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Search of human proteins with 20070328
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|20070328 membrane-spanning 4-domains, subfamily A, member 4
isoform a [Homo sapiens]
(220 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|20070328 membrane-spanning 4-domains, subfamily A, member 4 i... 444 e-125
gi|23110995 membrane-spanning 4-domains, subfamily A, member 4 i... 444 e-125
gi|239755562 PREDICTED: membrane-spanning 4-domains, subfamily A... 330 8e-91
gi|239750062 PREDICTED: membrane-spanning 4-domains, subfamily A... 330 8e-91
gi|239744375 PREDICTED: membrane-spanning 4-domains, subfamily A... 328 2e-90
gi|13899295 membrane-spanning 4-domains, subfamily A, member 8B ... 97 1e-20
gi|73486649 membrane-spanning 4-domains, subfamily A, member 3 i... 91 1e-18
gi|8923206 membrane-spanning 4-domains, subfamily A, member 12 [... 89 4e-18
gi|149588599 membrane-spanning 4-domains, subfamily A, member 15... 82 4e-16
gi|23110997 membrane-spanning 4-domains, subfamily A, member 5 [... 82 5e-16
gi|23110987 membrane-spanning 4-domains, subfamily A, member 1 [... 78 7e-15
gi|23110989 membrane-spanning 4-domains, subfamily A, member 1 [... 78 7e-15
gi|4503677 membrane-spanning 4-domains, subfamily A, member 2 is... 72 3e-13
gi|23238238 membrane-spanning 4-domains, subfamily A, member 6A ... 72 5e-13
gi|119226217 membrane-spanning 4-domains, subfamily A, member 14... 71 6e-13
gi|214831008 membrane-spanning 4-domains, subfamily A, member 2 ... 69 3e-12
gi|169202868 PREDICTED: similar to membrane-spanning 4-domains, ... 68 7e-12
gi|169203526 PREDICTED: similar to membrane-spanning 4-domains, ... 68 7e-12
gi|169202217 PREDICTED: similar to membrane-spanning 4-domains, ... 68 7e-12
gi|23238234 membrane-spanning 4-domains, subfamily A, member 6A ... 67 2e-11
gi|11139299 membrane-spanning 4-domains, subfamily A, member 7 i... 64 1e-10
gi|46249357 membrane-spanning 4-domains, subfamily A, member 7 i... 64 1e-10
gi|73486653 membrane-spanning 4-domains, subfamily A, member 3 i... 62 5e-10
gi|22749421 membrane-spanning 4-domains, subfamily A, member 15 ... 58 7e-09
gi|23238236 membrane-spanning 4-domains, subfamily A, member 6A ... 57 1e-08
gi|119226220 membrane-spanning 4-domains, subfamily A, member 14... 54 1e-07
gi|46249347 membrane-spanning 4-domains, subfamily A, member 7 i... 43 2e-04
gi|46249359 membrane-spanning 4-domains, subfamily A, member 7 i... 43 2e-04
gi|73486651 membrane-spanning 4-domains, subfamily A, member 3 i... 40 0.002
gi|167466260 membrane-spanning 4-domains, subfamily A, member 10... 36 0.029
>gi|20070328 membrane-spanning 4-domains, subfamily A, member 4
isoform a [Homo sapiens]
Length = 220
Score = 444 bits (1143), Expect = e-125
Identities = 220/220 (100%), Positives = 220/220 (100%)
Query: 1 MTTMQGMEQAMPGAGPGVPQLGNMAVIHSHLWKGLQEKFLKGEPKVLGVVQILTALMSLS 60
MTTMQGMEQAMPGAGPGVPQLGNMAVIHSHLWKGLQEKFLKGEPKVLGVVQILTALMSLS
Sbjct: 1 MTTMQGMEQAMPGAGPGVPQLGNMAVIHSHLWKGLQEKFLKGEPKVLGVVQILTALMSLS 60
Query: 61 MGITMMCMASNTYGSNPISVYIGYTIWGSVMFIISGSLSIAAGIRTTKGLVRGSLGMNIT 120
MGITMMCMASNTYGSNPISVYIGYTIWGSVMFIISGSLSIAAGIRTTKGLVRGSLGMNIT
Sbjct: 61 MGITMMCMASNTYGSNPISVYIGYTIWGSVMFIISGSLSIAAGIRTTKGLVRGSLGMNIT 120
Query: 121 SSVLAASGILINTFSLAFYSFHHPYCNYYGNSNNCHGTMSILMGLDGMVLLLSVLEFCIA 180
SSVLAASGILINTFSLAFYSFHHPYCNYYGNSNNCHGTMSILMGLDGMVLLLSVLEFCIA
Sbjct: 121 SSVLAASGILINTFSLAFYSFHHPYCNYYGNSNNCHGTMSILMGLDGMVLLLSVLEFCIA 180
Query: 181 VSLSAFGCKVLCCTPGGVVLILPSHSHMAETASPTPLNEV 220
VSLSAFGCKVLCCTPGGVVLILPSHSHMAETASPTPLNEV
Sbjct: 181 VSLSAFGCKVLCCTPGGVVLILPSHSHMAETASPTPLNEV 220
>gi|23110995 membrane-spanning 4-domains, subfamily A, member 4
isoform b [Homo sapiens]
Length = 239
Score = 444 bits (1143), Expect = e-125
Identities = 220/220 (100%), Positives = 220/220 (100%)
Query: 1 MTTMQGMEQAMPGAGPGVPQLGNMAVIHSHLWKGLQEKFLKGEPKVLGVVQILTALMSLS 60
MTTMQGMEQAMPGAGPGVPQLGNMAVIHSHLWKGLQEKFLKGEPKVLGVVQILTALMSLS
Sbjct: 20 MTTMQGMEQAMPGAGPGVPQLGNMAVIHSHLWKGLQEKFLKGEPKVLGVVQILTALMSLS 79
Query: 61 MGITMMCMASNTYGSNPISVYIGYTIWGSVMFIISGSLSIAAGIRTTKGLVRGSLGMNIT 120
MGITMMCMASNTYGSNPISVYIGYTIWGSVMFIISGSLSIAAGIRTTKGLVRGSLGMNIT
Sbjct: 80 MGITMMCMASNTYGSNPISVYIGYTIWGSVMFIISGSLSIAAGIRTTKGLVRGSLGMNIT 139
Query: 121 SSVLAASGILINTFSLAFYSFHHPYCNYYGNSNNCHGTMSILMGLDGMVLLLSVLEFCIA 180
SSVLAASGILINTFSLAFYSFHHPYCNYYGNSNNCHGTMSILMGLDGMVLLLSVLEFCIA
Sbjct: 140 SSVLAASGILINTFSLAFYSFHHPYCNYYGNSNNCHGTMSILMGLDGMVLLLSVLEFCIA 199
Query: 181 VSLSAFGCKVLCCTPGGVVLILPSHSHMAETASPTPLNEV 220
VSLSAFGCKVLCCTPGGVVLILPSHSHMAETASPTPLNEV
Sbjct: 200 VSLSAFGCKVLCCTPGGVVLILPSHSHMAETASPTPLNEV 239
>gi|239755562 PREDICTED: membrane-spanning 4-domains, subfamily A,
member 4E isoform 1 [Homo sapiens]
Length = 243
Score = 330 bits (845), Expect = 8e-91
Identities = 170/220 (77%), Positives = 186/220 (84%)
Query: 1 MTTMQGMEQAMPGAGPGVPQLGNMAVIHSHLWKGLQEKFLKGEPKVLGVVQILTALMSLS 60
MTTMQGMEQ PGAGP VPQLGN+ VIHS+L KGLQEKF K +PKVLGVV+IL ALMSLS
Sbjct: 24 MTTMQGMEQTTPGAGPDVPQLGNIDVIHSYLCKGLQEKFFKRKPKVLGVVRILIALMSLS 83
Query: 61 MGITMMCMASNTYGSNPISVYIGYTIWGSVMFIISGSLSIAAGIRTTKGLVRGSLGMNIT 120
MGI MMC+A ++Y +PI VY+ YTIWGSVMFIIS SLS+AAGIRTTKGLV GSLG NIT
Sbjct: 84 MGIIMMCVAFSSYEEHPIFVYVAYTIWGSVMFIISVSLSVAAGIRTTKGLVGGSLGKNIT 143
Query: 121 SSVLAASGILINTFSLAFYSFHHPYCNYYGNSNNCHGTMSILMGLDGMVLLLSVLEFCIA 180
SSVLA SGILIN SL FYSF + YCN+ S+NC+ TMSILMG DGMVLLLSVLEFCIA
Sbjct: 144 SSVLAISGILINAISLTFYSFRYHYCNHDQLSSNCYMTMSILMGTDGMVLLLSVLEFCIA 203
Query: 181 VSLSAFGCKVLCCTPGGVVLILPSHSHMAETASPTPLNEV 220
VSLSAFGCKVLCC+P VVLI PS+SHMAE ASPTPL V
Sbjct: 204 VSLSAFGCKVLCCSPSEVVLITPSNSHMAEIASPTPLKTV 243
>gi|239750062 PREDICTED: membrane-spanning 4-domains, subfamily A,
member 4E isoform 3 [Homo sapiens]
Length = 243
Score = 330 bits (845), Expect = 8e-91
Identities = 170/220 (77%), Positives = 186/220 (84%)
Query: 1 MTTMQGMEQAMPGAGPGVPQLGNMAVIHSHLWKGLQEKFLKGEPKVLGVVQILTALMSLS 60
MTTMQGMEQ PGAGP VPQLGN+ VIHS+L KGLQEKF K +PKVLGVV+IL ALMSLS
Sbjct: 24 MTTMQGMEQTTPGAGPDVPQLGNIDVIHSYLCKGLQEKFFKRKPKVLGVVRILIALMSLS 83
Query: 61 MGITMMCMASNTYGSNPISVYIGYTIWGSVMFIISGSLSIAAGIRTTKGLVRGSLGMNIT 120
MGI MMC+A ++Y +PI VY+ YTIWGSVMFIIS SLS+AAGIRTTKGLV GSLG NIT
Sbjct: 84 MGIIMMCVAFSSYEEHPIFVYVAYTIWGSVMFIISVSLSVAAGIRTTKGLVGGSLGKNIT 143
Query: 121 SSVLAASGILINTFSLAFYSFHHPYCNYYGNSNNCHGTMSILMGLDGMVLLLSVLEFCIA 180
SSVLA SGILIN SL FYSF + YCN+ S+NC+ TMSILMG DGMVLLLSVLEFCIA
Sbjct: 144 SSVLAISGILINAISLTFYSFRYHYCNHDQLSSNCYMTMSILMGTDGMVLLLSVLEFCIA 203
Query: 181 VSLSAFGCKVLCCTPGGVVLILPSHSHMAETASPTPLNEV 220
VSLSAFGCKVLCC+P VVLI PS+SHMAE ASPTPL V
Sbjct: 204 VSLSAFGCKVLCCSPSEVVLITPSNSHMAEIASPTPLKTV 243
>gi|239744375 PREDICTED: membrane-spanning 4-domains, subfamily A,
member 4E isoform 3 [Homo sapiens]
Length = 243
Score = 328 bits (842), Expect = 2e-90
Identities = 169/220 (76%), Positives = 186/220 (84%)
Query: 1 MTTMQGMEQAMPGAGPGVPQLGNMAVIHSHLWKGLQEKFLKGEPKVLGVVQILTALMSLS 60
MTTMQGMEQ PGAGP VPQLGN+ VIHS+L KGLQEKF K +PKVLGVV+IL ALMSLS
Sbjct: 24 MTTMQGMEQTTPGAGPDVPQLGNIDVIHSYLCKGLQEKFFKRKPKVLGVVRILIALMSLS 83
Query: 61 MGITMMCMASNTYGSNPISVYIGYTIWGSVMFIISGSLSIAAGIRTTKGLVRGSLGMNIT 120
MGI MMC+A ++Y +PI VY+ YTIWGSVMFIIS SLS+AAGIRTTKGLV GSLG NIT
Sbjct: 84 MGIIMMCVAFSSYEEHPIFVYVAYTIWGSVMFIISVSLSVAAGIRTTKGLVGGSLGKNIT 143
Query: 121 SSVLAASGILINTFSLAFYSFHHPYCNYYGNSNNCHGTMSILMGLDGMVLLLSVLEFCIA 180
SSVLA SGILIN SL FYSF + YCN+ S+NC+ TMSILMG DGMVLLLSVLEFCIA
Sbjct: 144 SSVLAISGILINAISLTFYSFRYHYCNHDQLSSNCYMTMSILMGTDGMVLLLSVLEFCIA 203
Query: 181 VSLSAFGCKVLCCTPGGVVLILPSHSHMAETASPTPLNEV 220
V+LSAFGCKVLCC+P VVLI PS+SHMAE ASPTPL V
Sbjct: 204 VALSAFGCKVLCCSPSEVVLITPSNSHMAEIASPTPLKTV 243
>gi|13899295 membrane-spanning 4-domains, subfamily A, member 8B
[Homo sapiens]
Length = 250
Score = 97.1 bits (240), Expect = 1e-20
Identities = 67/184 (36%), Positives = 102/184 (55%), Gaps = 13/184 (7%)
Query: 37 EKFLKGEPKVLGVVQILTALMSLSMGITMMCMASNTYGSNPISVYIGYTIWGSVMFIISG 96
+K LK E K LG +QI+ L + +G M + Y S IS Y G+ WG + FIISG
Sbjct: 63 QKALK-EGKTLGAIQIIIGLAHIGLGSIMATVLVGEYLS--ISFYGGFPFWGGLWFIISG 119
Query: 97 SLSIAAGIRT-TKGLVRGSLGMNITSSVLAASGILINTFSLAFYSFHHPYC--NYYGNSN 153
SLS+AA + + L+ GSLG+NI S++ +A G+++ L S HPY +YY +
Sbjct: 120 SLSVAAENQPYSYCLLSGSLGLNIVSAICSAVGVILFITDL---SIPHPYAYPDYYPYAW 176
Query: 154 NCHGTMSILMGLDGMVLLLSVLEFCIAVSLSAFGCKVLCCTPGGVVLILPSHSHMAETAS 213
+ M+I G++L+ +LEF IA + S FGC+++CC V +I P+ +
Sbjct: 177 GVNPGMAI----SGVLLVFCLLEFGIACASSHFGCQLVCCQSSNVSVIYPNIYAANPVIT 232
Query: 214 PTPL 217
P P+
Sbjct: 233 PEPV 236
>gi|73486649 membrane-spanning 4-domains, subfamily A, member 3
isoform a [Homo sapiens]
Length = 214
Score = 90.5 bits (223), Expect = 1e-18
Identities = 52/159 (32%), Positives = 86/159 (54%), Gaps = 4/159 (2%)
Query: 39 FLKGEPKVLGVVQILTALMSLSMGITMMCMASNTYGSNPI---SVYIGYTIWGSVMFIIS 95
+ K + +VLG +QIL A M L++G+ + + + + Y GY IWG+V F S
Sbjct: 43 YQKAKLQVLGAIQILNAAMILALGVFLGSLQYPYHFQKHFFFFTFYTGYPIWGAVFFCSS 102
Query: 96 GSLSIAAGIRTTKGLVRGSLGMNITSSVLAASGILINTFSLAFYSFHHPYCNYYGNSNN- 154
G+LS+ AGI+ T+ ++ S GMNI S+ +A G + ++A C+ S +
Sbjct: 103 GTLSVVAGIKPTRTWIQNSFGMNIASATIALVGTAFLSLNIAVNIQSLRSCHSSSESPDL 162
Query: 155 CHGTMSILMGLDGMVLLLSVLEFCIAVSLSAFGCKVLCC 193
C+ SI G+ ++L+L++LE C+ +S A C CC
Sbjct: 163 CNYMGSISNGMVSLLLILTLLELCVTISTIAMWCNANCC 201
>gi|8923206 membrane-spanning 4-domains, subfamily A, member 12
[Homo sapiens]
Length = 267
Score = 88.6 bits (218), Expect = 4e-18
Identities = 68/223 (30%), Positives = 112/223 (50%), Gaps = 28/223 (12%)
Query: 5 QGMEQAMPGA--GPGV-----PQLGNMAVIHSHLWKGLQEKFLKGEPKVLGVVQILTALM 57
QG ++A P PG+ P GN+ +I+ + + K E K LGV+QI+ LM
Sbjct: 44 QGAQRAQPYGITSPGIFASSQPGQGNIQMINPSVGTAVMN--FKEEAKALGVIQIMVGLM 101
Query: 58 SLSMGITMMCMASNTY----GSNPISVYIGYTIWGSVMFIISGSLSIAAGIRTTKGLVRG 113
+ GI ++C+ S ++ G +V GY WG + FIISGSLS++A ++ LV+G
Sbjct: 102 HIGFGI-VLCLISFSFREVLGFASTAVIGGYPFWGGLSFIISGSLSVSASKELSRCLVKG 160
Query: 114 SLGMNITSSVLAASGILINTFSLAFYSFHHPYCNYYGNSNNCHGTMSILMGLDGMVLLLS 173
SLGMNI SS+LA G+++ + G + + + G+ +++ S
Sbjct: 161 SLGMNIVSSILAFIGVILLLVDMCI----------NGVAGQDYWAVLSGKGISATLMIFS 210
Query: 174 VLEFCIAVSLSAFGCKVLCCTPGGVVLILPSHSHMAETASPTP 216
+LEF +A + + F + T V++I +M E+ TP
Sbjct: 211 LLEFFVACATAHFANQANTTTNMSVLVI----PNMYESNPVTP 249
>gi|149588599 membrane-spanning 4-domains, subfamily A, member 15
isoform 1 [Homo sapiens]
Length = 240
Score = 82.0 bits (201), Expect = 4e-16
Identities = 64/182 (35%), Positives = 87/182 (47%), Gaps = 25/182 (13%)
Query: 37 EKFLKGEPKVLGVVQILTALMSLSMGITMMCMASNTYGSNPISVYIGYTIWGSVMFIISG 96
E FL GEPKVLG VQIL L+ L G ++ + G + G WG FIISG
Sbjct: 64 ETFLTGEPKVLGTVQILIGLIHLGFGSVLLMVRRGHVGI--FFIEGGVPFWGGACFIISG 121
Query: 97 SLSIAAGIRTTKGLVRGSLGMNITSSVLAASG--ILINTFSLAFYSFHHPYCNYYGNSNN 154
SLS+AA T LVR SLG NI S + A +G IL+ F + N +
Sbjct: 122 SLSVAAEKNHTSCLVRSSLGTNILSVMAAFAGTAILLMDFGVT-------------NRDV 168
Query: 155 CHGTMSILMGLDGMVLLLSVLEFCIAVSLSAFGCKVLCCTPGGVVLILPSHSHMAETASP 214
G +++L + +VLEF AV FGC+ + V+ LP ++ A+ P
Sbjct: 169 DRGYLAVL-------TIFTVLEFFTAVIAMHFGCQAIHAQASAPVIFLP-NAFSADFNIP 220
Query: 215 TP 216
+P
Sbjct: 221 SP 222
>gi|23110997 membrane-spanning 4-domains, subfamily A, member 5
[Homo sapiens]
Length = 200
Score = 81.6 bits (200), Expect = 5e-16
Identities = 47/152 (30%), Positives = 77/152 (50%), Gaps = 2/152 (1%)
Query: 37 EKFLKGEPKVLGVVQILTALMSLSMGITMMCMASNTYGSNPISVYIGYTIWGSVMFIISG 96
+K + K+LG +QIL +M+ S G+ + Y P GY WGSV+FI SG
Sbjct: 40 QKLFARKMKILGTIQILFGIMTFSFGVIFLFTLLKPYPRFPFIFLSGYPFWGSVLFINSG 99
Query: 97 SLSIAAGIRTTKGLVRGSLGMNITSSVLAASGILINTFSLAFYSFHHPYCNYYGNSNNCH 156
+ IA +TT+ L+ S MN S++ A +GI++ TF F + C Y ++ C
Sbjct: 100 AFLIAVKRKTTETLIILSRIMNFLSALGAIAGIILLTF--GFILDQNYICGYSHQNSQCK 157
Query: 157 GTMSILMGLDGMVLLLSVLEFCIAVSLSAFGC 188
+ +G+ ++ S++E I++ S GC
Sbjct: 158 AVTVLFLGILITLMTFSIIELFISLPFSILGC 189
>gi|23110987 membrane-spanning 4-domains, subfamily A, member 1
[Homo sapiens]
Length = 297
Score = 77.8 bits (190), Expect = 7e-15
Identities = 62/236 (26%), Positives = 100/236 (42%), Gaps = 30/236 (12%)
Query: 3 TMQGMEQAMPGAGPGVPQLGNMAVIHS-HLWKGLQEKFLKGEPKVLGVVQILTALMSLSM 61
++ G A P GP Q G + G + F E K LG VQI+ L +++
Sbjct: 7 SVNGTFPAEPMKGPIAMQSGPKPLFRRMSSLVGPTQSFFMRESKTLGAVQIMNGLFHIAL 66
Query: 62 GITMMCMASNTYGSNPISVYIGYTIWGSVMFIISGSLSIAAGIRTTKGLVRGSLGMNITS 121
G +M A Y PI V + Y +WG +M+IISGSL A + K LV+G + MN S
Sbjct: 67 GGLLMIPAG-IYA--PICVTVWYPLWGGIMYIISGSLLAATEKNSRKCLVKGKMIMNSLS 123
Query: 122 SVLAASGILINTF--------------SLAFYSFHHPYCNYYG------------NSNNC 155
A SG++++ SL F H PY N Y ++ C
Sbjct: 124 LFAAISGMILSIMDILNIKISHFLKMESLNFIRAHTPYINIYNCEPANPSEKNSPSTQYC 183
Query: 156 HGTMSILMGLDGMVLLLSVLEFCIAVSLSAFGCKVLCCTPGGVVLILPSHSHMAET 211
+ S+ +G+ ++L+ + + + + K C P +++L + +T
Sbjct: 184 YSIQSLFLGILSVMLIFAFFQELVIAGIVENEWKRTCSRPKSNIVLLSAEEKKEQT 239
>gi|23110989 membrane-spanning 4-domains, subfamily A, member 1
[Homo sapiens]
Length = 297
Score = 77.8 bits (190), Expect = 7e-15
Identities = 62/236 (26%), Positives = 100/236 (42%), Gaps = 30/236 (12%)
Query: 3 TMQGMEQAMPGAGPGVPQLGNMAVIHS-HLWKGLQEKFLKGEPKVLGVVQILTALMSLSM 61
++ G A P GP Q G + G + F E K LG VQI+ L +++
Sbjct: 7 SVNGTFPAEPMKGPIAMQSGPKPLFRRMSSLVGPTQSFFMRESKTLGAVQIMNGLFHIAL 66
Query: 62 GITMMCMASNTYGSNPISVYIGYTIWGSVMFIISGSLSIAAGIRTTKGLVRGSLGMNITS 121
G +M A Y PI V + Y +WG +M+IISGSL A + K LV+G + MN S
Sbjct: 67 GGLLMIPAG-IYA--PICVTVWYPLWGGIMYIISGSLLAATEKNSRKCLVKGKMIMNSLS 123
Query: 122 SVLAASGILINTF--------------SLAFYSFHHPYCNYYG------------NSNNC 155
A SG++++ SL F H PY N Y ++ C
Sbjct: 124 LFAAISGMILSIMDILNIKISHFLKMESLNFIRAHTPYINIYNCEPANPSEKNSPSTQYC 183
Query: 156 HGTMSILMGLDGMVLLLSVLEFCIAVSLSAFGCKVLCCTPGGVVLILPSHSHMAET 211
+ S+ +G+ ++L+ + + + + K C P +++L + +T
Sbjct: 184 YSIQSLFLGILSVMLIFAFFQELVIAGIVENEWKRTCSRPKSNIVLLSAEEKKEQT 239
>gi|4503677 membrane-spanning 4-domains, subfamily A, member 2
isoform 1 [Homo sapiens]
Length = 244
Score = 72.4 bits (176), Expect = 3e-13
Identities = 58/155 (37%), Positives = 79/155 (50%), Gaps = 12/155 (7%)
Query: 40 LKGEPKVLGVVQILTALMSLSMGITMMCMA---SNTYGSNPISVYIGYTIWGSVMFIISG 96
LK E + LGV QILTA++ L G T++C S+ G S GY WG++ F ISG
Sbjct: 54 LKKEQEFLGVTQILTAMICLCFG-TVVCSVLDISHIEGDIFSSFKAGYPFWGAIFFSISG 112
Query: 97 SLSIAAGIRTTKGLVRGSLGMNITSSVLAASGILINTF----SLAFYSFHHPYCNYYGNS 152
LSI + R LVRGSLG N SS+ +GI I SLA+ H C + +
Sbjct: 113 MLSIISERRNATYLVRGSLGANTASSIAGGTGITILIINLKKSLAYIHIHS--CQKFFET 170
Query: 153 NNCHGTMSILMGLDGMVLLLSVLEFCIAVSLSAFG 187
+ S + + M+L L++L AVSL+ G
Sbjct: 171 KCFMASFSTEIVV--MMLFLTILGLGSAVSLTICG 203
>gi|23238238 membrane-spanning 4-domains, subfamily A, member 6A
isoform 1 [Homo sapiens]
Length = 248
Score = 71.6 bits (174), Expect = 5e-13
Identities = 61/194 (31%), Positives = 92/194 (47%), Gaps = 20/194 (10%)
Query: 37 EKFLKGEPKVLGVVQILTALMSLSMGITMMCMASNTYGSNPISVYIG--YTIWGSVMFII 94
+K L E KV+G +QIL +M LS+GI + + + + S + Y G FII
Sbjct: 38 KKHLHAEIKVIGTIQILCGMMVLSLGIILASASFSPNFTQVTSTLLNSAYPFIGPFFFII 97
Query: 95 SGSLSIAAGIRTTKGLVRGSLGMNITSSVLAASGILINTFSLAFYSFHHPYCN------- 147
SGSLSIA R TK LV SL +I S++ A G +I + A + C
Sbjct: 98 SGSLSIATEKRLTKLLVHSSLVGSILSALSALVGFIILSVKQATLNPASLQCELDKNNIP 157
Query: 148 -------YYGNS---NNCHGTMSILMGLDGMVLLLSVLEFCIAVSLSAFGCKVLCCTPGG 197
+Y +S +C+ + L G ++L+ ++LEFC+AV + K G
Sbjct: 158 TRSYVSYFYHDSLYTTDCYTAKASLAGTLSLMLICTLLEFCLAVLTAVLRWKQAYSDFPG 217
Query: 198 VVLILPSHSHMAET 211
VL LP HS++ +
Sbjct: 218 SVLFLP-HSYIGNS 230
>gi|119226217 membrane-spanning 4-domains, subfamily A, member 14
isoform 1 [Homo sapiens]
Length = 679
Score = 71.2 bits (173), Expect = 6e-13
Identities = 41/108 (37%), Positives = 61/108 (56%), Gaps = 5/108 (4%)
Query: 39 FLKGEPKVLGVVQILTALMSLSMGITMMCMASNTYGSNPISVYIGYTIWGSVMFIISGSL 98
FLKGEP+VLG QIL AL+ + G P+ V GY WG+++FI++G L
Sbjct: 37 FLKGEPRVLGATQILLALIIVGFGTIFALNYIGFSQRLPLVVLTGYPFWGALIFILTGYL 96
Query: 99 SIAAGIRTTKGLVRGSLGMNITSSVLAASGILINTFSLAFYSFHHPYC 146
++ + +K L +G GMN+ SS++A +GI TF++ Y YC
Sbjct: 97 TVTD--KKSKLLGQGVTGMNVISSLVAITGI---TFTILSYRHQDKYC 139
>gi|214831008 membrane-spanning 4-domains, subfamily A, member 2
isoform 2 [Homo sapiens]
Length = 195
Score = 68.9 bits (167), Expect = 3e-12
Identities = 47/110 (42%), Positives = 59/110 (53%), Gaps = 8/110 (7%)
Query: 40 LKGEPKVLGVVQILTALMSLSMGITMMCMA---SNTYGSNPISVYIGYTIWGSVMFIISG 96
LK E + LGV QILTA++ L G T++C S+ G S GY WG++ F ISG
Sbjct: 54 LKKEQEFLGVTQILTAMICLCFG-TVVCSVLDISHIEGDIFSSFKAGYPFWGAIFFSISG 112
Query: 97 SLSIAAGIRTTKGLVRGSLGMNITSSVLAASGILINTF----SLAFYSFH 142
LSI + R LVRGSLG N SS+ +GI I SLA+ H
Sbjct: 113 MLSIISERRNATYLVRGSLGANTASSIAGGTGITILIINLKKSLAYIHIH 162
>gi|169202868 PREDICTED: similar to membrane-spanning 4-domains,
subfamily A, member 8B [Homo sapiens]
Length = 391
Score = 67.8 bits (164), Expect = 7e-12
Identities = 55/206 (26%), Positives = 98/206 (47%), Gaps = 22/206 (10%)
Query: 17 GVPQLGNMAVIHSHLWKGLQEKFLKGEPKV-LGVVQILTALMSLSMGITMMCMASNT--Y 73
G L N+ V++ + G+Q + + + + +G + TA+ L +G+T + A N Y
Sbjct: 112 GRANLQNLLVVNQNSAAGVQSQPIGYQRQYPVGTASLQTAIQIL-IGLTHIFSAINPVLY 170
Query: 74 GSNPISVYIGYTIWGSVMFIISGSLSIAAGIRTTKGLVRGSLGMNITSSVLAASGILINT 133
++ GY +WG + +I+SGSLS+ A + +V S+ NI S++ A +GI I
Sbjct: 171 YYPFVTWLSGYPLWGGLSYIVSGSLSVWAAKDPSPCVVNSSISFNIISALFAFAGIFIII 230
Query: 134 FSLAFYSFHHPYCNYYGNSNNCHGTMSILMGLDGMVLLLSVLEFCIAVSLSAFGCKVLCC 193
L+ Y Y Y + + G +L ++LEF + +S FGC+ CC
Sbjct: 231 TDLSLY-----YVTTYSKA------------VSGGLLPFALLEFILTCVVSHFGCQATCC 273
Query: 194 TPGGVVLILPS-HSHMAETASPTPLN 218
V ++P+ S + +P+N
Sbjct: 274 RQFENVAVIPTVFSFNPANTTTSPVN 299
>gi|169203526 PREDICTED: similar to membrane-spanning 4-domains,
subfamily A, member 8B [Homo sapiens]
Length = 391
Score = 67.8 bits (164), Expect = 7e-12
Identities = 55/206 (26%), Positives = 98/206 (47%), Gaps = 22/206 (10%)
Query: 17 GVPQLGNMAVIHSHLWKGLQEKFLKGEPKV-LGVVQILTALMSLSMGITMMCMASNT--Y 73
G L N+ V++ + G+Q + + + + +G + TA+ L +G+T + A N Y
Sbjct: 112 GRANLQNLLVVNQNSAAGVQSQPIGYQRQYPVGTASLQTAIQIL-IGLTHIFSAINPVLY 170
Query: 74 GSNPISVYIGYTIWGSVMFIISGSLSIAAGIRTTKGLVRGSLGMNITSSVLAASGILINT 133
++ GY +WG + +I+SGSLS+ A + +V S+ NI S++ A +GI I
Sbjct: 171 YYPFVTWLSGYPLWGGLSYIVSGSLSVWAAKDPSPCVVNSSISFNIISALFAFAGIFIII 230
Query: 134 FSLAFYSFHHPYCNYYGNSNNCHGTMSILMGLDGMVLLLSVLEFCIAVSLSAFGCKVLCC 193
L+ Y Y Y + + G +L ++LEF + +S FGC+ CC
Sbjct: 231 TDLSLY-----YVTTYSKA------------VSGGLLPFALLEFILTCVVSHFGCQATCC 273
Query: 194 TPGGVVLILPS-HSHMAETASPTPLN 218
V ++P+ S + +P+N
Sbjct: 274 RQFENVAVIPTVFSFNPANTTTSPVN 299
>gi|169202217 PREDICTED: similar to membrane-spanning 4-domains,
subfamily A, member 8B [Homo sapiens]
Length = 391
Score = 67.8 bits (164), Expect = 7e-12
Identities = 55/206 (26%), Positives = 98/206 (47%), Gaps = 22/206 (10%)
Query: 17 GVPQLGNMAVIHSHLWKGLQEKFLKGEPKV-LGVVQILTALMSLSMGITMMCMASNT--Y 73
G L N+ V++ + G+Q + + + + +G + TA+ L +G+T + A N Y
Sbjct: 112 GRANLQNLLVVNQNSAAGVQSQPIGYQRQYPVGTASLQTAIQIL-IGLTHIFSAINPVLY 170
Query: 74 GSNPISVYIGYTIWGSVMFIISGSLSIAAGIRTTKGLVRGSLGMNITSSVLAASGILINT 133
++ GY +WG + +I+SGSLS+ A + +V S+ NI S++ A +GI I
Sbjct: 171 YYPFVTWLSGYPLWGGLSYIVSGSLSVWAAKDPSPCVVNSSISFNIISALFAFAGIFIII 230
Query: 134 FSLAFYSFHHPYCNYYGNSNNCHGTMSILMGLDGMVLLLSVLEFCIAVSLSAFGCKVLCC 193
L+ Y Y Y + + G +L ++LEF + +S FGC+ CC
Sbjct: 231 TDLSLY-----YVTTYSKA------------VSGGLLPFALLEFILTCVVSHFGCQATCC 273
Query: 194 TPGGVVLILPS-HSHMAETASPTPLN 218
V ++P+ S + +P+N
Sbjct: 274 RQFENVAVIPTVFSFNPANTTTSPVN 299
>gi|23238234 membrane-spanning 4-domains, subfamily A, member 6A
isoform 2 [Homo sapiens]
Length = 225
Score = 66.6 bits (161), Expect = 2e-11
Identities = 53/164 (32%), Positives = 80/164 (48%), Gaps = 19/164 (11%)
Query: 37 EKFLKGEPKVLGVVQILTALMSLSMGITMMCMASNTYGSNPISVYIG--YTIWGSVMFII 94
+K L E KV+G +QIL +M LS+GI + + + + S + Y G FII
Sbjct: 38 KKHLHAEIKVIGTIQILCGMMVLSLGIILASASFSPNFTQVTSTLLNSAYPFIGPFFFII 97
Query: 95 SGSLSIAAGIRTTKGLVRGSLGMNITSSVLAASGILINTFSLAFYSFHHPYCN------- 147
SGSLSIA R TK LV SL +I S++ A G +I + A + C
Sbjct: 98 SGSLSIATEKRLTKLLVHSSLVGSILSALSALVGFIILSVKQATLNPASLQCELDKNNIP 157
Query: 148 -------YYGNS---NNCHGTMSILMGLDGMVLLLSVLEFCIAV 181
+Y +S +C+ + L G ++L+ ++LEFC+AV
Sbjct: 158 TRSYVSYFYHDSLYTTDCYTAKASLAGTLSLMLICTLLEFCLAV 201
>gi|11139299 membrane-spanning 4-domains, subfamily A, member 7
isoform 1 [Homo sapiens]
Length = 240
Score = 63.9 bits (154), Expect = 1e-10
Identities = 66/227 (29%), Positives = 98/227 (43%), Gaps = 27/227 (11%)
Query: 6 GMEQAMPGAGPGVPQL---GNMAVIHSHLWKGLQEKFLKGEPKVLGVVQILTALMSLSMG 62
G+ + G +PQ G+M +L GL E VLG VQIL L+ S+G
Sbjct: 9 GVSHSFTPKGITIPQREKPGHMYQNEDYLQNGLPT-----ETTVLGTVQILCCLLISSLG 63
Query: 63 ITMMCMASNTYGSNPISVYI--GYTIWGSVMFIISGSLSIAAGIRTTKGLVRGSLGMNIT 120
++ ++ + IS + GY G++ F I+GSLSI +G ++TK SL N
Sbjct: 64 AILVFAPYPSHFNPAISTTLMSGYPFLGALCFGITGSLSIISGKQSTKPFDLSSLTSNAV 123
Query: 121 SSVLAASGILINTFSLAF-------------YSFHHPYCNYY---GNSNNCHGTMSILMG 164
SSV A +G+ + S+ Y PY YY +C T L G
Sbjct: 124 SSVTAGAGLFLLADSMVALRTASQHCGSEMDYLSSLPYSEYYYPIYEIKDCLLTSVSLTG 183
Query: 165 LDGMVLLLSVLEFCIAVSLSAFGCKVLCC-TPGGVVLILPSHSHMAE 210
+ ++L+ +VLE +A S F K L PG S H+ +
Sbjct: 184 VLVVMLIFTVLELLLAAYSSVFWWKQLYSNNPGSSFSSTQSQDHIQQ 230
>gi|46249357 membrane-spanning 4-domains, subfamily A, member 7
isoform 1 [Homo sapiens]
Length = 240
Score = 63.9 bits (154), Expect = 1e-10
Identities = 66/227 (29%), Positives = 98/227 (43%), Gaps = 27/227 (11%)
Query: 6 GMEQAMPGAGPGVPQL---GNMAVIHSHLWKGLQEKFLKGEPKVLGVVQILTALMSLSMG 62
G+ + G +PQ G+M +L GL E VLG VQIL L+ S+G
Sbjct: 9 GVSHSFTPKGITIPQREKPGHMYQNEDYLQNGLPT-----ETTVLGTVQILCCLLISSLG 63
Query: 63 ITMMCMASNTYGSNPISVYI--GYTIWGSVMFIISGSLSIAAGIRTTKGLVRGSLGMNIT 120
++ ++ + IS + GY G++ F I+GSLSI +G ++TK SL N
Sbjct: 64 AILVFAPYPSHFNPAISTTLMSGYPFLGALCFGITGSLSIISGKQSTKPFDLSSLTSNAV 123
Query: 121 SSVLAASGILINTFSLAF-------------YSFHHPYCNYY---GNSNNCHGTMSILMG 164
SSV A +G+ + S+ Y PY YY +C T L G
Sbjct: 124 SSVTAGAGLFLLADSMVALRTASQHCGSEMDYLSSLPYSEYYYPIYEIKDCLLTSVSLTG 183
Query: 165 LDGMVLLLSVLEFCIAVSLSAFGCKVLCC-TPGGVVLILPSHSHMAE 210
+ ++L+ +VLE +A S F K L PG S H+ +
Sbjct: 184 VLVVMLIFTVLELLLAAYSSVFWWKQLYSNNPGSSFSSTQSQDHIQQ 230
>gi|73486653 membrane-spanning 4-domains, subfamily A, member 3
isoform b [Homo sapiens]
Length = 168
Score = 61.6 bits (148), Expect = 5e-10
Identities = 34/103 (33%), Positives = 56/103 (54%), Gaps = 1/103 (0%)
Query: 92 FIISGSLSIAAGIRTTKGLVRGSLGMNITSSVLAASGILINTFSLAFYSFHHPYCNYYGN 151
F SG+LS+ AGI+ T+ ++ S GMNI S+ +A G + ++A C+
Sbjct: 53 FCSSGTLSVVAGIKPTRTWIQNSFGMNIASATIALVGTAFLSLNIAVNIQSLRSCHSSSE 112
Query: 152 SNN-CHGTMSILMGLDGMVLLLSVLEFCIAVSLSAFGCKVLCC 193
S + C+ SI G+ ++L+L++LE C+ +S A C CC
Sbjct: 113 SPDLCNYMGSISNGMVSLLLILTLLELCVTISTIAMWCNANCC 155
>gi|22749421 membrane-spanning 4-domains, subfamily A, member 15
isoform 2 [Homo sapiens]
Length = 147
Score = 57.8 bits (138), Expect = 7e-09
Identities = 46/136 (33%), Positives = 64/136 (47%), Gaps = 23/136 (16%)
Query: 83 GYTIWGSVMFIISGSLSIAAGIRTTKGLVRGSLGMNITSSVLAASG--ILINTFSLAFYS 140
G WG FIISGSLS+AA T LVR SLG NI S + A +G IL+ F +
Sbjct: 15 GVPFWGGACFIISGSLSVAAEKNHTSCLVRSSLGTNILSVMAAFAGTAILLMDFGVT--- 71
Query: 141 FHHPYCNYYGNSNNCHGTMSILMGLDGMVLLLSVLEFCIAVSLSAFGCKVLCCTPGGVVL 200
N + G +++L + +VLEF AV FGC+ + V+
Sbjct: 72 ----------NRDVDRGYLAVL-------TIFTVLEFFTAVIAMHFGCQAIHAQASAPVI 114
Query: 201 ILPSHSHMAETASPTP 216
LP ++ A+ P+P
Sbjct: 115 FLP-NAFSADFNIPSP 129
>gi|23238236 membrane-spanning 4-domains, subfamily A, member 6A
isoform 3 [Homo sapiens]
Length = 178
Score = 57.0 bits (136), Expect = 1e-08
Identities = 39/97 (40%), Positives = 53/97 (54%), Gaps = 2/97 (2%)
Query: 37 EKFLKGEPKVLGVVQILTALMSLSMGITMMCMASNTYGSNPISVYIG--YTIWGSVMFII 94
+K L E KV+G +QIL +M LS+GI + + + + S + Y G FII
Sbjct: 38 KKHLHAEIKVIGTIQILCGMMVLSLGIILASASFSPNFTQVTSTLLNSAYPFIGPFFFII 97
Query: 95 SGSLSIAAGIRTTKGLVRGSLGMNITSSVLAASGILI 131
SGSLSIA R TK LV SL +I S++ A G +I
Sbjct: 98 SGSLSIATEKRLTKLLVHSSLVGSILSALSALVGFII 134
>gi|119226220 membrane-spanning 4-domains, subfamily A, member 14
isoform 2 [Homo sapiens]
Length = 662
Score = 53.5 bits (127), Expect = 1e-07
Identities = 35/108 (32%), Positives = 49/108 (45%), Gaps = 22/108 (20%)
Query: 39 FLKGEPKVLGVVQILTALMSLSMGITMMCMASNTYGSNPISVYIGYTIWGSVMFIISGSL 98
FLKGEP+VLG QIL AL+ + G P+ V GY WG++
Sbjct: 37 FLKGEPRVLGATQILLALIIVGFGTIFALNYIGFSQRLPLVVLTGYPFWGAL-------- 88
Query: 99 SIAAGIRTTKGLVRGSLGMNITSSVLAASGILINTFSLAFYSFHHPYC 146
+ +G GMN+ SS++A +GI TF++ Y YC
Sbjct: 89 -----------IGQGVTGMNVISSLVAITGI---TFTILSYRHQDKYC 122
>gi|46249347 membrane-spanning 4-domains, subfamily A, member 7
isoform 2 [Homo sapiens]
Length = 195
Score = 42.7 bits (99), Expect = 2e-04
Identities = 41/136 (30%), Positives = 58/136 (42%), Gaps = 17/136 (12%)
Query: 92 FIISGSLSIAAGIRTTKGLVRGSLGMNITSSVLAASGILINTFSLAF------------- 138
F I+GSLSI +G ++TK SL N SSV A +G+ + S+
Sbjct: 50 FGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQHCGSEMD 109
Query: 139 YSFHHPYCNYY---GNSNNCHGTMSILMGLDGMVLLLSVLEFCIAVSLSAFGCKVLCC-T 194
Y PY YY +C T L G+ ++L+ +VLE +A S F K L
Sbjct: 110 YLSSLPYSEYYYPIYEIKDCLLTSVSLTGVLVVMLIFTVLELLLAAYSSVFWWKQLYSNN 169
Query: 195 PGGVVLILPSHSHMAE 210
PG S H+ +
Sbjct: 170 PGSSFSSTQSQDHIQQ 185
>gi|46249359 membrane-spanning 4-domains, subfamily A, member 7
isoform 2 [Homo sapiens]
Length = 195
Score = 42.7 bits (99), Expect = 2e-04
Identities = 41/136 (30%), Positives = 58/136 (42%), Gaps = 17/136 (12%)
Query: 92 FIISGSLSIAAGIRTTKGLVRGSLGMNITSSVLAASGILINTFSLAF------------- 138
F I+GSLSI +G ++TK SL N SSV A +G+ + S+
Sbjct: 50 FGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQHCGSEMD 109
Query: 139 YSFHHPYCNYY---GNSNNCHGTMSILMGLDGMVLLLSVLEFCIAVSLSAFGCKVLCC-T 194
Y PY YY +C T L G+ ++L+ +VLE +A S F K L
Sbjct: 110 YLSSLPYSEYYYPIYEIKDCLLTSVSLTGVLVVMLIFTVLELLLAAYSSVFWWKQLYSNN 169
Query: 195 PGGVVLILPSHSHMAE 210
PG S H+ +
Sbjct: 170 PGSSFSSTQSQDHIQQ 185
>gi|73486651 membrane-spanning 4-domains, subfamily A, member 3
isoform c [Homo sapiens]
Length = 91
Score = 39.7 bits (91), Expect = 0.002
Identities = 23/78 (29%), Positives = 39/78 (50%), Gaps = 1/78 (1%)
Query: 117 MNITSSVLAASGILINTFSLAFYSFHHPYCNYYGNSNN-CHGTMSILMGLDGMVLLLSVL 175
MNI S+ +A G + ++A C+ S + C+ SI G+ ++L+L++L
Sbjct: 1 MNIASATIALVGTAFLSLNIAVNIQSLRSCHSSSESPDLCNYMGSISNGMVSLLLILTLL 60
Query: 176 EFCIAVSLSAFGCKVLCC 193
E C+ +S A C CC
Sbjct: 61 ELCVTISTIAMWCNANCC 78
>gi|167466260 membrane-spanning 4-domains, subfamily A, member 10
[Homo sapiens]
Length = 267
Score = 35.8 bits (81), Expect = 0.029
Identities = 38/138 (27%), Positives = 57/138 (41%), Gaps = 10/138 (7%)
Query: 45 KVLGVVQILTALMSLSMGITMMCMASNTYGSNPISVYIGYTIWGSVMFIISGSLSIAAGI 104
K LG I AL+ L G + + N + + + Y WG+ F+ISG L+I
Sbjct: 58 KELGAFHITIALLHLVFGGYLASIVKNLH---LVVLKSWYPFWGAASFLISGILAITMKT 114
Query: 105 RTTKGLVRGSLGMNITSSVLAASGILINTFSLAFYS-FHHPYCNYYGNSNNCHGTMSILM 163
+ L L N+ S SG+ + + L S F P Y NS H +
Sbjct: 115 FSKTYLKMLCLMTNLISLFCVLSGLFVISKDLFLESPFESPIWRMYPNS-TVH-----IQ 168
Query: 164 GLDGMVLLLSVLEFCIAV 181
L+ +L +VLE + V
Sbjct: 169 RLELALLCFTVLELFLPV 186
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.136 0.414
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 8,123,951
Number of Sequences: 37866
Number of extensions: 312907
Number of successful extensions: 870
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 33
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 812
Number of HSP's gapped (non-prelim): 37
length of query: 220
length of database: 18,247,518
effective HSP length: 98
effective length of query: 122
effective length of database: 14,536,650
effective search space: 1773471300
effective search space used: 1773471300
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.