Search of human proteins with 20127580

Search of human proteins with 20127580

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|20127580 BTB (POZ) domain containing 2 [Homo sapiens]
         (525 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|20127580 BTB (POZ) domain containing 2 [Homo sapiens]             1056   0.0  
gi|13376848 BTB (POZ) domain containing 1 isoform 1 [Homo sapiens]    749   0.0  
gi|59814146 BTB (POZ) domain containing 1 isoform 2 [Homo sapiens]    540   e-154
gi|225543407 BTB domain protein BDPL [Homo sapiens]                   405   e-113
gi|7662402 BTB/POZ domain containing protein 3 isoform a [Homo s...   385   e-107
gi|31317209 BTB/POZ domain containing protein 3 isoform b [Homo ...   385   e-107
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]                    109   7e-24
gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]                    109   7e-24
gi|151108413 BTB (POZ) domain containing 9 isoform a [Homo sapiens]    99   9e-21
gi|151108411 BTB (POZ) domain containing 9 isoform a [Homo sapiens]    99   9e-21
gi|42741669 kelch repeat and BTB (POZ) domain containing 10 [Hom...    86   8e-17
gi|40807500 kelch-like 20 [Homo sapiens]                               84   3e-16
gi|38194229 kelch-like 17 [Homo sapiens]                               81   2e-15
gi|8922528 kelch-like 11 [Homo sapiens]                                77   5e-14
gi|211904190 hypothetical protein LOC149478 [Homo sapiens]             76   7e-14
gi|34101268 kelch-like 8 [Homo sapiens]                                76   7e-14
gi|166235129 kelch-like 3 [Homo sapiens]                               76   7e-14
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]         76   9e-14
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]         76   9e-14
gi|55925604 kelch-like 18 [Homo sapiens]                               75   1e-13
gi|151108435 BTB (POZ) domain containing 9 isoform b [Homo sapiens]    75   2e-13
gi|45593142 kelch repeat and BTB (POZ) domain containing 5 [Homo...    74   4e-13
gi|5174473 intracisternal A particle-promoted polypeptide isofor...    73   6e-13
gi|223890235 intracisternal A particle-promoted polypeptide isof...    73   6e-13
gi|8922854 kelch-like 26 [Homo sapiens]                                72   1e-12
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]             72   1e-12
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]             72   1e-12
gi|227497736 T-cell activation kelch repeat protein [Homo sapiens]     72   2e-12
gi|148664209 kelch-like 10 [Homo sapiens]                              72   2e-12
gi|126116565 MYC binding protein 2 [Homo sapiens]                      70   4e-12

>gi|20127580 BTB (POZ) domain containing 2 [Homo sapiens]
          Length = 525

 Score = 1056 bits (2731), Expect = 0.0
 Identities = 525/525 (100%), Positives = 525/525 (100%)

Query: 1   MAAGGSGGRASCPPGVGVGPGTGGSPGPSANAAATPAPGNAAAAAAAAAAAAAAPGPTPP 60
           MAAGGSGGRASCPPGVGVGPGTGGSPGPSANAAATPAPGNAAAAAAAAAAAAAAPGPTPP
Sbjct: 1   MAAGGSGGRASCPPGVGVGPGTGGSPGPSANAAATPAPGNAAAAAAAAAAAAAAPGPTPP 60

Query: 61  APPGPGTDAQAAGAERAEEAAGPGAAALQREAAYNWQASKPTVQERFAFLFNNEVLCDVH 120
           APPGPGTDAQAAGAERAEEAAGPGAAALQREAAYNWQASKPTVQERFAFLFNNEVLCDVH
Sbjct: 61  APPGPGTDAQAAGAERAEEAAGPGAAALQREAAYNWQASKPTVQERFAFLFNNEVLCDVH 120

Query: 121 FLVGKGLSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIELPDVEPAAFLALLKFLYS 180
           FLVGKGLSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIELPDVEPAAFLALLKFLYS
Sbjct: 121 FLVGKGLSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIELPDVEPAAFLALLKFLYS 180

Query: 181 DEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADNAFMLLTQARLFDEPQLASL 240
           DEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADNAFMLLTQARLFDEPQLASL
Sbjct: 181 DEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADNAFMLLTQARLFDEPQLASL 240

Query: 241 CLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGIREVRLFNAVVRWSEAECQRQQLQ 300
           CLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGIREVRLFNAVVRWSEAECQRQQLQ
Sbjct: 241 CLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGIREVRLFNAVVRWSEAECQRQQLQ 300

Query: 301 VTPENRRKVLGKALGLIRFPLMTIEEFAAGPAQSGILVDREVVSLFLHFTVNPKPRVEFI 360
           VTPENRRKVLGKALGLIRFPLMTIEEFAAGPAQSGILVDREVVSLFLHFTVNPKPRVEFI
Sbjct: 301 VTPENRRKVLGKALGLIRFPLMTIEEFAAGPAQSGILVDREVVSLFLHFTVNPKPRVEFI 360

Query: 361 DRPRCCLRGKECSINRFQQVESRWGYSGTSDRIRFSVNKRIFVVGFGLYGSIHGPTDYQV 420
           DRPRCCLRGKECSINRFQQVESRWGYSGTSDRIRFSVNKRIFVVGFGLYGSIHGPTDYQV
Sbjct: 361 DRPRCCLRGKECSINRFQQVESRWGYSGTSDRIRFSVNKRIFVVGFGLYGSIHGPTDYQV 420

Query: 421 NIQIIHTDSNTVLGQNDTGFSCDGSASTFRVMFKEPVEVLPNVNYTACATLKGPDSHYGT 480
           NIQIIHTDSNTVLGQNDTGFSCDGSASTFRVMFKEPVEVLPNVNYTACATLKGPDSHYGT
Sbjct: 421 NIQIIHTDSNTVLGQNDTGFSCDGSASTFRVMFKEPVEVLPNVNYTACATLKGPDSHYGT 480

Query: 481 KGLRKVTHESPTTGAKTCFTFCYAAGNNNGTSVEDGQIPEVIFYT 525
           KGLRKVTHESPTTGAKTCFTFCYAAGNNNGTSVEDGQIPEVIFYT
Sbjct: 481 KGLRKVTHESPTTGAKTCFTFCYAAGNNNGTSVEDGQIPEVIFYT 525


>gi|13376848 BTB (POZ) domain containing 1 isoform 1 [Homo sapiens]
          Length = 482

 Score =  749 bits (1935), Expect = 0.0
 Identities = 381/491 (77%), Positives = 417/491 (84%), Gaps = 22/491 (4%)

Query: 42  AAAAAAAAAAAAAPGPT-PPAPPGPGTDAQAAGAERAEEAAGPGAAALQREAAYNWQASK 100
           AAA   A+ A A PGP  PP PP P              + GP    LQRE  YNWQA+K
Sbjct: 7   AAAGEQASGAEAEPGPAGPPPPPSP-------------SSLGP-LLPLQREPLYNWQATK 52

Query: 101 PTVQERFAFLFNNEVLCDVHFLVGKGLSS------QRIPAHRFVLAVGSAVFDAMFNGGM 154
            +++ERFAFLFN+E+L DV F++GKG  +      QRIPAHRFVLA GSAVFDAMFNGGM
Sbjct: 53  ASLKERFAFLFNSELLSDVRFVLGKGRGAAAAGGPQRIPAHRFVLAAGSAVFDAMFNGGM 112

Query: 155 ATTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLK 214
           ATTS EIELPDVEPAAFLALL+FLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFL 
Sbjct: 113 ATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLT 172

Query: 215 KNLRADNAFMLLTQARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDT 274
           K+LRADNAFMLLTQARLFDEPQLASLCL+ IDK+T DAI+AEGFTDID+DTL AVLERDT
Sbjct: 173 KHLRADNAFMLLTQARLFDEPQLASLCLDTIDKSTMDAISAEGFTDIDIDTLCAVLERDT 232

Query: 275 LGIREVRLFNAVVRWSEAECQRQQLQVTPENRRKVLGKALGLIRFPLMTIEEFAAGPAQS 334
           L IRE RLF AVVRW+EAECQRQQL VT  N++KVLGKAL LIRFPLMTIEEFAAGPAQS
Sbjct: 233 LSIRESRLFGAVVRWAEAECQRQQLPVTFGNKQKVLGKALSLIRFPLMTIEEFAAGPAQS 292

Query: 335 GILVDREVVSLFLHFTVNPKPRVEFIDRPRCCLRGKECSINRFQQVESRWGYSGTSDRIR 394
           GIL DREVV+LFLHFTVNPKPRVE+IDRPRCCLRGKEC INRFQQVESRWGYSGTSDRIR
Sbjct: 293 GILSDREVVNLFLHFTVNPKPRVEYIDRPRCCLRGKECCINRFQQVESRWGYSGTSDRIR 352

Query: 395 FSVNKRIFVVGFGLYGSIHGPTDYQVNIQIIHTDSNTVLGQNDTGFSCDGSASTFRVMFK 454
           F+VN+RI +VGFGLYGSIHGPTDYQVNIQII  +    LGQNDTGFSCDG+A+TFRVMFK
Sbjct: 353 FTVNRRISIVGFGLYGSIHGPTDYQVNIQIIEYEKKQTLGQNDTGFSCDGTANTFRVMFK 412

Query: 455 EPVEVLPNVNYTACATLKGPDSHYGTKGLRKVTHESPTTGAKTCFTFCYAAGNNNGTSVE 514
           EP+E+LPNV YTACATLKGPDSHYGTKGL+KV HE+P   +KT F F  + GNNNGTS+E
Sbjct: 413 EPIEILPNVCYTACATLKGPDSHYGTKGLKKVVHETP-AASKTVFFFFSSPGNNNGTSIE 471

Query: 515 DGQIPEVIFYT 525
           DGQIPE+IFYT
Sbjct: 472 DGQIPEIIFYT 482


>gi|59814146 BTB (POZ) domain containing 1 isoform 2 [Homo sapiens]
          Length = 385

 Score =  540 bits (1392), Expect = e-154
 Identities = 284/366 (77%), Positives = 307/366 (83%), Gaps = 22/366 (6%)

Query: 42  AAAAAAAAAAAAAPGPT-PPAPPGPGTDAQAAGAERAEEAAGPGAAALQREAAYNWQASK 100
           AAA   A+ A A PGP  PP PP P +              GP    LQRE  YNWQA+K
Sbjct: 7   AAAGEQASGAEAEPGPAGPPPPPSPSS-------------LGP-LLPLQREPLYNWQATK 52

Query: 101 PTVQERFAFLFNNEVLCDVHFLVGKGLSS------QRIPAHRFVLAVGSAVFDAMFNGGM 154
            +++ERFAFLFN+E+L DV F++GKG  +      QRIPAHRFVLA GSAVFDAMFNGGM
Sbjct: 53  ASLKERFAFLFNSELLSDVRFVLGKGRGAAAAGGPQRIPAHRFVLAAGSAVFDAMFNGGM 112

Query: 155 ATTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLK 214
           ATTS EIELPDVEPAAFLALL+FLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFL 
Sbjct: 113 ATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLT 172

Query: 215 KNLRADNAFMLLTQARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDT 274
           K+LRADNAFMLLTQARLFDEPQLASLCL+ IDK+T DAI+AEGFTDID+DTL AVLERDT
Sbjct: 173 KHLRADNAFMLLTQARLFDEPQLASLCLDTIDKSTMDAISAEGFTDIDIDTLCAVLERDT 232

Query: 275 LGIREVRLFNAVVRWSEAECQRQQLQVTPENRRKVLGKALGLIRFPLMTIEEFAAGPAQS 334
           L IRE RLF AVVRW+EAECQRQQL VT  N++KVLGKAL LIRFPLMTIEEFAAGPAQS
Sbjct: 233 LSIRESRLFGAVVRWAEAECQRQQLPVTFGNKQKVLGKALSLIRFPLMTIEEFAAGPAQS 292

Query: 335 GILVDREVVSLFLHFTVNPKPRVEFIDRPRCCLRGKECSINRFQQVESRWGYSGTSDRIR 394
           GIL DREVV+LFLHFTVNPKPRVE+IDRPRCCLRGKEC INRFQQVESRWGYSGTSDRIR
Sbjct: 293 GILSDREVVNLFLHFTVNPKPRVEYIDRPRCCLRGKECCINRFQQVESRWGYSGTSDRIR 352

Query: 395 FSVNKR 400
            S+N R
Sbjct: 353 -SLNMR 357


>gi|225543407 BTB domain protein BDPL [Homo sapiens]
          Length = 485

 Score =  405 bits (1040), Expect = e-113
 Identities = 225/501 (44%), Positives = 308/501 (61%), Gaps = 28/501 (5%)

Query: 28  PSANAAATPAPGNAAAAAAAAAAAAAAPGPTPPAPPGPGTDAQAAGAERAEEAAGPGAAA 87
           P++ AAA  A  NA AA    A   + P    PAPP P       G    E    PG   
Sbjct: 8   PASAAAADLANSNAGAAVGRKAGPRSPPSAPAPAPPPPAPAPPTLGNNHQES---PG--- 61

Query: 88  LQREAAYNWQASKPTVQERFAFLFNNEVLCDVHFLVGKGLSSQRIPAHRFVLAVGSAVFD 147
                   W+  +PT++ER A +FNNE++ DVHF+VG   +++ +PAH++VLAVGS+VF 
Sbjct: 62  --------WRCCRPTLRERNALMFNNELMADVHFVVGPPGATRTVPAHKYVLAVGSSVFY 113

Query: 148 AMFNGGMATTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEA 207
           AMF G +A   +EI +PDVEPAAFL LLK++YSDE+ +  +TV+ TLY AKKY VPAL  
Sbjct: 114 AMFYGDLAEVKSEIHIPDVEPAAFLILLKYMYSDEIDLEADTVLATLYAAKKYIVPALAK 173

Query: 208 HCVEFLKKNLRADNAFMLLTQARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLV 267
            CV FL+ +L A NA +LL+Q+RLF+EP+L   C E ID     A+ +EGF +ID  TL 
Sbjct: 174 ACVNFLETSLEAKNACVLLSQSRLFEEPELTQRCWEVIDAQAEMALRSEGFCEIDRQTLE 233

Query: 268 AVLERDTLGIREVRLFNAVVRWSEAECQRQQLQVTPENRRKVLGKALGLIRFPLMTIEEF 327
            ++ R+ L  +E  +F AV+ W+EAEC+RQ L +TP N+R VLG+AL L+R P MT+EEF
Sbjct: 234 IIVTREALNTKEAVVFEAVLNWAEAECKRQGLPITPRNKRHVLGRALYLVRIPTMTLEEF 293

Query: 328 AAGPAQSGILVDREVVSLFLHFTVNPKPRVEFIDRPRCCLRGKECSINRFQQV---ESRW 384
           A G AQS IL   E  S+FL +T   KPR++F    R  L  + C  +RFQ      ++W
Sbjct: 294 ANGAAQSDILTLEETHSIFLWYTATNKPRLDFPLTKRKGLAPQRC--HRFQSSAYRSNQW 351

Query: 385 GYSGTSDRIRFSVNKRIFVVGFGLYGSIHGPTDYQVNIQIIHTDSNTVLGQNDTGFSCDG 444
            Y G  D I+F+V++R+F+ G GLYGS  G  +Y V I++       VL QN T F  DG
Sbjct: 352 RYRGRCDSIQFAVDRRVFIAGLGLYGSSSGKAEYSVKIELKRL--GVVLAQNLTKFMSDG 409

Query: 445 SASTFRVMFKEPVEVLPNVNYTACATLKGPD-SHYGTKGLRKVTHESPTTGAKTCFTFCY 503
           S++TF V F+ PV+V  +  YTA A L G + S++G +G+ +V         K  F F  
Sbjct: 410 SSNTFPVWFEHPVQVEQDTFYTASAVLDGSELSYFGQEGMTEV------QCGKVAFQFQC 463

Query: 504 AAGNNNGTSVEDGQIPEVIFY 524
           ++ + NGT V+ GQIPE+IFY
Sbjct: 464 SSDSTNGTGVQGGQIPELIFY 484


>gi|7662402 BTB/POZ domain containing protein 3 isoform a [Homo
           sapiens]
          Length = 522

 Score =  385 bits (988), Expect = e-107
 Identities = 202/436 (46%), Positives = 283/436 (64%), Gaps = 14/436 (3%)

Query: 93  AYNWQASKPTVQERFAFLFNNEVLCDVHFLVGKGLSSQRIPAHRFVLAVGSAVFDAMFNG 152
           A NWQ   PT++ER A +FNN+++ DVHF+VG    +QR+P H++VLAVGS+VF AMF G
Sbjct: 96  APNWQGLYPTIRERNAMMFNNDLMADVHFVVGPPGGTQRLPGHKYVLAVGSSVFHAMFYG 155

Query: 153 GMATTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEF 212
            +A    EI +PDVEPAAFLA+LK++Y DE+ +  +TV+ TLY AKKY VP L   CV F
Sbjct: 156 ELAEDKDEIRIPDVEPAAFLAMLKYIYCDEIDLAADTVLATLYAAKKYIVPHLARACVNF 215

Query: 213 LKKNLRADNAFMLLTQARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLER 272
           L+ +L A NA +LL+Q+ LF+EP L   C E ID     A+ +EGF DID  TL ++L R
Sbjct: 216 LETSLSAKNACVLLSQSCLFEEPDLTQRCWEVIDAQAELALKSEGFCDIDFQTLESILRR 275

Query: 273 DTLGIREVRLFNAVVRWSEAECQRQQLQVTPENRRKVLGKALGLIRFPLMTIEEFAAGPA 332
           +TL  +E+ +F A + W+E ECQRQ L ++ EN+RKVLGKAL LIR P M +++FA G A
Sbjct: 276 ETLNAKEIVVFEAALNWAEVECQRQDLALSIENKRKVLGKALYLIRIPTMALDDFANGAA 335

Query: 333 QSGILVDREVVSLFLHFTVNPKPRVEFIDRPRCCLRGKECSINRFQQV---ESRWGYSGT 389
           QSG+L   E   +FL +T   KP ++F+ + R  L  + C  +RFQ      ++W Y G 
Sbjct: 336 QSGVLTLNETNDIFLWYTAAKKPELQFVSKARKGLVPQRC--HRFQSCAYRSNQWRYRGR 393

Query: 390 SDRIRFSVNKRIFVVGFGLYGSIHGPTDYQVNIQIIHTDSNTVLGQNDTGFSCDGSASTF 449
            D I+F+V+KR+F+ GFGLYGS  G  +Y   I++       VLGQN + +  DGS++TF
Sbjct: 394 CDSIQFAVDKRVFIAGFGLYGSSCGSAEYSAKIEL--KRQGVVLGQNLSKYFSDGSSNTF 451

Query: 450 RVMFKEPVEVLPNVNYTACATLKGPD-SHYGTKGLRKVTHESPTTGAKTCFTFCYAAGNN 508
            V F+ PV++ P+  YTA   L G + S++G +G+ +V         K    F  ++ + 
Sbjct: 452 PVWFEYPVQIEPDTFYTASVILDGNELSYFGQEGMTEV------QCGKVTVQFQCSSDST 505

Query: 509 NGTSVEDGQIPEVIFY 524
           NGT V+ GQIPE+IFY
Sbjct: 506 NGTGVQGGQIPELIFY 521


>gi|31317209 BTB/POZ domain containing protein 3 isoform b [Homo
           sapiens]
          Length = 461

 Score =  385 bits (988), Expect = e-107
 Identities = 202/436 (46%), Positives = 283/436 (64%), Gaps = 14/436 (3%)

Query: 93  AYNWQASKPTVQERFAFLFNNEVLCDVHFLVGKGLSSQRIPAHRFVLAVGSAVFDAMFNG 152
           A NWQ   PT++ER A +FNN+++ DVHF+VG    +QR+P H++VLAVGS+VF AMF G
Sbjct: 35  APNWQGLYPTIRERNAMMFNNDLMADVHFVVGPPGGTQRLPGHKYVLAVGSSVFHAMFYG 94

Query: 153 GMATTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEF 212
            +A    EI +PDVEPAAFLA+LK++Y DE+ +  +TV+ TLY AKKY VP L   CV F
Sbjct: 95  ELAEDKDEIRIPDVEPAAFLAMLKYIYCDEIDLAADTVLATLYAAKKYIVPHLARACVNF 154

Query: 213 LKKNLRADNAFMLLTQARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLER 272
           L+ +L A NA +LL+Q+ LF+EP L   C E ID     A+ +EGF DID  TL ++L R
Sbjct: 155 LETSLSAKNACVLLSQSCLFEEPDLTQRCWEVIDAQAELALKSEGFCDIDFQTLESILRR 214

Query: 273 DTLGIREVRLFNAVVRWSEAECQRQQLQVTPENRRKVLGKALGLIRFPLMTIEEFAAGPA 332
           +TL  +E+ +F A + W+E ECQRQ L ++ EN+RKVLGKAL LIR P M +++FA G A
Sbjct: 215 ETLNAKEIVVFEAALNWAEVECQRQDLALSIENKRKVLGKALYLIRIPTMALDDFANGAA 274

Query: 333 QSGILVDREVVSLFLHFTVNPKPRVEFIDRPRCCLRGKECSINRFQQV---ESRWGYSGT 389
           QSG+L   E   +FL +T   KP ++F+ + R  L  + C  +RFQ      ++W Y G 
Sbjct: 275 QSGVLTLNETNDIFLWYTAAKKPELQFVSKARKGLVPQRC--HRFQSCAYRSNQWRYRGR 332

Query: 390 SDRIRFSVNKRIFVVGFGLYGSIHGPTDYQVNIQIIHTDSNTVLGQNDTGFSCDGSASTF 449
            D I+F+V+KR+F+ GFGLYGS  G  +Y   I++       VLGQN + +  DGS++TF
Sbjct: 333 CDSIQFAVDKRVFIAGFGLYGSSCGSAEYSAKIEL--KRQGVVLGQNLSKYFSDGSSNTF 390

Query: 450 RVMFKEPVEVLPNVNYTACATLKGPD-SHYGTKGLRKVTHESPTTGAKTCFTFCYAAGNN 508
            V F+ PV++ P+  YTA   L G + S++G +G+ +V         K    F  ++ + 
Sbjct: 391 PVWFEYPVQIEPDTFYTASVILDGNELSYFGQEGMTEV------QCGKVTVQFQCSSDST 444

Query: 509 NGTSVEDGQIPEVIFY 524
           NGT V+ GQIPE+IFY
Sbjct: 445 NGTGVQGGQIPELIFY 460


>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
          Length = 586

 Score =  109 bits (272), Expect = 7e-24
 Identities = 76/261 (29%), Positives = 131/261 (50%), Gaps = 24/261 (9%)

Query: 114 EVLCDVHFLVGKGLSSQRIPAHRFVLAVGSAVFDAMFNGGMATT-STEIELPDVEPAAFL 172
           + LCDV  +V      ++IPAHR VLA  S  F+ MF   M  + S E+EL D EP    
Sbjct: 41  KTLCDVILMV----QERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIE 96

Query: 173 ALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADNAFMLLTQARLF 232
            L++F Y+  + +    V + L  A +Y +  ++  CV+FLK+ + A N   +   A   
Sbjct: 97  QLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECL 156

Query: 233 DEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGIR-EVRLFNAVVRWSE 291
           D P+L +   + I ++  +    + F  +D+  +  +L +DTL +R E ++++A VRW  
Sbjct: 157 DCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRW-- 214

Query: 292 AECQRQQLQVTPENRRKVLGKALGLIRFPLMTIEEFAAGPAQSGILVD------REVVSL 345
                  L+    NR+  +   L  +RFPL++ + F +   Q+  L+       + V+S 
Sbjct: 215 -------LKYDEPNRQPFMVDILAKVRFPLIS-KNFLSKTVQAEPLIQDNPECLKMVISG 266

Query: 346 FLHFTVNPKPRVEFID--RPR 364
             +  ++P+ R E +D  RPR
Sbjct: 267 MRYHLLSPEDREELVDGTRPR 287


>gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]
          Length = 564

 Score =  109 bits (272), Expect = 7e-24
 Identities = 76/261 (29%), Positives = 131/261 (50%), Gaps = 24/261 (9%)

Query: 114 EVLCDVHFLVGKGLSSQRIPAHRFVLAVGSAVFDAMFNGGMATT-STEIELPDVEPAAFL 172
           + LCDV  +V      ++IPAHR VLA  S  F+ MF   M  + S E+EL D EP    
Sbjct: 19  KTLCDVILMV----QERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIE 74

Query: 173 ALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADNAFMLLTQARLF 232
            L++F Y+  + +    V + L  A +Y +  ++  CV+FLK+ + A N   +   A   
Sbjct: 75  QLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECL 134

Query: 233 DEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGIR-EVRLFNAVVRWSE 291
           D P+L +   + I ++  +    + F  +D+  +  +L +DTL +R E ++++A VRW  
Sbjct: 135 DCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRW-- 192

Query: 292 AECQRQQLQVTPENRRKVLGKALGLIRFPLMTIEEFAAGPAQSGILVD------REVVSL 345
                  L+    NR+  +   L  +RFPL++ + F +   Q+  L+       + V+S 
Sbjct: 193 -------LKYDEPNRQPFMVDILAKVRFPLIS-KNFLSKTVQAEPLIQDNPECLKMVISG 244

Query: 346 FLHFTVNPKPRVEFID--RPR 364
             +  ++P+ R E +D  RPR
Sbjct: 245 MRYHLLSPEDREELVDGTRPR 265


>gi|151108413 BTB (POZ) domain containing 9 isoform a [Homo sapiens]
          Length = 612

 Score = 99.0 bits (245), Expect = 9e-21
 Identities = 69/240 (28%), Positives = 109/240 (45%), Gaps = 21/240 (8%)

Query: 103 VQERFAFLFNNEVLCDVHFLVGKGLSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIE 162
           + E    L   E   DV F+V K    +R PAHR +LA     F A+  GGM  +  E E
Sbjct: 22  LSEHIGALLIGEEYGDVTFVVEK----KRFPAHRVILAARCQYFRALLYGGMRESQPEAE 77

Query: 163 LP--DVEPAAFLALLKFLYSDEVQIGPE---TVMTTLYTAKKYAVPALEAHCVEFLKKNL 217
           +P  D    AF  LLK++Y+    +  E    ++  L  A KY  P LE    E+L   L
Sbjct: 78  IPLQDTTAEAFTMLLKYIYTGRATLTDEKEEVLLDFLSLAHKYGFPELEDSTSEYLCTIL 137

Query: 218 RADNAFMLLTQARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGI 277
              N  M    A L+  P+L  +C   +D+N  + +++EGF  +    L+ ++ RD+   
Sbjct: 138 NIQNVCMTFDVASLYSLPKLTCMCCMFMDRNAQEVLSSEGFLSLSKTALLNIVLRDSFAA 197

Query: 278 REVRLFNAVVRWSEAECQRQQLQVTPENRRKVLGKALGLIRFPLMTIEEFAAGPAQSGIL 337
            E  +F A++ W +             N ++   + +  +R PLM++ E       SG+L
Sbjct: 198 PEKDIFLALLNWCK------------HNSKENHAEIMQAVRLPLMSLTELLNVVRPSGLL 245


>gi|151108411 BTB (POZ) domain containing 9 isoform a [Homo sapiens]
          Length = 612

 Score = 99.0 bits (245), Expect = 9e-21
 Identities = 69/240 (28%), Positives = 109/240 (45%), Gaps = 21/240 (8%)

Query: 103 VQERFAFLFNNEVLCDVHFLVGKGLSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIE 162
           + E    L   E   DV F+V K    +R PAHR +LA     F A+  GGM  +  E E
Sbjct: 22  LSEHIGALLIGEEYGDVTFVVEK----KRFPAHRVILAARCQYFRALLYGGMRESQPEAE 77

Query: 163 LP--DVEPAAFLALLKFLYSDEVQIGPE---TVMTTLYTAKKYAVPALEAHCVEFLKKNL 217
           +P  D    AF  LLK++Y+    +  E    ++  L  A KY  P LE    E+L   L
Sbjct: 78  IPLQDTTAEAFTMLLKYIYTGRATLTDEKEEVLLDFLSLAHKYGFPELEDSTSEYLCTIL 137

Query: 218 RADNAFMLLTQARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGI 277
              N  M    A L+  P+L  +C   +D+N  + +++EGF  +    L+ ++ RD+   
Sbjct: 138 NIQNVCMTFDVASLYSLPKLTCMCCMFMDRNAQEVLSSEGFLSLSKTALLNIVLRDSFAA 197

Query: 278 REVRLFNAVVRWSEAECQRQQLQVTPENRRKVLGKALGLIRFPLMTIEEFAAGPAQSGIL 337
            E  +F A++ W +             N ++   + +  +R PLM++ E       SG+L
Sbjct: 198 PEKDIFLALLNWCK------------HNSKENHAEIMQAVRLPLMSLTELLNVVRPSGLL 245


>gi|42741669 kelch repeat and BTB (POZ) domain containing 10 [Homo
           sapiens]
          Length = 606

 Score = 85.9 bits (211), Expect = 8e-17
 Identities = 64/242 (26%), Positives = 107/242 (44%), Gaps = 16/242 (6%)

Query: 89  QREAAYNWQASKPTV-QERFAFLFNNEVLCDVHFLVGKGLSSQRIPAHRFVLAVGSAVFD 147
           QRE A   +  + T+ Q+    L + +   D     G     + +P HR +L+  S  F 
Sbjct: 4   QRELAEELRLYQSTLLQDGLKDLLDEKKFIDCTLKAG----DKSLPCHRLILSACSPYFR 59

Query: 148 AMFNGGM-ATTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALE 206
             F   +      E+ L +V+PA    ++K+LYS  + +    V      A ++ +P++ 
Sbjct: 60  EYFLSEIDEAKKKEVVLDNVDPAILDLIIKYLYSASIDLNDGNVQDIFALASRFQIPSVF 119

Query: 207 AHCVEFLKKNLRADNAFMLLTQARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTL 266
             CV +L+K L   N   +L    L D P+LA    E +          E F  +    L
Sbjct: 120 TVCVSYLQKRLAPGNCLAILRLGLLLDCPRLAISAREFVSDRFVQICKEEDFMQLSPQEL 179

Query: 267 VAVLERDTLGI-REVRLFNAVVRWSEAECQRQQLQVTPENRRKVLGKALGLIRFPLMTIE 325
           ++V+  D+L + +E  +F AV++W         ++   ENR K L +    IRF LMT +
Sbjct: 180 ISVISNDSLNVEKEEAVFEAVMKW---------VRTDKENRVKNLSEVFDCIRFRLMTEK 230

Query: 326 EF 327
            F
Sbjct: 231 YF 232


>gi|40807500 kelch-like 20 [Homo sapiens]
          Length = 609

 Score = 84.0 bits (206), Expect = 3e-16
 Identities = 66/248 (26%), Positives = 119/248 (47%), Gaps = 21/248 (8%)

Query: 116 LCDVHFLVGKGLSSQRIPAHRFVLAVGSAVFDAMFNGGMATT-STEIELPDVEPAAFLAL 174
           LCDV  +VG    +++I AHR +L+  S  F AMF G +A +  TE+ + D++  A   L
Sbjct: 67  LCDVVLVVG----AKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELL 122

Query: 175 LKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADNAFMLLTQARLFDE 234
           + F Y+ ++ +    V T L  A    +  ++  C EFLK+ L   N   +   A     
Sbjct: 123 IDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIRAFADTHSC 182

Query: 235 PQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGIR-EVRLFNAVVRWSEAE 293
            +L  +  +    N  + + +E F  +  + L+ ++  D L +R E ++FNAV+ W    
Sbjct: 183 RELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAW---- 238

Query: 294 CQRQQLQVTPENRRKVLGKALGLIRFPLMTIEEFAAGPAQSGILVD-----REVVSLFLH 348
                ++ + + RR  L + L  +R PL++  +F  G   S  L+      R++V    +
Sbjct: 239 -----VKYSIQERRPQLPQVLQHVRLPLLS-PKFLVGTVGSDPLIKSDEECRDLVDEAKN 292

Query: 349 FTVNPKPR 356
           + + P+ R
Sbjct: 293 YLLLPQER 300


>gi|38194229 kelch-like 17 [Homo sapiens]
          Length = 642

 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 79/313 (25%), Positives = 130/313 (41%), Gaps = 26/313 (8%)

Query: 38  PGNAAAAAAAAAAAAAAPGPTPPAPPGPGTDAQAAGAERAE----EAAGPGAAALQ---R 90
           P +   A    +    +PGP P APP P     A  AER        A P   A+Q   R
Sbjct: 3   PRSERPAGRTQSPEHGSPGPGPEAPPPPPPQPPAPEAERTRPRQARPAAPMEGAVQLLSR 62

Query: 91  EAAYNWQASKPTVQERFAFLFNNE---VLCDVHFLVGKGLSSQRIPAHRFVLAVGSAVFD 147
           E       SK    + F  +       +LCD+   V    +++ I AH+ VLA  S  F 
Sbjct: 63  EGHSVAHNSKRHYHDAFVAMSRMRQRGLLCDIVLHV----AAKEIRAHKVVLASCSPYFH 118

Query: 148 AMFNGGMATT-STEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALE 206
           AMF   M+ +  T + L D++P A   L++F Y+ E+ +G   V T L  A    +  + 
Sbjct: 119 AMFTNEMSESRQTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVR 178

Query: 207 AHCVEFLKKNLRADNAFMLLTQARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTL 266
             C +FL   L   N   +   A       L       + ++  D    E F  + L  +
Sbjct: 179 DACCKFLLSQLDPSNCLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQV 238

Query: 267 VAVLERDTLGI-REVRLFNAVVRWSEAECQRQQLQVTPENRRKVLGKALGLIRFPLMTIE 325
           + ++  D+L +  E  ++ AV+ W + +          + RR+ + + +  +R PL++  
Sbjct: 239 LELVSSDSLNVPSEEEVYRAVLSWVKHDV---------DARRQHVPRLMKCVRLPLLS-R 288

Query: 326 EFAAGPAQSGILV 338
           +F  G   +  LV
Sbjct: 289 DFLLGHVDAESLV 301


>gi|8922528 kelch-like 11 [Homo sapiens]
          Length = 708

 Score = 76.6 bits (187), Expect = 5e-14
 Identities = 76/289 (26%), Positives = 124/289 (42%), Gaps = 40/289 (13%)

Query: 41  AAAAAAAAAAAAAAP-------GPTPPAPPGPGTDAQAAGAERAEEAAGPGAAALQREA- 92
           AAA AAAAAAAAAA             A    G  A+  G+   +   GPG +A++    
Sbjct: 3   AAAVAAAAAAAAAASLQVLEMESMETAAAGSAGLAAEVRGSGTVDFGPGPGISAMEASGG 62

Query: 93  -----AYNWQASKPTVQERFAFLFNNE-----VLCDVHFLVGKGLSSQRIPAHRFVLAVG 142
                A +++ S    +  +     NE     + CD+    G G   +   AHR VLA  
Sbjct: 63  DPGPEAEDFECSSHCSELSWR---QNEQRRQGLFCDITLCFG-GAGGREFRAHRSVLAAA 118

Query: 143 SAVFDAMFNGGMATT-STEIEL------PDVEPAAFLALLKFLYSDEVQIGPETVMTTLY 195
           +  F  + +G  + + S  +E+      P  EP    A+++++Y+  +++   +V   L 
Sbjct: 119 TEYFTPLLSGQFSESRSGRVEMRKWSSEPGPEPDTVEAVIEYMYTGRIRVSTGSVHEVLE 178

Query: 196 TAKKYAVPALEAHCVEFLKKNLRADNAFMLLTQARLFDEPQLASLCLENIDKNTADAITA 255
            A ++ +  L+  C EFLKK L   N   + + A ++   QLA    + I +N    I  
Sbjct: 179 LADRFLLIRLKEFCGEFLKKKLHLSNCVAIHSLAHMYTLSQLALKAADMIRRNFHKVIQD 238

Query: 256 EGFTDIDLDTLVAVLERDTLGIREVR------LFNAVVRWSEAECQRQQ 298
           E F      TL   L RD L   E+       LF  V++W +   + ++
Sbjct: 239 EEFY-----TLPFHLIRDWLSDLEITVDSEEVLFETVLKWVQRNAEERE 282


>gi|211904190 hypothetical protein LOC149478 [Homo sapiens]
          Length = 291

 Score = 76.3 bits (186), Expect = 7e-14
 Identities = 54/182 (29%), Positives = 86/182 (47%), Gaps = 3/182 (1%)

Query: 110 LFNNEVLCDVHFLVGKGLSSQRIPAHRFVLAVGSAVFDAMFNGGMAT-TSTEIELPDVEP 168
           L NN    DV F+VG+    Q + AHR +LA     F  +          + + L  V  
Sbjct: 22  LVNNPRYSDVCFVVGQ--ERQEVFAHRCLLACRCNFFQRLLGTEPGPGVPSPVVLSTVPT 79

Query: 169 AAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADNAFMLLTQ 228
            AFLA+L+FLY++ V++   +V+  L  A +Y +  L   C++F+ K L  D     L  
Sbjct: 80  EAFLAVLEFLYTNSVKLYRHSVLEVLTAAVEYGLEELRELCLQFVVKVLDVDLVCEALQV 139

Query: 229 ARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGIREVRLFNAVVR 288
           A  F   QL   C+  I+ ++ +A+   GF ++    L+ +L  D L + E  L  A   
Sbjct: 140 AVTFGLGQLQERCVAFIEAHSQEALRTRGFLELSAAALLPLLRSDKLCVDEAELVRAARS 199

Query: 289 WS 290
           W+
Sbjct: 200 WA 201


>gi|34101268 kelch-like 8 [Homo sapiens]
          Length = 620

 Score = 76.3 bits (186), Expect = 7e-14
 Identities = 73/290 (25%), Positives = 118/290 (40%), Gaps = 32/290 (11%)

Query: 111 FNNEVLCDVHFLVGKGLSSQRIPAHRFVLAVGSAVFDAMFNGGMATTS-TEIELPDVEPA 169
           + N  LCDV   VG    S+ I  H+ VLA     F AMF   MA    T IE+ D +  
Sbjct: 61  YENGELCDVTLKVG----SKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGD 116

Query: 170 AFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADNAFMLLTQA 229
           A   L+KF+YS  + +  + V   LY A    V  +   C E++K +    N   +   A
Sbjct: 117 AIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFA 176

Query: 230 RLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGI-REVRLFNAVVR 288
              +   L  +  +    +  + +  E F  +    L  +L    L I  E +++NA ++
Sbjct: 177 ESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIK 236

Query: 289 WSEAECQRQQLQVTPENRRKVLGKALGLIRFPLMTIEEFAAGPAQSGILVDR-------- 340
           W         L   P++  K L + L  +R PL+ ++      A+  I+           
Sbjct: 237 W---------LLANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLD 287

Query: 341 EVVSLFLHFTVNPKPRVEFIDR--PR-------CCLRGKECSINRFQQVE 381
           E  +  LH +    P  E+  R  PR        C+ G+  S + F+ +E
Sbjct: 288 EARNYHLHLSSRAVPDFEYSIRTTPRKHTAGVLFCVGGRGGSGDPFRSIE 337


>gi|166235129 kelch-like 3 [Homo sapiens]
          Length = 587

 Score = 76.3 bits (186), Expect = 7e-14
 Identities = 59/228 (25%), Positives = 102/228 (44%), Gaps = 22/228 (9%)

Query: 110 LFNNEVLCDVHFLVGKGLSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTE-IELPDVEP 168
           L + ++LCDV  +         I AHR VLA  S  F AMF G M+ +  + IE+ DV+ 
Sbjct: 43  LRSKQLLCDVMIVA----EDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDG 98

Query: 169 AAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADNAFMLLTQ 228
                L+ ++Y+ E+++  E V   L  A    +  +  +C +FL+  L   N   +   
Sbjct: 99  QTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAF 158

Query: 229 ARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGI-REVRLFNAVV 287
           A +     L        +++  + +  E F  + LD + +++  D L +  E ++F AV+
Sbjct: 159 ADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVI 218

Query: 288 RWSEAECQRQQLQVTPENRRKVLGKALGLIRFPLM-------TIEEFA 328
            W   E          E R + + K +  +R PL+       T+EE A
Sbjct: 219 SWINYE---------KETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEA 257


>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
          Length = 624

 Score = 75.9 bits (185), Expect = 9e-14
 Identities = 50/192 (26%), Positives = 91/192 (47%), Gaps = 3/192 (1%)

Query: 113 NEVLCDVHFLVG-KGLSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEI-ELPDVEPAA 170
           ++ LCDV   V  +   + +  AH+ VLA  S VF AMF  G+     E+  +  + P  
Sbjct: 73  SQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKV 132

Query: 171 FLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADNAFMLLTQAR 230
              L++F Y+  + +G + V+  +  A  Y + ++   C +FL + L   NA  +   A 
Sbjct: 133 MERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAE 192

Query: 231 LFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGIR-EVRLFNAVVRW 289
                +L     E I  +  +    E F ++    LV ++ RD L +R E  +F+A + W
Sbjct: 193 QIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINW 252

Query: 290 SEAECQRQQLQV 301
            + +C++++  V
Sbjct: 253 VKYDCEQRRFYV 264


>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
          Length = 624

 Score = 75.9 bits (185), Expect = 9e-14
 Identities = 50/192 (26%), Positives = 91/192 (47%), Gaps = 3/192 (1%)

Query: 113 NEVLCDVHFLVG-KGLSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEI-ELPDVEPAA 170
           ++ LCDV   V  +   + +  AH+ VLA  S VF AMF  G+     E+  +  + P  
Sbjct: 73  SQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKV 132

Query: 171 FLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADNAFMLLTQAR 230
              L++F Y+  + +G + V+  +  A  Y + ++   C +FL + L   NA  +   A 
Sbjct: 133 MERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAE 192

Query: 231 LFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGIR-EVRLFNAVVRW 289
                +L     E I  +  +    E F ++    LV ++ RD L +R E  +F+A + W
Sbjct: 193 QIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINW 252

Query: 290 SEAECQRQQLQV 301
            + +C++++  V
Sbjct: 253 VKYDCEQRRFYV 264


>gi|55925604 kelch-like 18 [Homo sapiens]
          Length = 574

 Score = 75.1 bits (183), Expect = 1e-13
 Identities = 70/265 (26%), Positives = 116/265 (43%), Gaps = 32/265 (12%)

Query: 116 LCDVHFLVGKGLSSQRIPAHRFVLAVGSAVFDAMF-NGGMATTSTEIELPDVEPAAFLAL 174
           LCDV   +G      +  AHR VLA     F AMF N  M     EI +  ++P+A  AL
Sbjct: 37  LCDVTLKIG----DHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEAL 92

Query: 175 LKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADNAFMLLTQARLFDE 234
           + F Y+  + I  + V + L  A    + +++  C  FL++ L   N        R F E
Sbjct: 93  INFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCL----GVRQFAE 148

Query: 235 PQLASLCLEN----IDKNTADAITAEGFTDIDLDTLVAVLERDTLGIR-EVRLFNAVVRW 289
             + ++  +     I ++  +   +E F  + L+ ++ ++ RD L ++ E ++F A + W
Sbjct: 149 TMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAW 208

Query: 290 SEAECQRQQLQVTPENRRKVLGKALGLIRFPLMTIEEFAAGPAQSGILVD-----REVVS 344
                    ++   E R   L + L  IR PL    +F +   Q   LV      R++V 
Sbjct: 209 ---------VRYDREQRGPYLPELLSNIRLPLCR-PQFLSDRVQQDDLVRCCHKCRDLVD 258

Query: 345 LFLHFTVNPKPRVE---FIDRPRCC 366
               + + P+ R     F  RPRCC
Sbjct: 259 EAKDYHLMPERRPHLPAFRTRPRCC 283


>gi|151108435 BTB (POZ) domain containing 9 isoform b [Homo sapiens]
          Length = 544

 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 49/181 (27%), Positives = 82/181 (45%), Gaps = 15/181 (8%)

Query: 160 EIELPDVEPAAFLALLKFLYSDEVQIGPE---TVMTTLYTAKKYAVPALEAHCVEFLKKN 216
           EI L D    AF  LLK++Y+    +  E    ++  L  A KY  P LE    E+L   
Sbjct: 9   EIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEVLLDFLSLAHKYGFPELEDSTSEYLCTI 68

Query: 217 LRADNAFMLLTQARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLG 276
           L   N  M    A L+  P+L  +C   +D+N  + +++EGF  +    L+ ++ RD+  
Sbjct: 69  LNIQNVCMTFDVASLYSLPKLTCMCCMFMDRNAQEVLSSEGFLSLSKTALLNIVLRDSFA 128

Query: 277 IREVRLFNAVVRWSEAECQRQQLQVTPENRRKVLGKALGLIRFPLMTIEEFAAGPAQSGI 336
             E  +F A++ W +             N ++   + +  +R PLM++ E       SG+
Sbjct: 129 APEKDIFLALLNWCK------------HNSKENHAEIMQAVRLPLMSLTELLNVVRPSGL 176

Query: 337 L 337
           L
Sbjct: 177 L 177


>gi|45593142 kelch repeat and BTB (POZ) domain containing 5 [Homo
           sapiens]
          Length = 621

 Score = 73.6 bits (179), Expect = 4e-13
 Identities = 49/178 (27%), Positives = 81/178 (45%), Gaps = 5/178 (2%)

Query: 130 QRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIELPDVEPAAFLALLKFLYSDEVQIGPET 189
           +  P HR VLA  S  F A F         E+ L +V P     +L +LY+ E+ +   +
Sbjct: 42  REFPCHRLVLAACSPYFRARFLAEPERAG-ELHLEEVSPDVVAQVLHYLYTSEIALDEAS 100

Query: 190 VMTTLYTAKKYAVPALEAHCVEFLKKNLRADNAFMLLTQARLFDEPQLASLCLENIDKNT 249
           V      A ++ +P++   CV FL+K L   N   +     L D  +LA    + I  + 
Sbjct: 101 VQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAVFRLGLLLDCARLAVAARDFICAHF 160

Query: 250 ADAITAEGFTDIDLDTLVAVLERDTLGI-REVRLFNAVVRWS---EAECQRQQLQVTP 303
                   F  +  D L+A++  D L + +E  +F AV+RW+   +AE Q ++ +  P
Sbjct: 161 TLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAGSGDAEAQAERQRALP 218


>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
           [Homo sapiens]
          Length = 584

 Score = 73.2 bits (178), Expect = 6e-13
 Identities = 59/213 (27%), Positives = 92/213 (43%), Gaps = 15/213 (7%)

Query: 112 NNEVLCDVHFLVGKGLSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTE-IELPDVEPAA 170
           N +  CDV   VG+    +   AHR VLA  S  F A+F GGM  +S + + +  +E   
Sbjct: 32  NGQHFCDVQLQVGQ----ESFKAHRLVLAASSPYFAALFTGGMKESSKDVVPILGIEAGI 87

Query: 171 FLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADNAFMLLTQAR 230
           F  LL F+Y+  V IG   V   +  A    +  +   C EFLK  +   N   +   + 
Sbjct: 88  FQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLNCIGIFQFSE 147

Query: 231 LFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGIR-EVRLFNAVVRW 289
                 L       I  +  +  + E F  +  D L+ +L  + L I  E ++F A ++W
Sbjct: 148 QIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEYQVFLAAMQW 207

Query: 290 SEAECQRQQLQVTPENRRKVLGKALGLIRFPLM 322
              +  +         RRK + + L  IRFPL+
Sbjct: 208 ILKDLGK---------RRKHVVEVLDPIRFPLL 231


>gi|223890235 intracisternal A particle-promoted polypeptide isoform
           2 [Homo sapiens]
          Length = 582

 Score = 73.2 bits (178), Expect = 6e-13
 Identities = 59/213 (27%), Positives = 92/213 (43%), Gaps = 15/213 (7%)

Query: 112 NNEVLCDVHFLVGKGLSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTE-IELPDVEPAA 170
           N +  CDV   VG+    +   AHR VLA  S  F A+F GGM  +S + + +  +E   
Sbjct: 32  NGQHFCDVQLQVGQ----ESFKAHRLVLAASSPYFAALFTGGMKESSKDVVPILGIEAGI 87

Query: 171 FLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADNAFMLLTQAR 230
           F  LL F+Y+  V IG   V   +  A    +  +   C EFLK  +   N   +   + 
Sbjct: 88  FQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLNCIGIFQFSE 147

Query: 231 LFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGIR-EVRLFNAVVRW 289
                 L       I  +  +  + E F  +  D L+ +L  + L I  E ++F A ++W
Sbjct: 148 QIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEYQVFLAAMQW 207

Query: 290 SEAECQRQQLQVTPENRRKVLGKALGLIRFPLM 322
              +  +         RRK + + L  IRFPL+
Sbjct: 208 ILKDLGK---------RRKHVVEVLDPIRFPLL 231


>gi|8922854 kelch-like 26 [Homo sapiens]
          Length = 615

 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 92/335 (27%), Positives = 133/335 (39%), Gaps = 32/335 (9%)

Query: 53  AAPGPTPPAPPGPGTDAQAAGAERAEEAAGPGAAALQREAAYNWQASKPTVQERFAFLFN 112
           A  G +     G G      G ER    A    A    +  ++  +   ++ +  A L  
Sbjct: 2   AESGGSSGGAGGGGAFGAGPGPERPNSTADKNGAL---KCTFSAPSHSTSLLQGLATLRA 58

Query: 113 NEVLCDVHFLVGKGLSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTE-IELPDVEPAAF 171
              L DV   + +    +  PAH+ VLA  S  F AMF GGM   S + IEL  V     
Sbjct: 59  QGQLLDVVLTINR----EAFPAHKVVLAACSDYFRAMFTGGMREASQDVIELKGVSARGL 114

Query: 172 LALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADNAFMLLTQARL 231
             ++ F YS EV +  + V   L  A    +  +   C EFLK  +  +    +   A  
Sbjct: 115 RHIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAAMSVETCLNIGQMATT 174

Query: 232 FDEPQLASLCLENID----KNTADAITAEGFTDIDLDTLVAVLERDTL-GIREVRLFNAV 286
           F    LASL  E++D    ++       E F  + L+ LV  L+ + L    E+ LF A 
Sbjct: 175 F---SLASL-RESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNRLQSCAEIDLFRAA 230

Query: 287 VRWSEAECQRQQLQVTPENRRKVLGKALGLIRFPLMTIEEFAAGPAQSGILVD----REV 342
           VRW         LQ  P  RR      L  IRFPLM   E         I+V+    R+ 
Sbjct: 231 VRW---------LQHDPA-RRPRASHVLCHIRFPLMQSSELVDSVQTLDIMVEDVLCRQY 280

Query: 343 VSLFLHFTVNPKPRVEFIDRPRCCLRGKECSINRF 377
           +    ++ V P  + E +  PR  +R    S+  F
Sbjct: 281 LLEAFNYQVLPFRQHE-MQSPRTAVRSDVPSLVTF 314


>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
          Length = 597

 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 53/218 (24%), Positives = 101/218 (46%), Gaps = 15/218 (6%)

Query: 110 LFNNEVLCDVHFLVGKGLSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTE-IELPDVEP 168
           L +  +LCDV  +         I AHR VLA  S  F AMF G M+ +  + + + +V+ 
Sbjct: 53  LRSQNLLCDVTIVA----EDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDG 108

Query: 169 AAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADNAFMLLTQ 228
                L+ ++Y+ E+Q+  E V   L  A    +  ++  C EFL+  L   N   +   
Sbjct: 109 WTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAF 168

Query: 229 ARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGI-REVRLFNAVV 287
           A +     L +      +++ AD + +E F ++ ++ + +++  D L I  E ++F AV+
Sbjct: 169 ADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVI 228

Query: 288 RWSEAECQRQQLQVTPENRRKVLGKALGLIRFPLMTIE 325
            W   +          + R++ + + +  +R PL+  E
Sbjct: 229 AWVNHD---------KDVRQEFMARLMEHVRLPLLPRE 257


>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
          Length = 593

 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 53/218 (24%), Positives = 101/218 (46%), Gaps = 15/218 (6%)

Query: 110 LFNNEVLCDVHFLVGKGLSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTE-IELPDVEP 168
           L +  +LCDV  +         I AHR VLA  S  F AMF G M+ +  + + + +V+ 
Sbjct: 49  LRSQNLLCDVTIVA----EDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDG 104

Query: 169 AAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADNAFMLLTQ 228
                L+ ++Y+ E+Q+  E V   L  A    +  ++  C EFL+  L   N   +   
Sbjct: 105 WTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAF 164

Query: 229 ARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGI-REVRLFNAVV 287
           A +     L +      +++ AD + +E F ++ ++ + +++  D L I  E ++F AV+
Sbjct: 165 ADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVI 224

Query: 288 RWSEAECQRQQLQVTPENRRKVLGKALGLIRFPLMTIE 325
            W   +          + R++ + + +  +R PL+  E
Sbjct: 225 AWVNHD---------KDVRQEFMARLMEHVRLPLLPRE 253


>gi|227497736 T-cell activation kelch repeat protein [Homo sapiens]
          Length = 601

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 53/223 (23%), Positives = 101/223 (45%), Gaps = 13/223 (5%)

Query: 102 TVQERFAFLFNNEVLCDVHFLVGKGLSSQRIPAHRFVLAVGSAVFDAMFNGGMA-TTSTE 160
           ++ ++   +++   L D+   V  G   +    HR VLA  S  F +MF  G+  +T  E
Sbjct: 34  SILKQLKTMYDEGQLTDIVVEVDHG---KTFSCHRNVLAAISPYFRSMFTSGLTESTQKE 90

Query: 161 IELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRAD 220
           + +  VE  +   +L + Y+  V +    V      A  + +P+++  C +++  +L   
Sbjct: 91  VRIVGVEAESMDLVLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQ 150

Query: 221 NAFMLLTQARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGI-RE 279
           N+  +   A  +   +L     E I K        + F  +  D L+++L+ D L + RE
Sbjct: 151 NSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDRE 210

Query: 280 VRLFNAVVRWSEAECQRQQLQVTPENRRKVLGKALGLIRFPLM 322
             ++ +++RW E E   +++ + PE   K        IRFPLM
Sbjct: 211 EHVYESIIRWFEHEQNEREVHL-PEIFAK-------CIRFPLM 245


>gi|148664209 kelch-like 10 [Homo sapiens]
          Length = 608

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 55/229 (24%), Positives = 99/229 (43%), Gaps = 16/229 (6%)

Query: 116 LCDVHFLVGKGLSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEI-ELPDVEPAAFLAL 174
           LCDV   V    +     AH+ +L   S+ F A+F  G   T  ++  +P + P     +
Sbjct: 38  LCDVVIKV----NGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLI 93

Query: 175 LKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADNAFMLLTQARLFDE 234
           +++ Y+  V I P+ V   L  A ++ +  +   C EFLK  L  DN   +      +  
Sbjct: 94  IEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGICKFTDYYYC 153

Query: 235 PQLASLCLENIDKNTADAITAEG-FTDIDLDTLVAVLERDTLGIR-EVRLFNAVVRWSEA 292
           P+L       I  N  + +     F ++ +  L  ++E+D L ++ E  +F A+++W   
Sbjct: 154 PELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKW--- 210

Query: 293 ECQRQQLQVTPENRRKVLGKALGLIRFPLMTIEEFAAGPAQSGILVDRE 341
                 +   P+NR++ +   L  +R  LM  E F      +  + D E
Sbjct: 211 ------ISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSE 253


>gi|126116565 MYC binding protein 2 [Homo sapiens]
          Length = 4640

 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 50/160 (31%), Positives = 75/160 (46%), Gaps = 19/160 (11%)

Query: 374  INRFQQVESRWGYSGTS-DRIRFSVNKRIFVVGFGLYGSIHGPTDYQVNIQII------- 425
            +NRF+     WGYS  S + IRFS +  I + G GL+G   G  +Y   I++        
Sbjct: 1196 VNRFESHGGGWGYSAHSVEAIRFSADTDILLGGLGLFG---GRGEYTAKIKLFELGPDGG 1252

Query: 426  -HTDSNTVLGQNDT-GFSCDGSASTFRVMFKEPVEVLPNVNYTACATLKGPDSHYGTKGL 483
             H     +L + D   + C  +   + +MF EPV +     Y A A + GP S  G+ G 
Sbjct: 1253 DHETDGDLLAETDVLAYDC-AAREKYAMMFDEPVLLQAGWWYVAWARVSGPSSDCGSHGQ 1311

Query: 484  RKVTHESPTTGAKTCFTFCYAAGNNNGTSVEDGQIPEVIF 523
              +T     T     F F  +  +NNGT V  GQIP++++
Sbjct: 1312 ASIT-----TDDGVVFQFKSSKKSNNGTDVNAGQIPQLLY 1346



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 47/172 (27%), Positives = 75/172 (43%), Gaps = 20/172 (11%)

Query: 367  LRGKECSINRFQQVESRWGYS---GTSDRIRFSVNKR-IFVVGFGLYGSIHGPTDYQVNI 422
            L   + S NRF +      ++   G+ D I FSV+K  I VVGF +YG   G  +Y++ +
Sbjct: 1680 LHSVKASANRFTKTSQGRSWNTGNGSPDAICFSVDKPGIVVVGFSVYGG-GGIHEYELEV 1738

Query: 423  QI---------IHTDSNTVLGQNDTGFSCDGSASTF-RVMFKEPVEVLPNVNYTACATLK 472
             +          H+   T L      ++ D S S    +   + V +  NV Y       
Sbjct: 1739 LVDDSEHAGDSTHSHRWTSLELVKGTYTTDDSPSDIAEIRLDKVVPLKENVKYAVRLRNY 1798

Query: 473  GPDSHYGTKGLRKVTHESPTTGAKTCFTFCYAAGNNNGTSVEDGQIPEVIFY 524
            G  +  G  G+  V      T     FTF   + ++NGT+   GQIP++++Y
Sbjct: 1799 GSRTANGDGGMTTVQCPDGVT-----FTFSTCSLSSNGTNQTRGQIPQILYY 1845


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,568,165
Number of Sequences: 37866
Number of extensions: 1204826
Number of successful extensions: 35448
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 871
Number of HSP's successfully gapped in prelim test: 994
Number of HSP's that attempted gapping in prelim test: 15640
Number of HSP's gapped (non-prelim): 13011
length of query: 525
length of database: 18,247,518
effective HSP length: 107
effective length of query: 418
effective length of database: 14,195,856
effective search space: 5933867808
effective search space used: 5933867808
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.