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Search of human proteins with 19920317
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|19920317 cytoskeleton-associated protein 4 [Homo sapiens]
(602 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|19920317 cytoskeleton-associated protein 4 [Homo sapiens] 1155 0.0
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 87 6e-17
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 80 4e-15
gi|190341068 forkhead-associated (FHA) phosphopeptide binding do... 80 5e-15
gi|70166580 GRINL1A upstream protein isoform 7 [Homo sapiens] 80 7e-15
gi|70166430 GRINL1A combined protein isoform 2 [Homo sapiens] 78 2e-14
gi|70166414 GRINL1A combined protein isoform 1 [Homo sapiens] 78 2e-14
gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapi... 78 2e-14
gi|38044112 restin isoform b [Homo sapiens] 78 3e-14
gi|4506751 restin isoform a [Homo sapiens] 78 3e-14
gi|16262452 cingulin [Homo sapiens] 76 1e-13
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 75 2e-13
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 73 7e-13
gi|157785668 coiled-coil domain containing 39 [Homo sapiens] 73 7e-13
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 73 9e-13
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 71 2e-12
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 71 2e-12
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 71 2e-12
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 71 2e-12
gi|21735548 centrosomal protein 2 [Homo sapiens] 71 3e-12
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 71 3e-12
gi|28416946 myosin 18A isoform a [Homo sapiens] 70 4e-12
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 70 7e-12
gi|194353964 coiled-coil domain containing 157 [Homo sapiens] 69 9e-12
gi|31542634 filamin A interacting protein 1 [Homo sapiens] 69 9e-12
gi|34577114 cytomatrix protein p110 [Homo sapiens] 69 1e-11
gi|71061468 centromere protein E [Homo sapiens] 69 2e-11
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 69 2e-11
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 69 2e-11
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 69 2e-11
>gi|19920317 cytoskeleton-associated protein 4 [Homo sapiens]
Length = 602
Score = 1155 bits (2988), Expect = 0.0
Identities = 602/602 (100%), Positives = 602/602 (100%)
Query: 1 MPSAKQRGSKGGHGAASPSEKGAHPSGGADDVAKKPPPAPQQPPPPPAPHPQQHPQQHPQ 60
MPSAKQRGSKGGHGAASPSEKGAHPSGGADDVAKKPPPAPQQPPPPPAPHPQQHPQQHPQ
Sbjct: 1 MPSAKQRGSKGGHGAASPSEKGAHPSGGADDVAKKPPPAPQQPPPPPAPHPQQHPQQHPQ 60
Query: 61 NQAHGKGGHRGGGGGGGKSSSSSSASAAAAAAAASSSASCSRRLGRALNFLFYLALVAAA 120
NQAHGKGGHRGGGGGGGKSSSSSSASAAAAAAAASSSASCSRRLGRALNFLFYLALVAAA
Sbjct: 61 NQAHGKGGHRGGGGGGGKSSSSSSASAAAAAAAASSSASCSRRLGRALNFLFYLALVAAA 120
Query: 121 AFSGWCVHHVLEEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQ 180
AFSGWCVHHVLEEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQ
Sbjct: 121 AFSGWCVHHVLEEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQ 180
Query: 181 HKQDLTEKAVKQGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEER 240
HKQDLTEKAVKQGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEER
Sbjct: 181 HKQDLTEKAVKQGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEER 240
Query: 241 LTELTKSINDNIAIFTEVQKRSQKEINDMKAKVASLEESEGNKQDLKALKEAVKEIQTSA 300
LTELTKSINDNIAIFTEVQKRSQKEINDMKAKVASLEESEGNKQDLKALKEAVKEIQTSA
Sbjct: 241 LTELTKSINDNIAIFTEVQKRSQKEINDMKAKVASLEESEGNKQDLKALKEAVKEIQTSA 300
Query: 301 KSREWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSE 360
KSREWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSE
Sbjct: 301 KSREWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSE 360
Query: 361 ESVSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGV 420
ESVSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGV
Sbjct: 361 ESVSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGV 420
Query: 421 LSMQVASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQL 480
LSMQVASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQL
Sbjct: 421 LSMQVASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQL 480
Query: 481 VLYGDVEELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLSSLDNLK 540
VLYGDVEELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLSSLDNLK
Sbjct: 481 VLYGDVEELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLSSLDNLK 540
Query: 541 ASVSQVEADLKMLRTAVDSLVAYSVKIETNENNLESAKGLLDDLRNDLDRLFVKVEKIHE 600
ASVSQVEADLKMLRTAVDSLVAYSVKIETNENNLESAKGLLDDLRNDLDRLFVKVEKIHE
Sbjct: 541 ASVSQVEADLKMLRTAVDSLVAYSVKIETNENNLESAKGLLDDLRNDLDRLFVKVEKIHE 600
Query: 601 KV 602
KV
Sbjct: 601 KV 602
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 86.7 bits (213), Expect = 6e-17
Identities = 111/491 (22%), Positives = 231/491 (47%), Gaps = 41/491 (8%)
Query: 132 EEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVK 191
+E+ QV+ + + +RE + L+ +K+QS A+ S LRS K
Sbjct: 228 KELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAK--------- 278
Query: 192 QGESEVSRISEVLQKLQNEILKDLSDGIHVVKD---ARERDFTSLENTVEERLTE---LT 245
G EV+ + LQKL++ + +L+ + + +E+D+T LE E +
Sbjct: 279 -GPQEVAVYVQELQKLKSSV-NELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQ 336
Query: 246 KSINDNIAIFTEVQKR-SQKEINDMKAKVASLEESEGNKQDLKALKEAVKEIQTSAKSRE 304
+++ ++Q R S E + + V E+ E ++ LKE + E++T + +
Sbjct: 337 ATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQK----LKEELSEVETKYQHLK 392
Query: 305 WDMEALRSTLQTMES---DIYTEVRELVS-LKQEQQAFKEAADTERLALQALTEKLLRSE 360
+ + L+ + E + +E+ +L S L + ++ EA + Q +EKL+ E
Sbjct: 393 AEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKE 452
Query: 361 ESVSRLPEEIRRLEEELRQLKSDSHGPKE--DGGFRHSEAFEALQQKSQGLDSRLQHVED 418
+ V+ L ++ RLEE+L++ ++S + D + + +ALQQ + Q+ +
Sbjct: 453 QQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLE 512
Query: 419 GVLSMQVASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGET 478
VL ++ ++LE+LL KS+E+ ++ L+ E L + +G + + L E
Sbjct: 513 QVLRQIGDKDQKIQNLEALLQKSKEN---ISLLEKEREDLYAKIQAGEGETAVLNQLQEK 569
Query: 479 QLVLYGDVEELKRSVGELPSTVESLQKVQEQVHTLLSQDQ-----AQAARLPPQDFLDRL 533
L V +L +L + ES ++ QE +H + + + AQ L + ++ L
Sbjct: 570 NHTLQEQVTQLTE---KLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNEL 626
Query: 534 SS-LDNLKASVSQVEADLK-MLRTAVDSLVAYSVKIETNENNLESAKGLLDDLRNDLDRL 591
+S L+ K VSQ++ +K + + A + + +N+L++A+ L D + +L+++
Sbjct: 627 NSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKI 686
Query: 592 FVKVEKIHEKV 602
+++++ K+
Sbjct: 687 TTQLDQVTAKL 697
Score = 75.5 bits (184), Expect = 1e-13
Identities = 109/487 (22%), Positives = 212/487 (43%), Gaps = 68/487 (13%)
Query: 131 LEEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAV 190
L+++QQ R+ + D + EL + L+ ++ V S + + + S+ + + +K
Sbjct: 750 LQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRL------DLQKKSEALESIKQKLT 803
Query: 191 KQGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSIND 250
KQ E + +ILK + + L N ++ +TEL K +
Sbjct: 804 KQEE-------------EKQILKQ---DFETLSQETKIQHEELNNRIQTTVTELQKVKME 847
Query: 251 NIAIFTEVQKRSQKEINDMKAKVASL---EESEGNKQDLKALKEAVKEIQTSAKSREWDM 307
A+ TE+ + D +KV+ +SE K++ K K A+ +++ + K
Sbjct: 848 KEALMTELST-----VKDKLSKVSDSLKNSKSEFEKENQKG-KAAILDLEKTCKE----- 896
Query: 308 EALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSRLP 367
L+ LQ + E +EL K+ + KEA+ +L L ++ E+L++++ ++ +
Sbjct: 897 --LKHQLQVQMENTLKEQKEL---KKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNE 951
Query: 368 EEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQVAS 427
+E ++L+ + +LK S K+ E A+ QK++ L+++LQ A
Sbjct: 952 KEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTE-LENKLQQQLTQAAQELAAE 1010
Query: 428 ARQTESLESLLSKSQEHEQRLAA-LQGRLEGLGSSEAD-----------QDGLASTVRSL 475
+ L++ KSQE ++L + GR L ++ D Q+ L S +
Sbjct: 1011 KEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQI 1070
Query: 476 GETQLVLYGDVEELKRSVGEL-PSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLS 534
G + ++ELK + L + + Q++QE+ L QD + L ++ ++ S
Sbjct: 1071 GNQNKL----IQELKTAKATLEQDSAKKEQQLQERCKAL--QDIQKEKSLKEKELVNEKS 1124
Query: 535 SLDNLKASVSQVEADLKMLRTAVDSLVAYSVKIETNENNLESAKGLLD----DLRNDLDR 590
L ++ + E ++ L + S S+K T NL+ AK LL +L+ D
Sbjct: 1125 KLAEIEEIKCRQEKEITKLNEELKSHKLESIKEIT---NLKDAKQLLIQQKLELQGKADS 1181
Query: 591 LFVKVEK 597
L VE+
Sbjct: 1182 LKAAVEQ 1188
Score = 74.7 bits (182), Expect = 2e-13
Identities = 101/522 (19%), Positives = 222/522 (42%), Gaps = 86/522 (16%)
Query: 130 VLEEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSS-------QHK 182
+LE +Q+ +H QR+ + L EQ+V LQ E L+ QH+
Sbjct: 423 LLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQ 482
Query: 183 QDLTEKAVKQGESEVSRISEVLQKLQN---EILKDLSDGIHVVKDARERDFTSLENTVEE 239
D T++ ++ ++ + L++ QN ++L+ + D KD + ++ +L +E
Sbjct: 483 LDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGD-----KDQKIQNLEALLQKSKE 537
Query: 240 RLTELTKSIND----------NIAIFTEVQKRS---QKEINDMKAKVASLEESEGNKQD- 285
++ L K D A+ ++Q+++ Q+++ + K+ + ES Q+
Sbjct: 538 NISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQEN 597
Query: 286 -----------LKALKEAVKEIQTSAKSREWDMEALRSTLQTMESDIYTEVRELVSLKQE 334
L+A ++ V ++TS + + + ++ I + L+S +
Sbjct: 598 LHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAA 657
Query: 335 QQA----FKEAADTERLALQALTEKLLRSEESVSRLPEEIRRLEEELRQLKSDSHGPKED 390
+ A + DT + ALQ ++L + + ++ +++ +E QL+S
Sbjct: 658 KTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLK----- 712
Query: 391 GGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQVASARQTESLESLLSKSQEHEQRLAA 450
+ E + +L+QK++ L+ +++ +E L ++ + + + L+ + + E R
Sbjct: 713 ---EYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATE 769
Query: 451 LQGRLEG----LGSSEADQDGLASTVRSL-------GETQLVLYGDVEELKRSV------ 493
L +LE + S+ D + + S+ E + +L D E L +
Sbjct: 770 LSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEE 829
Query: 494 --GELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLSSLDNLKASVSQVEADLK 551
+ +TV LQKV+ + L+++ +D L ++S D+LK S S+ E + +
Sbjct: 830 LNNRIQTTVTELQKVKMEKEALMTELST------VKDKLSKVS--DSLKNSKSEFEKENQ 881
Query: 552 MLRTAVDSL------VAYSVKIETNENNLESAKGLLDDLRND 587
+ A+ L + + ++++ EN L+ K L L +
Sbjct: 882 KGKAAILDLEKTCKELKHQLQVQM-ENTLKEQKELKKSLEKE 922
Score = 64.3 bits (155), Expect = 3e-10
Identities = 103/496 (20%), Positives = 208/496 (41%), Gaps = 67/496 (13%)
Query: 128 HHVLEEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTE 187
+H L+E QV + + Q E Q + + +VQ +A LR++Q + E
Sbjct: 570 NHTLQE--QVTQLTEKLKNQSESHKQAQENLHDQVQEQKAH-------LRAAQDRVLSLE 620
Query: 188 KAVKQGESEVSRISEVLQKLQNEILK--DLSDGIHVVKDARERDFTS----LENTVEERL 241
+V + S+++ E + +L +I +L K A+ D + +N ++++
Sbjct: 621 TSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQ 680
Query: 242 TELTKSINDNIAIFTEVQKRSQ------KEINDMKAKVASLEE-SEGNKQDLKALKEAVK 294
EL K + ++Q + + + + K K SLE+ +E + +K L+
Sbjct: 681 QELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSL 740
Query: 295 EIQTSAKSREWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTE 354
E++ S + D++ R + +D+ EL ++ + KE + RL LQ
Sbjct: 741 EVKASKEQALQDLQQQRQ----LNTDLELRATEL---SKQLEMEKEIVSSTRLDLQ---- 789
Query: 355 KLLRSEESVSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQ 414
+ E++ + +++ + EEE + LK D ++ +H E L + Q + LQ
Sbjct: 790 ---KKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEE----LNNRIQTTVTELQ 842
Query: 415 HV--EDGVLSMQVASARQ-----TESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDG 467
V E L ++++ + ++SL++ S+ ++ Q+ A LE Q
Sbjct: 843 KVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQ-- 900
Query: 468 LASTVRSLGETQLVLYGDVEELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQ 527
L + + + Q L +E+ K + +L + S+Q+ Q L Q++ + +L Q
Sbjct: 901 LQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQL--Q 958
Query: 528 DFLDRL-SSLDNLKASVSQVEADLKM---------------LRTAVDSLVAYSVKIETNE 571
++ L S + K + ++ +LK+ L A L A KI +
Sbjct: 959 GNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQ 1018
Query: 572 NNLESAKGLLDDLRND 587
NN E ++ L++D
Sbjct: 1019 NNYEKSQETFKQLQSD 1034
Score = 44.7 bits (104), Expect = 3e-04
Identities = 74/358 (20%), Positives = 148/358 (41%), Gaps = 75/358 (20%)
Query: 241 LTELTKSINDNIAIFTEVQKRSQKEINDMKAKVASLEESEG--------NKQDLKALKEA 292
+T L + + D A E +K +E+ K L++ E + +L++L++
Sbjct: 85 VTLLRQEVQDLQASLKE-EKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQ 143
Query: 293 VKEIQTSAKSREWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQAL 352
++E QT ++++ ++ + + + TE+ ++ S E+++ +EAA
Sbjct: 144 LEEAQTE----NFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAA---------- 189
Query: 353 TEKLLRSEESVSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKS----QG 408
E+ V+RL EE+ + ++ LK+ E LQ+
Sbjct: 190 -------EQKVTRLTEELNKEATVIQDLKT-----------------ELLQRPGIEDVAV 225
Query: 409 LDSRLQHVEDGVLSMQVASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGL 468
L L V+ + +M + R++E L+ K Q SSEA L
Sbjct: 226 LKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQ-------------YASSEATISQL 272
Query: 469 ASTVRSLGETQLVLYGDVEELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQD 528
S + + V ++++LK SV EL QK Q LL ++Q +L +
Sbjct: 273 RSELAKGPQEVAVYVQELQKLKSSVNEL------TQKNQTLTENLLKKEQ-DYTKLEEKH 325
Query: 529 FLDRLSSLDNLKASVSQVEADLKML--RTAVDSLVAYSVKIETNENNLESAKGLLDDL 584
+ +S N++A++ Q + D + L R + + + +E +E E+ + L ++L
Sbjct: 326 NEESVSK-KNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKG-EATQKLKEEL 381
Score = 41.6 bits (96), Expect = 0.002
Identities = 56/250 (22%), Positives = 108/250 (43%), Gaps = 46/250 (18%)
Query: 156 QGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVKQGESEVSRISEVLQKLQNEILKDL 215
Q +K Q LQ + I Q ++ L EK + +S+++ I E+ + + EI K L
Sbjct: 1089 QDSAKKEQQLQERCKALQDI----QKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITK-L 1143
Query: 216 SDGIHVVKDARERDFTSLENT----VEERLTELTKSINDNIAIFTEVQKRSQKEIND--- 268
++ + K ++ T+L++ ++++L K+ D++ E +KR+Q+ + D
Sbjct: 1144 NEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKA--DSLKAAVEQEKRNQQILKDQVK 1201
Query: 269 --------------------MKAKVASLEESEGNKQDLKALKEAVKEIQTSAKSREWDME 308
+K K +++ E N+ L A+ E + K +EW
Sbjct: 1202 KEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVK-KEWQSS 1260
Query: 309 ALR-STLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSRLP 367
R S L+ D+ E+ L + Q Q ER +AL E+ L+ E + +L
Sbjct: 1261 QRRVSELEKQTDDLRGEIAVLEATVQNNQ-------DER---RALLERCLKGEGEIEKLQ 1310
Query: 368 EEIRRLEEEL 377
++ L+ +L
Sbjct: 1311 TKVLELQRKL 1320
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 80.5 bits (197), Expect = 4e-15
Identities = 110/509 (21%), Positives = 218/509 (42%), Gaps = 57/509 (11%)
Query: 135 QQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQ-DLTEKAVKQG 193
+++ +SH ++ ++ E L L V K +A + L + + Q +L+E+ Q
Sbjct: 118 KELEQSHINYVKEIENLKNELMAVRSKYSEDKANL---QKQLEEAMNTQLELSEQLKFQN 174
Query: 194 ESE--VSRISEVLQKLQ---NEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSI 248
SE V ++ E ++K++ E + L + D ++ T L+N +E K+I
Sbjct: 175 NSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNI 234
Query: 249 NDNIAIFTEVQKRSQKEINDMKAKV-ASLEESEGNKQDLKALKE-AVKEIQTSAKS---- 302
N +++ Q+E+ ++ ++ AS +E E L LKE VK+ + S K+
Sbjct: 235 NSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKK 294
Query: 303 REWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEES 362
E ++E LR D ++ S+ ++ F E E++ T K L S+ S
Sbjct: 295 YECELENLRKATSNANQD-----NQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHS 349
Query: 363 VSRLPEEIR-------RLEEELRQLKSDSHGPKEDGGFRHSE----------AFEALQQK 405
+ L +E+ +LE + + +K + +ED F+ +E E L+ +
Sbjct: 350 I--LKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSE 407
Query: 406 SQGLDSRL-----QHVEDGVLSMQVASARQTESL-ESLLSKSQEHEQRLA-ALQGRLEGL 458
GL+ + QH + V S++ ++ L E+ LS S++ + L +QG E
Sbjct: 408 LAGLNKQFCYTVEQHNRE-VQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQC 466
Query: 459 GSSEADQDGLASTVRSLGETQLVLYGDVEELKRSVGELPSTVESLQKVQ-EQVHTLLSQD 517
+ + ++ SL E +L EL S G++ ES+++ Q VH L Q
Sbjct: 467 ENLQQEKQEAILNYESLREIMEILQ---TELGESAGKISQEFESMKQQQASDVHEL--QQ 521
Query: 518 QAQAARLPPQDFLDRLSSLDNLKASVSQVEADLKMLRTAVDSLV----AYSVKIETNENN 573
+ + A L+ ++ L + + + L + +L Y + + +
Sbjct: 522 KLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTM 581
Query: 574 LESAKGLLDDLRNDLDRLFVKVEKIHEKV 602
L+ +G ++ L + D K++ HE++
Sbjct: 582 LKELEGKINSLTEEKDDFINKLKNSHEEM 610
Score = 57.8 bits (138), Expect = 3e-08
Identities = 94/493 (19%), Positives = 209/493 (42%), Gaps = 77/493 (15%)
Query: 132 EEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQ----ATFGTFESILRSSQHKQDLTE 187
E + ++ + + QR+E + +E++++ LQ +S+LR + ++ L
Sbjct: 788 ESLAKINEEKCNLAFQRDEK---VLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLR 844
Query: 188 KAVKQGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKS 247
K +++ +SE + L +++N K + +++ E T ++ + +
Sbjct: 845 KELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIK 904
Query: 248 INDNIAIFTEVQKRSQKEINDMKAKVA----SLEESEGNKQD----LKALKEAVKEIQTS 299
++N+ E QKE+ D +A++ SL +S K D +K L+E ++ ++
Sbjct: 905 EHENLKPLLE-----QKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKE 959
Query: 300 AKSREWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEK---- 355
K +E + ++ + ++ + +E ++K+E ++ + D +++ L +
Sbjct: 960 CKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESY 1019
Query: 356 ---LLRSEESVSRLPEEIRR-------LEEELRQLKSDSHGPKEDGGFRHSEAFEALQQK 405
LL E+ +L E R +E+ RQL++ + + E L +
Sbjct: 1020 KNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDN-----EDLLAR 1074
Query: 406 SQGLDSRLQHVEDGVLSMQVASARQTESLES-LLSKSQEHEQRLAALQGRLEGLGSSEAD 464
+ L S + +E +L +Q A A + LE+ L K Q+ ++
Sbjct: 1075 IETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEH----------------- 1117
Query: 465 QDGLASTVRSLGETQLVLYGDVEELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQAARL 524
A+TV L E Q+ L + ++L++++ EL L K Q TL++ + A RL
Sbjct: 1118 ----ATTVNELEELQVQLQKEKKQLQKTMQEL-----ELVKKDAQQTTLMNMEIADYERL 1168
Query: 525 PPQDFLDRLSSLDNLKASVSQVEADLKMLRTAVDSLVAYSVKIETNENNLESAKGLLDDL 584
+ L N + +E ++K+ + ++L + +L+S+ ++
Sbjct: 1169 ----MKELNQKLTNKNNKIEDLEQEIKIQKQKQETL-------QEEITSLQSSVQQYEEK 1217
Query: 585 RNDLDRLFVKVEK 597
+ +L VK +K
Sbjct: 1218 NTKIKQLLVKTKK 1230
Score = 57.0 bits (136), Expect = 5e-08
Identities = 82/459 (17%), Positives = 184/459 (40%), Gaps = 44/459 (9%)
Query: 133 EVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVKQ 192
+ + + ++D + E L + +E ++ +Q + L + + +++ K
Sbjct: 1060 QCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHAT 1119
Query: 193 GESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDNI 252
+E+ + LQK + ++ K + + V KDA++ T +N I
Sbjct: 1120 TVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQ-----------------TTLMNMEI 1162
Query: 253 AIFTEVQKRSQKEINDMKAKVASLE-ESEGNKQDLKALKEAVKEIQTSAKSREWDMEALR 311
A + + K +++ + K+ LE E + KQ + L+E + +Q+S + E
Sbjct: 1163 ADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYE------- 1215
Query: 312 STLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSRLPEEIR 371
+ T++++L+ +++ A + A+T+ L LQA L+ E S+ E+
Sbjct: 1216 --------EKNTKIKQLLVKTKKELADSKQAETDHLILQA----SLKGELEASQQQVEVY 1263
Query: 372 RLE-EELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQVASARQ 430
+++ E+ K H + +H A QQ+ L + + + Q +
Sbjct: 1264 KIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAK----AEQATVTSE 1319
Query: 431 TESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVR-SLGETQLVLYGDVEEL 489
ES + + + ++ + Q EG + L ++ L ++Q L +V EL
Sbjct: 1320 FESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSEL 1379
Query: 490 KRSVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLSSLDNLKASVSQVEAD 549
+ E + +E K+ ++ + ++ + + + ++ + + + SQ E
Sbjct: 1380 QTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVL 1439
Query: 550 LKMLRTAVDSLVAYSVK-IETNENNLESAKGLLDDLRND 587
R V L K +ET + L + L L+N+
Sbjct: 1440 RNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNE 1478
Score = 53.1 bits (126), Expect = 7e-07
Identities = 99/465 (21%), Positives = 201/465 (43%), Gaps = 52/465 (11%)
Query: 132 EEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSL-QATFGTFESILRSSQHKQD-LTEKA 189
+E++ ++ + + L +Q E+K + Q T + + S Q + D L +A
Sbjct: 1188 QEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQA 1247
Query: 190 VKQGESEVSRISEVLQKLQNEILKDLSDGIHV-VKDARERDFTSLENTVEERLTELTKSI 248
+GE E S+ + K+Q + IH +K + E+ +L + ++R+T L +
Sbjct: 1248 SLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTL-SAYQQRVTALQEEC 1306
Query: 249 N----DNIAIFTEVQK---RSQKEINDMKAKVASLEESEGNKQDLKALKEAVKEIQTSAK 301
+ + +E + R + K K S E+EG KQ+ + L+ + +++ +
Sbjct: 1307 RAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQ 1366
Query: 302 SREWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSE- 360
+ +++ S LQT++S+ T + + QE + KEA E+L +++SE
Sbjct: 1367 DSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVS-KEAELREKLCSIQSENMMMKSEH 1425
Query: 361 -ESVSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDG 419
++VS+L + L R H +E H + E LQQ+ ++++L +++
Sbjct: 1426 TQTVSQLTSQNEVLRNSFRD--QVRHLQEE-----HRKTVETLQQQLSKMEAQLFQLKNE 1478
Query: 420 VLSMQVASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQ 479
+ S++Q SL++L E+R L L+ + + +G+ +T
Sbjct: 1479 PTTRSPVSSQQ--SLKNL------RERRNTDLP-LLDMHTVTREEGEGMETT-------- 1521
Query: 480 LVLYGDVEELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLS----S 535
D E SV + +SL+++ T L + A ++ + +LS S
Sbjct: 1522 -----DTE----SVSSASTYTQSLEQLLNSPETKL-EPPLWHAEFTKEELVQKLSSTTKS 1571
Query: 536 LDNLKASVSQVEADLKMLRTAVDSLVAYSVKIETNENNLESAKGL 580
D+L + + EA +L + L + ++E N+ +SA L
Sbjct: 1572 ADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQEREKSAANL 1616
Score = 48.1 bits (113), Expect = 2e-05
Identities = 102/474 (21%), Positives = 186/474 (39%), Gaps = 97/474 (20%)
Query: 187 EKAVKQGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLT---- 242
E +K+ ES+ S + + + + N LK D H+ KD + LE + E L
Sbjct: 338 EDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHI-KDEFFHEREDLEFKINELLLAKEE 396
Query: 243 -----ELTKS----INDNIAIFTEVQKRSQKEINDMKAKVAS------LEESEGNKQ--- 284
E KS +N E R + + + K S L +SE K
Sbjct: 397 QGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLM 456
Query: 285 -DLKALKEAVKEIQTSAKSREWDMEALRSTLQTMESDIYTEV----RELVSLKQEQ---- 335
+++ LKE + +Q + + E+LR ++ +++++ +E S+KQ+Q
Sbjct: 457 FEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDV 516
Query: 336 ---QAFKEAADTERLAL-------QALTEKLLRSEESVSRLPEEIRRLEEE--------- 376
Q A TE+ AL Q EKLL +E V L I+ L+E+
Sbjct: 517 HELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLS 576
Query: 377 -----LRQLKSDSHGPKED---------GGFRHSEAFEALQQKSQGLDSRL-QHVEDGV- 420
L++L+ + E+ + F ++ + L L + VE +
Sbjct: 577 QRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQ 636
Query: 421 --LSMQVASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGET 478
++ T LE L + +++Q+L L +++ L D++ L++ V+SL E
Sbjct: 637 YNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSE---DKEVLSAEVKSLYEE 693
Query: 479 QLVLYGDVEELKRS----------------VGELPSTVESLQKVQEQVHTLLSQDQAQAA 522
L + ++L R + +L ++ + + Q+ ++ LL +Q Q
Sbjct: 694 NNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKL 753
Query: 523 RLPPQ--DFLDRLSSLDNLKASVSQVEADLKMLRTAVDSLVAYSVKIETNENNL 574
+ Q FL + S + S E D+ + AV +A KI + NL
Sbjct: 754 FVKTQLYGFLKEMGS----EVSEDSEEKDVVNVLQAVGESLA---KINEEKCNL 800
>gi|190341068 forkhead-associated (FHA) phosphopeptide binding domain
1 [Homo sapiens]
Length = 1412
Score = 80.1 bits (196), Expect = 5e-15
Identities = 108/509 (21%), Positives = 221/509 (43%), Gaps = 59/509 (11%)
Query: 46 PPAPHPQQHPQQHPQNQAHGKGGHRGGGGGGGKSSSSSSASAAAAAAAASSSASCSRRLG 105
P +P+ Q QQ N A G + G G + + + A A + + A+ R G
Sbjct: 630 PSSPNKDQ-VQQFSGNSAVFTAG-KAAGASGREGEAERGEARARGEAQSQNQATDGREGG 687
Query: 106 RALNFLFYLALVAAAAFSGWCVHHVLEE------------VQQVRRSHQDFSRQREELGQ 153
+AL Y+ A LEE QQ + + ++++ + +
Sbjct: 688 KALEE--YITQERNRA------KETLEEERKRMQELESLLAQQKKALAKSITQEKNRVKE 739
Query: 154 GLQGVEQKVQSLQATFGTFESILRSS-QHKQDLTEKAVKQGESEVSRISEVLQKLQNEIL 212
L+ + +VQ L+ + +L SS H++ ++A++ + +V + L + +
Sbjct: 740 ALEEEQTRVQELEERLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENHLTQQKEISE 799
Query: 213 KDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDNIAIFTEVQKRSQKEI---NDM 269
+++ K+A E++ +++ +E RLT+ + E++ + QKE N +
Sbjct: 800 SNIAYEKRKAKEAMEKEKKKVQD-LENRLTKQKE----------ELELKEQKEDVLNNKL 848
Query: 270 KAKVASLEESEGNK--QDLKALKEAVKEIQTSAKSREWDMEALRSTLQTMESDIYTEVRE 327
+A +EE++ K + LKA A+K +T A ++E ++ + +E + + +
Sbjct: 849 SDALAMVEETQKTKATESLKAESLALKLNETLA-----ELETTKTKMIMVEERLILQQKM 903
Query: 328 LVSLKQEQQA----FKEAADTERLALQALTEKLLRSEESVSRLPEEIRRLEEELRQLKSD 383
+ +L+ EQ++ F+E + ++ + ++ EE + ++ + +++E E+ LK +
Sbjct: 904 VKALQDEQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQHHKKIEGEIATLKDN 963
Query: 384 SHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQVASARQTESLESLLSKSQE 443
PKE+ R + A +S D +H+ D +L+ Q Q E + L E
Sbjct: 964 DPAPKEE---RPQDPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVIMKLRKDLTE 1020
Query: 444 HEQRLAALQGRLEGLGSSEADQDGLASTVRS-----LGETQLVLYGDVEELKRSVGELPS 498
R++ L+G L E +Q+ + +S L E + VE+ R EL +
Sbjct: 1021 AHSRMSDLRGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSLVEKKDR---ELKA 1077
Query: 499 TVESLQKVQEQVHTLLSQDQAQAARLPPQ 527
E+L+ QE+ L+ ++ Q R Q
Sbjct: 1078 LEEALRASQEKHRLQLNTEKEQKPRKKTQ 1106
Score = 62.8 bits (151), Expect = 9e-10
Identities = 115/540 (21%), Positives = 222/540 (41%), Gaps = 106/540 (19%)
Query: 130 VLEEVQQVRRSHQDFSRQREELGQGLQGVEQK-------VQSLQATFGTFESILRSSQHK 182
++E++ QV + +F +++ L + Q K ++ L+ + + ++ ++ S
Sbjct: 520 LIEKITQVTEDNINFQQKKWTLQKETQLSNSKQEETTENIEKLRTSLDSCQACMKISCCS 579
Query: 183 QDLTEKAVKQGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLT 242
DL ++ +VS LQK+ ++L+ + V+ RD L ++ +
Sbjct: 580 HDLKKEVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEVEQLL-RDLGILPSSPNK--- 635
Query: 243 ELTKSINDNIAIFTEVQ------KRSQKEINDMKAK--VASLEESEGNKQDLKALKEAVK 294
+ + + N A+FT + + + E + +A+ S ++ ++ KAL+E +
Sbjct: 636 DQVQQFSGNSAVFTAGKAAGASGREGEAERGEARARGEAQSQNQATDGREGGKALEEYIT 695
Query: 295 EIQTSAKSREWDMEALRSTLQTMESDIYTEVRELV-SLKQEQQAFKEAADTERLALQALT 353
+ + AK +E R +Q +ES + + + L S+ QE+ KEA + E+ +Q L
Sbjct: 696 QERNRAKET---LEEERKRMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQELE 752
Query: 354 EKLLR---------------SEESVSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEA 398
E+L R ++E++ +++ LE L Q K S + EA
Sbjct: 753 ERLARQKEVLESSIAHEKRKAKEALESEKRKVQDLENHLTQQKEISESNIAYEKRKAKEA 812
Query: 399 FEALQQKSQGLDSR---------LQHVEDGVLSMQVASA----------RQTESL--ESL 437
E ++K Q L++R L+ ++ VL+ +++ A + TESL ESL
Sbjct: 813 MEKEKKKVQDLENRLTKQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESL 872
Query: 438 LSKSQEH--------------EQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQLVLY 483
K E E+RL Q ++ L + Q R E +++ Y
Sbjct: 873 ALKLNETLAELETTKTKMIMVEERLILQQKMVKALQDEQESQ-------RHGFEEEIMEY 925
Query: 484 GDVEELKRSVGELPSTVESLQKVQE-------QVHTLLSQDQAQAARLPPQDFLDRLSSL 536
E++K+ + S E LQKV + ++ TL D A P
Sbjct: 926 --KEQIKQHAQTIVSLEEKLQKVTQHHKKIEGEIATLKDNDPAPKEERPQ---------- 973
Query: 537 DNLKASVSQVEADLKMLRTAVDSLVAYSVKIETNE-------NNLESAKGLLDDLRNDLD 589
D L A +++ A +D L+A +I + + +L A + DLR +L+
Sbjct: 974 DPLVAPMTESSAKDMAYEHLIDDLLAAQKEILSQQEVIMKLRKDLTEAHSRMSDLRGELN 1033
Score = 42.7 bits (99), Expect = 0.001
Identities = 93/427 (21%), Positives = 181/427 (42%), Gaps = 78/427 (18%)
Query: 185 LTEKAVKQG------ESEVSRISEVLQKLQNEILKDLSDGIHVVKD----ARERD--FTS 232
L+EK+V +G +E+ ++ Q+ ++EI+ L + + D ++ +D +
Sbjct: 197 LSEKSVAEGIPGAVPPAEIYVEEDLAQQDKDEIILLLGKEVSRLSDYEIESKYKDVIIAN 256
Query: 233 LENTVEERLTELTKSINDNIAIFTEVQKRSQKEINDMKAKVASLEESEGNKQDLKALKEA 292
L+N V EL++ +++ T ++++KEI+ K +V E+ + ++++++LK
Sbjct: 257 LQNEV----AELSQKVSE-----TTTSRQNEKEISQ-KCQVLD-EDIDAKQKEIQSLKSQ 305
Query: 293 VKEIQTSAKSREWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQAL 352
+ +Q + L TL S E+ SLK E + K + +L
Sbjct: 306 ISALQKGYS------KVLCQTLSERNS-------EITSLKNEGENLKRDNAITSGMVSSL 352
Query: 353 TEKLLRSEESVSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSR 412
+ +L +E V +L EE+ L+ + D E G R S E L+Q
Sbjct: 353 QKDILAKDEQVQQLKEEVSHLKSQ----NKDKDHQLEALGSRCSVLKEELKQ-------- 400
Query: 413 LQHVEDGVLSMQVASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTV 472
ED ++ A Q + L+ ++ Q+ E+ + L+ L S +Q ++ T+
Sbjct: 401 ----EDAHRELREA---QEKELKLCKTQIQDMEKEMKKLRAELR---KSCTEQSVISRTL 450
Query: 473 RSLGETQLVLYGDVEE---LKRSVGELPSTVE-SLQKVQEQVHTLLSQ-DQAQAARLPPQ 527
R + + L D + +G S ++ +L++ Q+ SQ +A R P
Sbjct: 451 REKSKVEEKLQEDSRRKLLQLQEMGNRESVIKINLERAVGQLEHFRSQVIKATYGRAKP- 509
Query: 528 DFLDRLSSLDNLKASVSQVEAD-----LKMLRTAVDSLVAYSVKIETNENNLESAKGLLD 582
F D+ + L ++QV D K ++ ++ S + ET EN ++
Sbjct: 510 -FRDKPVTDQQLIEKITQVTEDNINFQQKKWTLQKETQLSNSKQEETTEN--------IE 560
Query: 583 DLRNDLD 589
LR LD
Sbjct: 561 KLRTSLD 567
Score = 42.4 bits (98), Expect = 0.001
Identities = 37/194 (19%), Positives = 86/194 (44%), Gaps = 20/194 (10%)
Query: 191 KQGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSIND 250
K G+ +V+ E+ +KL ++ K L +++ + L E++ +L
Sbjct: 1229 KSGKMDVAEALELSEKLYLDMSKTLGSLMNIKNMSGHVSMKYLSRQEREKVNQLR----- 1283
Query: 251 NIAIFTEVQKRSQKEINDMKAKVASLEESEGNKQDLKALKEAVKEIQTSAKSREWDMEAL 310
Q++++ + K+ L+ G K++L L+ K+++ +S+ +E
Sbjct: 1284 ------------QRDLDLVFDKITQLKNQLGRKEEL--LRGYEKDVEQLRRSKV-SIEMY 1328
Query: 311 RSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSRLPEEI 370
+S + +E DIY E E LK+ + + E+ +A+ ++ + + ++ ++ +E
Sbjct: 1329 QSQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRINRAIRQQKVGTRKASLKMDQER 1388
Query: 371 RRLEEELRQLKSDS 384
L +E S S
Sbjct: 1389 EMLRKETSSKSSQS 1402
>gi|70166580 GRINL1A upstream protein isoform 7 [Homo sapiens]
Length = 466
Score = 79.7 bits (195), Expect = 7e-15
Identities = 83/368 (22%), Positives = 155/368 (42%), Gaps = 14/368 (3%)
Query: 137 VRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVKQGESE 196
VRRS Q+ ++ G +++++ ++ T E + + D + ++Q E
Sbjct: 76 VRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQE 135
Query: 197 VSRISEVLQKLQNEILKDLS--DGIHVVKDARERDFTSLENTVEERLTELTKSINDNIAI 254
+S + L+N I S D + + A D L+ T+ + E +I D I
Sbjct: 136 LSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLE-NSNIKDQIR- 193
Query: 255 FTEVQKRSQKEINDMKAKVASLEESEGNKQDLKALKEAVKEIQTSAKSREWDMEALRSTL 314
+Q+ + ++ ++ K LE ++ Q LK E+ +E RE +
Sbjct: 194 --NLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVM-REMTKKLYSQYE 250
Query: 315 QTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSRLPEEIRRLE 374
+ ++ + E +L +E +F +A + +QA L ++ + L I R+E
Sbjct: 251 EKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERME 310
Query: 375 EELRQLKSD--SHGPKEDGGFRHS--EAFEALQQKSQGLDSRLQHVEDGVLSMQVASARQ 430
+E QL+ H + G S E ++ L++ S L R++H++D V Q +
Sbjct: 311 KERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQM 370
Query: 431 TESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQLVLYGDVEELK 490
E +ESL K Q+ + + L LE + E + + L S + L ETQ + E+
Sbjct: 371 VEEIESLKKKLQQKQLLILQL---LEKISFLEGENNELQSRLDYLTETQAKTEVETREIG 427
Query: 491 RSVGELPS 498
LPS
Sbjct: 428 VGCDLLPS 435
Score = 42.4 bits (98), Expect = 0.001
Identities = 60/355 (16%), Positives = 148/355 (41%), Gaps = 38/355 (10%)
Query: 258 VQKRSQKEINDMKAKVASLEESEGNKQDLKALKEAVKEIQTSAKSREWDMEALRSTLQTM 317
V +RS + N K V + K+++ +K+ ++ K D + +R ++ +
Sbjct: 75 VVRRSDQ--NQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQL 132
Query: 318 ESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSRLPEEIRRLEEEL 377
++ + L+ Q A D AL + ++++ + E +++++
Sbjct: 133 TQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQI 192
Query: 378 RQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQVASARQT--ESLE 435
R L+ + + + L++K + L+ + VE+ +L M+V S+++ E +
Sbjct: 193 RNLQQT-----------YEASMDKLREKQRQLE--VAQVENQLLKMKVESSQEANAEVMR 239
Query: 436 SLLSKS-QEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQLVLYG---DVEELKR 491
+ K ++E++L Q + EA + S ++++ E + +EE +
Sbjct: 240 EMTKKLYSQYEEKLQEEQRKHSA--EKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQ 297
Query: 492 SVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLSSLDNLKASVSQ------ 545
+GEL +E ++K + Q+ L + + + + +R L+ AS+ +
Sbjct: 298 RIGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLD 357
Query: 546 --VEADLKMLRTAVDSLVAYSVKIETNE-------NNLESAKGLLDDLRNDLDRL 591
V K ++ V+ + + K++ + + +G ++L++ LD L
Sbjct: 358 DMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYL 412
>gi|70166430 GRINL1A combined protein isoform 2 [Homo sapiens]
Length = 445
Score = 78.2 bits (191), Expect = 2e-14
Identities = 82/367 (22%), Positives = 154/367 (41%), Gaps = 14/367 (3%)
Query: 137 VRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVKQGESE 196
VRRS Q+ ++ G +++++ ++ T E + + D + ++Q E
Sbjct: 76 VRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQE 135
Query: 197 VSRISEVLQKLQNEILKDLS--DGIHVVKDARERDFTSLENTVEERLTELTKSINDNIAI 254
+S + L+N I S D + + A D L+ T+ + E +I D I
Sbjct: 136 LSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLE-NSNIKDQIR- 193
Query: 255 FTEVQKRSQKEINDMKAKVASLEESEGNKQDLKALKEAVKEIQTSAKSREWDMEALRSTL 314
+Q+ + ++ ++ K LE ++ Q LK E+ +E RE +
Sbjct: 194 --NLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVM-REMTKKLYSQYE 250
Query: 315 QTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSRLPEEIRRLE 374
+ ++ + E +L +E +F +A + +QA L ++ + L I R+E
Sbjct: 251 EKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERME 310
Query: 375 EELRQLKSD--SHGPKEDGGFRHS--EAFEALQQKSQGLDSRLQHVEDGVLSMQVASARQ 430
+E QL+ H + G S E ++ L++ S L R++H++D V Q +
Sbjct: 311 KERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQM 370
Query: 431 TESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQLVLYGDVEELK 490
E +ESL K Q+ + + L LE + E + + L S + L ETQ + E+
Sbjct: 371 VEEIESLKKKLQQKQLLILQL---LEKISFLEGENNELQSRLDYLTETQAKTEVETREIG 427
Query: 491 RSVGELP 497
LP
Sbjct: 428 VGCDLLP 434
Score = 42.4 bits (98), Expect = 0.001
Identities = 60/355 (16%), Positives = 148/355 (41%), Gaps = 38/355 (10%)
Query: 258 VQKRSQKEINDMKAKVASLEESEGNKQDLKALKEAVKEIQTSAKSREWDMEALRSTLQTM 317
V +RS + N K V + K+++ +K+ ++ K D + +R ++ +
Sbjct: 75 VVRRSDQ--NQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQL 132
Query: 318 ESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSRLPEEIRRLEEEL 377
++ + L+ Q A D AL + ++++ + E +++++
Sbjct: 133 TQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQI 192
Query: 378 RQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQVASARQT--ESLE 435
R L+ + + + L++K + L+ + VE+ +L M+V S+++ E +
Sbjct: 193 RNLQQT-----------YEASMDKLREKQRQLE--VAQVENQLLKMKVESSQEANAEVMR 239
Query: 436 SLLSKS-QEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQLVLYG---DVEELKR 491
+ K ++E++L Q + EA + S ++++ E + +EE +
Sbjct: 240 EMTKKLYSQYEEKLQEEQRKHSA--EKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQ 297
Query: 492 SVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLSSLDNLKASVSQ------ 545
+GEL +E ++K + Q+ L + + + + +R L+ AS+ +
Sbjct: 298 RIGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLD 357
Query: 546 --VEADLKMLRTAVDSLVAYSVKIETNE-------NNLESAKGLLDDLRNDLDRL 591
V K ++ V+ + + K++ + + +G ++L++ LD L
Sbjct: 358 DMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYL 412
>gi|70166414 GRINL1A combined protein isoform 1 [Homo sapiens]
Length = 550
Score = 78.2 bits (191), Expect = 2e-14
Identities = 82/367 (22%), Positives = 154/367 (41%), Gaps = 14/367 (3%)
Query: 137 VRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVKQGESE 196
VRRS Q+ ++ G +++++ ++ T E + + D + ++Q E
Sbjct: 76 VRRSDQNQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQE 135
Query: 197 VSRISEVLQKLQNEILKDLS--DGIHVVKDARERDFTSLENTVEERLTELTKSINDNIAI 254
+S + L+N I S D + + A D L+ T+ + E +I D I
Sbjct: 136 LSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLE-NSNIKDQIR- 193
Query: 255 FTEVQKRSQKEINDMKAKVASLEESEGNKQDLKALKEAVKEIQTSAKSREWDMEALRSTL 314
+Q+ + ++ ++ K LE ++ Q LK E+ +E RE +
Sbjct: 194 --NLQQTYEASMDKLREKQRQLEVAQVENQLLKMKVESSQEANAEVM-REMTKKLYSQYE 250
Query: 315 QTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSRLPEEIRRLE 374
+ ++ + E +L +E +F +A + +QA L ++ + L I R+E
Sbjct: 251 EKLQEEQRKHSAEKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQRIGELDRLIERME 310
Query: 375 EELRQLKSD--SHGPKEDGGFRHS--EAFEALQQKSQGLDSRLQHVEDGVLSMQVASARQ 430
+E QL+ H + G S E ++ L++ S L R++H++D V Q +
Sbjct: 311 KERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQM 370
Query: 431 TESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQLVLYGDVEELK 490
E +ESL K Q+ + + L LE + E + + L S + L ETQ + E+
Sbjct: 371 VEEIESLKKKLQQKQLLILQL---LEKISFLEGENNELQSRLDYLTETQAKTEVETREIG 427
Query: 491 RSVGELP 497
LP
Sbjct: 428 VGCDLLP 434
Score = 42.4 bits (98), Expect = 0.001
Identities = 60/355 (16%), Positives = 148/355 (41%), Gaps = 38/355 (10%)
Query: 258 VQKRSQKEINDMKAKVASLEESEGNKQDLKALKEAVKEIQTSAKSREWDMEALRSTLQTM 317
V +RS + N K V + K+++ +K+ ++ K D + +R ++ +
Sbjct: 75 VVRRSDQ--NQQKEMVVYGWSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQL 132
Query: 318 ESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSRLPEEIRRLEEEL 377
++ + L+ Q A D AL + ++++ + E +++++
Sbjct: 133 TQELSVSHAQQEYLENHIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQI 192
Query: 378 RQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQVASARQT--ESLE 435
R L+ + + + L++K + L+ + VE+ +L M+V S+++ E +
Sbjct: 193 RNLQQT-----------YEASMDKLREKQRQLE--VAQVENQLLKMKVESSQEANAEVMR 239
Query: 436 SLLSKS-QEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQLVLYG---DVEELKR 491
+ K ++E++L Q + EA + S ++++ E + +EE +
Sbjct: 240 EMTKKLYSQYEEKLQEEQRKHSA--EKEALLEETNSFLKAIEEANKKMQAAEISLEEKDQ 297
Query: 492 SVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLSSLDNLKASVSQ------ 545
+GEL +E ++K + Q+ L + + + + +R L+ AS+ +
Sbjct: 298 RIGELDRLIERMEKERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLD 357
Query: 546 --VEADLKMLRTAVDSLVAYSVKIETNE-------NNLESAKGLLDDLRNDLDRL 591
V K ++ V+ + + K++ + + +G ++L++ LD L
Sbjct: 358 DMVHCQQKKVKQMVEEIESLKKKLQQKQLLILQLLEKISFLEGENNELQSRLDYL 412
>gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapiens]
Length = 1478
Score = 78.2 bits (191), Expect = 2e-14
Identities = 107/507 (21%), Positives = 210/507 (41%), Gaps = 63/507 (12%)
Query: 132 EEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTE---- 187
+E+Q V +Q + + L Q ++Q+ ++Q + + E+ S +H D E
Sbjct: 623 KELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLL 682
Query: 188 ---KAVKQGESEVSRISEVLQKLQNEI--LKDLSDGIHVVKDARERDFTSLENTVEER-- 240
KA + +++++ +LQ + E L++ + + +AR R+ +LE+ +++
Sbjct: 683 AVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRALESQCQQQTQ 742
Query: 241 LTELTKSINDNIAIFTEVQKRSQKEINDMKAKVASLEESEGNKQDLKALKEAVKEIQTSA 300
L E+ + + +++ + A LE +G Q L+A V ++Q
Sbjct: 743 LIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQA---QVVDLQAKM 799
Query: 301 KSREWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQ----ALTEKL 356
++ D + ++S L E+ + + LK++ +A A E L AL E+
Sbjct: 800 RAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGALQEE- 858
Query: 357 LRSEESVSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHV 416
R++E+ R EE+R L+EEL Q K S E+ H+E E L + +
Sbjct: 859 -RADEAQQR-EEELRALQEELSQAKCSS----EEAQLEHAELQEQLHRAN---------T 903
Query: 417 EDGVLSMQVASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLG 476
+ L +QV + + K + E A+Q + ++ +++GL V L
Sbjct: 904 DTAELGIQVCALT--------VEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQ 955
Query: 477 ETQLVLYGDVEELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQ---DFLDRL 533
+ + L ++ K + G LP L + +++ +L + L Q + +D
Sbjct: 956 QEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQ 1015
Query: 534 SSLDN-------LKASVSQVEADLKMLRTAVDSLVAYSV----KIETNENNLESAKGLL- 581
S L N L+ + + L+ AV+ L A K+ N+L + +
Sbjct: 1016 SRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAML 1075
Query: 582 ------DDLRNDLDRLFVKVEKIHEKV 602
LR DL+R ++EK K+
Sbjct: 1076 RKDKEGAALREDLERTQKELEKATTKI 1102
Score = 57.8 bits (138), Expect = 3e-08
Identities = 94/484 (19%), Positives = 205/484 (42%), Gaps = 53/484 (10%)
Query: 126 CVHHVLEEVQQVRRSHQDFSRQREELGQGLQ-GVEQKVQSLQATFGTFESILRSSQHKQD 184
C+ L++ +V ++ Q+ ++ + QGL+ G +K + ES+L+ + +
Sbjct: 293 CLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQPLAQELE 352
Query: 185 LTEKAVKQGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTEL 244
T ++ + ++ L Q + +D K +E + + + + EL
Sbjct: 353 ATRDSLDKKNQHLASFPGWLAMAQQK-----ADTASDTKGRQE----PIPSDAAQEMQEL 403
Query: 245 TKSINDNIAIFTEVQKRSQKEINDMKAKVASLEESEGNKQDLKALKEAVKEIQTSAKSRE 304
+ + T+V++ ++++ ++ V L+ E + L+ L + + +Q +
Sbjct: 404 GEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKG 463
Query: 305 WDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVS 364
+ + L LQ + + + EL L++E++ +E + +++LT +L E ++
Sbjct: 464 QEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLA 523
Query: 365 RLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQ 424
++ + + LEE+ +QL D + L Q+ G+ RL L +
Sbjct: 524 QVSQHVSDLEEQKKQLIQDK---------------DHLSQQ-VGMLERLAGPPGPELPV- 566
Query: 425 VASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQLVLYG 484
+ + E+L + S Q E G E +Q GL L +T++
Sbjct: 567 --AGEKNEALVPVNSSLQ-------------EAWGKPEEEQRGLQEA--QLDDTKVQEGS 609
Query: 485 DVEELKRSVGELPSTVESLQKVQEQVHTLLSQDQA--QAARLPPQDFLDRLSSLDNLKAS 542
EEL+++ EL ++++ + + L QA QA + L+SL+ +AS
Sbjct: 610 QEEELRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQAS 669
Query: 543 V----SQVEADLKMLRTAVDSLVAYSVKIETNENNLESAKGLLDDLRNDLDRLFVKVEKI 598
+ Q+EA L +R A +++ A ++ E L+S +G LR ++++ E
Sbjct: 670 IRHLGDQMEASLLAVRKAKEAMKA---QMAEKEAILQSKEGECQQLREEVEQCQQLAEAR 726
Query: 599 HEKV 602
H ++
Sbjct: 727 HREL 730
Score = 52.4 bits (124), Expect = 1e-06
Identities = 76/392 (19%), Positives = 167/392 (42%), Gaps = 62/392 (15%)
Query: 132 EEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTE--KA 189
EE+ ++RR + ++E L Q ++ + +++Q L+ + + SQH DL E K
Sbjct: 485 EELAELRREKKQQQEEKELLEQEVRSLTRQLQFLET------QLAQVSQHVSDLEEQKKQ 538
Query: 190 VKQGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSIN 249
+ Q + +S+ +L++L +L + E L + S+
Sbjct: 539 LIQDKDHLSQQVGMLERLAGPPGPELP----------------VAGEKNEALVPVNSSLQ 582
Query: 250 DNIAIFTEVQKRSQK-EINDMKAKVASLEESEGNKQDLKALKEAVKEIQTSAKSREWDME 308
+ E Q+ Q+ +++D K + S EE +Q + L++ ++ + + E ++
Sbjct: 583 EAWGKPEEEQRGLQEAQLDDTKVQEGSQEEEL--RQANRELEKELQNVVGRNQLLEGKLQ 640
Query: 309 ALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSRLPE 368
AL++ Q ++ L SL+ EQ + + D +L A
Sbjct: 641 ALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLLA----------------- 683
Query: 369 EIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQVASA 428
+R+ +E ++ ++ EA+ Q +G +L+ + + A
Sbjct: 684 -VRKAKEAMKAQMAEK---------------EAILQSKEGECQQLREEVEQCQQLAEARH 727
Query: 429 RQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQLVLY-GDVE 487
R+ +LES + + + L A +G+ +G+G ++ + +L + QL ++ G+V+
Sbjct: 728 RELRALESQCQQQTQLIEVLTAEKGQ-QGVGPPTDNEARELAAQLALSQAQLEVHQGEVQ 786
Query: 488 ELKRSVGELPSTVESLQKVQEQVHTLLSQDQA 519
L+ V +L + + + Q++V + LS +A
Sbjct: 787 RLQAQVVDLQAKMRAALDDQDKVQSQLSMAEA 818
Score = 40.4 bits (93), Expect = 0.005
Identities = 57/276 (20%), Positives = 122/276 (44%), Gaps = 43/276 (15%)
Query: 134 VQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVKQG 193
VQ+++ + + SR+RE L + + G++Q+ +SLQ ++ S Q +A ++
Sbjct: 930 VQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRA 989
Query: 194 ESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDNIA 253
+S + L L+ ++ ++ D +K+A E + SL +EE+ +L
Sbjct: 990 QSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGE-ECKSLRGQLEEQGRQL--------- 1039
Query: 254 IFTEVQKRSQKEINDMKAKVASLEESEGNKQDLKALKEAVKEIQTSAKSREWDMEALRST 313
+ +++ + +KA A + E L + E Q + ++ + ALR
Sbjct: 1040 ------QAAEEAVEKLKATQADMGEK------LSCTSNHLAECQAAMLRKDKEGAALRED 1087
Query: 314 LQTMESDI---YTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSRLPEEI 370
L+ + ++ T+++E + ++ +E D +K+L + ++R
Sbjct: 1088 LERTQKELEKATTKIQEYYNKLCQEVTNRERND----------QKMLADLDDLNRTK--- 1134
Query: 371 RRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKS 406
+ LEE L +L D +D ++ S+A E Q+ S
Sbjct: 1135 KYLEERLIELLRD-----KDALWQKSDALEFQQKLS 1165
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 77.8 bits (190), Expect = 3e-14
Identities = 99/476 (20%), Positives = 201/476 (42%), Gaps = 72/476 (15%)
Query: 142 QDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVKQGESEVSRIS 201
Q+ S +E+L ++++ SL+ FG R H++++ KA+ ++S+ +
Sbjct: 504 QEISSLQEKLEVTRTDHQREITSLKEHFGA-----REETHQKEI--KALYTATEKLSKEN 556
Query: 202 EVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDNIAIFTEVQKR 261
E L+ K+ SD I + K E S + +EE +K + A F E++ +
Sbjct: 557 ESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQ 616
Query: 262 SQKEINDMKAKVASLEESEGNKQDLKALK-EAVK-EIQTSAKSREWDMEALRSTLQTMES 319
+K D + ++ +L+ + +++ A + EA++ ++ K +E +EA+RS L E
Sbjct: 617 IEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAED 676
Query: 320 DIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSRLPEEIRRLEEELRQ 379
E+ + ++ QE A+ + L+ L K + + +++ EE+L
Sbjct: 677 QHLVEMEDTLNKLQE-------AEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLD 729
Query: 380 L----KSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQVASARQTESLE 435
L K+ S G E + L+Q+ + + +++H+E + ++
Sbjct: 730 LDALRKASSEGKSE---------MKKLRQQLEAAEKQIKHLE-------IEKNAESSKAS 773
Query: 436 SLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQLVLYGDVEELKRSVGE 495
S+ + Q E +L LQ L S V + ET L +++ LK E
Sbjct: 774 SITRELQGRELKLTNLQENL--------------SEVSQVKET---LEKELQILKEKFAE 816
Query: 496 LPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLSSLDNLKASVSQVEADLKMLRT 555
S+Q+ ++ L Q + Q L S L+ L+ +++ +EA +
Sbjct: 817 ASEEAVSVQRSMQETVNKLHQKEEQFNMLS--------SDLEKLRENLADMEAKFREKDE 868
Query: 556 AVDSLVAYSVKIETNENNLESAKG--------LLDDLR---NDLDRLFVKVEKIHE 600
+ L+ K+E + + G + D+LR D++ L +K+ K +E
Sbjct: 869 REEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANE 924
Score = 67.4 bits (163), Expect = 4e-11
Identities = 95/483 (19%), Positives = 212/483 (43%), Gaps = 40/483 (8%)
Query: 132 EEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVK 191
+E+Q ++ + S + + + +Q K+ + F S L + E +
Sbjct: 805 KELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFR 864
Query: 192 QGESEVSRISEVLQKLQN---EILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSI 248
+ + ++ + +KL+N EI+K D + + + E VEE +LTK+
Sbjct: 865 EKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMND-ELRLKERDVEELQLKLTKA- 922
Query: 249 NDNIAIFTEVQKRSQKEINDM--KAKVASLEESEGNKQDLKALKEAVKEIQTSAKSREWD 306
N+N + QK I DM KA+ + E ++ ++++ K L+ + +++ ++
Sbjct: 923 NENASFL-------QKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQ 975
Query: 307 MEALRSTLQTMESDIYTEVRELV-----SLKQEQQAFKEAADTERLALQALTEKLLRSEE 361
+ L++ + S+ T+ E++ +L + K A + LQ L E ++++
Sbjct: 976 CQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADK 1035
Query: 362 S-VSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGL-DSRLQHVEDG 419
+ ++ E+ ++ E++ + K+++ ED + LQ + L ++ L++VE+
Sbjct: 1036 AKAAQTAEDAMQIMEQMTKEKTETLASLED----TKQTNAKLQNELDTLKENNLKNVEEL 1091
Query: 420 VLSMQVASARQ------TESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVR 473
S ++ + + +E+L + + Q+L+ALQ L ++ +
Sbjct: 1092 NKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQ 1151
Query: 474 SLGETQLVLYGDVEELKRS----VGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDF 529
L E + VL + E+K+ + + SLQK LL++ A+ +L +
Sbjct: 1152 KLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVT 1211
Query: 530 LDR--LSSLDNLKASVSQVEADLKMLRTAVDSLVAYSVKIETNENNLESAKGLLDDLRND 587
+ R +S +L + V +E+D L V +L ++++ N+ L S+ G D ++
Sbjct: 1212 VLRGENASAKSLHSVVQTLESDKVKLELKVKNL---ELQLKENKRQLSSSSGNTDTQADE 1268
Query: 588 LDR 590
+R
Sbjct: 1269 DER 1271
Score = 58.5 bits (140), Expect = 2e-08
Identities = 93/476 (19%), Positives = 200/476 (42%), Gaps = 63/476 (13%)
Query: 163 QSLQATFGTFESILRSSQH-KQDLTEKAVKQGE--SEVSRISEVLQKLQNEILKDLSDGI 219
+ + T E++ QH +Q L E+ +++ E S + E+ Q+L
Sbjct: 345 RKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELA----------- 393
Query: 220 HVVKDARERDFTSLENTVEERLTELTKSINDNIAIFTEVQKRSQKEINDMKAKVASLEES 279
+ +D ++ LE +++ T + + + + + ++++ +K + D++ +V EE
Sbjct: 394 -LARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRK-VEDLQFRV---EEE 448
Query: 280 EGNKQDLKAL----KEAVKEIQTSAKSREWDMEALRSTLQT--------MESDIYTEV-- 325
K DL+ K + E++ R ++ LR L++ M + E+
Sbjct: 449 SITKGDLEVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISS 508
Query: 326 -------------RELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSRLPEEIRR 372
RE+ SLK+ A +E E AL TEKL + ES+ E +
Sbjct: 509 LQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANK 568
Query: 373 LEEELRQLKSDSHGPKEDGGFRHSEAFEALQQK-SQGL---DSRLQHVEDGVLSMQVASA 428
++ L E H +A E L+ S+GL + ++ + M++
Sbjct: 569 ENSDVIALWKSK---LETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQ 625
Query: 429 RQTESLESLL-SKSQEHEQRLAALQGRL-EGLGSSEADQDGLASTVRSLGETQLVLYGDV 486
+ E+L++ S+ H + + AL+ +L + + E + + S + + LV ++
Sbjct: 626 HEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLV---EM 682
Query: 487 EELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLSSLDNLKASVSQV 546
E+ + E V+ L+ +Q + + ++L + ++L LD L+ + S+
Sbjct: 683 EDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATE--EKLLDLDALRKASSEG 740
Query: 547 EADLKMLRTAVDSLVAYSVKIETNENNLESAKGLLDDLRNDLDRLFVKVEKIHEKV 602
++++K LR +++ +E E N ES+K + +L +K+ + E +
Sbjct: 741 KSEMKKLRQQLEAAEKQIKHLEI-EKNAESSKA--SSITRELQGRELKLTNLQENL 793
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 77.8 bits (190), Expect = 3e-14
Identities = 99/476 (20%), Positives = 201/476 (42%), Gaps = 72/476 (15%)
Query: 142 QDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVKQGESEVSRIS 201
Q+ S +E+L ++++ SL+ FG R H++++ KA+ ++S+ +
Sbjct: 539 QEISSLQEKLEVTRTDHQREITSLKEHFGA-----REETHQKEI--KALYTATEKLSKEN 591
Query: 202 EVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDNIAIFTEVQKR 261
E L+ K+ SD I + K E S + +EE +K + A F E++ +
Sbjct: 592 ESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQ 651
Query: 262 SQKEINDMKAKVASLEESEGNKQDLKALK-EAVK-EIQTSAKSREWDMEALRSTLQTMES 319
+K D + ++ +L+ + +++ A + EA++ ++ K +E +EA+RS L E
Sbjct: 652 IEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAED 711
Query: 320 DIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSRLPEEIRRLEEELRQ 379
E+ + ++ QE A+ + L+ L K + + +++ EE+L
Sbjct: 712 QHLVEMEDTLNKLQE-------AEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLD 764
Query: 380 L----KSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQVASARQTESLE 435
L K+ S G E + L+Q+ + + +++H+E + ++
Sbjct: 765 LDALRKASSEGKSE---------MKKLRQQLEAAEKQIKHLE-------IEKNAESSKAS 808
Query: 436 SLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQLVLYGDVEELKRSVGE 495
S+ + Q E +L LQ L S V + ET L +++ LK E
Sbjct: 809 SITRELQGRELKLTNLQENL--------------SEVSQVKET---LEKELQILKEKFAE 851
Query: 496 LPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLSSLDNLKASVSQVEADLKMLRT 555
S+Q+ ++ L Q + Q L S L+ L+ +++ +EA +
Sbjct: 852 ASEEAVSVQRSMQETVNKLHQKEEQFNMLS--------SDLEKLRENLADMEAKFREKDE 903
Query: 556 AVDSLVAYSVKIETNENNLESAKG--------LLDDLR---NDLDRLFVKVEKIHE 600
+ L+ K+E + + G + D+LR D++ L +K+ K +E
Sbjct: 904 REEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANE 959
Score = 67.4 bits (163), Expect = 4e-11
Identities = 95/483 (19%), Positives = 212/483 (43%), Gaps = 40/483 (8%)
Query: 132 EEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVK 191
+E+Q ++ + S + + + +Q K+ + F S L + E +
Sbjct: 840 KELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFR 899
Query: 192 QGESEVSRISEVLQKLQN---EILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSI 248
+ + ++ + +KL+N EI+K D + + + E VEE +LTK+
Sbjct: 900 EKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMND-ELRLKERDVEELQLKLTKA- 957
Query: 249 NDNIAIFTEVQKRSQKEINDM--KAKVASLEESEGNKQDLKALKEAVKEIQTSAKSREWD 306
N+N + QK I DM KA+ + E ++ ++++ K L+ + +++ ++
Sbjct: 958 NENASFL-------QKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQ 1010
Query: 307 MEALRSTLQTMESDIYTEVRELV-----SLKQEQQAFKEAADTERLALQALTEKLLRSEE 361
+ L++ + S+ T+ E++ +L + K A + LQ L E ++++
Sbjct: 1011 CQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADK 1070
Query: 362 S-VSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGL-DSRLQHVEDG 419
+ ++ E+ ++ E++ + K+++ ED + LQ + L ++ L++VE+
Sbjct: 1071 AKAAQTAEDAMQIMEQMTKEKTETLASLED----TKQTNAKLQNELDTLKENNLKNVEEL 1126
Query: 420 VLSMQVASARQ------TESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVR 473
S ++ + + +E+L + + Q+L+ALQ L ++ +
Sbjct: 1127 NKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQ 1186
Query: 474 SLGETQLVLYGDVEELKRS----VGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDF 529
L E + VL + E+K+ + + SLQK LL++ A+ +L +
Sbjct: 1187 KLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVT 1246
Query: 530 LDR--LSSLDNLKASVSQVEADLKMLRTAVDSLVAYSVKIETNENNLESAKGLLDDLRND 587
+ R +S +L + V +E+D L V +L ++++ N+ L S+ G D ++
Sbjct: 1247 VLRGENASAKSLHSVVQTLESDKVKLELKVKNL---ELQLKENKRQLSSSSGNTDTQADE 1303
Query: 588 LDR 590
+R
Sbjct: 1304 DER 1306
Score = 58.5 bits (140), Expect = 2e-08
Identities = 107/486 (22%), Positives = 201/486 (41%), Gaps = 71/486 (14%)
Query: 129 HVLE---EVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDL 185
HVLE ++ Q+R + R++ EL L+ ++KV+ LQ ESI + Q
Sbjct: 402 HVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEE-ESITKGDLETQTK 460
Query: 186 TEKAVKQGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEE-RLTEL 244
E A RI E+ Q L E K K RE + T + E+ R+ EL
Sbjct: 461 LEHA---------RIKELEQSLLFEKTK-------ADKLQRELEDTRVATVSEKSRIMEL 504
Query: 245 TKSINDNIAIFTEVQKR--SQKEINDMKAKVASLEESEGNKQDLKALKEAVKEIQTSAKS 302
K + + E+++R S K D+ ++ L+E
Sbjct: 505 EKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQE------------------------ 540
Query: 303 REWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEES 362
+ +L+ L+ +D RE+ SLK+ A +E E AL TEKL + ES
Sbjct: 541 ----ISSLQEKLEVTRTD---HQREITSLKEHFGAREETHQKEIKALYTATEKLSKENES 593
Query: 363 VSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQK-SQGL---DSRLQHVED 418
+ E + ++ L E H +A E L+ S+GL + ++
Sbjct: 594 LKSKLEHANKENSDVIALWKSK---LETAIASHQQAMEELKVSFSKGLGTETAEFAELKT 650
Query: 419 GVLSMQVASARQTESLESLL-SKSQEHEQRLAALQGRL-EGLGSSEADQDGLASTVRSLG 476
+ M++ + E+L++ S+ H + + AL+ +L + + E + + S +
Sbjct: 651 QIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAE 710
Query: 477 ETQLVLYGDVEELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLSSL 536
+ LV ++E+ + E V+ L+ +Q + + ++L + ++L L
Sbjct: 711 DQHLV---EMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATE--EKLLDL 765
Query: 537 DNLKASVSQVEADLKMLRTAVDSLVAYSVKIETNENNLESAKGLLDDLRNDLDRLFVKVE 596
D L+ + S+ ++++K LR +++ +E E N ES+K + +L +K+
Sbjct: 766 DALRKASSEGKSEMKKLRQQLEAAEKQIKHLEI-EKNAESSKA--SSITRELQGRELKLT 822
Query: 597 KIHEKV 602
+ E +
Sbjct: 823 NLQENL 828
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 75.9 bits (185), Expect = 1e-13
Identities = 109/507 (21%), Positives = 212/507 (41%), Gaps = 52/507 (10%)
Query: 121 AFSGWCVHHVLEEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQ 180
A G V Q+V Q + R E+L + +Q Q L+A +++R Q
Sbjct: 499 ALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQ 558
Query: 181 HKQDLTEKAVKQGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEER 240
+ + T + +S + E L+ + E+L+ + + K+ E + ++
Sbjct: 559 RELEETSEETGHWQSMFQKNKEDLRATKQELLQ-----LRMEKEEMEEELGEKIEVLQRE 613
Query: 241 LTELTKSIND--NIAIFTEVQKRSQKEINDMKAKVASLEESEGNKQDLKALKEAVKEIQT 298
L + S D + + + R+Q+E+ +++A+ S +E G +D + K+
Sbjct: 614 LEQARASAGDTRQVEVLKKELLRTQEELKELQAERQS-QEVAGRHRDRELEKQLAVLRVE 672
Query: 299 SAKSREWDME--ALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLAL---QALT 353
+ + RE + + L+ TLQ + D +E K A+ E L +A
Sbjct: 673 ADRGRELEEQNLQLQKTLQQLRQDC-----------EEASKAKMVAEAEATVLGQRRAAV 721
Query: 354 EKLLR-SEESVSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEA-LQQKSQGLDS 411
E LR ++E I LE++L++ + DGG EA EA L+ K Q L++
Sbjct: 722 ETTLRETQEENDEFRRRILGLEQQLKETRG-----LVDGG----EAVEARLRDKLQRLEA 772
Query: 412 RLQHVEDGVLSMQV---ASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQ-DG 467
Q +E+ + + Q + A +LE+ L ++Q RL Q L E Q +
Sbjct: 773 EKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREV 832
Query: 468 LASTVRSLGETQLVLYGDVEELKRSVGEL-PSTVESLQKVQEQVHTLLSQDQAQAARLPP 526
L L E + +L V+ L + + ++ + ++LQ++Q Q+ + + + A
Sbjct: 833 LRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQR 892
Query: 527 QDFLDRLSSLDNLKASVSQVEADLKMLRTAVDSLVA-----------YSVKIETNENNLE 575
Q D S + +S+++ +++ LR A+ + A + +++ E E
Sbjct: 893 Q-AKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAE 951
Query: 576 SAKGLLDDLRNDLDRLFVKVEKIHEKV 602
+ K DD L L KV ++ ++
Sbjct: 952 NKKRSQDDRARQLKGLEEKVSRLETEL 978
Score = 58.5 bits (140), Expect = 2e-08
Identities = 93/471 (19%), Positives = 190/471 (40%), Gaps = 81/471 (17%)
Query: 132 EEVQQVRRSHQDFSRQREE---LGQGLQGVE----QKVQSLQATFGTFESILRSSQHKQD 184
EE + RR +Q +E L G + VE K+Q L+A E L +SQ ++
Sbjct: 730 EENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEG 789
Query: 185 -------LTEKAVKQGESEVSRISEVLQKLQNEILKDLSDGIHVVKDAR---ERDFTSLE 234
E +++ + ++R+ + Q L N L++ V++ + E L+
Sbjct: 790 SLAAAKRALEARLEEAQRGLARLGQEQQTL-NRALEEEGKQREVLRRGKAELEEQKRLLD 848
Query: 235 NTVEERLTELTKSINDNIAIFTEVQ-------KRSQKEINDMKAKV----ASLEESEGN- 282
TV+ EL K D+ ++Q +++++E+ D + + + E++ G
Sbjct: 849 RTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGL 908
Query: 283 ---KQDLKALKEAVKEIQTSAKSREWDMEALRSTLQTMESDIYTE-------VRELVSLK 332
+ +++ L++A++ Q + D E L LQ +E + + R+L L+
Sbjct: 909 SRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLE 968
Query: 333 QEQQAFKEAADTERLALQALTEKLLRSEESVSRLPEEIRRLEEELRQLKSD--------- 383
++ + D E+ ++ LT+++ R + V +L E+ + + L+ D
Sbjct: 969 EKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNK 1028
Query: 384 ---SHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQVASARQTESLESLLSK 440
+ +G + S + L+ ++Q L RLQ E +Q + + ++ L +
Sbjct: 1029 DLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQ 1088
Query: 441 SQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQLVLYGDVEELKRSVGELPSTV 500
++ Q + +D L+ V++L V+E + + L
Sbjct: 1089 IEDERQHV-------------NDQKDQLSLRVKALKR-------QVDEAEEEIERLDGLR 1128
Query: 501 ESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLSSLDNLKASVSQVEADLK 551
+ Q+ E+ H + Q QA+ L + KAS S E+ LK
Sbjct: 1129 KKAQREVEEQHEVNEQLQARIKSLEKDSW---------RKASRSAAESALK 1170
Score = 52.4 bits (124), Expect = 1e-06
Identities = 106/478 (22%), Positives = 196/478 (41%), Gaps = 74/478 (15%)
Query: 144 FSRQREELGQGLQGVEQKVQSLQ----ATFGTFESILRSSQ---------HKQDLTEKAV 190
FSR R+ LQ E+ +S Q F + +LR Q H + +
Sbjct: 263 FSRSRQTQDWVLQSFEEPRRSAQDPTMLQFKSTPDLLRDQQEAAPPGSVDHMKATIYGIL 322
Query: 191 KQGESEVS-----RISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELT 245
++G SE ++S VL+K+Q ++ +S G + + + ++ EL
Sbjct: 323 REGSSESETSVRRKVSLVLEKMQPLVM--VSSG--------STKAVAGQGELTRKVEELQ 372
Query: 246 KSINDNIAIFTEVQKRSQKEINDMKAKVASLEESEGNKQDLKALKEAVKEIQTSAKSREW 305
+ +++ EV+KR + E + + + E++E + + L+ E Q S K +
Sbjct: 373 RKLDE------EVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQ- 425
Query: 306 DMEALRSTLQTMESDIYTEVRELVS-LKQEQ--QAFKEAADTERLALQALTEKLLRSEES 362
+M+ L + + + T+V EL + LK Q + KE + L + L E++L ++
Sbjct: 426 NMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQ- 484
Query: 363 VSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLS 422
R+ E++R E EL LK KE+ R E QQ + + + ++D
Sbjct: 485 --RVEEQLRLRERELTALKG---ALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQD 539
Query: 423 MQVASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQLVL 482
V A + + + +L+ Q + + G + + + +++ L +T + L L L
Sbjct: 540 HAVLEA-ERQKMSALVRGLQRELEETSEETGHWQSM--FQKNKEDLRATKQEL----LQL 592
Query: 483 YGDVEELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLSSLDNLKAS 542
+ EE++ +GE +E LQ+ EQ S + + ++ L L L+A
Sbjct: 593 RMEKEEMEEELGE---KIEVLQRELEQARA--SAGDTRQVEVLKKELLRTQEELKELQAE 647
Query: 543 VS-----------QVEADLKMLRTAVDSLVAYSVKIETNENNLESAKGLLDDLRNDLD 589
++E L +LR D E E NL+ K L LR D +
Sbjct: 648 RQSQEVAGRHRDRELEKQLAVLRVEADR------GRELEEQNLQLQK-TLQQLRQDCE 698
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 74.7 bits (182), Expect = 2e-13
Identities = 104/498 (20%), Positives = 221/498 (44%), Gaps = 79/498 (15%)
Query: 133 EVQQVRRSH----QDFSRQREE-------LGQGLQGVEQKVQSLQATFGTFESILRSSQH 181
++Q +R+ H ++ S Q E+ L + QG+E + L + + S+H
Sbjct: 1193 QIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEH 1252
Query: 182 KQDLTEKAVKQGESEVS-------RISEVLQKLQNEILKDLSDGIHVVKDARE------- 227
K+ + V++ ++VS ++E KLQNE+ D + + + E
Sbjct: 1253 KRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNEL-----DNVSTLLEEAEKKGIKFA 1307
Query: 228 RDFTSLENTVEERLTELTKSINDNIAIFTEVQKRSQKEINDMKAKVASLEESEGNKQDLK 287
+D SLE+ +++ T+ + +Q+ +++++N + +++ LEE +
Sbjct: 1308 KDAASLESQLQD-----TQEL---------LQEETRQKLN-LSSRIRQLEEEK------N 1346
Query: 288 ALKEAVKEIQTSAKSREWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERL 347
+L+E +E + + K+ E + AL+S L + + ++ + SL++ ++ K D E L
Sbjct: 1347 SLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKK--KLLKDAEAL 1404
Query: 348 ALQALTEKLLRSEESVSRLPEEIRRLEEELRQLKSDSHGPKEDGG--FRHSEAFEALQQK 405
+ Q L EK L + +L + RL++EL L D ++ + + F+ L +
Sbjct: 1405 S-QRLEEKAL----AYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAE 1459
Query: 406 SQGLDSRLQHVEDGVLSMQVASARQTE--------SLESLLSKSQEHEQRLAALQGRLEG 457
+ + +R D A AR+ E +LE L +E E++ L+ +E
Sbjct: 1460 EKSISARYAEERD----RAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMED 1515
Query: 458 LGSSEADQDGLASTVRSLGETQLVLYGDVEELKRSVGELPSTVESLQKVQEQVHTLLSQD 517
L SS +D + V L +++ L VEE++ + EL +++ + + ++ +
Sbjct: 1516 LMSS---KDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAM 1572
Query: 518 QAQAAR----LPPQDFLDRLSSLDNLKASVSQVEADLKMLRTAVDSLVAYSVKIETNENN 573
+AQ R Q+ + + ++ +++E + K AV S + ++ E
Sbjct: 1573 KAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQ 1632
Query: 574 LESAKGLLDDLRNDLDRL 591
+E+A D++ L +L
Sbjct: 1633 IEAANKARDEVIKQLRKL 1650
Score = 71.6 bits (174), Expect = 2e-12
Identities = 110/527 (20%), Positives = 220/527 (41%), Gaps = 69/527 (13%)
Query: 134 VQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATF-----------GTFESILRSSQHK 182
++Q+ Q+EE + + +E++V +LQ+ GT ES L ++ K
Sbjct: 1338 IRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIES-LEEAKKK 1396
Query: 183 QDLTEKAVKQGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLT 242
+A+ Q E + + L+K +N + ++L D + V D + + ++LE +++
Sbjct: 1397 LLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDD-LTVDLDHQRQVASNLEKK-QKKFD 1454
Query: 243 ELTKSINDNIAIFTEVQKRSQKEINDMKAKVASL--------EESEGNKQDLKALKEAVK 294
+L A + E + R++ E + + K SL E E ++ K L+ ++
Sbjct: 1455 QLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADME 1514
Query: 295 EIQTSAKSREWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTE 354
++ +S ++ L + + +E + +L L+ E QA ++A + +QA+
Sbjct: 1515 DLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKA 1574
Query: 355 KLLR--------SEESVSRLPEEIRRLEEELRQLKSD-----SHGPKEDGGFRHSEA-FE 400
+ R +EE L +++R LE EL + + K + + EA E
Sbjct: 1575 QFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIE 1634
Query: 401 ALQQKSQGLDSRLQHVEDGVLSMQVASARQTESLESLLSKSQEHEQRLAALQGRL----E 456
A + + +L+ ++ + Q S + + ++S+E E++L +L+ + E
Sbjct: 1635 AANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQE 1694
Query: 457 GLGSS-------EADQDGLASTVRSLGETQLVLYGDVEELKRSVGELPSTVESLQKVQE- 508
L SS E ++D LA + + + L + L+ + +L +E Q E
Sbjct: 1695 ELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMEL 1754
Query: 509 ----------QVHTLLSQDQAQAARLPPQDFLDRLSSLDN--LKASVSQVEADLKMLRTA 556
QV TL ++ A+ + D + N LKA + ++E +K A
Sbjct: 1755 LNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKA 1814
Query: 557 VDSLVAYSVKIETNENNLE-------SAKGLLDDLRNDLDRLFVKVE 596
++ A KI E LE +A L+ L +F++VE
Sbjct: 1815 --TISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVE 1859
Score = 51.6 bits (122), Expect = 2e-06
Identities = 82/398 (20%), Positives = 173/398 (43%), Gaps = 61/398 (15%)
Query: 196 EVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDNIAIF 255
+V+R E LQ E+LK VK+ + T +E +EE + + + + +
Sbjct: 846 QVTRQEEELQAKDEELLK--------VKEKQ----TKVEGELEEMERKHQQLLEEKNILA 893
Query: 256 TEVQKRSQ--KEINDMKAKVASLEESEGNKQDLKALKEAVKEIQTSAKSREWDMEALRST 313
++Q ++ E +M+A++A A K+ ++EI +SR + E
Sbjct: 894 EQLQAETELFAEAEEMRARLA-------------AKKQELEEILHDLESRVEEEEERNQI 940
Query: 314 LQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSRLPEEIRRL 373
LQ + + +++L E+Q +E ++L L+ +T +E + ++ EEI L
Sbjct: 941 LQNEKKKMQAHIQDL-----EEQLDEEEGARQKLQLEKVT-----AEAKIKKMEEEILLL 990
Query: 374 EEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQVASARQTES 433
E++ + + ED S ++K++ L +++++ ++ ++S
Sbjct: 991 EDQNSKFIKEKK-LMEDRIAECSSQLAEEEEKAKNL-AKIRNKQEVMIS----------D 1038
Query: 434 LESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQLVLYGDVEELKRSV 493
LE L K ++ Q L + +L+ G + QD +A + E +L L EEL+ ++
Sbjct: 1039 LEERLKKEEKTRQELEKAKRKLD--GETTDLQDQIAELQAQIDELKLQLAKKEEELQGAL 1096
Query: 494 GELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLSSLDNLKASVSQVEADLKML 553
E+L K ++ + QAQ A L +DF +S + + + +L+ L
Sbjct: 1097 AR--GDDETLHK--NNALKVVRELQAQIAEL-QEDFESEKASRNKAEKQKRDLSEELEAL 1151
Query: 554 RTAVD-----SLVAYSVKIETNENNLESAKGLLDDLRN 586
+T ++ + ++ + + E K L ++ +N
Sbjct: 1152 KTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKN 1189
Score = 48.9 bits (115), Expect = 1e-05
Identities = 43/262 (16%), Positives = 111/262 (42%), Gaps = 13/262 (4%)
Query: 133 EVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVKQ 192
E+++ R S + Q +E + L+ +E ++ LQ + E R ++ ++D +
Sbjct: 1660 ELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITN 1719
Query: 193 GESEVSRISEVLQKLQNEI------LKDLSDGIHVVKDARERDFTSLENTVEERLTELTK 246
S S + + ++L+ I L++ + ++ D + ++ E E +
Sbjct: 1720 SASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSA 1779
Query: 247 SINDNIAIFTEVQKRSQKEINDMKAKVASLEESEGNK--QDLKALKEAVKEIQTSAKSRE 304
+ + A +++ +++ ++KAK+ LE + +K + AL+ + +++ +
Sbjct: 1780 AQKSDNA-----RQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEA 1834
Query: 305 WDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVS 364
+ A ++ E + ++ ++ +KE + ++ L +L +EE +
Sbjct: 1835 KERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEAT 1894
Query: 365 RLPEEIRRLEEELRQLKSDSHG 386
R R+L+ EL + G
Sbjct: 1895 RANASRRKLQRELDDATEANEG 1916
Score = 47.0 bits (110), Expect = 5e-05
Identities = 80/371 (21%), Positives = 161/371 (43%), Gaps = 63/371 (16%)
Query: 130 VLEEVQQVRRSHQDFSRQREELGQGLQGV-------EQKVQSLQATFGTFESILRSSQHK 182
V++++++++ +D+ R+ EE + E+K++SL+A + L SS
Sbjct: 1643 VIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASS--- 1699
Query: 183 QDLTEKAVKQGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLT 242
E+A + E E +L +EI S G + D + R +E R+
Sbjct: 1700 ----ERARRHAEQE-------RDELADEITNSAS-GKSALLDEKRR--------LEARIA 1739
Query: 243 ELTKSIND---NIAIFTEVQKRSQKEINDMKAKVA----SLEESEGNKQDL----KALKE 291
+L + + + N+ + + +++ +++ + A++A + ++S+ +Q L K LK
Sbjct: 1740 QLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKA 1799
Query: 292 AVKEIQTSAKSREWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQA 351
++E++ + KS+ ++T+ +E+ I +L EQ+A KE A +L +
Sbjct: 1800 KLQELEGAVKSK------FKATISALEAKIGQLEEQL-----EQEA-KERAAANKLVRR- 1846
Query: 352 LTEKLLRSEESVSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDS 411
TEK L+ E ++ +E R ++ Q++ + K+ R E E ++
Sbjct: 1847 -TEKKLK--EIFMQVEDERRHADQYKEQMEKANARMKQLK--RQLEEAEEEATRANASRR 1901
Query: 412 RLQHVEDGVLSMQVASARQTESLESLLSKS---QEHEQRLAALQGRLEGLGSSEADQDGL 468
+LQ D +R+ +L++ L + R Q LEG S E D
Sbjct: 1902 KLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLHLEG-ASLELSDDDT 1960
Query: 469 ASTVRSLGETQ 479
S + ETQ
Sbjct: 1961 ESKTSDVNETQ 1971
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 73.2 bits (178), Expect = 7e-13
Identities = 96/484 (19%), Positives = 204/484 (42%), Gaps = 63/484 (13%)
Query: 134 VQQVRRSHQDFSRQREELGQGLQGVEQKVQS---------LQATFGTFESILRSSQHKQD 184
++++++ +Q ELG+ + EQ+ S L++ E + +S QH+
Sbjct: 543 IEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQ 602
Query: 185 LTEKAVKQGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTEL 244
L + V+Q + IL + G+ + A D SL +T + T
Sbjct: 603 LVDSIVRQRD-------------MYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQ 649
Query: 245 TKS-------INDNIAIFTEVQKRSQKEINDMKAKVASLEESEGNKQDLKALKEAVKEIQ 297
T S I AI + + +EI + K + E N+Q L+ L+E V +++
Sbjct: 650 TVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQ-LEKLQEQVTDLR 708
Query: 298 TSAKSREWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLL 357
+ ++ + ++ ++ RE+ SL + Q + + +T+ L
Sbjct: 709 SQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLR 768
Query: 358 RSEESVSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVE 417
+ E ++ L++E LK R S+ E+L + +G + L +++
Sbjct: 769 GANEKLAVAEVRAENLKKEKEMLKLSE--------VRLSQQRESLLAEQRGQNLLLTNLQ 820
Query: 418 --DGVLSMQVASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQD--------- 466
G+L +TE+ + L S+ ++ E ++ L+ +LE +E +Q
Sbjct: 821 TIQGILERS-----ETETKQRLSSQIEKLEHEISHLKKKLE----NEVEQRHTLTRNLDV 871
Query: 467 GLASTVRSLGETQLVLYGDVEE-LKRSVGELPSTVESLQKVQEQVHTLLSQDQAQAARLP 525
L T R L +T+ L+ + +E LK + E+ + + L ++ QV + SQ +
Sbjct: 872 QLLDTKRQL-DTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSN 930
Query: 526 PQDFLDRLSSLDNLKASVSQVEADLKMLRTAVDSLVAYSVKIETNENNLESAKGLLDDLR 585
+D D +S L + V+ ++ + L+T+ ++ Y + + E +L K + +++R
Sbjct: 931 KEDVDDLVSQLRQTEEQVNDLK---ERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVR 987
Query: 586 NDLD 589
+++
Sbjct: 988 KNIE 991
Score = 68.2 bits (165), Expect = 2e-11
Identities = 120/524 (22%), Positives = 228/524 (43%), Gaps = 87/524 (16%)
Query: 131 LEEVQQVRRSHQDFSR----QREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLT 186
L QQ RR Q+ ++ + + + L V++LQA + QH ++ T
Sbjct: 1058 LSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETT 1117
Query: 187 EKAVKQ--------------GESEVSRI---SEVLQKLQNEILKD----LSDGIHVVKDA 225
+KA Q + EVS+ E L+K QN +L D LSD VV
Sbjct: 1118 QKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEK-QNRLLHDQIEKLSD--KVVASV 1174
Query: 226 RERDFTSLENTVEERLTELTKSINDNIAIFTEVQKRSQKEINDMKAKVASLEESEGNKQD 285
+E ++ + L+E KS + I + R +KEI + + +VA + ES +Q
Sbjct: 1175 KE----GVQGPLNVSLSEEGKSQEQILEILRFI--RREKEIAETRFEVAQV-ESLRYRQR 1227
Query: 286 LKALKEAVKEIQTSAKSREWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTE 345
++ L+ ++E+Q S + + E ++ T +TM Q ++ K+ TE
Sbjct: 1228 VELLERELQELQDSLNA---EREKVQVTAKTM--------------AQHEELMKK---TE 1267
Query: 346 RLALQALTEKLLRSEESVSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQK 405
+ + T K+LR E+ RL +++++++ ++R+L+ D P ++ SE LQ +
Sbjct: 1268 TMNVVMETNKMLREEK--ERLEQDLQQMQAKVRKLELDIL-PLQEANAELSEKSGMLQAE 1324
Query: 406 SQGLD---SRLQHVEDGVLSMQVASARQTESLESLLSKSQEHEQRLAALQ---GRLEG-L 458
+ L+ R + ++S Q TE LLS+ + H +R+ L GRL+ +
Sbjct: 1325 KKLLEEDVKRWKARNQHLVSQQ--KDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEI 1382
Query: 459 GSSEADQDGLASTVRSLGETQLVLYGDVEELKR-------SVGELPSTVESLQKVQEQVH 511
S A + ++SL E + + E +++ + E T+ ++K+ +
Sbjct: 1383 ARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYK 1442
Query: 512 TLLSQDQAQAARL---------PPQDFLDRLSSLDNLKASVSQVEADLKMLRTAVDSLVA 562
T + +AQ ++ Q+ + + LK +++Q E K L + V++L
Sbjct: 1443 TQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQK 1502
Query: 563 YSVKIETNENNLE----SAKGLLDDLRNDLDRLFVKVEKIHEKV 602
+ ET NL+ + L LR DL + E++ +++
Sbjct: 1503 TLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQI 1546
Score = 57.0 bits (136), Expect = 5e-08
Identities = 89/425 (20%), Positives = 180/425 (42%), Gaps = 64/425 (15%)
Query: 133 EVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVKQ 192
E + R+ + R+ +EL L +KVQ T E +++ ++ ++ + K
Sbjct: 1220 ESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTE-TMNVVMETNKM 1278
Query: 193 GESEVSRISEVLQKLQ----------------NEILKDLSDGIHVVKDARERDF------ 230
E R+ + LQ++Q N L + S + K E D
Sbjct: 1279 LREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKAR 1338
Query: 231 -TSLENTVEERLTELTKSINDNIAIFTEVQKRSQKEINDMKAKVASLEESEGNKQDL-KA 288
L + ++ TE + + + T+ ++ +EI +KA++A S N Q+L ++
Sbjct: 1339 NQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQS 1398
Query: 289 LKEAVKEIQTSAKSREWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLA 348
LKE + +++T + E ++ L DI +V+ + +K+ + +K T+
Sbjct: 1399 LKEDLNKVRT-------EKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYK----TQYEE 1447
Query: 349 LQALTEKLLRSEESVSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQG 408
L+A +K++ + S +E +E+++LK E + KS+
Sbjct: 1448 LKAQQDKVMETSAQSSGDHQEQHVSVQEMQELK---------------ETLNQAETKSKS 1492
Query: 409 LDSRLQHVEDGVLSMQVASAR----QTESLESLLSKSQEHEQRLAALQGRLEGLGSSEAD 464
L+S++++++ LS + AR QT L+S LS+ ++ Q + +L + + +
Sbjct: 1493 LESQVENLQK-TLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEE 1551
Query: 465 QDGLA-----STVRSLGETQLVLYGDVEELKRSVGELPSTVESLQKVQEQVHTLLSQDQA 519
+ A S + L + L + EELK+ G L + L ++ L SQ +
Sbjct: 1552 KTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDEL---DVRITALKSQYEG 1608
Query: 520 QAARL 524
+ +RL
Sbjct: 1609 RISRL 1613
Score = 43.1 bits (100), Expect = 7e-04
Identities = 55/258 (21%), Positives = 113/258 (43%), Gaps = 38/258 (14%)
Query: 183 QDLTEKAVKQGESEVSRISEVLQKLQNEI--LKDLSDGIHVVKDARERDFTSLENTVEER 240
Q LTE+ + + ++E++R + L QN I LK+ + + K+ ++D + ++E+
Sbjct: 1369 QQLTEE-IGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEK 1427
Query: 241 LTELT--KSINDNIAIFTEVQKRSQKEINDMKAKVAS-LEESEGNKQDLKALKEAVKEIQ 297
+ +T K I E K Q ++ + A+ + +E + Q+++ LKE + + +
Sbjct: 1428 VKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAE 1487
Query: 298 TSAKSREWDMEALRSTLQ---------------------TMESDIYTEVRELVSLKQEQQ 336
T +KS E +E L+ TL + D+ + L+Q+
Sbjct: 1488 TKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQ-- 1545
Query: 337 AFKEAADTERLALQALTEKLLRSEESVSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHS 396
E + R A+ A K+ ++ + +++ + EEL+Q K++ R
Sbjct: 1546 -ITEKEEKTRKAIVAAKSKIAH----LAGVKDQLTKENEELKQRNGALDQQKDELDVR-- 1598
Query: 397 EAFEALQQKSQGLDSRLQ 414
AL+ + +G SRL+
Sbjct: 1599 --ITALKSQYEGRISRLE 1614
Score = 42.0 bits (97), Expect = 0.002
Identities = 56/275 (20%), Positives = 112/275 (40%), Gaps = 24/275 (8%)
Query: 133 EVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVKQ 192
E + + R+++ S++ E L + ++ + +K++ T G + L Q ++ +VK
Sbjct: 123 EKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQ----ASDVSVKY 178
Query: 193 GESEVSRISEVLQKLQ---NEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSIN 249
E + + E+L N LK +D + + + + L+ +E + E+++ +
Sbjct: 179 REKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSR-LE 237
Query: 250 DNIAIFTEVQKRSQKEINDMKAKVASLEESEGNKQDLKALKEAVKEIQTSA--KSREWDM 307
+ + + QK + D+ K+ +E + + ++ K E I+ S KS D
Sbjct: 238 EQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEE-KFHNELNAHIKLSNLYKSAADDS 296
Query: 308 EALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSRLP 367
EA +++ V EL L KEA + + L E ++ +
Sbjct: 297 EA-------KSNELTRAVEELHKL------LKEAGEANKAIQDHLLEVEQSKDQMEKEML 343
Query: 368 EEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEAL 402
E+I RLE+EL K G E A+
Sbjct: 344 EKIGRLEKELENANDLLSATKRKGAILSEEELAAM 378
Score = 41.2 bits (95), Expect = 0.003
Identities = 85/434 (19%), Positives = 180/434 (41%), Gaps = 74/434 (17%)
Query: 189 AVKQGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSI 248
AV Q E + ++++ + +QN++ K L+D ++ + L+ E+ E +
Sbjct: 3 AVLQQVLERTELNKLPKSVQNKLEKFLAD--------QQSEIDGLKGRHEKFKVESEQQ- 53
Query: 249 NDNIAIFTEVQKR---SQKEINDMKAKVASLE-ESEGNKQDLKALKEAVKEIQTSAKSRE 304
+ E++KR SQ+ + + + SL E E LKAL E KE++ +
Sbjct: 54 ------YFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNI 107
Query: 305 WDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKE----------AADTERLALQALTE 354
T + +E++ +R L QE + E ++T + LQ +
Sbjct: 108 AIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLD 167
Query: 355 KLLRSEESV----SRLPEEIRRLEEELRQLKSDSHGPKED----GGFRHSEAFEALQQKS 406
+L S+ SV RL +E L + L ++ ++ G + +E E L+
Sbjct: 168 ELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILE-LKCNL 226
Query: 407 QGLDSRLQHVEDGVLSMQVASARQTESLESLLSKSQEHEQRLAALQG----------RLE 456
+ + +E+ + ++ ++ + +E LL+K +E +++ A+++ +L
Sbjct: 227 ENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLS 286
Query: 457 GLGSSEADQ------------DGLASTVRSLGETQLVLYGDVEELKRSVG----ELPSTV 500
L S AD + L ++ GE + + E+++S E+ +
Sbjct: 287 NLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKI 346
Query: 501 ESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLSSLDNLKASVSQVEADLKMLRTAVDSL 560
L+K E + LLS + + A L ++ L+++ A+V+ K+++ +
Sbjct: 347 GRLEKELENANDLLSATKRKGAILSEEE----LAAMSPTAAAVA------KIVKPGMKLT 396
Query: 561 VAYSVKIETNENNL 574
Y+ +ET + L
Sbjct: 397 ELYNAYVETQDQLL 410
Score = 36.6 bits (83), Expect = 0.068
Identities = 41/181 (22%), Positives = 84/181 (46%), Gaps = 30/181 (16%)
Query: 160 QKVQSLQATFGTFESILRSSQHKQDLTEKAVKQGESEVSRISEVLQKLQNEILKDLSDGI 219
Q++Q L+ T E+ +S + + + +K + + E+E + E +LQ+E+ +
Sbjct: 1474 QEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSR------ 1527
Query: 220 HVVKDARERDFTSLENTVEERLTELTKSINDNIAIFTEVQKRSQKEINDMKAKVASLEES 279
+ +D ++R T EE+L + TE +++++K I K+K+A L
Sbjct: 1528 -LRQDLQDR------TTQEEQLRQQ----------ITEKEEKTRKAIVAAKSKIAHL--- 1567
Query: 280 EGNKQDLKALKEAVKEIQTSAKSREWDME----ALRSTLQTMESDIYTEVRELVSLKQEQ 335
G K L E +K+ + ++ +++ AL+S + S + E+RE EQ
Sbjct: 1568 AGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQERHLEQ 1627
Query: 336 Q 336
+
Sbjct: 1628 R 1628
Score = 36.2 bits (82), Expect = 0.089
Identities = 63/297 (21%), Positives = 127/297 (42%), Gaps = 61/297 (20%)
Query: 349 LQALTEKLLRSEESVSRLPEEIR-RLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQ 407
+ A+ +++L E +++LP+ ++ +LE+ L +S+ G K RH + +Q+
Sbjct: 1 MAAVLQQVLERTE-LNKLPKSVQNKLEKFLADQQSEIDGLKG----RHEKFKVESEQQYF 55
Query: 408 GLDSRLQHVEDGVL-------SMQVASARQTESLESLLSKSQEHE---QRLAALQGRLEG 457
++ RL H ++ ++ S+++ + L++L K++E E R A+Q +
Sbjct: 56 EIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTR 115
Query: 458 LGSS-EADQDGLASTVRSLGETQLVLYGDVEELKRSV-------GELPSTVESLQ----- 504
EA++ L T L + L DV+ L + GEL ++ LQ
Sbjct: 116 TKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVS 175
Query: 505 ------KVQEQVHTLLSQ------------DQAQA-ARLPPQDFLDRLSSLDNLKASVSQ 545
+++++ L SQ D+ A R + L+ +L+N K VS+
Sbjct: 176 VKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSR 235
Query: 546 VEADLKMLRTAVDSLVAYSVKIETNENNLESAKGLLDDLRNDLDRLFVKVEKIHEKV 602
+E + L+T +NE+ + + LL L+ ++ EK H ++
Sbjct: 236 LEEQMNGLKT-------------SNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNEL 279
Score = 30.0 bits (66), Expect = 6.4
Identities = 25/87 (28%), Positives = 36/87 (41%), Gaps = 16/87 (18%)
Query: 6 QRGSKGGHGAASPS-----EKGAHPSGGADDVAKKPPPAPQQPPPPPAPHPQQH--PQ-- 56
Q +G GAA S + PS ++ A + P +P++PP P P H PQ
Sbjct: 2035 QNSGEGNTGAAESSFSQEVSREQQPSSASERQAPRAPQSPRRPPHPLPPRLTIHAPPQEL 2094
Query: 57 -------QHPQNQAHGKGGHRGGGGGG 76
Q + Q+ G+G G GG
Sbjct: 2095 GPPVQRIQMTRRQSVGRGLQLTPGIGG 2121
>gi|157785668 coiled-coil domain containing 39 [Homo sapiens]
Length = 941
Score = 73.2 bits (178), Expect = 7e-13
Identities = 100/533 (18%), Positives = 214/533 (40%), Gaps = 118/533 (22%)
Query: 130 VLEEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFG----TFESILRSSQHKQD- 184
V +E+Q++ ++ + G+ QK+ L+ E+ L S HK
Sbjct: 97 VKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMNWDQQALEAWLEESAHKDSD 156
Query: 185 --LTEKAVKQGESEVSRISEVLQKL-----------QNEILKDLSDGIHVVKDARERDFT 231
+K +Q ++++ ++ L++L NE+ + +S + + K A+ DF
Sbjct: 157 ALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNELTETISAQLELDKAAQ--DFR 214
Query: 232 SLENTVEERLTELTKSIN---------DNIAI-FTEVQKRSQKEINDMKAKVASLEESEG 281
+ N +E + + +I DN A+ +++ ++++ N +K K+ LE G
Sbjct: 215 KIHNERQELIKQWENTIEQMQKRDGDIDNCALELARIKQETREKENLVKEKIKFLESEIG 274
Query: 282 NKQDLKA-------------------------LKEAVKEIQTSAKSREWDMEALRSTLQT 316
N + + LK + ++ + D+EALR +
Sbjct: 275 NNTEFEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISK 334
Query: 317 MESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSRLPEEIRRLEEE 376
++ DI+ E L K + + L+ +TEK + EE + L + ++ E++
Sbjct: 335 IKKDIHEETARLQKTKNHNEII-------QTKLKEITEKTMSVEEKATNLEDMLKEEEKD 387
Query: 377 LRQLKSDSHGPKEDGGFRHSEAFE---------ALQQKSQGLDSRLQHVEDGVLSMQVAS 427
++++ + K G +A E A+ + +G S L+H+ + + +
Sbjct: 388 VKEVDVQLNLIK---GVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFET 444
Query: 428 ARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQLVLYGDVE 487
+Q E + S Q+ E+R++ L+G + E + L +
Sbjct: 445 LKQQEIMYSQDFHIQQVERRMSRLKGEIN-------------------SEEKQALEAKIV 485
Query: 488 ELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLSSLDNLKASVSQVE 547
EL++S+ E ST L+ +++H + L +K + S+
Sbjct: 486 ELRKSLEEKKSTCGLLETQIKKLH----------------------NDLYFIKKAHSKNS 523
Query: 548 ADLKMLRTAVDSLVAYSVKIETNENNLESAKGLLDDLRNDLDRLFVKVEKIHE 600
+ + L T ++ L ++ I+ +E L+ AKG DL + + L ++V++ E
Sbjct: 524 DEKQSLMTKINEL---NLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTRE 573
Score = 46.6 bits (109), Expect = 7e-05
Identities = 90/541 (16%), Positives = 208/541 (38%), Gaps = 120/541 (22%)
Query: 131 LEEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAV 190
L +++ R S QD R+ EE + + ++++ +S+ ++ + + + E
Sbjct: 31 LSKLKDERASLQDELREYEER---INSMTSHFKNVKQELSITQSLCKARERETESEEHFK 87
Query: 191 KQGESEVSRISEVLQKLQNEILKDL----------------------------------- 215
+ E+ R+ + +Q+L+NE+ L
Sbjct: 88 AIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMNWDQQALEAWL 147
Query: 216 -------SDGIHVVKDARERDFTSLENTVE-ERLT------------ELTKSINDNIAI- 254
SD + + K A++ D T++ ERLT ELT++I+ + +
Sbjct: 148 EESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNELTETISAQLELD 207
Query: 255 -----FTEVQKRSQKEINDMKAKVASLEESEGN----KQDLKALKEAVKEIQTSAKSREW 305
F ++ Q+ I + + +++ +G+ +L +K+ +E + K +
Sbjct: 208 KAAQDFRKIHNERQELIKQWENTIEQMQKRDGDIDNCALELARIKQETREKENLVKEKIK 267
Query: 306 DMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSR 365
+E+ E I R+L+ + Q +T R+ L+ + L + +V+R
Sbjct: 268 FLESEIGNNTEFEKRISVADRKLLKCRTAYQDH----ETSRIQLKGELDSL---KATVNR 320
Query: 366 LPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQV 425
++ L + + ++K D H + + + ++ + ++L+ + + +S++
Sbjct: 321 TSSDLEALRKNISKIKKDIH--------EETARLQKTKNHNEIIQTKLKEITEKTMSVE- 371
Query: 426 ASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQLVLYGD 485
+ +LE +L + ++ + + ++G+ +A + L +
Sbjct: 372 ---EKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQE----------------LQTE 412
Query: 486 VEELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLSSLDNLKASVSQ 545
+ K + E+ T SL+ + Q+ L + Q + QDF + Q
Sbjct: 413 TMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDF------------HIQQ 460
Query: 546 VEADLKMLRTAVDS-----LVAYSVKIETNENNLESAKGLLDDLRNDLDRLFVKVEKIHE 600
VE + L+ ++S L A V++ + +S GLL+ L ++K H
Sbjct: 461 VERRMSRLKGEINSEEKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHS 520
Query: 601 K 601
K
Sbjct: 521 K 521
Score = 42.0 bits (97), Expect = 0.002
Identities = 94/475 (19%), Positives = 189/475 (39%), Gaps = 103/475 (21%)
Query: 127 VHHVLEEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLT 186
+H +Q+ + ++ + +E+ + VE+K +L E +L+
Sbjct: 339 IHEETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNL-------EDMLKEE------- 384
Query: 187 EKAVKQGESEVSRISEVL----QKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLT 242
EK VK+ + +++ I VL Q+LQ E +K+ + V E +SL++ L
Sbjct: 385 EKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKA-----VLSEIEGTRSSLKH-----LN 434
Query: 243 ELTKSINDNIAIFTEVQKRSQKEINDMKAKVASLEESEGNKQDLKALKEAVKEIQTSAKS 302
+ ++ E+ I ++ +++ L+ E N ++ +AL+ + E++ S +
Sbjct: 435 HQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLK-GEINSEEKQALEAKIVELRKSLEE 493
Query: 303 REWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEES 362
++ L + ++ + +D+Y K+A Q+L K
Sbjct: 494 KKSTCGLLETQIKKLHNDLY--------------FIKKAHSKNSDEKQSLMTK------- 532
Query: 363 VSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLS 422
++ L I R E+EL + K G K+D +ED +L
Sbjct: 533 INELNLFIDRSEKELDKAK----GFKQD-----------------------LMIEDNLLK 565
Query: 423 MQVASARQT--ESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQL 480
++V R+ E +LS + +Q A++ R E + + + LAS +R + + +
Sbjct: 566 LEVKRTREMLHSKAEEVLSLEKRKQQLYTAMEERTEEI---KVHKTMLASQIRYVDQER- 621
Query: 481 VLYGDVEELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLSSLDNLK 540
E + E S +E L+ E + ++ LPP+ ++ + +K
Sbjct: 622 ------ENISTEFRERLSKIEKLKNRYEILTVVM---------LPPEGEEEKTQAYYVIK 666
Query: 541 ASVSQVEADLKMLRTAVDSLVAYSVKIETNENNLESAKGLLDDLRNDLDRLFVKV 595
A+ + E L+ D L A K E LE+ +L+ N+ + F KV
Sbjct: 667 AAQEKEE-----LQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKV 716
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 72.8 bits (177), Expect = 9e-13
Identities = 103/484 (21%), Positives = 206/484 (42%), Gaps = 78/484 (16%)
Query: 145 SRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVKQGESEVSRISEVL 204
S+ +E GLQ ++K++ LQA E + + + + TEK E+ +SE L
Sbjct: 1093 SKVEDEQTLGLQ-FQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERL 1151
Query: 205 QKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTE-------LTKSINDNIAIFTE 257
++ + + RE +F L +EE + L K D++A E
Sbjct: 1152 EEAGGVTSTQIE-----LNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGE 1206
Query: 258 -------VQKRSQKEINDMKAKV----ASLEESEGNKQDLKALKEAVKEIQTSAKSREWD 306
V+++ +KE ++ K ++ +S+E +K +L+ + +++ + A+ + +
Sbjct: 1207 QIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEE 1266
Query: 307 MEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSRL 366
++ S L T +S + TE EL +E+++ + +L RS+++ ++
Sbjct: 1267 IQRSLSELTTQKSRLQTEAGELSRQLEEKES--------------IVSQLSRSKQAFTQQ 1312
Query: 367 PEEIRR-LEEELRQLKSDSHGPKEDGGFRHS-----EAFEALQQKSQGLDSRLQHVEDGV 420
EE++R LEEE + + +H + RH E +E Q+ L L V
Sbjct: 1313 TEELKRQLEEENKAKNALAHALQSS---RHDCDLLREQYEEEQEGKAELQRALSKANSEV 1369
Query: 421 LSMQVASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQL 480
Q + +T++++ +++E E+ L RL+ SE + + + SL +T+
Sbjct: 1370 A--QWRTKYETDAIQ----RTEELEEAKKKLAQRLQ---DSEEQVEAVNAKCASLEKTKQ 1420
Query: 481 VLYGDVEELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLSSLDNLK 540
L G+VE+L V S +L K Q +L++ + + +
Sbjct: 1421 RLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKC------------------E 1462
Query: 541 ASVSQVEADLKMLRTAVDSLV----AYSVKIETNENNLESAKGLLDDLRNDLDRLFVKVE 596
S +++EA LK R+ L AY ++ E K L ++ + +++ +
Sbjct: 1463 ESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGK 1522
Query: 597 KIHE 600
IHE
Sbjct: 1523 TIHE 1526
Score = 68.6 bits (166), Expect = 2e-11
Identities = 103/487 (21%), Positives = 210/487 (43%), Gaps = 63/487 (12%)
Query: 132 EEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVK 191
EE Q+ + +R+EL + L + Q+ LQ L ++ + D KA
Sbjct: 855 EEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKF 914
Query: 192 QGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDN 251
Q E+ +I EV ++ ++E + + T+ + +E+ +EL K I+D
Sbjct: 915 QLEA---KIKEVTERAEDE-------------EEINAELTAKKRKLEDECSELKKDIDDL 958
Query: 252 IAIFTEVQKR---SQKEINDMKAKVASLEESEGN-KQDLKALKEAVKEIQTSAKSREWDM 307
+V+K ++ ++ ++ +++ L+E+ ++ KAL+EA ++ ++ E +
Sbjct: 959 ELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKV 1018
Query: 308 EALRSTLQTMESDIYTEVREL-VSLKQEQQAFKEAADTERLA---LQALTEKLLRSEESV 363
+L T +E +V +L SL+QE++ + +R L+ E +L E
Sbjct: 1019 NSLNKTKSKLEQ----QVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDK 1074
Query: 364 SRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSM 423
+L E +++ + E QL+S + G Q+K + L +R++ +E+ +
Sbjct: 1075 QQLDERLKKKDFEYCQLQSKVEDEQTLG--------LQFQKKIKELQARIEELEEEI-EA 1125
Query: 424 QVASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGL--------ASTVRSL 475
+ A+ +TE S ++ + L L RLE G + Q L R L
Sbjct: 1126 ERATRAKTEKQRS------DYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDL 1179
Query: 476 GETQLVLYGDVEELKR----SVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLD 531
E L V L++ SV EL +++LQ+V++++ S+ + + D
Sbjct: 1180 EEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEID--------D 1231
Query: 532 RLSSLDNLKASVSQVEADLKMLRTAVDSLVAYSVKIETNENNLESAKGLLDDLRNDLDRL 591
SS++++ S + +E + L + + +I+ + + L + K L +L R
Sbjct: 1232 LSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQ 1291
Query: 592 FVKVEKI 598
+ E I
Sbjct: 1292 LEEKESI 1298
Score = 48.5 bits (114), Expect = 2e-05
Identities = 66/307 (21%), Positives = 131/307 (42%), Gaps = 32/307 (10%)
Query: 143 DFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVKQGESEVSRISE 202
D R +E+L + L VE++ LQA + L + TE+A K E E+ +E
Sbjct: 1660 DALRGQEDLKEQLAIVERRANLLQAEVEELRATL-------EQTERARKLAEQELLDSNE 1712
Query: 203 VLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDNIAIFTEVQKRS 262
+Q L + + + K E D L++ VE+ + + ++++
Sbjct: 1713 RVQLLHTQ-----NTSLIHTKKKLETDLMQLQSEVEDASRDARNA-----------EEKA 1756
Query: 263 QKEINDMKAKVASLEESEGNKQDLKALKEAVKEIQTSAKSR--EWDMEALRSTLQTMESD 320
+K I D L++ + L+ +K+ +++ + R E + AL+ + ++
Sbjct: 1757 KKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQK- 1815
Query: 321 IYTEVREL-VSLKQEQQAFKEAADTERLALQALTEKLLRSEE---SVSRLPEEIRRLEEE 376
+ T +REL L+ EQ+ E+ R + + E +SEE +V RL + + +L+ +
Sbjct: 1816 LETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVK 1875
Query: 377 LRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQVASARQTESLES 436
++ K + E H F Q + + + R E V ++ A R S
Sbjct: 1876 VKSYKRQAEEADEQAN-AHLTKFRKAQHELEEAEERADIAESQVNKLR-AKTRDFTSSRM 1933
Query: 437 LLSKSQE 443
++ +S+E
Sbjct: 1934 VVHESEE 1940
Score = 45.4 bits (106), Expect = 1e-04
Identities = 54/317 (17%), Positives = 128/317 (40%), Gaps = 19/317 (5%)
Query: 283 KQDLKALKEAVKEIQTSAKSREWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAA 342
K++ + K+ + + + K E + L ++ + E L+ ++ +A
Sbjct: 854 KEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAK 913
Query: 343 DTERLALQALTEKLLRSEESVSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEAL 402
++ +TE+ EE + L + R+LE+E +LK D + +
Sbjct: 914 FQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE--------LTLAKV 965
Query: 403 QQKSQGLDSRLQHVEDGVLSMQVASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSE 462
+++ +++++++ + + + A+ T ++L Q+ L A + ++ L ++
Sbjct: 966 EKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTK 1025
Query: 463 ADQDGLASTVRSLGETQLVLYGDVEELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQAA 522
+ + + S E + L D+E KR + L+ QE + L + Q
Sbjct: 1026 SKLEQQVEDLESSLEQEKKLRVDLERNKRKL------EGDLKLAQESILDLENDKQQLDE 1079
Query: 523 RLPPQDF--LDRLSSLDNLKASVSQVEADLKMLRTAVDSLVAYSVKIETNENNLESAKGL 580
RL +DF S +++ + Q + +K L+ ++ L +IE +
Sbjct: 1080 RLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEEL---EEEIEAERATRAKTEKQ 1136
Query: 581 LDDLRNDLDRLFVKVEK 597
D +L+ L ++E+
Sbjct: 1137 RSDYARELEELSERLEE 1153
Score = 39.7 bits (91), Expect = 0.008
Identities = 64/322 (19%), Positives = 138/322 (42%), Gaps = 49/322 (15%)
Query: 284 QDLKALKEAVKEIQTSAKS----REWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFK 339
Q + +E++ IQ + +S + W L ++ + TE +E+ ++K+E Q K
Sbjct: 803 QKMVQRRESIFCIQYNIRSFMNVKHWPWMKLFFKIKPLLKSAETE-KEMATMKEEFQKTK 861
Query: 340 EAADTERLALQALTEKLLRSEESVSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAF 399
++L +SE L E++ L +E L+ E+
Sbjct: 862 --------------DELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCD 907
Query: 400 EALQQKSQGLDSRLQHVEDGVLSMQVASARQTESLESLLSKSQEHEQRLAALQGRLEGLG 459
+ ++ K Q L+++++ V + + +A T L + E ++ + L+ L
Sbjct: 908 QLIKAKFQ-LEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE---LTLA 963
Query: 460 SSEADQDGLASTVRSLGETQLVLYGDVEELKRSVGELPSTVESLQKVQEQVHTLLSQDQA 519
E ++ + V++L E ++ L ++ +L ++LQ+ +Q + D
Sbjct: 964 KVEKEKHATENKVKNLTE-------ELSGLDETIAKLTREKKALQEAHQQ-----ALDDL 1011
Query: 520 QAARLPPQDFLDRLSSLDNLKASVSQVEADLKMLRTAVDSLVAYSVKIETNENNLES--- 576
QA D+++SL+ K S++E ++ L ++++ V +E N+ LE
Sbjct: 1012 QAEE-------DKVNSLNKTK---SKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLK 1061
Query: 577 -AKGLLDDLRNDLDRLFVKVEK 597
A+ + DL ND +L +++K
Sbjct: 1062 LAQESILDLENDKQQLDERLKK 1083
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 71.2 bits (173), Expect = 2e-12
Identities = 105/472 (22%), Positives = 190/472 (40%), Gaps = 34/472 (7%)
Query: 133 EVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVKQ 192
++ ++ + +Q S++ E L + Q+ QSLQ + +++ + E +
Sbjct: 492 KILKMEKENQRLSKKVEILENE---IVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLREN 548
Query: 193 GESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDNI 252
E ++ + + + L N+ + L + +AR +D + E + E + ++
Sbjct: 549 SERQIKILEQENEHL-NQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSK-- 605
Query: 253 AIFTEVQKRS-QKEINDMKAKVASLEESEGNKQDLKALKEAVKEIQTSAKSREWDMEALR 311
E +KR +KE+ K K EE E L+ E +++ T+ K +EAL
Sbjct: 606 ---IEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALE 662
Query: 312 STLQTMESDIYTEVRELVSLK----QEQQAFKEAA--DTERLALQALTEKLLRSEESVSR 365
+E + + L S K Q + KE + D E L L+ E L + +++
Sbjct: 663 QENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQ 722
Query: 366 LPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQV 425
L E + LE E QLK K F+ +E E QGLD Q +Q
Sbjct: 723 LQLENKELESEKEQLKKGLELLK--ASFKKTERLEV---SYQGLDIENQR-------LQK 770
Query: 426 ASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQLVLYGD 485
+ ++ L S+ Q+ E LQ LE L S + L +SL + L D
Sbjct: 771 TLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKD 830
Query: 486 VEELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQ-----DFLDRLSSLDNL- 539
++L++ L E E+ + + + + L + + RL L+
Sbjct: 831 KKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKEN 890
Query: 540 KASVSQVEADLKMLRTAVDSLVAYSVKIETNENNLESAKGLLDDLRNDLDRL 591
K V + D+K L T + LV+ +K + N+LE L+ + + +RL
Sbjct: 891 KELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERL 942
Score = 57.4 bits (137), Expect = 4e-08
Identities = 101/470 (21%), Positives = 196/470 (41%), Gaps = 70/470 (14%)
Query: 133 EVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVKQ 192
E Q+++++ ++ +++ ++L LQ +E + Q+LQ E + SS+ + L EK K
Sbjct: 764 ENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNL---EELKISSKRLEQL-EKENKS 819
Query: 193 GESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDNI 252
E E S++ + ++L+ E + + + A +D T EN V+ I
Sbjct: 820 LEQETSQLEKDKKQLEKENKR-------LRQQAEIKDTTLEENNVK-------------I 859
Query: 253 AIFTEVQKRSQKEINDMKAKVASLEESEGNKQDLKALKEAVKEIQTSAKSREWDMEALRS 312
+ K KEI K L+E E K++ + +K A +I+T RE D+ + +
Sbjct: 860 GNLEKENKTLSKEIGIYKESCVRLKELE--KENKELVKRATIDIKTLVTLRE-DLVSEKL 916
Query: 313 TLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSRLPEEIRR 372
Q M +D+ EL E++ L E+LL E+S +
Sbjct: 917 KTQQMNNDLEKLTHEL----------------EKIGLNK--ERLLHDEQSTD--DSRYKL 956
Query: 373 LEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQVASARQTE 432
LE +L S E ++K L++RL+ E + Q+ +T
Sbjct: 957 LESKLESTLKKS--------------LEIKEEKIAALEARLE--ESTNYNQQLRQELKTV 1000
Query: 433 SLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQLVLYGDVEELKRS 492
K ++ E+R+ + G + + T R L L + + E++R+
Sbjct: 1001 KKNYEALKQRQDEERMVQSSPPISGEDNKWERES--QETTREL----LKVKDRLIEVERN 1054
Query: 493 VGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLSSLDNLKASVSQVEADLKM 552
L + ++L+ +Q+ T + QAQ L Q + L+ ++++ +
Sbjct: 1055 NATLQAEKQALKTQLKQLETQNNNLQAQILALQRQT-VSLQEQNTTLQTQNAKLQVENST 1113
Query: 553 LRTAVDSLVAYSVKIETNENNLESAKGLLDDLRNDLDRLFVKVEKIHEKV 602
L + SL+ + ++ +++LE+ + R DL L+ + K HEK+
Sbjct: 1114 LNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKL 1163
Score = 53.5 bits (127), Expect = 5e-07
Identities = 94/471 (19%), Positives = 190/471 (40%), Gaps = 70/471 (14%)
Query: 133 EVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQ-ATFGTFESILRSSQHKQ-DLTEKAV 190
+ QQ+ + + + E++G + + QS + + ES L S+ K ++ E+ +
Sbjct: 917 KTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKI 976
Query: 191 KQGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERD--------FTSLENTVEERLT 242
E+ + + Q+L+ E LK + +K ++ + + +N E
Sbjct: 977 AALEARLEESTNYNQQLRQE-LKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQ 1035
Query: 243 ELTKSINDNIAIFTEVQKRS---QKEINDMKAKVASLEESEGNKQ-DLKALKE---AVKE 295
E T+ + EV++ + Q E +K ++ LE N Q + AL+ +++E
Sbjct: 1036 ETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQE 1095
Query: 296 IQTSAKSREWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEK 355
T+ +++ ++ STL + + + + +L+ + + E+ ER L++L +
Sbjct: 1096 QNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDS 1155
Query: 356 LLRSEESVSRLPE-------------------------EIRRLEEELRQLKSDSHGPKED 390
L++ E + L E E R LE+ QL G ED
Sbjct: 1156 LIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQK-GQLED 1214
Query: 391 GGF-------------RHSEAFEALQQKSQGLDSRLQHVEDGVLSMQVASARQTESLESL 437
++ E A +K G + RL H +L ++L+SL
Sbjct: 1215 LEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSL 1274
Query: 438 LSKSQEHEQRLAALQGRLEGLGSSEADQDGLAST-VRSLGETQLVLYGDVEELKRSVGEL 496
L+ S+ + RL A +L+ + Q + ST + + E L G++EE R +
Sbjct: 1275 LNNSKLEQTRLEAEFSKLK----EQYQQLDITSTKLNNQCELLSQLKGNLEEENRHL--- 1327
Query: 497 PSTVESLQKVQEQVHTLLSQ--DQAQAARLPPQDFLDRLSSLDNLKASVSQ 545
++ +Q + Q TLL Q + + + ++D+L+ L K + +
Sbjct: 1328 ---LDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEE 1375
Score = 50.1 bits (118), Expect = 6e-06
Identities = 105/509 (20%), Positives = 215/509 (42%), Gaps = 79/509 (15%)
Query: 132 EEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTF-ESILRSSQHKQDLTEKAV 190
+E +++R+ + EE + +E++ ++L G + ES +R + +++ ++ V
Sbjct: 836 KENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKE-NKELV 894
Query: 191 KQGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSIND 250
K+ ++ + + + L +E LK + K E + L +ERL +S +D
Sbjct: 895 KRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLN---KERLLHDEQSTDD 951
Query: 251 NIAIFTEVQKRS--QKEINDMKAKVASLE---ESEGN-----KQDLKALK---EAVKEIQ 297
+ E + S +K + + K+A+LE E N +Q+LK +K EA+K+ Q
Sbjct: 952 SRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQ 1011
Query: 298 T-----------SAKSREWDMEALRSTLQTME-SDIYTEV-RELVSLKQEQQAFKEAADT 344
S + +W+ E+ +T + ++ D EV R +L+ E+QA K T
Sbjct: 1012 DEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALK----T 1067
Query: 345 ERLALQALTEKLLRSEESVSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQ 404
+ L+ L + + L + L+E+ L++ + + + +S++ + Q
Sbjct: 1068 QLKQLETQNNNL---QAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQ 1124
Query: 405 KSQGL--DSRLQHVEDGVLSMQVASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSE 462
+Q L S L++ + V+ ++ E L+SL + ++L L R S
Sbjct: 1125 NAQLLIQQSSLENENESVI-------KEREDLKSLYDSLIKDHEKLELLHERQASEYESL 1177
Query: 463 ADQDGLASTVRSLGETQLVLYGDVEE----LKRSVGELPSTVESLQKVQEQVHTLLSQDQ 518
+ G T++S + V + D+E+ L + G+L +E + KV+++ L +++
Sbjct: 1178 ISKHG---TLKSAHKNLEVEHRDLEDRYNQLLKQKGQLED-LEKMLKVEQEKMLLENKNH 1233
Query: 519 AQAA------------------------RLPPQDFLDRLSSLDNLKASVSQVEADLKMLR 554
A + D + S L+N K +++EA+ L+
Sbjct: 1234 ETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLK 1293
Query: 555 TAVDSLVAYSVKIETNENNLESAKGLLDD 583
L S K+ L KG L++
Sbjct: 1294 EQYQQLDITSTKLNNQCELLSQLKGNLEE 1322
Score = 41.2 bits (95), Expect = 0.003
Identities = 55/260 (21%), Positives = 113/260 (43%), Gaps = 26/260 (10%)
Query: 346 RLALQALTEKLLRSEESVSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQK 405
R L+ TE+LL ++ + ++ E++RL++E L SD+ + + + +AL++K
Sbjct: 264 RQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSAR-----MYRDELDALREK 318
Query: 406 S---QGLDSRLQHVEDGVLSMQVASARQTESLES---LLSKSQEHEQRLAALQGRLEGLG 459
+ L+S + ++ + ++ AR E E LL E +L + R + L
Sbjct: 319 AVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLH 378
Query: 460 SSEADQDGLASTVRSLGETQLVLYGDVEELKRSVGELPSTVESLQK--VQEQVHTLLSQD 517
E + L + + + + + +EEL E T+E QK + E +H +
Sbjct: 379 ELEKENLQLKAKLHDMEMERDMDRKKIEELM----EENMTLEMAQKQSMDESLHLGWELE 434
Query: 518 Q----AQAARLPPQDFLDRLSSLDN-----LKASVSQVEADLKMLRTAVDSLVAYSVKIE 568
Q ++ + P + ++ L + L+ + ++ LRT VDS+ + KI
Sbjct: 435 QISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKIL 494
Query: 569 TNENNLESAKGLLDDLRNDL 588
E + ++ L N++
Sbjct: 495 KMEKENQRLSKKVEILENEI 514
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 71.2 bits (173), Expect = 2e-12
Identities = 105/472 (22%), Positives = 190/472 (40%), Gaps = 34/472 (7%)
Query: 133 EVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVKQ 192
++ ++ + +Q S++ E L + Q+ QSLQ + +++ + E +
Sbjct: 492 KILKMEKENQRLSKKVEILENE---IVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLREN 548
Query: 193 GESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDNI 252
E ++ + + + L N+ + L + +AR +D + E + E + ++
Sbjct: 549 SERQIKILEQENEHL-NQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSK-- 605
Query: 253 AIFTEVQKRS-QKEINDMKAKVASLEESEGNKQDLKALKEAVKEIQTSAKSREWDMEALR 311
E +KR +KE+ K K EE E L+ E +++ T+ K +EAL
Sbjct: 606 ---IEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALE 662
Query: 312 STLQTMESDIYTEVRELVSLK----QEQQAFKEAA--DTERLALQALTEKLLRSEESVSR 365
+E + + L S K Q + KE + D E L L+ E L + +++
Sbjct: 663 QENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQ 722
Query: 366 LPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQV 425
L E + LE E QLK K F+ +E E QGLD Q +Q
Sbjct: 723 LQLENKELESEKEQLKKGLELLK--ASFKKTERLEV---SYQGLDIENQR-------LQK 770
Query: 426 ASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQLVLYGD 485
+ ++ L S+ Q+ E LQ LE L S + L +SL + L D
Sbjct: 771 TLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKD 830
Query: 486 VEELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQ-----DFLDRLSSLDNL- 539
++L++ L E E+ + + + + L + + RL L+
Sbjct: 831 KKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKEN 890
Query: 540 KASVSQVEADLKMLRTAVDSLVAYSVKIETNENNLESAKGLLDDLRNDLDRL 591
K V + D+K L T + LV+ +K + N+LE L+ + + +RL
Sbjct: 891 KELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERL 942
Score = 58.2 bits (139), Expect = 2e-08
Identities = 101/470 (21%), Positives = 197/470 (41%), Gaps = 71/470 (15%)
Query: 133 EVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVKQ 192
E Q+++++ ++ +++ ++L LQ +E + Q+LQ E + SS+ + L EK K
Sbjct: 764 ENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNL---EELKISSKRLEQL-EKENKS 819
Query: 193 GESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDNI 252
E E S++ + ++L+ E + + + A +D T EN V+ I
Sbjct: 820 LEQETSQLEKDKKQLEKENKR-------LRQQAEIKDTTLEENNVK-------------I 859
Query: 253 AIFTEVQKRSQKEINDMKAKVASLEESEGNKQDLKALKEAVKEIQTSAKSREWDMEALRS 312
+ K KEI K L+E E K++ + +K A +I+T RE D+ + +
Sbjct: 860 GNLEKENKTLSKEIGIYKESCVRLKELE--KENKELVKRATIDIKTLVTLRE-DLVSEKL 916
Query: 313 TLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSRLPEEIRR 372
Q M +D+ EL E++ L E+LL E+S + +
Sbjct: 917 KTQQMNNDLEKLTHEL----------------EKIGLNK--ERLLHDEQSTD---DRYKL 955
Query: 373 LEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQVASARQTE 432
LE +L S E ++K L++RL+ E + Q+ +T
Sbjct: 956 LESKLESTLKKS--------------LEIKEEKIAALEARLE--ESTNYNQQLRQELKTV 999
Query: 433 SLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQLVLYGDVEELKRS 492
K ++ E+R+ + G + + T R L L + + E++R+
Sbjct: 1000 KKNYEALKQRQDEERMVQSSPPISGEDNKWERES--QETTREL----LKVKDRLIEVERN 1053
Query: 493 VGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLSSLDNLKASVSQVEADLKM 552
L + ++L+ +Q+ T + QAQ L Q + L+ ++++ +
Sbjct: 1054 NATLQAEKQALKTQLKQLETQNNNLQAQILALQRQT-VSLQEQNTTLQTQNAKLQVENST 1112
Query: 553 LRTAVDSLVAYSVKIETNENNLESAKGLLDDLRNDLDRLFVKVEKIHEKV 602
L + SL+ + ++ +++LE+ + R DL L+ + K HEK+
Sbjct: 1113 LNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKL 1162
Score = 52.0 bits (123), Expect = 2e-06
Identities = 103/508 (20%), Positives = 216/508 (42%), Gaps = 78/508 (15%)
Query: 132 EEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTF-ESILRSSQHKQDLTEKAV 190
+E +++R+ + EE + +E++ ++L G + ES +R + +++ ++ V
Sbjct: 836 KENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKE-NKELV 894
Query: 191 KQGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSIND 250
K+ ++ + + + L +E LK + K E + L +ERL +S +D
Sbjct: 895 KRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLN---KERLLHDEQSTDD 951
Query: 251 NIAIF-TEVQKRSQKEINDMKAKVASLE---ESEGN-----KQDLKALK---EAVKEIQT 298
+ ++++ +K + + K+A+LE E N +Q+LK +K EA+K+ Q
Sbjct: 952 RYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQD 1011
Query: 299 -----------SAKSREWDMEALRSTLQTME-SDIYTEV-RELVSLKQEQQAFKEAADTE 345
S + +W+ E+ +T + ++ D EV R +L+ E+QA K T+
Sbjct: 1012 EERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALK----TQ 1067
Query: 346 RLALQALTEKLLRSEESVSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQK 405
L+ L + + L + L+E+ L++ + + + +S++ + Q
Sbjct: 1068 LKQLETQNNNL---QAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQN 1124
Query: 406 SQGL--DSRLQHVEDGVLSMQVASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEA 463
+Q L S L++ + V+ ++ E L+SL + ++L L R S
Sbjct: 1125 AQLLIQQSSLENENESVI-------KEREDLKSLYDSLIKDHEKLELLHERQASEYESLI 1177
Query: 464 DQDGLASTVRSLGETQLVLYGDVEE----LKRSVGELPSTVESLQKVQEQVHTLLSQDQA 519
+ G T++S + V + D+E+ L + G+L +E + KV+++ L +++
Sbjct: 1178 SKHG---TLKSAHKNLEVEHRDLEDRYNQLLKQKGQLED-LEKMLKVEQEKMLLENKNHE 1233
Query: 520 QAA------------------------RLPPQDFLDRLSSLDNLKASVSQVEADLKMLRT 555
A + D + S L+N K +++EA+ L+
Sbjct: 1234 TVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKE 1293
Query: 556 AVDSLVAYSVKIETNENNLESAKGLLDD 583
L S K+ L KG L++
Sbjct: 1294 QYQQLDITSTKLNNQCELLSQLKGNLEE 1321
Score = 41.2 bits (95), Expect = 0.003
Identities = 55/260 (21%), Positives = 113/260 (43%), Gaps = 26/260 (10%)
Query: 346 RLALQALTEKLLRSEESVSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQK 405
R L+ TE+LL ++ + ++ E++RL++E L SD+ + + + +AL++K
Sbjct: 264 RQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSAR-----MYRDELDALREK 318
Query: 406 S---QGLDSRLQHVEDGVLSMQVASARQTESLES---LLSKSQEHEQRLAALQGRLEGLG 459
+ L+S + ++ + ++ AR E E LL E +L + R + L
Sbjct: 319 AVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLH 378
Query: 460 SSEADQDGLASTVRSLGETQLVLYGDVEELKRSVGELPSTVESLQK--VQEQVHTLLSQD 517
E + L + + + + + +EEL E T+E QK + E +H +
Sbjct: 379 ELEKENLQLKAKLHDMEMERDMDRKKIEELM----EENMTLEMAQKQSMDESLHLGWELE 434
Query: 518 Q----AQAARLPPQDFLDRLSSLDN-----LKASVSQVEADLKMLRTAVDSLVAYSVKIE 568
Q ++ + P + ++ L + L+ + ++ LRT VDS+ + KI
Sbjct: 435 QISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKIL 494
Query: 569 TNENNLESAKGLLDDLRNDL 588
E + ++ L N++
Sbjct: 495 KMEKENQRLSKKVEILENEI 514
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 71.2 bits (173), Expect = 2e-12
Identities = 93/481 (19%), Positives = 207/481 (43%), Gaps = 54/481 (11%)
Query: 127 VHHVLEEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHK-QDL 185
+ V E ++ + + + ++ +L +++ + L+ T E ++++K ++L
Sbjct: 922 IKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNL 981
Query: 186 TEKAVKQGES--EVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTE 243
TE+ E+ ++S+ + LQ+ + L DL ++ + T + +E+++ +
Sbjct: 982 TEEMAGLDETIAKLSKEKKALQETHQQTLDDLQ-----AEEDKVNILTKAKTKLEQQVDD 1036
Query: 244 LTKSINDNIAIFTEVQKRSQKEINDMKAKVASLEESEGNKQDLKALKEAVKEIQTSAKSR 303
L S+ + ++++ +K D+K S + E +KQ L E + ++ S+
Sbjct: 1037 LEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISK 1096
Query: 304 EWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTER----LALQALTEKLLRS 359
D +A+ LQ ++ + EL + ++A + A+ +R L+ ++E+L +
Sbjct: 1097 IEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEA 1156
Query: 360 EESVSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDG 419
+ S E ++ E E ++L+ D E+ +H AL++K + L
Sbjct: 1157 GGATSAQVELNKKREAEFQKLRRD----LEEATLQHEAMVAALRKKHADSMAEL------ 1206
Query: 420 VLSMQVASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQ 479
Q ++L+ + K ++ + L + + D L+S ++ + +
Sbjct: 1207 --------GEQIDNLQRVKQKLEKEKSEL-------------KMETDDLSSNAEAISKAK 1245
Query: 480 LVLYGDVEELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLSSLDNL 539
G++E++ RS L V L+ +E+ L++ AQ ARL + + LD
Sbjct: 1246 ----GNLEKMCRS---LEDQVSELKTKEEEQQRLINDLTAQRARLQTEAG-EYSRQLDEK 1297
Query: 540 KASVSQVEADLKMLRTAVDSLVAYSVKIETNENNLESAKGLLDDLRNDLDRLFVKVEKIH 599
A VSQ+ + ++ L + ++ ET N + L R+D D L + E+
Sbjct: 1298 DALVSQLSRSKQASTQQIEEL-KHQLEEETKAKN--ALAHALQSSRHDCDLLREQYEEEQ 1354
Query: 600 E 600
E
Sbjct: 1355 E 1355
Score = 63.9 bits (154), Expect = 4e-10
Identities = 105/502 (20%), Positives = 211/502 (42%), Gaps = 71/502 (14%)
Query: 134 VQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVKQG 193
V Q+ RS Q ++Q EEL L+ E K ++ A L+SS+H DL + ++
Sbjct: 1301 VSQLSRSKQASTQQIEELKHQLEE-ETKAKNALA------HALQSSRHDCDLLREQYEEE 1353
Query: 194 ESEVSRISEVLQKLQNEI----------------------------LKDLSDGIHVVKD- 224
+ + + L K +E+ L++ + + V
Sbjct: 1354 QEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAK 1413
Query: 225 --ARERDFTSLENTVEERLTELTKSINDNIAIFTEVQKRSQKEINDMKAKVASLE-ESEG 281
+ E+ L+N VE+ + ++ +S N A + Q+ K +++ K K + E E
Sbjct: 1414 CASLEKTKQRLQNEVEDLMLDVERS-NAACAALDKKQRNFDKVLSEWKQKYEETQAELEA 1472
Query: 282 NKQDLKALKEAVKEIQTSAKSREWDMEALR---STLQTMESDIYTEVRELVSLKQEQQAF 338
++++ ++L + +++ + +E LR LQ SD+ ++ E E +
Sbjct: 1473 SQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKI 1532
Query: 339 KEAADTERLALQALTEKLLRSEESVSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEA 398
K+ + E+ +QA E+ +E S+ +I R++ EL Q+KS+ + E
Sbjct: 1533 KKQVEQEKCEIQAALEE---AEASLEHEEGKILRIQLELNQVKSEVDRKIAE----KDEE 1585
Query: 399 FEALQQKSQGLDSRLQHVEDGVLSMQVASARQTESLESLLSKSQ---EHEQRLAALQGRL 455
+ L++ + +Q D + + + R + +E L++ + H RLAA
Sbjct: 1586 IDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAA----- 1640
Query: 456 EGLGSSEADQDGLASTVRSLGETQLVLYGDVEELKRSVGELPSTVESLQKVQEQVHTLLS 515
E L + Q L T L + L G E+LK + + LQ E++ L
Sbjct: 1641 ESLRNYRNTQGILKETQLHLDD---ALRGQ-EDLKEQLAIVERRANLLQAEIEELWATLE 1696
Query: 516 QDQAQAARLPPQDFLD---RLSSLDNLKASV----SQVEADLKMLRTAVDSLVAYSVKIE 568
Q + ++ ++ Q+ LD R+ L S+ ++E D+ L++ V+ ++ S E
Sbjct: 1697 QTE-RSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAE 1755
Query: 569 TN-ENNLESAKGLLDDLRNDLD 589
+ + A + ++L+ + D
Sbjct: 1756 EKAKKAITDAAMMAEELKKEQD 1777
Score = 63.9 bits (154), Expect = 4e-10
Identities = 96/480 (20%), Positives = 201/480 (41%), Gaps = 64/480 (13%)
Query: 132 EEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVK 191
+E+ + + +Q EL + + VEQ+ +QA + E +++
Sbjct: 1510 QEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAAL--------------EEAEASLE 1555
Query: 192 QGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDN 251
E ++ RI L ++++E+ + +++ + D +R+ T + T++ L +S ND
Sbjct: 1556 HEEGKILRIQLELNQVKSEVDRKIAEKDEEI-DQLKRNHTRVVETMQSTLDAEIRSRNDA 1614
Query: 252 IAIFTEVQKRSQKEINDMK-----AKVASLEESEGNKQDLKALKEAVKEIQTSAKSREWD 306
+ V+K+ + ++N+M+ A + E + LKE + + + +E D
Sbjct: 1615 L----RVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQE-D 1669
Query: 307 MEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSRL 366
++ + ++ + + E+ EL + ++ + ++ A+ E L + L S L
Sbjct: 1670 LKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTS---L 1726
Query: 367 PEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQVA 426
++LE ++ QL+ SE E +Q+ + + + D + +
Sbjct: 1727 INTKKKLENDVSQLQ--------------SEVEEVIQESRNAEEKAKKAITDAAMMAEEL 1772
Query: 427 SARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQLVLYGDV 486
Q S L + EQ + LQ RL+ EA+Q L G+ Q +
Sbjct: 1773 KKEQDTSAH-LERMKKNLEQTVKDLQHRLD-----EAEQLALKG-----GKKQ------I 1815
Query: 487 EELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLSSLDNLKASVSQV 546
++L+ V EL VE+ QK + L + + + L Q DR + L L+ V ++
Sbjct: 1816 QKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVL-RLQDLVDKL 1874
Query: 547 EADLKMLRTAVDSLVAYS----VKIETNENNLESAKGLLDDLRNDLDRLFVKVEKIHEKV 602
+A +K + + S K ++ LE A+ D + +++L VK ++H K+
Sbjct: 1875 QAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKI 1934
Score = 63.2 bits (152), Expect = 7e-10
Identities = 88/440 (20%), Positives = 183/440 (41%), Gaps = 71/440 (16%)
Query: 194 ESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDNIA 253
E E++ + E QK ++E+ K +A+ ++ +EE++ L K ND
Sbjct: 849 EKEMATMKEEFQKTKDELAKS---------EAKRKE-------LEEKMVTLLKEKND--- 889
Query: 254 IFTEVQKRSQKEINDMKAKVASLEESEGNKQDLKALKEAVKEIQTSAKSREWDMEALRST 313
+Q + Q E + + E+ NK L+A + V E + ++ A +
Sbjct: 890 ----LQLQVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRK 945
Query: 314 LQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSRLPEEIRRL 373
L+ S++ ++ +L + + K A + + ++ LTE++ +E++++L +E + L
Sbjct: 946 LEDECSELKKDIDDLELTLAKVEKEKHATENK---VKNLTEEMAGLDETIAKLSKEKKAL 1002
Query: 374 EEELRQLKSDSHGPKE-------------------DGGFRHSEAFEA-LQQKSQGLDSRL 413
+E +Q D ++ +G + L++ + L+ L
Sbjct: 1003 QETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDL 1062
Query: 414 QHVEDGVLSMQVASARQTESLE-------SLLSKSQEH-------EQRLAALQGRLEGLG 459
+ ++ + M+ + E LE +L+SK ++ ++++ LQ R+E LG
Sbjct: 1063 KLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELG 1122
Query: 460 SS-EADQDGLASTVRSLGETQLVLYGDVEELKRSVGELPSTVE-------SLQKVQEQVH 511
EA++ A + + L E L+ + G + VE QK++ +
Sbjct: 1123 EEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLE 1182
Query: 512 TLLSQDQAQAARLPPQ--DFLDRL-SSLDNLKASVSQVEADLKMLRTAVDSLVAYSVKIE 568
Q +A A L + D + L +DNL+ ++E + L+ D L + + I
Sbjct: 1183 EATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAIS 1242
Query: 569 TNENNLESAKGLLDDLRNDL 588
+ NLE L+D ++L
Sbjct: 1243 KAKGNLEKMCRSLEDQVSEL 1262
Score = 33.1 bits (74), Expect = 0.75
Identities = 61/288 (21%), Positives = 113/288 (39%), Gaps = 26/288 (9%)
Query: 311 RSTLQTMESDIYTEVRE-LVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSRLPEE 369
R L +E + RE L ++ +AF + L + LL+S E+ +E
Sbjct: 796 RGFLMRVEYQKMLQRREALFCIQYNVRAFMNVKHWPWMKLFFKIKPLLKSAET----EKE 851
Query: 370 IRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQVASAR 429
+ ++EE ++ K D E E L ++ L ++Q D + +
Sbjct: 852 MATMKEEFQKTK-DELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAE----- 905
Query: 430 QTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQLVLYGDVEEL 489
E E L+ + E ++ + R E A+ L + R L + + EL
Sbjct: 906 --ERCEQLIKNKIQLEAKIKEVTERAEEEEEINAE---LTAKKRKLED-------ECSEL 953
Query: 490 KRSVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLSSLDN-LKASVSQVEA 548
K+ + +L T+ ++K + + + A L + + +LS L+ + Q
Sbjct: 954 KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGL--DETIAKLSKEKKALQETHQQTLD 1011
Query: 549 DLKMLRTAVDSLVAYSVKIETNENNLESAKGLLDDLRNDLDRLFVKVE 596
DL+ V+ L K+E ++LE + LR DL+R K+E
Sbjct: 1012 DLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLE 1059
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 71.2 bits (173), Expect = 2e-12
Identities = 115/511 (22%), Positives = 218/511 (42%), Gaps = 101/511 (19%)
Query: 135 QQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVKQGE 194
+QV + Q+ +QRE + L+ +E+K +S E+ L+ Q +LT A +Q +
Sbjct: 937 KQVSKLEQELQKQRESSAEKLRKMEEKCES-----AAHEADLK-RQKVIELTGTA-RQVK 989
Query: 195 SEVSRISEVLQKLQNEILKDLSDG---------IHVVKDARERDFTSLENTVEE------ 239
E+ + E L K++ EI+ DG + ++ D + + N V+E
Sbjct: 990 IEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQH 1049
Query: 240 -RLTELTKSINDNIAIFTEVQK---------RSQKEINDMKAKV-ASLEES--------- 279
TELT+++ + TE+Q R +E+ D+ K SLEE
Sbjct: 1050 STETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTA 1109
Query: 280 ---------EGNKQDLKALKEAVKEIQTSAKSREWDMEALRSTLQTMESDIYTEVREL-- 328
E KQ+L + +A+KE K R + L T++ ++ ++ +L
Sbjct: 1110 ELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEG 1169
Query: 329 ------VSLKQEQQAFKEAADTERLALQALTEK---LLRSEESVSRLPEEIRRLEEELRQ 379
+ LK+ + + D + A + L EK +L++E+ +S+L +EI R ++ +++
Sbjct: 1170 TLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKE 1229
Query: 380 LKSDSHGPKEDGGFRHSEAFEALQQ----KSQGLDSRLQHVEDGVLSMQVASARQTESLE 435
++S ++ ++ EA + Q+ + Q +S + E QV + R+ E L
Sbjct: 1230 MESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAE--ARHQQVQAQREIERLS 1287
Query: 436 SLLSKSQEHEQRLAALQGRL-EGLGSSEADQDGLASTVRSLGETQLVLYGDVEELKRSVG 494
S L ++ + A L E LG+S+ + L + +++ E+K+
Sbjct: 1288 SELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQA-------------EIKK--- 1331
Query: 495 ELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLSSLDNLKASVSQVEADLKM-- 552
L + VESL +E H + Q A+ S D+ K+SV Q+ L+
Sbjct: 1332 -LSAEVESL---KEAYHMEMISHQENHAKWK--------ISADSQKSSVQQLNEQLEKAK 1379
Query: 553 --LRTAVDSLVAYSVKIETNENNLESAKGLL 581
L A D++ +++ +E+A L
Sbjct: 1380 LELEEAQDTVSNLHQQVQDRNEVIEAANEAL 1410
Score = 64.7 bits (156), Expect = 2e-10
Identities = 96/498 (19%), Positives = 219/498 (43%), Gaps = 69/498 (13%)
Query: 141 HQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVKQGESEVSRI 200
H++ +Q E L L+ +Q+ + + T + + QH + ++ + + + E+ +
Sbjct: 763 HKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKE 822
Query: 201 S----EVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDNIAIFT 256
+ E L+ LQN++ ++ +K R+ D ++LE EE + L + + N F
Sbjct: 823 NMKKDEALKALQNQVSEE------TIK-VRQLD-SALEICKEELVLHLNQ-LEGNKEKFE 873
Query: 257 EVQKRSQKEI----NDMKAKVASLEESEGNKQDLKALKEAVKEIQTSAKSREWDMEALRS 312
+ K+ +E+ ++K K SL+E+ L+ + +++ R ++E ++
Sbjct: 874 KQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQT 933
Query: 313 TLQTMESDIYTEVRE--------LVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVS 364
L+ S + E+++ L ++++ ++ AD +R + LT + + +
Sbjct: 934 KLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMD 993
Query: 365 RLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQ 424
+ EE+ ++E+E+ LK D E+ S+ L Q L+ + V++ +
Sbjct: 994 QYKEELSKMEKEIMHLKRDG----ENKAMHLSQLDMILDQTKTELEKKTNAVKE---LEK 1046
Query: 425 VASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQLVLYG 484
+ + +TE E+ L K + E L G L+ ST+R L E + VL
Sbjct: 1047 LQHSTETELTEA-LQKREVLETELQNAHGELK-------------STLRQLQELRDVLQK 1092
Query: 485 ---DVEELKRSVGELPSTV-ESLQKVQEQVHTLLSQDQA----------QAARLPPQDFL 530
+EE ++ +L + + E +++++ LL DQA +AA++ D
Sbjct: 1093 AQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMT 1152
Query: 531 DR------LSSLDNLKASVSQVEADLKMLRTAVDSLVAYSVKIETNENNLESAKGLLDDL 584
R + L+ ++ + E +LK ++SL + K++ + L + ++
Sbjct: 1153 IREHRGEMEQKIIKLEGTLEKSELELKECNKQIESL---NDKLQNAKEQLREKEFIMLQN 1209
Query: 585 RNDLDRLFVKVEKIHEKV 602
++ +L ++E+ +++
Sbjct: 1210 EQEISQLKKEIERTQQRM 1227
Score = 55.1 bits (131), Expect = 2e-07
Identities = 95/488 (19%), Positives = 194/488 (39%), Gaps = 39/488 (7%)
Query: 128 HHVLEEV--QQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDL 185
H V E V Q ++ + ++R+ L G++ + K+ ++A + + + L
Sbjct: 614 HQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQL 673
Query: 186 TEKAVKQGESEVSRISEVLQKLQNEIL---KDLSDGIHVVKDARERDFTSLENTVEERLT 242
++ + + S S++ + K +++L K L + I ++ LE + E+
Sbjct: 674 IQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKN-AELEQELMEK-N 731
Query: 243 ELTKSINDNIAIFTEVQKRSQKEINDMKAKVASLEESEGNKQDLKALKEAVKEIQTSAKS 302
E +S+ NI TE +K + KAK LE+ K +++ ++ ++ +
Sbjct: 732 EKIRSLETNIN--TEHEKIC---LAFEKAKKIHLEQH-------KEMEKQIERLEAQLEK 779
Query: 303 REWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERL----ALQALTEKLLR 358
++ + T+ ++ DI + L SL + K E + AL+AL ++
Sbjct: 780 KDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSE 839
Query: 359 SEESVSRLPEEIRRLEEELRQLKSDSHGPKEDGG---FRHSEAFEALQQKSQGLDSRLQH 415
V +L + +EEL + G KE + SE LQ++ + + LQ
Sbjct: 840 ETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQE 899
Query: 416 VEDGVLSMQVASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSS-EADQDGLASTVRS 474
+ + +Q +Q + L+ ++ E E L+ ++ L + ++ A +R
Sbjct: 900 TSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRK 959
Query: 475 LGETQLVLYGDVEELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLS 534
+ E + + ++ V EL T ++ +Q LS+ + + L +D ++
Sbjct: 960 MEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHL-KRDGENKAM 1018
Query: 535 SLDNLKASVSQVEADLKMLRTAVDSLVAYSVKIETN-----------ENNLESAKGLLDD 583
L L + Q + +L+ AV L ET E L++A G L
Sbjct: 1019 HLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKS 1078
Query: 584 LRNDLDRL 591
L L
Sbjct: 1079 TLRQLQEL 1086
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 70.9 bits (172), Expect = 3e-12
Identities = 119/517 (23%), Positives = 222/517 (42%), Gaps = 93/517 (17%)
Query: 130 VLEEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSL--QATFGTFESILRSSQHKQDLTE 187
+LE + Q ++ D S+Q E L Q + KVQ L Q T G ++ L+ +Q + +
Sbjct: 930 LLETLLQTQKELADASQQLERLRQ-----DMKVQKLKEQETTGILQTQLQEAQRE---LK 981
Query: 188 KAVKQGESEVSRISEVLQKLQNEILKDLSDGIHVVKD------ARERDFTSLENTVEERL 241
+A +Q +++ LQ+ + +L+D D V+D A++ +E V+E+L
Sbjct: 982 EAARQHRDDLA----ALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKL 1037
Query: 242 TELTKSINDNIAIFTEVQKRSQKE-------INDMKAKVASLEESEG-NKQDLKALKEAV 293
E + + +QK ++E + + + ++ L+E++ +Q+L AL++ +
Sbjct: 1038 RETQE--------YNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDM 1089
Query: 294 KEIQTSAKSREWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALT 353
+E Q K ME LR ++ E+D L QE Q +E + + Q L
Sbjct: 1090 QEAQGEQKELSAQMELLRQEVKEKEADF---------LAQEAQLLEE-LEASHITEQQLR 1139
Query: 354 EKLLRSEESVSRLPEEIRRLEEELRQLKSDSH-GPKEDGGFRHSEAFEALQQK------- 405
L E ++L +R E +L L ++ G + + + + ALQQ
Sbjct: 1140 ASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCES 1199
Query: 406 ----SQGLDSR-----LQHVEDGVLSM----QVASARQTESLESLLSKSQEH----EQRL 448
S G DS L+ ++G S+ + +A E++ S L K + +Q
Sbjct: 1200 RPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTR 1259
Query: 449 AALQGRLEGLGSSEADQDGLASTVRS-LGETQLVLYGDVEELKRSVGELPSTVESLQKVQ 507
L+ +++ L D + S V + L + Q L + EE + G+ S L ++
Sbjct: 1260 DVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELH 1319
Query: 508 EQVHTLLSQ-DQAQAARLPPQDFLDRL-SSLDNLKASVSQVEADLKMLRTAVDSLVAYSV 565
E + +L S+ +A+ R+ Q + L ++ +NL A V ++A + R
Sbjct: 1320 ETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQA-------- 1371
Query: 566 KIETNENNLESAKGLL-DDLRNDLDRLFVKVEKIHEK 601
SA G+L +DLR L +K E++ +
Sbjct: 1372 ----------SAAGILEEDLRTARSALKLKNEEVESE 1398
Score = 68.9 bits (167), Expect = 1e-11
Identities = 94/435 (21%), Positives = 183/435 (42%), Gaps = 29/435 (6%)
Query: 132 EEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQH-KQDLTEKAV 190
+E+Q D L + LQ +Q+V+S + E + R +H QDL +
Sbjct: 1602 QELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQI---EELQRQKEHLTQDLERRDQ 1658
Query: 191 K-QGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTE---LTK 246
+ + E ++ E + Q +IL++ + I + R R+ T+ ++ER E +K
Sbjct: 1659 ELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSK 1718
Query: 247 SINDNIAIFTEVQKRSQKEINDMKAKVASLEESEGN-KQDLKALKEAVKEIQTSAKSREW 305
+ ++ + + +KE+ + + L+E + +Q L+ L V E RE
Sbjct: 1719 AQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQ 1778
Query: 306 DMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSR 365
++ L+ LQ + + L S E Q D E ALQ ++ EE V
Sbjct: 1779 EIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKE 1838
Query: 366 LPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQV 425
+ ++ E+ + HG +D H E L+++ R+Q +E+ + ++
Sbjct: 1839 KADALQGALEQAHMTLKERHGELQD----HKEQARRLEEELAVEGRRVQALEEVLGDLRA 1894
Query: 426 ASARQTESLESL----LSKSQEHEQRLAALQGR-LEG---LGSSEADQDGLASTVRSLGE 477
S Q ++L +L ++QEHE ALQ L+ L + + + L + +S
Sbjct: 1895 ESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRH 1954
Query: 478 TQLVLYGDVEELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLSSLD 537
+ E L+ ++G+ + ++ ++ H L +QA+ +R +SLD
Sbjct: 1955 QEEAARARAEALQEALGKAHAALQG-----KEQHLL---EQAELSRSLEASTATLQASLD 2006
Query: 538 NLKASVSQVEADLKM 552
+A Q+E L++
Sbjct: 2007 ACQAHSRQLEEALRI 2021
Score = 64.7 bits (156), Expect = 2e-10
Identities = 104/513 (20%), Positives = 211/513 (41%), Gaps = 69/513 (13%)
Query: 127 VHHVLEEVQQVRRSHQDFSRQREELGQGLQGVEQKV----QSLQATFGTFESILRSSQHK 182
+H + E Q+ + Q R+ E L EQ++ Q LQ E +S Q +
Sbjct: 1745 IHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQ 1804
Query: 183 QDLTEKAVKQGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLT 242
D ++A+ Q + E+ + + Q+ Q + + + DA + T++ER
Sbjct: 1805 LDEAQRALAQRDQELEALQQEQQQAQGQ-----EERVKEKADALQGALEQAHMTLKERHG 1859
Query: 243 EL------TKSINDNIAIFTEVQKRSQKEINDMKAKVAS------------LEESEGNKQ 284
EL + + + +A+ + ++ + D++A+ E+++ ++
Sbjct: 1860 ELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEV 1919
Query: 285 DLKALKEAVKEIQTSAKSREWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADT 344
+ +AL+++ + Q K R+ ++EALR+ Q+ + + + +A +EA
Sbjct: 1920 ETRALQDSWLQAQAVLKERDQELEALRAESQSSR-------HQEEAARARAEALQEALGK 1972
Query: 345 ERLALQALTEKLLRSEE--------------SVSRLPEEIRRLEEELRQLKSDSHGPKED 390
ALQ + LL E S+ R+LEE LR G +D
Sbjct: 1973 AHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRI----QEGEIQD 2028
Query: 391 GGFRHSEAFEALQQKSQGLDSRLQHVE--DGVLSMQVASARQTESLESLLSKSQEHEQRL 448
R+ E + LQQ D L+H + + +L +A Q ++ + QE E+
Sbjct: 2029 QDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEE- 2087
Query: 449 AALQGRLEGLGSSEADQDGLASTVRSLGETQLVLYGDVEELKRSVGELPSTVESLQ--KV 506
++G + + + + L ETQ ++E L S P +SL+ +
Sbjct: 2088 -EIRGLHQSVRELQLTLAQKEQEILELRETQ--QRNNLEALPHSHKTSPMEEQSLKLDSL 2144
Query: 507 QEQVHTLLSQDQAQAARLPPQDFLDRLSSLDNLKASVSQVEADLKMLRTAVDSLVAYSVK 566
+ ++ L + QA + ++ R + D L S++Q +A + L+ L A ++
Sbjct: 2145 EPRLQRELERLQAALRQTEAREIEWREKAQD-LALSLAQTKASVSSLQEVAMFLQASVLE 2203
Query: 567 IETNENNLESAKGLLDDLRNDLDRLFVKVEKIH 599
++ + L+ D+L +L R ++ E++H
Sbjct: 2204 RDSEQQRLQ------DEL--ELTRRALEKERLH 2228
Score = 60.1 bits (144), Expect = 6e-09
Identities = 107/493 (21%), Positives = 193/493 (39%), Gaps = 85/493 (17%)
Query: 146 RQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEK-------AVKQGESEVS 198
R+RE L + L G+E K + T L SS + +L + A+ + E ++
Sbjct: 519 RERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIA 578
Query: 199 RISEVLQKLQNEI---------LKDLSDGIHVVKDARERDFTSLEN---TVEERLTELTK 246
+S L+ E+ L L++ + + K + LE +V R+ +
Sbjct: 579 ELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQ 638
Query: 247 SINDNIAIFTEVQKRSQ---KEINDMKAKVASLEESEGNKQ-DLKALKEAVKEIQTSAKS 302
+ N E +KR + ++ ++A++ EE+ Q DL+ ++E +EIQ
Sbjct: 639 ARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSE 698
Query: 303 REWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEES 362
EA + L+ + + + L QE KEA E+ AL+ + + R +
Sbjct: 699 SRHQQEAATTQLEQLHQEAKRQEEVLARAVQE----KEALVREKAALEVRLQAVERDRQD 754
Query: 363 VSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLS 422
L E+L+ L S S FEA QQ S + V G L
Sbjct: 755 ----------LAEQLQGLSSAKE-------LLESSLFEAQQQNS------VIEVTKGQLE 791
Query: 423 MQVASARQTE----------SLESLLSKSQEHEQRLAA----LQGRLEGLGSSEADQDGL 468
+Q+ + Q + LE +SQ ++R AA Q EG + E +
Sbjct: 792 VQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAH 851
Query: 469 ASTVRSLGETQLVLYGDVEELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQD 528
V L E +E EL +ESL++ + ++ L + Q + + Q
Sbjct: 852 EKEVNQLREKW------EKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQR 905
Query: 529 FLDRLSSLDNLKASVSQVEADLKMLRTAVDSLVAYSVKIETNENNLESAKGLLDDLRNDL 588
+R + ++++ Q++ L T + + ++T + L A L+ LR D+
Sbjct: 906 EEERTQA----ESALCQMQ-----LETEKERVSLLETLLQT-QKELADASQQLERLRQDM 955
Query: 589 DRLFVKVEKIHEK 601
KV+K+ E+
Sbjct: 956 -----KVQKLKEQ 963
Score = 55.8 bits (133), Expect = 1e-07
Identities = 100/492 (20%), Positives = 205/492 (41%), Gaps = 52/492 (10%)
Query: 130 VLEEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKA 189
+L + Q++ + + S++ +L QG +K + LQ ++L SQ + + EK
Sbjct: 249 LLAKTQELEKEAHERSQELIQLKS--QGDLEKAE-LQDRVTELSALLTQSQKQNEDYEKM 305
Query: 190 VKQGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSIN 249
+K V E+L+ E+++ + + ++A+E SL+ +++ +T++
Sbjct: 306 IKALRETV----EILETNHTELMEHEAS---LSRNAQEEKL-SLQQVIKD-ITQVMVEEG 356
Query: 250 DNIA--------------IFTEVQKRSQKEINDMKAKVASLEES--EGNKQDLKALKEAV 293
DNIA IF++ + + + V + + +Q L +EAV
Sbjct: 357 DNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAV 416
Query: 294 KEIQTSAKSREWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALT 353
+Q E + +ALR LQ + + T + V L+ E + + ER LQ
Sbjct: 417 NLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSK----ERELLQKAR 472
Query: 354 EKLLRSEESVSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAF---EALQQKSQGLD 410
E+L + E + + +RR+ EL+ + G KE+ A E LQ+ GL+
Sbjct: 473 EELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLE 532
Query: 411 SRLQHVEDGVLSMQVASARQTESLESLLSKSQE---------HEQRLAALQGRLEGLGSS 461
++ +++++ A ++ LE L + ++ EQ +A L L +
Sbjct: 533 AKQSESLSELITLR--EALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTE 590
Query: 462 EADQDGLASTVRSLGETQLVLYGDVEELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQA 521
AD A + +L E + + + + E +V S + EQ L D A+A
Sbjct: 591 VADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEA 650
Query: 522 ARLPP---QDFLDRLSSLDNLKASVSQVEADLKMLRTAVDSLVAYSVKIETNENNLESAK 578
+ + + L + + ++++ADL+ ++ + + K+ + + E+A
Sbjct: 651 EKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEI---QKKLSESRHQQEAAT 707
Query: 579 GLLDDLRNDLDR 590
L+ L + R
Sbjct: 708 TQLEQLHQEAKR 719
Score = 47.8 bits (112), Expect = 3e-05
Identities = 85/501 (16%), Positives = 204/501 (40%), Gaps = 64/501 (12%)
Query: 127 VHHVLEEVQQVRRSHQD----FSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHK 182
VH L+++Q+ +Q+ + ++ L L + + + SLQ+ E +Q +
Sbjct: 1283 VHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGE 1342
Query: 183 QDLTEKAVKQGESEVSRISEVL--QKLQNEILKDLSDGIHVVKDARERDFTSLENTVE-- 238
++L + A + ++V + + + Q L + + + A + +E+ E
Sbjct: 1343 RELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERA 1402
Query: 239 -------ERLTELTKSINDNIAIFTEVQKRSQKEINDMKAKVASLEESEGNK-------- 283
E K++ +N+A+ T+ ++E+ ++ ++ LE+ +
Sbjct: 1403 QALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLS 1462
Query: 284 -----------------QDLKALKEAVKEIQTSAKSREWDMEALRSTLQTMESDIYTEVR 326
Q+L+ + ++ + + + RE + R ++ +E D T+
Sbjct: 1463 LDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRN 1522
Query: 327 ELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSRLPEEIRRLEEELRQLKSDSHG 386
L E + + +++R +Q L ++L+ E L E ++E + + +K + G
Sbjct: 1523 VLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIK-ELEG 1581
Query: 387 PKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQVASARQTESLESLLSKSQEHEQ 446
+E + L+++SQ L ++ + D + S AR+ + + + +E
Sbjct: 1582 QRETQRVALTHLTLDLEERSQELQAQSSQIHD-LESHSTVLARELQERDQEVKSQRE--- 1637
Query: 447 RLAALQGRLEGLGS--SEADQDGLASTVR-SLGETQ-----LVLYGDVEELKRSVGELPS 498
++ LQ + E L DQ+ + R + E Q +L D+E++K S+ E
Sbjct: 1638 QIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGR 1697
Query: 499 TVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLSSLDNLKASVSQVEADLKMLRTAVD 558
+ + ++ L Q++A+ + P + + SL+++K + E +++ + +
Sbjct: 1698 ELTTQRQ--------LMQERAEEGKGPSK---AQRGSLEHMKLILRDKEKEVECQQEHIH 1746
Query: 559 SLVAYSVKIETNENNLESAKG 579
L ++E L G
Sbjct: 1747 ELQELKDQLEQQLQGLHRKVG 1767
Score = 42.4 bits (98), Expect = 0.001
Identities = 63/314 (20%), Positives = 121/314 (38%), Gaps = 49/314 (15%)
Query: 142 QDFSRQREELGQGLQG--------VEQKVQSLQATFGTFESILRSSQHKQDLTEKAVKQG 193
Q SRQ EE + +G ++ VQ LQ + LR Q ++ L EK++ Q
Sbjct: 2009 QAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQR 2068
Query: 194 --ESEVSRISEVLQKLQNEILKDLSDGIHVVK---DARERDFTSLENTVEERLTEL---- 244
E+ + + Q+ + E ++ L + ++ +E++ L T + E
Sbjct: 2069 VQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHS 2128
Query: 245 --TKSINDNIAIFTEVQKRSQKEINDMKAKVASLEESE---------------GNKQDLK 287
T + + ++ R Q+E+ ++A + E E K +
Sbjct: 2129 HKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVS 2188
Query: 288 ALKEAVKEIQTSAKSREWDMEALRSTLQT---------MESDIYTEVRELVSLKQEQQAF 338
+L+E +Q S R+ + + L+ L+ + S T EL S ++
Sbjct: 2189 SLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQL 2248
Query: 339 KEAADTER------LALQALTEKLLRSEESVSRLPEEIRRLEEELRQLKSDSHGPKEDGG 392
E + E + Q+ ++L +++V+RL + RL+ QL+S + +
Sbjct: 2249 GEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERR 2308
Query: 393 FRHSEAFEALQQKS 406
EA A Q S
Sbjct: 2309 KLKREAMRAAQAGS 2322
Score = 31.6 bits (70), Expect = 2.2
Identities = 55/262 (20%), Positives = 109/262 (41%), Gaps = 42/262 (16%)
Query: 158 VEQKVQSLQATFGTFESILRSSQHKQDLTEKAVKQGESEVSRISEVLQKLQNEILKDLSD 217
++++++ LQA E+ + K ++ Q ++ VS + EV LQ +L+
Sbjct: 2148 LQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLE---- 2203
Query: 218 GIHVVKDARERDFTSLENTVEERLTELTKSINDNIAIFTEVQKRSQKEINDMKAKVASLE 277
R+ + L++ +E L K + + + S+ E +V+ +E
Sbjct: 2204 --------RDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVE 2255
Query: 278 --------ESEGNKQDLKALKEAVKEIQTSAKSREWDMEALRSTLQTMESDIYTEVRELV 329
E + +Q L+ L++AV ++ + LRSTL+ +E RE
Sbjct: 2256 AEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVE-------RERR 2308
Query: 330 SLKQEQQAFKEAADTE--RLALQALTEKLLRSEES-----VSRLPEEIRRLEEEL---RQ 379
LK+E +A E + + T++ R +++ V+ L +E+ L+ +L R+
Sbjct: 2309 KLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERK 2368
Query: 380 LKSD-----SHGPKEDGGFRHS 396
K D + +E G HS
Sbjct: 2369 QKQDYITRSAQTSRELAGLHHS 2390
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 70.9 bits (172), Expect = 3e-12
Identities = 114/490 (23%), Positives = 200/490 (40%), Gaps = 54/490 (11%)
Query: 134 VQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVKQG 193
V Q +R + SR+ EEL ++ Q+ QA E LRS Q K
Sbjct: 638 VTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQK----------- 686
Query: 194 ESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDNIA 253
+E R+++ +LQ E L+ L + + V K + E + + +EE+ +
Sbjct: 687 ATEKERVAQEKDQLQ-EQLQALKESLKVTKGSLEEEKRRAADALEEQ-QRCISELKAETR 744
Query: 254 IFTEVQKRSQKEINDMKAKVASLEE-----SEGNKQDLKALKEAVKEIQTSAKSREWDME 308
E KR +KE+ + +A LE E ++ + + L+ + E + + E + E
Sbjct: 745 SLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECE 804
Query: 309 ALRSTLQTME---SDIYTEVRELVSLKQEQ-QAFKEAADTERLALQALTEKLLRSEESVS 364
L + D E + ++ QEQ KE + R LQ EK + ES S
Sbjct: 805 QLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEK-VAGIESHS 863
Query: 365 RLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQ 424
L +I R + EL +L H+ ALQQ Q + R Q + D + ++Q
Sbjct: 864 EL--QISRQQNELAEL--------------HANLARALQQ-VQEKEVRAQKLADDLSTLQ 906
Query: 425 ---VASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTV-RSLGETQL 480
A++++ LE+L+ K+ E +Q A+ + E + + + L R TQ
Sbjct: 907 EKMAATSKEVARLETLVRKAGE-QQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQA 965
Query: 481 VLYGDVEELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLSSLDNLK 540
L E ++ EL +L + Q Q Q + + ARL Q+ + L K
Sbjct: 966 ALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARL-TQERGRAQADLALEK 1024
Query: 541 ASVSQVEADLK--------MLRTAVDSLVAYSVKIETNENNLESAKGLLDDLRNDLDRLF 592
A+ +++E L+ T ++L + E + L +GL +L+ L
Sbjct: 1025 AARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELR 1084
Query: 593 VKVEKIHEKV 602
V+++ E++
Sbjct: 1085 QTVKQLKEQL 1094
Score = 62.4 bits (150), Expect = 1e-09
Identities = 86/328 (26%), Positives = 147/328 (44%), Gaps = 35/328 (10%)
Query: 228 RDFTSLENTVEERLTELTKSINDNIAIFTEVQKRSQKEINDMKAKVASLEESEGNKQDLK 287
R+F S +++ L ELT+ + + E Q + +KE++ A+L QD K
Sbjct: 328 REFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELS------AAL-------QDKK 374
Query: 288 ALKEAVKEIQTSAKSREWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERL 347
L+E + +Q E + L+ + ++ +V +L +LKQE A A +T+
Sbjct: 375 CLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQE-AATLAANNTQ-- 431
Query: 348 ALQALTEKL-LRSEESVSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKS 406
LQA E L + ++L E EEE +QL S + S+A E L+Q S
Sbjct: 432 -LQARVEMLETERGQQEAKLLAERGHFEEEKQQL-SSLITDLQSSISNLSQAKEELEQAS 489
Query: 407 QGLDSRLQHVEDGVLSMQVASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQD 466
Q +R L+ QVAS T L +L + Q+ +Q LA L+ + ++ Q
Sbjct: 490 QAHGAR--------LTAQVASL--TSELTTLNATIQQQDQELAGLKQQ------AKEKQA 533
Query: 467 GLASTVRSLGETQLVLYGDVEELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPP 526
LA T++ + L VE+L S+ + ++ + + QE +Q A AA
Sbjct: 534 QLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEERE 593
Query: 527 QDFLDRLSSLDNLKASVSQVEADLKMLR 554
+R ++L L+A + A L++L+
Sbjct: 594 ASLRERDAALKQLEALEKEKAAKLEILQ 621
Score = 62.4 bits (150), Expect = 1e-09
Identities = 112/479 (23%), Positives = 212/479 (44%), Gaps = 66/479 (13%)
Query: 129 HVLEEVQQV-------RRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQH 181
H EE QQ+ + S + S+ +EEL Q Q ++ + A+ + + L ++
Sbjct: 456 HFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQ 515
Query: 182 KQDLTEKAVK-QGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEER 240
+QD +K Q + + +++++ LQ+ Q + + L + + + ++ L+ E++
Sbjct: 516 QQDQELAGLKQQAKEKQAQLAQTLQQ-QEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQ 574
Query: 241 LTELTKSIN-DNIAIFTEVQKRSQKEINDMKAKVASLEESEGNK-----QDLKALKEAVK 294
E T+ + +A E ++ S +E + ++ +LE+ + K Q L+ EA
Sbjct: 575 --EATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARD 632
Query: 295 EIQTSAKSREWDMEALRSTLQTMESDIYT----------EVREL-VSLKQEQQAFKEAAD 343
QTS + + L ++ +++ + T +V EL + L+ EQQ +A +
Sbjct: 633 SAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQ---KATE 689
Query: 344 TERLA---------LQALTEKLLRSEESVSRLPEEIRR----LEEELR---QLKSDSHGP 387
ER+A LQAL E L ++ S L EE RR LEE+ R +LK+++
Sbjct: 690 KERVAQEKDQLQEQLQALKESLKVTKGS---LEEEKRRAADALEEQQRCISELKAETRSL 746
Query: 388 KEDGGFRHSEAFEALQQKSQGLDSRLQHV------EDGVLSMQVASARQTESLESLLSKS 441
E R + E + +GL++RLQ + E VL ++A A + + S+
Sbjct: 747 VEQHK-RERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQ--HTAESEC 803
Query: 442 QEHEQRLAALQGRLEGLGSSEADQDGL-ASTVRSLGETQLVLYGDVEELKRSVGELPS-- 498
++ + +AA + R E EA + + +L E +++E K V + S
Sbjct: 804 EQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHS 863
Query: 499 --TVESLQKVQEQVHTLLSQ--DQAQAARLPPQDFLDRLSSLDNLKASVSQVEADLKML 553
+ Q ++H L++ Q Q + Q D LS+L A+ S+ A L+ L
Sbjct: 864 ELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETL 922
Score = 60.1 bits (144), Expect = 6e-09
Identities = 92/480 (19%), Positives = 190/480 (39%), Gaps = 74/480 (15%)
Query: 135 QQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLT-------- 186
QQ + ++ ++ Q QG+ +V+ L ++ E L+ KQ+ T
Sbjct: 526 QQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQL 585
Query: 187 -------EKAVKQGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEE 239
E ++++ ++ + ++ E L+K + L+ L + V +AR+ TS+ E
Sbjct: 586 ATAAEEREASLRERDAALKQL-EALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQRE 644
Query: 240 RLTELTKSINDNIAIF----------------TEVQKRSQKEINDMKAKVASLEESEGNK 283
+ EL++ + + A E+Q RS+++ K +VA +E + +
Sbjct: 645 K-AELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVA--QEKDQLQ 701
Query: 284 QDLKALKEAVKEIQTSAKSREWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAAD 343
+ L+ALKE++K + S + + Q S++ E R LV + ++ E
Sbjct: 702 EQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEER 761
Query: 344 TERLALQALTEKLLRSEESVSRL---------------PEEIRRLEEEL---RQLKSDSH 385
R L+A ++L + ++ + + E +L +E+ R+ DS
Sbjct: 762 AGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQ 821
Query: 386 GPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQVASARQTESLESLLSKSQEHE 445
+ G E L+++ + LQ ++ V ++ S Q ++ L++
Sbjct: 822 QEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELH--- 878
Query: 446 QRLAALQGRLEGLGSSEADQDGLASTVRSLGETQLVLYGDVEELKRSVGELPSTVESLQK 505
A L L+ + E LA + +L E + + V L + V +
Sbjct: 879 ---ANLARALQQVQEKEVRAQKLADDLSTLQE-------KMAATSKEVARLETLVRKAGE 928
Query: 506 VQEQVHTLLSQDQAQAARLPPQ--------DFLDRLSSLDNLKASVSQVEADLKMLRTAV 557
QE L ++ A+A P+ F ++L ++ Q+ +L+ LR A+
Sbjct: 929 QQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAAL 988
Score = 56.2 bits (134), Expect = 8e-08
Identities = 106/520 (20%), Positives = 210/520 (40%), Gaps = 63/520 (12%)
Query: 126 CVHHVLEEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSL----QATFGTFESILRSSQH 181
C+ + E + + H+ ++ EE G +G+E ++Q L QA L +
Sbjct: 735 CISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMA 794
Query: 182 KQDLTEKAVKQGESEVSRISEVLQKLQNEILK---DLSDGIHVVKDARERDFTSLENTVE 238
Q E +Q EV+ E + Q E + + + +K+ E+ L+ E
Sbjct: 795 AQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKE 854
Query: 239 ERLTELTKSINDNIAIFTEVQ-KRSQKEINDMKAKVA-SLEESEGNKQDLKALKEAVKEI 296
+ I +E+Q R Q E+ ++ A +A +L++ + + + L + + +
Sbjct: 855 KVA---------GIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTL 905
Query: 297 QTSAKSREWDMEALRSTLQTMESDIYTEVRELV-----SLKQEQQAFKEAADTERLALQA 351
Q + ++ L + ++ T RELV + ++ + +E + + QA
Sbjct: 906 QEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQA 965
Query: 352 LTEKLLRSEESVSRLPEEIRRLEEELRQLKSDSHGPKEDGGFR------HSEAFEALQQK 405
+ + R E + E +R E + + + G +E R ++A AL++
Sbjct: 966 ALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKA 1025
Query: 406 SQG-LDSRLQHVEDGVLSMQVASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEAD 464
++ L+ RLQ + + +V A E+L L++ + +Q LA L+G LE E +
Sbjct: 1026 ARAELEMRLQ---NALNEQRVEFATLQEALAHALTEKEGKDQELAKLRG-LEAAQIKELE 1081
Query: 465 QDGLASTVRSLGE--------------TQLVLYGDVE----ELKRSVGELPSTVESLQKV 506
+ L TV+ L E Q G E +L+ E+ + QK
Sbjct: 1082 E--LRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQ 1139
Query: 507 QEQVHTLLSQDQAQAARLPPQDFLDRLSSLDNLKASVSQVEADL----KMLRTAVDSLVA 562
QEQ +L +A+ A +D S+L+ L+ + + +L L +A L A
Sbjct: 1140 QEQADSLERSLEAERASRAERD-----SALETLQGQLEEKAQELGHSQSALASAQRELAA 1194
Query: 563 YSVKIETNENNLESAKGLLDDLRNDLDRLFVKVEKIHEKV 602
+ K++ + + K + R + +R + + E+V
Sbjct: 1195 FRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEV 1234
Score = 54.3 bits (129), Expect = 3e-07
Identities = 74/383 (19%), Positives = 151/383 (39%), Gaps = 45/383 (11%)
Query: 127 VHHVLEEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLT 186
V + E++ + + H S + E + K+++L+A E + Q + D
Sbjct: 1087 VKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSL 1146
Query: 187 EKAVKQGESEVSRISEVLQKLQNEILKDLSDGIHVVKD--ARERDFTSLENTVE------ 238
E++++ + + L+ LQ ++ + + H + +R+ + V+
Sbjct: 1147 ERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAE 1206
Query: 239 --------------ERLTELTKSINDNIAIFTEVQKRSQKEINDMKAKV-ASLEESEGNK 283
ER L S+ + ++I + E ++K V A E+S+ +
Sbjct: 1207 DEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLE 1266
Query: 284 QDLKALKEAVKEIQTSAKSREWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAAD 343
+ L+ L+ A R ALR +Q++ + + +L+QE + E A+
Sbjct: 1267 ERLRLLQAETASNSARAAERS---SALREEVQSLREEAEKQRVASENLRQELTSQAERAE 1323
Query: 344 TERLALQALTEKLLRSEESVSRLPEEIRRLEEELRQLKSDSH------GPKEDGGFRHSE 397
L+A EK + E+++S L E + + +L H + RH E
Sbjct: 1324 ELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHRE 1383
Query: 398 AFEALQQKSQGLDS---RLQHVEDGVLSMQVASARQTESLESLLSKSQEHEQRLAALQGR 454
E +Q + GL + R Q ++ ++ A Q + + L ++ + ++L+ L+ +
Sbjct: 1384 ELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLK-K 1442
Query: 455 LEGLGSSEADQDGLASTVRSLGE 477
GL LA R LGE
Sbjct: 1443 AHGL---------LAEENRGLGE 1456
Score = 53.9 bits (128), Expect = 4e-07
Identities = 71/327 (21%), Positives = 134/327 (40%), Gaps = 48/327 (14%)
Query: 225 ARERDFTSLENTVEERLTELTKSINDNIAIFTEVQKRSQKEINDMKAKVASLEES----- 279
A F + + +T+L SI++ E+++ SQ + A+VASL
Sbjct: 452 AERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLN 511
Query: 280 ---EGNKQDLKALKEAVKEIQT----SAKSREWDMEALRSTLQTMESDIYTEVRELVSLK 332
+ Q+L LK+ KE Q + + +E + LR ++ + S SLK
Sbjct: 512 ATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSS----------SLK 561
Query: 333 QEQQAFKEAADTERLALQALTEKLLRSEESVSRLPEEIRRLEEELRQLKSDSHGPKEDGG 392
Q++Q KE A+ + Q ++L + E +R + L+QL++
Sbjct: 562 QKEQQLKEVAEKQEATRQDHAQQLATAAE---EREASLRERDAALKQLEALEK------- 611
Query: 393 FRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQVASARQTESLESL-----LSKSQEHEQR 447
+ E LQQ+ Q + + V Q A + +E L ++ ++HE +
Sbjct: 612 -EKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQ 670
Query: 448 LAA----LQGRLEGLGSSE-----ADQDGLASTVRSLGETQLVLYGDVEELKRSVGE-LP 497
LQ R E ++E ++D L +++L E+ V G +EE KR + L
Sbjct: 671 AQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALE 730
Query: 498 STVESLQKVQEQVHTLLSQDQAQAARL 524
+ +++ + +L+ Q + + L
Sbjct: 731 EQQRCISELKAETRSLVEQHKRERKEL 757
Score = 47.8 bits (112), Expect = 3e-05
Identities = 83/420 (19%), Positives = 175/420 (41%), Gaps = 23/420 (5%)
Query: 129 HVLEEVQQVRRSHQDFSRQREELGQGLQ---GVEQKVQSLQATFGTFESILRSSQHKQDL 185
H+ +++Q + + + R REEL Q Q G+ ++ Q G LR +Q+
Sbjct: 1365 HLCQQLQAEQAAAE--KRHREELEQSKQAAGGLRAELLRAQRELGELIP-LRQKVAEQER 1421
Query: 186 TEKAVKQGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELT 245
T + ++ ++ + +L+K + ++ R+ L+ E+ + EL
Sbjct: 1422 TAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELA 1481
Query: 246 KSINDNIAIFTEVQKRSQKEINDMK--------AKVASLEESEGNKQDLKALKEAVKEIQ 297
D EVQ+ +Q +++ AKV LEE + +++ + L V++++
Sbjct: 1482 AVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLE 1541
Query: 298 TSAKSREWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLL 357
+ + +E L L +SD ++V++ + Q + + +RL Q L E L
Sbjct: 1542 VFQREQTKQVEELSKKL--ADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQ-LNE--L 1596
Query: 358 RSEESVSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVE 417
+++ S E +L+ E + D+ + + E LQ++++ L + + +
Sbjct: 1597 QAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLG 1656
Query: 418 DGVLSMQVASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGE 477
+ + + ++ L ++ + E ++A +L LG + D L S +
Sbjct: 1657 HELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSR-EPQAK 1715
Query: 478 TQLVLYGDVEELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQ-AARLPPQDFLDRLSSL 536
QL L D +L G S L + Q ++ + + + RLPP+ ++ L SL
Sbjct: 1716 PQLDLSIDSLDLSCEEGTPLSITSKLPRTQPDGTSVPGEPASPISQRLPPK--VESLESL 1773
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 70.5 bits (171), Expect = 4e-12
Identities = 109/490 (22%), Positives = 210/490 (42%), Gaps = 56/490 (11%)
Query: 146 RQREELGQGLQGVEQKVQSLQATFGTFES--------ILRSSQHKQDLTEKAVKQGESEV 197
+Q EE + G QKV SL+A S + + + +DL K VK E E+
Sbjct: 1500 QQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAK-VKDQEEEL 1558
Query: 198 SRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDNIAIFTE 257
+ +Q L+ L+ L + ++ ++ S + VEE K + E
Sbjct: 1559 DEQAGTIQMLEQAKLR-LEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEE 1617
Query: 258 VQKRSQK---EINDMKAKVASLEESEGNKQDLKALKEAVKEIQTSAKSREWDMEALRSTL 314
+ QK E +++ K+A+L + + N++D ++ K K+++ + K+ D + + L
Sbjct: 1618 EYEDKQKVLREKRELEGKLATLSD-QVNRRDFESEKRLRKDLKRT-KALLADAQLMLDHL 1675
Query: 315 QTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSR----LPEEI 370
+ + E+ +L + +E + AA R A++ E L + +++ L E++
Sbjct: 1676 KN-SAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQL 1734
Query: 371 RRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQVASARQ 430
RL+ E ++++ +ED + A+ Q S+ L + +Q
Sbjct: 1735 SRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQ--------INDLQA----- 1781
Query: 431 TESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQLVLYGD---VE 487
LE + QE +++L ALQ ++E L S D+ ++ + E + L + V+
Sbjct: 1782 --QLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVK 1839
Query: 488 ELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQ--DFLDRLSSLDNLKASVS- 544
L+ L +E L + ++Q ++++ Q RL Q D + + L +A S
Sbjct: 1840 RLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASR 1899
Query: 545 ---QVEADLKMLRTAVDSLVAYSVKIETN---------ENNLESAKGLLDDLRNDLDRLF 592
++E DL+ L A SL A +K+ E+ +ES + +DL N L +
Sbjct: 1900 KKHELEMDLESLEAANQSLQA-DLKLAFKRIGDLQAAIEDEMESDEN--EDLINSLQDMV 1956
Query: 593 VKVEKIHEKV 602
K +K K+
Sbjct: 1957 TKYQKRKNKL 1966
Score = 57.4 bits (137), Expect = 4e-08
Identities = 108/558 (19%), Positives = 231/558 (41%), Gaps = 94/558 (16%)
Query: 132 EEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQA-------TFGTFESILRSSQHKQD 184
EE+QQ+R + ++R EL +E ++ L + T + +L + ++
Sbjct: 1261 EEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAERL 1320
Query: 185 LTEKAVKQGESEVSRISEVLQKLQNEILK-----------DLSDG-------IHVVKDAR 226
EK +K+ +++ + + ++ ++ E+++ ++ D + + R
Sbjct: 1321 RAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVR 1380
Query: 227 ERDFTSL----------------ENTVEERLTELTKSINDNIAIFTEVQKRSQKEINDMK 270
E DFT + +E RL +L ++ +++K+ Q+ +++
Sbjct: 1381 EVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQ 1440
Query: 271 AKVASLEESEGNKQDL------------KALKEAVKE-IQTSAKSREWDM-----EALRS 312
LE + +L +A +EA +E +Q RE DM +L+
Sbjct: 1441 DTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQ 1500
Query: 313 TLQTMESDIYTEVRELVSLKQEQQ--AFKEAADTERLA-----LQALTEKLLRSEESVSR 365
L+ + DI +++VSL+ E Q + +E+ D LA L+ L K+ EE +
Sbjct: 1501 QLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDE 1560
Query: 366 LPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQV 425
I+ LE+ +L+ + ++ HS+ E+ + + ++ Q + + M+V
Sbjct: 1561 QAGTIQMLEQAKLRLEMEMERMRQ----THSKEMES---RDEEVEEARQSCQKKLKQMEV 1613
Query: 426 ASARQTESLESLLSKSQEHEQRLAALQGRL--EGLGSSEADQDGLASTVRSLGETQLVL- 482
+ E + +L + +E E +LA L ++ S + + L T L + QL+L
Sbjct: 1614 QLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLD 1673
Query: 483 --------YGDVEELKRSVGELPST----VESLQKVQEQVHTL-LSQDQAQAARLPPQDF 529
++ +LK + E T V++ + ++ ++ L L D A+ ++
Sbjct: 1674 HLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQ 1733
Query: 530 LDRLSSLDN-LKASVSQVEADLKMLRTAVDSLVAYS----VKIETNENNLESAKGLLDDL 584
L RL N ++ + + + D+ L + VA + +I + LE A +L
Sbjct: 1734 LSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQEL 1793
Query: 585 RNDLDRLFVKVEKIHEKV 602
+ L L +VE + + +
Sbjct: 1794 QEKLQALQSQVEFLEQSM 1811
Score = 45.8 bits (107), Expect = 1e-04
Identities = 68/336 (20%), Positives = 141/336 (41%), Gaps = 26/336 (7%)
Query: 273 VASLEESEGNKQDLKALKEAVKEIQTSAKSREWDMEALRSTLQTMESDIYTEVRELVSLK 332
V L E + +++ ++ E ++++++ + E + LR +ES I EL +
Sbjct: 1243 VRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDER 1302
Query: 333 QEQQAFKEAADTERLALQALTEKLLRSEESVSRLPEEIRRLEEELRQLKSDSHGPKEDGG 392
++ + D E T + LR+E+ + L + L++++ ++ + E
Sbjct: 1303 NTGESASQLLDAE-------TAERLRAEKEMKELQTQYDALKKQMEVMEME---VMEARL 1352
Query: 393 FRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQVASARQTESLESLLSKSQEHEQRLAALQ 452
R +E + G + RL++ E V + R + E L Q+++++L
Sbjct: 1353 IRAAEINGEVDDDDAGGEWRLKY-ERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLE--- 1408
Query: 453 GRLEGLGSSEADQDGLASTVRSLGETQLVLYGDVEELKRSVGELPSTVESLQKVQEQVHT 512
LG +AD + ++ L + L ++++ K + L+K Q + +
Sbjct: 1409 ---RRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDS 1465
Query: 513 LLSQDQAQAARLPPQ-DFLDR-----LSSLDNLKASVSQVEADLKMLRTAVDSLVAYSVK 566
LSQ +A R Q + L R L+ +LK + + + D+ V SL A
Sbjct: 1466 ELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQD 1525
Query: 567 IETNENNLESAKGLLDDLRNDLDRLFVKVEKIHEKV 602
I + E+ E++ L ++ L L KV+ E++
Sbjct: 1526 ISSQESKDEAS---LAKVKKQLRDLEAKVKDQEEEL 1558
Score = 30.0 bits (66), Expect = 6.4
Identities = 24/101 (23%), Positives = 48/101 (47%), Gaps = 10/101 (9%)
Query: 132 EEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQA-------TFGTFESILRSSQHKQD 184
EE+ ++ R + SR++ EL L+ +E QSLQA G ++ + + + D
Sbjct: 1885 EEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAI-EDEMESD 1943
Query: 185 LTEKAVKQGESEVSRISEVLQKLQ--NEILKDLSDGIHVVK 223
E + + V++ + KL+ +++ +L D + VK
Sbjct: 1944 ENEDLINSLQDMVTKYQKRKNKLEGDSDVDSELEDRVDGVK 1984
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 69.7 bits (169), Expect = 7e-12
Identities = 98/490 (20%), Positives = 212/490 (43%), Gaps = 53/490 (10%)
Query: 132 EEVQQVRRSHQDFSRQREELGQGLQG----VEQKVQSLQATFGTFESILRSSQHKQDLTE 187
+E++++ + + EE Q LQ ++Q +Q L+ ES + Q ++ TE
Sbjct: 911 QELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTE 970
Query: 188 KAVKQGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKS 247
+K+ E E + + KL E K L D I +FT+ EE+ L K
Sbjct: 971 AKLKKLEEEQIILEDQNCKLAKE-KKLLEDRI--------AEFTTNLTEEEEKSKSLAKL 1021
Query: 248 INDNIAIFTEVQKRSQKEINDMKAKVASLEESEGNKQDLK----ALKEAVKEIQTSAKSR 303
N + A+ T++++R ++E + + + EG+ DL L+ + E++ +
Sbjct: 1022 KNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKK 1081
Query: 304 EWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESV 363
E +++A + ++ + ++++ L+ + +E ++ER + ++E+
Sbjct: 1082 EEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRN-------KAEKQK 1134
Query: 364 SRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEA---FEALQQKSQGLDSRLQHVEDGV 420
L EE+ L+ EL + +E R E + L+++++ ++++Q +
Sbjct: 1135 RDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKH 1194
Query: 421 LSMQVASARQTESLESLLSKSQEHEQRLAALQGR--------LEGLGSSEADQDGLASTV 472
A Q E + + + ++ +Q L +G L+G G SE + + + +
Sbjct: 1195 SQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQL 1254
Query: 473 RSLGETQLVLYGDVEELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDR 532
+ L V + + E ++ EL V LQ + V LLSQ +++++L +DF
Sbjct: 1255 QEL----QVKFNEGERVRT---ELADKVTKLQVELDNVTGLLSQSDSKSSKL-TKDF--- 1303
Query: 533 LSSLDNLKASVSQVEADLKMLRTAVDSLVAYSVKIETNENNLESAKGLLDDLRNDLDRLF 592
A SQ++ ++L+ ++ S K++ E+ S + L++ L
Sbjct: 1304 -------SALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLE 1356
Query: 593 VKVEKIHEKV 602
++ +H +V
Sbjct: 1357 KQIATLHAQV 1366
Score = 67.4 bits (163), Expect = 4e-11
Identities = 94/483 (19%), Positives = 192/483 (39%), Gaps = 56/483 (11%)
Query: 133 EVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVKQ 192
++Q+++ + R R EL KV LQ +L S K K
Sbjct: 1253 QLQELQVKFNEGERVRTELAD-------KVTKLQVELDNVTGLLSQSDSKSSKLTKDFSA 1305
Query: 193 GESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLEN-------------TVEE 239
ES++ E+LQ+ +N LS + V+D + LE T+
Sbjct: 1306 LESQLQDTQELLQE-ENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHA 1364
Query: 240 RLTELTKSINDNIAIFT---EVQKRSQKEINDM----KAKVASLEESEGNKQDLKALKEA 292
++ ++ K + D++ EV+++ QK++ + + KVA+ ++ E K L+ +
Sbjct: 1365 QVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDD 1424
Query: 293 VKEIQTSAKSREWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQAL 352
+ + ++E + + ++ T + + +A +T+ L+L
Sbjct: 1425 LLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARA 1484
Query: 353 TEKLLRSEESVSRLPEEIRRLEEELRQLKSD---SHGPKEDGGFRHSEAFEALQQKSQGL 409
E+ + + + RL ++ R E+L K D S E + E ++ + + L
Sbjct: 1485 LEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEEL 1544
Query: 410 DSRLQHVEDGVL----SMQVASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQ 465
+ LQ ED L ++Q A+ L+ +S+E +++L +E E Q
Sbjct: 1545 EDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQ 1604
Query: 466 DGLASTVRSLGETQLVLYGDVEELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQAARLP 525
+A R ++L+ + +L + ++S K +++ L + QAQ
Sbjct: 1605 RSMAVAAR-------------KKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQ----- 1646
Query: 526 PQDFLDRLSSLDNLKASVSQVEADLKMLRTAVDSLVAYSVKIETNENNLESAKGLLDDLR 585
D + LD+ +AS ++ A K + S+ A ++++ E AK R
Sbjct: 1647 ---MKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQER 1703
Query: 586 NDL 588
++L
Sbjct: 1704 DEL 1706
Score = 54.3 bits (129), Expect = 3e-07
Identities = 73/339 (21%), Positives = 141/339 (41%), Gaps = 39/339 (11%)
Query: 272 KVASLEESEGNKQDLKALKEA---VKEIQTSAKSREWDMEALRSTLQT----------ME 318
KV L + ++++ A +E V+E Q +A++R +ME L+S L E
Sbjct: 833 KVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAE 892
Query: 319 SDIYTEVREL-VSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSRLPEEIRRLEEEL 377
+++ E EL L ++Q +E ++ E+ + ++ + I+ LEE+L
Sbjct: 893 TELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQL 952
Query: 378 RQLKSDSHG------PKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQVASARQT 431
+ +S E + E L+ ++ L + +ED + +
Sbjct: 953 EEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEE 1012
Query: 432 ESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQLVLYGDVEELKR 491
E +SL +HE + L+ RL E + L T R L L + EL+
Sbjct: 1013 EKSKSLAKLKNKHEAMITDLEERLR---REEKQRQELEKTRRKLEGDSTDLSDQIAELQA 1069
Query: 492 SVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLSSLDNLKASVSQVEADLK 551
+ EL L K +E++ L++ + +AA+ L + L++ +S+++ DL+
Sbjct: 1070 QIAELKM---QLAKKEEELQAALARVEEEAAQKNM-----ALKKIRELESQISELQEDLE 1121
Query: 552 MLRTAVDSLVAYSVKIETNENNL-ESAKGLLDDLRNDLD 589
R + + K E + +L E + L +L + LD
Sbjct: 1122 SERASRN-------KAEKQKRDLGEELEALKTELEDTLD 1153
Score = 47.4 bits (111), Expect = 4e-05
Identities = 52/257 (20%), Positives = 109/257 (42%), Gaps = 17/257 (6%)
Query: 131 LEEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAV 190
+ E+ R S ++ Q +E + L+ +E ++ LQ E R +Q ++D +
Sbjct: 1651 MRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEI 1710
Query: 191 KQGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSIND 250
+ + E ++L+ I + L + + E+ T L N ++ IN
Sbjct: 1711 ANSSGKGALALEEKRRLEARIAQ-LEEELE-----EEQGNTELINDRLKKANLQIDQINT 1764
Query: 251 NIAIF-TEVQK----RSQKEINDMKAKVASLEESEGN-----KQDLKALKEAVKEIQTSA 300
++ + + QK R Q E + + KV L+E EG K + AL+ + +++
Sbjct: 1765 DLNLERSHAQKNENARQQLERQNKELKV-KLQEMEGTVKSKYKASITALEAKIAQLEEQL 1823
Query: 301 KSREWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSE 360
+ + +A ++ E + + ++ ++ + +K+ AD L+ L +L +E
Sbjct: 1824 DNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAE 1883
Query: 361 ESVSRLPEEIRRLEEEL 377
E R R+L+ EL
Sbjct: 1884 EEAQRANASRRKLQREL 1900
>gi|194353964 coiled-coil domain containing 157 [Homo sapiens]
Length = 752
Score = 69.3 bits (168), Expect = 9e-12
Identities = 78/314 (24%), Positives = 139/314 (44%), Gaps = 40/314 (12%)
Query: 269 MKAKVASLEESEGNKQDLKA----LKEAVKEIQTSAKSR---------EWDMEALRSTLQ 315
++A A LEE+EG K L+ L++A+K+ Q + + + EW+ + + L
Sbjct: 290 VEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEEDEQCLSEWEHD--KQQLL 347
Query: 316 TMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSRLPEEIRRLEE 375
T SD+ T++ L ++Q+ +A + + LQ E+ +E V +L E++++LE
Sbjct: 348 TETSDLKTKMATLERELKQQRESTQAVEAKAQQLQEEGERRAAAERQVQQLEEQVQQLEA 407
Query: 376 ELRQL----------------KSDSHGPKEDGGFRHSEAFEALQQKS-QGLDSRLQHVED 418
+++ L + D + D RH E+ +A Q+ + LDS Q E+
Sbjct: 408 QVQLLVGRLEGAGQQVCWASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQEREE 467
Query: 419 GVLSMQVASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGET 478
S+ A A++ E L S E EQ L+ + E L S + ++ GL L T
Sbjct: 468 LRGSLDEAEAQRARVEEQLQS---EREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLT 524
Query: 479 QLVLYGDVEELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQ-----DFLDRL 533
L L ++EELK L + + + + Q+H S P D ++R
Sbjct: 525 ILELERELEELKERERLLVAFPDLHRPTETQIHGGRSSSVESQITCPTDSGNVTDHMERQ 584
Query: 534 SSLDNLKASVSQVE 547
++++ V Q E
Sbjct: 585 VQANDIRIRVLQEE 598
>gi|31542634 filamin A interacting protein 1 [Homo sapiens]
Length = 1213
Score = 69.3 bits (168), Expect = 9e-12
Identities = 91/478 (19%), Positives = 206/478 (43%), Gaps = 51/478 (10%)
Query: 123 SGWCVHHVLEEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHK 182
SG H+ + R++ + +E+L Q L +E ++Q+ + +L++ + K
Sbjct: 52 SGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIMEGELQAREDVI----HMLKTEKTK 107
Query: 183 QDLTEKAVKQGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLT 242
++ E E E +VL+ L + + L+ + +D E+ + L+ +EE+
Sbjct: 108 PEVLEAHYGSAEPE-----KVLRVLHRDAI--LAQEKSIGEDVYEKPISELDR-LEEKQK 159
Query: 243 ELTKSINDNIAIFTEVQKRSQKEINDMKAKVAS-LEESEGNKQDLKALKEAVKEIQTSAK 301
E + + + + + + +R+ E+ + K K + +S+ L+ +E +K++ K
Sbjct: 160 ETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDFTNLLEQERERLKKLLEQEK 219
Query: 302 SREWDMEALRSTLQTMESDIYTEVREL-VSLKQEQQAFKEAADTERLALQALTEKLLRSE 360
+ + E + D +++ + L E+Q E + +Q LT+KL E
Sbjct: 220 AYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEE 279
Query: 361 ESVSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGV 420
E + + + + ++L +L+ D F H + Q+ + ++++L + E
Sbjct: 280 EKLKAITSKSKEDRQKLLKLEVD---------FEHKAS--RFSQEHEEMNAKLANQESHN 328
Query: 421 LSMQVASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQL 480
+++ T+ +E L ++ ++ LQ + + E L + V +L + L
Sbjct: 329 RQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVL 388
Query: 481 VLYGDVEELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDRLSSLDNLK 540
+ G EE+ ++ + E +K+QE+ H ++ RL + R+S L+ L+
Sbjct: 389 EMEGKDEEITKTESQCR---ELRKKLQEEEH------HSKELRLEVEKLQKRMSELEKLE 439
Query: 541 ASVSQVEADLKMLRTAVDSLVAYSVKIETNENNLESAKGLLDDLRNDLDRLFVKVEKI 598
+ S+ +++ L NLE K L DL N+L+ + +V+++
Sbjct: 440 EAFSKSKSECTQLHL-----------------NLEKEKNLTKDLLNELEVVKSRVKEL 480
Score = 53.1 bits (126), Expect = 7e-07
Identities = 83/462 (17%), Positives = 200/462 (43%), Gaps = 63/462 (13%)
Query: 132 EEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVK 191
EE+ + + +RQ L L G+ Q+++ L+ T +++ ++ + Q+L +K K
Sbjct: 315 EEMNAKLANQESHNRQ---LRLKLVGLTQRIEELEETN---KNLQKAEEELQELRDKIAK 368
Query: 192 QGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDN 251
GE S + ++ L+ +L+ + ++ + T E+ E +L + + +
Sbjct: 369 -GECGNSSLMAEVENLRKRVLE---------MEGKDEEITKTESQCRELRKKLQEEEHHS 418
Query: 252 IAIFTEVQKRSQKEINDMKAKVASLEESEGN--------KQDLKALKEAVKEIQTSAKSR 303
+ EV+K QK +++++ + +S+ +++ K+ + E++ KSR
Sbjct: 419 KELRLEVEKL-QKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEV-VKSR 476
Query: 304 EWDMEALRSTLQTMESDIYTEVRELVS---------------LKQEQQ---AFKEAADTE 345
++E S L+ E + ++ +L S +KQE++ + E
Sbjct: 477 VKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVE 536
Query: 346 RLALQALTEKLLRSEESVSRLPEEI--------RRLEEELRQLKSDSHGPKEDGGFRHSE 397
+ + +TEKL+ + + +L E+ R +E + +LKS+ E+ S
Sbjct: 537 QGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSE-----EEKSSELSC 591
Query: 398 AFEALQQKSQGLDSRLQHVEDG-VLSMQVASARQTESLESLLSKSQEHEQRLAALQGRLE 456
+ + L+++ G++ + + G + + ++ L + + ++RL L+
Sbjct: 592 SVDLLKKRLDGIEEVEREITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEG 651
Query: 457 GLGSSEADQDGLASTVRSLGETQLVLYGDVEELKRSVGELPSTVESLQKVQEQVHT---- 512
L +E + D L R+ + L +EE+K + + +E + V ++
Sbjct: 652 DLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQIAK-NKAIEKGEVVSQEAELRHRF 710
Query: 513 LLSQDQAQAARLPPQDFLDRLSSLDNLKASVSQVEADLKMLR 554
L + +++ + Q +++ L N + +SQ++ D +L+
Sbjct: 711 RLEEAKSRDLKAEVQALKEKIHELMNKEDQLSQLQVDYSVLQ 752
Score = 30.8 bits (68), Expect = 3.7
Identities = 43/207 (20%), Positives = 91/207 (43%), Gaps = 20/207 (9%)
Query: 143 DFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQH-KQDLTEKAVKQGES----EV 197
+ +R+R+EL L+ E+K L + + L + ++++T ++G E
Sbjct: 567 NLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPED 626
Query: 198 SRISEVLQKLQNEILKDLSDGIHVVKD---ARERDFTSLEN---TVEERLTELTKSINDN 251
++I E+ L+ E LK + VV+ E ++ LE T +++ L++ + +
Sbjct: 627 NKIKELT--LEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEE- 683
Query: 252 IAIFTEVQKRSQKEINDMKAKVASLEE----SEGNKQDLKALKEAVKEIQTSAKSREWDM 307
I ++ K E ++ ++ A L E +DLKA +A+KE ++E +
Sbjct: 684 --IKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHELMNKEDQL 741
Query: 308 EALRSTLQTMESDIYTEVRELVSLKQE 334
L+ ++ E + ++ QE
Sbjct: 742 SQLQVDYSVLQQRFMEEENKNKNMGQE 768
>gi|34577114 cytomatrix protein p110 [Homo sapiens]
Length = 957
Score = 68.9 bits (167), Expect = 1e-11
Identities = 121/623 (19%), Positives = 242/623 (38%), Gaps = 107/623 (17%)
Query: 55 PQQHPQNQAHGKGGHR----GGGGGGGKSSSSSSASAAAAAAAASSSASCS--------- 101
P + P+ + GHR GGGGG GK+ S + + AA A S S
Sbjct: 15 PSRSPRLPRSPRLGHRRTSSGGGGGTGKTLSMENIQSLNAAYATSGPMYLSDHEGVASTT 74
Query: 102 -----RRLGRALNFLFYLALVAAAAFSGWCVHHVLEEVQQVRRSHQDFSRQREELGQGLQ 156
LGRA N Y V A S + SH D ++ G GL
Sbjct: 75 YPKGTMTLGRATNRAVYGGRVTAMGSS--------PNIASAGLSHTDVLSYTDQHG-GLT 125
Query: 157 GV----EQKVQSL-----QATFGTFESILRSSQHKQDLTEKAVKQGESEVSRISEVLQKL 207
G +V S+ +T ++ L+ Q + DL K + +S++ ++
Sbjct: 126 GSSHHHHHQVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTF 185
Query: 208 QNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDNIAIFTEV---QKRSQK 264
+ LK K+ R + +V + ++ N ++ + + + R+Q+
Sbjct: 186 WSPELK---------KERVLRKEEAARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQR 236
Query: 265 EINDMKAKVASLEESEGNKQ----DLKALKEAVKEIQTSAKSREWDMEALRSTLQTMESD 320
++N + L++ GN+ ++ +E + +Q + ++ LR TL+ ME
Sbjct: 237 DLNHL------LQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELR 290
Query: 321 IYTEVRELVSLKQEQQAFKEAADTERLALQAL------TEKLLRSEESVSRLPEEIRRLE 374
I T+ + L + + + E ++ L ++L T ++ +E VS L + + E
Sbjct: 291 IETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKE 350
Query: 375 EELRQLKSDSH-----GPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQVASAR 429
+E L+ + H P+ E K L+ ++ +ED + ++
Sbjct: 351 KENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVL 410
Query: 430 QTE---------------------SLESLLSKSQEHEQRLAALQGRLEGLGSSEAD---- 464
TE ++ L + + E L ALQ +LE L + +D
Sbjct: 411 NTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQH 470
Query: 465 QDGLASTVRSLGETQLVLYGDVEELKRSVGE----LPSTVESLQKVQEQVHTLLSQ--DQ 518
+ L ++ + + +L +V+ L+ + E L + LQ + E+ TL + D
Sbjct: 471 IEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDM 530
Query: 519 AQAARLPPQDFLDRLSSLDNLKASVSQVEADLKMLRTAVDSLVAYSVKIETNENNLESAK 578
+ + ++NL+ + + L L+ V SL +T+ +N ++A
Sbjct: 531 KDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSL-------QTDSSNTDTAL 583
Query: 579 GLLDDLRNDLDRLFVKVEKIHEK 601
L++ ++ +R+ ++++ E+
Sbjct: 584 ATLEEALSEKERIIERLKEQRER 606
Score = 67.0 bits (162), Expect = 5e-11
Identities = 80/412 (19%), Positives = 183/412 (44%), Gaps = 23/412 (5%)
Query: 174 SILRSSQHKQDLTEKAVKQGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSL 233
S L+ K + ++ +++++ + ++ L++EI ++G+ +D RE + +
Sbjct: 364 SQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTED-REEEIKQI 422
Query: 234 ENTVEERLTELTKSINDNIAIFTEVQKRSQKEINDMKAKVASLEESEGN-KQDLKALKEA 292
E V + ++ K+ D + E+ K+ + E+ ++ K+ +L + KQ ++ LKE+
Sbjct: 423 E--VYKSHSKFMKTKIDQLK--QELSKK-ESELLALQTKLETLSNQNSDCKQHIEVLKES 477
Query: 293 VKEIQTSAKSREWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQAL 352
+ + A + +++ALR L+ ES + + ++L L +E+ + L+
Sbjct: 478 LTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVK 537
Query: 353 TEKLLRSEESVSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSR 412
K+ ++ + L E++R +++L LK + D S AL + L +
Sbjct: 538 ERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDS----SNTDTALATLEEALSEK 593
Query: 413 LQHVEDGVLSMQVASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTV 472
+ +E + + E +ES ++++ ++++ ALQ L SS D AS++
Sbjct: 594 ERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSL 653
Query: 473 RSLGETQLVLYGDVEELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQAARLPPQDFLDR 532
S G L ++ L+ ++ + L+ ++ H + +R+ P +F D+
Sbjct: 654 ASAG---LKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNI-----EDDSRMNP-EFADQ 704
Query: 533 LSSLDNLKASVSQVEADLKMLRTAVDSLVAYSVKIETNENNLESAKGLLDDL 584
+ LD S + + VD L+ ++E +N+ + L+ L
Sbjct: 705 IKQLDK---EASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESL 753
Score = 48.9 bits (115), Expect = 1e-05
Identities = 63/292 (21%), Positives = 124/292 (42%), Gaps = 43/292 (14%)
Query: 131 LEEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAV 190
LEE++ R+ ++D + L L E + L+ + S K E A+
Sbjct: 612 LEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAI 671
Query: 191 KQGESEVSRISEVLQKLQN-----EILKDLSDGIHVV-KDARE-RDFTSLENTVEERLTE 243
+Q + E S++ L+K N + + +D I + K+A RD +RL E
Sbjct: 672 EQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLE 731
Query: 244 LTKSI----NDNIAIFTEVQKRSQKEINDMKAKVASLEESE--GNKQDLKALKEA----- 292
+ K + ND E++ + + + D KVA+L+ ++ K++ + L+E
Sbjct: 732 ILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRRED 791
Query: 293 ----------VKEIQTSAKSREWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKE-- 340
++E+ + + +++A ++ L + + + + L +L+ E++ E
Sbjct: 792 SMADNSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEI 851
Query: 341 ---------AADTERLALQALTE----KLLRSEESVSRLPEEIRRLEEELRQ 379
AA +E+ A AL E K +++E V L E RL +L+Q
Sbjct: 852 LEMKQEALLAAISEKDANIALLELSASKKKKTQEEVMALKREKDRLVHQLKQ 903
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 68.6 bits (166), Expect = 2e-11
Identities = 89/435 (20%), Positives = 180/435 (41%), Gaps = 76/435 (17%)
Query: 195 SEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSL---ENTVEERLTELTKSINDN 251
SE+ + +++L+ EI +D S+ +H++ +++ F+ + E+ V+ L E+ K+ D+
Sbjct: 747 SELKSLPSEVERLRKEI-QDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKT-KDD 804
Query: 252 IAIFTEVQKRSQKEINDMKAKVAS--------LEESEGNKQDLKALKEAVKEIQTSAKSR 303
+A K + +E + K LEE+E Q++ L + ++ +S +
Sbjct: 805 LATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGAL 864
Query: 304 EWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESV 363
+ ++ LQ ++ + E+ LK++ + T +TEKL ++ E V
Sbjct: 865 KTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEV 924
Query: 364 SRLPEE---IRRLEEELR----QLKSDSHGPKE-------------DGGFRHSEAFEALQ 403
L +E +++L+E L+ QLKSD H + +H E L+
Sbjct: 925 KTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLK 984
Query: 404 QKSQGLDSRLQHVED--------------GVLSMQVASARQTESLE-------------- 435
K SR H+E+ G+ Q A+ T++L
Sbjct: 985 SKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRK 1044
Query: 436 --SLLSKSQEHEQRLAALQGRLEGLGS--------SEADQDGLASTVRSLGETQLVLYGD 485
SL+ + E +Q L ++ E L + + +Q+ L L + Q ++ +
Sbjct: 1045 IFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQE 1104
Query: 486 VEELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQAARL-----PPQDFLDRLSSLDNLK 540
+ GEL T + L +V+E++ Q Q + +L + +++ ++NLK
Sbjct: 1105 KNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLK 1164
Query: 541 ASVSQVEADLKMLRT 555
+ E L+ + T
Sbjct: 1165 NELKNKELTLEHMET 1179
Score = 59.7 bits (143), Expect = 8e-09
Identities = 91/513 (17%), Positives = 213/513 (41%), Gaps = 55/513 (10%)
Query: 129 HVLEEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEK 188
++ E+ +R + + E+L + +E K++ + FE++ R ++ Q++
Sbjct: 495 NIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKE-KNDLDEFEALERKTKKDQEM--- 550
Query: 189 AVKQGESEVSRISEVLQKLQ---NEILKDLSDGIHVVKDARERDFTSLENTVEERLTELT 245
Q E+S + +++ + ++ +LS + ++++ ++ E ++L +
Sbjct: 551 ---QLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIK 607
Query: 246 KSINDNIAIFTEVQKRSQKEINDMKAKVASLEESEGNKQDLKALKEAVKEIQTSAKSREW 305
++ ++ + ++ Q + + + ES + + LKE +KE+ T+ K E
Sbjct: 608 MDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMEN 667
Query: 306 DMEALRSTLQT---MESDI-------YTEVRELVSL--------------------KQEQ 335
D++ +S L+ M+ D+ + E+ +L SL ++
Sbjct: 668 DIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQK 727
Query: 336 QAFKEAADTERLALQALTEKLLRSEESVSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRH 395
+ KE + E L E +L SE + LP E+ RL +E++ + H +
Sbjct: 728 ELNKEVEENEALR----EEVILLSE--LKSLPSEVERLRKEIQDKSEELHIITSEKDKLF 781
Query: 396 SEAFEALQQKSQGLDSRLQHVEDGVLSMQVASARQTESLESLLSKSQEHEQRLAALQGRL 455
SE + + QGL + +D + + Q + ++ + + EQ+ +
Sbjct: 782 SEVVHK-ESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEEN 840
Query: 456 EGLGSSEADQDGLASTV-RSLGETQLVLYGDVEELKRSVGELPSTVESLQKVQEQVH--- 511
E + + A SLG + L +EL+ E+ + +++++EQ+
Sbjct: 841 ERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRD 900
Query: 512 -TLLSQDQAQAARLPP-QDFLDRLSSLDNLKASVSQVEADLKMLRTAVDSLVAYSVKIET 569
TL + ++ + Q L+ + +L K + Q++ L++ R + S + +V +
Sbjct: 901 STLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNM-- 958
Query: 570 NENNLESAKGLLDDLRNDLDRLFVKVEKIHEKV 602
N + E + L+ L+ + + KI E+V
Sbjct: 959 NIDTQEQLRNALESLKQHQETINTLKSKISEEV 991
Score = 59.3 bits (142), Expect = 1e-08
Identities = 101/524 (19%), Positives = 231/524 (44%), Gaps = 89/524 (16%)
Query: 132 EEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVK 191
E+ Q+ + + +++R+ L + +E K L+ + ++ SQ KQ+ + +K
Sbjct: 1335 EKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLN-MK 1393
Query: 192 QGESEVSRI----------SEVLQKLQNEIL---KDLSDGIHVVKD-ARER-DFTSLENT 236
+ ++E ++I L +++ E+L K L + +K A+E+ D L+
Sbjct: 1394 EKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEV 1453
Query: 237 VEERLTELTKSINDNIAIFTEVQKRSQKEINDMKAKVASLEESEGNKQDLKA-LKEAVKE 295
++ +L ++I + +A E ++ ++K L+E E +L+ L E E
Sbjct: 1454 LQSESDQLKENIKEIVAKHLETEE-------ELKVAHCCLKEQEETINELRVNLSEKETE 1506
Query: 296 IQTSAKSREWDMEALRSTLQTMESDIYTEVRELVSLKQ---------EQQAFKEAADTER 346
I T K +EA+ LQ +IY E E ++KQ E + FKE +
Sbjct: 1507 ISTIQK----QLEAINDKLQNKIQEIY-EKEEQFNIKQISEVQEKVNELKQFKEHRKAKD 1561
Query: 347 LALQALTEKLLRSEESVSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKS 406
ALQ++ K+L + EEI+ + +E ++K EALQ +
Sbjct: 1562 SALQSIESKMLELTNRLQESQEEIQIMIKEKEEMK---------------RVQEALQIER 1606
Query: 407 QGLDSRLQHVEDGVLSMQVASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQD 466
D ++ ++ V M+ + ++ + L+ ++ E ++++ ++ E + + + +
Sbjct: 1607 ---DQLKENTKEIVAKMKESQEKEYQFLK--MTAVNETQEKMCEIEHLKEQFETQKLNLE 1661
Query: 467 GLASTVRSLGETQLVLYGDVEELK---RSVGELPSTVESLQKVQEQVHTLLSQ------D 517
+ + ++ TQ +L+ ++EE++ + +L S E+L+ ++Q+ L + +
Sbjct: 1662 NIET--ENIRLTQ-ILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLE 1718
Query: 518 QAQAARLPPQDFLDRLSSLDNLKASVSQVEADL----KMLRTAVDSLVAYSVKIE----- 568
+ + ++ + ++D L+ VS+ ++ K L + D+L A +KI+
Sbjct: 1719 KQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRI 1778
Query: 569 ------TNENNLESAKGLLDDLRNDLDRLFVKVE----KIHEKV 602
+ ++ +G++ + + L + +E K+ EK+
Sbjct: 1779 AHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKI 1822
Score = 52.0 bits (123), Expect = 2e-06
Identities = 94/485 (19%), Positives = 209/485 (43%), Gaps = 57/485 (11%)
Query: 145 SRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVKQGESEVS-RISEV 203
S++ +E ++ V ++ LQ +S S Q K+++ E K E+E +++
Sbjct: 1427 SKRLQESHDEMKSVAKEKDDLQRLQEVLQS--ESDQLKENIKEIVAKHLETEEELKVAHC 1484
Query: 204 LQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDNIAIFTEVQKRSQ 263
K Q E + +L V +E + ++++ +E +L I + I+ + ++ +
Sbjct: 1485 CLKEQEETINEL----RVNLSEKETEISTIQKQLEAINDKLQNKIQE---IYEKEEQFNI 1537
Query: 264 KEINDMKAKVASLEESEGNKQDLKALKEAVKEIQTSAKSREWDMEALRSTLQTMESDIYT 323
K+I++++ KV +LK KE K ++ +S E M L + LQ + +I
Sbjct: 1538 KQISEVQEKV----------NELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQI 1587
Query: 324 EVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEE---------SVSRLPE---EIR 371
++E +K+ Q+A + D + + + K+ S+E +V+ E EI
Sbjct: 1588 MIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIE 1647
Query: 372 RLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSR--LQHVEDGVLSMQVASAR 429
L+E+ K + + + E L++ R L+ VE+ +++V +
Sbjct: 1648 HLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEE---TLKVERDQ 1704
Query: 430 QTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLASTVRSLGETQLVLYGDVEEL 489
E+L +++ E ++ L + L + Q+ + + E + ++L
Sbjct: 1705 LKENLRETITRDLEKQEELKIVHMHL------KEHQETIDKLRGIVSEKTNEISNMQKDL 1758
Query: 490 KRSVGELPSTVESLQKVQEQVHTLLSQDQAQAARLP--PQDFLDRLSSLD-NLKASVSQV 546
+ S L + +Q+ H L + Q +L + D+LS++ +L+ S +++
Sbjct: 1759 EHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKL 1818
Query: 547 EADLKMLRTAVDSLVAYSVKIETNE-----NNLESAKGLLDDLRNDLDRLFVK----VEK 597
+ ++ L+ L+ ++K + NE + +E K + D L +L ++ +K
Sbjct: 1819 QEKIQELKANEHQLI--TLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQK 1876
Query: 598 IHEKV 602
+HE +
Sbjct: 1877 LHENL 1881
Score = 47.4 bits (111), Expect = 4e-05
Identities = 60/334 (17%), Positives = 149/334 (44%), Gaps = 25/334 (7%)
Query: 131 LEEVQQVRRSHQDFSRQREELGQGLQGV----EQKVQSLQATFGTFESILRSSQHKQDLT 186
LE+ ++++ H +E + + L+G+ ++ ++Q L++ K
Sbjct: 1717 LEKQEELKIVHMHLKEHQETIDK-LRGIVSEKTNEISNMQKDLEHSNDALKAQDLK---I 1772
Query: 187 EKAVKQGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEE------R 240
++ ++ + E + KL+ I+ + +D + ++ E L+ ++E +
Sbjct: 1773 QEELRIAHMHLKEQQETIDKLRG-IVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQ 1831
Query: 241 LTELTKSINDNIAIFTEVQKRSQKEINDMKAKVASLEESEGN-----KQDLKALKEAVKE 295
L L K +N+ +E+++ +K+I D ++ LE N ++L+ +K +KE
Sbjct: 1832 LITLKKDVNETQKKVSEMEQL-KKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKE 1890
Query: 296 ---IQTSAKSREWDMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQAL 352
++ ++ + + + L+ +LQ ++ +EL + + + KE D R +
Sbjct: 1891 RDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEK 1950
Query: 353 TEKLLRSEESVSRLPEEIRRLEEELRQLKSDSHGPKEDGGFRHSEAFEALQQKSQGLDSR 412
T ++ ++ + + +E+++ +EL++ + KED H + E Q K Q
Sbjct: 1951 TIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQN 2010
Query: 413 LQHVEDGVLSMQVASARQTESLESLLSKSQEHEQ 446
L + + Q+ + + ESLE + ++E ++
Sbjct: 2011 LSMQSVRMDNFQL-TKKLHESLEEIRIVAKERDE 2043
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 68.6 bits (166), Expect = 2e-11
Identities = 115/492 (23%), Positives = 193/492 (39%), Gaps = 68/492 (13%)
Query: 132 EEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVK 191
EE++ VR + RQR G E ++Q+L+A E+ R +Q + + + V
Sbjct: 1452 EEIRVVRLQLEATERQRG-------GAEGELQALRARAEEAEAQKRQAQEEAERLRRQV- 1503
Query: 192 QGESEVSRISEV----LQKLQNEILKDLSDGIHVVKDAR------ERDFTSLE----NTV 237
Q ES+ R +EV K + E ++ + +++ R ER E V
Sbjct: 1504 QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1563
Query: 238 EERLTELTKSINDNI----AIFTEVQKRSQKEINDMKAKVASLEESEGNKQDLKALKEAV 293
+ L +S + A F E + ++ + + VA L E + +A E
Sbjct: 1564 QVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1623
Query: 294 KEIQTSAKSREWDM---EALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQ 350
+E + + W + EALR LQ E + + + KQ+++A +EA + Q
Sbjct: 1624 RE-EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1682
Query: 351 ALTEKLLRSEE-----------SVSRL--PEEIRRLEEELRQLKSDSHGPKEDGGFRHSE 397
A+ ++ L +E + RL +E+ RL E Q + +E+ E
Sbjct: 1683 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1742
Query: 398 AFEALQQKSQGLDSRLQHVEDGVLSMQVASARQTESLESLLSKSQEHEQRLAALQGRLEG 457
A A QK Q L++ L V M+V A + + E S S++ +QRL A GR
Sbjct: 1743 A-AAATQKRQELEAELAKVR---AEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1798
Query: 458 LGSSEADQDGLASTV---RSLGETQLVLYGDVEELKRSVGELPSTVESLQKVQEQVHTLL 514
L A LA R L E E +R + E + + +++ + L
Sbjct: 1799 LAEEAARLRALAEEAKRQRQLAEEDAA--RQRAEAERVLAEKLAAIGEATRLKTEAEIAL 1856
Query: 515 SQDQAQ---AARLPPQDFLDRLSSLDNLKASVSQVEADLKMLRTAVDSLVAYSVKIETNE 571
+ +A+ RL + R + + +E L LR A DS
Sbjct: 1857 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS------------ 1904
Query: 572 NNLESAKGLLDD 583
LE KGL++D
Sbjct: 1905 -ELERQKGLVED 1915
Score = 56.6 bits (135), Expect = 6e-08
Identities = 109/482 (22%), Positives = 188/482 (39%), Gaps = 67/482 (13%)
Query: 132 EEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVK 191
EE ++R ++ RQR+ + Q+ ++ + +I +++ K + E A+K
Sbjct: 1801 EEAARLRALAEEAKRQRQLAEE--DAARQRAEAERVLAEKLAAIGEATRLKTE-AEIALK 1857
Query: 192 QGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDN 251
+ E+E NE L+ L++ + E + +EERL +L K+ +
Sbjct: 1858 EKEAE------------NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 1905
Query: 252 I----AIFTEVQKRSQKEINDMKAKVASLEESEGNKQDLK-ALKEAVKEIQTSAKSREW- 305
+ + + ++ ++ ++ A AS E++ K +L+ L + + +S+E
Sbjct: 1906 LERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA 1965
Query: 306 DMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSR 365
++EA R E + RE Q+ A +E A +R A E+L E R
Sbjct: 1966 ELEAARQRQLAAEEE--RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2023
Query: 366 LPEEIRRLEEELRQLK-SDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSM- 423
L E R +E RQL+ + K + AF A+QQK Q L LQ E VL
Sbjct: 2024 LRE--RAEQESARQLQLAQEAAQKRLQAEEKAHAF-AVQQKEQELQQTLQQ-EQSVLDQL 2079
Query: 424 ------------------------QVASARQTESLESLLSKSQEHEQRLAALQGRLEGLG 459
S RQ E E L ++E Q A Q E L
Sbjct: 2080 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL- 2138
Query: 460 SSEADQDGLASTVRSLGETQLVLYGDVEELKRSVGELPSTVESLQKVQEQVHTLLSQDQA 519
EA+Q+ + D E+++ T+ +V++++ TL Q +
Sbjct: 2139 RKEAEQEAARRAQAEQAALRQKQAADA-EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2197
Query: 520 QAARLPPQDFLDRLSSLDNLKASV-------SQVEADLKMLRTAVDSLVAYSVKIETNEN 572
+ ++ LD L LKA SQVE +L +R ++ L +IE
Sbjct: 2198 TDHQ---KNLLD--EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2252
Query: 573 NL 574
L
Sbjct: 2253 AL 2254
Score = 54.3 bits (129), Expect = 3e-07
Identities = 103/504 (20%), Positives = 186/504 (36%), Gaps = 83/504 (16%)
Query: 131 LEEVQQVR-RSHQDFSRQREELGQGLQ------------GVEQKVQSLQATFGTFESILR 177
+EE +++R R+ Q+ +RQ + + Q V+QK Q LQ T +S+L
Sbjct: 2018 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2077
Query: 178 SSQHKQDLTEKAVKQG-ESEVSRISEVLQ-KLQNEILKDLSDGIHVVKDARERDFTSLEN 235
+ + + +A ++ E+ V E Q + Q E + L AR + + E
Sbjct: 2078 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2137
Query: 236 TVEERLTELTKSINDNIAIFTEVQKRSQKEINDMKAKVASLEESEGNKQDLKALKEAVKE 295
+E E + A + Q + K +L + +Q+L L+ ++E
Sbjct: 2138 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2197
Query: 296 IQTSAKSREWDMEAL----------RSTLQTMESDIYTEVRELVSLKQEQQAFKEA---- 341
+ +++ L RS ++ + ++ EL LK +A A
Sbjct: 2198 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2257
Query: 342 -ADTERLALQALTEKLLRSEESVSRL---PEEIRRL----EEELRQ--------LKSDSH 385
D + LQ EK+ + E +RL +E RL EE+L Q LK
Sbjct: 2258 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2317
Query: 386 GPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQVASARQTESLESLLSKSQEHE 445
+E R E LQQ+ + + + +++ M A +T+ + L ++ +
Sbjct: 2318 AVQE--ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2375
Query: 446 QRLAALQGRLE--------GLGSSEADQDGLASTVRSLGE----TQLVLY---------- 483
++A RL+ +E D +GE T+L
Sbjct: 2376 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2435
Query: 484 -------GDVEELKRSVGELPSTVESLQK-------VQEQVHTLLSQDQAQAARLPPQDF 529
D E L+ ++ EL E LQ+ E++ T+ + Q + Q F
Sbjct: 2436 IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF 2495
Query: 530 LDRLSSLDNLKASVSQVEADLKML 553
L SL + + Q +A L+ L
Sbjct: 2496 LSEKDSLLQRERFIEQEKAKLEQL 2519
Score = 52.0 bits (123), Expect = 2e-06
Identities = 74/337 (21%), Positives = 132/337 (39%), Gaps = 31/337 (9%)
Query: 142 QDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVKQGESEVSRI- 200
Q F +Q EE+G+ L E Q T E + S H + +A+ + E E ++
Sbjct: 2404 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2463
Query: 201 ---------SEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDN 251
SE +Q +Q E L + + + + E +E+ +L + D
Sbjct: 2464 QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2523
Query: 252 IAIFTEVQKRSQKEINDMKAK----VASLEESEGNKQDL-KALKEAVKEIQTSAKSREWD 306
+A ++++ Q++ M+ + VAS+EE+ + + + ++ +E+Q + R
Sbjct: 2524 VAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2583
Query: 307 MEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSRL 366
E L Q +RE + L +EQ A E A Q K L +
Sbjct: 2584 EELLAEENQ--------RLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDG 2635
Query: 367 PEEIRRLEEELRQLKSDSHGPK-EDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQV 425
P E L+ + ++ G +E + L Q +D L ED +Q
Sbjct: 2636 PAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVD-ELARREDVRHYLQG 2694
Query: 426 ASARQTESLESLLSKSQEHEQRL-AALQGRLEGLGSS 461
S S+ LL K+ + + AALQ +L G++
Sbjct: 2695 RS-----SIAGLLLKATNEKLSVYAALQRQLLSPGTA 2726
Score = 45.1 bits (105), Expect = 2e-04
Identities = 79/410 (19%), Positives = 164/410 (40%), Gaps = 55/410 (13%)
Query: 133 EVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQAT-FGTFESILRSSQHKQDLTEKAVK 191
E++Q+ R + + + LG LQ ++ + +QA +++ + +Q L E+ +
Sbjct: 1201 ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIER 1260
Query: 192 QGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDN 251
GE E Q+ + + + D E + + +E + K
Sbjct: 1261 HGEKV-----EECQRFAKQYINAIKD--------YELQLVTYKAQLEPVASPAKKP---- 1303
Query: 252 IAIFTEVQKRSQKEIND-MKAKVASLEESEGNKQDLKALKEAVKEIQTSAKSREWDMEAL 310
+VQ S+ I + + + E + Q +K + E ++ ++ + E
Sbjct: 1304 -----KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE 1358
Query: 311 RSTLQTMESDIYTEVRELVSL--KQEQQAFKEAADTERLALQALTEKLLRSEESVSRLPE 368
R L +E+ + + R+L + + QA +EA + + Q + E+++R EE+ +
Sbjct: 1359 RERLAEVEAALEKQ-RQLAEAHAQAKAQAEREAKELQ----QRMQEEVVRREEAAVDAQQ 1413
Query: 369 EIRRLEEELRQLKSDSHGPKEDGGFRHSEA------------------FEALQQKSQGLD 410
+ R ++EEL+QL+ S + R +EA EA +++ G +
Sbjct: 1414 QKRSIQEELQQLRQSSEA-EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAE 1472
Query: 411 SRLQHVEDGVLSMQVASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLAS 470
LQ + + + E E L + Q+ QR Q +E +A+ +
Sbjct: 1473 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR--KRQAEVELASRVKAEAEAARE 1530
Query: 471 TVRSLGETQLVLYGDVEELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQ 520
R+L + L EE +R + + + VE ++VQ + T +A+
Sbjct: 1531 KQRALQALE-ELRLQAEEAERRLRQ--AEVERARQVQVALETAQRSAEAE 1577
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 68.6 bits (166), Expect = 2e-11
Identities = 115/492 (23%), Positives = 193/492 (39%), Gaps = 68/492 (13%)
Query: 132 EEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVK 191
EE++ VR + RQR G E ++Q+L+A E+ R +Q + + + V
Sbjct: 1456 EEIRVVRLQLEATERQRG-------GAEGELQALRARAEEAEAQKRQAQEEAERLRRQV- 1507
Query: 192 QGESEVSRISEV----LQKLQNEILKDLSDGIHVVKDAR------ERDFTSLE----NTV 237
Q ES+ R +EV K + E ++ + +++ R ER E V
Sbjct: 1508 QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1567
Query: 238 EERLTELTKSINDNI----AIFTEVQKRSQKEINDMKAKVASLEESEGNKQDLKALKEAV 293
+ L +S + A F E + ++ + + VA L E + +A E
Sbjct: 1568 QVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1627
Query: 294 KEIQTSAKSREWDM---EALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQ 350
+E + + W + EALR LQ E + + + KQ+++A +EA + Q
Sbjct: 1628 RE-EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1686
Query: 351 ALTEKLLRSEE-----------SVSRL--PEEIRRLEEELRQLKSDSHGPKEDGGFRHSE 397
A+ ++ L +E + RL +E+ RL E Q + +E+ E
Sbjct: 1687 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1746
Query: 398 AFEALQQKSQGLDSRLQHVEDGVLSMQVASARQTESLESLLSKSQEHEQRLAALQGRLEG 457
A A QK Q L++ L V M+V A + + E S S++ +QRL A GR
Sbjct: 1747 A-AAATQKRQELEAELAKVR---AEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1802
Query: 458 LGSSEADQDGLASTV---RSLGETQLVLYGDVEELKRSVGELPSTVESLQKVQEQVHTLL 514
L A LA R L E E +R + E + + +++ + L
Sbjct: 1803 LAEEAARLRALAEEAKRQRQLAEEDAA--RQRAEAERVLAEKLAAIGEATRLKTEAEIAL 1860
Query: 515 SQDQAQ---AARLPPQDFLDRLSSLDNLKASVSQVEADLKMLRTAVDSLVAYSVKIETNE 571
+ +A+ RL + R + + +E L LR A DS
Sbjct: 1861 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS------------ 1908
Query: 572 NNLESAKGLLDD 583
LE KGL++D
Sbjct: 1909 -ELERQKGLVED 1919
Score = 56.6 bits (135), Expect = 6e-08
Identities = 109/482 (22%), Positives = 188/482 (39%), Gaps = 67/482 (13%)
Query: 132 EEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVK 191
EE ++R ++ RQR+ + Q+ ++ + +I +++ K + E A+K
Sbjct: 1805 EEAARLRALAEEAKRQRQLAEE--DAARQRAEAERVLAEKLAAIGEATRLKTE-AEIALK 1861
Query: 192 QGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDN 251
+ E+E NE L+ L++ + E + +EERL +L K+ +
Sbjct: 1862 EKEAE------------NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 1909
Query: 252 I----AIFTEVQKRSQKEINDMKAKVASLEESEGNKQDLK-ALKEAVKEIQTSAKSREW- 305
+ + + ++ ++ ++ A AS E++ K +L+ L + + +S+E
Sbjct: 1910 LERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA 1969
Query: 306 DMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSR 365
++EA R E + RE Q+ A +E A +R A E+L E R
Sbjct: 1970 ELEAARQRQLAAEEE--RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2027
Query: 366 LPEEIRRLEEELRQLK-SDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSM- 423
L E R +E RQL+ + K + AF A+QQK Q L LQ E VL
Sbjct: 2028 LRE--RAEQESARQLQLAQEAAQKRLQAEEKAHAF-AVQQKEQELQQTLQQ-EQSVLDQL 2083
Query: 424 ------------------------QVASARQTESLESLLSKSQEHEQRLAALQGRLEGLG 459
S RQ E E L ++E Q A Q E L
Sbjct: 2084 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL- 2142
Query: 460 SSEADQDGLASTVRSLGETQLVLYGDVEELKRSVGELPSTVESLQKVQEQVHTLLSQDQA 519
EA+Q+ + D E+++ T+ +V++++ TL Q +
Sbjct: 2143 RKEAEQEAARRAQAEQAALRQKQAADA-EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2201
Query: 520 QAARLPPQDFLDRLSSLDNLKASV-------SQVEADLKMLRTAVDSLVAYSVKIETNEN 572
+ ++ LD L LKA SQVE +L +R ++ L +IE
Sbjct: 2202 TDHQ---KNLLD--EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2256
Query: 573 NL 574
L
Sbjct: 2257 AL 2258
Score = 54.3 bits (129), Expect = 3e-07
Identities = 103/504 (20%), Positives = 186/504 (36%), Gaps = 83/504 (16%)
Query: 131 LEEVQQVR-RSHQDFSRQREELGQGLQ------------GVEQKVQSLQATFGTFESILR 177
+EE +++R R+ Q+ +RQ + + Q V+QK Q LQ T +S+L
Sbjct: 2022 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2081
Query: 178 SSQHKQDLTEKAVKQG-ESEVSRISEVLQ-KLQNEILKDLSDGIHVVKDARERDFTSLEN 235
+ + + +A ++ E+ V E Q + Q E + L AR + + E
Sbjct: 2082 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2141
Query: 236 TVEERLTELTKSINDNIAIFTEVQKRSQKEINDMKAKVASLEESEGNKQDLKALKEAVKE 295
+E E + A + Q + K +L + +Q+L L+ ++E
Sbjct: 2142 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2201
Query: 296 IQTSAKSREWDMEAL----------RSTLQTMESDIYTEVRELVSLKQEQQAFKEA---- 341
+ +++ L RS ++ + ++ EL LK +A A
Sbjct: 2202 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2261
Query: 342 -ADTERLALQALTEKLLRSEESVSRL---PEEIRRL----EEELRQ--------LKSDSH 385
D + LQ EK+ + E +RL +E RL EE+L Q LK
Sbjct: 2262 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2321
Query: 386 GPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQVASARQTESLESLLSKSQEHE 445
+E R E LQQ+ + + + +++ M A +T+ + L ++ +
Sbjct: 2322 AVQE--ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2379
Query: 446 QRLAALQGRLE--------GLGSSEADQDGLASTVRSLGE----TQLVLY---------- 483
++A RL+ +E D +GE T+L
Sbjct: 2380 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2439
Query: 484 -------GDVEELKRSVGELPSTVESLQK-------VQEQVHTLLSQDQAQAARLPPQDF 529
D E L+ ++ EL E LQ+ E++ T+ + Q + Q F
Sbjct: 2440 IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF 2499
Query: 530 LDRLSSLDNLKASVSQVEADLKML 553
L SL + + Q +A L+ L
Sbjct: 2500 LSEKDSLLQRERFIEQEKAKLEQL 2523
Score = 52.0 bits (123), Expect = 2e-06
Identities = 74/337 (21%), Positives = 132/337 (39%), Gaps = 31/337 (9%)
Query: 142 QDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVKQGESEVSRI- 200
Q F +Q EE+G+ L E Q T E + S H + +A+ + E E ++
Sbjct: 2408 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2467
Query: 201 ---------SEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDN 251
SE +Q +Q E L + + + + E +E+ +L + D
Sbjct: 2468 QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2527
Query: 252 IAIFTEVQKRSQKEINDMKAK----VASLEESEGNKQDL-KALKEAVKEIQTSAKSREWD 306
+A ++++ Q++ M+ + VAS+EE+ + + + ++ +E+Q + R
Sbjct: 2528 VAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2587
Query: 307 MEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSRL 366
E L Q +RE + L +EQ A E A Q K L +
Sbjct: 2588 EELLAEENQ--------RLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDG 2639
Query: 367 PEEIRRLEEELRQLKSDSHGPK-EDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQV 425
P E L+ + ++ G +E + L Q +D L ED +Q
Sbjct: 2640 PAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVD-ELARREDVRHYLQG 2698
Query: 426 ASARQTESLESLLSKSQEHEQRL-AALQGRLEGLGSS 461
S S+ LL K+ + + AALQ +L G++
Sbjct: 2699 RS-----SIAGLLLKATNEKLSVYAALQRQLLSPGTA 2730
Score = 45.1 bits (105), Expect = 2e-04
Identities = 79/410 (19%), Positives = 164/410 (40%), Gaps = 55/410 (13%)
Query: 133 EVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQAT-FGTFESILRSSQHKQDLTEKAVK 191
E++Q+ R + + + LG LQ ++ + +QA +++ + +Q L E+ +
Sbjct: 1205 ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIER 1264
Query: 192 QGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDN 251
GE E Q+ + + + D E + + +E + K
Sbjct: 1265 HGEKV-----EECQRFAKQYINAIKD--------YELQLVTYKAQLEPVASPAKKP---- 1307
Query: 252 IAIFTEVQKRSQKEIND-MKAKVASLEESEGNKQDLKALKEAVKEIQTSAKSREWDMEAL 310
+VQ S+ I + + + E + Q +K + E ++ ++ + E
Sbjct: 1308 -----KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE 1362
Query: 311 RSTLQTMESDIYTEVRELVSL--KQEQQAFKEAADTERLALQALTEKLLRSEESVSRLPE 368
R L +E+ + + R+L + + QA +EA + + Q + E+++R EE+ +
Sbjct: 1363 RERLAEVEAALEKQ-RQLAEAHAQAKAQAEREAKELQ----QRMQEEVVRREEAAVDAQQ 1417
Query: 369 EIRRLEEELRQLKSDSHGPKEDGGFRHSEA------------------FEALQQKSQGLD 410
+ R ++EEL+QL+ S + R +EA EA +++ G +
Sbjct: 1418 QKRSIQEELQQLRQSSEA-EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAE 1476
Query: 411 SRLQHVEDGVLSMQVASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLAS 470
LQ + + + E E L + Q+ QR Q +E +A+ +
Sbjct: 1477 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR--KRQAEVELASRVKAEAEAARE 1534
Query: 471 TVRSLGETQLVLYGDVEELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQ 520
R+L + L EE +R + + + VE ++VQ + T +A+
Sbjct: 1535 KQRALQALE-ELRLQAEEAERRLRQ--AEVERARQVQVALETAQRSAEAE 1581
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 68.6 bits (166), Expect = 2e-11
Identities = 115/492 (23%), Positives = 193/492 (39%), Gaps = 68/492 (13%)
Query: 132 EEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVK 191
EE++ VR + RQR G E ++Q+L+A E+ R +Q + + + V
Sbjct: 1452 EEIRVVRLQLEATERQRG-------GAEGELQALRARAEEAEAQKRQAQEEAERLRRQV- 1503
Query: 192 QGESEVSRISEV----LQKLQNEILKDLSDGIHVVKDAR------ERDFTSLE----NTV 237
Q ES+ R +EV K + E ++ + +++ R ER E V
Sbjct: 1504 QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1563
Query: 238 EERLTELTKSINDNI----AIFTEVQKRSQKEINDMKAKVASLEESEGNKQDLKALKEAV 293
+ L +S + A F E + ++ + + VA L E + +A E
Sbjct: 1564 QVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1623
Query: 294 KEIQTSAKSREWDM---EALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQ 350
+E + + W + EALR LQ E + + + KQ+++A +EA + Q
Sbjct: 1624 RE-EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1682
Query: 351 ALTEKLLRSEE-----------SVSRL--PEEIRRLEEELRQLKSDSHGPKEDGGFRHSE 397
A+ ++ L +E + RL +E+ RL E Q + +E+ E
Sbjct: 1683 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1742
Query: 398 AFEALQQKSQGLDSRLQHVEDGVLSMQVASARQTESLESLLSKSQEHEQRLAALQGRLEG 457
A A QK Q L++ L V M+V A + + E S S++ +QRL A GR
Sbjct: 1743 A-AAATQKRQELEAELAKVR---AEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1798
Query: 458 LGSSEADQDGLASTV---RSLGETQLVLYGDVEELKRSVGELPSTVESLQKVQEQVHTLL 514
L A LA R L E E +R + E + + +++ + L
Sbjct: 1799 LAEEAARLRALAEEAKRQRQLAEEDAA--RQRAEAERVLAEKLAAIGEATRLKTEAEIAL 1856
Query: 515 SQDQAQ---AARLPPQDFLDRLSSLDNLKASVSQVEADLKMLRTAVDSLVAYSVKIETNE 571
+ +A+ RL + R + + +E L LR A DS
Sbjct: 1857 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDS------------ 1904
Query: 572 NNLESAKGLLDD 583
LE KGL++D
Sbjct: 1905 -ELERQKGLVED 1915
Score = 56.6 bits (135), Expect = 6e-08
Identities = 109/482 (22%), Positives = 188/482 (39%), Gaps = 67/482 (13%)
Query: 132 EEVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVK 191
EE ++R ++ RQR+ + Q+ ++ + +I +++ K + E A+K
Sbjct: 1801 EEAARLRALAEEAKRQRQLAEE--DAARQRAEAERVLAEKLAAIGEATRLKTE-AEIALK 1857
Query: 192 QGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDN 251
+ E+E NE L+ L++ + E + +EERL +L K+ +
Sbjct: 1858 EKEAE------------NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 1905
Query: 252 I----AIFTEVQKRSQKEINDMKAKVASLEESEGNKQDLK-ALKEAVKEIQTSAKSREW- 305
+ + + ++ ++ ++ A AS E++ K +L+ L + + +S+E
Sbjct: 1906 LERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA 1965
Query: 306 DMEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSR 365
++EA R E + RE Q+ A +E A +R A E+L E R
Sbjct: 1966 ELEAARQRQLAAEEE--RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2023
Query: 366 LPEEIRRLEEELRQLK-SDSHGPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSM- 423
L E R +E RQL+ + K + AF A+QQK Q L LQ E VL
Sbjct: 2024 LRE--RAEQESARQLQLAQEAAQKRLQAEEKAHAF-AVQQKEQELQQTLQQ-EQSVLDQL 2079
Query: 424 ------------------------QVASARQTESLESLLSKSQEHEQRLAALQGRLEGLG 459
S RQ E E L ++E Q A Q E L
Sbjct: 2080 RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL- 2138
Query: 460 SSEADQDGLASTVRSLGETQLVLYGDVEELKRSVGELPSTVESLQKVQEQVHTLLSQDQA 519
EA+Q+ + D E+++ T+ +V++++ TL Q +
Sbjct: 2139 RKEAEQEAARRAQAEQAALRQKQAADA-EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2197
Query: 520 QAARLPPQDFLDRLSSLDNLKASV-------SQVEADLKMLRTAVDSLVAYSVKIETNEN 572
+ ++ LD L LKA SQVE +L +R ++ L +IE
Sbjct: 2198 TDHQ---KNLLD--EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2252
Query: 573 NL 574
L
Sbjct: 2253 AL 2254
Score = 54.3 bits (129), Expect = 3e-07
Identities = 103/504 (20%), Positives = 186/504 (36%), Gaps = 83/504 (16%)
Query: 131 LEEVQQVR-RSHQDFSRQREELGQGLQ------------GVEQKVQSLQATFGTFESILR 177
+EE +++R R+ Q+ +RQ + + Q V+QK Q LQ T +S+L
Sbjct: 2018 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2077
Query: 178 SSQHKQDLTEKAVKQG-ESEVSRISEVLQ-KLQNEILKDLSDGIHVVKDARERDFTSLEN 235
+ + + +A ++ E+ V E Q + Q E + L AR + + E
Sbjct: 2078 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2137
Query: 236 TVEERLTELTKSINDNIAIFTEVQKRSQKEINDMKAKVASLEESEGNKQDLKALKEAVKE 295
+E E + A + Q + K +L + +Q+L L+ ++E
Sbjct: 2138 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2197
Query: 296 IQTSAKSREWDMEAL----------RSTLQTMESDIYTEVRELVSLKQEQQAFKEA---- 341
+ +++ L RS ++ + ++ EL LK +A A
Sbjct: 2198 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2257
Query: 342 -ADTERLALQALTEKLLRSEESVSRL---PEEIRRL----EEELRQ--------LKSDSH 385
D + LQ EK+ + E +RL +E RL EE+L Q LK
Sbjct: 2258 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2317
Query: 386 GPKEDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQVASARQTESLESLLSKSQEHE 445
+E R E LQQ+ + + + +++ M A +T+ + L ++ +
Sbjct: 2318 AVQE--ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2375
Query: 446 QRLAALQGRLE--------GLGSSEADQDGLASTVRSLGE----TQLVLY---------- 483
++A RL+ +E D +GE T+L
Sbjct: 2376 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2435
Query: 484 -------GDVEELKRSVGELPSTVESLQK-------VQEQVHTLLSQDQAQAARLPPQDF 529
D E L+ ++ EL E LQ+ E++ T+ + Q + Q F
Sbjct: 2436 IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSF 2495
Query: 530 LDRLSSLDNLKASVSQVEADLKML 553
L SL + + Q +A L+ L
Sbjct: 2496 LSEKDSLLQRERFIEQEKAKLEQL 2519
Score = 52.0 bits (123), Expect = 2e-06
Identities = 74/337 (21%), Positives = 132/337 (39%), Gaps = 31/337 (9%)
Query: 142 QDFSRQREELGQGLQGVEQKVQSLQATFGTFESILRSSQHKQDLTEKAVKQGESEVSRI- 200
Q F +Q EE+G+ L E Q T E + S H + +A+ + E E ++
Sbjct: 2404 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2463
Query: 201 ---------SEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDN 251
SE +Q +Q E L + + + + E +E+ +L + D
Sbjct: 2464 QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2523
Query: 252 IAIFTEVQKRSQKEINDMKAK----VASLEESEGNKQDL-KALKEAVKEIQTSAKSREWD 306
+A ++++ Q++ M+ + VAS+EE+ + + + ++ +E+Q + R
Sbjct: 2524 VAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2583
Query: 307 MEALRSTLQTMESDIYTEVRELVSLKQEQQAFKEAADTERLALQALTEKLLRSEESVSRL 366
E L Q +RE + L +EQ A E A Q K L +
Sbjct: 2584 EELLAEENQ--------RLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDG 2635
Query: 367 PEEIRRLEEELRQLKSDSHGPK-EDGGFRHSEAFEALQQKSQGLDSRLQHVEDGVLSMQV 425
P E L+ + ++ G +E + L Q +D L ED +Q
Sbjct: 2636 PAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVD-ELARREDVRHYLQG 2694
Query: 426 ASARQTESLESLLSKSQEHEQRL-AALQGRLEGLGSS 461
S S+ LL K+ + + AALQ +L G++
Sbjct: 2695 RS-----SIAGLLLKATNEKLSVYAALQRQLLSPGTA 2726
Score = 45.1 bits (105), Expect = 2e-04
Identities = 79/410 (19%), Positives = 164/410 (40%), Gaps = 55/410 (13%)
Query: 133 EVQQVRRSHQDFSRQREELGQGLQGVEQKVQSLQAT-FGTFESILRSSQHKQDLTEKAVK 191
E++Q+ R + + + LG LQ ++ + +QA +++ + +Q L E+ +
Sbjct: 1201 ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIER 1260
Query: 192 QGESEVSRISEVLQKLQNEILKDLSDGIHVVKDARERDFTSLENTVEERLTELTKSINDN 251
GE E Q+ + + + D E + + +E + K
Sbjct: 1261 HGEKV-----EECQRFAKQYINAIKD--------YELQLVTYKAQLEPVASPAKKP---- 1303
Query: 252 IAIFTEVQKRSQKEIND-MKAKVASLEESEGNKQDLKALKEAVKEIQTSAKSREWDMEAL 310
+VQ S+ I + + + E + Q +K + E ++ ++ + E
Sbjct: 1304 -----KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE 1358
Query: 311 RSTLQTMESDIYTEVRELVSL--KQEQQAFKEAADTERLALQALTEKLLRSEESVSRLPE 368
R L +E+ + + R+L + + QA +EA + + Q + E+++R EE+ +
Sbjct: 1359 RERLAEVEAALEKQ-RQLAEAHAQAKAQAEREAKELQ----QRMQEEVVRREEAAVDAQQ 1413
Query: 369 EIRRLEEELRQLKSDSHGPKEDGGFRHSEA------------------FEALQQKSQGLD 410
+ R ++EEL+QL+ S + R +EA EA +++ G +
Sbjct: 1414 QKRSIQEELQQLRQSSEA-EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAE 1472
Query: 411 SRLQHVEDGVLSMQVASARQTESLESLLSKSQEHEQRLAALQGRLEGLGSSEADQDGLAS 470
LQ + + + E E L + Q+ QR Q +E +A+ +
Sbjct: 1473 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR--KRQAEVELASRVKAEAEAARE 1530
Query: 471 TVRSLGETQLVLYGDVEELKRSVGELPSTVESLQKVQEQVHTLLSQDQAQ 520
R+L + L EE +R + + + VE ++VQ + T +A+
Sbjct: 1531 KQRALQALE-ELRLQAEEAERRLRQ--AEVERARQVQVALETAQRSAEAE 1577
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.308 0.125 0.330
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,765,559
Number of Sequences: 37866
Number of extensions: 1175808
Number of successful extensions: 37950
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 820
Number of HSP's successfully gapped in prelim test: 1527
Number of HSP's that attempted gapping in prelim test: 18643
Number of HSP's gapped (non-prelim): 13116
length of query: 602
length of database: 18,247,518
effective HSP length: 108
effective length of query: 494
effective length of database: 14,157,990
effective search space: 6994047060
effective search space used: 6994047060
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.