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Search of human proteins with 19923729
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|19923729 leucine rich repeat containing 8 family, member C
[Homo sapiens]
(803 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|19923729 leucine rich repeat containing 8 family, member C [H... 1606 0.0
gi|40217803 leucine rich repeat containing 8 family, member E [H... 1008 0.0
gi|62241040 leucine rich repeat containing 8 family, member A [H... 956 0.0
gi|187829877 leucine rich repeat containing 8 family, member A [... 956 0.0
gi|187829871 leucine rich repeat containing 8 family, member A [... 956 0.0
gi|197333706 leucine rich repeat containing 8 family, member D [... 858 0.0
gi|34222199 leucine rich repeat containing 8 family, member D [H... 858 0.0
gi|197333692 leucine rich repeat containing 8 family, member B [... 831 0.0
gi|21245134 leucine rich repeat containing 8 family, member B [H... 831 0.0
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 120 7e-27
gi|16904383 leucine rich repeat containing 7 [Homo sapiens] 118 2e-26
gi|238908508 leucine-rich repeat and death domain-containing pro... 115 1e-25
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 112 1e-24
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens] 112 1e-24
gi|45827729 scribble isoform b [Homo sapiens] 110 7e-24
gi|45827731 scribble isoform a [Homo sapiens] 110 7e-24
gi|95113664 leucine rich repeat containing 1 [Homo sapiens] 103 6e-22
gi|4503743 flightless I homolog [Homo sapiens] 100 5e-21
gi|33285015 leucine rich repeat containing 28 [Homo sapiens] 97 5e-20
gi|61742786 leucine rich repeat and death domain containing prot... 97 8e-20
gi|61742784 leucine rich repeat and death domain containing prot... 97 8e-20
gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens] 95 2e-19
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 95 3e-19
gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom... 92 2e-18
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 89 2e-17
gi|61742782 leucine rich repeat and death domain containing prot... 87 8e-17
gi|193788651 leucine rich repeat containing 69 [Homo sapiens] 84 4e-16
gi|21389431 leucine rich repeat containing 39 [Homo sapiens] 82 2e-15
gi|154091020 leucine-rich repeats and calponin homology (CH) dom... 81 4e-15
gi|34577083 ras suppressor protein 1 isoform 2 [Homo sapiens] 80 6e-15
>gi|19923729 leucine rich repeat containing 8 family, member C [Homo
sapiens]
Length = 803
Score = 1606 bits (4158), Expect = 0.0
Identities = 803/803 (100%), Positives = 803/803 (100%)
Query: 1 MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIICLPKRVQ 60
MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIICLPKRVQ
Sbjct: 1 MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIICLPKRVQ 60
Query: 61 PAQNHSSLSNVSQAVASTTPLPPPKPSPANPITVEMKGLKTDLDLQQYSFINQMCYERAL 120
PAQNHSSLSNVSQAVASTTPLPPPKPSPANPITVEMKGLKTDLDLQQYSFINQMCYERAL
Sbjct: 61 PAQNHSSLSNVSQAVASTTPLPPPKPSPANPITVEMKGLKTDLDLQQYSFINQMCYERAL 120
Query: 121 HWYAKYFPYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFISILGKCFDSPWTTRALSEVSG 180
HWYAKYFPYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFISILGKCFDSPWTTRALSEVSG
Sbjct: 121 HWYAKYFPYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFISILGKCFDSPWTTRALSEVSG 180
Query: 181 EDSEEKDNRKNNMNRSNTIQSGPEGSLVNSQSLKSIPEKFVVDKSTAGALDKKEGEQAKA 240
EDSEEKDNRKNNMNRSNTIQSGPEGSLVNSQSLKSIPEKFVVDKSTAGALDKKEGEQAKA
Sbjct: 181 EDSEEKDNRKNNMNRSNTIQSGPEGSLVNSQSLKSIPEKFVVDKSTAGALDKKEGEQAKA 240
Query: 241 LFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVDCNVDIQDM 300
LFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVDCNVDIQDM
Sbjct: 241 LFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVDCNVDIQDM 300
Query: 301 TGYKNFSCNHTMAHLFSKLSFCYLCFVSIYGLTCLYTLYWLFYRSLREYSFEYVRQETGI 360
TGYKNFSCNHTMAHLFSKLSFCYLCFVSIYGLTCLYTLYWLFYRSLREYSFEYVRQETGI
Sbjct: 301 TGYKNFSCNHTMAHLFSKLSFCYLCFVSIYGLTCLYTLYWLFYRSLREYSFEYVRQETGI 360
Query: 361 DDIPDVKNDFAFMLHMIDQYDPLYSKRFAVFLSEVSENKLKQLNLNNEWTPDKLRQKLQT 420
DDIPDVKNDFAFMLHMIDQYDPLYSKRFAVFLSEVSENKLKQLNLNNEWTPDKLRQKLQT
Sbjct: 361 DDIPDVKNDFAFMLHMIDQYDPLYSKRFAVFLSEVSENKLKQLNLNNEWTPDKLRQKLQT 420
Query: 421 NAHNRLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVK 480
NAHNRLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVK
Sbjct: 421 NAHNRLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVK 480
Query: 481 IHSAALSFLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRD 540
IHSAALSFLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRD
Sbjct: 481 IHSAALSFLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRD 540
Query: 541 LKSLKILSIKSNVSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCD 600
LKSLKILSIKSNVSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCD
Sbjct: 541 LKSLKILSIKSNVSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCD 600
Query: 601 LERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLT 660
LERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLT
Sbjct: 601 LERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLT 660
Query: 661 SLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVES 720
SLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVES
Sbjct: 661 SLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVES 720
Query: 721 LPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALKRA 780
LPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALKRA
Sbjct: 721 LPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALKRA 780
Query: 781 GLVVEDALFETLPSDVREQMKTE 803
GLVVEDALFETLPSDVREQMKTE
Sbjct: 781 GLVVEDALFETLPSDVREQMKTE 803
>gi|40217803 leucine rich repeat containing 8 family, member E [Homo
sapiens]
Length = 796
Score = 1008 bits (2607), Expect = 0.0
Identities = 496/805 (61%), Positives = 625/805 (77%), Gaps = 11/805 (1%)
Query: 1 MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIICLPKRVQ 60
MIPV EF+QF+EQQPAF+VLKPWWDV +YL+VAMLMIGVFGCTLQV QDKIICLP
Sbjct: 1 MIPVAEFKQFTEQQPAFKVLKPWWDVLAEYLTVAMLMIGVFGCTLQVTQDKIICLP---- 56
Query: 61 PAQNHSSLSNVSQAVASTTPLPPPKPSPANPITVEMKGLKTDLDLQQYSFINQMCYERAL 120
NH N+S+A LP P + E+KGLK +LDLQQYSFINQ+CYE AL
Sbjct: 57 ---NHELQENLSEAPCQQL-LPRGIPEQIGALQ-EVKGLKNNLDLQQYSFINQLCYETAL 111
Query: 121 HWYAKYFPYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFISILGKCFDSPWTTRALSEVSG 180
HWYAKYFPYLV+IHTL+FM+C++FWFKFPG+SSKIEHFISILGKCFDSPWTTRALSEVSG
Sbjct: 112 HWYAKYFPYLVVIHTLIFMVCTSFWFKFPGTSSKIEHFISILGKCFDSPWTTRALSEVSG 171
Query: 181 EDSEEKDNRKNNMNRSNTIQSGPEGSLVNSQSLKSI--PEKFVVDKSTAGALDKKEGEQA 238
E+ + + + G + K + PEK V + LDKKEGEQA
Sbjct: 172 ENQKGPAATERAAATIVAMAGTGPGKAGEGEKEKVLAEPEKVVTEPPVVTLLDKKEGEQA 231
Query: 239 KALFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVDCNVDIQ 298
KALFEKVKKFR+HVEEGDILY MY+RQTVLKV KFL I+ YN V K+ F V C V+
Sbjct: 232 KALFEKVKKFRMHVEEGDILYTMYIRQTVLKVCKFLAILVYNLVYVEKISFLVACRVETS 291
Query: 299 DMTGYKNFSCNHTMAHLFSKLSFCYLCFVSIYGLTCLYTLYWLFYRSLREYSFEYVRQET 358
++TGY +F CNHT AHLFSKL+FCY+ FV IYGLTC+YTLYWLF+R L+EYSF VR+ET
Sbjct: 292 EVTGYASFCCNHTKAHLFSKLAFCYISFVCIYGLTCIYTLYWLFHRPLKEYSFRSVREET 351
Query: 359 GIDDIPDVKNDFAFMLHMIDQYDPLYSKRFAVFLSEVSENKLKQLNLNNEWTPDKLRQKL 418
G+ DIPDVKNDFAFMLH+IDQYD LYSKRFAVFLSEVSE++LKQLNLN+EWTP+KLRQKL
Sbjct: 352 GMGDIPDVKNDFAFMLHLIDQYDSLYSKRFAVFLSEVSESRLKQLNLNHEWTPEKLRQKL 411
Query: 419 QTNAHNRLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCS 478
Q NA RLEL L ML GLPDTVFE++E++SL+LE I ++ P ++QL +LQELSL
Sbjct: 412 QRNAAGRLELALCMLPGLPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLLHSP 471
Query: 479 VKIHSAALSFLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESL 538
++ + FL+++LKV+ VK +++RE+P W++GLR LEEL+L G +++R TLESL
Sbjct: 472 ARLPFSLQVFLRDHLKVMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATLESL 531
Query: 539 RDLKSLKILSIKSNVSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVH 598
R+LK LK+LS++SN K+P +V DV+ HLQ++ +HNDG +LV LN+LKK+ L ELELV
Sbjct: 532 RELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVA 591
Query: 599 CDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKK 658
C LERIPHAVFSL +LQELDLK+N+L+SIEEI+SFQH RKL L+LWHN I Y+PEH++K
Sbjct: 592 CGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRK 651
Query: 659 LTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKV 718
L SLE+L S+NK+E LPS L LC+ +R LD+S+N + +PPE+G+LQ+LQ+ +++ N +
Sbjct: 652 LRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNAL 711
Query: 719 ESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALK 778
E+LP+EL+FC+KL+TL +G N LS LSP +G L LS L++KGN E LP ELG+C LK
Sbjct: 712 EALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGLK 771
Query: 779 RAGLVVEDALFETLPSDVREQMKTE 803
+AGL+VED L++ LP++VR++M+ E
Sbjct: 772 KAGLLVEDTLYQGLPAEVRDKMEEE 796
>gi|62241040 leucine rich repeat containing 8 family, member A [Homo
sapiens]
Length = 810
Score = 956 bits (2471), Expect = 0.0
Identities = 466/806 (57%), Positives = 614/806 (76%), Gaps = 10/806 (1%)
Query: 1 MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIICLPKR-- 58
MIPVTE R F++ QPA+R+LKPWWDVFTDY+S+ MLMI VFG TLQV QDK+ICLP +
Sbjct: 1 MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPCKWV 60
Query: 59 VQPAQNHSSLSNVSQAVASTTPLPPPKPSPANPITVEMKGLKTDLDLQQYSFINQMCYER 118
+ + N S + T P P+P T G+K DLD QY++++ +CYE
Sbjct: 61 TKDSCNDSFRGWAAPGPEPTYPNSTILPTPDTGPT----GIKYDLDRHQYNYVDAVCYEN 116
Query: 119 ALHWYAKYFPYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFISILGKCFDSPWTTRALSEV 178
LHW+AKYFPYLVL+HTL+F+ CSNFWFKFP +SSK+EHF+SIL KCFDSPWTTRALSE
Sbjct: 117 RLHWFAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSET 176
Query: 179 SGEDSEEKD--NRKNNM--NRSNTIQSGPEGSLVNSQSLKSIPEKFVVDKSTAGALDKKE 234
E+S+ K ++ N +S+T+ E ++ Q KS E+ +VD+S G LDKKE
Sbjct: 177 VVEESDPKPAFSKMNGSMDKKSSTVSEDVEATVPMLQRTKSRIEQGIVDRSETGVLDKKE 236
Query: 235 GEQAKALFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVDCN 294
GEQAKALFEKVKKFR HVEEGDI+Y +Y+RQT++KVIKF++II Y V ++F VDC
Sbjct: 237 GEQAKALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFILIICYTVYYVHNIKFDVDCT 296
Query: 295 VDIQDMTGYKNFSCNHTMAHLFSKLSFCYLCFVSIYGLTCLYTLYWLFYRSLREYSFEYV 354
VDI+ +TGY+ + C H +A LF L+ Y+ V YGL C+YTL+W+ RSL++YSFE +
Sbjct: 297 VDIESLTGYRTYRCAHPLATLFKILASFYISLVIFYGLICMYTLWWMLRRSLKKYSFESI 356
Query: 355 RQETGIDDIPDVKNDFAFMLHMIDQYDPLYSKRFAVFLSEVSENKLKQLNLNNEWTPDKL 414
R+E+ DIPDVKNDFAFMLH+IDQYDPLYSKRFAVFLSEVSENKL+QLNLNNEWT DKL
Sbjct: 357 REESSYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKL 416
Query: 415 RQKLQTNAHNRLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSL 474
RQ+L NA ++LEL L MLSG+PDTVF++ EL+ LKLE+I +V IP +IAQL L+EL L
Sbjct: 417 RQRLTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWL 476
Query: 475 HQCSVKIHSAALSFLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVT 534
+ + KI + AL+FL+ENL+ L +KF D++E+P W+Y L+ LEEL+L G+LS + +R +
Sbjct: 477 YHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIV 536
Query: 535 LESLRDLKSLKILSIKSNVSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTEL 594
++ LR+LK LK+L +KSN+SK+PQ V DV HLQK+ I+N+GTKL++LN+LKKM NLTEL
Sbjct: 537 IDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTEL 596
Query: 595 ELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPE 654
EL+ CDLERIPH++FSL +LQE+DLK+NNLK+IEEI+SFQHL +LT LKLW+N I YIP
Sbjct: 597 ELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPI 656
Query: 655 HIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSIT 714
I LT+LERL + NKIE +P+ LF C K+RYLDLS+N++ F+P +IG+LQ+LQ +IT
Sbjct: 657 QIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAIT 716
Query: 715 CNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDC 774
N++E+LP EL+ C+KL+ L +G N L L ++G L L+ ++++GN E LP ELG+C
Sbjct: 717 ANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGEC 776
Query: 775 RALKRAGLVVEDALFETLPSDVREQM 800
LKR+GLVVE+ LF TLP +V+E++
Sbjct: 777 PLLKRSGLVVEEDLFNTLPPEVKERL 802
>gi|187829877 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 956 bits (2471), Expect = 0.0
Identities = 466/806 (57%), Positives = 614/806 (76%), Gaps = 10/806 (1%)
Query: 1 MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIICLPKR-- 58
MIPVTE R F++ QPA+R+LKPWWDVFTDY+S+ MLMI VFG TLQV QDK+ICLP +
Sbjct: 1 MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPCKWV 60
Query: 59 VQPAQNHSSLSNVSQAVASTTPLPPPKPSPANPITVEMKGLKTDLDLQQYSFINQMCYER 118
+ + N S + T P P+P T G+K DLD QY++++ +CYE
Sbjct: 61 TKDSCNDSFRGWAAPGPEPTYPNSTILPTPDTGPT----GIKYDLDRHQYNYVDAVCYEN 116
Query: 119 ALHWYAKYFPYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFISILGKCFDSPWTTRALSEV 178
LHW+AKYFPYLVL+HTL+F+ CSNFWFKFP +SSK+EHF+SIL KCFDSPWTTRALSE
Sbjct: 117 RLHWFAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSET 176
Query: 179 SGEDSEEKD--NRKNNM--NRSNTIQSGPEGSLVNSQSLKSIPEKFVVDKSTAGALDKKE 234
E+S+ K ++ N +S+T+ E ++ Q KS E+ +VD+S G LDKKE
Sbjct: 177 VVEESDPKPAFSKMNGSMDKKSSTVSEDVEATVPMLQRTKSRIEQGIVDRSETGVLDKKE 236
Query: 235 GEQAKALFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVDCN 294
GEQAKALFEKVKKFR HVEEGDI+Y +Y+RQT++KVIKF++II Y V ++F VDC
Sbjct: 237 GEQAKALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFILIICYTVYYVHNIKFDVDCT 296
Query: 295 VDIQDMTGYKNFSCNHTMAHLFSKLSFCYLCFVSIYGLTCLYTLYWLFYRSLREYSFEYV 354
VDI+ +TGY+ + C H +A LF L+ Y+ V YGL C+YTL+W+ RSL++YSFE +
Sbjct: 297 VDIESLTGYRTYRCAHPLATLFKILASFYISLVIFYGLICMYTLWWMLRRSLKKYSFESI 356
Query: 355 RQETGIDDIPDVKNDFAFMLHMIDQYDPLYSKRFAVFLSEVSENKLKQLNLNNEWTPDKL 414
R+E+ DIPDVKNDFAFMLH+IDQYDPLYSKRFAVFLSEVSENKL+QLNLNNEWT DKL
Sbjct: 357 REESSYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKL 416
Query: 415 RQKLQTNAHNRLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSL 474
RQ+L NA ++LEL L MLSG+PDTVF++ EL+ LKLE+I +V IP +IAQL L+EL L
Sbjct: 417 RQRLTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWL 476
Query: 475 HQCSVKIHSAALSFLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVT 534
+ + KI + AL+FL+ENL+ L +KF D++E+P W+Y L+ LEEL+L G+LS + +R +
Sbjct: 477 YHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIV 536
Query: 535 LESLRDLKSLKILSIKSNVSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTEL 594
++ LR+LK LK+L +KSN+SK+PQ V DV HLQK+ I+N+GTKL++LN+LKKM NLTEL
Sbjct: 537 IDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTEL 596
Query: 595 ELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPE 654
EL+ CDLERIPH++FSL +LQE+DLK+NNLK+IEEI+SFQHL +LT LKLW+N I YIP
Sbjct: 597 ELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPI 656
Query: 655 HIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSIT 714
I LT+LERL + NKIE +P+ LF C K+RYLDLS+N++ F+P +IG+LQ+LQ +IT
Sbjct: 657 QIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAIT 716
Query: 715 CNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDC 774
N++E+LP EL+ C+KL+ L +G N L L ++G L L+ ++++GN E LP ELG+C
Sbjct: 717 ANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGEC 776
Query: 775 RALKRAGLVVEDALFETLPSDVREQM 800
LKR+GLVVE+ LF TLP +V+E++
Sbjct: 777 PLLKRSGLVVEEDLFNTLPPEVKERL 802
>gi|187829871 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 956 bits (2471), Expect = 0.0
Identities = 466/806 (57%), Positives = 614/806 (76%), Gaps = 10/806 (1%)
Query: 1 MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIICLPKR-- 58
MIPVTE R F++ QPA+R+LKPWWDVFTDY+S+ MLMI VFG TLQV QDK+ICLP +
Sbjct: 1 MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPCKWV 60
Query: 59 VQPAQNHSSLSNVSQAVASTTPLPPPKPSPANPITVEMKGLKTDLDLQQYSFINQMCYER 118
+ + N S + T P P+P T G+K DLD QY++++ +CYE
Sbjct: 61 TKDSCNDSFRGWAAPGPEPTYPNSTILPTPDTGPT----GIKYDLDRHQYNYVDAVCYEN 116
Query: 119 ALHWYAKYFPYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFISILGKCFDSPWTTRALSEV 178
LHW+AKYFPYLVL+HTL+F+ CSNFWFKFP +SSK+EHF+SIL KCFDSPWTTRALSE
Sbjct: 117 RLHWFAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSET 176
Query: 179 SGEDSEEKD--NRKNNM--NRSNTIQSGPEGSLVNSQSLKSIPEKFVVDKSTAGALDKKE 234
E+S+ K ++ N +S+T+ E ++ Q KS E+ +VD+S G LDKKE
Sbjct: 177 VVEESDPKPAFSKMNGSMDKKSSTVSEDVEATVPMLQRTKSRIEQGIVDRSETGVLDKKE 236
Query: 235 GEQAKALFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVDCN 294
GEQAKALFEKVKKFR HVEEGDI+Y +Y+RQT++KVIKF++II Y V ++F VDC
Sbjct: 237 GEQAKALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFILIICYTVYYVHNIKFDVDCT 296
Query: 295 VDIQDMTGYKNFSCNHTMAHLFSKLSFCYLCFVSIYGLTCLYTLYWLFYRSLREYSFEYV 354
VDI+ +TGY+ + C H +A LF L+ Y+ V YGL C+YTL+W+ RSL++YSFE +
Sbjct: 297 VDIESLTGYRTYRCAHPLATLFKILASFYISLVIFYGLICMYTLWWMLRRSLKKYSFESI 356
Query: 355 RQETGIDDIPDVKNDFAFMLHMIDQYDPLYSKRFAVFLSEVSENKLKQLNLNNEWTPDKL 414
R+E+ DIPDVKNDFAFMLH+IDQYDPLYSKRFAVFLSEVSENKL+QLNLNNEWT DKL
Sbjct: 357 REESSYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKL 416
Query: 415 RQKLQTNAHNRLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSL 474
RQ+L NA ++LEL L MLSG+PDTVF++ EL+ LKLE+I +V IP +IAQL L+EL L
Sbjct: 417 RQRLTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWL 476
Query: 475 HQCSVKIHSAALSFLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVT 534
+ + KI + AL+FL+ENL+ L +KF D++E+P W+Y L+ LEEL+L G+LS + +R +
Sbjct: 477 YHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIV 536
Query: 535 LESLRDLKSLKILSIKSNVSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTEL 594
++ LR+LK LK+L +KSN+SK+PQ V DV HLQK+ I+N+GTKL++LN+LKKM NLTEL
Sbjct: 537 IDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTEL 596
Query: 595 ELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPE 654
EL+ CDLERIPH++FSL +LQE+DLK+NNLK+IEEI+SFQHL +LT LKLW+N I YIP
Sbjct: 597 ELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPI 656
Query: 655 HIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSIT 714
I LT+LERL + NKIE +P+ LF C K+RYLDLS+N++ F+P +IG+LQ+LQ +IT
Sbjct: 657 QIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAIT 716
Query: 715 CNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDC 774
N++E+LP EL+ C+KL+ L +G N L L ++G L L+ ++++GN E LP ELG+C
Sbjct: 717 ANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGEC 776
Query: 775 RALKRAGLVVEDALFETLPSDVREQM 800
LKR+GLVVE+ LF TLP +V+E++
Sbjct: 777 PLLKRSGLVVEEDLFNTLPPEVKERL 802
>gi|197333706 leucine rich repeat containing 8 family, member D
[Homo sapiens]
Length = 858
Score = 858 bits (2216), Expect = 0.0
Identities = 428/849 (50%), Positives = 582/849 (68%), Gaps = 46/849 (5%)
Query: 1 MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIICLPKRVQ 60
M + E ++ QP +R+LKPWWDVF DYL+V MLM+ +F T+Q+ +D+++CLP
Sbjct: 1 MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPS 60
Query: 61 PA---------------------------QNHSSLSNVSQAVASTTPLPP-----PKPSP 88
P Q+ + +++S ++ TP P P+
Sbjct: 61 PVNSKAHTPPGNAEVTTNIPKMEAATNQDQDGRTTNDISFGTSAVTPDIPLRATYPRTDF 120
Query: 89 ANPITVEMK------GLKTDLDLQQYSFINQMCYERALHWYAKYFPYLVLIHTLVFMLCS 142
A P K G KT+LD QQY FINQMCY AL WY+KYFPYL LIHT++ M+ S
Sbjct: 121 ALPNQEAKKEKKDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSS 180
Query: 143 NFWFKFPGSSSKIEHFISILGKCFDSPWTTRALSEVSGEDSEEKDNRKNNMNR--SNTIQ 200
NFWFK+P + SK+EHF+SILGKCF+SPWTT+ALSE + EDSEE R +
Sbjct: 181 NFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVST 240
Query: 201 SGPEGS------LVNSQSLKSIPEKFVVDKSTAGALDKKEGEQAKALFEKVKKFRLHVEE 254
S EGS ++N K EK V++ + LDKK+GEQAKALFEKV+KFR HVE+
Sbjct: 241 SSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVED 300
Query: 255 GDILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVDCNVDIQDMTGYKNFSCNHTMAH 314
D++Y +YV QTV+K KF+ I+ Y + V+ + F C ++ + GY+ F C H MA+
Sbjct: 301 SDLIYKLYVVQTVIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMAY 360
Query: 315 LFSKLSFCYLCFVSIYGLTCLYTLYWLFYRSLREYSFEYVRQETGIDDIPDVKNDFAFML 374
+ KL Y+ + +YG CLYTL+WLF L+EYSFE VR+E+ DIPDVKNDFAF+L
Sbjct: 361 MLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLL 420
Query: 375 HMIDQYDPLYSKRFAVFLSEVSENKLKQLNLNNEWTPDKLRQKLQTNAHNRLELPLIMLS 434
HM+DQYD LYSKRF VFLSEVSENKL++++LN+EWT +KLRQ + NA ++ EL L MLS
Sbjct: 421 HMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLS 480
Query: 435 GLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKENLK 494
G+PD VF++T+L LKLE+I IPA I+Q+ NLQEL L C K+ A SFL+++L+
Sbjct: 481 GVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLR 540
Query: 495 VLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRDLKSLKILSIKSNVS 554
L VKF D+ E+P W+Y L+NL ELYL+G+L+ + ++ + LESLR+L+ LKIL +KSN++
Sbjct: 541 CLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLT 600
Query: 555 KIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSLLSL 614
K+P + DV+ HL K+ IHNDGTKL++LN+LKKM N+ ELEL +C+LERIPHA+FSL +L
Sbjct: 601 KVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNL 660
Query: 615 QELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEV 674
QELDLK NN+++IEEI+SFQHL++LT LKLWHN I IP I + +LE L FS+NK+E
Sbjct: 661 QELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLES 720
Query: 675 LPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTL 734
LP +F K+R LD+SYN+I IP EIG+LQ+LQ+ IT NKV+ LP +L+ C KL+TL
Sbjct: 721 LPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTL 780
Query: 735 KIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALKRAGLVVEDALFETLPS 794
+G+N ++ L K+G L L+ L++KGN + LP +LG CR LK++GLVVED LF+TLP
Sbjct: 781 NLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPL 840
Query: 795 DVREQMKTE 803
+V+E + +
Sbjct: 841 EVKEALNQD 849
>gi|34222199 leucine rich repeat containing 8 family, member D [Homo
sapiens]
Length = 858
Score = 858 bits (2216), Expect = 0.0
Identities = 428/849 (50%), Positives = 582/849 (68%), Gaps = 46/849 (5%)
Query: 1 MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIICLPKRVQ 60
M + E ++ QP +R+LKPWWDVF DYL+V MLM+ +F T+Q+ +D+++CLP
Sbjct: 1 MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPS 60
Query: 61 PA---------------------------QNHSSLSNVSQAVASTTPLPP-----PKPSP 88
P Q+ + +++S ++ TP P P+
Sbjct: 61 PVNSKAHTPPGNAEVTTNIPKMEAATNQDQDGRTTNDISFGTSAVTPDIPLRATYPRTDF 120
Query: 89 ANPITVEMK------GLKTDLDLQQYSFINQMCYERALHWYAKYFPYLVLIHTLVFMLCS 142
A P K G KT+LD QQY FINQMCY AL WY+KYFPYL LIHT++ M+ S
Sbjct: 121 ALPNQEAKKEKKDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSS 180
Query: 143 NFWFKFPGSSSKIEHFISILGKCFDSPWTTRALSEVSGEDSEEKDNRKNNMNR--SNTIQ 200
NFWFK+P + SK+EHF+SILGKCF+SPWTT+ALSE + EDSEE R +
Sbjct: 181 NFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVST 240
Query: 201 SGPEGS------LVNSQSLKSIPEKFVVDKSTAGALDKKEGEQAKALFEKVKKFRLHVEE 254
S EGS ++N K EK V++ + LDKK+GEQAKALFEKV+KFR HVE+
Sbjct: 241 SSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVED 300
Query: 255 GDILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVDCNVDIQDMTGYKNFSCNHTMAH 314
D++Y +YV QTV+K KF+ I+ Y + V+ + F C ++ + GY+ F C H MA+
Sbjct: 301 SDLIYKLYVVQTVIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMAY 360
Query: 315 LFSKLSFCYLCFVSIYGLTCLYTLYWLFYRSLREYSFEYVRQETGIDDIPDVKNDFAFML 374
+ KL Y+ + +YG CLYTL+WLF L+EYSFE VR+E+ DIPDVKNDFAF+L
Sbjct: 361 MLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLL 420
Query: 375 HMIDQYDPLYSKRFAVFLSEVSENKLKQLNLNNEWTPDKLRQKLQTNAHNRLELPLIMLS 434
HM+DQYD LYSKRF VFLSEVSENKL++++LN+EWT +KLRQ + NA ++ EL L MLS
Sbjct: 421 HMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLS 480
Query: 435 GLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKENLK 494
G+PD VF++T+L LKLE+I IPA I+Q+ NLQEL L C K+ A SFL+++L+
Sbjct: 481 GVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLR 540
Query: 495 VLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRDLKSLKILSIKSNVS 554
L VKF D+ E+P W+Y L+NL ELYL+G+L+ + ++ + LESLR+L+ LKIL +KSN++
Sbjct: 541 CLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLT 600
Query: 555 KIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSLLSL 614
K+P + DV+ HL K+ IHNDGTKL++LN+LKKM N+ ELEL +C+LERIPHA+FSL +L
Sbjct: 601 KVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNL 660
Query: 615 QELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEV 674
QELDLK NN+++IEEI+SFQHL++LT LKLWHN I IP I + +LE L FS+NK+E
Sbjct: 661 QELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLES 720
Query: 675 LPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTL 734
LP +F K+R LD+SYN+I IP EIG+LQ+LQ+ IT NKV+ LP +L+ C KL+TL
Sbjct: 721 LPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTL 780
Query: 735 KIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALKRAGLVVEDALFETLPS 794
+G+N ++ L K+G L L+ L++KGN + LP +LG CR LK++GLVVED LF+TLP
Sbjct: 781 NLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPL 840
Query: 795 DVREQMKTE 803
+V+E + +
Sbjct: 841 EVKEALNQD 849
>gi|197333692 leucine rich repeat containing 8 family, member B
[Homo sapiens]
Length = 803
Score = 831 bits (2147), Expect = 0.0
Identities = 407/810 (50%), Positives = 584/810 (72%), Gaps = 20/810 (2%)
Query: 1 MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIIC-LPKRV 59
MI +TE + ++ Q ++ +LKPWWDVF Y+++ ML++ V LQ+ Q +++C LP +V
Sbjct: 1 MITLTELKCLADAQSSYHILKPWWDVFWYYITLIMLLVAVLAGALQLTQSRVLCCLPCKV 60
Query: 60 QPAQNHSSLS-NVSQAVASTTPLPPPKPSPANPITVEMKGLKTDLDLQQYSFINQMCYER 118
+ NH ++ ++ +A +T+ +P P+ + ++ ++ DL QQYS+I+ +CYE+
Sbjct: 61 E-FDNHCAVPWDILKASMNTSS------NPGTPLPLPLR-IQNDLHRQQYSYIDAVCYEK 112
Query: 119 ALHWYAKYFPYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFISILGKCFDSPWTTRALSEV 178
LHW+AK+FPYLVL+HTL+F CSNFW +P +SS++EHF++IL KCFDSPWTTRALSE
Sbjct: 113 QLHWFAKFFPYLVLLHTLIFAACSNFWLHYPSTSSRLEHFVAILHKCFDSPWTTRALSET 172
Query: 179 SGEDSEEKDNRKNNMNRSNTIQSGPEGSLVNSQSLKSIP------EKFVVDKSTAGALDK 232
E S R +++S + S S +S+P E ++ T+ LDK
Sbjct: 173 VAEQSV----RPLKLSKSKILLSSSGCSADIDSGKQSLPYPQPGLESAGIESPTSSVLDK 228
Query: 233 KEGEQAKALFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVD 292
KEGEQAKA+FEKVK+FR+HVE+ DI+Y +Y++Q ++KVI F++II Y ++ + +D
Sbjct: 229 KEGEQAKAIFEKVKRFRMHVEQKDIIYRVYLKQIIVKVILFVLIITYVPYFLTHITLEID 288
Query: 293 CNVDIQDMTGYKNFSCNHTMAHLFSKLSFCYLCFVSIYGLTCLYTLYWLFYRSLREYSFE 352
C+VD+Q TGYK + C +++A +F L+ Y+ V +YGLT Y+L+W+ SL++YSFE
Sbjct: 289 CSVDVQAFTGYKRYQCVYSLAEIFKVLASFYVILVILYGLTSSYSLWWMLRSSLKQYSFE 348
Query: 353 YVRQETGIDDIPDVKNDFAFMLHMIDQYDPLYSKRFAVFLSEVSENKLKQLNLNNEWTPD 412
+R+++ DIPDVKNDFAF+LH+ DQYDPLYSKRF++FLSEVSENKLKQ+NLNNEWT +
Sbjct: 349 ALREKSNYSDIPDVKNDFAFILHLADQYDPLYSKRFSIFLSEVSENKLKQINLNNEWTVE 408
Query: 413 KLRQKLQTNAHNRLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQEL 472
KL+ KL NA +++EL L ML+GLPD VFE+TE++ L LE+I V +P+ ++QL NL+EL
Sbjct: 409 KLKSKLVKNAQDKIELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKEL 468
Query: 473 SLHQCSVKIHSAALSFLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRN 532
++ S+ + AL+FL+ENLK+L +KF +M ++P W++ L+NL+ELYL G + +
Sbjct: 469 RVYHSSLVVDHPALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLST 528
Query: 533 VTLESLRDLKSLKILSIKSNVSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLT 592
+ LE +DLK+L+ L +KS++S+IPQ V D+ LQK+ + N+G+KLV+LNNLKKM NL
Sbjct: 529 MQLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLK 588
Query: 593 ELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYI 652
LEL+ CDLERIPH++FSL +L ELDL+ENNLK++EEI+SFQHL+ L+ LKLWHN+I YI
Sbjct: 589 SLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYI 648
Query: 653 PEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFS 712
P I L++LE+LS HN IE LP LFLC K+ YLDLSYN + FIP EI L +LQYF+
Sbjct: 649 PAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFA 708
Query: 713 ITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELG 772
+T N +E LPD L+ CKKL+ L +GKNSL LSP +G L L++L++ GN+ E LPPEL
Sbjct: 709 VTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELE 768
Query: 773 DCRALKRAGLVVEDALFETLPSDVREQMKT 802
C++LKR L+VE+ L TLP V E+++T
Sbjct: 769 GCQSLKRNCLIVEENLLNTLPLPVTERLQT 798
>gi|21245134 leucine rich repeat containing 8 family, member B [Homo
sapiens]
Length = 803
Score = 831 bits (2147), Expect = 0.0
Identities = 407/810 (50%), Positives = 584/810 (72%), Gaps = 20/810 (2%)
Query: 1 MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIIC-LPKRV 59
MI +TE + ++ Q ++ +LKPWWDVF Y+++ ML++ V LQ+ Q +++C LP +V
Sbjct: 1 MITLTELKCLADAQSSYHILKPWWDVFWYYITLIMLLVAVLAGALQLTQSRVLCCLPCKV 60
Query: 60 QPAQNHSSLS-NVSQAVASTTPLPPPKPSPANPITVEMKGLKTDLDLQQYSFINQMCYER 118
+ NH ++ ++ +A +T+ +P P+ + ++ ++ DL QQYS+I+ +CYE+
Sbjct: 61 E-FDNHCAVPWDILKASMNTSS------NPGTPLPLPLR-IQNDLHRQQYSYIDAVCYEK 112
Query: 119 ALHWYAKYFPYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFISILGKCFDSPWTTRALSEV 178
LHW+AK+FPYLVL+HTL+F CSNFW +P +SS++EHF++IL KCFDSPWTTRALSE
Sbjct: 113 QLHWFAKFFPYLVLLHTLIFAACSNFWLHYPSTSSRLEHFVAILHKCFDSPWTTRALSET 172
Query: 179 SGEDSEEKDNRKNNMNRSNTIQSGPEGSLVNSQSLKSIP------EKFVVDKSTAGALDK 232
E S R +++S + S S +S+P E ++ T+ LDK
Sbjct: 173 VAEQSV----RPLKLSKSKILLSSSGCSADIDSGKQSLPYPQPGLESAGIESPTSSVLDK 228
Query: 233 KEGEQAKALFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVD 292
KEGEQAKA+FEKVK+FR+HVE+ DI+Y +Y++Q ++KVI F++II Y ++ + +D
Sbjct: 229 KEGEQAKAIFEKVKRFRMHVEQKDIIYRVYLKQIIVKVILFVLIITYVPYFLTHITLEID 288
Query: 293 CNVDIQDMTGYKNFSCNHTMAHLFSKLSFCYLCFVSIYGLTCLYTLYWLFYRSLREYSFE 352
C+VD+Q TGYK + C +++A +F L+ Y+ V +YGLT Y+L+W+ SL++YSFE
Sbjct: 289 CSVDVQAFTGYKRYQCVYSLAEIFKVLASFYVILVILYGLTSSYSLWWMLRSSLKQYSFE 348
Query: 353 YVRQETGIDDIPDVKNDFAFMLHMIDQYDPLYSKRFAVFLSEVSENKLKQLNLNNEWTPD 412
+R+++ DIPDVKNDFAF+LH+ DQYDPLYSKRF++FLSEVSENKLKQ+NLNNEWT +
Sbjct: 349 ALREKSNYSDIPDVKNDFAFILHLADQYDPLYSKRFSIFLSEVSENKLKQINLNNEWTVE 408
Query: 413 KLRQKLQTNAHNRLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQEL 472
KL+ KL NA +++EL L ML+GLPD VFE+TE++ L LE+I V +P+ ++QL NL+EL
Sbjct: 409 KLKSKLVKNAQDKIELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKEL 468
Query: 473 SLHQCSVKIHSAALSFLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRN 532
++ S+ + AL+FL+ENLK+L +KF +M ++P W++ L+NL+ELYL G + +
Sbjct: 469 RVYHSSLVVDHPALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLST 528
Query: 533 VTLESLRDLKSLKILSIKSNVSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLT 592
+ LE +DLK+L+ L +KS++S+IPQ V D+ LQK+ + N+G+KLV+LNNLKKM NL
Sbjct: 529 MQLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLK 588
Query: 593 ELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYI 652
LEL+ CDLERIPH++FSL +L ELDL+ENNLK++EEI+SFQHL+ L+ LKLWHN+I YI
Sbjct: 589 SLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYI 648
Query: 653 PEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFS 712
P I L++LE+LS HN IE LP LFLC K+ YLDLSYN + FIP EI L +LQYF+
Sbjct: 649 PAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFA 708
Query: 713 ITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELG 772
+T N +E LPD L+ CKKL+ L +GKNSL LSP +G L L++L++ GN+ E LPPEL
Sbjct: 709 VTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELE 768
Query: 773 DCRALKRAGLVVEDALFETLPSDVREQMKT 802
C++LKR L+VE+ L TLP V E+++T
Sbjct: 769 GCQSLKRNCLIVEENLLNTLPLPVTERLQT 798
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 120 bits (300), Expect = 7e-27
Identities = 105/400 (26%), Positives = 191/400 (47%), Gaps = 41/400 (10%)
Query: 425 RLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSA 484
RL+L + LP ++ E+T+L L L K +PA + L NL L+L + S+
Sbjct: 104 RLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPD 163
Query: 485 ALSFLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLE-SLRDLKS 543
+L LK+ L++L ++ + +RE+P +Y L +L LYL +R T+E +++L
Sbjct: 164 SLDNLKK-LRMLDLRHNKLREIPSVVYRLDSLTTLYL------RFNRITTVEKDIKNLSK 216
Query: 544 LKILSIKSN-VSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLE 602
L +LSI+ N + ++P + ++ + + HN L + T +T L+L H +L
Sbjct: 217 LSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLP--KEIGNCTQITNLDLQHNELL 274
Query: 603 RIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHI------ 656
+P + +L SL L L+ N L +I S L L L +N+I+ +PE +
Sbjct: 275 DLPDTIGNLSSLSRLGLRYNRLSAIPR--SLAKCSALEELNLENNNISTLPESLLSSLVK 332
Query: 657 -------------------KKLTSLERLSFSHNKIEVLPSHLFLCNKI-RYLDLSYNDIR 696
+ +++ L+ HN+I +P +F K+ L++ N +
Sbjct: 333 LNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLT 392
Query: 697 FIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSY 756
+P + G S+ ++ N++ +P+++ L+ L + N L L +GNL L
Sbjct: 393 SLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRE 452
Query: 757 LDVKGNHFEILPPELGDCRALKRAGLVVEDALFETLPSDV 796
LD++ N E LP E+ + L++ LV+ + TLP +
Sbjct: 453 LDLEENKLESLPNEIAYLKDLQK--LVLTNNQLTTLPRGI 490
Score = 112 bits (279), Expect = 2e-24
Identities = 113/409 (27%), Positives = 194/409 (47%), Gaps = 51/409 (12%)
Query: 433 LSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKEN 492
L+ LPD++ + +L+ L L K IP+ + +LD+L L L + + L +
Sbjct: 158 LTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSK- 216
Query: 493 LKVLSVKFDDMRELPPWMYGLRNLEELYLV-GSLSH--------------DISRNVTLE- 536
L +LS++ + +++LP + L NL L + L H D+ N L+
Sbjct: 217 LSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDL 276
Query: 537 --SLRDLKSLKILSIKSN-VSKIPQAVVDVSSHLQKMCIHNDGTKLV---MLNNLKKMTN 590
++ +L SL L ++ N +S IP+++ S+ L+++ + N+ + +L++L K+ +
Sbjct: 277 PDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSA-LEELNLENNNISTLPESLLSSLVKLNS 335
Query: 591 LT---------------------ELELVHCDLERIPHAVFSLLS-LQELDLKENNLKSIE 628
LT L + H + +IP +FS L +L++K+N L S+
Sbjct: 336 LTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLP 395
Query: 629 EIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYL 688
+ F + L L N +T IPE + L SLE L S+N ++ LP L K+R L
Sbjct: 396 --LDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLREL 453
Query: 689 DLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKI 748
DL N + +P EI L+ LQ +T N++ +LP + L L +G+N L+ L +I
Sbjct: 454 DLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEI 513
Query: 749 GNLLFLSYLDVKGN-HFEILPPELGDCRALKRAGLVVEDALFETLPSDV 796
G L L L + N + LP EL C K + + +E+ LP +
Sbjct: 514 GTLENLEELYLNDNPNLHSLPFELALCS--KLSIMSIENCPLSHLPPQI 560
Score = 33.1 bits (74), Expect = 1.1
Identities = 31/116 (26%), Positives = 50/116 (43%), Gaps = 12/116 (10%)
Query: 394 EVSENKLKQLNLNNEWTPDKLRQKLQTNAHNRLELPLIMLSGLPDTVFEITELQSLKLEI 453
++ ENKL+ L + D + L N L+ LP + +T L L L
Sbjct: 454 DLEENKLESLPNEIAYLKDLQKLVLTNN----------QLTTLPRGIGHLTNLTHLGLGE 503
Query: 454 IKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSF-LKENLKVLSVKFDDMRELPP 508
+P I L+NL+EL L+ + +HS L L ++S++ + LPP
Sbjct: 504 NLLTHLPEEIGTLENLEELYLND-NPNLHSLPFELALCSKLSIMSIENCPLSHLPP 558
Score = 30.0 bits (66), Expect = 8.9
Identities = 39/138 (28%), Positives = 58/138 (42%), Gaps = 31/138 (22%)
Query: 426 LELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAA 485
L+L L LP+ + + +LQ L L + +P I L NL L
Sbjct: 453 LDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLG------------ 500
Query: 486 LSFLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLS-HDISRNVTLESLRDLKSL 544
L ENL + LP + L NLEELYL + + H + + L S L
Sbjct: 501 ---LGENL---------LTHLPEEIGTLENLEELYLNDNPNLHSLPFELALCS-----KL 543
Query: 545 KILSIKS-NVSKIPQAVV 561
I+SI++ +S +P +V
Sbjct: 544 SIMSIENCPLSHLPPQIV 561
>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
Length = 1537
Score = 118 bits (296), Expect = 2e-26
Identities = 90/308 (29%), Positives = 149/308 (48%), Gaps = 41/308 (13%)
Query: 493 LKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRDLKSLKILSI--- 549
L+ LS+ +D+ LP + L NL+EL DIS+N E ++K K L+I
Sbjct: 71 LRKLSIPDNDLSNLPTTIASLVNLKEL--------DISKNGVQEFPENIKCCKCLTIIEA 122
Query: 550 -KSNVSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAV 608
+ +SK+P + ++ NLT+L L LE +P
Sbjct: 123 SVNPISKLP-------------------------DGFTQLLNLTQLYLNDAFLEFLPANF 157
Query: 609 FSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFS 668
L+ L+ L+L+EN+LK++ + S L +L L L +N +PE + ++ +L L
Sbjct: 158 GRLVKLRILELRENHLKTLPK--SMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMD 215
Query: 669 HNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFC 728
+N ++VLP + + YLD+S N I + +I ++L+ ++ N ++ LPD +
Sbjct: 216 NNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLL 275
Query: 729 KKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALKRAGLVVEDAL 788
KKL TLK+ N L++L IGNL L D N E LP +G +L+ L V++
Sbjct: 276 KKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRT--LAVDENF 333
Query: 789 FETLPSDV 796
LP ++
Sbjct: 334 LPELPREI 341
Score = 104 bits (260), Expect = 3e-22
Identities = 96/363 (26%), Positives = 172/363 (47%), Gaps = 24/363 (6%)
Query: 426 LELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAA 485
L L + LP +F L+ L + +P TIA L NL+EL + + V+
Sbjct: 51 LYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPEN 110
Query: 486 LSFLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGS----LSHDISRNVTL------ 535
+ K L ++ + + +LP L NL +LYL + L + R V L
Sbjct: 111 IKCCK-CLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELR 169
Query: 536 --------ESLRDLKSLKILSIKSN-VSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLK 586
+S+ L L+ L + +N ++P+ V+D +L+++ + N+ + V+ ++
Sbjct: 170 ENHLKTLPKSMHKLAQLERLDLGNNEFGELPE-VLDQIQNLRELWMDNNALQ-VLPGSIG 227
Query: 587 KMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWH 646
K+ L L++ +E + + +L++L L N L+ + + + L+KLT LK+
Sbjct: 228 KLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGL--LKKLTTLKVDD 285
Query: 647 NSITYIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQ 706
N +T +P I L+ LE S N++E LPS + + +R L + N + +P EIG +
Sbjct: 286 NQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCK 345
Query: 707 SLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEI 766
++ S+ NK+E LP+E+ +KL+ L + N L L L L+ L + N +
Sbjct: 346 NVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKA 405
Query: 767 LPP 769
L P
Sbjct: 406 LIP 408
Score = 78.6 bits (192), Expect = 2e-14
Identities = 59/253 (23%), Positives = 112/253 (44%), Gaps = 51/253 (20%)
Query: 591 LTELELVHCDLERIPHAVF----------------------------------------- 609
++ L+ HC L+++P VF
Sbjct: 24 ISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSN 83
Query: 610 ------SLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLE 663
SL++L+ELD+ +N ++ E + + + LT+++ N I+ +P+ +L +L
Sbjct: 84 LPTTIASLVNLKELDISKNGVQEFPE--NIKCCKCLTIIEASVNPISKLPDGFTQLLNLT 141
Query: 664 RLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPD 723
+L + +E LP++ K+R L+L N ++ +P + L L+ + N+ LP+
Sbjct: 142 QLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPE 201
Query: 724 ELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALKRAGLV 783
L + L+ L + N+L VL IG L L YLD+ N E + ++ C AL+ L+
Sbjct: 202 VLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALE--DLL 259
Query: 784 VEDALFETLPSDV 796
+ + + LP +
Sbjct: 260 LSSNMLQQLPDSI 272
Score = 71.2 bits (173), Expect = 3e-12
Identities = 49/166 (29%), Positives = 79/166 (47%), Gaps = 3/166 (1%)
Query: 639 LTVLKLWHNSITYIPEHIKKLT-SLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRF 697
++VL H S+ +P+ + +LE L N+IE LP LF C +R L + ND+
Sbjct: 24 ISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSN 83
Query: 698 IPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYL 757
+P I L +L+ I+ N V+ P+ + CK L ++ N +S L LL L+ L
Sbjct: 84 LPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQL 143
Query: 758 DVKGNHFEILPPELGDCRALKRAGLVVEDALFETLPSDVREQMKTE 803
+ E LP G R +K L + + +TLP + + + E
Sbjct: 144 YLNDAFLEFLPANFG--RLVKLRILELRENHLKTLPKSMHKLAQLE 187
>gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
Length = 860
Score = 115 bits (289), Expect = 1e-25
Identities = 105/389 (26%), Positives = 186/389 (47%), Gaps = 38/389 (9%)
Query: 433 LSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKEN 492
LS LP + + L+ L + IP I+QL N+++L + ++ + L L N
Sbjct: 200 LSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLG-N 258
Query: 493 LKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTL-ESLRDLKSLKILSIKS 551
L++LS+ + +R +P + L+ L L L + ++ T ++L L L L +
Sbjct: 259 LEILSLGKNKLRHIPDTLPSLKTLRVLNL------EYNQLTTFPKALCFLPKLISLDLTG 312
Query: 552 N-VSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFS 610
N +S +P+ + ++ + + HN T L + + ++ + EL+L LE I H + +
Sbjct: 313 NLISSLPKEIRELKNLETLLMDHNKLTFLAV--EIFQLLKIKELQLADNKLEVISHKIEN 370
Query: 611 LLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERL----- 665
L+ L L +N LK+I E +S + L L L N +T +P++I KL +L +L
Sbjct: 371 FRELRILILDKNLLKNIPEKISCCAM--LECLSLSDNKLTELPKYIHKLNNLRKLHVNRN 428
Query: 666 ------------------SFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQS 707
FS N I +P + C KI ++LSYN I + P + L S
Sbjct: 429 NMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDS 488
Query: 708 LQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEIL 767
L Y S+ N + +P ++ F K+L L++ +N L + S +L+ L YLD+ N + +
Sbjct: 489 LYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKI 548
Query: 768 PPELGDCRALKRAGLVVEDALFETLPSDV 796
P + + +L L++ FET P ++
Sbjct: 549 PASISNMISLH--VLILCCNKFETFPREL 575
Score = 97.4 bits (241), Expect = 5e-20
Identities = 93/375 (24%), Positives = 161/375 (42%), Gaps = 36/375 (9%)
Query: 433 LSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKEN 492
L +PDT+ + L+ L LE + P + L L L L + + LK N
Sbjct: 269 LRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELK-N 327
Query: 493 LKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRDLKSLKILSIKSN 552
L+ L + + + L ++ L ++EL L + IS + + + L+IL + N
Sbjct: 328 LETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKI-----ENFRELRILILDKN 382
Query: 553 VSK-IPQAVVDVSSHLQKMCIHNDGTKLVMLNN-LKKMTNLTELELVHCDLERIPHAVFS 610
+ K IP+ + S C+ KL L + K+ NL +L + ++ +I +
Sbjct: 383 LLKNIPEKI---SCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISH 439
Query: 611 LLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLS---- 666
L ++ L+ N + + + ++ +K+ ++L +N I Y P + L SL LS
Sbjct: 440 LNNICSLEFSGNIITDVP--IEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGN 497
Query: 667 -------------------FSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQS 707
S NK+ + H ++YLDL N I+ IP I + S
Sbjct: 498 YISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMIS 557
Query: 708 LQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEIL 767
L + CNK E+ P EL + L+ L + +N L +S I NL + L+ N F
Sbjct: 558 LHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHF 617
Query: 768 PPELGDCRALKRAGL 782
P EL ++L++ +
Sbjct: 618 PIELCQLQSLEQLNI 632
Score = 90.1 bits (222), Expect = 7e-18
Identities = 106/441 (24%), Positives = 186/441 (42%), Gaps = 98/441 (22%)
Query: 426 LELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAA 485
L+L ++S LP + E+ L++L ++ K + I QL ++EL L +++ S
Sbjct: 308 LDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHK 367
Query: 486 LSFLKE----------------------NLKVLSVKFDDMRELPPWMYGLRNLEELY--- 520
+ +E L+ LS+ + + ELP +++ L NL +L+
Sbjct: 368 IENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNR 427
Query: 521 -----LVGSLSH-----------DISRNVTLE----------------------SLRDLK 542
+ +SH +I +V +E L L
Sbjct: 428 NNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALD 487
Query: 543 SLKILSIKSN-VSKIPQAVVDVSSHLQKMCIHNDGTKLVMLN-NLKKMTNLTELELVHCD 600
SL LS+ N +S+IP VD+S Q + + KL++ + + + NL L+L
Sbjct: 488 SLYYLSVNGNYISEIP---VDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQ 544
Query: 601 LERIPHAVFSLLSL-----------------------QELDLKENNLKSIEEIVSFQHLR 637
+++IP ++ +++SL Q LDL EN L+ I + +L+
Sbjct: 545 IKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDIC--NLK 602
Query: 638 KLTVLKLWHNSITYIPEHIKKLTSLERLSFSH---NKIEVLPSHLFLCNKIRYLDLSYND 694
+ L N + P + +L SLE+L+ S K+ LP L +++ LD+S N
Sbjct: 603 GIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNA 662
Query: 695 IRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFL 754
IR IP IG L++L N++ LP L L+ L + N+L+ L I N+ L
Sbjct: 663 IREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSL 722
Query: 755 SYLDVKGNHFEILPPELGDCR 775
++ N +L P + C+
Sbjct: 723 KEINFDDN--PLLRPPVEICK 741
Score = 80.9 bits (198), Expect = 4e-15
Identities = 84/358 (23%), Positives = 155/358 (43%), Gaps = 38/358 (10%)
Query: 395 VSENKLKQL-----NLNNEWTPDKLRQKLQTNAHNRLELPLIMLSGLPDTVFEITELQSL 449
+S+NKL +L LNN +KL N +N +++ D + + + SL
Sbjct: 402 LSDNKLTELPKYIHKLNN-------LRKLHVNRNNMVKIT--------DCISHLNNICSL 446
Query: 450 KLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKENLKVLSVKFDDMRELPPW 509
+ +P I + ++ L + L L ++L LSV + + E+P
Sbjct: 447 EFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCAL-DSLYYLSVNGNYISEIPVD 505
Query: 510 MYGLRNLEELYLVGSLSHDISRNVTL---ESLRDLKSLKILSI-KSNVSKIPQAVVD-VS 564
+ + L L ++S N L E L +LK L + K+ + KIP ++ + +S
Sbjct: 506 ISFSKQLLHL--------ELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMIS 557
Query: 565 SHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNL 624
H+ +C + T L + NL L+L L++I + +L +Q+L+ N
Sbjct: 558 LHVLILCCNKFET---FPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQF 614
Query: 625 KSIE-EIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCN 683
E+ Q L +L + ++ +T +P + +T L+ L S+N I +P ++
Sbjct: 615 IHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELR 674
Query: 684 KIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSL 741
+ L N I ++PP + L LQ +++ N + +LP +Y LK + N L
Sbjct: 675 NLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPL 732
Score = 73.2 bits (178), Expect = 9e-13
Identities = 51/178 (28%), Positives = 85/178 (47%), Gaps = 1/178 (0%)
Query: 601 LERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLT 660
L+ P + + ++ L L +N +K+ + S L L +L L N ++ +P I+ L
Sbjct: 153 LQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGD-LLGLEILSLQENGLSSLPSEIQLLH 211
Query: 661 SLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVES 720
+L L+ SHN I +P + IR L N I P ++ L +L+ S+ NK+
Sbjct: 212 NLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRH 271
Query: 721 LPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALK 778
+PD L K L+ L + N L+ + L L LD+ GN LP E+ + + L+
Sbjct: 272 IPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLE 329
>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
Length = 1302
Score = 112 bits (280), Expect = 1e-24
Identities = 95/366 (25%), Positives = 170/366 (46%), Gaps = 30/366 (8%)
Query: 426 LELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAA 485
L L + LP +F L L L +PA+IA L NL+EL + + ++
Sbjct: 51 LYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPEN 110
Query: 486 LSFLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRDLKSLK 545
+ K L ++ + + +LP L NL +LYL + + N L L+
Sbjct: 111 IKNCKV-LTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPAN-----FGRLTKLQ 164
Query: 546 ILSIKSNVSKIPQAVVDVSSHLQKMCI-HNDGTKLVMLNNLKKMTNLTELELVHCDLERI 604
IL ++ N K+ ++ + L+++ + N+ T++ + L++++ L E + L I
Sbjct: 165 ILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEV--LEQLSGLKEFWMDANRLTFI 222
Query: 605 PHAVFSLLSLQELDLKENNLKSIEEIVS---------------------FQHLRKLTVLK 643
P + SL L LD+ +NN++ +EE +S L+ +T LK
Sbjct: 223 PGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLK 282
Query: 644 LWHNSITYIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIG 703
+ N + Y+P+ I L S+E L S N++E LPS + +R +N ++ +PPEIG
Sbjct: 283 IDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIG 342
Query: 704 VLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNH 763
+++ + NK+E+LP+E+ +KLK + + N L L L L+ + + N
Sbjct: 343 SWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQ 402
Query: 764 FEILPP 769
+ L P
Sbjct: 403 SKPLIP 408
Score = 111 bits (278), Expect = 2e-24
Identities = 82/292 (28%), Positives = 139/292 (47%), Gaps = 39/292 (13%)
Query: 491 ENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRDLKSLKILSIK 550
++L LS+ +D+ LP + L NL EL D+S+N E ++K+ K+L+I
Sbjct: 69 QSLHKLSLPDNDLTTLPASIANLINLREL--------DVSKNGIQEFPENIKNCKVLTIV 120
Query: 551 ----SNVSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPH 606
+ +SK+P + ++ NLT+L L LE +P
Sbjct: 121 EASVNPISKLP-------------------------DGFSQLLNLTQLYLNDAFLEFLPA 155
Query: 607 AVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLS 666
L LQ L+L+EN LK + + ++ L +L L L N T +PE +++L+ L+
Sbjct: 156 NFGRLTKLQILELRENQLKMLPKTMN--RLTQLERLDLGSNEFTEVPEVLEQLSGLKEFW 213
Query: 667 FSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELY 726
N++ +P + ++ YLD+S N+I + I ++LQ ++ N ++ LP+ +
Sbjct: 214 MDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIG 273
Query: 727 FCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALK 778
K + TLKI +N L L IG L+ + LD N E LP +G L+
Sbjct: 274 SLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLR 325
Score = 66.2 bits (160), Expect = 1e-10
Identities = 47/166 (28%), Positives = 74/166 (44%), Gaps = 3/166 (1%)
Query: 639 LTVLKLWHNSITYIPEHIKKLT-SLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRF 697
+T L H S+ +P+ I +LE L N+IE LP LF C + L L ND+
Sbjct: 24 VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83
Query: 698 IPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYL 757
+P I L +L+ ++ N ++ P+ + CK L ++ N +S L LL L+ L
Sbjct: 84 LPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQL 143
Query: 758 DVKGNHFEILPPELGDCRALKRAGLVVEDALFETLPSDVREQMKTE 803
+ E LP G R K L + + + LP + + E
Sbjct: 144 YLNDAFLEFLPANFG--RLTKLQILELRENQLKMLPKTMNRLTQLE 187
Score = 63.5 bits (153), Expect = 7e-10
Identities = 50/192 (26%), Positives = 79/192 (41%), Gaps = 24/192 (12%)
Query: 591 LTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSIT 650
+T L+ HC LE++P +F+ K++EE L L N I
Sbjct: 24 VTTLDYSHCSLEQVPKEIFTFE------------KTLEE------------LYLDANQIE 59
Query: 651 YIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQY 710
+P+ + SL +LS N + LP+ + +R LD+S N I+ P I + L
Sbjct: 60 ELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTI 119
Query: 711 FSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPE 770
+ N + LPD L L + L L G L L L+++ N ++LP
Sbjct: 120 VEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKT 179
Query: 771 LGDCRALKRAGL 782
+ L+R L
Sbjct: 180 MNRLTQLERLDL 191
Score = 52.8 bits (125), Expect = 1e-06
Identities = 61/282 (21%), Positives = 126/282 (44%), Gaps = 42/282 (14%)
Query: 394 EVSENKLKQLNLNNEWTPDKLRQKLQTNAHNRLELPLIMLSGLPDTVFEITELQSLKLEI 453
E+ EN+LK L P + + Q RL+L + +P+ + +++ L+ ++
Sbjct: 167 ELRENQLKML-------PKTMNRLTQLE---RLDLGSNEFTEVPEVLEQLSGLKEFWMDA 216
Query: 454 IKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKENLKVLSVKFDDMRELPPWMYGL 513
+ IP I L L L + + ++++ +S ENL+ L + + +++LP
Sbjct: 217 NRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTC-ENLQDLLLSSNSLQQLPE----- 270
Query: 514 RNLEELYLVGSLSHDISRNVTLESLRDLKSLKILSIKSNVSKIPQAVVDVSSHLQKMCIH 573
T+ SL+++ +LKI ++ + +P ++ + S + C
Sbjct: 271 --------------------TIGSLKNITTLKI--DENQLMYLPDSIGGLISVEELDCSF 308
Query: 574 NDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSF 633
N+ L +++ ++TNL H L+++P + S ++ L L N L+++ E
Sbjct: 309 NEVEALP--SSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPE--EM 364
Query: 634 QHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVL 675
++KL V+ L N + +P KL L + S N+ + L
Sbjct: 365 GDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPL 406
>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
Length = 1371
Score = 112 bits (280), Expect = 1e-24
Identities = 95/366 (25%), Positives = 170/366 (46%), Gaps = 30/366 (8%)
Query: 426 LELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAA 485
L L + LP +F L L L +PA+IA L NL+EL + + ++
Sbjct: 51 LYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPEN 110
Query: 486 LSFLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRDLKSLK 545
+ K L ++ + + +LP L NL +LYL + + N L L+
Sbjct: 111 IKNCKV-LTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPAN-----FGRLTKLQ 164
Query: 546 ILSIKSNVSKIPQAVVDVSSHLQKMCI-HNDGTKLVMLNNLKKMTNLTELELVHCDLERI 604
IL ++ N K+ ++ + L+++ + N+ T++ + L++++ L E + L I
Sbjct: 165 ILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEV--LEQLSGLKEFWMDANRLTFI 222
Query: 605 PHAVFSLLSLQELDLKENNLKSIEEIVS---------------------FQHLRKLTVLK 643
P + SL L LD+ +NN++ +EE +S L+ +T LK
Sbjct: 223 PGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLK 282
Query: 644 LWHNSITYIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIG 703
+ N + Y+P+ I L S+E L S N++E LPS + +R +N ++ +PPEIG
Sbjct: 283 IDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIG 342
Query: 704 VLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNH 763
+++ + NK+E+LP+E+ +KLK + + N L L L L+ + + N
Sbjct: 343 SWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQ 402
Query: 764 FEILPP 769
+ L P
Sbjct: 403 SKPLIP 408
Score = 111 bits (278), Expect = 2e-24
Identities = 82/292 (28%), Positives = 139/292 (47%), Gaps = 39/292 (13%)
Query: 491 ENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRDLKSLKILSIK 550
++L LS+ +D+ LP + L NL EL D+S+N E ++K+ K+L+I
Sbjct: 69 QSLHKLSLPDNDLTTLPASIANLINLREL--------DVSKNGIQEFPENIKNCKVLTIV 120
Query: 551 ----SNVSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPH 606
+ +SK+P + ++ NLT+L L LE +P
Sbjct: 121 EASVNPISKLP-------------------------DGFSQLLNLTQLYLNDAFLEFLPA 155
Query: 607 AVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLS 666
L LQ L+L+EN LK + + ++ L +L L L N T +PE +++L+ L+
Sbjct: 156 NFGRLTKLQILELRENQLKMLPKTMN--RLTQLERLDLGSNEFTEVPEVLEQLSGLKEFW 213
Query: 667 FSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELY 726
N++ +P + ++ YLD+S N+I + I ++LQ ++ N ++ LP+ +
Sbjct: 214 MDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIG 273
Query: 727 FCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALK 778
K + TLKI +N L L IG L+ + LD N E LP +G L+
Sbjct: 274 SLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLR 325
Score = 66.2 bits (160), Expect = 1e-10
Identities = 47/166 (28%), Positives = 74/166 (44%), Gaps = 3/166 (1%)
Query: 639 LTVLKLWHNSITYIPEHIKKLT-SLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRF 697
+T L H S+ +P+ I +LE L N+IE LP LF C + L L ND+
Sbjct: 24 VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83
Query: 698 IPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYL 757
+P I L +L+ ++ N ++ P+ + CK L ++ N +S L LL L+ L
Sbjct: 84 LPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQL 143
Query: 758 DVKGNHFEILPPELGDCRALKRAGLVVEDALFETLPSDVREQMKTE 803
+ E LP G R K L + + + LP + + E
Sbjct: 144 YLNDAFLEFLPANFG--RLTKLQILELRENQLKMLPKTMNRLTQLE 187
Score = 63.5 bits (153), Expect = 7e-10
Identities = 50/192 (26%), Positives = 79/192 (41%), Gaps = 24/192 (12%)
Query: 591 LTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSIT 650
+T L+ HC LE++P +F+ K++EE L L N I
Sbjct: 24 VTTLDYSHCSLEQVPKEIFTFE------------KTLEE------------LYLDANQIE 59
Query: 651 YIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQY 710
+P+ + SL +LS N + LP+ + +R LD+S N I+ P I + L
Sbjct: 60 ELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTI 119
Query: 711 FSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPE 770
+ N + LPD L L + L L G L L L+++ N ++LP
Sbjct: 120 VEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKT 179
Query: 771 LGDCRALKRAGL 782
+ L+R L
Sbjct: 180 MNRLTQLERLDL 191
Score = 52.8 bits (125), Expect = 1e-06
Identities = 61/282 (21%), Positives = 126/282 (44%), Gaps = 42/282 (14%)
Query: 394 EVSENKLKQLNLNNEWTPDKLRQKLQTNAHNRLELPLIMLSGLPDTVFEITELQSLKLEI 453
E+ EN+LK L P + + Q RL+L + +P+ + +++ L+ ++
Sbjct: 167 ELRENQLKML-------PKTMNRLTQLE---RLDLGSNEFTEVPEVLEQLSGLKEFWMDA 216
Query: 454 IKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKENLKVLSVKFDDMRELPPWMYGL 513
+ IP I L L L + + ++++ +S ENL+ L + + +++LP
Sbjct: 217 NRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTC-ENLQDLLLSSNSLQQLPE----- 270
Query: 514 RNLEELYLVGSLSHDISRNVTLESLRDLKSLKILSIKSNVSKIPQAVVDVSSHLQKMCIH 573
T+ SL+++ +LKI ++ + +P ++ + S + C
Sbjct: 271 --------------------TIGSLKNITTLKI--DENQLMYLPDSIGGLISVEELDCSF 308
Query: 574 NDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSF 633
N+ L +++ ++TNL H L+++P + S ++ L L N L+++ E
Sbjct: 309 NEVEALP--SSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPE--EM 364
Query: 634 QHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVL 675
++KL V+ L N + +P KL L + S N+ + L
Sbjct: 365 GDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPL 406
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 110 bits (274), Expect = 7e-24
Identities = 91/309 (29%), Positives = 154/309 (49%), Gaps = 18/309 (5%)
Query: 492 NLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRN---VTLESLRDLKSLKILS 548
NL+ L + ++++ LPP + L EL D+SRN ES++ K+L+I
Sbjct: 60 NLRKLGLSDNEIQRLPPEVANFMQLVEL--------DVSRNDIPEIPESIKFCKALEIAD 111
Query: 549 IKSN-VSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHA 607
N +S++P + S L + + ND + + ++ + NL LEL L+ +P +
Sbjct: 112 FSGNPLSRLPDGFTQLRS-LAHLAL-NDVSLQALPGDVGNLANLVTLELRENLLKSLPAS 169
Query: 608 VFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSF 667
+ L+ L++LDL N+L+ + + + L L L L N ++ +P + L L L
Sbjct: 170 LSFLVKLEQLDLGGNDLEVLPDTLGA--LPNLRELWLDRNQLSALPPELGNLRRLVCLDV 227
Query: 668 SHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYF 727
S N++E LP+ L + L LS N +R +P IG L+ L + N++ + + +
Sbjct: 228 SENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGD 287
Query: 728 CKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALKRAGLVVEDA 787
C+ L L + +N L L +G L L+ L+V NH E LPPE+G C AL + L + D
Sbjct: 288 CENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVAL--SVLSLRDN 345
Query: 788 LFETLPSDV 796
LP ++
Sbjct: 346 RLAVLPPEL 354
Score = 99.4 bits (246), Expect = 1e-20
Identities = 88/336 (26%), Positives = 151/336 (44%), Gaps = 9/336 (2%)
Query: 433 LSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKEN 492
L LP F + L+ L L + +P +A L EL + + + ++ F K
Sbjct: 48 LRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKA- 106
Query: 493 LKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRDLKSLKILSIKSN 552
L++ + + LP LR+L L L +D+S + +L +L L ++ N
Sbjct: 107 LEIADFSGNPLSRLPDGFTQLRSLAHLAL-----NDVSLQALPGDVGNLANLVTLELREN 161
Query: 553 VSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSLL 612
+ K A + L+++ + + + V+ + L + NL EL L L +P + +L
Sbjct: 162 LLKSLPASLSFLVKLEQLDLGGNDLE-VLPDTLGALPNLRELWLDRNQLSALPPELGNLR 220
Query: 613 SLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKI 672
L LD+ EN L+ + L LT L L N + +P+ I +L L L N++
Sbjct: 221 RLVCLDVSENRLEELP--AELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRL 278
Query: 673 EVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLK 732
+ + C + L L+ N + +P +G L L ++ N +E+LP E+ C L
Sbjct: 279 CEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALS 338
Query: 733 TLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILP 768
L + N L+VL P++ + L LDV GN + LP
Sbjct: 339 VLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLP 374
Score = 94.4 bits (233), Expect = 4e-19
Identities = 70/208 (33%), Positives = 106/208 (50%), Gaps = 6/208 (2%)
Query: 590 NLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIE-EIVSFQHLRKLTVLKLWHNS 648
+L EL L L +P F LL+L++L L +N ++ + E+ +F L +L V + N
Sbjct: 37 SLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSR---ND 93
Query: 649 ITYIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSL 708
I IPE IK +LE FS N + LP + +L L+ ++ +P ++G L +L
Sbjct: 94 IPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANL 153
Query: 709 QYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILP 768
+ N ++SLP L F KL+ L +G N L VL +G L L L + N LP
Sbjct: 154 VTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALP 213
Query: 769 PELGDCRALKRAGLVVEDALFETLPSDV 796
PELG+ R L L V + E LP+++
Sbjct: 214 PELGNLRRL--VCLDVSENRLEELPAEL 239
Score = 67.0 bits (162), Expect = 7e-11
Identities = 51/180 (28%), Positives = 89/180 (49%), Gaps = 3/180 (1%)
Query: 614 LQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIE 673
++ +D + +L+++ E + +++ R L L L N + +P+ +L +L +L S N+I+
Sbjct: 14 VESVDKRHCSLQAVPEEI-YRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQ 72
Query: 674 VLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKT 733
LP + ++ LD+S NDI IP I ++L+ + N + LPD + L
Sbjct: 73 RLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAH 132
Query: 734 LKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALKRAGLVVEDALFETLP 793
L + SL L +GNL L L+++ N + LP L L++ L D E LP
Sbjct: 133 LALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGND--LEVLP 190
Score = 62.0 bits (149), Expect = 2e-09
Identities = 65/249 (26%), Positives = 118/249 (47%), Gaps = 12/249 (4%)
Query: 426 LELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAA 485
LEL +L LP ++ + +L+ L L ++P T+ L NL+EL L + +
Sbjct: 156 LELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPE 215
Query: 486 LSFLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRDLKSLK 545
L L+ L L V + + ELP + GL L +L LS ++ R + + + LK L
Sbjct: 216 LGNLR-RLVCLDVSENRLEELPAELGGLVLLTDLL----LSQNLLRRLP-DGIGQLKQLS 269
Query: 546 ILSIKSN-VSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERI 604
IL + N + ++ +A+ D + + + N + + +L K+T LT L + LE +
Sbjct: 270 ILKVDQNRLCEVTEAIGDCENLSELILTEN--LLMALPRSLGKLTKLTNLNVDRNHLEAL 327
Query: 605 PHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLER 664
P + ++L L L++N L + H +L VL + N + +P + L +L+
Sbjct: 328 PPEIGGCVALSVLSLRDNRLAVLPP--ELAHTTELHVLDVAGNRLQSLPFALTHL-NLKA 384
Query: 665 LSFSHNKIE 673
L + N+ +
Sbjct: 385 LWLAENQAQ 393
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 110 bits (274), Expect = 7e-24
Identities = 91/309 (29%), Positives = 154/309 (49%), Gaps = 18/309 (5%)
Query: 492 NLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRN---VTLESLRDLKSLKILS 548
NL+ L + ++++ LPP + L EL D+SRN ES++ K+L+I
Sbjct: 60 NLRKLGLSDNEIQRLPPEVANFMQLVEL--------DVSRNDIPEIPESIKFCKALEIAD 111
Query: 549 IKSN-VSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHA 607
N +S++P + S L + + ND + + ++ + NL LEL L+ +P +
Sbjct: 112 FSGNPLSRLPDGFTQLRS-LAHLAL-NDVSLQALPGDVGNLANLVTLELRENLLKSLPAS 169
Query: 608 VFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSF 667
+ L+ L++LDL N+L+ + + + L L L L N ++ +P + L L L
Sbjct: 170 LSFLVKLEQLDLGGNDLEVLPDTLGA--LPNLRELWLDRNQLSALPPELGNLRRLVCLDV 227
Query: 668 SHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYF 727
S N++E LP+ L + L LS N +R +P IG L+ L + N++ + + +
Sbjct: 228 SENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGD 287
Query: 728 CKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALKRAGLVVEDA 787
C+ L L + +N L L +G L L+ L+V NH E LPPE+G C AL + L + D
Sbjct: 288 CENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVAL--SVLSLRDN 345
Query: 788 LFETLPSDV 796
LP ++
Sbjct: 346 RLAVLPPEL 354
Score = 99.4 bits (246), Expect = 1e-20
Identities = 88/336 (26%), Positives = 151/336 (44%), Gaps = 9/336 (2%)
Query: 433 LSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKEN 492
L LP F + L+ L L + +P +A L EL + + + ++ F K
Sbjct: 48 LRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKA- 106
Query: 493 LKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRDLKSLKILSIKSN 552
L++ + + LP LR+L L L +D+S + +L +L L ++ N
Sbjct: 107 LEIADFSGNPLSRLPDGFTQLRSLAHLAL-----NDVSLQALPGDVGNLANLVTLELREN 161
Query: 553 VSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSLL 612
+ K A + L+++ + + + V+ + L + NL EL L L +P + +L
Sbjct: 162 LLKSLPASLSFLVKLEQLDLGGNDLE-VLPDTLGALPNLRELWLDRNQLSALPPELGNLR 220
Query: 613 SLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKI 672
L LD+ EN L+ + L LT L L N + +P+ I +L L L N++
Sbjct: 221 RLVCLDVSENRLEELP--AELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRL 278
Query: 673 EVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLK 732
+ + C + L L+ N + +P +G L L ++ N +E+LP E+ C L
Sbjct: 279 CEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALS 338
Query: 733 TLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILP 768
L + N L+VL P++ + L LDV GN + LP
Sbjct: 339 VLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLP 374
Score = 94.4 bits (233), Expect = 4e-19
Identities = 70/208 (33%), Positives = 106/208 (50%), Gaps = 6/208 (2%)
Query: 590 NLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIE-EIVSFQHLRKLTVLKLWHNS 648
+L EL L L +P F LL+L++L L +N ++ + E+ +F L +L V + N
Sbjct: 37 SLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSR---ND 93
Query: 649 ITYIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSL 708
I IPE IK +LE FS N + LP + +L L+ ++ +P ++G L +L
Sbjct: 94 IPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANL 153
Query: 709 QYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILP 768
+ N ++SLP L F KL+ L +G N L VL +G L L L + N LP
Sbjct: 154 VTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALP 213
Query: 769 PELGDCRALKRAGLVVEDALFETLPSDV 796
PELG+ R L L V + E LP+++
Sbjct: 214 PELGNLRRL--VCLDVSENRLEELPAEL 239
Score = 67.0 bits (162), Expect = 7e-11
Identities = 51/180 (28%), Positives = 89/180 (49%), Gaps = 3/180 (1%)
Query: 614 LQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIE 673
++ +D + +L+++ E + +++ R L L L N + +P+ +L +L +L S N+I+
Sbjct: 14 VESVDKRHCSLQAVPEEI-YRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQ 72
Query: 674 VLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKT 733
LP + ++ LD+S NDI IP I ++L+ + N + LPD + L
Sbjct: 73 RLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAH 132
Query: 734 LKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALKRAGLVVEDALFETLP 793
L + SL L +GNL L L+++ N + LP L L++ L D E LP
Sbjct: 133 LALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGND--LEVLP 190
Score = 62.0 bits (149), Expect = 2e-09
Identities = 65/249 (26%), Positives = 118/249 (47%), Gaps = 12/249 (4%)
Query: 426 LELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAA 485
LEL +L LP ++ + +L+ L L ++P T+ L NL+EL L + +
Sbjct: 156 LELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPE 215
Query: 486 LSFLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRDLKSLK 545
L L+ L L V + + ELP + GL L +L LS ++ R + + + LK L
Sbjct: 216 LGNLR-RLVCLDVSENRLEELPAELGGLVLLTDLL----LSQNLLRRLP-DGIGQLKQLS 269
Query: 546 ILSIKSN-VSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERI 604
IL + N + ++ +A+ D + + + N + + +L K+T LT L + LE +
Sbjct: 270 ILKVDQNRLCEVTEAIGDCENLSELILTEN--LLMALPRSLGKLTKLTNLNVDRNHLEAL 327
Query: 605 PHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLER 664
P + ++L L L++N L + H +L VL + N + +P + L +L+
Sbjct: 328 PPEIGGCVALSVLSLRDNRLAVLPP--ELAHTTELHVLDVAGNRLQSLPFALTHL-NLKA 384
Query: 665 LSFSHNKIE 673
L + N+ +
Sbjct: 385 LWLAENQAQ 393
>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
Length = 524
Score = 103 bits (257), Expect = 6e-22
Identities = 88/312 (28%), Positives = 150/312 (48%), Gaps = 22/312 (7%)
Query: 493 LKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLE---SLRDLKSLKILSI 549
L+ L + ++++ LPP + L EL D+SRN E S+ K+L++
Sbjct: 61 LRKLGLSDNEIQRLPPEIANFMQLVEL--------DVSRNEIPEIPESISFCKALQVADF 112
Query: 550 KSN-VSKIPQAVVDVSSHLQKMCIH-NDGTKLVMLNNLKKMTNLTELELVHCDLERIPHA 607
N ++++P++ ++ + C+ ND + + N+ + NL LEL L +P +
Sbjct: 113 SGNPLTRLPESFPELQN---LTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDS 169
Query: 608 VFSLLSLQELDLKENNLKSI-EEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLS 666
+ L L+ELDL N + ++ E I + HL+ L L N ++ +P+ I L +L L
Sbjct: 170 LTQLRRLEELDLGNNEIYNLPESIGALLHLKDLW---LDGNQLSELPQEIGNLKNLLCLD 226
Query: 667 FSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELY 726
S N++E LP + + L +S N + IP IG L+ L + N++ LP+ +
Sbjct: 227 VSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVG 286
Query: 727 FCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALKRAGLVVED 786
C+ L L + +N L L IG L LS L+ N LP E+G C +L V D
Sbjct: 287 ECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSL--TVFCVRD 344
Query: 787 ALFETLPSDVRE 798
+P++V +
Sbjct: 345 NRLTRIPAEVSQ 356
Score = 102 bits (254), Expect = 1e-21
Identities = 97/355 (27%), Positives = 166/355 (46%), Gaps = 14/355 (3%)
Query: 433 LSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKEN 492
L LP+ F++ +L+ L L + +P IA L EL + + + ++SF K
Sbjct: 48 LRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKA- 106
Query: 493 LKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRDLKSLKILSIKSN 552
L+V + + LP L+NL L + +DIS E++ +L +L L ++ N
Sbjct: 107 LQVADFSGNPLTRLPESFPELQNLTCLSV-----NDISLQSLPENIGNLYNLASLELREN 161
Query: 553 V-SKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSL 611
+ + +P ++ + L+++ + N+ + ++ + +L +L L L +P + +L
Sbjct: 162 LLTYLPDSLTQLR-RLEELDLGNNEI-YNLPESIGALLHLKDLWLDGNQLSELPQEIGNL 219
Query: 612 LSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNK 671
+L LD+ EN L+ + E +S L LT L + N + IP+ I KL L L N+
Sbjct: 220 KNLLCLDVSENRLERLPEEIS--GLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNR 277
Query: 672 IEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKL 731
+ LP + C + L L+ N + +P IG L+ L + NK+ SLP E+ C L
Sbjct: 278 LTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSL 337
Query: 732 KTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALKRAGLVVED 786
+ N L+ + ++ L LDV GN LP L ALK L + D
Sbjct: 338 TVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSL---TALKLKALWLSD 389
Score = 96.7 bits (239), Expect = 8e-20
Identities = 81/312 (25%), Positives = 150/312 (48%), Gaps = 12/312 (3%)
Query: 468 NLQELSLHQCSVKIHSAALSFLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSH 527
+++ + CS+ + +L+ L + + +RELP + L L +L LS
Sbjct: 13 HVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKL----GLSD 68
Query: 528 DISRNVTLESLRDLKSLKILSIKSNVSKIPQAVVDVSSHLQKMCIHN-DGTKLVML-NNL 585
+ + + E ++ +++ ++ + +IP+++ S + + + + G L L +
Sbjct: 69 NEIQRLPPEIANFMQLVELDVSRNEIPEIPESI----SFCKALQVADFSGNPLTRLPESF 124
Query: 586 KKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLW 645
++ NLT L + L+ +P + +L +L L+L+EN L + + S LR+L L L
Sbjct: 125 PELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPD--SLTQLRRLEELDLG 182
Query: 646 HNSITYIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVL 705
+N I +PE I L L+ L N++ LP + + LD+S N + +P EI L
Sbjct: 183 NNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGL 242
Query: 706 QSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFE 765
SL I+ N +E++PD + KKL LK+ +N L+ L +G L+ L + N
Sbjct: 243 TSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLL 302
Query: 766 ILPPELGDCRAL 777
LP +G + L
Sbjct: 303 TLPKSIGKLKKL 314
Score = 92.0 bits (227), Expect = 2e-18
Identities = 77/289 (26%), Positives = 136/289 (47%), Gaps = 12/289 (4%)
Query: 514 RNLEELYLVGSLSHDISRNVTLESLRDLKSLKILSIKSN-VSKIPQAVVDVSSHLQKMCI 572
R+LEEL L + ++ E L L+ L + N + ++P + + ++
Sbjct: 36 RSLEELLLDANQLRELP-----EQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVS 90
Query: 573 HNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVS 632
N+ ++ + K + + L R+P + L +L L + + +L+S+ E +
Sbjct: 91 RNEIPEIPESISFCKALQVADFS--GNPLTRLPESFPELQNLTCLSVNDISLQSLPENIG 148
Query: 633 FQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSY 692
+L L L+L N +TY+P+ + +L LE L +N+I LP + ++ L L
Sbjct: 149 --NLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDG 206
Query: 693 NDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLL 752
N + +P EIG L++L ++ N++E LP+E+ L L I +N L + IG L
Sbjct: 207 NQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLK 266
Query: 753 FLSYLDVKGNHFEILPPELGDCRALKRAGLVVEDALFETLPSDVREQMK 801
LS L V N LP +G+C +L LV+ + TLP + + K
Sbjct: 267 KLSILKVDQNRLTQLPEAVGECESLTE--LVLTENQLLTLPKSIGKLKK 313
Score = 70.5 bits (171), Expect = 6e-12
Identities = 49/169 (28%), Positives = 82/169 (48%), Gaps = 1/169 (0%)
Query: 614 LQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIE 673
++ +D + +L + E + +++ R L L L N + +PE +L L +L S N+I+
Sbjct: 14 VESIDKRHCSLVYVPEEI-YRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQ 72
Query: 674 VLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKT 733
LP + ++ LD+S N+I IP I ++LQ + N + LP+ + L
Sbjct: 73 RLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTC 132
Query: 734 LKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALKRAGL 782
L + SL L IGNL L+ L+++ N LP L R L+ L
Sbjct: 133 LSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDL 181
Score = 63.9 bits (154), Expect = 6e-10
Identities = 63/277 (22%), Positives = 127/277 (45%), Gaps = 34/277 (12%)
Query: 431 IMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLK 490
I L LP+ + + L SL+L +P ++ QL L+EL L
Sbjct: 138 ISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGN-------------- 183
Query: 491 ENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRDLKSLKILSIK 550
+++ LP + L +L++L+L G+ ++ + + +LK+L L +
Sbjct: 184 ----------NEIYNLPESIGALLHLKDLWLDGNQLSELP-----QEIGNLKNLLCLDVS 228
Query: 551 SN-VSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVF 609
N + ++P+ + ++S L + I + + + + + K+ L+ L++ L ++P AV
Sbjct: 229 ENRLERLPEEISGLTS-LTDLVISQNLLETIP-DGIGKLKKLSILKVDQNRLTQLPEAVG 286
Query: 610 SLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSH 669
SL EL L EN L ++ + S L+KL+ L N + +P+ I SL
Sbjct: 287 ECESLTELVLTENQLLTLPK--SIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRD 344
Query: 670 NKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQ 706
N++ +P+ + ++ LD++ N + +P + L+
Sbjct: 345 NRLTRIPAEVSQATELHVLDVAGNRLLHLPLSLTALK 381
Score = 63.9 bits (154), Expect = 6e-10
Identities = 79/304 (25%), Positives = 131/304 (43%), Gaps = 42/304 (13%)
Query: 426 LELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAA 485
LEL +L+ LPD++ ++ L+ L L + +P +I L +L++L L +
Sbjct: 156 LELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQE 215
Query: 486 LSFLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRDLKSLK 545
+ LK NL L V + + LP + GL +L +L + +L I + + LK L
Sbjct: 216 IGNLK-NLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIP-----DGIGKLKKLS 269
Query: 546 ILSIKSN-VSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERI 604
IL + N ++++P+AV + S LTEL L L +
Sbjct: 270 ILKVDQNRLTQLPEAVGECES-------------------------LTELVLTENQLLTL 304
Query: 605 PHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLER 664
P ++ L L L+ N L S+ + + LTV + N +T IP + + T L
Sbjct: 305 PKSIGKLKKLSNLNADRNKLVSLPKEIG--GCCSLTVFCVRDNRLTRIPAEVSQATELHV 362
Query: 665 LSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFS----ITCNKVES 720
L + N++ LP L K++ L LS N + P + Y + +TC +
Sbjct: 363 LDVAGNRLLHLPLSL-TALKLKALWLSDNQSQ---PLLTFQTDTDYTTGEKILTCVLLPQ 418
Query: 721 LPDE 724
LP E
Sbjct: 419 LPSE 422
>gi|4503743 flightless I homolog [Homo sapiens]
Length = 1269
Score = 100 bits (249), Expect = 5e-21
Identities = 97/365 (26%), Positives = 159/365 (43%), Gaps = 34/365 (9%)
Query: 437 PDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSL-HQCSVKIHSAALS-------- 487
P+ V +T L+ LKL +P +A L L+ LS+ H +H S
Sbjct: 26 PENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIV 85
Query: 488 ---------------FLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRN 532
F ++L VL + + + E P + +N+ LV +LSH+
Sbjct: 86 ARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNM----LVLNLSHNSIDT 141
Query: 533 VTLESLRDLKSLKILSIKSNVSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLT 592
+ + +L L L + N + + HLQ + ++ + L L MT L
Sbjct: 142 IPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQ 201
Query: 593 ELEL--VHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSIT 650
L L +P ++ L +L ++DL N+L + E + L L L L N IT
Sbjct: 202 TLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECL--YTLPSLRRLNLSSNQIT 259
Query: 651 YIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRF--IPPEIGVLQSL 708
+ I + +E L+ S N++ LPS + +K++ L L+ N + F +P IG L +L
Sbjct: 260 ELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNL 319
Query: 709 QYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILP 768
+ F N +E +P+ L C KL+ L + KN L L I L + LDV+ N ++P
Sbjct: 320 EEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMP 379
Query: 769 PELGD 773
P+ D
Sbjct: 380 PKPAD 384
Score = 73.2 bits (178), Expect = 9e-13
Identities = 68/286 (23%), Positives = 112/286 (39%), Gaps = 73/286 (25%)
Query: 584 NLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIE-EIVSFQHLRK---- 638
N+K MT+L L+L L +P + +L L+ L + NNL ++ E+ S LR
Sbjct: 28 NVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIVAR 87
Query: 639 ------------------LTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVLPSHLF 680
L+VL L HN +T P ++ ++ L+ SHN I+ +P+ LF
Sbjct: 88 ANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLF 147
Query: 681 L-CNKIRYLDLSYNDIRFIPPEIGVLQSLQYF---------------------------- 711
+ + YLDLS N + +PP++ L LQ
Sbjct: 148 INLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRS 207
Query: 712 ---------------------SITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGN 750
++CN + +P+ LY L+ L + N ++ LS I
Sbjct: 208 TQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQ 267
Query: 751 LLFLSYLDVKGNHFEILPPELGDCRALKRAGLVVEDALFETLPSDV 796
+ + L++ N LP + LK+ L F+ LPS +
Sbjct: 268 WVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGI 313
Score = 68.2 bits (165), Expect = 3e-11
Identities = 46/158 (29%), Positives = 74/158 (46%), Gaps = 3/158 (1%)
Query: 617 LDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVLP 676
+DL N+ K + + + L LKL + Y+PE + L LE LS SHN + L
Sbjct: 13 VDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLH 72
Query: 677 SHLFLCNKIRYLDLSYNDIR--FIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTL 734
L +R + N ++ +P +I L L ++ N++ P EL K + L
Sbjct: 73 GELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVL 132
Query: 735 KIGKNSLSVLSPKIG-NLLFLSYLDVKGNHFEILPPEL 771
+ NS+ + ++ NL L YLD+ N E LPP++
Sbjct: 133 NLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQM 170
>gi|33285015 leucine rich repeat containing 28 [Homo sapiens]
Length = 367
Score = 97.4 bits (241), Expect = 5e-20
Identities = 66/203 (32%), Positives = 106/203 (52%), Gaps = 5/203 (2%)
Query: 578 KLVMLNNLKKMTNL--TELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQH 635
K + + L+K NL L H LE + L L+ L +K N+L S+ E ++ Q
Sbjct: 7 KTISVARLEKHKNLFLNYRNLHHFPLELLKDE--GLQYLERLYMKRNSLTSLPENLA-QK 63
Query: 636 LRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDI 695
L L L L N+I +PE I L L+ L S N +E++ + +R+L L+ N +
Sbjct: 64 LPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQL 123
Query: 696 RFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLS 755
+F+PPE+G L+ LQ I+ N++ +LP+ L+ C L+ L + +N L + + L L+
Sbjct: 124 QFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPSLN 183
Query: 756 YLDVKGNHFEILPPELGDCRALK 778
L + GN LP +LG R L+
Sbjct: 184 ELSMAGNRLAFLPLDLGRSRELQ 206
Score = 80.1 bits (196), Expect = 7e-15
Identities = 49/174 (28%), Positives = 93/174 (53%), Gaps = 2/174 (1%)
Query: 566 HLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLK 625
+L+++ + + + N +K+ NL EL L ++ +P A+ SL+ LQ LDL +N L+
Sbjct: 42 YLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALE 101
Query: 626 SIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKI 685
+ + LR L L+L +N + ++P + L L+ L S N++ LP L +C +
Sbjct: 102 IVCPEIG--RLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSL 159
Query: 686 RYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKN 739
+YL + N + ++P + L SL S+ N++ LP +L ++L+ + + N
Sbjct: 160 QYLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDNN 213
Score = 47.8 bits (112), Expect = 4e-05
Identities = 38/117 (32%), Positives = 58/117 (49%), Gaps = 6/117 (5%)
Query: 684 KIRYLDLSYNDIRFIPPEIGVLQSLQYFS---ITCNKVESLPDEL-YFCKKLKTLKIGKN 739
K + L L+Y ++ P E+ + LQY + N + SLP+ L L L + N
Sbjct: 16 KHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSN 75
Query: 740 SLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALKRAGLVVEDALFETLPSDV 796
++ V+ IG+L+ L LD+ N EI+ PE+G RAL+ L F LP +V
Sbjct: 76 NIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQF--LPPEV 130
>gi|61742786 leucine rich repeat and death domain containing protein
isoform 3 [Homo sapiens]
Length = 893
Score = 96.7 bits (239), Expect = 8e-20
Identities = 60/181 (33%), Positives = 98/181 (54%), Gaps = 2/181 (1%)
Query: 601 LERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLT 660
L +P + L L LDL N+L+++ V +R L L L HN ++ +PE + L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVL--QMRGLGALLLSHNCLSELPEALGALP 171
Query: 661 SLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVES 720
+L L+ +HN+++ LP L + ++ LDLS N + +PPEIG L SL ++ N+++S
Sbjct: 172 ALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQS 231
Query: 721 LPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALKRA 780
LP L + L+ L + N L+ + + L L+ LD++ N LPPEL D ++
Sbjct: 232 LPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVRLQ 291
Query: 781 G 781
G
Sbjct: 292 G 292
Score = 76.6 bits (187), Expect = 8e-14
Identities = 49/174 (28%), Positives = 88/174 (50%), Gaps = 2/174 (1%)
Query: 623 NLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVLPSHLFLC 682
+L + +V R+ T+ ++T +P + L L L S N +E LP+ +
Sbjct: 88 SLSCLRSLVLKGGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQM 147
Query: 683 NKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLS 742
+ L LS+N + +P +G L +L + ++T N++++LP L L+ L + +N L
Sbjct: 148 RGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLD 207
Query: 743 VLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALKRAGLVVEDALFETLPSDV 796
L P+IG L L L++ N + LP L R+L+ LV+ L ++P+D+
Sbjct: 208 TLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRL--LVLHSNLLASVPADL 259
Score = 32.3 bits (72), Expect = 1.8
Identities = 27/87 (31%), Positives = 42/87 (48%), Gaps = 7/87 (8%)
Query: 425 RLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQ---CSVKI 481
RL+L +L LP + + L L L + +PA++A L +L+ L LH SV
Sbjct: 198 RLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPA 257
Query: 482 HSAALSFLKENLKVLSVKFDDMRELPP 508
A L L L ++ + +R+LPP
Sbjct: 258 DLARLPLLTR----LDLRDNQLRDLPP 280
>gi|61742784 leucine rich repeat and death domain containing protein
isoform 1 [Homo sapiens]
Length = 910
Score = 96.7 bits (239), Expect = 8e-20
Identities = 60/181 (33%), Positives = 98/181 (54%), Gaps = 2/181 (1%)
Query: 601 LERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLT 660
L +P + L L LDL N+L+++ V +R L L L HN ++ +PE + L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVL--QMRGLGALLLSHNCLSELPEALGALP 171
Query: 661 SLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVES 720
+L L+ +HN+++ LP L + ++ LDLS N + +PPEIG L SL ++ N+++S
Sbjct: 172 ALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQS 231
Query: 721 LPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALKRA 780
LP L + L+ L + N L+ + + L L+ LD++ N LPPEL D ++
Sbjct: 232 LPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVRLQ 291
Query: 781 G 781
G
Sbjct: 292 G 292
Score = 76.6 bits (187), Expect = 8e-14
Identities = 49/174 (28%), Positives = 88/174 (50%), Gaps = 2/174 (1%)
Query: 623 NLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVLPSHLFLC 682
+L + +V R+ T+ ++T +P + L L L S N +E LP+ +
Sbjct: 88 SLSCLRSLVLKGGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQM 147
Query: 683 NKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLS 742
+ L LS+N + +P +G L +L + ++T N++++LP L L+ L + +N L
Sbjct: 148 RGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLD 207
Query: 743 VLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALKRAGLVVEDALFETLPSDV 796
L P+IG L L L++ N + LP L R+L+ LV+ L ++P+D+
Sbjct: 208 TLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRL--LVLHSNLLASVPADL 259
Score = 32.3 bits (72), Expect = 1.8
Identities = 27/87 (31%), Positives = 42/87 (48%), Gaps = 7/87 (8%)
Query: 425 RLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQ---CSVKI 481
RL+L +L LP + + L L L + +PA++A L +L+ L LH SV
Sbjct: 198 RLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPA 257
Query: 482 HSAALSFLKENLKVLSVKFDDMRELPP 508
A L L L ++ + +R+LPP
Sbjct: 258 DLARLPLLTR----LDLRDNQLRDLPP 280
>gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens]
Length = 277
Score = 95.1 bits (235), Expect = 2e-19
Identities = 51/165 (30%), Positives = 89/165 (53%), Gaps = 2/165 (1%)
Query: 616 ELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVL 675
E+D+ + + ++ ++ L +T L L HN +T +P +I +L +LE L+F +N+IE L
Sbjct: 19 EVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEEL 78
Query: 676 PSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKV--ESLPDELYFCKKLKT 733
P+ + K+++L+L N + +P G L +L+ +T N + SLP ++ L+
Sbjct: 79 PTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRA 138
Query: 734 LKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALK 778
L + N +L P IG L L L ++ N LP E+G+ LK
Sbjct: 139 LYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLK 183
Score = 92.8 bits (229), Expect = 1e-18
Identities = 69/212 (32%), Positives = 108/212 (50%), Gaps = 14/212 (6%)
Query: 542 KSLKILSIKSNVSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDL 601
KSLK L +S P+ VD+S + ++ +N L ++++T+L L H L
Sbjct: 3 KSLKKLVEESREKNQPE--VDMSDR--------GISNMLDVNGLFTLSHITQLVLSHNKL 52
Query: 602 ERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTS 661
+P + L +L+ L+ N ++ + +S L+KL L L N + +P L +
Sbjct: 53 TMVPPNIAELKNLEVLNFFNNQIEELPTQIS--SLQKLKHLNLGMNRLNTLPRGFGSLPA 110
Query: 662 LERLSFSHNKIEV--LPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVE 719
LE L ++N + LP + F +R L LS ND +PP+IG L LQ S+ N +
Sbjct: 111 LEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLI 170
Query: 720 SLPDELYFCKKLKTLKIGKNSLSVLSPKIGNL 751
SLP E+ +LK L I N L+VL P++GNL
Sbjct: 171 SLPKEIGELTQLKELHIQGNRLTVLPPELGNL 202
Score = 40.0 bits (92), Expect = 0.009
Identities = 52/229 (22%), Positives = 100/229 (43%), Gaps = 15/229 (6%)
Query: 440 VFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKENLKVLSVK 499
+F ++ + L L K M+P IA+L NL+ L+ ++ +S L + LK L++
Sbjct: 36 LFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSL-QKLKHLNLG 94
Query: 500 FDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRDLKSLKILSIKSNVSKIPQA 559
+ + LP G +L L ++ +++S N + L +L+ L + N +I
Sbjct: 95 MNRLNTLP---RGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPP 151
Query: 560 VVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSL-LSLQELD 618
+ + LQ + + D + + + ++T L EL + L +P + +L L+ Q+
Sbjct: 152 DIGKLTKLQILSL-RDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQV 210
Query: 619 LKENNLKSIEEIVS---------FQHLRKLTVLKLWHNSITYIPEHIKK 658
K N + I F+++R T L+ + PE KK
Sbjct: 211 FKAENNPWVTPIADQFQLGVSHVFEYIRSETYKYLYGRHMQANPEPPKK 259
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 94.7 bits (234), Expect = 3e-19
Identities = 84/321 (26%), Positives = 153/321 (47%), Gaps = 13/321 (4%)
Query: 464 AQLDNLQELSLHQCSVKIHSAALSFLKENLKVLSVKFDDMRELPPWMYGL-RNLEELYLV 522
A L +++ L+L ++ L +L+VL ++ + LPP + L +L EL
Sbjct: 60 ANLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTEL--- 116
Query: 523 GSLSHDISRNVTLESLRDLKSLKILSIKSNVSKIPQAVVDVSSHLQKMCIHNDGTKLVML 582
+SH+ + E + L+ L+ L++ N A + +HL+++ + + +L L
Sbjct: 117 -DVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFN--RLAHL 173
Query: 583 -NNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTV 641
++L ++ L L++ H L P + L++L+ELD+ N L+ + E +S LR L +
Sbjct: 174 PDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISA--LRALKI 231
Query: 642 LKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPE 701
L L + +P +L SLE L +N ++ LP+ +++ L+LS N P
Sbjct: 232 LWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAA 291
Query: 702 IGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKG 761
+ L L+ ++ N++ S+P + +L TL + N + L I L L L ++G
Sbjct: 292 LLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQG 351
Query: 762 NHFEILPPELGDCRALKRAGL 782
N +LP G L R GL
Sbjct: 352 NQIAVLPDHFGQ---LSRVGL 369
Score = 83.2 bits (204), Expect = 9e-16
Identities = 68/241 (28%), Positives = 113/241 (46%), Gaps = 7/241 (2%)
Query: 557 PQAVVDVS-SHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSL-LSL 614
PQ V+ + ++ + + N+G + V + +L L L R+P AV L L
Sbjct: 54 PQLVLPANLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHL 113
Query: 615 QELDLKENNLKSI-EEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIE 673
ELD+ N L ++ E+VS LR+L L L HN + +P + L LE L S N++
Sbjct: 114 TELDVSHNRLTALGAEVVSA--LRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLA 171
Query: 674 VLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKT 733
LP L +++R LD+ +N + P ++ L +L+ ++ N++ LP+++ + LK
Sbjct: 172 HLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKI 231
Query: 734 LKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALKRAGLVVEDALFETLP 793
L + L L L L L + N + LP + + LK L LFE P
Sbjct: 232 LWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNL--SSNLFEEFP 289
Query: 794 S 794
+
Sbjct: 290 A 290
Score = 77.8 bits (190), Expect = 4e-14
Identities = 75/269 (27%), Positives = 125/269 (46%), Gaps = 17/269 (6%)
Query: 438 DTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKENLKVLS 497
+ V + EL+ L L + +PA + L +L+EL + + +LS L L+ L
Sbjct: 129 EVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSR-LRTLD 187
Query: 498 VKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTL---ESLRDLKSLKILSIK-SNV 553
V + + P + L LEEL D+S N E + L++LKIL + + +
Sbjct: 188 VDHNQLTAFPRQLLQLVALEEL--------DVSSNRLRGLPEDISALRALKILWLSGAEL 239
Query: 554 SKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSLLS 613
+P +++S L+ + + N+G + + + L L L E P A+ L
Sbjct: 240 GTLPAGFCELAS-LESLMLDNNGLQALPAQ-FSCLQRLKMLNLSSNLFEEFPAALLPLAG 297
Query: 614 LQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIE 673
L+EL L N L S+ ++S L +L L L +N I Y+P+ I +LT LE L N+I
Sbjct: 298 LEELYLSRNQLTSVPSLIS--GLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIA 355
Query: 674 VLPSHLFLCNKIRYLDLSYNDIRFIPPEI 702
VLP H +++ + N + P E+
Sbjct: 356 VLPDHFGQLSRVGLWKIKDNPLIQPPYEV 384
Score = 47.0 bits (110), Expect = 7e-05
Identities = 47/173 (27%), Positives = 81/173 (46%), Gaps = 19/173 (10%)
Query: 398 NKLKQLNLNNEWTPDKLRQKLQTNAHNRLELPLIMLSGLPDTVFEITELQSLKLEIIKNV 457
++L+ L++++ RQ LQ A L++ L GLP+ + + L+ L L +
Sbjct: 181 SRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELG 240
Query: 458 MIPATIAQLDNLQELSLHQCSVKIHSAALSFLKENLKVLSVKFDDMRELPPWMYGLRNLE 517
+PA +L +L+ L L ++ A S L + LK+L++ + E P + L LE
Sbjct: 241 TLPAGFCELASLESLMLDNNGLQALPAQFSCL-QRLKMLNLSSNLFEEFPAALLPLAGLE 299
Query: 518 ELYL-------VGSLSHDISRNVTL-----------ESLRDLKSLKILSIKSN 552
ELYL V SL + R +TL +S+ +L L+ L ++ N
Sbjct: 300 ELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGN 352
>gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo
sapiens]
Length = 560
Score = 91.7 bits (226), Expect = 2e-18
Identities = 78/310 (25%), Positives = 143/310 (46%), Gaps = 10/310 (3%)
Query: 488 FLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRDLKSLKIL 547
F L+ + ++ + + E+P + L+N+ LYL + + + L L SL+ L
Sbjct: 45 FTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPALGL-----LSSLESL 99
Query: 548 SIKSN-VSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPH 606
+ N + VV L+++ ++ K + + K + +L L L L+ +P
Sbjct: 100 DLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPK 159
Query: 607 AVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLS 666
+ + L+E+ LK N + + + L L ++ L N I IPE I LT L++
Sbjct: 160 EIVNQTKLREIYLKRNQFEVFPQELCV--LYTLEIIDLDENKIGAIPEEIGHLTGLQKFY 217
Query: 667 FSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELY 726
+ N + VLP+ L C+++ LDLS+N + IP L+ + ++ N++E +P +
Sbjct: 218 MASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLIC 277
Query: 727 FCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALKRAGLVVED 786
L L +G L L L+ L +LD+ NH P ++ + L+ GL +D
Sbjct: 278 RWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGL--DD 335
Query: 787 ALFETLPSDV 796
LPS++
Sbjct: 336 NKIGQLPSEL 345
Score = 89.4 bits (220), Expect = 1e-17
Identities = 93/403 (23%), Positives = 180/403 (44%), Gaps = 30/403 (7%)
Query: 380 YDPLYSKRFAV--FLSEVSENKLKQLNLNNEWTPDKLRQKLQTNAHNRLELPLIMLSG-- 435
Y+P++S V FL + E +L Q +L ++ + N H+ L L+ L+G
Sbjct: 103 YNPIFSSSLVVVSFLHALRELRLYQTDLK------EIPVVIFKNLHH---LELLGLTGNH 153
Query: 436 ---LPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKEN 492
LP + T+L+ + L+ + + P + L L+ + L + + + L
Sbjct: 154 LKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLT-G 212
Query: 493 LKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRDLKSLKILSIKSN 552
L+ + +++ LP + L L L +L H I + S +L+ + + + N
Sbjct: 213 LQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPK-----SFAELRKMTEIGLSGN 267
Query: 553 -VSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSL 611
+ K+P+ + +S L + + N G + + + + NL L+L L P + +L
Sbjct: 268 RLEKVPRLICRWTS-LHLLYLGNTGLHRLR-GSFRCLVNLRFLDLSQNHLHHCPLQICAL 325
Query: 612 LSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHN- 670
+L+ L L +N + + + L KL +L L N PE + L SLE+L +
Sbjct: 326 KNLEVLGLDDNKIGQLPSELG--SLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQ 383
Query: 671 --KIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFC 728
K+ +P H+ ++ L + N + ++P +G + +L+ N ++ LPD +
Sbjct: 384 GFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQA 443
Query: 729 KKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPEL 771
+ LK L++ N L+ L + +L+ L L + N E P E+
Sbjct: 444 QALKELRLEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEV 486
Score = 84.0 bits (206), Expect = 5e-16
Identities = 95/392 (24%), Positives = 176/392 (44%), Gaps = 45/392 (11%)
Query: 433 LSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKEN 492
L+ +P +F TEL+ + LE + IP I +L N++ L L + +++ AL L +
Sbjct: 37 LTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPALGLLS-S 95
Query: 493 LKVLSVKFDDMRE----LPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRDLKSLKILS 548
L+ L + ++ + + +++ LR L L + + + ++L L++L
Sbjct: 96 LESLDLSYNPIFSSSLVVVSFLHALRELR-------LYQTDLKEIPVVIFKNLHHLELLG 148
Query: 549 IKSNVSK-IPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHA 607
+ N K +P+ +V+ + L+++ + + + V L + L ++L + IP
Sbjct: 149 LTGNHLKCLPKEIVN-QTKLREIYLKRNQFE-VFPQELCVLYTLEIIDLDENKIGAIPEE 206
Query: 608 VFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSF 667
+ L LQ+ + NNL + S +L+VL L HN + IP+ +L + +
Sbjct: 207 IGHLTGLQKFYMASNNLPVLP--ASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGL 264
Query: 668 SHNKIEVLPS--------HL--------------FLC-NKIRYLDLSYNDIRFIPPEIGV 704
S N++E +P HL F C +R+LDLS N + P +I
Sbjct: 265 SGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICA 324
Query: 705 LQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDV---KG 761
L++L+ + NK+ LP EL KLK L + N ++ +L L L + +G
Sbjct: 325 LKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQG 384
Query: 762 NHFEILPPELGDCRALKRAGLVVEDALFETLP 793
+P + ++LK L +E+ E LP
Sbjct: 385 FKLTYVPEHIRKLQSLKE--LYIENNHLEYLP 414
Score = 61.2 bits (147), Expect = 4e-09
Identities = 44/153 (28%), Positives = 76/153 (49%), Gaps = 4/153 (2%)
Query: 646 HNSITYIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVL 705
+ S+T IP I T LE + +N+IE +P + IR L L N++R + P +G+L
Sbjct: 34 NQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPALGLL 93
Query: 706 QSLQYFSITCNKV-ESLPDELYFCKKLKTLKIGKNSLSVLSPKI-GNLLFLSYLDVKGNH 763
SL+ ++ N + S + F L+ L++ + L + I NL L L + GNH
Sbjct: 94 SSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNH 153
Query: 764 FEILPPELGDCRALKRAGLVVEDALFETLPSDV 796
+ LP E+ + L+ + ++ FE P ++
Sbjct: 154 LKCLPKEIVNQTKLRE--IYLKRNQFEVFPQEL 184
Score = 45.8 bits (107), Expect = 2e-04
Identities = 30/106 (28%), Positives = 52/106 (49%), Gaps = 4/106 (3%)
Query: 657 KKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCN 716
K + S+E H + + P H+ ++ ++D S + IP EI L+ + N
Sbjct: 3 KDIKSVEHSPKIHQRND--PQHVN--DRTFFIDASNQSLTAIPLEIFTFTELEEVHLENN 58
Query: 717 KVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGN 762
++E +P E+ K ++ L + KN+L L P +G L L LD+ N
Sbjct: 59 QIEEIPQEIQRLKNIRVLYLDKNNLRSLCPALGLLSSLESLDLSYN 104
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 88.6 bits (218), Expect = 2e-17
Identities = 61/227 (26%), Positives = 108/227 (47%), Gaps = 5/227 (2%)
Query: 552 NVSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSL 611
N+S++PQ V ++ + + N + T+LT+L + + L+ + + L
Sbjct: 47 NLSEVPQCVWRINVDIPEEA--NQNLSFGATERWWEQTDLTKLIISNNKLQSLTDDLRLL 104
Query: 612 LSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNK 671
+L LD+ +N L S+ + + L L L + HN + +PE I L +L+ L HN+
Sbjct: 105 PALTVLDIHDNQLTSLPSAI--RELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNE 162
Query: 672 IEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKL 731
+ + + + LDLS N + +P L SL +++ N+++SLP E+ K+L
Sbjct: 163 LTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRL 222
Query: 732 KTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALK 778
K L N L + P++ + L L ++ N L PE C LK
Sbjct: 223 KHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFL-PEFPSCSLLK 268
Score = 84.7 bits (208), Expect = 3e-16
Identities = 101/449 (22%), Positives = 192/449 (42%), Gaps = 80/449 (17%)
Query: 395 VSENKLKQLNLNNEWTPDKLRQKLQTNAHNR--LELPLIMLSGLPDTVFEITELQSLKLE 452
VS NKLK L P+++ TN N L L L+ + + +++ L+ L L
Sbjct: 135 VSHNKLKIL-------PEEI-----TNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLS 182
Query: 453 IIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKENLKVLSVKFDDMRELPPWMYG 512
+PA+ + L +L L+L +K A ++ +K LK L + + +PP + G
Sbjct: 183 NNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKR-LKHLDCNSNLLETIPPELAG 241
Query: 513 LRNLEELYLVGS------------------LSHDISRNVTLESLRDLKSLKILSIKSNVS 554
+ +LE LYL + + + + E L+ L S+ +L ++ N
Sbjct: 242 MESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKL 301
Query: 555 K-IPQAVV-------------DVSS--------HLQKMCIHNDGTKLVMLNNLKKMT--- 589
K +P ++ D+SS HL+ + + + + + + K T
Sbjct: 302 KSVPDEIILLRSLERLDLSNNDISSLPYSLGNLHLKFLALEGNPLRTIRREIISKGTQEV 361
Query: 590 -----------------NLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSI-EEIV 631
+ TE + R+ + ++++L+ LD + I +E+
Sbjct: 362 LKYLRSKIKDDGPSQSESATETAMTLPSESRVN--IHAIITLKILDYSDKQATLIPDEVF 419
Query: 632 SFQHLRKLTVLKLWHNSITYIPEHIKKLTSL-ERLSFSHNKIEVLPSHLFLCNKIRYLDL 690
+T + N + IP+ + +L + + S NK+ + L + K+ +LDL
Sbjct: 420 DAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDL 479
Query: 691 SYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSP-KIG 749
N + +P E+ L LQ +++ N+ + LP+ LY L+T+ I N + + P K+
Sbjct: 480 RNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMK 539
Query: 750 NLLFLSYLDVKGNHFEILPPELGDCRALK 778
+ L+ LD++ N +PPELG+C L+
Sbjct: 540 MMENLTTLDLQNNDLLQIPPELGNCVNLR 568
Score = 82.4 bits (202), Expect = 2e-15
Identities = 81/293 (27%), Positives = 140/293 (47%), Gaps = 14/293 (4%)
Query: 435 GLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKENLK 494
G + +E T+L L + K + + L L L +H + +A+ L ENL+
Sbjct: 73 GATERWWEQTDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIREL-ENLQ 131
Query: 495 VLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRDLKSLKILSIKSN-V 553
L+V + ++ LP + LRNL+ LYL + IS E L +L+ L + +N +
Sbjct: 132 KLNVSHNKLKILPEEITNLRNLKCLYLQHNELTCIS-----EGFEQLSNLEDLDLSNNHL 186
Query: 554 SKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSLLS 613
+ +P + +SS ++ N+ L + +M L L+ LE IP + + S
Sbjct: 187 TTVPASFSSLSSLVRLNLSSNELKSLPA--EINRMKRLKHLDCNSNLLETIPPELAGMES 244
Query: 614 LQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYI-PEHIKKLTSLERLSFSHNKI 672
L+ L L+ N L+ + E S L++L V N I + EH+K L S+ L NK+
Sbjct: 245 LELLYLRRNKLRFLPEFPSCSLLKELHV---GENQIEMLEAEHLKHLNSILVLDLRDNKL 301
Query: 673 EVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDEL 725
+ +P + L + LDLS NDI +P +G L L++ ++ N + ++ E+
Sbjct: 302 KSVPDEIILLRSLERLDLSNNDISSLPYSLGNLH-LKFLALEGNPLRTIRREI 353
Score = 66.2 bits (160), Expect = 1e-10
Identities = 40/142 (28%), Positives = 71/142 (50%), Gaps = 2/142 (1%)
Query: 660 TSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVE 719
T L +L S+NK++ L L L + LD+ N + +P I L++LQ +++ NK++
Sbjct: 82 TDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLK 141
Query: 720 SLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALKR 779
LP+E+ + LK L + N L+ +S L L LD+ NH +P +L R
Sbjct: 142 ILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVR 201
Query: 780 AGLVVEDALFETLPSDVREQMK 801
L + ++LP+++ +
Sbjct: 202 LNLSSNE--LKSLPAEINRMKR 221
Score = 38.9 bits (89), Expect = 0.019
Identities = 24/99 (24%), Positives = 48/99 (48%)
Query: 426 LELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAA 485
L+L L+ LP+ + + LQ++ L + M+P + ++ L+ + + V
Sbjct: 477 LDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQ 536
Query: 486 LSFLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGS 524
+ ENL L ++ +D+ ++PP + NL L L G+
Sbjct: 537 KMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGN 575
Score = 33.1 bits (74), Expect = 1.1
Identities = 25/87 (28%), Positives = 44/87 (50%)
Query: 536 ESLRDLKSLKILSIKSNVSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELE 595
E + L L+ +++ N K+ V+ L+ + I N+ V +K M NLT L+
Sbjct: 489 EEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLD 548
Query: 596 LVHCDLERIPHAVFSLLSLQELDLKEN 622
L + DL +IP + + ++L+ L L N
Sbjct: 549 LQNNDLLQIPPELGNCVNLRTLLLDGN 575
>gi|61742782 leucine rich repeat and death domain containing protein
isoform 2 [Homo sapiens]
Length = 753
Score = 86.7 bits (213), Expect = 8e-17
Identities = 50/146 (34%), Positives = 82/146 (56%)
Query: 636 LRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDI 695
+R L L L HN ++ +PE + L +L L+ +HN+++ LP L + ++ LDLS N +
Sbjct: 1 MRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLL 60
Query: 696 RFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLS 755
+PPEIG L SL ++ N+++SLP L + L+ L + N L+ + + L L+
Sbjct: 61 DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLT 120
Query: 756 YLDVKGNHFEILPPELGDCRALKRAG 781
LD++ N LPPEL D ++ G
Sbjct: 121 RLDLRDNQLRDLPPELLDAPFVRLQG 146
Score = 39.7 bits (91), Expect = 0.011
Identities = 25/93 (26%), Positives = 42/93 (45%), Gaps = 23/93 (24%)
Query: 690 LSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIG 749
LS+N + +P +G L +L + ++T N++++LP P +G
Sbjct: 9 LSHNCLSELPEALGALPALTFLTVTHNRLQTLP-----------------------PALG 45
Query: 750 NLLFLSYLDVKGNHFEILPPELGDCRALKRAGL 782
L L LD+ N + LPPE+G +L L
Sbjct: 46 ALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNL 78
Score = 32.3 bits (72), Expect = 1.8
Identities = 27/87 (31%), Positives = 42/87 (48%), Gaps = 7/87 (8%)
Query: 425 RLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQ---CSVKI 481
RL+L +L LP + + L L L + +PA++A L +L+ L LH SV
Sbjct: 52 RLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPA 111
Query: 482 HSAALSFLKENLKVLSVKFDDMRELPP 508
A L L L ++ + +R+LPP
Sbjct: 112 DLARLPLLTR----LDLRDNQLRDLPP 134
>gi|193788651 leucine rich repeat containing 69 [Homo sapiens]
Length = 347
Score = 84.3 bits (207), Expect = 4e-16
Identities = 62/223 (27%), Positives = 105/223 (47%), Gaps = 40/223 (17%)
Query: 577 TKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHL 636
TK++ LN KKMT ++P A+ L L+ L L+ N + + +L
Sbjct: 16 TKIITLNG-KKMT-------------KMPSALGKLPGLKTLVLQNNLIPKV--CPELCNL 59
Query: 637 RKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKI------------------------ 672
+LT L L +N + +PE +K LTSL+ L S N+I
Sbjct: 60 TQLTTLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHL 119
Query: 673 EVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLK 732
LP + + Y+ ++YN + IP E+ L++L + N++ +P+E+ F KKL+
Sbjct: 120 TQLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQ 179
Query: 733 TLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDCR 775
L + +N++ VL ++ +L L LD+ GN +I P D +
Sbjct: 180 KLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDLK 222
Score = 67.4 bits (163), Expect = 5e-11
Identities = 60/224 (26%), Positives = 106/224 (47%), Gaps = 13/224 (5%)
Query: 491 ENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRDLKSLKILSIK 550
+N K++++ M ++P + L L+ L L +L + L +L L L++
Sbjct: 14 KNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVC-----PELCNLTQLTTLNLG 68
Query: 551 SNV-SKIPQAVVDVSSHLQKMCIHNDGTKLVML--NNLKKMTNLTELELVHCDLERIPHA 607
+N+ ++P+ + ++S +H G ++ + NL L L + L ++P
Sbjct: 69 NNLLEEVPEEMKYLTSLKN---LHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQE 125
Query: 608 VFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSF 667
V L SL + + N L SI + F L L L+L +N + IPE IK L L++L
Sbjct: 126 VSRLKSLTYMSINYNQLASIPRELCF--LENLVELQLNYNQLICIPEEIKFLKKLQKLLL 183
Query: 668 SHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYF 711
+ N I VLP L K+R LD++ N I+ P L+ +++
Sbjct: 184 ARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDLKLREFY 227
Score = 32.3 bits (72), Expect = 1.8
Identities = 24/93 (25%), Positives = 45/93 (48%), Gaps = 1/93 (1%)
Query: 433 LSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKEN 492
L+ LP V + L + + + IP + L+NL EL L+ + + FLK+
Sbjct: 119 LTQLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKL 178
Query: 493 LKVLSVKFDDMRELPPWMYGLRNLEELYLVGSL 525
K+L + +++ LP + L+ L L + G++
Sbjct: 179 QKLLLAR-NNIGVLPEELCDLKKLRILDIAGNI 210
Score = 31.6 bits (70), Expect = 3.1
Identities = 23/72 (31%), Positives = 36/72 (50%), Gaps = 2/72 (2%)
Query: 713 ITCN--KVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPE 770
IT N K+ +P L LKTL + N + + P++ NL L+ L++ N E +P E
Sbjct: 19 ITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEE 78
Query: 771 LGDCRALKRAGL 782
+ +LK L
Sbjct: 79 MKYLTSLKNLHL 90
>gi|21389431 leucine rich repeat containing 39 [Homo sapiens]
Length = 335
Score = 82.0 bits (201), Expect = 2e-15
Identities = 57/187 (30%), Positives = 93/187 (49%), Gaps = 3/187 (1%)
Query: 583 NNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVL 642
++L K+ L E +L L +IP + +L LDL N + I + L +L L
Sbjct: 77 SSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGL--LTRLQEL 134
Query: 643 KLWHNSITYIPEHIKKLTSLERLSFSHNK-IEVLPSHLFLCNKIRYLDLSYNDIRFIPPE 701
L +N I +P+ + SLE+L + N+ I LP L K+ +LDLS ND IP
Sbjct: 135 ILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLA 194
Query: 702 IGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKG 761
+ + +L++ + NK+E LPD + + L TL + +N ++ L I N+ L L +
Sbjct: 195 VLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSN 254
Query: 762 NHFEILP 768
N + +P
Sbjct: 255 NKLQDIP 261
Score = 79.0 bits (193), Expect = 2e-14
Identities = 82/320 (25%), Positives = 150/320 (46%), Gaps = 50/320 (15%)
Query: 392 LSEVSENKLKQLNLNNEWTPDKLRQKLQTNAHNRLELPLIMLSGLPDTVFEITELQSLKL 451
+ EV E ++K+LN D R+K + R+ + L+ L + V LK+
Sbjct: 14 VKEVWEKRIKKLN------EDLKREKEFQHKLVRIWEERVSLTKLREKVTREDGRVILKI 67
Query: 452 EIIKNVMIPATIAQLDNLQELSLHQCSV-KIHSAALSFLKENLKVLSVKFDDMRELPPWM 510
E + +P+++ +L+ LQE LH+ + KI F +NL VL + + + E+PP +
Sbjct: 68 EKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRF--QNLIVLDLSRNTISEIPPGI 125
Query: 511 YGLRNLEELYL----VGSLSHDISRNVTLESLRDLKSLKILSIKSNVSKIPQAVVDVSSH 566
L L+EL L + ++ ++S +LE L L++ ++ +PQ
Sbjct: 126 GLLTRLQELILSYNKIKTVPKELSNCASLEKLE-------LAVNRDICDLPQE------- 171
Query: 567 LQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKS 626
L+NL K LT L+L D IP AV ++ +L+ LD+ N L+
Sbjct: 172 ---------------LSNLLK---LTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQ 213
Query: 627 IEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIR 686
+ + + + ++ L L L N IT +P+ I + +L L S+NK++ +P + +R
Sbjct: 214 LPDTI--ERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLR 271
Query: 687 YLDLSYNDIRF---IPPEIG 703
+++ N ++ +PP G
Sbjct: 272 FVNFRDNPLKLKVSLPPSEG 291
Score = 74.7 bits (182), Expect = 3e-13
Identities = 57/196 (29%), Positives = 92/196 (46%), Gaps = 5/196 (2%)
Query: 604 IPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLE 663
+P ++ L LQE L L I E + + L VL L N+I+ IP I LT L+
Sbjct: 75 LPSSLLKLNQLQEWQLHRTGLLKIPEFIG--RFQNLIVLDLSRNTISEIPPGIGLLTRLQ 132
Query: 664 RLSFSHNKIEVLPSHLFLCNKIRYLDLSYN-DIRFIPPEIGVLQSLQYFSITCNKVESLP 722
L S+NKI+ +P L C + L+L+ N DI +P E+ L L + ++ N ++P
Sbjct: 133 ELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIP 192
Query: 723 DELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALKRAGL 782
+ L+ L +G N L L I + L L ++ N LP + + + L L
Sbjct: 193 LAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNL--GTL 250
Query: 783 VVEDALFETLPSDVRE 798
V+ + + +P + E
Sbjct: 251 VLSNNKLQDIPVCMEE 266
Score = 68.9 bits (167), Expect = 2e-11
Identities = 49/162 (30%), Positives = 81/162 (50%), Gaps = 8/162 (4%)
Query: 615 QELDLKENNLKSIEEIVSFQHLR-KLT------VLKLWHNSITYIPEHIKKLTSLERLSF 667
+E + + ++ EE VS LR K+T +LK+ +P + KL L+
Sbjct: 31 REKEFQHKLVRIWEERVSLTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQL 90
Query: 668 SHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYF 727
+ +P + + LDLS N I IPP IG+L LQ ++ NK++++P EL
Sbjct: 91 HRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSN 150
Query: 728 CKKLKTLKIGKN-SLSVLSPKIGNLLFLSYLDVKGNHFEILP 768
C L+ L++ N + L ++ NLL L++LD+ N F +P
Sbjct: 151 CASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIP 192
Score = 68.6 bits (166), Expect = 2e-11
Identities = 71/278 (25%), Positives = 124/278 (44%), Gaps = 18/278 (6%)
Query: 509 WMYGLRNL-EELYLVGSLSHDISR----NVTLESLRDLKSLK----ILSIKSNVSK-IPQ 558
W ++ L E+L H + R V+L LR+ + + IL I+ K +P
Sbjct: 18 WEKRIKKLNEDLKREKEFQHKLVRIWEERVSLTKLREKVTREDGRVILKIEKEEWKTLPS 77
Query: 559 AVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELD 618
+++ ++ LQ+ +H G L + + + NL L+L + IP + L LQEL
Sbjct: 78 SLLKLNQ-LQEWQLHRTGL-LKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELI 135
Query: 619 LKENNLKSI-EEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVLPS 677
L N +K++ +E+ + L KL + + I +P+ + L L L S N +P
Sbjct: 136 LSYNKIKTVPKELSNCASLEKLELAV--NRDICDLPQELSNLLKLTHLDLSMNDFTTIPL 193
Query: 678 HLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIG 737
+ + +LD+ N + +P I +Q+L + N++ LP + K L TL +
Sbjct: 194 AVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLS 253
Query: 738 KNSLS---VLSPKIGNLLFLSYLDVKGNHFEILPPELG 772
N L V ++ NL F+++ D LPP G
Sbjct: 254 NNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPPSEG 291
>gi|154091020 leucine-rich repeats and calponin homology (CH) domain
containing 2 [Homo sapiens]
Length = 765
Score = 80.9 bits (198), Expect = 4e-15
Identities = 56/168 (33%), Positives = 82/168 (48%), Gaps = 4/168 (2%)
Query: 601 LERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLT 660
L P + + L + DL N I V L L L+HN I IPE IK L
Sbjct: 100 LRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWL--FAPLETLNLYHNCIKTIPEAIKNLQ 157
Query: 661 SLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVES 720
L L+ S N + LP +LF ++ L +S N + IP EIG L+ L I+CN+++
Sbjct: 158 MLTYLNISRNLLSTLPKYLFDL-PLKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQV 216
Query: 721 LPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILP 768
LP ++ L+ L I +N+L VL ++G+L + LD N +P
Sbjct: 217 LPQQMGKLHSLRELNIRRNNLHVLPDELGDLPLVK-LDFSCNKVTEIP 263
Score = 65.9 bits (159), Expect = 1e-10
Identities = 43/142 (30%), Positives = 69/142 (48%), Gaps = 1/142 (0%)
Query: 641 VLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPP 700
+L L + P LT + S N+ +PS ++L + L+L +N I+ IP
Sbjct: 92 ILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPE 151
Query: 701 EIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVK 760
I LQ L Y +I+ N + +LP L F LK L + N L + +IG L L LD+
Sbjct: 152 AIKNLQMLTYLNISRNLLSTLPKYL-FDLPLKVLVVSNNKLVSIPEEIGKLKDLMELDIS 210
Query: 761 GNHFEILPPELGDCRALKRAGL 782
N ++LP ++G +L+ +
Sbjct: 211 CNEIQVLPQQMGKLHSLRELNI 232
Score = 55.5 bits (132), Expect = 2e-07
Identities = 52/193 (26%), Positives = 106/193 (54%), Gaps = 21/193 (10%)
Query: 505 ELPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRDLKSLKILSIKSNV-SKIPQAVVDV 563
E+P ++ LE L +L H+ + + E++++L+ L L+I N+ S +P+ + D+
Sbjct: 125 EIPSDVWLFAPLETL----NLYHNCIKTIP-EAIKNLQMLTYLNISRNLLSTLPKYLFDL 179
Query: 564 SSHLQKMCIHNDGTKLVML-NNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKEN 622
L+ + + N+ KLV + + K+ +L EL++ +++ +P + L SL+EL+++ N
Sbjct: 180 P--LKVLVVSNN--KLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRN 235
Query: 623 NLKSIEEIVSFQHLRKLTVLKLWH--NSITYIPEHIKKLTSLERLSFSHNKIEVLPSHLF 680
NL + + L L ++KL N +T IP +KL L+ + +N ++V P+ +
Sbjct: 236 NLHVLPD-----ELGDLPLVKLDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQIC 290
Query: 681 LCNKI---RYLDL 690
L K+ +YL++
Sbjct: 291 LKGKVHIFKYLNI 303
>gi|34577083 ras suppressor protein 1 isoform 2 [Homo sapiens]
Length = 224
Score = 80.5 bits (197), Expect = 6e-15
Identities = 52/150 (34%), Positives = 79/150 (52%), Gaps = 4/150 (2%)
Query: 604 IPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLE 663
+P + L +L+ L+ N ++ + +S L+KL L L N + +P L +LE
Sbjct: 2 VPPNIAELKNLEVLNFFNNQIEELPTQIS--SLQKLKHLNLGMNRLNTLPRGFGSLPALE 59
Query: 664 RLSFSHNKIEV--LPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESL 721
L ++N + LP + F +R L LS ND +PP+IG L LQ S+ N + SL
Sbjct: 60 VLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISL 119
Query: 722 PDELYFCKKLKTLKIGKNSLSVLSPKIGNL 751
P E+ +LK L I N L+VL P++GNL
Sbjct: 120 PKEIGELTQLKELHIQGNRLTVLPPELGNL 149
Score = 75.5 bits (184), Expect = 2e-13
Identities = 45/140 (32%), Positives = 71/140 (50%), Gaps = 2/140 (1%)
Query: 636 LRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDI 695
L+ L VL ++N I +P I L L+ L+ N++ LP + LDL+YN++
Sbjct: 9 LKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNL 68
Query: 696 --RFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLF 753
+P L +L+ ++ N E LP ++ KL+ L + N L L +IG L
Sbjct: 69 SENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQ 128
Query: 754 LSYLDVKGNHFEILPPELGD 773
L L ++GN +LPPELG+
Sbjct: 129 LKELHIQGNRLTVLPPELGN 148
Score = 55.8 bits (133), Expect = 2e-07
Identities = 38/121 (31%), Positives = 56/121 (46%)
Query: 585 LKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKL 644
+ + L L L L +P SL +L+ LDL NNL +F +L L L L
Sbjct: 29 ISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYL 88
Query: 645 WHNSITYIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGV 704
N +P I KLT L+ LS N + LP + +++ L + N + +PPE+G
Sbjct: 89 SDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGN 148
Query: 705 L 705
L
Sbjct: 149 L 149
Score = 52.0 bits (123), Expect = 2e-06
Identities = 36/126 (28%), Positives = 57/126 (45%), Gaps = 27/126 (21%)
Query: 698 IPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYL 757
+PP I L++L+ + N++E LP ++ +KLK L +G N L+ L G+L L L
Sbjct: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
Query: 758 D-------------------------VKGNHFEILPPELGDCRALKRAGLVVEDALFETL 792
D + N FEILPP++G L+ L D + +L
Sbjct: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLI--SL 119
Query: 793 PSDVRE 798
P ++ E
Sbjct: 120 PKEIGE 125
Score = 40.4 bits (93), Expect = 0.007
Identities = 41/175 (23%), Positives = 75/175 (42%), Gaps = 31/175 (17%)
Query: 506 LPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRDLKSLKILSIKSN-VSKIPQAVVDVS 564
+PP + L+NLE L + ++ ++ L+ LK L++ N ++ +P+ +
Sbjct: 2 VPPNIAELKNLEVLNFFNNQIEELPTQIS-----SLQKLKHLNLGMNRLNTLPRGFGSLP 56
Query: 565 SHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNL 624
+ +N+ ++ + N +T L L L D E +P + L LQ L L++N+L
Sbjct: 57 ALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDL 116
Query: 625 KSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVLPSHL 679
S +P+ I +LT L+ L N++ VLP L
Sbjct: 117 IS-------------------------LPKEIGELTQLKELHIQGNRLTVLPPEL 146
Score = 35.4 bits (80), Expect = 0.21
Identities = 48/211 (22%), Positives = 92/211 (43%), Gaps = 15/211 (7%)
Query: 458 MIPATIAQLDNLQELSLHQCSVKIHSAALSFLKENLKVLSVKFDDMRELPPWMYGLRNLE 517
M+P IA+L NL+ L+ ++ +S L + LK L++ + + LP G +L
Sbjct: 1 MVPPNIAELKNLEVLNFFNNQIEELPTQISSL-QKLKHLNLGMNRLNTLP---RGFGSLP 56
Query: 518 ELYLVGSLSHDISRNVTLESLRDLKSLKILSIKSNVSKIPQAVVDVSSHLQKMCIHNDGT 577
L ++ +++S N + L +L+ L + N +I + + LQ + + D
Sbjct: 57 ALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSL-RDND 115
Query: 578 KLVMLNNLKKMTNLTELELVHCDLERIPHAVFSL-LSLQELDLKENNLKSIEEIVS---- 632
+ + + ++T L EL + L +P + +L L+ Q+ K N + I
Sbjct: 116 LISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIADQFQL 175
Query: 633 -----FQHLRKLTVLKLWHNSITYIPEHIKK 658
F+++R T L+ + PE KK
Sbjct: 176 GVSHVFEYIRSETYKYLYGRHMQANPEPPKK 206
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,345,452
Number of Sequences: 37866
Number of extensions: 1234082
Number of successful extensions: 7663
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 110
Number of HSP's successfully gapped in prelim test: 146
Number of HSP's that attempted gapping in prelim test: 6114
Number of HSP's gapped (non-prelim): 782
length of query: 803
length of database: 18,247,518
effective HSP length: 110
effective length of query: 693
effective length of database: 14,082,258
effective search space: 9759004794
effective search space used: 9759004794
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.