = 178/425 (41%), Gaps = 52/425 (12%)
Query: 88 IQSKEAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQV 147
++S E ++ + + E +K+K+EL K +E ++ +L ++
Sbjct: 846 LKSAETEKEMATMKEEFQKIKDELAK----------------------SEAKRKELEEKM 883
Query: 148 VRLQAEKADLLGIVSELQLKLNSSG--SSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTV 205
V L EK DL +LQ++ + G +E+ ++ + + E +KE+ +
Sbjct: 884 VTLLKEKNDL-----QLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEI 938
Query: 206 STG-TALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDF 264
+ TA + K + ELT++++ KV+ L + E ++
Sbjct: 939 NAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKL 998
Query: 265 EKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAE 324
K+ E QT + E D+ T+ L QV L L++ + E
Sbjct: 999 TKEKKALQEAHQQTLDDLQAEEDKVN---TLTKAKIKLEQQVDDLEGSLEQEKKLRMDLE 1055
Query: 325 LMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQAKTEDEKS 384
K++L+ L+ +I NEKQ+L KK E ++ ++ S+I+ EQA +
Sbjct: 1056 RAKRKLEGD---LKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQK 1112
Query: 385 KLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKLELAEKALASKQLQM 444
K+ LQ + L+E A + K+ + R L+E+SE+LE A A S Q++M
Sbjct: 1113 KIKELQARIEE-LEEEIEAERASRAKAEKQRSDLSRE-LEEISERLEEAGGA-TSAQIEM 1169
Query: 445 DEMKQT-IAKQEEDLETMTILRAQMEVYCSDFHAERAA------------REKIHEEKEQ 491
++ ++ K DLE T+ HA+ A ++K+ +EK +
Sbjct: 1170 NKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1229
Query: 492 LALQL 496
+ +++
Sbjct: 1230 MKMEI 1234
Score = 65.5 bits (158), Expect = 1e-10
Identities = 89/449 (19%), Positives = 195/449 (43%), Gaps = 61/449 (13%)
Query: 36 TPEELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAK- 94
T + L ++++L+ + + A ++ + + L+ W +K +E E KEA+
Sbjct: 1423 TKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARS 1482
Query: 95 ----------------ERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQ 138
++L L EN+ L++E+ L + + + ++ + + EQ
Sbjct: 1483 LGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKI-KKQVEQ 1541
Query: 139 EKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHS 198
EK +L+ + +A G + +QL+LN S V+ ++AE + E + ++K +
Sbjct: 1542 EKCELQAALEEAEASLEHEEGKILRIQLELNQVKSE----VDRKIAEKDEE--IDQLKRN 1595
Query: 199 PGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAK 258
R V + + RS + A + E ++++ + L N + A
Sbjct: 1596 --HIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHAN----------RMAA 1643
Query: 259 ERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQ--EA 316
E + ++ + + + + + D ++ V L ++ L L+ E
Sbjct: 1644 EALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTER 1703
Query: 317 HTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIK--M 374
K++E EL+ E+ Q L +N++ L+ T KKLE + M E++ +
Sbjct: 1704 SRKIAEQELLD--ASERVQLLHTQNTS----------LINTKKKLETDISQMQGEMEDIL 1751
Query: 375 EQAKTEDEKSK--LTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKLEL 432
++A+ +EK+K +T M +L +E + + E +K E+ +K+L +L+
Sbjct: 1752 QEARNAEEKAKKAITDAAMMAEELKKEQDTSAHL--ERMKKNMEQ----TVKDLQLRLDE 1805
Query: 433 AEK-ALASKQLQMDEMKQTIAKQEEDLET 460
AE+ AL + Q+ +++ + + E ++E+
Sbjct: 1806 AEQLALKGGKKQIQKLEARVRELEGEVES 1834
Score = 64.7 bits (156), Expect = 2e-10
Identities = 104/492 (21%), Positives = 198/492 (40%), Gaps = 77/492 (15%)
Query: 39 ELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEE--RQFFEIQSK--EAK 94
+L +++KEL +L+E ++ + A EKQ+ + R+ EI + EA
Sbjct: 1109 QLQKKIKELQARIEELEEEIEAERASR--------AKAEKQRSDLSRELEEISERLEEAG 1160
Query: 95 ERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQAEK 154
A N+K + E K++ E ++ + R + +L Q+ LQ K
Sbjct: 1161 GATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVK 1220
Query: 155 ADLLGIVSELQLKLNSSGSS------------------EDSFVEIRMAEGEAEGSVKEIK 196
L SE++++++ S+ ED E++ E E + + ++
Sbjct: 1221 QKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLT 1280
Query: 197 HSPGPTRTVS--------TGTALSKYRSRSADG-------AKNYFEHEELTVSQLLLCLR 241
G +T S AL SR K E E + L L+
Sbjct: 1281 AQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQ 1340
Query: 242 EGNQKVERLEVALKEAKERVSDFEKKTSN--------RSEIETQTEGSTEKENDEEKGP- 292
+ L +E +E ++ ++ S R++ ET TE+ + +K
Sbjct: 1341 SSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLA 1400
Query: 293 ---ETVGSEVEALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELN 349
+ VEA+N + SL K Q ++ + L +R C AL++K L
Sbjct: 1401 QRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILA 1460
Query: 350 E-KQELVYTNKKLEL---QVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALK 405
E KQ+ T+ +LE + S+ +E+ + E+ +L L+ + L QE ++ +
Sbjct: 1461 EWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTE 1520
Query: 406 TIEELTRK-----------ESEKVD-RAVLKELSEKLELAEKALASKQLQMDEMK----Q 449
I E ++ E EK + +A L+E LE E + QL+++++K +
Sbjct: 1521 QIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDR 1580
Query: 450 TIAKQEEDLETM 461
IA+++E+++ +
Sbjct: 1581 KIAEKDEEIDQL 1592
Score = 47.4 bits (111), Expect = 4e-05
Identities = 56/273 (20%), Positives = 114/273 (41%), Gaps = 31/273 (11%)
Query: 91 KEAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRL 150
++ KE+L + L+ E+ +L+ E++ R AEQE +V L
Sbjct: 1671 EDLKEQLAMVERRANLLQAEIEELRATLEQTERS--------RKIAEQELLDASERVQLL 1722
Query: 151 QAEKADLLGIVSELQLKLNS-SGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSTGT 209
+ L+ +L+ ++ G ED E R AE +A+ ++ T
Sbjct: 1723 HTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAI---------TDAAMMAE 1773
Query: 210 ALSKYRSRSADGAKNYFEHEELTVSQLLLCLRE--------GNQKVERLEVALKEAKERV 261
L K + SA + ++ E TV L L L E G +++++LE ++E + V
Sbjct: 1774 ELKKEQDTSAH-LERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEV 1832
Query: 262 SDFEKKTSNR----SEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAH 317
+K+ + + E + + T + ++ K + V+ L +V S ++ +EA
Sbjct: 1833 ESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAE 1892
Query: 318 TKLSEAELMKKRLQEKCQALERKNSAIPSELNE 350
+ + ++LQ + + E + S++N+
Sbjct: 1893 EQSNTNLAKFRKLQHELEEAEERADIAESQVNK 1925
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 77.0 bits (188), Expect = 4e-14
Identities = 92/423 (21%), Positives = 173/423 (40%), Gaps = 48/423 (11%)
Query: 88 IQSKEAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQV 147
++S E ++ + + E EK KEEL K + K + +L ++
Sbjct: 844 LKSAETEKEMANMKEEFEKTKEELAKTEAK----------------------RKELEEKM 881
Query: 148 VRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVST 207
V L EK DL ++Q + +S +E+ ++ + + E +KE+ ++
Sbjct: 882 VTLMQEKNDLQ---LQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINA 938
Query: 208 G-TALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEK 266
TA + K + ELT++++ KV+ L + E ++ K
Sbjct: 939 ELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTK 998
Query: 267 KTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAELM 326
+ E QT + E D+ T+ L QV L L++ + E
Sbjct: 999 EKKALQEAHQQTLDDLQAEEDKVN---TLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERA 1055
Query: 327 KKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQAKTEDEKSKL 386
K++L+ + + I N+KQ+L KK E ++ + S+I+ EQA + K+
Sbjct: 1056 KRKLEGDLKLAQESTMDIE---NDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKI 1112
Query: 387 TVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKLELAEKALASKQLQMDE 446
LQ + L+E A + K+ + R L+E+SE+LE A A S Q++M++
Sbjct: 1113 KELQARIEE-LEEEIEAERASRAKAEKQRSDLSRE-LEEISERLEEAGGA-TSAQIEMNK 1169
Query: 447 MKQT-IAKQEEDLETMTILRAQMEVYCSDFHAERAA------------REKIHEEKEQLA 493
++ K DLE T+ HA+ A ++K+ +EK ++
Sbjct: 1170 KREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMK 1229
Query: 494 LQL 496
+++
Sbjct: 1230 MEI 1232
Score = 65.9 bits (159), Expect = 1e-10
Identities = 90/449 (20%), Positives = 199/449 (44%), Gaps = 61/449 (13%)
Query: 36 TPEELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEK-----------QKEER- 83
T + L ++++L+ + + A ++ + + L+ W +K QKE R
Sbjct: 1421 TKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRS 1480
Query: 84 ---QFFEIQS--KEAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQ 138
+ F+I++ +E+ ++L L EN+ L++E+ L + + + ++ + + EQ
Sbjct: 1481 LSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKI-KKQVEQ 1539
Query: 139 EKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHS 198
EK +L+ + +A G + +QL+LN S V+ ++AE + E + H
Sbjct: 1540 EKSELQAALEEAEASLEHEEGKILRIQLELNQVKSE----VDRKIAEKDEEIDQMKRNH- 1594
Query: 199 PGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAK 258
R V + + RS + A + E ++++ + L N + A
Sbjct: 1595 ---IRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHAN----------RMAA 1641
Query: 259 ERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQ--EA 316
E + ++ + + + + + + D ++ V L ++ L L+ E
Sbjct: 1642 EALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTER 1701
Query: 317 HTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIK--M 374
K++E EL+ E+ Q L +N++ L+ T KKLE + + E++ +
Sbjct: 1702 SRKIAEQELLD--ASERVQLLHTQNTS----------LINTKKKLETDISQIQGEMEDII 1749
Query: 375 EQAKTEDEKSK--LTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKLEL 432
++A+ +EK+K +T M +L +E + + E +K E+ +K+L +L+
Sbjct: 1750 QEARNAEEKAKKAITDAAMMAEELKKEQDTSAHL--ERMKKNLEQ----TVKDLQHRLDE 1803
Query: 433 AEK-ALASKQLQMDEMKQTIAKQEEDLET 460
AE+ AL + Q+ +++ + + E ++E+
Sbjct: 1804 AEQLALKGGKKQIQKLEARVRELEGEVES 1832
Score = 58.9 bits (141), Expect = 1e-08
Identities = 102/484 (21%), Positives = 205/484 (42%), Gaps = 54/484 (11%)
Query: 38 EELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERL 97
++L ++ E+ E L M+ ++A KG E++ + E Q EI++KE +++
Sbjct: 1219 QKLEKEKSEMKMEIDDLASNMETVSKA-KGNLEKMC-----RALEDQLSEIKTKEEEQQR 1272
Query: 98 MA--LSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRA------EAEQEKDQLRTQVVR 149
+ L+ + +L+ E G+ S + E T S+L R + E+ K QL ++
Sbjct: 1273 LINDLTAQRARLQTESGEY---SRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKA 1329
Query: 150 LQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSTGT 209
A L + L +++ E++ A +A V + + + T +
Sbjct: 1330 KSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWR-TKYETDAIQRTE 1388
Query: 210 ALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQK----VERLEVALKEAKERVSDFE 265
L + + + A ++ EH E V+ L + Q+ VE L + ++ + +
Sbjct: 1389 ELEEAKKKLAQRLQDAEEHVE-AVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALD 1447
Query: 266 KKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAEL 325
KK N +I + K+ EE E S+ E+ +L T LFK L + E
Sbjct: 1448 KKQRNFDKILAEW-----KQKCEETHAELEASQKESRSLS-TELFKIKNAYEESLDQLET 1501
Query: 326 MKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKM----EQAKTED 381
+K+ + L+++ S + ++ E + ++ +K++ QVE SE++ +A E
Sbjct: 1502 LKRENKN----LQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEH 1557
Query: 382 EKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKLELAEKALASKQ 441
E+ K+ +Q+ N++ E ++ ++ E++D+ + +E + L ++
Sbjct: 1558 EEGKILRIQLELNQVKSE-------VDRKIAEKDEEIDQMKRNHI-RIVESMQSTLDAEI 1609
Query: 442 LQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAVLLK 501
++ + K E DL M I Q+ HA R A E + + A+ L
Sbjct: 1610 RSRNDAIRLKKKMEGDLNEMEI---QLN------HANRMAAEALRNYRNTQAILKDTQLH 1660
Query: 502 ENDA 505
+DA
Sbjct: 1661 LDDA 1664
Score = 50.8 bits (120), Expect = 3e-06
Identities = 101/523 (19%), Positives = 212/523 (40%), Gaps = 75/523 (14%)
Query: 42 QQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTE-KQKEERQFFEIQSKEAKERLMAL 100
+ + +L E L+EA + ++ ++++ T+ K K E+Q +++ +E+ + +
Sbjct: 991 ETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRM 1050
Query: 101 SHENEKLKEELGKLKGKSERSSEDPTD----DSRLPRAEAEQEKDQLRTQV-----VRLQ 151
E K K E G LK E + + D D +L + E E Q + + ++LQ
Sbjct: 1051 DLERAKRKLE-GDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQ 1109
Query: 152 AEKADLLGIVSELQLKLNSSGSSEDSFVEIRM-AEGEAEGSVKEIKHSPGPTRTVSTGTA 210
+ +L + EL+ ++ + +S + R E E + ++ + G +T
Sbjct: 1110 KKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGG-----ATSAQ 1164
Query: 211 LSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEKKTSN 270
+ + R A+ K + EE T+ + + ++ E E++ + ++
Sbjct: 1165 IEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHAD----SVAELGEQIDNLQRV--- 1217
Query: 271 RSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAELMKKRL 330
+ ++E + + +D ETV L +L +L E TK E + + L
Sbjct: 1218 KQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDL 1277
Query: 331 QEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQAKTEDEKSKLT-VL 389
+ L+ ++ +L+EK LV + + + E+K + + KS L L
Sbjct: 1278 TAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHAL 1337
Query: 390 QMTHNK---LLQEHNNALKTIEEL---------------TRKESEKVDRA-----VLKEL 426
Q + + L +++ + EL T+ E++ + R K+L
Sbjct: 1338 QSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKL 1397
Query: 427 SEKLELAE---KALASKQLQMDEMKQTIAKQEEDL------------------ETMTILR 465
+++L+ AE +A+ +K +++ KQ + + EDL +
Sbjct: 1398 AQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKIL 1457
Query: 466 AQMEVYCSDFHAERAAREKIHEEKEQLALQLAVLLKENDAFED 508
A+ + C + HAE A +K E L+ + L K +A+E+
Sbjct: 1458 AEWKQKCEETHAELEASQK---ESRSLSTE---LFKIKNAYEE 1494
Score = 48.5 bits (114), Expect = 2e-05
Identities = 52/266 (19%), Positives = 113/266 (42%), Gaps = 17/266 (6%)
Query: 91 KEAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRL 150
++ KE+L + L+ E+ +L+ E++ R AEQE +V L
Sbjct: 1669 EDLKEQLAMVERRANLLQAEIEELRATLEQTERS--------RKIAEQELLDASERVQLL 1720
Query: 151 QAEKADLLGIVSELQLKLNS-SGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSTGT 209
+ L+ +L+ ++ G ED E R AE +A+ ++ + + +
Sbjct: 1721 HTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTS 1780
Query: 210 ALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEKKT- 268
A + ++ + +H QL L+ G +++++LE ++E + V +K+
Sbjct: 1781 AHLERMKKNLEQTVKDLQHRLDEAEQL--ALKGGKKQIQKLEARVRELEGEVESEQKRNV 1838
Query: 269 ---SNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAEL 325
+ E + + T + ++ K + V+ L +V S ++ +EA + S L
Sbjct: 1839 EAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQ-SNVNL 1897
Query: 326 MK-KRLQEKCQALERKNSAIPSELNE 350
K +R+Q + + E + S++N+
Sbjct: 1898 SKFRRIQHELEEAEERADIAESQVNK 1923
>gi|46592991 GRIP1 associated protein 1 isoform 1 [Homo sapiens]
Length = 841
Score = 75.9 bits (185), Expect = 1e-13
Identities = 112/510 (21%), Positives = 222/510 (43%), Gaps = 66/510 (12%)
Query: 38 EELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERL 97
+ + Q+ EL T N+QL + ++ N + +++ A+ +K+ + Q +SK+A+E
Sbjct: 11 QRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKV-AYLDKEFSKAQKALSKSKKAQEVE 69
Query: 98 MALSHENEKLKEELGKLKGKSE----RSSEDPTDDSRL--PRAEAEQEKDQLRT------ 145
+ LS ENE L+ KL + E ++S + S+L + EQE QL+
Sbjct: 70 VLLS-ENEMLQ---AKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEGAAGAG 125
Query: 146 ----------QVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEI 195
+++RLQAE L V+ LQ + G F + +G+ G
Sbjct: 126 VAQAGPLVDGELLRLQAENTALQKNVAALQERY---GKEAGKFSAVSEGQGDPPGGPAPT 182
Query: 196 KHSPGPTRTVSTGTALSKYRSR----SADGAKNYFEHEELTVSQLLLCLREGNQKVERLE 251
+P P V + K R G ++ + E + + L L E +K +
Sbjct: 183 VLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESF 242
Query: 252 VALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFK 311
L+ KE + + +R++IE + + + + E+EA N + L
Sbjct: 243 CRLQTEKETLFN-----DSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRD 297
Query: 312 ELQEAHTKLSEA--------ELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLEL 363
+ Q + + A + QE+ + L +N+A+ + L E + T K EL
Sbjct: 298 QRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSL-AALEQIQTAKTQEL 356
Query: 364 -----QVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKV 418
Q + +E++ +QA+ ED + L + L+ ++ L+ ++E+ +++
Sbjct: 357 NMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEK---- 412
Query: 419 DRAVLKELSEKLELAEKALASKQLQMDEM-KQTIAKQEEDLETM--TILRAQMEVYCSDF 475
++L+++L+ A K+ ++ +DE+ +T+ ++ + E + LR + EV
Sbjct: 413 -----EQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRA 467
Query: 476 HAERAAREKIHEEKEQLALQLAVLLKENDA 505
ER RE +HE+K++ +L ++E A
Sbjct: 468 RYERELRE-LHEDKKRQEEELRGQIREEKA 496
Score = 64.7 bits (156), Expect = 2e-10
Identities = 89/472 (18%), Positives = 203/472 (43%), Gaps = 59/472 (12%)
Query: 42 QQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEK--------QKEERQFFEIQSKE- 92
+Q++ LL EN+ L+ ++ Q + +EL+ E+ Q+++ ++ ++ ++
Sbjct: 326 EQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKD 385
Query: 93 ---------------AKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEAE 137
E+L + E E+L +EL + + +E+ + + E
Sbjct: 386 DLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKS 445
Query: 138 QEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKH 197
Q K++L VRL+ EK ++LG+ + + +L + + E E G ++E K
Sbjct: 446 QHKEEL--GAVRLRHEK-EVLGVRARYERELRELHEDK------KRQEEELRGQIREEKA 496
Query: 198 SPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEA 257
T+ + + S DGAK +FE + L Q+ + E ALK+
Sbjct: 497 RTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEESL------QQQQQEQEEALKQC 550
Query: 258 KER-VSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVE-------ALNLQVTSL 309
+E+ ++ + K ++ Q E + E+ + K ++ EV+ L + ++
Sbjct: 551 REQHAAELKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAA 610
Query: 310 FKEL-QEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESM 368
K+L ++ H + A+ +++RLQ+ + ++ L+E + + + + S
Sbjct: 611 LKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSE----MNSPSRTQTGDSSS 666
Query: 369 LSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSE 428
+S + E E S + ++ + Q A EL+ +E ++ + + + E
Sbjct: 667 ISSFSYREILREKESSAVPARSLSSSPQAQPPRPA-----ELSDEEVAELFQRLAETQQE 721
Query: 429 KLELAEKALASKQLQMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERA 480
K L EK + ++ M + + ++ +ET ++ ++++V + H +R+
Sbjct: 722 KWMLEEK-VKHLEVSSASMAEDLCRKSAIIETY-VMDSRIDVSVAAGHTDRS 771
Score = 63.2 bits (152), Expect = 6e-10
Identities = 127/582 (21%), Positives = 224/582 (38%), Gaps = 99/582 (17%)
Query: 39 ELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERLM 98
+L QM++L EN QLKE A G + + +Q++
Sbjct: 102 KLCSQMEQLEQENQQLKEGAAGAGVAQAGPL-----------VDGELLRLQAENT----- 145
Query: 99 ALSHENEKLKEELGKLKGKSERSSED---------PTDDSRLPRAEA----EQEKDQLRT 145
AL L+E GK GK SE PT + +P AE E EK++ R
Sbjct: 146 ALQKNVAALQERYGKEAGKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRL 205
Query: 146 QVVRLQAEKADLLGIVSELQLKL----NSSGSSEDSFVEIRMAE----GEAEGSVKEIKH 197
+LQ ++ S LQ +L ++SF ++ + ++ ++E++
Sbjct: 206 LWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQ 265
Query: 198 SPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLE--VALK 255
K A A+ +EL + L ++ ERLE AL+
Sbjct: 266 --------------RKEADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAAALR 311
Query: 256 EAKERVSDFEKKTSNRSEIETQTEGSTEKEN-------DEEKGPETVGSEVEALNLQVTS 308
+++VS ++ + Q EG + N E+ E+ L Q T
Sbjct: 312 ALQDQVS------IQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTG 365
Query: 309 LFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNE--------KQELVYTNKK 360
L ELQ+ + + K L + Q R NS + +L E QEL K
Sbjct: 366 LAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKS 425
Query: 361 LELQVESMLSEIKMEQAKTEDE-KSKLTVLQMTHNK----LLQEHNNALKTIEELTRKES 415
E + ++ML E+ ME + + + K +L +++ H K + + L+ + E +++
Sbjct: 426 AEKR-KAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQE 484
Query: 416 EKVDRAVLKE--LSEKLELAEKALASKQLQMDEM-------KQTIAKQEEDLETMTILRA 466
E++ + +E + +LE ++ + Q Q+ M ++ + + EE L+ +
Sbjct: 485 EELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEESLQQQQQEQE 544
Query: 467 QMEVYCSDFHAERAAREKIHEEKEQLALQLAVLLKENDAFEDGGRQSLMEMQSRHGARTS 526
+ C + HA A + EE + + QL +E D L + S
Sbjct: 545 EALKQCREQHA--AELKGKEEELQDVRDQLEQAQEERDC-------HLKTISSLKQEVKD 595
Query: 527 DSDQQAYLVQRG-AEDRDWRQQRNIPIHSCPKCGEVLPDIDT 567
D Q L ++G A +D ++Q ++ K E L DI T
Sbjct: 596 TVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDILT 637
Score = 41.6 bits (96), Expect = 0.002
Identities = 87/433 (20%), Positives = 169/433 (39%), Gaps = 92/433 (21%)
Query: 38 EELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKEERQFFEIQSKEAKERL 97
EEL Q++E +L + ++ EEL A + +FE + KEA+E L
Sbjct: 485 EELRGQIREEKARTREL--------ETLQQTVEELQAQVHSMDGAKGWFERRLKEAEESL 536
Query: 98 MALSHENEKL-----KEELGKLKGKSERSSEDPTDDSRLPRAEAEQEKDQLRTQVVRLQA 152
E E+ ++ +LKGK E+E +R Q+ + Q
Sbjct: 537 QQQQQEQEEALKQCREQHAAELKGK-------------------EEELQDVRDQLEQAQE 577
Query: 153 EKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSTGTALS 212
E+ L +S L+ ++ + + R+ E + ++K++K R
Sbjct: 578 ERDCHLKTISSLKQEVKDTVDGQ------RILEKKGSAALKDLKRQLHLER-----KRAD 626
Query: 213 KYRSRSAD---GAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEKKTS 269
K + R D +K+ EEL +S E S +T
Sbjct: 627 KLQERLQDILTNSKSRSGLEELVLS------------------------EMNSPSRTQTG 662
Query: 270 NRSEIETQTEGSTEKENDEEKGP-ETVGSEVEALNLQVTSLF-KELQEAHTKLSEAELMK 327
+ S I + + +E + P ++ S +A + L +E+ E +L+E + K
Sbjct: 663 DSSSISSFSYREILREKESSAVPARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQEK 722
Query: 328 KRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQAKTEDEKSKL- 386
L+EK + LE ++++ +L K ++ T M S I + A ++S L
Sbjct: 723 WMLEEKVKHLEVSSASMAEDLCRKSAIIET--------YVMDSRIDVSVAAGHTDRSGLG 774
Query: 387 TVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKLELAEKALASKQLQMDE 446
+VL+ + +K +E R+ ++K+ + ++L++ + L + Q +
Sbjct: 775 SVLR-----------DLVKPGDENLREMNKKLQNMLEEQLTKNMHLHKDMEVLSQEIVRL 823
Query: 447 MKQTIAKQEEDLE 459
K+ + + DLE
Sbjct: 824 SKECVGPPDPDLE 836
Score = 37.4 bits (85), Expect = 0.038
Identities = 37/160 (23%), Positives = 81/160 (50%), Gaps = 9/160 (5%)
Query: 297 SEVEALNLQVTSLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVY 356
SE E +Q L EL+ + +LS+ EL K ++ +L +K + + E ++ Q+ +
Sbjct: 6 SEEEFQRMQAQLL--ELRTNNYQLSD-ELRKNGVE--LTSLRQKVAYLDKEFSKAQKALS 60
Query: 357 TNKKLELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESE 416
+KK + +VE +LSE +M QAK ++ ++ ++ L+ E + +E+L ++ +
Sbjct: 61 KSKKAQ-EVEVLLSENEMLQAKLHSQEED---FRLQNSTLMAEFSKLCSQMEQLEQENQQ 116
Query: 417 KVDRAVLKELSEKLELAEKALASKQLQMDEMKQTIAKQEE 456
+ A +++ L + L Q + +++ +A +E
Sbjct: 117 LKEGAAGAGVAQAGPLVDGELLRLQAENTALQKNVAALQE 156
Score = 33.9 bits (76), Expect = 0.42
Identities = 57/255 (22%), Positives = 102/255 (40%), Gaps = 36/255 (14%)
Query: 311 KELQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLS 370
K+ QE LSE E+++ +L + + +NS + +E + ++ S +
Sbjct: 63 KKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFS--------------KLCSQME 108
Query: 371 EIKMEQAKTEDEKSKLTVLQ---MTHNKL--LQEHNNALK----TIEELTRKESEKVDRA 421
+++ E + ++ + V Q + +L LQ N AL+ ++E KE+ K
Sbjct: 109 QLEQENQQLKEGAAGAGVAQAGPLVDGELLRLQAENTALQKNVAALQERYGKEAGKFSAV 168
Query: 422 VLKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDL--ETMTILRAQMEVYCSDFHAER 479
+ A LA L E+K + K+E+ L E + L + + S E
Sbjct: 169 SEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEEL 228
Query: 480 AAREKIHEEKEQLALQLAVLLKENDAFEDGGRQSLMEMQSRHG-------ARTSDSDQQA 532
A K+ E+ ++ L E + + R + E+Q R ART Q+
Sbjct: 229 A---KLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQEL 285
Query: 533 YLVQRG-AEDRDWRQ 546
+ AE RD RQ
Sbjct: 286 EAANQSLAELRDQRQ 300
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.307 0.123 0.324
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,679,928
Number of Sequences: 37866
Number of extensions: 947091
Number of successful extensions: 14570
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 306
Number of HSP's successfully gapped in prelim test: 1223
Number of HSP's that attempted gapping in prelim test: 6653
Number of HSP's gapped (non-prelim): 5121
length of query: 577
length of database: 18,247,518
effective HSP length: 108
effective length of query: 469
effective length of database: 14,157,990
effective search space: 6640097310
effective search space used: 6640097310
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.