Guide to the Human Genome
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Search of human proteins with 20127452

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|20127452 thyroid hormone receptor, alpha isoform 2 [Homo
sapiens]
         (490 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|20127452 thyroid hormone receptor, alpha isoform 2 [Homo sapi...   996   0.0  
gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo sapi...   760   0.0  
gi|189491771 thyroid hormone receptor, beta [Homo sapiens]            577   e-165
gi|189491769 thyroid hormone receptor, beta [Homo sapiens]            577   e-165
gi|40806162 thyroid hormone receptor, beta [Homo sapiens]             577   e-165
gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens]     225   8e-59
gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens]   223   2e-58
gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens]    223   2e-58
gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens]     223   2e-58
gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens]   219   3e-57
gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens]     219   3e-57
gi|194294519 nuclear receptor subfamily 1, group H, member 3 iso...   181   1e-45
gi|194294517 nuclear receptor subfamily 1, group H, member 3 iso...   181   1e-45
gi|7706625 retinoic acid receptor, beta isoform 2 [Homo sapiens]      176   3e-44
gi|4826980 nuclear receptor subfamily 1, group H, member 4 [Homo...   166   4e-41
gi|4506755 retinoid X receptor, alpha [Homo sapiens]                  157   3e-38
gi|4826661 constitutive androstane receptor isoform 3 [Homo sapi...   156   5e-38
gi|117938752 constitutive androstane receptor isoform 2 [Homo sa...   152   9e-37
gi|117938729 constitutive androstane receptor isoform 6 [Homo sa...   151   1e-36
gi|117938746 constitutive androstane receptor isoform 7 [Homo sa...   151   1e-36
gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo...   148   1e-35
gi|117938756 constitutive androstane receptor isoform 1 [Homo sa...   148   1e-35
gi|11415052 retinoid X receptor, beta [Homo sapiens]                  144   2e-34
gi|14702164 nuclear receptor subfamily 1, group I, member 2 isof...   142   5e-34
gi|63054845 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo ...   139   6e-33
gi|4507883 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo s...   139   6e-33
gi|27894361 nuclear receptor subfamily 4, group A, member 3 isof...   139   6e-33
gi|27894357 nuclear receptor subfamily 4, group A, member 3 isof...   139   6e-33
gi|27894355 nuclear receptor subfamily 4, group A, member 3 isof...   139   6e-33
gi|223718070 retinoic acid receptor, alpha isoform 4 [Homo sapiens]   137   2e-32

>gi|20127452 thyroid hormone receptor, alpha isoform 2 [Homo
           sapiens]
          Length = 490

 Score =  996 bits (2575), Expect = 0.0
 Identities = 490/490 (100%), Positives = 490/490 (100%)

Query: 1   MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKA 60
           MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKA
Sbjct: 1   MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKA 60

Query: 61  TGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGM 120
           TGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGM
Sbjct: 61  TGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGM 120

Query: 121 AMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA 180
           AMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA
Sbjct: 121 AMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA 180

Query: 181 QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFS 240
           QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFS
Sbjct: 181 QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFS 240

Query: 241 ELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIF 300
           ELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIF
Sbjct: 241 ELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIF 300

Query: 301 ELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI 360
           ELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI
Sbjct: 301 ELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI 360

Query: 361 PHFWPKLLMKEREVQSSILYKGAAAEGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQL 420
           PHFWPKLLMKEREVQSSILYKGAAAEGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQL
Sbjct: 361 PHFWPKLLMKEREVQSSILYKGAAAEGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQL 420

Query: 421 GEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEEEPEVC 480
           GEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEEEPEVC
Sbjct: 421 GEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEEEPEVC 480

Query: 481 EDLAGNAASP 490
           EDLAGNAASP
Sbjct: 481 EDLAGNAASP 490


>gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo
           sapiens]
          Length = 410

 Score =  760 bits (1962), Expect = 0.0
 Identities = 370/375 (98%), Positives = 373/375 (99%)

Query: 1   MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKA 60
           MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKA
Sbjct: 1   MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKA 60

Query: 61  TGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGM 120
           TGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGM
Sbjct: 61  TGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGM 120

Query: 121 AMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA 180
           AMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA
Sbjct: 121 AMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA 180

Query: 181 QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFS 240
           QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFS
Sbjct: 181 QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFS 240

Query: 241 ELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIF 300
           ELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIF
Sbjct: 241 ELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIF 300

Query: 301 ELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI 360
           ELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI
Sbjct: 301 ELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI 360

Query: 361 PHFWPKLLMKEREVQ 375
           PHFWPKLLMK  +++
Sbjct: 361 PHFWPKLLMKVTDLR 375


>gi|189491771 thyroid hormone receptor, beta [Homo sapiens]
          Length = 461

 Score =  577 bits (1487), Expect = e-165
 Identities = 273/335 (81%), Positives = 308/335 (91%)

Query: 41  GYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVID 100
           GYIPSYLDKDE CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHP+YSCKY+  CVID
Sbjct: 95  GYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVID 154

Query: 101 KITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEP 160
           K+TRNQCQ CRFKKCI VGMA DLVLDDSKR+AKRKLIE+NRE+RR+EE+ +S+  +PEP
Sbjct: 155 KVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEP 214

Query: 161 TPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTK 220
           T EEW+LI   TEAH +TNAQGSHWKQ+RKFLP+DIGQ+PIV+ P+G KVDLEAFS FTK
Sbjct: 215 TDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTK 274

Query: 221 IITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEM 280
           IITPAITRVVDFAKKLPMF ELPCEDQIILLKGCCMEIMSLRAAVRYDPES+TLTL+GEM
Sbjct: 275 IITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEM 334

Query: 281 AVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEK 340
           AV R QLKNGGLGVVSDAIF+LG SLS+FNLDDTEVALLQAVLLMS+DR GL CV++IEK
Sbjct: 335 AVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEK 394

Query: 341 SQEAYLLAFEHYVNHRKHNIPHFWPKLLMKEREVQ 375
            Q+++LLAFEHY+N+RKH++ HFWPKLLMK  +++
Sbjct: 395 YQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLR 429


>gi|189491769 thyroid hormone receptor, beta [Homo sapiens]
          Length = 461

 Score =  577 bits (1487), Expect = e-165
 Identities = 273/335 (81%), Positives = 308/335 (91%)

Query: 41  GYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVID 100
           GYIPSYLDKDE CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHP+YSCKY+  CVID
Sbjct: 95  GYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVID 154

Query: 101 KITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEP 160
           K+TRNQCQ CRFKKCI VGMA DLVLDDSKR+AKRKLIE+NRE+RR+EE+ +S+  +PEP
Sbjct: 155 KVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEP 214

Query: 161 TPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTK 220
           T EEW+LI   TEAH +TNAQGSHWKQ+RKFLP+DIGQ+PIV+ P+G KVDLEAFS FTK
Sbjct: 215 TDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTK 274

Query: 221 IITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEM 280
           IITPAITRVVDFAKKLPMF ELPCEDQIILLKGCCMEIMSLRAAVRYDPES+TLTL+GEM
Sbjct: 275 IITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEM 334

Query: 281 AVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEK 340
           AV R QLKNGGLGVVSDAIF+LG SLS+FNLDDTEVALLQAVLLMS+DR GL CV++IEK
Sbjct: 335 AVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEK 394

Query: 341 SQEAYLLAFEHYVNHRKHNIPHFWPKLLMKEREVQ 375
            Q+++LLAFEHY+N+RKH++ HFWPKLLMK  +++
Sbjct: 395 YQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLR 429


>gi|40806162 thyroid hormone receptor, beta [Homo sapiens]
          Length = 461

 Score =  577 bits (1487), Expect = e-165
 Identities = 273/335 (81%), Positives = 308/335 (91%)

Query: 41  GYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVID 100
           GYIPSYLDKDE CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHP+YSCKY+  CVID
Sbjct: 95  GYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVID 154

Query: 101 KITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEP 160
           K+TRNQCQ CRFKKCI VGMA DLVLDDSKR+AKRKLIE+NRE+RR+EE+ +S+  +PEP
Sbjct: 155 KVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEP 214

Query: 161 TPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTK 220
           T EEW+LI   TEAH +TNAQGSHWKQ+RKFLP+DIGQ+PIV+ P+G KVDLEAFS FTK
Sbjct: 215 TDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTK 274

Query: 221 IITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEM 280
           IITPAITRVVDFAKKLPMF ELPCEDQIILLKGCCMEIMSLRAAVRYDPES+TLTL+GEM
Sbjct: 275 IITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEM 334

Query: 281 AVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEK 340
           AV R QLKNGGLGVVSDAIF+LG SLS+FNLDDTEVALLQAVLLMS+DR GL CV++IEK
Sbjct: 335 AVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEK 394

Query: 341 SQEAYLLAFEHYVNHRKHNIPHFWPKLLMKEREVQ 375
            Q+++LLAFEHY+N+RKH++ HFWPKLLMK  +++
Sbjct: 395 YQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLR 429


>gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens]
          Length = 448

 Score =  225 bits (573), Expect = 8e-59
 Identities = 127/331 (38%), Positives = 185/331 (55%), Gaps = 26/331 (7%)

Query: 53  CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRF 112
           C VC DK++GYHY    CEGCKGFFRR+IQKN+   Y+C  D  CVI+K+TRN+CQ CR 
Sbjct: 81  CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM--IYTCHRDKNCVINKVTRNRCQYCRL 138

Query: 113 KKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIAT 172
           +KC  VGM+ + V +D             R +++KE   +   +  E T E  DL     
Sbjct: 139 QKCFEVGMSKESVRND-------------RNKKKKETSKQECTESYEMTAELDDLTEKIR 185

Query: 173 EAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDF 232
           +AH+ T        Q  K+  +      +       ++DL  + +F+++ T  I ++V+F
Sbjct: 186 KAHQETFPSLC---QLGKYTTNSSADHRV-------RLDLGLWDKFSELATKCIIKIVEF 235

Query: 233 AKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGL 292
           AK+LP F+ L   DQI LLK  C++I+ LR   RY PE DT+T S  + + R Q+ N G 
Sbjct: 236 AKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGF 295

Query: 293 GVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHY 352
           G ++D +F     L    +DDTE  LL A+ L+  DR  L    K++K QE  L A + Y
Sbjct: 296 GPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIY 355

Query: 353 VNHRKHNIPHFWPKLLMKEREVQSSILYKGA 383
           +  R+ + PH +PK+LMK  +++ SI  KGA
Sbjct: 356 IRKRRPSKPHMFPKILMKITDLR-SISAKGA 385


>gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
          Length = 462

 Score =  223 bits (569), Expect = 2e-58
 Identities = 124/331 (37%), Positives = 185/331 (55%), Gaps = 26/331 (7%)

Query: 53  CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRF 112
           C VC DK++GYHY    CEGCKGFFRR+IQKN+   Y+C  D  C+I+K+TRN+CQ CR 
Sbjct: 88  CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM--VYTCHRDKNCIINKVTRNRCQYCRL 145

Query: 113 KKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIAT 172
           +KC  VGM+ + V +D             R +++KE       +    TPE  +LI    
Sbjct: 146 QKCFEVGMSKESVRND-------------RNKKKKEVPKPECSESYTLTPEVGELIEKVR 192

Query: 173 EAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDF 232
           +AH+ T        Q  K+  ++  +  +        +D++ + +F+++ T  I + V+F
Sbjct: 193 KAHQETFPALC---QLGKYTTNNSSEQRV-------SLDIDLWDKFSELSTKCIIKTVEF 242

Query: 233 AKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGL 292
           AK+LP F+ L   DQI LLK  C++I+ LR   RY PE DT+T S  + + R Q+ N G 
Sbjct: 243 AKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGF 302

Query: 293 GVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHY 352
           G ++D +F     L    +DD E  LL A+ L+  DR  L   D+++  QE  L A + Y
Sbjct: 303 GPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVY 362

Query: 353 VNHRKHNIPHFWPKLLMKEREVQSSILYKGA 383
           V  R+ + PH +PK+LMK  +++ SI  KGA
Sbjct: 363 VRKRRPSRPHMFPKMLMKITDLR-SISAKGA 392


>gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens]
          Length = 457

 Score =  223 bits (569), Expect = 2e-58
 Identities = 124/331 (37%), Positives = 185/331 (55%), Gaps = 26/331 (7%)

Query: 53  CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRF 112
           C VC DK++GYHY    CEGCKGFFRR+IQKN+   Y+C  D  C+I+K+TRN+CQ CR 
Sbjct: 83  CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM--VYTCHRDKNCIINKVTRNRCQYCRL 140

Query: 113 KKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIAT 172
           +KC  VGM+ + V +D             R +++KE       +    TPE  +LI    
Sbjct: 141 QKCFEVGMSKESVRND-------------RNKKKKEVPKPECSESYTLTPEVGELIEKVR 187

Query: 173 EAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDF 232
           +AH+ T        Q  K+  ++  +  +        +D++ + +F+++ T  I + V+F
Sbjct: 188 KAHQETFPALC---QLGKYTTNNSSEQRV-------SLDIDLWDKFSELSTKCIIKTVEF 237

Query: 233 AKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGL 292
           AK+LP F+ L   DQI LLK  C++I+ LR   RY PE DT+T S  + + R Q+ N G 
Sbjct: 238 AKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGF 297

Query: 293 GVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHY 352
           G ++D +F     L    +DD E  LL A+ L+  DR  L   D+++  QE  L A + Y
Sbjct: 298 GPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVY 357

Query: 353 VNHRKHNIPHFWPKLLMKEREVQSSILYKGA 383
           V  R+ + PH +PK+LMK  +++ SI  KGA
Sbjct: 358 VRKRRPSRPHMFPKMLMKITDLR-SISAKGA 387


>gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
          Length = 462

 Score =  223 bits (569), Expect = 2e-58
 Identities = 124/331 (37%), Positives = 185/331 (55%), Gaps = 26/331 (7%)

Query: 53  CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRF 112
           C VC DK++GYHY    CEGCKGFFRR+IQKN+   Y+C  D  C+I+K+TRN+CQ CR 
Sbjct: 88  CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM--VYTCHRDKNCIINKVTRNRCQYCRL 145

Query: 113 KKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIAT 172
           +KC  VGM+ + V +D             R +++KE       +    TPE  +LI    
Sbjct: 146 QKCFEVGMSKESVRND-------------RNKKKKEVPKPECSESYTLTPEVGELIEKVR 192

Query: 173 EAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDF 232
           +AH+ T        Q  K+  ++  +  +        +D++ + +F+++ T  I + V+F
Sbjct: 193 KAHQETFPALC---QLGKYTTNNSSEQRV-------SLDIDLWDKFSELSTKCIIKTVEF 242

Query: 233 AKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGL 292
           AK+LP F+ L   DQI LLK  C++I+ LR   RY PE DT+T S  + + R Q+ N G 
Sbjct: 243 AKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGF 302

Query: 293 GVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHY 352
           G ++D +F     L    +DD E  LL A+ L+  DR  L   D+++  QE  L A + Y
Sbjct: 303 GPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVY 362

Query: 353 VNHRKHNIPHFWPKLLMKEREVQSSILYKGA 383
           V  R+ + PH +PK+LMK  +++ SI  KGA
Sbjct: 363 VRKRRPSRPHMFPKMLMKITDLR-SISAKGA 392


>gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens]
          Length = 443

 Score =  219 bits (559), Expect = 3e-57
 Identities = 122/331 (36%), Positives = 185/331 (55%), Gaps = 26/331 (7%)

Query: 53  CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRF 112
           C VC DK++GYHY   +CEGCKGFFRR+IQKN+   Y+C  D  C+I+K+TRN+CQ CR 
Sbjct: 79  CFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNM--VYTCHRDKNCIINKVTRNRCQYCRL 136

Query: 113 KKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIAT 172
           +KC  VGM+ + V +D             R +++KE          E +P+  +LI   +
Sbjct: 137 QKCFEVGMSKEAVRND-------------RNKKKKEVKEEGSPDSYELSPQLEELITKVS 183

Query: 173 EAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDF 232
           +AH+ T        Q  K+  +      +       ++DL  + +F+++ T  I ++V+F
Sbjct: 184 KAHQETFPSLC---QLGKYTTNSSADHRV-------QLDLGLWDKFSELATKCIIKIVEF 233

Query: 233 AKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGL 292
           AK+LP F+ L   DQI LLK  C++I+ LR   RY PE DT+T S  + + R Q+ N G 
Sbjct: 234 AKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGF 293

Query: 293 GVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHY 352
           G ++D +F     L    +DDTE  LL A+ L+  DR  L   +K++K QE  L A   Y
Sbjct: 294 GPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLY 353

Query: 353 VNHRKHNIPHFWPKLLMKEREVQSSILYKGA 383
              R+ + P+ +P++LMK  +++  I  KGA
Sbjct: 354 ARRRRPSQPYMFPRMLMKITDLR-GISTKGA 383


>gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens]
          Length = 454

 Score =  219 bits (559), Expect = 3e-57
 Identities = 122/331 (36%), Positives = 185/331 (55%), Gaps = 26/331 (7%)

Query: 53  CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRF 112
           C VC DK++GYHY   +CEGCKGFFRR+IQKN+   Y+C  D  C+I+K+TRN+CQ CR 
Sbjct: 90  CFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNM--VYTCHRDKNCIINKVTRNRCQYCRL 147

Query: 113 KKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIAT 172
           +KC  VGM+ + V +D             R +++KE          E +P+  +LI   +
Sbjct: 148 QKCFEVGMSKEAVRND-------------RNKKKKEVKEEGSPDSYELSPQLEELITKVS 194

Query: 173 EAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDF 232
           +AH+ T        Q  K+  +      +       ++DL  + +F+++ T  I ++V+F
Sbjct: 195 KAHQETFPSLC---QLGKYTTNSSADHRV-------QLDLGLWDKFSELATKCIIKIVEF 244

Query: 233 AKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGL 292
           AK+LP F+ L   DQI LLK  C++I+ LR   RY PE DT+T S  + + R Q+ N G 
Sbjct: 245 AKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGF 304

Query: 293 GVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHY 352
           G ++D +F     L    +DDTE  LL A+ L+  DR  L   +K++K QE  L A   Y
Sbjct: 305 GPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLY 364

Query: 353 VNHRKHNIPHFWPKLLMKEREVQSSILYKGA 383
              R+ + P+ +P++LMK  +++  I  KGA
Sbjct: 365 ARRRRPSQPYMFPRMLMKITDLR-GISTKGA 394


>gi|194294519 nuclear receptor subfamily 1, group H, member 3
           isoform c [Homo sapiens]
          Length = 402

 Score =  181 bits (459), Expect = 1e-45
 Identities = 111/327 (33%), Positives = 174/327 (53%), Gaps = 17/327 (5%)

Query: 50  DEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQL 109
           +E C VCGDKA+G+HY  ++CEGCKGFFRR++ K  H  Y C     C +D   R +CQ 
Sbjct: 50  NELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAH--YICHSGGHCPMDTYMRRKCQE 107

Query: 110 CRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSL----QQRPEPTPEEW 165
           CR +KC   GM  + VL + +++  +KL  Q  E+     +        Q  P+ +PE+ 
Sbjct: 108 CRLRKCRQAGMREECVLSE-EQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQL 166

Query: 166 DLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPA 225
            +I     A +  N +   +  R +  P      P+   P   +   + F+ FT++   +
Sbjct: 167 GMIEKLVAAQQQCNRRS--FSDRLRVTP-----WPMAPDPHSREARQQRFAHFTELAIVS 219

Query: 226 ITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKRE 285
           +  +VDFAK+LP F +L  EDQI LLK   +E+M L  + RY+P S+++T   + +  RE
Sbjct: 220 VQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNRE 279

Query: 286 QLKNGGLGV-VSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEA 344
                GL V   + IFE  ++++   L+D E ALL A+ + S DR  +    ++E+ Q  
Sbjct: 280 DFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHT 339

Query: 345 YLLAFEHYVN-HRKHNIPHFWPKLLMK 370
           Y+ A   YV+ H  H+   F P++LMK
Sbjct: 340 YVEALHAYVSIHHPHDRLMF-PRMLMK 365


>gi|194294517 nuclear receptor subfamily 1, group H, member 3
           isoform a [Homo sapiens]
          Length = 447

 Score =  181 bits (459), Expect = 1e-45
 Identities = 111/327 (33%), Positives = 174/327 (53%), Gaps = 17/327 (5%)

Query: 50  DEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQL 109
           +E C VCGDKA+G+HY  ++CEGCKGFFRR++ K  H  Y C     C +D   R +CQ 
Sbjct: 95  NELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAH--YICHSGGHCPMDTYMRRKCQE 152

Query: 110 CRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSL----QQRPEPTPEEW 165
           CR +KC   GM  + VL + +++  +KL  Q  E+     +        Q  P+ +PE+ 
Sbjct: 153 CRLRKCRQAGMREECVLSE-EQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQL 211

Query: 166 DLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPA 225
            +I     A +  N +   +  R +  P      P+   P   +   + F+ FT++   +
Sbjct: 212 GMIEKLVAAQQQCNRRS--FSDRLRVTP-----WPMAPDPHSREARQQRFAHFTELAIVS 264

Query: 226 ITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKRE 285
           +  +VDFAK+LP F +L  EDQI LLK   +E+M L  + RY+P S+++T   + +  RE
Sbjct: 265 VQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNRE 324

Query: 286 QLKNGGLGV-VSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEA 344
                GL V   + IFE  ++++   L+D E ALL A+ + S DR  +    ++E+ Q  
Sbjct: 325 DFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHT 384

Query: 345 YLLAFEHYVN-HRKHNIPHFWPKLLMK 370
           Y+ A   YV+ H  H+   F P++LMK
Sbjct: 385 YVEALHAYVSIHHPHDRLMF-PRMLMK 410


>gi|7706625 retinoic acid receptor, beta isoform 2 [Homo sapiens]
          Length = 336

 Score =  176 bits (447), Expect = 3e-44
 Identities = 104/295 (35%), Positives = 158/295 (53%), Gaps = 24/295 (8%)

Query: 89  YSCKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKE 148
           Y+C  D  CVI+K+TRN+CQ CR +KC  VGM+ + V +D             R +++KE
Sbjct: 3   YTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRND-------------RNKKKKE 49

Query: 149 EMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGD 208
              +   +  E T E  DL     +AH+ T        Q  K+  +      +       
Sbjct: 50  TSKQECTESYEMTAELDDLTEKIRKAHQETFPSLC---QLGKYTTNSSADHRV------- 99

Query: 209 KVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYD 268
           ++DL  + +F+++ T  I ++V+FAK+LP F+ L   DQI LLK  C++I+ LR   RY 
Sbjct: 100 RLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYT 159

Query: 269 PESDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTD 328
           PE DT+T S  + + R Q+ N G G ++D +F     L    +DDTE  LL A+ L+  D
Sbjct: 160 PEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGD 219

Query: 329 RSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKEREVQSSILYKGA 383
           R  L    K++K QE  L A + Y+  R+ + PH +PK+LMK  +++ SI  KGA
Sbjct: 220 RQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLR-SISAKGA 273


>gi|4826980 nuclear receptor subfamily 1, group H, member 4 [Homo
           sapiens]
          Length = 472

 Score =  166 bits (420), Expect = 4e-41
 Identities = 109/329 (33%), Positives = 167/329 (50%), Gaps = 37/329 (11%)

Query: 50  DEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQL 109
           DE CVVCGD+A+GYHY  +TCEGCKGFFRR+I KN    Y CK    CV+D   R +CQ 
Sbjct: 124 DELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNA--VYKCKNGGNCVMDMYMRRKCQE 181

Query: 110 CRFKKCIAVGMAMDLVLDDSKRVAKR--KLIEQN-----------RERRRKEEMIRSLQQ 156
           CR +KC  +GM  + +L + +  +KR  K ++Q+           R+ R+     +S ++
Sbjct: 182 CRLRKCKEMGMLAECLLTEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTTKSCRE 241

Query: 157 RPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFS 216
           + E TP++  L+H   +++   N Q    +   K L ++                 E F 
Sbjct: 242 KTELTPDQQTLLHFIMDSY---NKQRMPQEITNKILKEEFSAE-------------ENFL 285

Query: 217 EFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTL 276
             T++ T  +  +V+F KKLP F  L  EDQI LLKG  +E M LR+A  ++ +      
Sbjct: 286 ILTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLP---- 341

Query: 277 SGEMAVKREQLKNGGLG-VVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCV 335
           SG   +  E+++N G+       +F   KS+    +   E ALL A++++S DR  +   
Sbjct: 342 SGHSDLLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDR 401

Query: 336 DKIEKSQEAYLLAFEHYVN-HRKHNIPHF 363
           + +EK QE  L   +     H+  N  HF
Sbjct: 402 EAVEKLQEPLLDVLQKLCKIHQPENPQHF 430


>gi|4506755 retinoid X receptor, alpha [Homo sapiens]
          Length = 462

 Score =  157 bits (396), Expect = 3e-38
 Identities = 100/342 (29%), Positives = 172/342 (50%), Gaps = 35/342 (10%)

Query: 30  NGQCSLKTSMSGYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTY 89
           NG   +    SG + S+      C +CGD+++G HY   +CEGCKGFF+RT++K+L  TY
Sbjct: 114 NGVLKVPAHPSGNMASFTK--HICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDL--TY 169

Query: 90  SCKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEE 149
           +C+ +  C+IDK  RN+CQ CR++KC+A+GM  + V +           E+ R + R E 
Sbjct: 170 TCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQE-----------ERQRGKDRNEN 218

Query: 150 MIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDK 209
            + S     E  P E           R   A+ +   +   ++  ++G +P  S P+   
Sbjct: 219 EVESTSSANEDMPVE-----------RILEAELAVEPKTETYVEANMGLNP--SSPN--- 262

Query: 210 VDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDP 269
              +  +   +     +  +V++AK++P FSELP +DQ+ILL+    E++    + R   
Sbjct: 263 ---DPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIA 319

Query: 270 ESDTLTLSGEMAVKREQLKNGGLGVVSDAIF-ELGKSLSAFNLDDTEVALLQAVLLMSTD 328
             D + L+  + V R    + G+G + D +  EL   +    +D TE+  L+A++L + D
Sbjct: 320 VKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPD 379

Query: 329 RSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMK 370
             GL    ++E  +E    + E Y  H+    P  + KLL++
Sbjct: 380 SKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLR 421


>gi|4826661 constitutive androstane receptor isoform 3 [Homo
           sapiens]
          Length = 348

 Score =  156 bits (394), Expect = 5e-38
 Identities = 109/335 (32%), Positives = 161/335 (48%), Gaps = 25/335 (7%)

Query: 48  DKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQC 107
           D+   CVVCGD+ATGYH+  +TCEGCKGFFRRT+ K++ PT  C +   C + K  R  C
Sbjct: 6   DELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPT--CPFAGSCEVSKTQRRHC 63

Query: 108 QLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDL 167
             CR +KC+  GM  D++L            E    RR K+   R+ Q   + + E+ +L
Sbjct: 64  PACRLQKCLDAGMRKDMILS----------AEALALRRAKQAQRRAQQTPVQLSKEQEEL 113

Query: 168 IHIATEAHRSTNAQGSHWKQRRKFLPDD---IGQSPIVSMPDGDKVDLEAFSEFTKIITP 224
           I     AH  T   G+ ++Q  +F P     I   P+ ++       L   + F  I T 
Sbjct: 114 IRTLLGAH--TRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAP----VLPLVTHFADINTF 167

Query: 225 AITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKR 284
            + +V+ F K LP+F  LP EDQI LLKG  +EI  +     +  ++    L G +    
Sbjct: 168 MVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNF-LCGPLRYTI 226

Query: 285 EQLKNGGLGV-VSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQE 343
           E     G  V   + +F    +L    L + E  LL A+ L S DR G+   D+I++ QE
Sbjct: 227 EDGARVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGVTQRDEIDQLQE 286

Query: 344 AYLLAFEHYV--NHRKHNIPHFWPKLLMKEREVQS 376
              L  + Y+    R+      + KLL    E++S
Sbjct: 287 EMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRS 321


>gi|117938752 constitutive androstane receptor isoform 2 [Homo
           sapiens]
          Length = 352

 Score =  152 bits (383), Expect = 9e-37
 Identities = 110/342 (32%), Positives = 165/342 (48%), Gaps = 35/342 (10%)

Query: 48  DKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQC 107
           D+   CVVCGD+ATGYH+  +TCEGCKGFFRRT+ K++ PT  C +   C + K  R  C
Sbjct: 6   DELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPT--CPFAGSCEVSKTQRRHC 63

Query: 108 QLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDL 167
             CR +KC+  GM  D++L            E    RR K+   R+ Q   + + E+ +L
Sbjct: 64  PACRLQKCLDAGMRKDMILS----------AEALALRRAKQAQRRAQQTPVQLSKEQEEL 113

Query: 168 IHIATEAHRSTNAQGSHWKQRRKFLPDD---IGQSPIVSMPDGDKVDLEAFSEFTKIITP 224
           I     AH  T   G+ ++Q  +F P     I   P+ ++       L   + F  I T 
Sbjct: 114 IRTLLGAH--TRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAP----VLPLVTHFADINTF 167

Query: 225 AITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKR 284
            + +V+ F K LP+F  LP EDQI LLKG  +EI  +     +  ++    L G +   R
Sbjct: 168 MVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNF-LCGPL---R 223

Query: 285 EQLKNG-------GLGV-VSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVD 336
             +++G       G  V   + +F    +L    L + E  LL A+ L S DR G+   D
Sbjct: 224 YTIEDGARVSPTVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGVTQRD 283

Query: 337 KIEKSQEAYLLAFEHYV--NHRKHNIPHFWPKLLMKEREVQS 376
           +I++ QE   L  + Y+    R+      + KLL    E++S
Sbjct: 284 EIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRS 325


>gi|117938729 constitutive androstane receptor isoform 6 [Homo
           sapiens]
          Length = 340

 Score =  151 bits (382), Expect = 1e-36
 Identities = 104/315 (33%), Positives = 152/315 (48%), Gaps = 28/315 (8%)

Query: 48  DKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQC 107
           D+   CVVCGD+ATGYH+  +TCEGCKGFFRRT+ K++ PT  C +   C + K  R  C
Sbjct: 6   DELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPT--CPFAGSCEVSKTQRRHC 63

Query: 108 QLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDL 167
             CR +KC+  GM  D++L            E    RR K+   R+ Q   + + E+ +L
Sbjct: 64  PACRLQKCLDAGMRKDMILS----------AEALALRRAKQAQRRAQQTPVQLSKEQEEL 113

Query: 168 IHIATEAHRSTNAQGSHWKQRRKFLPDD---IGQSPIVSMPDGDKVDLEAFSEFTKIITP 224
           I     AH  T   G+ ++Q  +F P     I   P+ ++       L   + F  I T 
Sbjct: 114 IRTLLGAH--TRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAP----VLPLVTHFADINTF 167

Query: 225 AITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKR 284
            + +V+ F K LP+F  LP EDQI LLKG  +EI  +     +  ++    L G +    
Sbjct: 168 MVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNF-LCGPLRYTI 226

Query: 285 EQLKNGGLGV-VSDAIFELGKSLSAFNLDDTEVALLQAVLLMS-----TDRSGLLCVDKI 338
           E     G  V   + +F    +L    L + E  LL A+ L S     TDR G+   D+I
Sbjct: 227 EDGARVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPAPYLTDRPGVTQRDEI 286

Query: 339 EKSQEAYLLAFEHYV 353
           ++ QE   L  + Y+
Sbjct: 287 DQLQEEMALTLQSYI 301


>gi|117938746 constitutive androstane receptor isoform 7 [Homo
           sapiens]
          Length = 339

 Score =  151 bits (381), Expect = 1e-36
 Identities = 104/317 (32%), Positives = 155/317 (48%), Gaps = 33/317 (10%)

Query: 48  DKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQC 107
           D+   CVVCGD+ATGYH+  +TCEGCKGFFRRT+ K++ PT  C +   C + K  R  C
Sbjct: 6   DELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPT--CPFAGSCEVSKTQRRHC 63

Query: 108 QLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDL 167
             CR +KC+  GM  D++L            E    RR K+   R+ Q   + + E+ +L
Sbjct: 64  PACRLQKCLDAGMRKDMILS----------AEALALRRAKQAQRRAQQTPVQLSKEQEEL 113

Query: 168 IHIATEAHRSTNAQGSHWKQRRKFLPDD---IGQSPIVSMPDGDKVDLEAFSEFTKIITP 224
           I     AH  T   G+ ++Q  +F P     I   P+ ++       L   + F  I T 
Sbjct: 114 IRTLLGAH--TRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAP----VLPLVTHFADINTF 167

Query: 225 AITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKR 284
            + +V+ F K LP+F  LP EDQI LLKG  +EI  +     +  ++    L G +   R
Sbjct: 168 MVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNF-LCGPL---R 223

Query: 285 EQLKNG-------GLGV-VSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVD 336
             +++G       G  V   + +F    +L    L + E  LL A+ L S DR G+   D
Sbjct: 224 YTIEDGARVSPTVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGVTQRD 283

Query: 337 KIEKSQEAYLLAFEHYV 353
           +I++ QE   L  + Y+
Sbjct: 284 EIDQLQEEMALTLQSYI 300


>gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo
           sapiens]
          Length = 598

 Score =  148 bits (373), Expect = 1e-35
 Identities = 104/326 (31%), Positives = 158/326 (48%), Gaps = 26/326 (7%)

Query: 53  CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRF 112
           C VCGD A   HY   TCEGCKGFF+RT+QKN    Y C  +  C +DK  RN+CQ CRF
Sbjct: 263 CAVCGDNAACQHYGVRTCEGCKGFFKRTVQKN--AKYVCLANKNCPVDKRRRNRCQYCRF 320

Query: 113 KKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIAT 172
           +KC+AVGM  ++V  DS +  + +L  + +             Q P P      LI    
Sbjct: 321 QKCLAVGMVKEVVRTDSLKGRRGRLPSKPKS-----------PQEPSPPSPPVSLISALV 369

Query: 173 EAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDF 232
            AH  +N   +     R     D   S       GD  D +   +F  ++T ++  +  +
Sbjct: 370 RAHVDSNPAMTSLDYSRFQANPDYQMS-------GD--DTQHIQQFYDLLTGSMEIIRGW 420

Query: 233 AKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGL 292
           A+K+P F++LP  DQ +L +   +E+  LR A R +P    L     + + R Q    G 
Sbjct: 421 AEKIPGFADLPKADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVR-GF 479

Query: 293 GVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHY 352
           G   D+I E   +L   N+D +  + + A L M T+R GL    ++E+ Q   +   + +
Sbjct: 480 GEWIDSIVEFSSNLQNMNIDISAFSCI-AALAMVTERHGLKEPKRVEELQNKIVNCLKDH 538

Query: 353 V--NHRKHNIPHFWPKLLMKEREVQS 376
           V  N+   N P++  KLL K  E+++
Sbjct: 539 VTFNNGGLNRPNYLSKLLGKLPELRT 564


>gi|117938756 constitutive androstane receptor isoform 1 [Homo
           sapiens]
          Length = 357

 Score =  148 bits (373), Expect = 1e-35
 Identities = 111/347 (31%), Positives = 166/347 (47%), Gaps = 40/347 (11%)

Query: 48  DKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQC 107
           D+   CVVCGD+ATGYH+  +TCEGCKGFFRRT+ K++ PT  C +   C + K  R  C
Sbjct: 6   DELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPT--CPFAGSCEVSKTQRRHC 63

Query: 108 QLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDL 167
             CR +KC+  GM  D++L            E    RR K+   R+ Q   + + E+ +L
Sbjct: 64  PACRLQKCLDAGMRKDMILS----------AEALALRRAKQAQRRAQQTPVQLSKEQEEL 113

Query: 168 IHIATEAHRSTNAQGSHWKQRRKFLPDD---IGQSPIVSMPDGDKVDLEAFSEFTKIITP 224
           I     AH  T   G+ ++Q  +F P     I   P+ ++       L   + F  I T 
Sbjct: 114 IRTLLGAH--TRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAP----VLPLVTHFADINTF 167

Query: 225 AITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKR 284
            + +V+ F K LP+F  LP EDQI LLKG  +EI  +     +  ++    L G +   R
Sbjct: 168 MVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNF-LCGPL---R 223

Query: 285 EQLKNG-------GLGV-VSDAIFELGKSLSAFNLDDTEVALLQAVLLMS-----TDRSG 331
             +++G       G  V   + +F    +L    L + E  LL A+ L S     TDR G
Sbjct: 224 YTIEDGARVSPTVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPAPYLTDRPG 283

Query: 332 LLCVDKIEKSQEAYLLAFEHYV--NHRKHNIPHFWPKLLMKEREVQS 376
           +   D+I++ QE   L  + Y+    R+      + KLL    E++S
Sbjct: 284 VTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRS 330


>gi|11415052 retinoid X receptor, beta [Homo sapiens]
          Length = 533

 Score =  144 bits (363), Expect = 2e-34
 Identities = 95/321 (29%), Positives = 159/321 (49%), Gaps = 36/321 (11%)

Query: 53  CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRF 112
           C +CGD+++G HY   +CEGCKGFF+RTI+K+L  TYSC+ +  C +DK  RN+CQ CR+
Sbjct: 205 CAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDL--TYSCRDNKDCTVDKRQRNRCQYCRY 262

Query: 113 KKCIAVGMAMDLVLDDSKRVAKRKLIEQNRER-RRKEEMIRSLQQRPEPTPEEWDL-IHI 170
           +KC+A GM             KR+ +++ R+R + K+         PE  P +  L   +
Sbjct: 263 QKCLATGM-------------KREAVQEERQRGKDKDGDGEGAGGAPEEMPVDRILEAEL 309

Query: 171 ATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVV 230
           A E       +G          P+D    P+ ++      D + F+            +V
Sbjct: 310 AVEQKSDQGVEGPGGTGGSGSSPND----PVTNICQA--ADKQLFT------------LV 351

Query: 231 DFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNG 290
           ++AK++P FS LP +DQ+ILL+    E++    + R     D + L+  + V R    + 
Sbjct: 352 EWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSA 411

Query: 291 GLGVVSDAIF-ELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAF 349
           G+G + D +  EL   +    +D TE+  L+A++L + D  GL    ++E  +E    + 
Sbjct: 412 GVGAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASL 471

Query: 350 EHYVNHRKHNIPHFWPKLLMK 370
           E Y   +       + KLL++
Sbjct: 472 ETYCKQKYPEQQGRFAKLLLR 492


>gi|14702164 nuclear receptor subfamily 1, group I, member 2 isoform
           3 [Homo sapiens]
          Length = 397

 Score =  142 bits (359), Expect = 5e-34
 Identities = 97/318 (30%), Positives = 152/318 (47%), Gaps = 17/318 (5%)

Query: 53  CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKY-DSCCVIDKITRNQCQLCR 111
           C VCGDKATGYH+  +TCEGCKGFFRR +++N      C +    C I + TR QCQ CR
Sbjct: 41  CRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNAR--LRCPFRKGACEITRKTRRQCQACR 98

Query: 112 FKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEM--IRSLQQRPEPTPEEWDLIH 169
            +KC+  GM  ++++ D     +R LI++ +  R   +   ++ L      T E+  +I 
Sbjct: 99  LRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGL------TEEQRMMIR 152

Query: 170 IATEAHRST-NAQGSHWKQRRKFLPDDIGQSPIVS-MPDGDKVDLEAFS---EFTKIITP 224
              +A   T +   SH+K  R  L        + +  P  D    E FS       + T 
Sbjct: 153 ELMDAQMKTFDTTFSHFKNFRVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTY 212

Query: 225 AITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKR 284
               ++ FAK +  F +LP EDQI LLKG   E+  LR    ++ E+ T    G ++   
Sbjct: 213 MFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWE-CGRLSYCL 271

Query: 285 EQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEA 344
           E    G   ++ + + +    L    L + E  L+QA+ L S DR G+L    +++ QE 
Sbjct: 272 EDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQ 331

Query: 345 YLLAFEHYVNHRKHNIPH 362
           + +  + Y+   +    H
Sbjct: 332 FAITLKSYIECNRPQPAH 349


>gi|63054845 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo
           sapiens]
          Length = 427

 Score =  139 bits (350), Expect = 6e-33
 Identities = 102/377 (27%), Positives = 169/377 (44%), Gaps = 61/377 (16%)

Query: 53  CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRF 112
           C VCGD+ATG+H+  +TCEGCKGFFRR++++     ++C ++  C I K  R  CQ CR 
Sbjct: 24  CGVCGDRATGFHFNAMTCEGCKGFFRRSMKRK--ALFTCPFNGDCRITKDNRRHCQACRL 81

Query: 113 KKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIAT 172
           K+C+ +GM  + +L D +   KR++I      +RKEE       RP+ + E+  +I I  
Sbjct: 82  KRCVDIGMMKEFILTDEEVQRKREMI-----LKRKEEEALKDSLRPKLSEEQQRIIAILL 136

Query: 173 EAHRST------------------NAQGSH-----WKQRRKFLPDDIGQSPIVSMPDGDK 209
           +AH  T                  +  GSH      +    F  D         +   D 
Sbjct: 137 DAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDM 196

Query: 210 VDLEAFS-------------------------EFTKIITPAITRVVDFAKKLPMFSELPC 244
           +D  +FS                             +++ +I +V+ FAK +P F +L  
Sbjct: 197 MDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTS 256

Query: 245 EDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKR--EQLKNGGLGVVSDAIFEL 302
           EDQI+LLK   +E++ LR+   +  +  + T   +    R  +  K G    + + + + 
Sbjct: 257 EDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKF 316

Query: 303 GKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPH 362
              L   NL + E  LL A+ ++S DR G+     IE  Q+      + Y+  R H  P 
Sbjct: 317 QVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCR-HPPPG 375

Query: 363 ---FWPKLLMKEREVQS 376
               + K++ K  +++S
Sbjct: 376 SHLLYAKMIQKLADLRS 392


>gi|4507883 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo
           sapiens]
          Length = 427

 Score =  139 bits (350), Expect = 6e-33
 Identities = 102/377 (27%), Positives = 169/377 (44%), Gaps = 61/377 (16%)

Query: 53  CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRF 112
           C VCGD+ATG+H+  +TCEGCKGFFRR++++     ++C ++  C I K  R  CQ CR 
Sbjct: 24  CGVCGDRATGFHFNAMTCEGCKGFFRRSMKRK--ALFTCPFNGDCRITKDNRRHCQACRL 81

Query: 113 KKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIAT 172
           K+C+ +GM  + +L D +   KR++I      +RKEE       RP+ + E+  +I I  
Sbjct: 82  KRCVDIGMMKEFILTDEEVQRKREMI-----LKRKEEEALKDSLRPKLSEEQQRIIAILL 136

Query: 173 EAHRST------------------NAQGSH-----WKQRRKFLPDDIGQSPIVSMPDGDK 209
           +AH  T                  +  GSH      +    F  D         +   D 
Sbjct: 137 DAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDM 196

Query: 210 VDLEAFS-------------------------EFTKIITPAITRVVDFAKKLPMFSELPC 244
           +D  +FS                             +++ +I +V+ FAK +P F +L  
Sbjct: 197 MDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTS 256

Query: 245 EDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKR--EQLKNGGLGVVSDAIFEL 302
           EDQI+LLK   +E++ LR+   +  +  + T   +    R  +  K G    + + + + 
Sbjct: 257 EDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKF 316

Query: 303 GKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPH 362
              L   NL + E  LL A+ ++S DR G+     IE  Q+      + Y+  R H  P 
Sbjct: 317 QVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCR-HPPPG 375

Query: 363 ---FWPKLLMKEREVQS 376
               + K++ K  +++S
Sbjct: 376 SHLLYAKMIQKLADLRS 392


>gi|27894361 nuclear receptor subfamily 4, group A, member 3 isoform
           b [Homo sapiens]
          Length = 637

 Score =  139 bits (350), Expect = 6e-33
 Identities = 94/289 (32%), Positives = 142/289 (49%), Gaps = 24/289 (8%)

Query: 53  CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRF 112
           C VCGD A   HY   TCEGCKGFF+RT+QKN    Y C  +  C +DK  RN+CQ CRF
Sbjct: 303 CAVCGDNAACQHYGVRTCEGCKGFFKRTVQKN--AKYVCLANKNCPVDKRRRNRCQYCRF 360

Query: 113 KKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRP-EPTPEEWDLIHIA 171
           +KC++VGM  ++V  DS +          R  R   +    LQQ P +P+P    +  + 
Sbjct: 361 QKCLSVGMVKEVVRTDSLK---------GRRGRLPSKPKSPLQQEPSQPSPPSPPICMMN 411

Query: 172 TEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVD 231
                 T++        R + P D   +           D E   +F  ++T +I     
Sbjct: 412 ALVRALTDSTPRDLDYSR-YCPTDQAAA---------GTDAEHVQQFYNLLTASIDVSRS 461

Query: 232 FAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGG 291
           +A+K+P F++LP EDQ +L++   +E+  LR ++R +   D       + + R Q    G
Sbjct: 462 WAEKIPGFTDLPKEDQTLLIESAFLELFVLRLSIRSNTAEDKFVFCNGLVLHRLQCLR-G 520

Query: 292 LGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEK 340
            G   D+I +   +L + NLD   +A L A L M T+R GL    ++E+
Sbjct: 521 FGEWLDSIKDFSLNLQSLNLDIQALACLSA-LSMITERHGLKEPKRVEE 568


>gi|27894357 nuclear receptor subfamily 4, group A, member 3 isoform
           a [Homo sapiens]
          Length = 626

 Score =  139 bits (350), Expect = 6e-33
 Identities = 94/289 (32%), Positives = 142/289 (49%), Gaps = 24/289 (8%)

Query: 53  CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRF 112
           C VCGD A   HY   TCEGCKGFF+RT+QKN    Y C  +  C +DK  RN+CQ CRF
Sbjct: 292 CAVCGDNAACQHYGVRTCEGCKGFFKRTVQKN--AKYVCLANKNCPVDKRRRNRCQYCRF 349

Query: 113 KKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRP-EPTPEEWDLIHIA 171
           +KC++VGM  ++V  DS +          R  R   +    LQQ P +P+P    +  + 
Sbjct: 350 QKCLSVGMVKEVVRTDSLK---------GRRGRLPSKPKSPLQQEPSQPSPPSPPICMMN 400

Query: 172 TEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVD 231
                 T++        R + P D   +           D E   +F  ++T +I     
Sbjct: 401 ALVRALTDSTPRDLDYSR-YCPTDQAAA---------GTDAEHVQQFYNLLTASIDVSRS 450

Query: 232 FAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGG 291
           +A+K+P F++LP EDQ +L++   +E+  LR ++R +   D       + + R Q    G
Sbjct: 451 WAEKIPGFTDLPKEDQTLLIESAFLELFVLRLSIRSNTAEDKFVFCNGLVLHRLQCLR-G 509

Query: 292 LGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEK 340
            G   D+I +   +L + NLD   +A L A L M T+R GL    ++E+
Sbjct: 510 FGEWLDSIKDFSLNLQSLNLDIQALACLSA-LSMITERHGLKEPKRVEE 557


>gi|27894355 nuclear receptor subfamily 4, group A, member 3 isoform
           a [Homo sapiens]
          Length = 626

 Score =  139 bits (350), Expect = 6e-33
 Identities = 94/289 (32%), Positives = 142/289 (49%), Gaps = 24/289 (8%)

Query: 53  CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRF 112
           C VCGD A   HY   TCEGCKGFF+RT+QKN    Y C  +  C +DK  RN+CQ CRF
Sbjct: 292 CAVCGDNAACQHYGVRTCEGCKGFFKRTVQKN--AKYVCLANKNCPVDKRRRNRCQYCRF 349

Query: 113 KKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRP-EPTPEEWDLIHIA 171
           +KC++VGM  ++V  DS +          R  R   +    LQQ P +P+P    +  + 
Sbjct: 350 QKCLSVGMVKEVVRTDSLK---------GRRGRLPSKPKSPLQQEPSQPSPPSPPICMMN 400

Query: 172 TEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVD 231
                 T++        R + P D   +           D E   +F  ++T +I     
Sbjct: 401 ALVRALTDSTPRDLDYSR-YCPTDQAAA---------GTDAEHVQQFYNLLTASIDVSRS 450

Query: 232 FAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGG 291
           +A+K+P F++LP EDQ +L++   +E+  LR ++R +   D       + + R Q    G
Sbjct: 451 WAEKIPGFTDLPKEDQTLLIESAFLELFVLRLSIRSNTAEDKFVFCNGLVLHRLQCLR-G 509

Query: 292 LGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEK 340
            G   D+I +   +L + NLD   +A L A L M T+R GL    ++E+
Sbjct: 510 FGEWLDSIKDFSLNLQSLNLDIQALACLSA-LSMITERHGLKEPKRVEE 557


>gi|223718070 retinoic acid receptor, alpha isoform 4 [Homo sapiens]
          Length = 365

 Score =  137 bits (346), Expect = 2e-32
 Identities = 81/246 (32%), Positives = 131/246 (53%), Gaps = 11/246 (4%)

Query: 138 IEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIG 197
           +  +R +++KE       +    TPE  +LI    +AH+ T        Q  K+  ++  
Sbjct: 61  VRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALC---QLGKYTTNNSS 117

Query: 198 QSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCME 257
           +  +        +D++ + +F+++ T  I + V+FAK+LP F+ L   DQI LLK  C++
Sbjct: 118 EQRV-------SLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLD 170

Query: 258 IMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVA 317
           I+ LR   RY PE DT+T S  + + R Q+ N G G ++D +F     L    +DD E  
Sbjct: 171 ILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETG 230

Query: 318 LLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKEREVQSS 377
           LL A+ L+  DR  L   D+++  QE  L A + YV  R+ + PH +PK+LMK  +++ S
Sbjct: 231 LLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLR-S 289

Query: 378 ILYKGA 383
           I  KGA
Sbjct: 290 ISAKGA 295


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.133    0.397 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,240,243
Number of Sequences: 37866
Number of extensions: 977556
Number of successful extensions: 4254
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 123
Number of HSP's successfully gapped in prelim test: 22
Number of HSP's that attempted gapping in prelim test: 3856
Number of HSP's gapped (non-prelim): 219
length of query: 490
length of database: 18,247,518
effective HSP length: 106
effective length of query: 384
effective length of database: 14,233,722
effective search space: 5465749248
effective search space used: 5465749248
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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