Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 19923167
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|19923167 tubby isoform a [Homo sapiens]
(561 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|19923167 tubby isoform a [Homo sapiens] 1118 0.0
gi|29826279 tubby isoform b [Homo sapiens] 971 0.0
gi|21536436 tubby like protein 3 isoform 1 [Homo sapiens] 457 e-128
gi|238550202 tubby like protein 3 isoform 2 [Homo sapiens] 445 e-125
gi|157266334 tubby like protein 1 [Homo sapiens] 421 e-118
gi|238859545 tubby like protein 2 [Homo sapiens] 330 3e-90
gi|55953100 tubby like protein 4 isoform 1 [Homo sapiens] 78 2e-14
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 50 4e-06
gi|158854042 hypothetical protein LOC222183 [Homo sapiens] 49 1e-05
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof... 49 2e-05
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 48 2e-05
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 48 2e-05
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 48 2e-05
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ... 48 2e-05
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 48 3e-05
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f... 47 4e-05
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ... 47 4e-05
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 47 5e-05
gi|239743051 PREDICTED: hypothetical protein XP_002342747 [Homo ... 47 5e-05
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 46 1e-04
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof... 45 2e-04
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 45 2e-04
gi|55741677 SET domain containing 1A [Homo sapiens] 45 2e-04
gi|153070260 myristoylated alanine-rich protein kinase C substra... 44 5e-04
gi|21361272 myeloid/lymphoid or mixed-lineage leukemia (trithora... 43 9e-04
gi|156104889 myeloid/lymphoid or mixed-lineage leukemia (trithor... 42 0.001
gi|31377595 zinc finger CCCH-type containing 18 [Homo sapiens] 42 0.001
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 42 0.002
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ... 42 0.002
gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [... 42 0.002
>gi|19923167 tubby isoform a [Homo sapiens]
Length = 561
Score = 1118 bits (2893), Expect = 0.0
Identities = 561/561 (100%), Positives = 561/561 (100%)
Query: 1 MGARTPLPSFWVSFFAETGILFPGGTPWPMGSQHSKQHRKPGPLKRGHRRDRRTTRRKYW 60
MGARTPLPSFWVSFFAETGILFPGGTPWPMGSQHSKQHRKPGPLKRGHRRDRRTTRRKYW
Sbjct: 1 MGARTPLPSFWVSFFAETGILFPGGTPWPMGSQHSKQHRKPGPLKRGHRRDRRTTRRKYW 60
Query: 61 KEGREIARVLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSE 120
KEGREIARVLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSE
Sbjct: 61 KEGREIARVLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSE 120
Query: 121 EQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARK 180
EQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARK
Sbjct: 121 EQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARK 180
Query: 181 EKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATM 240
EKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATM
Sbjct: 181 EKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATM 240
Query: 241 QRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTAPEQPVD 300
QRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTAPEQPVD
Sbjct: 241 QRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTAPEQPVD 300
Query: 301 VEVQDLEEFALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLLAGRKRK 360
VEVQDLEEFALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLLAGRKRK
Sbjct: 301 VEVQDLEEFALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLLAGRKRK 360
Query: 361 KSKTSNYLISVDPTDLSRGGDSYIGKLRSNLMGTKFTVYDNGVNPQKASSSTLESGTLRQ 420
KSKTSNYLISVDPTDLSRGGDSYIGKLRSNLMGTKFTVYDNGVNPQKASSSTLESGTLRQ
Sbjct: 361 KSKTSNYLISVDPTDLSRGGDSYIGKLRSNLMGTKFTVYDNGVNPQKASSSTLESGTLRQ 420
Query: 421 ELAAVCYETNVLGFKGPRKMSVIVPGMNMVHERVSIRPRNEHETLLARWQNKNTESIIEL 480
ELAAVCYETNVLGFKGPRKMSVIVPGMNMVHERVSIRPRNEHETLLARWQNKNTESIIEL
Sbjct: 421 ELAAVCYETNVLGFKGPRKMSVIVPGMNMVHERVSIRPRNEHETLLARWQNKNTESIIEL 480
Query: 481 QNKTPVWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTMDYNYP 540
QNKTPVWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTMDYNYP
Sbjct: 481 QNKTPVWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTMDYNYP 540
Query: 541 LCALQAFAIALSSFDSKLACE 561
LCALQAFAIALSSFDSKLACE
Sbjct: 541 LCALQAFAIALSSFDSKLACE 561
>gi|29826279 tubby isoform b [Homo sapiens]
Length = 506
Score = 971 bits (2510), Expect = 0.0
Identities = 493/493 (100%), Positives = 493/493 (100%)
Query: 69 VLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVES 128
VLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVES
Sbjct: 14 VLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVES 73
Query: 129 YLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKG 188
YLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKG
Sbjct: 74 YLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKG 133
Query: 189 TSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSS 248
TSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSS
Sbjct: 134 TSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSS 193
Query: 249 MSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTAPEQPVDVEVQDLEE 308
MSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTAPEQPVDVEVQDLEE
Sbjct: 194 MSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTAPEQPVDVEVQDLEE 253
Query: 309 FALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLLAGRKRKKSKTSNYL 368
FALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLLAGRKRKKSKTSNYL
Sbjct: 254 FALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLLAGRKRKKSKTSNYL 313
Query: 369 ISVDPTDLSRGGDSYIGKLRSNLMGTKFTVYDNGVNPQKASSSTLESGTLRQELAAVCYE 428
ISVDPTDLSRGGDSYIGKLRSNLMGTKFTVYDNGVNPQKASSSTLESGTLRQELAAVCYE
Sbjct: 314 ISVDPTDLSRGGDSYIGKLRSNLMGTKFTVYDNGVNPQKASSSTLESGTLRQELAAVCYE 373
Query: 429 TNVLGFKGPRKMSVIVPGMNMVHERVSIRPRNEHETLLARWQNKNTESIIELQNKTPVWN 488
TNVLGFKGPRKMSVIVPGMNMVHERVSIRPRNEHETLLARWQNKNTESIIELQNKTPVWN
Sbjct: 374 TNVLGFKGPRKMSVIVPGMNMVHERVSIRPRNEHETLLARWQNKNTESIIELQNKTPVWN 433
Query: 489 DDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTMDYNYPLCALQAFA 548
DDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTMDYNYPLCALQAFA
Sbjct: 434 DDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTMDYNYPLCALQAFA 493
Query: 549 IALSSFDSKLACE 561
IALSSFDSKLACE
Sbjct: 494 IALSSFDSKLACE 506
>gi|21536436 tubby like protein 3 isoform 1 [Homo sapiens]
Length = 442
Score = 457 bits (1175), Expect = e-128
Identities = 250/496 (50%), Positives = 321/496 (64%), Gaps = 71/496 (14%)
Query: 69 VLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVES 128
V +E +RQ KLD QR LLE++Q+KKR EP MVQ N + R R + R S+EQ PLV
Sbjct: 15 VFHEEMMKMRQAKLDYQRLLLEKRQRKKRLEPFMVQPNPEARLRRAKPRASDEQTPLVNC 74
Query: 129 YLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKG 188
+ S + G
Sbjct: 75 HTPHSNVILH-------------------------------------------------G 85
Query: 189 TSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSS 248
GPAA+ + E P +V + D A++ +TA+ G L+ +Q+ IS S
Sbjct: 86 IDGPAAVLKP-DEVHAPSVSSSVVEED-AENTVDTASKPG-------LQERLQKHDISES 136
Query: 249 MSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTAPEQPVDV---EVQD 305
++FDE E + S S+ L RP+SA+S+ S S + A QP D ++ D
Sbjct: 137 VNFDE----ETDGISQSACLE---RPNSASSQNSTDTGTSGSATAA--QPADNLLGDIDD 187
Query: 306 LEEFALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLLAGRKRKKSKTS 365
LE+F PAPQG+T++CRI RDK+GMDRG++PTY+++L++E+ +K+FLLA RKRKKSKT+
Sbjct: 188 LEDFVYSPAPQGVTVRCRIIRDKRGMDRGLFPTYYMYLEKEENQKIFLLAARKRKKSKTA 247
Query: 366 NYLISVDPTDLSRGGDSYIGKLRSNLMGTKFTVYDNGVNPQKASSSTLESGTLRQELAAV 425
NYLIS+DP DLSR G+SY+GKLRSNLMGTKFTVYD G+ P K + T RQELAA+
Sbjct: 248 NYLISIDPVDLSREGESYVGKLRSNLMGTKFTVYDRGICPMKGRGLVGAAHT-RQELAAI 306
Query: 426 CYETNVLGFKGPRKMSVIVPGMNMVHERVSIRPRNEHETLLARWQNKNTESIIELQNKTP 485
YETNVLGFKGPRKMSVI+PGM + H+++ +P+N H++LL+RWQN+ E+++EL NK P
Sbjct: 307 SYETNVLGFKGPRKMSVIIPGMTLNHKQIPYQPQNNHDSLLSRWQNRTMENLVELHNKAP 366
Query: 486 VWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTMDYNYPLCALQ 545
VWN DTQSYVLNF GRVTQASVKNFQI+H NDPDYIVMQFGRVA+DVFT+DYNYPLCA+Q
Sbjct: 367 VWNSDTQSYVLNFRGRVTQASVKNFQIVHKNDPDYIVMQFGRVADDVFTLDYNYPLCAVQ 426
Query: 546 AFAIALSSFDSKLACE 561
AF I LSSFDSKLACE
Sbjct: 427 AFGIGLSSFDSKLACE 442
>gi|238550202 tubby like protein 3 isoform 2 [Homo sapiens]
Length = 501
Score = 445 bits (1144), Expect = e-125
Identities = 244/490 (49%), Positives = 315/490 (64%), Gaps = 71/490 (14%)
Query: 69 VLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVES 128
V +E +RQ KLD QR LLE++Q+KKR EP MVQ N + R R + R S+EQ PLV
Sbjct: 15 VFHEEMMKMRQAKLDYQRLLLEKRQRKKRLEPFMVQPNPEARLRRAKPRASDEQTPLVNC 74
Query: 129 YLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKG 188
+ S + G
Sbjct: 75 HTPHSNVILH-------------------------------------------------G 85
Query: 189 TSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSS 248
GPAA+ + E P +V + D A++ +TA+ G L+ +Q+ IS S
Sbjct: 86 IDGPAAVLKP-DEVHAPSVSSSVVEED-AENTVDTASKPG-------LQERLQKHDISES 136
Query: 249 MSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTAPEQPVDV---EVQD 305
++FDE E + S S+ L RP+SA+S+ S S + A QP D ++ D
Sbjct: 137 VNFDE----ETDGISQSACLE---RPNSASSQNSTDTGTSGSATAA--QPADNLLGDIDD 187
Query: 306 LEEFALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLLAGRKRKKSKTS 365
LE+F PAPQG+T++CRI RDK+GMDRG++PTY+++L++E+ +K+FLLA RKRKKSKT+
Sbjct: 188 LEDFVYSPAPQGVTVRCRIIRDKRGMDRGLFPTYYMYLEKEENQKIFLLAARKRKKSKTA 247
Query: 366 NYLISVDPTDLSRGGDSYIGKLRSNLMGTKFTVYDNGVNPQKASSSTLESGTLRQELAAV 425
NYLIS+DP DLSR G+SY+GKLRSNLMGTKFTVYD G+ P K + T RQELAA+
Sbjct: 248 NYLISIDPVDLSREGESYVGKLRSNLMGTKFTVYDRGICPMKGRGLVGAAHT-RQELAAI 306
Query: 426 CYETNVLGFKGPRKMSVIVPGMNMVHERVSIRPRNEHETLLARWQNKNTESIIELQNKTP 485
YETNVLGFKGPRKMSVI+PGM + H+++ +P+N H++LL+RWQN+ E+++EL NK P
Sbjct: 307 SYETNVLGFKGPRKMSVIIPGMTLNHKQIPYQPQNNHDSLLSRWQNRTMENLVELHNKAP 366
Query: 486 VWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTMDYNYPLCALQ 545
VWN DTQSYVLNF GRVTQASVKNFQI+H NDPDYIVMQFGRVA+DVFT+DYNYPLCA+Q
Sbjct: 367 VWNSDTQSYVLNFRGRVTQASVKNFQIVHKNDPDYIVMQFGRVADDVFTLDYNYPLCAVQ 426
Query: 546 AFAIALSSFD 555
AF I LSSFD
Sbjct: 427 AFGIGLSSFD 436
>gi|157266334 tubby like protein 1 [Homo sapiens]
Length = 542
Score = 421 bits (1083), Expect = e-118
Identities = 252/541 (46%), Positives = 321/541 (59%), Gaps = 70/541 (12%)
Query: 25 GTPWPMGSQHSKQHRKPGPLKRGHRRDRRTTRRKYWKEGREIARVLD--DEGRNLRQQKL 82
G P S Q R P + RD +R +E +AR D DE + +
Sbjct: 68 GRPREEPSPDPAQARAPQTVYARFLRDPEAKKRDP-RETFLVARAPDAEDEEEEEEEDEE 126
Query: 83 DRQRALLEQKQK--KKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQV 140
D + E+K+K ++PL +++AD + R +A Q P +
Sbjct: 127 DEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKA-----QGPRGD------------- 168
Query: 141 QEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKS 200
LG+ P P R + G+G RK KK K G + S
Sbjct: 169 ----------LGS--PDPPPKPLRVRNKEAPAGEGTKMRKTKK-KGSGEADKDPSGSPAS 215
Query: 201 EAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEE 260
+ P + VG+ G + +++KG ++EE+EEE
Sbjct: 216 ARKSPAAMFLVGE-------------------GSPDKKALKKKGTPKGAR--KEEEEEEE 254
Query: 261 NSSSSSQLNSNTRPSSATSRKSVREAASAPSPTAPEQPVDVEVQDLEEFALRPAPQGITI 320
++ + N + +K+ E A +P VEV + EF LRPAPQG T+
Sbjct: 255 AATVIKKSNQKGKAKGKGKKKAKEERAPSPP---------VEVDEPREFVLRPAPQGRTV 305
Query: 321 KCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLLAGRKRKKSKTSNYLISVDPTDLSRGG 380
+CR+TRDKKGMDRGMYP+YFLHLD E KKVFLLAGRKRK+SKT+NYLIS+DPT+LSRGG
Sbjct: 306 RCRLTRDKKGMDRGMYPSYFLHLDTE--KKVFLLAGRKRKRSKTANYLISIDPTNLSRGG 363
Query: 381 DSYIGKLRSNLMGTKFTVYDNGVNPQKASSSTLESGTLRQELAAVCYETNVLGFKGPRKM 440
+++IGKLRSNL+G +FTV+DNG NPQ+ S+ + S LRQELAAV YETNVLGF+GPR+M
Sbjct: 364 ENFIGKLRSNLLGNRFTVFDNGQNPQRGYSTNVAS--LRQELAAVIYETNVLGFRGPRRM 421
Query: 441 SVIVPGMNMVHERVSIRPRNEHETLLARWQNKNTESIIELQNKTPVWNDDTQSYVLNFHG 500
+VI+PGM+ +ERV IRPRN + LL RWQNK ES+IEL NK PVWNDD+ SY LNF G
Sbjct: 422 TVIIPGMSAENERVPIRPRNASDGLLVRWQNKTLESLIELHNKPPVWNDDSGSYTLNFQG 481
Query: 501 RVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTMDYNYPLCALQAFAIALSSFDSKLAC 560
RVTQASVKNFQI+H +DPDYIV+QFGRVAED FT+DY YPLCALQAFAIALSSFD KLAC
Sbjct: 482 RVTQASVKNFQIVHADDPDYIVLQFGRVAEDAFTLDYRYPLCALQAFAIALSSFDGKLAC 541
Query: 561 E 561
E
Sbjct: 542 E 542
>gi|238859545 tubby like protein 2 [Homo sapiens]
Length = 520
Score = 330 bits (845), Expect = 3e-90
Identities = 201/515 (39%), Positives = 287/515 (55%), Gaps = 34/515 (6%)
Query: 69 VLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQA----P 124
+L E +R QKL++QR L E+KQ++KRQE LMVQAN D P R+ EE+
Sbjct: 12 ILGHELAAMRLQKLEQQRRLFEKKQRQKRQELLMVQANPDASPWLWRSCLREERLLGDRG 71
Query: 125 LVESYLSSSGSTSYQVQEADS-LASVQLGAT-RPTAPASAKRTKAAATAGG--------- 173
L +L S ++ S L +V G R RT+A G
Sbjct: 72 LGNPFLRKKVSEAHLPSGIHSALGTVSCGGDGRGERGLPTPRTEAVFRNLGLQSPFLSWL 131
Query: 174 -QGGAARKEKKGKHKGTSGPAALAEDKS------EAQGPVQILTVGQSDHAQDAGETAAG 226
A E+ G+ P + +A G+SD +QD G+
Sbjct: 132 PDNSDAELEEVSVENGSVSPPPFKQSPRIRRKGWQAHQRPGTRAEGESD-SQDMGDAHKS 190
Query: 227 GGERPS-GQDLRATMQRKGISSSMSFDEDEEDEEENSSSSS-----QLNSNTRPSSATSR 280
P+ G D + ++ E E ++SS +L+ + T
Sbjct: 191 PNMGPNPGMDGDCVYENLAFQKEEDLEKKREASESTGTNSSAAHNEELSKALKGEGGTDS 250
Query: 281 KSVREAASAPSPTAPEQPVDVEVQDLEEFALRPAPQGITIKCRITRDKKGMDRGMYPTYF 340
+R AS A P +D+E + LRPA G ++C +TRDK G+D+G++P Y+
Sbjct: 251 DHMRHEASL----AIRSPCPGLEEDMEAYVLRPALPGTMMQCYLTRDKHGVDKGLFPLYY 306
Query: 341 LHLDREDGKKVFLLAGRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRSNLMGTKFTVYD 400
L+L+ D + FLLAGRKR++SKTSNYLIS+DPT LSR GD+++GK+RSN+ TKFT++D
Sbjct: 307 LYLETSDSLQRFLLAGRKRRRSKTSNYLISLDPTHLSRDGDNFVGKVRSNVFSTKFTIFD 366
Query: 401 NGVNPQKASSSTLESGTLRQELAAVCYETNVLGFKGPRKMSVIVPGMNMVHERVSIRPRN 460
NGVNP + T + +RQEL AVCYE NVLG+ GPRKM+VI+PG N ++R++++P N
Sbjct: 367 NGVNPDR-EHLTRNTARIRQELGAVCYEPNVLGYLGPRKMTVILPGTNSQNQRINVQPLN 425
Query: 461 EHETLLARWQNKNTESIIELQNKTPVWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDPDY 520
E E+LL+R+Q + + ++ L NKTP W+ + Y LNFHGRVT+ASVKNFQI+ ++
Sbjct: 426 EQESLLSRYQRGDKQGLLLLHNKTPSWDKENGVYTLNFHGRVTRASVKNFQIVDPKHQEH 485
Query: 521 IVMQFGRVAEDVFTMDYNYPLCALQAFAIALSSFD 555
+V+QFGRV D FTMD+ +P LQAF+I LSSF+
Sbjct: 486 LVLQFGRVGPDTFTMDFCFPFSPLQAFSICLSSFN 520
>gi|55953100 tubby like protein 4 isoform 1 [Homo sapiens]
Length = 1543
Score = 77.8 bits (190), Expect = 2e-14
Identities = 39/80 (48%), Positives = 53/80 (66%), Gaps = 5/80 (6%)
Query: 480 LQNKTPVWNDDTQSYVLNFHGRVTQASVKNFQI-IHGNDPDYIVMQFGRVAEDVFTMDYN 538
+ NK P+WN+ TQ Y L+F GRVTQ S KNFQI + G VMQFGR+ + +D+
Sbjct: 1467 MANKQPLWNEATQVYQLDFGGRVTQESAKNFQIELEGRQ----VMQFGRIDGSAYILDFQ 1522
Query: 539 YPLCALQAFAIALSSFDSKL 558
YP A+QAFA+AL++ +L
Sbjct: 1523 YPFSAVQAFAVALANVTQRL 1542
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 50.4 bits (119), Expect = 4e-06
Identities = 51/236 (21%), Positives = 90/236 (38%), Gaps = 34/236 (14%)
Query: 92 KQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASV-- 149
K +K + P+ V+A P+ RA S SSS S+S E + A+
Sbjct: 181 KNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPK 240
Query: 150 ------QLGATRPTAPASAKRTKAAATAGGQGGAARKEKK------GKHKGTSGPAALAE 197
Q+ A P A+ K++++ ++KK G + P+A
Sbjct: 241 KTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPP 300
Query: 198 DKSEAQGPVQILTVGQS--DHAQDAGETAAGGGERPSGQDLRATMQR------------K 243
KS P + Q + ++D+ + + E +A + + +
Sbjct: 301 KKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAE 360
Query: 244 GISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTAPEQPV 299
S S D E+DE + + + NS+ +P+ T +V+ AA AP+QPV
Sbjct: 361 SSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAA------APKQPV 410
Score = 44.7 bits (104), Expect = 2e-04
Identities = 51/237 (21%), Positives = 91/237 (38%), Gaps = 21/237 (8%)
Query: 74 GRNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLV--ESYLS 131
G+ L +K D + E ++ + MV +QAP +S
Sbjct: 413 GQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSD 472
Query: 132 SSGSTSYQVQEADSLASVQ------LGATRPTAPASAKRTKAAATAGGQGGAARKEKKGK 185
S S+S + +E S ++V+ G P+ PASAK+ KA ++ + +E++ K
Sbjct: 473 SDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEK 532
Query: 186 HKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGI 245
KG P A + G S G+ A E + A + K
Sbjct: 533 LKGKGSPRPQAPKAN-----------GTSALTAQNGKAAKNSEEEEEEKKKAAVVVSK-- 579
Query: 246 SSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTAPEQPVDVE 302
S S+ + E +E + ++ P++ RK + AS+P E+ ++V+
Sbjct: 580 SGSLKKRKQNEAAKEAETPQAKKIKLQTPNTFPKRKKGEKRASSPFRRVREEEIEVD 636
Score = 32.0 bits (71), Expect = 1.5
Identities = 49/238 (20%), Positives = 93/238 (39%), Gaps = 34/238 (14%)
Query: 85 QRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLV--------------ESYL 130
+++L Q KK ++ V+++ D S + + E++ P ++
Sbjct: 301 KKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAE 360
Query: 131 SSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTS 190
SSS S+ E D S G T+ ++ A TK+ A + AA K+ G
Sbjct: 361 SSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAV---KPAAAPKQPVG------ 411
Query: 191 GPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGI--SSS 248
G L K+++ + + + + + T + L A +G SSS
Sbjct: 412 GGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSS 471
Query: 249 MSFDEDEEDEEENSSSSSQLN---------SNTRPSSATSRKSVREAASAPSPTAPEQ 297
S E+EEE +S S+ + ++P+SA K+ +S+ ++ E+
Sbjct: 472 DSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEE 529
>gi|158854042 hypothetical protein LOC222183 [Homo sapiens]
Length = 653
Score = 48.9 bits (115), Expect = 1e-05
Identities = 67/288 (23%), Positives = 102/288 (35%), Gaps = 49/288 (17%)
Query: 32 SQHSKQHRKPGPLKRGHRRDRRTTR-------------RKYWKEGREIARVLDDEGRNLR 78
S S +K K GHRR R+ R RK K ++ R D G R
Sbjct: 162 SSASPPPKKKKKKKGGHRRSRKKRRLESECSCGSSSPLRKKKKSVKKHRRDRSDSGS--R 219
Query: 79 QQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSY 138
+++ R R+ + K+K+K +E + GR RS R +P + S+ S S S S
Sbjct: 220 RKRRHRSRSS-KCKRKEKNKEKKRPHTESPGR-RSHRHSSGSSHSPSLSSHYSDSRSPSR 277
Query: 139 ----QVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSG--- 191
E S + +R +P+ + GG G ++ G H G G
Sbjct: 278 LSPKHRDEGRKTGSQRSSGSRSPSPSGGSGWGSPQRNGGSG-----QRSGAHGGRPGSAH 332
Query: 192 --------PAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRK 243
P+ DK+ A P +S + A + GG G R +R+
Sbjct: 333 SPPDKPSSPSPRVRDKAAAAAPTPPARGKESPSPRSAPSSQGRGGRAAGGAGRRRRRRRR 392
Query: 244 GISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPS 291
+S+S+ + RP A R S R + A S
Sbjct: 393 ------------RRRSRSSASAPRRRGRRRPRPAPPRGSSRSLSRARS 428
Score = 33.9 bits (76), Expect = 0.41
Identities = 54/234 (23%), Positives = 89/234 (38%), Gaps = 41/234 (17%)
Query: 75 RNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSG 134
R R + A K+KKK++ G RSR+ R+ E + S G
Sbjct: 152 RGYRTKHWSSSSASPPPKKKKKKK---------GGHRRSRKKRRLESEC--------SCG 194
Query: 135 STSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKH-------- 186
S+S ++ S+ + R + + KR + ++ + KEKK H
Sbjct: 195 SSSPLRKKKKSVKKHR--RDRSDSGSRRKRRHRSRSSKCKRKEKNKEKKRPHTESPGRRS 252
Query: 187 ----KGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPS--GQDLRATM 240
G+S +L+ S+++ P + L+ D + G + G PS G +
Sbjct: 253 HRHSSGSSHSPSLSSHYSDSRSPSR-LSPKHRDEGRKTGSQRSSGSRSPSPSGGSGWGSP 311
Query: 241 QRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTA 294
QR G S S S + +PSS + R + AA+AP+P A
Sbjct: 312 QRNGGSGQRS-------GAHGGRPGSAHSPPDKPSSPSPRVRDKAAAAAPTPPA 358
>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
4 [Homo sapiens]
Length = 737
Score = 48.5 bits (114), Expect = 2e-05
Identities = 57/267 (21%), Positives = 103/267 (38%), Gaps = 32/267 (11%)
Query: 27 PWPMGSQHSKQHRKPGPLK-----RGHRRDRRTTRRKYWKEGREIARVLDD--EGRNLRQ 79
P M + HRK K R ++R RRK +E ++ AR + + R + +
Sbjct: 54 PQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAR 113
Query: 80 QKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLS-SSGSTSY 138
+ R+R LEQ ++K+ +E M + + R + R R++EE+ E+ S+ +
Sbjct: 114 EHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTM 173
Query: 139 QVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAALAED 198
+ +D + + + P P G G KE+K + + L D
Sbjct: 174 REDYSDKVKASHWSRSPPRPPRERFEL-------GDGRKPVKEEKMEERD------LLSD 220
Query: 199 KSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDE 258
+ SD + + E SG + + + + +E EE+E
Sbjct: 221 LQDI-----------SDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEE 269
Query: 259 EENSSSSSQLNSNTRPSSATSRKSVRE 285
EE + SN+ +S S + V E
Sbjct: 270 EEEEEEEEETGSNSEEASEQSAEEVSE 296
Score = 43.1 bits (100), Expect = 7e-04
Identities = 67/364 (18%), Positives = 138/364 (37%), Gaps = 64/364 (17%)
Query: 36 KQHRKPGPLKRGHRRDRRTTRRKYWKEGR-EIARVLDDEGRNLRQQ---KLDRQRALLEQ 91
K+ + ++ HR ++ RR++ ++ R E+AR R+ +Q K +R+R + EQ
Sbjct: 80 KEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQ 139
Query: 92 KQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSY------------- 138
+++++ Q+ +A + R R S + E Y ++ +
Sbjct: 140 QKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFE 199
Query: 139 -----------QVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHK 187
+++E D L+ +Q S ++T +A ++ + G+ +E++ +
Sbjct: 200 LGDGRKPVKEEKMEERDLLSDLQ------DISDSERKTSSAESSSAESGSGSEEEEEE-- 251
Query: 188 GTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISS 247
E++ E +G + + + ++ E E S Q + +
Sbjct: 252 ---------EEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEE---- 298
Query: 248 SMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTA-------PEQPVD 300
EDEE E EN + R S + P +A P+ P
Sbjct: 299 ---MSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPAL 355
Query: 301 VEVQDLEEF-ALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLLAGRKR 359
++ +E PA QG CR + + ++R TY + +D K ++A ++
Sbjct: 356 SPIELKQELPKYLPALQG----CRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRL 411
Query: 360 KKSK 363
K K
Sbjct: 412 KMEK 415
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 48.1 bits (113), Expect = 2e-05
Identities = 57/223 (25%), Positives = 88/223 (39%), Gaps = 28/223 (12%)
Query: 104 QANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQ-----LGATRPTA 158
Q P ++RA++ EE ES S GS S + A + + V+ L +A
Sbjct: 251 QVKGGALPPAKRAKKPEE-----ESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASA 305
Query: 159 PASAKRTKAAATA--GGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQ--ILTVGQS 214
PA K A A G G A + K GK + S ++ SE + P +L S
Sbjct: 306 PAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKAS 365
Query: 215 DHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSF----DEDEEDEEENSSSSSQLNS 270
G +A E P A + G + + + +ED + E S S + +
Sbjct: 366 GKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPA 425
Query: 271 NTRPS---------SATSRKSVREAASAPSPTAPEQPVDVEVQ 304
+PS SA +++S R+ A AP+P P +VQ
Sbjct: 426 QAKPSGKAPQVRAASAPAKESPRKGA-APAPPRKTGPAAAQVQ 467
Score = 45.8 bits (107), Expect = 1e-04
Identities = 46/185 (24%), Positives = 79/185 (42%), Gaps = 20/185 (10%)
Query: 108 DGRPRSRRARQSEEQAPLVESYLSS--SGSTSYQVQEADSLASVQLGATRPTAPASAKRT 165
D S + SEE+ P ++ L + SG TS Q+GA A S ++
Sbjct: 338 DSESSSEESSDSEEETPAAKALLQAKASGKTS------------QVGAASAPAKESPRKG 385
Query: 166 KAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAA 225
A A G G A K + GK + S ++ E SE + P Q G++ + A +A
Sbjct: 386 AAPAPPGKTGPAVAKAQAGKREEDS-QSSSEESDSEEEAPAQAKPSGKAPQVRAA---SA 441
Query: 226 GGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVRE 285
E P A ++ G +++ + + EE++ SSS + +S+ +A + V+
Sbjct: 442 PAKESPRKGAAPAPPRKTGPAAAQV--QVGKQEEDSRSSSEESDSDREALAAMNAAQVKP 499
Query: 286 AASAP 290
+P
Sbjct: 500 LGKSP 504
Score = 39.7 bits (91), Expect = 0.007
Identities = 45/207 (21%), Positives = 78/207 (37%), Gaps = 14/207 (6%)
Query: 105 ANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKR 164
A A R ++ S E++ E + + + Q + A + + APA ++
Sbjct: 399 AKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRK 458
Query: 165 TKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDA---- 220
T AA G + + S ALA A Q+ +G+S + A
Sbjct: 459 TGPAAAQVQVGKQEEDSRSSSEESDSDREALA-----AMNAAQVKPLGKSPQVKPASTMG 513
Query: 221 -GETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATS 279
G G G P G+ AT + D + EE + SS ++ + P+ S
Sbjct: 514 MGPLGKGAGPVPPGKVGPATPSAQ--VGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKS 571
Query: 280 RKSVREA--ASAPSPTAPEQPVDVEVQ 304
++ +A S+P+ P++ V VQ
Sbjct: 572 LGNILQAKPTSSPAKGPPQKAGPVAVQ 598
Score = 39.3 bits (90), Expect = 0.010
Identities = 51/240 (21%), Positives = 92/240 (38%), Gaps = 34/240 (14%)
Query: 92 KQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQL 151
K ++ P+ VQ A+ +P + SEE + +S + + T+ Q + A + +
Sbjct: 586 KGPPQKAGPVAVQVKAE-KPMDN-SESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKA 643
Query: 152 GATRPTAPASAK---------RTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEA 202
+ ASAK + A TA G++ G + ++ E SE
Sbjct: 644 CPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 703
Query: 203 QGPVQILTVGQSDHAQDAGETAAG-----------------GGERPSGQDLRATMQRKGI 245
+ +TVGQ+ + A G P+ ++A Q
Sbjct: 704 EKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSE 763
Query: 246 SSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSP-TAPEQPVDVEVQ 304
SS E+E D EE ++S +Q+ ++ + + A + + A SA +AP + V Q
Sbjct: 764 SS-----EEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQ 818
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 48.1 bits (113), Expect = 2e-05
Identities = 57/223 (25%), Positives = 88/223 (39%), Gaps = 28/223 (12%)
Query: 104 QANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQ-----LGATRPTA 158
Q P ++RA++ EE ES S GS S + A + + V+ L +A
Sbjct: 251 QVKGGALPPAKRAKKPEE-----ESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASA 305
Query: 159 PASAKRTKAAATA--GGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQ--ILTVGQS 214
PA K A A G G A + K GK + S ++ SE + P +L S
Sbjct: 306 PAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKAS 365
Query: 215 DHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSF----DEDEEDEEENSSSSSQLNS 270
G +A E P A + G + + + +ED + E S S + +
Sbjct: 366 GKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPA 425
Query: 271 NTRPS---------SATSRKSVREAASAPSPTAPEQPVDVEVQ 304
+PS SA +++S R+ A AP+P P +VQ
Sbjct: 426 QAKPSGKAPQVRAASAPAKESPRKGA-APAPPRKTGPAAAQVQ 467
Score = 45.8 bits (107), Expect = 1e-04
Identities = 46/185 (24%), Positives = 79/185 (42%), Gaps = 20/185 (10%)
Query: 108 DGRPRSRRARQSEEQAPLVESYLSS--SGSTSYQVQEADSLASVQLGATRPTAPASAKRT 165
D S + SEE+ P ++ L + SG TS Q+GA A S ++
Sbjct: 338 DSESSSEESSDSEEETPAAKALLQAKASGKTS------------QVGAASAPAKESPRKG 385
Query: 166 KAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAA 225
A A G G A K + GK + S ++ E SE + P Q G++ + A +A
Sbjct: 386 AAPAPPGKTGPAVAKAQAGKREEDS-QSSSEESDSEEEAPAQAKPSGKAPQVRAA---SA 441
Query: 226 GGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVRE 285
E P A ++ G +++ + + EE++ SSS + +S+ +A + V+
Sbjct: 442 PAKESPRKGAAPAPPRKTGPAAAQV--QVGKQEEDSRSSSEESDSDREALAAMNAAQVKP 499
Query: 286 AASAP 290
+P
Sbjct: 500 LGKSP 504
Score = 39.7 bits (91), Expect = 0.007
Identities = 45/207 (21%), Positives = 78/207 (37%), Gaps = 14/207 (6%)
Query: 105 ANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKR 164
A A R ++ S E++ E + + + Q + A + + APA ++
Sbjct: 399 AKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRK 458
Query: 165 TKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDA---- 220
T AA G + + S ALA A Q+ +G+S + A
Sbjct: 459 TGPAAAQVQVGKQEEDSRSSSEESDSDREALA-----AMNAAQVKPLGKSPQVKPASTMG 513
Query: 221 -GETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATS 279
G G G P G+ AT + D + EE + SS ++ + P+ S
Sbjct: 514 MGPLGKGAGPVPPGKVGPATPSAQ--VGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKS 571
Query: 280 RKSVREA--ASAPSPTAPEQPVDVEVQ 304
++ +A S+P+ P++ V VQ
Sbjct: 572 LGNILQAKPTSSPAKGPPQKAGPVAVQ 598
Score = 39.3 bits (90), Expect = 0.010
Identities = 51/240 (21%), Positives = 92/240 (38%), Gaps = 34/240 (14%)
Query: 92 KQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQL 151
K ++ P+ VQ A+ +P + SEE + +S + + T+ Q + A + +
Sbjct: 586 KGPPQKAGPVAVQVKAE-KPMDN-SESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKA 643
Query: 152 GATRPTAPASAK---------RTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEA 202
+ ASAK + A TA G++ G + ++ E SE
Sbjct: 644 CPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 703
Query: 203 QGPVQILTVGQSDHAQDAGETAAG-----------------GGERPSGQDLRATMQRKGI 245
+ +TVGQ+ + A G P+ ++A Q
Sbjct: 704 EKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSE 763
Query: 246 SSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSP-TAPEQPVDVEVQ 304
SS E+E D EE ++S +Q+ ++ + + A + + A SA +AP + V Q
Sbjct: 764 SS-----EEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQ 818
Score = 35.8 bits (81), Expect = 0.11
Identities = 47/212 (22%), Positives = 71/212 (33%), Gaps = 31/212 (14%)
Query: 104 QANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAK 163
QA A PR RA +S ++ SSS S V A + + T P +
Sbjct: 977 QAQAASTPRKARASESTARS-------SSSESEDEDVIPATQCLTPGIRTNVVTMPTAHP 1029
Query: 164 RTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEA-----QGPVQILTVGQSD--- 215
R A+ G + + K GPA K+ A Q +++L S+
Sbjct: 1030 RIAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQP 1089
Query: 216 ---HAQDAGETAAGGGERPSGQDLRATMQRKG-----------ISSSMSFDEDEEDEEEN 261
Q + + G P+ ++Q KG + + E +D E++
Sbjct: 1090 PVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDS 1149
Query: 262 SSSSSQLNSNTRPSSATSRKSVREAASAPSPT 293
S SSS S KS PS T
Sbjct: 1150 SDSSS--GSEEDGEGPQGAKSAHTLGPTPSRT 1179
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
[Homo sapiens]
Length = 1450
Score = 48.1 bits (113), Expect = 2e-05
Identities = 57/223 (25%), Positives = 88/223 (39%), Gaps = 28/223 (12%)
Query: 104 QANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQ-----LGATRPTA 158
Q P ++RA++ EE ES S GS S + A + + V+ L +A
Sbjct: 251 QVKGGALPPAKRAKKPEE-----ESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASA 305
Query: 159 PASAKRTKAAATA--GGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQ--ILTVGQS 214
PA K A A G G A + K GK + S ++ SE + P +L S
Sbjct: 306 PAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKAS 365
Query: 215 DHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSF----DEDEEDEEENSSSSSQLNS 270
G +A E P A + G + + + +ED + E S S + +
Sbjct: 366 GKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPA 425
Query: 271 NTRPS---------SATSRKSVREAASAPSPTAPEQPVDVEVQ 304
+PS SA +++S R+ A AP+P P +VQ
Sbjct: 426 QAKPSGKAPQVRAASAPAKESPRKGA-APAPPRKTGPAAAQVQ 467
Score = 45.8 bits (107), Expect = 1e-04
Identities = 46/185 (24%), Positives = 79/185 (42%), Gaps = 20/185 (10%)
Query: 108 DGRPRSRRARQSEEQAPLVESYLSS--SGSTSYQVQEADSLASVQLGATRPTAPASAKRT 165
D S + SEE+ P ++ L + SG TS Q+GA A S ++
Sbjct: 338 DSESSSEESSDSEEETPAAKALLQAKASGKTS------------QVGAASAPAKESPRKG 385
Query: 166 KAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAA 225
A A G G A K + GK + S ++ E SE + P Q G++ + A +A
Sbjct: 386 AAPAPPGKTGPAVAKAQAGKREEDS-QSSSEESDSEEEAPAQAKPSGKAPQVRAA---SA 441
Query: 226 GGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVRE 285
E P A ++ G +++ + + EE++ SSS + +S+ +A + V+
Sbjct: 442 PAKESPRKGAAPAPPRKTGPAAAQV--QVGKQEEDSRSSSEESDSDREALAAMNAAQVKP 499
Query: 286 AASAP 290
+P
Sbjct: 500 LGKSP 504
Score = 39.7 bits (91), Expect = 0.007
Identities = 45/207 (21%), Positives = 78/207 (37%), Gaps = 14/207 (6%)
Query: 105 ANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKR 164
A A R ++ S E++ E + + + Q + A + + APA ++
Sbjct: 399 AKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRK 458
Query: 165 TKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDA---- 220
T AA G + + S ALA A Q+ +G+S + A
Sbjct: 459 TGPAAAQVQVGKQEEDSRSSSEESDSDREALA-----AMNAAQVKPLGKSPQVKPASTMG 513
Query: 221 -GETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATS 279
G G G P G+ AT + D + EE + SS ++ + P+ S
Sbjct: 514 MGPLGKGAGPVPPGKVGPATPSAQ--VGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKS 571
Query: 280 RKSVREA--ASAPSPTAPEQPVDVEVQ 304
++ +A S+P+ P++ V VQ
Sbjct: 572 LGNILQAKPTSSPAKGPPQKAGPVAVQ 598
Score = 39.3 bits (90), Expect = 0.010
Identities = 51/240 (21%), Positives = 92/240 (38%), Gaps = 34/240 (14%)
Query: 92 KQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQL 151
K ++ P+ VQ A+ +P + SEE + +S + + T+ Q + A + +
Sbjct: 586 KGPPQKAGPVAVQVKAE-KPMDN-SESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKA 643
Query: 152 GATRPTAPASAK---------RTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEA 202
+ ASAK + A TA G++ G + ++ E SE
Sbjct: 644 CPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 703
Query: 203 QGPVQILTVGQSDHAQDAGETAAG-----------------GGERPSGQDLRATMQRKGI 245
+ +TVGQ+ + A G P+ ++A Q
Sbjct: 704 EKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSE 763
Query: 246 SSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSP-TAPEQPVDVEVQ 304
SS E+E D EE ++S +Q+ ++ + + A + + A SA +AP + V Q
Sbjct: 764 SS-----EEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQ 818
>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
[Homo sapiens]
Length = 958
Score = 48.1 bits (113), Expect = 2e-05
Identities = 57/223 (25%), Positives = 88/223 (39%), Gaps = 28/223 (12%)
Query: 104 QANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQ-----LGATRPTA 158
Q P ++RA++ EE ES S GS S + A + + V+ L +A
Sbjct: 251 QVKGGALPPAKRAKKPEE-----ESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASA 305
Query: 159 PASAKRTKAAATA--GGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQ--ILTVGQS 214
PA K A A G G A + K GK + S ++ SE + P +L S
Sbjct: 306 PAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKAS 365
Query: 215 DHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSF----DEDEEDEEENSSSSSQLNS 270
G +A E P A + G + + + +ED + E S S + +
Sbjct: 366 GKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPA 425
Query: 271 NTRPS---------SATSRKSVREAASAPSPTAPEQPVDVEVQ 304
+PS SA +++S R+ A AP+P P +VQ
Sbjct: 426 QAKPSGKAPQVRAASAPAKESPRKGA-APAPPRKTGPAAAQVQ 467
Score = 45.8 bits (107), Expect = 1e-04
Identities = 46/185 (24%), Positives = 79/185 (42%), Gaps = 20/185 (10%)
Query: 108 DGRPRSRRARQSEEQAPLVESYLSS--SGSTSYQVQEADSLASVQLGATRPTAPASAKRT 165
D S + SEE+ P ++ L + SG TS Q+GA A S ++
Sbjct: 338 DSESSSEESSDSEEETPAAKALLQAKASGKTS------------QVGAASAPAKESPRKG 385
Query: 166 KAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAA 225
A A G G A K + GK + S ++ E SE + P Q G++ + A +A
Sbjct: 386 AAPAPPGKTGPAVAKAQAGKREEDS-QSSSEESDSEEEAPAQAKPSGKAPQVRAA---SA 441
Query: 226 GGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVRE 285
E P A ++ G +++ + + EE++ SSS + +S+ +A + V+
Sbjct: 442 PAKESPRKGAAPAPPRKTGPAAAQV--QVGKQEEDSRSSSEESDSDREALAAMNAAQVKP 499
Query: 286 AASAP 290
+P
Sbjct: 500 LGKSP 504
Score = 39.7 bits (91), Expect = 0.007
Identities = 45/207 (21%), Positives = 78/207 (37%), Gaps = 14/207 (6%)
Query: 105 ANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKR 164
A A R ++ S E++ E + + + Q + A + + APA ++
Sbjct: 399 AKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRK 458
Query: 165 TKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDA---- 220
T AA G + + S ALA A Q+ +G+S + A
Sbjct: 459 TGPAAAQVQVGKQEEDSRSSSEESDSDREALA-----AMNAAQVKPLGKSPQVKPASTMG 513
Query: 221 -GETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATS 279
G G G P G+ AT + D + EE + SS ++ + P+ S
Sbjct: 514 MGPLGKGAGPVPPGKVGPATPSAQ--VGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKS 571
Query: 280 RKSVREA--ASAPSPTAPEQPVDVEVQ 304
++ +A S+P+ P++ V VQ
Sbjct: 572 LGNILQAKPTSSPAKGPPQKAGPVAVQ 598
Score = 39.3 bits (90), Expect = 0.010
Identities = 51/240 (21%), Positives = 92/240 (38%), Gaps = 34/240 (14%)
Query: 92 KQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQL 151
K ++ P+ VQ A+ +P + SEE + +S + + T+ Q + A + +
Sbjct: 586 KGPPQKAGPVAVQVKAE-KPMDN-SESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKA 643
Query: 152 GATRPTAPASAK---------RTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEA 202
+ ASAK + A TA G++ G + ++ E SE
Sbjct: 644 CPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 703
Query: 203 QGPVQILTVGQSDHAQDAGETAAG-----------------GGERPSGQDLRATMQRKGI 245
+ +TVGQ+ + A G P+ ++A Q
Sbjct: 704 EKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSE 763
Query: 246 SSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSP-TAPEQPVDVEVQ 304
SS E+E D EE ++S +Q+ ++ + + A + + A SA +AP + V Q
Sbjct: 764 SS-----EEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQ 818
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 47.8 bits (112), Expect = 3e-05
Identities = 68/369 (18%), Positives = 142/369 (38%), Gaps = 64/369 (17%)
Query: 31 GSQHSKQHRKPGPLKRGHRRDRRTTRRKYWKEGR-EIARVLDDEGRNLRQQ---KLDRQR 86
G +H++ + ++ HR ++ RR++ ++ R E+AR R+ +Q K +R+R
Sbjct: 118 GGKHARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERER 177
Query: 87 ALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSY-------- 138
+ EQ+++++ Q+ +A + R R S + E Y ++ +
Sbjct: 178 KMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPP 237
Query: 139 ----------------QVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEK 182
+++E D L+ +Q S ++T +A ++ + G+ +E+
Sbjct: 238 RERFELGDGRKPVKEEKMEERDLLSDLQ------DISDSERKTSSAESSSAESGSGSEEE 291
Query: 183 KGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQR 242
+ + E++ E +G + + + ++ E E S Q +
Sbjct: 292 EEE-----------EEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEE 340
Query: 243 KGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTA-------P 295
+ EDEE E EN + R S + P +A P
Sbjct: 341 E-------MSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVP 393
Query: 296 EQPVDVEVQDLEEF-ALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLL 354
+ P + ++ +E PA QG CR + + ++R TY + +D K ++
Sbjct: 394 DSPALLPIELKQELPKYLPALQG----CRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIV 449
Query: 355 AGRKRKKSK 363
A ++ K K
Sbjct: 450 ALKRLKMEK 458
>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
[Homo sapiens]
Length = 1412
Score = 47.4 bits (111), Expect = 4e-05
Identities = 60/259 (23%), Positives = 101/259 (38%), Gaps = 30/259 (11%)
Query: 63 GREIARVLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQ 122
G+ +A +L G++ R+ L + +++ P A G + +A S E
Sbjct: 145 GKTVANLLS--GKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSED 202
Query: 123 APLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATA--GGQGGAARK 180
SSS T +V+ ++ + V+ + APA K A A G G A +
Sbjct: 203 TS------SSSDETDVEVKASEKILQVRAAS----APAKGTPGKGATPAPPGKAGAVASQ 252
Query: 181 EKKGKHKGTSGPAALAEDKSEAQGPVQ--ILTVGQSDHAQDAGETAAGGGERPSGQDLRA 238
K GK + S ++ SE + P +L S G +A E P A
Sbjct: 253 TKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPA 312
Query: 239 TMQRKGISSSMSF----DEDEEDEEENSSSSSQLNSNTRPS---------SATSRKSVRE 285
+ G + + + +ED + E S S + + +PS SA +++S R+
Sbjct: 313 PPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRK 372
Query: 286 AASAPSPTAPEQPVDVEVQ 304
A AP+P P +VQ
Sbjct: 373 GA-APAPPRKTGPAAAQVQ 390
Score = 45.8 bits (107), Expect = 1e-04
Identities = 46/185 (24%), Positives = 79/185 (42%), Gaps = 20/185 (10%)
Query: 108 DGRPRSRRARQSEEQAPLVESYLSS--SGSTSYQVQEADSLASVQLGATRPTAPASAKRT 165
D S + SEE+ P ++ L + SG TS Q+GA A S ++
Sbjct: 261 DSESSSEESSDSEEETPAAKALLQAKASGKTS------------QVGAASAPAKESPRKG 308
Query: 166 KAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAA 225
A A G G A K + GK + S ++ E SE + P Q G++ + A +A
Sbjct: 309 AAPAPPGKTGPAVAKAQAGKREEDS-QSSSEESDSEEEAPAQAKPSGKAPQVRAA---SA 364
Query: 226 GGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVRE 285
E P A ++ G +++ + + EE++ SSS + +S+ +A + V+
Sbjct: 365 PAKESPRKGAAPAPPRKTGPAAAQV--QVGKQEEDSRSSSEESDSDREALAAMNAAQVKP 422
Query: 286 AASAP 290
+P
Sbjct: 423 LGKSP 427
Score = 39.7 bits (91), Expect = 0.007
Identities = 45/207 (21%), Positives = 78/207 (37%), Gaps = 14/207 (6%)
Query: 105 ANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKR 164
A A R ++ S E++ E + + + Q + A + + APA ++
Sbjct: 322 AKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRK 381
Query: 165 TKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDA---- 220
T AA G + + S ALA A Q+ +G+S + A
Sbjct: 382 TGPAAAQVQVGKQEEDSRSSSEESDSDREALA-----AMNAAQVKPLGKSPQVKPASTMG 436
Query: 221 -GETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATS 279
G G G P G+ AT + D + EE + SS ++ + P+ S
Sbjct: 437 MGPLGKGAGPVPPGKVGPATPSAQ--VGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKS 494
Query: 280 RKSVREA--ASAPSPTAPEQPVDVEVQ 304
++ +A S+P+ P++ V VQ
Sbjct: 495 LGNILQAKPTSSPAKGPPQKAGPVAVQ 521
Score = 39.3 bits (90), Expect = 0.010
Identities = 51/240 (21%), Positives = 92/240 (38%), Gaps = 34/240 (14%)
Query: 92 KQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQL 151
K ++ P+ VQ A+ +P + SEE + +S + + T+ Q + A + +
Sbjct: 509 KGPPQKAGPVAVQVKAE-KPMDN-SESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKA 566
Query: 152 GATRPTAPASAK---------RTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEA 202
+ ASAK + A TA G++ G + ++ E SE
Sbjct: 567 CPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 626
Query: 203 QGPVQILTVGQSDHAQDAGETAAG-----------------GGERPSGQDLRATMQRKGI 245
+ +TVGQ+ + A G P+ ++A Q
Sbjct: 627 EKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSE 686
Query: 246 SSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSP-TAPEQPVDVEVQ 304
SS E+E D EE ++S +Q+ ++ + + A + + A SA +AP + V Q
Sbjct: 687 SS-----EEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQ 741
Score = 35.4 bits (80), Expect = 0.14
Identities = 49/228 (21%), Positives = 80/228 (35%), Gaps = 34/228 (14%)
Query: 104 QANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAK 163
QA A PR RA +S ++ SSS S V A + + T P +
Sbjct: 900 QAQAASTPRKARASESTARS-------SSSESEDEDVIPATQCLTPGIRTNVVTMPTAHP 952
Query: 164 RTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEA-----QGPVQILTVGQSD--- 215
R A+ G + + K GPA K+ A Q +++L S+
Sbjct: 953 RIAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQP 1012
Query: 216 ---HAQDAGETAAGGGERPSGQDLRATMQRKG-----------ISSSMSFDEDEEDEEEN 261
Q + + G P+ ++Q KG + + E +D E++
Sbjct: 1013 PVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDS 1072
Query: 262 SSSSSQLNSNTR-PSSATSRKSVREAASAPSPTAPEQPVDVEVQDLEE 308
S SSS + P A S ++ P+P+ E V+ + E
Sbjct: 1073 SDSSSGSEEDGEGPQGAKSAHTL----VGPTPSRTETLVEETAAESSE 1116
>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b
[Homo sapiens]
Length = 1411
Score = 47.4 bits (111), Expect = 4e-05
Identities = 60/259 (23%), Positives = 101/259 (38%), Gaps = 30/259 (11%)
Query: 63 GREIARVLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQ 122
G+ +A +L G++ R+ L + +++ P A G + +A S E
Sbjct: 145 GKTVANLLS--GKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSED 202
Query: 123 APLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATA--GGQGGAARK 180
SSS T +V+ ++ + V+ + APA K A A G G A +
Sbjct: 203 TS------SSSDETDVEVKASEKILQVRAAS----APAKGTPGKGATPAPPGKAGAVASQ 252
Query: 181 EKKGKHKGTSGPAALAEDKSEAQGPVQ--ILTVGQSDHAQDAGETAAGGGERPSGQDLRA 238
K GK + S ++ SE + P +L S G +A E P A
Sbjct: 253 TKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPA 312
Query: 239 TMQRKGISSSMSF----DEDEEDEEENSSSSSQLNSNTRPS---------SATSRKSVRE 285
+ G + + + +ED + E S S + + +PS SA +++S R+
Sbjct: 313 PPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRK 372
Query: 286 AASAPSPTAPEQPVDVEVQ 304
A AP+P P +VQ
Sbjct: 373 GA-APAPPRKTGPAAAQVQ 390
Score = 45.8 bits (107), Expect = 1e-04
Identities = 46/185 (24%), Positives = 79/185 (42%), Gaps = 20/185 (10%)
Query: 108 DGRPRSRRARQSEEQAPLVESYLSS--SGSTSYQVQEADSLASVQLGATRPTAPASAKRT 165
D S + SEE+ P ++ L + SG TS Q+GA A S ++
Sbjct: 261 DSESSSEESSDSEEETPAAKALLQAKASGKTS------------QVGAASAPAKESPRKG 308
Query: 166 KAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAA 225
A A G G A K + GK + S ++ E SE + P Q G++ + A +A
Sbjct: 309 AAPAPPGKTGPAVAKAQAGKREEDS-QSSSEESDSEEEAPAQAKPSGKAPQVRAA---SA 364
Query: 226 GGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVRE 285
E P A ++ G +++ + + EE++ SSS + +S+ +A + V+
Sbjct: 365 PAKESPRKGAAPAPPRKTGPAAAQV--QVGKQEEDSRSSSEESDSDREALAAMNAAQVKP 422
Query: 286 AASAP 290
+P
Sbjct: 423 LGKSP 427
Score = 39.7 bits (91), Expect = 0.007
Identities = 45/207 (21%), Positives = 78/207 (37%), Gaps = 14/207 (6%)
Query: 105 ANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKR 164
A A R ++ S E++ E + + + Q + A + + APA ++
Sbjct: 322 AKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRK 381
Query: 165 TKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDA---- 220
T AA G + + S ALA A Q+ +G+S + A
Sbjct: 382 TGPAAAQVQVGKQEEDSRSSSEESDSDREALA-----AMNAAQVKPLGKSPQVKPASTMG 436
Query: 221 -GETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATS 279
G G G P G+ AT + D + EE + SS ++ + P+ S
Sbjct: 437 MGPLGKGAGPVPPGKVGPATPSAQ--VGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKS 494
Query: 280 RKSVREA--ASAPSPTAPEQPVDVEVQ 304
++ +A S+P+ P++ V VQ
Sbjct: 495 LGNILQAKPTSSPAKGPPQKAGPVAVQ 521
Score = 39.3 bits (90), Expect = 0.010
Identities = 51/240 (21%), Positives = 92/240 (38%), Gaps = 34/240 (14%)
Query: 92 KQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQL 151
K ++ P+ VQ A+ +P + SEE + +S + + T+ Q + A + +
Sbjct: 509 KGPPQKAGPVAVQVKAE-KPMDN-SESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKA 566
Query: 152 GATRPTAPASAK---------RTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEA 202
+ ASAK + A TA G++ G + ++ E SE
Sbjct: 567 CPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 626
Query: 203 QGPVQILTVGQSDHAQDAGETAAG-----------------GGERPSGQDLRATMQRKGI 245
+ +TVGQ+ + A G P+ ++A Q
Sbjct: 627 EKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSE 686
Query: 246 SSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSP-TAPEQPVDVEVQ 304
SS E+E D EE ++S +Q+ ++ + + A + + A SA +AP + V Q
Sbjct: 687 SS-----EEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQ 741
Score = 35.8 bits (81), Expect = 0.11
Identities = 47/212 (22%), Positives = 71/212 (33%), Gaps = 31/212 (14%)
Query: 104 QANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAK 163
QA A PR RA +S ++ SSS S V A + + T P +
Sbjct: 900 QAQAASTPRKARASESTARS-------SSSESEDEDVIPATQCLTPGIRTNVVTMPTAHP 952
Query: 164 RTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEA-----QGPVQILTVGQSD--- 215
R A+ G + + K GPA K+ A Q +++L S+
Sbjct: 953 RIAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQP 1012
Query: 216 ---HAQDAGETAAGGGERPSGQDLRATMQRKG-----------ISSSMSFDEDEEDEEEN 261
Q + + G P+ ++Q KG + + E +D E++
Sbjct: 1013 PVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDS 1072
Query: 262 SSSSSQLNSNTRPSSATSRKSVREAASAPSPT 293
S SSS S KS PS T
Sbjct: 1073 SDSSS--GSEEDGEGPQGAKSAHTLGPTPSRT 1102
>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
Length = 770
Score = 47.0 bits (110), Expect = 5e-05
Identities = 50/255 (19%), Positives = 104/255 (40%), Gaps = 22/255 (8%)
Query: 34 HSKQHRKPGPLKRGHRRDRRTTRRKYWKEGREIARVLDD--EGRNLRQQKLDRQRALLEQ 91
H K ++ K ++R RRK +E ++ AR + + R + ++ R+R LEQ
Sbjct: 99 HRKDEKRKEKWKHARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQ 158
Query: 92 KQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLS-SSGSTSYQVQEADSLASVQ 150
++K+ +E M + + R + R R++EE+ E+ S+ + + +D + +
Sbjct: 159 LERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASH 218
Query: 151 LGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILT 210
+ P P G G KE+K + + L D + + +
Sbjct: 219 WSRSPPRPPRERFEL-------GDGRKPVKEEKMEERD------LLSDLQDISDSERKTS 265
Query: 211 VGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNS 270
+S A+ +G G ++ + S +E+EE+EEE + S+ +
Sbjct: 266 SAESSSAE------SGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEA 319
Query: 271 NTRPSSATSRKSVRE 285
+ + + S + + E
Sbjct: 320 SEQSAEEVSEEEMSE 334
>gi|239743051 PREDICTED: hypothetical protein XP_002342747 [Homo
sapiens]
Length = 306
Score = 47.0 bits (110), Expect = 5e-05
Identities = 55/213 (25%), Positives = 85/213 (39%), Gaps = 37/213 (17%)
Query: 93 QKKKRQEPLMVQANADGRPRSRR---------ARQSEEQAPLVESYLSSSGSTSYQVQEA 143
+K+K Q+P A G+ R R A+ EE+A + SS T +
Sbjct: 85 EKRKPQQPQRRPAGGTGQRRGSRSSSSADQQGAQDREEEAAAAPAPTSSGHRTEKR---- 140
Query: 144 DSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAALAE-DKSEA 202
Q RP A +R + + Q A +E+ + T+ P + ++E
Sbjct: 141 ----KPQQPQCRPAAGTGQRRGSGCSPSADQQRAQDREE----EATAAPVPTSSGHRTEK 192
Query: 203 QGPVQILTVGQSDHAQDAGETAAGGGER--PSGQDLRATMQRKGISSSMSFDEDEEDEEE 260
+ +Q+ Q AG T G R PS Q T QR+G SS S D+ + E
Sbjct: 193 RKRLQL-------QCQPAGGTGQRRGSRSSPSRQPAGGTGQRRGSRSSPSADQQRAQDRE 245
Query: 261 NSSSSSQLNSNTRPSSATSRKSVREAASAPSPT 293
++ Q RP+ T ++ R A+AP PT
Sbjct: 246 EEAAQPQ----RRPAGGTGQR--RGTAAAPVPT 272
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 45.8 bits (107), Expect = 1e-04
Identities = 54/267 (20%), Positives = 107/267 (40%), Gaps = 27/267 (10%)
Query: 27 PWPMGSQHSKQHRKPGPLK-----RGHRRDRRTTRRKYWKEGREIARVLDD--EGRNLRQ 79
P M + HRK K R ++R RRK +E ++ AR + + R + +
Sbjct: 88 PQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAR 147
Query: 80 QKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLS-SSGSTSY 138
+ R+R LEQ ++K+ +E M + + R + R R++EE+ E+ S+ +
Sbjct: 148 EHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTM 207
Query: 139 QVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAALAED 198
+ +D + + + P P G G KE+K + + L D
Sbjct: 208 REDYSDKVKASHWSRSPPRPPRERFEL-------GDGRKPVKEEKMEERD------LLSD 254
Query: 199 KSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDE 258
+ + + +S A+ +G G ++ + S +E+EE+E
Sbjct: 255 LQDISDSERKTSSAESSSAE------SGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEE 308
Query: 259 EENSSSSSQLNSNTRPSSATSRKSVRE 285
EE + S+ ++ + + S + + E
Sbjct: 309 EEEETGSNSEEASEQSAEEVSEEEMSE 335
Score = 43.1 bits (100), Expect = 7e-04
Identities = 67/364 (18%), Positives = 138/364 (37%), Gaps = 64/364 (17%)
Query: 36 KQHRKPGPLKRGHRRDRRTTRRKYWKEGR-EIARVLDDEGRNLRQQ---KLDRQRALLEQ 91
K+ + ++ HR ++ RR++ ++ R E+AR R+ +Q K +R+R + EQ
Sbjct: 114 KEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQ 173
Query: 92 KQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSY------------- 138
+++++ Q+ +A + R R S + E Y ++ +
Sbjct: 174 QKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFE 233
Query: 139 -----------QVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHK 187
+++E D L+ +Q S ++T +A ++ + G+ +E++ +
Sbjct: 234 LGDGRKPVKEEKMEERDLLSDLQ------DISDSERKTSSAESSSAESGSGSEEEEEE-- 285
Query: 188 GTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISS 247
E++ E +G + + + ++ E E S Q + +
Sbjct: 286 ---------EEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEE---- 332
Query: 248 SMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTA-------PEQPVD 300
EDEE E EN + R S + P +A P+ P
Sbjct: 333 ---MSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPAL 389
Query: 301 VEVQDLEEF-ALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLLAGRKR 359
++ +E PA QG CR + + ++R TY + +D K ++A ++
Sbjct: 390 SPIELKQELPKYLPALQG----CRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRL 445
Query: 360 KKSK 363
K K
Sbjct: 446 KMEK 449
Score = 31.2 bits (69), Expect = 2.6
Identities = 47/277 (16%), Positives = 92/277 (33%), Gaps = 37/277 (13%)
Query: 46 RGHRRDRRTTRRKYWKEGREIARVLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMVQA 105
R H + Y +E R +D+ ++ + ++ + ++ +KR+E +
Sbjct: 54 RDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARV 113
Query: 106 NADGRPRSRRARQSEEQAPL---VESYLSSSGSTSYQVQEADSLASVQLGATRP-TAPAS 161
R RR R EEQ E + + +E D L ++ R
Sbjct: 114 KEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQ 173
Query: 162 AKRTKAAATAGGQGGAARKEKKGKHKGTSGPAALAED-----------KSEAQGPVQILT 210
K + + RKE++ + + ++ + ED +S + P +
Sbjct: 174 QKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFE 233
Query: 211 VGQ----------------------SDHAQDAGETAAGGGERPSGQDLRATMQRKGISSS 248
+G SD + + E SG + + +
Sbjct: 234 LGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEG 293
Query: 249 MSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVRE 285
+ +E EE+EEE + SN+ +S S + V E
Sbjct: 294 STSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSE 330
>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
5 [Homo sapiens]
Length = 748
Score = 45.1 bits (105), Expect = 2e-04
Identities = 50/256 (19%), Positives = 104/256 (40%), Gaps = 22/256 (8%)
Query: 33 QHSKQHRKPGPLKRGHRRDRRTTRRKYWKEGREIARVLDD--EGRNLRQQKLDRQRALLE 90
+H + G R ++R RRK +E ++ AR + + R + ++ R+R LE
Sbjct: 76 RHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLE 135
Query: 91 QKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLS-SSGSTSYQVQEADSLASV 149
Q ++K+ +E M + + R + R R++EE+ E+ S+ + + +D + +
Sbjct: 136 QLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKAS 195
Query: 150 QLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQIL 209
+ P P G G KE+K + + L D + +
Sbjct: 196 HWSRSPPRPPRERFEL-------GDGRKPVKEEKMEERD------LLSDLQDISDSERKT 242
Query: 210 TVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLN 269
+ +S A+ +G G ++ + S +E+EE+EEE + S+
Sbjct: 243 SSAESSSAE------SGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEE 296
Query: 270 SNTRPSSATSRKSVRE 285
++ + + S + + E
Sbjct: 297 ASEQSAEEVSEEEMSE 312
Score = 44.3 bits (103), Expect = 3e-04
Identities = 69/371 (18%), Positives = 142/371 (38%), Gaps = 66/371 (17%)
Query: 31 GSQHS--KQHRKPGPLKRGHRRDRRTTRRKYWKEGR-EIARVLDDEGRNLRQQ---KLDR 84
G +H+ K+ + ++ HR ++ RR++ ++ R E+AR R+ +Q K +R
Sbjct: 84 GGKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRER 143
Query: 85 QRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSY------ 138
+R + EQ+++++ Q+ +A + R R S + E Y ++ +
Sbjct: 144 ERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPR 203
Query: 139 ------------------QVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARK 180
+++E D L+ +Q S ++T +A ++ + G+ +
Sbjct: 204 PPRERFELGDGRKPVKEEKMEERDLLSDLQ------DISDSERKTSSAESSSAESGSGSE 257
Query: 181 EKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATM 240
E++ + E++ E +G + + + ++ E E S Q
Sbjct: 258 EEEEE-----------EEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVS 306
Query: 241 QRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTA------ 294
+ + EDEE E EN + R S + P +A
Sbjct: 307 EEE-------MSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDY 359
Query: 295 -PEQPVDVEVQDLEEF-ALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVF 352
P+ P ++ +E PA QG CR + + ++R TY + +D K
Sbjct: 360 VPDSPALSPIELKQELPKYLPALQG----CRSVEEFQCLNRIEEGTYGVVYRAKDKKTDE 415
Query: 353 LLAGRKRKKSK 363
++A ++ K K
Sbjct: 416 IVALKRLKMEK 426
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
2 [Homo sapiens]
Length = 782
Score = 45.1 bits (105), Expect = 2e-04
Identities = 50/256 (19%), Positives = 104/256 (40%), Gaps = 22/256 (8%)
Query: 33 QHSKQHRKPGPLKRGHRRDRRTTRRKYWKEGREIARVLDD--EGRNLRQQKLDRQRALLE 90
+H + G R ++R RRK +E ++ AR + + R + ++ R+R LE
Sbjct: 110 RHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLE 169
Query: 91 QKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLS-SSGSTSYQVQEADSLASV 149
Q ++K+ +E M + + R + R R++EE+ E+ S+ + + +D + +
Sbjct: 170 QLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKAS 229
Query: 150 QLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQIL 209
+ P P G G KE+K + + L D + +
Sbjct: 230 HWSRSPPRPPRERFEL-------GDGRKPVKEEKMEERD------LLSDLQDISDSERKT 276
Query: 210 TVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLN 269
+ +S A+ +G G ++ + S +E+EE+EEE + S+
Sbjct: 277 SSAESSSAE------SGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEE 330
Query: 270 SNTRPSSATSRKSVRE 285
++ + + S + + E
Sbjct: 331 ASEQSAEEVSEEEMSE 346
Score = 44.3 bits (103), Expect = 3e-04
Identities = 69/371 (18%), Positives = 142/371 (38%), Gaps = 66/371 (17%)
Query: 31 GSQHS--KQHRKPGPLKRGHRRDRRTTRRKYWKEGR-EIARVLDDEGRNLRQQ---KLDR 84
G +H+ K+ + ++ HR ++ RR++ ++ R E+AR R+ +Q K +R
Sbjct: 118 GGKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRER 177
Query: 85 QRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSY------ 138
+R + EQ+++++ Q+ +A + R R S + E Y ++ +
Sbjct: 178 ERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPR 237
Query: 139 ------------------QVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARK 180
+++E D L+ +Q S ++T +A ++ + G+ +
Sbjct: 238 PPRERFELGDGRKPVKEEKMEERDLLSDLQ------DISDSERKTSSAESSSAESGSGSE 291
Query: 181 EKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATM 240
E++ + E++ E +G + + + ++ E E S Q
Sbjct: 292 EEEEE-----------EEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVS 340
Query: 241 QRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTA------ 294
+ + EDEE E EN + R S + P +A
Sbjct: 341 EEE-------MSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDY 393
Query: 295 -PEQPVDVEVQDLEEF-ALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVF 352
P+ P ++ +E PA QG CR + + ++R TY + +D K
Sbjct: 394 VPDSPALSPIELKQELPKYLPALQG----CRSVEEFQCLNRIEEGTYGVVYRAKDKKTDE 449
Query: 353 LLAGRKRKKSK 363
++A ++ K K
Sbjct: 450 IVALKRLKMEK 460
>gi|55741677 SET domain containing 1A [Homo sapiens]
Length = 1707
Score = 44.7 bits (104), Expect = 2e-04
Identities = 45/211 (21%), Positives = 72/211 (34%), Gaps = 5/211 (2%)
Query: 94 KKKRQEPLMV-QANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLG 152
K KR+EP + +A+ + RPR + +E P E G + + D + G
Sbjct: 894 KVKRKEPSEISEASEEKRPRPSTPAEEDEDDPEQEKEAGEPGRPGTKPPKRDE----ERG 949
Query: 153 ATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVG 212
T+ S A + + + E+ + A D ++ + V
Sbjct: 950 KTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKETEVSDGEDE 1009
Query: 213 QSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNT 272
+SD + A GE S D ++ SSS S + SSS
Sbjct: 1010 ESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEE 1069
Query: 273 RPSSATSRKSVREAASAPSPTAPEQPVDVEV 303
RP++ S P+P E PV V
Sbjct: 1070 RPAALPSASPPPREVPVPTPAPVEVPVPERV 1100
Score = 38.9 bits (89), Expect = 0.013
Identities = 67/269 (24%), Positives = 94/269 (34%), Gaps = 54/269 (20%)
Query: 37 QHRKPGPLKRGHRRDRRTTRRKYWKEGREIARVLDDE-GRNLRQQKLDRQRALLEQKQKK 95
Q + PGP R R T R + + + +E R R + R R E++ +
Sbjct: 1188 QAKFPGPASRKAPRGVERTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEEEAEP 1247
Query: 96 KRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLG--- 152
+ L V A+ P AR+ P VE S + TS + + L S L
Sbjct: 1248 GTEVDLAVLADLALTP----ARRGLPALPAVED--SEATETSDEAERPRPLLSHILLEHN 1301
Query: 153 ---ATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQIL 209
A +PT PA A R A PAAL +
Sbjct: 1302 YALAVKPTPPAPALRPPEPVPA--------------------PAALFSSPA--------- 1332
Query: 210 TVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLN 269
D +A E E P Q L+ Q++ +E EE+EEE+S SSS +
Sbjct: 1333 -----DEVLEAPEVVVAEAEEPKPQQLQ---QQREEGEEEGEEEGEEEEEESSDSSSSSD 1384
Query: 270 SNTRPSSATSRKSVREAASAPSPTAPEQP 298
A R+S+R A P P P
Sbjct: 1385 G----EGALRRRSLRSHARRRRPPPPPPP 1409
>gi|153070260 myristoylated alanine-rich protein kinase C substrate
[Homo sapiens]
Length = 332
Score = 43.5 bits (101), Expect = 5e-04
Identities = 53/232 (22%), Positives = 88/232 (37%), Gaps = 17/232 (7%)
Query: 85 QRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEAD 144
+ A+ K QE V+ N D P + + EE L ++GS +E
Sbjct: 21 EAAVASSPSKANGQENGHVKVNGDASPAAAESGAKEE--------LQANGSAPAADKEEP 72
Query: 145 SLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQG 204
+ A GA P+A A++ + AA A + GA+ EK+ G AA + A+G
Sbjct: 73 AAAGS--GAASPSA---AEKGEPAAAAAPEAGASPVEKEAP---AEGEAAEPGSPTAAEG 124
Query: 205 PVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSS 264
S + G T + E P + R + ++ S SF +++++ E +
Sbjct: 125 EAASAASSTSSPKAEDGATPSPSNETPKKKKKRFSFKKSFKLSGFSFKKNKKEAGEGGEA 184
Query: 265 SSQLNSNTRPSSATSRKSVREAASAPSPTAPEQPVDVEVQDLEEFALRPAPQ 316
+ + +A + A A S P + E EE A PQ
Sbjct: 185 EAPAAEGGKDEAAGGAAAAAAEAGAASGEQAAAPGE-EAAAGEEGAAGGDPQ 235
Score = 33.5 bits (75), Expect = 0.53
Identities = 43/156 (27%), Positives = 61/156 (39%), Gaps = 21/156 (13%)
Query: 161 SAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDA 220
S K+ K A GG+ A E GK + G AA A + A G Q G+ A +
Sbjct: 170 SFKKNKKEAGEGGEAEAPAAEG-GKDEAAGGAAAAAAEAGAASGE-QAAAPGEEAAAGEE 227
Query: 221 GETAAGGGERPSGQDLRATMQRKGISS--SMSFDEDEEDEEENSSSSSQLNSNTRPSSAT 278
G AAGG + + A K +S + + +E + EE+ + + +SA
Sbjct: 228 G--AAGGDPQEAKPQEAAVAPEKPPASDETKAAEEPSKVEEKKAEEAG--------ASAA 277
Query: 279 SRKSVREAASAPSPTAPEQPVDVEVQDLEEFALRPA 314
A APS P P + E EE A A
Sbjct: 278 -------ACEAPSAAGPGAPPEQEAAPAEEPAAAAA 306
>gi|21361272 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 1 [Homo sapiens]
Length = 559
Score = 42.7 bits (99), Expect = 9e-04
Identities = 58/265 (21%), Positives = 108/265 (40%), Gaps = 38/265 (14%)
Query: 45 KRGHRRDRRTTR-RKYWKEGREIARVLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMV 103
K ++ +T++ K KE RE R D E ++ ++L+R++A + +K E +
Sbjct: 182 KDANKESSKTSKPHKVTKEHRERPRK-DSESKS-SSKELEREQAKSSKDTSRKLGEGRLP 239
Query: 104 QANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAK 163
+ P+ A E + L E+ L S+ S + G P P
Sbjct: 240 KEEKAPPPK---AAFKEPKMALKETKLEST--------------SPKGGPPPPPPPPPRA 282
Query: 164 RTKAAATAGGQGGAARKEKKGKHKGT-SGPAALAEDKSEAQGPVQILTVGQSDHAQDAGE 222
+K ATA +A+K+KK KG+ S P S + + A+D
Sbjct: 283 SSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSS-------SFSDKKPAKDKSS 335
Query: 223 TAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKS 282
T G+ ++A + + ++ +E ++E + S S +S + SS++ S
Sbjct: 336 T--------RGEKVKAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSS 387
Query: 283 VREAASAPSPTAPEQPVDVEVQDLE 307
++ PS + P+ V+DL+
Sbjct: 388 --DSDFEPSQNHSQGPLRSMVEDLQ 410
>gi|156104889 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 3 [Homo sapiens]
Length = 568
Score = 42.0 bits (97), Expect = 0.001
Identities = 59/275 (21%), Positives = 106/275 (38%), Gaps = 20/275 (7%)
Query: 36 KQHR-KPGPLKRGHRRDRRTTRRKYWKEGREIARVLDDEGRNLRQQKLDRQRALLEQKQK 94
K+H+ KP R H+ + R + K +E ++ E + L+++K+ + A E K
Sbjct: 201 KEHKEKPSKDSREHKSAFKEPSRDHNKSSKESSKK-PKENKPLKEEKIVPKMAFKEPKPM 259
Query: 95 KKRQEP----LMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQ 150
K +P L + + D + S+R S+ + + SS ++ S +
Sbjct: 260 SKEPKPDSNLLTITSGQDKKAPSKRPPISDSEELSAKKRKKSSSEALFK--SFSSAPPLI 317
Query: 151 LGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILT 210
L T A K+ K + E K K T P D +++ I +
Sbjct: 318 L-----TCSADKKQIKDKSHVKMGKVKIESETSEKKKSTLPPFDDIVDPNDSDVEENISS 372
Query: 211 VGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEE-DEEENSSSSSQLN 269
S+ A +++ Q + R + S D +EE DE E++ + S++
Sbjct: 373 KSDSEQPSPASSSSSSSSSFTPSQTRQQGPLRSIMKDLHSDDNEEESDEVEDNDNDSEME 432
Query: 270 SNTRPSSATSRK------SVREAASAPSPTAPEQP 298
+ SR+ S E++SA SP E P
Sbjct: 433 RPVNRGGSRSRRVSLSDGSDSESSSASSPLHHEPP 467
Score = 30.0 bits (66), Expect = 5.9
Identities = 23/76 (30%), Positives = 33/76 (43%), Gaps = 4/76 (5%)
Query: 225 AGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATS----R 280
AGG S ++ SSS S +SSSSS +S++ SS+TS
Sbjct: 138 AGGDPNRSIHTSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSFSKPH 197
Query: 281 KSVREAASAPSPTAPE 296
K ++E PS + E
Sbjct: 198 KLMKEHKEKPSKDSRE 213
>gi|31377595 zinc finger CCCH-type containing 18 [Homo sapiens]
Length = 953
Score = 42.0 bits (97), Expect = 0.001
Identities = 68/288 (23%), Positives = 105/288 (36%), Gaps = 52/288 (18%)
Query: 37 QHRKPGPLKRGHRRDRRTTRRKYWKEGREIARVLDDEGRNLRQQKLDRQRALLEQKQKKK 96
Q+ + P R+R R +E RE R D E R RQ++ +R+R K++++
Sbjct: 391 QYTETEPYHNYRERERERERENRQRE-RERERERDRE-RERRQREREREREHERDKERQR 448
Query: 97 RQEPL-MVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATR 155
R+E +A D + R R R E++ + G +
Sbjct: 449 RKEEWERERAKRDEKDRQHRDRDREKER------------------------EKEKGKPK 484
Query: 156 PTAPASAKRT-----KAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILT 210
P +P R K AAT G Q A + K + S L S ++ + T
Sbjct: 485 PRSPQPPSRQAEPPKKEAATTGPQVKRADEWKDPWRRSKSPKKKLGVSVSPSRARRRRKT 544
Query: 211 VGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNS 270
A +A R S + SSS S +SS SS +
Sbjct: 545 --------SASSASASNSSRSSSR-----------SSSYSGSGSSRSRSRSSSYSSYSSR 585
Query: 271 NTRPSSAT-SRKSVREAASAPSPTAPEQPVDVEVQDLEEFALRPAPQG 317
++R SS + SR R +S+PSP+ P ++ E A P G
Sbjct: 586 SSRHSSFSGSRSRSRSFSSSPSPSPTPSPHRPSIRTKGEPAPPPGKAG 633
>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
8 [Homo sapiens]
Length = 780
Score = 41.6 bits (96), Expect = 0.002
Identities = 50/252 (19%), Positives = 102/252 (40%), Gaps = 23/252 (9%)
Query: 36 KQHRKPGPLKRGHRRDRRTTRRKYWKEGR-EIARVLDDEGRNLRQQKLDRQRALLEQKQK 94
K+ + ++ HR ++ RR++ ++ R E+AR R L R R LEQ ++
Sbjct: 114 KEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERGNDGVCLFRDR--LEQLER 171
Query: 95 KKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLS-SSGSTSYQVQEADSLASVQLGA 153
K+ +E M + + R + R R++EE+ E+ S+ + + +D + +
Sbjct: 172 KRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSR 231
Query: 154 TRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQ 213
+ P P G G KE+K + + L D + + + +
Sbjct: 232 SPPRPPRERFEL-------GDGRKPVKEEKMEERD------LLSDLQDISDSERKTSSAE 278
Query: 214 SDHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTR 273
S A+ +G G ++ + S +E+EE+EEE + S+ ++ +
Sbjct: 279 SSSAE------SGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQ 332
Query: 274 PSSATSRKSVRE 285
+ S + + E
Sbjct: 333 SAEEVSEEEMSE 344
>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a
[Homo sapiens]
Length = 624
Score = 41.6 bits (96), Expect = 0.002
Identities = 49/258 (18%), Positives = 103/258 (39%), Gaps = 21/258 (8%)
Query: 33 QHSKQHRKPGPLKRGHRRDRRTTRRKYWKEGREIARVLDDEGRNLRQQKLDRQRALLEQK 92
+ SK + R H RD+R R+ KE +E + D E R+++ ++++ + K
Sbjct: 357 KRSKSRERRKSRSRSHSRDKRKDTREKIKE-KERVKEKDREKEREREKEREKEKERGKNK 415
Query: 93 QKKKRQEPLMVQANADGRPRSR-------RARQSEEQAPLVESYLSSSGSTSYQVQEADS 145
+ K +E + R R R R ++ E++ + + ++ D
Sbjct: 416 DRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDK 475
Query: 146 LASV---QLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEA 202
+ A+R + +S +R + + + + + R K K K + P+ + +K +
Sbjct: 476 KSRTPPRSYNASRRSRSSSRERRRRRSRSSSR--SPRTSKTIKRKSSRSPSPRSRNKKDK 533
Query: 203 QGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENS 262
+ + DH + E R S D + K +S S E E ++E +S
Sbjct: 534 K------REKERDHISERRERERSTSMRKSSNDRDG--KEKLEKNSTSLKEKEHNKEPDS 585
Query: 263 SSSSQLNSNTRPSSATSR 280
S S +++ P + ++
Sbjct: 586 SVSKEVDDKDAPRTEENK 603
>gi|21040255 splicing factor, arginine/serine-rich 12 isoform b
[Homo sapiens]
Length = 508
Score = 41.6 bits (96), Expect = 0.002
Identities = 49/258 (18%), Positives = 103/258 (39%), Gaps = 21/258 (8%)
Query: 33 QHSKQHRKPGPLKRGHRRDRRTTRRKYWKEGREIARVLDDEGRNLRQQKLDRQRALLEQK 92
+ SK + R H RD+R R+ KE +E + D E R+++ ++++ + K
Sbjct: 241 KRSKSRERRKSRSRSHSRDKRKDTREKIKE-KERVKEKDREKEREREKEREKEKERGKNK 299
Query: 93 QKKKRQEPLMVQANADGRPRSR-------RARQSEEQAPLVESYLSSSGSTSYQVQEADS 145
+ K +E + R R R R ++ E++ + + ++ D
Sbjct: 300 DRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDK 359
Query: 146 LASV---QLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEA 202
+ A+R + +S +R + + + + + R K K K + P+ + +K +
Sbjct: 360 KSRTPPRSYNASRRSRSSSRERRRRRSRSSSR--SPRTSKTIKRKSSRSPSPRSRNKKDK 417
Query: 203 QGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENS 262
+ + DH + E R S D + K +S S E E ++E +S
Sbjct: 418 K------REKERDHISERRERERSTSMRKSSNDRDG--KEKLEKNSTSLKEKEHNKEPDS 469
Query: 263 SSSSQLNSNTRPSSATSR 280
S S +++ P + ++
Sbjct: 470 SVSKEVDDKDAPRTEENK 487
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.128 0.365
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,460,450
Number of Sequences: 37866
Number of extensions: 1115296
Number of successful extensions: 9661
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 88
Number of HSP's successfully gapped in prelim test: 431
Number of HSP's that attempted gapping in prelim test: 7720
Number of HSP's gapped (non-prelim): 1842
length of query: 561
length of database: 18,247,518
effective HSP length: 107
effective length of query: 454
effective length of database: 14,195,856
effective search space: 6444918624
effective search space used: 6444918624
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.