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Search of human proteins with 19924131
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|19924131 RAD50 homolog isoform 2 [Homo sapiens]
(1173 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|19924131 RAD50 homolog isoform 2 [Homo sapiens] 2280 0.0
gi|19924129 RAD50 homolog isoform 1 [Homo sapiens] 2280 0.0
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 149 1e-35
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 149 1e-35
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 147 8e-35
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 144 4e-34
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 144 5e-34
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 144 6e-34
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 143 8e-34
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 143 1e-33
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 143 1e-33
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 138 4e-32
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 137 8e-32
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 136 1e-31
gi|71061468 centromere protein E [Homo sapiens] 135 2e-31
gi|21735548 centrosomal protein 2 [Homo sapiens] 134 4e-31
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 134 4e-31
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 134 7e-31
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 133 1e-30
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 132 2e-30
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 132 3e-30
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 132 3e-30
gi|58530840 desmoplakin isoform I [Homo sapiens] 131 4e-30
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 130 7e-30
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 129 2e-29
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 129 2e-29
gi|28416946 myosin 18A isoform a [Homo sapiens] 129 2e-29
gi|156104908 myosin heavy chain 6 [Homo sapiens] 128 3e-29
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 127 5e-29
gi|46049114 M-phase phosphoprotein 1 [Homo sapiens] 127 8e-29
>gi|19924131 RAD50 homolog isoform 2 [Homo sapiens]
Length = 1173
Score = 2280 bits (5908), Expect = 0.0
Identities = 1173/1173 (100%), Positives = 1173/1173 (100%)
Query: 1 MISSLGVSKAVLNNVIFCHQEDSNWPLSEGKALKQKFDEIFSATRYIKALETLRQVRQTQ 60
MISSLGVSKAVLNNVIFCHQEDSNWPLSEGKALKQKFDEIFSATRYIKALETLRQVRQTQ
Sbjct: 1 MISSLGVSKAVLNNVIFCHQEDSNWPLSEGKALKQKFDEIFSATRYIKALETLRQVRQTQ 60
Query: 61 GQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIE 120
GQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIE
Sbjct: 61 GQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIE 120
Query: 121 HNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKE 180
HNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKE
Sbjct: 121 HNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKE 180
Query: 181 RKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLE 240
RKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLE
Sbjct: 181 RKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLE 240
Query: 241 LDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGL 300
LDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGL
Sbjct: 241 LDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGL 300
Query: 301 GRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVET 360
GRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVET
Sbjct: 301 GRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVET 360
Query: 361 LKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRH 420
LKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRH
Sbjct: 361 LKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRH 420
Query: 421 SDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKE 480
SDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKE
Sbjct: 421 SDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKE 480
Query: 481 EQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQS 540
EQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQS
Sbjct: 481 EQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQS 540
Query: 541 CCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSI 600
CCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSI
Sbjct: 541 CCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSI 600
Query: 601 IDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQ 660
IDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQ
Sbjct: 601 IDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQ 660
Query: 661 MELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQ 720
MELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQ
Sbjct: 661 MELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQ 720
Query: 721 IQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTL 780
IQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTL
Sbjct: 721 IQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTL 780
Query: 781 EKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETE 840
EKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETE
Sbjct: 781 EKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETE 840
Query: 841 LNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERK 900
LNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERK
Sbjct: 841 LNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERK 900
Query: 901 QHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRD 960
QHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRD
Sbjct: 901 QHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRD 960
Query: 961 AEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQD 1020
AEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQD
Sbjct: 961 AEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQD 1020
Query: 1021 IEYIEIRSDADENVSASDKRRNYNYRVVMLKGDTALDMRGRCSAGQKVLASLIIRLALAE 1080
IEYIEIRSDADENVSASDKRRNYNYRVVMLKGDTALDMRGRCSAGQKVLASLIIRLALAE
Sbjct: 1021 IEYIEIRSDADENVSASDKRRNYNYRVVMLKGDTALDMRGRCSAGQKVLASLIIRLALAE 1080
Query: 1081 TFCLNCGIIALDEPTTNLDRENIESLAHALVEIIKSRSQQRNFQLLVITHDEDFVELLGR 1140
TFCLNCGIIALDEPTTNLDRENIESLAHALVEIIKSRSQQRNFQLLVITHDEDFVELLGR
Sbjct: 1081 TFCLNCGIIALDEPTTNLDRENIESLAHALVEIIKSRSQQRNFQLLVITHDEDFVELLGR 1140
Query: 1141 SEYVEKFYRIKKNIDQCSEIVKCSVSSLGFNVH 1173
SEYVEKFYRIKKNIDQCSEIVKCSVSSLGFNVH
Sbjct: 1141 SEYVEKFYRIKKNIDQCSEIVKCSVSSLGFNVH 1173
>gi|19924129 RAD50 homolog isoform 1 [Homo sapiens]
Length = 1312
Score = 2280 bits (5908), Expect = 0.0
Identities = 1173/1173 (100%), Positives = 1173/1173 (100%)
Query: 1 MISSLGVSKAVLNNVIFCHQEDSNWPLSEGKALKQKFDEIFSATRYIKALETLRQVRQTQ 60
MISSLGVSKAVLNNVIFCHQEDSNWPLSEGKALKQKFDEIFSATRYIKALETLRQVRQTQ
Sbjct: 140 MISSLGVSKAVLNNVIFCHQEDSNWPLSEGKALKQKFDEIFSATRYIKALETLRQVRQTQ 199
Query: 61 GQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIE 120
GQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIE
Sbjct: 200 GQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIE 259
Query: 121 HNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKE 180
HNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKE
Sbjct: 260 HNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKE 319
Query: 181 RKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLE 240
RKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLE
Sbjct: 320 RKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLE 379
Query: 241 LDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGL 300
LDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGL
Sbjct: 380 LDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGL 439
Query: 301 GRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVET 360
GRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVET
Sbjct: 440 GRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVET 499
Query: 361 LKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRH 420
LKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRH
Sbjct: 500 LKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRH 559
Query: 421 SDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKE 480
SDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKE
Sbjct: 560 SDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKE 619
Query: 481 EQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQS 540
EQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQS
Sbjct: 620 EQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQS 679
Query: 541 CCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSI 600
CCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSI
Sbjct: 680 CCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSI 739
Query: 601 IDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQ 660
IDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQ
Sbjct: 740 IDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQ 799
Query: 661 MELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQ 720
MELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQ
Sbjct: 800 MELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQ 859
Query: 721 IQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTL 780
IQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTL
Sbjct: 860 IQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTL 919
Query: 781 EKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETE 840
EKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETE
Sbjct: 920 EKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETE 979
Query: 841 LNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERK 900
LNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERK
Sbjct: 980 LNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERK 1039
Query: 901 QHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRD 960
QHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRD
Sbjct: 1040 QHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRD 1099
Query: 961 AEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQD 1020
AEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQD
Sbjct: 1100 AEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQD 1159
Query: 1021 IEYIEIRSDADENVSASDKRRNYNYRVVMLKGDTALDMRGRCSAGQKVLASLIIRLALAE 1080
IEYIEIRSDADENVSASDKRRNYNYRVVMLKGDTALDMRGRCSAGQKVLASLIIRLALAE
Sbjct: 1160 IEYIEIRSDADENVSASDKRRNYNYRVVMLKGDTALDMRGRCSAGQKVLASLIIRLALAE 1219
Query: 1081 TFCLNCGIIALDEPTTNLDRENIESLAHALVEIIKSRSQQRNFQLLVITHDEDFVELLGR 1140
TFCLNCGIIALDEPTTNLDRENIESLAHALVEIIKSRSQQRNFQLLVITHDEDFVELLGR
Sbjct: 1220 TFCLNCGIIALDEPTTNLDRENIESLAHALVEIIKSRSQQRNFQLLVITHDEDFVELLGR 1279
Query: 1141 SEYVEKFYRIKKNIDQCSEIVKCSVSSLGFNVH 1173
SEYVEKFYRIKKNIDQCSEIVKCSVSSLGFNVH
Sbjct: 1280 SEYVEKFYRIKKNIDQCSEIVKCSVSSLGFNVH 1312
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 149 bits (377), Expect = 1e-35
Identities = 187/882 (21%), Positives = 389/882 (44%), Gaps = 119/882 (13%)
Query: 48 KALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYEN 107
K E L+ ++ + LK +++ + ++++ + S+ A +++ +
Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1153
Query: 108 ELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLND 167
EL+ LK L++ LD+ + R K+ E++ + L++ +++ + + Q+ +
Sbjct: 1154 ELEALKTELEDT---------LDSTATQQELRAKR-EQEVTVLKKALDEETRSHEAQVQE 1203
Query: 168 LYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRA 227
+ H + V E +L R L+K + L +E ++L E R+ QA + EH +
Sbjct: 1204 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL-RVLGQAKQEVEHKKK 1262
Query: 228 R-DSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLK 286
+ ++ +Q L ++ R +++ HKL + E ++ ++N+ K
Sbjct: 1263 KLEAQVQELQSKCSDGERARAELNDK----VHKL-----QNEVESVTGMLNEAEGKAIKL 1313
Query: 287 QKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAE 346
K + + + ++ E+L ++ + NV +L+QLE + + + E ++A+
Sbjct: 1314 AKDVASLSSQ-------LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1366
Query: 347 RELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDK 406
+ L + ++ TL +++ + + D T+ L++ ++ TQ ++K
Sbjct: 1367 QNLER-----HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQY---EEK 1418
Query: 407 ADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQT--------------R 452
A +++ K K+R EL L+ N++QL L K ++ +Q R
Sbjct: 1419 AAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADER 1478
Query: 453 DRLAKLNKE-------LASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDR 505
DR +E LA + + EL+R + L + ++ D+ S+D D+ +
Sbjct: 1479 DRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKA---EMEDLVSSKD---DVGK 1532
Query: 506 LKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVF--------QTEAELQE 557
E+EKS +RA+ + +Q + +L DE Q+ R+ Q E +LQ
Sbjct: 1533 NVHELEKS--KRALETQMEEMKTQ-LEELEDELQATEDAKLRLEVNMQALKGQFERDLQA 1589
Query: 558 VISDLQSKLRLAPDKLKSTESELKKKEKRR-----------DEMLGLVPMRQSIIDLKEK 606
+ K R +L E+EL+ + K+R ++ L S I +E+
Sbjct: 1590 RDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE 1649
Query: 607 EIPELRNKLQNVNRDIQRLKNDIE-EQETLLGTIMPEEESAKVCLTDVTIM-------ER 658
I +LR KLQ +D QR D ++ + T E+ AK D+ + ER
Sbjct: 1650 AIKQLR-KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER 1708
Query: 659 FQMELKDVERKIAQQ-AAKLQGID--------LDRTVQQVNQEKQEKQHKLDTVSSKIEL 709
+ + + ++A++ A+ L G + L+ + Q+ +E +E+Q ++ +S ++
Sbjct: 1709 ARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRV-- 1766
Query: 710 NRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDA 769
RK Q Q EQ+ +NEL +E+ N RQQLE Q EL +++ + +K
Sbjct: 1767 -RKATQ-QAEQL------SNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK 1818
Query: 770 -KEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQD 828
K ++ LE + + +++ E+ +K + K + K +KE + + K E Y +
Sbjct: 1819 FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQ 1878
Query: 829 GKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDID 870
+ + K+ + QL E E+ ++IN + R +++++D
Sbjct: 1879 AEKGNARVKQLK-----RQLEEAEEESQRINANRRKLQRELD 1915
Score = 143 bits (360), Expect = 1e-33
Identities = 212/1057 (20%), Positives = 459/1057 (43%), Gaps = 163/1057 (15%)
Query: 46 YIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSY 105
+ K L+ RQ + + KE EL+ K+ ++KA ++ K +QLT K +++
Sbjct: 845 FTKVKPLLQVTRQEEEMQAKED--ELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 902
Query: 106 ---ENE-----------LDPLKNRLKEIEHNL-SKIMKLDNEIKALDSRKKQMEKDNSEL 150
E E L K L+EI H + +++ + ++ + L + +K+M + +L
Sbjct: 903 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 962
Query: 151 EEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVE 210
EE++E+ + ++L + +++ E +++ + KL+KE +LL + S+L
Sbjct: 963 EEQLEEE-EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1021
Query: 211 QGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAK 270
+ +A + +S+I L +L+ + E+ + KL R + EG+A
Sbjct: 1022 LAEEEEKAKNLTKLKNKHESMISELEVRLKKE--------EKSRQELEKLKR-KLEGDA- 1071
Query: 271 TANQLMNDFAEKETLKQKQIDEIR----DKKTGLGRIIELKSEILSKKQNELKNVKYELQ 326
+DF E+ Q QI E++ K+ L + + +++K N LK ++
Sbjct: 1072 ------SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR---- 1121
Query: 327 QLEGS-SDRILELDQE-LIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQ 384
+LEG SD +LD E + + E K + +E LK E+ + A K +Q
Sbjct: 1122 ELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQ 1181
Query: 385 EMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSK 444
E+ L + L ++ + Q+++++ +H+ + L +QLE + +K
Sbjct: 1182 EVTVLK---------KALDEETRSHEAQVQEMRQKHAQAVEEL------TEQLEQFKRAK 1226
Query: 445 SKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLD 504
+ +++ + L K N +LA + E++ K+++L + +L C SD +
Sbjct: 1227 A-NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKC------SDGE 1279
Query: 505 RLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQS 564
R + E+ + +L +E +S + +L + ++ L S
Sbjct: 1280 RARAELNDK-----------------VHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1322
Query: 565 KLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQR 624
+L+ D + + E ++K ++ L R S+ D ++E+ +N ++++ +
Sbjct: 1323 QLQ---DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379
Query: 625 LKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDR 684
L + ++ + T+ EE K RFQ E++++ ++ ++AA
Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKK----------RFQKEIENLTQQYEEKAA--------- 1420
Query: 685 TVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTN-LQ 743
++ + K Q +LD + ++ R+L+ + +++ + ++L +E+ IS+
Sbjct: 1421 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK----QRKFDQLLAEEKNISSKYAD 1476
Query: 744 RRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQD 803
R + E + E T+ SL R +++A E LE T + + E E+L++ K+
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKD-------- 1528
Query: 804 KLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMR 863
+ KN+H K K+ ET++ ++ QL E E + ED +
Sbjct: 1529 ------DVGKNVHELEKS------------KRALETQMEEMKTQLEELEDELQ-ATEDAK 1569
Query: 864 LMRQDIDTQKIQERWLQDNLTLRKRNEELK------------EVEEERKQHLKEMGQMQV 911
L R +++ Q ++ ++ +D ++NEE + E+E+ERKQ + +
Sbjct: 1570 L-RLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ--RALAAAAK 1626
Query: 912 LQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKEL------REPQFRDAEEKY 965
+++ + + LE D+ + A+ + + + ++ F++EL R+ F A+E
Sbjct: 1627 KKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE 1686
Query: 966 REMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKII-RDLWRSTYRGQDIEYI 1024
++ + + +DL + QA ++ + E + + R+ + R +
Sbjct: 1687 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1746
Query: 1025 EIRSDADE---NVSA-SDKRRNYNYRVVMLKGDTALD 1057
++ + +E N+ A SD+ R + L + A +
Sbjct: 1747 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1783
Score = 51.2 bits (121), Expect = 6e-06
Identities = 64/361 (17%), Positives = 151/361 (41%), Gaps = 28/361 (7%)
Query: 717 QQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPL 776
Q+E++Q + + K + + L+ +Q Q E +Q + + + +
Sbjct: 857 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 916
Query: 777 ETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQ 836
L +QE EE++++ + +D+ ++ + K + M D+E +++ ++ +Q
Sbjct: 917 RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE--EEAARQ 974
Query: 837 KETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVE 896
K +L KV A+ + E + D + + + + ++ER L + E+ K +
Sbjct: 975 K-LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1033
Query: 897 EERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREP 956
+ + +H + +++V K E K + ++ +KR G + E+I + ++ E
Sbjct: 1034 KLKNKHESMISELEVRLKKEE--KSRQELEKLKRKLE---GDASDFHEQIADLQAQIAEL 1088
Query: 957 QFRDAEEKYREMMIVMRTTELVN---------KDLDIYYKTLDQAIMKFHSMKMEEINKI 1007
+ + A+++ + R + + ++L+ + L + + + + + K
Sbjct: 1089 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR-NKAEKQ 1147
Query: 1008 IRDLWRSTYRGQDIEYI--EIRSDADENVSASDKRRNYNYRVVMLKGDTALDMRGRCSAG 1065
RDL G+++E + E+ D + + R V +LK ALD R
Sbjct: 1148 KRDL------GEELEALKTELEDTLDSTATQQELRAKREQEVTVLK--KALDEETRSHEA 1199
Query: 1066 Q 1066
Q
Sbjct: 1200 Q 1200
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 149 bits (377), Expect = 1e-35
Identities = 187/882 (21%), Positives = 389/882 (44%), Gaps = 119/882 (13%)
Query: 48 KALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYEN 107
K E L+ ++ + LK +++ + ++++ + S+ A +++ +
Sbjct: 1087 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1146
Query: 108 ELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLND 167
EL+ LK L++ LD+ + R K+ E++ + L++ +++ + + Q+ +
Sbjct: 1147 ELEALKTELEDT---------LDSTATQQELRAKR-EQEVTVLKKALDEETRSHEAQVQE 1196
Query: 168 LYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRA 227
+ H + V E +L R L+K + L +E ++L E R+ QA + EH +
Sbjct: 1197 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL-RVLGQAKQEVEHKKK 1255
Query: 228 R-DSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLK 286
+ ++ +Q L ++ R +++ HKL + E ++ ++N+ K
Sbjct: 1256 KLEAQVQELQSKCSDGERARAELNDK----VHKL-----QNEVESVTGMLNEAEGKAIKL 1306
Query: 287 QKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAE 346
K + + + ++ E+L ++ + NV +L+QLE + + + E ++A+
Sbjct: 1307 AKDVASLSSQ-------LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1359
Query: 347 RELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDK 406
+ L + ++ TL +++ + + D T+ L++ ++ TQ ++K
Sbjct: 1360 QNLER-----HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQY---EEK 1411
Query: 407 ADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQT--------------R 452
A +++ K K+R EL L+ N++QL L K ++ +Q R
Sbjct: 1412 AAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADER 1471
Query: 453 DRLAKLNKE-------LASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDR 505
DR +E LA + + EL+R + L + ++ D+ S+D D+ +
Sbjct: 1472 DRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKA---EMEDLVSSKD---DVGK 1525
Query: 506 LKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVF--------QTEAELQE 557
E+EKS +RA+ + +Q + +L DE Q+ R+ Q E +LQ
Sbjct: 1526 NVHELEKS--KRALETQMEEMKTQ-LEELEDELQATEDAKLRLEVNMQALKGQFERDLQA 1582
Query: 558 VISDLQSKLRLAPDKLKSTESELKKKEKRR-----------DEMLGLVPMRQSIIDLKEK 606
+ K R +L E+EL+ + K+R ++ L S I +E+
Sbjct: 1583 RDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE 1642
Query: 607 EIPELRNKLQNVNRDIQRLKNDIE-EQETLLGTIMPEEESAKVCLTDVTIM-------ER 658
I +LR KLQ +D QR D ++ + T E+ AK D+ + ER
Sbjct: 1643 AIKQLR-KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER 1701
Query: 659 FQMELKDVERKIAQQ-AAKLQGID--------LDRTVQQVNQEKQEKQHKLDTVSSKIEL 709
+ + + ++A++ A+ L G + L+ + Q+ +E +E+Q ++ +S ++
Sbjct: 1702 ARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRV-- 1759
Query: 710 NRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDA 769
RK Q Q EQ+ +NEL +E+ N RQQLE Q EL +++ + +K
Sbjct: 1760 -RKATQ-QAEQL------SNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK 1811
Query: 770 -KEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQD 828
K ++ LE + + +++ E+ +K + K + K +KE + + K E Y +
Sbjct: 1812 FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQ 1871
Query: 829 GKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDID 870
+ + K+ + QL E E+ ++IN + R +++++D
Sbjct: 1872 AEKGNARVKQLK-----RQLEEAEEESQRINANRRKLQRELD 1908
Score = 143 bits (360), Expect = 1e-33
Identities = 212/1057 (20%), Positives = 459/1057 (43%), Gaps = 163/1057 (15%)
Query: 46 YIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSY 105
+ K L+ RQ + + KE EL+ K+ ++KA ++ K +QLT K +++
Sbjct: 838 FTKVKPLLQVTRQEEEMQAKED--ELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 895
Query: 106 ---ENE-----------LDPLKNRLKEIEHNL-SKIMKLDNEIKALDSRKKQMEKDNSEL 150
E E L K L+EI H + +++ + ++ + L + +K+M + +L
Sbjct: 896 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 955
Query: 151 EEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVE 210
EE++E+ + ++L + +++ E +++ + KL+KE +LL + S+L
Sbjct: 956 EEQLEEE-EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1014
Query: 211 QGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAK 270
+ +A + +S+I L +L+ + E+ + KL R + EG+A
Sbjct: 1015 LAEEEEKAKNLTKLKNKHESMISELEVRLKKE--------EKSRQELEKLKR-KLEGDA- 1064
Query: 271 TANQLMNDFAEKETLKQKQIDEIR----DKKTGLGRIIELKSEILSKKQNELKNVKYELQ 326
+DF E+ Q QI E++ K+ L + + +++K N LK ++
Sbjct: 1065 ------SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR---- 1114
Query: 327 QLEGS-SDRILELDQE-LIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQ 384
+LEG SD +LD E + + E K + +E LK E+ + A K +Q
Sbjct: 1115 ELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQ 1174
Query: 385 EMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSK 444
E+ L + L ++ + Q+++++ +H+ + L +QLE + +K
Sbjct: 1175 EVTVLK---------KALDEETRSHEAQVQEMRQKHAQAVEEL------TEQLEQFKRAK 1219
Query: 445 SKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLD 504
+ +++ + L K N +LA + E++ K+++L + +L C SD +
Sbjct: 1220 A-NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKC------SDGE 1272
Query: 505 RLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQS 564
R + E+ + +L +E +S + +L + ++ L S
Sbjct: 1273 RARAELNDK-----------------VHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1315
Query: 565 KLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQR 624
+L+ D + + E ++K ++ L R S+ D ++E+ +N ++++ +
Sbjct: 1316 QLQ---DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1372
Query: 625 LKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDR 684
L + ++ + T+ EE K RFQ E++++ ++ ++AA
Sbjct: 1373 LSDSKKKLQDFASTVEALEEGKK----------RFQKEIENLTQQYEEKAA--------- 1413
Query: 685 TVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTN-LQ 743
++ + K Q +LD + ++ R+L+ + +++ + ++L +E+ IS+
Sbjct: 1414 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK----QRKFDQLLAEEKNISSKYAD 1469
Query: 744 RRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQD 803
R + E + E T+ SL R +++A E LE T + + E E+L++ K+
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKD-------- 1521
Query: 804 KLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMR 863
+ KN+H K K+ ET++ ++ QL E E + ED +
Sbjct: 1522 ------DVGKNVHELEKS------------KRALETQMEEMKTQLEELEDELQ-ATEDAK 1562
Query: 864 LMRQDIDTQKIQERWLQDNLTLRKRNEELK------------EVEEERKQHLKEMGQMQV 911
L R +++ Q ++ ++ +D ++NEE + E+E+ERKQ + +
Sbjct: 1563 L-RLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ--RALAAAAK 1619
Query: 912 LQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKEL------REPQFRDAEEKY 965
+++ + + LE D+ + A+ + + + ++ F++EL R+ F A+E
Sbjct: 1620 KKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE 1679
Query: 966 REMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKII-RDLWRSTYRGQDIEYI 1024
++ + + +DL + QA ++ + E + + R+ + R +
Sbjct: 1680 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1739
Query: 1025 EIRSDADE---NVSA-SDKRRNYNYRVVMLKGDTALD 1057
++ + +E N+ A SD+ R + L + A +
Sbjct: 1740 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1776
Score = 51.2 bits (121), Expect = 6e-06
Identities = 64/361 (17%), Positives = 151/361 (41%), Gaps = 28/361 (7%)
Query: 717 QQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPL 776
Q+E++Q + + K + + L+ +Q Q E +Q + + + +
Sbjct: 850 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 909
Query: 777 ETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQ 836
L +QE EE++++ + +D+ ++ + K + M D+E +++ ++ +Q
Sbjct: 910 RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE--EEAARQ 967
Query: 837 KETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVE 896
K +L KV A+ + E + D + + + + ++ER L + E+ K +
Sbjct: 968 K-LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1026
Query: 897 EERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREP 956
+ + +H + +++V K E K + ++ +KR G + E+I + ++ E
Sbjct: 1027 KLKNKHESMISELEVRLKKEE--KSRQELEKLKRKLE---GDASDFHEQIADLQAQIAEL 1081
Query: 957 QFRDAEEKYREMMIVMRTTELVN---------KDLDIYYKTLDQAIMKFHSMKMEEINKI 1007
+ + A+++ + R + + ++L+ + L + + + + + K
Sbjct: 1082 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR-NKAEKQ 1140
Query: 1008 IRDLWRSTYRGQDIEYI--EIRSDADENVSASDKRRNYNYRVVMLKGDTALDMRGRCSAG 1065
RDL G+++E + E+ D + + R V +LK ALD R
Sbjct: 1141 KRDL------GEELEALKTELEDTLDSTATQQELRAKREQEVTVLK--KALDEETRSHEA 1192
Query: 1066 Q 1066
Q
Sbjct: 1193 Q 1193
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 147 bits (370), Expect = 8e-35
Identities = 207/1000 (20%), Positives = 435/1000 (43%), Gaps = 135/1000 (13%)
Query: 48 KALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYEN 107
K + ++Q Q V E Q +L+ K+ E +++ + +L S +E+V EN
Sbjct: 500 KISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELEN 559
Query: 108 ELDPLKNR--------------LKEIEHNLSK--------IMKLDNEIKALDSRKKQMEK 145
+ L+ + LKE+E ++ I KL N + +D+ K+ E+
Sbjct: 560 TIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCER 619
Query: 146 DNS---ELEEKMEKVFQGTDE---QLNDLYHNHQRTVREKER---KLVDCHRELEKLNKE 196
+ EL +K+E+ Q E ++N+L + T++EK++ KL +++ L+++
Sbjct: 620 EERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSED 679
Query: 197 SRLLNQEKSELLVEQGRL-----QLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSE 251
+L+ E L E +L QL D + D +++ TQLE ++
Sbjct: 680 KEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLE----KKLQLMV 735
Query: 252 RQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEIL 311
+ N +KL+ Q + QL E + ++ E ++K + +++ E L
Sbjct: 736 EEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGS----EVSEDSEEKDVVN-VLQAVGESL 790
Query: 312 SKKQNELKNVKYELQQLEGSSDRILELDQEL--IKAERELSKAEKNSNVETLKMEVISLQ 369
+K E N+ ++ +++LEL++E+ ++ E + E S + + E + L+
Sbjct: 791 AKINEEKCNLAFQ------RDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLR 844
Query: 370 NEKADLDRTLRKLDQEM-EQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLL 428
E ++ L ++ E N + TR + + L + + K + + E +
Sbjct: 845 KELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIK 904
Query: 429 GYFPNKKQLEDW-LHSKSKEINQTRDRLAKL----NKELASSEQNKNHINN---ELKRKE 480
+ K LE L + E+ +D LAK N L+S ++ + I N E K KE
Sbjct: 905 EHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKE 964
Query: 481 EQLSSYEDKLFDVCGSQDFES---DLDRLKEEIEK--------SSKQRAMLAGATAVYSQ 529
E+++ KL V ++ +S + +KEE+E S+ R ++ GA + Y
Sbjct: 965 EKINKI--KLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAES-YKN 1021
Query: 530 FITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDE 589
+ + +++ +R E ++ DL +LR + + ++ S+ ++
Sbjct: 1022 LLLEYEKQSEQLDVEKERANNFEHRIE----DLTRQLRNSTLQCETINSD-------NED 1070
Query: 590 MLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVC 649
+L + QS L E +I E++ V+++++ K E++ T + E E +V
Sbjct: 1071 LLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQ 1130
Query: 650 LTDVTIMERFQMELKDVERKIAQQAA--KLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKI 707
L + M+ ++ +K AQQ ++ D +R ++++NQ+ K +K++ + +I
Sbjct: 1131 LQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEI 1190
Query: 708 ELNRKLIQDQQEQIQHLKSTTNE-----LKSEKLQISTNLQRRQQLEEQTVELSTEVQSL 762
++ ++ + QE+I L+S+ + K ++L + T + + +T L + SL
Sbjct: 1191 KIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQA-SL 1249
Query: 763 YREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKV---------- 812
E++ +++QV + L + EK ++ TS + Q L+ +++V
Sbjct: 1250 KGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAA 1309
Query: 813 --------KNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRL 864
Y + N ++ K+ Q ETE K + +H E + + +++
Sbjct: 1310 KAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAK------QEREHLEMLIDQLKI 1363
Query: 865 MRQD------IDTQKIQERWLQDNLTLRKRNEELKEV---EEERKQHLKEMGQMQVLQMK 915
QD I+ ++Q + + L + N+ L+E E E ++ L + Q + + MK
Sbjct: 1364 KLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSI-QSENMMMK 1422
Query: 916 SEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELRE 955
SEH + + + +N L + + +++ H ++E R+
Sbjct: 1423 SEHTQTVSQLTS--QNEVL----RNSFRDQVRHLQEEHRK 1456
Score = 120 bits (302), Expect = 6e-27
Identities = 237/1178 (20%), Positives = 491/1178 (41%), Gaps = 196/1178 (16%)
Query: 95 LTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMK-LDNEIKALDSRKKQMEKDNSELEEK 153
+ +K E E++ L++ K + I+K L + AL K + E+ L+++
Sbjct: 41 IQKAKSRCTELEKEIEELRS--KPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKE 98
Query: 154 MEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGR 213
K+ Q ++ + + H +E E+ ++ +E+E L E + + SE ++
Sbjct: 99 NIKMKQEVEDSVTKMGDAH----KELEQSHINYVKEIENLKNELMAVRSKYSE---DKAN 151
Query: 214 LQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTAN 273
LQ Q + +++ TQLEL E+ F N KL E ++
Sbjct: 152 LQKQLE-------------EAMNTQLELS--EQLKFQNNSEDNVKKLQEEIEK------- 189
Query: 274 QLMNDFAEKETLKQKQIDEIRDKK----TGLGRIIELKSEILSKKQNELKNVKYELQQLE 329
+ F E+ QKQ+D D+K T L IIE S+ K N L+ +L+ +
Sbjct: 190 -IRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIH 248
Query: 330 GSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQL 389
+ L E E E + N E L + +A +K + E+E L
Sbjct: 249 QEEVKELMCQIEASAKEHEAEINKLNELKENLVKQC------EASEKNIQKKYECELENL 302
Query: 390 NHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEIN 449
T+ A++D QI I + + + ++ K LED L + +
Sbjct: 303 RKATSN-----------ANQDNQICSILLQENTFVEQVVN--EKVKHLEDTLKELESQHS 349
Query: 450 QTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEE 509
+D + +N E + HI +E + E L ++L + ++ +++LK E
Sbjct: 350 ILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINEL--LLAKEEQGCVIEKLKSE 407
Query: 510 IEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLA 569
+ +KQ +++ + L +++Q F +++E +++ L +++
Sbjct: 408 LAGLNKQ---FCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLT--LMFEIQGL 462
Query: 570 PDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQ------------N 617
++ ++ + E +++ +L +R+ I+++ + E+ E K+ +
Sbjct: 463 KEQCENLQQE------KQEAILNYESLRE-IMEILQTELGESAGKISQEFESMKQQQASD 515
Query: 618 VNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERK-------I 670
V+ Q+L+ E++ LL T+ + + L+ ++ + +K+++ K +
Sbjct: 516 VHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSL 575
Query: 671 AQQAAKLQGIDLDRTVQQVNQEKQEKQHKL-------DTVSSKIELNRKLIQDQQEQIQH 723
+Q+ L+ +L+ + + +EK + +KL D K E +LI + ++++
Sbjct: 576 SQRDTMLK--ELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQ 633
Query: 724 LKSTTNELKSEKLQISTNL--------QRRQQLEEQTVE----------LSTEVQSLYRE 765
+EL+ + +++ L Q Q+LE+ V+ LS EV+SLY E
Sbjct: 634 TIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEE 693
Query: 766 IKDAKEQVSPLETTLEKFQQEKEELINKKNTSN---KIA-----QDKLNDIKEKVK---- 813
+ L LE F +KE++I K++ + K+ QD LN + E +
Sbjct: 694 NNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKL 753
Query: 814 ----NIHGYMKDIENYIQDGKDDYKKQKETELNKV---IAQLSECEKHKEKINEDMRLMR 866
++G++K++ + + + D +K L V +A+++E EK D +++
Sbjct: 754 FVKTQLYGFLKEMGSEVSE--DSEEKDVVNVLQAVGESLAKINE-EKCNLAFQRDEKVLE 810
Query: 867 QDIDTQKIQER--------------WLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVL 912
+ + + +QE + Q+ + LRK EE++ +E + L EM
Sbjct: 811 LEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANE- 869
Query: 913 QMKSEHQKLEENIDNIKRN------HNLALGRQKGYEEEIIHFKKELREPQFRDAEEKYR 966
+ + E+Q L ++ + + HN ++K + +E + K L + + RD +
Sbjct: 870 KTRLENQNLLIQVEEVSQTCSKSEIHN---EKEKCFIKEHENLKPLLEQKELRDRRAELI 926
Query: 967 EMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSM---KMEEINKII-------RDLWRSTY 1016
+ + + V D K L++ I K E+INKI ++L S
Sbjct: 927 LLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRK 986
Query: 1017 RGQDI--EYIEIRSDADENVSASDK---RRNYNYRVVML---KGDTALDM-RGRCSAGQK 1067
Q + E +RS+ D+ +SAS + + +Y+ ++L K LD+ + R + +
Sbjct: 987 ETQTVKEELESLRSEKDQ-LSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEH 1045
Query: 1068 VLASLIIRLALAETFCLNCGIIALDEPTTNLDRENIESLAHALVEIIKSRSQQRNFQLLV 1127
+ L +L + C T N D E++ A +E ++S ++ Q+L
Sbjct: 1046 RIEDLTRQLRNSTLQC----------ETINSDNEDLL----ARIETLQSNAKLLEVQILE 1091
Query: 1128 ITHDEDFVELLGRSEYVEKFYRIKKNIDQCSEIVKCSV 1165
+ + V+ +E ++K +IK++ +E+ + V
Sbjct: 1092 VQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQV 1129
Score = 115 bits (288), Expect = 2e-25
Identities = 195/1026 (19%), Positives = 427/1026 (41%), Gaps = 154/1026 (15%)
Query: 42 SATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQ--YKEKACEIRDQITSKEAQLT--- 96
+ T+ +E Q Q ++E ++LK + Q KE C+I EA++
Sbjct: 215 TVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLN 274
Query: 97 ------------SSKEIVKSYENELDPLKNRLKEI--EHNLSKIMKLDN---------EI 133
S K I K YE EL+ L+ ++ + I+ +N ++
Sbjct: 275 ELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKV 334
Query: 134 KALDSRKKQMEKDNSELEEKMEKV------FQGTDEQLNDLYHNHQRTVREKERKLVDCH 187
K L+ K++E +S L++++ + + + + D + + + + K +L+
Sbjct: 335 KHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAK 394
Query: 188 RE----LEKLNKESRLLNQEKSELLVEQGR-LQLQADRHQEHIRA------RDSLIQSLA 236
E +EKL E LN++ + + R +Q ++HQ+ I DS + L
Sbjct: 395 EEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLT 454
Query: 237 TQLELDGFERGPFSERQIK--------NFHKLVRERQEGEAKTANQLMNDFAEKETLKQK 288
E+ G + + +Q K + +++ Q ++A ++ +F E++KQ+
Sbjct: 455 LMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEF---ESMKQQ 511
Query: 289 QIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERE 348
Q ++ + + L K +L + ++ E ++L + + EL+ + + +
Sbjct: 512 QASDVHELQQKLRTAFTEKDALLET----VNRLQGENEKLLSQQELVPELENTIKNLQEK 567
Query: 349 -----LSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLT 403
LS +++++ ++ L+ ++ SL EK D L+ +EM+ N H + E L
Sbjct: 568 NGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMD--NFHKKCERE-ERLI 624
Query: 404 KDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAK----LN 459
+ K EQ + S ++ L G + +D K +++ L++ L+
Sbjct: 625 LELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLS 684
Query: 460 KELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQ---DFESDLDRLKEEIEKSSK- 515
E+ S + N +++E K+ L + + DV + E L + EE + +K
Sbjct: 685 AEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKL 744
Query: 516 ----QRAMLAGATAVYSQFITQL------TDENQSCCPVCQRVFQTEAELQEVISDLQSK 565
Q L T +Y F+ ++ E + V Q V ++ A++ E +L +
Sbjct: 745 LENEQVQKLFVKTQLYG-FLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQ 803
Query: 566 LRLAPDKLKSTESELKKKEKRR----DEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRD 621
+K+ E E+K ++ +E+ L+ + L KE+ E++++ + + D
Sbjct: 804 ---RDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSD 860
Query: 622 IQRLKNDIE----EQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVE--------RK 669
+ +KN E E + LL + EE ++ C E+ + +K+ E ++
Sbjct: 861 LLEMKNANEKTRLENQNLLIQV---EEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKE 917
Query: 670 IAQQAAKLQGI-------------------DLDRTVQQVNQEKQEKQHKLDTVSSKIELN 710
+ + A+L + +L+ ++ + +E +EK+ K++ +
Sbjct: 918 LRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKA 977
Query: 711 RKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAK 770
+K + +++ Q +K L+SEK Q+S +++ Q E L E + ++ K
Sbjct: 978 KKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEK 1037
Query: 771 EQVSPLETTLEKFQQEKEELINKKNTSNKIAQD---KLNDIKEKVKNIHGYMKDIEN--- 824
E+ + E +E ++ + T N +D ++ ++ K + + +++
Sbjct: 1038 ERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKA 1097
Query: 825 YIQDGKDDYKKQKE----------TELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKI 874
+ + K QKE EL ++ QL + +K +K +++ L+++D +
Sbjct: 1098 MVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTL 1157
Query: 875 QERWLQD--------NLTLRKRNEELKEVEEERK--QHLKEMGQMQVLQMKSEHQKLEEN 924
+ D N L +N +++++E+E K + +E Q ++ ++S Q+ EE
Sbjct: 1158 MNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEK 1217
Query: 925 IDNIKR 930
IK+
Sbjct: 1218 NTKIKQ 1223
Score = 95.1 bits (235), Expect = 3e-19
Identities = 170/872 (19%), Positives = 360/872 (41%), Gaps = 119/872 (13%)
Query: 12 LNNVIFCHQEDSNWPLSEGKALKQKFDEIFSATRYIKALETLRQVRQTQGQKVKEYQMEL 71
L I C QE+S E K+L + +++ R +++ + Q +K + Q +L
Sbjct: 811 LEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLR--------KELEEIQSEK-EALQSDL 861
Query: 72 KYLKQYKEKAC-----------EIRDQITSKEAQLTSSKEIVKSYEN-----ELDPLKNR 115
+K EK E+ + E K +K +EN E L++R
Sbjct: 862 LEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDR 921
Query: 116 LKEI---EHNLSKIMKLDNE----IKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDL 168
E+ + +L+K + N+ +K L+ + + +EK+ E EEK+ K+ + +L
Sbjct: 922 RAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKEL 981
Query: 169 YHNHQRTVREKERKLVDCHRELEKLNKESRLLNQ---EKSELLVEQGRLQLQADRHQEHI 225
+ + T KE +L E ++L+ R L Q LL+E + Q D +E
Sbjct: 982 DSSRKETQTVKE-ELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERA 1040
Query: 226 RARDSLIQSLATQLE--------LDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMN 277
+ I+ L QL ++ + + + + E Q E + A +++
Sbjct: 1041 NNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVD 1100
Query: 278 DFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILE 337
E E L+++Q +I++ T + + EL+ + L K++ +L+ EL+ ++ + +
Sbjct: 1101 KELEAEKLQKEQ--KIKEHATTVNELEELQVQ-LQKEKKQLQKTMQELELVKKDAQQTTL 1157
Query: 338 LDQELIKAERELSK-----AEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHH 392
++ E+ ER + + KN+ +E L+ E+ + ++ L + L ++Q
Sbjct: 1158 MNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEK 1217
Query: 393 TT------TRTQMEMLTKDKADKDEQIRKIKSRHSDELTS---------LLGYFPNKKQL 437
T +T+ E+ +A+ D I + + E + L K ++
Sbjct: 1218 NTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKI 1277
Query: 438 EDWLHSKSKEINQT----RDRLAKLNKELASS-----------EQNKNHINNELKRKEEQ 482
+ L + +++ +T + R+ L +E ++ E K ++N LK+++ +
Sbjct: 1278 HEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNK 1337
Query: 483 LSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAM-LAGATAVYSQFITQLTDENQSC 541
S + + E +D+LK +++ S + ++ + S+ T L N+
Sbjct: 1338 SMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNK-- 1395
Query: 542 CPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESEL-KKKEKRRDEMLGLVPMRQSI 600
+ Q EAEL+E + +QS+ + + T S+L + E R+ R +
Sbjct: 1396 --MLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSF------RDQV 1447
Query: 601 IDLKE---KEIPELRNKLQNVNRDIQRLKND------IEEQETLLGTIMPEEESAKVCLT 651
L+E K + L+ +L + + +LKN+ + Q++L + E + + L
Sbjct: 1448 RHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKN--LRERRNTDLPLL 1505
Query: 652 DVTIMERFQ---MELKDVERKIAQQAAKLQGID---------LDRTVQQVNQEKQEKQHK 699
D+ + R + ME D E ++ + Q ++ L+ + K+E K
Sbjct: 1506 DMHTVTREEGEGMETTDTE-SVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQK 1564
Query: 700 LDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEV 759
L + + + L+++ + L LKSE ++ N +R + + +
Sbjct: 1565 LSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVLL 1624
Query: 760 QSLYREIKDAKEQVSP-LETTLEKFQQEKEEL 790
Q ++ + +E++ P + T L+ +EK +L
Sbjct: 1625 QFIFLKPGSERERLLPVINTMLQLSPEEKGKL 1656
Score = 51.6 bits (122), Expect = 4e-06
Identities = 81/384 (21%), Positives = 171/384 (44%), Gaps = 69/384 (17%)
Query: 640 MPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAK----------------LQGIDLD 683
+P+E+ K + ++++ + ++E++I + +K L + L+
Sbjct: 25 LPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLE 84
Query: 684 R--TVQQVNQEKQE----KQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNEL---KSE 734
+ T QQ K+E KQ D+V+ + +++L Q ++ +++ NEL +S+
Sbjct: 85 KAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSK 144
Query: 735 KLQISTNLQRRQQLEE---QTVELSTE----------VQSLYREIKDAK----EQVSPLE 777
+ NLQ+ QLEE +ELS + V+ L EI+ + EQ+ L+
Sbjct: 145 YSEDKANLQK--QLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQ 202
Query: 778 TTLEKFQQEKEELI----NKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDY 833
L+ EK+E + N +++ Q +N ++E++ + ++ + +
Sbjct: 203 KQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEAS 262
Query: 834 KKQKETELNKVIA----QLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDN---LTLR 886
K+ E E+NK+ + +CE ++ I + +++ +K QDN L
Sbjct: 263 AKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENL--RKATSNANQDNQICSILL 320
Query: 887 KRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEI 946
+ N +++V E+ +HL++ + +++S+H L+ D + +NL L E +
Sbjct: 321 QENTFVEQVVNEKVKHLED----TLKELESQHSILK---DEVTYMNNLKL----KLEMDA 369
Query: 947 IHFKKELREPQFRDAEEKYREMMI 970
H K E + D E K E+++
Sbjct: 370 QHIKDEFFHER-EDLEFKINELLL 392
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 144 bits (364), Expect = 4e-34
Identities = 220/1027 (21%), Positives = 452/1027 (44%), Gaps = 161/1027 (15%)
Query: 47 IKALETLRQVRQTQGQKVKEYQMELKYLKQY-----KEKACEIRDQITSKEAQLTSSKEI 101
+K LETL+Q + Q +K + ++ K+ EK +++Q+ + +L K++
Sbjct: 278 VKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEA-LQEQLDERLQELEKIKDL 336
Query: 102 VKSYEN----ELDPLKNRLKEIEHNLSKIMK------------LDNEIKALDSRKKQMEK 145
+ + +L KN ++++E + ++ + EI L SR KQM
Sbjct: 337 HMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTT 396
Query: 146 DNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLV----DCHRELEKLNKESRL-L 200
EL E+ EK + E+L Q+T E RKL + + +EK ++E R+ L
Sbjct: 397 QGEELREQKEKSERAAFEELEKALSTAQKT-EEARRKLKAEMDEQIKTIEKTSEEERISL 455
Query: 201 NQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKL 260
QE S V+Q + + +E I L + + E + ++ ER+ + K+
Sbjct: 456 QQELSR--VKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKV 513
Query: 261 VRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKN 320
E+ + E +Q EKE + ++E+ + K IL++ +N+L++
Sbjct: 514 ALEKSQSEYLKISQ------EKEQQESLALEELELQ----------KKAILTESENKLRD 557
Query: 321 VKYELQQLEGSSDRILELDQELIKAERELS----------KAEKNSN-------VETLKM 363
++ Q+ E RILEL+ L K+ +E +AEKN + VE K
Sbjct: 558 LQ---QEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKT 614
Query: 364 EVISLQNEKADL-DRTLRKLDQ----EMEQLNHHTTTRTQMEMLTKDK-----ADKDEQI 413
E+ SL++++ L L+ L Q EME+L + E L KDK A +E
Sbjct: 615 ELESLKHQQDALWTEKLQVLKQQYQTEMEKLRE--KCEQEKETLLKDKEIIFQAHIEEMN 672
Query: 414 RKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKEL-ASSEQNKNH- 471
K + + T L ++ H +E++ +D+ K+ +EL A ++ KNH
Sbjct: 673 EKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHH 732
Query: 472 ---INNELKRKEEQLSSYEDKLFDVCGS------------QDFESDLDRLKEEIEKSSKQ 516
+++ +K E + E L D ++ ++ ++ L+ +I++S +
Sbjct: 733 QQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGE 792
Query: 517 RAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTE-AELQEVISDLQSKLRLAPDKLKS 575
+ V+ + QS + ++ + A+LQ+ + DL+++ L ++
Sbjct: 793 LQQASAKLDVFQSY--------QSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQV-- 842
Query: 576 TESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDI-QRLKNDIEEQET 634
E E +KK+ + +D + ++ +L +L+ N ++ Q++K+ + E+
Sbjct: 843 AEVEAQKKDVCTE------------LDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYES 890
Query: 635 LLGTIMPEEESAKVCLTD-----VTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQV 689
L E+E K L + + + E + E++ + +K++ + + ++ + +
Sbjct: 891 KLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFK 950
Query: 690 NQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQ------------ 737
NQEK+ ++ K + L +KL+ + + + L++T EL ++ Q
Sbjct: 951 NQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQAN 1010
Query: 738 ---ISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKK 794
IS + R + +++ +E TEV RE+ D + +K Q+ EEL
Sbjct: 1011 SAGISDAVSRLETNQKEQIESLTEVHR--RELNDV------ISIWEKKLNQQAEELQEIH 1062
Query: 795 NTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKH 854
+ + ++ ++K+K+ +++ I K++ KQ +T LN++ QL + H
Sbjct: 1063 EIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQ-DTTLNELQEQLKQKSAH 1121
Query: 855 KEKINEDMRLMRQDIDTQKIQ-ERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQ 913
+ +D ++ ++ ++ + L++N L+++ ELK + EE K+ +V +
Sbjct: 1122 VNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKR--------KVSE 1173
Query: 914 MKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFR-DAEEKYREMMIVM 972
+ S+ + +E ++K +H + K E++ + FKK E + D K E ++
Sbjct: 1174 LTSKLKTTDEEFQSLKSSHEKS---NKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEA 1230
Query: 973 RTTELVN 979
+T EL+N
Sbjct: 1231 KTNELIN 1237
Score = 131 bits (330), Expect = 3e-30
Identities = 207/1053 (19%), Positives = 448/1053 (42%), Gaps = 159/1053 (15%)
Query: 28 SEGKALKQKFDEIFSATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQ 87
+E ++LK + D +++ + L+ L+Q QT+ +K++E K +EK ++D+
Sbjct: 614 TELESLKHQQDALWT-----EKLQVLKQQYQTEMEKLRE--------KCEQEKETLLKDK 660
Query: 88 ITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKA-LDSRKKQMEKD 146
+A + E K+ E +LD + L+ + LS+++K ++++ L K Q +K
Sbjct: 661 EIIFQAHIEEMNE--KTLE-KLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKM 717
Query: 147 NSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQE--- 203
ELE KM++ +Q++ + H+ +++ E+ L D +LE L KE +E
Sbjct: 718 KQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQA 777
Query: 204 -----KSELLVEQGRLQ-----------LQADRHQEHIRARDSLIQSLATQLELDGFERG 247
++++ +G LQ Q+ H++ + L Q L+L+
Sbjct: 778 HVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLE----- 832
Query: 248 PFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQ---KQIDEIRDKKTGLGRII 304
+ER + K V E + + +L + + L Q KQ E+ K L ++
Sbjct: 833 --TERIL--LTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVY 888
Query: 305 ELKSEILSKKQNELKNVKYE-----LQQLEGSSDRILELDQELI---------------- 343
E K E +K+Q + K + E LQ EG I L Q+L
Sbjct: 889 ESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETK 948
Query: 344 --KAERELSKAEKNSN--VETLKMEVISLQNE-KADLDRTLRKLDQEMEQLNHHTTTRTQ 398
E+++ K ++ + ETLK +++ + + K +L+ T +L Q+ +Q N
Sbjct: 949 FKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFN-----AKM 1003
Query: 399 MEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKL 458
+EM + A + + ++++ +++ SL ++++L D + K++NQ + L ++
Sbjct: 1004 LEMAQANSAGISDAVSRLETNQKEQIESLTEV--HRRELNDVISIWEKKLNQQAEELQEI 1061
Query: 459 NKELASSEQNKNHINNELKRKEEQLSSYEDK-LFDVCGSQDFESDLDRLKEEIEKSSKQR 517
++ +L+ KE++++ + K L C ++ ++ LKEE K
Sbjct: 1062 HE-------------IQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQD--- 1105
Query: 518 AMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTE 577
T L + + +++ Q A + + D ++KL+ +KL E
Sbjct: 1106 --------------TTLNE-------LQEQLKQKSAHVNSLAQD-ETKLKAHLEKL---E 1140
Query: 578 SELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLG 637
+L K K + + + + + ++++ EL +KL+ + + Q LK+ E+ L
Sbjct: 1141 VDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSL- 1199
Query: 638 TIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQ 697
E++S + + + + K E + + +L I +T + Q
Sbjct: 1200 ----EDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKT-NAILSRISHCQ 1254
Query: 698 HKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQ----QLEEQTV 753
H+ V + + + + + Q++ L N L Q + L+ ++ ++
Sbjct: 1255 HRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIE 1314
Query: 754 ELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVK 813
L TE ++L +E + ++ S E+ + + ++E E IN + + +++L + K ++
Sbjct: 1315 SLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENIN----AVTLMKEELKEKKVEIS 1370
Query: 814 NIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQK 873
++ + D+ +Q+ +KE ++ + Q E + +D+ + +K
Sbjct: 1371 SLSKQLTDLNVQLQNSIS--LSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEK 1428
Query: 874 IQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQV---LQMKSEHQK------LEEN 924
I D+ + K +E K+ + QH + ++Q+ L+ K ++K L+E
Sbjct: 1429 ISALEQVDDWS-NKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEE 1487
Query: 925 IDNIKRNHNLALGRQKG----YEEEIIHFKKELREPQFRDAE------EKYREMMIVMRT 974
+D + + G + E++ + + EL+ R E +K E+ +
Sbjct: 1488 LDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEV 1547
Query: 975 TELVNKDLDIYYKTLDQAIMKFHSMKMEEINKI 1007
+ N+ DI +K L Q + F + E+ N++
Sbjct: 1548 LKNYNQQKDIEHKELVQKLQHFQELGEEKDNRV 1580
Score = 127 bits (318), Expect = 8e-29
Identities = 230/1096 (20%), Positives = 457/1096 (41%), Gaps = 180/1096 (16%)
Query: 7 VSKAVLNNVIFCHQEDSNWPLSEGKALKQKFDEIFSATRYIKALETLRQVRQTQGQKVKE 66
V + LN+VI ++ N E Q+ EI + + E L+Q G + +E
Sbjct: 1035 VHRRELNDVISIWEKKLNQQAEE----LQEIHEIQLQEKEQEVAE-LKQKILLFGCEKEE 1089
Query: 67 YQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKI 126
E+ +LK E+ + + + QL V S + LK L+++E +L+K
Sbjct: 1090 MNKEITWLK---EEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKS 1146
Query: 127 MKLDNEIKA-LDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVD 185
+K + ++ L K E+D ++ E K+ + TDE+ L +H+++ + E K ++
Sbjct: 1147 LKENTFLQEQLVELKMLAEEDKRKVSELTSKL-KTTDEEFQSLKSSHEKSNKSLEDKSLE 1205
Query: 186 CHRELEKL--------NKESRLLNQEKSELL-VEQGRLQLQADR--HQEH--IRARDSLI 232
+ E+L K LL + +EL+ + + R H +H + +++L+
Sbjct: 1206 FKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALL 1265
Query: 233 QSLATQLELDGFERGPFSERQIKNF------HKLVRERQEGEAKTAN-QLMNDFAEKETL 285
T EL+ R E+ N H+L E +E + K+ + + EKE L
Sbjct: 1266 IKTCTVSELEAQLRQLTEEQNTLNISFQQATHQL--EEKENQIKSMKADIESLVTEKEAL 1323
Query: 286 KQKQIDEIRDKKTGLGRIIELKSEI------LSKKQNELKNVKYELQQLEGS-SDRILEL 338
+++ ++ + I +LK E+ ++ + ELK K E+ L +D ++L
Sbjct: 1324 QKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQL 1383
Query: 339 DQELIKAERELS-----------KAEKNSNVETLKMEVISLQNEK----ADLDRTLRKLD 383
+ +E+E + K E V+ L +V +L EK +D K
Sbjct: 1384 QNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFS 1443
Query: 384 Q----EMEQLNHHTTT----RTQMEMLTKDKADKDEQIR--------------------- 414
+ + H T + Q+E+ +K+ +KDEQI
Sbjct: 1444 EWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEME 1503
Query: 415 ----KIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLN-------KELA 463
K++ + S+ T L +LED + K+ EI + L N KEL
Sbjct: 1504 DDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELV 1563
Query: 464 SSEQNKNHI----NNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEK-----SS 514
Q+ + +N +K EE++ + E++++ + +++L+ K+E+E S
Sbjct: 1564 QKLQHFQELGEEKDNRVKEAEEKILTLENQVYSM------KAELETKKKELEHVNLSVKS 1617
Query: 515 KQRAMLAGATAVYSQFITQLTD----ENQSCCPVCQRVFQTEAELQEV--------ISDL 562
K+ + A + S+ +L + Q + +++ E +E +S+L
Sbjct: 1618 KEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSEL 1677
Query: 563 QSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRD- 621
+KL+ ++ E +LK E + E L + +++ E+E + + +Q +
Sbjct: 1678 NTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEK 1737
Query: 622 IQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGID 681
I L+ ++ E+E LL + E+E T+ F+M + ER I + A+ + +
Sbjct: 1738 ISVLQRNLTEKEKLLQRVGQEKEE--------TVSSHFEMRCQYQERLIKLEHAEAKQHE 1789
Query: 682 LDRTVQQVNQEKQEKQHKLDTV----------SSKIELNRKL---IQDQQEQIQHLKSTT 728
+ + +E +EK K + + I+ + L D Q+ +Q + T
Sbjct: 1790 DQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTC 1849
Query: 729 NELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQE-K 787
L+ + ++ + L R++++ +E T + ++ + P E E +++ K
Sbjct: 1850 QILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSK 1909
Query: 788 EELINKKNTSNKIAQDKLNDIKEKV-----------KNIHGYMKDIENYIQDGKDD---Y 833
L+ K SN AQ ND++ K+ K I KD+ ++ + +
Sbjct: 1910 SHLVQPKLLSNMEAQH--NDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEIL 1967
Query: 834 KKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELK 893
KK+ + E + I Q E E + K N ++ + ++ +TQ Q+ + +T+++ + +
Sbjct: 1968 KKEYDQEREEKIKQ--EQEDLELKHNSTLKQLMREFNTQLAQKE-QELEMTIKETINKAQ 2024
Query: 894 EVEEE-RKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKE 952
EVE E + H +E Q+ +K+ E D++KR K Y EEI+ ++E
Sbjct: 2025 EVEAELLESHQEETNQLL--------KKIAEKDDDLKRT-------AKRY-EEILDAREE 2068
Query: 953 LREPQFRDAEEKYREM 968
+ RD + + E+
Sbjct: 2069 EMTAKVRDLQTQLEEL 2084
Score = 97.8 bits (242), Expect = 5e-20
Identities = 141/693 (20%), Positives = 302/693 (43%), Gaps = 102/693 (14%)
Query: 352 AEKNSNVETLKMEVISLQNEKADLDRTLRK------LDQEMEQLNHHTTTRTQMEMLTKD 405
+ K S V T E ++ + DLD + +D E E L ++ + + +++ +
Sbjct: 88 SSKESLVRTSSRESLN----RLDLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRL 143
Query: 406 KADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASS 465
+ + + + ++S+ +T+ KK+L+ L S+ +++ R+A+L +EL
Sbjct: 144 RR-MERSLSSYRGKYSELVTAYQMLQREKKKLQGIL---SQSQDKSLRRIAELREELQMD 199
Query: 466 EQNKNHINNE----LKRKEE-------QLSSYEDKLFDVCGSQDFESDLDRL-------- 506
+Q K H+ E L+ K++ Q+S + +L + + D L +L
Sbjct: 200 QQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFT 259
Query: 507 KEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAE-----------L 555
KEE +S + + G + + + Q ++ C+ Q+ E L
Sbjct: 260 KEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEAL 319
Query: 556 QEVISDLQSKLRLAPD-------KLKSTESELKKKEKRRDEMLGLV-----PMRQSIIDL 603
QE + + +L D KL + + K ++ ++ G+V +++
Sbjct: 320 QEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEM 379
Query: 604 KEKEIPELRNKLQNVNRDIQRLKND--------IEEQETLLGTIMPEEESAKVCLTDVTI 655
KE+EI +LR++++ + + L+ EE E L T EE+ + ++
Sbjct: 380 KEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDE 439
Query: 656 MERFQMELKDVERKIAQQ---AAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRK 712
+ + + ER QQ K + +D+ + + K +K H+ + + EL +K
Sbjct: 440 QIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKK 499
Query: 713 LIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVEL---------STEVQSLY 763
L ++E + +K + +SE L+IS ++++ L + +EL +++ L
Sbjct: 500 LQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQ 559
Query: 764 REIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIE 823
+E + + ++ LE++LEK QE + K+ + + +K KE + + ++E
Sbjct: 560 QEAETYRTRILELESSLEKSLQENKN--QSKDLAVHLEAEKNKHNKEITVMVEKHKTELE 617
Query: 824 N--YIQDG-----KDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQ---DIDTQK 873
+ + QD K+Q +TE+ K+ +CE+ KE + +D ++ Q + +K
Sbjct: 618 SLKHQQDALWTEKLQVLKQQYQTEMEKL---REKCEQEKETLLKDKEIIFQAHIEEMNEK 674
Query: 874 IQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQM--------QVLQMKSEHQK--LEE 923
E+ L + EL EV + R + +E+ + Q L+ K + QK ++
Sbjct: 675 TLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQ 734
Query: 924 NIDNIKRNHNLALGR-QKGYEEEIIHFKKELRE 955
+D+I + H +++ R +K +++I + L+E
Sbjct: 735 QVDSIIKEHEVSIQRTEKALKDQINQLELLLKE 767
Score = 84.3 bits (207), Expect = 6e-16
Identities = 146/695 (21%), Positives = 291/695 (41%), Gaps = 109/695 (15%)
Query: 65 KEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELD-------------- 110
KE +E + LK + E+ D IT K ++ S E++K+Y + D
Sbjct: 1512 KESNLETE-LKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQ 1570
Query: 111 ----PLKNRLKEIEHNLSKIMKLDNEIKA----LDSRKKQMEKDNSELEEKMEKVFQGTD 162
NR+KE E KI+ L+N++ + L+++KK++E N ++ K E++ D
Sbjct: 1571 ELGEEKDNRVKEAEE---KILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALED 1627
Query: 163 EQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQ 222
++ R+ E+K+ ++L +E ++ +E + + +LQ +
Sbjct: 1628 RLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQERERE 1687
Query: 223 EHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEK 282
HI + L ++Q E R KN + ++ EA + + + EK
Sbjct: 1688 VHI-LEEKLKSVESSQSET------LIVPRSAKN---VAAYTEQEEADSQGCVQKTYEEK 1737
Query: 283 ETLKQKQIDEIRDKKTGLGRIIELKSEILSKK-----QNELKNVKYELQQLEGSSDRIL- 336
++ Q+ + E K+ L R+ + K E +S Q + + +K E + + D+ +
Sbjct: 1738 ISVLQRNLTE---KEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMI 1794
Query: 337 -ELDQELIKAERELS-----KAEKNSNVETLKMEVISLQNEKADLDRTLRK-------LD 383
L +EL + ++ S EK ++ + +L+N D+ +TL++ L+
Sbjct: 1795 GHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQ-NLENVFDDVQKTLQEKELTCQILE 1853
Query: 384 QEMEQLN-----HHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLE 438
Q++++L+ R +ME LT K +K + ++++ R+ T LL +K
Sbjct: 1854 QKIKELDSCLVRQKEVHRVEMEELTS-KYEKLQALQQMDGRNKP--TELLEENTEEKSKS 1910
Query: 439 DWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQD 498
+ K ++ + L +LA +E+ K + E+ R ++ L ++
Sbjct: 1911 HLVQPKL--LSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLR---------KE 1959
Query: 499 FESDLDRLKEEI--EKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQ 556
+ +L+ LK+E E+ K + ++ + QL E + + Q+ + E ++
Sbjct: 1960 HQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNT--QLAQKEQELEMTIK 2017
Query: 557 EVISDLQS-KLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKL 615
E I+ Q + L + T LKK ++ D++ + I+D +E+E+ L
Sbjct: 2018 ETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDL 2077
Query: 616 QNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAA 675
Q ++Q+ EQE G +VTIME ++ ++AQ+
Sbjct: 2078 QTQLEELQKKYQQKLEQEENPGN------------DNVTIME--------LQTQLAQKTT 2117
Query: 676 KLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELN 710
+ L QE +E+ H L+ K E N
Sbjct: 2118 LISDSKLK------EQEFREQIHNLEDRLKKYEKN 2146
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 144 bits (363), Expect = 5e-34
Identities = 195/989 (19%), Positives = 432/989 (43%), Gaps = 110/989 (11%)
Query: 95 LTSSKEIVKSYENELDPLKNRLKEIEHNLS----KIMKLDNEIKALDSRKKQMEKDNSEL 150
L S+ E+ K YE D + E NL+ + L E++ L + K+ + + EL
Sbjct: 50 LGSADELFKHYEAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEEL 109
Query: 151 EEKMEKVFQGTDEQL---NDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSEL 207
++++EK +QG +Q + L + ++ E++L + E + + L Q+ ++L
Sbjct: 110 KKELEK-YQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQL 168
Query: 208 LVEQGRLQLQADRHQEHIRARDSLIQSLATQLE-----LDGFERGPFSERQIKNFHKLVR 262
E ++ + D + A + + L +L + + I++ L +
Sbjct: 169 ATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKK 228
Query: 263 ERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVK 322
E + + N + E E LK + + I +L+SE L+K E+
Sbjct: 229 ELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSE-LAKGPQEVAVYV 287
Query: 323 YELQQLEGSSDRILE----LDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRT 378
ELQ+L+ S + + + L + L+K E++ +K E+ N E++ K ++ T
Sbjct: 288 QELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVS---------KKNIQAT 338
Query: 379 LRKLDQEMEQLNHH-TTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQL 437
L + D + +QL + + T + + + ++K E +K+K S+ T KQL
Sbjct: 339 LHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQL 398
Query: 438 EDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGS- 496
+ K + Q + + +L+ +L +E+ + LK ++ QLSS +KL D
Sbjct: 399 QQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLK-EQRQLSS--EKLMDKEQQV 455
Query: 497 QDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQ 556
D + L RL+E++++ + +T + Q + + ++Q + Q T A+L+
Sbjct: 456 ADLQLKLSRLEEQLKEK------VTNSTELQHQ-LDKTKQQHQEQQALQQ---STTAKLR 505
Query: 557 EVISDLQSKLRLAPDK----------LKSTESELKKKEKRRDEMLGLVPMRQS----IID 602
E +DL+ LR DK L+ ++ + EK R+++ + + +
Sbjct: 506 EAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQ 565
Query: 603 LKEK------EIPELRNKLQNVNRDIQRLKNDIEEQ------------------ETLLGT 638
L+EK ++ +L KL+N + ++ + ++ +Q ET +
Sbjct: 566 LQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNE 625
Query: 639 IMPE--EESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEK 696
+ + E KV D+ I + ++ L K AQ+A DL + Q+K
Sbjct: 626 LNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRA------DLQNHLDTAQNALQDK 679
Query: 697 QHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQ----QLEEQT 752
Q +L+ ++++++ +QD+QE L+S E K + L + + + +LE +
Sbjct: 680 QQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADS 739
Query: 753 VELSTEVQSLYREIKDAKEQVSPLE---TTLEKFQQEKEELINKKNTSNKIAQDKLNDIK 809
+E+ + ++++ ++ + LE T L K + ++E+++ + + L IK
Sbjct: 740 LEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIK 799
Query: 810 EKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKV---IAQLSECEKHKEKINEDMRLMR 866
+K+ + ++ + + K Q E N++ + +L + + KE + ++ ++
Sbjct: 800 QKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVK 859
Query: 867 QDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKS---EHQKLEE 923
+ K+ + K N++ K + ++ KE+ +QM++ E ++L++
Sbjct: 860 DKL--SKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKK 917
Query: 924 NIDNIKR-NHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKYREMMIVMRTTELVNKDL 982
+++ K +H L L +E++I + L++ + ++ ++ + + +++E K +
Sbjct: 918 SLEKEKEASHQLKL-ELNSMQEQLIQAQNTLKQNE-KEEQQLQGNINELKQSSEQKKKQI 975
Query: 983 DIYYKTLDQAIMKFHSMKMEEINKIIRDL 1011
+ L A+++ K E NK+ + L
Sbjct: 976 EALQGELKIAVLQ----KTELENKLQQQL 1000
Score = 136 bits (342), Expect = 1e-31
Identities = 192/982 (19%), Positives = 420/982 (42%), Gaps = 98/982 (9%)
Query: 33 LKQKFDEIFSATRYIKA-LETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSK 91
LK++ E+ + +++KA + L+Q R+ + Q + Q E+ Q K E Q+
Sbjct: 377 LKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEIN---QLHSKLLETERQLGEA 433
Query: 92 EAQLTSSKEI----VKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDN 147
+L +++ + E ++ L+ +L +E L + + E++ + KQ ++
Sbjct: 434 HGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQ 493
Query: 148 SELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSEL 207
L++ + L + R + +K++K+ + L+K + LL +E+ +L
Sbjct: 494 QALQQSTTAKLREAQNDLEQVL----RQIGDKDQKIQNLEALLQKSKENISLLEKEREDL 549
Query: 208 LVEQGRLQLQADRHQ----EHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRE 263
+ +QA + ++ ++ +Q TQL + ++ +N H V+E
Sbjct: 550 YAK-----IQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQE 604
Query: 264 RQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEIL-----------S 312
Q+ + A + Q++E ++K + L I+ K+E+L +
Sbjct: 605 -QKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRA 663
Query: 313 KKQNELKNVKYELQQLEGSSDRIL-ELDQELIKAE-RELSKAEKNSNVETLKMEVISLQN 370
QN L + LQ + ++I +LDQ K + ++ ++ S+++ K + +SL+
Sbjct: 664 DLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQ 723
Query: 371 EKADLDRTLRKLD-----------QEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKS- 418
+ +L+ ++KL+ Q ++ L T +E+ + + + E ++I S
Sbjct: 724 KTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSS 783
Query: 419 ------RHSDELTSLLGYFPNKKQLEDWLHSKSKEINQ-TRDRLAKLNKELASSEQNKNH 471
+ S+ L S+ +++ + L + ++Q T+ + +LN + ++
Sbjct: 784 TRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQK 843
Query: 472 INNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSS-KQRAMLAGATAVYSQF 530
+ E + +LS+ +DKL V S L K E EK + K +A + +
Sbjct: 844 VKMEKEALMTELSTVKDKLSKVSDS------LKNSKSEFEKENQKGKAAILDLEKTCKEL 897
Query: 531 ITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEM 590
QL + ++ + + ++ + +E L+ +L ++L ++ LK+ EK ++
Sbjct: 898 KHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQL 957
Query: 591 LGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLG-TIMPEEESAKVC 649
G + + + K+K+I L+ +L+ L+N +++Q T + E+E V
Sbjct: 958 QGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVL 1017
Query: 650 LTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIEL 709
+ E+ Q K ++ + ++L Q+ + + KL +
Sbjct: 1018 QNN---YEKSQETFKQLQSDFYGRESELLA---------TRQDLKSVEEKLSLAQEDLIS 1065
Query: 710 NRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRR-QQLEEQTVELSTEVQSLYR---- 764
NR I +Q + IQ LK+ L+ + + LQ R + L++ E S + + L
Sbjct: 1066 NRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSK 1125
Query: 765 --EIKDAK----EQVSPLETTLEKFQQEK-EELINKKNTSNKIAQDKLNDIKEKVKNIHG 817
EI++ K ++++ L L+ + E +E+ N K+ + Q KL +++ K ++
Sbjct: 1126 LAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKL-ELQGKADSLKA 1184
Query: 818 YMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQER 877
++ + Q KD KK++E EL K + E + H E + +++ +K +E
Sbjct: 1185 AVEQEKRNQQILKDQVKKEEE-ELKKEFIE-KEAKLHSE-------IKEKEVGMKKHEEN 1235
Query: 878 WLQDNLTLRKRNEELKEVEEERKQHLKEMGQM--QVLQMKSEHQKLEENIDNIKRNHNLA 935
+ + + NE L V++E + + + ++ Q ++ E LE + N +
Sbjct: 1236 EAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRAL 1295
Query: 936 LGRQKGYEEEIIHFKKELREPQ 957
L R E EI + ++ E Q
Sbjct: 1296 LERCLKGEGEIEKLQTKVLELQ 1317
Score = 89.7 bits (221), Expect = 1e-17
Identities = 125/555 (22%), Positives = 243/555 (43%), Gaps = 59/555 (10%)
Query: 29 EGKALKQKFDEIFSATRYI-KALETLRQVRQTQGQKVK-EYQMELKYLKQYKEKACEIRD 86
E + LKQ F+ + T+ + L Q T+ QKVK E + + L K+K ++ D
Sbjct: 808 EKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSD 867
Query: 87 QITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKD 146
+ + +++ KE K LD L+ KE++H L ++++N +K KK +EK+
Sbjct: 868 SLKNSKSEF--EKENQKGKAAILD-LEKTCKELKHQLQ--VQMENTLKEQKELKKSLEKE 922
Query: 147 NSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSE 206
E +++ EQL Q T+++ E++ + +L + S Q+K +
Sbjct: 923 K-EASHQLKLELNSMQEQLIQA----QNTLKQNEKEEQQLQGNINELKQSSE---QKKKQ 974
Query: 207 LLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQE 266
+ QG L++ + E + A +L + K +++ E
Sbjct: 975 IEALQGELKIAVLQKTELENKLQQQLTQAAQELAAE------------KEKISVLQNNYE 1022
Query: 267 GEAKTANQLMNDF--AEKETLKQKQIDEIRDKKTGLGR--IIELKSEILSKKQ--NELKN 320
+T QL +DF E E L +Q + ++K L + +I +++I ++ + ELK
Sbjct: 1023 KSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKT 1082
Query: 321 VKYELQQLEGSSDRILELDQELIKAERELSKAE--KNSNVETLKMEVISLQNEKADLDRT 378
K L+Q ++ L QE KA +++ K + K + K ++ ++ K ++
Sbjct: 1083 AKATLEQDSAKKEQQL---QERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKE 1139
Query: 379 LRKLDQEM-----EQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPN 433
+ KL++E+ E + T + ++L + K + + +K+ E N
Sbjct: 1140 ITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKR-------N 1192
Query: 434 KKQLEDWLHSKSKEINQTR-DRLAKLNKELASSEQN-KNHINNELKRKEEQLSSYEDKLF 491
++ L+D + + +E+ + ++ AKL+ E+ E K H NE K Q+++ + L
Sbjct: 1193 QQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTM-QITALNENLG 1251
Query: 492 DVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQT 551
V ++++S R+ E KQ L G AV + DE ++ C +
Sbjct: 1252 TV--KKEWQSSQRRVSE----LEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGE 1305
Query: 552 EAELQEVISDLQSKL 566
+LQ + +LQ KL
Sbjct: 1306 IEKLQTKVLELQRKL 1320
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 144 bits (362), Expect = 6e-34
Identities = 212/1072 (19%), Positives = 456/1072 (42%), Gaps = 175/1072 (16%)
Query: 47 IKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYE 106
IK L + + +E+Q L + + K E+ +++ + L ++ +
Sbjct: 839 IKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVT---LLKEKNDLQLQVQ 895
Query: 107 NELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLN 166
+E D L + + E + ++L+ +IK + R ++ E+ N+EL K K+ E
Sbjct: 896 SEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKK 955
Query: 167 DLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIR 226
D+ + + T+ + E++ +++ L +E L++ ++L E+ LQ + + ++
Sbjct: 956 DI-DDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQ 1014
Query: 227 ARDSLIQSLA---TQLE--LDGFERGPFSERQIKNFHKLVRERQEGEAKTA--------- 272
A + + L T+LE +D E E++++ + + + EG+ K A
Sbjct: 1015 AEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMEN 1074
Query: 273 -NQLMNDFAEKETLK------------------QKQIDEIRDKKTGLGRIIELK--SEIL 311
Q +++ EK+ + QK+I E++ + LG IE + S
Sbjct: 1075 DKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAK 1134
Query: 312 SKKQ-----NELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKME-- 364
++KQ EL+ + L++ G++ +EL++ K E E K ++ TL+ E
Sbjct: 1135 AEKQRSDLSRELEEISERLEEAGGATSAQVELNK---KREAEFQKLRRDLEEATLQHEAM 1191
Query: 365 VISLQNEKAD-----------LDRTLRKLDQEMEQLNHHT-TTRTQMEMLTKDKAD---- 408
V +L+ + AD L R +KL++E +L T + E ++K K +
Sbjct: 1192 VAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKM 1251
Query: 409 ---KDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASS 465
++Q+ ++K++ ++ + + +L+ S+++++ +++L++ +S
Sbjct: 1252 CRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQAS 1311
Query: 466 EQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATA 525
Q + ++L+ + + ++ L Q D D L+E+ E+ + +A L A +
Sbjct: 1312 TQQIEELKHQLEEETKAKNALAHAL------QSSRHDCDLLREQYEEEQEGKAELQRALS 1365
Query: 526 VYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEK 585
+ + Q + ++ Q EL+E L +L+ A + +++ ++ EK
Sbjct: 1366 KANSEVAQWRTKYET------DAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEK 1419
Query: 586 RRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEES 645
+ + V ++ L K +N ++ + K EE + L E S
Sbjct: 1420 TKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRS 1479
Query: 646 AKVCLTDVTIM---------------ERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVN 690
L V + + Q E+ D+ +IA+ ++ +L++ +QV
Sbjct: 1480 LSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIH--ELEKIKKQVE 1537
Query: 691 QEKQEKQHKLDTVSS------------KIELNR------KLIQDQQEQIQHLK------- 725
QEK E Q L+ + ++ELN+ + I ++ E+I LK
Sbjct: 1538 QEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVV 1597
Query: 726 ----STTN-ELKSEKLQISTNLQRRQQLEEQTVELS-------------TEVQSLYREI- 766
ST + E++S + + L E ++L+ Q + +E
Sbjct: 1598 ETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQ 1657
Query: 767 ----------KDAKEQVSPLETTLEKFQQEKEEL---INKKNTSNKIAQDKLNDIKEKVK 813
+D KEQ++ +E Q E EEL + + S KIA+ +L D E+V+
Sbjct: 1658 LHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQ 1717
Query: 814 NIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDI---- 869
+H + N + ++D Q ++E+ +VI + E+ +K D +M +++
Sbjct: 1718 LLHTQNTSLINTKKKLENDV-SQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQ 1776
Query: 870 DTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDN-I 928
DT ER ++ L + ++L+ +E +Q + G+ Q+ ++++ ++LE ++N
Sbjct: 1777 DTSAHLERMKKN---LEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQ 1833
Query: 929 KRNHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKYREMMIVMRTTELVNK 980
KRN G +K ++ ++E ++ E++ V+R +LV+K
Sbjct: 1834 KRNAEAVKGLRK--------HERRVKELTYQTEEDRKN----VLRLQDLVDK 1873
Score = 134 bits (337), Expect = 5e-31
Identities = 225/1083 (20%), Positives = 445/1083 (41%), Gaps = 216/1083 (19%)
Query: 51 ETLRQVRQTQGQKVK-EYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENEL 109
++L + Q +K + Q+E K +K+ E+A E ++I A+LT+ K + E+E
Sbjct: 899 DSLADAEERCEQLIKNKIQLEAK-IKEVTERA-EEEEEIN---AELTAKK---RKLEDEC 950
Query: 110 DPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLY 169
LK + ++E L+K+ K E A +++ K + ++ + L+E + K+ ++ L
Sbjct: 951 SELKKDIDDLELTLAKVEK---EKHATENKVKNLTEEMAGLDETIAKL----SKEKKALQ 1003
Query: 170 HNHQRTVREKERKLVDCHRELEKLN---KESRLLNQEKSEL---LVEQGRLQLQADRHQE 223
HQ+T L D E +K+N K L Q+ +L L ++ +L++ +R +
Sbjct: 1004 ETHQQT-------LDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKR 1056
Query: 224 HIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKE 283
+ L Q +E D ++Q+ KL E++E E + D E
Sbjct: 1057 KLEGDLKLAQESTMDMEND--------KQQLDE--KL--EKKEFEISNLISKIEDEQAVE 1104
Query: 284 TLKQKQIDEIRDKKTGLGRIIELK--SEILSKKQN-----ELKNVKYELQQLEGSSDRIL 336
QK+I E++ + LG IE + S ++KQ EL+ + L++ G++ +
Sbjct: 1105 IQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQV 1164
Query: 337 ELDQELIKAERELSKAEKNSNVETLKME--VISLQNEKAD-----------LDRTLRKLD 383
EL++ K E E K ++ TL+ E V +L+ + AD L R +KL+
Sbjct: 1165 ELNK---KREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLE 1221
Query: 384 QEMEQLNHHTTT-RTQMEMLTKDKADKD-------EQIRKIKSRHSDELTSLLGYFPNKK 435
+E +L T + E ++K K + + +Q+ ++K++ ++ + +
Sbjct: 1222 KEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRA 1281
Query: 436 QLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCG 495
+L+ S+++++ +++L++ +S Q + ++L+ + + ++ L
Sbjct: 1282 RLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHAL----- 1336
Query: 496 SQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAEL 555
Q D D L+E+ E+ + +A L A + + + Q + ++ Q EL
Sbjct: 1337 -QSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYET------DAIQRTEEL 1389
Query: 556 QEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKL 615
+E L +L+ A + +++ ++ EK + + V ++ L K
Sbjct: 1390 EEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQ 1449
Query: 616 QNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIM---------------ERFQ 660
+N ++ + K EE + L E S L V + + Q
Sbjct: 1450 RNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQ 1509
Query: 661 MELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSS------------KIE 708
E+ D+ +IA+ ++ +L++ +QV QEK E Q L+ + ++E
Sbjct: 1510 QEISDLTEQIAEGGKQIH--ELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLE 1567
Query: 709 LNR------KLIQDQQEQIQHLK-----------STTN-ELKSEKLQISTNLQRRQQLEE 750
LN+ + I ++ E+I LK ST + E++S + + L E
Sbjct: 1568 LNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNE 1627
Query: 751 QTVELS-------------TEVQSLYREIK-----------DAKEQVSPLETTLEKFQQE 786
++L+ Q + +E + D KEQ++ +E Q E
Sbjct: 1628 MEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAE 1687
Query: 787 KEEL---INKKNTSNKIAQDKLNDIKEKVKNIHGY------------------MKDIENY 825
EEL + + S KIA+ +L D E+V+ +H ++E
Sbjct: 1688 IEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEV 1747
Query: 826 IQDGKDDYKKQKET---------ELNKVIAQLSECEKHKEKINEDMRLMRQDIDT----- 871
IQ+ ++ +K K+ EL K + E+ K+ + + ++ ++ +D
Sbjct: 1748 IQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLA 1807
Query: 872 --------QKI--------------QERWLQDNLTLRKRNEELKEV----EEERKQHLKE 905
QK+ Q+R + LRK +KE+ EE+RK L+
Sbjct: 1808 LKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRL 1867
Query: 906 MGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKY 965
+ LQ K + K + + N NL+ R+ +E E + ++ E Q K
Sbjct: 1868 QDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVNKLRVKS 1927
Query: 966 REM 968
RE+
Sbjct: 1928 REV 1930
Score = 117 bits (293), Expect = 6e-26
Identities = 189/894 (21%), Positives = 370/894 (41%), Gaps = 144/894 (16%)
Query: 175 TVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIR-ARDSLIQ 233
T++E+ +K D EL K + + L ++ LL E+ LQLQ + + A + Q
Sbjct: 854 TMKEEFQKTKD---ELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQ 910
Query: 234 SLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEI 293
+ +++L E +IK + E +E A+ + E LK K ID++
Sbjct: 911 LIKNKIQL---------EAKIKEVTERAEEEEEINAELTAKKRKLEDECSELK-KDIDDL 960
Query: 294 --------RDKKTGLGRIIELKSEI---------LSKKQNELKNVKYE-LQQLEGSSDRI 335
++K ++ L E+ LSK++ L+ + L L+ D++
Sbjct: 961 ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKV 1020
Query: 336 LELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKA---DLDRTLRKLDQEMEQLNHH 392
L + K E+++ E SL+ EK DL+R RKL+ +++
Sbjct: 1021 NILTKAKTKLEQQVDDLEG------------SLEQEKKLRMDLERAKRKLEGDLKLAQES 1068
Query: 393 TTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTR 452
T M+M DK DE++ K + E+++L+ +++ +E L K KE+
Sbjct: 1069 T-----MDM-ENDKQQLDEKLEKKEF----EISNLISKIEDEQAVEIQLQKKIKELQA-- 1116
Query: 453 DRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEK 512
R+ +L +E+ + ++ + +L ++L + G+ + +L++ +E +
Sbjct: 1117 -RIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREA--E 1173
Query: 513 SSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDK 572
K R L AT + + L ++ + AEL E I +LQ K
Sbjct: 1174 FQKLRRDLEEATLQHEAMVAALRKKHAD----------SMAELGEQIDNLQR----VKQK 1219
Query: 573 LKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQ 632
L+ +SELK + + + ++ + + + ++L+ + QRL ND+ Q
Sbjct: 1220 LEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQ 1279
Query: 633 ETLLGTIMPEEESAKVCLTDVTIMERFQMELKDV---ERKIAQQAAKLQGIDLDRTVQQV 689
L T E Q++ KD + ++QA+ Q +L +++
Sbjct: 1280 RARLQTEAGEYSR--------------QLDEKDALVSQLSRSKQASTQQIEELKHQLEEE 1325
Query: 690 NQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTN-----LQR 744
+ K H L + +L R+ +++QE L+ ++ SE Q T +QR
Sbjct: 1326 TKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQR 1385
Query: 745 RQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDK 804
++LEE +L+ +Q ++ + + LE T ++ Q E E+L+ SN
Sbjct: 1386 TEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACA-- 1443
Query: 805 LNDIKEKVKNIHGYMKDIENYIQDGKDDYK-KQKE-----TELNKVIAQLSECEKHKEKI 858
+ +K +N + + + ++ + + + QKE TEL KV E E +
Sbjct: 1444 --ALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETL 1501
Query: 859 NEDMRLMRQDI---------------DTQKIQERWLQDNLTLRKRNEELKEVEEERKQHL 903
+ + ++Q+I + +KI+++ Q+ ++ EE + E + +
Sbjct: 1502 RRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKI 1561
Query: 904 KEMGQMQVLQMKSEHQK----LEENIDNIKRNHNLAL-GRQKGYEEEI------IHFKKE 952
+ Q+++ Q+KSE + +E ID +KRNH + Q + EI + KK+
Sbjct: 1562 LRI-QLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKK 1620
Query: 953 LR------EPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMK 1000
+ E Q A E + R T+ + K+ ++ LD A+ +K
Sbjct: 1621 MEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLH---LDDALRGQEDLK 1671
Score = 70.5 bits (171), Expect = 9e-12
Identities = 122/602 (20%), Positives = 256/602 (42%), Gaps = 92/602 (15%)
Query: 62 QKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEH 121
Q+ +E + K L Q ++A E + + +K A L +K+ + +NE++ L + ++E
Sbjct: 1384 QRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRL---QNEVEDL---MLDVER 1437
Query: 122 NLSKIMKLD----NEIKALDSRKKQMEKDNSELEE-------------KMEKVFQGTDEQ 164
+ + LD N K L K++ E+ +ELE K++ V++ + +Q
Sbjct: 1438 SNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQ 1497
Query: 165 LNDLYH---NHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRH 221
L L N Q+ + + ++ + +++ +L K + + QEK E+ Q L+ +A+
Sbjct: 1498 LETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEI---QAALE-EAEAS 1553
Query: 222 QEHIRARDSLIQSLATQLELDGFERGPFSER---QIKNFHKLVRERQEGEAKTANQLMND 278
EH + IQ Q++ + + + Q+K H V E + + ND
Sbjct: 1554 LEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRND 1613
Query: 279 FAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILEL 338
+K+K ++ + + L L +E L +N + L++ + D L
Sbjct: 1614 ALR---VKKKMEGDLNEMEIQLNHANRLAAESL----RNYRNTQGILKETQLHLDDALRG 1666
Query: 339 DQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLD----QEMEQLNH--H 392
++L + +L+ E+ +N+ ++E + E+ + R + + + E QL H +
Sbjct: 1667 QEDL---KEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQN 1723
Query: 393 TTTRTQMEMLTKDKADKDEQIRKI--KSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQ 450
T+ + L D + ++ ++ +SR+++E KK + D ++E+ +
Sbjct: 1724 TSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKA--------KKAITD-AAMMAEELKK 1774
Query: 451 TRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEI 510
+D A L + + EQ + + L E+ K Q E+ + L+ E+
Sbjct: 1775 EQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQI-----QKLEARVRELEGEV 1829
Query: 511 EKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAE------LQEVISDLQS 564
E K+ A + + + +LT +QTE + LQ+++ LQ+
Sbjct: 1830 ENEQKRNAEAVKGLRKHERRVKELT-------------YQTEEDRKNVLRLQDLVDKLQA 1876
Query: 565 KL----RLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNR 620
K+ R A + + + + L K K + E+ + D+ E ++ +LR K + V+
Sbjct: 1877 KVKSYKRQAEEAEEQSNANLSKFRKLQHEL----EEAEERADIAESQVNKLRVKSREVHT 1932
Query: 621 DI 622
I
Sbjct: 1933 KI 1934
Score = 38.9 bits (89), Expect = 0.029
Identities = 49/263 (18%), Positives = 118/263 (44%), Gaps = 20/263 (7%)
Query: 753 VELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKV 812
++L +++ L + + KE + T E+FQ+ K+EL K K ++K+ + ++
Sbjct: 833 MKLFFKIKPLLKSAETEKE----MATMKEEFQKTKDELA-KSEAKRKELEEKMVTLLKEK 887
Query: 813 KNIHGYMKDIENYIQDGKDDYKK--QKETELNKVIAQLSECEKHKEKINEDMRLMRQDID 870
++ ++ + + D ++ ++ + + +L I +++E + +E+IN ++ ++ ++
Sbjct: 888 NDLQLQVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLE 947
Query: 871 TQKIQ-ERWLQD-NLTLRKRNEELKEVEEERKQHLKEMGQMQ--VLQMKSEHQKLEENID 926
+ + ++ + D LTL K +E E + K +EM + + ++ E + L+E
Sbjct: 948 DECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQE--- 1004
Query: 927 NIKRNHNLALGRQKGYEEE--IIHFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDI 984
H L + E++ I+ K E Q D E + + E + L+
Sbjct: 1005 ----THQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEG 1060
Query: 985 YYKTLDQAIMKFHSMKMEEINKI 1007
K ++ M + K + K+
Sbjct: 1061 DLKLAQESTMDMENDKQQLDEKL 1083
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 143 bits (361), Expect = 8e-34
Identities = 175/1007 (17%), Positives = 437/1007 (43%), Gaps = 129/1007 (12%)
Query: 74 LKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNR-------LKEIEHNLSKI 126
+ Y ++ +++++I E + +KE ++ ENE + L ++ LK ++ ++K+
Sbjct: 1835 INNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKM 1894
Query: 127 MKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDC 186
L+ +I+ SR ++++ E ++ +E+ +LN N+ + V + + K
Sbjct: 1895 NLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELL 1954
Query: 187 HRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFER 246
E++ L K L +EK +L+ E + +++++ +E++ ++ G ++
Sbjct: 1955 ESEMKNLKKCVSELEEEKQQLVKE--KTKVESEIRKEYLE-------------KIQGAQK 1999
Query: 247 GPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIEL 306
P ++ K +L++E+Q+ E K + + EK + ++ + + +T + +E+
Sbjct: 2000 EPGNKSHAKELQELLKEKQQ-EVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEI 2058
Query: 307 KSEILS-------KKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVE 359
E L+ K Q EL + K L + + R+L A+ K E SN E
Sbjct: 2059 TKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVL--------ADNLKLKKELQSNKE 2110
Query: 360 TLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKA------------ 407
++K + ++ + DL+R L + ++ + L + +++ L ++K
Sbjct: 2111 SVKSQ---MKQKDEDLERRLEQAEE--KHLKEKKNMQEKLDALRREKVHLEETIGEIQVT 2165
Query: 408 --DKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASS 465
KD+++++++ +T L + + L+D + + I++ + K + + S
Sbjct: 2166 LNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQD---DRDRVIDEAKKWERKFSDAIQSK 2222
Query: 466 EQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATA 525
E+ E++ KE+ S +D+L + ++ LK I + + +
Sbjct: 2223 EE-------EIRLKEDNCSVLKDQL------RQMSIHMEELKINISRLEHDKQIWESKAQ 2269
Query: 526 VYSQFITQLTD----ENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELK 581
Q ++ D EN+ + Q ++ L+S+L+ D+L + L+
Sbjct: 2270 TEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLE 2329
Query: 582 KKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIE-EQETLLGTIM 640
K ++++ + G++ +++ I + +L LQ RL +I +++ ++ +
Sbjct: 2330 KCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLS 2389
Query: 641 PEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLD--RTVQQVNQEKQE-KQ 697
+EE+ +V + + + ++ E+K++E ++Q+ + ++ + + V + NQ + K
Sbjct: 2390 GKEEAIQVAIAE--LRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKT 2447
Query: 698 HKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVE--- 754
K + + K +L+ + Q + + + E+ +S L++ Q ++E E
Sbjct: 2448 IKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNK 2507
Query: 755 LSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNT-----------SNKIAQD 803
L E++ L + D + + L+ L +++++ ++I K++ NK ++
Sbjct: 2508 LKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELEN 2567
Query: 804 KLNDIKEKVKNIHGYMKDIE---NYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINE 860
K ++EK+K +D+ N +Q+ K D K E+ + +S+ + + E
Sbjct: 2568 KYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSK----EIESLKVSISQLTRQVTALQE 2623
Query: 861 DMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEE----RKQHLKEMGQMQVLQMKS 916
+ L + +E + + + + E+EEE +K+ K++G+++
Sbjct: 2624 EGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIE------ 2677
Query: 917 EHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFR-------------DAEE 963
KL++ + ++ + + + EE + ++L E + + +
Sbjct: 2678 --DKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQS 2735
Query: 964 KYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIRD 1010
R M + + + N++LD + D ++ + +K + + RD
Sbjct: 2736 FGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERD 2782
Score = 129 bits (323), Expect = 2e-29
Identities = 222/1081 (20%), Positives = 456/1081 (42%), Gaps = 145/1081 (13%)
Query: 65 KEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIE-HNL 123
++ Q L Y +Q E++D I K+ QL E ++ D N++K+++ H
Sbjct: 48 EDVQERLAYAEQL---VVELKDIIRQKDVQLQQKDEALQEERKAAD---NKIKKLKLHAK 101
Query: 124 SKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKL 183
+K+ L+ I+ + ++ + + EE++ K + + E+ ++ + ++EKE +
Sbjct: 102 AKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEI-EKIKHKLQEKEELI 160
Query: 184 VDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDG 243
+L + E + + E V ++ Q +E I S +Q+ +Q + +
Sbjct: 161 STLQAQLTQAQAEQPAQSSTEMEEFV---MMKQQLQEKEEFI----STLQAQLSQTQAEQ 213
Query: 244 FERGPFSERQIKNFHKLVRERQEGEAKTANQ--LMNDFAEKETLKQKQIDEIRDKKTGLG 301
+ E+ + F VR ++ + Q + + +K + Q++++E + G
Sbjct: 214 AAQQVVREKDAR-FETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRA 272
Query: 302 RIIELKSEILSKKQNELKNVKYELQQLEGSSDRI---LELDQE---LIKAERELSKAEKN 355
++++L + L+ + + + +LQQ+E + + +E ++E ++ + EL AE+
Sbjct: 273 QVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERK 332
Query: 356 SNVETLKMEVISLQNE-------KADLDRTLRKLDQ----EMEQLNHH--TTTRTQMEML 402
+ L+ E+ L + +A+L+ L+Q EME+ H + +T E+
Sbjct: 333 LSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQ 392
Query: 403 TKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKEL 462
+ A KD+ + ++ ++ + S +QLED L KSKEI+Q +RL E
Sbjct: 393 SACDALKDQNSKLLQDKNEQAVQSA----QTIQQLEDQLQQKSKEISQFLNRLPLQQHET 448
Query: 463 ASSEQNKNHINNELKR-KEEQLSSYEDKLFDVCGSQD----FESDLDRLKEEIEKSSKQR 517
AS + N + EE ++S + ++ ++ + +L+ LK E EK S Q
Sbjct: 449 ASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQI 508
Query: 518 AML--AGATAVYSQFITQL----------TDENQSCCPVCQRVF-QTEAELQEVISDLQS 564
+L T + ++++ + +S V + F Q EL ++ +++
Sbjct: 509 TLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKE 568
Query: 565 --------KLRLAPDKLKSTESE-LKKKEKRRDEMLGLVPMRQSI-----------IDLK 604
KL+L + + + E L +KE ++ E G+ P++ + + +
Sbjct: 569 AQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNE 628
Query: 605 EKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELK 664
E +P + K Q R +I + + +++ K I + Q EL+
Sbjct: 629 ESSLPAV-EKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELE 687
Query: 665 DVERKIAQ------QAAKLQGIDLD---RTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQ 715
++ +I + +A ++ +LD + + +NQ +E + D SS +
Sbjct: 688 RLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERD 747
Query: 716 DQQEQIQHLKSTTNELKSEKLQISTNL-----QRRQQLEEQTVE---LSTEVQSLYREIK 767
Q++ L T EL+++ Q+ NL QRR E QT L+ ++ SL E K
Sbjct: 748 QLLSQVKELSMVT-ELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAK 806
Query: 768 DAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQ 827
++ L+ L+ Q + E + Q+K +++ E + + +E Q
Sbjct: 807 SKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQ 866
Query: 828 DGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDID------TQK-------- 873
QKE E+ K+ L E ++ E + + + Q + T+K
Sbjct: 867 -----ALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEK 921
Query: 874 ----IQERWLQDNLTLRKRNEELK--EVEEER------KQHLKEM---GQMQVLQMKSEH 918
++ + L++ L L R EE K +VEE+ KQ+ EM GQ+ +++ E
Sbjct: 922 FSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEF 981
Query: 919 QKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKYREMMIVMRTTELV 978
L++ + KR AL +K + + ++EL +D +K I + TE
Sbjct: 982 DLLKKENEQRKRKLQAALINRKELLQRVSRLEEEL--ANLKDESKK----EIPLSETERG 1035
Query: 979 NKDLDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQDIEYIEIRSDADENVSASD 1038
+ D K + K + K +EI + + T +++E IR D +E ++A +
Sbjct: 1036 EVEEDKENKEYSE---KCVTSKCQEIEIYL----KQTISEKEVELQHIRKDLEEKLAAEE 1088
Query: 1039 K 1039
+
Sbjct: 1089 Q 1089
Score = 122 bits (307), Expect = 2e-27
Identities = 212/1098 (19%), Positives = 454/1098 (41%), Gaps = 186/1098 (16%)
Query: 58 QTQGQKVKEYQMELKYLKQYKEKAC-EIRDQITSKEAQLTS----SKEIVKSYE---NEL 109
Q+ + ++ L+ L + KEK EI +SK A+ T KE+ K YE
Sbjct: 1563 QSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSY 1622
Query: 110 DPLKNRLKEIEHNLSKI----MKLDNEIKALDSRKKQMEK-------DNSELEEKMEKVF 158
+ + N + I+H + + +L ++++ ++ KK+ EK + E++EKM K
Sbjct: 1623 ENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFA 1682
Query: 159 QGTDEQLNDLYHNHQR----------TVREKERKLVDCH----RELEKLNKESRLLNQEK 204
+ +++ +L + R T +E L+ + ELE++ E L+++
Sbjct: 1683 KSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKF 1742
Query: 205 SELLVEQGRLQLQADRHQEHIRARDSLIQSL--------ATQLELDGFERGPFSERQIKN 256
L+ E+ L + + I S +L T + +G + P + +
Sbjct: 1743 QSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDS 1802
Query: 257 FHKLVR---ERQEGEAKTANQLMN-DFAEKETLKQ--KQIDEIRDKKTGLGRIIELKSEI 310
R AK+AN ++ DF+ + + +QID+++++ GL + E
Sbjct: 1803 LSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEF 1862
Query: 311 --------------LSKKQNELKNVKYEL-------QQLEGSSDRILELDQELIKAEREL 349
+S K ELK ++ E+ QQ++ R+ +L + + + +L
Sbjct: 1863 SQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDL 1922
Query: 350 SK------AEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLT 403
+ AE N ++ +V Q + L+ ++ L + + +L + + L
Sbjct: 1923 EERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEE------EKQQLV 1976
Query: 404 KDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELA 463
K+K + +IRK G + K+L++ L K +E+ Q + + ++++
Sbjct: 1977 KEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKIS 2036
Query: 464 SSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGA 523
+ E+ + E + E Q +D E + L + +E K +A LA
Sbjct: 2037 ALERTVKAL--EFVQTESQ--------------KDLEITKENLAQAVEHRKKAQAELA-- 2078
Query: 524 TAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKL-----KSTES 578
F L D V + + ELQ ++S+++ + L ++ E
Sbjct: 2079 -----SFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEK 2133
Query: 579 ELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGT 638
LK+K+ +++ L +R+ + L E+ I E++ L ++++Q+L+ +++ T L
Sbjct: 2134 HLKEKKNMQEK---LDALRREKVHL-EETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAA 2189
Query: 639 IMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQ-AAKLQGIDL--DRTVQQVNQEKQE 695
S + +R E K ERK + +K + I L D +Q +Q
Sbjct: 2190 FTKSMSSLQ------DDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQM 2243
Query: 696 KQH--KLDTVSSKIELNRKLIQDQ-QEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQT 752
H +L S++E ++++ + + Q ++Q + + L+ E ++ + L+ + L +
Sbjct: 2244 SIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSS 2303
Query: 753 VELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEK---------------------EELI 791
E+ L E+K K+Q++ L +LEK +++K E+L
Sbjct: 2304 ---QNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLE 2360
Query: 792 NKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSE- 850
S ++ +I K + I + E IQ + ++Q + E+ ++ LS+
Sbjct: 2361 TDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQE 2420
Query: 851 -------CEKHKEKINEDMRLMR--QDIDTQKIQERWLQDNL-----TLRKRNEEL---- 892
E++K+ +++ +LM + I + IQ++ D+ +L+ + +
Sbjct: 2421 EEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDY 2480
Query: 893 KEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKE 952
+++EE + E Q+ + + +E+ KL+E I ++ + + + E+I ++++
Sbjct: 2481 QQLEERHLSIILEKDQL-IQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYRED 2539
Query: 953 LRE-----------------PQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMK 995
L + Q ++ E KY ++ ++ +E N+DL + L +
Sbjct: 2540 LNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQD 2599
Query: 996 FHSMKMEEINKIIRDLWR 1013
S ++E + I L R
Sbjct: 2600 L-SKEIESLKVSISQLTR 2616
Score = 120 bits (300), Expect = 1e-26
Identities = 228/1133 (20%), Positives = 487/1133 (42%), Gaps = 190/1133 (16%)
Query: 31 KALKQKFDEIFSATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITS 90
++L+QK + S+ I LE LR+++ K+ E Q K + + +E + Q++
Sbjct: 1368 ESLQQKLE---SSQLQIAGLEHLRELQP----KLDELQ---KLISKKEEDVSYLSGQLSE 1417
Query: 91 KEAQLTSSK-------------------------EIVKSYENELDPLKNRLKEIEHNLSK 125
KEA LT + E +K + EL +K + +EI
Sbjct: 1418 KEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRA 1477
Query: 126 IMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVD 185
++ +++A +K+ K+N L+E++ + +GT E+L +++ + E ++
Sbjct: 1478 KQQIQRKLQAALISRKEALKENKSLQEEL-SLARGTIERLT-------KSLADVESQVSA 1529
Query: 186 CHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQ-----LE 240
++E + + LL +E+ +L+ E R L+ + ++ L E
Sbjct: 1530 QNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKE 1589
Query: 241 LDGFERGPFSE-RQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTG 299
++ + +E + + HK +++ E ++ + N+ AE+ Q ++ +R +K
Sbjct: 1590 IESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNE-AER---IQHVVEAVRQEKQE 1645
Query: 300 LGRIIELKSEILSKKQNE--LKNVKYELQQL--------EGSSDRILELDQELIKAEREL 349
L +L+S +KK+ E L+ + E++++ + +ILEL++E + E+
Sbjct: 1646 L--YGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEV 1703
Query: 350 ----------------SKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHH- 392
S A +E +KME +L + L L +E++ L H
Sbjct: 1704 HPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQI 1763
Query: 393 --------------------TTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFP 432
T + + + ++D + S+ + S P
Sbjct: 1764 EGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANP 1823
Query: 433 NKKQ---LEDWLHSKSKEINQTRDRLAKL------NKELASS-EQNKNHINNELKRKEEQ 482
+ D +++ ++I+Q ++R+A L NKE + + E KN + +++ K+ +
Sbjct: 1824 AVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGE 1883
Query: 483 LSSYEDKLFDV-CGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSC 541
L ++++ + +Q + +L R+ + E + +++ L + + QL + N S
Sbjct: 1884 LKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLE------ERLMNQLAELNGSI 1937
Query: 542 CPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSII 601
CQ V T+A+++ + + + K LK SEL+++ +Q ++
Sbjct: 1938 GNYCQDV--TDAQIKNELLESEMK------NLKKCVSELEEE-------------KQQLV 1976
Query: 602 DLKEKEIPELR----NKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIME 657
K K E+R K+Q ++ + E QE L ++ K C+
Sbjct: 1977 KEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCI------- 2029
Query: 658 RFQMELKDVER--KIAQQAAKLQGIDLDRTVQQVNQE-KQEKQHKLDTVSSKIELN---- 710
R+Q ++ +ER K + DL+ T + + Q + K+ + + S K+ L+
Sbjct: 2030 RYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQS 2089
Query: 711 --RKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRR-QQLEEQTVE----LSTEVQSLY 763
+++ D + + L+S +KS+ Q +L+RR +Q EE+ ++ + ++ +L
Sbjct: 2090 EAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALR 2149
Query: 764 REIKDAKEQVSPLETTLEKFQQEKEEL-INKKNTSNKIA-----QDKLNDIKEKV-KNIH 816
RE +E + ++ TL K +E ++L N +T ++A L D +++V
Sbjct: 2150 REKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAK 2209
Query: 817 GYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQD--IDTQKI 874
+ + + IQ K++ + KE + + QL + H E++ ++ + D I K
Sbjct: 2210 KWERKFSDAIQ-SKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKA 2268
Query: 875 Q-ERWLQDNL--TLRKRNEE-LKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKR 930
Q E LQ + TL+ N+E L ++EE R HL Q ++ +++SE + L++ + ++
Sbjct: 2269 QTEVQLQQKVCDTLQGENKELLSQLEETR--HLYHSSQNELAKLESELKSLKDQLTDLS- 2325
Query: 931 NHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLD 990
N QKG E II +E ++++ Y ++ ++ + + L +
Sbjct: 2326 NSLEKCKEQKGNLEGII----RQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKE 2381
Query: 991 QAIMKFHSMKMEEINKIIRDLWRSTYRGQDIEYIE--IRSDADENVSASDKRR 1041
Q I+ S K E I I +L + ++I+ +E + + +EN+ ++ +
Sbjct: 2382 QKIISLLSGKEEAIQVAIAELRQQ--HDKEIKELENLLSQEEEENIVLEEENK 2432
Score = 118 bits (295), Expect = 4e-26
Identities = 187/954 (19%), Positives = 404/954 (42%), Gaps = 119/954 (12%)
Query: 47 IKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYE 106
I LE +Q+ +++ Q E Q++ K + + E+ Q+ SS+ + E
Sbjct: 2254 ISRLEHDKQIWESKAQT--EVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLE 2311
Query: 107 NELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELE-EKMEKVFQGTDEQL 165
+EL LK++L ++ ++L K + ++ + R+++ + NS+ E++E Q + E
Sbjct: 2312 SELKSLKDQLTDLSNSLEKCKEQKGNLEGI-IRQQEADIQNSKFSYEQLETDLQASRELT 2370
Query: 166 NDLYHNHQRTVREKERKLV---------------DCHRELEKLNKE-SRLLNQEKSELLV 209
+ L+ + KE+K++ + ++ +K KE LL+QE+ E +V
Sbjct: 2371 SRLHEE----INMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIV 2426
Query: 210 EQGRLQLQADRHQEHIRARDSLI-QSLATQLELDGFERGPFS-----ERQIKNFHKLVRE 263
+ + D+ + + ++ +++ + +LD F + S +R + ++ +L E
Sbjct: 2427 LEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQL-EE 2485
Query: 264 RQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLG-RIIELKSEILSKKQ--NELKN 320
R +QL+ + A + +++I +R L +L +E++ ++ N++
Sbjct: 2486 RHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVIT 2545
Query: 321 VK--YELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRT 378
+K + Q LE + EL+ + K E +L ++E+ + E L+ +LQ EK DL +
Sbjct: 2546 IKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEAN--EDLRRSFNALQEEKQDLSKE 2603
Query: 379 LRKLDQEMEQLNHHTTTRTQMEMLTKDKAD---KDEQIRKIKSRHSD------------- 422
+ L + QL T + L A K+E++ ++ + S
Sbjct: 2604 IESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELV 2663
Query: 423 ----ELTSLLGYFPNK--KQLEDWLHSKSKEINQTR---DRLAKLNKELASSEQNKNHIN 473
E +G +K K+L+ H N+T +R+A+L ++L EQ +
Sbjct: 2664 CVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVT 2723
Query: 474 NELKRKEEQLSSYEDKLFDVCGSQDFESD-LDRLKEEIEKSSKQRAMLAGA-------TA 525
E K Q+ S+ + + S+D ++ LD LK + + S K+ A L A
Sbjct: 2724 KENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDA 2783
Query: 526 VYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEK 585
+ S+ + ++ +++ Q E + L S+L + ++++S + +
Sbjct: 2784 LLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQN 2843
Query: 586 RRDEMLGLVPMRQSIIDLKEKEIPELRN---KLQNVNRDIQRLKNDIEEQETLLGTIMPE 642
RD + + + + K++ + ++Q++ + + L+ND ++ LL +
Sbjct: 2844 ERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQND---RDRLLKELKNL 2900
Query: 643 EESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDT 702
++ ++T + + +L++ + K +A ++ + ++Q N Q + H+L
Sbjct: 2901 QQQYLQINQEITELHPLKAQLQEYQDKT--KAFQI----MQEELRQENLSWQHELHQLRM 2954
Query: 703 VSSKIELNRK--------LIQDQQEQIQHLKSTTNELKSEKLQ---ISTNLQRR------ 745
S E++ + I D+ +Q+ HL++ EL+S Q + QR+
Sbjct: 2955 EKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETS 3014
Query: 746 ------QQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNK 799
Q L +T L T++ +EI + ++ L + + +EK L
Sbjct: 3015 ASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTL--------- 3065
Query: 800 IAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKIN 859
+L D + ++ + D+ N+ + ++ + LN +A + EK+
Sbjct: 3066 --SIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRK 3123
Query: 860 EDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQ 913
D +R+ Q E Q T ++ NE K +EEER Q + + V +
Sbjct: 3124 SDPEELRE--PQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAE 3175
Score = 108 bits (270), Expect = 3e-23
Identities = 206/975 (21%), Positives = 416/975 (42%), Gaps = 142/975 (14%)
Query: 52 TLRQVRQTQGQ--KVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENEL 109
TLR +T+ + K+ +MEL+ ++ K +++++ Q + + E+
Sbjct: 305 TLRNTVETEREESKILLEKMELEVAER-KLSFHNLQEEMHHLLEQFEQAGQAQAELESRY 363
Query: 110 DPLKNRLK-EIEHNLSKIMKLDNEIKALDSRKKQMEKDNSEL-EEKMEKVFQG--TDEQL 165
L+ + K E+E S I+ L + L S ++ NS+L ++K E+ Q T +QL
Sbjct: 364 SALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQL 423
Query: 166 NDLYHNHQRTVRE-------------KERKLVDCHRELEKLNKESRLLNQEKS--ELLVE 210
D + + + + D + E + E + + +K EL E
Sbjct: 424 EDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENE 483
Query: 211 QGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKL-VRERQEGEA 269
+G L L + +E ++A + + S T LE R ++R++ + + ++ A
Sbjct: 484 KGALLLSSIELEE-LKAENEKLSSQITLLEAQN--RTGEADREVSEISIVDIANKRSSSA 540
Query: 270 KTANQ--LMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQ 327
+ + Q L N F++K K++ + ++E+K + Q E+ +K +LQ
Sbjct: 541 EESGQDVLENTFSQKH----KELSVL---------LLEMK-----EAQEEIAFLKLQLQ- 581
Query: 328 LEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADL------DRTLRK 381
R E D E++ ++E+ + E + +KM+V L++ D + +L
Sbjct: 582 ----GKRAEEADHEVLD-QKEMKQME-GEGIAPIKMKVF-LEDTGQDFPLMPNEESSLPA 634
Query: 382 LDQEMEQLNHHTTTRTQMEM--------LTKDKADKD-EQIRKIKSRHSDELTSL----- 427
+++E H + T ++ + TK DK + I H DEL L
Sbjct: 635 VEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQIL 694
Query: 428 ---LGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLS 484
L + ++ E L K+KEI+ L +L +E + N + L + +QL
Sbjct: 695 ELELNFHKAQEIYEKNLDEKAKEISN----LNQLIEEFKKNADNNSSAFTALSEERDQLL 750
Query: 485 SYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQ----LTDENQS 540
S +L V + + + +L+ + ++ +QR + + + +T+ L+ E +S
Sbjct: 751 SQVKELSMVT---ELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKS 807
Query: 541 CCPVCQRVFQTEAE-LQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQS 599
V V Q E + +Q S+ + +R +L++ ESE+ + +R + V
Sbjct: 808 K-DVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQ 866
Query: 600 IIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERF 659
+ KE EI ++ L RD++ L+ IEE++ + I V L + E+F
Sbjct: 867 ALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNE----EKF 922
Query: 660 QM--ELKDVERKI----AQQAAKLQGIDLDRTVQQVNQE------------KQEKQHKLD 701
+ E+K ++ ++ + AK + ++ D V ++ K+E QH+ D
Sbjct: 923 SLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFD 982
Query: 702 TVSSKIELNRKLIQ----DQQEQIQHLKSTTNELKS----EKLQISTNLQRRQQLEE--Q 751
+ + E ++ +Q +++E +Q + EL + K +I + R ++EE +
Sbjct: 983 LLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKE 1042
Query: 752 TVELSTE-VQSLYREIK-DAKEQVSPLETTLEKFQQEKEELINKK-------NTSNKIAQ 802
E S + V S +EI+ K+ +S E L+ +++ EE + + N+ Q
Sbjct: 1043 NKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQ 1102
Query: 803 DKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKE--KINE 860
DK N I I I+ I D + + + C E K
Sbjct: 1103 DKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPEL 1162
Query: 861 DMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQK 920
+ +++ + + +++Q++ LQ+ LT RK + + +E+++HL+E ++ Q K ++ +
Sbjct: 1163 EEKILALEKEKEQLQKK-LQEALTSRK---AILKKAQEKERHLRE----ELKQQKDDYNR 1214
Query: 921 LEENID-NIKRNHNL 934
L+E D K N N+
Sbjct: 1215 LQEQFDEQSKENENI 1229
Score = 102 bits (255), Expect = 2e-21
Identities = 196/1108 (17%), Positives = 469/1108 (42%), Gaps = 157/1108 (14%)
Query: 31 KALKQKFDEIFSATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITS 90
+ L+ + D++ ++ + +R ++ K E + ++ K E+ ++
Sbjct: 813 EVLQNELDDV--QLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQ 870
Query: 91 KEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKI---------------MKLDNEIKA 135
KE ++T +++ + +++ L+ ++E + +++I L EIK
Sbjct: 871 KELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKT 930
Query: 136 L-----------DSRKKQMEKDN---SELEEKMEKVFQGTDEQLNDLYHNHQRTVREKER 181
L +++K+Q+E+DN S L++ +++ +L H +E E+
Sbjct: 931 LKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQ 990
Query: 182 K-------LVDCHRELEKLNK-ESRLLN---QEKSEL-LVEQGRLQLQADRHQEHIRARD 229
+ L++ L+++++ E L N + K E+ L E R +++ D+ E+ +
Sbjct: 991 RKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDK--ENKEYSE 1048
Query: 230 SLIQSLATQLELDGFERGPFSERQIKNFH-------KLVRERQ-EGEAKTANQLMND--- 278
+ S ++E+ + + SE++++ H KL E Q + K NQ + D
Sbjct: 1049 KCVTSKCQEIEI--YLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTN 1106
Query: 279 --------FAEKETLKQKQIDEIRDKKTGLGRII--------------------ELKSEI 310
+E + + QK I D G + EL+ +I
Sbjct: 1107 QIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKI 1166
Query: 311 LSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQN 370
L+ ++ E + ++ +LQ+ S IL+ QE + RE K +K+ + L+ +
Sbjct: 1167 LALEK-EKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKD-DYNRLQEQFDEQSK 1224
Query: 371 EKADLDRTLRKLD-QEMEQLNHHTTTRTQMEMLTKD--------KADKDEQIRKIKSR-- 419
E ++ LR+L Q E ++ + Q E + KA + + +
Sbjct: 1225 ENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNL 1284
Query: 420 ------HSDELTSLLG-------------YFPNKKQLE-------DWLHSKSKEINQTRD 453
HS++ ++L G K +LE L KS+E+ Q ++
Sbjct: 1285 CPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQE 1344
Query: 454 RLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKS 513
++ K E+ S + + + +++L S + ++ + ++ + LD L++ I K
Sbjct: 1345 QINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKK 1404
Query: 514 SKQRAMLAGAT----AVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLA 569
+ + L+G A ++ T++ ++ + ++ E E I LQ +L
Sbjct: 1405 EEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEM 1464
Query: 570 PDKLKSTESELKKKEK-RRDEMLGLVPMRQSIIDLK--EKEIPELRNKLQNVNRDIQRLK 626
K + E + K++ +R L+ ++++ + K ++E+ R ++ + + + ++
Sbjct: 1465 KQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVE 1524
Query: 627 NDI----EEQETLLGTI-MPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGID 681
+ + +E++T+LG + + +EE K+ +T M+R +E + + L+G+
Sbjct: 1525 SQVSAQNKEKDTVLGRLALLQEERDKL----ITEMDRSLLENQSLSSSCESLKLALEGLT 1580
Query: 682 LDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTN 741
D+ + V + + K K+ + E +++L ++ + +Q ++ +NE + + +
Sbjct: 1581 EDKE-KLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAV 1639
Query: 742 LQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIA 801
Q +Q+L + + +++++A++++ ++ + KF + K++ I + N
Sbjct: 1640 RQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRL 1699
Query: 802 QDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINED 861
+ +++ + K + +++ + K + ET K + +SE K+ ++E+
Sbjct: 1700 RAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSE----KDSLSEE 1755
Query: 862 MRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKL 921
++ ++ I+ + Q NL ++++ V EE Q + + Q S
Sbjct: 1756 VQDLKHQIEGNVSK----QANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTC 1811
Query: 922 EENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRDA--EEKYREMMIVMRTTELVN 979
E++ + K + N A+ + +EI ++ +++ + + R A EE+ ++ +T E
Sbjct: 1812 SESVPSAK-SANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEK 1870
Query: 980 KDLDIYYKTLDQAIMKFHSMKMEEINKI 1007
L T D + M EE+ K+
Sbjct: 1871 NTLLSQISTKDGEL----KMLQEEVTKM 1894
Score = 102 bits (255), Expect = 2e-21
Identities = 187/981 (19%), Positives = 403/981 (41%), Gaps = 133/981 (13%)
Query: 54 RQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLK 113
R++ Q + + +KE + + L + + + + I + L + V+ + LD
Sbjct: 2125 RRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTV 2184
Query: 114 NRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDE---------- 163
+L ++S + D+ + +D KK K + ++ K E++ D
Sbjct: 2185 TQLAAFTKSMSSLQ--DDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQ 2242
Query: 164 ---QLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADR 220
+ +L N R +K+ E++ K L E ELL QL+ R
Sbjct: 2243 MSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLS-----QLEETR 2297
Query: 221 H-----QEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQ---EGEAKTA 272
H Q + +S ++SL QL D + Q N ++R+++ + +
Sbjct: 2298 HLYHSSQNELAKLESELKSLKDQLT-DLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSY 2356
Query: 273 NQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVK-YELQQLEGS 331
QL D L + +EI K+ + ++ K E + EL+ E+++LE
Sbjct: 2357 EQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELE-- 2414
Query: 332 SDRILELDQELIKAERELSKAEKNSN--VETLKMEVISLQNEKADLDRTLRKLDQ----- 384
+ + + ++E I E E KA +N +ETLK +KA LD ++ +
Sbjct: 2415 -NLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDR 2473
Query: 385 -----EMEQLNH-HTTTRTQMEMLTKDKADKD----EQIRKIKSRHSDELTSLLGYFPNK 434
+ +QL H + + + L ++ A ++ E+IR ++S H D+L S
Sbjct: 2474 DRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRS-HMDDLNS------EN 2526
Query: 435 KQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKN-HINNELKRKEEQLSSYEDKLFDV 493
+L+ L +++NQ K+L + +N + N+ + EE+L E+ D+
Sbjct: 2527 AKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDL 2586
Query: 494 CGS--------QDFESDLDRLKEEIEKSSKQRAMLA--GATAVYSQFITQLTDENQSCCP 543
S QD +++ LK I + ++Q L G +Y + +E
Sbjct: 2587 RRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSA 2646
Query: 544 VC----QRVFQTEAELQEVISDLQSKLRLAPDKLKST-----------ESELKKKEKRRD 588
+ +R+ + E EL V + K+ DKLK +E + E+R
Sbjct: 2647 LFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVA 2706
Query: 589 EML-GLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAK 647
E+ LV M Q ++ + KE L ++Q+ R + L+N + L + + +++
Sbjct: 2707 ELARDLVEMEQKLL-MVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDAS- 2764
Query: 648 VCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRT--VQQVNQEKQEKQHKLDTVSS 705
L ++ ++ + ++ + +++ A + + + ++++NQ+ K +L +SS
Sbjct: 2765 --LKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSS 2822
Query: 706 KIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYRE 765
++E + +Q + + L++ + L +E + + + +Q+ Q EVQSL
Sbjct: 2823 QLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSL--- 2879
Query: 766 IKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENY 825
K+ +S L+ ++ +E + L Q + I +++ +H ++ Y
Sbjct: 2880 ----KKAMSSLQNDRDRLLKELKNL-----------QQQYLQINQEITELHPLKAQLQEY 2924
Query: 826 IQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDN--L 883
Q +T+ +++ + E + ++ +R + + +I ER +++ +
Sbjct: 2925 ----------QDKTKAFQIMQE--ELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLM 2972
Query: 884 TLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYE 943
+ ++++L ++ ++ Q Q L+++ + Q E + + NL YE
Sbjct: 2973 AISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLV------YE 3026
Query: 944 EEIIHFK-----KELREPQFR 959
E++ + KE+ + + R
Sbjct: 3027 TELLRTQLNDSLKEIHQKELR 3047
Score = 102 bits (254), Expect = 2e-21
Identities = 222/1081 (20%), Positives = 438/1081 (40%), Gaps = 183/1081 (16%)
Query: 52 TLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDP 111
T Q R ++ + + +ELK KQ +K+ L++ +I + +++EL+
Sbjct: 642 TEHQSRTSEEISLNDAGVELKSTKQDGDKS-------------LSAVPDIGQCHQDELER 688
Query: 112 LKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEE------KMEKVFQGTDEQL 165
LK+++ E+E N K ++ K LD + K++ N +EE F E+
Sbjct: 689 LKSQILELELNFHKAQEIYE--KNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEER 746
Query: 166 NDLYHNHQRT---------VREKERKLVDCHRELEKLNKESR-----LLNQEKSELLVEQ 211
+ L + V++ E L + R+ +L+ ES+ LL ++ L +E
Sbjct: 747 DQLLSQVKELSMVTELRAQVKQLEMNLAEAERQ-RRLDYESQTAHDNLLTEQIHSLSIEA 805
Query: 212 GR-------LQLQADRHQEHIRARDSLIQSLATQLE------LDGFERGPFSERQIKNFH 258
LQ + D Q + +LI+SL +QL+ L+G ER +++
Sbjct: 806 KSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELS 865
Query: 259 KLVRERQEGEAKTANQLMNDFAEKETLKQ------KQIDEIRDKKTGLGRIIELKSEILS 312
+ + +++ K L+ + ETL+Q +Q+ EI T ++++L E S
Sbjct: 866 QALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTE--KMVQLNEEKFS 923
Query: 313 KKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEK 372
E+K +K +L L R E +E ++ + E+S K + E IS + +
Sbjct: 924 LGV-EIKTLKEQLNLLS----RAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQ 978
Query: 373 ADLDRTLRKLDQEMEQLNHHTTTRTQM----EMLTKDKADKDEQIRKIKSRHSDELTSLL 428
+ D ++ +Q +L R ++ L ++ A+ ++ +K E +
Sbjct: 979 HEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVE 1038
Query: 429 GYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRK---EEQLSS 485
NK+ E + SK +EI L + ++ E HI +L+ K EEQ +
Sbjct: 1039 EDKENKEYSEKCVTSKCQEIE------IYLKQTISEKEVELQHIRKDLEEKLAAEEQFQA 1092
Query: 486 YEDKLFDVCGSQDFESDLDRLKEEI-EKSSKQRAMLAGATAVYSQFITQLTDENQSCCPV 544
++ QD + +D L+ EI E + + ++ T L E P
Sbjct: 1093 LVKQMNQTL--QDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPP 1150
Query: 545 CQRVFQT-EAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDL 603
C + + EL+E I L+ K+KE+ + ++ + R++I+
Sbjct: 1151 CTGSSEHWKPELEEKILALE-----------------KEKEQLQKKLQEALTSRKAILKK 1193
Query: 604 KEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMEL 663
+++ LR +L+ D RL+ +EQ E E+ L + I R ++
Sbjct: 1194 AQEKERHLREELKQQKDDYNRLQEQFDEQSK-------ENENIGDQLRQLQIQVRESIDG 1246
Query: 664 KDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQD---QQEQ 720
K + + G++ K +QH V L L D E
Sbjct: 1247 KLPSTDQQESCSSTPGLEEPLF-------KATEQHHTQPV-----LESNLCPDWPSHSED 1294
Query: 721 IQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTL 780
L+ T+ QI L+ ++E + VEL +V S E+ E+V L+ +
Sbjct: 1295 ASALQGGTSVA-----QIKAQLK---EIEAEKVELELKVSSTTSELTKKSEEVFQLQEQI 1346
Query: 781 EKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENY--IQDGKDDYKK--- 835
K E E L T + A+ +++K+++ + +E+ +Q D+ +K
Sbjct: 1347 NKQGLEIESL----KTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLIS 1402
Query: 836 QKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEV 895
+KE +++ + QLSE E KI ++ + ++D+ I+ Q + ++ +E +K++
Sbjct: 1403 KKEEDVSYLSGQLSEKEAALTKIQTEI-IEQEDL----IKALHTQLEMQAKEHDERIKQL 1457
Query: 896 EE---ERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEE------- 945
+ E KQ +E+G + Q+++ + + AL K +EE
Sbjct: 1458 QVELCEMKQKPEEIG-----EESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGT 1512
Query: 946 IIHFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMK----- 1000
I K L + + + + + +E V+ L+ ++ D +D+++++ S+
Sbjct: 1513 IERLTKSLADVESQVSAQN-KEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCES 1571
Query: 1001 --------MEEINKIIRDL-------------WRSTYRGQDIEYIEIRSDADENVSASDK 1039
E+ K+++++ W+ ++ EY EI + ENVS +
Sbjct: 1572 LKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEY-EILLQSYENVSNEAE 1630
Query: 1040 R 1040
R
Sbjct: 1631 R 1631
Score = 70.9 bits (172), Expect = 7e-12
Identities = 112/518 (21%), Positives = 221/518 (42%), Gaps = 69/518 (13%)
Query: 20 QEDSNWPLSEGKALKQKFDEIFSATRYIKALETLRQVRQTQGQ-KVKEYQMEL--KYLKQ 76
QE+ E ++LK ++ TR + AL+ + Q KVKE ++
Sbjct: 2594 QEEKQDLSKEIESLKVSISQL---TRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSS 2650
Query: 77 YKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKAL 136
+++ E+ +++ + KE K D LK LK + H+ IM+ NE +
Sbjct: 2651 SQKRIAELEEELVCVQ------KEAAKKVGEIEDKLKKELKHLHHDAG-IMR--NETETA 2701
Query: 137 DSRKKQMEKDNSELEEKMEKV----------FQGTDEQLNDLYHNHQRT---VREKERKL 183
+ R ++ +D E+E+K+ V Q ++ L ++ + E +RK
Sbjct: 2702 EERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKY 2761
Query: 184 VDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQ--------EHIRARDSLIQSL 235
+EL +L KE LLN+E+ LL E + + + + ++D + L
Sbjct: 2762 DASLKELAQL-KEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHL 2820
Query: 236 ATQLE-----LDGFERGPFS---ERQ-IKNFHKLVRERQEGEAKTANQLMNDFAEKETLK 286
++QLE + F + S ER + N + R+ +EG+ ++A Q AE ++LK
Sbjct: 2821 SSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLK 2880
Query: 287 QKQIDEIRDKKTGLGRIIELKSEILSKKQN--ELKNVKYELQQLEGSSDRILELDQELIK 344
+ D+ L + L+ + L Q EL +K +LQ+ + + + ++ QE ++
Sbjct: 2881 KAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKT-KAFQIMQEELR 2939
Query: 345 AERELSKAEKNSNVETLKMEVISLQ-NEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLT 403
E + E + L+ME S + +E+ ++ L + + +QL+H ++ L
Sbjct: 2940 QENLSWQHE----LHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSH-------LQNLI 2988
Query: 404 KDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQ--------LEDWLHSKSKEINQTRDRL 455
++ Q + +K ++ + + P+ Q L L+ KEI+Q R+
Sbjct: 2989 RELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRI 3048
Query: 456 AKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDV 493
+LN + + KN ++ +L + L + D+
Sbjct: 3049 QQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDL 3086
Score = 60.1 bits (144), Expect = 1e-08
Identities = 90/465 (19%), Positives = 189/465 (40%), Gaps = 78/465 (16%)
Query: 705 SKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQ-LEEQTVELSTEVQSLY 763
S +E N +D QE++ + + ELK Q LQ++ + L+E+ +++ L
Sbjct: 38 SDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLK 97
Query: 764 REIKDAKEQVSPLETTLEKF----------QQEKEELINKKNTSNKIAQDKLNDIKEKVK 813
AK +++ L +E+ + + EE ++K + S+ + ++ IK K++
Sbjct: 98 LH---AKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQ 154
Query: 814 NIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKIN----EDMRLMRQDI 869
+ ++ + + + Q TE+ + + + ++ +E I+ + + +
Sbjct: 155 EKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQA 214
Query: 870 DTQKIQERWLQDNLTLRKRNEEL------KEVEEERKQHLKEM------------GQMQV 911
Q ++E+ + +R +EL +VE E +Q L+ + G+ QV
Sbjct: 215 AQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQV 274
Query: 912 LQM--------KSEHQKLEENIDNIKRNHNLALGRQKGYEEE--IIHFKKEL----REPQ 957
+ + + +Q L + + ++ HN + EE I+ K EL R+
Sbjct: 275 VDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLS 334
Query: 958 FRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYR 1017
F + +E+ ++ +L+ Y L+Q H +MEE I L ++
Sbjct: 335 FHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQK----HKAEMEEKTSHILSLQKT--- 387
Query: 1018 GQDIEYIEIRSDADENVSASDKRRNYNYRVVMLKGDTAL-------DMRGRCSAGQKVLA 1070
GQ+++ SA D ++ N +++ K + A+ + + K ++
Sbjct: 388 GQELQ------------SACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEIS 435
Query: 1071 SLIIRLALA--ETFCLNCGIIALDEPTTNLDRENIESLAHALVEI 1113
+ RL L ET +E T + ENI SL +VE+
Sbjct: 436 QFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVEL 480
Score = 56.6 bits (135), Expect = 1e-07
Identities = 96/483 (19%), Positives = 200/483 (41%), Gaps = 74/483 (15%)
Query: 39 EIFSATRYIKALETLRQVRQTQGQKVK-EYQMELKYLKQYKEKAC--EIRDQITSKEA-Q 94
+I S R + +L+ R + ++K +Y LK L Q KE+ RD + S+ A
Sbjct: 2732 QIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFS 2791
Query: 95 LTSSKEIVKSYENELDP-LKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEK 153
+ S++E S+ +L+ L ++ +++ H S++ N++++ ++ + L +
Sbjct: 2792 MNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNE 2851
Query: 154 MEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGR 213
+EK F+ ++E QR+ + E++ L K L ++ LL E
Sbjct: 2852 LEK-FRKSEE-------GKQRSAAQPSTSPA----EVQSLKKAMSSLQNDRDRLLKELKN 2899
Query: 214 LQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTAN 273
LQ Q++++ + + + +L ++ + K F + E ++ +
Sbjct: 2900 LQ------QQYLQINQEITELHPLKAQLQEYQD------KTKAFQIMQEELRQENLSWQH 2947
Query: 274 QLMNDFAEKET-------LKQKQIDEIRDKKTGLGRIIELKSEILSKK-QNELKNVKYEL 325
+L EK + +K++ + I DK L + L E+ S Q + V+Y+
Sbjct: 2948 ELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQR 3007
Query: 326 QQLEGSS-----DRILELDQELIKAE----------RELSKAEKNSNVETLKMEVISLQN 370
Q +S + L + EL++ + +EL + NSN L E +L
Sbjct: 3008 QASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSI 3067
Query: 371 EKADLDRTLRKLDQEM-EQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLG 429
+ D ++LR+ Q + LNH Q++ L + D
Sbjct: 3068 QLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNID------------------- 3108
Query: 430 YFPNKKQLEDWLHSKS--KEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYE 487
P Q ++ +H KS +E+ + + ++ ++L ++ Q N + L+ + +Q + E
Sbjct: 3109 VAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAE 3168
Query: 488 DKL 490
+ L
Sbjct: 3169 NAL 3171
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 143 bits (360), Expect = 1e-33
Identities = 212/1057 (20%), Positives = 459/1057 (43%), Gaps = 163/1057 (15%)
Query: 46 YIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSY 105
+ K L+ RQ + + KE EL+ K+ ++KA ++ K +QLT K +++
Sbjct: 838 FTKVKPLLQVTRQEEEMQAKED--ELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 895
Query: 106 ---ENE-----------LDPLKNRLKEIEHNL-SKIMKLDNEIKALDSRKKQMEKDNSEL 150
E E L K L+EI H + +++ + ++ + L + +K+M + +L
Sbjct: 896 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 955
Query: 151 EEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVE 210
EE++E+ + ++L + +++ E +++ + KL+KE +LL + S+L
Sbjct: 956 EEQLEEE-EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1014
Query: 211 QGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAK 270
+ +A + +S+I L +L+ + E+ + KL R + EG+A
Sbjct: 1015 LAEEEEKAKNLTKLKNKHESMISELEVRLKKE--------EKSRQELEKLKR-KLEGDA- 1064
Query: 271 TANQLMNDFAEKETLKQKQIDEIR----DKKTGLGRIIELKSEILSKKQNELKNVKYELQ 326
+DF E+ Q QI E++ K+ L + + +++K N LK ++
Sbjct: 1065 ------SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR---- 1114
Query: 327 QLEGS-SDRILELDQE-LIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQ 384
+LEG SD +LD E + + E K + +E LK E+ + A K +Q
Sbjct: 1115 ELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQ 1174
Query: 385 EMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSK 444
E+ L + L ++ + Q+++++ +H+ + L +QLE + +K
Sbjct: 1175 EVTVLK---------KALDEETRSHEAQVQEMRQKHAQAVEEL------TEQLEQFKRAK 1219
Query: 445 SKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLD 504
+ +++ + L K N +LA + E++ K+++L + +L C SD +
Sbjct: 1220 A-NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKC------SDGE 1272
Query: 505 RLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQS 564
R + E+ + +L +E +S + +L + ++ L S
Sbjct: 1273 RARAELNDK-----------------VHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1315
Query: 565 KLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQR 624
+L+ D + + E ++K ++ L R S+ D ++E+ +N ++++ +
Sbjct: 1316 QLQ---DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1372
Query: 625 LKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDR 684
L + ++ + T+ EE K RFQ E++++ ++ ++AA
Sbjct: 1373 LSDSKKKLQDFASTVEALEEGKK----------RFQKEIENLTQQYEEKAA--------- 1413
Query: 685 TVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTN-LQ 743
++ + K Q +LD + ++ R+L+ + +++ + ++L +E+ IS+
Sbjct: 1414 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK----QRKFDQLLAEEKNISSKYAD 1469
Query: 744 RRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQD 803
R + E + E T+ SL R +++A E LE T + + E E+L++ K+
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKD-------- 1521
Query: 804 KLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMR 863
+ KN+H K K+ ET++ ++ QL E E + ED +
Sbjct: 1522 ------DVGKNVHELEKS------------KRALETQMEEMKTQLEELEDELQ-ATEDAK 1562
Query: 864 LMRQDIDTQKIQERWLQDNLTLRKRNEELK------------EVEEERKQHLKEMGQMQV 911
L R +++ Q ++ ++ +D ++NEE + E+E+ERKQ + +
Sbjct: 1563 L-RLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ--RALAAAAK 1619
Query: 912 LQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKEL------REPQFRDAEEKY 965
+++ + + LE D+ + A+ + + + ++ F++EL R+ F A+E
Sbjct: 1620 KKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE 1679
Query: 966 REMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKII-RDLWRSTYRGQDIEYI 1024
++ + + +DL + QA ++ + E + + R+ + R +
Sbjct: 1680 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1739
Query: 1025 EIRSDADE---NVSA-SDKRRNYNYRVVMLKGDTALD 1057
++ + +E N+ A SD+ R + L + A +
Sbjct: 1740 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1776
Score = 120 bits (300), Expect = 1e-26
Identities = 191/876 (21%), Positives = 366/876 (41%), Gaps = 146/876 (16%)
Query: 29 EGKALKQKFDEIFSATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQI 88
E LK+ DE TR +A ++++RQ Q V+E +L+ K+ K + + +
Sbjct: 1175 EVTVLKKALDE---ETRSHEA--QVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1229
Query: 89 TSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNS 148
+ A L EL L +E+EH K KL+ +++ L S+ E+ +
Sbjct: 1230 EKENADLAG----------ELRVLGQAKQEVEH---KKKKLEAQVQELQSKCSDGERARA 1276
Query: 149 ELEEKMEKVFQGTDEQLNDLYHNHQ-------RTVREKERKLVDCHRELEKLNKESRLLN 201
EL +K+ K+ Q E + + + + + V +L D L++ ++ ++
Sbjct: 1277 ELNDKVHKL-QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVS 1335
Query: 202 QEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLV 261
+ +L E+ LQ Q D E + + I +L QL S++++++F V
Sbjct: 1336 TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS--------DSKKKLQDFASTV 1387
Query: 262 RERQEGEAKTANQLMN---DFAEK-------ETLKQKQIDEIRDKKTGLGRIIELKSEIL 311
+EG+ + ++ N + EK E K + E+ D L +L S L
Sbjct: 1388 EALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN-L 1446
Query: 312 SKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNE 371
KKQ + + E + + + E +AE E EK + +L +
Sbjct: 1447 EKKQRKFDQLLAEEKNISS------KYADERDRAEAEAR--EKETKALSLARALEEALEA 1498
Query: 372 KADLDRTLRKLDQEMEQL-NHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGY 430
K +L+RT + L EME L + + L K K + Q+ ++K++
Sbjct: 1499 KEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ----------- 1547
Query: 431 FPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKL 490
++LED E+ T D AKL E+ + + K +L+ ++EQ E+K
Sbjct: 1548 ---LEELED-------ELQATED--AKLRLEV-NMQALKGQFERDLQARDEQ---NEEK- 1590
Query: 491 FDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQ 550
+ + L + E+E KQRA+ A A + L + S + +
Sbjct: 1591 -----RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK 1645
Query: 551 TEAELQEVISDLQSKL---RLAPDKLKSTESELKKKEKRRD-------EMLGLVPMRQSI 600
+LQ + D Q +L R + D++ +T E +KK K + E L +
Sbjct: 1646 QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQ 1705
Query: 601 IDLKEKEIPEL-------RNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDV 653
DL+++E+ E RN LQ+ R ++ +EE+ + EE+ ++D
Sbjct: 1706 ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE-------LEEEQGNMEAMSDR 1758
Query: 654 TIMERFQMELKDVERKIAQQAAKLQGIDLDRT-VQQVNQEKQEKQHKLD-TVSSKIE--- 708
+ + + + + ++A + + Q + R +++ N+E + K H+++ V SK +
Sbjct: 1759 --VRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1816
Query: 709 --LNRKLIQ----------DQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELS 756
L K+ Q ++Q + LK +LK LQ+ + +Q +EQ + +
Sbjct: 1817 AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN 1876
Query: 757 TEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIH 816
V+ L R++++A+E+ + K Q+E +E SN+ ++N +K K++ +
Sbjct: 1877 ARVKQLKRQLEEAEEESQRINANRRKLQRELDE----ATESNEAMGREVNALKSKLRRGN 1932
Query: 817 ----------GYMKDIENYIQDGKDDYKKQKETELN 842
G + IEN DG ++ ++ + N
Sbjct: 1933 ETSFVPSRRSGGRRVIEN--ADGSEEETDTRDADFN 1966
Score = 51.2 bits (121), Expect = 6e-06
Identities = 64/361 (17%), Positives = 151/361 (41%), Gaps = 28/361 (7%)
Query: 717 QQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPL 776
Q+E++Q + + K + + L+ +Q Q E +Q + + + +
Sbjct: 850 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 909
Query: 777 ETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQ 836
L +QE EE++++ + +D+ ++ + K + M D+E +++ ++ +Q
Sbjct: 910 RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE--EEAARQ 967
Query: 837 KETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVE 896
K +L KV A+ + E + D + + + + ++ER L + E+ K +
Sbjct: 968 K-LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1026
Query: 897 EERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREP 956
+ + +H + +++V K E K + ++ +KR G + E+I + ++ E
Sbjct: 1027 KLKNKHESMISELEVRLKKEE--KSRQELEKLKRKLE---GDASDFHEQIADLQAQIAEL 1081
Query: 957 QFRDAEEKYREMMIVMRTTELVN---------KDLDIYYKTLDQAIMKFHSMKMEEINKI 1007
+ + A+++ + R + + ++L+ + L + + + + + K
Sbjct: 1082 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR-NKAEKQ 1140
Query: 1008 IRDLWRSTYRGQDIEYI--EIRSDADENVSASDKRRNYNYRVVMLKGDTALDMRGRCSAG 1065
RDL G+++E + E+ D + + R V +LK ALD R
Sbjct: 1141 KRDL------GEELEALKTELEDTLDSTATQQELRAKREQEVTVLK--KALDEETRSHEA 1192
Query: 1066 Q 1066
Q
Sbjct: 1193 Q 1193
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 143 bits (360), Expect = 1e-33
Identities = 212/1057 (20%), Positives = 459/1057 (43%), Gaps = 163/1057 (15%)
Query: 46 YIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSY 105
+ K L+ RQ + + KE EL+ K+ ++KA ++ K +QLT K +++
Sbjct: 845 FTKVKPLLQVTRQEEEMQAKED--ELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 902
Query: 106 ---ENE-----------LDPLKNRLKEIEHNL-SKIMKLDNEIKALDSRKKQMEKDNSEL 150
E E L K L+EI H + +++ + ++ + L + +K+M + +L
Sbjct: 903 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 962
Query: 151 EEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVE 210
EE++E+ + ++L + +++ E +++ + KL+KE +LL + S+L
Sbjct: 963 EEQLEEE-EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1021
Query: 211 QGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAK 270
+ +A + +S+I L +L+ + E+ + KL R + EG+A
Sbjct: 1022 LAEEEEKAKNLTKLKNKHESMISELEVRLKKE--------EKSRQELEKLKR-KLEGDA- 1071
Query: 271 TANQLMNDFAEKETLKQKQIDEIR----DKKTGLGRIIELKSEILSKKQNELKNVKYELQ 326
+DF E+ Q QI E++ K+ L + + +++K N LK ++
Sbjct: 1072 ------SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR---- 1121
Query: 327 QLEGS-SDRILELDQE-LIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQ 384
+LEG SD +LD E + + E K + +E LK E+ + A K +Q
Sbjct: 1122 ELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQ 1181
Query: 385 EMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSK 444
E+ L + L ++ + Q+++++ +H+ + L +QLE + +K
Sbjct: 1182 EVTVLK---------KALDEETRSHEAQVQEMRQKHAQAVEEL------TEQLEQFKRAK 1226
Query: 445 SKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLD 504
+ +++ + L K N +LA + E++ K+++L + +L C SD +
Sbjct: 1227 A-NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKC------SDGE 1279
Query: 505 RLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQS 564
R + E+ + +L +E +S + +L + ++ L S
Sbjct: 1280 RARAELNDK-----------------VHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1322
Query: 565 KLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQR 624
+L+ D + + E ++K ++ L R S+ D ++E+ +N ++++ +
Sbjct: 1323 QLQ---DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379
Query: 625 LKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDR 684
L + ++ + T+ EE K RFQ E++++ ++ ++AA
Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKK----------RFQKEIENLTQQYEEKAA--------- 1420
Query: 685 TVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTN-LQ 743
++ + K Q +LD + ++ R+L+ + +++ + ++L +E+ IS+
Sbjct: 1421 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK----QRKFDQLLAEEKNISSKYAD 1476
Query: 744 RRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQD 803
R + E + E T+ SL R +++A E LE T + + E E+L++ K+
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKD-------- 1528
Query: 804 KLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMR 863
+ KN+H K K+ ET++ ++ QL E E + ED +
Sbjct: 1529 ------DVGKNVHELEKS------------KRALETQMEEMKTQLEELEDELQ-ATEDAK 1569
Query: 864 LMRQDIDTQKIQERWLQDNLTLRKRNEELK------------EVEEERKQHLKEMGQMQV 911
L R +++ Q ++ ++ +D ++NEE + E+E+ERKQ + +
Sbjct: 1570 L-RLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ--RALAAAAK 1626
Query: 912 LQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKEL------REPQFRDAEEKY 965
+++ + + LE D+ + A+ + + + ++ F++EL R+ F A+E
Sbjct: 1627 KKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE 1686
Query: 966 REMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKII-RDLWRSTYRGQDIEYI 1024
++ + + +DL + QA ++ + E + + R+ + R +
Sbjct: 1687 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1746
Query: 1025 EIRSDADE---NVSA-SDKRRNYNYRVVMLKGDTALD 1057
++ + +E N+ A SD+ R + L + A +
Sbjct: 1747 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1783
Score = 120 bits (300), Expect = 1e-26
Identities = 191/876 (21%), Positives = 366/876 (41%), Gaps = 146/876 (16%)
Query: 29 EGKALKQKFDEIFSATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQI 88
E LK+ DE TR +A ++++RQ Q V+E +L+ K+ K + + +
Sbjct: 1182 EVTVLKKALDE---ETRSHEA--QVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1236
Query: 89 TSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNS 148
+ A L EL L +E+EH K KL+ +++ L S+ E+ +
Sbjct: 1237 EKENADLAG----------ELRVLGQAKQEVEH---KKKKLEAQVQELQSKCSDGERARA 1283
Query: 149 ELEEKMEKVFQGTDEQLNDLYHNHQ-------RTVREKERKLVDCHRELEKLNKESRLLN 201
EL +K+ K+ Q E + + + + + V +L D L++ ++ ++
Sbjct: 1284 ELNDKVHKL-QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVS 1342
Query: 202 QEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLV 261
+ +L E+ LQ Q D E + + I +L QL S++++++F V
Sbjct: 1343 TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS--------DSKKKLQDFASTV 1394
Query: 262 RERQEGEAKTANQLMN---DFAEK-------ETLKQKQIDEIRDKKTGLGRIIELKSEIL 311
+EG+ + ++ N + EK E K + E+ D L +L S L
Sbjct: 1395 EALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN-L 1453
Query: 312 SKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNE 371
KKQ + + E + + + E +AE E EK + +L +
Sbjct: 1454 EKKQRKFDQLLAEEKNISS------KYADERDRAEAEAR--EKETKALSLARALEEALEA 1505
Query: 372 KADLDRTLRKLDQEMEQL-NHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGY 430
K +L+RT + L EME L + + L K K + Q+ ++K++
Sbjct: 1506 KEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ----------- 1554
Query: 431 FPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKL 490
++LED E+ T D AKL E+ + + K +L+ ++EQ E+K
Sbjct: 1555 ---LEELED-------ELQATED--AKLRLEV-NMQALKGQFERDLQARDEQ---NEEK- 1597
Query: 491 FDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQ 550
+ + L + E+E KQRA+ A A + L + S + +
Sbjct: 1598 -----RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK 1652
Query: 551 TEAELQEVISDLQSKL---RLAPDKLKSTESELKKKEKRRD-------EMLGLVPMRQSI 600
+LQ + D Q +L R + D++ +T E +KK K + E L +
Sbjct: 1653 QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQ 1712
Query: 601 IDLKEKEIPEL-------RNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDV 653
DL+++E+ E RN LQ+ R ++ +EE+ + EE+ ++D
Sbjct: 1713 ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE-------LEEEQGNMEAMSDR 1765
Query: 654 TIMERFQMELKDVERKIAQQAAKLQGIDLDRT-VQQVNQEKQEKQHKLD-TVSSKIE--- 708
+ + + + + ++A + + Q + R +++ N+E + K H+++ V SK +
Sbjct: 1766 --VRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1823
Query: 709 --LNRKLIQ----------DQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELS 756
L K+ Q ++Q + LK +LK LQ+ + +Q +EQ + +
Sbjct: 1824 AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN 1883
Query: 757 TEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIH 816
V+ L R++++A+E+ + K Q+E +E SN+ ++N +K K++ +
Sbjct: 1884 ARVKQLKRQLEEAEEESQRINANRRKLQRELDE----ATESNEAMGREVNALKSKLRRGN 1939
Query: 817 ----------GYMKDIENYIQDGKDDYKKQKETELN 842
G + IEN DG ++ ++ + N
Sbjct: 1940 ETSFVPSRRSGGRRVIEN--ADGSEEETDTRDADFN 1973
Score = 51.2 bits (121), Expect = 6e-06
Identities = 64/361 (17%), Positives = 151/361 (41%), Gaps = 28/361 (7%)
Query: 717 QQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPL 776
Q+E++Q + + K + + L+ +Q Q E +Q + + + +
Sbjct: 857 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM 916
Query: 777 ETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQ 836
L +QE EE++++ + +D+ ++ + K + M D+E +++ ++ +Q
Sbjct: 917 RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE--EEAARQ 974
Query: 837 KETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVE 896
K +L KV A+ + E + D + + + + ++ER L + E+ K +
Sbjct: 975 K-LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1033
Query: 897 EERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREP 956
+ + +H + +++V K E K + ++ +KR G + E+I + ++ E
Sbjct: 1034 KLKNKHESMISELEVRLKKEE--KSRQELEKLKRKLE---GDASDFHEQIADLQAQIAEL 1088
Query: 957 QFRDAEEKYREMMIVMRTTELVN---------KDLDIYYKTLDQAIMKFHSMKMEEINKI 1007
+ + A+++ + R + + ++L+ + L + + + + + K
Sbjct: 1089 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR-NKAEKQ 1147
Query: 1008 IRDLWRSTYRGQDIEYI--EIRSDADENVSASDKRRNYNYRVVMLKGDTALDMRGRCSAG 1065
RDL G+++E + E+ D + + R V +LK ALD R
Sbjct: 1148 KRDL------GEELEALKTELEDTLDSTATQQELRAKREQEVTVLK--KALDEETRSHEA 1199
Query: 1066 Q 1066
Q
Sbjct: 1200 Q 1200
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 138 bits (347), Expect = 4e-32
Identities = 217/1035 (20%), Positives = 448/1035 (43%), Gaps = 135/1035 (13%)
Query: 48 KALETLRQVRQTQGQKVKEYQMELKYLKQ-YKEKACEIRDQITSKEAQLTSSKEIVKSYE 106
K +++++Q + Q++ ++Q E+ L+ +++K EI + +E + YE
Sbjct: 213 KLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRR----------HREELSDYE 262
Query: 107 NELDPLKNRLKE-----IEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGT 161
++ L+N L++ IE +LSKI ++ I+ L K + K +LE+K++ +
Sbjct: 263 ERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDI---- 318
Query: 162 DEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRH 221
N + + E +R ++ RE E+LN E R + +E L +E +LQ A +
Sbjct: 319 ---------NKKLSSAENDRDIL--RREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQ 367
Query: 222 QEHIRARDSLIQSLATQLELDGFERG-PFSERQIKNFHKLVRERQEGEAKTANQLMNDFA 280
+ + ++ ++ A+ E+ ++ +E +I L ++ N A
Sbjct: 368 SDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQD-------------NSLA 414
Query: 281 EKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQ 340
E + LK K E+ +K+ L + + K E+ Q L + E + ++ ++ R + LD
Sbjct: 415 E-DNLKLKMRIEVLEKEKSL--LSQEKEEL----QMSLLKLNNEYEVIKSTATRDISLDS 467
Query: 341 EL--IKAERELSKAEKNSNV---ETL--KMEVISLQNEKADLDRTLRKLDQEMEQLNHHT 393
EL ++ E + E N ++ ETL ++E + QN++A L K DQ +Q N
Sbjct: 468 ELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIK-DQLSKQQNEGD 526
Query: 394 T-----------TRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLH 442
+ + ++ L DK D +++ K + +L K++LED +
Sbjct: 527 SIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVE 586
Query: 443 SKSKEINQTRDRLAKLNKE-------LASSEQNKNHINNELKR--KEEQLSSYEDKLF-- 491
+ ++N++++ + KE + +E+ + I NEL + ++ S+++D L
Sbjct: 587 NLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKE 646
Query: 492 ---DVCGSQDFESDLDRLKEEIEK-----SSKQRAMLAGATAVYSQFITQLTDENQSCCP 543
+V + S+L++L E ++K + ++ V Q L NQ
Sbjct: 647 REAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLE 706
Query: 544 VCQRVFQTEAELQEVISDL-QSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIID 602
V + E E+ ++L +K RL E K EK +E+ + S +
Sbjct: 707 KNTIVETLKMEKGEIEAELCWAKKRLL--------EEANKYEKTIEELSNARNLNTSALQ 758
Query: 603 LKEKEIPELRNK----LQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMER 658
L+ + + +L K + + ++I+++ D +E + +L + + E++ LT + +
Sbjct: 759 LEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQ----LTQLINKKE 814
Query: 659 FQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQE---KQEKQHKLDTVSSKIELNRKLIQ 715
+E K+ ++++KLQ +LD+ Q + + +Q + K ++ S E N L Q
Sbjct: 815 IFIE------KLKERSSKLQE-ELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHL-Q 866
Query: 716 DQQEQIQHLKSTTNELKSEK-LQISTNLQRR-QQLEEQTVELSTEVQSLYREIKDAKEQV 773
++ E+++ +S T + K L T L QL L E++ + I+D +
Sbjct: 867 EELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSK 926
Query: 774 SPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDY 833
L +L++ ++E +E + N + E++K++ ++ I+ + + + D
Sbjct: 927 MQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDI 986
Query: 834 KKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELK 893
+ + Q E EK D+ + + I+ER L+ L K K
Sbjct: 987 QTDNSDIFQETKVQSLNIENGSEK--HDLSKAETERLVKGIKERELEIKLLNEKNISLTK 1044
Query: 894 EVEEERKQHLKEMGQM-QVLQMKS-EHQKLEENIDNIKRNHNLALGRQK----GYEEEII 947
++++ K E+G++ Q++Q K E Q L I + ++ +Q+ E E +
Sbjct: 1045 QIDQLSKD---EVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKV 1101
Query: 948 HFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKI 1007
+ + + +Y +MM ++ E L K L +F S + +
Sbjct: 1102 FAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLS---TRFESSGQDMFRET 1158
Query: 1008 IRDLWRSTYRGQDIE 1022
I++L R R +DIE
Sbjct: 1159 IQNLSR-IIREKDIE 1172
Score = 116 bits (290), Expect = 1e-25
Identities = 159/789 (20%), Positives = 337/789 (42%), Gaps = 79/789 (10%)
Query: 64 VKEYQMELKYLKQYKEKACEIRDQITSKEA-QLTSSKEIVKSYENELDPLKNRLKEIEHN 122
+KE ++E+K L + + DQ++ E +LT +I++ + E+ L R+ H
Sbjct: 1025 IKERELEIKLLNEKNISLTKQIDQLSKDEVGKLT---QIIQQKDLEIQALHARISSTSHT 1081
Query: 123 LSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERK 182
++ L +++A + EK + L EK + + L YH V KE
Sbjct: 1082 -QDVVYLQQQLQAYAMER---EKVFAVLNEKTRE-----NSHLKTEYHKMMDIVAAKEAA 1132
Query: 183 LVDCHRELEKLNKESRLLNQEK-SELLVEQGRL----QLQADRHQEHIRARDSLIQSLAT 237
L+ E +KL+ Q+ E + R+ ++ D + + +++Q+ +T
Sbjct: 1133 LIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSST 1192
Query: 238 QLELDGFERGPFSER-----QIKNFHKLVRERQEGEAKTANQLMNDFAE-KETLKQKQID 291
E G F E ++K K + E ++ T + ++ A+ +E L Q Q
Sbjct: 1193 GNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQ 1252
Query: 292 EIRDKKTGLGRIIELKSEILSKKQNE--LKNVKYELQQLEGSSDRILELDQELIKAEREL 349
+ D ++ I S +QNE LKN EL Q++ S ++ ++L+ + ++
Sbjct: 1253 VLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNT-KDLLLGKLDI 1311
Query: 350 SKAEKNSNVETLKMEVISLQNEKAD-LDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKAD 408
+ +S L+ K++ L + L QE+E+L K +
Sbjct: 1312 ISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELR-------------KSLQE 1358
Query: 409 KDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKE------- 461
KD IR ++ + S+ +++ + S+ K++ + +D L KL KE
Sbjct: 1359 KDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKA 1418
Query: 462 -----LASSEQNKNHIN-NELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSK 515
L+S+E N +N NEL R + +++ ++++ + E D+ +LK E EK +
Sbjct: 1419 KSDQLLSSNENFTNKVNENELLR--QAVTNLKERILIL------EMDIGKLKGENEKIVE 1470
Query: 516 ----QRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPD 571
+ +F L ++ C + ++ E L+E +L +
Sbjct: 1471 TYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLN 1530
Query: 572 KLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKND-IE 630
+KS + + ++ RD+++ + +Q + E+ LR+K N++++RL+N +E
Sbjct: 1531 AVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLE 1590
Query: 631 EQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVN 690
+++ + E+ VT++E + + + QA+ +Q L + V+
Sbjct: 1591 SEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQAS-VQVESLQEQLNVVS 1649
Query: 691 QEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQL-- 748
+++ E +L +++ + + Q ++H + + EK S L++++QL
Sbjct: 1650 KQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQ------QEEKAMYSAELEKQKQLIA 1703
Query: 749 --EEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLN 806
++ L +V SL + +A + E+ KEE I + N++ Q+ L+
Sbjct: 1704 EWKKNAENLEGKVISLQECLDEANAALDSASRLTEQL-DVKEEQIEELKRQNELRQEMLD 1762
Query: 807 DIKEKVKNI 815
D+++K+ ++
Sbjct: 1763 DVQKKLMSL 1771
Score = 105 bits (261), Expect = 3e-22
Identities = 193/1017 (18%), Positives = 408/1017 (40%), Gaps = 125/1017 (12%)
Query: 34 KQKFDEIFSATRYIKALETLRQVRQTQGQKVKE----YQMELKYLKQYKEKACEIRDQIT 89
K+ D + S+ K L L ++ +K+KE Q EL Q K +R I
Sbjct: 790 KETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIE 849
Query: 90 SKEAQLTSSKEIVKSYENELDPLKNRLKEIE-----HNLSKIMKLDNEIKALDSRKKQME 144
K+ L S KE + EL+ L+ L + +L +E+ L++ K+ +E
Sbjct: 850 EKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLE 909
Query: 145 KDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEK 204
++ ++ +E Q + L L +E+++++ + + E++N L EK
Sbjct: 910 EEIKHHQKIIEDQNQSKMQLLQSL--------QEQKKEMDEFRYQHEQMNATHTQLFLEK 961
Query: 205 SELL------VEQGRLQLQADRHQEHIRARDSLIQSLATQLELD-GFERGPFSERQIKNF 257
E + +EQ + QL +R D ++ L ++ G E+ S+ + +
Sbjct: 962 DEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERL 1021
Query: 258 HKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNE 317
K ++ER E E K N EK KQID++ K +G++ ++I+ +K E
Sbjct: 1022 VKGIKER-ELEIKLLN-------EKNISLTKQIDQL--SKDEVGKL----TQIIQQKDLE 1067
Query: 318 LKNVKYELQQLEGSSDRILELDQEL--IKAEREL------SKAEKNSNVET--------- 360
++ + + + D ++ L Q+L ERE K +NS+++T
Sbjct: 1068 IQALHARISSTSHTQD-VVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIV 1126
Query: 361 --LKMEVISLQNEKA-------------------DLDRTLRKLDQEMEQLNHHTTT---- 395
+ +I LQ+E +L R +R+ D E++ L+ T
Sbjct: 1127 AAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAV 1186
Query: 396 --------------RTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWL 441
Q E L +++ +Q++K++ +T++ QL++ L
Sbjct: 1187 LQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEEL 1246
Query: 442 HSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFE- 500
H ++ D +KL + Q+ +LK ++L+ + + +C ++D
Sbjct: 1247 HQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLL 1306
Query: 501 SDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVIS 560
LD + ++ +S A + L++ ++ + + ++ E I
Sbjct: 1307 GKLDIISPQLSSASLLTPQSAECLRASKSEV--LSESSELLQQELEELRKSLQEKDATIR 1364
Query: 561 DLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIID--LKEKEIPELRNKLQNV 618
LQ D + +T +K+ ++ D + + +Q ++ LKEK++ ++ K +
Sbjct: 1365 TLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLL-IKAKSDQL 1423
Query: 619 NRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQ--QAAK 676
+ N + E E L + +E + I+E +LK KI + + +
Sbjct: 1424 LSSNENFTNKVNENELLRQAVTNLKER-------ILILEMDIGKLKGENEKIVETYRGKE 1476
Query: 677 LQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQE-QIQHLKSTTNELKSEK 735
+ L T + + +EK+ + ++ K +L++++++ + L N +KS +
Sbjct: 1477 TEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQ 1536
Query: 736 LQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKN 795
+ Q R Q+ + E +L E++ +++ LE+ + E +
Sbjct: 1537 EKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYT 1596
Query: 796 TSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKET---ELNKVIAQLSECE 852
A+D+ +++KV + + N +++ Q E+ +LN V Q E
Sbjct: 1597 REALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETA 1656
Query: 853 KHKEKINEDMRLMRQDI-DTQKIQERWLQDNLTLRKRN-EELKEVEEERKQHLKEMGQMQ 910
E ++ + + Q + E + Q+ + E+ K++ E K++ + + + +
Sbjct: 1657 LQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENL-EGK 1715
Query: 911 VLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKK---ELREPQFRDAEEK 964
V+ ++ + +D+ R L Q +EE I K ELR+ D ++K
Sbjct: 1716 VISLQECLDEANAALDSASR-----LTEQLDVKEEQIEELKRQNELRQEMLDDVQKK 1767
Score = 96.7 bits (239), Expect = 1e-19
Identities = 217/1080 (20%), Positives = 452/1080 (41%), Gaps = 182/1080 (16%)
Query: 51 ETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELD 110
+TL + R+ + + +K+ L L+Q E ++ + + +L + E V+ E
Sbjct: 641 DTLLKEREAEVRNLKQ---NLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECL 697
Query: 111 PLKNRLKEIEHNLSKIMKLDN-EIKA-LDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDL 168
N+L ++ + + +K++ EI+A L KK++ ++ ++ E+ +E++ + + L
Sbjct: 698 AGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSAL 757
Query: 169 YHNHQRTVR---EKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQ--- 222
H+ ++ +K+ ++ + + +E+++ + + S L EQ +L ++ +
Sbjct: 758 QLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFI 817
Query: 223 EHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEK 282
E ++ R S +Q ELD + + + +I ++R G K N + + E+
Sbjct: 818 EKLKERSSKLQE-----ELDKYSQA-LRKNEILRQTIEEKDRSLGSMKEENNHLQEELER 871
Query: 283 ETLKQKQIDEIRDKKTGLGRIIELKSEILSK---KQNELKNVKYELQQLEGSSDRILELD 339
+Q + + D KT L + EL SE+ K++ + +K+ + +E + ++L
Sbjct: 872 LREEQSRTAPVADPKT-LDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLL 930
Query: 340 QELIKAERELSK----------------AEKNSNVETLKMEV----ISLQNEKADLDRTL 379
Q L + ++E+ + EK+ +++L+ + L E+ D+
Sbjct: 931 QSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDN 990
Query: 380 RKLDQE--MEQLN------HHTTTRTQMEMLTKDKADKDEQIRKIKSRH----------- 420
+ QE ++ LN H ++ + E L K +++ +I+ + ++
Sbjct: 991 SDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLS 1050
Query: 421 SDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHIN---NELK 477
DE+ L K LH++ + T+D + L ++L + + + NE
Sbjct: 1051 KDEVGKLTQIIQQKDLEIQALHARISSTSHTQD-VVYLQQQLQAYAMEREKVFAVLNEKT 1109
Query: 478 RKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQ-----RAMLAGATAVYSQFIT 532
R+ L + K+ D+ ++ E+ L +L++E +K S + + M S+ I
Sbjct: 1110 RENSHLKTEYHKMMDIVAAK--EAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIR 1167
Query: 533 QLTDENQSCCPVCQR---VFQTEAELQE---VISDLQSKLRLAPDKLKSTESELKKKEKR 586
+ E + CQ V QT + E V S+ +L DKLK ++KK E+
Sbjct: 1168 EKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQ---QVKKMEEW 1224
Query: 587 RDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESA 646
+ +++ V Q ++E+ +L+ ++ V+ D N+ + Q G I E++
Sbjct: 1225 KQQVMTTVQNMQHESAQLQEELHQLQAQVL-VDSD-----NNSKLQVDYTGLIQSYEQNE 1278
Query: 647 KVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSK 706
T ++ F EL V+ I Q K KLD +S +
Sbjct: 1279 -------TKLKNFGQELAQVQHSIGQLC----------------NTKDLLLGKLDIISPQ 1315
Query: 707 IELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREI 766
+ L E ++ KS SE LQ + R+ L+E+ + T ++ +R +
Sbjct: 1316 LSSASLLTPQSAECLRASKSEVLSESSELLQQELE-ELRKSLQEKDATIRTLQENNHR-L 1373
Query: 767 KDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYI 826
D+ S LE ++E E+ ++ +KEK +D+ +
Sbjct: 1374 SDSIAATSELE------RKEHEQ-----------TDSEIKQLKEK--------QDVLQKL 1408
Query: 827 QDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLR 886
KD K K +L LS E K+NE+ L+RQ + ++ER L + +
Sbjct: 1409 LKEKDLLIKAKSDQL------LSSNENFTNKVNEN-ELLRQAV--TNLKERILILEMDIG 1459
Query: 887 K-RNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYE-- 943
K + E K VE R + ++E+Q L+E N+K + L R+K +E
Sbjct: 1460 KLKGENEKIVETYRGK-------------ETEYQALQET--NMKFSMML---REKEFECH 1501
Query: 944 ---EEIIHFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMK 1000
E+ + F++ L+E + + K E+ ++ + + + ++ + DQ ++ +
Sbjct: 1502 SMKEKALAFEQLLKEKE----QGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQ 1557
Query: 1001 MEEI---NKIIRDLWRSTYRGQDIEYIEIR------SDADENVSASDKRRNYNYRVVMLK 1051
ME N++ R + Q++E + S E ++A D+ +V +L+
Sbjct: 1558 MENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLE 1617
Score = 79.7 bits (195), Expect = 1e-14
Identities = 124/598 (20%), Positives = 259/598 (43%), Gaps = 96/598 (16%)
Query: 461 ELASSEQNKNHINNELKRKEEQLSSY-------------EDKLFDVCGSQDFESDLDRLK 507
++ SS+Q N ++NE+ R E ++ + ++C Q+ +L + +
Sbjct: 166 DIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNR 225
Query: 508 -EEIEKSSKQRAMLAGA-----TAVYSQFITQLTD--------EN---QSCCPVCQRVFQ 550
+EI+ + ++L A T + + +L+D EN Q V +
Sbjct: 226 SQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLS 285
Query: 551 TEAELQEVISDLQ-------SKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDL 603
E+Q+ I LQ K+ DK+K +L E RD ++ Q +++
Sbjct: 286 KIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRD----ILRREQEQLNV 341
Query: 604 KEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMEL 663
++++I E + +N+ + +L+ +Q M E+E V + R Q L
Sbjct: 342 EKRQIME---ECENLKLECSKLQPSAVKQ----SDTMTEKERILAQSASVEEVFRLQQAL 394
Query: 664 KDVERKIAQQAAKLQGIDL--DRTVQQVNQEKQEKQHK-LDTVSSKIELNRKLIQDQQEQ 720
D E +I + ++ Q L D ++ E EK+ L +++++ + ++ E
Sbjct: 395 SDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEV 454
Query: 721 IQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVE----LSTEVQSLYREIKDAKEQVSPL 776
I+ + L SE + NL+ ++Q Q++ L E++ L R+ ++A + + +
Sbjct: 455 IKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILI 514
Query: 777 ETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQ 836
+ L K Q E + +I +K+ QD LND K++V + ++D K D K+
Sbjct: 515 KDQLSKQQNEGDSII------SKLKQD-LNDEKKRV-----------HQLEDDKMDITKE 556
Query: 837 KETELNKVI---AQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELK 893
+ + K+I L++ K+K+ + + + ++ + + N++++K N ELK
Sbjct: 557 LDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQ------ESNVSIQKENLELK 610
Query: 894 EVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKEL 953
E +Q+ +E+ +++ M+S +Q N N K E E+ + K+ L
Sbjct: 611 ---EHIRQNEEELSRIRNELMQSLNQ---------DSNSNFKDTLLKEREAEVRNLKQNL 658
Query: 954 REPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIRDL 1011
E + + K + M +LV D+ ++ L++ + + + +E+ N I+ L
Sbjct: 659 SELEQLNENLKKVAFDVKMENEKLVLACEDVRHQ-LEECLAGNNQLSLEK-NTIVETL 714
Score = 62.8 bits (151), Expect = 2e-09
Identities = 133/649 (20%), Positives = 276/649 (42%), Gaps = 102/649 (15%)
Query: 51 ETLRQVRQTQGQKVKEY----QMELKYLKQYKEKACEIRDQITSKEAQLTSSKE------ 100
E L Q R Q+VK+ Q + ++ + ++ ++++++ +AQ+ +
Sbjct: 1205 EELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQ 1264
Query: 101 -----IVKSYENELDPLKN---RLKEIEHNLSKIM--------KLDNEIKALDSRKKQME 144
+++SYE LKN L +++H++ ++ KLD L S
Sbjct: 1265 VDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTP 1324
Query: 145 KDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKL----VDCHRELEKLNKESRLL 200
+ L +V + E L +++++EK+ + + HR + + S L
Sbjct: 1325 QSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELE 1384
Query: 201 NQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKL 260
+E + E +L+ + D Q+ ++ +D LI++ + QL L E F+ + +N +L
Sbjct: 1385 RKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQL-LSSNEN--FTNKVNEN--EL 1439
Query: 261 VRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELK---SEILSKKQNE 317
+R+ + L D + + +K ++ R K+T + E S +L +K+ E
Sbjct: 1440 LRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFE 1499
Query: 318 LKNVK-----YELQQLEGSSDRILELDQEL--IKAERELS---KAEKNSNVETLK---ME 364
++K +E E + EL+Q L +K+ +E + + E++ + LK ME
Sbjct: 1500 CHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQME 1559
Query: 365 VISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQM---EMLTKDKADKDEQIRKIKSRHS 421
+LQNE L + +QE+E+L +H E L + D++ ++RK +
Sbjct: 1560 NTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAE--DREAKLRKKVTVLE 1617
Query: 422 DELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEE 481
++L S + +E+ H S ++ +++L ++K+ ++ +L +E
Sbjct: 1618 EKLVS------SSNAMENASHQASVQVESLQEQLNVVSKQ-------RDETALQLSVSQE 1664
Query: 482 QLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSC 541
Q+ Y L ++L + E ++ K AM + Q I + ++
Sbjct: 1665 QVKQYALSL----------ANLQMVLEHFQQEEK--AMYSAELEKQKQLIAEWKKNAEN- 1711
Query: 542 CPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSII 601
+ +V + L E + L S RL +L KE++ +E+ +RQ ++
Sbjct: 1712 --LEGKVISLQECLDEANAALDSASRLT--------EQLDVKEEQIEELKRQNELRQEML 1761
Query: 602 DLKEKEIPELRNKLQ-NVNRDIQR---------LKNDIEEQETLLGTIM 640
D +K++ L N + V++ + R KN E L+G+I+
Sbjct: 1762 DDVQKKLMSLANSSEGKVDKVLMRNLFIGHFHTPKNQRHEVLRLMGSIL 1810
Score = 48.9 bits (115), Expect = 3e-05
Identities = 100/519 (19%), Positives = 208/519 (40%), Gaps = 115/519 (22%)
Query: 590 MLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVC 649
M G + + D + KEI + L++ N +++L D+EE + E++++
Sbjct: 39 MEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEE----------KHEASEIQ 88
Query: 650 LTDVTIMERFQMELKDVE------RKIA--QQAAKLQ--------GIDLDRTVQQVNQEK 693
+ + R Q++ K+VE R+IA Q KLQ G + T +
Sbjct: 89 IKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAY 148
Query: 694 QEKQHKL----------DTVSSKIELNR--KLIQDQQEQIQH---------LKSTTNELK 732
H D +SS+ E+NR + + ++ H + T N +
Sbjct: 149 GISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQ 208
Query: 733 SEKLQISTNLQ-----RRQQLEEQTVELS----------TEVQSLYR-EIKDAKEQVSPL 776
SE ++ ++ R Q++++ E+S TE+ +R E+ D +E++ L
Sbjct: 209 SEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEEL 268
Query: 777 ETTLEK-----FQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKD 831
E L++ + + ++ + T + +K+ K K++ + +KDI + ++
Sbjct: 269 ENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTK-KMEQLEDKIKDINKKLSSAEN 327
Query: 832 --DYKKQKETELNKVIAQ-LSECE--------------KHKEKINEDMRLMRQDIDTQKI 874
D ++++ +LN Q + ECE K + + E R++ Q +++
Sbjct: 328 DRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEV 387
Query: 875 ---------------------QERWL-QDNLTLRKRNEELKEVEEERKQHLKEMGQMQVL 912
Q+ L +DNL L+ R E L++ + Q +E+ QM +L
Sbjct: 388 FRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEEL-QMSLL 446
Query: 913 QMKSEHQKLE----ENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKYREM 968
++ +E++ ++ +I H+L L + +E+ ++ +E + EE R+
Sbjct: 447 KLNNEYEVIKSTATRDISLDSELHDLRLNLEA--KEQELNQSISEKETLIAEIEELDRQN 504
Query: 969 MIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKI 1007
+ L+ L D I K +E ++
Sbjct: 505 QEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRV 543
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 137 bits (344), Expect = 8e-32
Identities = 208/1042 (19%), Positives = 442/1042 (42%), Gaps = 179/1042 (17%)
Query: 51 ETLRQVRQTQGQKVK-EYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENEL 109
E L + Q +K ++Q+E K +K+ E+A E ++I A+LT+ K + E+E
Sbjct: 897 ENLLDAEERCDQLIKAKFQLEAK-IKEVTERA-EDEEEIN---AELTAKK---RKLEDEC 948
Query: 110 DPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLY 169
LK + ++E L+K+ K E A +++ K + ++ S G DE + L
Sbjct: 949 SELKKDIDDLELTLAKVEK---EKHATENKVKNLTEELS-----------GLDETIAKLT 994
Query: 170 HNHQRTVREKERKLVDCHRELEK---LNKESRLLNQEKSEL---LVEQGRLQLQADRHQE 223
+ ++ L D E +K LNK L Q+ +L L ++ +L++ +R++
Sbjct: 995 REKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKR 1054
Query: 224 HIRARDSLIQSLATQLELD------GFERGPFSERQIKN-----------FHKLVRERQE 266
+ L Q LE D ++ F Q+++ F K ++E Q
Sbjct: 1055 KLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQA 1114
Query: 267 GEAKTANQLMNDFAEK-ETLKQ-----KQIDEIRDKKTGLGRIIELKSEILSKKQNELKN 320
+ ++ + A + +T KQ ++++E+ ++ G + + E+ K++ E
Sbjct: 1115 RIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLK 1174
Query: 321 VKYELQQL------------EGSSDRILELDQEL-----IKAERELSKAEKNSNVETLKM 363
++ +L++ + +D + EL +++ +K + E K+E ++ L
Sbjct: 1175 LRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSS 1234
Query: 364 EVISLQNEKADLDRTLRKL-DQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSD 422
+ S+ KA+L++ R L DQ E + + + LT K+ + ++ SR +
Sbjct: 1235 SMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGEL-SRQLE 1293
Query: 423 ELTSLLGYFPNKKQL----EDWLHSKSKEINQTRDRLAK-----------LNKELASSEQ 467
E S++ KQ + L + +E N+ ++ LA L ++ ++
Sbjct: 1294 EKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQE 1353
Query: 468 NKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVY 527
K + L + +++ + K +E+D + EE+E++ K+ A
Sbjct: 1354 GKAELQRALSKANSEVAQWRTK---------YETDAIQRTEELEEAKKKLA--------- 1395
Query: 528 SQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRR 587
Q + ++ ++ C + +T+ LQ + DL + ++ S + L KK++
Sbjct: 1396 -QRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDV----ERANSLAAALDKKQRNF 1450
Query: 588 DEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAK 647
D++L ++ + + E+ + ++++ ++ +LKN EE L T+ E ++ +
Sbjct: 1451 DKVLA---EWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLE 1507
Query: 648 VCLTDVT--IMER--------------------FQMELKDVERKIAQQAAKLQGIDLDRT 685
+ D+T I E Q+ L++ E + + AK+ I L+ T
Sbjct: 1508 QEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELT 1567
Query: 686 V-------------QQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELK 732
+++ Q K+ Q ++T+ S ++ ++ + E I+ K +L
Sbjct: 1568 QVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAE---VRSRNEAIRLKKKMEGDLN 1624
Query: 733 SEKLQIS-------TNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQ 785
++Q+S L+ + ++ Q + + R +D KEQ++ +E Q
Sbjct: 1625 EIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQA 1684
Query: 786 EKEEL---INKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELN 842
E EEL + + + K+A+ +L D E+V+ +H + + KK+ ET+L
Sbjct: 1685 EVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIH--------TKKKLETDLM 1736
Query: 843 KVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQD-NLTLRKRNEELKEVEEERKQ 901
++ +++ + + E + D + + QD + L + + L++ ++ +
Sbjct: 1737 QLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQH 1796
Query: 902 HLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRDA 961
L E Q+ + K + QKLE I ++ G QK E + K LR+ + R
Sbjct: 1797 RLDEAEQLALKGGKKQIQKLETRIRELEFELE---GEQKKNTESV----KGLRKYERRVK 1849
Query: 962 EEKYR---EMMIVMRTTELVNK 980
E Y+ + V+R +LV+K
Sbjct: 1850 ELTYQSEEDRKNVLRLQDLVDK 1871
Score = 81.6 bits (200), Expect = 4e-15
Identities = 123/601 (20%), Positives = 261/601 (43%), Gaps = 113/601 (18%)
Query: 436 QLEDWLHSKSKEINQTRDRLAK-------LNKELASSEQNKNHINNELKRKEEQLSSYED 488
+ E + + +E +T+D LAK L ++L + Q KN + +++ + E L E+
Sbjct: 845 ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEE 904
Query: 489 KLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRV 548
+ D F+ + ++KE E++ + + A TA +L DE C +
Sbjct: 905 RC-DQLIKAKFQLEA-KIKEVTERAEDEEEINAELTAKK----RKLEDE-------CSEL 951
Query: 549 FQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEI 608
+ +L+ ++ ++ + +K+K+ EL + + + L ++++ + ++ +
Sbjct: 952 KKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLD---ETIAKLTREKKALQEAHQQAL 1008
Query: 609 PELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVER 668
+L+ + VN + + K+ +E+Q L + + +E+ +V L ER + +L+ +
Sbjct: 1009 DDLQAEEDKVN-SLNKTKSKLEQQVEDLESSLEQEKKLRVDL------ERNKRKLEG-DL 1060
Query: 669 KIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTT 728
K+AQ++ +DL+ QQ+++ ++K + + SK+E + L Q++I+ L++
Sbjct: 1061 KLAQESI----LDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARI 1116
Query: 729 NELKSE------------------------------------KLQISTNLQR-------R 745
EL+ E QI N +R R
Sbjct: 1117 EELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLR 1176
Query: 746 QQLEEQTVELSTEVQSLYRE----IKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIA 801
+ LEE T++ V +L ++ + + EQ+ L+ +K ++EK E K+
Sbjct: 1177 RDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEF--------KLE 1228
Query: 802 QDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKI-NE 860
D L+ E V ++ I ++D + + + E ++ LSE K ++ E
Sbjct: 1229 IDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNE----EIQRSLSELTTQKSRLQTE 1284
Query: 861 DMRLMRQDIDTQKIQERWLQDNLTLRKRNEELK-EVEEERK-----QHLKEMGQMQVLQM 914
L RQ + + I + + ++ EELK ++EEE K H + + +
Sbjct: 1285 AGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLL 1344
Query: 915 KSEHQKLEENIDNIKR-----NHNLALGRQKGYEEEIIHFKKELRE------PQFRDAEE 963
+ ++++ +E ++R N +A R K YE + I +EL E + +D+EE
Sbjct: 1345 REQYEEEQEGKAELQRALSKANSEVAQWRTK-YETDAIQRTEELEEAKKKLAQRLQDSEE 1403
Query: 964 K 964
+
Sbjct: 1404 Q 1404
Score = 47.8 bits (112), Expect = 6e-05
Identities = 72/323 (22%), Positives = 139/323 (43%), Gaps = 57/323 (17%)
Query: 48 KALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYEN 107
+A ETL+ +R QGQ +K+ Q+ L + +E ++++Q+ E + + V+
Sbjct: 1636 QAAETLKHLRSVQGQ-LKDTQLHLDDALRGQE---DLKEQLAIVERRANLLQAEVEELRA 1691
Query: 108 ELDPLKNRLKEIEHNL----SKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDE 163
L+ + K E L ++ L + +L KK++E D +L+ ++E +
Sbjct: 1692 TLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDA-- 1749
Query: 164 QLNDLYHNHQRTVREKERK-LVDCHRELEKLNKE---SRLLNQEKSELLVEQGRLQLQAD 219
R EK +K + D E+L KE S L + K L LQ + D
Sbjct: 1750 ----------RNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLD 1799
Query: 220 RHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQ---EGEAKTANQLM 276
A QL L G ++QI+ +RE + EGE K + +
Sbjct: 1800 E---------------AEQLALKG------GKKQIQKLETRIRELEFELEGEQKKNTESV 1838
Query: 277 NDFAEKE-TLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRI 335
+ E +K+ D+K ++ L+ +++ K Q ++K+ K + ++ + ++
Sbjct: 1839 KGLRKYERRVKELTYQSEEDRK----NVLRLQ-DLVDKLQVKVKSYKRQAEEADEQANAH 1893
Query: 336 LELDQELIKAERELSKAEKNSNV 358
L + KA+ EL +AE+ +++
Sbjct: 1894 L---TKFRKAQHELEEAEERADI 1913
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 136 bits (343), Expect = 1e-31
Identities = 198/1010 (19%), Positives = 436/1010 (43%), Gaps = 157/1010 (15%)
Query: 62 QKVKEYQMELKYLKQYKEKACE-IRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIE 120
++ +E EL K+ E C ++ I E LT ++ + EN++ L + +E
Sbjct: 931 EEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALE 990
Query: 121 HNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKME---KVFQGTDEQLNDLYHNHQRTVR 177
N+SK+ K E K+L +Q D E+K+ K+ ++Q +DL +
Sbjct: 991 ENISKLTK---EKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGS-----L 1042
Query: 178 EKERKL-VDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLA 236
E+E+KL D R KL E L ++S + +E + Q++ E ++ ++ + L
Sbjct: 1043 EQEKKLRADLERAKRKL--EGDLKMSQESIMDLENDKQQIE-----EKLKKKEFELSQLQ 1095
Query: 237 TQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDK 296
+++ + F +++IK + E +E E + + L ++ + ++++EI ++
Sbjct: 1096 AKIDDEQVHSLQF-QKKIKELQARIEELEE-EIEAEHTLRAKIEKQRSDLARELEEISER 1153
Query: 297 KTGLGRIIELKSEILSKKQNELKNVKYELQQL------------EGSSDRILELDQEL-- 342
+ E+ K++ E + ++ +L++ + +D + EL +++
Sbjct: 1154 LEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDN 1213
Query: 343 ---IKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQM 399
+K + E K+E ++ + + +L K++++RT R ++ + ++ +TQ+
Sbjct: 1214 LQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQL 1273
Query: 400 -EMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKL 458
L KA Q ++ R +E SL+ KQ L + +E+ + + K
Sbjct: 1274 IHDLNMQKARLQTQNGELSHR-VEEKESLISQLTKSKQA---LTQQLEELKRQMEEETKA 1329
Query: 459 NKELASSEQNKNH---INNELKRKEEQLSSYEDKLFDVCGSQ------DFESDLDRLKEE 509
+A + Q+ H + E +E++ + + S+ +E+D + EE
Sbjct: 1330 KNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEE 1389
Query: 510 IEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLA 569
+E++ K+ A Q + + + ++ C + +T+ LQ + DL L +
Sbjct: 1390 LEEAKKKLA----------QRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERS 1439
Query: 570 ---------------------PDKLKSTESELKKKEKR-RDEMLGLVPMR---QSIIDLK 604
KL +++EL+ +K R L MR + ++D
Sbjct: 1440 HTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQL 1499
Query: 605 E---KEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVT-IMERFQ 660
E +E L+ ++ ++ I +++E E + E+ +V L +V +E +
Sbjct: 1500 ETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEE 1559
Query: 661 MELKDVERKIAQQAAKLQG--IDLDRTVQQVNQEKQEKQHKLDTV--------SSKIELN 710
++ V+ +++Q ++L I+ D ++Q+ + Q L +V + + L
Sbjct: 1560 SKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLK 1619
Query: 711 RKLIQDQQE-QIQ-------------HLKSTTNELKSEKLQISTNLQRRQQLEEQTVELS 756
+K+ D E +IQ HL++ +LK +L + L+ + L+EQ +
Sbjct: 1620 KKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVE 1679
Query: 757 TEVQSLYREIKDAKEQVSPLETTLEKFQQE------KEELINKKNTSNKIAQDKLNDIKE 810
L E+++ K + E T +QE + +L++ +NTS +N K+
Sbjct: 1680 RRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTS------LINTKKK 1733
Query: 811 KVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDID 870
+I ++EN IQ+ ++ +K K+ + A ++E K ++ + + M+++++
Sbjct: 1734 LEADIAQCQAEVENSIQESRNAEEKAKKAITD--AAMMAEELKKEQDTSAHLERMKKNLE 1791
Query: 871 TQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKR 930
Q +++ LQ L +E +Q + G+ Q+ ++++ ++LE +D ++
Sbjct: 1792 -QTVKD--LQHRL-------------DEAEQLALKGGKKQIQKLENRVRELENELDVEQK 1835
Query: 931 NHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKYREMMIVMRTTELVNK 980
AL YE ++ KE+ AEE ++ ++R +LV+K
Sbjct: 1836 RGAEALKGAHKYERKV----KEMT----YQAEEDHKN---ILRLQDLVDK 1874
Score = 122 bits (307), Expect = 2e-27
Identities = 189/890 (21%), Positives = 367/890 (41%), Gaps = 102/890 (11%)
Query: 38 DEIFSATRYIKALETLR-QVRQTQGQKVKEYQMELKYLKQYKEKACE---IRDQITSKEA 93
DE + ++ K ++ L+ ++ + + + E+ + K KQ + A E I +++
Sbjct: 1100 DEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASG 1159
Query: 94 QLTSSKEIVKSYENELDPLKNRLKE--IEHNLS----------KIMKLDNEIKALDSRKK 141
++ E+ K E E ++ L+E ++H + + +L +I L K+
Sbjct: 1160 ATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQ 1219
Query: 142 QMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLN 201
++EK+ SEL+ +++ + E L+ N +RT R E + + + E+ + LN
Sbjct: 1220 KLEKEKSELKMEIDDMASNI-EALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLN 1278
Query: 202 QEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLV 261
+K+ L + G L + + + I Q+L QLE +L
Sbjct: 1279 MQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLE------------------ELK 1320
Query: 262 RERQEGEAKTANQLMNDFAEKE---TLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNEL 318
R+ +E E K N + + L ++Q +E ++ K L R LSK +E+
Sbjct: 1321 RQMEE-ETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRA-------LSKANSEV 1372
Query: 319 KN--VKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVIS-----LQNE 371
KYE ++ R EL++ K + L +AE+N+ K + LQ E
Sbjct: 1373 AQWRTKYETDAIQ----RTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGE 1428
Query: 372 KADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYF 431
DL R L + L+ ++ K K D+ + + + S L++ L
Sbjct: 1429 VEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKM 1488
Query: 432 PNK-KQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKL 490
N +++ D L + +E ++ ++ L +++A + +N K E++ S + L
Sbjct: 1489 RNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVAL 1548
Query: 491 FDVCGSQDFE-SDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVF 549
+V GS + E S + R++ E+ S+ ++ L + I QL +Q Q V
Sbjct: 1549 EEVEGSLEHEESKILRVQLEL---SQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVL 1605
Query: 550 QTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIP 609
E I LRL K E +L + E + + Q + + ++
Sbjct: 1606 DAE------IRSRNDALRLK----KKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLK 1655
Query: 610 ELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERF-QMELKDVER 668
+ + L + R + LK + E G ++ E E KV L R + EL D
Sbjct: 1656 DSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASD 1715
Query: 669 KIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTT 728
++ Q Q L T +++ + + Q + V + I+ +R + ++ I
Sbjct: 1716 RV--QLLHSQNTSLINTKKKLEADIAQCQAE---VENSIQESRNAEEKAKKAITDAAMMA 1770
Query: 729 NELKSEKLQISTNLQRRQQLEEQTVE----LSTEVQSLY-----REIKDAKEQVSPLETT 779
ELK E+ S +L+R ++ EQTV+ E + L ++I+ + +V LE
Sbjct: 1771 EELKKEQ-DTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENE 1829
Query: 780 LEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKET 839
L+ Q+ E + + + ++ +E KNI ++D+ + +Q YK+Q E
Sbjct: 1830 LDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILR-LQDLVDKLQAKVKSYKRQAEE 1888
Query: 840 ELNKVIAQLSECEKHKEKINE-------------DMRLMRQDIDTQKIQE 876
+ QLS C + + ++ E +R +D+ +QK++E
Sbjct: 1889 AEEQANTQLSRCRRVQHELEEAAERADIAESQVNKLRAKSRDVGSQKMEE 1938
Score = 84.3 bits (207), Expect = 6e-16
Identities = 156/802 (19%), Positives = 326/802 (40%), Gaps = 150/802 (18%)
Query: 349 LSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQL-NHHTTTRTQMEMLTKDKA 407
L AE + T+K + + E A + ++L+++M L + Q++ T++
Sbjct: 844 LKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLM 903
Query: 408 DKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQ 467
D +E+ G +K LE +K KE+ + + ++N EL + ++
Sbjct: 904 DAEERCE--------------GLIKSKILLE----AKVKELTERLEEEEEMNSELVAKKR 945
Query: 468 NKNHINNELKRK-----------EEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQ 516
N + LKR E++ + E+K+ ++ ++ L+E I K +K+
Sbjct: 946 NLEDKCSSLKRDIDDLELTLTKVEKEKHATENKV------KNLSEEMTALEENISKLTKE 999
Query: 517 RAMLAGA-----------------TAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVI 559
+ L A + + Q TD+ + ++ + A+L+
Sbjct: 1000 KKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGS---LEQEKKLRADLERAK 1056
Query: 560 SDLQSKLRLAPDKL-------KSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELR 612
L+ L+++ + + + E +LKKKE ++ + Q +K+I EL+
Sbjct: 1057 RKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQ 1116
Query: 613 NKLQNVNRDIQ---RLKNDIEEQETLLGTIMPE-----EESAKVCLTDVTIMER----FQ 660
+++ + +I+ L+ IE+Q + L + E EE++ + + ++ FQ
Sbjct: 1117 ARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQ 1176
Query: 661 MELKDVE--------------RKIAQQAAKL--QGIDLDRTVQQVNQEKQEKQHKLDTVS 704
+D+E +K A A+L Q +L R Q++ +EK E + ++D ++
Sbjct: 1177 KMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMA 1236
Query: 705 SKIELNRKLIQDQQEQIQHLKSTTNELKS---EKLQISTNL-QRRQQLEEQTVELSTEVQ 760
S IE K + + + ++ +E+K+ ++ Q+ +L ++ +L+ Q ELS V+
Sbjct: 1237 SNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVE 1296
Query: 761 SLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLND---IKEKVKNIHG 817
I + L LE+ +++ EE KN Q +D ++E+ +
Sbjct: 1297 EKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQE 1356
Query: 818 YMKDIENYIQDGKDD---YKKQKET----------ELNKVIAQ-LSECEKHKEKINE--- 860
+++ + + ++ + ET E K +AQ L E E++ E N
Sbjct: 1357 AKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCA 1416
Query: 861 -----DMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMG-------- 907
RL + D + ER TL K+ +V E KQ L E
Sbjct: 1417 SLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQK 1476
Query: 908 -----QMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQ--FRD 960
++ +M++ ++++ + ++ ++R + E+I K L+E + +
Sbjct: 1477 ESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKL 1536
Query: 961 AEEKYREMMIVMRTTE-----------LVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIR 1009
E++ ++ + + E V +L LD+ +++ K EEI ++ R
Sbjct: 1537 VEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIE----KDEEIEQLKR 1592
Query: 1010 DLWRSTYRGQDIEYIEIRSDAD 1031
+ R+ Q + EIRS D
Sbjct: 1593 NSQRAAEALQSVLDAEIRSRND 1614
Score = 68.2 bits (165), Expect = 4e-11
Identities = 101/508 (19%), Positives = 211/508 (41%), Gaps = 57/508 (11%)
Query: 34 KQKFDE----IFSATRYIKALET-LRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQI 88
KQK DE + +A + ++L T L ++R + V + + + K +E+ ++ +QI
Sbjct: 1461 KQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQI 1520
Query: 89 TSKEAQLTSSKEIVKSYENELDPLKNRLKEI----EHNLSKIMKLDNEIKALDSRKKQME 144
L +++ K E E L+ L+E+ EH SKI+++ E+ +
Sbjct: 1521 AETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQV-------- 1572
Query: 145 KDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRL---LN 201
SEL+ K+ + DE++ L N QR E + ++D E+ N RL +
Sbjct: 1573 --KSELDRKVIE----KDEEIEQLKRNSQRAA-EALQSVLDA--EIRSRNDALRLKKKME 1623
Query: 202 QEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLV 261
+ +E+ ++ G Q Q+H+R ++ +QL LD R S +K +V
Sbjct: 1624 GDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKD--SQLHLDDALR---SNEDLKEQLAIV 1678
Query: 262 RERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNV 321
R + ++ + E ++ E+ D + + + +++ K K +
Sbjct: 1679 ERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTK----KKL 1734
Query: 322 KYELQQLEGSSDRILELDQELIKAERELSKAEKNSNV--ETLKMEVISLQNEKADLDRTL 379
+ ++ Q + + + QE AE + KA ++ + E LK E Q+ A L+R
Sbjct: 1735 EADIAQCQAEVENSI---QESRNAEEKAKKAITDAAMMAEELKKE----QDTSAHLERMK 1787
Query: 380 RKLDQEMEQLNHHTTT---------RTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGY 430
+ L+Q ++ L H + Q++ L + + ++ + R ++ L Y
Sbjct: 1788 KNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKY 1847
Query: 431 FPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKL 490
K++ K I + +D + KL ++ S ++ + + + + +L
Sbjct: 1848 ERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHEL 1907
Query: 491 FDVCGSQDF-ESDLDRLKEEIEKSSKQR 517
+ D ES +++L+ + Q+
Sbjct: 1908 EEAAERADIAESQVNKLRAKSRDVGSQK 1935
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 135 bits (341), Expect = 2e-31
Identities = 233/1120 (20%), Positives = 482/1120 (43%), Gaps = 185/1120 (16%)
Query: 20 QEDSNWPLSEGKALKQKFDEIFSATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQ--- 76
Q++ N + E +AL+++ + +E LR+ Q + +++ E L
Sbjct: 726 QKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVV 785
Query: 77 YKEKACE-IRDQITSKEAQLTSSKEIVKSYENELDPLKNR-----------LKEIEHNLS 124
+KE + + ++I + L +++ KS + E K L+E E
Sbjct: 786 HKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQ 845
Query: 125 KIMKLDNEIKALDSR----KKQMEKDNSELEEKMEKVFQGTDE--QLNDLYHNHQRTVRE 178
+I+ L E + DS K ++ EL+EK +V + +E QL + N T++
Sbjct: 846 EIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQT 905
Query: 179 KERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQ 238
ER+ +L++ +E + L QEK +L Q LQ++ D+ + I D++ ++ TQ
Sbjct: 906 VEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIH--DTVNMNIDTQ 963
Query: 239 LELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKT 298
Q++N + +++ QE T N TLK K +E+
Sbjct: 964 -------------EQLRNALESLKQHQE----TIN----------TLKSKISEEV----- 991
Query: 299 GLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNV 358
S L ++N K E QQ D+ +L+ K + L+ K++ +
Sbjct: 992 ---------SRNLHMEENT-GETKDEFQQKMVGIDKKQDLEA---KNTQTLTADVKDNEI 1038
Query: 359 ETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKS 418
+ ++ SL EK +L + L + E EQL T + +EM +++ E++R +
Sbjct: 1039 IEQQRKIFSLIQEKNELQQMLESVIAEKEQLK--TDLKENIEMTIENQ----EELRLL-- 1090
Query: 419 RHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKR 478
DEL +K + K E+++T DRLA++ ++L Q +L
Sbjct: 1091 --GDELKKQQEIVAQEK---NHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLN 1145
Query: 479 KEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDEN 538
+E++S + K+ ++ ++ +++L + +E +R LA + + +T E
Sbjct: 1146 VQEEMSEMQKKINEI---ENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKER 1202
Query: 539 QSCCPVCQRVFQTEAE-LQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMR 597
+ + Q+ F+TE + L+ I ++++ ++LK LK+ ++ DE+ V +
Sbjct: 1203 KVLKEL-QKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEK 1261
Query: 598 QSIIDLKEKEIPELRNKLQN---VNRDIQRLKNDIEE----QETLLGTIMPEEESAKVCL 650
+ I + +++ + KLQ V + Q L +++E QET+ + E+S
Sbjct: 1262 TAQI-INTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTT--- 1317
Query: 651 TDVTIMERFQMELKDVERKIAQQAAKLQGIDLDR----TVQQVNQEKQE--KQHKLDTVS 704
D T + R +ME + K + +++ + +R T+++ + K + K+H +T++
Sbjct: 1318 KDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLA 1377
Query: 705 SKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYR 764
E K Q+Q ++ + T ++ SE Q ++E + + LS +Q +
Sbjct: 1378 KIQESQSK--QEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHD 1435
Query: 765 EIKDAKEQVSPLETTLEKFQ-------------------------------QEKEELINK 793
E+K ++ L+ E Q +E+EE IN+
Sbjct: 1436 EMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINE 1495
Query: 794 KNTS------------------NKIAQDKLNDIKEKVKNIH-GYMKDIENYIQDGKD--D 832
+ N Q+K+ +I EK + + + +++ + + K +
Sbjct: 1496 LRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKE 1555
Query: 833 YKKQKETELNKVIAQLSECEKHKEKINEDMRLM-RQDIDTQKIQERWLQDNLTLRKRNEE 891
++K K++ L + +++ E ++ E++++M ++ + +++QE + L++ +E
Sbjct: 1556 HRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKE 1615
Query: 892 ----LKEVEEERKQHLK---------EMGQMQVLQMKSEHQKLE-ENI--DNIK----RN 931
+KE +E+ Q LK +M +++ L+ + E QKL ENI +NI+ +
Sbjct: 1616 IVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILH 1675
Query: 932 HNLALGRQKGYEEEIIHFKKELREPQFRDAEEKYREMMI----VMRTTELVNKDLDIYYK 987
NL R E + + +E + + +E RE + ++V+ L + +
Sbjct: 1676 ENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQE 1735
Query: 988 TLDQAIMKFHSMKMEEINKIIRDLWRS--TYRGQDIEYIE 1025
T+D+ + S K EI+ + +DL S + QD++ E
Sbjct: 1736 TIDK-LRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQE 1774
Score = 123 bits (308), Expect = 1e-27
Identities = 199/980 (20%), Positives = 435/980 (44%), Gaps = 124/980 (12%)
Query: 27 LSEGKALKQKFDEIFSATRYIKA-----LETLRQVRQTQGQKVKEYQMELKYLKQYKEKA 81
L E +++ ++ D++ S +K E LR+ +K +E ++ +LK+++E
Sbjct: 1678 LEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETI 1737
Query: 82 CEIR-------DQITSKEAQLTSSKEIVKSYE----NELDPLKNRLKEIEHNLSKIMKLD 130
++R ++I++ + L S + +K+ + EL LKE + + K+ +
Sbjct: 1738 DKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIV 1797
Query: 131 NE-IKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRE 189
+E L + +K +E N++L+EK++++ + + QL L ++ V E ++K+ + +
Sbjct: 1798 SEKTDKLSNMQKDLENSNAKLQEKIQEL-KANEHQLITL----KKDVNETQKKVSEMEQL 1852
Query: 190 LEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLAT-QLELDGFERGP 248
+++ +S L++ + E L +L + + ++ RD+L + T +LE D
Sbjct: 1853 KKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERD------ 1906
Query: 249 FSERQIKNFHKLVRERQ---EGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIE 305
Q+K + + R + E KTA L + KET +D++R+K
Sbjct: 1907 ----QLKESLQETKARDLEIQQELKTARMLSKE--HKET-----VDKLREK--------- 1946
Query: 306 LKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEV 365
+S+K ++ +++ +L + S D + + QEL K E +L + +++ N+ K+
Sbjct: 1947 -----ISEKTIQISDIQKDLDK---SKDELQKKIQELQKKELQLLRVKEDVNMSHKKI-- 1996
Query: 366 ISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELT 425
NE L + + M+ + R LTK + E+IR I ++ DEL
Sbjct: 1997 ----NEMEQLKKQFEAQNLSMQSV------RMDNFQLTKKLHESLEEIR-IVAKERDELR 2045
Query: 426 SLLGYFPNKKQLEDWLHSKSKEINQTR-DRLAKLNKELASSEQNKNHINNELKRKEEQLS 484
+ K + + ++ + + I + R + K K L S Q H+ L+ E+ S
Sbjct: 2046 RIKESL--KMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQ--HLTESLR---EKCS 2098
Query: 485 SYEDKLFDVCGSQDFESDLDRLKEEIEKS---SKQRAMLAGATA----VYSQFITQLTDE 537
++ L D L+RL ++EK K+ +M A + ++ I +L
Sbjct: 2099 RIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTA 2158
Query: 538 NQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMR 597
NQ C R+ + +L+ V+S + + + E + + +++ E+L +
Sbjct: 2159 NQRCSMEFHRIMK---KLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHL 2215
Query: 598 QSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVT--- 654
Q D+ +E+ +L+ QN++ I+ + D E E +I E + ++T
Sbjct: 2216 QQDCDVPSRELRDLKLN-QNMDLHIEEILKDFSESE--FPSIKTEFQQVLSNRKEMTQFL 2272
Query: 655 ---IMERFQME-LKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELN 710
+ RF +E LK+ +K + ++ +R + +N E E + + T+S + E +
Sbjct: 2273 EEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMN-ESTEFEERSATISKEWEQD 2331
Query: 711 RKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQ--RRQQLEEQTVELSTE-VQSLYREIK 767
K ++++ E++ T + Q++ Q + + + +L+TE ++ L +
Sbjct: 2332 LKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLH 2391
Query: 768 DAKEQVSPLETTLEKFQQEKEELINKKNTSNKIA--QDKLNDIKEKVKNIHGYMKDIENY 825
+AKE E+ + K Q+E E T++ IA Q K+++ + ++ ++ +++
Sbjct: 2392 EAKESAMHKESKIIKMQKELEV------TNDIIAKLQAKVHESNKCLEKTKETIQVLQDK 2445
Query: 826 IQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTL 885
+ G YK++ E K++ E K+ ++ +++ + ++ QK R L++NL
Sbjct: 2446 VALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRR 2505
Query: 886 RKRNEELKEVEEERKQHLKE-----------MGQMQVLQMKSEHQKLEENIDNIKRNHNL 934
++ ++ + E + + L +KSEH +LE+ I +K+ +
Sbjct: 2506 SQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQ 2565
Query: 935 ALGRQKGYEEEIIHFKKELR 954
+ ++ H E++
Sbjct: 2566 LIKQKNELLSNNQHLSNEVK 2585
Score = 122 bits (307), Expect = 2e-27
Identities = 220/1041 (21%), Positives = 450/1041 (43%), Gaps = 175/1041 (16%)
Query: 20 QEDSNWPLSEGKALKQKF--DEIFSATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQY 77
++D L E K L QK ++I + TR + +L ++ + ++ + L + +
Sbjct: 372 EKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKM 431
Query: 78 KEK----ACEIRDQITSKEAQLTSS--KEIVKSYENELDPLKNRL---KEIEHN-LSKIM 127
K I IT+K +L+ + +EI +S +E D N L EIE N +K++
Sbjct: 432 KNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLL 491
Query: 128 KLDNEIKALDSRK----------KQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVR 177
+N L+S + +Q+ + E+E K+++ L++ ++T +
Sbjct: 492 NQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKE-----KNDLDEFEALERKTKK 546
Query: 178 EKERKLVDCHRELEKLNKESRLLNQE-------KSELLVEQG----RLQLQADRHQ---- 222
++E +L+ L+ L K + + NQ+ K ELL E+ +LQ D +
Sbjct: 547 DQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENI 606
Query: 223 --------EHIRARDSLIQSL--ATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTA 272
E I + Q+L A + LD F +++ + ++E+ + A T
Sbjct: 607 KMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAF----LRSENLELKEKMKELATTY 662
Query: 273 NQLMNDF----AEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELK-NVKYELQQ 327
Q+ ND ++ E K+ Q+D ++ ++ I +L S I K +L N+ +
Sbjct: 663 KQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNL-----E 717
Query: 328 LEGS-SDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEM 386
LEG +D EL++E+ + E + S +++L EV L+ E D L + E
Sbjct: 718 LEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEK 777
Query: 387 EQLNH---HTTTRTQ--MEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWL 441
++L H +R Q +E + K K D KS + F N K L
Sbjct: 778 DKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQE--------FQNFKTLHMDF 829
Query: 442 HSKSKEINQTRDRL----AKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQ 497
K K + + +R+ L+KE + + + EL K ++L ++K +V Q
Sbjct: 830 EQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQEL---QEKTREV---Q 883
Query: 498 DFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQ- 556
+ +++++LKE++E + + ++ + Q +E ++ + Q + LQ
Sbjct: 884 ERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQI 943
Query: 557 -------------EVISDLQSKLRLAPDKLKSTESELKK-KEKRRDEMLGLVPM------ 596
+ D Q +LR A + LK + + K K +E+ + M
Sbjct: 944 ERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGE 1003
Query: 597 -----RQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLT 651
+Q ++ + +K+ E +N Q + D++ N+I EQ+ + +++ E+ + L
Sbjct: 1004 TKDEFQQKMVGIDKKQDLEAKNT-QTLTADVK--DNEIIEQQRKIFSLIQEKNELQQMLE 1060
Query: 652 DVTI-MERFQMELKD-VERKIA-QQAAKLQGIDLDRTVQQVNQEKQ-------------- 694
V E+ + +LK+ +E I Q+ +L G +L + + V QEK
Sbjct: 1061 SVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCD 1120
Query: 695 ---EKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQ 751
E + KL S +++ ++ + + QE++ ++ NE+++ K ++ + +E +
Sbjct: 1121 RLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETE 1180
Query: 752 TVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEK 811
+EL+ ++ Y E+K ++ L+ + F+ E++ L + +I L KE+
Sbjct: 1181 RLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHL---RGYIREIEATGL-QTKEE 1236
Query: 812 VKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQD--- 868
+K H ++K+ + I D ++ +E I + EK K+ E++ ++ ++
Sbjct: 1237 LKIAHIHLKEHQETI-----DELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQEL 1291
Query: 869 -------IDTQK--------IQERWLQDNLTLR-------KRNEELKEVEEERKQHLKEM 906
+TQ+ ++ +D+ TL + NE+ +E +EE K KE
Sbjct: 1292 LPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKER 1351
Query: 907 GQMQVLQ--MKSEHQKLEENI 925
++ ++ ++ +H +L+E+I
Sbjct: 1352 DNLKTIKEALEVKHDQLKEHI 1372
Score = 110 bits (276), Expect = 6e-24
Identities = 195/1029 (18%), Positives = 448/1029 (43%), Gaps = 152/1029 (14%)
Query: 48 KALETLRQVRQTQGQKV--KEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSY 105
K LE + Q + Q++ KE Q +K + + +EK E++ ++A+ ++S
Sbjct: 1512 KQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAK----DSALQSI 1567
Query: 106 ENELDPLKNRLKEIEHNLSKIMKLDNEIK----ALDSRKKQMEKDNSELEEKM----EKV 157
E+++ L NRL+E + + ++K E+K AL + Q++++ E+ KM EK
Sbjct: 1568 ESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKE 1627
Query: 158 FQ--------GTDEQLNDLYHNHQRTVREK------ERKLVDCHRELEKLNKESRLLNQE 203
+Q T E++ ++ H ++ +K E + + + L + +E R + +E
Sbjct: 1628 YQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKE 1687
Query: 204 KSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFE-------------RGPFS 250
+ +L + L+++ D+ +E++ R+++ + L Q EL RG S
Sbjct: 1688 RDDLRSVEETLKVERDQLKENL--RETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVS 1745
Query: 251 ER--QIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKS 308
E+ +I N K + E K + + + + K+ E DK G I+ K+
Sbjct: 1746 EKTNEISNMQKDL-EHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRG---IVSEKT 1801
Query: 309 EILSKKQNELKN----VKYELQQLEGSSDRILELDQELIKAERELSKAEK-NSNVETLKM 363
+ LS Q +L+N ++ ++Q+L+ + +++ L +++ + ++++S+ E+ ++ +
Sbjct: 1802 DKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSL 1861
Query: 364 EVISLQNEKADLDRTLRKLDQEMEQ-LNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSD 422
+ L+ E +L + L + +EM+ + R E L ++ E +++ K+R +
Sbjct: 1862 TLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLE 1921
Query: 423 ELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQ 482
L K+ ++ + ++I++ +++ + K+L S+ EL++KE Q
Sbjct: 1922 IQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQ 1981
Query: 483 LSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCC 542
L ++ DV S +++++LK++ E + L+ + F QLT +
Sbjct: 1982 LLRVKE---DVNMSHKKINEMEQLKKQFEAQN-----LSMQSVRMDNF--QLTKKLHESL 2031
Query: 543 PVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIID 602
+ V + EL+ + + L++ D+ +T E+ ++++ + + P ++ + D
Sbjct: 2032 EEIRIVAKERDELRRI----KESLKMERDQFIATLREMIARDRQNHQ---VKPEKRLLSD 2084
Query: 603 LKEKEIPELRNKLQNVNRDIQR-----------------LKNDIEEQETLLGTI-----M 640
++ LR K + ++R L+ +IE Q+ L + +
Sbjct: 2085 GQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSL 2144
Query: 641 PEEESAKV---------CLTDV-TIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVN 690
P ++ + C + IM++ + L V + +Q + ++D + +V
Sbjct: 2145 PYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMD-FIDEVE 2203
Query: 691 QEK------QEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNE-----LKSEKLQIS 739
++K Q Q D S ++ + KL Q+ I+ + +E +K+E Q+
Sbjct: 2204 KQKELLIKIQHLQQDCDVPSRELR-DLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVL 2262
Query: 740 TNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEK----FQQEKEELINKKN 795
+N + Q E+ + +++ L I+ +++ + E E +
Sbjct: 2263 SNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSA 2322
Query: 796 TSNKIAQDKLNDIKEKVKNIHGYMKDIENYI----------QDGKDDYKKQKET------ 839
T +K + L +KEK + + + ++ + QD K+ + + T
Sbjct: 2323 TISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEK 2382
Query: 840 --ELNKVIAQLSECEKHKE----KINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELK 893
EL + + E HKE K+ +++ + I K+Q + + N L K E ++
Sbjct: 2383 IRELENSLHEAKESAMHKESKIIKMQKELEVTNDII--AKLQAKVHESNKCLEKTKETIQ 2440
Query: 894 EVEEE----RKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHF 949
++++ K + +E+ +++ +K + +K+ +N ++ + A Y++E+I
Sbjct: 2441 VLQDKVALGAKPYKEEIEDLKMKLVKIDLEKM-KNAKEFEKEIS-ATKATVEYQKEVIRL 2498
Query: 950 KKE-LREPQ 957
+E LR Q
Sbjct: 2499 LRENLRRSQ 2507
Score = 102 bits (254), Expect = 2e-21
Identities = 185/913 (20%), Positives = 399/913 (43%), Gaps = 165/913 (18%)
Query: 176 VREKERKLVDCHRELEKLNKESRLLNQEK---SELLVEQGRLQLQADRHQEHIRARDSLI 232
++ ++++D ++LE+++ E+R EK ++LL E+ LQ + E++
Sbjct: 345 LKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTS 404
Query: 233 QSLATQLELDGFER-------GPFSERQIKNF--------------HK----LVRERQE- 266
SL Q EL + G ++ + N+ HK L+RE E
Sbjct: 405 SSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDES 464
Query: 267 --GEAKTANQLMNDFAEKE------TLKQKQID-EIRDKKTGLGRII----ELKSEILSK 313
E+ + ++ +E E L Q+ I+ E+ + ++ +L++E K
Sbjct: 465 VCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTE---K 521
Query: 314 KQNELK-NVKYELQQLEGSSDRILELDQE------------LIK--------AERELSK- 351
++ ELK K +L + E + +R + DQE L+K E ELS
Sbjct: 522 EEMELKLKEKNDLDEFE-ALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSK 580
Query: 352 ----AEKNSNVETLKMEVIS--LQNEKADLDRTLRKLD--QEMEQLNHHTTT-----RTQ 398
EK ++ L+ + S L+N K DL +L ++ ++M+Q T + +
Sbjct: 581 VELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRE 640
Query: 399 MEMLTKDKADKDEQIRKIKSRH---SDELTSLLGYFPNKKQ----LEDWLHSKSKEINQT 451
L + + E+++++ + + +++ KK+ LE L S EI +
Sbjct: 641 SAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKL 700
Query: 452 RDRL-AKLNKELASS---EQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLK 507
+ K+ K+L + E + EL ++ E+ + +++ + + S+++RL+
Sbjct: 701 TSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLR 760
Query: 508 EEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVIS------- 560
+EI+ S++ ++ T+ + +++ + + + + +T+ +L S
Sbjct: 761 KEIQDKSEELHII---TSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQ 817
Query: 561 ----------DLQSKLRLAPDKLKSTESE---LKKKEKRRDEMLGLVPMRQSIIDLKEKE 607
D + K ++ ++ + E L K+ ++ D LG + ++ + K +E
Sbjct: 818 EFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGAL---KTELSYKTQE 874
Query: 608 IPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEE----ESAKVCLTDVTIMERFQMEL 663
+ E ++Q ++++LK +E +++ L T+ E+ E + L +V + + + +L
Sbjct: 875 LQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDL 934
Query: 664 KDVERKIAQQAAKLQ-------GIDLDRTVQQVNQEKQEKQHK--LDTVSSKI--ELNRK 712
K ++ + + +L+ +++D Q N + KQH+ ++T+ SKI E++R
Sbjct: 935 KQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRN 994
Query: 713 LIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELST------EVQSLYREI 766
L H++ T E K E Q + ++Q LE + + T E+ R+I
Sbjct: 995 L---------HMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKI 1045
Query: 767 KDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYI 826
++ + L+ LE EKE+L T K + + +E+++ + +K + +
Sbjct: 1046 FSLIQEKNELQQMLESVIAEKEQL----KTDLKENIEMTIENQEELRLLGDELKKQQEIV 1101
Query: 827 QDGKDDYKKQKETELNKVIAQLSEC-EKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTL 885
K ++ +KE EL++ +L+E EK KEK + +Q ++ Q ++ +
Sbjct: 1102 AQEK-NHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQ-------EEMSEM 1153
Query: 886 RKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIK---RNHNLALGRQKGY 942
+K+ E++ ++ E K + M+ +++ QKL EN + +K + + QK +
Sbjct: 1154 QKKINEIENLKNELKNKELTLEHMETERLELA-QKLNENYEEVKSITKERKVLKELQKSF 1212
Query: 943 EEEIIHFKKELRE 955
E E H + +RE
Sbjct: 1213 ETERDHLRGYIRE 1225
Score = 93.2 bits (230), Expect = 1e-18
Identities = 175/851 (20%), Positives = 372/851 (43%), Gaps = 124/851 (14%)
Query: 4 SLGVSKAVLNNVIFCHQEDSNWPLSEGKALKQKFDEIFSATRYIKA-LETLRQVRQTQGQ 62
SL +SK + N+ + N L E K++ ++ D + +K + L++ Q
Sbjct: 1860 SLTLSKLEIENLNLAQKLHEN--LEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKA 1917
Query: 63 KVKEYQMELKYL----KQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKE 118
+ E Q ELK K++KE ++R++I+ K Q++ +I K + D L+ +++E
Sbjct: 1918 RDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQIS---DIQKDLDKSKDELQKKIQE 1974
Query: 119 IEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDL-YHNHQRTVR 177
++ +++++ ++ + +ME+ ++K F+ + + + N Q T
Sbjct: 1975 LQKKELQLLRVKEDVNMSHKKINEMEQ--------LKKQFEAQNLSMQSVRMDNFQLT-- 2024
Query: 178 EKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLAT 237
+KL H LE++ R++ +E+ EL + L+++ D Q +AT
Sbjct: 2025 ---KKL---HESLEEI----RIVAKERDELRRIKESLKMERD-------------QFIAT 2061
Query: 238 QLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKK 297
E+ +R Q+K +L+ + Q+ ++ + + KE LK+ E+ D
Sbjct: 2062 LREMIARDR---QNHQVKPEKRLLSDGQQHLTESLREKCSRI--KELLKR--YSEMDDHY 2114
Query: 298 TGLGRI-IELKSEILSKKQNELK-----NVKY----ELQQLEGSSDRI-LELDQELIKAE 346
L R+ ++L+ EI +K+ ++ ++ Y +++L ++ R +E + + K +
Sbjct: 2115 ECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLK 2174
Query: 347 RELS-----KAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQ-------EMEQLNHHTT 394
LS K E++ ++ +M+ I ++ +L ++ L Q E+ L +
Sbjct: 2175 YVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQN 2234
Query: 395 TRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQ----LEDWLHSKSKEINQ 450
+E + KD ++ + IK+ L+ N+K+ LE+WL+++ +I +
Sbjct: 2235 MDLHIEEILKDFSESE--FPSIKTEFQQVLS-------NRKEMTQFLEEWLNTRF-DIEK 2284
Query: 451 TRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEI 510
++ + K N + Q N NN + + + +E++ + S+++E DL LKE+
Sbjct: 2285 LKNGIQKENDRIC---QVNNFFNNRIIAIMNESTEFEERSATI--SKEWEQDLKSLKEKN 2339
Query: 511 EKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAP 570
EK K L + A +Q + T +N++ V R Q E I +L++ L A
Sbjct: 2340 EKLFKNYQTLKTSLASGAQ-VNPTTQDNKNP-HVTSRATQLTTEK---IRELENSLHEAK 2394
Query: 571 DKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIE 630
+ ES++ K +K +++ I +L+ K+ N+ +++ K I+
Sbjct: 2395 ESAMHKESKIIKMQKE--------------LEVTNDIIAKLQAKVHESNKCLEKTKETIQ 2440
Query: 631 --EQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQ 688
+ + LG +EE + + V I K+ E++I+ A ++ + +
Sbjct: 2441 VLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLR 2500
Query: 689 VNQEKQEKQHKLDTVSSKIE---LNRKLIQDQQEQI-QHLKSTTNELKSEKLQISTNLQR 744
N + ++ +S + N+ L I Q+ K+ LKSE +++ + +
Sbjct: 2501 ENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALI--LKSEHIRLEKEISK 2558
Query: 745 RQQLEEQTVELSTEV----QSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKI 800
+Q EQ ++ E+ Q L E+K KE+ E + + + T++K
Sbjct: 2559 LKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTASKK 2618
Query: 801 AQDKLNDIKEK 811
Q + KE+
Sbjct: 2619 KQITPSQCKER 2629
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 134 bits (338), Expect = 4e-31
Identities = 195/988 (19%), Positives = 440/988 (44%), Gaps = 113/988 (11%)
Query: 84 IRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSK-----------IMKLDNE 132
+RDQ+ E +LT ++ EL L+ +L + + SK +M+L
Sbjct: 1262 LRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHET 1321
Query: 133 IKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKL--------- 183
+ +L SR ++ E E + + E + Q E L + Q V E +
Sbjct: 1322 MASLQSRLRRAELQRMEAQGERE-LLQAAKENLTAQVEHLQAAVVEARAQASAAGILEED 1380
Query: 184 VDCHRELEKLNKESRLLNQEKSELLVEQGRLQL-QADRHQEHIRARDSLIQSLATQLELD 242
+ R KL E +E+++ L EQG L++ Q QE++ L Q+LA + E
Sbjct: 1381 LRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLAL---LTQTLAEREEEV 1437
Query: 243 GFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGR 302
RG E + + RE Q+ + + + ++ L+Q+QI E+ ++
Sbjct: 1438 ETLRGQIQELEKQ------REMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRS---- 1487
Query: 303 IIELKSEILSKKQNELKNVKYELQQLEGSSDRILE---LDQELIKAERELSKAE-KNSNV 358
++E + +++ +L + ++++LE DR + L+ +L++ E++ E + V
Sbjct: 1488 VLEHLPMAVQEREQKLTVQREQIRELE--KDRETQRNVLEHQLLELEKKDQMIESQRGQV 1545
Query: 359 ETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTR-TQMEMLTKDKADKDEQIRKIK 417
+ LK ++++L+ +L+ K++ + + + R TQ LT D +E+ ++++
Sbjct: 1546 QDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQ 1605
Query: 418 SRHSD--ELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNE 475
++ S +L S + L L + +E+ R+++ +L ++ Q+ + E
Sbjct: 1606 AQSSQIHDLES------HSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQE 1659
Query: 476 LKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLT 535
L ++E++ ED+ ++ E DL+++K + + ++ Q + +
Sbjct: 1660 LMLQKERIQVLEDQR--TRQTKILEEDLEQIKLSLRERGRE-------LTTQRQLMQERA 1710
Query: 536 DENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVP 595
+E + + + ++ ++ D + ++ + + + + E++ + V
Sbjct: 1711 EEGKGPSKAQRGSLE---HMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVG 1767
Query: 596 MRQSIIDLKEKEIPELRNKLQNVNRD----IQRLKNDIEEQETLLGTIMPEEESAKVCLT 651
++ +E+EI L+ +LQ Q L++ ++E + L E E+
Sbjct: 1768 ETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEA------ 1821
Query: 652 DVTIMERFQMELKDVERKIAQQAAKLQGI--DLDRTVQQVNQEKQEKQHKLDTVSSKIEL 709
+++ Q + + E ++ ++A LQG T+++ + E Q+ + + + ++ +
Sbjct: 1822 ----LQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAV 1877
Query: 710 NRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDA 769
+ +Q +E + L++ + E + L + +QQ EQ E E ++L A
Sbjct: 1878 EGRRVQALEEVLGDLRAESREQEKALLAL------QQQCAEQAQEHEVETRALQDSWLQA 1931
Query: 770 KEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDG 829
+ + + LE + E + +++ A+ + ++E + H ++ E ++ +
Sbjct: 1932 QAVLKERDQELEALRAESQSSRHQEEA----ARARAEALQEALGKAHAALQGKEQHLLE- 1986
Query: 830 KDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKI--QERWLQDNLTLRK 887
+ + + E + A L C+ H ++ E +R+ +I Q + QE Q L +
Sbjct: 1987 QAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQ 2046
Query: 888 RNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEII 947
R+EEL+ ++ER+Q L+ KS Q+++EN+ K+N LG+++ EEEI
Sbjct: 2047 RDEELRH-QQEREQLLE----------KSLAQRVQENMIQEKQN----LGQER-EEEEIR 2090
Query: 948 HFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEIN-K 1006
+ +RE Q A+++ + ++ +R T+ N +L+ + + M+ S+K++ + +
Sbjct: 2091 GLHQSVRELQLTLAQKE--QEILELRETQQRN-NLEALPHSHKTSPMEEQSLKLDSLEPR 2147
Query: 1007 IIRDLWR--STYRGQDIEYIEIRSDADE 1032
+ R+L R + R + IE R A +
Sbjct: 2148 LQRELERLQAALRQTEAREIEWREKAQD 2175
Score = 121 bits (304), Expect = 3e-27
Identities = 205/1055 (19%), Positives = 428/1055 (40%), Gaps = 171/1055 (16%)
Query: 51 ETLRQVRQTQGQKVKEYQMELKYLKQYKEKAC----EIRDQITSKEAQLTSSKEIVKSY- 105
E+L +V +++ + K L++ EK RD++ KE+Q +E K Y
Sbjct: 111 ESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYL 170
Query: 106 ENELDPLKNRLKEI----EHNLSKIMKLDN---EIKA----------------------- 135
+ E L + +E+ H L D E+KA
Sbjct: 171 KGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSR 230
Query: 136 -------LDSRK-----------KQMEKDNSELEEKMEKVFQGTD---EQLNDLYHNHQR 174
+D R+ +++EK+ E +++ ++ D +L D
Sbjct: 231 EPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSA 290
Query: 175 TVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQS 234
+ + +++ D + ++ L + +L +EL+ + L A QE + +I+
Sbjct: 291 LLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNA---QEEKLSLQQVIKD 347
Query: 235 LATQL--ELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDE 292
+ + E D +G E ++ + + +A A L+ T +++ + +
Sbjct: 348 ITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVL---TRRRQAVQD 404
Query: 293 IRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKA 352
+R + G + L + + + E K ++ LQ+L G D + +L
Sbjct: 405 LRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDL---------- 454
Query: 353 EKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQ 412
V++L E LQ + +L + L L+QE +L R +E+ + + + +
Sbjct: 455 --QGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLR-----RVNVELQLQGDSAQGQ- 506
Query: 413 IRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHI 472
K +EL + +++L++ L + +++ L L + L SS H+
Sbjct: 507 ----KEEQQEELHLAV---RERERLQEMLMGLEAKQSESLSELITLREALESS-----HL 554
Query: 473 NNELKRKEE-----QLSSYEDKLFDVCGSQD-FESDLDRLKEEIEKSSKQRAMLAGATAV 526
EL R+E+ L+ E + ++ S++ ++++ L+ K S LA
Sbjct: 555 EGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVG 614
Query: 527 YSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKR 586
+Q + QL +ENQS C + Q LQ +++ + + +K E++L+K E+
Sbjct: 615 LNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEA 674
Query: 587 RDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESA 646
E+ + Q + +K++ E R++ + +++L + + QE +L + E+E+
Sbjct: 675 GAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEAL 734
Query: 647 KVCLTDVTIMERFQMELKDVERKIAQQAAKLQGI-------------------------- 680
V ++ L+ VER A +LQG+
Sbjct: 735 ------VREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKG 788
Query: 681 DLDRTVQQVNQEKQEKQH-------KLDTVSSKIELN-----RKLIQDQQEQIQHLKSTT 728
L+ +Q V Q K+ Q +LDT S+ E R+L Q +QE L+
Sbjct: 789 QLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQK 848
Query: 729 NELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKE 788
+ E Q+ ++ + +Q EL+ ++SL RE + + ++ +T +E Q ++E
Sbjct: 849 AAHEKEVNQLREKWEKERSWHQQ--ELAKALESLEREKMELEMRLKEQQTEMEAIQAQRE 906
Query: 789 ELINKKNTSNKIAQDKLNDIKEKVKNIHGYMK------DIENYIQDGKDDYKKQKETELN 842
E + + + Q +L KE+V + ++ D ++ + D K QK E
Sbjct: 907 E--ERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQE 964
Query: 843 KVIAQLSECEKHKEKINEDMRLMRQDIDT-QKIQERWLQDNLTLRKRNEELKE--VEEER 899
++ ++ + ++ E R R D+ Q+ LQD + L+K+ E+LK V ++
Sbjct: 965 TTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDD 1024
Query: 900 KQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKG-----------YEEEIIH 948
Q L E + L+ E+ ++++ ++ K + L+L ++ ++E+
Sbjct: 1025 SQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSA 1084
Query: 949 FKKELREPQFRDAEEKYREMMIVMRTTELVNKDLD 983
+++++E Q E+K + + E+ K+ D
Sbjct: 1085 LRQDMQEAQ---GEQKELSAQMELLRQEVKEKEAD 1116
Score = 119 bits (299), Expect = 1e-26
Identities = 239/1265 (18%), Positives = 519/1265 (41%), Gaps = 220/1265 (17%)
Query: 48 KALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYEN 107
KALE+L + + ++KE Q E++ ++ +E E R Q S Q+
Sbjct: 875 KALESLEREKMELEMRLKEQQTEMEAIQAQRE---EERTQAESALCQM------------ 919
Query: 108 ELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLND 167
+L+ K R+ +E L Q +K+ ++ +++E++ Q D ++
Sbjct: 920 QLETEKERVSLLETLL------------------QTQKELADASQQLERLRQ--DMKVQK 959
Query: 168 LYHNHQRTVREKERKLVDCHRELEKLNKESR----LLNQEKSELLVEQGRLQLQADRHQE 223
L Q T + +L + REL++ ++ R L +E S LL ++ LQ Q + +
Sbjct: 960 L--KEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKS 1017
Query: 224 HIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKE 283
+ A+D + + +++ R+ + ++++ +E + +A LM E+
Sbjct: 1018 QLVAQDDSQRLVEQEVQE--------KLRETQEYNRIQKELEREKASLTLSLMEK--EQR 1067
Query: 284 TLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELI 343
L ++ D IR ++ R + + + Q E K + +++ L + E + + +
Sbjct: 1068 LLVLQEADSIRQQELSALR------QDMQEAQGEQKELSAQMELLR---QEVKEKEADFL 1118
Query: 344 KAERELSKAEKNSNV--ETLKMEVISLQNEKADLDRTLRKLDQEMEQL------NHHTTT 395
E +L + + S++ + L+ + + + + A L LR + ++E L +
Sbjct: 1119 AQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQA 1178
Query: 396 RTQMEML---TKDKADKDEQIRKIKSRHSDELTSLLGYFPNK------------------ 434
+ Q+ L + + R S D S+ G P++
Sbjct: 1179 QAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSA 1238
Query: 435 KQLEDWLHSKSKEINQT-------RDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYE 487
+ + LH +++ +T RD++ KL + L +E K+ ++ EL+ + QLS +
Sbjct: 1239 EAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQ 1298
Query: 488 DKLFDVCGSQD-FESDLDRLKEEIE--KSSKQRAMLAGATAVYSQFITQLTDENQSCCPV 544
++ G Q+ ES+L L E + +S +RA L A + + Q EN +
Sbjct: 1299 EEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVE 1358
Query: 545 CQRVFQTEAELQEVISD-LQSKLRLAPDKLKSTESELKKKEKRRDEML------------ 591
+ EA Q + L+ LR A LK E++ + +R +
Sbjct: 1359 HLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKA 1418
Query: 592 ---GLVPMRQSIIDLKEKEIPELRNKLQNVNRD-------IQRLKNDIEEQETLLGTIMP 641
L + Q++ + +E+E+ LR ++Q + + ++ L D++++ +
Sbjct: 1419 LQENLALLTQTLAE-REEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQE 1477
Query: 642 EEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQ----EKQ 697
+ + + C + ++E M +++ E+K+ Q +++ ++ DR Q+ E Q EK+
Sbjct: 1478 QIQELEKCRS---VLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKK 1534
Query: 698 HK------------------LDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQIS 739
+ L+ ++ ++E N ++ QQ+ I+ L+ + ++
Sbjct: 1535 DQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLT 1594
Query: 740 TNLQRRQQ-----------LEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKE 788
+L+ R Q LE + L+ E+Q +E+K +EQ+ L+ E Q+ E
Sbjct: 1595 LDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLE 1654
Query: 789 E--------------LINKKNTSNKIAQDKLNDIK----EKVKNIHGYMKDIENYIQDGK 830
L +++ KI ++ L IK E+ + + + ++ ++GK
Sbjct: 1655 RRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGK 1714
Query: 831 DDYKKQK-ETELNKVIA--QLSECEKHKEKINEDMRLMRQ-DIDTQKIQERWLQDNLTLR 886
K Q+ E K+I + E E +E I+E L Q + Q + + + +L L
Sbjct: 1715 GPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLS 1774
Query: 887 KRNEEL----KEVEEERKQ-HLKEMG-QMQVLQMKSEHQKLEENIDNIKRNHNLALGRQK 940
+R +E+ ++++E R+Q LKE Q Q+ + + + ++ ++ +++ A G+++
Sbjct: 1775 QREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEE 1834
Query: 941 GYEE---------EIIHFKKELREPQFRDAEEKYR----EMMIVMRTTELVNK---DLDI 984
+E E H + R + +D +E+ R E+ + R + + + DL
Sbjct: 1835 RVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRA 1894
Query: 985 YYKTLDQAIMKFHSMKMEEI------NKIIRDLWRSTY-----RGQDIEYIEIRSDADEN 1033
+ ++A++ E+ + ++D W R Q++E + S + +
Sbjct: 1895 ESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRH 1954
Query: 1034 VSASDKRRNYNYRVVMLKGDTALDMRGRCSAGQKVLASLIIRLALAETFCLNCGIIALDE 1093
+ + R + + K AL + + Q L+ R A T L + A
Sbjct: 1955 QEEAARARAEALQEALGKAHAALQGKEQHLLEQAELS----RSLEASTATLQASLDACQA 2010
Query: 1094 PTTNLDRENIESLAHALVEIIKSRSQQRNFQLLVITHDEDFVELLGRSEYVEK--FYRIK 1151
+ L+ + ++ + + Q + DE+ R + +EK R++
Sbjct: 2011 HSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQ 2070
Query: 1152 KNIDQ 1156
+N+ Q
Sbjct: 2071 ENMIQ 2075
Score = 111 bits (277), Expect = 5e-24
Identities = 191/938 (20%), Positives = 393/938 (41%), Gaps = 103/938 (10%)
Query: 89 TSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNS 148
T EAQL ++E + +L ++ +EI+ LS+ ++ +A ++ +Q+ ++
Sbjct: 662 THLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESR---HQQEAATTQLEQLHQEAK 718
Query: 149 ELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLL-------N 201
EE + + Q + + + R ++ ER D +L+ L+ LL
Sbjct: 719 RQEEVLARAVQEKEALVREKAALEVR-LQAVERDRQDLAEQLQGLSSAKELLESSLFEAQ 777
Query: 202 QEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLV 261
Q+ S + V +G+L++Q + ++ L +LELD ER + + +L
Sbjct: 778 QQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCL--KLELD-TERSQAEQERDAAARQLA 834
Query: 262 RERQEGEA----------KTANQLMNDFAEKETLKQKQIDEI-----RDKKTGLGRIIEL 306
+ QEG+ K NQL + ++ + Q+++ + R+K R+ E
Sbjct: 835 QAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQ 894
Query: 307 KSE---ILSKKQNELKNVKYEL--QQLEGSSDRI------LELDQELIKAERELSKAEKN 355
++E I ++++ E + L QLE +R+ L+ +EL A ++L + ++
Sbjct: 895 QTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQD 954
Query: 356 SNVETLKMEVIS------LQNEKADLDRTLRKLDQEMEQLNHHTTT--------RTQMEM 401
V+ LK + + LQ + +L R+ ++ L +++ + Q+E
Sbjct: 955 MKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVED 1014
Query: 402 LTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKL--- 458
L +D+ R ++ ++L Y +K+LE S + + + RL L
Sbjct: 1015 LKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEA 1074
Query: 459 ----NKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKS- 513
+EL++ Q+ E K Q+ ++ + DF + +L EE+E S
Sbjct: 1075 DSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKE--KEADFLAQEAQLLEELEASH 1132
Query: 514 ---SKQRAMLAGATAVYSQFITQL-TDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLA 569
+ RA L A +Q +L + E+Q ++ +A+ Q ++ L S L+ A
Sbjct: 1133 ITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQA 1192
Query: 570 PDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDI 629
+ + EL + GL P + L ++ + V + +L D+
Sbjct: 1193 LGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDL 1252
Query: 630 EEQETLLGTIMPEEESAKVCLTDVTIMERFQM--ELKDVERKIAQ-QAAKLQGIDLDRTV 686
+ + + + + + LTD T E+ Q+ EL+D++R+++Q Q K + ++
Sbjct: 1253 WKTQQTRDVLRDQVQKLEERLTD-TEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSL 1311
Query: 687 QQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQE-----------QIQHLKSTTNELKSEK 735
+ E E L + + EL R Q ++E Q++HL++ E +++
Sbjct: 1312 ESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQ- 1370
Query: 736 LQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKN 795
+ L+ + ++L E RE A ++ L+ K QE L+ +
Sbjct: 1371 ASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQ-- 1428
Query: 796 TSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGK--------DDYKKQKETEL-NKVIA 846
L + +E+V+ + G ++++E + K D K+ +E +L + I
Sbjct: 1429 --------TLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQ 1480
Query: 847 QLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEM 906
+L +C E + ++ Q + Q+ Q R L+ + ++ E + +E E+K + E
Sbjct: 1481 ELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIES 1540
Query: 907 GQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEE 944
+ QV +K + LE ++ NH+ +QK +E
Sbjct: 1541 QRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKE 1578
Score = 107 bits (268), Expect = 5e-23
Identities = 192/959 (20%), Positives = 391/959 (40%), Gaps = 185/959 (19%)
Query: 32 ALKQKFDEIFSATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSK 91
ALK K +E+ S +AL+ +++ QG+ ++E
Sbjct: 1387 ALKLKNEEVESERERAQALQEQGELKVAQGKALQE------------------------- 1421
Query: 92 EAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELE 151
L + + E E++ L+ +++E+E ++ K E+ +LD +K+ E D +
Sbjct: 1422 --NLALLTQTLAEREEEVETLRGQIQELEKQ-REMQKAALELLSLDLKKRNQEVDLQ--Q 1476
Query: 152 EKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNK---------ESRLLNQ 202
E+++++ E+ + + V+E+E+KL ++ +L K E +LL
Sbjct: 1477 EQIQEL-----EKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLEL 1531
Query: 203 EKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVR 262
EK + ++E R Q+Q ++ + ++ LA +LE + +++ KL++
Sbjct: 1532 EKKDQMIESQRGQVQ------DLKKQLVTLECLALELE--------ENHHKMECQQKLIK 1577
Query: 263 E---RQEGEAKTANQLMNDFAEKETLKQKQIDEIRD---KKTGLGR-IIELKSEILSKKQ 315
E ++E + L D E+ Q Q +I D T L R + E E+ S+++
Sbjct: 1578 ELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQRE 1637
Query: 316 --NELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKA 373
EL+ K L Q D+ L L +E I+ + + E L+ +SL+
Sbjct: 1638 QIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGR 1697
Query: 374 DLDRTLRKLDQEM--EQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYF 431
+L T R+L QE E R +E + DK++++ + + H EL L
Sbjct: 1698 EL-TTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEV-ECQQEHIHELQEL---- 1751
Query: 432 PNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLF 491
K QLE L +++ +T L++ +E+ +Q + + KE+ L S D+
Sbjct: 1752 --KDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQ 1809
Query: 492 DVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQT 551
+D +L+ L++E +++ Q
Sbjct: 1810 RALAQRD--QELEALQQEQQQAQGQ----------------------------------- 1832
Query: 552 EAELQEVISDLQSKLRLAPDKLKSTESEL---KKKEKRRDEMLGLVPMRQSIIDLKEKEI 608
E ++E LQ L A LK EL K++ +R +E L + R + E+ +
Sbjct: 1833 EERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRR---VQALEEVL 1889
Query: 609 PELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVE- 667
+LR + + + + L+ EQ E E L D + + ++ +D E
Sbjct: 1890 GDLRAESREQEKALLALQQQCAEQ-------AQEHEVETRALQDSWLQAQAVLKERDQEL 1942
Query: 668 ---------RKIAQQAAKLQGIDLDRTVQQVNQEKQEK-QHKLDTVSSKIELNRKLIQDQ 717
+ ++AA+ + L + + + Q K QH L+ + EL+R L
Sbjct: 1943 EALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLE----QAELSRSL---- 1994
Query: 718 QEQIQHLKSTTNELKSEKLQISTNLQRRQ-QLEEQTVELSTEVQSLYREIKDAKEQVSPL 776
+ L+++ + ++ Q+ L+ ++ ++++Q + +VQ L + + E++
Sbjct: 1995 EASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEEL--- 2051
Query: 777 ETTLEKFQQEKEELINK---KNTSNKIAQDKLN----DIKEKVKNIHGYMKDIENYIQDG 829
+ QQE+E+L+ K + + Q+K N +E+++ +H +++++ +
Sbjct: 2052 -----RHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQK 2106
Query: 830 KDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRN 889
+ + + +ET+ + L K + ++L + Q+ ER L R
Sbjct: 2107 EQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELER-----LQAALRQ 2161
Query: 890 EELKEVEEERK------------------QHLKEMGQMQVLQMKSEHQKLEENIDNIKR 930
E +E+E K Q + Q VL+ SE Q+L++ ++ +R
Sbjct: 2162 TEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRR 2220
Score = 100 bits (248), Expect = 1e-20
Identities = 177/937 (18%), Positives = 379/937 (40%), Gaps = 113/937 (12%)
Query: 132 EIKALDSRKKQMEKDNSELEEKMEKVFQGTD---EQLNDLYHNHQRTVREKERKLVDCHR 188
++ L ++ +++EK+ E +++ ++ D +L D + + +++ D +
Sbjct: 245 QLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEK 304
Query: 189 ELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQL--ELDGFER 246
++ L + +L +EL+ + L A QE + +I+ + + E D +
Sbjct: 305 MIKALRETVEILETNHTELMEHEASLSRNA---QEEKLSLQQVIKDITQVMVEEGDNIAQ 361
Query: 247 GPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIEL 306
G E ++ + + +A A L+ T +++ + ++R + G + L
Sbjct: 362 GSGHENSLELDSSIFSQFDYQDADKALTLVRSVL---TRRRQAVQDLRQQLAGCQEAVNL 418
Query: 307 KSEILSKKQNELKNVKYELQQLEGSSDRI------LELDQELIKAEREL---SKAEKNSN 357
+ + + E K ++ LQ+L G D + L+ + + + EREL ++ E
Sbjct: 419 LQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQ 478
Query: 358 VETLKMEVISLQNEKADL----DRTLRKLDQEMEQLNHHTTTRTQM-EMLTKDKADKDEQ 412
+E L+ E L+ +L D + +++ E+L+ R ++ EML +A + E
Sbjct: 479 LEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSES 538
Query: 413 IRK-IKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNH 471
+ + I R + E + L G + L + E+ R + EL+SSE
Sbjct: 539 LSELITLREALESSHLEG---------ELLRQEQTEVTAALARAEQSIAELSSSENTLKT 589
Query: 472 INNELKRKEEQLSSYEDKL-FDVCGSQD----FESDLDRLKEEIEKSSKQRAMLAGATAV 526
+L+ +LS+ + L D G E + + +E + + R L A
Sbjct: 590 EVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAE 649
Query: 527 YSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTE--------- 577
+ L ++N Q+ + AELQ + D+Q + KL +
Sbjct: 650 AEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQ 709
Query: 578 -SELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIE----EQ 632
+L ++ KR++E+L + + ++EK E+R LQ V RD Q L ++ +
Sbjct: 710 LEQLHQEAKRQEEVLARAVQEKEAL-VREKAALEVR--LQAVERDRQDLAEQLQGLSSAK 766
Query: 633 ETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQE 692
E L ++ ++ V +E Q++ +++ Q + ++LD Q QE
Sbjct: 767 ELLESSLFEAQQQNSVIEVTKGQLE-VQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQE 825
Query: 693 KQE----------------KQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKL 736
+ +Q K +L K +++ Q L L+ EK+
Sbjct: 826 RDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKM 885
Query: 737 QISTNLQRRQ--------------------------QLEEQTVELSTEVQSLYREIKDAK 770
++ L+ +Q + E++ V L + +E+ DA
Sbjct: 886 ELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADAS 945
Query: 771 EQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGK 830
+Q+ L ++ + +++E T + AQ +L + + ++ +++ + + K
Sbjct: 946 QQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDK 1005
Query: 831 DDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNE 890
D +KQ E ++++AQ ++++ E +R ++ QK ER + +LTL +
Sbjct: 1006 MDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELER-EKASLTLSLMEK 1064
Query: 891 E-----LKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHN------LALGRQ 939
E L+E + R+Q L + Q + + + E ++L ++ +++ LA Q
Sbjct: 1065 EQRLLVLQEADSIRQQELSALRQ-DMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQ 1123
Query: 940 KGYEEEIIHFKKELREPQFRDAEEKYREMMIVMRTTE 976
E E H ++ E K ++ + +R+TE
Sbjct: 1124 LLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTE 1160
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 134 bits (338), Expect = 4e-31
Identities = 204/1065 (19%), Positives = 434/1065 (40%), Gaps = 182/1065 (17%)
Query: 63 KVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENEL--------DPLKN 114
K E + E+ +K+ EK E + +K +L + +N+L D L +
Sbjct: 845 KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLAD 904
Query: 115 RLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQR 174
+ + + ++L+ +IK + R + E+ N+EL K K+ E D+ + +
Sbjct: 905 AEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDI-DDLEL 963
Query: 175 TVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQS 234
T+ + E++ +++ L +E L++ ++L E+ LQ + + ++A + + +
Sbjct: 964 TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNT 1023
Query: 235 LAT-----QLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQ 289
L + ++D E E++I+ + + + EG+ K A + D + ++
Sbjct: 1024 LTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEK 1083
Query: 290 IDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAER-E 348
+ + + +GL IE + + + Q ++K ++ +++LE E I+AER
Sbjct: 1084 LKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELE-----------EEIEAERAS 1132
Query: 349 LSKAEKNSNVETLKMEVISLQ--------------NEKADLDRTLRKLDQEMEQLNHHTT 394
+KAEK + + ++E IS + N+K + + + D E L H T
Sbjct: 1133 RAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEAT 1192
Query: 395 TRTQMEMLTKDKADKDEQI---RKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQT 451
T + A+ EQI +++K + E + + K +++D L S + +++
Sbjct: 1193 AATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEM------KMEIDD-LASNMETVSKA 1245
Query: 452 RDRLAKLNK-------ELASSEQNKNHINNELKRKEEQLSS----YEDKLFD-------- 492
+ L K+ + E+ + E+ + + N+L + +L + Y +L +
Sbjct: 1246 KGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQL 1305
Query: 493 VCGSQDFESDLDRLKEEIEKSSKQRAMLAGA---TAVYSQFITQLTDENQSCCPVCQRV- 548
G Q F ++ LK ++E+ K ++ LA A + + + +E Q QR
Sbjct: 1306 SRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAM 1365
Query: 549 -------------FQTEA-----ELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEM 590
++T+A EL+E L +L+ A + +++ ++ EK + +
Sbjct: 1366 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRL 1425
Query: 591 LGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKV-- 648
V ++ L K +N ++ + K EE L E S
Sbjct: 1426 QNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTEL 1485
Query: 649 ---------CLTDVTIMER----FQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQE 695
L + ++R Q E+ D+ +IA+ ++ +L++ +QV QEK E
Sbjct: 1486 FKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIH--ELEKIKKQVEQEKSE 1543
Query: 696 KQHKLDTVSS-------------------KIELNRKLIQDQQE----------QIQHLKS 726
Q L+ + K E++RK+ + +E ++ ++S
Sbjct: 1544 LQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQS 1603
Query: 727 TTN-ELKSEKLQISTNLQRRQQLEEQTVELS------------------------TEVQS 761
T + E++S I + L E ++L+ +
Sbjct: 1604 TLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDD 1663
Query: 762 LYREIKDAKEQVSPLETTLEKFQQEKEEL---INKKNTSNKIAQDKLNDIKEKVKNIHGY 818
R +D KEQ++ +E Q E EEL + + S KIA+ +L D E+V+ +H
Sbjct: 1664 ALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQ 1723
Query: 819 MKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERW 878
+ N + + D Q + E+ +I + E+ +K D +M +++ ++
Sbjct: 1724 NTSLINTKKKLETDI-SQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQ----- 1777
Query: 879 LQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGR 938
+ L + + L++ ++ + L E Q+ + K + QKLE + ++ G
Sbjct: 1778 -DTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELE-------GE 1829
Query: 939 QKGYEEEIIHFKKELREPQFRDAEEKYR---EMMIVMRTTELVNK 980
+ ++ + K LR+ + + E Y+ + ++R +LV+K
Sbjct: 1830 VESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDK 1874
Score = 132 bits (333), Expect = 1e-30
Identities = 204/1073 (19%), Positives = 460/1073 (42%), Gaps = 196/1073 (18%)
Query: 51 ETLRQVRQTQGQKVK-EYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENEL 109
++L + Q +K + Q+E K +K+ E+A E ++I A+LT+ K + E+E
Sbjct: 900 DSLADAEERCDQLIKTKIQLEAK-IKEVTERA-EDEEEIN---AELTAKK---RKLEDEC 951
Query: 110 DPLKNRLKEIEHNLSKIMK----LDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQL 165
LK + ++E L+K+ K +N++K L +++ ++L ++ + + + + L
Sbjct: 952 SELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTL 1011
Query: 166 NDLYHNHQRTVR------EKERKLVDCHRELEKLNKESRLLNQEKSEL-----LVEQGRL 214
+DL + + E+++ D LE+ K L + K +L L ++ +
Sbjct: 1012 DDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTM 1071
Query: 215 QLQADRHQ--EHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEG-EAKT 271
++ D+ Q E ++ ++ + L +++E D G +++IK + E +E EA+
Sbjct: 1072 DIENDKQQLDEKLKKKEFEMSGLQSKIE-DEQALGMQLQKKIKELQARIEELEEEIEAER 1130
Query: 272 ANQLMNDFAEKETLK-QKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQL-- 328
A++ AEK+ ++++EI ++ G + E+ K++ E + ++ +L++
Sbjct: 1131 ASRAK---AEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATL 1187
Query: 329 ----------EGSSDRILELDQEL-----IKAERELSKAEKNSNVETLKMEVISLQNEKA 373
+ +D + EL +++ +K + E K+E ++ L + ++ K
Sbjct: 1188 QHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKG 1247
Query: 374 DLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIK---SRHSDELTSLLGY 430
+L++ R L+ ++ ++ T + + L D + +++ SR DE +L+
Sbjct: 1248 NLEKMCRALEDQLSEIK---TKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQ 1304
Query: 431 FPN------------KKQLEDWLHSKSK---EINQTRDRLAKLNKELASSEQNKNHINNE 475
K+QLE+ + +KS + +R L ++ ++ K +
Sbjct: 1305 LSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRA 1364
Query: 476 LKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLT 535
+ + +++ + K +E+D + EE+E++ K+ A Q +
Sbjct: 1365 MSKANSEVAQWRTK---------YETDAIQRTEELEEAKKKLA----------QRLQDAE 1405
Query: 536 DENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVP 595
+ ++ C + +T+ LQ + DL + ++ + + L KK++ D++L
Sbjct: 1406 EHVEAVNAKCASLEKTKQRLQNEVEDLMIDV----ERTNAACAALDKKQRNFDKILAEWK 1461
Query: 596 MRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVT- 654
+ + E+ + + ++++ ++ ++KN EE L T+ E ++ + ++D+T
Sbjct: 1462 QK---CEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTE 1518
Query: 655 -IMERFQM--ELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNR 711
I E + EL+ +++++ Q+ ++LQ + ++E + + +L+ K E++R
Sbjct: 1519 QIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDR 1578
Query: 712 KLIQDQQEQ----------IQHLKSTTN-ELKSEKLQISTNLQRRQQLEEQTVELS---- 756
K+ + +E ++ ++ST + E++S I + L E ++L+
Sbjct: 1579 KIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANR 1638
Query: 757 --------------------TEVQSLYREIKDAKEQVSPLETTLEKFQQEKEEL---INK 793
+ R +D KEQ++ +E Q E EEL + +
Sbjct: 1639 MAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQ 1698
Query: 794 KNTSNKIAQDKLNDIKEKVKNIHGY------------------MKDIENYIQDGKDDYKK 835
S KIA+ +L D E+V+ +H ++E+ IQ+ ++ +K
Sbjct: 1699 TERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEK 1758
Query: 836 QKET---------ELNKVIAQLSECEKHKEKINEDMRLMRQDIDT-------------QK 873
K+ EL K + E+ K+ + + ++ ++ +D QK
Sbjct: 1759 AKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQK 1818
Query: 874 I--------------QERWLQDNLTLRKRNEELKEV----EEERKQHLKEMGQMQVLQMK 915
+ Q+R ++ LRK ++KE+ EE+RK L+ + LQ K
Sbjct: 1819 LEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAK 1878
Query: 916 SEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKYREM 968
+ K + + N NL+ R+ +E E + ++ E Q K RE+
Sbjct: 1879 VKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADIAESQVNKLRVKSREV 1931
Score = 130 bits (327), Expect = 7e-30
Identities = 189/861 (21%), Positives = 362/861 (42%), Gaps = 122/861 (14%)
Query: 231 LIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQI 290
L++S T+ E+ + E+ + K +R+E E K LM + + + Q +
Sbjct: 843 LLKSAETEKEMANMKEE--FEKTKEELAKTEAKRKELEEKMVT-LMQEKNDLQLQVQAEA 899
Query: 291 DEIRDKKTGLGRIIELKSEILSK------KQNELKNVKYELQQLEGS-SDRILELDQELI 343
D + D + ++I+ K ++ +K + + + + EL + D EL +++
Sbjct: 900 DSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDID 959
Query: 344 KAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNH-HTTTRTQMEML 402
E L+K EK + K++ +L E A LD T+ KL +E + L H T ++
Sbjct: 960 DLELTLAKVEKEKHATENKVK--NLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQA- 1016
Query: 403 TKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKEL 462
+ DK + K K + ++ L G +K++ L +++ L +
Sbjct: 1017 ---EEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGD---LKLAQEST 1070
Query: 463 ASSEQNKNHINNELKRKEEQLSSYEDKLFD--VCGSQ------DFESDLDRLKEEIE--- 511
E +K ++ +LK+KE ++S + K+ D G Q + ++ ++ L+EEIE
Sbjct: 1071 MDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAER 1130
Query: 512 ----KSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLR 567
K+ KQR+ L+ S+ +L + + + + EAE Q++ DL+
Sbjct: 1131 ASRAKAEKQRSDLSRELEEISE---RLEEAGGATSAQIEMNKKREAEFQKMRRDLEE--- 1184
Query: 568 LAPDKLKSTESELKKKEKRRDEMLG-----LVPMRQSIIDLKEK---EIPELRNKLQNVN 619
A + ++T + L+KK LG L ++Q + K + EI +L + ++ V+
Sbjct: 1185 -ATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVS 1243
Query: 620 RDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIME-RFQMELKDVERKI-------- 670
+ L+ E L I +EE + + D+T R Q E + R++
Sbjct: 1244 KAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVS 1303
Query: 671 ----AQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKS 726
+QA Q +L R +++ + K H L + +L R+ +++QE L+
Sbjct: 1304 QLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQR 1363
Query: 727 TTNELKSEKLQISTN-----LQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLE 781
++ SE Q T +QR ++LEE +L+ +Q ++ + + LE T +
Sbjct: 1364 AMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQ 1423
Query: 782 KFQQEKEELINKKNTSNK--IAQDK--------LNDIKEKVKNIHGYMKDIENYIQDGKD 831
+ Q E E+L+ +N A DK L + K+K + H + +
Sbjct: 1424 RLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAEL--------EASQ 1475
Query: 832 DYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDI---------------DTQKIQE 876
+ TEL K+ E E + + + ++Q+I + +KI++
Sbjct: 1476 KESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKK 1535
Query: 877 RWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQK----LEENIDNIKRNH 932
+ Q+ L+ EE + E + + + Q+++ Q+KSE + +E ID +KRNH
Sbjct: 1536 QVEQEKSELQAALEEAEASLEHEEGKILRI-QLELNQVKSEVDRKIAEKDEEIDQMKRNH 1594
Query: 933 -NLALGRQKGYEEEI------IHFKKELR------EPQFRDAEEKYREMMIVMRTTELVN 979
+ Q + EI I KK++ E Q A E + R T+ +
Sbjct: 1595 IRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAIL 1654
Query: 980 KDLDIYYKTLDQAIMKFHSMK 1000
KD ++ LD A+ +K
Sbjct: 1655 KDTQLH---LDDALRSQEDLK 1672
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 134 bits (336), Expect = 7e-31
Identities = 211/1059 (19%), Positives = 433/1059 (40%), Gaps = 145/1059 (13%)
Query: 51 ETLRQVRQTQGQKVK-EYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENEL 109
+ L + Q +K + Q+E K +K+ E+A E ++I A+LT+ K + E+E
Sbjct: 900 DALADAEERCDQLIKTKIQLEAK-IKEVTERA-EDEEEIN---AELTAKK---RKLEDEC 951
Query: 110 DPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLY 169
LK + ++E L+K+ K E A +++ K + ++ + L+E + K+ ++ L
Sbjct: 952 SELKKDIDDLELTLAKVEK---EKHATENKVKNLTEEMAGLDETIAKL----TKEKKALQ 1004
Query: 170 HNHQRTVREKERKLVDCHRELEKLN---KESRLLNQEKSEL---LVEQGRLQLQADRHQE 223
HQ+T L D E +K+N K L Q+ +L L ++ +L + +R +
Sbjct: 1005 EAHQQT-------LDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKR 1057
Query: 224 HIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKL--VRERQEGEAKTANQLMNDFAE 281
+ L Q E D + +E+ K ++ ++ + E E A QL E
Sbjct: 1058 KLEGDLKLAQESTMDTEND---KQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKE 1114
Query: 282 KETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQE 341
+ ++ +EI ++ + + +S++ EL+ + L++ G++ +E+++
Sbjct: 1115 LQARIEELEEEIEAERASRAKAEKQRSDL----SRELEEISERLEEAGGATSAQIEMNK- 1169
Query: 342 LIKAERELSKAEKNSNVETLKME--VISLQNEKAD-----------LDRTLRKLDQEMEQ 388
K E E K ++ TL+ E +L+ + AD L R +KL++E +
Sbjct: 1170 --KREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSE 1227
Query: 389 LNHH-TTTRTQMEMLTKDKAD-------KDEQIRKIKSRHSDELTSLLGYFPNKKQLEDW 440
L + ME ++K KA+ ++Q+ +IK++ ++ + K +
Sbjct: 1228 LKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKAR---- 1283
Query: 441 LHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFE 500
LH++S E ++ D + +L+ +Q ELKR+ E+ + + L Q
Sbjct: 1284 LHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHAL--QSAR 1341
Query: 501 SDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVIS 560
D D L+E+ E+ + +A L + + + Q + ++ Q EL+E
Sbjct: 1342 HDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYET------DAIQRTEELEEAKK 1395
Query: 561 DLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNR 620
L +L+ A + +++ S+ EK + + V ++ L K +N ++
Sbjct: 1396 KLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDK 1455
Query: 621 DIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIM---------------ERFQMELKD 665
+ K EE + L E S L V + Q E+ D
Sbjct: 1456 VLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISD 1515
Query: 666 VERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLK 725
+ +IA+ + +L++ +Q++ EK E Q L+ + +E I Q ++ +K
Sbjct: 1516 LTEQIAEGGKHIH--ELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVK 1573
Query: 726 STTNELKSEKLQISTNLQRR--QQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKF 783
S + +EK + L+R + +E L E++S ++ K K
Sbjct: 1574 SEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKK-----------KM 1622
Query: 784 QQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQD---GKDDYKKQKETE 840
+ + E+ + N +N+ A + L ++ +N G +KD + ++ D G+DD K+
Sbjct: 1623 EGDLNEMEIQLNHANRQAAEALRNL----RNTQGILKDTQLHLDDAIRGQDDLKE----- 1673
Query: 841 LNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERK 900
QL+ E+ + ++ +R ++ + + + L +L +
Sbjct: 1674 ------QLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSL 1727
Query: 901 QHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRD 960
+ K+ + + Q++ E + + + N + A+ EE+ KKE +
Sbjct: 1728 INTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEEL---KKEQDTSAHLE 1784
Query: 961 AEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQD 1020
+K E + KDL + +Q +K +++++ +R+L
Sbjct: 1785 RMKKNMEQTV---------KDLQLRLDEAEQLALKGGKKQIQKLEARVREL--------- 1826
Query: 1021 IEYIEIRSDADENVSASDKRRNYNYRVVMLKGDTALDMR 1059
E+ S+ NV A R + RV L T D +
Sbjct: 1827 --ESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRK 1863
Score = 107 bits (266), Expect = 9e-23
Identities = 159/808 (19%), Positives = 316/808 (39%), Gaps = 129/808 (15%)
Query: 338 LDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRT 397
+ +E K + EL+K E + L+ ++++L EK DL Q + +
Sbjct: 856 MKEEFEKTKEELAKTEAKR--KELEEKMVTLMQEKNDLQL------QVQAEADALADAEE 907
Query: 398 QMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAK 457
+ + L K K + +I+++ R DE K++LED K+I+ LAK
Sbjct: 908 RCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 967
Query: 458 LNKELASSEQNKNHINNELKRKEEQLS--SYEDKLFDVCGSQDFESDLDRLKEEIEKSSK 515
+ KE ++E ++ E+ +E ++ + E K Q + DL ++++ +K
Sbjct: 968 VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLD-DLQMEEDKVNTLTK 1026
Query: 516 QRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKS 575
+ L Q + L + +C +L+ L+ L+LA +
Sbjct: 1027 AKTKL-------EQQVDDLEGSLEQEKKLCM-------DLERAKRKLEGDLKLAQESTMD 1072
Query: 576 TESE-------LKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQ---RL 625
TE++ LKKKE + G + Q++ +K+I EL+ +++ + +I+
Sbjct: 1073 TENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERAS 1132
Query: 626 KNDIEEQETLLGTIMPE-----EESAKVCLTDVTIMER----FQMELKDVERKIAQQAAK 676
+ E+Q + L + E EE+ + + ++ FQ +D+E Q A
Sbjct: 1133 RAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEAT 1192
Query: 677 LQGI----------------DLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQ 720
+ L R Q++ +EK E + +++ ++S +E K + ++
Sbjct: 1193 AAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKM 1252
Query: 721 IQHLKSTTNELKSEKLQISTNLQRR--QQLEEQTVELSTEVQSLYREIKDAKEQVSPLET 778
+ L+ +E+K+++ + Q+R +L Q L TE R++ + VS L
Sbjct: 1253 CRTLEDQLSEIKTKEEE-----QQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSR 1307
Query: 779 TLEKFQQEKEELINKKNTSNK-----------------IAQDKLNDIKEKVKNIHGYMKD 821
+ F Q+ EEL + K + +++ + +E + M
Sbjct: 1308 GKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSK 1367
Query: 822 IENYIQDGKDDYK-------KQKETELNKVIAQLSECEKHKEKINE--------DMRLMR 866
+ + + Y+ ++ E K+ +L + E+H E +N RL
Sbjct: 1368 ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQN 1427
Query: 867 QDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENID 926
+ D ER + L K+ +V E KQ +E Q ++ + E + L +
Sbjct: 1428 EVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEET-QAELEASQKESRSLSTELF 1486
Query: 927 NIKRNHNLALGRQKGYEEEIIHFKKELRE-----PQFRDAEEKYREMMIVMRTTELVNKD 981
+K YEE + H + RE + D E+ E + E V K
Sbjct: 1487 KVK----------NAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQ 1536
Query: 982 LDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQDIEYIEIRSDADENVSASDK-- 1039
LD L ++ + + E KI+R +E +++S+ D ++ D+
Sbjct: 1537 LDHEKSELQTSLEEAEASLEHEEGKILR---------IQLELNQVKSEIDRKIAEKDEEL 1587
Query: 1040 ---RRNYNYRVVMLKGDTALDMRGRCSA 1064
+RN+ V ++ ++R R A
Sbjct: 1588 DQLKRNHLRVVESMQSTLDAEIRSRNDA 1615
Score = 106 bits (264), Expect = 1e-22
Identities = 169/871 (19%), Positives = 369/871 (42%), Gaps = 167/871 (19%)
Query: 49 ALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQL----------TSS 98
A++ +++++ Q +++E + E++ + + KA + R ++ + ++ TS+
Sbjct: 1105 AIQLQKKIKELQA-RIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSA 1163
Query: 99 K-EIVKSYENELDPLKNRLKE--IEHNLS----------KIMKLDNEIKALDSRKKQMEK 145
+ E+ K E E ++ L+E ++H + + +L +I +L K+++EK
Sbjct: 1164 QIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEK 1223
Query: 146 DNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKE------RKLVDCHRELE-KLNKESR 198
+ SEL KME +NDL N + + K R L D E++ K ++ R
Sbjct: 1224 EKSEL--KME---------INDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQR 1272
Query: 199 LLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFS-ERQIKNF 257
L+N EL ++ RL ++ + +D+++ L+ RG + +QI+
Sbjct: 1273 LIN----ELSAQKARLHTESGEFSRQLDEKDAMVSQLS---------RGKQAFTQQIEEL 1319
Query: 258 HKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGR-IIELKSEILS---- 312
+ + E + ++ A+ L + + + L++ Q +E ++ K L R + + SE+
Sbjct: 1320 KRQLEEETKAKSTLAHALQSARHDCDLLRE-QYEEEQEAKAELQRGMSKANSEVAQWRTK 1378
Query: 313 ------KKQNELKNVKYEL-QQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEV 365
++ EL+ K +L Q+L+ + + + ++ + E+ +K + VE L ++V
Sbjct: 1379 YETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEK--TKQRLQNEVEDLMIDV 1436
Query: 366 -------ISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKS 418
I+L ++ + D+ L + Q+ E+ T+ ++E K+ ++ K+K+
Sbjct: 1437 ERSNAACIALDKKQRNFDKVLAEWKQKYEE------TQAELEASQKESRSLSTELFKVKN 1490
Query: 419 RHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKR 478
+ + L L K L+ + +++I + + +L K + K+ + L+
Sbjct: 1491 AYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEE 1550
Query: 479 KEEQLSSYEDKLFDVCGSQDFESDLDRLKEEI-----EKSSKQRAMLAGATAVYSQFITQ 533
E L E K+ + + +L+++K EI EK + + V +
Sbjct: 1551 AEASLEHEEGKILRI------QLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQST 1604
Query: 534 LTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKL----------KSTESELKKK 583
L E +S + + E +L E+ L R A + L K T+ L
Sbjct: 1605 LDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDA 1664
Query: 584 EKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQ-------------------- 623
+ +D++ + M + +L + E+ ELR L+ R +
Sbjct: 1665 IRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQN 1724
Query: 624 --------RLKNDIEEQETLLGTIMPE----EESAKVCLTDVTIM--------------- 656
+L+ DI + + + I+ E EE AK +TD +M
Sbjct: 1725 TSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1784
Query: 657 ---ERFQMELKDVE------RKIAQQAAKLQGIDLDRTVQQVNQE-KQEKQHKLDTVSSK 706
+ + +KD++ ++A + K Q L+ V+++ E + E++H ++ V
Sbjct: 1785 RMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKG- 1843
Query: 707 IELNRKLIQDQQEQIQHLKSTTNELKS--EKLQISTNLQRRQ--QLEEQTVELSTEVQSL 762
+ + + +++ Q + + L+ +KLQ +RQ + EEQ+ + + L
Sbjct: 1844 LRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKL 1903
Query: 763 YREIKDAKEQVSPLETTLEKFQQEKEELINK 793
E+++AKE+ E+ + K + + E+ K
Sbjct: 1904 QHELEEAKERADIAESQVNKLRVKSREVHTK 1934
Score = 85.5 bits (210), Expect = 3e-16
Identities = 134/744 (18%), Positives = 312/744 (41%), Gaps = 88/744 (11%)
Query: 456 AKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQD-----FESDLDRLKEEI 510
A+ KE+A+ ++ EL + E + E+K+ + ++ +++ D L +
Sbjct: 847 AETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAE 906
Query: 511 EKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTE---AELQEVISDLQSKLR 567
E+ + A + + DE + + + + E +EL++ I DL+ L
Sbjct: 907 ERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLA 966
Query: 568 LAPDKLKSTESELKKKEKRR---DEMLG-LVPMRQSIIDLKEKEIPELRNKLQNVNRDIQ 623
+ +TE+++K + DE + L ++++ + ++ + +L+ + VN +
Sbjct: 967 KVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNT-LT 1025
Query: 624 RLKNDIEEQ-ETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDL 682
+ K +E+Q + L G++ E+ K+C+ +ER + +L+ + K+AQ++ +D
Sbjct: 1026 KAKTKLEQQVDDLEGSL---EQEKKLCMD----LERAKRKLEG-DLKLAQEST----MDT 1073
Query: 683 DRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNL 742
+ QQ+N++ ++K+ ++ + KIE + L Q++I+ L++ EL+ E I
Sbjct: 1074 ENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEE---IEAER 1130
Query: 743 QRRQQLEEQTVELSTEVQSLYREIKDAK-------EQVSPLETTLEKFQQEKEE-LINKK 794
R + E+Q +LS E++ + +++A E E +K +++ EE + +
Sbjct: 1131 ASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHE 1190
Query: 795 NTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKH 854
T+ + + + + E + I + ++ + K + + E+N + + + K
Sbjct: 1191 ATAAALRKKHADSVAELGEQIDSLQR-----VKQKLEKEKSELKMEINDLASNMETVSKA 1245
Query: 855 KEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQM 914
K + R TL + E+K EEE+++ + E+ Q ++
Sbjct: 1246 KANFEKMCR--------------------TLEDQLSEIKTKEEEQQRLINEL-SAQKARL 1284
Query: 915 KSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKYREMMIVMRT 974
+E + +D + ++ + ++I K++L EE+ + +
Sbjct: 1285 HTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQL--------EEETKAKSTLAHA 1336
Query: 975 TELVNKDLDIYYKTLDQAIMKFHSMK--MEEINKIIRDLWRSTYRGQDIEYIEIRSDADE 1032
+ D D+ + ++ ++ M + N + WR+ Y I+ E +A +
Sbjct: 1337 LQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQ-WRTKYETDAIQRTEELEEAKK 1395
Query: 1033 NVSASDKRRNYNYRVVMLKGDTALDMRGRCSAGQKVLASLIIRLALAETFCLNCGIIALD 1092
++ + + V K + + R Q + L+I + + C IALD
Sbjct: 1396 KLAQRLQDAEEHVEAVNSKCASLEKTKQRL---QNEVEDLMIDVERSNAAC-----IALD 1447
Query: 1093 EPTTNLDR---ENIESLAHALVEIIKSRSQQRNFQLLVITHDEDFVELLGRSEYVEKFYR 1149
+ N D+ E + E+ S+ + R+ + + E L +++E R
Sbjct: 1448 KKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESL---DHLETLKR 1504
Query: 1150 IKKNIDQCSEIVKCSVSSLGFNVH 1173
KN+ Q + ++ G ++H
Sbjct: 1505 ENKNLQQEISDLTEQIAEGGKHIH 1528
Score = 40.0 bits (92), Expect = 0.013
Identities = 40/203 (19%), Positives = 92/203 (45%), Gaps = 32/203 (15%)
Query: 751 QTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQ---DKLND 807
++ E E+ ++ E + KE+++ E ++ +++ L+ +KN Q D L D
Sbjct: 845 KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALAD 904
Query: 808 IKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQ 867
+E+ + +E I++ + + + E E+N +E K K+ ++ +++
Sbjct: 905 AEERCDQLIKTKIQLEAKIKEVTE--RAEDEEEIN------AELTAKKRKLEDECSELKK 956
Query: 868 DIDTQKI------QERWLQDNL-------------TLRKRNEELKEVEEERKQHLK--EM 906
DID ++ +E+ +N T+ K +E K ++E +Q L +M
Sbjct: 957 DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQM 1016
Query: 907 GQMQVLQMKSEHQKLEENIDNIK 929
+ +V + KLE+ +D+++
Sbjct: 1017 EEDKVNTLTKAKTKLEQQVDDLE 1039
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 133 bits (334), Expect = 1e-30
Identities = 202/1008 (20%), Positives = 417/1008 (41%), Gaps = 154/1008 (15%)
Query: 76 QYKEKACEIRDQITSKE---AQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNE 132
Q + K E+ +++ +E A+LT+ K + E+E LK + ++E L+K+ K E
Sbjct: 914 QLEAKVKEMNERLEDEEEMNAELTAKK---RKLEDECSELKRDIDDLELTLAKVEK---E 967
Query: 133 IKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEK 192
A +++ K + ++ + L+E + K+ ++ L HQ+ L D E +K
Sbjct: 968 KHATENKVKNLTEEMAGLDEIIAKL----TKEKKALQEAHQQA-------LDDLQAEEDK 1016
Query: 193 LN---KESRLLNQEKSEL---LVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFER 246
+N K L Q+ +L L ++ ++++ +R + + L Q LE D +
Sbjct: 1017 VNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLEND---K 1073
Query: 247 GPFSERQIKNFHKL--VRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRII 304
ER K +L + R E E +QL E + ++ +E+ ++T ++
Sbjct: 1074 QQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVE 1133
Query: 305 ELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKME 364
+L+S++ EL+ + L++ G++ +E+++ K E E K ++ TL+ E
Sbjct: 1134 KLRSDL----SRELEEISERLEEAGGATSVQIEMNK---KREAEFQKMRRDLEEATLQHE 1186
Query: 365 --VISLQNEKAD-----------LDRTLRKLDQEMEQLNHHTTTRT-QMEMLTKDKADKD 410
+L+ + AD L R +KL++E + T ME + K KA+ +
Sbjct: 1187 ATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLE 1246
Query: 411 EQIRKIK---SRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQ 467
+ R ++ + H + + L +++ E+++ D L +L +
Sbjct: 1247 KMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKL 1306
Query: 468 NKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDL--DRLKEEIEKSSKQRAMLAGATA 525
+LKR+ E+ ++ L S + DL ++ +EE E ++ + +L+ A +
Sbjct: 1307 TYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANS 1366
Query: 526 VYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEK 585
+Q+ T+ + Q EL+E L +L+ A + +++ ++ EK
Sbjct: 1367 EVAQWRTKYETD----------AIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEK 1416
Query: 586 RRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEES 645
+ + + ++ L K +N ++ + K EE ++ L + E S
Sbjct: 1417 TKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARS 1476
Query: 646 AKVCL--------TDVTIMERFQMELKDVERKIAQQAAKLQGI-----DLDRTVQQVNQE 692
L + +E F+ E K+++ +I+ +L +L++ +Q+ E
Sbjct: 1477 LSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAE 1536
Query: 693 KQEKQHKLDTVSS-------------------KIELNRKLIQDQQEQIQ----HLK---- 725
K E Q L+ + K E+ RKL + +E Q HL+
Sbjct: 1537 KMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDS 1596
Query: 726 ---STTNELKSEKLQISTNLQRRQQLEEQTVELS----------TEVQSLYREIKDA--- 769
S E +S + + L E ++LS +V+SL +KD
Sbjct: 1597 LQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQ 1656
Query: 770 -----------KEQVSPLETTLEKFQQEKEEL---INKKNTSNKIAQDKLNDIKEKVKNI 815
KE ++ +E Q E EEL + + S K+A+ +L + E+V+ +
Sbjct: 1657 LDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLL 1716
Query: 816 HGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQ 875
H + N + D Q +TE+ + + + E+ +K D +M +++ ++
Sbjct: 1717 HSQNTSLINQ-KKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQ-- 1773
Query: 876 ERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLA 935
+ L + + +++ ++ + L E Q+ + K + QKLE + ++ N
Sbjct: 1774 ----DTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELE---NEL 1826
Query: 936 LGRQKGYEEEIIHFKKELREPQFRDAEEKYR---EMMIVMRTTELVNK 980
QK E + K +R+ + R E Y+ + ++R +LV+K
Sbjct: 1827 EAEQKRNAESV----KGMRKSERRIKELTYQTEEDRKNLLRLQDLVDK 1870
Score = 113 bits (283), Expect = 9e-25
Identities = 188/899 (20%), Positives = 379/899 (42%), Gaps = 150/899 (16%)
Query: 178 EKERKLVDCHRE-------LEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIR-ARD 229
E+E+++ E LEK + L ++ LL E+ LQLQ Q+++ A +
Sbjct: 844 EREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEE 903
Query: 230 SLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQ 289
Q + +++L E ++K ++ + + +E MN AE K+K
Sbjct: 904 RCDQLIKNKIQL---------EAKVKEMNERLEDEEE---------MN--AELTAKKRKL 943
Query: 290 IDEIRDKKTGLGRIIELKSEILSKK---QNELKNVKYELQQLEGSSDRILELDQELIKAE 346
DE + K + + +++ +K +N++KN+ E+ L+ E+ +L K +
Sbjct: 944 EDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD-------EIIAKLTKEK 996
Query: 347 RELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDK 406
+ L +A + + ++ L+ E +++ L + KL+Q+++ L +E K +
Sbjct: 997 KALQEAHQQA-LDDLQAE----EDKVNTLTKAKVKLEQQVDDL------EGSLEQEKKVR 1045
Query: 407 ADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSE 466
D + RK++ S++ +K+QL++ L K E+N A++ E A
Sbjct: 1046 MDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALN---ARIEDEQALGS 1102
Query: 467 QNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAV 526
Q + + R EE E + + SDL R E+E+ S++ GAT+V
Sbjct: 1103 QLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSR---ELEEISERLEEAGGATSV 1159
Query: 527 YSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKR 586
+ + EAE Q++ DL+ A + ++T + L+KK
Sbjct: 1160 QIEMNK-----------------KREAEFQKMRRDLEE----ATLQHEATAAALRKKHAD 1198
Query: 587 RDEMLG-LVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRL---KNDIEEQETLLGTIMPE 642
LG + Q + EKE E + +L +V +++++ K ++E+ L M E
Sbjct: 1199 SVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNE 1258
Query: 643 E----ESAKVCLTDVTIME-RFQMELKDVERKIAQQAAKLQGI------------DLDRT 685
E + + D+T + Q E ++ R++ ++ A + + DL R
Sbjct: 1259 HRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQ 1318
Query: 686 VQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTN---- 741
+++ + K H L + +L R+ +++ E L+ ++ SE Q T
Sbjct: 1319 LEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETD 1378
Query: 742 -LQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKI 800
+QR ++LEE +L+ +Q ++ + S LE T + Q E E+L+ SN
Sbjct: 1379 AIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAA 1438
Query: 801 AQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYK-KQKE-----TELNKVIAQLSECEKH 854
A + +K +N + + + ++ + + + QKE TEL K+ E +H
Sbjct: 1439 AA----ALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEH 1494
Query: 855 KEKINEDMRLMRQDI---------------DTQKIQERWLQDNLTLRKRNEELK-EVEEE 898
E + + ++++I + +K++++ + + L+ EE + +E E
Sbjct: 1495 LETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHE 1554
Query: 899 RKQHLKEMGQMQVLQMKSEHQK----LEENIDNIKRNH-------NLALGRQKGYEEEII 947
+ L+ Q++ Q+K+E ++ +E ++ KRNH +L + E +
Sbjct: 1555 EGKILR--AQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEAL 1612
Query: 948 HFKKELR------EPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMK 1000
KK++ E Q A E +++ + + KD I LD A+ +K
Sbjct: 1613 RVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQI---QLDDAVRANDDLK 1668
Score = 100 bits (248), Expect = 1e-20
Identities = 173/819 (21%), Positives = 333/819 (40%), Gaps = 126/819 (15%)
Query: 323 YELQQLEGSSDRILEL---DQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTL 379
++++ L S++R E+ +E + + L K+E + L+ +++SL EK DL
Sbjct: 834 FKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARR--KELEEKMVSLLQEKNDL---- 887
Query: 380 RKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLED 439
+L + EQ N + + L K+K + +++++ R DE K++LED
Sbjct: 888 -QLQVQAEQDNL-ADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLED 945
Query: 440 WLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNEL-----------KRKEEQLSSYED 488
++I+ LAK+ KE ++E ++ E+ K K+ +++
Sbjct: 946 ECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQ 1005
Query: 489 KLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRV 548
L D+ +D + L + K ++E +Q L G+ L E + + +
Sbjct: 1006 ALDDLQAEEDKVNTLTKAKVKLE---QQVDDLEGS----------LEQEKKVRMDLERAK 1052
Query: 549 FQTEAEL---QEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKE 605
+ E +L QE I DL++ + ++LK + EL R ++ L Q + +
Sbjct: 1053 RKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQ 1112
Query: 606 KEIPELRNKLQ---NVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIME--RFQ 660
I EL +L+ +++L++D+ + + + E A ++ FQ
Sbjct: 1113 ARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQ 1172
Query: 661 MELKDVE--------------RKIAQQAAKL--QGIDLDRTVQQVNQEKQEKQHKLDTVS 704
+D+E +K A A+L Q +L R Q++ +EK E + +LD V+
Sbjct: 1173 KMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVT 1232
Query: 705 SKIELNRKLIQDQQEQIQHLKSTTNE--LKSEKLQISTNLQRRQQLEEQTVELSTEVQSL 762
S +E K + ++ + L+ NE K+E+ Q S N L Q +L TE L
Sbjct: 1233 SNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVN-----DLTSQRAKLQTENGEL 1287
Query: 763 YREIKDAKEQVSPL-------ETTLEKFQQEKEELINKKNTSNKIAQDKLND---IKEKV 812
R++ + + +S L LE +++ EE + KN Q +D ++E+
Sbjct: 1288 SRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQY 1347
Query: 813 KNIHGYMKDIENYIQDGKDD---YKKQKET----------ELNKVIAQ-LSECEKHKEKI 858
+ +++ + + ++ + ET E K +AQ L E E+ E +
Sbjct: 1348 EEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAV 1407
Query: 859 NEDM--------RLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQ 910
N RL + D ER L K+ ++ E KQ +E Q +
Sbjct: 1408 NAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEE-SQSE 1466
Query: 911 VLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIH---FKKELR--EPQFRDAEEKY 965
+ + E + L + +K YEE + H FK+E + + + D E+
Sbjct: 1467 LESSQKEARSLSTELFKLK----------NAYEESLEHLETFKRENKNLQEEISDLTEQL 1516
Query: 966 REMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQDIEYIE 1025
+ E V K L+ L A+ + + E KI+R +E+ +
Sbjct: 1517 GSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILR---------AQLEFNQ 1567
Query: 1026 IRSDADENVSASD---KRRNYNYRVVMLKGDTALDMRGR 1061
I+++ + ++ D ++ N+ V+ T+LD R
Sbjct: 1568 IKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETR 1606
Score = 66.2 bits (160), Expect = 2e-10
Identities = 126/571 (22%), Positives = 244/571 (42%), Gaps = 114/571 (19%)
Query: 72 KYLKQYKEKACEIRDQITSKEAQLTS-SKEIVK---SYENELDPLKNRLKEIEHNLSKIM 127
K L ++K+K E + ++ S + + S S E+ K +YE L+ L+ +E ++ +I
Sbjct: 1451 KILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEIS 1510
Query: 128 KLDNEIKALDSRKKQMEKDNSELE-EKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDC 186
L ++ + ++EK +LE EKME L + ++ +E K++
Sbjct: 1511 DLTEQLGSSGKTIHELEKVRKQLEAEKME---------LQSALEEAEASLEHEEGKILRA 1561
Query: 187 HRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQ-------L 239
E ++ E EK E + EQ + + H+R DSL SL + L
Sbjct: 1562 QLEFNQIKAEIERKLAEKDEEM-EQAK--------RNHLRVVDSLQTSLDAETRSRNEAL 1612
Query: 240 ELDGFERGPFSERQIKNFH--KLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKK 297
+ G +E +I+ H ++ E Q+ + K+ L+ D + + D++++
Sbjct: 1613 RVKKKMEGDLNEMEIQLSHANRMAAEAQK-QVKSLQSLLKDTQIQLDDAVRANDDLKENI 1671
Query: 298 TGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSN 357
I+E ++ +L Q EL+ ++ ++Q E S +QELI E +
Sbjct: 1672 A----IVERRNNLL---QAELEELRAVVEQTERSRKL---AEQELI---------ETSER 1712
Query: 358 VETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIK 417
V+ L + SL N+K +K+D ++ QL +T++E ++ + +E+
Sbjct: 1713 VQLLHSQNTSLINQK-------KKMDADLSQL------QTEVEEAVQECRNAEEKA---- 1755
Query: 418 SRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELK 477
KK + D ++E+ + +D A L + + EQ + + L
Sbjct: 1756 ----------------KKAITD-AAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLD 1798
Query: 478 RKEE-QLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTD 536
E+ L + +L Q E+ + L+ E+E K+ A + I +LT
Sbjct: 1799 EAEQIALKGGKKQL------QKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELT- 1851
Query: 537 ENQSCCPVCQRVFQTEAELQEV--ISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLV 594
+QTE + + + + DL KL+L K+K+ + + ++ E++ + L
Sbjct: 1852 ------------YQTEEDRKNLLRLQDLVDKLQL---KVKAYKRQAEEAEEQANTNLSKF 1896
Query: 595 PMRQSIIDLKEK--EIPELR-NKLQNVNRDI 622
Q +D E+ +I E + NKL+ +RDI
Sbjct: 1897 RKVQHELDEAEERADIAESQVNKLRAKSRDI 1927
Score = 57.4 bits (137), Expect = 8e-08
Identities = 71/386 (18%), Positives = 167/386 (43%), Gaps = 54/386 (13%)
Query: 51 ETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQ----ITSKEAQLTSSKEIVKSYE 106
E + Q ++ + V Q L + + +A ++ + + E QL+ + + +
Sbjct: 1581 EEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQ 1640
Query: 107 NELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLN 166
++ L++ LK+ + ++LD+ ++A D K +N + E+ + Q E+L
Sbjct: 1641 KQVKSLQSLLKDTQ------IQLDDAVRANDDLK-----ENIAIVERRNNLLQAELEELR 1689
Query: 167 DLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIR 226
+ +R+ + E++L++ ++ L+ ++ L +K ++ + +LQ + + + R
Sbjct: 1690 AVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECR 1749
Query: 227 ARDSLIQSLATQLELDGFE------RGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFA 280
+ + T + E ER KN + +++ Q D A
Sbjct: 1750 NAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQH---------RLDEA 1800
Query: 281 EKETLK--QKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILEL 338
E+ LK +KQ+ ++ R+ EL++E+ ++++ ++VK + S RI EL
Sbjct: 1801 EQIALKGGKKQLQKLE------ARVRELENELEAEQKRNAESVK----GMRKSERRIKEL 1850
Query: 339 DQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQ 398
+ + + L + + + LK++ Q E+A +E N + Q
Sbjct: 1851 TYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEA----------EEQANTNLSKFRKVQ 1900
Query: 399 MEM-LTKDKAD-KDEQIRKIKSRHSD 422
E+ +++AD + Q+ K++++ D
Sbjct: 1901 HELDEAEERADIAESQVNKLRAKSRD 1926
Score = 45.4 bits (106), Expect = 3e-04
Identities = 67/353 (18%), Positives = 154/353 (43%), Gaps = 44/353 (12%)
Query: 706 KIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTV-------ELSTE 758
K+ K + E+ + + S E K + + RR++LEE+ V +L +
Sbjct: 831 KLYFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQ 890
Query: 759 VQSLYREIKDAKEQVS-------PLETTLEKFQQ--EKEELINKKNTSNK-IAQDKLNDI 808
VQ+ + DA+E+ LE +++ + E EE +N + T+ K +D+ +++
Sbjct: 891 VQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSEL 950
Query: 809 KEKVKNIHGYMKDI--ENYIQDGKDDYKKQKETELNKVIAQLSECEK-----HKEKINED 861
K + ++ + + E + + K ++ L+++IA+L++ +K H++ + +D
Sbjct: 951 KRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQAL-DD 1009
Query: 862 MRLMRQDIDT---QKIQERWLQDNLTLRKRNEELKEVEEERKQHLKE----MGQMQVLQM 914
++ ++T K++ D+L E+ ++ ER + E + Q ++ +
Sbjct: 1010 LQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDL 1069
Query: 915 KSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFR--DAEEKYREMMIVM 972
+++ Q+L+E + N R + + +K+L+E Q R + EE+
Sbjct: 1070 ENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTAR 1129
Query: 973 RTTELVNKDLDIYYKTLDQAI----------MKFHSMKMEEINKIIRDLWRST 1015
E + DL + + + + ++ + + E K+ RDL +T
Sbjct: 1130 AKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEAT 1182
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 132 bits (332), Expect = 2e-30
Identities = 202/1055 (19%), Positives = 452/1055 (42%), Gaps = 182/1055 (17%)
Query: 42 SATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSK---------- 91
+A + +ETL+ Q +K+ + Q +L+ + +A E+R ++T+K
Sbjct: 863 AAENRLTEMETLQS--QLMAEKL-QLQEQLQAETELCAEAEELRARLTAKKQELEEICHD 919
Query: 92 -EAQLTSSKEIVKSYENELDPLKNRLKEIEHNL------------------SKIMKLDNE 132
EA++ +E + + E ++ ++E+E L +K+ KL+ E
Sbjct: 920 LEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEE 979
Query: 133 IKALDSRKKQMEKDNSELEEKMEKVFQGTDEQ------LNDLYHNHQRTVREKERKLVDC 186
L+ + ++ K+ LE+++ + E+ L L + H+ + + E +L
Sbjct: 980 QIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRRE 1039
Query: 187 HRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFER 246
++ ++L K R L + ++L + LQ Q + + ++ +Q+ ++E + ++
Sbjct: 1040 EKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQK 1099
Query: 247 GPFSERQIKNFHKLVRERQEG-EAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIE 305
+ ++I+ + E QE E++ A++ + AEK+ K+ +E+ KT L ++
Sbjct: 1100 N-MALKKIRELESQISELQEDLESERASR---NKAEKQ--KRDLGEELEALKTELEDTLD 1153
Query: 306 ---LKSEILSKKQNELKNVKYELQQLEGSSD-RILELDQELIKAERELSKA-EKNSNVET 360
+ E+ SK++ E+ +K L++ + + +I E+ Q+ +A EL++ E+ V+
Sbjct: 1154 STAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKA 1213
Query: 361 -LKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSR 419
L+ +L+NE+ +L ++ L Q H R ++E ++ K + ++++
Sbjct: 1214 NLEKAKQTLENERGELANEVKVLLQGKGDSEHK---RKKVEAQLQELQVKFNEGERVRTE 1270
Query: 420 HSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRK 479
+D++T L Q+E L + + ++Q+ + +KL K+ ++ E L+ +
Sbjct: 1271 LADKVTKL--------QVE--LDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEE 1320
Query: 480 EEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQ 539
Q S KL V + S ++L+EE E +A A + ++ D +
Sbjct: 1321 NRQKLSLSTKLKQV--EDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMED-SV 1377
Query: 540 SCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQS 599
C + V + + E +S + A DKL+ T++ L+ ++ D ++ L RQS
Sbjct: 1378 GCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQ--QELDDLLVDLDHQRQS 1435
Query: 600 IIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERF 659
+L++K+ ++ + E++T+ E + A+ E
Sbjct: 1436 ACNLEKKQ---------------KKFDQLLAEEKTISAKYAEERDRAEA--------EAR 1472
Query: 660 QMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQE 719
+ E K + A + A Q +L+R +Q E ++ D V + K + ++
Sbjct: 1473 EKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQ 1532
Query: 720 QIQHLKSTTNELKSE-------KLQISTNLQ------------RRQQLEEQTVELSTEVQ 760
Q++ +K+ EL+ E KL++ NLQ R +Q EE+ +L +V+
Sbjct: 1533 QVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVR 1592
Query: 761 SLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMK 820
+ E++D ++Q S +K + + ++L +++NK + + +++ + M+
Sbjct: 1593 EMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMR 1652
Query: 821 DI-------ENYIQDGKDDYKKQK--ETELNKVIAQLSECEKHKEKINEDMRLMRQDI-- 869
++ E + K++ KK K E E+ ++ +L+ E+ K + ++ + +I
Sbjct: 1653 ELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIAN 1712
Query: 870 -------------------------------DTQKIQERWLQDNLT-------------- 884
+T+ I +R + NL
Sbjct: 1713 SSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSH 1772
Query: 885 ----------LRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNL 934
L ++N+ELK +E + +K + + ++++ +LEE +DN +
Sbjct: 1773 AQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQA 1832
Query: 935 ALGR----QKGYEEEIIHFKKELRE-PQFRDAEEK 964
A + +K ++ ++ E R Q++D +K
Sbjct: 1833 ACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADK 1867
Score = 132 bits (331), Expect = 3e-30
Identities = 199/938 (21%), Positives = 418/938 (44%), Gaps = 135/938 (14%)
Query: 91 KEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSEL 150
+E + +E+VK E +L +NRL E+E S++M +++ + Q E +
Sbjct: 844 EEEMMAKEEELVKVREKQL-AAENRLTEMETLQSQLMAEKLQLQ----EQLQAETELCAE 898
Query: 151 EEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVE 210
E++ ++L ++ H+ + V E+E + E +K+ + + L ++ E E
Sbjct: 899 AEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEE--EE 956
Query: 211 QGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQI---KNFHKLVRERQEG 267
R +LQ ++ + T+ +L E E QI KL +E++
Sbjct: 957 SARQKLQ--------------LEKVTTEAKLKKLE-----EEQIILEDQNCKLAKEKKLL 997
Query: 268 EAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQ 327
E + A N E+E K K + ++++K + +E + K++ EL+ + ++
Sbjct: 998 EDRIAEFTTNLTEEEE--KSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTR---RK 1052
Query: 328 LEGS----SDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLD 383
LEG SD+I EL ++ + + +L+K E E L+ + ++ E A + L+K+
Sbjct: 1053 LEGDSTDLSDQIAELQAQIAELKMQLAKKE-----EELQAALARVEEEAAQKNMALKKI- 1106
Query: 384 QEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHS 443
+E+E + E +++KA+K K +EL +L K +LED L S
Sbjct: 1107 RELESQISELQEDLESERASRNKAEKQ------KRDLGEELEAL------KTELEDTLDS 1154
Query: 444 KSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDL 503
+ + +EL S + + +N K EE+ ++E ++ ++ Q +
Sbjct: 1155 TAAQ------------QELRSKREQE--VNILKKTLEEEAKTHEAQIQEM--RQKHSQAV 1198
Query: 504 DRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQ 563
+ L E++E++ + +A L A +L +E + +++ + +LQ
Sbjct: 1199 EELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQ 1258
Query: 564 SKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQ 623
K ++ K + D + GL+ S K+ L ++LQ+ +Q
Sbjct: 1259 VKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQ 1318
Query: 624 -----------RLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQ 672
+LK +E+++ + EEE AK L + ++ D+++K+
Sbjct: 1319 EENRQKLSLSTKLK-QVEDEKNSFREQLEEEEEAKHNLEKQ--IATLHAQVADMKKKMED 1375
Query: 673 QAAKLQGID-----LDRTVQQVNQEKQEK---QHKLDTVSSKI--ELNRKLIQ-DQQEQ- 720
L+ + L + ++ ++Q +EK KL+ +++ EL+ L+ D Q Q
Sbjct: 1376 SVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQS 1435
Query: 721 ---IQHLKSTTNELKSEKLQISTN-LQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPL 776
++ + ++L +E+ IS + R + E + E T+ SL R +++A EQ + L
Sbjct: 1436 ACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAEL 1495
Query: 777 ETTLEKFQQEKEELINKKNTSNKIAQD---KLNDIKEKVKNIHGYMKDIENYIQDGKDDY 833
E ++F+ E E+L++ K+ K + ++++V+ + ++++E+ +Q +D
Sbjct: 1496 ERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQ-ATEDA 1554
Query: 834 KKQKETELNKVIAQL--------SECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTL 885
K + E L + AQ + E+ K+++ +R M +++ ++ Q +
Sbjct: 1555 KLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMA---VAA 1611
Query: 886 RKRNE-ELKEVE-------EERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALG 937
RK+ E +LK++E + R + +K++ ++Q QMK ++L++ R LA
Sbjct: 1612 RKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQA-QMKDCMRELDDT--RASREEILAQA 1668
Query: 938 RQ-----KGYEEEIIHFKKEL--REPQFRDAEEKYREM 968
++ K E E+I ++EL E R A+++ E+
Sbjct: 1669 KENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDEL 1706
Score = 116 bits (290), Expect = 1e-25
Identities = 186/902 (20%), Positives = 385/902 (42%), Gaps = 137/902 (15%)
Query: 65 KEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNR--------- 115
K+ Q K ++ + + ++ DQI +AQ+ K + E EL R
Sbjct: 1041 KQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKN 1100
Query: 116 --LKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQ 173
LK+I S+I +L ++++ + + + EK +L E++E + ++ L+ +
Sbjct: 1101 MALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQE 1160
Query: 174 -RTVREKERKLVDCHRELEKLNKESRL--LNQEKSELLVEQGRLQLQADRHQEHIRARDS 230
R+ RE+E ++ E E E+++ + Q+ S+ + E Q R + ++
Sbjct: 1161 LRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQ 1220
Query: 231 LIQS----LATQLELDGFERGPFSERQIKNFHKLVRERQ----EGEAKTANQLMNDFAEK 282
+++ LA ++++ +G SE + K ++E Q EGE ++ + A+K
Sbjct: 1221 TLENERGELANEVKVLLQGKGD-SEHKRKKVEAQLQELQVKFNEGE-----RVRTELADK 1274
Query: 283 ETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDR-ILELDQE 341
T Q ++D + TGL + KS L+K + L++ + Q+L +R L L +
Sbjct: 1275 VTKLQVELDNV----TGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTK 1330
Query: 342 LIKAERELSK-----AEKNSNVETLKMEVISLQNEKADLDRTL--------------RKL 382
L + E E + E+ L+ ++ +L + AD+ + + RKL
Sbjct: 1331 LKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKL 1390
Query: 383 DQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLH 442
+++E L+ ++K +++ K K+R EL LL +++Q L
Sbjct: 1391 QKDLEGLSQR----------HEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLE 1440
Query: 443 SKSKEINQ--------------TRDRLAKLNKE-------LASSEQNKNHINNELKRKEE 481
K K+ +Q RDR +E LA + + EL+R +
Sbjct: 1441 KKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNK 1500
Query: 482 QLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSC 541
Q + ++ D+ S+D D+ + E+EKS +RA+ + +Q + +L DE Q+
Sbjct: 1501 Q---FRTEMEDLMSSKD---DVGKSVHELEKS--KRALEQQVEEMKTQ-LEELEDELQAT 1551
Query: 542 CPVCQRV-FQTEAELQEVISDLQSKLRLAPDKLKS-----TESELKKKEKRRDEMLGLVP 595
R+ +A + DLQ + + +K K E E + +++R+ + +
Sbjct: 1552 EDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAA 1611
Query: 596 MRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTI 655
++ +DLK +L + + N++ + + + + M E + + ++
Sbjct: 1612 RKKLEMDLK-----DLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILA 1666
Query: 656 M-ERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSK----IELN 710
+ + +LK +E ++ Q +L +R +Q QE+ E ++ S K +E
Sbjct: 1667 QAKENEKKLKSMEAEMIQLQEELAA--AERAKRQAQQERDELADEIANSSGKGALALEEK 1724
Query: 711 RKL---IQDQQEQIQHLKSTT----NELKSEKLQI-----STNLQR---------RQQLE 749
R+L I +E+++ + T + LK LQI NL+R RQQLE
Sbjct: 1725 RRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLE 1784
Query: 750 EQTVELSTEVQSLYREIKDA-KEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDI 808
Q EL ++Q + +K K ++ LE + + +++ + ++ + K + +
Sbjct: 1785 RQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKL 1844
Query: 809 KEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQD 868
K+ + + ++ E Y D + T L ++ QL E E+ ++ N R ++++
Sbjct: 1845 KDVLLQVDDERRNAEQY-----KDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRE 1899
Query: 869 ID 870
++
Sbjct: 1900 LE 1901
Score = 105 bits (261), Expect = 3e-22
Identities = 150/751 (19%), Positives = 313/751 (41%), Gaps = 108/751 (14%)
Query: 55 QVRQTQGQKVKEYQMELK----YLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELD 110
+VR KV + Q+EL L Q K+ ++ ++ E+QL ++E+++ +
Sbjct: 1266 RVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKL 1325
Query: 111 PLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYH 170
L +LK++E + S ++Q+E++ E + +EK Q+ D+
Sbjct: 1326 SLSTKLKQVEDEKN-------------SFREQLEEEE-EAKHNLEKQIATLHAQVADM-- 1369
Query: 171 NHQRTVREKERKLVDCHRELE----KLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIR 226
++K V C E KL K+ L+Q E + +L+ R Q+ +
Sbjct: 1370 ------KKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQEL- 1422
Query: 227 ARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLK 286
D L+ L Q + E++ K F +L+ E + AK +AE+
Sbjct: 1423 --DDLLVDLDHQRQ-----SACNLEKKQKKFDQLLAEEKTISAK--------YAEERDRA 1467
Query: 287 QKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAE 346
+ + E K L R +E E ++ + K + E++ L S D + + EL K++
Sbjct: 1468 EAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSK 1527
Query: 347 RELSKA--EKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTK 404
R L + E + +E L+ E+ + ++ K L+ L+ + + E+ + + E +
Sbjct: 1528 RALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFER-----DLQGRDEQSEE 1582
Query: 405 DKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELAS 464
K Q+R++++ DE +KQ + ++ K +D L + S
Sbjct: 1583 KKKQLVRQVREMEAELEDE----------RKQRSMAVAARKKLEMDLKD----LEAHIDS 1628
Query: 465 SEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGAT 524
+ +N++ +L++ + Q+ +L D S+ E L + KE +K A +
Sbjct: 1629 ANKNRDEAIKQLRKLQAQMKDCMRELDDTRASR--EEILAQAKENEKKLKSMEAEMI--- 1683
Query: 525 AVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKE 584
QL +E + ++ Q EL + I++ K LA ++ + E+ + + E
Sbjct: 1684 --------QLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLE 1735
Query: 585 KRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEE 644
+ +E Q +L + + ++ +N D+ ++ ++ E + + +
Sbjct: 1736 EELEE-------EQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNK 1788
Query: 645 SAKVCLTDV--TIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDT 702
KV L ++ T+ +++ + +E KIAQ +L +R Q ++ + + KL
Sbjct: 1789 ELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKER--QAACKQVRRTEKKLKD 1846
Query: 703 VSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSL 762
V +++ R+ + ++Q + +LK ++ ++ EE+ + + L
Sbjct: 1847 VLLQVDDERRNAEQYKDQADKASTRLKQLK----------RQLEEAEEEAQRANASRRKL 1896
Query: 763 YREIKDAKEQVSPLETTLEKFQQEKEELINK 793
RE++DA E T + +E L NK
Sbjct: 1897 QRELEDATE-------TADAMNREVSSLKNK 1920
Score = 103 bits (256), Expect = 1e-21
Identities = 133/639 (20%), Positives = 273/639 (42%), Gaps = 87/639 (13%)
Query: 21 EDSNWPLSEGKALKQKFDEIFS--ATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYK 78
EDS L + +K+K + + R+ + + ++ +T+ + +E L L +
Sbjct: 1374 EDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQR 1433
Query: 79 EKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDS 138
+ AC + + + L K I Y E D + +E E +K + L ++
Sbjct: 1434 QSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKE---TKALSLARALEEAME 1490
Query: 139 RKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESR 198
+K ++E+ N + +ME + D+ + H +++ R E+++ + +LE+L E +
Sbjct: 1491 QKAELERLNKQFRTEMEDLMSSKDD-VGKSVHELEKSKRALEQQVEEMKTQLEELEDELQ 1549
Query: 199 LLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFH 258
E +L+L+ + +Q++ Q E D R SE + K
Sbjct: 1550 A---------TEDAKLRLEVN------------LQAMKAQFERDLQGRDEQSEEKKK--- 1585
Query: 259 KLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNEL 318
+LVR+ +E EA+ ++ KQ+ + KK + + +L++ I S +N
Sbjct: 1586 QLVRQVREMEAELEDER----------KQRSMAVAARKKLEMD-LKDLEAHIDSANKNRD 1634
Query: 319 KNVKYELQQLEGS-SDRILELDQELIKAERELSKAEKNSN-VETLKMEVISLQNEKADLD 376
+ +K +L++L+ D + ELD E L++A++N +++++ E+I LQ E A +
Sbjct: 1635 EAIK-QLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAE 1693
Query: 377 RTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQ 436
R R+ QE ++L + L E+ R++++R + Q
Sbjct: 1694 RAKRQAQQERDELADEIANSSGKGALAL------EEKRRLEARIA--------------Q 1733
Query: 437 LEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGS 496
LE+ L + DRL K N ++ + IN +L + E+
Sbjct: 1734 LEEELEEEQGNTELINDRLKKANLQI-------DQINTDLNLERSHAQKNEN------AR 1780
Query: 497 QDFESDLDRLKEEIEK-----SSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQT 551
Q E LK ++++ SK +A + A +Q QL +E + C++V +T
Sbjct: 1781 QQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRT 1840
Query: 552 EAELQEVISDLQSKLRLA---PDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEI 608
E +L++V+ + + R A D+ + LK+ +++ +E + ++E+
Sbjct: 1841 EKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQREL 1900
Query: 609 PELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAK 647
+ +NR++ LKN + + L ++P + K
Sbjct: 1901 EDATETADAMNREVSSLKNKLRRGD--LPFVVPRRMARK 1937
Score = 99.8 bits (247), Expect = 1e-20
Identities = 139/683 (20%), Positives = 294/683 (43%), Gaps = 106/683 (15%)
Query: 325 LQQLEGSSDRILELDQELIKA-ERELSKAEKNSNVETLKMEVISLQNEKADLDRTLR--- 380
L Q+ + ++ ++EL+K E++L+ + + +ETL+ ++++ EK L L+
Sbjct: 837 LLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMA---EKLQLQEQLQAET 893
Query: 381 KLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDW 440
+L E E+L T + K++LE+
Sbjct: 894 ELCAEAEELRARLTAK-------------------------------------KQELEEI 916
Query: 441 LHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYE-DKLFDVCGSQDF 499
H + + +R L E +QN + +L+ +E + +K+ +
Sbjct: 917 CHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKL 976
Query: 500 ESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVI 559
E + L+++ K +K++ +L A +F T LT+E + + + + EA +I
Sbjct: 977 EEEQIILEDQNCKLAKEKKLLEDRIA---EFTTNLTEEEEKSKSLAKLKNKHEA----MI 1029
Query: 560 SDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVN 619
+DL+ +LR E + ++ EK R ++ G DL + +I EL+ ++ +
Sbjct: 1030 TDLEERLR-------REEKQRQELEKTRRKLEG------DSTDLSD-QIAELQAQIAELK 1075
Query: 620 RDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMEL-KDVE-RKIAQQAAKL 677
+ + + EE + L + E + L + +E EL +D+E + ++ A+
Sbjct: 1076 MQLAKKE---EELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEK 1132
Query: 678 QGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKST-TNELKSEKL 736
Q DL ++ + K E + LD+ +++ EL K +++++ LK T E K+ +
Sbjct: 1133 QKRDLGEELEAL---KTELEDTLDSTAAQQELRSK----REQEVNILKKTLEEEAKTHEA 1185
Query: 737 QISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNT 796
QI Q+ Q E+ E +++ K + LE + + E+ EL N+
Sbjct: 1186 QIQEMRQKHSQAVEELAE----------QLEQTKRVKANLEKAKQTLENERGELANEV-- 1233
Query: 797 SNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGK------DDYKKQKETELNKVIAQLSE 850
K+ D + K K + +++++ +G+ D + + EL+ V LS+
Sbjct: 1234 --KVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQ 1291
Query: 851 CEKHKEKINEDMRLMRQDI-DTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQM 909
+ K+ +D + + DTQ++ + + L+L + +LK+VE+E+ +++ +
Sbjct: 1292 SDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSL---STKLKQVEDEKNSFREQLEEE 1348
Query: 910 QVLQMKSEHQ--KLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKYRE 967
+ + E Q L + ++K+ ++G + EE +K+L E + EEK
Sbjct: 1349 EEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDL-EGLSQRHEEKVAA 1407
Query: 968 MMIVMRTTELVNKDLDIYYKTLD 990
+ +T + ++LD LD
Sbjct: 1408 YDKLEKTKTRLQQELDDLLVDLD 1430
Score = 75.5 bits (184), Expect = 3e-13
Identities = 89/418 (21%), Positives = 190/418 (45%), Gaps = 70/418 (16%)
Query: 601 IDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQ 660
+ +E+E+ +L V +N + E ETL +M E+ + + E+ Q
Sbjct: 840 VSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEK---------LQLQEQLQ 890
Query: 661 MELK---DVERKIAQQAAKLQGID-LDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQD 716
E + + E A+ AK Q ++ + ++ +E++E+ L K++ N IQ+
Sbjct: 891 AETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQN---IQE 947
Query: 717 QQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPL 776
+EQ++ +S +L+ EK+ L++ LEE+ + L + L +E K +++++
Sbjct: 948 LEEQLEEEESARQKLQLEKVTTEAKLKK---LEEEQIILEDQNCKLAKEKKLLEDRIAEF 1004
Query: 777 ETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQ 836
T L + +++ + L KN + + D++E+++ +KQ
Sbjct: 1005 TTNLTEEEEKSKSLAKLKNKHEAM----ITDLEERLRR------------------EEKQ 1042
Query: 837 KETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELK--- 893
++ E EK + K+ D + I ++Q + + + L K+ EEL+
Sbjct: 1043 RQ-----------ELEKTRRKLEGDSTDLSDQI--AELQAQIAELKMQLAKKEEELQAAL 1089
Query: 894 -EVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKE 952
VEEE Q K M ++ +++S+ +L+E++++ + + N A +++ EE+ K E
Sbjct: 1090 ARVEEEAAQ--KNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTE 1147
Query: 953 LRE------PQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEI 1004
L + Q ++ +E+ I+ +T E K ++ Q + + HS +EE+
Sbjct: 1148 LEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKT----HEAQIQEMRQKHSQAVEEL 1201
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 132 bits (331), Expect = 3e-30
Identities = 203/1046 (19%), Positives = 459/1046 (43%), Gaps = 187/1046 (17%)
Query: 51 ETLRQVRQTQGQKVK-EYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENEL 109
E L + Q +K + Q+E K +K+ E+A E ++I A+LT+ K + E+E
Sbjct: 902 EGLADAEERCDQLIKTKIQLEAK-IKEVTERA-EDEEEIN---AELTAKK---RKLEDEC 953
Query: 110 DPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLY 169
LK + ++E L+K+ K E A +++ K + ++ + L+E + K+ ++ L
Sbjct: 954 SELKKDIDDLELTLAKVEK---EKHATENKVKNLTEEMAGLDETIAKL----TKEKKALQ 1006
Query: 170 HNHQRTVREKERKLVDCHRELEKLNK---------------ESRLLNQEKSELLVEQGRL 214
HQ+T L D E +K+N E L ++K + +E+ +
Sbjct: 1007 EAHQQT-------LDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKR 1059
Query: 215 QLQAD----------------RHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFH 258
+L+ D + E ++ ++ I +L +++E D G +++IK
Sbjct: 1060 KLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIE-DEQALGIQLQKKIKELQ 1118
Query: 259 KLVRE-RQEGEAKTANQLMNDFAEKETLK-QKQIDEIRDKKTGLGRIIELKSEILSKKQN 316
+ E +E EA+ A++ AEK+ ++++EI ++ G + E+ K++
Sbjct: 1119 ARIEELEEEIEAERASRAK---AEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREA 1175
Query: 317 ELKNVKYELQQL------------EGSSDRILELDQEL-----IKAERELSKAEKNSNVE 359
E + ++ +L++ + +D + EL +++ +K + E K+E ++
Sbjct: 1176 EFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEID 1235
Query: 360 TLKMEVISLQNEKADLDRTLRKLDQEMEQL-----------NHHTTTRTQMEMLTKD--- 405
L V ++ K +L++ R L+ ++ +L N T R +++ + +
Sbjct: 1236 DLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSR 1295
Query: 406 KADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSK---SKEINQTRDRLAKLNKEL 462
+ D+ E + SR T + K+QLE+ + +K + + +R L ++
Sbjct: 1296 QLDEKEALVSQLSRGKQAFTQQIEEL--KRQLEEEIKAKNALAHALQSSRHDCDLLREQY 1353
Query: 463 ASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAG 522
+++K + L + +++ + K +E+D + EE+E++ K+ A
Sbjct: 1354 EEEQESKAELQRALSKANTEVAQWRTK---------YETDAIQRTEELEEAKKKLAQRLQ 1404
Query: 523 ATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKK 582
A + + + C + +T+ LQ + DL L ++ + + L K
Sbjct: 1405 AAEEHVEAVN----------AKCASLEKTKQRLQNEVEDLM----LDVERTNAACAALDK 1450
Query: 583 KEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPE 642
K++ D++L + + E+ + + +++ ++ ++KN EE L T+ E
Sbjct: 1451 KQRNFDKILAEWKQK---CEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRE 1507
Query: 643 EESAKVCLTDVT--IMERFQM--ELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQH 698
++ + ++D+T I E + EL+ +++++ Q+ +LQ + ++E + +
Sbjct: 1508 NKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRI 1567
Query: 699 KLDTVSSKIELNRKLIQDQQE----------QIQHLKSTTN-ELKSEKLQISTNLQRRQQ 747
+L+ K E++RK+ + +E ++ ++ST + E++S I +
Sbjct: 1568 QLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGD 1627
Query: 748 LEEQTVELS------------------------TEVQSLYREIKDAKEQVSPLETTLEKF 783
L E ++L+ + R +D KEQ++ +E
Sbjct: 1628 LNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLL 1687
Query: 784 QQEKEEL---INKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETE 840
Q E EEL + + S KIA+ +L D E+V+ +H + N + + D Q + E
Sbjct: 1688 QAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDI-SQMQGE 1746
Query: 841 LNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEE--LKEVE-- 896
+ ++ + E+ +K D +M +++ +E+ +L K+N E +K+++
Sbjct: 1747 MEDILQEARNAEEKAKKAITDAAMMAEELK----KEQDTSAHLERMKKNMEQTVKDLQLR 1802
Query: 897 -EERKQHLKEMGQMQVLQMKSEHQKLEENIDN-IKRNHNLALGRQKGYEEEIIHFKKELR 954
+E +Q + G+ Q+ ++++ ++LE +++ KRN G +K ++ ++
Sbjct: 1803 LDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRK--------HERRVK 1854
Query: 955 EPQFRDAEEKYREMMIVMRTTELVNK 980
E ++ E++ ++R +LV+K
Sbjct: 1855 ELTYQTEEDRKN----ILRLQDLVDK 1876
Score = 128 bits (322), Expect = 3e-29
Identities = 182/837 (21%), Positives = 365/837 (43%), Gaps = 113/837 (13%)
Query: 255 KNFHKLVRERQEGEAKTAN---QLMNDFAEKETLK---QKQIDEIRDKKTGLGRIIELKS 308
+ F K+ E + EAK +++ EK L+ Q + + + D + ++I+ K
Sbjct: 860 EEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKI 919
Query: 309 EILSK------KQNELKNVKYELQQLEGS-SDRILELDQELIKAERELSKAEKNSNVETL 361
++ +K + + + + EL + D EL +++ E L+K EK +
Sbjct: 920 QLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATEN 979
Query: 362 KMEVISLQNEKADLDRTLRKLDQEMEQLNH-HTTTRTQMEMLTKDKADKDEQIRKIKSRH 420
K++ +L E A LD T+ KL +E + L H T ++ + DK + K K +
Sbjct: 980 KVK--NLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQA----EEDKVNTLTKAKIKL 1033
Query: 421 SDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKE 480
++ L G +K+L L +++ L + + E K ++ +LK+KE
Sbjct: 1034 EQQVDDLEGSLEQEKKLRMDLERAKRKLEGD---LKLAQESIMDIENEKQQLDEKLKKKE 1090
Query: 481 EQLSSYEDKLFD--VCGSQ------DFESDLDRLKEEIE-------KSSKQRAMLAGATA 525
++S+ + K+ D G Q + ++ ++ L+EEIE K+ KQR+ L+
Sbjct: 1091 FEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELE 1150
Query: 526 VYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEK 585
S+ +L + + + + EAE Q++ DL+ A + ++T + L+KK
Sbjct: 1151 EISE---RLEEAGGATSAQIEMNKKREAEFQKMRRDLEE----ATLQHEATAATLRKKHA 1203
Query: 586 RRDEMLG-LVPMRQSIIDLKEKEIPELRNKLQNVNRDIQ---RLKNDIEEQ----ETLLG 637
LG + Q + EKE E++ ++ ++ +++ + K ++E+ E L
Sbjct: 1204 DSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLS 1263
Query: 638 TIMPEEESAKVCLTDVTIME--------RFQMELKDVERKIAQ-----QAAKLQGIDLDR 684
+ +EE + + D+T F +L + E ++Q QA Q +L R
Sbjct: 1264 ELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKR 1323
Query: 685 TVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTN--- 741
+++ + K H L + +L R+ +++QE L+ ++ +E Q T
Sbjct: 1324 QLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYET 1383
Query: 742 --LQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNK 799
+QR ++LEE +L+ +Q+ ++ + + LE T ++ Q E E+L+ +N
Sbjct: 1384 DAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNA 1443
Query: 800 --IAQDK--------LNDIKEKVKNIHGYMKDIENYIQD-GKDDYKKQKETELNKVIAQL 848
A DK L + K+K + H ++ + + G + +K + E + + QL
Sbjct: 1444 ACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYE--ESLDQL 1501
Query: 849 SECEKHKEKINEDMRLMRQDI--------DTQKIQERWLQDNLTLRKRNEELKEVEEERK 900
++ + + +++ + + I + +KI+++ Q+ L+ EE + E +
Sbjct: 1502 ETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEE 1561
Query: 901 QHLKEMGQMQVLQMKSEHQK----LEENIDNIKRNH-NLALGRQKGYEEEI------IHF 949
+ + Q+++ Q+KSE + +E ID +KRNH + Q + EI I
Sbjct: 1562 GKILRI-QLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRL 1620
Query: 950 KKELR------EPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMK 1000
KK++ E Q A E + R T+ + KD I+ LD A+ +K
Sbjct: 1621 KKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIH---LDDALRSQEDLK 1674
Score = 89.7 bits (221), Expect = 1e-17
Identities = 139/788 (17%), Positives = 328/788 (41%), Gaps = 87/788 (11%)
Query: 50 LETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENEL 109
++ L++V+Q ++ E +ME+ L E + + + +++ ++ E++L
Sbjct: 1213 IDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNL----------EKMCRTLEDQL 1262
Query: 110 DPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLY 169
LK++ +E + ++ + ++ + + L ++ + Q +Q+ +L
Sbjct: 1263 SELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELK 1322
Query: 170 HNHQRTVREKE---RKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIR 226
+ ++ K L + + L ++ + K+EL Q +
Sbjct: 1323 RQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAEL--------------QRALS 1368
Query: 227 ARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLK 286
++ + T+ E D +R +++ K + +R + + + A E K
Sbjct: 1369 KANTEVAQWRTKYETDAIQR----TEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTK 1424
Query: 287 QKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQ--------LEGSSDRILEL 338
Q+ +E+ D + R L KKQ + E +Q LE S L
Sbjct: 1425 QRLQNEVEDLMLDVER-TNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSL 1483
Query: 339 DQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQ 398
EL K + + E +ETLK E +LQ E +DL + + + + +L + Q
Sbjct: 1484 GTELFKIKN--AYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELE---KIKKQ 1538
Query: 399 MEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKL 458
+E ++K + + + ++ E +L Q++ + K E ++ D+L +
Sbjct: 1539 VE---QEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRN 1595
Query: 459 NKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRA 518
+ + S Q+ ++ E++ + + + + E DL+ ++ ++ +++
Sbjct: 1596 HIRIVESMQST--LDAEIRSRNDAIRL----------KKKMEGDLNEMEIQLNHANR--- 1640
Query: 519 MLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAP---DKLKS 575
M A A Y L D +++ +L+E ++ ++ + L ++L++
Sbjct: 1641 MAAEALRNYRNTQGILKDTQIH----LDDALRSQEDLKEQLAMVERRANLLQAEIEELRA 1696
Query: 576 TESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETL 635
T + ++ K ++ L R ++ + + + KL+ DI +++ ++E+ +
Sbjct: 1697 TLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLET---DISQMQGEMED---I 1750
Query: 636 LGTIMPEEESAKVCLTDVTIMERFQMELKDVE------RKIAQQAAKLQGIDLDRTVQQV 689
L EE AK +TD +M + +D +K +Q K + LD Q
Sbjct: 1751 LQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLA 1810
Query: 690 NQEKQEKQHKLDTVSSKIELNRKLIQDQQ-EQIQHLKSTTNELKSEKLQISTNLQRRQQL 748
+ +++ KL+ ++E + Q + E ++ L+ +K Q + + +L
Sbjct: 1811 LKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRL 1870
Query: 749 EEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDI 808
++ +L +V+S R+ ++A+EQ + T L KF++ + EL + ++ IA+ ++N +
Sbjct: 1871 QDLVDKLQAKVKSYKRQAEEAEEQSN---TNLAKFRKLQHELEEAEERAD-IAESQVNKL 1926
Query: 809 KEKVKNIH 816
+ K + +H
Sbjct: 1927 RVKSREVH 1934
Score = 82.4 bits (202), Expect = 2e-15
Identities = 103/512 (20%), Positives = 219/512 (42%), Gaps = 74/512 (14%)
Query: 456 AKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSK 515
A+ KE+A+ ++ I +EL + E + E+K+ + LKE+ + +
Sbjct: 849 AETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTL------------LKEKNDLQLQ 896
Query: 516 QRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVIS------DLQSKLRLA 569
+A G L D + C + + Q EA+++EV ++ ++L
Sbjct: 897 VQAEAEG-----------LADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAK 945
Query: 570 PDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDI 629
KL+ SELKK + L V + + K K + E L + + K +
Sbjct: 946 KRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKAL 1005
Query: 630 EE-QETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAA----------KLQ 678
+E + L + EE+ LT I + + ++ D+E + Q+ KL+
Sbjct: 1006 QEAHQQTLDDLQAEEDKVNT-LTKAKI--KLEQQVDDLEGSLEQEKKLRMDLERAKRKLE 1062
Query: 679 G---------IDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTN 729
G +D++ QQ++++ ++K+ ++ + SKIE + L Q++I+ L++
Sbjct: 1063 GDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIE 1122
Query: 730 ELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAK-------EQVSPLETTLEK 782
EL+ E I R + E+Q +LS E++ + +++A E E +K
Sbjct: 1123 ELEEE---IEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQK 1179
Query: 783 FQQEKEELINKKN----TSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKE 838
+++ EE + T K D + ++ E++ N+ + +E + K +
Sbjct: 1180 MRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEK-----EKSEMKMEI 1234
Query: 839 TELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEE 898
+L + +S+ + + EK+ + ++ +++ +++ L ++LT ++ + + E
Sbjct: 1235 DDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFS 1294
Query: 899 RKQHLKEMGQMQVLQMKSEHQKLEENIDNIKR 930
R+ KE V Q+ Q + I+ +KR
Sbjct: 1295 RQLDEKE---ALVSQLSRGKQAFTQQIEELKR 1323
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 132 bits (331), Expect = 3e-30
Identities = 203/1046 (19%), Positives = 459/1046 (43%), Gaps = 187/1046 (17%)
Query: 51 ETLRQVRQTQGQKVK-EYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENEL 109
E L + Q +K + Q+E K +K+ E+A E ++I A+LT+ K + E+E
Sbjct: 902 EGLADAEERCDQLIKTKIQLEAK-IKEVTERA-EDEEEIN---AELTAKK---RKLEDEC 953
Query: 110 DPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLY 169
LK + ++E L+K+ K E A +++ K + ++ + L+E + K+ ++ L
Sbjct: 954 SELKKDIDDLELTLAKVEK---EKHATENKVKNLTEEMAGLDETIAKL----TKEKKALQ 1006
Query: 170 HNHQRTVREKERKLVDCHRELEKLNK---------------ESRLLNQEKSELLVEQGRL 214
HQ+T L D E +K+N E L ++K + +E+ +
Sbjct: 1007 EAHQQT-------LDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKR 1059
Query: 215 QLQAD----------------RHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFH 258
+L+ D + E ++ ++ I +L +++E D G +++IK
Sbjct: 1060 KLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIE-DEQALGIQLQKKIKELQ 1118
Query: 259 KLVRE-RQEGEAKTANQLMNDFAEKETLK-QKQIDEIRDKKTGLGRIIELKSEILSKKQN 316
+ E +E EA+ A++ AEK+ ++++EI ++ G + E+ K++
Sbjct: 1119 ARIEELEEEIEAERASRAK---AEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREA 1175
Query: 317 ELKNVKYELQQL------------EGSSDRILELDQEL-----IKAERELSKAEKNSNVE 359
E + ++ +L++ + +D + EL +++ +K + E K+E ++
Sbjct: 1176 EFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEID 1235
Query: 360 TLKMEVISLQNEKADLDRTLRKLDQEMEQL-----------NHHTTTRTQMEMLTKD--- 405
L V ++ K +L++ R L+ ++ +L N T R +++ + +
Sbjct: 1236 DLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSR 1295
Query: 406 KADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSK---SKEINQTRDRLAKLNKEL 462
+ D+ E + SR T + K+QLE+ + +K + + +R L ++
Sbjct: 1296 QLDEKEALVSQLSRGKQAFTQQIEEL--KRQLEEEIKAKNALAHALQSSRHDCDLLREQY 1353
Query: 463 ASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAG 522
+++K + L + +++ + K +E+D + EE+E++ K+ A
Sbjct: 1354 EEEQESKAELQRALSKANTEVAQWRTK---------YETDAIQRTEELEEAKKKLAQRLQ 1404
Query: 523 ATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKK 582
A + + + C + +T+ LQ + DL L ++ + + L K
Sbjct: 1405 AAEEHVEAVN----------AKCASLEKTKQRLQNEVEDLM----LDVERTNAACAALDK 1450
Query: 583 KEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPE 642
K++ D++L + + E+ + + +++ ++ ++KN EE L T+ E
Sbjct: 1451 KQRNFDKILAEWKQK---CEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRE 1507
Query: 643 EESAKVCLTDVT--IMERFQM--ELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQH 698
++ + ++D+T I E + EL+ +++++ Q+ +LQ + ++E + +
Sbjct: 1508 NKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRI 1567
Query: 699 KLDTVSSKIELNRKLIQDQQE----------QIQHLKSTTN-ELKSEKLQISTNLQRRQQ 747
+L+ K E++RK+ + +E ++ ++ST + E++S I +
Sbjct: 1568 QLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGD 1627
Query: 748 LEEQTVELS------------------------TEVQSLYREIKDAKEQVSPLETTLEKF 783
L E ++L+ + R +D KEQ++ +E
Sbjct: 1628 LNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLL 1687
Query: 784 QQEKEEL---INKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETE 840
Q E EEL + + S KIA+ +L D E+V+ +H + N + + D Q + E
Sbjct: 1688 QAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDI-SQMQGE 1746
Query: 841 LNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEE--LKEVE-- 896
+ ++ + E+ +K D +M +++ +E+ +L K+N E +K+++
Sbjct: 1747 MEDILQEARNAEEKAKKAITDAAMMAEELK----KEQDTSAHLERMKKNMEQTVKDLQLR 1802
Query: 897 -EERKQHLKEMGQMQVLQMKSEHQKLEENIDN-IKRNHNLALGRQKGYEEEIIHFKKELR 954
+E +Q + G+ Q+ ++++ ++LE +++ KRN G +K ++ ++
Sbjct: 1803 LDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRK--------HERRVK 1854
Query: 955 EPQFRDAEEKYREMMIVMRTTELVNK 980
E ++ E++ ++R +LV+K
Sbjct: 1855 ELTYQTEEDRKN----ILRLQDLVDK 1876
Score = 128 bits (322), Expect = 3e-29
Identities = 182/837 (21%), Positives = 365/837 (43%), Gaps = 113/837 (13%)
Query: 255 KNFHKLVRERQEGEAKTAN---QLMNDFAEKETLK---QKQIDEIRDKKTGLGRIIELKS 308
+ F K+ E + EAK +++ EK L+ Q + + + D + ++I+ K
Sbjct: 860 EEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKI 919
Query: 309 EILSK------KQNELKNVKYELQQLEGS-SDRILELDQELIKAERELSKAEKNSNVETL 361
++ +K + + + + EL + D EL +++ E L+K EK +
Sbjct: 920 QLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATEN 979
Query: 362 KMEVISLQNEKADLDRTLRKLDQEMEQLNH-HTTTRTQMEMLTKDKADKDEQIRKIKSRH 420
K++ +L E A LD T+ KL +E + L H T ++ + DK + K K +
Sbjct: 980 KVK--NLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQA----EEDKVNTLTKAKIKL 1033
Query: 421 SDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKE 480
++ L G +K+L L +++ L + + E K ++ +LK+KE
Sbjct: 1034 EQQVDDLEGSLEQEKKLRMDLERAKRKLEGD---LKLAQESIMDIENEKQQLDEKLKKKE 1090
Query: 481 EQLSSYEDKLFD--VCGSQ------DFESDLDRLKEEIE-------KSSKQRAMLAGATA 525
++S+ + K+ D G Q + ++ ++ L+EEIE K+ KQR+ L+
Sbjct: 1091 FEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELE 1150
Query: 526 VYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEK 585
S+ +L + + + + EAE Q++ DL+ A + ++T + L+KK
Sbjct: 1151 EISE---RLEEAGGATSAQIEMNKKREAEFQKMRRDLEE----ATLQHEATAATLRKKHA 1203
Query: 586 RRDEMLG-LVPMRQSIIDLKEKEIPELRNKLQNVNRDIQ---RLKNDIEEQ----ETLLG 637
LG + Q + EKE E++ ++ ++ +++ + K ++E+ E L
Sbjct: 1204 DSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLS 1263
Query: 638 TIMPEEESAKVCLTDVTIME--------RFQMELKDVERKIAQ-----QAAKLQGIDLDR 684
+ +EE + + D+T F +L + E ++Q QA Q +L R
Sbjct: 1264 ELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKR 1323
Query: 685 TVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTN--- 741
+++ + K H L + +L R+ +++QE L+ ++ +E Q T
Sbjct: 1324 QLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYET 1383
Query: 742 --LQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNK 799
+QR ++LEE +L+ +Q+ ++ + + LE T ++ Q E E+L+ +N
Sbjct: 1384 DAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNA 1443
Query: 800 --IAQDK--------LNDIKEKVKNIHGYMKDIENYIQD-GKDDYKKQKETELNKVIAQL 848
A DK L + K+K + H ++ + + G + +K + E + + QL
Sbjct: 1444 ACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYE--ESLDQL 1501
Query: 849 SECEKHKEKINEDMRLMRQDI--------DTQKIQERWLQDNLTLRKRNEELKEVEEERK 900
++ + + +++ + + I + +KI+++ Q+ L+ EE + E +
Sbjct: 1502 ETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEE 1561
Query: 901 QHLKEMGQMQVLQMKSEHQK----LEENIDNIKRNH-NLALGRQKGYEEEI------IHF 949
+ + Q+++ Q+KSE + +E ID +KRNH + Q + EI I
Sbjct: 1562 GKILRI-QLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRL 1620
Query: 950 KKELR------EPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMK 1000
KK++ E Q A E + R T+ + KD I+ LD A+ +K
Sbjct: 1621 KKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIH---LDDALRSQEDLK 1674
Score = 89.7 bits (221), Expect = 1e-17
Identities = 139/788 (17%), Positives = 328/788 (41%), Gaps = 87/788 (11%)
Query: 50 LETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENEL 109
++ L++V+Q ++ E +ME+ L E + + + +++ ++ E++L
Sbjct: 1213 IDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNL----------EKMCRTLEDQL 1262
Query: 110 DPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLY 169
LK++ +E + ++ + ++ + + L ++ + Q +Q+ +L
Sbjct: 1263 SELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELK 1322
Query: 170 HNHQRTVREKE---RKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIR 226
+ ++ K L + + L ++ + K+EL Q +
Sbjct: 1323 RQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAEL--------------QRALS 1368
Query: 227 ARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLK 286
++ + T+ E D +R +++ K + +R + + + A E K
Sbjct: 1369 KANTEVAQWRTKYETDAIQR----TEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTK 1424
Query: 287 QKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQ--------LEGSSDRILEL 338
Q+ +E+ D + R L KKQ + E +Q LE S L
Sbjct: 1425 QRLQNEVEDLMLDVER-TNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSL 1483
Query: 339 DQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQ 398
EL K + + E +ETLK E +LQ E +DL + + + + +L + Q
Sbjct: 1484 GTELFKIKN--AYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELE---KIKKQ 1538
Query: 399 MEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKL 458
+E ++K + + + ++ E +L Q++ + K E ++ D+L +
Sbjct: 1539 VE---QEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRN 1595
Query: 459 NKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRA 518
+ + S Q+ ++ E++ + + + + E DL+ ++ ++ +++
Sbjct: 1596 HIRIVESMQST--LDAEIRSRNDAIRL----------KKKMEGDLNEMEIQLNHANR--- 1640
Query: 519 MLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAP---DKLKS 575
M A A Y L D +++ +L+E ++ ++ + L ++L++
Sbjct: 1641 MAAEALRNYRNTQGILKDTQIH----LDDALRSQEDLKEQLAMVERRANLLQAEIEELRA 1696
Query: 576 TESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETL 635
T + ++ K ++ L R ++ + + + KL+ DI +++ ++E+ +
Sbjct: 1697 TLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLET---DISQMQGEMED---I 1750
Query: 636 LGTIMPEEESAKVCLTDVTIMERFQMELKDVE------RKIAQQAAKLQGIDLDRTVQQV 689
L EE AK +TD +M + +D +K +Q K + LD Q
Sbjct: 1751 LQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLA 1810
Query: 690 NQEKQEKQHKLDTVSSKIELNRKLIQDQQ-EQIQHLKSTTNELKSEKLQISTNLQRRQQL 748
+ +++ KL+ ++E + Q + E ++ L+ +K Q + + +L
Sbjct: 1811 LKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRL 1870
Query: 749 EEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDI 808
++ +L +V+S R+ ++A+EQ + T L KF++ + EL + ++ IA+ ++N +
Sbjct: 1871 QDLVDKLQAKVKSYKRQAEEAEEQSN---TNLAKFRKLQHELEEAEERAD-IAESQVNKL 1926
Query: 809 KEKVKNIH 816
+ K + +H
Sbjct: 1927 RVKSREVH 1934
Score = 82.4 bits (202), Expect = 2e-15
Identities = 103/512 (20%), Positives = 219/512 (42%), Gaps = 74/512 (14%)
Query: 456 AKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSK 515
A+ KE+A+ ++ I +EL + E + E+K+ + LKE+ + +
Sbjct: 849 AETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTL------------LKEKNDLQLQ 896
Query: 516 QRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVIS------DLQSKLRLA 569
+A G L D + C + + Q EA+++EV ++ ++L
Sbjct: 897 VQAEAEG-----------LADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAK 945
Query: 570 PDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDI 629
KL+ SELKK + L V + + K K + E L + + K +
Sbjct: 946 KRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKAL 1005
Query: 630 EE-QETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAA----------KLQ 678
+E + L + EE+ LT I + + ++ D+E + Q+ KL+
Sbjct: 1006 QEAHQQTLDDLQAEEDKVNT-LTKAKI--KLEQQVDDLEGSLEQEKKLRMDLERAKRKLE 1062
Query: 679 G---------IDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTN 729
G +D++ QQ++++ ++K+ ++ + SKIE + L Q++I+ L++
Sbjct: 1063 GDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIE 1122
Query: 730 ELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAK-------EQVSPLETTLEK 782
EL+ E I R + E+Q +LS E++ + +++A E E +K
Sbjct: 1123 ELEEE---IEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQK 1179
Query: 783 FQQEKEELINKKN----TSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKE 838
+++ EE + T K D + ++ E++ N+ + +E + K +
Sbjct: 1180 MRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEK-----EKSEMKMEI 1234
Query: 839 TELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEE 898
+L + +S+ + + EK+ + ++ +++ +++ L ++LT ++ + + E
Sbjct: 1235 DDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFS 1294
Query: 899 RKQHLKEMGQMQVLQMKSEHQKLEENIDNIKR 930
R+ KE V Q+ Q + I+ +KR
Sbjct: 1295 RQLDEKE---ALVSQLSRGKQAFTQQIEELKR 1323
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 131 bits (329), Expect = 4e-30
Identities = 200/961 (20%), Positives = 418/961 (43%), Gaps = 136/961 (14%)
Query: 51 ETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELD 110
E LR R + + + + L++Y+ + + + ++ S E ++ KS + LD
Sbjct: 1039 EELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLD 1098
Query: 111 PLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELE---EKMEKVFQGTDEQLND 167
++KE+ KI +L EI+ R+K +E + + ++++K Q E L
Sbjct: 1099 KCYGQIKELNE---KITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGW 1155
Query: 168 LYHNHQRTVREKERKLVDCH----------RELE-KLNKESRLLNQEKSELLVE-QGRLQ 215
++ ++EKE ++ RE E +L K N+E S L + + +
Sbjct: 1156 QKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEIN 1215
Query: 216 LQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQL 275
+ +E ++ ++L QL+ E + ++ +++ ++ N L
Sbjct: 1216 ITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENAL 1275
Query: 276 MNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRI 335
E +++KQ EI L ++++ +SE ++ + L+ +Q +R+
Sbjct: 1276 QQKACGSEIMQKKQHLEIE-----LKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERL 1330
Query: 336 LELDQELIKA----ERELSKAEKNSNVETLKMEVISLQNE-KADLDRTLRKLDQEMEQLN 390
QE K E ELSK N + E +ISL+N+ + +++ T + Q Q
Sbjct: 1331 KAEFQEEAKRRWEYENELSKVRNNYDEE-----IISLKNQFETEINITKTTIHQLTMQKE 1385
Query: 391 HHTTT-RTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEIN 449
T+ R Q++ LT++ E+I+++K+ +L N +++E+ + + +
Sbjct: 1386 EDTSGYRAQIDNLTRENRSLSEEIKRLKN-------TLTQTTENLRRVEEDIQQQKATGS 1438
Query: 450 QTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGS-QDFESDLDRLKE 508
+ R +L EL Q + E+ Y+ L D + QD +++RLK+
Sbjct: 1439 EVSQRKQQLEVELRQVTQMRT----------EESVRYKQSLDDAAKTIQDKNKEIERLKQ 1488
Query: 509 EIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAEL------------- 555
I+K + R L A + L N S ++ E EL
Sbjct: 1489 LIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQE 1548
Query: 556 -----------QEVISDLQ---SKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSII 601
Q + +LQ K+ ++LK T SE K K+ +E L MR+S
Sbjct: 1549 RTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELE--GMRRS-- 1604
Query: 602 DLKEK--EIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERF 659
LKE+ +I L +L+ + +R ++D+ +Q +L + E++ + L R
Sbjct: 1605 -LKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEEL------RRL 1657
Query: 660 QMELKDVERKIAQQA-----AKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLI 714
E++ + R++ Q+ A L+ + ++ ++ E + +++ + S E K
Sbjct: 1658 SSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEH 1717
Query: 715 QDQQEQIQHLKSTTNELKSEKLQI-----STNLQRRQQLE---EQTVELSTEVQSLYREI 766
+E++++L+ ++L+ + + +T L+ R QL+ +T+EL + L RE
Sbjct: 1718 LMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRER 1777
Query: 767 KDAKEQVSPLETTLEKFQQEKEELINK----KNTSNKIAQDKLNDIKEKVKNIHGYMKDI 822
++ ++++ EKFQ++ E N+ KN ++ Q++ + K+K ++
Sbjct: 1778 ENLRQEI-------EKFQKQALEASNRIQESKNQCTQVVQER-ESLLVKIK----VLEQD 1825
Query: 823 ENYIQDGKDDYKKQKET-ELNKVIAQLSECEKHKEKINEDM-----RLMRQDIDTQKIQ- 875
+ +Q +D+ + K T E + Q ECEK ++I D+ + R++ +KI+
Sbjct: 1826 KARLQRLEDELNRAKSTLEAETRVKQRLECEK--QQIQNDLNQWKTQYSRKEEAIRKIES 1883
Query: 876 --ERWLQDNLTLRKRNE----ELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIK 929
E+ ++ +LR E E+K +EE ++ L++ + Q+++E + + ID ++
Sbjct: 1884 EREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLR 1943
Query: 930 R 930
+
Sbjct: 1944 Q 1944
Score = 128 bits (321), Expect = 4e-29
Identities = 195/1043 (18%), Positives = 446/1043 (42%), Gaps = 107/1043 (10%)
Query: 51 ETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEI---RDQITSKEAQLTSSKEIVKS--- 104
E ++++ + +K+Y+++L E I R I S + V +
Sbjct: 945 EEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYI 1004
Query: 105 --------YENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEK 156
Y L + L++++ +KI L+ E++ + N L++ ++K
Sbjct: 1005 ELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQK 1064
Query: 157 V------FQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKE-SRL---LNQEKSE 206
F+ L +L + + ++ L C+ ++++LN++ +RL + EK
Sbjct: 1065 YQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRR 1124
Query: 207 LLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQE 266
+ R Q + + + +AR ++L Q +L+ + E +I+ L++E
Sbjct: 1125 RKSVEDRFDQQKNDYDQLQKARQCEKENLGWQ-KLESEKAIKEKEYEIERLRVLLQEEGT 1183
Query: 267 GEAKTANQLM---NDFAEK-ETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVK 322
+ + N+L N + E+ L+ K EI KT + EI +K+++ KN++
Sbjct: 1184 RKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTI-------KEISMQKEDDSKNLR 1236
Query: 323 YELQQLEGSS----DRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRT 378
+L +L + D I+ L+ +++A + +AE+N+ + K + +K L+
Sbjct: 1237 NQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQ--KACGSEIMQKKQHLEIE 1294
Query: 379 LRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLE 438
L+++ Q+ + N + +E K DK+++I ++K+ +E K+
Sbjct: 1295 LKQVMQQRSEDN--ARHKQSLEEAAKTIQDKNKEIERLKAEFQEEA----------KRRW 1342
Query: 439 DWLHSKSKEINQTRDRLAKLNKELASSEQ-NKNHINNELKRKEEQLSSYEDKLFDVCG-S 496
++ + SK N + + L + + K I+ +KEE S Y ++ ++ +
Sbjct: 1343 EYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTREN 1402
Query: 497 QDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQ 556
+ ++ RLK + ++++ + + + + V QR Q E EL+
Sbjct: 1403 RSLSEEIKRLKNTLTQTTENLRRVE----------EDIQQQKATGSEVSQRKQQLEVELR 1452
Query: 557 EVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQ 616
+V + L ++ K K + + L+ + K + + +LQ
Sbjct: 1453 QVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETN----DRKCLEDENARLQ 1508
Query: 617 NVNRDIQRLKND---------IEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVE 667
V D+Q+ + ++EQE I E S + + D I RFQ LK+++
Sbjct: 1509 RVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDIT-RFQNSLKELQ 1567
Query: 668 RKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHL--- 724
+ +Q + + L RT + + ++++ + +L+ + ++ I + +Q++
Sbjct: 1568 --LQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIV 1625
Query: 725 -KSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKF 783
K + ++L+ ++ + +L+ +Q+ +E+ LS+EV++L R++ +E V E F
Sbjct: 1626 KKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHF 1685
Query: 784 QQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKK---QKETE 840
Q+ E+ N S KI ++L + E + H +++ ++ DD ++ + +++
Sbjct: 1686 QKAIEDKSRSLNES-KIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSD 1744
Query: 841 LNKVIAQL-SECEKHKEKINE------DMRLMRQDI--DTQKIQERWLQDNLTLRKRNEE 891
N I +L S+ + + E D++ R+++ + +K Q++ L+ + +++ +
Sbjct: 1745 KNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQ 1804
Query: 892 LKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKK 951
+V +ER+ L ++ ++ Q K+ Q+LE+ ++ K ++ E E +
Sbjct: 1805 CTQVVQERESLLVKIKVLE--QDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQN 1862
Query: 952 ELRE--PQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIR 1009
+L + Q+ EE R++ +E L + L I + E + +
Sbjct: 1863 DLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIE----ERCRRKLE 1918
Query: 1010 DLWRSTYRGQDIEYIEIRSDADE 1032
D R T + E + + D+
Sbjct: 1919 DSTRETQSQLETERSRYQREIDK 1941
Score = 120 bits (302), Expect = 6e-27
Identities = 180/941 (19%), Positives = 392/941 (41%), Gaps = 146/941 (15%)
Query: 18 CHQEDSNWP-LSEGKALKQKFDEIFSATRYIKALETLRQVRQTQGQKVKEYQMEL-KYLK 75
C +E+ W L KA+K+K EI E LR + Q +G + +EY+ EL K
Sbjct: 1148 CEKENLGWQKLESEKAIKEKEYEI----------ERLRVLLQEEGTRKREYENELAKVRN 1197
Query: 76 QYKEKACEIRDQI-TSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHN----LSKIMKLD 130
Y E+ +R++ T T+ KEI E++ L+N+L + +I++L+
Sbjct: 1198 HYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLN 1257
Query: 131 NEIKALDSRKKQMEKD-------NSELEEK---MEKVFQGTDEQLNDLYHNHQRTVREKE 180
+ I ++++ E++ SE+ +K +E + +Q ++ H++++ E
Sbjct: 1258 DSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAA 1317
Query: 181 RKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRAR-DSLIQSLATQL 239
+ + D ++E+E+L E + E+ + + + + +R D I SL Q
Sbjct: 1318 KTIQDKNKEIERLKAEFQ-----------EEAKRRWEYENELSKVRNNYDEEIISLKNQF 1366
Query: 240 ELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTG 299
E + N K T +QL E + + QID + +
Sbjct: 1367 ETE------------INITKT----------TIHQLTMQKEEDTSGYRAQIDNLTRENRS 1404
Query: 300 LGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVE 359
L I+ L++ L+ V+ ++QQ + + + + Q+L R++++ +V
Sbjct: 1405 LSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVR 1464
Query: 360 TLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSR 419
+ D +T++ ++E+E+L T +D+ + ++++ +
Sbjct: 1465 --------YKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQK 1516
Query: 420 HSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRK 479
+ T + NK ++++ +E+ + R ++++E +Q+ N LK
Sbjct: 1517 ANSSATETI----NKLKVQE------QELTRLRIDYERVSQERTVKDQDITRFQNSLKEL 1566
Query: 480 EEQLSSYEDKLF--------DVCGSQDFESDLD----RLKEEIEKSSKQRAMLAGATAVY 527
+ Q E++L D C + E +L+ LKE+ K + L A+ V
Sbjct: 1567 QLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVK 1626
Query: 528 SQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRR 587
+ L + + +T+ EL+ + S++++ R +L + +K+ R
Sbjct: 1627 KRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRR----QLLQEQESVKQAHLRN 1682
Query: 588 DEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIM---PEEE 644
+ + + ++ + EI L++ +N+ ++ L+ ++ + E +
Sbjct: 1683 EHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEAD 1742
Query: 645 SAKVCLTDVTIME-RFQMELKDVERKIAQQAAKLQGI--DLDRTVQQVNQEKQEKQHKLD 701
S K + TI+E R Q+++ + + +LQG+ DL R + + QE ++ Q +
Sbjct: 1743 SDK----NATILELRSQLQISN------NRTLELQGLINDLQRERENLRQEIEKFQKQAL 1792
Query: 702 TVSSKIELNR-----------------KLIQDQQEQIQHLKSTTNELKSEKLQISTNLQR 744
S++I+ ++ K+++ + ++Q L+ N KS L+ T +++
Sbjct: 1793 EASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKST-LEAETRVKQ 1851
Query: 745 RQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDK 804
R + E+Q ++ ++ K Q S E + K + E+E+ +KN+ +
Sbjct: 1852 RLECEKQQIQ---------NDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERL 1902
Query: 805 LNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQ--------LSECEKHKE 856
+IK + ++D Q + + + + E++K+ + +ECE +
Sbjct: 1903 QAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVD 1962
Query: 857 KINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEE 897
+R+ + ++ E L D TL K + K VEE
Sbjct: 1963 TSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEE 2003
Score = 39.7 bits (91), Expect = 0.017
Identities = 143/799 (17%), Positives = 293/799 (36%), Gaps = 116/799 (14%)
Query: 88 ITSKEAQLTSSKEIVKS---YENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQME 144
+ S E + S + I S Y +LD +K L+E + +N +KA R +
Sbjct: 211 LASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERMDHLR 270
Query: 145 KDNSELEEKMEKVFQGTDEQLNDLYHN---HQRTVREKERKLVDCHRELEKLNKESRLLN 201
+ + ++ ++ D + +L ++ + +K+ +LE KE L
Sbjct: 271 QLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLK 330
Query: 202 QEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLV 261
QE +L++ Q + + + + ++ + S I + +++ E + +
Sbjct: 331 QESDQLVLNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHLKENAA--------YFQFF 382
Query: 262 RERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNV 321
E Q EA L + +K DK L ++E E L K++ ++
Sbjct: 383 EEAQSTEAYLKG-LQDSIRKKYPC---------DKNMPLQHLLEQIKE-LEKEREKILEY 431
Query: 322 KYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRK 381
K ++Q L S +I++L +N + + K ++ + + + K
Sbjct: 432 KRQVQNLVNKSKKIVQL-------------KPRNPDYRSNKPIILRALCDYKQDQKIVHK 478
Query: 382 LDQ-----EMEQLNHHTTTRTQMEMLTKD--------KADKDEQIRKIKSRHSDELTSLL 428
D+ E+ + T ++ML + KI+ + L
Sbjct: 479 GDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWN 538
Query: 429 GYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYED 488
+ N K L W H +I + R K + + K + EL +E +S
Sbjct: 539 QLYINMKSLVSW-HYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGS 597
Query: 489 KLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDE---NQSCCPV- 544
++F + D +++ + + K L Y Q T T E + +C V
Sbjct: 598 EMFG-------DDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVN 650
Query: 545 CQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLK 604
+V +T E + + + +L+ +++ E + K L L S
Sbjct: 651 HNKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKN------LPLADQGSS----- 699
Query: 605 EKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELK 664
I N+L++V D Q + + + + +L E K C + FQ +L+
Sbjct: 700 -HHITVKINELKSVQNDSQAIAEVLNQLKDMLANFRGSE---KYCYLQNEVFGLFQ-KLE 754
Query: 665 DVE-------RKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQ 717
++ + A LQ I + +V + + ++ + K+E R
Sbjct: 755 NINGVTDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRC----- 809
Query: 718 QEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLE 777
++ +K+ N KS + T LQ+ QQ+ QT +Q +
Sbjct: 810 --GLKKIKNDLNLKKSLLATMKTELQKAQQIHSQT-----------------SQQYPLYD 850
Query: 778 TTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIE---NYIQDGK---D 831
L KF ++ +L ++ +K +L D+++++K + Y + + ++ D K D
Sbjct: 851 LDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQD 910
Query: 832 DYKKQKETELNKVIAQLSE 850
+ K + N V+ L+E
Sbjct: 911 SLESMKFGDSNTVMRFLNE 929
Score = 37.7 bits (86), Expect = 0.065
Identities = 79/428 (18%), Positives = 168/428 (39%), Gaps = 52/428 (12%)
Query: 522 GATAVYSQFITQLTDENQS--CCPVCQRVFQTEAELQEVISD-----LQSKLRLAPDKLK 574
G + +Y +TD+N C Q + +QE++ + ++++L + P+ LK
Sbjct: 36 GTSRMYYSRRGVITDQNSDGYCQTGTMSRHQNQNTIQELLQNCSDCLMRAELIVQPE-LK 94
Query: 575 STESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQET 634
+ + + DE + I+D +E+ ++ + + +L+ +
Sbjct: 95 YGDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYK 154
Query: 635 LLGTIMPEEESAK-----VCLTDVTIMERFQMELKDVERKIAQQAAKLQ----GIDLDRT 685
+ S+K C + E + + + QQ A++ G+DL
Sbjct: 155 AISVPRVRRASSKGGGGYTCQSGSGWDEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASV 214
Query: 686 VQQVNQEKQ------EKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQIS 739
Q +N + + + +LD + + + + Q ++E LK++ + + L+
Sbjct: 215 EQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERM--DHLRQL 272
Query: 740 TNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNK 799
N+ + E + E + LY D ++ + + E F +L K+ NK
Sbjct: 273 QNIIQATSREIMWINDCEEEELLY----DWSDKNTNIAQKQEAFSIRMSQLEVKEKELNK 328
Query: 800 IAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKIN 859
+ Q+ + V N H IE Y+ + + I Q+++C K N
Sbjct: 329 LKQES----DQLVLNQHPASDKIEAYMDTLQTQWSW---------ILQITKCIDVHLKEN 375
Query: 860 EDMRLMRQDIDTQKIQERWLQD----------NLTLRKRNEELKEVEEERKQHLKEMGQM 909
++ + + + LQD N+ L+ E++KE+E+ER++ L+ Q+
Sbjct: 376 AAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKEREKILEYKRQV 435
Query: 910 QVLQMKSE 917
Q L KS+
Sbjct: 436 QNLVNKSK 443
Score = 37.4 bits (85), Expect = 0.085
Identities = 74/395 (18%), Positives = 158/395 (40%), Gaps = 53/395 (13%)
Query: 605 EKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELK 664
+ E+ L KL+N+N N + LL I+ E+ KV +T E ++L
Sbjct: 743 QNEVFGLFQKLENINGVTDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLD 802
Query: 665 DVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHL 724
VE A + ++++ + K+ L T+ ++++ +++ +Q
Sbjct: 803 KVE---AYRCG----------LKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLY 849
Query: 725 KSTTNELKSEKLQISTNLQR-RQQLEEQTVELSTEVQSL--YRE--------IKDAKEQV 773
+ + Q++ QR +Q++ + +L +++ L YR+ + DAK +
Sbjct: 850 DLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQ 909
Query: 774 SPLET-------TLEKFQQEKE----ELINKKNTS---NKIAQDKLNDIKEKVKNIHGYM 819
LE+ T+ +F E++ E+ K++ S KIA+ N IK+ + Y
Sbjct: 910 DSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYT 969
Query: 820 KDIENYIQ--------DGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDT 871
+E + Q+ +++ +L + +M +D+
Sbjct: 970 SGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKL 1029
Query: 872 QKIQERWLQDNLTL-RKRNEE----LKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENID 926
+ + L++ L L R N E K +++ +++ E Q + E K + +D
Sbjct: 1030 KNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELD 1089
Query: 927 --NIKRNHNLALGRQKGYEEEIIHFKKELREPQFR 959
+ K+N + G+ K E+I E+ + + R
Sbjct: 1090 GKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRR 1124
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 130 bits (327), Expect = 7e-30
Identities = 184/915 (20%), Positives = 391/915 (42%), Gaps = 116/915 (12%)
Query: 31 KALKQKFDEIFSATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITS 90
K+LK D + K L R + + + E + EL K+ + A E
Sbjct: 1409 KSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVE------- 1461
Query: 91 KEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSEL 150
+ T +K + E++ + L+ R +E NL +K D ++++L + K +E+ +
Sbjct: 1462 ---KFTDAKRSLLQTESDAEELERRAQETAVNL---VKADQQLRSLQADAKDLEQHKIKQ 1515
Query: 151 EE---KMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSEL 207
EE ++ K+ D L ++ E ++ D E+ + N++ L ++SE+
Sbjct: 1516 EEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDI--EMAERNEDHHLQVLKESEV 1573
Query: 208 LVEQGRLQLQA---------------DRHQEHIRARDSLIQSLATQLELDGFERGPFSER 252
L++ R +L+ DR H + L+Q Q + D E E
Sbjct: 1574 LLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGET 1633
Query: 253 QIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEIL- 311
++ +RE L+ + + ++ QI E + + T + + IE + E L
Sbjct: 1634 EVTEKCNHIRE--------VKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQ 1685
Query: 312 ------SKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSK-AEKNSNVETLKME 364
SK + ELKN+ ++ QLE + L+L + +E E ++ A +E ++
Sbjct: 1686 VVLRQMSKHKTELKNI-LDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQ 1744
Query: 365 VISLQNEKADLDRTLRKLDQEMEQLNHHTTT----RTQMEMLTKDKADKDEQIRKIKSRH 420
IS Q +K +++ + L+++ ++ T ++ +E L+K+K D E+ + +
Sbjct: 1745 QIS-QQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKL 1803
Query: 421 SDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKE 480
+ L N K + L + + + L +LN++ S + + + +L+ K
Sbjct: 1804 AQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKR 1863
Query: 481 EQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQS 540
E ++S +++L +V + L+ K+++ ++K + +L + I++ + +
Sbjct: 1864 EAVNSLQEELANV------QDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFED 1917
Query: 541 CCPVCQ------RVFQTEAE---------------LQEVISDLQSKLRLAPDKLKSTESE 579
C + +V Q E E LQ+ +SKL + LK + +
Sbjct: 1918 CQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQ 1977
Query: 580 LKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLL--- 636
L+K+ + L V + + + + + E +++ + + + K + E+E L
Sbjct: 1978 LEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEK 2037
Query: 637 -GTIMPEEESAKVCLTDVTIME-RFQMELKDVERKIA--QQAAKLQGIDLDRTVQQVNQE 692
G ++ ++ A D +++ +F E K E+++A ++A K+Q L++ + + QE
Sbjct: 2038 SGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQE 2097
Query: 693 KQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQT 752
Q ++ T IEL + QD E+ + L N+++ E ++ + ++ LE +
Sbjct: 2098 NSCIQKEMAT----IEL---VAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQ 2150
Query: 753 VELSTEVQSLYREIKD------------AKEQVSPLETTLEKFQQEKEELINKKN----T 796
+E+S +++L E+KD E + LE LE+ + + EL + K T
Sbjct: 2151 MEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFT 2210
Query: 797 SNK-IAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHK 855
N+ ++KLN + + + H + + ++ +D K Q ++K Q K K
Sbjct: 2211 MNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSK---QAEVLIKGK 2267
Query: 856 EKINEDMRLMRQDID 870
+ + +R+ +D
Sbjct: 2268 RQTEGTLHSLRRQVD 2282
Score = 119 bits (299), Expect = 1e-26
Identities = 175/910 (19%), Positives = 394/910 (43%), Gaps = 107/910 (11%)
Query: 122 NLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKER 181
N+ + L+NE+ L+ + ++ E E M + +++++ +L+HN ++EK
Sbjct: 1314 NVPEHHNLENEVSRLEDIMQHLKSKKRE-ERWMRASKRQSEKEMEELHHNIDDLLQEK-- 1370
Query: 182 KLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLEL 241
K ++C E+E+L++ + Q+K + D ++SL T+LE+
Sbjct: 1371 KSLEC--EVEELHRTVQKRQQQKDFI---------------------DGNVESLMTELEI 1407
Query: 242 DGFERGPFSERQIKNFHKLVRE---------RQEGEAKTANQLMNDFAEKETLKQKQ--- 289
E+ +K+ +V E ++ E + A++L+ + AE E K+
Sbjct: 1408 ---------EKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAE-AESELSCTKEKTK 1457
Query: 290 --IDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAER 347
+++ D K L + E+ + Q N+ QQL +L+Q IK E
Sbjct: 1458 NAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEE 1517
Query: 348 ELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQL----NHHTTTRTQMEMLT 403
L + K + + +S + EK L L+KL +++E +HH + E+L
Sbjct: 1518 ILKEINKIVAAKDSDFQCLSKKKEK--LTEELQKLQKDIEMAERNEDHHLQVLKESEVLL 1575
Query: 404 KDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELA 463
+ K + E+++ + E+ L +KK+ L + +L +
Sbjct: 1576 QAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGE--T 1633
Query: 464 SSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGA 523
+ NHI E+K E+LS + +L + ++ L +K+EIEK + ++
Sbjct: 1634 EVTEKCNHI-REVKSLLEELSFQKGELNVQISER--KTQLTLIKQEIEKEEENLQVVLRQ 1690
Query: 524 TAVYSQFITQLTD----ENQSCCPVCQRVFQTEAELQEV-ISDLQSKLRLAPDKLKSTES 578
+ + + + D EN + + Q +EL++ ++ L+ KL
Sbjct: 1691 MSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKL------------ 1738
Query: 579 ELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPEL---RNKLQNVNRDIQRLKNDIEEQETL 635
EL+ ++ + G + ++ +++ ++EI + LQ+ + + K D++E+ +
Sbjct: 1739 ELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDI 1798
Query: 636 LGTIMPEEESAKVCLTDVTIMERFQMELKDVE-RKIAQQAAKL--QGIDLDRTVQQVNQE 692
+ + + + + ME+ +E ++ RK+ Q+ +L + L + + Q+
Sbjct: 1799 WEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQ 1858
Query: 693 KQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNL----QRRQQL 748
QEK+ ++++ ++ + + ++ + H + L SE+ ++ ++ R +
Sbjct: 1859 LQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDC 1918
Query: 749 EEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQD----- 803
+++ ++Q L EI++ K ++ E ++ Q+E+E +K TS ++
Sbjct: 1919 QKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQL 1978
Query: 804 --KLNDIKEKVKNIHGYMKDIENYIQDGKDDYK--KQKETELNKVIAQLSECEKHKEKIN 859
+L D K K+ + + E ++ +++ + + E L++ QLSE E+ + +
Sbjct: 1979 EKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKS 2038
Query: 860 EDMRLMRQDIDTQKIQERWLQDN-LTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEH 918
++ ++++ D+ + L++ LT RK+ E+ +E + + + +L+ K E+
Sbjct: 2039 GELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQEN 2098
Query: 919 QKLEENIDNI----KRNHNLALGRQKGYEE---EIIHFKKELREPQFRDAEEKYREMMIV 971
+++ + I + NH A K + E KK++ +D E + E+
Sbjct: 2099 SCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQ--KDLERRQMEISDA 2156
Query: 972 MRTTELVNKD 981
MRT + KD
Sbjct: 2157 MRTLKSEVKD 2166
Score = 118 bits (296), Expect = 3e-26
Identities = 193/1003 (19%), Positives = 424/1003 (42%), Gaps = 155/1003 (15%)
Query: 112 LKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQ---GTDEQLNDL 168
L+N + +E + + E + + + K+Q EK+ EL ++ + Q + ++ +L
Sbjct: 1321 LENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEEL 1380
Query: 169 YHNHQRTVREKERKLVDCHRE--LEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIR 226
+ Q+ R++++ +D + E + +L E L + E +++ E ++ + + +R
Sbjct: 1381 HRTVQK--RQQQKDFIDGNVESLMTELEIEKSLKHHE--DIVDEIECIEKTLLKRRSELR 1436
Query: 227 ARDSLIQSLATQLEL------DGFERGPFSERQI----KNFHKLVRERQE---GEAKTAN 273
D L+ ++L + E+ ++R + + +L R QE K
Sbjct: 1437 EADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQ 1496
Query: 274 QLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKS---EILSKKQ----NELKNVKYELQ 326
QL + A+ + L+Q +I + K + +I+ K + LSKK+ EL+ ++ +++
Sbjct: 1497 QLRSLQADAKDLEQHKIKQEEILKE-INKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIE 1555
Query: 327 QLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEM 386
E + D L+ + E E+ K + +E LK +V S Q E A LDR L +E+
Sbjct: 1556 MAERNEDHHLQ-----VLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEEL 1610
Query: 387 --------------------------EQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRH 420
E+ NH ++ +E L+ K + + QI S
Sbjct: 1611 HLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQI----SER 1666
Query: 421 SDELTSLLGYFPNKKQ-LEDWLHSKSK---EINQTRDRLAKLNKELASSEQNKNHINNEL 476
+LT + +++ L+ L SK E+ D L N EL + + +EL
Sbjct: 1667 KTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSEL 1726
Query: 477 KRKEEQLSSYEDKLFDVCG-SQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLT 535
++ + + + +L ++ SQ + +++ K+ +E+ ++ + + + L+
Sbjct: 1727 EKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLS 1786
Query: 536 DENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEM----L 591
E + C + A+ + V++ + ++ L+ E ++K ++ D++ L
Sbjct: 1787 KEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKL 1846
Query: 592 GL---VPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDI----EEQETLLG--TIMPE 642
L + Q + K + + L+ +L NV + K D+ + Q+ LL T + +
Sbjct: 1847 SLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQK 1906
Query: 643 ---------EESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQ------ 687
E+ K T ++ Q E+++ + K+ QQ Q + +R +
Sbjct: 1907 DISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLET 1966
Query: 688 ----------QVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQ 737
Q+ +E +++ KLD V SK+ + ++ QE+ + +S L K Q
Sbjct: 1967 SKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQ 2026
Query: 738 ISTNLQRRQQLEEQTVE---LSTEVQSL-----------YREIKDAKEQVSPLETTLEKF 783
+S +R QQL E++ E L E S+ E K A++QV+ L+ L+
Sbjct: 2027 LS---EREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQ 2083
Query: 784 QQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNK 843
+ + E+ + ++ N Q ++ I+ ++ H + + + + +Y TEL K
Sbjct: 2084 RSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEY-----TELKK 2138
Query: 844 VIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHL 903
+A + E+ + +I++ MR ++ ++ + +L+ N+ L E+ + + L
Sbjct: 2139 QMANQKDLERRQMEISDAMRTLKSEVKD--------EIRTSLKNLNQFLPELPADLEAIL 2190
Query: 904 KEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEI----IHFKKELREPQFR 959
+ ++ LE ++++K N + + +EE++ +H E +
Sbjct: 2191 E------------RNENLEGELESLKENLPFTM-NEGPFEEKLNFSQVHIMDEHWRGEAL 2237
Query: 960 DAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKME 1002
+ ++RE + + ++K ++ K Q HS++ +
Sbjct: 2238 REKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQ 2280
Score = 104 bits (260), Expect = 4e-22
Identities = 176/888 (19%), Positives = 365/888 (41%), Gaps = 151/888 (17%)
Query: 253 QIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILS 312
Q FH E EG+ T +E ++ ++E+ + L + + E+ S
Sbjct: 238 QFTIFHLRSLESLEGQPVTTQD------RQEAFERFSLEEVERLERDLEKKMIETEELKS 291
Query: 313 KKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQN-- 370
K+ L+ +K + ++ L+ + L K E K++ N+ E LK + I L
Sbjct: 292 KQTRFLEEIKNQ-----DKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRAC 346
Query: 371 -EKADLDRTLR--KLDQEMEQLNHHTTTRTQME------------------MLTKDKADK 409
++ +L++ L K+D + E LN++ + +++ T+
Sbjct: 347 QKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIID 406
Query: 410 DEQIRKIKSRHSDEL-----TSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELAS 464
Q +IK DE +L G+ P QLED K K+I+ + RL++L+ E+
Sbjct: 407 SAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLED----KEKKISAAQTRLSELHDEIEK 462
Query: 465 SEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGAT 524
+EQ E K+ EE + +++K S+ AG
Sbjct: 463 AEQQILRATEEFKQLEEAI-------------------------QLKKISE-----AGKD 492
Query: 525 AVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKE 584
+Y Q +L N+ + Q E ++++ ++ K + D L+ L K+
Sbjct: 493 LLYKQLSGRLQLVNK----LRQEALDLELQMEKQKQEIAGKQKEIKD-LQIAIDSLDSKD 547
Query: 585 KRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLL--GTIMPE 642
+ M ++ +D+ K+ +L ++L + I + +I++ E L G I
Sbjct: 548 PKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAAN 607
Query: 643 EESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDT 702
E K ++ ++ + +K + + KL+ D T+ Q E ++++ +L+
Sbjct: 608 EALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLR--DEKETLLQRLTEVEQERDQLEI 665
Query: 703 VSSKIELNRK-------LIQDQQEQIQHLKSTTNELKSEKLQISTNL--------QRRQQ 747
V+ E RK +Q+Q E L+ T +L + + ++ L Q +++
Sbjct: 666 VAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEE 725
Query: 748 LEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEK--FQQEKEELINKKNTSNKIAQDKL 805
LE+ T E +L E++ ++ L+ L K F +EKE+ ++ + K QD
Sbjct: 726 LEKVTRLTQLEQSALQAELEKERQ---ALKNALGKAQFSEEKEQENSELHAKLKHLQDDN 782
Query: 806 NDIKEKVKNIHGYMKDIENYIQDG---KDDYKKQKETELNKVIAQLSECEKH-------- 854
N +K+++K+ ++ N++ DG ++ + + K+ E H
Sbjct: 783 NLLKQQLKDFQNHL----NHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGK 838
Query: 855 -----KEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKR-----NEELKE----VEEERK 900
+++ +E + + + D +++ER LQ+ + L++ EE ++ E R
Sbjct: 839 SLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARM 898
Query: 901 QHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELRE----P 956
K + ++ QM++E L+EN+ +++ L + + +EE +LRE
Sbjct: 899 NFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKK 958
Query: 957 QFRDA----------EEKYREMMIVMRTTELVNKDLDI---YYKTLDQAIMKFHSMKMEE 1003
+ DA +E + V + +L +L I K+L +MK + + EE
Sbjct: 959 KLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEE 1018
Query: 1004 INKIIRDLWRSTYRGQDIEYIEIRSDADENVSASDKRRNYNYRVVMLK 1051
+ + R ++ +D+ E + +N+ +++ +R+ M K
Sbjct: 1019 LQEAERFSRKAAQAARDLTRAEAEIELLQNLL---RQKGEQFRLEMEK 1063
Score = 103 bits (257), Expect = 1e-21
Identities = 192/940 (20%), Positives = 401/940 (42%), Gaps = 134/940 (14%)
Query: 48 KALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYEN 107
K +ET +++ Q + ++E + + K K KE+A + ++ L + E++K
Sbjct: 282 KMIET-EELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTI 340
Query: 108 ELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLND 167
EL + E+E L+ +D++ + + SE E + + DE
Sbjct: 341 ELTRACQKQYELEQELA--------FYKIDAKFEPLNYYPSEYAE----IDKAPDESPYI 388
Query: 168 LYHNHQRTVREKERKLVDCHR--ELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHI 225
++R + E ++D + +++K+ + +L N + L L Q + ++ I
Sbjct: 389 GKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMN--LRGHTPLDTQLEDKEKKI 446
Query: 226 RARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEG-EAKTANQLMNDFAEKET 284
A + + L ++E +E+QI + ++ +E + K ++ D K+
Sbjct: 447 SAAQTRLSELHDEIEK--------AEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQL 498
Query: 285 LKQKQ-IDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELI 343
+ Q ++++R + L +E + + ++ KQ E+K+++ + L+ + +
Sbjct: 499 SGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHM----- 553
Query: 344 KAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLT 403
KA+K+ + L + Q ++ LD L ++ +E E++ T+ ++
Sbjct: 554 -------KAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAA 606
Query: 404 KDKADKD---------EQIRKIKSRHS----------DELTSLLGYFPNKKQLEDWLHSK 444
+ KD E + IK + + DE +LL +Q D L
Sbjct: 607 NEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIV 666
Query: 445 SKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLD 504
+ + R LA EL S+ Q ++ +N L++ + LS+YE +L +D E++
Sbjct: 667 AMDAENMRKELA----ELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEAN-- 720
Query: 505 RLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQS 564
+LKEE+EK ++ + A +L E Q+ + +E + QE S+L +
Sbjct: 721 QLKEELEKVTRLTQLEQSALQA------ELEKERQALKNALGKAQFSEEKEQEN-SELHA 773
Query: 565 KLRLAPDKLKSTESELKKKEKRRDEML-GLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQ 623
KL+ D + +LK + + ++ GLV + + ELR KL+ ++
Sbjct: 774 KLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAA-----RVDELRRKLKLGTGEM- 827
Query: 624 RLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLD 683
+I +LG + + + + + ER + +++ ERK+ ++ A Q +
Sbjct: 828 ----NIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVR--ERKLQEEMALQQ----E 877
Query: 684 RTVQQVNQEKQEKQHKLDT-VSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNL 742
+ + +Q + L+ ++ + IQ + +I +L+ + E++Q T+L
Sbjct: 878 KLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSM--EEIQGLTDL 935
Query: 743 QRRQQLEEQTVELSTEVQSLYRE--IKDAK--EQVSPLETTLEKFQQEKEELINKKNTSN 798
Q Q+ +E+ + +++ L ++ ++DAK EQV L+ L+K ++ TS+
Sbjct: 936 QL-QEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVA-------TSD 987
Query: 799 KIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKI 858
K+A +L K+++K++HG + I Q+ E +L E E+ K
Sbjct: 988 KLATAELTIAKDQLKSLHGTVMKI------------NQERAE------ELQEAERFSRKA 1029
Query: 859 NEDMR-LMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSE 917
+ R L R + + + +Q LR++ E+ + E K + QVL+++
Sbjct: 1030 AQAARDLTRAEAEIELLQN-------LLRQKGEQFR--LEMEKTGVGTGANSQVLEIEKL 1080
Query: 918 HQKLEENIDNIKRNHN---LALGRQKGYEEEIIHFKKELR 954
++ +E I R N L KG E ++ ELR
Sbjct: 1081 NETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELR 1120
Score = 66.2 bits (160), Expect = 2e-10
Identities = 80/413 (19%), Positives = 178/413 (43%), Gaps = 54/413 (13%)
Query: 58 QTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDP-LKNRL 116
+ + K+K Q E+ + + KE+ S+E++L +SK +K +++L+ L ++
Sbjct: 1935 EIEENKLKLVQQEMMFQRLQKERE--------SEESKLETSKVTLKEQQHQLEKELTDQK 1986
Query: 117 KEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTV 176
+++ LSK++ + ++ L ++ E +EK T QL++ ++ +
Sbjct: 1987 SKLDQVLSKVLAAEERVRTLQEEERWCES--------LEKTLSQTKRQLSE----REQQL 2034
Query: 177 REKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLA 236
EK +L+ +E + + + LL +++ L E+ + + Q +E ++ + S ++
Sbjct: 2035 VEKSGELLALQKEADSMRADFSLL---RNQFLTERKKAEKQVASLKEALKIQRSQLEKNL 2091
Query: 237 TQLELDGFERGPFSERQIKNFHKLVRERQEGEA---KTANQLMNDFAEKETLKQKQIDEI 293
L+ + ++++ + ++ E K NQ+ ++ E + Q D
Sbjct: 2092 ----LEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLE 2147
Query: 294 RDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAE 353
R + + LKSE+ + + LKN+ L +L + ILE ++ L
Sbjct: 2148 RRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENL----------- 2196
Query: 354 KNSNVETLKMEVISLQNEKADLDRTLRKLD-QEMEQLNHHTTTRTQMEMLTKDKADKDEQ 412
+E+LK + NE + KL+ ++ ++ H E L + Q
Sbjct: 2197 -EGELESLKENLPFTMNEGPFEE----KLNFSQVHIMDEHWRGEALREKLRHREDRLKAQ 2251
Query: 413 IRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASS 465
+R S+ ++ L K+Q E LHS ++++ + + + + ASS
Sbjct: 2252 LRHCMSKQAEVLIK------GKRQTEGTLHSLRRQVDALGELVTSTSADSASS 2298
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 129 bits (323), Expect = 2e-29
Identities = 185/926 (19%), Positives = 403/926 (43%), Gaps = 104/926 (11%)
Query: 78 KEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDN-----E 132
+E+ + D + + AQ S ++ E+EL ++ ++E+ L ++ +
Sbjct: 135 REEEFGVDDSYSEQGAQ--DSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQ 192
Query: 133 IKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEK 192
++ ++ KQ + ++L +++ + DE + + + E+ +KL + ++
Sbjct: 193 LQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLE-----LTEQSQKL---QIQFQQ 244
Query: 193 LNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSER 252
L L N S + + + Q HQ+ + +D L++ + E D + F +
Sbjct: 245 LQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKE-DFTMQISFLQE 303
Query: 253 QIKNFHKLVRERQEGEAKTANQLMNDFAEKETL----------KQKQIDEIRDKKTGLGR 302
+IK + E + K N + EKET+ ++K+ E++DK T +
Sbjct: 304 KIKVYE------MEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADK 357
Query: 303 II-ELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETL 361
++ EL+ +I+ K Q E+KN+K EL + + E ++L+ EL K N +
Sbjct: 358 LLGELQEQIVQKNQ-EIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQK----RNHKDS 412
Query: 362 KMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHS 421
+ E +Q + + R L +L E++++ + + E++ + A Q+ ++K+RH
Sbjct: 413 QFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMA----QMEEMKTRHK 468
Query: 422 DELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEE 481
E+ + L + N ED + + IN+ LN +L + K + EL E
Sbjct: 469 GEMENALRSYSNITVNEDQIKLMNVAINE-------LNIKLQDTNSQKEKLKEELGLILE 521
Query: 482 QLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSC 541
+ + + +L +D +L +E+I+++ + A + ++ + D
Sbjct: 522 EKCALQRQL------EDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEI 575
Query: 542 CPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSII 601
+ + E + + +++ + KL + + + + + ++ E L R ++
Sbjct: 576 VSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERL-----RTQLL 630
Query: 602 DLKEKEIPELRNKLQNVNR-DIQRLKNDI----EEQETLLGTIMPEEESAKVCLTDVTIM 656
E+E+ +L+ L+ +R +I++LK+++ ++Q L M ++ D I
Sbjct: 631 FSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLIT 690
Query: 657 ERFQM-----ELKDVERKIAQQAAK---LQGIDLDRTVQQVNQEKQEK---QHKLDTVSS 705
++ Q+ +LKD+++ + ++ LQ +L + ++ + QE++EK + ++ +
Sbjct: 691 KQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQL 750
Query: 706 KIELNRKLIQ----DQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQS 761
K EL K ++ D QE+ L++ + LK EK + L+ +S E +
Sbjct: 751 KTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIH-------TPVSQEERL 803
Query: 762 LYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIH-GYMK 820
++ + +K + S E +E +E E+L + N+ + + N KN Y +
Sbjct: 804 IFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQE 863
Query: 821 DIENY-----IQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDI------ 869
E Y ++D +D K ++E E + L+E E H ++IN M+ +
Sbjct: 864 LQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNE-ELHLQRINPTTVKMKSSVFDEDKT 922
Query: 870 ---DTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENID 926
+T ++ E +D L ++ E K + E Q L ++ + Q+ Q E L E +
Sbjct: 923 FVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSE-QLKQKHGEISFLNEEVK 981
Query: 927 NIKRNHNLALGRQKGYEEEIIHFKKE 952
++K+ R + E I H + E
Sbjct: 982 SLKQEKEQVSLRCRELEIIINHNRAE 1007
Score = 124 bits (312), Expect = 4e-28
Identities = 202/960 (21%), Positives = 419/960 (43%), Gaps = 133/960 (13%)
Query: 27 LSEGKALKQKFDEIFSATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRD 86
+++ + +++ F + AT +K E LR+ + + ++ +EL + + D
Sbjct: 1873 VTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYA---D 1929
Query: 87 QITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMK----LDNEIKALDSRKKQ 142
+ T E Q+ +I+ E EL NRL+E+E +I + L + +A+ +
Sbjct: 1930 EKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGP 1989
Query: 143 ME-----------KDNSELEEKMEKVFQGTDEQLNDLYHNHQRTV-------REKERKLV 184
+E K+ E++ + EKV +Q+ L + + V +EK +L+
Sbjct: 1990 VEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELM 2049
Query: 185 DCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLE-LDG 243
D ++ + L K+ + + E +++ H+ + ++ IQ L QL+ +
Sbjct: 2050 DLRQQNQALEKQLEKMRKFLDEQAIDR--------EHERDVFQQE--IQKLEQQLKVVPR 2099
Query: 244 FERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLG-R 302
F+ P SE Q + +L +E K + L++ KE L Q+ I E ++ L R
Sbjct: 2100 FQ--PISEHQTREVEQLANHLKEKTDKCSELLLS----KEQL-QRDIQERNEEIEKLEFR 2152
Query: 303 IIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQEL-IKAERELSKAEKNSNVETL 361
+ EL+ +L K E ++ G+ + EL E+ ++AER+ + K + L
Sbjct: 2153 VRELEQALLVSADT---FQKVEDRKHFGAVEAKPELSLEVQLQAERD-AIDRKEKEITNL 2208
Query: 362 KMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQ------IRK 415
+ ++ + E + + +++L ++E +TTR Q E+ ++K KD+ I++
Sbjct: 2209 EEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQ-ELEQENKLFKDDMEKLGLAIKE 2267
Query: 416 IKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQN-----KN 470
+ + + L G F + K EI+Q +++ KL ++L + N KN
Sbjct: 2268 SDAMSTQDQHVLFGKF------AQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKN 2321
Query: 471 HINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQF 530
+ +L+ + E L S ++ C ++ E ++++L E IEK ++ A + T++ +
Sbjct: 2322 ELIRDLETQIECLMSDQE-----CVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAH- 2375
Query: 531 ITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEM 590
L++E S V + L++ + ++ + LK T K + E+
Sbjct: 2376 --SLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNF---KMNQLTQEL 2430
Query: 591 LGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCL 650
L R+S+ K + IPE +VN I L D E E +L E A L
Sbjct: 2431 FSLKRERESV--EKIQSIPE-----NSVNVAIDHLSKDKPELEVVL------TEDALKSL 2477
Query: 651 TDVTIMERFQMELK----DVERKIAQQAAKLQGIDLDRT--VQQVNQEKQEKQHKLDTVS 704
+ T + F+ K ++E ++ Q + + DL+ T +Q+ +++ Q + + +
Sbjct: 2478 ENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQ 2537
Query: 705 SKIELNRKLIQDQ-------QEQIQHLKSTTNELKSEKLQIS----TNLQRRQQLEEQTV 753
KI +K+++++ Q Q++ ++ + + S TN+Q QL E
Sbjct: 2538 KKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLRED-- 2595
Query: 754 ELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVK 813
EL +++ +L I + + QV + T+L ++E+ E+ K ++ EK K
Sbjct: 2596 ELGSDISALTLRISELESQVVEMHTSL-ILEKEQVEIAEK-------------NVLEKEK 2641
Query: 814 NIHGYMKDIENYIQDGKDDYKKQ--KETELNKVIAQLSECEKHKEKINEDMRLMRQDIDT 871
+ K +E + ++ KK+ ++ E+ K +L + NE L + + T
Sbjct: 2642 KLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVAT 2701
Query: 872 Q------KIQERWLQDNLTLRKRN-EELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEEN 924
+ K + LQ+ L +++ N L++ + + HL E + + K + +++E+
Sbjct: 2702 KAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQES 2761
Score = 122 bits (306), Expect = 2e-27
Identities = 202/1044 (19%), Positives = 446/1044 (42%), Gaps = 137/1044 (13%)
Query: 90 SKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSE 149
++E L S + + E L+ + ++EH +K+ + E+ R+KQ ++ +
Sbjct: 1839 NEELMLNISSRLQAAVEKLLEAISETSSQLEH--AKVTQ--TELMRESFRQKQEATESLK 1894
Query: 150 LEEKMEKVFQGTDEQLNDLYHNHQRTVRE--KERKLVDCHRELEKL-----NKESRLLNQ 202
+E++ E+L++ ++ E K ++D + + + L +++ ++++
Sbjct: 1895 CQEELR-------ERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDR 1947
Query: 203 EKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVR 262
+ ELL RLQ + + Q+ I+ L L+ Q E E GP ++ ++ KL++
Sbjct: 1948 LEQELLCASNRLQ-ELEAEQQQIQEEREL---LSRQKEAMKAEAGPVEQQLLQETEKLMK 2003
Query: 263 ERQEGEAKTANQLMNDFAEKETLKQKQIDEIR-DKKTGLGRIIELKSEILSKKQNELKNV 321
E+ E + + A ++ +D QKQ+ + D + + R IEL+ E K EL ++
Sbjct: 2004 EKLEVQCQ-AEKVRDDL-------QKQVKALEIDVEEQVSRFIELEQE----KNTELMDL 2051
Query: 322 KYELQQLEGSSDRILE-LDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLR 380
+ + Q LE +++ + LD++ I E E ++ ++ L+ ++ + + + R
Sbjct: 2052 RQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQE--IQKLEQQLKVVPRFQPISEHQTR 2109
Query: 381 KLDQEMEQLNHHTTTRTQM----EMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQ 436
+++Q L T +++ E L +D +++E+I K++ R + +LL ++
Sbjct: 2110 EVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQK 2169
Query: 437 LEDWLH----------SKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSY 486
+ED H S ++ RD + + KE+ + E+ EL+ K E++
Sbjct: 2170 VEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQL 2229
Query: 487 E-----DKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSC 541
K Q+ E + K+++EK A+ D++
Sbjct: 2230 HMQLEIQKKESTTRLQELEQENKLFKDDMEKLG---------LAIKESDAMSTQDQHVLF 2280
Query: 542 CPVCQRVFQTEAE---LQEVISDLQSKLRLAPD-KLKSTESELKKKEKRRDEMLGLVPMR 597
Q + + E E L E ++ LQ +L++ D K+ ++EL + + + E L + +
Sbjct: 2281 GKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECL--MSDQ 2338
Query: 598 QSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIME 657
+ + +E+EI +L ++ + +++ +I ++ ++ + EE + DV I E
Sbjct: 2339 ECVKRNREEEIEQLNEVIEKLQQELA----NIGQKTSMNAHSLSEEADSLKHQLDVVIAE 2394
Query: 658 RF----QMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQ--HKLDTV-------- 703
+ Q+E + E + K +++ Q++ K+E++ K+ ++
Sbjct: 2395 KLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVA 2454
Query: 704 -----SSKIELNRKLIQDQQEQIQ---HLKSTTNELKSEKLQISTNLQRRQQLEEQTVEL 755
K EL L +D + ++ + KS K + + T L QLE
Sbjct: 2455 IDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLL---QLESTVSAK 2511
Query: 756 STEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNI 815
E+ Y++IKD +EQ L+K ++++ +K + ++Q +L ++E K
Sbjct: 2512 DLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAK-- 2569
Query: 816 HGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQ 875
+ QD + + + T + + QL E +++ D+ + I + Q
Sbjct: 2570 ---------FCQDNQTISSEPERTNIQN-LNQLRE-----DELGSDISALTLRISELESQ 2614
Query: 876 ERWLQDNLTLRKRNEELKE---VEEERK----QHLKEMGQMQVLQMKSEHQKLEENIDNI 928
+ +L L K E+ E +E+E+K Q L E + + Q + E ++ ++++ +
Sbjct: 2615 VVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKK--QREKEKKRSPQDVEVL 2672
Query: 929 KRNHNL-ALGRQKGYEEEIIHFKKE-----LREPQFRDAEEKYREMMIVMRTT-ELVNKD 981
K L + G+ E+ + E +++ EK +E ++V T + KD
Sbjct: 2673 KTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKD 2732
Query: 982 LDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQDIEYIE-IRSDADENVSASDKR 1040
L L +A K ++ E+ ++ + I+ + I S D + S
Sbjct: 2733 LSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSS- 2791
Query: 1041 RNYNYRVVMLKGDTALDMRGRCSA 1064
N ++++ ++++ CS+
Sbjct: 2792 -NQTPQILVKNAGIQINLQSECSS 2814
Score = 105 bits (262), Expect = 3e-22
Identities = 148/707 (20%), Positives = 306/707 (43%), Gaps = 121/707 (17%)
Query: 337 ELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTR 396
EL Q L+++ + E + E L + + S +A +++ L + + QL H T+
Sbjct: 1820 ELSQRLVRSG--FAGTEIDPENEELMLNISS--RLQAAVEKLLEAISETSSQLEHAKVTQ 1875
Query: 397 TQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLA 456
T E++ + K E +K + ++L + LH +S+ Q L+
Sbjct: 1876 T--ELMRESFRQKQEATESLKCQ---------------EELRERLHEESRAREQLAVELS 1918
Query: 457 KLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGS---QDFESDLDRLKEEIEKS 513
K + K +++ K + + E +L +C S Q+ E++ +++EE E
Sbjct: 1919 KAEGVIDGYADEKTLFERQIQEKTDIIDRLEQEL--LCASNRLQELEAEQQQIQEERELL 1976
Query: 514 SKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKL 573
S+Q+ + Q + Q T++ + + + + + ++V DLQ ++
Sbjct: 1977 SRQKEAMKAEAGPVEQQLLQETEK------LMKEKLEVQCQAEKVRDDLQKQV------- 2023
Query: 574 KSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQE 633
K+ E +++++ R + + Q K E+ +LR + Q + + +++++ ++EQ
Sbjct: 2024 KALEIDVEEQVSR------FIELEQE----KNTELMDLRQQNQALEKQLEKMRKFLDEQ- 2072
Query: 634 TLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRT--VQQVNQ 691
I E E + FQ E++ +E+++ + + Q I +T V+Q+
Sbjct: 2073 ----AIDREHER-----------DVFQQEIQKLEQQL-KVVPRFQPISEHQTREVEQLAN 2116
Query: 692 EKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLE-- 749
+EK K + E ++ IQ++ E+I+ L+ EL+ L + Q+ + +
Sbjct: 2117 HLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHF 2176
Query: 750 ---EQTVELSTEVQ---------SLYREIKDAKEQVSPLETTLEKFQQEKEEL-----IN 792
E ELS EVQ +EI + +EQ+ LE +E ++L I
Sbjct: 2177 GAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQ 2236
Query: 793 KKNTS---------NKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGK-DDYKKQKETELN 842
KK ++ NK+ +D + + +K M + ++ GK ++KE E++
Sbjct: 2237 KKESTTRLQELEQENKLFKDDMEKLGLAIKESDA-MSTQDQHVLFGKFAQIIQEKEVEID 2295
Query: 843 KVIAQLSECEKH-----KEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEE----LK 893
++ Q+++ ++ K+ E+ + +D++TQ E + D +++ EE L
Sbjct: 2296 QLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQ--IECLMSDQECVKRNREEEIEQLN 2353
Query: 894 EVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYE-------EEI 946
EV E+ +Q L +GQ + S L E D++K ++ + + E EE+
Sbjct: 2354 EVIEKLQQELANIGQKTSMNAHS----LSEEADSLKHQLDVVIAEKLALEQQVETANEEM 2409
Query: 947 IHFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAI 993
K L+E F+ + +E+ + R E V K I +++ AI
Sbjct: 2410 TFMKNVLKETNFK-MNQLTQELFSLKRERESVEKIQSIPENSVNVAI 2455
Score = 102 bits (253), Expect = 3e-21
Identities = 189/978 (19%), Positives = 406/978 (41%), Gaps = 114/978 (11%)
Query: 72 KYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDN 131
K L + +E+ + +I + + +LT+SK+ + E+ L ++E++ K + +
Sbjct: 357 KLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFET 416
Query: 132 EIKALDSRKKQMEKDNSELEEKMEKVF-QGTDEQLNDLYHNHQRTVRE-KERKLVDCHRE 189
+I + +++ ++ +L ++++++ Q + +L H + E K R +
Sbjct: 417 DI--VQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENA 474
Query: 190 LEKLNK------ESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDG 243
L + + +L+N +EL ++ Q ++ +E + +L QLE D
Sbjct: 475 LRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLE-DL 533
Query: 244 FERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRI 303
E FS QI+ + + E QE + A+ K + + D K +
Sbjct: 534 VEELSFSREQIQRARQTIAE-QESKLNEAH--------------KSLSTVEDLKAEIVSA 578
Query: 304 IELKSEILSKKQNELKNVKYELQQLEGSSDRIL---------ELD----QELIKAERELS 350
E + E+ K + E+ N K +L+ LE + +L EL+ Q L E ELS
Sbjct: 579 SESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELS 638
Query: 351 KAEKNSNVETLKMEVISLQNE-----KADLDRTLRKLDQEME--QLNHHTTTRTQMEMLT 403
K +++ +E ++ + L++ K +D ++ Q++E Q Q +++
Sbjct: 639 KLKEDLEIEH-RINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLIL 697
Query: 404 KDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLE-DWLHSKSKEINQTRDRLAKLNKEL 462
+ KD Q + S+ S+E+T + N+ Q E + L + KE + +L +
Sbjct: 698 EISKLKDLQQSLVNSK-SEEMTLQI----NELQKEIEILRQEEKEKGTLEQEVQELQLKT 752
Query: 463 ASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAG 522
E+ N+L+ K QL + L D + ++ D LK S ++R +
Sbjct: 753 ELLEKQMKEKENDLQEKFAQLEAENSILKD-----EKKTLEDMLKIHTPVSQEERLIFLD 807
Query: 523 A------TAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKST 576
+ +V+ + I L +EN+ C +L E I ++ A +
Sbjct: 808 SIKSKSKDSVWEKEIEILIEENEDLKQQC-------IQLNEEIEKQRNTFSFAEKNFEVN 860
Query: 577 ESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQ---------RLKN 627
EL ++E L+ ++ + D K K+ E ++KL+ +N ++ ++K+
Sbjct: 861 YQEL------QEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKS 914
Query: 628 DIEEQ------ETL-LGTIMPEEESAKVCLTDVTIMERFQM--ELKDVERKIAQQAAKLQ 678
+ ++ ETL +G ++ ++ + + +VT E+ ++ L D+ ++ Q+ ++
Sbjct: 915 SVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEIS 974
Query: 679 GIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNR-KLIQDQQEQIQHLKSTTNELKSEKLQ 737
L+ V+ + QEK++ + + I NR + +Q Q+ L + S +
Sbjct: 975 --FLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAE 1032
Query: 738 ISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTS 797
S + + EE + + +V + + +Q + L +E + + +
Sbjct: 1033 GSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSEN 1092
Query: 798 NKIAQDKLNDIKEKVKNIHGYMKD----IENYIQDGKDDYKKQKETELNKVIAQLSE--C 851
+K+ Q +LN +K + ++ M+ + D ++ E E +K + L E
Sbjct: 1093 DKL-QKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELI 1151
Query: 852 EKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKE----MG 907
+EKI E ++ + ++ T K QE + + K V EE L+ +G
Sbjct: 1152 FAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLG 1211
Query: 908 QMQVLQMKSE--HQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKY 965
+ +K E + E + D I N + L + Y E+ F++ + + EE
Sbjct: 1212 EYYTPALKCEVNAEDKENSGDYISENEDPEL---QDYRYEVQDFQENMHTLLNKVTEEYN 1268
Query: 966 REMMIVMRTTELVNKDLD 983
+ +++ R +++ + D
Sbjct: 1269 KLLVLQTRLSKIWGQQTD 1286
Score = 79.7 bits (195), Expect = 1e-14
Identities = 206/998 (20%), Positives = 428/998 (42%), Gaps = 157/998 (15%)
Query: 48 KALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYEN 107
K + L+++ + + Q++L+ +++Y K C+ +Q S E + T+ + + + E+
Sbjct: 2538 KKIVNLQKIVEEKVAAALVSQIQLEAVQEYA-KFCQ-DNQTISSEPERTNIQNLNQLRED 2595
Query: 108 EL----DPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDE 163
EL L R+ E+E S+++++ +L K+Q+E + EK +K+ +
Sbjct: 2596 ELGSDISALTLRISELE---SQVVEMHT---SLILEKEQVEIAEKNVLEKEKKLLE---- 2645
Query: 164 QLNDLYHNHQRTVREKERK-------LVDCHRELEKLNKESRLLNQ------EKSELLVE 210
L L +++ REKE+K ++ EL N+ES N+ E E
Sbjct: 2646 -LQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAE 2704
Query: 211 QGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAK 270
+ +A++ QE + +++ + SL L R +E + K ++ + E E +
Sbjct: 2705 LASYKEKAEKLQEELLVKETNMTSLQKDLSQ---VRDHLAEAKEKL--SILEKEDETEVQ 2759
Query: 271 TANQ----------LMNDFAEKE--TLK---QKQIDEIRDKKTGLGRIIELKSEILSKKQ 315
+ + L A + TLK Q +I K G+ I L+SE S++
Sbjct: 2760 ESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQ--INLQSECSSEEV 2817
Query: 316 NELKNVKYE----LQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNE 371
E+ + E +Q+L + IL+++ I +E E K E V+ LK E +L
Sbjct: 2818 TEIISQFTEKIEKMQELHAAE--ILDMESRHI-SETETLKREHYVAVQLLKEECGTL--- 2871
Query: 372 KADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSD--------E 423
KA + K + +L H +T+ + +D + I S+ D E
Sbjct: 2872 KAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEE 2931
Query: 424 LTSLLGYFPNK-KQLEDWLHSKSKEINQTRDRLAKLNKELASS-------EQNKNHINNE 475
S FP K K L +H++ ++ + ++ + E+ K +IN
Sbjct: 2932 SESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTI 2991
Query: 476 LKRKE---EQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFIT 532
K+ + E +++D SQ ES D E + + Q+ L + + + F T
Sbjct: 2992 SSLKDLITKMQLQREAEVYD--SSQSHESFSDWRGELL--LALQQVFLEERSVLLAAFRT 3047
Query: 533 QLT-----DENQSCCPVCQRVFQTEAELQEVISDLQ--------SKLRLAPDKLKSTESE 579
+LT D + QR+ + E Q + LQ S+++ ++ +
Sbjct: 3048 ELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKIT 3107
Query: 580 LKKK---EKRRDEMLGL-VPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETL 635
LK++ EK E+L + +QS + + E+ ++++ + + K + E ++
Sbjct: 3108 LKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSE 3167
Query: 636 LG-TIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQ 694
L T + E + K + +E F++E+KD ++ L+ T+ ++ +
Sbjct: 3168 LAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHL---------LNDTLASEQKKSR 3218
Query: 695 EKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVE 754
E Q L+ K +L R +D++E ++ LK + K LQ++ L++++QL ++ +
Sbjct: 3219 ELQWALE--KEKAKLGRSEERDKEE-LEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQ 3275
Query: 755 LSTEVQSLY-REIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVK 813
+ LY ++ + + + L+ LE S K+ +++ ++ +
Sbjct: 3276 KIESQRMLYDAQLSEEQGRNLELQVLLE---------------SEKVRIREMSSTLDRER 3320
Query: 814 NIHGYMKDIENYIQ--------DGKDDYKKQKETELNKVIAQLSECEKHK-------EKI 858
+H ++ + Q D + +KQ E + ++++ L+E EK+K +++
Sbjct: 3321 ELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQM 3380
Query: 859 NEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEH 918
+D ++ R+ + T++ + N +K+ EL+ E+ ++ L+E Q QV ++ E
Sbjct: 3381 EKDRQVHRKTLQTEQ------EANTEGQKKMHELQSKVEDLQRQLEEKRQ-QVYKLDLEG 3433
Query: 919 QKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREP 956
Q+L+ + ++ L R++ E I + + L EP
Sbjct: 3434 QRLQGIMQEFQKQE---LEREEKRESRRILY-QNLNEP 3467
Score = 76.3 bits (186), Expect = 2e-13
Identities = 178/958 (18%), Positives = 383/958 (39%), Gaps = 125/958 (13%)
Query: 56 VRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNR 115
V QT+ K+ Q + L+ +E + + S +Q+T+ ++I +++++L L++
Sbjct: 1272 VLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDL 1331
Query: 116 LKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHN---- 171
K KL+ +++ L+S +++ E E+ E ++L + +
Sbjct: 1332 EKT---------KLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPP 1382
Query: 172 ----HQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRA 227
+ E + + K N + + + + E ++L ++QE +
Sbjct: 1383 SLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEE 1442
Query: 228 RD-----SLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQE--GEAKTANQLMNDFA 280
S+ + A Q EL G + K H + ++ Q E K + + F
Sbjct: 1443 EVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIG-FQ 1501
Query: 281 EKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQ 340
ET+ K +E + LG E EIL + + S D +L + +
Sbjct: 1502 TFETVDVKFKEEFKPLSKELG---EHGKEILLSNSDP--------HDIPESKDCVLTISE 1550
Query: 341 ELIKAER----------ELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLN 390
E+ ++ E+S + +++ + + E L++ + +L R ++ Q E L
Sbjct: 1551 EMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEE-QLEDMRQELVRQYQEHQQATELLR 1609
Query: 391 HHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQ 450
QME +D+ E+I+++ +QL ++ +
Sbjct: 1610 Q--AHMRQMERQREDQEQLQEEIKRLN-----------------RQLAQRSSIDNENLVS 1650
Query: 451 TRDRLAKLNKELASSEQ----NKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRL 506
R+R+ L +EL + +Q + + EL+ Q + + +V E +LDR
Sbjct: 1651 ERERV--LLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRK 1708
Query: 507 KEEI--EKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVIS---- 560
E++ E S +R L A N + V +T A ++E I
Sbjct: 1709 PEDVPPEILSNERYALQKA--------------NNRLLKILLEVVKTTAAVEETIGRHVL 1754
Query: 561 ---DLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELR-NKLQ 616
D SK + + + +E+E K +E + +SI ++P N
Sbjct: 1755 GILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTD--ESIPSYSGSDMPRNDINMWS 1812
Query: 617 NVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAK 676
V + L + I PE E + I R Q ++ + I++ +++
Sbjct: 1813 KVTEEGTELSQRLVRSGFAGTEIDPENEELML-----NISSRLQAAVEKLLEAISETSSQ 1867
Query: 677 LQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKL 736
L+ + +T + + + ++KQ +++ + EL +L ++ + + Q EL +
Sbjct: 1868 LEHAKVTQT-ELMRESFRQKQEATESLKCQEELRERLHEESRAREQ----LAVELSKAEG 1922
Query: 737 QISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNT 796
I + E Q E + + L +E+ A ++ LE ++ Q+E+E L +K
Sbjct: 1923 VIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEA 1982
Query: 797 SNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQ---KETELNKVIAQLSECEK 853
A + ++ + + +++ + +DD +KQ E ++ + +++ E E+
Sbjct: 1983 MKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQ 2042
Query: 854 HKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVL- 912
K D+R Q ++ Q + R D + + +E ++V ++ Q L++ Q++V+
Sbjct: 2043 EKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHE--RDVFQQEIQKLEQ--QLKVVP 2098
Query: 913 --QMKSEHQ--KLEENIDNIKRN----HNLALGRQKGYEEEIIHFKKELREPQFRDAE 962
Q SEHQ ++E+ +++K L L +++ + +I +E+ + +FR E
Sbjct: 2099 RFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQ-LQRDIQERNEEIEKLEFRVRE 2155
Score = 68.9 bits (167), Expect = 3e-11
Identities = 200/996 (20%), Positives = 408/996 (40%), Gaps = 154/996 (15%)
Query: 63 KVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHN 122
++ E Q E++ L+Q +++ + ++ +E QL + + L+ ++KE E++
Sbjct: 720 QINELQKEIEILRQEEKEKGTLEQEV--QELQL------------KTELLEKQMKEKEND 765
Query: 123 L-SKIMKLDNEIKALDSRKKQME---KDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVRE 178
L K +L+ E L KK +E K ++ + ++ +F L+ + + +V E
Sbjct: 766 LQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIF------LDSIKSKSKDSVWE 819
Query: 179 KERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQ 238
KE +++ E E L ++ LN+E +E+ R + ++ L + A
Sbjct: 820 KEIEIL--IEENEDLKQQCIQLNEE-----IEKQRNTFSFAEKNFEVNYQE-LQEEYACL 871
Query: 239 LELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKT 298
L++ ++++++ KL +E + N T+K K + KT
Sbjct: 872 LKVKDDLEDSKNKQELEYKSKLKALNEELHLQRIN--------PTTVKMKS-SVFDEDKT 922
Query: 299 GLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNV 358
+ +E+ E++ K EL +++LE + LEL Q L +L +K+ +
Sbjct: 923 FVAETLEM-GEVVEKDTTEL------MEKLEVTKREKLELSQRLSDLSEQLK--QKHGEI 973
Query: 359 ETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQM----------EMLTKDKAD 408
L EV SL+ EK + R+L+ +NH+ Q ++T
Sbjct: 974 SFLNEEVKSLKQEKEQVSLRCRELE---IIINHNRAENVQSCDTQVSSLLDGVVTMTSRG 1030
Query: 409 KDEQIRKIKSRHSDELTSLLGYFPNKKQLEDW-LHSKSKEINQTRDRLAKLNKELASSEQ 467
+ + K+ +E ++ +K E+ + +SK+ D L + KE +S
Sbjct: 1031 AEGSVSKVNKSFGEESKIMV---EDKVSFENMTVGEESKQEQLILDHLPSVTKE-SSLRA 1086
Query: 468 NKNHINNELKRKEEQLSSYEDKL------FDVCGSQDFESDLDRLKEEIEKSSKQRAMLA 521
+ N++L+++ L S ++ L +C S + + +D+++E +E +
Sbjct: 1087 TQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSL 1146
Query: 522 GATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEV--ISDLQSKLRLAPDKL-KSTES 578
+++Q + Q++ Q E + + D L L KL K+
Sbjct: 1147 KEELIFAQ---------EEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSE 1197
Query: 579 ELKKKEKRRDEMLG--LVPMRQSIIDLKEKE-----IPELRN-KLQNVNRDIQRLKNDIE 630
E + +LG P + ++ ++KE I E + +LQ+ ++Q + E
Sbjct: 1198 ECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQ---E 1254
Query: 631 EQETLLGTIMPEEESAKVCLTDVTIMERFQ---MELKDVERKIAQQAAKLQGIDLDRTVQ 687
TLL + E V T ++ + Q M+L+ E + ++ + I Q
Sbjct: 1255 NMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIH----SQ 1310
Query: 688 QVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSE-----KLQISTNL 742
N E + HK +SS +L + +++Q ++++ L S+ + E + +I
Sbjct: 1311 MTNLEDIDVNHK-SKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQ 1369
Query: 743 QRRQQLEEQTVELSTEVQSLYREIKDAKEQVSP-------LETTLEKFQQE---KEELIN 792
+R Q + E TV S V S+ DA+ + P ++ T+E F E KEE N
Sbjct: 1370 KRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIE-FSGEFGVKEE-TN 1427
Query: 793 KKNTSNKIAQDKLNDIKEKV---KNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLS 849
K Q++L + KV +I + + I GK++ K+ +
Sbjct: 1428 IVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAH--------A 1479
Query: 850 ECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQM 909
C++ + NE M+L + I Q + + K EE K + +E +H KE
Sbjct: 1480 VCQQEQHYFNE-MKLSQDQIGFQTFETVDV-------KFKEEFKPLSKELGEHGKE---- 1527
Query: 910 QVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKYREMM 969
+L S+ + E+ D + L + + +++ ++ + + + + R++M
Sbjct: 1528 -ILLSNSDPHDIPESKDCV-----LTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLM 1581
Query: 970 IVMRTTELVNKDLDIYYKTLDQA---IMKFHSMKME 1002
+ E + ++L Y+ QA + + H +ME
Sbjct: 1582 LNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQME 1617
Score = 68.6 bits (166), Expect = 3e-11
Identities = 167/863 (19%), Positives = 339/863 (39%), Gaps = 127/863 (14%)
Query: 27 LSEGKALKQKFDEIFSATRYIKALETLRQVRQTQGQKVKEYQMEL---------KYLKQY 77
L EG KQ+ E + + ++ L+T ++ + + ++E L Y
Sbjct: 2649 LLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASY 2708
Query: 78 KEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEH---------------- 121
KEKA ++++++ KE +TS ++ + + L K +L +E
Sbjct: 2709 KEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFE 2768
Query: 122 ----NLSKIM--KLDNEIKALDSRKK----------QMEKDNSELEEKMEKVFQGTDEQL 165
LSK + + D +K S + Q+ + E++ ++ E++
Sbjct: 2769 PLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKI 2828
Query: 166 NDLYHNHQRTVREKERKLVDCHRELEKLNKES----RLLNQEKSELLVEQGRLQ------ 215
+ H + + E + + E E L +E +LL +E L L+
Sbjct: 2829 EKMQELHAAEILDMESRHIS---ETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSS 2885
Query: 216 ----LQADRHQ-EHIRARDS---------LIQSLATQLELDGFERGPFSERQIKNFHKLV 261
+D +Q I + DS L S + +G RG SE +F K +
Sbjct: 2886 IPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEG--RGEESESATDSFPKKI 2943
Query: 262 RERQEGEAKTANQLM----NDFAEKETLKQKQIDE--IRDKKTGLGRIIELKSEILSKKQ 315
+ Q++ + +++ E +Q+ E + ++K + I LK ++++K Q
Sbjct: 2944 KGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLK-DLITKMQ 3002
Query: 316 NELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADL 375
+ + Y+ Q S + + EL+ A +++ E++ + + E+ +L D
Sbjct: 3003 LQREAEVYDSSQ---SHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGT--TDA 3057
Query: 376 DRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKK 435
L L+Q +++ Q M KAD+ + +I++ H+ + ++
Sbjct: 3058 VGLLNCLEQRIQEQG----VEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQE 3113
Query: 436 QLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCG 495
+ I Q + ++ ++ EL+S + + +EQLSS +K+
Sbjct: 3114 SEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATEL-------QEQLSS--EKMV---- 3160
Query: 496 SQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAEL 555
+ +S+L + K E+E + K + + + TDE + T A
Sbjct: 3161 VAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDE-------VHLLNDTLASE 3213
Query: 556 QEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKL 615
Q+ +LQ L +K K SE + KE+ D L +Q + L L +
Sbjct: 3214 QKKSRELQ--WALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLL----LEQQK 3267
Query: 616 QNVNRDIQRLKNDIEEQETLLGTIMPEEE----SAKVCLTDVTIMERFQMELKDVERKIA 671
Q +N Q+ IE Q L + EE+ +V L + R D ER++
Sbjct: 3268 QLLNESQQK----IESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELH 3323
Query: 672 QQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKI-ELNRKLIQDQQEQIQHLKSTTNE 730
Q G R +E Q +L+ S+I EL + + + + +Q + +
Sbjct: 3324 AQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKD 3383
Query: 731 LKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQ------ 784
+ + + T + + +++ EL ++V+ L R++++ ++QV L+ ++ Q
Sbjct: 3384 RQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEF 3443
Query: 785 QEKEELINKKNTSNKIAQDKLND 807
Q++E +K S +I LN+
Sbjct: 3444 QKQELEREEKRESRRILYQNLNE 3466
Score = 65.1 bits (157), Expect = 4e-10
Identities = 140/695 (20%), Positives = 289/695 (41%), Gaps = 117/695 (16%)
Query: 301 GRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVET 360
GR I LK E S+K ++ + ++Y +QQ + ++LE+ EL + ++ ++ + E
Sbjct: 3103 GRKITLKREQESEKPSQ-ELLEYNIQQKQS---QMLEMQVELSSMKDRATELQEQLSSE- 3157
Query: 361 LKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRH 420
KM V L K++L +T +L+ ++ + H + KDK D+ +
Sbjct: 3158 -KMVVAEL---KSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLL------- 3206
Query: 421 SDELTSLLGYFPNKKQLE-DWLHSKSK-----EINQTRDRLAKLNKELASSEQNKNHINN 474
+D L S KK E W K K + ++ L L L S +Q +N
Sbjct: 3207 NDTLAS-----EQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNL 3261
Query: 475 ELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQL 534
L+++++ L+ + K+ SQ D +L EE ++ + + +L + + L
Sbjct: 3262 LLEQQKQLLNESQQKI----ESQRMLYDA-QLSEEQGRNLELQVLLESEKVRIREMSSTL 3316
Query: 535 TDENQSCCPVCQRVFQTEAELQEVISDLQSKLRL-APDKLKSTESELKKKEKRRDEMLGL 593
E + A+LQ QS+ L + D LK + +L++K R
Sbjct: 3317 DRERE-----------LHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSR------- 3358
Query: 594 VPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDV 653
I EL N+ + D + + +E+ + + E+ A
Sbjct: 3359 --------------IVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANT--EGQ 3402
Query: 654 TIMERFQMELKDVERKIAQQAAKLQGIDLD-RTVQQVNQEKQEKQHKLDTVSSKIELNRK 712
M Q +++D++R++ ++ ++ +DL+ + +Q + QE Q+++ + + K E R
Sbjct: 3403 KKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELERE---EKRESRRI 3459
Query: 713 LIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQ 772
L Q+ E T++ ++ LQ + ++ + +E++ E++ +++
Sbjct: 3460 LYQNLNEPTTW-SLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQK 3518
Query: 773 VSPLETTLEKFQQEKEELINKKNTSNKI---AQDKLNDIKEKVKNIHGYMKDIENYIQDG 829
+ + + L+ Q+ E + + ++ Q+ +++I +++ + G + + +
Sbjct: 3519 LQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPS 3578
Query: 830 KD-----DYKKQKETELNKVIAQLSECEKHK-----EKINEDMRLMRQD----------- 868
+ ++ EL I+QL+E EK+ K+ E +R RQ
Sbjct: 3579 TSCGSLTERLLRQNAELTGHISQLTE-EKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFS 3637
Query: 869 ----------IDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEH 918
I ++K E W ++ LTL+K + + + K L+ +Q L SEH
Sbjct: 3638 LNGGANIEAIIASEK--EVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEH 3695
Query: 919 QKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKEL 953
L KR + L R + + + +I+ KK L
Sbjct: 3696 VTL-------KRIYGKYL-RAESFRKALIYQKKYL 3722
Score = 59.7 bits (143), Expect = 2e-08
Identities = 109/507 (21%), Positives = 222/507 (43%), Gaps = 68/507 (13%)
Query: 666 VERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQ-EQIQHL 724
V+ ++Q A+ D ++ + E KQH+++ ++ ++E R + +Q+Q
Sbjct: 141 VDDSYSEQGAQ----DSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEF 196
Query: 725 KSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQ 784
++ + Q++ NLQ+ ++ +++T+ RE + EQ L+ +FQ
Sbjct: 197 EAAIKQRDGIITQLTANLQQARREKDETM----------REFLELTEQSQKLQI---QFQ 243
Query: 785 QEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKV 844
Q + + +T + A D L K+++ +++ ++ ++D Y+K+KE +
Sbjct: 244 QLQASETLRNSTHSSTAADLLQ-AKQQILTHQQQLEEQDHLLED----YQKKKE-DFTMQ 297
Query: 845 IAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEEL--KEVEEERKQ- 901
I+ L E K K+ E M QD + + +Q+ T+ EEL K +EEE+K
Sbjct: 298 ISFLQE----KIKVYE----MEQDKKVENSNKEEIQEKETII---EELNTKIIEEEKKTL 346
Query: 902 HLKE-MGQMQVLQMKSEHQKLEEN--IDNIKRNHNLALGRQKGYEEEIIHFKKELREPQF 958
LK+ + L + + Q +++N I N+K + +++ EEI + E Q
Sbjct: 347 ELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQK 406
Query: 959 RDAEEKYREMMIVMRTTELVNKDLDIYYKTLD-----------QAIMKFHSMKMEEINKI 1007
R+ ++ E IV R + + L+ LD Q +++ H +MEE+
Sbjct: 407 RNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTR 466
Query: 1008 IRDLWRSTYRGQDIEYIEIRSDADE----NVSASD---KRRNYNYRVVMLKGDTALDMRG 1060
+ + R Y I + D+ NV+ ++ K ++ N + LK + L +
Sbjct: 467 HKGEMENALR----SYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEE 522
Query: 1061 RCSAGQKVLASLIIRLALA-ETFCLNCGIIALDEPTTNLDRENIESLAHALVEIIKSRSQ 1119
+C A Q+ L L+ L+ + E IA E N +++ ++ EI+ +
Sbjct: 523 KC-ALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASES 581
Query: 1120 QRNFQLLVITHDEDFVELLGRSEYVEK 1146
++ +L H+ + + E +EK
Sbjct: 582 RKELEL---KHEAEVTNYKIKLEMLEK 605
Score = 51.2 bits (121), Expect = 6e-06
Identities = 196/1039 (18%), Positives = 414/1039 (39%), Gaps = 144/1039 (13%)
Query: 37 FDEIFSATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLT 96
FDE T + LE V + + +++ ++ + + ++ ++ +Q+ K +++
Sbjct: 917 FDE--DKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEIS 974
Query: 97 SSKEIVKSYENELDPLKNRLKEIE----HNLSK-IMKLDNEIKAL--------------- 136
E VKS + E + + R +E+E HN ++ + D ++ +L
Sbjct: 975 FLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGS 1034
Query: 137 --DSRKKQMEKDNSELEEKM--EKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEK 192
K E+ +E+K+ E + G + + L +H +V ++ E +K
Sbjct: 1035 VSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDK 1094
Query: 193 LNKESRLLNQEKSELLVEQGRLQLQADR---------HQEHIR-----ARDSLIQSLATQ 238
L KE +L E+++L RLQ++A R H + +R +D + SL +
Sbjct: 1095 LQKELNVLKSEQNDL-----RLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEE 1149
Query: 239 LELDGFERGPFSERQIKNFHKL----VRERQEG-EAKTANQLMNDFAEKETLKQKQIDEI 293
L E+ ++++ H+L ++ ++ G E K + L+ + + + +
Sbjct: 1150 LIFAQEEK----IKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQT 1205
Query: 294 RDKKTGLGRIIELKSEILSK-KQN-----------ELKNVKYELQQLEGSS----DRILE 337
G LK E+ ++ K+N EL++ +YE+Q + + +++ E
Sbjct: 1206 LCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTE 1265
Query: 338 LDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRT 397
+L+ + LSK + +K+E + L K + E ++ T
Sbjct: 1266 EYNKLLVLQTRLSKI-WGQQTDGMKLEF---------GEENLPKEETEFLSIHSQMTNLE 1315
Query: 398 QMEMLTKDKADKDEQIRKIK-SRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLA 456
+++ K K + + K K EL SL+ ++QL++ + EI+ + RL
Sbjct: 1316 DIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSL--QQQLKETEQNYEAEIHCLQKRLQ 1373
Query: 457 KLNKELASSEQNKNHINNELKRKEEQLSSYEDKLF--DVCGSQDFESDLDRLKEE----- 509
+++ + + + + Q + Y ++ G+ +F + +KEE
Sbjct: 1374 AVSESTVPPSLPVDSV--VITESDAQRTMYPGSCVKKNIDGTIEFSGEFG-VKEETNIVK 1430
Query: 510 -IEKSSKQRAMLAGATAVYSQFI-----TQLT-----DENQSCCPVCQRVFQTEAELQEV 558
+EK +++ A + S I T+L+ EN + V Q E Q
Sbjct: 1431 LLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQE---QHY 1487
Query: 559 ISDLQ-SKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQN 617
++++ S+ ++ ++ + + K++ K + LG + + +IPE ++ +
Sbjct: 1488 FNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLT 1547
Query: 618 VNRDI-QRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAK 676
++ ++ + K I Q + ++++ + + +E + EL + Q
Sbjct: 1548 ISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQEL------VRQYQEH 1601
Query: 677 LQGIDLDRTVQQVNQEKQ-EKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEK 735
Q +L R E+Q E Q +L + LNR+L Q ++L S + E+
Sbjct: 1602 QQATELLRQAHMRQMERQREDQEQLQEEIKR--LNRQLAQRSSIDNENLVSERERVLLEE 1659
Query: 736 LQI--STNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQE--KEELI 791
L+ +L R++L + ST+ Q+ + +EQ E L++ ++ E L
Sbjct: 1660 LEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFK-EKELDRKPEDVPPEILS 1718
Query: 792 NKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKD-DYKKQKETEL---NKVIAQ 847
N++ K L + E VK + I ++ D K Q L ++ A
Sbjct: 1719 NERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEAS 1778
Query: 848 LSEC--EKHKEKINEDM------RLMRQDIDT-QKIQERWLQDNLTLRKRNEELKEVEEE 898
+ C E+H +E + + R DI+ K+ E + + L + E++ E
Sbjct: 1779 VKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPE 1838
Query: 899 RKQHLKEMGQM------QVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKE 952
++ + + ++L+ SE E+ + RQK E + ++E
Sbjct: 1839 NEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEE 1898
Query: 953 LREPQFRDAEEKYREMMIV 971
LRE E + RE + V
Sbjct: 1899 LRERLHE--ESRAREQLAV 1915
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 129 bits (323), Expect = 2e-29
Identities = 185/926 (19%), Positives = 403/926 (43%), Gaps = 104/926 (11%)
Query: 78 KEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDN-----E 132
+E+ + D + + AQ S ++ E+EL ++ ++E+ L ++ +
Sbjct: 135 REEEFGVDDSYSEQGAQ--DSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQ 192
Query: 133 IKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEK 192
++ ++ KQ + ++L +++ + DE + + + E+ +KL + ++
Sbjct: 193 LQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLE-----LTEQSQKL---QIQFQQ 244
Query: 193 LNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSER 252
L L N S + + + Q HQ+ + +D L++ + E D + F +
Sbjct: 245 LQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKE-DFTMQISFLQE 303
Query: 253 QIKNFHKLVRERQEGEAKTANQLMNDFAEKETL----------KQKQIDEIRDKKTGLGR 302
+IK + E + K N + EKET+ ++K+ E++DK T +
Sbjct: 304 KIKVYE------MEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADK 357
Query: 303 II-ELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETL 361
++ EL+ +I+ K Q E+KN+K EL + + E ++L+ EL K N +
Sbjct: 358 LLGELQEQIVQKNQ-EIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQK----RNHKDS 412
Query: 362 KMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHS 421
+ E +Q + + R L +L E++++ + + E++ + A Q+ ++K+RH
Sbjct: 413 QFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMA----QMEEMKTRHK 468
Query: 422 DELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEE 481
E+ + L + N ED + + IN+ LN +L + K + EL E
Sbjct: 469 GEMENALRSYSNITVNEDQIKLMNVAINE-------LNIKLQDTNSQKEKLKEELGLILE 521
Query: 482 QLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSC 541
+ + + +L +D +L +E+I+++ + A + ++ + D
Sbjct: 522 EKCALQRQL------EDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEI 575
Query: 542 CPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSII 601
+ + E + + +++ + KL + + + + + ++ E L R ++
Sbjct: 576 VSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERL-----RTQLL 630
Query: 602 DLKEKEIPELRNKLQNVNR-DIQRLKNDI----EEQETLLGTIMPEEESAKVCLTDVTIM 656
E+E+ +L+ L+ +R +I++LK+++ ++Q L M ++ D I
Sbjct: 631 FSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLIT 690
Query: 657 ERFQM-----ELKDVERKIAQQAAK---LQGIDLDRTVQQVNQEKQEK---QHKLDTVSS 705
++ Q+ +LKD+++ + ++ LQ +L + ++ + QE++EK + ++ +
Sbjct: 691 KQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQL 750
Query: 706 KIELNRKLIQ----DQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQS 761
K EL K ++ D QE+ L++ + LK EK + L+ +S E +
Sbjct: 751 KTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIH-------TPVSQEERL 803
Query: 762 LYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIH-GYMK 820
++ + +K + S E +E +E E+L + N+ + + N KN Y +
Sbjct: 804 IFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQE 863
Query: 821 DIENY-----IQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDI------ 869
E Y ++D +D K ++E E + L+E E H ++IN M+ +
Sbjct: 864 LQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNE-ELHLQRINPTTVKMKSSVFDEDKT 922
Query: 870 ---DTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENID 926
+T ++ E +D L ++ E K + E Q L ++ + Q+ Q E L E +
Sbjct: 923 FVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSE-QLKQKHGEISFLNEEVK 981
Query: 927 NIKRNHNLALGRQKGYEEEIIHFKKE 952
++K+ R + E I H + E
Sbjct: 982 SLKQEKEQVSLRCRELEIIINHNRAE 1007
Score = 127 bits (320), Expect = 5e-29
Identities = 199/959 (20%), Positives = 420/959 (43%), Gaps = 139/959 (14%)
Query: 27 LSEGKALKQKFDEIFSATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRD 86
+++ + +++ F + AT +K E LR+ + + ++ +EL + + D
Sbjct: 1873 VTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYA---D 1929
Query: 87 QITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKD 146
+ T E Q+ +I+ E EL NRL+E+E ++ ++ E + L +K+ M+ +
Sbjct: 1930 EKTLFERQIQEKTDIIDRLEQELLCASNRLQELE---AEQQQIQEERELLSRQKEAMKAE 1986
Query: 147 NSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRE--LEKLNKESRLLNQEK 204
+E+++ Q T++ + KE+ V C E + L K+ + L +
Sbjct: 1987 AGPVEQQL---LQETEKLM-------------KEKLEVQCQAEKVRDDLQKQVKALEIDV 2030
Query: 205 SELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRER 264
E + ++L+ +++ E + R Q+L QLE R E+ I H+ R+
Sbjct: 2031 EEQV--SRFIELEQEKNTELMDLRQQ-NQALEKQLEK---MRKFLDEQAIDREHE--RDV 2082
Query: 265 QEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYE 324
+ E + Q + + + + Q E+ L + SE+L K+ ++++
Sbjct: 2083 FQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQER 2142
Query: 325 LQQLEGSSDRILELDQEL----------IKAERELS-----KAEKNSNVETLKMEVISLQ 369
+++E R+ EL+Q L ++A+ ELS +AE+++ ++ + E+ +L+
Sbjct: 2143 NEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDA-IDRKEKEITNLE 2201
Query: 370 NEKADLDRTLRKLDQEMEQLN-------HHTTTRTQMEMLTKDKADKDEQ------IRKI 416
+ L ++E++QL+ +TTR Q E+ ++K KD+ I++
Sbjct: 2202 EQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQ-ELEQENKLFKDDMEKLGLAIKES 2260
Query: 417 KSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQN-----KNH 471
+ + + L G F + K EI+Q +++ KL ++L + N KN
Sbjct: 2261 DAMSTQDQHVLFGKF------AQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNE 2314
Query: 472 INNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFI 531
+ +L+ + E L S ++ C ++ E ++++L E IEK ++ A + T++ +
Sbjct: 2315 LIRDLETQIECLMSDQE-----CVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAH-- 2367
Query: 532 TQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEML 591
L++E S V + L++ + ++ + LK T K + E+
Sbjct: 2368 -SLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNF---KMNQLTQELF 2423
Query: 592 GLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLT 651
L R+S+ K + IPE +VN I L D E E +L E A L
Sbjct: 2424 SLKRERESV--EKIQSIPE-----NSVNVAIDHLSKDKPELEVVL------TEDALKSLE 2470
Query: 652 DVTIMERFQMELK----DVERKIAQQAAKLQGIDLDRT--VQQVNQEKQEKQHKLDTVSS 705
+ T + F+ K ++E ++ Q + + DL+ T +Q+ +++ Q + + +
Sbjct: 2471 NQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQK 2530
Query: 706 KIELNRKLIQDQ-------QEQIQHLKSTTNELKSEKLQIS----TNLQRRQQLEEQTVE 754
KI +K+++++ Q Q++ ++ + + S TN+Q QL E E
Sbjct: 2531 KIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLRED--E 2588
Query: 755 LSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKN 814
L +++ +L I + + QV + T+L ++E+ E+ K ++ EK K
Sbjct: 2589 LGSDISALTLRISELESQVVEMHTSL-ILEKEQVEIAEK-------------NVLEKEKK 2634
Query: 815 IHGYMKDIENYIQDGKDDYKKQ--KETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQ 872
+ K +E + ++ KK+ ++ E+ K +L + NE L + + T+
Sbjct: 2635 LLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATK 2694
Query: 873 ------KIQERWLQDNLTLRKRN-EELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEEN 924
K + LQ+ L +++ N L++ + + HL E + + K + +++E+
Sbjct: 2695 AELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQES 2753
Score = 119 bits (297), Expect = 2e-26
Identities = 209/1048 (19%), Positives = 452/1048 (43%), Gaps = 153/1048 (14%)
Query: 90 SKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSE 149
++E L S + + E L+ + ++EH +K+ + E+ R+KQ ++ +
Sbjct: 1839 NEELMLNISSRLQAAVEKLLEAISETSSQLEH--AKVTQ--TELMRESFRQKQEATESLK 1894
Query: 150 LEEKMEKVFQGTDEQLNDLYHNHQRTVRE--KERKLVDCHRELEKL-----NKESRLLNQ 202
+E++ E+L++ ++ E K ++D + + + L +++ ++++
Sbjct: 1895 CQEELR-------ERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDR 1947
Query: 203 EKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVR 262
+ ELL RLQ + + Q+ I+ L L+ Q E E GP ++ ++ KL++
Sbjct: 1948 LEQELLCASNRLQ-ELEAEQQQIQEEREL---LSRQKEAMKAEAGPVEQQLLQETEKLMK 2003
Query: 263 ERQEGEAKTANQLMNDFAEKETLKQKQIDEIR-DKKTGLGRIIELKSEILSKKQNELKNV 321
E+ E + + A ++ +D QKQ+ + D + + R IEL+ E K EL ++
Sbjct: 2004 EKLEVQCQ-AEKVRDDL-------QKQVKALEIDVEEQVSRFIELEQE----KNTELMDL 2051
Query: 322 KYELQQLEGSSDRILE-LDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLR 380
+ + Q LE +++ + LD++ I E E ++ ++ L+ ++ + + + R
Sbjct: 2052 RQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQE--IQKLEQQLKVVPRFQPISEHQTR 2109
Query: 381 KLDQEMEQLNHHTTTRTQM----EMLTKDKADKDEQIRKIKSRHSDELTSLL-------G 429
+++Q L T +++ E L +D +++E+I K++ R + +LL G
Sbjct: 2110 EVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFG 2169
Query: 430 YFPNKKQLE---------DWLHSKSKEINQTRDRLAKLNKELASS--EQNKNHINNELKR 478
K +L D + K KEI ++L + +EL + E + H+ E+++
Sbjct: 2170 AVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQK 2229
Query: 479 KEE----QLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQL 534
KE Q E+KLF D E +KE S++ + +L G ++Q I +
Sbjct: 2230 KESTTRLQELEQENKLF----KDDMEKLGLAIKESDAMSTQDQHVLFGK---FAQIIQEK 2282
Query: 535 TDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPD-KLKSTESELKKKEKRRDEMLGL 593
E +L E ++ LQ +L++ D K+ ++EL + + + E L
Sbjct: 2283 EVEID--------------QLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECL-- 2326
Query: 594 VPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDV 653
+ ++ + +E+EI +L ++ + +++ +I ++ ++ + EE + DV
Sbjct: 2327 MSDQECVKRNREEEIEQLNEVIEKLQQELA----NIGQKTSMNAHSLSEEADSLKHQLDV 2382
Query: 654 TIMERF----QMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQ--HKLDTV---- 703
I E+ Q+E + E + K +++ Q++ K+E++ K+ ++
Sbjct: 2383 VIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENS 2442
Query: 704 ---------SSKIELNRKLIQDQQEQIQ---HLKSTTNELKSEKLQISTNLQRRQQLEEQ 751
K EL L +D + ++ + KS K + + T L QLE
Sbjct: 2443 VNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLL---QLEST 2499
Query: 752 TVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEK 811
E+ Y++IKD +EQ L+K ++++ +K + ++Q +L ++E
Sbjct: 2500 VSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEY 2559
Query: 812 VKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDT 871
K + QD + + + T + + QL E +++ D+ + I
Sbjct: 2560 AK-----------FCQDNQTISSEPERTNIQN-LNQLRE-----DELGSDISALTLRISE 2602
Query: 872 QKIQERWLQDNLTLRKRNEELKE---VEEERK----QHLKEMGQMQVLQMKSEHQKLEEN 924
+ Q + +L L K E+ E +E+E+K Q L E + + Q + E ++ ++
Sbjct: 2603 LESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKK--QREKEKKRSPQD 2660
Query: 925 IDNIKRNHNL-ALGRQKGYEEEIIHFKKE-----LREPQFRDAEEKYREMMIVMRTT-EL 977
++ +K L + G+ E+ + E +++ EK +E ++V T
Sbjct: 2661 VEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTS 2720
Query: 978 VNKDLDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQDIEYIE-IRSDADENVSA 1036
+ KDL L +A K ++ E+ ++ + I+ + I S D +
Sbjct: 2721 LQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKI 2780
Query: 1037 SDKRRNYNYRVVMLKGDTALDMRGRCSA 1064
S N ++++ ++++ CS+
Sbjct: 2781 SSS--NQTPQILVKNAGIQINLQSECSS 2806
Score = 102 bits (253), Expect = 3e-21
Identities = 189/978 (19%), Positives = 406/978 (41%), Gaps = 114/978 (11%)
Query: 72 KYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDN 131
K L + +E+ + +I + + +LT+SK+ + E+ L ++E++ K + +
Sbjct: 357 KLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFET 416
Query: 132 EIKALDSRKKQMEKDNSELEEKMEKVF-QGTDEQLNDLYHNHQRTVRE-KERKLVDCHRE 189
+I + +++ ++ +L ++++++ Q + +L H + E K R +
Sbjct: 417 DI--VQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENA 474
Query: 190 LEKLNK------ESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDG 243
L + + +L+N +EL ++ Q ++ +E + +L QLE D
Sbjct: 475 LRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLE-DL 533
Query: 244 FERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRI 303
E FS QI+ + + E QE + A+ K + + D K +
Sbjct: 534 VEELSFSREQIQRARQTIAE-QESKLNEAH--------------KSLSTVEDLKAEIVSA 578
Query: 304 IELKSEILSKKQNELKNVKYELQQLEGSSDRIL---------ELD----QELIKAERELS 350
E + E+ K + E+ N K +L+ LE + +L EL+ Q L E ELS
Sbjct: 579 SESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELS 638
Query: 351 KAEKNSNVETLKMEVISLQNE-----KADLDRTLRKLDQEME--QLNHHTTTRTQMEMLT 403
K +++ +E ++ + L++ K +D ++ Q++E Q Q +++
Sbjct: 639 KLKEDLEIEH-RINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLIL 697
Query: 404 KDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLE-DWLHSKSKEINQTRDRLAKLNKEL 462
+ KD Q + S+ S+E+T + N+ Q E + L + KE + +L +
Sbjct: 698 EISKLKDLQQSLVNSK-SEEMTLQI----NELQKEIEILRQEEKEKGTLEQEVQELQLKT 752
Query: 463 ASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAG 522
E+ N+L+ K QL + L D + ++ D LK S ++R +
Sbjct: 753 ELLEKQMKEKENDLQEKFAQLEAENSILKD-----EKKTLEDMLKIHTPVSQEERLIFLD 807
Query: 523 A------TAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKST 576
+ +V+ + I L +EN+ C +L E I ++ A +
Sbjct: 808 SIKSKSKDSVWEKEIEILIEENEDLKQQC-------IQLNEEIEKQRNTFSFAEKNFEVN 860
Query: 577 ESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQ---------RLKN 627
EL ++E L+ ++ + D K K+ E ++KL+ +N ++ ++K+
Sbjct: 861 YQEL------QEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKS 914
Query: 628 DIEEQ------ETL-LGTIMPEEESAKVCLTDVTIMERFQM--ELKDVERKIAQQAAKLQ 678
+ ++ ETL +G ++ ++ + + +VT E+ ++ L D+ ++ Q+ ++
Sbjct: 915 SVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEIS 974
Query: 679 GIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNR-KLIQDQQEQIQHLKSTTNELKSEKLQ 737
L+ V+ + QEK++ + + I NR + +Q Q+ L + S +
Sbjct: 975 --FLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAE 1032
Query: 738 ISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTS 797
S + + EE + + +V + + +Q + L +E + + +
Sbjct: 1033 GSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSEN 1092
Query: 798 NKIAQDKLNDIKEKVKNIHGYMKD----IENYIQDGKDDYKKQKETELNKVIAQLSE--C 851
+K+ Q +LN +K + ++ M+ + D ++ E E +K + L E
Sbjct: 1093 DKL-QKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELI 1151
Query: 852 EKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKE----MG 907
+EKI E ++ + ++ T K QE + + K V EE L+ +G
Sbjct: 1152 FAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLG 1211
Query: 908 QMQVLQMKSE--HQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKY 965
+ +K E + E + D I N + L + Y E+ F++ + + EE
Sbjct: 1212 EYYTPALKCEVNAEDKENSGDYISENEDPEL---QDYRYEVQDFQENMHTLLNKVTEEYN 1268
Query: 966 REMMIVMRTTELVNKDLD 983
+ +++ R +++ + D
Sbjct: 1269 KLLVLQTRLSKIWGQQTD 1286
Score = 79.7 bits (195), Expect = 1e-14
Identities = 206/998 (20%), Positives = 428/998 (42%), Gaps = 157/998 (15%)
Query: 48 KALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYEN 107
K + L+++ + + Q++L+ +++Y K C+ +Q S E + T+ + + + E+
Sbjct: 2530 KKIVNLQKIVEEKVAAALVSQIQLEAVQEYA-KFCQ-DNQTISSEPERTNIQNLNQLRED 2587
Query: 108 EL----DPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDE 163
EL L R+ E+E S+++++ +L K+Q+E + EK +K+ +
Sbjct: 2588 ELGSDISALTLRISELE---SQVVEMHT---SLILEKEQVEIAEKNVLEKEKKLLE---- 2637
Query: 164 QLNDLYHNHQRTVREKERK-------LVDCHRELEKLNKESRLLNQ------EKSELLVE 210
L L +++ REKE+K ++ EL N+ES N+ E E
Sbjct: 2638 -LQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAE 2696
Query: 211 QGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAK 270
+ +A++ QE + +++ + SL L R +E + K ++ + E E +
Sbjct: 2697 LASYKEKAEKLQEELLVKETNMTSLQKDLSQ---VRDHLAEAKEKL--SILEKEDETEVQ 2751
Query: 271 TANQ----------LMNDFAEKE--TLK---QKQIDEIRDKKTGLGRIIELKSEILSKKQ 315
+ + L A + TLK Q +I K G+ I L+SE S++
Sbjct: 2752 ESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQ--INLQSECSSEEV 2809
Query: 316 NELKNVKYE----LQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNE 371
E+ + E +Q+L + IL+++ I +E E K E V+ LK E +L
Sbjct: 2810 TEIISQFTEKIEKMQELHAAE--ILDMESRHI-SETETLKREHYVAVQLLKEECGTL--- 2863
Query: 372 KADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSD--------E 423
KA + K + +L H +T+ + +D + I S+ D E
Sbjct: 2864 KAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEE 2923
Query: 424 LTSLLGYFPNK-KQLEDWLHSKSKEINQTRDRLAKLNKELASS-------EQNKNHINNE 475
S FP K K L +H++ ++ + ++ + E+ K +IN
Sbjct: 2924 SESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTI 2983
Query: 476 LKRKE---EQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFIT 532
K+ + E +++D SQ ES D E + + Q+ L + + + F T
Sbjct: 2984 SSLKDLITKMQLQREAEVYD--SSQSHESFSDWRGELL--LALQQVFLEERSVLLAAFRT 3039
Query: 533 QLT-----DENQSCCPVCQRVFQTEAELQEVISDLQ--------SKLRLAPDKLKSTESE 579
+LT D + QR+ + E Q + LQ S+++ ++ +
Sbjct: 3040 ELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKIT 3099
Query: 580 LKKK---EKRRDEMLGL-VPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETL 635
LK++ EK E+L + +QS + + E+ ++++ + + K + E ++
Sbjct: 3100 LKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSE 3159
Query: 636 LG-TIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQ 694
L T + E + K + +E F++E+KD ++ L+ T+ ++ +
Sbjct: 3160 LAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHL---------LNDTLASEQKKSR 3210
Query: 695 EKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVE 754
E Q L+ K +L R +D++E ++ LK + K LQ++ L++++QL ++ +
Sbjct: 3211 ELQWALE--KEKAKLGRSEERDKEE-LEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQ 3267
Query: 755 LSTEVQSLY-REIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVK 813
+ LY ++ + + + L+ LE S K+ +++ ++ +
Sbjct: 3268 KIESQRMLYDAQLSEEQGRNLELQVLLE---------------SEKVRIREMSSTLDRER 3312
Query: 814 NIHGYMKDIENYIQ--------DGKDDYKKQKETELNKVIAQLSECEKHK-------EKI 858
+H ++ + Q D + +KQ E + ++++ L+E EK+K +++
Sbjct: 3313 ELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQM 3372
Query: 859 NEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEH 918
+D ++ R+ + T++ + N +K+ EL+ E+ ++ L+E Q QV ++ E
Sbjct: 3373 EKDRQVHRKTLQTEQ------EANTEGQKKMHELQSKVEDLQRQLEEKRQ-QVYKLDLEG 3425
Query: 919 QKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREP 956
Q+L+ + ++ L R++ E I + + L EP
Sbjct: 3426 QRLQGIMQEFQKQE---LEREEKRESRRILY-QNLNEP 3459
Score = 76.3 bits (186), Expect = 2e-13
Identities = 178/958 (18%), Positives = 383/958 (39%), Gaps = 125/958 (13%)
Query: 56 VRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNR 115
V QT+ K+ Q + L+ +E + + S +Q+T+ ++I +++++L L++
Sbjct: 1272 VLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDL 1331
Query: 116 LKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHN---- 171
K KL+ +++ L+S +++ E E+ E ++L + +
Sbjct: 1332 EKT---------KLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPP 1382
Query: 172 ----HQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRA 227
+ E + + K N + + + + E ++L ++QE +
Sbjct: 1383 SLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEE 1442
Query: 228 RD-----SLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQE--GEAKTANQLMNDFA 280
S+ + A Q EL G + K H + ++ Q E K + + F
Sbjct: 1443 EVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIG-FQ 1501
Query: 281 EKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQ 340
ET+ K +E + LG E EIL + + S D +L + +
Sbjct: 1502 TFETVDVKFKEEFKPLSKELG---EHGKEILLSNSDP--------HDIPESKDCVLTISE 1550
Query: 341 ELIKAER----------ELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLN 390
E+ ++ E+S + +++ + + E L++ + +L R ++ Q E L
Sbjct: 1551 EMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEE-QLEDMRQELVRQYQEHQQATELLR 1609
Query: 391 HHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQ 450
QME +D+ E+I+++ +QL ++ +
Sbjct: 1610 Q--AHMRQMERQREDQEQLQEEIKRLN-----------------RQLAQRSSIDNENLVS 1650
Query: 451 TRDRLAKLNKELASSEQ----NKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRL 506
R+R+ L +EL + +Q + + EL+ Q + + +V E +LDR
Sbjct: 1651 ERERV--LLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRK 1708
Query: 507 KEEI--EKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVIS---- 560
E++ E S +R L A N + V +T A ++E I
Sbjct: 1709 PEDVPPEILSNERYALQKA--------------NNRLLKILLEVVKTTAAVEETIGRHVL 1754
Query: 561 ---DLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELR-NKLQ 616
D SK + + + +E+E K +E + +SI ++P N
Sbjct: 1755 GILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTD--ESIPSYSGSDMPRNDINMWS 1812
Query: 617 NVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAK 676
V + L + I PE E + I R Q ++ + I++ +++
Sbjct: 1813 KVTEEGTELSQRLVRSGFAGTEIDPENEELML-----NISSRLQAAVEKLLEAISETSSQ 1867
Query: 677 LQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKL 736
L+ + +T + + + ++KQ +++ + EL +L ++ + + Q EL +
Sbjct: 1868 LEHAKVTQT-ELMRESFRQKQEATESLKCQEELRERLHEESRAREQ----LAVELSKAEG 1922
Query: 737 QISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNT 796
I + E Q E + + L +E+ A ++ LE ++ Q+E+E L +K
Sbjct: 1923 VIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEA 1982
Query: 797 SNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQ---KETELNKVIAQLSECEK 853
A + ++ + + +++ + +DD +KQ E ++ + +++ E E+
Sbjct: 1983 MKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQ 2042
Query: 854 HKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVL- 912
K D+R Q ++ Q + R D + + +E ++V ++ Q L++ Q++V+
Sbjct: 2043 EKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHE--RDVFQQEIQKLEQ--QLKVVP 2098
Query: 913 --QMKSEHQ--KLEENIDNIKRN----HNLALGRQKGYEEEIIHFKKELREPQFRDAE 962
Q SEHQ ++E+ +++K L L +++ + +I +E+ + +FR E
Sbjct: 2099 RFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQ-LQRDIQERNEEIEKLEFRVRE 2155
Score = 68.9 bits (167), Expect = 3e-11
Identities = 200/996 (20%), Positives = 408/996 (40%), Gaps = 154/996 (15%)
Query: 63 KVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHN 122
++ E Q E++ L+Q +++ + ++ +E QL + + L+ ++KE E++
Sbjct: 720 QINELQKEIEILRQEEKEKGTLEQEV--QELQL------------KTELLEKQMKEKEND 765
Query: 123 L-SKIMKLDNEIKALDSRKKQME---KDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVRE 178
L K +L+ E L KK +E K ++ + ++ +F L+ + + +V E
Sbjct: 766 LQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIF------LDSIKSKSKDSVWE 819
Query: 179 KERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQ 238
KE +++ E E L ++ LN+E +E+ R + ++ L + A
Sbjct: 820 KEIEIL--IEENEDLKQQCIQLNEE-----IEKQRNTFSFAEKNFEVNYQE-LQEEYACL 871
Query: 239 LELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKT 298
L++ ++++++ KL +E + N T+K K + KT
Sbjct: 872 LKVKDDLEDSKNKQELEYKSKLKALNEELHLQRIN--------PTTVKMKS-SVFDEDKT 922
Query: 299 GLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNV 358
+ +E+ E++ K EL +++LE + LEL Q L +L +K+ +
Sbjct: 923 FVAETLEM-GEVVEKDTTEL------MEKLEVTKREKLELSQRLSDLSEQLK--QKHGEI 973
Query: 359 ETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQM----------EMLTKDKAD 408
L EV SL+ EK + R+L+ +NH+ Q ++T
Sbjct: 974 SFLNEEVKSLKQEKEQVSLRCRELE---IIINHNRAENVQSCDTQVSSLLDGVVTMTSRG 1030
Query: 409 KDEQIRKIKSRHSDELTSLLGYFPNKKQLEDW-LHSKSKEINQTRDRLAKLNKELASSEQ 467
+ + K+ +E ++ +K E+ + +SK+ D L + KE +S
Sbjct: 1031 AEGSVSKVNKSFGEESKIMV---EDKVSFENMTVGEESKQEQLILDHLPSVTKE-SSLRA 1086
Query: 468 NKNHINNELKRKEEQLSSYEDKL------FDVCGSQDFESDLDRLKEEIEKSSKQRAMLA 521
+ N++L+++ L S ++ L +C S + + +D+++E +E +
Sbjct: 1087 TQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSL 1146
Query: 522 GATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEV--ISDLQSKLRLAPDKL-KSTES 578
+++Q + Q++ Q E + + D L L KL K+
Sbjct: 1147 KEELIFAQ---------EEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSE 1197
Query: 579 ELKKKEKRRDEMLG--LVPMRQSIIDLKEKE-----IPELRN-KLQNVNRDIQRLKNDIE 630
E + +LG P + ++ ++KE I E + +LQ+ ++Q + E
Sbjct: 1198 ECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQ---E 1254
Query: 631 EQETLLGTIMPEEESAKVCLTDVTIMERFQ---MELKDVERKIAQQAAKLQGIDLDRTVQ 687
TLL + E V T ++ + Q M+L+ E + ++ + I Q
Sbjct: 1255 NMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIH----SQ 1310
Query: 688 QVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSE-----KLQISTNL 742
N E + HK +SS +L + +++Q ++++ L S+ + E + +I
Sbjct: 1311 MTNLEDIDVNHK-SKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQ 1369
Query: 743 QRRQQLEEQTVELSTEVQSLYREIKDAKEQVSP-------LETTLEKFQQE---KEELIN 792
+R Q + E TV S V S+ DA+ + P ++ T+E F E KEE N
Sbjct: 1370 KRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIE-FSGEFGVKEE-TN 1427
Query: 793 KKNTSNKIAQDKLNDIKEKV---KNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLS 849
K Q++L + KV +I + + I GK++ K+ +
Sbjct: 1428 IVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAH--------A 1479
Query: 850 ECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQM 909
C++ + NE M+L + I Q + + K EE K + +E +H KE
Sbjct: 1480 VCQQEQHYFNE-MKLSQDQIGFQTFETVDV-------KFKEEFKPLSKELGEHGKE---- 1527
Query: 910 QVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKYREMM 969
+L S+ + E+ D + L + + +++ ++ + + + + R++M
Sbjct: 1528 -ILLSNSDPHDIPESKDCV-----LTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLM 1581
Query: 970 IVMRTTELVNKDLDIYYKTLDQA---IMKFHSMKME 1002
+ E + ++L Y+ QA + + H +ME
Sbjct: 1582 LNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQME 1617
Score = 68.6 bits (166), Expect = 3e-11
Identities = 167/863 (19%), Positives = 339/863 (39%), Gaps = 127/863 (14%)
Query: 27 LSEGKALKQKFDEIFSATRYIKALETLRQVRQTQGQKVKEYQMEL---------KYLKQY 77
L EG KQ+ E + + ++ L+T ++ + + ++E L Y
Sbjct: 2641 LLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASY 2700
Query: 78 KEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEH---------------- 121
KEKA ++++++ KE +TS ++ + + L K +L +E
Sbjct: 2701 KEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFE 2760
Query: 122 ----NLSKIM--KLDNEIKALDSRKK----------QMEKDNSELEEKMEKVFQGTDEQL 165
LSK + + D +K S + Q+ + E++ ++ E++
Sbjct: 2761 PLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKI 2820
Query: 166 NDLYHNHQRTVREKERKLVDCHRELEKLNKES----RLLNQEKSELLVEQGRLQ------ 215
+ H + + E + + E E L +E +LL +E L L+
Sbjct: 2821 EKMQELHAAEILDMESRHIS---ETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSS 2877
Query: 216 ----LQADRHQ-EHIRARDS---------LIQSLATQLELDGFERGPFSERQIKNFHKLV 261
+D +Q I + DS L S + +G RG SE +F K +
Sbjct: 2878 IPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEG--RGEESESATDSFPKKI 2935
Query: 262 RERQEGEAKTANQLM----NDFAEKETLKQKQIDE--IRDKKTGLGRIIELKSEILSKKQ 315
+ Q++ + +++ E +Q+ E + ++K + I LK ++++K Q
Sbjct: 2936 KGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLK-DLITKMQ 2994
Query: 316 NELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADL 375
+ + Y+ Q S + + EL+ A +++ E++ + + E+ +L D
Sbjct: 2995 LQREAEVYDSSQ---SHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGT--TDA 3049
Query: 376 DRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKK 435
L L+Q +++ Q M KAD+ + +I++ H+ + ++
Sbjct: 3050 VGLLNCLEQRIQEQG----VEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQE 3105
Query: 436 QLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCG 495
+ I Q + ++ ++ EL+S + + +EQLSS +K+
Sbjct: 3106 SEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATEL-------QEQLSS--EKMV---- 3152
Query: 496 SQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAEL 555
+ +S+L + K E+E + K + + + TDE + T A
Sbjct: 3153 VAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDE-------VHLLNDTLASE 3205
Query: 556 QEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKL 615
Q+ +LQ L +K K SE + KE+ D L +Q + L L +
Sbjct: 3206 QKKSRELQ--WALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLL----LEQQK 3259
Query: 616 QNVNRDIQRLKNDIEEQETLLGTIMPEEE----SAKVCLTDVTIMERFQMELKDVERKIA 671
Q +N Q+ IE Q L + EE+ +V L + R D ER++
Sbjct: 3260 QLLNESQQK----IESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELH 3315
Query: 672 QQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKI-ELNRKLIQDQQEQIQHLKSTTNE 730
Q G R +E Q +L+ S+I EL + + + + +Q + +
Sbjct: 3316 AQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKD 3375
Query: 731 LKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQ------ 784
+ + + T + + +++ EL ++V+ L R++++ ++QV L+ ++ Q
Sbjct: 3376 RQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEF 3435
Query: 785 QEKEELINKKNTSNKIAQDKLND 807
Q++E +K S +I LN+
Sbjct: 3436 QKQELEREEKRESRRILYQNLNE 3458
Score = 65.1 bits (157), Expect = 4e-10
Identities = 140/695 (20%), Positives = 289/695 (41%), Gaps = 117/695 (16%)
Query: 301 GRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVET 360
GR I LK E S+K ++ + ++Y +QQ + ++LE+ EL + ++ ++ + E
Sbjct: 3095 GRKITLKREQESEKPSQ-ELLEYNIQQKQS---QMLEMQVELSSMKDRATELQEQLSSE- 3149
Query: 361 LKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRH 420
KM V L K++L +T +L+ ++ + H + KDK D+ +
Sbjct: 3150 -KMVVAEL---KSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLL------- 3198
Query: 421 SDELTSLLGYFPNKKQLE-DWLHSKSK-----EINQTRDRLAKLNKELASSEQNKNHINN 474
+D L S KK E W K K + ++ L L L S +Q +N
Sbjct: 3199 NDTLAS-----EQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNL 3253
Query: 475 ELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQL 534
L+++++ L+ + K+ SQ D +L EE ++ + + +L + + L
Sbjct: 3254 LLEQQKQLLNESQQKI----ESQRMLYDA-QLSEEQGRNLELQVLLESEKVRIREMSSTL 3308
Query: 535 TDENQSCCPVCQRVFQTEAELQEVISDLQSKLRL-APDKLKSTESELKKKEKRRDEMLGL 593
E + A+LQ QS+ L + D LK + +L++K R
Sbjct: 3309 DRERE-----------LHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSR------- 3350
Query: 594 VPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDV 653
I EL N+ + D + + +E+ + + E+ A
Sbjct: 3351 --------------IVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANT--EGQ 3394
Query: 654 TIMERFQMELKDVERKIAQQAAKLQGIDLD-RTVQQVNQEKQEKQHKLDTVSSKIELNRK 712
M Q +++D++R++ ++ ++ +DL+ + +Q + QE Q+++ + + K E R
Sbjct: 3395 KKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELERE---EKRESRRI 3451
Query: 713 LIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQ 772
L Q+ E T++ ++ LQ + ++ + +E++ E++ +++
Sbjct: 3452 LYQNLNEPTTW-SLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQK 3510
Query: 773 VSPLETTLEKFQQEKEELINKKNTSNKI---AQDKLNDIKEKVKNIHGYMKDIENYIQDG 829
+ + + L+ Q+ E + + ++ Q+ +++I +++ + G + + +
Sbjct: 3511 LQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPS 3570
Query: 830 KD-----DYKKQKETELNKVIAQLSECEKHK-----EKINEDMRLMRQD----------- 868
+ ++ EL I+QL+E EK+ K+ E +R RQ
Sbjct: 3571 TSCGSLTERLLRQNAELTGHISQLTE-EKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFS 3629
Query: 869 ----------IDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEH 918
I ++K E W ++ LTL+K + + + K L+ +Q L SEH
Sbjct: 3630 LNGGANIEAIIASEK--EVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLLQTLSPDSEH 3687
Query: 919 QKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKEL 953
L KR + L R + + + +I+ KK L
Sbjct: 3688 VTL-------KRIYGKYL-RAESFRKALIYQKKYL 3714
Score = 59.7 bits (143), Expect = 2e-08
Identities = 109/507 (21%), Positives = 222/507 (43%), Gaps = 68/507 (13%)
Query: 666 VERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQ-EQIQHL 724
V+ ++Q A+ D ++ + E KQH+++ ++ ++E R + +Q+Q
Sbjct: 141 VDDSYSEQGAQ----DSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEF 196
Query: 725 KSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQ 784
++ + Q++ NLQ+ ++ +++T+ RE + EQ L+ +FQ
Sbjct: 197 EAAIKQRDGIITQLTANLQQARREKDETM----------REFLELTEQSQKLQI---QFQ 243
Query: 785 QEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKV 844
Q + + +T + A D L K+++ +++ ++ ++D Y+K+KE +
Sbjct: 244 QLQASETLRNSTHSSTAADLLQ-AKQQILTHQQQLEEQDHLLED----YQKKKE-DFTMQ 297
Query: 845 IAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRNEEL--KEVEEERKQ- 901
I+ L E K K+ E M QD + + +Q+ T+ EEL K +EEE+K
Sbjct: 298 ISFLQE----KIKVYE----MEQDKKVENSNKEEIQEKETII---EELNTKIIEEEKKTL 346
Query: 902 HLKE-MGQMQVLQMKSEHQKLEEN--IDNIKRNHNLALGRQKGYEEEIIHFKKELREPQF 958
LK+ + L + + Q +++N I N+K + +++ EEI + E Q
Sbjct: 347 ELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQK 406
Query: 959 RDAEEKYREMMIVMRTTELVNKDLDIYYKTLD-----------QAIMKFHSMKMEEINKI 1007
R+ ++ E IV R + + L+ LD Q +++ H +MEE+
Sbjct: 407 RNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTR 466
Query: 1008 IRDLWRSTYRGQDIEYIEIRSDADE----NVSASD---KRRNYNYRVVMLKGDTALDMRG 1060
+ + R Y I + D+ NV+ ++ K ++ N + LK + L +
Sbjct: 467 HKGEMENALR----SYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEE 522
Query: 1061 RCSAGQKVLASLIIRLALA-ETFCLNCGIIALDEPTTNLDRENIESLAHALVEIIKSRSQ 1119
+C A Q+ L L+ L+ + E IA E N +++ ++ EI+ +
Sbjct: 523 KC-ALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASES 581
Query: 1120 QRNFQLLVITHDEDFVELLGRSEYVEK 1146
++ +L H+ + + E +EK
Sbjct: 582 RKELEL---KHEAEVTNYKIKLEMLEK 605
Score = 51.2 bits (121), Expect = 6e-06
Identities = 196/1039 (18%), Positives = 414/1039 (39%), Gaps = 144/1039 (13%)
Query: 37 FDEIFSATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLT 96
FDE T + LE V + + +++ ++ + + ++ ++ +Q+ K +++
Sbjct: 917 FDE--DKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEIS 974
Query: 97 SSKEIVKSYENELDPLKNRLKEIE----HNLSK-IMKLDNEIKAL--------------- 136
E VKS + E + + R +E+E HN ++ + D ++ +L
Sbjct: 975 FLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGS 1034
Query: 137 --DSRKKQMEKDNSELEEKM--EKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEK 192
K E+ +E+K+ E + G + + L +H +V ++ E +K
Sbjct: 1035 VSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDK 1094
Query: 193 LNKESRLLNQEKSELLVEQGRLQLQADR---------HQEHIR-----ARDSLIQSLATQ 238
L KE +L E+++L RLQ++A R H + +R +D + SL +
Sbjct: 1095 LQKELNVLKSEQNDL-----RLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEE 1149
Query: 239 LELDGFERGPFSERQIKNFHKL----VRERQEG-EAKTANQLMNDFAEKETLKQKQIDEI 293
L E+ ++++ H+L ++ ++ G E K + L+ + + + +
Sbjct: 1150 LIFAQEEK----IKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQT 1205
Query: 294 RDKKTGLGRIIELKSEILSK-KQN-----------ELKNVKYELQQLEGSS----DRILE 337
G LK E+ ++ K+N EL++ +YE+Q + + +++ E
Sbjct: 1206 LCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTE 1265
Query: 338 LDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRT 397
+L+ + LSK + +K+E + L K + E ++ T
Sbjct: 1266 EYNKLLVLQTRLSKI-WGQQTDGMKLEF---------GEENLPKEETEFLSIHSQMTNLE 1315
Query: 398 QMEMLTKDKADKDEQIRKIK-SRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLA 456
+++ K K + + K K EL SL+ ++QL++ + EI+ + RL
Sbjct: 1316 DIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSL--QQQLKETEQNYEAEIHCLQKRLQ 1373
Query: 457 KLNKELASSEQNKNHINNELKRKEEQLSSYEDKLF--DVCGSQDFESDLDRLKEE----- 509
+++ + + + + Q + Y ++ G+ +F + +KEE
Sbjct: 1374 AVSESTVPPSLPVDSV--VITESDAQRTMYPGSCVKKNIDGTIEFSGEFG-VKEETNIVK 1430
Query: 510 -IEKSSKQRAMLAGATAVYSQFI-----TQLT-----DENQSCCPVCQRVFQTEAELQEV 558
+EK +++ A + S I T+L+ EN + V Q E Q
Sbjct: 1431 LLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQE---QHY 1487
Query: 559 ISDLQ-SKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQN 617
++++ S+ ++ ++ + + K++ K + LG + + +IPE ++ +
Sbjct: 1488 FNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLT 1547
Query: 618 VNRDI-QRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAK 676
++ ++ + K I Q + ++++ + + +E + EL + Q
Sbjct: 1548 ISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQEL------VRQYQEH 1601
Query: 677 LQGIDLDRTVQQVNQEKQ-EKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEK 735
Q +L R E+Q E Q +L + LNR+L Q ++L S + E+
Sbjct: 1602 QQATELLRQAHMRQMERQREDQEQLQEEIKR--LNRQLAQRSSIDNENLVSERERVLLEE 1659
Query: 736 LQI--STNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQE--KEELI 791
L+ +L R++L + ST+ Q+ + +EQ E L++ ++ E L
Sbjct: 1660 LEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFK-EKELDRKPEDVPPEILS 1718
Query: 792 NKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKD-DYKKQKETEL---NKVIAQ 847
N++ K L + E VK + I ++ D K Q L ++ A
Sbjct: 1719 NERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEAS 1778
Query: 848 LSEC--EKHKEKINEDM------RLMRQDIDT-QKIQERWLQDNLTLRKRNEELKEVEEE 898
+ C E+H +E + + R DI+ K+ E + + L + E++ E
Sbjct: 1779 VKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPE 1838
Query: 899 RKQHLKEMGQM------QVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKE 952
++ + + ++L+ SE E+ + RQK E + ++E
Sbjct: 1839 NEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEE 1898
Query: 953 LREPQFRDAEEKYREMMIV 971
LRE E + RE + V
Sbjct: 1899 LRERLHE--ESRAREQLAV 1915
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 129 bits (323), Expect = 2e-29
Identities = 165/798 (20%), Positives = 351/798 (43%), Gaps = 109/798 (13%)
Query: 286 KQKQIDEIRDKKTGLGRI---IELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQ-E 341
K ++I ++R K + + L S+ L + +EL + + + S+ ++L+ + E
Sbjct: 1259 KDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAE 1318
Query: 342 LIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEM 401
++AE+E+ + + + +MEV+ ++ +A L R +++ E++ + R + E
Sbjct: 1319 RLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAA-EINGEVDDDDAGGEWRLKYER 1377
Query: 402 LTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKE 461
++ D ++++ D+L NK+QLE L + +++ L +L K+
Sbjct: 1378 AVREV---DFTKKRLQQEFEDKLEVEQ---QNKRQLERRLGDLQADSEESQRALQQLKKK 1431
Query: 462 L----ASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQR 517
A + K H+ + R E + + FD SQ E + R K + EK +++
Sbjct: 1432 CQRLTAELQDTKLHLEGQQVRNHEL--EKKQRRFDSELSQAHE-EAQREKLQREKLQREK 1488
Query: 518 AMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDL---QSKLRLAPDKLK 574
ML Q QL +++ Q+V EAELQ++ S ++ L +L+
Sbjct: 1489 DMLLAEAFSLKQ---QLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLR 1545
Query: 575 STESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQET 634
E+++K +E+ DE G + M + E E+ +R Q +++++ ++EE
Sbjct: 1546 DLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMR---QTHSKEMESRDEEVEE--- 1599
Query: 635 LLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQ 694
+ + C + ME E + ++K+ ++ +L+G L QVN+
Sbjct: 1600 ----------ARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEG-KLATLSDQVNRRDF 1648
Query: 695 EKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVE 754
E + +L ++ + L+ D Q + HLK++ K E Q+ L+ + V+
Sbjct: 1649 ESEKRL---RKDLKRTKALLADAQLMLDHLKNSAPS-KREIAQLKNQLEESEFTCAAAVK 1704
Query: 755 ----LSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKE 810
+ E++ L+ +I D + + LE L + Q+EK E+ N+ Q+ +N++ +
Sbjct: 1705 ARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEED----QEDMNELMK 1760
Query: 811 KVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDID 870
K K Q +D ++N + AQL E K K+++ E ++ ++ ++
Sbjct: 1761 KHKAA---------VAQASRD------LAQINDLQAQLEEANKEKQELQEKLQALQSQVE 1805
Query: 871 TQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKR 930
E+ + D + ++ +++E+E E + QV +++S +L+EN++ +
Sbjct: 1806 ---FLEQSMVDKSLVSRQEAKIRELETRL-----EFERTQVKRLESLASRLKENMEKLTE 1857
Query: 931 NHNLALGRQKGYEEEIIHFKKELREPQFR---------DAEEKYREMMIVMRTTELVNKD 981
+ + + +E+ +++LR+ + +A K E+ + + + E N+
Sbjct: 1858 ERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQS 1917
Query: 982 LDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQDIEYIEIRSDADENV--SASDK 1039
L QA +K ++ ++ I D E+ SD +E++ S D
Sbjct: 1918 L--------QADLKLAFKRIGDLQAAIED--------------EMESDENEDLINSLQDM 1955
Query: 1040 RRNYNYRVVMLKGDTALD 1057
Y R L+GD+ +D
Sbjct: 1956 VTKYQKRKNKLEGDSDVD 1973
Score = 120 bits (300), Expect = 1e-26
Identities = 183/811 (22%), Positives = 346/811 (42%), Gaps = 110/811 (13%)
Query: 116 LKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRT 175
L E++ + +I D EI+ L S+ ++ EK+ +EL +++ E ++L +R
Sbjct: 1246 LIEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSEL--TDERN 1303
Query: 176 VREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQAD-RHQEHIRARDSLIQS 234
E +L+D E+L E +E EL + L+ Q + E + AR LI++
Sbjct: 1304 TGESASQLLDAETA-ERLRAE-----KEMKELQTQYDALKKQMEVMEMEVMEAR--LIRA 1355
Query: 235 LATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIR 294
E+D + G E ++K + + VRE T +L +F +K ++Q+ ++
Sbjct: 1356 AEINGEVDDDDAG--GEWRLK-YERAVREVDF----TKKRLQQEFEDKLEVEQQNKRQLE 1408
Query: 295 DKKTGLGRIIELKSEILSKKQNELKNVKYELQQ----LEGSSDRILELDQELIKAERELS 350
+ L E L + + + + + ELQ LEG R EL+++ + + ELS
Sbjct: 1409 RRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELS 1468
Query: 351 KAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKD 410
+A + + E L+ E LQ EK L L Q++E+ + TQ + +
Sbjct: 1469 QAHEEAQREKLQRE--KLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVV------SLE 1520
Query: 411 EQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKN 470
+++ I S+ S + SL KKQL D L +K K+ + D A + L EQ K
Sbjct: 1521 AELQDISSQESKDEASLAKV---KKQLRD-LEAKVKDQEEELDEQAGTIQML---EQAKL 1573
Query: 471 HINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQF 530
+ E++R + S++ ES + ++E + K+ Q
Sbjct: 1574 RLEMEMERMRQT------------HSKEMESRDEEVEEARQSCQKK----------LKQM 1611
Query: 531 ITQLTDENQSCCPVCQRVFQTEAELQEVIS-----DLQSKLRLAPDKLKSTESELKKKEK 585
QL +E + V + + E +L + D +S+ RL D LK T++ L +
Sbjct: 1612 EVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKD-LKRTKALLADAQL 1670
Query: 586 RRDEMLGLVPMRQSIIDLK----EKEIP-----ELRNKLQNVNRDIQRLKNDIEEQETLL 636
D + P ++ I LK E E + R ++ D+ +DI + +T L
Sbjct: 1671 MLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTAL 1730
Query: 637 GTIMPEEESAKVCLTDVTIMERFQMELKDVER-------KIAQQAAKLQGI-DLDRTVQQ 688
EE+ +++ I R + + +D+ +AQ + L I DL +++
Sbjct: 1731 -----EEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEE 1785
Query: 689 VNQEKQEKQHKLDTVSSKIE------LNRKLIQDQQEQIQHL-------KSTTNELKSEK 735
N+EKQE Q KL + S++E +++ L+ Q+ +I+ L ++ L+S
Sbjct: 1786 ANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLA 1845
Query: 736 LQISTNLQRRQQLEEQTVELST----EVQSLYREIKDAKEQVSPLETTLEKFQQEKEELI 791
++ N+++ + +Q + + + L R+++D KE++ L + ++K EL
Sbjct: 1846 SRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELE 1905
Query: 792 NKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSEC 851
+ Q D+K K I IE+ ++ + E +N + +++
Sbjct: 1906 MDLESLEAANQSLQADLKLAFKRIGDLQAAIEDEME------SDENEDLINSLQDMVTKY 1959
Query: 852 EKHKEKINEDMRLMRQDIDTQKIQERWLQDN 882
+K K K+ D + + D + WL N
Sbjct: 1960 QKRKNKLEGDSDVDSELEDRVDGVKSWLSKN 1990
Score = 82.8 bits (203), Expect = 2e-15
Identities = 134/764 (17%), Positives = 312/764 (40%), Gaps = 96/764 (12%)
Query: 21 EDSNWPLSEGKALKQKFDEIFSATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEK 80
++ N S + L + E A + +K L+T + Q + ++ ME + ++ +
Sbjct: 1300 DERNTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEIN 1359
Query: 81 ACEIRDQITSKEAQLT----------SSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLD 130
E+ D E +L + K + + +E++L+ + +++E L +
Sbjct: 1360 G-EVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADS 1418
Query: 131 NEI-KALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRE 189
E +AL KK+ ++ +EL++ + +Q+ + H ++ R + +L H E
Sbjct: 1419 EESQRALQQLKKKCQRLTAELQDTKLHL---EGQQVRN--HELEKKQRRFDSELSQAHEE 1473
Query: 190 LEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPF 249
++ + L +EK LL E L+ Q + I + SL +L+ +
Sbjct: 1474 AQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQ----DISSQ 1529
Query: 250 SERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSE 309
+ + K+ ++ ++ EAK +Q + T++ + ++R + + R+ + S+
Sbjct: 1530 ESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLR-LEMEMERMRQTHSK 1588
Query: 310 ILSKKQNELKNVKY----ELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEV 365
+ + E++ + +L+Q+E + E Q++++ +REL + + + +
Sbjct: 1589 EMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDF 1648
Query: 366 ISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELT 425
S + + DL RT L L+H K+ A +I ++K++ +
Sbjct: 1649 ESEKRLRKDLKRTKALLADAQLMLDH-----------LKNSAPSKREIAQLKNQLEESEF 1697
Query: 426 SLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSS 485
+ +K +E + +I+ L ++L+ ++ KN I N L+ +E
Sbjct: 1698 TCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQE---- 1753
Query: 486 YEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVC 545
D + + K + ++S+ A + A QL + N+
Sbjct: 1754 ------------DMNELMKKHKAAVAQASRDLAQINDLQA-------QLEEANKE----- 1789
Query: 546 QRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKE 605
+ ELQE + LQS++ + +++ K R+ ++ ++ +
Sbjct: 1790 ------KQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRE--------LETRLEFER 1835
Query: 606 KEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKD 665
++ L + + ++++L EE++ + E+E K R Q +L+D
Sbjct: 1836 TQVKRLESLASRLKENMEKL---TEERDQRIAAENREKEQNK----------RLQRQLRD 1882
Query: 666 VERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQ-HL 724
+ ++ + A K + R ++ + + + ++ + ++L K I D Q I+ +
Sbjct: 1883 TKEEMGELARK--EAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIEDEM 1940
Query: 725 KSTTNELKSEKLQ-ISTNLQRRQQLEEQTVELSTEVQSLYREIK 767
+S NE LQ + T Q+R+ E ++ +E++ +K
Sbjct: 1941 ESDENEDLINSLQDMVTKYQKRKNKLEGDSDVDSELEDRVDGVK 1984
Score = 68.6 bits (166), Expect = 3e-11
Identities = 134/642 (20%), Positives = 255/642 (39%), Gaps = 139/642 (21%)
Query: 498 DFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVF---QTEAE 554
+F D L + K + ++ + + L E SCC RVF T A
Sbjct: 1120 EFRRRFDVLAPHLTKKHGRNYIVVDERRAVEELLECLDLEKSSCCMGLSRVFFRAGTLAR 1179
Query: 555 LQEVISDLQS--------------------KLRLAPDKLKSTESELKKKEKRRD------ 588
L+E + S K ++ ++ + +KK + +D
Sbjct: 1180 LEEQRDEQTSRNLTLFQAACRGYLARQHFKKRKIQDLAIRCVQKNIKKNKGVKDWPWWKL 1239
Query: 589 ----EMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPE-- 642
L V + + I K++EI +LR+KL+ ++ L+ + + E+ + + E
Sbjct: 1240 FTTVRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELT 1299
Query: 643 -----EESAKVCLTDVTIMERF------------------QMELKDVERKIAQ--QAAKL 677
ESA L D ER QME+ ++E A+ +AA++
Sbjct: 1300 DERNTGESASQ-LLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEI 1358
Query: 678 QG------------IDLDRTVQQVNQEK----QEKQHKLDT-VSSKIELNRKL------I 714
G + +R V++V+ K QE + KL+ +K +L R+L
Sbjct: 1359 NGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADS 1418
Query: 715 QDQQEQIQHLKS----TTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAK 770
++ Q +Q LK T EL+ KL + R +LE++ +E+ + E + K
Sbjct: 1419 EESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREK 1478
Query: 771 EQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDI---KEKVKNIHGYMKDIENYIQ 827
Q EK Q+EK+ L+ + + + ++K DI +KV ++ ++DI + Q
Sbjct: 1479 LQ-------REKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISS--Q 1529
Query: 828 DGKDDYK---------------KQKETELNKVIAQLSECEKHKEKINEDMRLMRQ----- 867
+ KD+ K +E EL++ + E+ K ++ +M MRQ
Sbjct: 1530 ESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKE 1589
Query: 868 -DIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQM---------QVLQMKSE 917
+ ++++E L++ +L+E E++++ L+E ++ QV + E
Sbjct: 1590 MESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFE 1649
Query: 918 HQK-LEENIDNIK---RNHNLALGRQKG---YEEEIIHFKKELREPQF--RDAEEKYREM 968
+K L +++ K + L L K + EI K +L E +F A + + M
Sbjct: 1650 SEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAM 1709
Query: 969 MIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIRD 1010
+ + L D+ L++ + + K E N++ D
Sbjct: 1710 EVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEED 1751
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 128 bits (322), Expect = 3e-29
Identities = 195/1007 (19%), Positives = 428/1007 (42%), Gaps = 152/1007 (15%)
Query: 76 QYKEKACEIRDQITSKE---AQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNE 132
Q + K E+ +++ +E A+LT+ K + E+E LK + ++E L+K+ K E
Sbjct: 916 QLEAKVKEMNERLEDEEEMNAELTAKK---RKLEDECSELKKDIDDLELTLAKVEK---E 969
Query: 133 IKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEK 192
A +++ K + ++ + L+E + K+ ++ L HQ+ L D E +K
Sbjct: 970 KHATENKVKNLTEEMAGLDEIIAKL----TKEKKALQEAHQQA-------LDDLQVEEDK 1018
Query: 193 LNKESR---LLNQEKSEL---LVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFER 246
+N S+ L Q+ +L L ++ ++++ +R + + L Q LE D +
Sbjct: 1019 VNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQ- 1077
Query: 247 GPFSERQIKNFHKLVRERQ---EGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRI 303
E ++K + ++ E E A QL E + ++ +E+ ++T ++
Sbjct: 1078 ---LEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKV 1134
Query: 304 IELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKM 363
+L+S++ EL+ + L++ G++ +E+++ K E E K ++ TL+
Sbjct: 1135 EKLRSDL----SRELEEISERLEEAGGATSVQIEMNK---KREAEFQKMRRDLEEATLQH 1187
Query: 364 E--VISLQNEKAD-----------LDRTLRKLDQEMEQLNHHTTTRT-QMEMLTKDKADK 409
E +L+ + AD L R +KL++E + T ME + K KA+
Sbjct: 1188 EATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANL 1247
Query: 410 DEQIRKIKSRHSDELTSLLGYFPNKKQLEDW------LHSKSKEINQTRDRLAKLNKELA 463
++ R ++ + ++ L ++ L D+ L +++ E+ + + L +L
Sbjct: 1248 EKVSRTLEDQANEYRVKL---EEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLT 1304
Query: 464 SSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDL--DRLKEEIEKSSKQRAMLA 521
+ + +LKR+ E+ ++ L S + DL ++ +EE E ++ + +L+
Sbjct: 1305 RGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLS 1364
Query: 522 GATAVYSQFIT-------QLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLK 574
A + +Q+ T Q T+E + + Q E E ++ S L +L+
Sbjct: 1365 KANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQ 1424
Query: 575 STESELKKKEKRRDEMLGLVPMRQSIIDL-----------KEKEIPELRNKLQNVNRDIQ 623
+ +L +R + + +Q D + E+ + + ++++ ++
Sbjct: 1425 NEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELF 1484
Query: 624 RLKNDIEEQETLLGTIMPEEESAKVCLTDVTIM----ERFQMELKDVERKIAQQAAKLQG 679
+LKN EE L T E ++ + ++D+T + EL+ V +++ + +LQ
Sbjct: 1485 KLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQS 1544
Query: 680 IDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQIS 739
+ ++E + + +L+ K E+ RKL + +E Q ++ + S + +
Sbjct: 1545 ALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLD 1604
Query: 740 TNLQRRQQ-----------LEEQTVELS----------TEVQSLYREIKDA--------- 769
+ R + L E ++LS +V+SL +KD
Sbjct: 1605 AETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVR 1664
Query: 770 -----KEQVSPLETTLEKFQQEKEEL---INKKNTSNKIAQDKLNDIKEKVKNIHGYMKD 821
KE ++ +E Q E EEL + + S K+A+ +L + E+V+ +H
Sbjct: 1665 ANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTS 1724
Query: 822 IENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQD 881
+ N + + D Q ++E+ + + + E+ +K D +M +++ ++
Sbjct: 1725 LINQKKKMESDL-TQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQ------DT 1777
Query: 882 NLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNI--------KRNHN 933
+ L + + +++ ++ + L E Q+ + K + QKLE + + KRN
Sbjct: 1778 SAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAE 1837
Query: 934 LALGRQKGYEEEIIHFKKELREPQFRDAEEKYREMMIVMRTTELVNK 980
G +K ++ ++E ++ E+K ++R +LV+K
Sbjct: 1838 SVKGMRKS--------ERRIKELTYQTEEDKKN----LLRLQDLVDK 1872
Score = 121 bits (304), Expect = 3e-27
Identities = 193/1051 (18%), Positives = 435/1051 (41%), Gaps = 200/1051 (19%)
Query: 65 KEYQMELKYLKQYKEKAC-EIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNL 123
+E EL K+ E C E++ I E L ++ + EN++ L + ++ +
Sbjct: 932 EEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEII 991
Query: 124 SKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGT---DEQLNDLYHNHQRTVREKE 180
+K+ K E KAL +Q D E+K+ + + ++Q++DL + ++ +++
Sbjct: 992 AKLTK---EKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDL----EGSLEQEK 1044
Query: 181 RKLVDCHRELEKLNKESRLLNQ-----EKSELLVEQGRLQLQADRHQEHIRARDSLIQSL 235
+ +D R KL + +L + E +L +E+ + + D +Q++ + D + +L
Sbjct: 1045 KVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLAL 1104
Query: 236 ATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRD 295
Q +L ++ +I+ + + + AK +L +D + ++++EI +
Sbjct: 1105 QLQKKLKE------NQARIEELEEELEAERTARAKV-EKLRSDLS-------RELEEISE 1150
Query: 296 KKTGLGRIIELKSEILSKKQNELKNVKYELQQL------------EGSSDRILELDQELI 343
+ G ++ E+ K++ E + ++ +L++ + +D + EL +++
Sbjct: 1151 RLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQID 1210
Query: 344 KAERELSKAEKNSNVETLKMEVISLQNE-----KADLDRTLR-----------KLDQEME 387
+R K EK + L+++ ++ E KA+L++ R KL++
Sbjct: 1211 NLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQR 1270
Query: 388 QLNHHTTTRTQMEM----LTKDKADKD---EQIRKIKSRHSDELTSLLGYFPNKKQLEDW 440
LN TT R +++ L + +K+ Q+ + K ++ ++ L K+QLE+
Sbjct: 1271 SLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDL------KRQLEEE 1324
Query: 441 LHSKSK---EINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQ 497
+K+ + R L ++ + K + L + +++ + K
Sbjct: 1325 GKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTK-------- 1376
Query: 498 DFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQE 557
+E+D + EE+E++ K+ A Q + + ++ C + +T+ LQ
Sbjct: 1377 -YETDAIQRTEELEEAKKKLA----------QRLQDAEEAVEAVNAKCSSLEKTKHRLQN 1425
Query: 558 VISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQN 617
I DL + ++ + + L KK++ D++L + + + E+ + + ++
Sbjct: 1426 EIEDLMVDV----ERSNAAAAALDKKQRNFDKILAEWKQKY---EESQSELESSQKEARS 1478
Query: 618 VNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIM----ERFQMELKDVERKIAQQ 673
++ ++ +LKN EE L T E ++ + ++D+T + EL+ V +++ +
Sbjct: 1479 LSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVE 1538
Query: 674 AAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKS 733
+LQ + ++E + + +L+ K E+ RKL + +E Q ++ + S
Sbjct: 1539 KLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDS 1598
Query: 734 EKLQISTNLQRRQQ-----------LEEQTVELS----------TEVQSLYREIKDA--- 769
+ + + R + L E ++LS +V+SL +KD
Sbjct: 1599 LQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQ 1658
Query: 770 -----------KEQVSPLETTLEKFQQEKEEL---INKKNTSNKIAQDKLNDIKEKVKNI 815
KE ++ +E Q E EEL + + S K+A+ +L + E+V+ +
Sbjct: 1659 LDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLL 1718
Query: 816 HGY------------------MKDIENYIQDGKDDYKKQKET---------ELNKVIAQL 848
H ++E +Q+ ++ +K K+ EL K
Sbjct: 1719 HSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTS 1778
Query: 849 SECEKHKEKINEDMRLMRQDIDT-------------QKI--------------QERWLQD 881
+ E+ K+ + + ++ ++ +D QK+ Q+R +
Sbjct: 1779 AHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAES 1838
Query: 882 NLTLRKRNEELKEV----EEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALG 937
+RK +KE+ EE++K L+ + LQ+K + K + + N NL+
Sbjct: 1839 VKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKF 1898
Query: 938 RQKGYEEEIIHFKKELREPQFRDAEEKYREM 968
R+ +E + + ++ E Q K R++
Sbjct: 1899 RKVQHELDEAEERADIAESQVNKLRAKSRDI 1929
Score = 119 bits (297), Expect = 2e-26
Identities = 186/880 (21%), Positives = 372/880 (42%), Gaps = 143/880 (16%)
Query: 190 LEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIR-ARDSLIQSLATQLELDGFERGP 248
LEK + L ++ LL E+ LQLQ Q+++ A + Q + +++L
Sbjct: 865 LEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQL------- 917
Query: 249 FSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKS 308
E ++K ++ + + +E MN AE K+K DE + K + + +
Sbjct: 918 --EAKVKEMNERLEDEEE---------MN--AELTAKKRKLEDECSELKKDIDDLELTLA 964
Query: 309 EILSKK---QNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEV 365
++ +K +N++KN+ E+ L+ E+ +L K ++ L +A + + ++ L++E
Sbjct: 965 KVEKEKHATENKVKNLTEEMAGLD-------EIIAKLTKEKKALQEAHQQA-LDDLQVE- 1015
Query: 366 ISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELT 425
+++ L ++ KL+Q+++ L +E K + D + RK++
Sbjct: 1016 ---EDKVNSLSKSKVKLEQQVDDL------EGSLEQEKKVRMDLERAKRKLEGDLKLTQE 1066
Query: 426 SLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSS 485
S++ +K QLE+ L K +INQ +K+ E + Q + + R EE
Sbjct: 1067 SIMDLENDKLQLEEKLKKKEFDINQQN---SKIEDEQVLALQLQKKLKENQARIEELEEE 1123
Query: 486 YEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVC 545
E + + SDL R E+E+ S++ GAT+V +
Sbjct: 1124 LEAERTARAKVEKLRSDLSR---ELEEISERLEEAGGATSVQIEMNK------------- 1167
Query: 546 QRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLG-LVPMRQSIIDLK 604
+ EAE Q++ DL+ A + ++T + L+KK LG + Q +
Sbjct: 1168 ----KREAEFQKMRRDLEE----ATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKL 1219
Query: 605 EKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEE-------ESAKVCLTDVTIME 657
EKE E + +L +V +++++ E + T+ + E A+ L D T
Sbjct: 1220 EKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQR 1279
Query: 658 -RFQMELKDVERKIAQQAAKLQGI------------DLDRTVQQVNQEKQEKQHKLDTVS 704
+ Q E ++ R++ ++ A + + DL R +++ + K H L +
Sbjct: 1280 AKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSAR 1339
Query: 705 SKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTN-----LQRRQQLEEQTVELSTEV 759
+L R+ +++ E L+ ++ SE Q T +QR ++LEE +L+ +
Sbjct: 1340 HDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1399
Query: 760 QSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYM 819
Q ++ + S LE T + Q E E+L+ SN A + +K +N +
Sbjct: 1400 QDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAA----ALDKKQRNFDKIL 1455
Query: 820 KDIENYIQDGKDDYK-KQKE-----TELNKVIAQLSECEKHKEKINEDMRLMRQDI---- 869
+ + ++ + + + QKE TEL K+ E +H E + + ++++I
Sbjct: 1456 AEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLT 1515
Query: 870 -----------DTQKIQERWLQDNLTLRKRNEELK-EVEEERKQHLKEMGQMQVLQMKSE 917
+ +K++++ + L L+ EE + +E E + L+ Q++ Q+K+E
Sbjct: 1516 EQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILR--AQLEFNQIKAE 1573
Query: 918 HQK----LEENIDNIKRNH-------NLALGRQKGYEEEIIHFKKELR------EPQFRD 960
++ +E ++ KRNH +L + E++ KK++ E Q
Sbjct: 1574 IERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSH 1633
Query: 961 AEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMK 1000
A E +++ + + KD I LD A+ +K
Sbjct: 1634 ANRMAAEAQKQVKSLQSLLKDTQI---QLDDAVRANDDLK 1670
Score = 107 bits (267), Expect = 7e-23
Identities = 174/898 (19%), Positives = 375/898 (41%), Gaps = 96/898 (10%)
Query: 60 QGQKVKEYQ-MELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVK---SYENELDPLKNR 115
Q K+++ Q + L+ K+ KE I + EA+ T+ ++ K EL+ + R
Sbjct: 1092 QNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISER 1151
Query: 116 LKE--------IEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLND 167
L+E IE N + + + L+ Q E + L +K EQ+++
Sbjct: 1152 LEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDN 1211
Query: 168 LYHNHQRTVREK-ERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIR 226
L Q+ +EK E KL EL+ + + + K+ L L+ QA+ ++ +
Sbjct: 1212 LQRVKQKLEKEKSEFKL-----ELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLE 1266
Query: 227 ARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLK 286
+ TQ E G + RQ++ L+ + G+ Q+ E LK
Sbjct: 1267 EAQRSLNDFTTQRAKLQTENGELA-RQLEEKEALISQLTRGKLSYTQQM-------EDLK 1318
Query: 287 QKQIDEIRDKKTGLGRIIELKS---EILSKKQNELKNVKYELQQLEGSSDRIL-----EL 338
+Q++E K L ++ ++L ++ E K ELQ++ ++ + +
Sbjct: 1319 -RQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKY 1377
Query: 339 DQELIKAERELSKAEKN--SNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTR 396
+ + I+ EL +A+K ++ + V ++ + + L++T +L E+E L
Sbjct: 1378 ETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDL------- 1430
Query: 397 TQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLA 456
M+ ++++ K R+ D++ L + ++ + L S KE L
Sbjct: 1431 ----MVDVERSNAAAAALDKKQRNFDKI--LAEWKQKYEESQSELESSQKEARSLSTELF 1484
Query: 457 KLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQ 516
KL S ++ E K +E++S ++L + G E + R + E+EK Q
Sbjct: 1485 KLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEG-GKNVHELEKVRKQLEVEKLELQ 1543
Query: 517 RAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDK---- 572
A+ + L E Q +AE++ +++ ++ A
Sbjct: 1544 SAL--------EEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRV 1595
Query: 573 LKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQ 632
+ S ++ L + + R+E+L + + DL E EI +L + NR + ++
Sbjct: 1596 VDSLQTSLDAETRSRNEVLRVKKKMEG--DLNEMEI-----QLSHANRMAAEAQKQVKSL 1648
Query: 633 ETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQE 692
++LL + + A V + + + VER+ A+L+ +L V+Q +
Sbjct: 1649 QSLLKDTQIQLDDA------VRANDDLKENIAIVERRNNLLQAELE--ELRAVVEQTERS 1700
Query: 693 KQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQT 752
++ + +L S +++L Q + ++S +L+SE + +Q + EE+
Sbjct: 1701 RKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSE---VEEAVQECRNAEEKA 1757
Query: 753 VELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIA----QDKLNDI 808
+ T+ + E+K ++ + LE + +Q ++L ++ + + +IA + +L +
Sbjct: 1758 KKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKL 1817
Query: 809 KEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQD 868
+ +V+ + G ++ + + +K E + ++ Q E +K+ ++ + + ++
Sbjct: 1818 EARVRELEGELEAEQKRNAESVKGMRK-SERRIKELTYQTEEDKKNLLRLQDLVDKLQLK 1876
Query: 869 IDTQKIQ----ERWLQDNLT-LRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKL 921
+ K Q E NL+ RK EL E EE ++ + QV +++++ + +
Sbjct: 1877 VKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEER-----ADIAESQVNKLRAKSRDI 1929
Score = 97.1 bits (240), Expect = 9e-20
Identities = 158/792 (19%), Positives = 317/792 (40%), Gaps = 105/792 (13%)
Query: 338 LDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRT 397
+ +E + + L K+E + L+ +++SL EK DL ++ E + LN
Sbjct: 854 MKEEFGRIKETLEKSEARR--KELEEKMVSLLQEKNDLQL---QVQAEQDNLND---AEE 905
Query: 398 QMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAK 457
+ + L K+K + +++++ R DE K++LED K+I+ LAK
Sbjct: 906 RCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAK 965
Query: 458 LNKELASSEQNKNHINNELKRKEEQLS--SYEDKLFDVCGSQDFESDLDRLKEEIEKSSK 515
+ KE ++E ++ E+ +E ++ + E K Q + DL ++++ SK
Sbjct: 966 VEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALD-DLQVEEDKVNSLSK 1024
Query: 516 QRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAEL---QEVISDLQSKLRLAPDK 572
+ L L E + + + + E +L QE I DL++ +K
Sbjct: 1025 SKVKLEQQV---DDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEK 1081
Query: 573 LKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQ---NVNRDIQRLKNDI 629
LK E ++ ++ + ++ L Q + + I EL +L+ +++L++D+
Sbjct: 1082 LKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDL 1141
Query: 630 EEQETLLGTIMPEEESAKVCLTDVTIME--RFQMELKDVE--------------RKIAQQ 673
+ + + E A ++ FQ +D+E +K A
Sbjct: 1142 SRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADS 1201
Query: 674 AAKL--QGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNE- 730
A+L Q +L R Q++ +EK E + +LD V+S +E K + ++ + L+ NE
Sbjct: 1202 VAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEY 1261
Query: 731 -LKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEE 789
+K E+ Q S N Q +L TE L R++++ + +S L + Q+ E+
Sbjct: 1262 RVKLEEAQRSLN-----DFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMED 1316
Query: 790 LINKKNTSNK-----------------IAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDD 832
L + K + +++ + E + + + + +
Sbjct: 1317 LKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTK 1376
Query: 833 YK-------KQKETELNKVIAQLSECEKHKEKINEDM--------RLMRQDIDTQKIQER 877
Y+ ++ E K+ +L + E+ E +N RL + D ER
Sbjct: 1377 YETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVER 1436
Query: 878 WLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALG 937
L K+ ++ E KQ +E Q ++ + E + L + +K
Sbjct: 1437 SNAAAAALDKKQRNFDKILAEWKQKYEE-SQSELESSQKEARSLSTELFKLK-------- 1487
Query: 938 RQKGYEEEIIH---FKKELR--EPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQA 992
YEE + H FK+E + + + D E+ E + E V K L++ L A
Sbjct: 1488 --NAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSA 1545
Query: 993 IMKFHSMKMEEINKIIRDLWRSTYRGQDIEYIEIRSDADENVSASD---KRRNYNYRVVM 1049
+ + + E KI+R +E+ +I+++ + ++ D ++ N++ V+
Sbjct: 1546 LEEAEASLEHEEGKILR---------AQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVV 1596
Query: 1050 LKGDTALDMRGR 1061
T+LD R
Sbjct: 1597 DSLQTSLDAETR 1608
Score = 78.2 bits (191), Expect = 4e-14
Identities = 118/576 (20%), Positives = 257/576 (44%), Gaps = 84/576 (14%)
Query: 456 AKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQD-----FESDLDRLKEEI 510
A+ KE+A+ ++ I L++ E + E+K+ + ++ +++ D L +
Sbjct: 845 AETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAE 904
Query: 511 EKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTE---AELQEVISDLQSKLR 567
E+ + A + +L DE + + + + E +EL++ I DL+ L
Sbjct: 905 ERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLA 964
Query: 568 LAPDKLKSTESELKKKEKRR---DEMLG-LVPMRQSIIDLKEKEIPELRNKLQNVNRDIQ 623
+ +TE+++K + DE++ L ++++ + ++ + +L+ + VN +
Sbjct: 965 KVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVN-SLS 1023
Query: 624 RLKNDIEEQ-ETLLGTIMPEE------ESAK------VCLTDVTIM----ERFQME--LK 664
+ K +E+Q + L G++ E+ E AK + LT +IM ++ Q+E LK
Sbjct: 1024 KSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLK 1083
Query: 665 DVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNR-------KLIQDQ 717
E I QQ +K++ D Q+ ++ +E Q +++ + ++E R KL D
Sbjct: 1084 KKEFDINQQNSKIE--DEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDL 1141
Query: 718 QEQIQHLKSTTNEL-KSEKLQISTNLQR-------RQQLEEQTVELSTEVQSLYRE---- 765
+++ + E + +QI N +R R+ LEE T++ +L ++
Sbjct: 1142 SRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADS 1201
Query: 766 IKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENY 825
+ + EQ+ L+ +K ++EK E K+ D + E++ ++ +
Sbjct: 1202 VAELGEQIDNLQRVKQKLEKEKSEF--------KLELDDVTSNMEQIIKAKANLEKVSRT 1253
Query: 826 IQDGKDDYKKQKETELNKVIAQLSECEKHKEKI-NEDMRLMRQDIDTQKIQERWLQDNLT 884
++D ++Y+ +L + L++ + K+ E+ L RQ + + + + + L+
Sbjct: 1254 LEDQANEYR----VKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLS 1309
Query: 885 LRKRNEELK-EVEEERK-----QHLKEMGQMQVLQMKSEHQKLEENIDNIKR-----NHN 933
++ E+LK ++EEE K H + + ++ ++++ E ++R N
Sbjct: 1310 YTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSE 1369
Query: 934 LALGRQKGYEEEIIHFKKELRE------PQFRDAEE 963
+A R K YE + I +EL E + +DAEE
Sbjct: 1370 VAQWRTK-YETDAIQRTEELEEAKKKLAQRLQDAEE 1404
Score = 67.8 bits (164), Expect = 6e-11
Identities = 102/497 (20%), Positives = 216/497 (43%), Gaps = 70/497 (14%)
Query: 34 KQKFDEIFSATRYIKALETLRQVRQTQGQKVKE-YQMELKYLKQYKEKACEIRDQITSKE 92
KQK++E S +++ + + T+ K+K Y+ L++L+ +K + ++++I+
Sbjct: 1459 KQKYEESQSE---LESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLT 1515
Query: 93 AQLTSS-------KEIVKSYENELDPLKNRLKE----IEHNLSKIMKLDNEIKALDSRKK 141
QL +++ K E E L++ L+E +EH KI++ E +
Sbjct: 1516 EQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQI----- 1570
Query: 142 QMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLN 201
+E+E K+ + DE++ NHQR V + L R ++ + + +
Sbjct: 1571 -----KAEIERKLAE----KDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKME 1621
Query: 202 QEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLV 261
+ +E+ ++ A Q+ +++ SL++ TQ++LD R + +K +V
Sbjct: 1622 GDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKD--TQIQLDDAVR---ANDDLKENIAIV 1676
Query: 262 RERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIEL--KSEILSKKQNELK 319
R N L+ AE E L+ R +K +IE + ++L + L
Sbjct: 1677 ERR--------NNLLQ--AELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLI 1726
Query: 320 NVKYELQ-QLEGSSDRILELDQELIKAERELSKAEKNSNV--ETLKMEVISLQNEKADLD 376
N K +++ L + E QE AE + KA ++ + E LK E Q+ A L+
Sbjct: 1727 NQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKE----QDTSAHLE 1782
Query: 377 RTLRKLDQEMEQLNHHTTTRTQM------EMLTKDKADKDEQIRKIKSRHSDELTSLLGY 430
R + ++Q ++ L H Q+ + L K +A E ++++ S+ G
Sbjct: 1783 RMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGM 1842
Query: 431 FPNKKQLEDWLH---SKSKEINQTRDRLAKL-------NKELASSEQNKNHINNELKRKE 480
+++++++ + K + + +D + KL ++ +E+ N ++ ++ +
Sbjct: 1843 RKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQ 1902
Query: 481 EQLSSYEDKLFDVCGSQ 497
+L E++ D+ SQ
Sbjct: 1903 HELDEAEERA-DIAESQ 1918
Score = 45.4 bits (106), Expect = 3e-04
Identities = 66/357 (18%), Positives = 160/357 (44%), Gaps = 52/357 (14%)
Query: 706 KIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTV-------ELSTE 758
K+ K + E + + + E K + + RR++LEE+ V +L +
Sbjct: 833 KLYFKIKPLLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQ 892
Query: 759 VQSLYREIKDAKEQVS-------PLETTLEKFQQ--EKEELINKKNTSNK-IAQDKLNDI 808
VQ+ + DA+E+ LE +++ + E EE +N + T+ K +D+ +++
Sbjct: 893 VQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSEL 952
Query: 809 KEKVKNIHGYMKDI--ENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMR 866
K+ + ++ + + E + + K ++ L+++IA+L+ K K+ + E +
Sbjct: 953 KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLT---KEKKALQEAHQQAL 1009
Query: 867 QDIDTQKIQERWL-QDNLTLRKRNEELK-EVEEERKQHLK------------EMGQMQVL 912
D+ ++ + L + + L ++ ++L+ +E+E+K + ++ Q ++
Sbjct: 1010 DDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIM 1069
Query: 913 QMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEI--IHFKKELREPQFR--DAEEKYREM 968
++++ +LEE + K+ ++ K +E++ + +K+L+E Q R + EE+
Sbjct: 1070 DLENDKLQLEEKLK--KKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAE 1127
Query: 969 MIVMRTTELVNKDLDIYYKTLDQAI----------MKFHSMKMEEINKIIRDLWRST 1015
E + DL + + + + ++ + + E K+ RDL +T
Sbjct: 1128 RTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEAT 1184
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 127 bits (320), Expect = 5e-29
Identities = 218/1057 (20%), Positives = 440/1057 (41%), Gaps = 132/1057 (12%)
Query: 92 EAQLTSSKEIVKSYENEL---DPLKN-RLKEIEHNLSKIMKLDNEIKA-LD--SRKKQME 144
+A L +EI ++Y+ E + ++N +L++++ ++ + + +I LD S++ +M
Sbjct: 669 KAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEML 728
Query: 145 KDNSE--------LEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKE 196
+DN E L E+ +K+ T +Q + + + +R KL E L KE
Sbjct: 729 QDNVEGYRREITSLHERNQKLTATTQKQ-EQIINTMTQDLRGANEKLAVAEVRAENLKKE 787
Query: 197 SRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKN 256
+L + SE+ + Q R L A++ +++ + +Q++ LE E +R
Sbjct: 788 KEML--KLSEVRLSQQRESLLAEQRGQNLLLTN--LQTIQGILERSETET---KQRLSSQ 840
Query: 257 FHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQN 316
KL E + K N++ L + +D R T + K E+L Q
Sbjct: 841 IEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTK-ELLKNAQK 899
Query: 317 ELKNVKYELQQLE----------------GSSDRILELDQELIKAERELSKAEKN----- 355
E+ +K L +E + + + +L +L + E +++ ++
Sbjct: 900 EIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTST 959
Query: 356 SNVETLKMEVISLQNEKADLDRTLRKLDQEME-QLNHHTTTRTQMEMLTKDKADKDEQIR 414
SNVE + V SL+ + ++ + +E +L +TQ+E + + ++++
Sbjct: 960 SNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQ 1019
Query: 415 KIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINN 474
K R + + ++QL + + S N+ ++ L + + L++ +Q +
Sbjct: 1020 DDKRRAIESM---------EQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQE 1070
Query: 475 ELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGAT---------- 524
+ K E + YE +L + + D E+ L KE++ K + R L T
Sbjct: 1071 QAKIAVEAQNKYEREL--MLHAADVEA-LQAAKEQVSKMASVRQHLEETTQKAESQLLEC 1127
Query: 525 -AVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDK-----LKSTES 578
A + + L DE C C+ + + L + I L K+ + + L + S
Sbjct: 1128 KASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLS 1187
Query: 579 ELKKKEKRRDEMLGLVPMRQSIIDLK----EKEIPELRNKLQNVNRDIQRLKNDI----E 630
E K +++ E+L + + I + + + E R +++ + R++Q L++ + E
Sbjct: 1188 EEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAERE 1247
Query: 631 EQETLLGTIMPEEESAKVCLTDVTIMERFQM---ELKDVERKIAQQAAKLQGIDLD-RTV 686
+ + T+ EE K T +ME +M E + +E+ + Q AK++ ++LD +
Sbjct: 1248 KVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPL 1307
Query: 687 QQVNQEKQEKQHKLDTVSSKIE--LNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQR 744
Q+ N E EK L +E + R ++Q Q T E + + + +R
Sbjct: 1308 QEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKR 1367
Query: 745 RQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDK 804
QQL E+ L E+ + + + + L+ L K + EKE T K K
Sbjct: 1368 IQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKE-------TIQKDLDAK 1420
Query: 805 LNDIKEKVKNIHGYMKDIENYIQDGKDDYK--KQKETELNKVIAQLSECEKHKEKINEDM 862
+ DI+EKVK I K Y K Y+ K ++ ++ + AQ S + + ++M
Sbjct: 1421 IIDIQEKVKTITQVKKIGRRY----KTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEM 1476
Query: 863 RLMRQDIDTQKIQERWLQDNL-----TLRKRNEELKEVEEERKQHLKEMGQM-QVLQMK- 915
+ +++ ++ + + + L+ + TL ++ E + ++E+ Q E+ ++ Q LQ +
Sbjct: 1477 QELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRT 1536
Query: 916 SEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKYREMMIVMRTT 975
++ ++L + I + A+ K + K +L + + E K R
Sbjct: 1537 TQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTK---ENEELKQR--------- 1584
Query: 976 ELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQDIEYIEIRSDADENVS 1035
N LD LD I S I+++ R+L R ++E R + E +
Sbjct: 1585 ---NGALDQQKDELDVRITALKSQYEGRISRLEREL-----REHQERHLEQRDEPQEPSN 1636
Query: 1036 ASDKRRNYNYRVVMLKGDTALDMRGRCSAGQKVLASL 1072
+++ R + LK A RG S A++
Sbjct: 1637 KVPEQQ----RQITLKTTPASGERGIASTSDPPTANI 1669
Score = 124 bits (311), Expect = 5e-28
Identities = 247/1263 (19%), Positives = 517/1263 (40%), Gaps = 222/1263 (17%)
Query: 33 LKQKFDEIFSATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKE 92
L+ K +E+ + L+T + Q K + L LK+ KE+ + ++ ++
Sbjct: 226 LENKKEEVSRLEEQMNGLKTSNEHLQ------KHVEDLLTKLKEAKEQQASMEEKFHNEL 279
Query: 93 AQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMK--------LDNEIKALDSRKKQME 144
+ KS ++ + N L L K++K + + + ++ K QME
Sbjct: 280 NAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQME 339
Query: 145 KDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEK 204
K+ E ++EK + ++ L+ E+ + + K+ K L +
Sbjct: 340 KEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELY 399
Query: 205 SELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQ---------IK 255
+ + Q +L L+ ++ + D +++ + + + +R + Q ++
Sbjct: 400 NAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLE 459
Query: 256 NFHKLVRERQEGEAKTANQ-------------LMNDFAEKETLKQKQIDE------IRDK 296
K ++ QE K Q + D +++ + +++E IRD+
Sbjct: 460 QAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDE 519
Query: 297 KTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNS 356
+ I SE++S+ +N++ ELQQ +Q L+ A REL + +
Sbjct: 520 EVS-SADISSSSEVISQHLVSYRNIE-ELQQ----------QNQRLLVALRELGETRERE 567
Query: 357 NVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKI 416
ET ++ LQ L+ L +L+Q + H QM+++ +D R +
Sbjct: 568 EQETTSSKITELQ---LKLESALTELEQLRKSRQH------QMQLVDSIVRQRD-MYRIL 617
Query: 417 KSR--------HSDELTSL-LGYFPNKKQLEDWLHS-------KSKEINQTRDRLAKLNK 460
S+ H+ L + L P + + + +S E + + L +L +
Sbjct: 618 LSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQE 677
Query: 461 ELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAML 520
+ ++ K NE K + EQL ++++ D S ++ +++ +SK+ ML
Sbjct: 678 IFENYKKEK--AENE-KIQNEQLEKLQEQV------TDLRSQNTKISTQLDFASKRYEML 728
Query: 521 AGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTE--S 578
Y + IT L + N Q++ T + +++I+ + LR A +KL E +
Sbjct: 729 QDNVEGYRREITSLHERN-------QKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRA 781
Query: 579 ELKKKEKRRDEMLGLVPMR-------------------------QSIIDLKEKEIPE-LR 612
E KKEK EML L +R Q I++ E E + L
Sbjct: 782 ENLKKEK---EMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLS 838
Query: 613 NKLQNVNRDIQRLK----NDIEEQET--------LLGTIMPEEESAKVCLTDVTIMERFQ 660
++++ + +I LK N++E++ T LL T + + L +++ Q
Sbjct: 839 SQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQ 898
Query: 661 ME-------LKDVERKIAQQAAKLQG-------IDLDRTVQQVNQEKQ---EKQHKLDTV 703
E L ++E ++A Q+++ G D+D V Q+ Q ++ + + +L T
Sbjct: 899 KEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTS 958
Query: 704 SSKIELNRKLIQDQQEQIQHLKSTTNEL-KSEKLQISTNLQRRQQLEEQTVELSTEVQSL 762
+S +E + ++ +E + K T E+ K+ ++++ + + + QLE++ +E+ E Q L
Sbjct: 959 TSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQEL 1018
Query: 763 Y----REIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGY 818
R I+ ++Q+S L+ TL Q E +E + + +T+ Q D +E+ K
Sbjct: 1019 QDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAK----- 1073
Query: 819 MKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDID--TQKIQE 876
+ ++ Y E EL A + + KE++++ M +RQ ++ TQK +
Sbjct: 1074 ------IAVEAQNKY----ERELMLHAADVEALQAAKEQVSK-MASVRQHLEETTQKAES 1122
Query: 877 RWLQDNLTLRKRNEELKEVEEE---RKQHLKEMGQMQVLQMKSEHQKLEENI-DNIKRNH 932
+ L+ + +R LK+ + R + L++ ++ Q++ K+ ++ + ++
Sbjct: 1123 QLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPL 1182
Query: 933 NLALGRQKGYEEEIIHF------KKELREPQFRDAEEK-----------YREMMIVMRTT 975
N++L + +E+I+ +KE+ E +F A+ + RE+ + +
Sbjct: 1183 NVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSL 1242
Query: 976 ELVNKDLDIYYKTLDQ------------AIMKFHSMKMEEINKIIRDLWRSTYRGQDIEY 1023
+ + + KT+ Q +M+ + M EE ++ +DL + + + +E
Sbjct: 1243 NAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLE- 1301
Query: 1024 IEIRSDADENVSASDKRRNYNYRVVMLKGDTALDMRGRCSAGQKVLASLIIRLALAETFC 1083
++I + N S+K +L+ D R A + L S E
Sbjct: 1302 LDILPLQEANAELSEKSGMLQAEKKLLEEDVK-----RWKARNQHLVSQQKDPDTEEYRK 1356
Query: 1084 LNCGIIALDEPTTNLDRENIESLAHALVEIIKSRSQQRNFQLLVITHDEDFVELLGRSEY 1143
L ++ E T ++ E + EI +S + N Q L+ + ED ++ E
Sbjct: 1357 L----LSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKET 1412
Query: 1144 VEK 1146
++K
Sbjct: 1413 IQK 1415
Score = 118 bits (296), Expect = 3e-26
Identities = 216/1100 (19%), Positives = 456/1100 (41%), Gaps = 157/1100 (14%)
Query: 100 EIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQME---KDNSELEEKMEK 156
EI K + + L N +E + ++ KL+N++KAL + K++E N ++ + +
Sbjct: 56 EIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTR 115
Query: 157 VFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQ- 215
+ + + DL ++R +E E D R EKL KES N K EL ++ LQ
Sbjct: 116 TKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKL-KES---NTTKGELQLKLDELQA 171
Query: 216 --LQADRHQEHIRARDSLIQSLATQLELD-----------GFERGPFSERQIKNFHKLVR 262
+ ++ + L+ S T L + G E+G +I K
Sbjct: 172 SDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKG----NEILEL-KCNL 226
Query: 263 ERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVK 322
E ++ E + MN QK ++++ K L E ++ + K NEL N
Sbjct: 227 ENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTK---LKEAKEQQASMEEKFHNEL-NAH 282
Query: 323 YELQQL--------EGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKAD 374
+L L E S+ + +EL K +E +A K L++E Q EK
Sbjct: 283 IKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEM 342
Query: 375 LDRTLRKLDQEMEQLNH-HTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPN 433
L++ + +L++E+E N + T+ + +L++++ ++ L +
Sbjct: 343 LEK-IGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNA 401
Query: 434 KKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDV 493
+ +D L + E + L ++ KE+ + E +R ++ ++S KL
Sbjct: 402 YVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKL--- 458
Query: 494 CGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEA 553
+ ++ RL+E+ +K++KQ ++L + L+ + + +
Sbjct: 459 ---EQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHV 515
Query: 554 ELQEVIS--DLQSKLRLAPDKLKSTES--ELKKKEKRRDEMLGLVPMRQSIIDLKEKE-- 607
E +S D+ S + L S + EL+++ +R LV +R+ + + +E+E
Sbjct: 516 IRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRL-----LVALRE-LGETREREEQ 569
Query: 608 ------IPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVT--IMERF 659
I EL+ KL++ ++++L+ + Q L+ +I+ + + ++ L+ T +
Sbjct: 570 ETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLH 629
Query: 660 QMELKDVE----------RKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIEL 709
L DV + A + I+ ++ KQ ++ + K E
Sbjct: 630 ASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAE- 688
Query: 710 NRKLIQDQQEQIQHLKSTTNELKSEKLQISTNL-------------------------QR 744
N K+ Q EQ++ L+ +L+S+ +IST L +R
Sbjct: 689 NEKI---QNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHER 745
Query: 745 RQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDK 804
Q+L T + + ++ ++++ A E+++ E E ++EKE L K + +++Q +
Sbjct: 746 NQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEML---KLSEVRLSQQR 802
Query: 805 LNDIKEK--VKNIHGYMKDIENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDM 862
+ + E+ + ++ I+ ++ + + K++ +++ K+ ++S +K E E
Sbjct: 803 ESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQR 862
Query: 863 RLMRQDIDTQKIQ-ERWLQDNLTLRKRNEE-LKEVEEE---RKQHLKEMGQMQVLQMKSE 917
+ +++D Q + +R L L +E LK ++E KQHL M ++QV S+
Sbjct: 863 HTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNM-EVQVASQSSQ 921
Query: 918 H-------------------QKLEENIDNIKRNHNLALGRQKGYE------EEIIHFKKE 952
++ EE ++++K + + Y+ EE ++ +K+
Sbjct: 922 RTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQ 981
Query: 953 LREPQFRDAEEKYRE-----------MMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKM 1001
+ E ++ E + +E +M V + + + D ++++Q + +
Sbjct: 982 VTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLS 1041
Query: 1002 EEINKIIRDLWRSTYRGQDIEYIEIRSDADENVSASDKRRNYNYRVVMLKGDTALDMRGR 1061
N++ L R++ + + + R D E + + +N R +ML A D+
Sbjct: 1042 SVQNEVQEALQRASTALSNEQ--QARRDCQEQAKIAVEAQNKYERELMLH---AADVEAL 1096
Query: 1062 CSAGQKVLASLIIRLALAET 1081
+A ++V +R L ET
Sbjct: 1097 QAAKEQVSKMASVRQHLEET 1116
Score = 95.5 bits (236), Expect = 3e-19
Identities = 171/836 (20%), Positives = 360/836 (43%), Gaps = 97/836 (11%)
Query: 140 KKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRL 199
+ ++ K ++ K+EK +++ L H++ E E++ + + L + + RL
Sbjct: 11 RTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLS--HSQERL 68
Query: 200 LNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHK 259
+N+ + E L+L+ ++ ++A + +LE+ +R I +
Sbjct: 69 VNETR-----ECQSLRLELEKLNNQLKA----LTEKNKELEI-------AQDRNIAIQSQ 112
Query: 260 LVRERQEGEAK-----TANQLMNDFAEKETLKQKQIDE-IRDKKTGLGRIIELKSEILSK 313
R ++E EA+ N+ ++ E T K+++E +++ T G ++LK L +
Sbjct: 113 FTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGE-LQLK---LDE 168
Query: 314 KQNELKNVKYELQQLEGSSDRILE----LDQELIKAERELSKAEKNSNVETLKMEVISLQ 369
Q +VKY ++LE + + L+ EL EL + E L+++ +L+
Sbjct: 169 LQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELK-CNLE 227
Query: 370 NEKADLDRTLRKLDQEMEQL---NHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTS 426
N+K ++ R L+++M L N H + ++LTK K K++Q ++ + +EL +
Sbjct: 228 NKKEEVSR----LEEQMNGLKTSNEHLQKHVE-DLLTKLKEAKEQQ-ASMEEKFHNELNA 281
Query: 427 LLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSY 486
+ K D +KS E+ + + L KL KE + E NK I + L E+
Sbjct: 282 HIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKE--AGEANK-AIQDHLLEVEQSKDQM 338
Query: 487 EDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQ 546
E ++ + G RL++E+E ++ + A+ S+ +
Sbjct: 339 EKEMLEKIG---------RLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIV 389
Query: 547 RVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEK 606
+ EL + Q +L L + K L + K + ++ ++ + +K
Sbjct: 390 KPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQK 449
Query: 607 EIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMER-FQMELKD 665
+ L KL+ ++IQRL+ D ++ + + ++ + D++ R MEL++
Sbjct: 450 AVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEE 509
Query: 666 VERKIAQQAAKLQGIDLDRTVQQVNQ--------EKQEKQHKLDTVSSKIELNRKLIQDQ 717
+ ++ D+ + + ++Q E+ ++Q++ V+ + EL +++
Sbjct: 510 ARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALR-ELGETREREE 568
Query: 718 QEQIQHLKSTTNELKSEK-LQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPL 776
QE K T +LK E L L++ +Q + Q V+ + +YR + Q + +
Sbjct: 569 QETTSS-KITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRIL---LSQTTGV 624
Query: 777 ETTLEKFQQEKEELIN---KKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDY 833
L + L + + +TS ++ + E + I K +Q+ ++Y
Sbjct: 625 AIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEA--KAALKQLQEIFENY 682
Query: 834 KKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQ----KIQERWLQDNL------ 883
KK+K E K+ Q + EK +E++ D+R I TQ + LQDN+
Sbjct: 683 KKEK-AENEKI--QNEQLEKLQEQVT-DLRSQNTKISTQLDFASKRYEMLQDNVEGYRRE 738
Query: 884 --TLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKL---EENIDNIKRNHNL 934
+L +RN++L ++++Q + M Q ++ ++KL E +N+K+ +
Sbjct: 739 ITSLHERNQKLTATTQKQEQIINTMTQ----DLRGANEKLAVAEVRAENLKKEKEM 790
Score = 80.5 bits (197), Expect = 9e-15
Identities = 139/676 (20%), Positives = 284/676 (42%), Gaps = 105/676 (15%)
Query: 382 LDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSD-ELTSLLGYFPNKKQLEDW 440
L Q +E+ + ++ L K AD+ +I +K RH ++ S YF +K+L
Sbjct: 5 LQQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLS-- 62
Query: 441 LHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELK---RKEEQLSSYEDKLFDVCGSQ 497
HS+ + +N+TR E S +NN+LK K ++L +D+ +
Sbjct: 63 -HSQERLVNETR--------ECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAI---- 109
Query: 498 DFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQE 557
+S R KEE+E + L SQ + LT++ +R+ + E
Sbjct: 110 --QSQFTRTKEELEAEKRD---LIRTNERLSQELEYLTED-------VKRLNEKLKESNT 157
Query: 558 VISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSII--DLKEK--------- 606
+LQ KL D+L++++ +K +EKR ++ L+ + + + +LK K
Sbjct: 158 TKGELQLKL----DELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGR 213
Query: 607 ----EIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQME 662
EI EL+ L+N ++ RL +E + G E K +E +
Sbjct: 214 EKGNEILELKCNLENKKEEVSRL------EEQMNGLKTSNEHLQK-------HVEDLLTK 260
Query: 663 LKDVERKIAQQAAKLQGIDLDRTVQQVNQEK---QEKQHKLDTVSSKIELNRKLIQDQQE 719
LK+ + + A K +L+ ++ N K + + K + ++ +E KL+++ E
Sbjct: 261 LKEAKEQQASMEEKFHN-ELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGE 319
Query: 720 QIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYRE-----IKDAKEQVS 774
+ ++ E++ K Q+ + + E+ +E + ++ S + ++ +S
Sbjct: 320 ANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMS 379
Query: 775 PLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYK 834
P + K + +L N + QD+L K + K I+ Y+ +I ++ K
Sbjct: 380 PTAAAVAKIVKPGMKLTELYNAYVE-TQDQLLLEKLENKRINKYLDEIVKEVEAKAPILK 438
Query: 835 KQKE-------------TELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQD 881
+Q+E +L + + ++ ++ +K N+ ++ +D +IQ + L
Sbjct: 439 RQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQ 498
Query: 882 NLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKG 941
+ + L E+EE R H+ ++ + S + + +++ + + L Q+
Sbjct: 499 QIRVL-----LMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQR- 552
Query: 942 YEEEIIHFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKM 1001
++ +EL E + R+ +E + TEL K L+ L+Q + K +M
Sbjct: 553 ----LLVALRELGETREREEQETTSS-----KITELQLK-LESALTELEQ-LRKSRQHQM 601
Query: 1002 EEINKIIRDLWRSTYR 1017
+ ++ I+R R YR
Sbjct: 602 QLVDSIVRQ--RDMYR 615
Score = 73.6 bits (179), Expect = 1e-12
Identities = 115/529 (21%), Positives = 230/529 (43%), Gaps = 76/529 (14%)
Query: 544 VCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDL 603
V Q+V + EL ++ +Q+KL L +SE+ + R ++ V Q ++
Sbjct: 4 VLQQVLE-RTELNKLPKSVQNKLEKF---LADQQSEIDGLKGRHEKFK--VESEQQYFEI 57
Query: 604 KEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLT-DVTIMERF--- 659
EK + + +L N R+ Q L+ ++E+ L + + + ++ ++ I +F
Sbjct: 58 -EKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRT 116
Query: 660 ----QMELKDVERKIAQQAAKLQGID-----LDRTVQQVNQEKQEKQHKLDTVSS----- 705
+ E +D+ R + + +L+ + L+ +++ N K E Q KLD + +
Sbjct: 117 KEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSV 176
Query: 706 -----KIELNRKLIQDQQEQIQ-HLKSTTNELKS-------EKLQISTNLQRRQQ----L 748
++E ++L+ Q + LK+ T+EL + E L++ NL+ +++ L
Sbjct: 177 KYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRL 236
Query: 749 EEQTVELSTE-------VQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIA 801
EEQ L T V+ L ++K+AKEQ + +E EKF E I N A
Sbjct: 237 EEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASME---EKFHNELNAHIKLSNLYKSAA 293
Query: 802 QD---KLNDIKEKVKNIHGYMK---DIENYIQDGKDDYKKQKETELNKVIAQLSECEKHK 855
D K N++ V+ +H +K + IQD + ++ K+ +++ ++ EK
Sbjct: 294 DDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKEL 353
Query: 856 EKINEDMRLMRQD--IDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQ 913
E N+ + ++ I +++ + K + ++ E +++ Q Q+L
Sbjct: 354 ENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVET--QDQLLL 411
Query: 914 MKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKYREMMIVMR 973
K E++++ + +D I + K EE +K + + E+ +E+ +
Sbjct: 412 EKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVK-LEQAMKEIQRLQE 470
Query: 974 TTELVNKD----------LDIYYKTLDQAIMKFHSMKMEEI--NKIIRD 1010
T+ NK ++I K L Q I + M++EE N +IRD
Sbjct: 471 DTDKANKQSSVLERDNRRMEIQVKDLSQQI-RVLLMELEEARGNHVIRD 518
Score = 42.0 bits (97), Expect = 0.003
Identities = 50/236 (21%), Positives = 101/236 (42%), Gaps = 24/236 (10%)
Query: 14 NVIFCHQEDSNWPLSEGKALKQKFDEIFSATRYIKALETLRQVRQTQGQKV-KEYQMELK 72
N+I +ED N +E + +++ D + I E ++ + TQ +K+ + Y+ + +
Sbjct: 1394 NLIQSLKEDLNKVRTEKETIQKDLD-----AKIIDIQEKVKTI--TQVKKIGRRYKTQYE 1446
Query: 73 YLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKL--- 129
LK ++K E Q + + S + ++ + L+ + + K +E + + K
Sbjct: 1447 ELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSE 1506
Query: 130 -DNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERK----LV 184
+ E + L + Q++ + S L + ++ +EQL ++ + EKE K +V
Sbjct: 1507 KETEARNLQEQTVQLQSELSRLRQDLQD-RTTQEEQL-------RQQITEKEEKTRKAIV 1558
Query: 185 DCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLE 240
++ L L +E EL G L Q D I A S + ++LE
Sbjct: 1559 AAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLE 1614
>gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
Length = 1780
Score = 127 bits (318), Expect = 8e-29
Identities = 188/890 (21%), Positives = 399/890 (44%), Gaps = 127/890 (14%)
Query: 83 EIRDQITSKEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQ 142
+I+ ++ + +L +KE +K ENE D L ++E+E + KI+ + IK L + Q
Sbjct: 679 QIKAELAKTKGELIKTKEELKKRENESDSL---IQELETSNKKIITQNQRIKELINIIDQ 735
Query: 143 MEKDNSE---LEEKMEKVFQGTDE-QLNDLYHNHQRTVREKERKLVDCHRELEKLNKESR 198
E +E L+ ME F+ D+ + L N+ KL+ C+ +E + K+S
Sbjct: 736 KEDTINEFQNLKSHMENTFKCNDKADTSSLIINN---------KLI-CNETVE-VPKDS- 783
Query: 199 LLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFH 258
KS++ E+ R+ + E + S+ S A + E + +I++
Sbjct: 784 -----KSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDI- 837
Query: 259 KLVRERQEG----EAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKK 314
++++E EG N+L N+ EK L KQI + + + + E K+ LSK+
Sbjct: 838 RVLQENNEGLRAFLLTIENELKNEKEEKAEL-NKQIVHFQQELS----LSEKKNLTLSKE 892
Query: 315 QNELK-NVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKA 373
+++ N + +L + E +++++K E+ A ++ T + I L + K
Sbjct: 893 VQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSI---TNNVSQIKLMHTKI 949
Query: 374 DLDRTLRKLDQ--EMEQLN---------HHTTTRTQMEMLTKD----KADKDEQIRKIKS 418
D RTL + Q ++ LN TQ+++L D K K+ +I++ +
Sbjct: 950 DELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQE-PN 1008
Query: 419 RHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKR 478
R + +S+ + K++ KS +I + ++ KL E+ + NN LK
Sbjct: 1009 RENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDE----NNRLKE 1064
Query: 479 KEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDEN 538
KE + + +D L ++ E+ + +LKEE+++ + + + +++LT +
Sbjct: 1065 KEHK--NQDDLL------KEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELT-QG 1115
Query: 539 QSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQ 598
+C + +T E Q+V +KL + ES + K E+ E ++
Sbjct: 1116 VTCYKAKIKELETILETQKVECSHSAKLE---QDILEKESIILKLERNLKEF--QEHLQD 1170
Query: 599 SIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMER 658
S+ + K+ + EL+ K +I +L N++++ + LL EEE+ +
Sbjct: 1171 SVKNTKDLNVKELKLK-----EEITQLTNNLQDMKHLLQLKEEEEETNR----------- 1214
Query: 659 FQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQ 718
E + ++ +++ +A+ Q + D +Q+ ++ + + KL +I+ +K + +
Sbjct: 1215 --QETEKLKEELSASSARTQNLKAD--LQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMR 1270
Query: 719 EQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVEL--STEVQSLYREIKDAKEQVSPL 776
++ + L+ NEL+ +K Q S L +Q+ +Q E + +V+ ++ + A + ++
Sbjct: 1271 DEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVK 1330
Query: 777 ETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQ 836
E +E + EE + +++ + KL +++ + + + + + K++ +
Sbjct: 1331 EKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDL--ETKNNQRSN 1388
Query: 837 KETE-----LNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTL------ 885
KE E L K+ E ++ ++K N D +++WL++ + L
Sbjct: 1389 KEHENNTDVLGKLTNLQDELQESEQKYNAD-------------RKKWLEEKMMLITQAKE 1435
Query: 886 --RKRNEELKEVEEERKQHLKEMGQMQVL-----QMKSEHQKLEENIDNI 928
RN+E+K+ E+R++ K+ +M++L + S+ QK E D +
Sbjct: 1436 AENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKWREERDQL 1485
Score = 104 bits (260), Expect = 4e-22
Identities = 174/871 (19%), Positives = 381/871 (43%), Gaps = 94/871 (10%)
Query: 201 NQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKL 260
NQ K+EL +G L + ++ DSLIQ L T ++ ++IK +
Sbjct: 678 NQIKAELAKTKGELIKTKEELKKRENESDSLIQELET-----SNKKIITQNQRIKELINI 732
Query: 261 VRERQEGEAKTANQLMNDFAEKETL-----KQKQIDEIRDKKTGLGRIIELKSEILSKKQ 315
+ ++++ T N+ N + E K I + K +E+ + SK
Sbjct: 733 IDQKED----TINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKIC 788
Query: 316 NELKNV-KYELQQLE-----GS---SDRILELDQELIKAERELSKAEK----NSNVETLK 362
+E K V + ELQQ E GS S I E ++ + +++ E N E L+
Sbjct: 789 SERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEGLR 848
Query: 363 MEVISLQN-------EKADLDRTLRKLDQEM---EQLNHHTTTRTQMEMLTKDKADKDEQ 412
+++++N EKA+L++ + QE+ E+ N + Q D A +
Sbjct: 849 AFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELH 908
Query: 413 IRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHI 472
++K K++ +E L ++E S + ++Q + K+++ ++
Sbjct: 909 VQKSKNQEQEEKIMKL-----SNEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQISN 963
Query: 473 NNELKRKEEQLSSYEDKL----FDVCGSQDFESDLDRLKE-EIEKSSKQRAMLAGATAVY 527
+ L ++ S ED L D+ G+ S ++KE I++ +++ + + A++
Sbjct: 964 IDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVS--KQVKEYRIQEPNRENSFHSSIEAIW 1021
Query: 528 SQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRR 587
+ + ++ + + Q E EV RL + K+ + LK+KE
Sbjct: 1022 EECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLI 1081
Query: 588 DEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPE-EESA 646
++ + + +D++ + + E + L + + + K I+E ET+L T E SA
Sbjct: 1082 QQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSA 1141
Query: 647 KVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSK 706
K+ + I+E+ + LK +ER + + LQ D + + +N ++ + + ++ +++
Sbjct: 1142 KL---EQDILEKESIILK-LERNLKEFQEHLQ--DSVKNTKDLNVKELKLKEEITQLTNN 1195
Query: 707 IELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREI 766
++ + L+Q ++E+ + + T +LK E +S + R Q L+ + L ++
Sbjct: 1196 LQDMKHLLQLKEEEEETNRQETEKLKEE---LSASSARTQNLKADLQRKEEDYADLKEKL 1252
Query: 767 KDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYI 826
DAK+Q+ ++ + + E +K+ + K+N++++K + + I
Sbjct: 1253 TDAKKQIKQVQKEVSVMRDE-----------DKLLRIKINELEKKKNQCSQELDMKQRTI 1301
Query: 827 QDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQDNLTLR 886
Q K+ QK E + + + KEKI EDMR+ ++ + ++++ + L
Sbjct: 1302 QQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQ-----DQVLE 1356
Query: 887 KRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEI 946
+ EE++ + E ++ ++ ++ + +++ E N D LG+ ++E+
Sbjct: 1357 AKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTD--------VLGKLTNLQDEL 1408
Query: 947 IHFKKELREPQFRDAEEKYREMMIVMRTTE---LVNKDLDIYYKTLDQAIMKFHSMKM-- 1001
+++ + + EEK MM++ + E + NK++ Y + ++ + + M++
Sbjct: 1409 QESEQKYNADRKKWLEEK---MMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILT 1465
Query: 1002 EEINKIIRDL--WRSTYRGQDIEYIEIRSDA 1030
++ + DL WR R Q + +EI+ A
Sbjct: 1466 AQLTEKDSDLQKWREE-RDQLVAALEIQLKA 1495
Score = 91.3 bits (225), Expect = 5e-18
Identities = 169/830 (20%), Positives = 351/830 (42%), Gaps = 178/830 (21%)
Query: 47 IKALETLRQVRQTQGQKVKEYQMELKY-LKQYKEKACEIRDQIT--------SKEAQLTS 97
I +E +R V Q + ++ + + ++ LK KE+ E+ QI S++ LT
Sbjct: 831 IAEIEDIR-VLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTL 889
Query: 98 SKEIVKSYEN------ELDPLKNRLKEIEHNLSKIMKLDNEI----KALDSRKKQMEKDN 147
SKE+ + N EL K++ +E E KIMKL NEI +++ + Q++ +
Sbjct: 890 SKEVQQIQSNYDIAIAELHVQKSKNQEQEE---KIMKLSNEIETATRSITNNVSQIKLMH 946
Query: 148 SELEE--KMEKVFQGTDEQLNDLYH----NHQRTVREKERKLVDCHRELEKLNKESRLL- 200
++++E ++ V Q ++ L +L + + + + L+ + K KE R+
Sbjct: 947 TKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQE 1006
Query: 201 -NQEKS-----ELLVEQGRLQLQADRHQEH-IRARDSLIQSLATQLELDGF--ERGPFSE 251
N+E S E + E+ + ++A + H I + I+ L Q E+ G+ E E
Sbjct: 1007 PNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKL--QAEVKGYKDENNRLKE 1064
Query: 252 RQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEIL 311
++ KN L++E++ QL + EK QI + + K L + + +
Sbjct: 1065 KEHKNQDDLLKEKET----LIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVT-CY 1119
Query: 312 SKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNE 371
K EL+ + E Q++E S +L+Q++++ E + K E+N
Sbjct: 1120 KAKIKELETI-LETQKVECSHSA--KLEQDILEKESIILKLERN---------------- 1160
Query: 372 KADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYF 431
L++ + ++ +T KD ++++K + +E+T L
Sbjct: 1161 -------LKEFQEHLQDSVKNT---------------KDLNVKELKLK--EEITQLTNNL 1196
Query: 432 PNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLF 491
+ K L L K +E R KL +EL++S ++ +L+RKEE + ++KL
Sbjct: 1197 QDMKHL---LQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLT 1253
Query: 492 DVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQT 551
D K++I++ K+ +++ + I +L + C +T
Sbjct: 1254 DA-------------KKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRT 1300
Query: 552 EAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPEL 611
+L+E +++ + E +++ E+ + +++KEK I ++
Sbjct: 1301 IQQLKEQLNN------------QKVEEAIQQYERACKD-----------LNVKEKIIEDM 1337
Query: 612 RNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIA 671
R L+ ++ + +E+ + L + E A T +E+++ + D+E K
Sbjct: 1338 RMTLE------EQEQTQVEQDQVLEAKLEEVERLA-------TELEKWKEKCNDLETK-- 1382
Query: 672 QQAAKLQGIDLDRTVQQVNQEKQEKQHKLDT-VSSKIELNRKLIQDQQEQIQHLKSTTNE 730
N ++ K+H+ +T V K+ L + QE Q + +
Sbjct: 1383 ------------------NNQRSNKEHENNTDVLGKL---TNLQDELQESEQKYNADRKK 1421
Query: 731 LKSEKLQISTNLQRRQQLEEQTVELSTEVQSLY----REIKDAKEQVSPLETTLEKFQQE 786
EK+ + T + + + + ++ E + + E++ Q++ ++ L+K+++E
Sbjct: 1422 WLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKWREE 1481
Query: 787 KEELIN------KKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGK 830
+++L+ K S+ + +D N+I E++K I IE I D K
Sbjct: 1482 RDQLVAALEIQLKALISSNVQKD--NEI-EQLKRIISETSKIETQIMDIK 1528
Score = 86.3 bits (212), Expect = 2e-16
Identities = 186/912 (20%), Positives = 365/912 (40%), Gaps = 181/912 (19%)
Query: 250 SERQIKNFHKLVRERQEGEAKTA----NQLMNDFAEKETLKQKQIDEIRDKK-------- 297
SER +K ++ R R+ G T+ + +N E K +Q R+ K
Sbjct: 384 SERTMKTQNEGERLRETGNINTSLLTLGKCINVLKNSEKSKFQQHVPFRESKLTHYFQSF 443
Query: 298 -TGLGRIIELK--SEILSKKQNELKNVKYELQQLEGSSDRILELDQEL----IKAERELS 350
G G+I + S+ L +K+ + L QE +K+ +++S
Sbjct: 444 FNGKGKICMIVNISQCYLAYDETLNVLKFSAIAQKVCVPDTLNSSQEKLFGPVKSSQDVS 503
Query: 351 -KAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADK 409
+ NS + +K IS +N DL L +E+E N T + ++L +D DK
Sbjct: 504 LDSNSNSKILNVKRATISWENSLEDLMED-EDLVEELE--NAEETQNVETKLLDED-LDK 559
Query: 410 DEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHS-KSKEINQTRDRLAKLNKELASSEQN 468
+ K H + K++L D + K K IN+ +++L
Sbjct: 560 TLEENKAFISHEE-----------KRKLLDLIEDLKKKLINEKKEKLTL----------- 597
Query: 469 KNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYS 528
E K +EE + + DF+ L + +E +E+++++R A++
Sbjct: 598 ------EFKIREEVTQEFTQ--YWAQREADFKETLLQEREILEENAERRL------AIFK 643
Query: 529 QFITQLTDENQSCCPVCQRVFQTE---AELQEVISDLQSKLRLAPDKLKSTESELKKKEK 585
+ + ++ +C +TE A L+ + ++++L +L T+ ELKK+E
Sbjct: 644 DLVGKCDTREEAAKDICATKVETEEATACLELKFNQIKAELAKTKGELIKTKEELKKREN 703
Query: 586 RRDEML--------GLVPMRQ------SIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEE 631
D ++ ++ Q +IID KE I E +N ++ + ND +
Sbjct: 704 ESDSLIQELETSNKKIITQNQRIKELINIIDQKEDTINEFQNLKSHMENTFK--CNDKAD 761
Query: 632 QETLL---------GTIMPEEESAKVCLTDVTIME---------------RFQMELKDVE 667
+L+ +P++ +K+C + E + + +
Sbjct: 762 TSSLIINNKLICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQ 821
Query: 668 RKIAQQAAKLQGIDLDRTVQQVNQ---------EKQEKQHKLDTVSSKIELNRKLIQDQQ 718
+K + + I+ R +Q+ N+ E + K K K ELN++++ QQ
Sbjct: 822 KKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTIENELKNEK----EEKAELNKQIVHFQQ 877
Query: 719 E-QIQHLKSTTNELKSEKLQISTNL-----------QRRQQLEEQTVELSTEVQSLYREI 766
E + K+ T L E QI +N + Q+ EE+ ++LS E+++ R I
Sbjct: 878 ELSLSEKKNLT--LSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSI 935
Query: 767 KDAKEQVSPLETTLEKF-------QQEKEELINKKNTSNKIAQDKL-NDIKEKVKNIHGY 818
+ Q+ + T +++ Q +L+N ++ SN +D L N + + N +
Sbjct: 936 TNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLV 995
Query: 819 MKDIENY-IQDGKDDYKKQKETEL------------NKVIAQLSECEKHKEKINEDMRLM 865
K ++ Y IQ+ + E +K Q+ E E+ EK+ +++
Sbjct: 996 SKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGY 1055
Query: 866 RQDIDTQKIQERWLQDNLTLRKRN--EELKEVEEER--------------KQHLKEMGQM 909
+ + + K +E QD+L K ++LKE +E+ K+ L E+ Q
Sbjct: 1056 KDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQ- 1114
Query: 910 QVLQMKSEHQKLEENID--NIKRNHNLALGRQKGYEEEII--------HFKKELREPQFR 959
V K++ ++LE ++ ++ +H+ L + +E II F++ L++
Sbjct: 1115 GVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKN 1174
Query: 960 DAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQ 1019
+ +E+ + T+L N D+ K L Q + +E K+ +L S+ R Q
Sbjct: 1175 TKDLNVKELKLKEEITQLTNNLQDM--KHLLQLKEEEEETNRQETEKLKEELSASSARTQ 1232
Query: 1020 DIEYIEIRSDAD 1031
+++ R + D
Sbjct: 1233 NLKADLQRKEED 1244
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.128 0.339
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,005,189
Number of Sequences: 37866
Number of extensions: 1743042
Number of successful extensions: 27101
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 383
Number of HSP's successfully gapped in prelim test: 1391
Number of HSP's that attempted gapping in prelim test: 9501
Number of HSP's gapped (non-prelim): 8264
length of query: 1173
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1060
effective length of database: 13,968,660
effective search space: 14806779600
effective search space used: 14806779600
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.