Search of human proteins with 19923817

Search of human proteins with 19923817

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo
sapiens]
         (303 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens]    608   e-174
gi|4503301 2,4-dienoyl CoA reductase 1 precursor [Homo sapiens]       157   1e-38
gi|10190704 2,4-dienoyl CoA reductase 2 [Homo sapiens]                152   3e-37
gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo ...   115   5e-26
gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo sapi...   110   1e-24
gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo...   109   3e-24
gi|40254992 carbonic reductase 4 [Homo sapiens]                       107   1e-23
gi|126723750 dehydrogenase/reductase (SDR family) member 4 like ...    95   9e-20
gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo sap...    89   5e-18
gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]           88   8e-18
gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens]     80   2e-15
gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform ...    78   8e-15
gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]        74   2e-13
gi|126723191 dehydrogenase/reductase (SDR family) member 4 like ...    74   2e-13
gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Hom...    73   3e-13
gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens]     72   6e-13
gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo s...    68   9e-12
gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform...    68   1e-11
gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens]              67   2e-11
gi|40254986 hydroxysteroid dehydrogenase like 2 [Homo sapiens]         66   4e-11
gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo sa...    65   7e-11
gi|209862901 dehydrogenase/reductase (SDR family) member 1 [Homo...    64   1e-10
gi|19923983 dehydrogenase/reductase (SDR family) member 1 [Homo ...    64   1e-10
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo...    64   2e-10
gi|4557649 estradiol 17 beta-dehydrogenase 3 [Homo sapiens]            62   6e-10
gi|4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1 [...    60   3e-09
gi|186928839 retinol dehydrogenase 12 [Homo sapiens]                   56   4e-08
gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A...    55   6e-08
gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo ...    54   2e-07
gi|226371731 hydroxysteroid dehydrogenase like 1 isoform a [Homo...    54   2e-07

>gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens]
          Length = 303

 Score =  608 bits (1569), Expect = e-174
 Identities = 303/303 (100%), Positives = 303/303 (100%)

Query: 1   MASWAKGRSYLAPGLLQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAAD 60
           MASWAKGRSYLAPGLLQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAAD
Sbjct: 1   MASWAKGRSYLAPGLLQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAAD 60

Query: 61  ELQANLPPTKQARVIPIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHIS 120
           ELQANLPPTKQARVIPIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHIS
Sbjct: 61  ELQANLPPTKQARVIPIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHIS 120

Query: 121 SKGWHAVLETNLTGTFYMCKAVYSSWMKEHGGSIVNIIVPTKAGFPLAVHSGAARAGVYN 180
           SKGWHAVLETNLTGTFYMCKAVYSSWMKEHGGSIVNIIVPTKAGFPLAVHSGAARAGVYN
Sbjct: 121 SKGWHAVLETNLTGTFYMCKAVYSSWMKEHGGSIVNIIVPTKAGFPLAVHSGAARAGVYN 180

Query: 181 LTKSLALEWACSGIRINCVAPGVIYSQTAVENYGSWGQSFFEGSFQKIPAKRIGVPEEVS 240
           LTKSLALEWACSGIRINCVAPGVIYSQTAVENYGSWGQSFFEGSFQKIPAKRIGVPEEVS
Sbjct: 181 LTKSLALEWACSGIRINCVAPGVIYSQTAVENYGSWGQSFFEGSFQKIPAKRIGVPEEVS 240

Query: 241 SVVCFLLSPAASFITGQSVDVDGGRSLYTHSYEVPDHDNWPKGAGDLSVVKKMKETFKEK 300
           SVVCFLLSPAASFITGQSVDVDGGRSLYTHSYEVPDHDNWPKGAGDLSVVKKMKETFKEK
Sbjct: 241 SVVCFLLSPAASFITGQSVDVDGGRSLYTHSYEVPDHDNWPKGAGDLSVVKKMKETFKEK 300

Query: 301 AKL 303
           AKL
Sbjct: 301 AKL 303


>gi|4503301 2,4-dienoyl CoA reductase 1 precursor [Homo sapiens]
          Length = 335

 Score =  157 bits (397), Expect = 1e-38
 Identities = 92/264 (34%), Positives = 142/264 (53%), Gaps = 11/264 (4%)

Query: 8   RSYLAPGLLQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLP 67
           ++ L P   QG+VA +TGG TG+GK +   L  LG+  VIASRK++ LK+ A+++ +   
Sbjct: 49  KAMLPPNSFQGKVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQ-- 106

Query: 68  PTKQARVIPIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHISSKGWHAV 127
                +V  IQC++R+ + V N V   +   G  N ++NN  G F+SP E +S   W  +
Sbjct: 107 --TGNKVHAIQCDVRDPDMVQNTVSELIKVAGHPNIVINNAAGNFISPTERLSPNAWKTI 164

Query: 128 LETNLTGTFYMCKAVYSSWMKEHGG----SIVNIIVPTKAGFPLAVHSGAARAGVYNLTK 183
            +  L GT ++   +    +K   G    SI  I   T +GF   V S +A+AGV  ++K
Sbjct: 165 TDIVLNGTAFVTLEIGKQLIKAQKGAAFLSITTIYAETGSGF--VVPSASAKAGVEAMSK 222

Query: 184 SLALEWACSGIRINCVAPGVIYSQTAVENYGSWGQSFFEGSFQKIPAKRIGVPEEVSSVV 243
           SLA EW   G+R N + PG I ++ A       G +F +    +IP  R+G  EE++++ 
Sbjct: 223 SLAAEWGKYGMRFNVIQPGPIKTKGAFSRLDPTG-TFEKEMIGRIPCGRLGTVEELANLA 281

Query: 244 CFLLSPAASFITGQSVDVDGGRSL 267
            FL S  AS+I G  +  DGG  +
Sbjct: 282 AFLCSDYASWINGAVIKFDGGEEV 305


>gi|10190704 2,4-dienoyl CoA reductase 2 [Homo sapiens]
          Length = 292

 Score =  152 bits (385), Expect = 3e-37
 Identities = 90/258 (34%), Positives = 137/258 (53%), Gaps = 6/258 (2%)

Query: 8   RSYLAPGLLQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLP 67
           R    P LL+ +VA +TGG +GIG  I +  +  G + VIASR L R+ +AA +L     
Sbjct: 18  RHLFCPDLLRDKVAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAARKLAG--- 74

Query: 68  PTKQARVIPIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHISSKGWHAV 127
                R +P+  ++R    V   V   L  FG+I+ L+N   G FL PA  +S   +  V
Sbjct: 75  -ATGRRCLPLSMDVRAPPAVMAAVDQALKEFGRIDILINCAAGNFLCPAGALSFNAFKTV 133

Query: 128 LETNLTGTFYMCKAVYSSWMKEHGGSIVNIIVPT-KAGFPLAVHSGAARAGVYNLTKSLA 186
           ++ + +GTF + + +Y  + ++HGG IVNI       G  L VH+G+A+A V  +T+ LA
Sbjct: 134 MDIDTSGTFNVSRVLYEKFFRDHGGVIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLA 193

Query: 187 LEWACSGIRINCVAPGVIYSQTAVENYGSWGQSFFEGSFQKIPAKRIGVPEEVSSVVCFL 246
           +EW    IR+N +APG I     +   G   Q+         P +R+G   E++  V +L
Sbjct: 194 VEWGPQNIRVNSLAPGPISGTEGLRRLGG-PQASLSTKVTASPLQRLGNKTEIAHSVLYL 252

Query: 247 LSPAASFITGQSVDVDGG 264
            SP AS++TG  +  DGG
Sbjct: 253 ASPLASYVTGAVLVADGG 270


>gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo
           sapiens]
          Length = 278

 Score =  115 bits (288), Expect = 5e-26
 Identities = 82/253 (32%), Positives = 128/253 (50%), Gaps = 13/253 (5%)

Query: 16  LQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQARVI 75
           L  +VA+VT    GIG AI + L + G++VV++SRK + +  A   LQ      +   V 
Sbjct: 30  LANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQG-----EGLSVT 84

Query: 76  PIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGG-GQFLSPAEHISSKGWHAVLETNLTG 134
              C++   E+   LV + +   G I+ LV+N     F      ++ + W   L+ N+  
Sbjct: 85  GTVCHVGKAEDRERLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINVKA 144

Query: 135 TFYMCKAVYSSWMKEHGGSIVNIIVPTKAGF---PLAVHSGAARAGVYNLTKSLALEWAC 191
              M KAV     K  GGS+V  IV + A F   P       ++  +  LTK+LA+E A 
Sbjct: 145 PALMTKAVVPEMEKRGGGSVV--IVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAP 202

Query: 192 SGIRINCVAPGVIYSQTAVENYGSWGQSFFEGSFQKIPAKRIGVPEEVSSVVCFLLSPAA 251
             IR+NC+APG+I  +T+        +   E   + +  +R+G PE+ + +V FL S  A
Sbjct: 203 RNIRVNCLAPGLI--KTSFSRMLWMDKEKEESMKETLRIRRLGEPEDCAGIVSFLCSEDA 260

Query: 252 SFITGQSVDVDGG 264
           S+ITG++V V GG
Sbjct: 261 SYITGETVVVGGG 273


>gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo
           sapiens]
          Length = 280

 Score =  110 bits (276), Expect = 1e-24
 Identities = 80/258 (31%), Positives = 135/258 (52%), Gaps = 22/258 (8%)

Query: 14  GLLQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQAR 73
           G+L  +VA+VTG  +GIG AI + L   G++VVI+SRK + +  A  +LQ      +   
Sbjct: 32  GVLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQG-----EGLS 86

Query: 74  VIPIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGG-----GQFLSPAEHISSKGWHAVL 128
           V  I C++   E+   LV   L+  G ++FLV + G     G  L  +E I    W  +L
Sbjct: 87  VAGIVCHVGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQI----WDKIL 142

Query: 129 ETNLTGTFYMCKAVYSSWMKEHGGSIVNIIVPTKAGFPLAVHSG---AARAGVYNLTKSL 185
             N+     +   +   +M+   G++  I+V + A +   V  G    ++  +  LT++L
Sbjct: 143 SVNVKSPALLLSQLL-PYMENRRGAV--ILVSSIAAYNPVVALGVYNVSKTALLGLTRTL 199

Query: 186 ALEWACSGIRINCVAPGVIYSQTAVENYGSWGQSFFEGSFQKIPAKRIGVPEEVSSVVCF 245
           ALE A   IR+NCV PG+I +  +   +G+  +S ++   +    +RIG  E+ + +V F
Sbjct: 200 ALELAPKDIRVNCVVPGIIKTDFSKVFHGN--ESLWKNFKEHHQLQRIGESEDCAGIVSF 257

Query: 246 LLSPAASFITGQSVDVDG 263
           L SP AS++ G+++ V G
Sbjct: 258 LCSPDASYVNGENIAVAG 275


>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
           sapiens]
          Length = 270

 Score =  109 bits (273), Expect = 3e-24
 Identities = 83/255 (32%), Positives = 131/255 (51%), Gaps = 17/255 (6%)

Query: 18  GQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQARVIPI 77
           G+V +VTGG  GIG  IV+  +  G+ VVI  +     +S    L+  LP       + I
Sbjct: 9   GKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKD----ESGGRALEQELPGA-----VFI 59

Query: 78  QCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPA-EHISSKGWHAVLETNLTGTF 136
            C++  E++V  LV  T+  FG+++ +VNN G        E  S++G+  +LE NL GT+
Sbjct: 60  LCDVTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTY 119

Query: 137 YMCKAVYSSWMKEHGGSIVNIIVPTKA-GFPLAVHSGAARAGVYNLTKSLALEWACSGIR 195
            + K     ++++  G+++NI     A G   AV   A +  V  +TK+LAL+ +  G+R
Sbjct: 120 TLTKLALP-YLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVR 178

Query: 196 INCVAPGVIYSQTAVENYGSWGQ---SFFEGSFQKIPAKRIGVPEEVSSVVCFLLSPAAS 252
           +NC++PG I++    E          +  EG   + P  R+G P EV +   FL S  A+
Sbjct: 179 VNCISPGNIWTPLWEELAALMPDPRATIREGMLAQ-PLGRMGQPAEVGAAAVFLAS-EAN 236

Query: 253 FITGQSVDVDGGRSL 267
           F TG  + V GG  L
Sbjct: 237 FCTGIELLVTGGAEL 251


>gi|40254992 carbonic reductase 4 [Homo sapiens]
          Length = 237

 Score =  107 bits (267), Expect = 1e-23
 Identities = 79/252 (31%), Positives = 125/252 (49%), Gaps = 22/252 (8%)

Query: 19  QVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQARVIPIQ 78
           +V  V GG+ GIG+A+ + +   G  + + +R LE  K+AA +L  +         +   
Sbjct: 3   KVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGD--------HLAFS 54

Query: 79  CNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHISSKGWHAVLETNLTGTFYM 138
           C++  E +V N  +      G++NFLVN  G           ++   + L TNL G+   
Sbjct: 55  CDVAKEHDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLT 114

Query: 139 CKAVYSSWMKEHGGSIVNI--IVPTKAGFPLAVHSGAARAGVYNLTKSLALEWACSGIRI 196
           CKA   + +++ GGSIVN+  IV  K     +V+S A++ G+   +++LA E A   IR+
Sbjct: 115 CKAAMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYS-ASKGGLVGFSRALAKEVARKKIRV 173

Query: 197 NCVAPGVIYSQTAVENYGSWGQSFFEGSFQK-IPAKRIGVPEEVSSVVCFLLSPAASFIT 255
           N VAPG +++           +   E   +K IP  R G   EV+  V FLL   + +IT
Sbjct: 174 NVVAPGFVHTDMT--------KDLKEEHLKKNIPLGRFGETIEVAHAVVFLLE--SPYIT 223

Query: 256 GQSVDVDGGRSL 267
           G  + VDGG  L
Sbjct: 224 GHVLVVDGGLQL 235


>gi|126723750 dehydrogenase/reductase (SDR family) member 4 like 1
           [Homo sapiens]
          Length = 281

 Score = 94.7 bits (234), Expect = 9e-20
 Identities = 73/255 (28%), Positives = 121/255 (47%), Gaps = 14/255 (5%)

Query: 16  LQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQARVI 75
           L  +VA+VT     IG A+ + L + G++VV++ RK + +  A   LQ      +   + 
Sbjct: 30  LTNKVALVTASTDWIGFAVAQRLAQDGAHVVVSRRKQQNVDQAVATLQG-----EGLSMT 84

Query: 76  PIQCNIRNEEEVNNLVKSTLDTFGKINFL----VNNGGGQFLSPAEHISSKGWHAVLETN 131
              C++   ++   LV + +   G I+ L     N+  G F       + + W   L+ N
Sbjct: 85  GTVCHVGKMKDWERLVATAMKLHGVIDILSLSITNSKRGLFWFTLLQTAEEAWDRNLDIN 144

Query: 132 LTGTFYMCKAVYSSWMKEHGGSIVNIIVPTKAGFPLAVHS--GAARAGVYNLTKSLALEW 189
                 M KAV    M++ GG  V  +    A  PL   S    ++  +  L K+LA+E 
Sbjct: 145 GKALALMIKAVVPE-MEKRGGGSVGFLASVAAFRPLPGFSPYNVSKTALLGLNKTLAIEL 203

Query: 190 ACSGIRINCVAPGVIYSQTAVENYGSWGQSFFEGSFQKIPAKRIGVPEEVSSVVCFLLSP 249
           A   IR+NC+APG+I  +T+        +   E   + +  +R+G PE+   +V FL S 
Sbjct: 204 APRNIRVNCLAPGLI--KTSFSRMLWMDKEKEESMKETLRIRRLGEPEDSLGIVSFLCSE 261

Query: 250 AASFITGQSVDVDGG 264
            AS++TG++V V GG
Sbjct: 262 DASYLTGETVMVGGG 276


>gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo
           sapiens]
          Length = 300

 Score = 89.0 bits (219), Expect = 5e-18
 Identities = 80/258 (31%), Positives = 127/258 (49%), Gaps = 26/258 (10%)

Query: 14  GLLQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQAR 73
           G+L  +VA+VTG  +GIG AI + L   G++VVI+SRK + +  A  +LQ      +   
Sbjct: 32  GVLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQG-----EGLS 86

Query: 74  VIPIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGG-----GQFLSPAEHISSKGWHAVL 128
           V  I C++   E+   LV   L+  G ++FLV + G     G  L  +E I    W  +L
Sbjct: 87  VAGIVCHVGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQI----WDKIL 142

Query: 129 ETNLTGTFYMCKAVYSSWMKEHGGSIVNIIVPTKAGFPLAVHSG---AARAGVYNLTKSL 185
             N+     +   +   +M+   G++  I+V + A +   V  G    ++  +  LT++L
Sbjct: 143 SVNVKSPALLLSQLL-PYMENRRGAV--ILVSSIAAYNPVVALGVYNVSKTALLGLTRTL 199

Query: 186 ALEWACSGIRINCVAPGVIYSQ-TAVENYGSWGQSFFEGSFQKIPAKR-IGVPEEV--SS 241
           ALE A   IR+NCV PG+I +  + V   G  G S    + + I + R +G    V  S 
Sbjct: 200 ALELAPKDIRVNCVVPGIIKTDFSKVVRIGFMGMSLSGRTSRNIISCRGLGSQRTVQESC 259

Query: 242 VVCFLLSPAASFITGQSV 259
             C L  PA S  TG+++
Sbjct: 260 PSCALQMPATS--TGRTL 275


>gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]
          Length = 261

 Score = 88.2 bits (217), Expect = 8e-18
 Identities = 77/259 (29%), Positives = 118/259 (45%), Gaps = 19/259 (7%)

Query: 16  LQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQA--- 72
           L+  +A+VTG  +GIG+A+   L   G    +A+  L+R  +         P +K+    
Sbjct: 9   LRSALALVTGAGSGIGRAVSVRLA--GEGATVAACDLDRAAAQETVRLLGGPGSKEGPPR 66

Query: 73  -RVIPIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGG----QFLSPAEHISSKGWHAV 127
                 Q ++        L++     F +   +V +  G    +FL    H+S   W  V
Sbjct: 67  GNHAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLL---HMSEDDWDKV 123

Query: 128 LETNLTGTFYMCKAVYSSWMKEH-GGSIVNII-VPTKAGFPLAVHSGAARAGVYNLTKSL 185
           +  NL GTF + +A   + +     GSI+NI  +  K G     +  A++AGV  LT++ 
Sbjct: 124 IAVNLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTA 183

Query: 186 ALEWACSGIRINCVAPGVIYSQTAVENYGSWGQSFFEGSFQKIPAKRIGVPEEVSSVVCF 245
           A E    GIR N V PG I    A        Q   +   + IP   +G PE+V+ VV F
Sbjct: 184 ARELGRHGIRCNSVLPGFI----ATPMTQKVPQKVVDKITEMIPMGHLGDPEDVADVVAF 239

Query: 246 LLSPAASFITGQSVDVDGG 264
           L S  + +ITG SV+V GG
Sbjct: 240 LASEDSGYITGTSVEVTGG 258


>gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens]
          Length = 245

 Score = 80.1 bits (196), Expect = 2e-15
 Identities = 66/261 (25%), Positives = 113/261 (43%), Gaps = 24/261 (9%)

Query: 14  GLLQGQVAIVTGGATGIGKAIVKELLELGSNVV---IASRKLERLKSAADELQANLPPTK 70
           G L G+V I+T  A GIG+A        G+ V+   I   KL+ L+           P  
Sbjct: 2   GRLDGKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQELEKY---------PGI 52

Query: 71  QARVIPIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHISSKGWHAVLET 130
           Q RV+ +    + ++  N + +  LD    +   V++G             K W   +  
Sbjct: 53  QTRVLDVTKKKQIDQFANEVER--LDVLFNVAGFVHHG------TVLDCEEKDWDFSMNL 104

Query: 131 NLTGTFYMCKAVYSSWMKEHGGSIVNI--IVPTKAGFPLAVHSGAARAGVYNLTKSLALE 188
           N+   + M KA     + +  G+I+N+  +  +  G          +A V  LTKS+A +
Sbjct: 105 NVRSMYLMIKAFLPKMLAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAAD 164

Query: 189 WACSGIRINCVAPGVIYSQTAVENYGSWG--QSFFEGSFQKIPAKRIGVPEEVSSVVCFL 246
           +   GIR NCV PG + + +  E   + G  +       ++    R    EE++ +  +L
Sbjct: 165 FIQQGIRCNCVCPGTVDTPSLQERIQARGNPEEARNDFLKRQKTGRFATAEEIAMLCVYL 224

Query: 247 LSPAASFITGQSVDVDGGRSL 267
            S  ++++TG  V +DGG SL
Sbjct: 225 ASDESAYVTGNPVIIDGGWSL 245


>gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 1
           [Homo sapiens]
          Length = 266

 Score = 78.2 bits (191), Expect = 8e-15
 Identities = 58/197 (29%), Positives = 94/197 (47%), Gaps = 21/197 (10%)

Query: 16  LQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQARVI 75
           + G+VA+VTG A GIG+A  + LL  G+ V +    LE        L     P K    +
Sbjct: 3   VNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQK---TL 59

Query: 76  PIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHISSKGWHAVLETNLTGT 135
            IQC++ +++++ +  +  +D FG+++ LVNN G          + K W   L+ NL   
Sbjct: 60  FIQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVN--------NEKNWEKTLQINLVSV 111

Query: 136 F---YMCKAVYSSWMKEHGGSIVNIIVPTKAG-FPLAVHS--GAARAGVYNLTKS--LAL 187
               Y+     S      GG I+N  + + AG  P+A      A++ G+   T+S  LA 
Sbjct: 112 ISGTYLGLDYMSKQNGGEGGIIIN--MSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAA 169

Query: 188 EWACSGIRINCVAPGVI 204
               SG+R+N + PG +
Sbjct: 170 NLMNSGVRLNAICPGFV 186


>gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]
          Length = 260

 Score = 73.9 bits (180), Expect = 2e-13
 Identities = 66/247 (26%), Positives = 118/247 (47%), Gaps = 18/247 (7%)

Query: 19  QVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQ-ANLPPTKQARVIPI 77
           ++A+VTG + GIG A+ + L++ G  VV  +R +  ++  A E + A  P T    +IP 
Sbjct: 12  RLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGT----LIPY 67

Query: 78  QCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHISSKGWHAVLETNLTGTFY 137
           +C++ NEE++ ++  +       ++  +NN G          S+ GW  +   N+     
Sbjct: 68  RCDLSNEEDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNVNVLALSI 127

Query: 138 MCKAVYSSWMKEHG---GSIVNI-IVPTKAGFPLAV--HSGAARAGVYNLTKSL--ALEW 189
             +  Y S MKE     G I+NI  +      PL+V     A +  V  LT+ L   L  
Sbjct: 128 CTREAYQS-MKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQELRE 186

Query: 190 ACSGIRINCVAPGVIYSQTAVENYGSWGQSFFEGSFQKIPAKRIGVPEEVSSVVCFLLSP 249
           A + IR  C++PGV+ +Q A + +    +     +++++   +   PE+V+  V ++LS 
Sbjct: 187 AQTHIRATCISPGVVETQFAFKLHDKDPEK-AAATYEQMKCLK---PEDVAEAVIYVLST 242

Query: 250 AASFITG 256
            A    G
Sbjct: 243 PAHIQIG 249


>gi|126723191 dehydrogenase/reductase (SDR family) member 4 like 2
           [Homo sapiens]
          Length = 232

 Score = 73.6 bits (179), Expect = 2e-13
 Identities = 56/188 (29%), Positives = 87/188 (46%), Gaps = 11/188 (5%)

Query: 16  LQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQARVI 75
           L  +VA+VT    GIG AI + L +  ++VV++SRK + +  A   LQ      +   V 
Sbjct: 30  LTNKVALVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNVDQAVATLQG-----EGLSVT 84

Query: 76  PIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGG-GQFLSPAEHISSKGWHAVLETNLTG 134
              C++   E+   LV   +   G I+ LV+N     F      ++ + W   L+ N+  
Sbjct: 85  GTVCHVGKAEDRERLVAMAVKLHGGIDILVSNAAVNPFFGSLMDVTEEVWDKTLDINVKA 144

Query: 135 TFYMCKAVYSSWMKEHGGSIVNIIVPTKAGF---PLAVHSGAARAGVYNLTKSLALEWAC 191
              M KAV     K  GGS+V  IV + A F   P       ++  +  L  +LA+E A 
Sbjct: 145 PALMTKAVVPEMEKRGGGSVV--IVSSIAAFSPSPGFSPYNVSKTALLGLNNTLAIELAP 202

Query: 192 SGIRINCV 199
             IR+NC+
Sbjct: 203 RNIRVNCL 210


>gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Homo
           sapiens]
          Length = 311

 Score = 73.2 bits (178), Expect = 3e-13
 Identities = 55/231 (23%), Positives = 102/231 (44%), Gaps = 3/231 (1%)

Query: 16  LQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQARVI 75
           +Q +V ++T   +G+GK   +     G+ +V+  +  ERL++  D L +   P+K     
Sbjct: 35  VQNKVVVITDAISGLGKECARVFHTGGARLVLCGKNWERLENLYDALISVADPSKTFTPK 94

Query: 76  PIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHISSKGWHAVLETNLTGT 135
            +  ++ +   V ++ K  LD +G ++ L+NN   +   PA  IS +    +++ N  G 
Sbjct: 95  LVLLDLSDISCVPDVAKEVLDCYGCVDILINNASVKVKGPAHKISLELDKKIMDANYFGP 154

Query: 136 FYMCKAVYSSWMKEHGGSIVNI-IVPTKAGFPLAVHSGAARAGVYNLTKSLALEWACSGI 194
             + KA+  + +    G IV +  +  K G P      A++         L  E     +
Sbjct: 155 ITLTKALLPNMISRRTGQIVLVNNIQGKFGIPFRTTYAASKHAALGFFDCLRAEVEEYDV 214

Query: 195 RINCVAPGVIYSQTAVENYGSWGQSFFEGSFQKIP--AKRIGVPEEVSSVV 243
            I+ V+P  I S       G+W  S ++  F+K+      + V EEV   V
Sbjct: 215 VISTVSPTFIRSYHVYPEQGNWEASIWKFFFRKLTYGVHPVEVAEEVMRTV 265


>gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens]
          Length = 736

 Score = 72.0 bits (175), Expect = 6e-13
 Identities = 59/199 (29%), Positives = 95/199 (47%), Gaps = 16/199 (8%)

Query: 12  APGLLQGQVAIVTGGATGIGKAIVKELLELGSNVVIAS-----RKLERLKSAADELQANL 66
           +P    G+V +VTG   G+G+A      E G+ VV+       + + +   AAD++   +
Sbjct: 3   SPLRFDGRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVEEI 62

Query: 67  PPTKQARVIPIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHISSKGWHA 126
               + R      N  + EE   +VK+ LD FG+I+ +VNN G         IS + W  
Sbjct: 63  ----RRRGGKAVANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISDEDWDI 118

Query: 127 VLETNLTGTFYMCKAVYSSWMKEHGGSIVNIIVPTKAG----FPLAVHSGAARAGVYNLT 182
           +   +L G+F + +A +    K+  G I  I+  + +G    F  A +S AA+ G+  L 
Sbjct: 119 IHRVHLRGSFQVTRAAWEHMKKQKYGRI--IMTSSASGIYGNFGQANYS-AAKLGLLGLA 175

Query: 183 KSLALEWACSGIRINCVAP 201
            SLA+E   S I  N +AP
Sbjct: 176 NSLAIEGRKSNIHCNTIAP 194


>gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo
           sapiens]
          Length = 339

 Score = 68.2 bits (165), Expect = 9e-12
 Identities = 66/219 (30%), Positives = 98/219 (44%), Gaps = 20/219 (9%)

Query: 4   WAKGRSYLAPGLLQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRK---LERLKSAAD 60
           WA+ +       L   V  VTG ++GIG+ +  +L +LG ++V+++R+   LER+K    
Sbjct: 36  WAEWQGRRPEWELTDMVVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCL 95

Query: 61  ELQANLPPTKQARVIPIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHIS 120
           E   NL   K   V+P+        E     K+ L  FG+I+ LVNNGG    S     S
Sbjct: 96  E-NGNLKE-KDILVLPLDLTDTGSHEA--ATKAVLQEFGRIDILVNNGGMSQRSLCMDTS 151

Query: 121 SKGWHAVLETNLTGTFYMCKAVYSSWMKEHGGSIVN-------IIVPTKAGFPLAVHSGA 173
              +  ++E N  GT  + K V    ++   G IV        I VP   G+  + H  A
Sbjct: 152 LDVYRKLIELNYLGTVSLTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKH--A 209

Query: 174 ARAGVYNLTKSLALEWACSGIRINCVAPGVIYSQTAVEN 212
            R     L   LA      GI ++ + PG + S   VEN
Sbjct: 210 LRGFFNGLRTELA---TYPGIIVSNICPGPVQS-NIVEN 244


>gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 2
           [Homo sapiens]
          Length = 178

 Score = 67.8 bits (164), Expect = 1e-11
 Identities = 53/185 (28%), Positives = 85/185 (45%), Gaps = 19/185 (10%)

Query: 16  LQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQARVI 75
           + G+VA+VTG A GIG+A  + LL  G+ V +    LE        L     P K    +
Sbjct: 3   VNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQK---TL 59

Query: 76  PIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHISSKGWHAVLETNLTGT 135
            IQC++ +++++ +  +  +D FG+++ LVNN G          + K W   L+ NL   
Sbjct: 60  FIQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVN--------NEKNWEKTLQINLVSV 111

Query: 136 F---YMCKAVYSSWMKEHGGSIVNIIVPTKAG-FPLAVHS--GAARAGVYNLTKSLALEW 189
               Y+     S      GG I+N  + + AG  P+A      A++ G+   T+S A   
Sbjct: 112 ISGTYLGLDYMSKQNGGEGGIIIN--MSSLAGLMPVAQQPVYCASKHGIVGFTRSAAPTI 169

Query: 190 ACSGI 194
            C  I
Sbjct: 170 DCQWI 174


>gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens]
          Length = 244

 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 63/252 (25%), Positives = 107/252 (42%), Gaps = 19/252 (7%)

Query: 16  LQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQARVI 75
           L G+  +VTG   GIG+  V+ L   G+ VV  SR    L S   E            + 
Sbjct: 5   LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG---------IE 55

Query: 76  PIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHISSKGWHAVLETNLTGT 135
           P+  ++ + E      +  L + G ++ LVNN     L P   ++ + +    E NL   
Sbjct: 56  PVCVDLGDWE----ATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAV 111

Query: 136 FYMCKAVYSSWM-KEHGGSIVNIIVPTKAGFPLAVHS--GAARAGVYNLTKSLALEWACS 192
             + + V    + +   G+IVN+         +  HS   + +  +  LTK +ALE    
Sbjct: 112 IQVSQIVARGLIARGVPGAIVNVSSQCSQR-AVTNHSVYCSTKGALDMLTKVMALELGPH 170

Query: 193 GIRINCVAPGVIYSQTAVENYGSWGQSFFEGSFQKIPAKRIGVPEEVSSVVCFLLSPAAS 252
            IR+N V P V+ +      +    ++  +    +IP  +    E V + + FLLS  + 
Sbjct: 171 KIRVNAVNPTVVMTSMGQATWSDPHKA--KTMLNRIPLGKFAEVEHVVNAILFLLSDRSG 228

Query: 253 FITGQSVDVDGG 264
             TG ++ V+GG
Sbjct: 229 MTTGSTLPVEGG 240


>gi|40254986 hydroxysteroid dehydrogenase like 2 [Homo sapiens]
          Length = 418

 Score = 65.9 bits (159), Expect = 4e-11
 Identities = 44/154 (28%), Positives = 75/154 (48%), Gaps = 12/154 (7%)

Query: 14  GLLQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRK-------LERLKSAADELQANL 66
           G L G    +TG + GIGKAI  +  + G+N+VIA++        L  + +AA+E++A  
Sbjct: 6   GRLAGCTVFITGASRGIGKAIALKAAKDGANIVIAAKTAQPHPKLLGTIYTAAEEIEA-- 63

Query: 67  PPTKQARVIPIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHISSKGWHA 126
                 + +P   ++R+E++++  V+  +  FG I+ LVNN     L+      +K    
Sbjct: 64  ---VGGKALPCIVDVRDEQQISAAVEKAIKKFGGIDILVNNASAISLTNTLDTPTKRLDL 120

Query: 127 VLETNLTGTFYMCKAVYSSWMKEHGGSIVNIIVP 160
           ++  N  GT+   KA      K     I+NI  P
Sbjct: 121 MMNVNTRGTYLASKACIPYLKKSKVAHILNISPP 154


>gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo
           sapiens]
          Length = 332

 Score = 65.1 bits (157), Expect = 7e-11
 Identities = 47/183 (25%), Positives = 85/183 (46%), Gaps = 14/183 (7%)

Query: 13  PGLLQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQA 72
           P  L G   +VTGG++GIGK I  E  + G+ + + +R  ++L  A  E++ +    KQ 
Sbjct: 27  PLALPGAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSINDKQV 86

Query: 73  RVIPIQCNIRNE-EEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHISSKGWHAVLETN 131
            V+ I  ++  +  +V N++K   +  G ++ LVN  G       E +    +  ++  N
Sbjct: 87  -VLCISVDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFEDLEVSTFERLMSIN 145

Query: 132 LTGTFYMCKAVYSSWMKEHGGSIVNIIVPTKAGFPLAVHSGAARAGVYNLTKSLALEWAC 191
             G+ Y  +AV ++  +   G IV             V S A + G++  T   A ++A 
Sbjct: 146 YLGSVYPSRAVITTMKERRVGRIV------------FVSSQAGQLGLFGFTAYSASKFAI 193

Query: 192 SGI 194
            G+
Sbjct: 194 RGL 196


>gi|209862901 dehydrogenase/reductase (SDR family) member 1 [Homo
           sapiens]
          Length = 313

 Score = 64.3 bits (155), Expect = 1e-10
 Identities = 55/206 (26%), Positives = 89/206 (43%), Gaps = 15/206 (7%)

Query: 16  LQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQARVI 75
           + GQV +VTG + GIG+ I  +L + G+ V I  R L+ L+  A E Q     +   + +
Sbjct: 5   MNGQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQ-----SLGGQCV 59

Query: 76  PIQCNIRNEEEVNNLVKST-LDTFGKINFLVNN--GGGQFLSPAEH-----ISSKGWHAV 127
           P+ C+   E EV +L +    +  G+++ LVNN   G Q +    +       +  W  +
Sbjct: 60  PVVCDSSQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDI 119

Query: 128 LETNLTGTFYMCKAVYSSWMKEHG-GSIVNIIVPTKAGFPLAVHSGAARAGVYNLTKSLA 186
               L G  Y C    +  M   G G IV I  P    +   V  G  +A    L    A
Sbjct: 120 NNVGLRG-HYFCSVYGARLMVPAGQGLIVVISSPGSLQYMFNVPYGVGKAACDKLAADCA 178

Query: 187 LEWACSGIRINCVAPGVIYSQTAVEN 212
            E    G+    + PG++ ++   E+
Sbjct: 179 HELRRHGVSCVSLWPGIVQTELLKEH 204


>gi|19923983 dehydrogenase/reductase (SDR family) member 1 [Homo
           sapiens]
          Length = 313

 Score = 64.3 bits (155), Expect = 1e-10
 Identities = 55/206 (26%), Positives = 89/206 (43%), Gaps = 15/206 (7%)

Query: 16  LQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQARVI 75
           + GQV +VTG + GIG+ I  +L + G+ V I  R L+ L+  A E Q     +   + +
Sbjct: 5   MNGQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQ-----SLGGQCV 59

Query: 76  PIQCNIRNEEEVNNLVKST-LDTFGKINFLVNN--GGGQFLSPAEH-----ISSKGWHAV 127
           P+ C+   E EV +L +    +  G+++ LVNN   G Q +    +       +  W  +
Sbjct: 60  PVVCDSSQESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDI 119

Query: 128 LETNLTGTFYMCKAVYSSWMKEHG-GSIVNIIVPTKAGFPLAVHSGAARAGVYNLTKSLA 186
               L G  Y C    +  M   G G IV I  P    +   V  G  +A    L    A
Sbjct: 120 NNVGLRG-HYFCSVYGARLMVPAGQGLIVVISSPGSLQYMFNVPYGVGKAACDKLAADCA 178

Query: 187 LEWACSGIRINCVAPGVIYSQTAVEN 212
            E    G+    + PG++ ++   E+
Sbjct: 179 HELRRHGVSCVSLWPGIVQTELLKEH 204


>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
           sapiens]
          Length = 325

 Score = 63.5 bits (153), Expect = 2e-10
 Identities = 50/212 (23%), Positives = 87/212 (41%), Gaps = 7/212 (3%)

Query: 1   MASWAKGRSYLAPGLLQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAAD 60
           +  W +G++YL     +  V ++TG  +G+GK   K     G+ +V+  R    L+    
Sbjct: 40  LLQWVRGKAYL-----RNAVVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIR 94

Query: 61  ELQANLPPTKQA-RVIPIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHI 119
           EL A+     Q  +   +  ++ +   +       L  FG ++ LVNN G  +       
Sbjct: 95  ELTASHATKVQTHKPYLVTFDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDT 154

Query: 120 SSKGWHAVLETNLTGTFYMCKAVYSSWMKEHGGSIVNI-IVPTKAGFPLAVHSGAARAGV 178
           +      V+ETN  G   + KA+  S +K   G IV I  +  K   P      A++   
Sbjct: 155 TVDVDKRVMETNYFGPVALTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHAT 214

Query: 179 YNLTKSLALEWACSGIRINCVAPGVIYSQTAV 210
                 L  E     I +  ++PG I++  +V
Sbjct: 215 QAFFDCLRAEMEQYEIEVTVISPGYIHTNLSV 246


>gi|4557649 estradiol 17 beta-dehydrogenase 3 [Homo sapiens]
          Length = 310

 Score = 62.0 bits (149), Expect = 6e-10
 Identities = 61/205 (29%), Positives = 96/205 (46%), Gaps = 23/205 (11%)

Query: 18  GQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQARVIPI 77
           GQ A++TG   GIGKA   EL + G NVV+ SR LE+L++ A E++     T    V  I
Sbjct: 48  GQWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIER----TTGRSVKII 103

Query: 78  QCNIRNEEEVNNLVKSTLDTFGKINFLVNNGG-------GQFLSPAEHISSKGWHAVLET 130
           Q +   ++++   +K  L    +I  LVNN G         FL+  + I S     ++  
Sbjct: 104 QADF-TKDDIYEHIKEKLAGL-EIGILVNNVGMLPNLLPSHFLNAPDEIQS-----LIHC 156

Query: 131 NLTGTFYMCKAVYSSWMKEHGGSIVNIIVPTKAGFPLAVHS--GAARAGVYNLTKSLALE 188
           N+T    M + +         G I+NI     A FP  ++S   A++A V   +K+L  E
Sbjct: 157 NITSVVKMTQLILKHMESRQKGLILNISSGI-ALFPWPLYSMYSASKAFVCAFSKALQEE 215

Query: 189 WACSGIRINCVAPGVIYSQTAVENY 213
           +    + I  + P  +   TA+  Y
Sbjct: 216 YKAKEVIIQVLTPYAV--STAMTKY 238


>gi|4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1
           [Homo sapiens]
          Length = 261

 Score = 59.7 bits (143), Expect = 3e-09
 Identities = 63/262 (24%), Positives = 116/262 (44%), Gaps = 28/262 (10%)

Query: 16  LQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQARVI 75
           ++G VA++TGGA+G+G A  + L+  G++ V+       L ++  E QA          +
Sbjct: 8   VKGLVAVITGGASGLGLATAERLVGQGASAVLLD-----LPNSGGEAQAK---KLGNNCV 59

Query: 76  PIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHISSKGWHA------VLE 129
               ++ +E++V   +      FG+++  VN  G    S   ++     H       VL+
Sbjct: 60  FAPADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLD 119

Query: 130 TNLTGTFYMCKAVYSSWMK---EHGGSI-VNIIVPTKAGFPLAVHS---GAARAGVYNLT 182
            NL GTF + + V     +   + GG   V I   + A F   V      A++ G+  +T
Sbjct: 120 VNLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMT 179

Query: 183 KSLALEWACSGIRINCVAPGVIYSQTAVENYGSWGQSFFEGSFQKIP-AKRIGVPEEVSS 241
             +A + A  GIR+  +APG+  +        S  +        ++P   R+G P E + 
Sbjct: 180 LPIARDLAPIGIRVMTIAPGLFGTPLLT----SLPEKVCNFLASQVPFPSRLGDPAEYAH 235

Query: 242 VVCFLLSPAASFITGQSVDVDG 263
           +V  ++     F+ G+ + +DG
Sbjct: 236 LVQAIIE--NPFLNGEVIRLDG 255


>gi|186928839 retinol dehydrogenase 12 [Homo sapiens]
          Length = 316

 Score = 55.8 bits (133), Expect = 4e-08
 Identities = 48/205 (23%), Positives = 92/205 (44%), Gaps = 18/205 (8%)

Query: 16  LQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQARVI 75
           L G+V ++TG  TGIGK   +EL   G+ V IA R + + +SAA E++ +   TK ++V+
Sbjct: 37  LPGKVVVITGANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVD---TKNSQVL 93

Query: 76  PIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHISSKGWHAVLETNLTGT 135
             + ++ + + +    +  L    +++ L+NN G      ++  ++ G+   L  N  G 
Sbjct: 94  VRKLDLSDTKSIRAFAEGFLAEEKQLHILINNAGVMMCPYSK--TADGFETHLGVNHLGH 151

Query: 136 FYM-------------CKAVYSSWMKEHGGSIVNIIVPTKAGFPLAVHSGAARAGVYNLT 182
           F +              + V  S +  H G I    + ++  +        ++      T
Sbjct: 152 FLLTYLLLERLKVSAPARVVNVSSVAHHIGKIPFHDLQSEKRYSRGFAYCHSKLANVLFT 211

Query: 183 KSLALEWACSGIRINCVAPGVIYSQ 207
           + LA     +G+    V PGV+ S+
Sbjct: 212 RELAKRLQGTGVTTYAVHPGVVRSE 236


>gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A
           [Homo sapiens]
          Length = 300

 Score = 55.5 bits (132), Expect = 6e-08
 Identities = 47/190 (24%), Positives = 84/190 (44%), Gaps = 13/190 (6%)

Query: 18  GQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQARVIPI 77
           G++ ++TG   GIG+    E  +  S +V+       ++  A E +  L  T  A V+  
Sbjct: 36  GEIVLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAECR-KLGVTAHAYVV-- 92

Query: 78  QCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHISSKGWH--AVLETNLTGT 135
             +  N EE+   +       G +  +VNN G  +  PA+ +S+K        E N+ G 
Sbjct: 93  --DCSNREEIYRSLNQVKKEVGDVTIVVNNAGTVY--PADLLSTKDEEITKTFEVNILGH 148

Query: 136 FYMCKAVYSSWMKEHGGSIVNII-VPTKAGFPLAVHSGAARAGVYNLTKSLALEWAC--- 191
           F++ KA+  S M+ + G IV +  V    G P  +   +++       + L  E      
Sbjct: 149 FWITKALLPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQALGK 208

Query: 192 SGIRINCVAP 201
           +GI+ +C+ P
Sbjct: 209 TGIKTSCLCP 218


>gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo
           sapiens]
          Length = 302

 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 48/193 (24%), Positives = 79/193 (40%), Gaps = 16/193 (8%)

Query: 16  LQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLER-LKSAADELQANLPPTKQARV 74
           L  +  ++TGG  GIG+ + +E  E G+  ++   + E+ LK   +E++           
Sbjct: 36  LSRENVLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIR-----QMGTEC 90

Query: 75  IPIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNG----GGQFLSPAEHISSKGWHAVLET 130
               C++ N EEV    K+  +  G I  LVNN     G   +   +    K  H     
Sbjct: 91  HYFICDVGNREEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQH----I 146

Query: 131 NLTGTFYMCKAVYSSWMKEHGGSIVNI-IVPTKAGFPLAVHSGAARAGVYNLTKSLALEW 189
           N  G F+  KA     ++   G IV +  V   +  P A+    ++A  +   +SL L  
Sbjct: 147 NTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGL 206

Query: 190 A-CSGIRINCVAP 201
             C G+    V P
Sbjct: 207 LDCPGVSATTVLP 219


>gi|226371731 hydroxysteroid dehydrogenase like 1 isoform a [Homo
           sapiens]
          Length = 330

 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 52/204 (25%), Positives = 89/204 (43%), Gaps = 17/204 (8%)

Query: 18  GQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQARVIPI 77
           G+ A+V+G   GIGKA  +EL   G N+++ SR  E+L+  A +    +  T +     I
Sbjct: 67  GRWAVVSGATDGIGKAYAEELASRGLNIILISRNEEKLQVVAKD----IADTYKVETDII 122

Query: 78  QCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPA--EHISSKGWHAVLETNLTGT 135
             +  +  E+   ++  L     +  LVNN G  +  P     +S      ++  N+   
Sbjct: 123 VADFSSGREIYLPIREALKD-KDVGILVNNVGVFYPYPQYFTQLSEDKLWDIINVNIAAA 181

Query: 136 FYMCKAVYSSWMKEHGGSIVNI-----IVPTKAGFPLAVHSGAARAGVYNLTKSLALEWA 190
             M   V    ++   G+IV I       PT    P      A++A + + +++L  E+A
Sbjct: 182 SLMVHVVLPGMVERKKGAIVTISSGSCCKPT----PQLAAFSASKAYLDHFSRALQYEYA 237

Query: 191 CSGIRINCVAP-GVIYSQTAVENY 213
             GI +  + P  V  S TA  N+
Sbjct: 238 SKGIFVQSLIPFYVATSMTAPSNF 261


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.133    0.395 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,744,596
Number of Sequences: 37866
Number of extensions: 508646
Number of successful extensions: 1159
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 51
Number of HSP's successfully gapped in prelim test: 29
Number of HSP's that attempted gapping in prelim test: 1037
Number of HSP's gapped (non-prelim): 86
length of query: 303
length of database: 18,247,518
effective HSP length: 102
effective length of query: 201
effective length of database: 14,385,186
effective search space: 2891422386
effective search space used: 2891422386
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.