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Search of human proteins with 19923981
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|19923981 IQ motif containing D [Homo sapiens]
(347 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|19923981 IQ motif containing D [Homo sapiens] 664 0.0
gi|197313718 IQ motif containing G [Homo sapiens] 54 3e-07
gi|14165288 IQ motif containing G [Homo sapiens] 54 3e-07
gi|45446749 kinesin family member 5A [Homo sapiens] 52 8e-07
gi|221219020 NYD-SP11 protein [Homo sapiens] 50 2e-06
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 50 2e-06
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 50 2e-06
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 50 2e-06
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 50 3e-06
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 50 3e-06
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 50 3e-06
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 50 3e-06
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 50 3e-06
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 50 3e-06
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 50 3e-06
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 50 3e-06
gi|154354990 ankyrin repeat domain 26 [Homo sapiens] 50 4e-06
gi|46593000 GRIP1 associated protein 1 isoform 2 [Homo sapiens] 49 5e-06
gi|46592991 GRIP1 associated protein 1 isoform 1 [Homo sapiens] 49 5e-06
gi|148746195 trichohyalin [Homo sapiens] 47 3e-05
gi|88196790 coiled-coil domain containing 88 [Homo sapiens] 46 4e-05
gi|10440566 leucine zipper, putative tumor suppressor 1 [Homo sa... 46 6e-05
gi|68299759 ecotropic viral integration site 5 [Homo sapiens] 45 7e-05
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 45 7e-05
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 45 7e-05
gi|110611218 ribosome binding protein 1 [Homo sapiens] 45 1e-04
gi|110611220 ribosome binding protein 1 [Homo sapiens] 45 1e-04
gi|116256481 TNFAIP3 interacting protein 1 [Homo sapiens] 45 1e-04
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 45 1e-04
gi|33356174 pinin, desmosome associated protein [Homo sapiens] 45 1e-04
>gi|19923981 IQ motif containing D [Homo sapiens]
Length = 347
Score = 664 bits (1713), Expect = 0.0
Identities = 347/347 (100%), Positives = 347/347 (100%)
Query: 1 MALDILAMAPLYQAPAINRIGPKTDPSKRPADPLKPLVLSRTKLTTIEAKRIMSILDEAI 60
MALDILAMAPLYQAPAINRIGPKTDPSKRPADPLKPLVLSRTKLTTIEAKRIMSILDEAI
Sbjct: 1 MALDILAMAPLYQAPAINRIGPKTDPSKRPADPLKPLVLSRTKLTTIEAKRIMSILDEAI 60
Query: 61 YKVELVTLLSYVASNREDMEGMLGEDVMRAVREHEDLCQVLLENVRCLKEKERQLQEQKE 120
YKVELVTLLSYVASNREDMEGMLGEDVMRAVREHEDLCQVLLENVRCLKEKERQLQEQKE
Sbjct: 61 YKVELVTLLSYVASNREDMEGMLGEDVMRAVREHEDLCQVLLENVRCLKEKERQLQEQKE 120
Query: 121 AEEEGWLRDRLLSIELQKSSLSPLMQQIKDSTKNVLRLLLSNPQAARLLQMQTQGRSAEA 180
AEEEGWLRDRLLSIELQKSSLSPLMQQIKDSTKNVLRLLLSNPQAARLLQMQTQGRSAEA
Sbjct: 121 AEEEGWLRDRLLSIELQKSSLSPLMQQIKDSTKNVLRLLLSNPQAARLLQMQTQGRSAEA 180
Query: 181 QNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNR 240
QNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNR
Sbjct: 181 QNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNR 240
Query: 241 NAEEELEDLDAVHREEKISLEELRRRHKVLVGEFAQIREEREINSKKRMEAEQEMVRMVR 300
NAEEELEDLDAVHREEKISLEELRRRHKVLVGEFAQIREEREINSKKRMEAEQEMVRMVR
Sbjct: 241 NAEEELEDLDAVHREEKISLEELRRRHKVLVGEFAQIREEREINSKKRMEAEQEMVRMVR 300
Query: 301 AATLIQALWKGYLVRSLLRSKKKRGKGKAKDKEKGKQKGKEKGKGKK 347
AATLIQALWKGYLVRSLLRSKKKRGKGKAKDKEKGKQKGKEKGKGKK
Sbjct: 301 AATLIQALWKGYLVRSLLRSKKKRGKGKAKDKEKGKQKGKEKGKGKK 347
>gi|197313718 IQ motif containing G [Homo sapiens]
Length = 443
Score = 53.5 bits (127), Expect = 3e-07
Identities = 72/320 (22%), Positives = 142/320 (44%), Gaps = 52/320 (16%)
Query: 32 DPLKPLVLSRTKLTTIEAKRIMSILDEAIYKVELVTLLSYVASNREDMEGMLGEDVMRAV 91
+ LK + + R + + A I + D A Y +LL ++ RE+ M D++
Sbjct: 163 ETLKKIQIDRQFFSDVIADTIKELQDSATYN----SLLQALSKERENK--MHFYDII--A 214
Query: 92 REHEDLCQVL-LENVRCLKEKERQLQEQKEAEEEGWLRDRLLSIELQKSSLSPLMQQIKD 150
RE + Q++ L+ +KE Q + Q + E L+D+L ++ + +
Sbjct: 215 REEKGRKQIISLQKQLINVKKEWQFEVQSQNEYIANLKDQLQEMKAKSN----------- 263
Query: 151 STKNVLRLLLSNPQAARLLQMQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQ 210
L N R ++ T+ + A+ Q + EL L E++ M+ ++A+
Sbjct: 264 ---------LEN----RYMKTNTELQIAQTQKKCNRTEEL---LVEEIEKLRMKTEEEAR 307
Query: 211 FLQDISRQNSNNQQIIDTLEKELAERMKNRNAEEELE--DLDAVHREEKISLEELRRRHK 268
+I QQ LE+ L M+ + + E++ +L+A+ + L L+ K
Sbjct: 308 THTEIEMFLRKEQQ---KLEERLEFWMEKYDKDTEMKQNELNALKATKASDLAHLQDLAK 364
Query: 269 VLVGEFAQIREEREINSKKRMEAEQEMVRMVRAATLIQALWKGYLVR----------SLL 318
++ E+ Q+ E I ++ + ++ + +++ +QA W+G ++R +
Sbjct: 365 -MIREYEQVIIEDRIEKERSKKKVKQDLLELKSVIKLQAWWRGTMIRREIGGFKMPKDKV 423
Query: 319 RSKKKRGKGKAKDKEKGKQK 338
SK +GKGK KDK +GK+K
Sbjct: 424 DSKDSKGKGKGKDKRRGKKK 443
>gi|14165288 IQ motif containing G [Homo sapiens]
Length = 443
Score = 53.5 bits (127), Expect = 3e-07
Identities = 72/320 (22%), Positives = 142/320 (44%), Gaps = 52/320 (16%)
Query: 32 DPLKPLVLSRTKLTTIEAKRIMSILDEAIYKVELVTLLSYVASNREDMEGMLGEDVMRAV 91
+ LK + + R + + A I + D A Y +LL ++ RE+ M D++
Sbjct: 163 ETLKKIQIDRQFFSDVIADTIKELQDSATYN----SLLQALSKERENK--MHFYDII--A 214
Query: 92 REHEDLCQVL-LENVRCLKEKERQLQEQKEAEEEGWLRDRLLSIELQKSSLSPLMQQIKD 150
RE + Q++ L+ +KE Q + Q + E L+D+L ++ + +
Sbjct: 215 REEKGRKQIISLQKQLINVKKEWQFEVQSQNEYIANLKDQLQEMKAKSN----------- 263
Query: 151 STKNVLRLLLSNPQAARLLQMQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQ 210
L N R ++ T+ + A+ Q + EL L E++ M+ ++A+
Sbjct: 264 ---------LEN----RYMKTNTELQIAQTQKKCNRTEEL---LVEEIEKLRMKTEEEAR 307
Query: 211 FLQDISRQNSNNQQIIDTLEKELAERMKNRNAEEELE--DLDAVHREEKISLEELRRRHK 268
+I QQ LE+ L M+ + + E++ +L+A+ + L L+ K
Sbjct: 308 THTEIEMFLRKEQQ---KLEERLEFWMEKYDKDTEMKQNELNALKATKASDLAHLQDLAK 364
Query: 269 VLVGEFAQIREEREINSKKRMEAEQEMVRMVRAATLIQALWKGYLVR----------SLL 318
++ E+ Q+ E I ++ + ++ + +++ +QA W+G ++R +
Sbjct: 365 -MIREYEQVIIEDRIEKERSKKKVKQDLLELKSVIKLQAWWRGTMIRREIGGFKMPKDKV 423
Query: 319 RSKKKRGKGKAKDKEKGKQK 338
SK +GKGK KDK +GK+K
Sbjct: 424 DSKDSKGKGKGKDKRRGKKK 443
>gi|45446749 kinesin family member 5A [Homo sapiens]
Length = 1032
Score = 52.0 bits (123), Expect = 8e-07
Identities = 62/252 (24%), Positives = 112/252 (44%), Gaps = 46/252 (18%)
Query: 91 VREHEDLCQVLLENVRCLKEKERQLQEQKEAEEEGWLRDRLLSIELQKSSLSPLMQ---- 146
+ +HE + L E ++ ++ K+R L+E ++ L D L ++ Q++ ++
Sbjct: 633 ISQHEAKIRSLTEYMQSVELKKRHLEESYDS-----LSDELAKLQAQETVHEVALKDKEP 687
Query: 147 --QIKDSTKNVLRLLLSNPQAARLLQM-QTQGRSAEAQNFIDSLIELRGFL--------- 194
Q D K L L + + + A Q+ + + E Q ID L +L L
Sbjct: 688 DTQDADEVKKALELQMESHREAHHRQLARLRDEINEKQKTIDELKDLNQKLQLELEKLQA 747
Query: 195 -FEKLLTSPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKN-------------- 239
+EKL + E K Q L + ++ ++Q + LE+ +A ++
Sbjct: 748 DYEKLKSEEHEKSTKLQELTFLYERHEQSKQDLKGLEETVARELQTLHNLRKLFVQDVTT 807
Query: 240 ---RNAEEELEDLDAVH-REEKIS-----LEELRRRHKVLVGEFAQIREEREINSKKRME 290
++AE E ED +H +++KIS LE+L + HK LV + A +R E +KR+
Sbjct: 808 RVKKSAEMEPEDSGGIHSQKQKISFLENNLEQLTKVHKQLVRDNADLRCELP-KLEKRLR 866
Query: 291 AEQEMVRMVRAA 302
A E V+ + A
Sbjct: 867 ATAERVKALEGA 878
Score = 32.7 bits (73), Expect = 0.49
Identities = 51/234 (21%), Positives = 91/234 (38%), Gaps = 29/234 (12%)
Query: 58 EAIYKVELVTLLSYVASNREDMEGMLGEDVMRAVREHEDLCQVLLEN-----VRCLKEKE 112
E I K+E N + E + GE+ +LC+ N V + +E
Sbjct: 358 ETIAKLEAELSRWRNGENVPETERLAGEEAALGA----ELCEETPVNDNSSIVVRIAPEE 413
Query: 113 RQLQEQKEAEEEGWLRDRLLSIELQKSSLSPLMQQIKDSTKNVLRLLLSNPQAARLL--- 169
RQ E++ L D+ I Q + L QQ+ D + ++ N + R L
Sbjct: 414 RQKYEEEIRRLYKQLDDKDDEINQQSQLIEKLKQQMLDQEELLVSTRGDNEKVQRELSHL 473
Query: 170 QMQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNSNNQQIIDTL 229
Q + E + + +L EL A + Q Q++ ++ NQ ++D L
Sbjct: 474 QSENDAAKDEVKEVLQALEEL--------------AVNYDQKSQEVEEKSQQNQLLVDEL 519
Query: 230 EKELAERMKNRNAEEELEDLDAVHREEKISLEELRRRHKVLVGEFAQIREEREI 283
+++A + + E EL+ L V ++ + E+ + EF+ I EI
Sbjct: 520 SQKVATML---SLESELQRLQEVSGHQRKRIAEVLNGLMKDLSEFSVIVGNGEI 570
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 50.4 bits (119), Expect = 2e-06
Identities = 74/340 (21%), Positives = 134/340 (39%), Gaps = 35/340 (10%)
Query: 11 LYQAPAINRIGPKTDPSKRPADPLKPLVLSRTKLTTIEAKRIMSILDEAIYK-VELVTLL 69
L + +++ G K P + K L K + + S E YK E VTL
Sbjct: 1490 LQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWK--QVWENMLSSKSKEQQYKDEEEVTLE 1547
Query: 70 SYVASNREDMEGMLGEDVMRAVREHEDLCQVLLENVRCLKEKERQLQEQKEAEEEGWLRD 129
V+ E+ E + E+ EH+ + R EK+R +E+K A+EE L
Sbjct: 1548 EEVSREGEEKEQQVTEEQRHIQEEHK---WARIHRKRARAEKKRAQEERKLAQEEEKLAQ 1604
Query: 130 RLLSIELQKSSLSPLMQQIKDSTKNVLRLLLSNPQAARLLQMQTQGRSAEAQNFIDSLIE 189
+ ++ L+ +I + + + Q L + + S EA+ +
Sbjct: 1605 EERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKK 1664
Query: 190 LRGFLFEKLLTSPMEARDKAQFLQDISR-------QNSNNQQIIDTLEKELAERMKNRNA 242
L +EK+ + K L ++ + +Q +D EKELA+
Sbjct: 1665 LAK-KWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQ------- 1716
Query: 243 EEELEDLDAVHREEKISLEELRRRHKVLVGEFAQIREEREINSKKRMEAEQEMVRMVRAA 302
ELE+L+ E EEL + LV E ++ EE E + +R + +E ++ +
Sbjct: 1717 --ELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEE 1774
Query: 303 TLIQALWKGYLVRSLLRSKKKRGKGKAKDKEKGKQKGKEK 342
L L++ K+K + K K E+ ++ G+++
Sbjct: 1775 EL------------LIQEKEKLAQHKEKMPEEEERLGRKR 1802
Score = 37.7 bits (86), Expect = 0.015
Identities = 24/75 (32%), Positives = 41/75 (54%), Gaps = 5/75 (6%)
Query: 223 QQIIDTLEKELAERMKNRNAEEELEDLDAVHREEKISLEELRRRHKVLVGEFAQIREERE 282
+ ++D LEK+ ++ ++EEE E + REE+ EE R + GE Q+ +E E
Sbjct: 2231 ESLLDELEKQ-----ESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEE 2285
Query: 283 INSKKRMEAEQEMVR 297
KK+ E ++E V+
Sbjct: 2286 EKKKKKKEKKKEEVQ 2300
Score = 35.0 bits (79), Expect = 0.099
Identities = 59/281 (20%), Positives = 115/281 (40%), Gaps = 48/281 (17%)
Query: 48 EAKRIMSILDEAIYKVELVTLLSYVASNREDMEGMLGEDVMRAVREHEDLC--------- 98
+ K + L+E + +E LS+ EG L E+ + E E L
Sbjct: 1710 QEKELAQELEELEWDMEE---LSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEE 1766
Query: 99 --QVLLENVRCLKEKERQLQEQKEAEEE----GWLRDRLLSIELQKSSLSPLMQQIKDST 152
++ E ++EKE+ Q +++ EE G R++L+ +++ + Q ++
Sbjct: 1767 ETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMK-------LAQKRERW 1819
Query: 153 KNVLRLLLSNPQAARLLQMQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFL 212
N + L N +++ Q + + E +N +L L K Q +
Sbjct: 1820 INSMEELTKN----KMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLV 1875
Query: 213 QDISRQNSNNQQIID-----TLEKELAERMKNRNAEEE-----LEDLDAVHREEKISLEE 262
Q ++ N+ + T EKE + K + AE E +ED ++EK++ E+
Sbjct: 1876 QVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVED-SLAKKQEKLAQEK 1934
Query: 263 LR--------RRHKVLVGEFAQIREEREINSKKRMEAEQEM 295
++ + K L GE +EE+ +N + + AE++M
Sbjct: 1935 MKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKM 1975
Score = 34.3 bits (77), Expect = 0.17
Identities = 52/250 (20%), Positives = 101/250 (40%), Gaps = 34/250 (13%)
Query: 99 QVLLENVRCLKEKERQLQEQKEAEEEGWLRDRLLSIELQKSSLSP--LMQQIKDSTKNVL 156
Q L + R L ++E ++ + K A ++++R LSIE K + ++ + TK+
Sbjct: 2081 QKLTRDERKLTQEEIKMTKMKRAL---FVKERRLSIEQSKLDIKEWDFSEKRSELTKDEK 2137
Query: 157 RLLLSNPQAARLLQMQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDIS 216
+L + A ++ + + + + +E + FL+
Sbjct: 2138 KLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRW 2197
Query: 217 RQNSNNQQIIDTLEK---ELAERMKNRNAEEELEDL-DAVHREEKISLEELRRRHKVLVG 272
R+ ++ EK ++ E + EE+E L D + ++E +S EE R +
Sbjct: 2198 RKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEER 2257
Query: 273 EFAQIREEREINSKKRMEAEQEMVRMVRAATLIQALWKGYLVRSLLRSKKKRGKGKAKDK 332
E ++REE E K+ E E++ V +K+ + K K K
Sbjct: 2258 EEEEVREEEE-ERKEEEEGEEKQV------------------------EKEEEEKKKKKK 2292
Query: 333 EKGKQKGKEK 342
EK K++ +EK
Sbjct: 2293 EKKKEEVQEK 2302
Score = 30.8 bits (68), Expect = 1.9
Identities = 32/149 (21%), Positives = 74/149 (49%), Gaps = 10/149 (6%)
Query: 195 FEKLLTSPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNRNAEEELEDLDAVHR 254
F + + S ++ +K + L S + ++ + E+E+ E + R EEE E+ V +
Sbjct: 2226 FSEEMESLLDELEKQESLS--SEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQ-VEK 2282
Query: 255 EEKISLEELRRRHKVLVGEFAQIREER-EINSKKRMEAEQEMVRMVRAATLIQALWKGYL 313
EE+ ++ + + K V E ++ EE+ EI S++ E+ + + +L + + +
Sbjct: 2283 EEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDR--- 2339
Query: 314 VRSLLRSKKKRGKGKAKDKEKGKQKGKEK 342
+ +L KK + K +++ + +G+E+
Sbjct: 2340 EKEIL---KKEKQFKLQEQRRKSLRGRER 2365
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 50.4 bits (119), Expect = 2e-06
Identities = 76/298 (25%), Positives = 134/298 (44%), Gaps = 36/298 (12%)
Query: 70 SYVASNREDMEGMLGEDVMRAVREHE---DLCQVLLENVRCLKEKERQLQEQKEAEEEGW 126
S ++ R+ +E L E +A E E L ++ L+ + + E +L+++++ +E
Sbjct: 1020 SKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELE 1079
Query: 127 LRDRLL---SIELQKSSLSPLMQQIKDSTKNVLRLLLSNPQAARLLQMQTQGRSAEAQNF 183
R L S ELQ+ + QQ + + L QAA L + + +G A AQ
Sbjct: 1080 KLKRRLDGESSELQEQMVE--QQQRAEELRAQLGRKEEELQAA-LARAEDEG-GARAQ-L 1134
Query: 184 IDSLIELRGFLFEKL--LTSPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNRN 241
+ SL E + L E L S AR KA+ +Q + + ++ L EL + + + N
Sbjct: 1135 LKSLREAQAALAEAQEDLESERVARTKAE------KQRRDLGEELEALRGELEDTLDSTN 1188
Query: 242 AEEELED------------LDAVHREEKISLEELRRRHKVLVGEFA----QIREEREINS 285
A++EL L+ R + +++ELR+RH +GE A Q R +
Sbjct: 1189 AQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWE 1248
Query: 286 KKRMEAEQEMVRM-VRAATLIQALWKGYLVRSLLRSKKKRGKGKAKDKEKGKQKGKEK 342
K R+ E E+ + ++L A +G R L + + +G+A D E+ + + EK
Sbjct: 1249 KTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEK 1306
Score = 40.8 bits (94), Expect = 0.002
Identities = 57/265 (21%), Positives = 105/265 (39%), Gaps = 32/265 (12%)
Query: 50 KRIMSILDEAIYKVELVT-LLSYVASNREDMEGMLGED---VMRAVREHEDLCQVLLENV 105
+R+ LD+A +E L+S + + + +L E+ V+RAV E E E
Sbjct: 1448 RRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGRERE 1507
Query: 106 RCLKEKERQLQEQKEAEEEGWLRDRLLSIELQKSSLSPLMQQIKDSTKNVLRLLLSNPQA 165
R L+E++EA EE ++R L EL+ L+ D K+V L +A
Sbjct: 1508 ARALSLTRALEEEQEAREELERQNRALRAELEA-----LLSSKDDVGKSVHEL----ERA 1558
Query: 166 ARLLQMQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNSNNQQI 225
R+ + A+ D L A + A+ +++ Q Q
Sbjct: 1559 CRVAEQAANDLRAQVTELEDELT----------------AAEDAKLRLEVTVQALKTQHE 1602
Query: 226 IDTLEKELAERMKNRNAEEELEDLDAVHREEKISLEELRRRHKVLVGEFAQIREEREINS 285
D ++ A + R ++L D + EE+ K L GE +++ +
Sbjct: 1603 RDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAG 1662
Query: 286 KKRMEAEQEMVRMVRAATLIQALWK 310
+ + EA +++ +M ++ LW+
Sbjct: 1663 QGKEEAVKQLRKM---QAQMKELWR 1684
Score = 36.6 bits (83), Expect = 0.034
Identities = 57/265 (21%), Positives = 113/265 (42%), Gaps = 37/265 (13%)
Query: 76 REDMEGMLG--EDVMRAVREHEDLCQVLLENVRCLKEKERQLQEQKEAEEEGWLRDRLLS 133
R ++E +L +DV ++V E E C+V + L+ + +L+++ A E+ LR
Sbjct: 1535 RAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLR----- 1589
Query: 134 IELQKSSLSPLMQQIKDSTKNVLRLLLSNPQAA--RLLQMQTQGRSAEAQNFIDSLIELR 191
L +Q +K + R L +A R Q+ Q R AE + +
Sbjct: 1590 -------LEVTVQALKTQHE---RDLQGRDEAGEERRRQLAKQLRDAEVERDEE------ 1633
Query: 192 GFLFEKLLTSPMEARDKAQF-LQDISRQNSNNQQIIDTLEKELAE-RMKNRNAEEELEDL 249
K T + AR K + L+++ Q ++ Q + K+L + + + + E+E+
Sbjct: 1634 ----RKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEET 1689
Query: 250 DAVHREEKISLEELRRRHKVLVGEFAQIREEREINSKKRMEAEQEMVRMVRAATLIQALW 309
E E +R K L E +++EE + + R +A+Q+ M +
Sbjct: 1690 RTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMA------DEVA 1743
Query: 310 KGYLVRSLLRSKKKRGKGKAKDKEK 334
G L ++ + +K++ +G+ E+
Sbjct: 1744 NGNLSKAAILEEKRQLEGRLGQLEE 1768
Score = 33.9 bits (76), Expect = 0.22
Identities = 54/226 (23%), Positives = 93/226 (41%), Gaps = 33/226 (14%)
Query: 74 SNREDMEGMLGEDVMRAVREHEDLCQVLLE-NVRCLKEKERQLQEQKEAEEEGWLRDRLL 132
S RE L + + R HE Q L + + + L E QL EQ + W + RL
Sbjct: 1195 SKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQL-EQARRGKGAWEKTRL- 1252
Query: 133 SIELQKSSLSPLMQQIKDSTKNVLRLLLSNPQAARLLQMQ---TQGRSAEAQNFIDSLIE 189
++E + S L + ++ + + Q R L++Q QGR+ + +
Sbjct: 1253 ALEAEVSELRAELSSLQTARQE-------GEQRRRRLELQLQEVQGRAGDGER------- 1298
Query: 190 LRGFLFEKLLTSPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNRNAEEELEDL 249
R EKL + E L+++S + + L KEL+ + E +L D
Sbjct: 1299 ARAEAAEKLQRAQAE-------LENVSGALNEAESKTIRLSKELS------STEAQLHDA 1345
Query: 250 DAVHREEKISLEELRRRHKVLVGEFAQIREEREINSKKRMEAEQEM 295
+ +EE + L R + + E A +RE+ E + R A +E+
Sbjct: 1346 QELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGREL 1391
Score = 32.0 bits (71), Expect = 0.84
Identities = 57/229 (24%), Positives = 94/229 (41%), Gaps = 50/229 (21%)
Query: 73 ASNREDMEGMLGEDVMRAVREHEDLCQV-LLENVRCLKEKERQLQEQKEAEEEG--WLRD 129
AS+R + D M + +L + +LE R L+ + QL+E+ E E+ L D
Sbjct: 1723 ASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLND 1782
Query: 130 RLLSIELQKSSLSPLMQQIKDSTKNVLRLLLSNPQAARLLQMQTQGRSAEAQNFIDSLIE 189
R + LQ SL+ + A R + + + + I E
Sbjct: 1783 RYRKLLLQVESLTTELS------------------AERSFSAKAESGRQQLERQIQ---E 1821
Query: 190 LRGFLFEKLLTSPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNRNAEEELEDL 249
LRG L E+ +A +A+ ++ I LE +LA+ AEE+LE
Sbjct: 1822 LRGRLGEE------DAGARAR-----------HKMTIAALESKLAQ------AEEQLEQE 1858
Query: 250 DAVHREEKISLEELRRRHKVLVGEFAQIREEREINSKKRMEAEQEMVRM 298
RE +S + +RR K L Q+ EER + + R + E+ +R+
Sbjct: 1859 T---RERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRV 1904
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 50.4 bits (119), Expect = 2e-06
Identities = 76/298 (25%), Positives = 134/298 (44%), Gaps = 36/298 (12%)
Query: 70 SYVASNREDMEGMLGEDVMRAVREHE---DLCQVLLENVRCLKEKERQLQEQKEAEEEGW 126
S ++ R+ +E L E +A E E L ++ L+ + + E +L+++++ +E
Sbjct: 1012 SKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELE 1071
Query: 127 LRDRLL---SIELQKSSLSPLMQQIKDSTKNVLRLLLSNPQAARLLQMQTQGRSAEAQNF 183
R L S ELQ+ + QQ + + L QAA L + + +G A AQ
Sbjct: 1072 KLKRRLDGESSELQEQMVE--QQQRAEELRAQLGRKEEELQAA-LARAEDEG-GARAQ-L 1126
Query: 184 IDSLIELRGFLFEKL--LTSPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNRN 241
+ SL E + L E L S AR KA+ +Q + + ++ L EL + + + N
Sbjct: 1127 LKSLREAQAALAEAQEDLESERVARTKAE------KQRRDLGEELEALRGELEDTLDSTN 1180
Query: 242 AEEELED------------LDAVHREEKISLEELRRRHKVLVGEFA----QIREEREINS 285
A++EL L+ R + +++ELR+RH +GE A Q R +
Sbjct: 1181 AQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWE 1240
Query: 286 KKRMEAEQEMVRM-VRAATLIQALWKGYLVRSLLRSKKKRGKGKAKDKEKGKQKGKEK 342
K R+ E E+ + ++L A +G R L + + +G+A D E+ + + EK
Sbjct: 1241 KTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEK 1298
Score = 40.8 bits (94), Expect = 0.002
Identities = 57/265 (21%), Positives = 105/265 (39%), Gaps = 32/265 (12%)
Query: 50 KRIMSILDEAIYKVELVT-LLSYVASNREDMEGMLGED---VMRAVREHEDLCQVLLENV 105
+R+ LD+A +E L+S + + + +L E+ V+RAV E E E
Sbjct: 1440 RRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGRERE 1499
Query: 106 RCLKEKERQLQEQKEAEEEGWLRDRLLSIELQKSSLSPLMQQIKDSTKNVLRLLLSNPQA 165
R L+E++EA EE ++R L EL+ L+ D K+V L +A
Sbjct: 1500 ARALSLTRALEEEQEAREELERQNRALRAELEA-----LLSSKDDVGKSVHEL----ERA 1550
Query: 166 ARLLQMQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNSNNQQI 225
R+ + A+ D L A + A+ +++ Q Q
Sbjct: 1551 CRVAEQAANDLRAQVTELEDELT----------------AAEDAKLRLEVTVQALKTQHE 1594
Query: 226 IDTLEKELAERMKNRNAEEELEDLDAVHREEKISLEELRRRHKVLVGEFAQIREEREINS 285
D ++ A + R ++L D + EE+ K L GE +++ +
Sbjct: 1595 RDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAG 1654
Query: 286 KKRMEAEQEMVRMVRAATLIQALWK 310
+ + EA +++ +M ++ LW+
Sbjct: 1655 QGKEEAVKQLRKM---QAQMKELWR 1676
Score = 36.6 bits (83), Expect = 0.034
Identities = 57/265 (21%), Positives = 113/265 (42%), Gaps = 37/265 (13%)
Query: 76 REDMEGMLG--EDVMRAVREHEDLCQVLLENVRCLKEKERQLQEQKEAEEEGWLRDRLLS 133
R ++E +L +DV ++V E E C+V + L+ + +L+++ A E+ LR
Sbjct: 1527 RAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLR----- 1581
Query: 134 IELQKSSLSPLMQQIKDSTKNVLRLLLSNPQAA--RLLQMQTQGRSAEAQNFIDSLIELR 191
L +Q +K + R L +A R Q+ Q R AE + +
Sbjct: 1582 -------LEVTVQALKTQHE---RDLQGRDEAGEERRRQLAKQLRDAEVERDEE------ 1625
Query: 192 GFLFEKLLTSPMEARDKAQF-LQDISRQNSNNQQIIDTLEKELAE-RMKNRNAEEELEDL 249
K T + AR K + L+++ Q ++ Q + K+L + + + + E+E+
Sbjct: 1626 ----RKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEET 1681
Query: 250 DAVHREEKISLEELRRRHKVLVGEFAQIREEREINSKKRMEAEQEMVRMVRAATLIQALW 309
E E +R K L E +++EE + + R +A+Q+ M +
Sbjct: 1682 RTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMA------DEVA 1735
Query: 310 KGYLVRSLLRSKKKRGKGKAKDKEK 334
G L ++ + +K++ +G+ E+
Sbjct: 1736 NGNLSKAAILEEKRQLEGRLGQLEE 1760
Score = 33.9 bits (76), Expect = 0.22
Identities = 54/226 (23%), Positives = 93/226 (41%), Gaps = 33/226 (14%)
Query: 74 SNREDMEGMLGEDVMRAVREHEDLCQVLLE-NVRCLKEKERQLQEQKEAEEEGWLRDRLL 132
S RE L + + R HE Q L + + + L E QL EQ + W + RL
Sbjct: 1187 SKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQL-EQARRGKGAWEKTRL- 1244
Query: 133 SIELQKSSLSPLMQQIKDSTKNVLRLLLSNPQAARLLQMQ---TQGRSAEAQNFIDSLIE 189
++E + S L + ++ + + Q R L++Q QGR+ + +
Sbjct: 1245 ALEAEVSELRAELSSLQTARQE-------GEQRRRRLELQLQEVQGRAGDGER------- 1290
Query: 190 LRGFLFEKLLTSPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNRNAEEELEDL 249
R EKL + E L+++S + + L KEL+ + E +L D
Sbjct: 1291 ARAEAAEKLQRAQAE-------LENVSGALNEAESKTIRLSKELS------STEAQLHDA 1337
Query: 250 DAVHREEKISLEELRRRHKVLVGEFAQIREEREINSKKRMEAEQEM 295
+ +EE + L R + + E A +RE+ E + R A +E+
Sbjct: 1338 QELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGREL 1383
Score = 32.0 bits (71), Expect = 0.84
Identities = 57/229 (24%), Positives = 94/229 (41%), Gaps = 50/229 (21%)
Query: 73 ASNREDMEGMLGEDVMRAVREHEDLCQV-LLENVRCLKEKERQLQEQKEAEEEG--WLRD 129
AS+R + D M + +L + +LE R L+ + QL+E+ E E+ L D
Sbjct: 1715 ASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLND 1774
Query: 130 RLLSIELQKSSLSPLMQQIKDSTKNVLRLLLSNPQAARLLQMQTQGRSAEAQNFIDSLIE 189
R + LQ SL+ + A R + + + + I E
Sbjct: 1775 RYRKLLLQVESLTTELS------------------AERSFSAKAESGRQQLERQIQ---E 1813
Query: 190 LRGFLFEKLLTSPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNRNAEEELEDL 249
LRG L E+ +A +A+ ++ I LE +LA+ AEE+LE
Sbjct: 1814 LRGRLGEE------DAGARAR-----------HKMTIAALESKLAQ------AEEQLEQE 1850
Query: 250 DAVHREEKISLEELRRRHKVLVGEFAQIREEREINSKKRMEAEQEMVRM 298
RE +S + +RR K L Q+ EER + + R + E+ +R+
Sbjct: 1851 T---RERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRV 1896
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 50.4 bits (119), Expect = 2e-06
Identities = 76/298 (25%), Positives = 134/298 (44%), Gaps = 36/298 (12%)
Query: 70 SYVASNREDMEGMLGEDVMRAVREHE---DLCQVLLENVRCLKEKERQLQEQKEAEEEGW 126
S ++ R+ +E L E +A E E L ++ L+ + + E +L+++++ +E
Sbjct: 1053 SKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELE 1112
Query: 127 LRDRLL---SIELQKSSLSPLMQQIKDSTKNVLRLLLSNPQAARLLQMQTQGRSAEAQNF 183
R L S ELQ+ + QQ + + L QAA L + + +G A AQ
Sbjct: 1113 KLKRRLDGESSELQEQMVE--QQQRAEELRAQLGRKEEELQAA-LARAEDEG-GARAQ-L 1167
Query: 184 IDSLIELRGFLFEKL--LTSPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNRN 241
+ SL E + L E L S AR KA+ +Q + + ++ L EL + + + N
Sbjct: 1168 LKSLREAQAALAEAQEDLESERVARTKAE------KQRRDLGEELEALRGELEDTLDSTN 1221
Query: 242 AEEELED------------LDAVHREEKISLEELRRRHKVLVGEFA----QIREEREINS 285
A++EL L+ R + +++ELR+RH +GE A Q R +
Sbjct: 1222 AQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWE 1281
Query: 286 KKRMEAEQEMVRM-VRAATLIQALWKGYLVRSLLRSKKKRGKGKAKDKEKGKQKGKEK 342
K R+ E E+ + ++L A +G R L + + +G+A D E+ + + EK
Sbjct: 1282 KTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEK 1339
Score = 40.8 bits (94), Expect = 0.002
Identities = 57/265 (21%), Positives = 105/265 (39%), Gaps = 32/265 (12%)
Query: 50 KRIMSILDEAIYKVELVT-LLSYVASNREDMEGMLGED---VMRAVREHEDLCQVLLENV 105
+R+ LD+A +E L+S + + + +L E+ V+RAV E E E
Sbjct: 1481 RRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGRERE 1540
Query: 106 RCLKEKERQLQEQKEAEEEGWLRDRLLSIELQKSSLSPLMQQIKDSTKNVLRLLLSNPQA 165
R L+E++EA EE ++R L EL+ L+ D K+V L +A
Sbjct: 1541 ARALSLTRALEEEQEAREELERQNRALRAELEA-----LLSSKDDVGKSVHEL----ERA 1591
Query: 166 ARLLQMQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNSNNQQI 225
R+ + A+ D L A + A+ +++ Q Q
Sbjct: 1592 CRVAEQAANDLRAQVTELEDELT----------------AAEDAKLRLEVTVQALKTQHE 1635
Query: 226 IDTLEKELAERMKNRNAEEELEDLDAVHREEKISLEELRRRHKVLVGEFAQIREEREINS 285
D ++ A + R ++L D + EE+ K L GE +++ +
Sbjct: 1636 RDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAG 1695
Query: 286 KKRMEAEQEMVRMVRAATLIQALWK 310
+ + EA +++ +M ++ LW+
Sbjct: 1696 QGKEEAVKQLRKM---QAQMKELWR 1717
Score = 36.6 bits (83), Expect = 0.034
Identities = 57/265 (21%), Positives = 113/265 (42%), Gaps = 37/265 (13%)
Query: 76 REDMEGMLG--EDVMRAVREHEDLCQVLLENVRCLKEKERQLQEQKEAEEEGWLRDRLLS 133
R ++E +L +DV ++V E E C+V + L+ + +L+++ A E+ LR
Sbjct: 1568 RAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLR----- 1622
Query: 134 IELQKSSLSPLMQQIKDSTKNVLRLLLSNPQAA--RLLQMQTQGRSAEAQNFIDSLIELR 191
L +Q +K + R L +A R Q+ Q R AE + +
Sbjct: 1623 -------LEVTVQALKTQHE---RDLQGRDEAGEERRRQLAKQLRDAEVERDEE------ 1666
Query: 192 GFLFEKLLTSPMEARDKAQF-LQDISRQNSNNQQIIDTLEKELAE-RMKNRNAEEELEDL 249
K T + AR K + L+++ Q ++ Q + K+L + + + + E+E+
Sbjct: 1667 ----RKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEET 1722
Query: 250 DAVHREEKISLEELRRRHKVLVGEFAQIREEREINSKKRMEAEQEMVRMVRAATLIQALW 309
E E +R K L E +++EE + + R +A+Q+ M +
Sbjct: 1723 RTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMA------DEVA 1776
Query: 310 KGYLVRSLLRSKKKRGKGKAKDKEK 334
G L ++ + +K++ +G+ E+
Sbjct: 1777 NGNLSKAAILEEKRQLEGRLGQLEE 1801
Score = 33.9 bits (76), Expect = 0.22
Identities = 54/226 (23%), Positives = 93/226 (41%), Gaps = 33/226 (14%)
Query: 74 SNREDMEGMLGEDVMRAVREHEDLCQVLLE-NVRCLKEKERQLQEQKEAEEEGWLRDRLL 132
S RE L + + R HE Q L + + + L E QL EQ + W + RL
Sbjct: 1228 SKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQL-EQARRGKGAWEKTRL- 1285
Query: 133 SIELQKSSLSPLMQQIKDSTKNVLRLLLSNPQAARLLQMQ---TQGRSAEAQNFIDSLIE 189
++E + S L + ++ + + Q R L++Q QGR+ + +
Sbjct: 1286 ALEAEVSELRAELSSLQTARQE-------GEQRRRRLELQLQEVQGRAGDGER------- 1331
Query: 190 LRGFLFEKLLTSPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNRNAEEELEDL 249
R EKL + E L+++S + + L KEL+ + E +L D
Sbjct: 1332 ARAEAAEKLQRAQAE-------LENVSGALNEAESKTIRLSKELS------STEAQLHDA 1378
Query: 250 DAVHREEKISLEELRRRHKVLVGEFAQIREEREINSKKRMEAEQEM 295
+ +EE + L R + + E A +RE+ E + R A +E+
Sbjct: 1379 QELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGREL 1424
Score = 32.0 bits (71), Expect = 0.84
Identities = 57/229 (24%), Positives = 94/229 (41%), Gaps = 50/229 (21%)
Query: 73 ASNREDMEGMLGEDVMRAVREHEDLCQV-LLENVRCLKEKERQLQEQKEAEEEG--WLRD 129
AS+R + D M + +L + +LE R L+ + QL+E+ E E+ L D
Sbjct: 1756 ASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLND 1815
Query: 130 RLLSIELQKSSLSPLMQQIKDSTKNVLRLLLSNPQAARLLQMQTQGRSAEAQNFIDSLIE 189
R + LQ SL+ + A R + + + + I E
Sbjct: 1816 RYRKLLLQVESLTTELS------------------AERSFSAKAESGRQQLERQIQ---E 1854
Query: 190 LRGFLFEKLLTSPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNRNAEEELEDL 249
LRG L E+ +A +A+ ++ I LE +LA+ AEE+LE
Sbjct: 1855 LRGRLGEE------DAGARAR-----------HKMTIAALESKLAQ------AEEQLEQE 1891
Query: 250 DAVHREEKISLEELRRRHKVLVGEFAQIREEREINSKKRMEAEQEMVRM 298
RE +S + +RR K L Q+ EER + + R + E+ +R+
Sbjct: 1892 T---RERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRV 1937
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 50.1 bits (118), Expect = 3e-06
Identities = 83/363 (22%), Positives = 153/363 (42%), Gaps = 63/363 (17%)
Query: 19 RIGPKTDPSKRPADPLKPLVLSRTKLTTIEAKRIMSILDEAIYKVELVTLLS-YVASNRE 77
++ P P+K+P K+ + I +D + EL TL S Y+ E
Sbjct: 1292 QLEPVASPAKKP------------KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1339
Query: 78 DMEGMLGEDVM---RAVREHEDLCQV--LLENVRCLKEKERQLQEQKEAEEEGWLRDRL- 131
+ M E+ + + E E L +V LE R L E Q + Q E E + L+ R+
Sbjct: 1340 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKE-LQQRMQ 1398
Query: 132 ----------LSIELQKSSLSPLMQQIKDSTKNVLRLLLSNPQAA-----------RLLQ 170
+ + QK S+ +QQ++ S++ ++ +AA R+++
Sbjct: 1399 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1458
Query: 171 MQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNSNNQQIIDTLE 230
+Q + + L LR E+ +A+++A+ L+ RQ + Q E
Sbjct: 1459 LQLEATERQRGGAEGELQALRA-RAEEAEAQKRQAQEEAERLR---RQVQDESQRKRQAE 1514
Query: 231 KELAERMK--------NRNAEEELED--LDAVHREEKISLEELRRRHKVLVG-EFAQIRE 279
ELA R+K + A + LE+ L A E ++ E+ R +V V E AQ
Sbjct: 1515 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1574
Query: 280 EREINSKKRMEAEQEMVRMVRAATLIQALWKGYLVRSLLRSKKKRGKGKAKDKEKGKQKG 339
E E+ SK+ AE + A L ++L + ++ + LR + +R + + E+ +++
Sbjct: 1575 EAELQSKRASFAE-------KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1627
Query: 340 KEK 342
+ +
Sbjct: 1628 ERE 1630
Score = 41.6 bits (96), Expect = 0.001
Identities = 51/257 (19%), Positives = 109/257 (42%), Gaps = 30/257 (11%)
Query: 55 ILDEAIYKVELVTLLSYVASNREDMEGMLGEDVMRAVREHEDLCQVLLENVRCLK---EK 111
+L E + V+ T L A + + + E R + E + Q L E + + E
Sbjct: 2311 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2370
Query: 112 ERQLQEQKEAEEEGWLRDRLLSIELQKSSLSP------LMQQIKDSTKNVLRLLLSNPQA 165
ERQ Q + AE E R +L E+ ++ +Q ++ + + R L+ +
Sbjct: 2371 ERQRQLEMSAEAE---RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2427
Query: 166 ARLLQ---MQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNSNN 222
L+Q +Q Q +A+ +++ EL R+K + Q+ +
Sbjct: 2428 VTLVQTLEIQRQQSDHDAERLREAIAELE--------------REKEKLQQEAKLLQLKS 2473
Query: 223 QQIIDTLEKELAERMKNRNAEEELEDLDAVHREEKISLEELRRRHKVLVGEFAQIREERE 282
+++ T+++E + + L + D++ + E+ +E + ++ E A+ ++ RE
Sbjct: 2474 EEM-QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2532
Query: 283 INSKKRMEAEQEMVRMV 299
+++ + EQE R+V
Sbjct: 2533 EQQRQQQQMEQERQRLV 2549
Score = 41.6 bits (96), Expect = 0.001
Identities = 45/214 (21%), Positives = 94/214 (43%), Gaps = 13/214 (6%)
Query: 85 EDVMRAVREHEDLCQVLLENVRCLKEKER-----QLQEQKEAEEEGWLRDRLLSIELQKS 139
ED R ++ E++ + L +EK ++Q Q+ + LR+ + +E +K
Sbjct: 2401 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2460
Query: 140 SLSPLMQQIKDSTKNVLRLLLSNPQAARLLQMQTQGRSAEAQNFIDSLIELRGFLFEKLL 199
L + ++ ++ + Q +LLQ +TQ + DSL++ F+ ++
Sbjct: 2461 KLQQEAKLLQLKSEE-----MQTVQQEQLLQ-ETQALQQSFLSEKDSLLQRERFIEQEKA 2514
Query: 200 TSPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKN-RNAEEELEDLDAVHREEKI 258
+D+ Q + + QQ ++ + L M+ R + E E+ +EE
Sbjct: 2515 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2574
Query: 259 SLEELRRRHKVLVGEFAQ-IREEREINSKKRMEA 291
LE+ RR+ + L+ E Q +RE+ ++ ++ A
Sbjct: 2575 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAA 2608
Score = 40.8 bits (94), Expect = 0.002
Identities = 67/264 (25%), Positives = 117/264 (44%), Gaps = 41/264 (15%)
Query: 48 EAKRIMSILDEAIYKVELVTLLSYVASNREDMEGMLGEDVMRAVREHEDLCQVLLENVRC 107
EA R+ ++ +EA + +L A R + E +L E + A+ E ++ E
Sbjct: 1802 EAARLRALAEEAKRQRQLAE--EDAARQRAEAERVLAEK-LAAIGE---ATRLKTEAEIA 1855
Query: 108 LKEKERQLQEQKE-AEEEGWLRDRLLSIELQ-KSSLSPLMQQIKDSTKNVLRLLLSNPQA 165
LKEKE + + + AE+E + R RL Q K+ + + Q++ ++ + L Q
Sbjct: 1856 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER-----QK 1910
Query: 166 ARLLQMQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNSNNQQI 225
+ Q R E + ++ L+ FEK A KA+ ++ R SN +
Sbjct: 1911 GLVEDTLRQRRQVE-----EEILALKAS-FEKA------AAGKAELELELGRIRSNAEDT 1958
Query: 226 IDTLE---------KELA--ERMKNRNAEEELEDLDAVH----REEKISLEELRRRHKVL 270
+ + E ++LA E + R AEE ++ A R+ K +LEE+ R K
Sbjct: 1959 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL-KAK 2017
Query: 271 VGEFAQIREEREINSKKRMEAEQE 294
V E ++RE E S ++++ QE
Sbjct: 2018 VEEARRLRERAEQESARQLQLAQE 2041
Score = 40.8 bits (94), Expect = 0.002
Identities = 67/278 (24%), Positives = 118/278 (42%), Gaps = 44/278 (15%)
Query: 89 RAVREHEDLCQVLLENVRCLKEKERQLQE-QKEAEEEGWLRDRLLSIEL-QKSSLSPLMQ 146
R V E E L Q E + + + ++ +KEAE+E R + L QK + M+
Sbjct: 2109 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2168
Query: 147 QIKDSTKNVLRLLLSNPQAARLLQMQTQGRSAEAQNFIDSLIEL-----------RGFLF 195
+ K + LR Q L++Q + + +N +D ++ R +
Sbjct: 2169 KHKKFAEQTLRQKAQVEQELTTLRLQLE-ETDHQKNLLDEELQRLKAEATEAARQRSQVE 2227
Query: 196 EKLLT--------SPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNRNAEEELE 247
E+L + S ++AR +A+ I R N Q+ + +E AE+MK EE
Sbjct: 2228 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL----QEEAEKMKQ--VAEEAA 2281
Query: 248 DLDAVHREEKISLEELRRRHKVLVGEFAQIREEREINSKKRMEAEQEMVRMVRAATLIQA 307
L ++ +E R ++ + AQ R E K++M+A QE R+ A L+Q
Sbjct: 2282 RLS-------VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2334
Query: 308 LWKGYLVRSLLRSKKKRGKGKAKDKEKGKQKGKEKGKG 345
+ L + + +R +DKE+ Q+ E+ +G
Sbjct: 2335 ------QKELAQEQARR---LQEDKEQMAQQLAEETQG 2363
Score = 37.4 bits (85), Expect = 0.020
Identities = 63/277 (22%), Positives = 113/277 (40%), Gaps = 44/277 (15%)
Query: 91 VREHEDLCQVLLENVRCLKEKERQLQEQKEAEEEGWLRDRLLS---IELQKSSLSPLMQQ 147
V + + L Q E + +E ER+ + + +AEE+ +R R L+ +E Q+ QQ
Sbjct: 1651 VAQQKSLAQAEAEKQK--EEAEREARRRGKAEEQA-VRQRELAEQELEKQRQLAEGTAQQ 1707
Query: 148 IKDSTKNVLRLLLSNPQAAR----------LLQMQTQGRSAEAQNFIDSLIELRGFLFEK 197
+ + ++RL Q + LQ + + + Q L ++R + E
Sbjct: 1708 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM-EV 1766
Query: 198 LLTSPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNRNA-------EEELEDLD 250
LL S A ++++ + S+Q + +ELAE A + +L + D
Sbjct: 1767 LLASKARAEEESRSTSEKSKQRLEAEA---GRFRELAEEAARLRALAEEAKRQRQLAEED 1823
Query: 251 AVHREEKISLEELRRRHKVLVGEFAQIREEREINSKKRMEAEQEMVRMVRAATLIQ---- 306
A ++ E + +GE +++ E EI K++ EAE E +R + Q
Sbjct: 1824 AA--RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK-EAENERLRRLAEDEAFQRRRL 1880
Query: 307 ----ALWKGYLVRSLLRSKKKRGKGKAKDKEKGKQKG 339
A K + L + + KA D E +QKG
Sbjct: 1881 EEQAAQHKADIEERLAQLR------KASDSELERQKG 1911
Score = 35.0 bits (79), Expect = 0.099
Identities = 45/200 (22%), Positives = 86/200 (43%), Gaps = 16/200 (8%)
Query: 103 ENVRCLKEKERQLQEQKEAEEEGWLRDRLLSIELQKSSLSPLMQQIKDSTKNVLRLLLSN 162
E +R + E Q + Q E E ++ + ++ +L L + + + RL +
Sbjct: 1497 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1556
Query: 163 PQAARLLQ--MQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNS 220
+ AR +Q ++T RSAEA+ L R EK +++ + + +
Sbjct: 1557 VERARQVQVALETAQRSAEAE-----LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE 1611
Query: 221 NNQQIIDTLEKELAERMKNRNAEEELEDLDAVHREE---KISLEELRRRHKVLVGEFAQI 277
Q ++ AER + AE ELE E ++ EE+ ++ + E +
Sbjct: 1612 RRAQ-----QQAEAERAREE-AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1665
Query: 278 REEREINSKKRMEAEQEMVR 297
+EE E +++R +AE++ VR
Sbjct: 1666 KEEAEREARRRGKAEEQAVR 1685
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 50.1 bits (118), Expect = 3e-06
Identities = 83/363 (22%), Positives = 153/363 (42%), Gaps = 63/363 (17%)
Query: 19 RIGPKTDPSKRPADPLKPLVLSRTKLTTIEAKRIMSILDEAIYKVELVTLLS-YVASNRE 77
++ P P+K+P K+ + I +D + EL TL S Y+ E
Sbjct: 1296 QLEPVASPAKKP------------KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1343
Query: 78 DMEGMLGEDVM---RAVREHEDLCQV--LLENVRCLKEKERQLQEQKEAEEEGWLRDRL- 131
+ M E+ + + E E L +V LE R L E Q + Q E E + L+ R+
Sbjct: 1344 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKE-LQQRMQ 1402
Query: 132 ----------LSIELQKSSLSPLMQQIKDSTKNVLRLLLSNPQAA-----------RLLQ 170
+ + QK S+ +QQ++ S++ ++ +AA R+++
Sbjct: 1403 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1462
Query: 171 MQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNSNNQQIIDTLE 230
+Q + + L LR E+ +A+++A+ L+ RQ + Q E
Sbjct: 1463 LQLEATERQRGGAEGELQALRA-RAEEAEAQKRQAQEEAERLR---RQVQDESQRKRQAE 1518
Query: 231 KELAERMK--------NRNAEEELED--LDAVHREEKISLEELRRRHKVLVG-EFAQIRE 279
ELA R+K + A + LE+ L A E ++ E+ R +V V E AQ
Sbjct: 1519 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1578
Query: 280 EREINSKKRMEAEQEMVRMVRAATLIQALWKGYLVRSLLRSKKKRGKGKAKDKEKGKQKG 339
E E+ SK+ AE + A L ++L + ++ + LR + +R + + E+ +++
Sbjct: 1579 EAELQSKRASFAE-------KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1631
Query: 340 KEK 342
+ +
Sbjct: 1632 ERE 1634
Score = 41.6 bits (96), Expect = 0.001
Identities = 51/257 (19%), Positives = 109/257 (42%), Gaps = 30/257 (11%)
Query: 55 ILDEAIYKVELVTLLSYVASNREDMEGMLGEDVMRAVREHEDLCQVLLENVRCLK---EK 111
+L E + V+ T L A + + + E R + E + Q L E + + E
Sbjct: 2315 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2374
Query: 112 ERQLQEQKEAEEEGWLRDRLLSIELQKSSLSP------LMQQIKDSTKNVLRLLLSNPQA 165
ERQ Q + AE E R +L E+ ++ +Q ++ + + R L+ +
Sbjct: 2375 ERQRQLEMSAEAE---RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2431
Query: 166 ARLLQ---MQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNSNN 222
L+Q +Q Q +A+ +++ EL R+K + Q+ +
Sbjct: 2432 VTLVQTLEIQRQQSDHDAERLREAIAELE--------------REKEKLQQEAKLLQLKS 2477
Query: 223 QQIIDTLEKELAERMKNRNAEEELEDLDAVHREEKISLEELRRRHKVLVGEFAQIREERE 282
+++ T+++E + + L + D++ + E+ +E + ++ E A+ ++ RE
Sbjct: 2478 EEM-QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2536
Query: 283 INSKKRMEAEQEMVRMV 299
+++ + EQE R+V
Sbjct: 2537 EQQRQQQQMEQERQRLV 2553
Score = 41.6 bits (96), Expect = 0.001
Identities = 45/214 (21%), Positives = 94/214 (43%), Gaps = 13/214 (6%)
Query: 85 EDVMRAVREHEDLCQVLLENVRCLKEKER-----QLQEQKEAEEEGWLRDRLLSIELQKS 139
ED R ++ E++ + L +EK ++Q Q+ + LR+ + +E +K
Sbjct: 2405 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2464
Query: 140 SLSPLMQQIKDSTKNVLRLLLSNPQAARLLQMQTQGRSAEAQNFIDSLIELRGFLFEKLL 199
L + ++ ++ + Q +LLQ +TQ + DSL++ F+ ++
Sbjct: 2465 KLQQEAKLLQLKSEE-----MQTVQQEQLLQ-ETQALQQSFLSEKDSLLQRERFIEQEKA 2518
Query: 200 TSPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKN-RNAEEELEDLDAVHREEKI 258
+D+ Q + + QQ ++ + L M+ R + E E+ +EE
Sbjct: 2519 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2578
Query: 259 SLEELRRRHKVLVGEFAQ-IREEREINSKKRMEA 291
LE+ RR+ + L+ E Q +RE+ ++ ++ A
Sbjct: 2579 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAA 2612
Score = 40.8 bits (94), Expect = 0.002
Identities = 67/264 (25%), Positives = 117/264 (44%), Gaps = 41/264 (15%)
Query: 48 EAKRIMSILDEAIYKVELVTLLSYVASNREDMEGMLGEDVMRAVREHEDLCQVLLENVRC 107
EA R+ ++ +EA + +L A R + E +L E + A+ E ++ E
Sbjct: 1806 EAARLRALAEEAKRQRQLAE--EDAARQRAEAERVLAEK-LAAIGE---ATRLKTEAEIA 1859
Query: 108 LKEKERQLQEQKE-AEEEGWLRDRLLSIELQ-KSSLSPLMQQIKDSTKNVLRLLLSNPQA 165
LKEKE + + + AE+E + R RL Q K+ + + Q++ ++ + L Q
Sbjct: 1860 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER-----QK 1914
Query: 166 ARLLQMQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNSNNQQI 225
+ Q R E + ++ L+ FEK A KA+ ++ R SN +
Sbjct: 1915 GLVEDTLRQRRQVE-----EEILALKAS-FEKA------AAGKAELELELGRIRSNAEDT 1962
Query: 226 IDTLE---------KELA--ERMKNRNAEEELEDLDAVH----REEKISLEELRRRHKVL 270
+ + E ++LA E + R AEE ++ A R+ K +LEE+ R K
Sbjct: 1963 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL-KAK 2021
Query: 271 VGEFAQIREEREINSKKRMEAEQE 294
V E ++RE E S ++++ QE
Sbjct: 2022 VEEARRLRERAEQESARQLQLAQE 2045
Score = 40.8 bits (94), Expect = 0.002
Identities = 67/278 (24%), Positives = 118/278 (42%), Gaps = 44/278 (15%)
Query: 89 RAVREHEDLCQVLLENVRCLKEKERQLQE-QKEAEEEGWLRDRLLSIEL-QKSSLSPLMQ 146
R V E E L Q E + + + ++ +KEAE+E R + L QK + M+
Sbjct: 2113 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2172
Query: 147 QIKDSTKNVLRLLLSNPQAARLLQMQTQGRSAEAQNFIDSLIEL-----------RGFLF 195
+ K + LR Q L++Q + + +N +D ++ R +
Sbjct: 2173 KHKKFAEQTLRQKAQVEQELTTLRLQLE-ETDHQKNLLDEELQRLKAEATEAARQRSQVE 2231
Query: 196 EKLLT--------SPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNRNAEEELE 247
E+L + S ++AR +A+ I R N Q+ + +E AE+MK EE
Sbjct: 2232 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL----QEEAEKMKQ--VAEEAA 2285
Query: 248 DLDAVHREEKISLEELRRRHKVLVGEFAQIREEREINSKKRMEAEQEMVRMVRAATLIQA 307
L ++ +E R ++ + AQ R E K++M+A QE R+ A L+Q
Sbjct: 2286 RLS-------VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2338
Query: 308 LWKGYLVRSLLRSKKKRGKGKAKDKEKGKQKGKEKGKG 345
+ L + + +R +DKE+ Q+ E+ +G
Sbjct: 2339 ------QKELAQEQARR---LQEDKEQMAQQLAEETQG 2367
Score = 37.4 bits (85), Expect = 0.020
Identities = 63/277 (22%), Positives = 113/277 (40%), Gaps = 44/277 (15%)
Query: 91 VREHEDLCQVLLENVRCLKEKERQLQEQKEAEEEGWLRDRLLS---IELQKSSLSPLMQQ 147
V + + L Q E + +E ER+ + + +AEE+ +R R L+ +E Q+ QQ
Sbjct: 1655 VAQQKSLAQAEAEKQK--EEAEREARRRGKAEEQA-VRQRELAEQELEKQRQLAEGTAQQ 1711
Query: 148 IKDSTKNVLRLLLSNPQAAR----------LLQMQTQGRSAEAQNFIDSLIELRGFLFEK 197
+ + ++RL Q + LQ + + + Q L ++R + E
Sbjct: 1712 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM-EV 1770
Query: 198 LLTSPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNRNA-------EEELEDLD 250
LL S A ++++ + S+Q + +ELAE A + +L + D
Sbjct: 1771 LLASKARAEEESRSTSEKSKQRLEAEA---GRFRELAEEAARLRALAEEAKRQRQLAEED 1827
Query: 251 AVHREEKISLEELRRRHKVLVGEFAQIREEREINSKKRMEAEQEMVRMVRAATLIQ---- 306
A ++ E + +GE +++ E EI K++ EAE E +R + Q
Sbjct: 1828 AA--RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK-EAENERLRRLAEDEAFQRRRL 1884
Query: 307 ----ALWKGYLVRSLLRSKKKRGKGKAKDKEKGKQKG 339
A K + L + + KA D E +QKG
Sbjct: 1885 EEQAAQHKADIEERLAQLR------KASDSELERQKG 1915
Score = 35.0 bits (79), Expect = 0.099
Identities = 45/200 (22%), Positives = 86/200 (43%), Gaps = 16/200 (8%)
Query: 103 ENVRCLKEKERQLQEQKEAEEEGWLRDRLLSIELQKSSLSPLMQQIKDSTKNVLRLLLSN 162
E +R + E Q + Q E E ++ + ++ +L L + + + RL +
Sbjct: 1501 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1560
Query: 163 PQAARLLQ--MQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNS 220
+ AR +Q ++T RSAEA+ L R EK +++ + + +
Sbjct: 1561 VERARQVQVALETAQRSAEAE-----LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE 1615
Query: 221 NNQQIIDTLEKELAERMKNRNAEEELEDLDAVHREE---KISLEELRRRHKVLVGEFAQI 277
Q ++ AER + AE ELE E ++ EE+ ++ + E +
Sbjct: 1616 RRAQ-----QQAEAERAREE-AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1669
Query: 278 REEREINSKKRMEAEQEMVR 297
+EE E +++R +AE++ VR
Sbjct: 1670 KEEAEREARRRGKAEEQAVR 1689
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 50.1 bits (118), Expect = 3e-06
Identities = 83/363 (22%), Positives = 153/363 (42%), Gaps = 63/363 (17%)
Query: 19 RIGPKTDPSKRPADPLKPLVLSRTKLTTIEAKRIMSILDEAIYKVELVTLLS-YVASNRE 77
++ P P+K+P K+ + I +D + EL TL S Y+ E
Sbjct: 1292 QLEPVASPAKKP------------KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1339
Query: 78 DMEGMLGEDVM---RAVREHEDLCQV--LLENVRCLKEKERQLQEQKEAEEEGWLRDRL- 131
+ M E+ + + E E L +V LE R L E Q + Q E E + L+ R+
Sbjct: 1340 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKE-LQQRMQ 1398
Query: 132 ----------LSIELQKSSLSPLMQQIKDSTKNVLRLLLSNPQAA-----------RLLQ 170
+ + QK S+ +QQ++ S++ ++ +AA R+++
Sbjct: 1399 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1458
Query: 171 MQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNSNNQQIIDTLE 230
+Q + + L LR E+ +A+++A+ L+ RQ + Q E
Sbjct: 1459 LQLEATERQRGGAEGELQALRA-RAEEAEAQKRQAQEEAERLR---RQVQDESQRKRQAE 1514
Query: 231 KELAERMK--------NRNAEEELED--LDAVHREEKISLEELRRRHKVLVG-EFAQIRE 279
ELA R+K + A + LE+ L A E ++ E+ R +V V E AQ
Sbjct: 1515 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1574
Query: 280 EREINSKKRMEAEQEMVRMVRAATLIQALWKGYLVRSLLRSKKKRGKGKAKDKEKGKQKG 339
E E+ SK+ AE + A L ++L + ++ + LR + +R + + E+ +++
Sbjct: 1575 EAELQSKRASFAE-------KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1627
Query: 340 KEK 342
+ +
Sbjct: 1628 ERE 1630
Score = 41.6 bits (96), Expect = 0.001
Identities = 51/257 (19%), Positives = 109/257 (42%), Gaps = 30/257 (11%)
Query: 55 ILDEAIYKVELVTLLSYVASNREDMEGMLGEDVMRAVREHEDLCQVLLENVRCLK---EK 111
+L E + V+ T L A + + + E R + E + Q L E + + E
Sbjct: 2311 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2370
Query: 112 ERQLQEQKEAEEEGWLRDRLLSIELQKSSLSP------LMQQIKDSTKNVLRLLLSNPQA 165
ERQ Q + AE E R +L E+ ++ +Q ++ + + R L+ +
Sbjct: 2371 ERQRQLEMSAEAE---RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2427
Query: 166 ARLLQ---MQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNSNN 222
L+Q +Q Q +A+ +++ EL R+K + Q+ +
Sbjct: 2428 VTLVQTLEIQRQQSDHDAERLREAIAELE--------------REKEKLQQEAKLLQLKS 2473
Query: 223 QQIIDTLEKELAERMKNRNAEEELEDLDAVHREEKISLEELRRRHKVLVGEFAQIREERE 282
+++ T+++E + + L + D++ + E+ +E + ++ E A+ ++ RE
Sbjct: 2474 EEM-QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2532
Query: 283 INSKKRMEAEQEMVRMV 299
+++ + EQE R+V
Sbjct: 2533 EQQRQQQQMEQERQRLV 2549
Score = 41.6 bits (96), Expect = 0.001
Identities = 45/214 (21%), Positives = 94/214 (43%), Gaps = 13/214 (6%)
Query: 85 EDVMRAVREHEDLCQVLLENVRCLKEKER-----QLQEQKEAEEEGWLRDRLLSIELQKS 139
ED R ++ E++ + L +EK ++Q Q+ + LR+ + +E +K
Sbjct: 2401 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2460
Query: 140 SLSPLMQQIKDSTKNVLRLLLSNPQAARLLQMQTQGRSAEAQNFIDSLIELRGFLFEKLL 199
L + ++ ++ + Q +LLQ +TQ + DSL++ F+ ++
Sbjct: 2461 KLQQEAKLLQLKSEE-----MQTVQQEQLLQ-ETQALQQSFLSEKDSLLQRERFIEQEKA 2514
Query: 200 TSPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKN-RNAEEELEDLDAVHREEKI 258
+D+ Q + + QQ ++ + L M+ R + E E+ +EE
Sbjct: 2515 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2574
Query: 259 SLEELRRRHKVLVGEFAQ-IREEREINSKKRMEA 291
LE+ RR+ + L+ E Q +RE+ ++ ++ A
Sbjct: 2575 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAA 2608
Score = 40.8 bits (94), Expect = 0.002
Identities = 67/264 (25%), Positives = 117/264 (44%), Gaps = 41/264 (15%)
Query: 48 EAKRIMSILDEAIYKVELVTLLSYVASNREDMEGMLGEDVMRAVREHEDLCQVLLENVRC 107
EA R+ ++ +EA + +L A R + E +L E + A+ E ++ E
Sbjct: 1802 EAARLRALAEEAKRQRQLAE--EDAARQRAEAERVLAEK-LAAIGE---ATRLKTEAEIA 1855
Query: 108 LKEKERQLQEQKE-AEEEGWLRDRLLSIELQ-KSSLSPLMQQIKDSTKNVLRLLLSNPQA 165
LKEKE + + + AE+E + R RL Q K+ + + Q++ ++ + L Q
Sbjct: 1856 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER-----QK 1910
Query: 166 ARLLQMQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNSNNQQI 225
+ Q R E + ++ L+ FEK A KA+ ++ R SN +
Sbjct: 1911 GLVEDTLRQRRQVE-----EEILALKAS-FEKA------AAGKAELELELGRIRSNAEDT 1958
Query: 226 IDTLE---------KELA--ERMKNRNAEEELEDLDAVH----REEKISLEELRRRHKVL 270
+ + E ++LA E + R AEE ++ A R+ K +LEE+ R K
Sbjct: 1959 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL-KAK 2017
Query: 271 VGEFAQIREEREINSKKRMEAEQE 294
V E ++RE E S ++++ QE
Sbjct: 2018 VEEARRLRERAEQESARQLQLAQE 2041
Score = 40.8 bits (94), Expect = 0.002
Identities = 67/278 (24%), Positives = 118/278 (42%), Gaps = 44/278 (15%)
Query: 89 RAVREHEDLCQVLLENVRCLKEKERQLQE-QKEAEEEGWLRDRLLSIEL-QKSSLSPLMQ 146
R V E E L Q E + + + ++ +KEAE+E R + L QK + M+
Sbjct: 2109 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2168
Query: 147 QIKDSTKNVLRLLLSNPQAARLLQMQTQGRSAEAQNFIDSLIEL-----------RGFLF 195
+ K + LR Q L++Q + + +N +D ++ R +
Sbjct: 2169 KHKKFAEQTLRQKAQVEQELTTLRLQLE-ETDHQKNLLDEELQRLKAEATEAARQRSQVE 2227
Query: 196 EKLLT--------SPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNRNAEEELE 247
E+L + S ++AR +A+ I R N Q+ + +E AE+MK EE
Sbjct: 2228 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL----QEEAEKMKQ--VAEEAA 2281
Query: 248 DLDAVHREEKISLEELRRRHKVLVGEFAQIREEREINSKKRMEAEQEMVRMVRAATLIQA 307
L ++ +E R ++ + AQ R E K++M+A QE R+ A L+Q
Sbjct: 2282 RLS-------VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2334
Query: 308 LWKGYLVRSLLRSKKKRGKGKAKDKEKGKQKGKEKGKG 345
+ L + + +R +DKE+ Q+ E+ +G
Sbjct: 2335 ------QKELAQEQARR---LQEDKEQMAQQLAEETQG 2363
Score = 37.4 bits (85), Expect = 0.020
Identities = 63/277 (22%), Positives = 113/277 (40%), Gaps = 44/277 (15%)
Query: 91 VREHEDLCQVLLENVRCLKEKERQLQEQKEAEEEGWLRDRLLS---IELQKSSLSPLMQQ 147
V + + L Q E + +E ER+ + + +AEE+ +R R L+ +E Q+ QQ
Sbjct: 1651 VAQQKSLAQAEAEKQK--EEAEREARRRGKAEEQA-VRQRELAEQELEKQRQLAEGTAQQ 1707
Query: 148 IKDSTKNVLRLLLSNPQAAR----------LLQMQTQGRSAEAQNFIDSLIELRGFLFEK 197
+ + ++RL Q + LQ + + + Q L ++R + E
Sbjct: 1708 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM-EV 1766
Query: 198 LLTSPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNRNA-------EEELEDLD 250
LL S A ++++ + S+Q + +ELAE A + +L + D
Sbjct: 1767 LLASKARAEEESRSTSEKSKQRLEAEA---GRFRELAEEAARLRALAEEAKRQRQLAEED 1823
Query: 251 AVHREEKISLEELRRRHKVLVGEFAQIREEREINSKKRMEAEQEMVRMVRAATLIQ---- 306
A ++ E + +GE +++ E EI K++ EAE E +R + Q
Sbjct: 1824 AA--RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK-EAENERLRRLAEDEAFQRRRL 1880
Query: 307 ----ALWKGYLVRSLLRSKKKRGKGKAKDKEKGKQKG 339
A K + L + + KA D E +QKG
Sbjct: 1881 EEQAAQHKADIEERLAQLR------KASDSELERQKG 1911
Score = 35.0 bits (79), Expect = 0.099
Identities = 45/200 (22%), Positives = 86/200 (43%), Gaps = 16/200 (8%)
Query: 103 ENVRCLKEKERQLQEQKEAEEEGWLRDRLLSIELQKSSLSPLMQQIKDSTKNVLRLLLSN 162
E +R + E Q + Q E E ++ + ++ +L L + + + RL +
Sbjct: 1497 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1556
Query: 163 PQAARLLQ--MQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNS 220
+ AR +Q ++T RSAEA+ L R EK +++ + + +
Sbjct: 1557 VERARQVQVALETAQRSAEAE-----LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE 1611
Query: 221 NNQQIIDTLEKELAERMKNRNAEEELEDLDAVHREE---KISLEELRRRHKVLVGEFAQI 277
Q ++ AER + AE ELE E ++ EE+ ++ + E +
Sbjct: 1612 RRAQ-----QQAEAERAREE-AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1665
Query: 278 REEREINSKKRMEAEQEMVR 297
+EE E +++R +AE++ VR
Sbjct: 1666 KEEAEREARRRGKAEEQAVR 1685
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 50.1 bits (118), Expect = 3e-06
Identities = 83/363 (22%), Positives = 153/363 (42%), Gaps = 63/363 (17%)
Query: 19 RIGPKTDPSKRPADPLKPLVLSRTKLTTIEAKRIMSILDEAIYKVELVTLLS-YVASNRE 77
++ P P+K+P K+ + I +D + EL TL S Y+ E
Sbjct: 1260 QLEPVASPAKKP------------KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1307
Query: 78 DMEGMLGEDVM---RAVREHEDLCQV--LLENVRCLKEKERQLQEQKEAEEEGWLRDRL- 131
+ M E+ + + E E L +V LE R L E Q + Q E E + L+ R+
Sbjct: 1308 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKE-LQQRMQ 1366
Query: 132 ----------LSIELQKSSLSPLMQQIKDSTKNVLRLLLSNPQAA-----------RLLQ 170
+ + QK S+ +QQ++ S++ ++ +AA R+++
Sbjct: 1367 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1426
Query: 171 MQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNSNNQQIIDTLE 230
+Q + + L LR E+ +A+++A+ L+ RQ + Q E
Sbjct: 1427 LQLEATERQRGGAEGELQALRA-RAEEAEAQKRQAQEEAERLR---RQVQDESQRKRQAE 1482
Query: 231 KELAERMK--------NRNAEEELED--LDAVHREEKISLEELRRRHKVLVG-EFAQIRE 279
ELA R+K + A + LE+ L A E ++ E+ R +V V E AQ
Sbjct: 1483 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1542
Query: 280 EREINSKKRMEAEQEMVRMVRAATLIQALWKGYLVRSLLRSKKKRGKGKAKDKEKGKQKG 339
E E+ SK+ AE + A L ++L + ++ + LR + +R + + E+ +++
Sbjct: 1543 EAELQSKRASFAE-------KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1595
Query: 340 KEK 342
+ +
Sbjct: 1596 ERE 1598
Score = 41.6 bits (96), Expect = 0.001
Identities = 51/257 (19%), Positives = 109/257 (42%), Gaps = 30/257 (11%)
Query: 55 ILDEAIYKVELVTLLSYVASNREDMEGMLGEDVMRAVREHEDLCQVLLENVRCLK---EK 111
+L E + V+ T L A + + + E R + E + Q L E + + E
Sbjct: 2279 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2338
Query: 112 ERQLQEQKEAEEEGWLRDRLLSIELQKSSLSP------LMQQIKDSTKNVLRLLLSNPQA 165
ERQ Q + AE E R +L E+ ++ +Q ++ + + R L+ +
Sbjct: 2339 ERQRQLEMSAEAE---RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2395
Query: 166 ARLLQ---MQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNSNN 222
L+Q +Q Q +A+ +++ EL R+K + Q+ +
Sbjct: 2396 VTLVQTLEIQRQQSDHDAERLREAIAELE--------------REKEKLQQEAKLLQLKS 2441
Query: 223 QQIIDTLEKELAERMKNRNAEEELEDLDAVHREEKISLEELRRRHKVLVGEFAQIREERE 282
+++ T+++E + + L + D++ + E+ +E + ++ E A+ ++ RE
Sbjct: 2442 EEM-QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2500
Query: 283 INSKKRMEAEQEMVRMV 299
+++ + EQE R+V
Sbjct: 2501 EQQRQQQQMEQERQRLV 2517
Score = 41.6 bits (96), Expect = 0.001
Identities = 45/214 (21%), Positives = 94/214 (43%), Gaps = 13/214 (6%)
Query: 85 EDVMRAVREHEDLCQVLLENVRCLKEKER-----QLQEQKEAEEEGWLRDRLLSIELQKS 139
ED R ++ E++ + L +EK ++Q Q+ + LR+ + +E +K
Sbjct: 2369 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2428
Query: 140 SLSPLMQQIKDSTKNVLRLLLSNPQAARLLQMQTQGRSAEAQNFIDSLIELRGFLFEKLL 199
L + ++ ++ + Q +LLQ +TQ + DSL++ F+ ++
Sbjct: 2429 KLQQEAKLLQLKSEE-----MQTVQQEQLLQ-ETQALQQSFLSEKDSLLQRERFIEQEKA 2482
Query: 200 TSPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKN-RNAEEELEDLDAVHREEKI 258
+D+ Q + + QQ ++ + L M+ R + E E+ +EE
Sbjct: 2483 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2542
Query: 259 SLEELRRRHKVLVGEFAQ-IREEREINSKKRMEA 291
LE+ RR+ + L+ E Q +RE+ ++ ++ A
Sbjct: 2543 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAA 2576
Score = 40.8 bits (94), Expect = 0.002
Identities = 67/264 (25%), Positives = 117/264 (44%), Gaps = 41/264 (15%)
Query: 48 EAKRIMSILDEAIYKVELVTLLSYVASNREDMEGMLGEDVMRAVREHEDLCQVLLENVRC 107
EA R+ ++ +EA + +L A R + E +L E + A+ E ++ E
Sbjct: 1770 EAARLRALAEEAKRQRQLAE--EDAARQRAEAERVLAEK-LAAIGE---ATRLKTEAEIA 1823
Query: 108 LKEKERQLQEQKE-AEEEGWLRDRLLSIELQ-KSSLSPLMQQIKDSTKNVLRLLLSNPQA 165
LKEKE + + + AE+E + R RL Q K+ + + Q++ ++ + L Q
Sbjct: 1824 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER-----QK 1878
Query: 166 ARLLQMQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNSNNQQI 225
+ Q R E + ++ L+ FEK A KA+ ++ R SN +
Sbjct: 1879 GLVEDTLRQRRQVE-----EEILALKAS-FEKA------AAGKAELELELGRIRSNAEDT 1926
Query: 226 IDTLE---------KELA--ERMKNRNAEEELEDLDAVH----REEKISLEELRRRHKVL 270
+ + E ++LA E + R AEE ++ A R+ K +LEE+ R K
Sbjct: 1927 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL-KAK 1985
Query: 271 VGEFAQIREEREINSKKRMEAEQE 294
V E ++RE E S ++++ QE
Sbjct: 1986 VEEARRLRERAEQESARQLQLAQE 2009
Score = 40.8 bits (94), Expect = 0.002
Identities = 67/278 (24%), Positives = 118/278 (42%), Gaps = 44/278 (15%)
Query: 89 RAVREHEDLCQVLLENVRCLKEKERQLQE-QKEAEEEGWLRDRLLSIEL-QKSSLSPLMQ 146
R V E E L Q E + + + ++ +KEAE+E R + L QK + M+
Sbjct: 2077 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2136
Query: 147 QIKDSTKNVLRLLLSNPQAARLLQMQTQGRSAEAQNFIDSLIEL-----------RGFLF 195
+ K + LR Q L++Q + + +N +D ++ R +
Sbjct: 2137 KHKKFAEQTLRQKAQVEQELTTLRLQLE-ETDHQKNLLDEELQRLKAEATEAARQRSQVE 2195
Query: 196 EKLLT--------SPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNRNAEEELE 247
E+L + S ++AR +A+ I R N Q+ + +E AE+MK EE
Sbjct: 2196 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL----QEEAEKMKQ--VAEEAA 2249
Query: 248 DLDAVHREEKISLEELRRRHKVLVGEFAQIREEREINSKKRMEAEQEMVRMVRAATLIQA 307
L ++ +E R ++ + AQ R E K++M+A QE R+ A L+Q
Sbjct: 2250 RLS-------VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2302
Query: 308 LWKGYLVRSLLRSKKKRGKGKAKDKEKGKQKGKEKGKG 345
+ L + + +R +DKE+ Q+ E+ +G
Sbjct: 2303 ------QKELAQEQARR---LQEDKEQMAQQLAEETQG 2331
Score = 37.4 bits (85), Expect = 0.020
Identities = 63/277 (22%), Positives = 113/277 (40%), Gaps = 44/277 (15%)
Query: 91 VREHEDLCQVLLENVRCLKEKERQLQEQKEAEEEGWLRDRLLS---IELQKSSLSPLMQQ 147
V + + L Q E + +E ER+ + + +AEE+ +R R L+ +E Q+ QQ
Sbjct: 1619 VAQQKSLAQAEAEKQK--EEAEREARRRGKAEEQA-VRQRELAEQELEKQRQLAEGTAQQ 1675
Query: 148 IKDSTKNVLRLLLSNPQAAR----------LLQMQTQGRSAEAQNFIDSLIELRGFLFEK 197
+ + ++RL Q + LQ + + + Q L ++R + E
Sbjct: 1676 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM-EV 1734
Query: 198 LLTSPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNRNA-------EEELEDLD 250
LL S A ++++ + S+Q + +ELAE A + +L + D
Sbjct: 1735 LLASKARAEEESRSTSEKSKQRLEAEA---GRFRELAEEAARLRALAEEAKRQRQLAEED 1791
Query: 251 AVHREEKISLEELRRRHKVLVGEFAQIREEREINSKKRMEAEQEMVRMVRAATLIQ---- 306
A ++ E + +GE +++ E EI K++ EAE E +R + Q
Sbjct: 1792 AA--RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK-EAENERLRRLAEDEAFQRRRL 1848
Query: 307 ----ALWKGYLVRSLLRSKKKRGKGKAKDKEKGKQKG 339
A K + L + + KA D E +QKG
Sbjct: 1849 EEQAAQHKADIEERLAQLR------KASDSELERQKG 1879
Score = 35.0 bits (79), Expect = 0.099
Identities = 45/200 (22%), Positives = 86/200 (43%), Gaps = 16/200 (8%)
Query: 103 ENVRCLKEKERQLQEQKEAEEEGWLRDRLLSIELQKSSLSPLMQQIKDSTKNVLRLLLSN 162
E +R + E Q + Q E E ++ + ++ +L L + + + RL +
Sbjct: 1465 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1524
Query: 163 PQAARLLQ--MQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNS 220
+ AR +Q ++T RSAEA+ L R EK +++ + + +
Sbjct: 1525 VERARQVQVALETAQRSAEAE-----LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE 1579
Query: 221 NNQQIIDTLEKELAERMKNRNAEEELEDLDAVHREE---KISLEELRRRHKVLVGEFAQI 277
Q ++ AER + AE ELE E ++ EE+ ++ + E +
Sbjct: 1580 RRAQ-----QQAEAERAREE-AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1633
Query: 278 REEREINSKKRMEAEQEMVR 297
+EE E +++R +AE++ VR
Sbjct: 1634 KEEAEREARRRGKAEEQAVR 1653
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 50.1 bits (118), Expect = 3e-06
Identities = 83/363 (22%), Positives = 153/363 (42%), Gaps = 63/363 (17%)
Query: 19 RIGPKTDPSKRPADPLKPLVLSRTKLTTIEAKRIMSILDEAIYKVELVTLLS-YVASNRE 77
++ P P+K+P K+ + I +D + EL TL S Y+ E
Sbjct: 1429 QLEPVASPAKKP------------KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1476
Query: 78 DMEGMLGEDVM---RAVREHEDLCQV--LLENVRCLKEKERQLQEQKEAEEEGWLRDRL- 131
+ M E+ + + E E L +V LE R L E Q + Q E E + L+ R+
Sbjct: 1477 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKE-LQQRMQ 1535
Query: 132 ----------LSIELQKSSLSPLMQQIKDSTKNVLRLLLSNPQAA-----------RLLQ 170
+ + QK S+ +QQ++ S++ ++ +AA R+++
Sbjct: 1536 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1595
Query: 171 MQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNSNNQQIIDTLE 230
+Q + + L LR E+ +A+++A+ L+ RQ + Q E
Sbjct: 1596 LQLEATERQRGGAEGELQALRA-RAEEAEAQKRQAQEEAERLR---RQVQDESQRKRQAE 1651
Query: 231 KELAERMK--------NRNAEEELED--LDAVHREEKISLEELRRRHKVLVG-EFAQIRE 279
ELA R+K + A + LE+ L A E ++ E+ R +V V E AQ
Sbjct: 1652 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1711
Query: 280 EREINSKKRMEAEQEMVRMVRAATLIQALWKGYLVRSLLRSKKKRGKGKAKDKEKGKQKG 339
E E+ SK+ AE + A L ++L + ++ + LR + +R + + E+ +++
Sbjct: 1712 EAELQSKRASFAE-------KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1764
Query: 340 KEK 342
+ +
Sbjct: 1765 ERE 1767
Score = 41.6 bits (96), Expect = 0.001
Identities = 51/257 (19%), Positives = 109/257 (42%), Gaps = 30/257 (11%)
Query: 55 ILDEAIYKVELVTLLSYVASNREDMEGMLGEDVMRAVREHEDLCQVLLENVRCLK---EK 111
+L E + V+ T L A + + + E R + E + Q L E + + E
Sbjct: 2448 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2507
Query: 112 ERQLQEQKEAEEEGWLRDRLLSIELQKSSLSP------LMQQIKDSTKNVLRLLLSNPQA 165
ERQ Q + AE E R +L E+ ++ +Q ++ + + R L+ +
Sbjct: 2508 ERQRQLEMSAEAE---RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2564
Query: 166 ARLLQ---MQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNSNN 222
L+Q +Q Q +A+ +++ EL R+K + Q+ +
Sbjct: 2565 VTLVQTLEIQRQQSDHDAERLREAIAELE--------------REKEKLQQEAKLLQLKS 2610
Query: 223 QQIIDTLEKELAERMKNRNAEEELEDLDAVHREEKISLEELRRRHKVLVGEFAQIREERE 282
+++ T+++E + + L + D++ + E+ +E + ++ E A+ ++ RE
Sbjct: 2611 EEM-QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2669
Query: 283 INSKKRMEAEQEMVRMV 299
+++ + EQE R+V
Sbjct: 2670 EQQRQQQQMEQERQRLV 2686
Score = 41.6 bits (96), Expect = 0.001
Identities = 45/214 (21%), Positives = 94/214 (43%), Gaps = 13/214 (6%)
Query: 85 EDVMRAVREHEDLCQVLLENVRCLKEKER-----QLQEQKEAEEEGWLRDRLLSIELQKS 139
ED R ++ E++ + L +EK ++Q Q+ + LR+ + +E +K
Sbjct: 2538 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2597
Query: 140 SLSPLMQQIKDSTKNVLRLLLSNPQAARLLQMQTQGRSAEAQNFIDSLIELRGFLFEKLL 199
L + ++ ++ + Q +LLQ +TQ + DSL++ F+ ++
Sbjct: 2598 KLQQEAKLLQLKSEE-----MQTVQQEQLLQ-ETQALQQSFLSEKDSLLQRERFIEQEKA 2651
Query: 200 TSPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKN-RNAEEELEDLDAVHREEKI 258
+D+ Q + + QQ ++ + L M+ R + E E+ +EE
Sbjct: 2652 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2711
Query: 259 SLEELRRRHKVLVGEFAQ-IREEREINSKKRMEA 291
LE+ RR+ + L+ E Q +RE+ ++ ++ A
Sbjct: 2712 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAA 2745
Score = 40.8 bits (94), Expect = 0.002
Identities = 67/264 (25%), Positives = 117/264 (44%), Gaps = 41/264 (15%)
Query: 48 EAKRIMSILDEAIYKVELVTLLSYVASNREDMEGMLGEDVMRAVREHEDLCQVLLENVRC 107
EA R+ ++ +EA + +L A R + E +L E + A+ E ++ E
Sbjct: 1939 EAARLRALAEEAKRQRQLAE--EDAARQRAEAERVLAEK-LAAIGE---ATRLKTEAEIA 1992
Query: 108 LKEKERQLQEQKE-AEEEGWLRDRLLSIELQ-KSSLSPLMQQIKDSTKNVLRLLLSNPQA 165
LKEKE + + + AE+E + R RL Q K+ + + Q++ ++ + L Q
Sbjct: 1993 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER-----QK 2047
Query: 166 ARLLQMQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNSNNQQI 225
+ Q R E + ++ L+ FEK A KA+ ++ R SN +
Sbjct: 2048 GLVEDTLRQRRQVE-----EEILALKAS-FEKA------AAGKAELELELGRIRSNAEDT 2095
Query: 226 IDTLE---------KELA--ERMKNRNAEEELEDLDAVH----REEKISLEELRRRHKVL 270
+ + E ++LA E + R AEE ++ A R+ K +LEE+ R K
Sbjct: 2096 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL-KAK 2154
Query: 271 VGEFAQIREEREINSKKRMEAEQE 294
V E ++RE E S ++++ QE
Sbjct: 2155 VEEARRLRERAEQESARQLQLAQE 2178
Score = 40.8 bits (94), Expect = 0.002
Identities = 67/278 (24%), Positives = 118/278 (42%), Gaps = 44/278 (15%)
Query: 89 RAVREHEDLCQVLLENVRCLKEKERQLQE-QKEAEEEGWLRDRLLSIEL-QKSSLSPLMQ 146
R V E E L Q E + + + ++ +KEAE+E R + L QK + M+
Sbjct: 2246 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2305
Query: 147 QIKDSTKNVLRLLLSNPQAARLLQMQTQGRSAEAQNFIDSLIEL-----------RGFLF 195
+ K + LR Q L++Q + + +N +D ++ R +
Sbjct: 2306 KHKKFAEQTLRQKAQVEQELTTLRLQLE-ETDHQKNLLDEELQRLKAEATEAARQRSQVE 2364
Query: 196 EKLLT--------SPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNRNAEEELE 247
E+L + S ++AR +A+ I R N Q+ + +E AE+MK EE
Sbjct: 2365 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL----QEEAEKMKQ--VAEEAA 2418
Query: 248 DLDAVHREEKISLEELRRRHKVLVGEFAQIREEREINSKKRMEAEQEMVRMVRAATLIQA 307
L ++ +E R ++ + AQ R E K++M+A QE R+ A L+Q
Sbjct: 2419 RLS-------VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2471
Query: 308 LWKGYLVRSLLRSKKKRGKGKAKDKEKGKQKGKEKGKG 345
+ L + + +R +DKE+ Q+ E+ +G
Sbjct: 2472 ------QKELAQEQARR---LQEDKEQMAQQLAEETQG 2500
Score = 37.4 bits (85), Expect = 0.020
Identities = 63/277 (22%), Positives = 113/277 (40%), Gaps = 44/277 (15%)
Query: 91 VREHEDLCQVLLENVRCLKEKERQLQEQKEAEEEGWLRDRLLS---IELQKSSLSPLMQQ 147
V + + L Q E + +E ER+ + + +AEE+ +R R L+ +E Q+ QQ
Sbjct: 1788 VAQQKSLAQAEAEKQK--EEAEREARRRGKAEEQA-VRQRELAEQELEKQRQLAEGTAQQ 1844
Query: 148 IKDSTKNVLRLLLSNPQAAR----------LLQMQTQGRSAEAQNFIDSLIELRGFLFEK 197
+ + ++RL Q + LQ + + + Q L ++R + E
Sbjct: 1845 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM-EV 1903
Query: 198 LLTSPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNRNA-------EEELEDLD 250
LL S A ++++ + S+Q + +ELAE A + +L + D
Sbjct: 1904 LLASKARAEEESRSTSEKSKQRLEAEA---GRFRELAEEAARLRALAEEAKRQRQLAEED 1960
Query: 251 AVHREEKISLEELRRRHKVLVGEFAQIREEREINSKKRMEAEQEMVRMVRAATLIQ---- 306
A ++ E + +GE +++ E EI K++ EAE E +R + Q
Sbjct: 1961 AA--RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK-EAENERLRRLAEDEAFQRRRL 2017
Query: 307 ----ALWKGYLVRSLLRSKKKRGKGKAKDKEKGKQKG 339
A K + L + + KA D E +QKG
Sbjct: 2018 EEQAAQHKADIEERLAQLR------KASDSELERQKG 2048
Score = 35.0 bits (79), Expect = 0.099
Identities = 45/200 (22%), Positives = 86/200 (43%), Gaps = 16/200 (8%)
Query: 103 ENVRCLKEKERQLQEQKEAEEEGWLRDRLLSIELQKSSLSPLMQQIKDSTKNVLRLLLSN 162
E +R + E Q + Q E E ++ + ++ +L L + + + RL +
Sbjct: 1634 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1693
Query: 163 PQAARLLQ--MQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNS 220
+ AR +Q ++T RSAEA+ L R EK +++ + + +
Sbjct: 1694 VERARQVQVALETAQRSAEAE-----LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE 1748
Query: 221 NNQQIIDTLEKELAERMKNRNAEEELEDLDAVHREE---KISLEELRRRHKVLVGEFAQI 277
Q ++ AER + AE ELE E ++ EE+ ++ + E +
Sbjct: 1749 RRAQ-----QQAEAERAREE-AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1802
Query: 278 REEREINSKKRMEAEQEMVR 297
+EE E +++R +AE++ VR
Sbjct: 1803 KEEAEREARRRGKAEEQAVR 1822
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 50.1 bits (118), Expect = 3e-06
Identities = 83/363 (22%), Positives = 153/363 (42%), Gaps = 63/363 (17%)
Query: 19 RIGPKTDPSKRPADPLKPLVLSRTKLTTIEAKRIMSILDEAIYKVELVTLLS-YVASNRE 77
++ P P+K+P K+ + I +D + EL TL S Y+ E
Sbjct: 1270 QLEPVASPAKKP------------KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1317
Query: 78 DMEGMLGEDVM---RAVREHEDLCQV--LLENVRCLKEKERQLQEQKEAEEEGWLRDRL- 131
+ M E+ + + E E L +V LE R L E Q + Q E E + L+ R+
Sbjct: 1318 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKE-LQQRMQ 1376
Query: 132 ----------LSIELQKSSLSPLMQQIKDSTKNVLRLLLSNPQAA-----------RLLQ 170
+ + QK S+ +QQ++ S++ ++ +AA R+++
Sbjct: 1377 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1436
Query: 171 MQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNSNNQQIIDTLE 230
+Q + + L LR E+ +A+++A+ L+ RQ + Q E
Sbjct: 1437 LQLEATERQRGGAEGELQALRA-RAEEAEAQKRQAQEEAERLR---RQVQDESQRKRQAE 1492
Query: 231 KELAERMK--------NRNAEEELED--LDAVHREEKISLEELRRRHKVLVG-EFAQIRE 279
ELA R+K + A + LE+ L A E ++ E+ R +V V E AQ
Sbjct: 1493 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1552
Query: 280 EREINSKKRMEAEQEMVRMVRAATLIQALWKGYLVRSLLRSKKKRGKGKAKDKEKGKQKG 339
E E+ SK+ AE + A L ++L + ++ + LR + +R + + E+ +++
Sbjct: 1553 EAELQSKRASFAE-------KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1605
Query: 340 KEK 342
+ +
Sbjct: 1606 ERE 1608
Score = 41.6 bits (96), Expect = 0.001
Identities = 51/257 (19%), Positives = 109/257 (42%), Gaps = 30/257 (11%)
Query: 55 ILDEAIYKVELVTLLSYVASNREDMEGMLGEDVMRAVREHEDLCQVLLENVRCLK---EK 111
+L E + V+ T L A + + + E R + E + Q L E + + E
Sbjct: 2289 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2348
Query: 112 ERQLQEQKEAEEEGWLRDRLLSIELQKSSLSP------LMQQIKDSTKNVLRLLLSNPQA 165
ERQ Q + AE E R +L E+ ++ +Q ++ + + R L+ +
Sbjct: 2349 ERQRQLEMSAEAE---RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2405
Query: 166 ARLLQ---MQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNSNN 222
L+Q +Q Q +A+ +++ EL R+K + Q+ +
Sbjct: 2406 VTLVQTLEIQRQQSDHDAERLREAIAELE--------------REKEKLQQEAKLLQLKS 2451
Query: 223 QQIIDTLEKELAERMKNRNAEEELEDLDAVHREEKISLEELRRRHKVLVGEFAQIREERE 282
+++ T+++E + + L + D++ + E+ +E + ++ E A+ ++ RE
Sbjct: 2452 EEM-QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2510
Query: 283 INSKKRMEAEQEMVRMV 299
+++ + EQE R+V
Sbjct: 2511 EQQRQQQQMEQERQRLV 2527
Score = 41.6 bits (96), Expect = 0.001
Identities = 45/214 (21%), Positives = 94/214 (43%), Gaps = 13/214 (6%)
Query: 85 EDVMRAVREHEDLCQVLLENVRCLKEKER-----QLQEQKEAEEEGWLRDRLLSIELQKS 139
ED R ++ E++ + L +EK ++Q Q+ + LR+ + +E +K
Sbjct: 2379 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2438
Query: 140 SLSPLMQQIKDSTKNVLRLLLSNPQAARLLQMQTQGRSAEAQNFIDSLIELRGFLFEKLL 199
L + ++ ++ + Q +LLQ +TQ + DSL++ F+ ++
Sbjct: 2439 KLQQEAKLLQLKSEE-----MQTVQQEQLLQ-ETQALQQSFLSEKDSLLQRERFIEQEKA 2492
Query: 200 TSPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKN-RNAEEELEDLDAVHREEKI 258
+D+ Q + + QQ ++ + L M+ R + E E+ +EE
Sbjct: 2493 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2552
Query: 259 SLEELRRRHKVLVGEFAQ-IREEREINSKKRMEA 291
LE+ RR+ + L+ E Q +RE+ ++ ++ A
Sbjct: 2553 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAA 2586
Score = 40.8 bits (94), Expect = 0.002
Identities = 67/264 (25%), Positives = 117/264 (44%), Gaps = 41/264 (15%)
Query: 48 EAKRIMSILDEAIYKVELVTLLSYVASNREDMEGMLGEDVMRAVREHEDLCQVLLENVRC 107
EA R+ ++ +EA + +L A R + E +L E + A+ E ++ E
Sbjct: 1780 EAARLRALAEEAKRQRQLAE--EDAARQRAEAERVLAEK-LAAIGE---ATRLKTEAEIA 1833
Query: 108 LKEKERQLQEQKE-AEEEGWLRDRLLSIELQ-KSSLSPLMQQIKDSTKNVLRLLLSNPQA 165
LKEKE + + + AE+E + R RL Q K+ + + Q++ ++ + L Q
Sbjct: 1834 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER-----QK 1888
Query: 166 ARLLQMQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNSNNQQI 225
+ Q R E + ++ L+ FEK A KA+ ++ R SN +
Sbjct: 1889 GLVEDTLRQRRQVE-----EEILALKAS-FEKA------AAGKAELELELGRIRSNAEDT 1936
Query: 226 IDTLE---------KELA--ERMKNRNAEEELEDLDAVH----REEKISLEELRRRHKVL 270
+ + E ++LA E + R AEE ++ A R+ K +LEE+ R K
Sbjct: 1937 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL-KAK 1995
Query: 271 VGEFAQIREEREINSKKRMEAEQE 294
V E ++RE E S ++++ QE
Sbjct: 1996 VEEARRLRERAEQESARQLQLAQE 2019
Score = 40.8 bits (94), Expect = 0.002
Identities = 67/278 (24%), Positives = 118/278 (42%), Gaps = 44/278 (15%)
Query: 89 RAVREHEDLCQVLLENVRCLKEKERQLQE-QKEAEEEGWLRDRLLSIEL-QKSSLSPLMQ 146
R V E E L Q E + + + ++ +KEAE+E R + L QK + M+
Sbjct: 2087 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2146
Query: 147 QIKDSTKNVLRLLLSNPQAARLLQMQTQGRSAEAQNFIDSLIEL-----------RGFLF 195
+ K + LR Q L++Q + + +N +D ++ R +
Sbjct: 2147 KHKKFAEQTLRQKAQVEQELTTLRLQLE-ETDHQKNLLDEELQRLKAEATEAARQRSQVE 2205
Query: 196 EKLLT--------SPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNRNAEEELE 247
E+L + S ++AR +A+ I R N Q+ + +E AE+MK EE
Sbjct: 2206 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL----QEEAEKMKQ--VAEEAA 2259
Query: 248 DLDAVHREEKISLEELRRRHKVLVGEFAQIREEREINSKKRMEAEQEMVRMVRAATLIQA 307
L ++ +E R ++ + AQ R E K++M+A QE R+ A L+Q
Sbjct: 2260 RLS-------VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2312
Query: 308 LWKGYLVRSLLRSKKKRGKGKAKDKEKGKQKGKEKGKG 345
+ L + + +R +DKE+ Q+ E+ +G
Sbjct: 2313 ------QKELAQEQARR---LQEDKEQMAQQLAEETQG 2341
Score = 37.4 bits (85), Expect = 0.020
Identities = 63/277 (22%), Positives = 113/277 (40%), Gaps = 44/277 (15%)
Query: 91 VREHEDLCQVLLENVRCLKEKERQLQEQKEAEEEGWLRDRLLS---IELQKSSLSPLMQQ 147
V + + L Q E + +E ER+ + + +AEE+ +R R L+ +E Q+ QQ
Sbjct: 1629 VAQQKSLAQAEAEKQK--EEAEREARRRGKAEEQA-VRQRELAEQELEKQRQLAEGTAQQ 1685
Query: 148 IKDSTKNVLRLLLSNPQAAR----------LLQMQTQGRSAEAQNFIDSLIELRGFLFEK 197
+ + ++RL Q + LQ + + + Q L ++R + E
Sbjct: 1686 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM-EV 1744
Query: 198 LLTSPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNRNA-------EEELEDLD 250
LL S A ++++ + S+Q + +ELAE A + +L + D
Sbjct: 1745 LLASKARAEEESRSTSEKSKQRLEAEA---GRFRELAEEAARLRALAEEAKRQRQLAEED 1801
Query: 251 AVHREEKISLEELRRRHKVLVGEFAQIREEREINSKKRMEAEQEMVRMVRAATLIQ---- 306
A ++ E + +GE +++ E EI K++ EAE E +R + Q
Sbjct: 1802 AA--RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK-EAENERLRRLAEDEAFQRRRL 1858
Query: 307 ----ALWKGYLVRSLLRSKKKRGKGKAKDKEKGKQKG 339
A K + L + + KA D E +QKG
Sbjct: 1859 EEQAAQHKADIEERLAQLR------KASDSELERQKG 1889
Score = 35.0 bits (79), Expect = 0.099
Identities = 45/200 (22%), Positives = 86/200 (43%), Gaps = 16/200 (8%)
Query: 103 ENVRCLKEKERQLQEQKEAEEEGWLRDRLLSIELQKSSLSPLMQQIKDSTKNVLRLLLSN 162
E +R + E Q + Q E E ++ + ++ +L L + + + RL +
Sbjct: 1475 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1534
Query: 163 PQAARLLQ--MQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNS 220
+ AR +Q ++T RSAEA+ L R EK +++ + + +
Sbjct: 1535 VERARQVQVALETAQRSAEAE-----LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE 1589
Query: 221 NNQQIIDTLEKELAERMKNRNAEEELEDLDAVHREE---KISLEELRRRHKVLVGEFAQI 277
Q ++ AER + AE ELE E ++ EE+ ++ + E +
Sbjct: 1590 RRAQ-----QQAEAERAREE-AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1643
Query: 278 REEREINSKKRMEAEQEMVR 297
+EE E +++R +AE++ VR
Sbjct: 1644 KEEAEREARRRGKAEEQAVR 1663
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 50.1 bits (118), Expect = 3e-06
Identities = 83/363 (22%), Positives = 153/363 (42%), Gaps = 63/363 (17%)
Query: 19 RIGPKTDPSKRPADPLKPLVLSRTKLTTIEAKRIMSILDEAIYKVELVTLLS-YVASNRE 77
++ P P+K+P K+ + I +D + EL TL S Y+ E
Sbjct: 1278 QLEPVASPAKKP------------KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1325
Query: 78 DMEGMLGEDVM---RAVREHEDLCQV--LLENVRCLKEKERQLQEQKEAEEEGWLRDRL- 131
+ M E+ + + E E L +V LE R L E Q + Q E E + L+ R+
Sbjct: 1326 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKE-LQQRMQ 1384
Query: 132 ----------LSIELQKSSLSPLMQQIKDSTKNVLRLLLSNPQAA-----------RLLQ 170
+ + QK S+ +QQ++ S++ ++ +AA R+++
Sbjct: 1385 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1444
Query: 171 MQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNSNNQQIIDTLE 230
+Q + + L LR E+ +A+++A+ L+ RQ + Q E
Sbjct: 1445 LQLEATERQRGGAEGELQALRA-RAEEAEAQKRQAQEEAERLR---RQVQDESQRKRQAE 1500
Query: 231 KELAERMK--------NRNAEEELED--LDAVHREEKISLEELRRRHKVLVG-EFAQIRE 279
ELA R+K + A + LE+ L A E ++ E+ R +V V E AQ
Sbjct: 1501 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1560
Query: 280 EREINSKKRMEAEQEMVRMVRAATLIQALWKGYLVRSLLRSKKKRGKGKAKDKEKGKQKG 339
E E+ SK+ AE + A L ++L + ++ + LR + +R + + E+ +++
Sbjct: 1561 EAELQSKRASFAE-------KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1613
Query: 340 KEK 342
+ +
Sbjct: 1614 ERE 1616
Score = 41.6 bits (96), Expect = 0.001
Identities = 51/257 (19%), Positives = 109/257 (42%), Gaps = 30/257 (11%)
Query: 55 ILDEAIYKVELVTLLSYVASNREDMEGMLGEDVMRAVREHEDLCQVLLENVRCLK---EK 111
+L E + V+ T L A + + + E R + E + Q L E + + E
Sbjct: 2297 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2356
Query: 112 ERQLQEQKEAEEEGWLRDRLLSIELQKSSLSP------LMQQIKDSTKNVLRLLLSNPQA 165
ERQ Q + AE E R +L E+ ++ +Q ++ + + R L+ +
Sbjct: 2357 ERQRQLEMSAEAE---RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2413
Query: 166 ARLLQ---MQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNSNN 222
L+Q +Q Q +A+ +++ EL R+K + Q+ +
Sbjct: 2414 VTLVQTLEIQRQQSDHDAERLREAIAELE--------------REKEKLQQEAKLLQLKS 2459
Query: 223 QQIIDTLEKELAERMKNRNAEEELEDLDAVHREEKISLEELRRRHKVLVGEFAQIREERE 282
+++ T+++E + + L + D++ + E+ +E + ++ E A+ ++ RE
Sbjct: 2460 EEM-QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2518
Query: 283 INSKKRMEAEQEMVRMV 299
+++ + EQE R+V
Sbjct: 2519 EQQRQQQQMEQERQRLV 2535
Score = 41.6 bits (96), Expect = 0.001
Identities = 45/214 (21%), Positives = 94/214 (43%), Gaps = 13/214 (6%)
Query: 85 EDVMRAVREHEDLCQVLLENVRCLKEKER-----QLQEQKEAEEEGWLRDRLLSIELQKS 139
ED R ++ E++ + L +EK ++Q Q+ + LR+ + +E +K
Sbjct: 2387 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2446
Query: 140 SLSPLMQQIKDSTKNVLRLLLSNPQAARLLQMQTQGRSAEAQNFIDSLIELRGFLFEKLL 199
L + ++ ++ + Q +LLQ +TQ + DSL++ F+ ++
Sbjct: 2447 KLQQEAKLLQLKSEE-----MQTVQQEQLLQ-ETQALQQSFLSEKDSLLQRERFIEQEKA 2500
Query: 200 TSPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKN-RNAEEELEDLDAVHREEKI 258
+D+ Q + + QQ ++ + L M+ R + E E+ +EE
Sbjct: 2501 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2560
Query: 259 SLEELRRRHKVLVGEFAQ-IREEREINSKKRMEA 291
LE+ RR+ + L+ E Q +RE+ ++ ++ A
Sbjct: 2561 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAA 2594
Score = 40.8 bits (94), Expect = 0.002
Identities = 67/264 (25%), Positives = 117/264 (44%), Gaps = 41/264 (15%)
Query: 48 EAKRIMSILDEAIYKVELVTLLSYVASNREDMEGMLGEDVMRAVREHEDLCQVLLENVRC 107
EA R+ ++ +EA + +L A R + E +L E + A+ E ++ E
Sbjct: 1788 EAARLRALAEEAKRQRQLAE--EDAARQRAEAERVLAEK-LAAIGE---ATRLKTEAEIA 1841
Query: 108 LKEKERQLQEQKE-AEEEGWLRDRLLSIELQ-KSSLSPLMQQIKDSTKNVLRLLLSNPQA 165
LKEKE + + + AE+E + R RL Q K+ + + Q++ ++ + L Q
Sbjct: 1842 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER-----QK 1896
Query: 166 ARLLQMQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNSNNQQI 225
+ Q R E + ++ L+ FEK A KA+ ++ R SN +
Sbjct: 1897 GLVEDTLRQRRQVE-----EEILALKAS-FEKA------AAGKAELELELGRIRSNAEDT 1944
Query: 226 IDTLE---------KELA--ERMKNRNAEEELEDLDAVH----REEKISLEELRRRHKVL 270
+ + E ++LA E + R AEE ++ A R+ K +LEE+ R K
Sbjct: 1945 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL-KAK 2003
Query: 271 VGEFAQIREEREINSKKRMEAEQE 294
V E ++RE E S ++++ QE
Sbjct: 2004 VEEARRLRERAEQESARQLQLAQE 2027
Score = 40.8 bits (94), Expect = 0.002
Identities = 67/278 (24%), Positives = 118/278 (42%), Gaps = 44/278 (15%)
Query: 89 RAVREHEDLCQVLLENVRCLKEKERQLQE-QKEAEEEGWLRDRLLSIEL-QKSSLSPLMQ 146
R V E E L Q E + + + ++ +KEAE+E R + L QK + M+
Sbjct: 2095 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2154
Query: 147 QIKDSTKNVLRLLLSNPQAARLLQMQTQGRSAEAQNFIDSLIEL-----------RGFLF 195
+ K + LR Q L++Q + + +N +D ++ R +
Sbjct: 2155 KHKKFAEQTLRQKAQVEQELTTLRLQLE-ETDHQKNLLDEELQRLKAEATEAARQRSQVE 2213
Query: 196 EKLLT--------SPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNRNAEEELE 247
E+L + S ++AR +A+ I R N Q+ + +E AE+MK EE
Sbjct: 2214 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL----QEEAEKMKQ--VAEEAA 2267
Query: 248 DLDAVHREEKISLEELRRRHKVLVGEFAQIREEREINSKKRMEAEQEMVRMVRAATLIQA 307
L ++ +E R ++ + AQ R E K++M+A QE R+ A L+Q
Sbjct: 2268 RLS-------VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2320
Query: 308 LWKGYLVRSLLRSKKKRGKGKAKDKEKGKQKGKEKGKG 345
+ L + + +R +DKE+ Q+ E+ +G
Sbjct: 2321 ------QKELAQEQARR---LQEDKEQMAQQLAEETQG 2349
Score = 37.4 bits (85), Expect = 0.020
Identities = 63/277 (22%), Positives = 113/277 (40%), Gaps = 44/277 (15%)
Query: 91 VREHEDLCQVLLENVRCLKEKERQLQEQKEAEEEGWLRDRLLS---IELQKSSLSPLMQQ 147
V + + L Q E + +E ER+ + + +AEE+ +R R L+ +E Q+ QQ
Sbjct: 1637 VAQQKSLAQAEAEKQK--EEAEREARRRGKAEEQA-VRQRELAEQELEKQRQLAEGTAQQ 1693
Query: 148 IKDSTKNVLRLLLSNPQAAR----------LLQMQTQGRSAEAQNFIDSLIELRGFLFEK 197
+ + ++RL Q + LQ + + + Q L ++R + E
Sbjct: 1694 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM-EV 1752
Query: 198 LLTSPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNRNA-------EEELEDLD 250
LL S A ++++ + S+Q + +ELAE A + +L + D
Sbjct: 1753 LLASKARAEEESRSTSEKSKQRLEAEA---GRFRELAEEAARLRALAEEAKRQRQLAEED 1809
Query: 251 AVHREEKISLEELRRRHKVLVGEFAQIREEREINSKKRMEAEQEMVRMVRAATLIQ---- 306
A ++ E + +GE +++ E EI K++ EAE E +R + Q
Sbjct: 1810 AA--RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK-EAENERLRRLAEDEAFQRRRL 1866
Query: 307 ----ALWKGYLVRSLLRSKKKRGKGKAKDKEKGKQKG 339
A K + L + + KA D E +QKG
Sbjct: 1867 EEQAAQHKADIEERLAQLR------KASDSELERQKG 1897
Score = 35.0 bits (79), Expect = 0.099
Identities = 45/200 (22%), Positives = 86/200 (43%), Gaps = 16/200 (8%)
Query: 103 ENVRCLKEKERQLQEQKEAEEEGWLRDRLLSIELQKSSLSPLMQQIKDSTKNVLRLLLSN 162
E +R + E Q + Q E E ++ + ++ +L L + + + RL +
Sbjct: 1483 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1542
Query: 163 PQAARLLQ--MQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNS 220
+ AR +Q ++T RSAEA+ L R EK +++ + + +
Sbjct: 1543 VERARQVQVALETAQRSAEAE-----LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE 1597
Query: 221 NNQQIIDTLEKELAERMKNRNAEEELEDLDAVHREE---KISLEELRRRHKVLVGEFAQI 277
Q ++ AER + AE ELE E ++ EE+ ++ + E +
Sbjct: 1598 RRAQ-----QQAEAERAREE-AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1651
Query: 278 REEREINSKKRMEAEQEMVR 297
+EE E +++R +AE++ VR
Sbjct: 1652 KEEAEREARRRGKAEEQAVR 1671
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 50.1 bits (118), Expect = 3e-06
Identities = 83/363 (22%), Positives = 153/363 (42%), Gaps = 63/363 (17%)
Query: 19 RIGPKTDPSKRPADPLKPLVLSRTKLTTIEAKRIMSILDEAIYKVELVTLLS-YVASNRE 77
++ P P+K+P K+ + I +D + EL TL S Y+ E
Sbjct: 1319 QLEPVASPAKKP------------KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1366
Query: 78 DMEGMLGEDVM---RAVREHEDLCQV--LLENVRCLKEKERQLQEQKEAEEEGWLRDRL- 131
+ M E+ + + E E L +V LE R L E Q + Q E E + L+ R+
Sbjct: 1367 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKE-LQQRMQ 1425
Query: 132 ----------LSIELQKSSLSPLMQQIKDSTKNVLRLLLSNPQAA-----------RLLQ 170
+ + QK S+ +QQ++ S++ ++ +AA R+++
Sbjct: 1426 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1485
Query: 171 MQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNSNNQQIIDTLE 230
+Q + + L LR E+ +A+++A+ L+ RQ + Q E
Sbjct: 1486 LQLEATERQRGGAEGELQALRA-RAEEAEAQKRQAQEEAERLR---RQVQDESQRKRQAE 1541
Query: 231 KELAERMK--------NRNAEEELED--LDAVHREEKISLEELRRRHKVLVG-EFAQIRE 279
ELA R+K + A + LE+ L A E ++ E+ R +V V E AQ
Sbjct: 1542 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1601
Query: 280 EREINSKKRMEAEQEMVRMVRAATLIQALWKGYLVRSLLRSKKKRGKGKAKDKEKGKQKG 339
E E+ SK+ AE + A L ++L + ++ + LR + +R + + E+ +++
Sbjct: 1602 EAELQSKRASFAE-------KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1654
Query: 340 KEK 342
+ +
Sbjct: 1655 ERE 1657
Score = 41.6 bits (96), Expect = 0.001
Identities = 51/257 (19%), Positives = 109/257 (42%), Gaps = 30/257 (11%)
Query: 55 ILDEAIYKVELVTLLSYVASNREDMEGMLGEDVMRAVREHEDLCQVLLENVRCLK---EK 111
+L E + V+ T L A + + + E R + E + Q L E + + E
Sbjct: 2338 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2397
Query: 112 ERQLQEQKEAEEEGWLRDRLLSIELQKSSLSP------LMQQIKDSTKNVLRLLLSNPQA 165
ERQ Q + AE E R +L E+ ++ +Q ++ + + R L+ +
Sbjct: 2398 ERQRQLEMSAEAE---RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2454
Query: 166 ARLLQ---MQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNSNN 222
L+Q +Q Q +A+ +++ EL R+K + Q+ +
Sbjct: 2455 VTLVQTLEIQRQQSDHDAERLREAIAELE--------------REKEKLQQEAKLLQLKS 2500
Query: 223 QQIIDTLEKELAERMKNRNAEEELEDLDAVHREEKISLEELRRRHKVLVGEFAQIREERE 282
+++ T+++E + + L + D++ + E+ +E + ++ E A+ ++ RE
Sbjct: 2501 EEM-QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2559
Query: 283 INSKKRMEAEQEMVRMV 299
+++ + EQE R+V
Sbjct: 2560 EQQRQQQQMEQERQRLV 2576
Score = 41.6 bits (96), Expect = 0.001
Identities = 45/214 (21%), Positives = 94/214 (43%), Gaps = 13/214 (6%)
Query: 85 EDVMRAVREHEDLCQVLLENVRCLKEKER-----QLQEQKEAEEEGWLRDRLLSIELQKS 139
ED R ++ E++ + L +EK ++Q Q+ + LR+ + +E +K
Sbjct: 2428 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2487
Query: 140 SLSPLMQQIKDSTKNVLRLLLSNPQAARLLQMQTQGRSAEAQNFIDSLIELRGFLFEKLL 199
L + ++ ++ + Q +LLQ +TQ + DSL++ F+ ++
Sbjct: 2488 KLQQEAKLLQLKSEE-----MQTVQQEQLLQ-ETQALQQSFLSEKDSLLQRERFIEQEKA 2541
Query: 200 TSPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKN-RNAEEELEDLDAVHREEKI 258
+D+ Q + + QQ ++ + L M+ R + E E+ +EE
Sbjct: 2542 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2601
Query: 259 SLEELRRRHKVLVGEFAQ-IREEREINSKKRMEA 291
LE+ RR+ + L+ E Q +RE+ ++ ++ A
Sbjct: 2602 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAA 2635
Score = 40.8 bits (94), Expect = 0.002
Identities = 67/264 (25%), Positives = 117/264 (44%), Gaps = 41/264 (15%)
Query: 48 EAKRIMSILDEAIYKVELVTLLSYVASNREDMEGMLGEDVMRAVREHEDLCQVLLENVRC 107
EA R+ ++ +EA + +L A R + E +L E + A+ E ++ E
Sbjct: 1829 EAARLRALAEEAKRQRQLAE--EDAARQRAEAERVLAEK-LAAIGE---ATRLKTEAEIA 1882
Query: 108 LKEKERQLQEQKE-AEEEGWLRDRLLSIELQ-KSSLSPLMQQIKDSTKNVLRLLLSNPQA 165
LKEKE + + + AE+E + R RL Q K+ + + Q++ ++ + L Q
Sbjct: 1883 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER-----QK 1937
Query: 166 ARLLQMQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNSNNQQI 225
+ Q R E + ++ L+ FEK A KA+ ++ R SN +
Sbjct: 1938 GLVEDTLRQRRQVE-----EEILALKAS-FEKA------AAGKAELELELGRIRSNAEDT 1985
Query: 226 IDTLE---------KELA--ERMKNRNAEEELEDLDAVH----REEKISLEELRRRHKVL 270
+ + E ++LA E + R AEE ++ A R+ K +LEE+ R K
Sbjct: 1986 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL-KAK 2044
Query: 271 VGEFAQIREEREINSKKRMEAEQE 294
V E ++RE E S ++++ QE
Sbjct: 2045 VEEARRLRERAEQESARQLQLAQE 2068
Score = 40.8 bits (94), Expect = 0.002
Identities = 67/278 (24%), Positives = 118/278 (42%), Gaps = 44/278 (15%)
Query: 89 RAVREHEDLCQVLLENVRCLKEKERQLQE-QKEAEEEGWLRDRLLSIEL-QKSSLSPLMQ 146
R V E E L Q E + + + ++ +KEAE+E R + L QK + M+
Sbjct: 2136 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2195
Query: 147 QIKDSTKNVLRLLLSNPQAARLLQMQTQGRSAEAQNFIDSLIEL-----------RGFLF 195
+ K + LR Q L++Q + + +N +D ++ R +
Sbjct: 2196 KHKKFAEQTLRQKAQVEQELTTLRLQLE-ETDHQKNLLDEELQRLKAEATEAARQRSQVE 2254
Query: 196 EKLLT--------SPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNRNAEEELE 247
E+L + S ++AR +A+ I R N Q+ + +E AE+MK EE
Sbjct: 2255 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL----QEEAEKMKQ--VAEEAA 2308
Query: 248 DLDAVHREEKISLEELRRRHKVLVGEFAQIREEREINSKKRMEAEQEMVRMVRAATLIQA 307
L ++ +E R ++ + AQ R E K++M+A QE R+ A L+Q
Sbjct: 2309 RLS-------VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2361
Query: 308 LWKGYLVRSLLRSKKKRGKGKAKDKEKGKQKGKEKGKG 345
+ L + + +R +DKE+ Q+ E+ +G
Sbjct: 2362 ------QKELAQEQARR---LQEDKEQMAQQLAEETQG 2390
Score = 37.4 bits (85), Expect = 0.020
Identities = 63/277 (22%), Positives = 113/277 (40%), Gaps = 44/277 (15%)
Query: 91 VREHEDLCQVLLENVRCLKEKERQLQEQKEAEEEGWLRDRLLS---IELQKSSLSPLMQQ 147
V + + L Q E + +E ER+ + + +AEE+ +R R L+ +E Q+ QQ
Sbjct: 1678 VAQQKSLAQAEAEKQK--EEAEREARRRGKAEEQA-VRQRELAEQELEKQRQLAEGTAQQ 1734
Query: 148 IKDSTKNVLRLLLSNPQAAR----------LLQMQTQGRSAEAQNFIDSLIELRGFLFEK 197
+ + ++RL Q + LQ + + + Q L ++R + E
Sbjct: 1735 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM-EV 1793
Query: 198 LLTSPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNRNA-------EEELEDLD 250
LL S A ++++ + S+Q + +ELAE A + +L + D
Sbjct: 1794 LLASKARAEEESRSTSEKSKQRLEAEA---GRFRELAEEAARLRALAEEAKRQRQLAEED 1850
Query: 251 AVHREEKISLEELRRRHKVLVGEFAQIREEREINSKKRMEAEQEMVRMVRAATLIQ---- 306
A ++ E + +GE +++ E EI K++ EAE E +R + Q
Sbjct: 1851 AA--RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK-EAENERLRRLAEDEAFQRRRL 1907
Query: 307 ----ALWKGYLVRSLLRSKKKRGKGKAKDKEKGKQKG 339
A K + L + + KA D E +QKG
Sbjct: 1908 EEQAAQHKADIEERLAQLR------KASDSELERQKG 1938
Score = 35.0 bits (79), Expect = 0.099
Identities = 45/200 (22%), Positives = 86/200 (43%), Gaps = 16/200 (8%)
Query: 103 ENVRCLKEKERQLQEQKEAEEEGWLRDRLLSIELQKSSLSPLMQQIKDSTKNVLRLLLSN 162
E +R + E Q + Q E E ++ + ++ +L L + + + RL +
Sbjct: 1524 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1583
Query: 163 PQAARLLQ--MQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNS 220
+ AR +Q ++T RSAEA+ L R EK +++ + + +
Sbjct: 1584 VERARQVQVALETAQRSAEAE-----LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE 1638
Query: 221 NNQQIIDTLEKELAERMKNRNAEEELEDLDAVHREE---KISLEELRRRHKVLVGEFAQI 277
Q ++ AER + AE ELE E ++ EE+ ++ + E +
Sbjct: 1639 RRAQ-----QQAEAERAREE-AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1692
Query: 278 REEREINSKKRMEAEQEMVR 297
+EE E +++R +AE++ VR
Sbjct: 1693 KEEAEREARRRGKAEEQAVR 1712
>gi|154354990 ankyrin repeat domain 26 [Homo sapiens]
Length = 1710
Score = 49.7 bits (117), Expect = 4e-06
Identities = 63/226 (27%), Positives = 105/226 (46%), Gaps = 38/226 (16%)
Query: 101 LLENVR-CLKEKERQLQEQKEAEEEGWLRDRLLSIELQ--KSSLSPLMQQIKDSTKNVLR 157
L E +R L+ KE Q +++ E +++ L + L +EL+ KS+L+ ++Q+ D+ +
Sbjct: 808 LYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQ--- 864
Query: 158 LLLSNPQAARLLQMQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISR 217
LS Q AR+LQ Q I+ + +K + S + + +D+S
Sbjct: 865 --LSREQNARMLQDGILTNHLSKQKEIE--------MAQKKMNSENSHSHEEE--KDLSH 912
Query: 218 QNSNNQQIIDTLEKELAERMKNRNAEEE---LEDLDAV------------HREEKIS--L 260
+NS Q+ I L E+ + +KN+N E+E EDL V EE ++ +
Sbjct: 913 KNSMLQEEIAMLRLEI-DTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTI 971
Query: 261 EELRRRHKVLVGEFAQIRE--EREINSKKRMEAEQEMVRMVRAATL 304
+ R VL E A + E E SK+R+EAE E AA +
Sbjct: 972 SQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAI 1017
Score = 31.6 bits (70), Expect = 1.1
Identities = 38/211 (18%), Positives = 88/211 (41%), Gaps = 13/211 (6%)
Query: 95 EDLCQVLLENVRCLKEKERQLQEQKEAE---EEGWLRDRLLSIELQKSSLSPLMQQIKDS 151
+D +++ ++ EK+ L E++ E E L++R E +K+ +++Q++
Sbjct: 1168 QDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQE 1227
Query: 152 TKNVLRLLLSNPQAARLLQMQTQGRSAEAQNFIDSLIELRGFLFEKL--LTSPMEARDKA 209
+ L+ + + + E Q+ L ++R L E T + +K
Sbjct: 1228 LADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKM 1287
Query: 210 Q-FLQDISRQNSN-------NQQIIDTLEKELAERMKNRNAEEELEDLDAVHREEKISLE 261
Q Q + + N+ I+ L+K L + + +E+L+ L + + + +L+
Sbjct: 1288 QDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELKQSLECNLD 1347
Query: 262 ELRRRHKVLVGEFAQIREEREINSKKRMEAE 292
+ +++ L E + ++ KK E E
Sbjct: 1348 QEMKKNVELEREITGFKNLLKMTRKKLNEYE 1378
>gi|46593000 GRIP1 associated protein 1 isoform 2 [Homo sapiens]
Length = 625
Score = 49.3 bits (116), Expect = 5e-06
Identities = 64/273 (23%), Positives = 117/273 (42%), Gaps = 26/273 (9%)
Query: 25 DPSKRPADPLKPLVLSRTKLTTIEAKRIMSILDEAIYKVELVTLLSYVASNREDMEGMLG 84
DP PA P VL+ L +E K M ++ + +L L S + ++ L
Sbjct: 121 DPPGGPA----PTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELA 176
Query: 85 EDVMRAVREHEDLCQVLLENVRCLKE---KERQLQEQKEAEEEGWL-RDRLLSIELQKSS 140
+ + ++ E C++ E + K +LQ++KEA+ + L R + L EL+ ++
Sbjct: 177 KLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAAN 236
Query: 141 LSPLMQQIKDSTKNVLRLLLSNPQAARLLQMQTQGRSAEAQNFIDSLIELRGFLFEKLLT 200
S + +++D + L + A R LQ Q +SA+AQ ++ L+ L L
Sbjct: 237 QS--LAELRDQRQGER---LEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAA 291
Query: 201 SPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNRNAEEELEDLDAVHREEKISL 260
K Q L + Q + LA ++ + A E EDL + L
Sbjct: 292 LEQIQTAKTQELNMLREQTTG-----------LAAELQQQQA--EYEDLMGQKDDLNSQL 338
Query: 261 EELRRRHKVLVGEFAQIREEREINSKKRMEAEQ 293
+E R + L+ + +I +E+E +++ EA +
Sbjct: 339 QESLRANSRLLEQLQEIGQEKEQLTQELQEARK 371
Score = 37.7 bits (86), Expect = 0.015
Identities = 62/263 (23%), Positives = 106/263 (40%), Gaps = 38/263 (14%)
Query: 62 KVELVTLLSYVASNREDMEGMLGEDVMRAVREH----EDLCQVLLEN------VRCLKEK 111
K +L L + E + ML E M ++E E+L V L + VR E+
Sbjct: 359 KEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYER 418
Query: 112 E-RQLQEQKEAEEEGWLRDRLLSIELQKSSLSPLMQQIKDSTKNVLRLLLSNPQAARLLQ 170
E R+L E K+ +EE LR ++ + + L L Q +++ V + + R L+
Sbjct: 419 ELRELHEDKKRQEEE-LRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLK 477
Query: 171 MQTQGRSAEAQNFIDSLI---ELRGFLFEKLLTSPMEARDKAQ-----------FLQDIS 216
+ +G+ E Q+ D L E R + + + E +D L+D+
Sbjct: 478 -EAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLK 536
Query: 217 RQNSNNQQIIDTLEKELAERMKNRNAEEELEDLDAVHREEKISLEELRRRHKVLVGEFAQ 276
RQ ++ D L++ L + + N + LE+L L E+ + G+ +
Sbjct: 537 RQLHLERKRADKLQERLQDILTNSKSRSGLEEL---------VLSEMNSPSRTQTGDSSS 587
Query: 277 IR--EEREINSKKRMEAEQEMVR 297
I REI +K A VR
Sbjct: 588 ISSFSYREILREKESSAVPARVR 610
>gi|46592991 GRIP1 associated protein 1 isoform 1 [Homo sapiens]
Length = 841
Score = 49.3 bits (116), Expect = 5e-06
Identities = 64/273 (23%), Positives = 117/273 (42%), Gaps = 26/273 (9%)
Query: 25 DPSKRPADPLKPLVLSRTKLTTIEAKRIMSILDEAIYKVELVTLLSYVASNREDMEGMLG 84
DP PA P VL+ L +E K M ++ + +L L S + ++ L
Sbjct: 174 DPPGGPA----PTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELA 229
Query: 85 EDVMRAVREHEDLCQVLLENVRCLKE---KERQLQEQKEAEEEGWL-RDRLLSIELQKSS 140
+ + ++ E C++ E + K +LQ++KEA+ + L R + L EL+ ++
Sbjct: 230 KLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAAN 289
Query: 141 LSPLMQQIKDSTKNVLRLLLSNPQAARLLQMQTQGRSAEAQNFIDSLIELRGFLFEKLLT 200
S + +++D + L + A R LQ Q +SA+AQ ++ L+ L L
Sbjct: 290 QS--LAELRDQRQGER---LEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAA 344
Query: 201 SPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNRNAEEELEDLDAVHREEKISL 260
K Q L + Q + LA ++ + A E EDL + L
Sbjct: 345 LEQIQTAKTQELNMLREQTTG-----------LAAELQQQQA--EYEDLMGQKDDLNSQL 391
Query: 261 EELRRRHKVLVGEFAQIREEREINSKKRMEAEQ 293
+E R + L+ + +I +E+E +++ EA +
Sbjct: 392 QESLRANSRLLEQLQEIGQEKEQLTQELQEARK 424
Score = 32.7 bits (73), Expect = 0.49
Identities = 49/208 (23%), Positives = 85/208 (40%), Gaps = 43/208 (20%)
Query: 59 AIYKVELVTLLSYVASNREDMEGMLGEDVMRAVREHEDLCQVLLENV------------- 105
A Y+ EL L E++ G + E+ R RE E L Q + E
Sbjct: 467 ARYERELRELHEDKKRQEEELRGQIREEKART-RELETLQQTVEELQAQVHSMDGAKGWF 525
Query: 106 -RCLKEKERQLQEQKEAEEEGWLRDRLLSIELQKSSLSPLMQQIKDSTKNVLRLLLSNPQ 164
R LKE E LQ+Q++ +EE + R E + L ++++D +R L Q
Sbjct: 526 ERRLKEAEESLQQQQQEQEEALKQCR----EQHAAELKGKEEELQD-----VRDQLEQAQ 576
Query: 165 AARLLQMQT-QGRSAEAQNFIDS--LIELRGFLFEKLLTSPMEARDKAQFLQDISRQNSN 221
R ++T E ++ +D ++E +G + L+D+ RQ
Sbjct: 577 EERDCHLKTISSLKQEVKDTVDGQRILEKKG----------------SAALKDLKRQLHL 620
Query: 222 NQQIIDTLEKELAERMKNRNAEEELEDL 249
++ D L++ L + + N + LE+L
Sbjct: 621 ERKRADKLQERLQDILTNSKSRSGLEEL 648
Score = 32.3 bits (72), Expect = 0.64
Identities = 54/281 (19%), Positives = 119/281 (42%), Gaps = 30/281 (10%)
Query: 41 RTKLTTIEAKRIMSILDEAIYKVELVTLLSYVASNREDMEGMLGEDVMRAVREHEDLCQV 100
RT L +E + + + + + L + + + + E ++G+ +DL
Sbjct: 339 RTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQK--------DDLNSQ 390
Query: 101 LLENVRCLKEKERQLQEQKEAEEE--GWLRDRLLSIELQKSSLSPL-MQQIKDSTKNVLR 157
L E++R QLQE + +E+ L++ S E +K+ L L M+ +++ +++
Sbjct: 391 LQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEE 450
Query: 158 LLLSNPQAARLL-QMQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDIS 216
L A RL + + G A + + L E + E+L E + + + L+ +
Sbjct: 451 L-----GAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQ 505
Query: 217 RQNSNNQQIIDTLEKELAERMKNRNAEEELEDLDAVHREEKISLEELRRRHKVLV----- 271
+ Q + +++ A+ R +E E L +E++ +L++ R +H +
Sbjct: 506 QTVEELQAQVHSMDG--AKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKEE 563
Query: 272 ------GEFAQIREEREINSKKRMEAEQEMVRMVRAATLIQ 306
+ Q +EER+ + K +QE+ V +++
Sbjct: 564 ELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILE 604
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 46.6 bits (109), Expect = 3e-05
Identities = 55/224 (24%), Positives = 102/224 (45%), Gaps = 25/224 (11%)
Query: 76 REDMEGMLGEDVMRAVREHEDLCQ----VLLEN--VRCLKEKERQLQEQKEAEEEGWLRD 129
RE+ E ++ R R+ ++L Q +L E R L+E+ERQ +E++E ++E +
Sbjct: 1005 REEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQE---EE 1061
Query: 130 RLLSIELQKSSLSPLMQQIK---DSTKNVLRLLLSNPQAARLLQMQTQGRSAEAQNFIDS 186
+LL E + L +Q + + + +LL P+ R + + Q R E +
Sbjct: 1062 QLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEE- 1120
Query: 187 LIELRGFLFEKLLTSPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNRNAEEEL 246
E+LL E R + Q L+ R+ QQ + L +E E+ + + E +
Sbjct: 1121 ---------EQLLREEREKR-RRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQY 1170
Query: 247 EDLDAVHREEKISLEELRRRHKVLVGEFAQIREEREINSKKRME 290
+ + + +EE+ L E + + + Q REE E+ +KR +
Sbjct: 1171 REEEELQQEEEQLLREEQEKRR--QERERQYREEEELQRQKRKQ 1212
Score = 44.3 bits (103), Expect = 2e-04
Identities = 56/245 (22%), Positives = 111/245 (45%), Gaps = 26/245 (10%)
Query: 109 KEKERQLQEQKEAEEEGWLRDRLLSIELQKSSLSPLMQQIK---DSTKNVLRLLLSNPQA 165
+E+E++ +E++E ++E ++LL E +K +Q + + + +LL +
Sbjct: 984 QEREKKYREEEELQQE---EEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREK 1040
Query: 166 ARLLQMQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNSNNQQI 225
RL + + Q R E + E+LL E R + Q L+ R+ QQ
Sbjct: 1041 RRLQERERQYREEEELQQEE----------EQLLGEERETR-RRQELERQYRKEEELQQE 1089
Query: 226 IDTLEKELAERMKNRNAEEELEDLDAVHREEKISLEELRRRHKVLVGEFAQIREEREINS 285
+ L +E E+ + + E + + + + +EE+ L E R + + E Q REE E+
Sbjct: 1090 EEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELE-RQYREEEEVQQ 1148
Query: 286 KK----RMEAE----QEMVRMVRAATLIQALWKGYLVRSLLRSKKKRGKGKAKDKEKGKQ 337
++ R E E QE+ R R +Q + L + +++R + +++E +Q
Sbjct: 1149 EEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQ 1208
Query: 338 KGKEK 342
K K++
Sbjct: 1209 KRKQR 1213
Score = 42.4 bits (98), Expect = 6e-04
Identities = 62/295 (21%), Positives = 129/295 (43%), Gaps = 31/295 (10%)
Query: 76 REDMEGMLGEDVMRAVREHEDLCQVLLENVRCLKEKERQLQEQKEAEEEGWLRDRLLSIE 135
RE+ E +++ R RE E+L Q + +R +EK RQ +E++ EEE R +
Sbjct: 1155 REEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRY 1214
Query: 136 LQKSSLSPLMQQIKDSTKNVLR---LLLSNPQAARLLQMQ-TQGRSAEAQNFIDSLI--- 188
+ S L Q + +N +R + + + Q++ +Q R ++Q + L+
Sbjct: 1215 RDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQ 1274
Query: 189 ------ELRGFLFEKLLTSPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNRNA 242
+ R ++ P E + + + ++ R++ +Q+ L +E E+ + +
Sbjct: 1275 QERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQET 1334
Query: 243 ------------EEELEDLDAVHREEKISLEELRRR---HKVLVGEFAQIREEREINSKK 287
E E + L R+ K EELR + K L E R+ERE +K
Sbjct: 1335 DRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERE---RK 1391
Query: 288 RMEAEQEMVRMVRAATLIQALWKGYLVRSLLRSKKKRGKGKAKDKEKGKQKGKEK 342
++ EQ++ R L Q + + S+++R + +++++ +++ +E+
Sbjct: 1392 FLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERER 1446
Score = 41.2 bits (95), Expect = 0.001
Identities = 55/220 (25%), Positives = 93/220 (42%), Gaps = 18/220 (8%)
Query: 85 EDVMRAVREH---EDLCQVLLENVRCLKEKERQLQEQKEAEEEGWLRDRLLSIELQKSSL 141
+ V R RE E+ Q+ E R +E+E+ LQE++E + RDR E Q+
Sbjct: 1437 QQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQ--- 1493
Query: 142 SPLMQQIKDSTKNVLRLLLSNPQAARLLQMQTQGRSAEAQNFIDSLIELRGFLFEKLLTS 201
L +Q +D L P+ L + Q R + F+ +LR ++
Sbjct: 1494 --LRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRR---QERGQQ 1548
Query: 202 PMEARDKAQFLQDISRQNSNNQQII--DTLEKELAERMKNRNAEEE---LEDLDAVHREE 256
+ RD+ ++ RQ QQ+ + K E K R E+E +ED + R+E
Sbjct: 1549 RRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQE 1608
Query: 257 KISLEELRRRHKVLVGEFAQIREEREINSKKRMEAEQEMV 296
++LR+ E Q+ +ERE R E +++ +
Sbjct: 1609 --GQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFL 1646
Score = 41.2 bits (95), Expect = 0.001
Identities = 53/233 (22%), Positives = 94/233 (40%), Gaps = 23/233 (9%)
Query: 76 REDMEGMLGEDVMRAVREHEDLCQVLLENVRCLKEKERQLQEQKEAEEEGWLRDRLLSIE 135
R++ E ED + +R E Q+ E R +E E+ LQE++E + RDR E
Sbjct: 1590 RQEQERKFMEDEQQ-LRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEE 1648
Query: 136 LQKSSLSPLMQQIKDSTKNVLR---LLLSNPQAARLLQMQTQGRSAEAQNFIDSLIELRG 192
+ QQ++ R LL + +L + + + E + + R
Sbjct: 1649 EPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERK 1708
Query: 193 FLFEKLLTSPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNRNAEEELEDLDAV 252
FL E ++ Q++ R+ +Q+ E+E R + E E L
Sbjct: 1709 FLQE----------EQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPE 1758
Query: 253 HREEKISLEELRRRHKVLVGEFAQIREEREINSKKRMEA-----EQEMVRMVR 300
E+++ +E R+ + E Q+R+ERE + E+ E+E +R R
Sbjct: 1759 REEQQLRRQERDRKFR----EEEQLRQEREEQQLRSQESDRKFREEEQLRQER 1807
Score = 40.0 bits (92), Expect = 0.003
Identities = 52/247 (21%), Positives = 102/247 (41%), Gaps = 19/247 (7%)
Query: 110 EKERQLQEQKEAEEEGWLR-------DRLLSIELQKSSLSPLMQQIKDSTKNVLRLLLSN 162
++ RQ QE+K E L+ R E Q+ + Q + S + RL
Sbjct: 729 QRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARP 788
Query: 163 P-QAARLLQMQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISR-QNS 220
P + R Q++ + R Q F+ E E+ E + QFL++ + Q
Sbjct: 789 PLREQRERQLRAEERQQREQRFLPEEEEK-----EQRRRQRREREKELQFLEEEEQLQRR 843
Query: 221 NNQQIIDTLEKELAERMKNRNAEEELEDLDAVHREEKISLEELRRRHKVLVGEFAQIREE 280
Q + E L E + R ++E+ D ++ + LEE R+R + + ++E+
Sbjct: 844 ERAQQLQEEEDGLQEDQERRRSQEQRRD-----QKWRWQLEEERKRRRHTLYAKPALQEQ 898
Query: 281 REINSKKRMEAEQEMVRMVRAATLIQALWKGYLVRSLLRSKKKRGKGKAKDKEKGKQKGK 340
+ E E+E+ R R Q + Y L+ ++++ + ++K + +++ +
Sbjct: 899 LRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERER 958
Query: 341 EKGKGKK 347
+ K KK
Sbjct: 959 QYRKDKK 965
Score = 39.7 bits (91), Expect = 0.004
Identities = 46/211 (21%), Positives = 91/211 (43%), Gaps = 5/211 (2%)
Query: 85 EDVMRAVREHEDLCQVLLENVRCLKEKERQLQEQKEAEEEGWLRDRLLSIELQKSSLSPL 144
E + +R + L + E R +E+ R+ QE++E +EE R++ L E ++ L
Sbjct: 294 EQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEER--REQQLRREQEERREQQL 351
Query: 145 M-QQIKDSTKNVLRLLLSNPQAARLLQMQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPM 203
+Q ++ + LR + + L+ + Q R + L + E+ L
Sbjct: 352 RREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ 411
Query: 204 EARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNRNAEEELEDLDAVHREEKISLEEL 263
+ R + Q ++ + ++ + +K ER + R E+ E D + REE+ E
Sbjct: 412 QLRREQQLRREQQLRREQEEERHE--QKHEQERREQRLKREQEERRDWLKREEETERHEQ 469
Query: 264 RRRHKVLVGEFAQIREEREINSKKRMEAEQE 294
RR + L + + R ER + ++ EQ+
Sbjct: 470 ERRKQQLKRDQEEERRERWLKLEEEERREQQ 500
Score = 39.3 bits (90), Expect = 0.005
Identities = 58/238 (24%), Positives = 104/238 (43%), Gaps = 32/238 (13%)
Query: 77 EDMEGMLGEDVMRAVREHEDLCQVLLENVRCLKEK------ERQLQEQKEAEEEGWLRDR 130
E+ E ++ + RE E+L Q + +R +EK ERQ +++ E ++E ++
Sbjct: 976 EEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQE---EEQ 1032
Query: 131 LLSIELQKSSLSPLMQQIKDSTK---NVLRLLLSNPQAARLLQMQTQGRSAEAQNFIDSL 187
LL E +K L +Q ++ + +LL + R +++ Q R E +
Sbjct: 1033 LLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEE-- 1090
Query: 188 IELRGFLFEKLLTSPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNRNAEEELE 247
E+LL E R + Q + R+ QQ + L +E E+ + + E +
Sbjct: 1091 --------EQLLREEPEKR-RRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYR 1141
Query: 248 DLDAVHREEKISLE---ELRRRHKVLVGEFAQIREEREINSKKR--MEAEQEMVRMVR 300
+ + V +EE+ L E RRR ++ Q REE E+ ++ + EQE R R
Sbjct: 1142 EEEEVQQEEEQLLREEPEKRRRQEL----ERQYREEEELQQEEEQLLREEQEKRRQER 1195
Score = 38.9 bits (89), Expect = 0.007
Identities = 54/230 (23%), Positives = 105/230 (45%), Gaps = 24/230 (10%)
Query: 76 REDMEGMLGEDVMRAVREHEDLCQVLLENVRCLKEKERQLQEQKEAEEEGWLR---DRLL 132
RE+ E ++ R RE E L Q + +R +EK R+ + +++ ++ L+ ++LL
Sbjct: 915 REEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLL 974
Query: 133 SIELQKSSLSPLMQQIKDSTKNVLRLLLSNPQAARLLQMQTQGRSAEAQNFIDSLIELRG 192
E +K ++ ++ + L + L + + + R E + EL+
Sbjct: 975 GEEPEKRRRQEREKKYREEEE------LQQEEEQLLREEREKRRRQEWERQYRKKDELQQ 1028
Query: 193 FLFEKLLTSPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNRNAEEELEDLDAV 252
E+LL E R LQ+ RQ +++ E+ L E + R +E L+
Sbjct: 1029 -EEEQLLREEREKRR----LQERERQYREEEELQQEEEQLLGEERETRRRQE----LERQ 1079
Query: 253 HREEKISLEELRRRHKVLVGEFAQ--IREEREINSKKRMEAEQEMVRMVR 300
+R+E EEL++ + L+ E + R+ERE ++ E +QE +++R
Sbjct: 1080 YRKE----EELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLR 1125
Score = 38.5 bits (88), Expect = 0.009
Identities = 51/249 (20%), Positives = 108/249 (43%), Gaps = 27/249 (10%)
Query: 109 KEKERQLQ-----EQKEAEEEGWLRDRLLSIELQKSSLSPLMQQIKDSTKNVL------- 156
+ +E QLQ E +E +E LR R L +EL++ QQ ++ V
Sbjct: 187 RAEEEQLQSCKGHETEEFPDEEQLRRREL-LELRRKGREEKQQQRRERQDRVFQEEEEKE 245
Query: 157 ---RLLLSNPQAARLLQMQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQ 213
R + + +L + + Q R E Q + L +L + E +++ Q Q
Sbjct: 246 WRKRETVLRKEEEKLQEEEPQ-RQRELQEEEEQLRKLERQELRR------ERQEEEQQQQ 298
Query: 214 DISRQNSNNQQIIDTLEKELAERMKNRNAEEELEDLDAVHREEKISLEELRRRHKVLVGE 273
+ R+ QQ+ E+E E+ + R ++E + RE+++ E+ RR + L E
Sbjct: 299 RLRRE----QQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRRE 354
Query: 274 FAQIREEREINSKKRMEAEQEMVRMVRAATLIQALWKGYLVRSLLRSKKKRGKGKAKDKE 333
+ R E+++ ++ E ++ +R + Q L + +R + ++++ + +
Sbjct: 355 QEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 414
Query: 334 KGKQKGKEK 342
+ +Q +E+
Sbjct: 415 REQQLRREQ 423
Score = 37.7 bits (86), Expect = 0.015
Identities = 48/207 (23%), Positives = 91/207 (43%), Gaps = 8/207 (3%)
Query: 92 REHEDLCQVLLENVRCLKEKERQLQEQKEAE--EEGWLRDRLLSIELQKSSLSPLMQQIK 149
RE E+ + L + + +E+QL+ ++E E E+ R++ L E Q L ++ +
Sbjct: 341 REQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQ 400
Query: 150 DSTKNVLRLLLSNPQAARLLQMQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKA 209
+ LR + +L + Q R E + + R ++L E RD
Sbjct: 401 LRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERRE--QRLKREQEERRDWL 458
Query: 210 QFLQDISR--QNSNNQQIIDTLEKELAERMKNRNAEEELEDLDAVHREEKISLEELRRRH 267
+ ++ R Q QQ+ E+E ER EE E + RE+++ E+ RR
Sbjct: 459 KREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQE--RREQQLRREQEERRE 516
Query: 268 KVLVGEFAQIREEREINSKKRMEAEQE 294
+ L + + R ++ + S++++ EQE
Sbjct: 517 QRLKRQEEEERLQQRLRSEQQLRREQE 543
Score = 37.0 bits (84), Expect = 0.026
Identities = 52/235 (22%), Positives = 95/235 (40%), Gaps = 26/235 (11%)
Query: 76 REDMEGMLGEDVMRAVREHEDLCQVLLENVRCLKEKERQLQEQKEAEEEGWLRDRLLSIE 135
RE + + E+ + R+ E VL + L+E+E Q Q + + EEE +
Sbjct: 231 RERQDRVFQEEEEKEWRKRET---VLRKEEEKLQEEEPQRQRELQEEEE----------Q 277
Query: 136 LQKSSLSPLMQQIKDSTKNVLRLLLSNPQAARLLQMQTQGRSAEAQNFIDSLIELRGFLF 195
L+K L ++ ++ + RL Q R Q + + E + E +
Sbjct: 278 LRKLERQELRRERQEEEQQQQRL--RREQQLRRKQEEERREQQEERREQQERREQQEERR 335
Query: 196 EKLLTSPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNRNA----------EEE 245
E+ L E R + Q ++ + QQ+ E+E E+ R E++
Sbjct: 336 EQQLRREQEERREQQLRRE-QEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQ 394
Query: 246 LEDLDAVHREEKISLEELRRRHKVLVGEFAQIREEREINSKKRMEAEQEMVRMVR 300
L + RE+++ E+ RR + L E RE+ E +++ E E+ R+ R
Sbjct: 395 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKR 449
Score = 35.0 bits (79), Expect = 0.099
Identities = 49/250 (19%), Positives = 107/250 (42%), Gaps = 38/250 (15%)
Query: 109 KEKERQLQEQKEAEEEGWLRDRLLSIELQKSSLSPLMQQIKDSTKNVLRLLLSNPQAARL 168
+++ER+ Q K EEE L+ RL S QQ++ + LL + RL
Sbjct: 510 EQEERREQRLKRQEEEERLQQRLRS-----------EQQLRREQEERREQLLKREEEKRL 558
Query: 169 LQMQTQGR-SAEAQNFIDSLIELRGFLFEKLLTSPMEAR-----------------DKAQ 210
Q + + R E + D L++ ++ L E R + Q
Sbjct: 559 EQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQ 618
Query: 211 FLQDISRQNSNNQQIIDTLEKELAERMKNRNAEEELEDLDAVHREEKISLEE-LRRRHKV 269
L+ + QQ++ + E+E + + R ++E + EE+ LE+ L+R H+
Sbjct: 619 RLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHE- 677
Query: 270 LVGEFAQIREEREINSKKRMEAEQEM-VRMVRAATLIQALWKGYLVRSLLRSKKKRGKGK 328
+ R E+E+ +++ +A + + R+ + +++ + R +K+ G+ +
Sbjct: 678 ------EERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRR 731
Query: 329 AKDKEKGKQK 338
+++E+ +++
Sbjct: 732 RQEQEEKRRR 741
Score = 33.1 bits (74), Expect = 0.38
Identities = 46/193 (23%), Positives = 80/193 (41%), Gaps = 29/193 (15%)
Query: 110 EKERQLQEQKEAEEE--GWLRDRLLSIELQKSSLSPLMQQIKDSTKNVLRLLLSNPQAAR 167
E+ER+ Q K +EE WL+ E ++ QQ+K + R R
Sbjct: 439 EQERREQRLKREQEERRDWLKREE---ETERHEQERRKQQLKRDQEEERR--------ER 487
Query: 168 LLQMQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNSNNQQIID 227
L+++ + R + E R + E R K Q ++ +Q ++Q +
Sbjct: 488 WLKLEEEERREQQ--------ERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLR 539
Query: 228 TLEKELAERMKNRNAEEELEDLDAVHREEKISLEELRRRHKVLVGEFAQIREEREINSKK 287
++E E++ R E+ LE RE+++ E+ RR ++L E EER K
Sbjct: 540 REQEERREQLLKREEEKRLEQ---ERREQRLKREQEERRDQLLKRE-----EERRQQRLK 591
Query: 288 RMEAEQEMVRMVR 300
R + E+ R+ R
Sbjct: 592 REQEERLEQRLKR 604
Score = 30.8 bits (68), Expect = 1.9
Identities = 42/188 (22%), Positives = 81/188 (43%), Gaps = 20/188 (10%)
Query: 110 EKERQLQEQKEAEEEGWLRDRLLSIELQKSSLSPLMQQIKDSTKNVLRLLLSNPQAARLL 169
E+ER+ Q+ K +EE R+R L +E ++ ++ ++ + LR + RL
Sbjct: 468 EQERRKQQLKRDQEEE-RRERWLKLEEEER------REQQERREQQLRREQEERREQRLK 520
Query: 170 QMQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNSNNQQIIDTL 229
+ + + R + LR E+ L E R + Q L+ + ++ L
Sbjct: 521 RQEEEERLQQ---------RLRS---EQQLRREQEER-REQLLKREEEKRLEQERREQRL 567
Query: 230 EKELAERMKNRNAEEELEDLDAVHREEKISLEELRRRHKVLVGEFAQIREEREINSKKRM 289
++E ER EE + RE++ LE+ +R +V E + RE+R +
Sbjct: 568 KREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEE 627
Query: 290 EAEQEMVR 297
E Q++++
Sbjct: 628 ERRQQLLK 635
Score = 30.4 bits (67), Expect = 2.4
Identities = 26/95 (27%), Positives = 45/95 (47%), Gaps = 4/95 (4%)
Query: 196 EKLLTSPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNRNAEEELEDLDAVHRE 255
E+ L E +K + L+ RQ + + + +E ER + R EE+L+ E
Sbjct: 145 ERELAEGEEQSEKQERLEQRDRQRRDEE--LWRQRQEWQEREERRAEEEQLQSCKGHETE 202
Query: 256 EKISLEELRRRHKVLVGEFAQIREEREINSKKRME 290
E E+LRRR L+ + REE++ ++R +
Sbjct: 203 EFPDEEQLRRRE--LLELRRKGREEKQQQRRERQD 235
Score = 28.9 bits (63), Expect = 7.1
Identities = 28/134 (20%), Positives = 60/134 (44%), Gaps = 9/134 (6%)
Query: 208 KAQFLQDISRQNSNNQQIIDT----LEKELAERMKNRNAEEELEDLDAVHREEKISLEEL 263
K LQD R+ +Q+ + LE+E +R + + E+E E + + EK E
Sbjct: 106 KESLLQD--RRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQ 163
Query: 264 RRRHKVLVGEFAQIREEREINSKKRMEAEQEMVRMVRAATLIQALWKGYLVRSLLRSKKK 323
R R + + R+ +E ++ AE+E ++ + + + L R L ++
Sbjct: 164 RDRQR---RDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRR 220
Query: 324 RGKGKAKDKEKGKQ 337
+G+ + + + + +Q
Sbjct: 221 KGREEKQQQRRERQ 234
>gi|88196790 coiled-coil domain containing 88 [Homo sapiens]
Length = 1476
Score = 46.2 bits (108), Expect = 4e-05
Identities = 49/187 (26%), Positives = 87/187 (46%), Gaps = 40/187 (21%)
Query: 85 EDVMRAVREHEDLCQVLLENVRCLKEKERQLQEQKEAEEEGWLRDRLLSIELQKSSLSPL 144
E+ +R ++ D Q+LL L + +LQ E G LR RL +EL+++ L
Sbjct: 1155 EEELRRLQSEHDRAQMLLAE---LSRERGELQG-----ERGELRGRLARLELERAQLEMQ 1206
Query: 145 MQQIKDSTKNVLRLLLSNPQAARLLQMQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPME 204
QQ+++S + +L LS + ++ TQ RSA+ + E
Sbjct: 1207 SQQLRESNQ---QLDLSACRLTTQCELLTQLRSAQEE----------------------E 1241
Query: 205 ARDKAQFLQDISRQNSNNQQIIDTLEKELAER-MKNRNAEEELEDLDAVHREEKISLEEL 263
R +Q +SR+N + LE+ L R +R E L+ L+A+ RE++ +E++
Sbjct: 1242 NRQLLAEVQALSRENR------ELLERSLESRDHLHREQREYLDQLNALRREKQKLVEKI 1295
Query: 264 RRRHKVL 270
+++VL
Sbjct: 1296 MDQYRVL 1302
Score = 37.4 bits (85), Expect = 0.020
Identities = 64/269 (23%), Positives = 116/269 (43%), Gaps = 22/269 (8%)
Query: 80 EGMLGEDVMRAVREHEDLCQVLLENVRCLKEKERQLQEQKEAEEEGWLRDRLLSIELQKS 139
E L E RA++ E+L Q L + L K+R + E + RL+ +E +
Sbjct: 935 EEALMELKTRALQLEEELFQ-LRQGPAGLGPKKRAEPQLVETQNV-----RLIEVERSNA 988
Query: 140 SLSPLMQQIKDSTKNVLRLLLSNPQAARLLQMQTQGRSAEAQNFID---SLIELRGF-LF 195
L ++ +++ L S A+ L +Q+Q R+ E + + S++E++G L
Sbjct: 989 MLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQ-RAQEHSSRLQAEKSVLEIQGQELH 1047
Query: 196 EKLLTSPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNRNAEEELEDLDAVHRE 255
KL E R Q ++ Q QQ + K LA+ R E ELE L HR+
Sbjct: 1048 RKLEVLEEEVRAARQSQEETRGQ----QQALLRDHKALAQLQ--RRQEAELEGLLVRHRD 1101
Query: 256 EKISLEELRRRHKVLVGEFAQIREEREINSKKRMEAEQEMVRMVRAATLIQALWKGYLVR 315
K ++ L H+ L G Q++ +R +EA++ + R + + L
Sbjct: 1102 LKANMRALELAHRELQGRHEQLQAQR-----ASVEAQEVALLAERERLMQDGHRQRGLEE 1156
Query: 316 SLLRSKKKRGKGKAKDKEKGKQKGKEKGK 344
L R + + + + E +++G+ +G+
Sbjct: 1157 ELRRLQSEHDRAQMLLAELSRERGELQGE 1185
Score = 32.0 bits (71), Expect = 0.84
Identities = 52/233 (22%), Positives = 91/233 (39%), Gaps = 33/233 (14%)
Query: 84 GEDVMRAVREHEDLCQVLLENVRCLKEKERQLQEQKEAEEEGWLRDRLLSIELQKSSLSP 143
GE + V E E L E V L+ K L ++ EA+ +E Q + +
Sbjct: 717 GESLASGVAEQE----ALREEVAQLRRKAEALGDELEAQAR--------KLEAQNTEAAR 764
Query: 144 LMQQIKDSTKNVLRLLLSNPQAARLLQMQT--QGRSAEAQNF----IDSLIELRGFLFEK 197
L +++ + + + +A R + Q Q R EA ++S + R L E
Sbjct: 765 LSKELAQARR-------AEAEAHREAEAQAWEQARLREAVEAAGQELESASQEREALVEA 817
Query: 198 LLTSPMEARD---KAQFLQDISRQNSNNQQIIDT-----LEKELAERMKNRNAEEELEDL 249
L + E R + L+ S Q++++ LE+ ER + + ELE
Sbjct: 818 LAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEALQAELEKA 877
Query: 250 DAVHREEKISLEELRRRHKVLVGEFAQIREEREINSKKRMEAEQEMVRMVRAA 302
+E LE L+R + E + E+E ++ EQ + ++AA
Sbjct: 878 VVRGKELGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQRLEAELQAA 930
>gi|10440566 leucine zipper, putative tumor suppressor 1 [Homo
sapiens]
Length = 596
Score = 45.8 bits (107), Expect = 6e-05
Identities = 72/303 (23%), Positives = 131/303 (43%), Gaps = 61/303 (20%)
Query: 18 NRIGPKTDPSKRPADPLKPLVLSRTKLTTIEAKRI-----MSILDEAIYKVELVTLLSYV 72
+++G K P+ P+ + +E K + + L + + EL + L+Y
Sbjct: 237 SKLGHSNKADKGPSCVRSPISTDECSIQELEQKLLEREGALQKLQRSFEEKELASSLAYE 296
Query: 73 ASNR---EDMEGML---GEDVMRAVREHEDLCQVLLENVRCLKEKERQLQEQKEA--EEE 124
R +++EG G + +A ++ + QVL V L++++RQL+++ E+ +E+
Sbjct: 297 ERPRRCRDELEGPEPKGGNKLKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQ 356
Query: 125 GWLRDRLLSIELQKSSLSP------------------LMQQIKDSTKNVLRLLLSNPQAA 166
L +L S E +K+S P L QQ+K+S V N +A+
Sbjct: 357 DLLETKLRSYEREKTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEV------NAKAS 410
Query: 167 RLLQMQTQGRSAEAQNFIDSLIELRGFLFE-KLLTSPMEARDKAQFLQDISRQNSNNQQI 225
+L ++ Q + + ++ L ELR E L T +E LQ + ++
Sbjct: 411 EILGLKAQLKDTRGK--LEGL-ELRTQDLEGALRTKGLELEVCENELQRKKNEAELLREK 467
Query: 226 IDTLEKELAERMKNRNAEEEL------EDLDAVHREEKISLEELRRRHKVLVGEFAQIRE 279
++ LE+EL E ++ ED+ A+ RE LE LR A++RE
Sbjct: 468 VNLLEQELQELRAQAALARDMGPPTFPEDVPALQRE----LERLR----------AELRE 513
Query: 280 ERE 282
ER+
Sbjct: 514 ERQ 516
>gi|68299759 ecotropic viral integration site 5 [Homo sapiens]
Length = 810
Score = 45.4 bits (106), Expect = 7e-05
Identities = 53/233 (22%), Positives = 109/233 (46%), Gaps = 14/233 (6%)
Query: 109 KEKERQLQEQKEAEEEGWLRDRLLSIELQKSSLSPLMQQIKDSTKNVLRLLLSNPQA-AR 167
KE E Q++ ++ E L+ R+ ++E K S + + K +++ LS ++
Sbjct: 421 KEMEEQVEIKRLRTENRLLKQRIETLEKHKCSSNYNEDFVLQLEKELVQARLSEAESQCA 480
Query: 168 LLQMQTQGRSAEAQNFIDSLIELRGF--LFEKLLTSPMEARDKAQFLQDISRQNSNNQQI 225
L +MQ + E +N +SL + L E+L+ + + L+++ +Q + ++
Sbjct: 481 LKEMQDKVLDIEKRN--NSLPDENNIARLQEELIAVKLREAEAIMGLKELRQQVKDLEEH 538
Query: 226 IDTLEKELAERMKN---RNAEEELED-LDAVHREEKISLEELRRRHKVLVGEFAQIREER 281
R K+ +NA EL+D L + E + E+R + ++ ++ +
Sbjct: 539 WQRHLARTTGRWKDPPKKNAMNELQDELMTIRLREAETQAEIREIKQRMM----EMETQN 594
Query: 282 EINSKKRMEAEQEMVRMVRAATLIQALWKGYLVRSLLRSKKKRGKGKAKDKEK 334
+INS AEQE++ + + A KG L+ L +K+K+ + + K+KE+
Sbjct: 595 QINSNHLRRAEQEVISLQEKVQYLSAQNKG-LLTQLSEAKRKQAEIECKNKEE 646
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 45.4 bits (106), Expect = 7e-05
Identities = 69/336 (20%), Positives = 139/336 (41%), Gaps = 24/336 (7%)
Query: 18 NRIGPKTDPSKRPADPLKPLVLSRTKLTTIEAKRIMSILDEAIYKVELVTLLSYVASNRE 77
N + D +R D K L +TK +A+ S+ + EL L + +
Sbjct: 1437 NSLAAALDKKQRNFD--KVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALD 1494
Query: 78 DMEGMLGEDVMRAVREHEDLCQVLLENVRCLKE--KERQLQEQKEAEEEGWLRDRLLSIE 135
+E + E+ +E DL + + EN + + E K R+ E ++A+ + L + ++E
Sbjct: 1495 QLETVKREN-KNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALE 1553
Query: 136 LQKSSLSPLMQQIKDSTKNVLRLLLSNPQAARLLQMQTQGRSAEAQNFIDSLIELRGFLF 195
+++ + + ++ + R + + L+ Q Q+ +D+ + R
Sbjct: 1554 HEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAI 1613
Query: 196 EKLLTSPMEARDKAQFLQDISRQNSN-NQQIIDTLEKELAERMKNRNAEEELEDLDAVHR 254
L ME L +I Q S+ N+Q +TL+ + + + ++ + L+D
Sbjct: 1614 R--LKKKMEGD-----LNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQE 1666
Query: 255 EEKISLEELRRRHKVLVGEFAQIREEREINSKKRMEAEQEMVRMVRAATLIQALWKGYLV 314
+ K L + RR +L E ++R E + R AEQE++ L+
Sbjct: 1667 DLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHT-----QN 1721
Query: 315 RSLLRSKKK------RGKGKAKDKEKGKQKGKEKGK 344
SL+ +KKK + + + +D + + +EK K
Sbjct: 1722 TSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAK 1757
Score = 42.4 bits (98), Expect = 6e-04
Identities = 59/271 (21%), Positives = 111/271 (40%), Gaps = 28/271 (10%)
Query: 40 SRTKLTTIEAKRIMSILDEAIYKVELVTLLSYVASNREDMEGM-LGEDVMRAVREHEDLC 98
++T+ + R + L E + + VT + + + E + L D+ A +HE +
Sbjct: 1131 AKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMV 1190
Query: 99 QVL----LENVRCLKEKERQLQEQKEAEEEGWLRDRLLSIELQKSSLSPLMQQIKDSTKN 154
L ++V L E+ LQ K+ E+ +L+ LS M+ + S N
Sbjct: 1191 AALRKKHADSVAELGEQIDNLQRVKQKLEK-----EKSEFKLEIDDLSSSMESVSKSKAN 1245
Query: 155 VLRLLLSNPQAARLLQMQ---TQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQF 211
+ ++ R L+ Q +G++ E Q + L + L + + +K
Sbjct: 1246 LEKI-------CRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESI 1298
Query: 212 LQDISRQNSNNQQIIDTLEKELAERMKNRNA-----EEELEDLDAV---HREEKISLEEL 263
+ +SR Q + L+++L E K +NA + D D + + EE+ EL
Sbjct: 1299 VSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAEL 1358
Query: 264 RRRHKVLVGEFAQIREEREINSKKRMEAEQE 294
+R E AQ R + E ++ +R E +E
Sbjct: 1359 QRALSKANSEVAQWRTKYETDAIQRTEELEE 1389
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 45.4 bits (106), Expect = 7e-05
Identities = 60/283 (21%), Positives = 121/283 (42%), Gaps = 50/283 (17%)
Query: 59 AIYKVELVTLLSYVASNREDME-------GMLGEDVMRAVREHEDLCQVLLENVRCLKE- 110
A+++ +L+TL R++++ G+ ++ R+ +L ++ R L++
Sbjct: 829 AMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQV 888
Query: 111 KERQLQEQKEAEEEGWLRDRLLSIELQKSSLSPLMQQIKDSTKNVLRLLLSNPQAARLLQ 170
+E++++ QK A++ L++++ + + + L L+++ + + R L+ P A Q
Sbjct: 889 QEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQ 948
Query: 171 MQ----TQGRS------------AEAQNFIDSLIELRGFLFEKLLTSPMEA----RDKAQ 210
+ QGR EA+ + L LR L E E R+ A+
Sbjct: 949 PEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVAR 1008
Query: 211 FLQDISR-------------------QNSNNQQIID--TLEKELAERMKNRNA-EEELED 248
Q+ R QN+ N+Q ++ TL++ LA + + ++EL
Sbjct: 1009 LTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAK 1068
Query: 249 LDAVHREEKISLEELRRRHKVLVGEFAQIREEREINSKKRMEA 291
L + + LEELR+ K L + A+ +E S + EA
Sbjct: 1069 LRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEA 1111
Score = 35.0 bits (79), Expect = 0.099
Identities = 68/302 (22%), Positives = 126/302 (41%), Gaps = 21/302 (6%)
Query: 50 KRIMSILDEAIYKVELVTLLSYVASNREDMEGMLGEDVMRAVREHEDLCQVLLENVRCLK 109
K++ ++ E K+E++ VA+ D V +A RE +L + + E C+
Sbjct: 604 KQLEALEKEKAAKLEILQQQLQVANEARDSAQT---SVTQAQREKAELSRKVEELQACV- 659
Query: 110 EKERQLQEQKEAEEEGWLRDRLLSIELQKSSLSPLMQQIKDSTKNVLRLLLSNPQAARLL 169
E QEQ EA+ + + L E QK++ + Q KD + L+ L + + +
Sbjct: 660 --ETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGS 717
Query: 170 QMQTQGRSAEA----QNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQ----NSN 221
+ + R+A+A Q I L L E+ E ++ + + +
Sbjct: 718 LEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEA 777
Query: 222 NQQIIDTLEKELAERM-KNRNAEEELEDL---DAVHREE-KISLEELRRRHKVLVGEFAQ 276
+Q + L +ELAE M AE E E L A RE + S +E + + +
Sbjct: 778 HQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMT 837
Query: 277 IREEREINSKKRMEAEQEMVRMVRAATLIQALWKGYLVRSLLRSKKKRGKGKAKDKEKGK 336
++EE E ++ EA++++ + + L + + L L + R + ++KE
Sbjct: 838 LKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAE--LHANLARALQQVQEKEVRA 895
Query: 337 QK 338
QK
Sbjct: 896 QK 897
Score = 34.7 bits (78), Expect = 0.13
Identities = 60/293 (20%), Positives = 118/293 (40%), Gaps = 45/293 (15%)
Query: 64 ELVTLLSYVASNREDMEGMLGE------DVMRAVREHEDLCQVLLENVR----CLKEKER 113
EL TL + + +++ G+ + + + +++ E Q L V LK+KE+
Sbjct: 506 ELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQ 565
Query: 114 QLQEQKEAEEEGWLRDRLLSIELQKSSLSPLMQQIKDSTKNVLRLLLSNPQAARLLQMQT 173
QL+E E ++E +D + +++ + K + L +LQ Q
Sbjct: 566 QLKEVAE-KQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQL 624
Query: 174 QGRSA---EAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNSNNQQI-IDTL 229
Q + AQ + + L K+ ++ Q + +RQ + Q + L
Sbjct: 625 QVANEARDSAQTSVTQAQREKAELSRKV--------EELQACVETARQEQHEAQAQVAEL 676
Query: 230 EKEL-AERMKNRNAEEELEDLDAVHREEKISLEELRRRHKVLVGEFAQIREEREINSKKR 288
E +L +E+ K E ++ D + + L+ L+ KV G EE + +
Sbjct: 677 ELQLRSEQQKATEKERVAQEKDQLQEQ----LQALKESLKVTKGSL----EEEKRRAADA 728
Query: 289 MEAEQEMVRMVRAATLIQALWKGYLVRSLLRSKKKRGKGKAKDKEKGKQKGKE 341
+E +Q + ++A T RSL+ K+ + K ++E+ +KG E
Sbjct: 729 LEEQQRCISELKAET-----------RSLVEQHKR--ERKELEEERAGRKGLE 768
Score = 33.5 bits (75), Expect = 0.29
Identities = 52/242 (21%), Positives = 101/242 (41%), Gaps = 44/242 (18%)
Query: 81 GMLGEDVMRAVREHEDLCQVLLENVRCLKEKERQLQEQKEAEEEGWLRDRLLSIELQKSS 140
G+L E+ R + E +L + LE V + +E+ +QE L ++ +
Sbjct: 1445 GLLAEE-NRGLGERANLGRQFLE-VELDQAREKYVQE-------------LAAVRADAET 1489
Query: 141 LSPLMQQIKDSTKNVLRLLLSNPQAARLLQMQTQGRSAEAQNFIDSLIE-LRGF------ 193
+Q+ ST L ++ + + A++ ++ + R E + + + +E L F
Sbjct: 1490 RLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTK 1549
Query: 194 ----LFEKLLTSPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNRNAEEELED- 248
L +KL S ++ + Q L+ + Q +QQ L+ +L E + +E+ +
Sbjct: 1550 QVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEH 1609
Query: 249 -----------LDAVHR------EEKISLEELRRRHKVLVGEFAQIREEREINSKKRMEA 291
DA + E+ SLE+L++ +K L E ++ E + K EA
Sbjct: 1610 YKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEA 1669
Query: 292 EQ 293
EQ
Sbjct: 1670 EQ 1671
>gi|110611218 ribosome binding protein 1 [Homo sapiens]
Length = 977
Score = 45.1 bits (105), Expect = 1e-04
Identities = 82/342 (23%), Positives = 149/342 (43%), Gaps = 74/342 (21%)
Query: 9 APLYQAPAINRIGPKTDPSKRPADPLKPLVLS-RTKLTTI--------EAKRIMSILDEA 59
AP +APA + G K K P D PL L +T ++T+ EA+R++ IL E
Sbjct: 188 APKQEAPAKKKSGSK---KKGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILSE- 243
Query: 60 IYKVELVTLLSYVASNREDMEGMLGEDVMRAVREHEDLCQVLLENVRCLKEKERQLQEQK 119
K ++ + A+ + D +L R + E E L E+ K K R+L ++
Sbjct: 244 --KAGIIQDTWHKATQKGDPVAIL----KRQLEEKEKLLATEQEDAAVAKSKLRELNKEM 297
Query: 120 EAEE------EGWLRDRLLSIELQKSSLSPLMQ-----------QIKDSTKNVLRLLLSN 162
AE+ E ++ +L++ E + +++ MQ Q++ + + L +
Sbjct: 298 AAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENG 357
Query: 163 P--QAARLLQMQTQGRSA--EAQNFIDS-----LIELRGFLFE--KLLTSPMEA--RDKA 209
P Q ARL Q + R A +A + ++S L +LR L + K L EA +D+
Sbjct: 358 PNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQ 417
Query: 210 Q----------FLQDISRQNSNNQQIIDTLEKELAE---------------RMKNRNAEE 244
Q F + + + +++++ + L+K L E R A+E
Sbjct: 418 QRKALEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQE 477
Query: 245 ELEDLDAVHREEKISLEELRRRHKVLVGEFAQIREEREINSK 286
+ + + +H + + S E+R + + L G Q++E R NS+
Sbjct: 478 QQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQ 519
>gi|110611220 ribosome binding protein 1 [Homo sapiens]
Length = 977
Score = 45.1 bits (105), Expect = 1e-04
Identities = 82/342 (23%), Positives = 149/342 (43%), Gaps = 74/342 (21%)
Query: 9 APLYQAPAINRIGPKTDPSKRPADPLKPLVLS-RTKLTTI--------EAKRIMSILDEA 59
AP +APA + G K K P D PL L +T ++T+ EA+R++ IL E
Sbjct: 188 APKQEAPAKKKSGSK---KKGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILSE- 243
Query: 60 IYKVELVTLLSYVASNREDMEGMLGEDVMRAVREHEDLCQVLLENVRCLKEKERQLQEQK 119
K ++ + A+ + D +L R + E E L E+ K K R+L ++
Sbjct: 244 --KAGIIQDTWHKATQKGDPVAIL----KRQLEEKEKLLATEQEDAAVAKSKLRELNKEM 297
Query: 120 EAEE------EGWLRDRLLSIELQKSSLSPLMQ-----------QIKDSTKNVLRLLLSN 162
AE+ E ++ +L++ E + +++ MQ Q++ + + L +
Sbjct: 298 AAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENG 357
Query: 163 P--QAARLLQMQTQGRSA--EAQNFIDS-----LIELRGFLFE--KLLTSPMEA--RDKA 209
P Q ARL Q + R A +A + ++S L +LR L + K L EA +D+
Sbjct: 358 PNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQ 417
Query: 210 Q----------FLQDISRQNSNNQQIIDTLEKELAE---------------RMKNRNAEE 244
Q F + + + +++++ + L+K L E R A+E
Sbjct: 418 QRKALEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQE 477
Query: 245 ELEDLDAVHREEKISLEELRRRHKVLVGEFAQIREEREINSK 286
+ + + +H + + S E+R + + L G Q++E R NS+
Sbjct: 478 QQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQ 519
>gi|116256481 TNFAIP3 interacting protein 1 [Homo sapiens]
Length = 636
Score = 44.7 bits (104), Expect = 1e-04
Identities = 53/238 (22%), Positives = 102/238 (42%), Gaps = 25/238 (10%)
Query: 110 EKERQLQEQKEAE----EEGWLRDRLLSIELQKSSLSPLMQQIKDSTKNVLRLLLSNPQA 165
EK+ ++ EQ+ +E + W + + + ++ L Q++ D K V L Q
Sbjct: 300 EKKVKMLEQQRSELLEVNKQWDQHFRSMKQQYEQKITELRQKLADLQKQVTDLEAEREQK 359
Query: 166 ARLLQMQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQD----ISRQNSN 221
R + S IE+ E+L E R K ++LQD ++RQ
Sbjct: 360 QRDFDRKLL--------LAKSKIEMEETDKEQLTAEAKELRQKVKYLQDQLSPLTRQREY 411
Query: 222 NQQIIDTLEKELAERMKNR-------NAEEELEDLDAVHREEKI--SLEELRRRHKVLVG 272
++ I L K L E + + A E A+ R++++ E L+++ K+
Sbjct: 412 QEKEIQRLNKALEEALSIQTPPSSPPTAFGSPEGAGALLRKQELVTQNELLKQQVKIFEE 471
Query: 273 EFAQIREEREINSKKRMEAEQEMVRMVRAATLIQALWKGYLVRSLLRSKKKRGKGKAK 330
+F + R +RE ++++ E ++++ ++ TL A K + R ++ K KAK
Sbjct: 472 DFQRERSDRERMNEEKEELKKQVEKLQAQVTLSNAQLKAFKDEEKAREALRQQKRKAK 529
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 44.7 bits (104), Expect = 1e-04
Identities = 51/248 (20%), Positives = 120/248 (48%), Gaps = 11/248 (4%)
Query: 25 DPSKRPADPLKPLVLSRTKLTTIEAKRIMSILDEAIYKVELVTLLSYVASNREDMEGMLG 84
+ S+R A LS + T +++ + +DE I +E + + S ++++ +
Sbjct: 406 EKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERI-SLQQELSRVKQ 464
Query: 85 E--DVMRAVREHEDLCQVLLENVRCLKEKERQLQEQKEAEEEGWLRDRLLSIELQKSSLS 142
E DVM+ E E + ++ + + L KE++L ++ + E + +++E +S
Sbjct: 465 EVVDVMKKSSE-EQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYL 523
Query: 143 PLMQQIKDSTKNVLRLLLSNPQAARLLQMQTQGRSA--EAQNFIDSLIELRGFLFEKLLT 200
+ Q+ K+ +++ L + A L + + + R EA+ + ++EL L + L
Sbjct: 524 KISQE-KEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQE 582
Query: 201 SPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNRNAEEEL--EDLDAVHREEKI 258
+ +++D A L+ + +N +N++I +EK E ++ ++ L E L + ++ +
Sbjct: 583 NKNQSKDLAVHLE--AEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQT 640
Query: 259 SLEELRRR 266
+E+LR +
Sbjct: 641 EMEKLREK 648
Score = 43.9 bits (102), Expect = 2e-04
Identities = 51/227 (22%), Positives = 110/227 (48%), Gaps = 18/227 (7%)
Query: 85 EDVMRAVREHEDLCQVLLENVRCLKEKERQLQEQKEAEEEGWLRDRLLSIE----LQKSS 140
E + + V+ E+L + E ++ KE+ L +KEA +E L +RL +E L +
Sbjct: 282 ETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQ-LDERLQELEKIKDLHMAE 340
Query: 141 LSPLMQQIKDSTKNVLRLLLSNPQAARLLQMQTQGRSAEAQNFIDSLIELRGFLFEKLLT 200
+ L+ Q++D+ KN++ L Q ++ +T+ + E + I +++ T
Sbjct: 341 KTKLITQLRDA-KNLIEQL---EQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTT 396
Query: 201 SPMEARDKAQFLQDISRQNSNNQQIIDTLEK-ELAERMKNRNAEEELEDLDAVHREEKIS 259
E R++ + + + + ++ + T +K E A R +E+++ ++ EE+IS
Sbjct: 397 QGEELREQKEKSERAAFEEL--EKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERIS 454
Query: 260 L-EELRRRHKVLVGEFAQIREE-----REINSKKRMEAEQEMVRMVR 300
L +EL R + +V + EE ++++ K+ EQE+ + ++
Sbjct: 455 LQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQ 501
Score = 43.1 bits (100), Expect = 4e-04
Identities = 63/282 (22%), Positives = 128/282 (45%), Gaps = 28/282 (9%)
Query: 64 ELVTLLSYVASNREDMEGMLGEDVMRAVREHEDLCQVLLENVRCLKEKERQLQEQKEAEE 123
ELVT + ++ ++G+L + +++R + L E ++ ++ ++ LQE+ +A
Sbjct: 159 ELVTAYQMLQREKKKLQGILSQSQDKSLRRIAE----LREELQMDQQAKKHLQEEFDASL 214
Query: 124 EGWLRDRLLSIELQKSSLSPLMQQIKDSTKNVLRLLLSNPQAARLLQMQTQGRSAEAQNF 183
E +D+ +S+ ++ +S L Q++++ NV +L PQ ++ T+ + E+
Sbjct: 215 EE--KDQYISV--LQTQVSLLKQRLRNGPMNV-DVLKPLPQLEPQAEVFTKEENPESDG- 268
Query: 184 IDSLIELRGFLFEKLLTSPMEARDKAQFLQDISR--QNSNNQQIIDTLEKE-LAERMKNR 240
+ ++E G + L T + + L+ Q+ Q + T EKE L E++ R
Sbjct: 269 -EPVVE-DGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDER 326
Query: 241 NAEEELEDLDAVHREEKISLEELRRRHKVLVGEFAQIREEREINSKKRMEAEQEMVRMVR 300
+ELE + +H EK L R K L+ + Q + +K++M EM
Sbjct: 327 --LQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEI 384
Query: 301 AATLIQALWKGYLVRSLLRSKKKRGKGKAKDKEKGKQKGKEK 342
A +RS ++ +G+ + KEK ++ E+
Sbjct: 385 AQ-----------LRSRIKQMTTQGEELREQKEKSERAAFEE 415
Score = 42.0 bits (97), Expect = 8e-04
Identities = 49/228 (21%), Positives = 101/228 (44%), Gaps = 37/228 (16%)
Query: 76 REDMEGMLGEDVMRAVREHEDLCQVLLENVR----CL-KEKERQLQEQKEAEEEGWLRDR 130
++++E + +DV + ++E E CQ+L + ++ CL ++KE E +E +
Sbjct: 1828 KQNLENVF-DDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQA 1886
Query: 131 LLSIELQKSSLSPLMQQIKDSTKN--VLRLLLSNPQAARL-LQMQTQGRSAEAQNFIDSL 187
L ++ + L + ++ +K+ V LLSN +A L+ + G E Q +
Sbjct: 1887 LQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEI 1946
Query: 188 IELRGFLFEKLLTSPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNRNAEEELE 247
+ L+ +D+ +QQ ++ L+KE ++ + ++E E
Sbjct: 1947 VRLQ---------------------KDLRMLRKEHQQELEILKKEY-DQEREEKIKQEQE 1984
Query: 248 DLDAVHREEKISLEELRRRHKVLVGEFAQIREEREINSKKRMEAEQEM 295
DL+ H +L++L R + AQ +E E+ K+ + QE+
Sbjct: 1985 DLELKHNS---TLKQLMREFNT---QLAQKEQELEMTIKETINKAQEV 2026
Score = 35.4 bits (80), Expect = 0.076
Identities = 46/227 (20%), Positives = 101/227 (44%), Gaps = 28/227 (12%)
Query: 69 LSYVASNREDMEGMLGEDVMRAVREHEDLCQVLLENVRCLKEKERQLQEQKEAEEEGWLR 128
L + + E + LG++++R ++ L + + + LK++ Q +E+K +E+
Sbjct: 1928 LEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQE--- 1984
Query: 129 DRLLSIELQ-KSSLSPLMQQIKDSTKNVLRLLLSNPQAARLLQMQTQGRSAEAQNFIDSL 187
+EL+ S+L LM++ Q + L+M + +AQ L
Sbjct: 1985 ----DLELKHNSTLKQLMREFNTQL----------AQKEQELEMTIKETINKAQEVEAEL 2030
Query: 188 IELRGFLFEKLLTSPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNRNAEEELE 247
+E +LL E D D+ R ++I+D E+E+ ++ R+ + +LE
Sbjct: 2031 LESHQEETNQLLKKIAEKDD------DLKRTAKRYEEILDAREEEMTAKV--RDLQTQLE 2082
Query: 248 DLDAVHREEKISLEELRRRHKVLVGEF-AQIREEREINSKKRMEAEQ 293
+L + ++K+ EE V + E Q+ ++ + S +++ ++
Sbjct: 2083 ELQKKY-QQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQE 2128
Score = 34.3 bits (77), Expect = 0.17
Identities = 70/341 (20%), Positives = 146/341 (42%), Gaps = 55/341 (16%)
Query: 34 LKPLVLSRTKLTTIEAKRIMSILDEAIYKVE--LVTLLSYVASNREDMEGMLGED----- 86
L+ L + +T+L ++ ++ +S + +A +K+E L L ++++E + E
Sbjct: 676 LEKLDVKQTELESLSSE--LSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQ 733
Query: 87 --VMRAVREHEDLCQ----VLLENVR----CLKEKERQLQEQKEAEE---------EGWL 127
V ++EHE Q L + + LKE+++ L+E + E EG L
Sbjct: 734 QQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGEL 793
Query: 128 RDRLLSIELQKSSLSPLMQQIKDSTKNVLRLL--LSNPQAARLLQMQTQGRSAEAQNFID 185
+ +++ +S S +Q K + + +L L + + R+L + Q EAQ
Sbjct: 794 QQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERIL-LTKQVAEVEAQ---- 848
Query: 186 SLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNRNAEEE 245
+ + +L ++ +D +Q + +QNS +Q + +L + ++++ N E+E
Sbjct: 849 -----KKDVCTELDAHKIQVQD---LMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQE 900
Query: 246 LEDLDAVHRE---------EKISLEELRRRHKVLVGEFAQIREEREINSKKRMEAEQEMV 296
V +E +K +E L ++ + EE E K + E++M
Sbjct: 901 QTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQ---EKKME 957
Query: 297 RMVRAATLIQALWKGYLVRSLLRSKKKRGKGKAKDKEKGKQ 337
++ + A +Q K L+ + KK+ + +K KQ
Sbjct: 958 KVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQ 998
Score = 32.0 bits (71), Expect = 0.84
Identities = 34/163 (20%), Positives = 72/163 (44%), Gaps = 12/163 (7%)
Query: 114 QLQEQKEAEEEGWLRDRLLSIELQKSSLSPLMQQIKDSTKNVLRLLLSNPQAARLLQMQT 173
++Q Q++ +E L+ ++L +K ++ + +K+ + LQ Q
Sbjct: 1063 EIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEG-------VKQDTTLNELQEQL 1115
Query: 174 QGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNSNNQQIIDTLEKEL 233
+ +SA + +L+ L EKL ++ + FLQ+ Q + + + ++++
Sbjct: 1116 KQKSAHVNSLAQDETKLKAHL-EKLEVDLNKSLKENTFLQE---QLVELKMLAEEDKRKV 1171
Query: 234 AE-RMKNRNAEEELEDLDAVHREEKISLEELRRRHKVLVGEFA 275
+E K + +EE + L + H + SLE+ K L E A
Sbjct: 1172 SELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELA 1214
Score = 32.0 bits (71), Expect = 0.84
Identities = 19/96 (19%), Positives = 47/96 (48%), Gaps = 1/96 (1%)
Query: 204 EARDKAQFLQDISRQNSNNQQIIDTLEKELAERMK-NRNAEEELEDLDAVHREEKISLEE 262
+ + K+ + +++ + + ++ LE +L + +K N +E+L +L + E+K + E
Sbjct: 1114 QLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSE 1173
Query: 263 LRRRHKVLVGEFAQIREEREINSKKRMEAEQEMVRM 298
L + K EF ++ E ++K + E ++
Sbjct: 1174 LTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKL 1209
>gi|33356174 pinin, desmosome associated protein [Homo sapiens]
Length = 717
Score = 44.7 bits (104), Expect = 1e-04
Identities = 44/201 (21%), Positives = 87/201 (43%), Gaps = 11/201 (5%)
Query: 105 VRCLKEKERQLQEQKEAEEEGWLRDRLLSIELQKSSLSPLMQQIKDSTKNVLRLLLSNPQ 164
V+ +E+++ E++E EE + L + QK L+ L ++ + +++ + + +
Sbjct: 179 VQAEEERKQVENERRELFEERRAKQTELRLLEQKVELAQLQEEWNEHNAKIIKYIRTKTK 238
Query: 165 AARL-----LQMQTQGRSAEAQNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQN 219
+ TQ E+Q +++L E R F + + MEAR + Q +++ Q
Sbjct: 239 PHLFYIPGRMCPATQKLIEESQRKMNALFEGRRIEFAEQINK-MEARPRRQSMKEKEHQV 297
Query: 220 SNNQQIIDTLEKELAERMKNRNAEEELEDLDAVHREEKISLEELRRRHKVLVGEFAQIRE 279
N++ +K E K EEELE+ H + +I ++ + +E
Sbjct: 298 VRNEE-----QKAEQEEGKVAQREEELEETGNQHNDVEIEEAGEEEEKEIAIVHSDAEKE 352
Query: 280 EREINSKKRMEAEQEMVRMVR 300
+ E K+ ME + E VR
Sbjct: 353 QEEEEQKQEMEVKMEEETEVR 373
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.130 0.345
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,491,809
Number of Sequences: 37866
Number of extensions: 509767
Number of successful extensions: 6274
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 144
Number of HSP's successfully gapped in prelim test: 619
Number of HSP's that attempted gapping in prelim test: 4002
Number of HSP's gapped (non-prelim): 2248
length of query: 347
length of database: 18,247,518
effective HSP length: 103
effective length of query: 244
effective length of database: 14,347,320
effective search space: 3500746080
effective search space used: 3500746080
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.