Guide to the Human Genome
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Search of human proteins with 197333706

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|197333706 leucine rich repeat containing 8 family, member D
[Homo sapiens]
         (858 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|197333706 leucine rich repeat containing 8 family, member D [...  1725   0.0  
gi|34222199 leucine rich repeat containing 8 family, member D [H...  1725   0.0  
gi|62241040 leucine rich repeat containing 8 family, member A [H...   926   0.0  
gi|187829877 leucine rich repeat containing 8 family, member A [...   926   0.0  
gi|187829871 leucine rich repeat containing 8 family, member A [...   926   0.0  
gi|19923729 leucine rich repeat containing 8 family, member C [H...   858   0.0  
gi|40217803 leucine rich repeat containing 8 family, member E [H...   806   0.0  
gi|197333692 leucine rich repeat containing 8 family, member B [...   769   0.0  
gi|21245134 leucine rich repeat containing 8 family, member B [H...   769   0.0  
gi|95113664 leucine rich repeat containing 1 [Homo sapiens]           120   4e-27
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]          119   9e-27
gi|16904383 leucine rich repeat containing 7 [Homo sapiens]           117   6e-26
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]        110   4e-24
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]         110   4e-24
gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens]          110   7e-24
gi|45827729 scribble isoform b [Homo sapiens]                         110   7e-24
gi|45827731 scribble isoform a [Homo sapiens]                         110   7e-24
gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom...   109   9e-24
gi|4503743 flightless I homolog [Homo sapiens]                        105   1e-22
gi|238908508 leucine-rich repeat and death domain-containing pro...   105   2e-22
gi|110825984 malignant fibrous histiocytoma amplified sequence 1...   103   5e-22
gi|21361633 leucine rich repeat containing 40 [Homo sapiens]          103   5e-22
gi|4504379 leucine-rich repeat-containing G protein-coupled rece...    95   2e-19
gi|34577083 ras suppressor protein 1 isoform 2 [Homo sapiens]          92   2e-18
gi|33285015 leucine rich repeat containing 28 [Homo sapiens]           91   5e-18
gi|21389431 leucine rich repeat containing 39 [Homo sapiens]           91   6e-18
gi|61742786 leucine rich repeat and death domain containing prot...    90   8e-18
gi|61742784 leucine rich repeat and death domain containing prot...    90   8e-18
gi|154091020 leucine-rich repeats and calponin homology (CH) dom...    88   4e-17
gi|30181233 leucine-rich repeats and calponin homology (CH) doma...    88   4e-17

>gi|197333706 leucine rich repeat containing 8 family, member D
           [Homo sapiens]
          Length = 858

 Score = 1725 bits (4468), Expect = 0.0
 Identities = 858/858 (100%), Positives = 858/858 (100%)

Query: 1   MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPS 60
           MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPS
Sbjct: 1   MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPS 60

Query: 61  PVNSKAHTPPGNAEVTTNIPKMEAATNQDQDGRTTNDISFGTSAVTPDIPLRATYPRTDF 120
           PVNSKAHTPPGNAEVTTNIPKMEAATNQDQDGRTTNDISFGTSAVTPDIPLRATYPRTDF
Sbjct: 61  PVNSKAHTPPGNAEVTTNIPKMEAATNQDQDGRTTNDISFGTSAVTPDIPLRATYPRTDF 120

Query: 121 ALPNQEAKKEKKDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSS 180
           ALPNQEAKKEKKDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSS
Sbjct: 121 ALPNQEAKKEKKDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSS 180

Query: 181 NFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVST 240
           NFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVST
Sbjct: 181 NFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVST 240

Query: 241 SSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVED 300
           SSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVED
Sbjct: 241 SSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVED 300

Query: 301 SDLIYKLYVVQTVIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMAY 360
           SDLIYKLYVVQTVIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMAY
Sbjct: 301 SDLIYKLYVVQTVIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMAY 360

Query: 361 MLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLL 420
           MLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLL
Sbjct: 361 MLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLL 420

Query: 421 HMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLS 480
           HMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLS
Sbjct: 421 HMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLS 480

Query: 481 GVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLR 540
           GVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLR
Sbjct: 481 GVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLR 540

Query: 541 CLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLT 600
           CLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLT
Sbjct: 541 CLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLT 600

Query: 601 KVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNL 660
           KVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNL
Sbjct: 601 KVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNL 660

Query: 661 QELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLES 720
           QELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLES
Sbjct: 661 QELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLES 720

Query: 721 LPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTL 780
           LPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTL
Sbjct: 721 LPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTL 780

Query: 781 NLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPL 840
           NLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPL
Sbjct: 781 NLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPL 840

Query: 841 EVKEALNQDINIPFANGI 858
           EVKEALNQDINIPFANGI
Sbjct: 841 EVKEALNQDINIPFANGI 858


>gi|34222199 leucine rich repeat containing 8 family, member D [Homo
           sapiens]
          Length = 858

 Score = 1725 bits (4468), Expect = 0.0
 Identities = 858/858 (100%), Positives = 858/858 (100%)

Query: 1   MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPS 60
           MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPS
Sbjct: 1   MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPS 60

Query: 61  PVNSKAHTPPGNAEVTTNIPKMEAATNQDQDGRTTNDISFGTSAVTPDIPLRATYPRTDF 120
           PVNSKAHTPPGNAEVTTNIPKMEAATNQDQDGRTTNDISFGTSAVTPDIPLRATYPRTDF
Sbjct: 61  PVNSKAHTPPGNAEVTTNIPKMEAATNQDQDGRTTNDISFGTSAVTPDIPLRATYPRTDF 120

Query: 121 ALPNQEAKKEKKDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSS 180
           ALPNQEAKKEKKDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSS
Sbjct: 121 ALPNQEAKKEKKDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSS 180

Query: 181 NFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVST 240
           NFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVST
Sbjct: 181 NFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVST 240

Query: 241 SSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVED 300
           SSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVED
Sbjct: 241 SSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVED 300

Query: 301 SDLIYKLYVVQTVIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMAY 360
           SDLIYKLYVVQTVIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMAY
Sbjct: 301 SDLIYKLYVVQTVIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMAY 360

Query: 361 MLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLL 420
           MLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLL
Sbjct: 361 MLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLL 420

Query: 421 HMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLS 480
           HMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLS
Sbjct: 421 HMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLS 480

Query: 481 GVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLR 540
           GVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLR
Sbjct: 481 GVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLR 540

Query: 541 CLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLT 600
           CLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLT
Sbjct: 541 CLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLT 600

Query: 601 KVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNL 660
           KVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNL
Sbjct: 601 KVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNL 660

Query: 661 QELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLES 720
           QELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLES
Sbjct: 661 QELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLES 720

Query: 721 LPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTL 780
           LPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTL
Sbjct: 721 LPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTL 780

Query: 781 NLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPL 840
           NLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPL
Sbjct: 781 NLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPL 840

Query: 841 EVKEALNQDINIPFANGI 858
           EVKEALNQDINIPFANGI
Sbjct: 841 EVKEALNQDINIPFANGI 858


>gi|62241040 leucine rich repeat containing 8 family, member A [Homo
           sapiens]
          Length = 810

 Score =  926 bits (2392), Expect = 0.0
 Identities = 460/846 (54%), Positives = 612/846 (72%), Gaps = 44/846 (5%)

Query: 1   MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPS 60
           M  + E+    D QP YRILKPWWDVF DY+++VMLM+A+F GT+Q+T+D+++CLP    
Sbjct: 1   MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPC--- 57

Query: 61  PVNSKAHTPPGNAEVTTNIPKMEAATNQDQDGRTTNDISFGTSAVTPDIPLRATYPRTDF 120
                         VT +               + ND   G +A  P+     TYP +  
Sbjct: 58  ------------KWVTKD---------------SCNDSFRGWAAPGPE----PTYPNSTI 86

Query: 121 ALPNQEAKKEKKDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSS 180
            LP  +       PTG K +LD  QY +++ +CY   L W++KYFPYL L+HT+I +  S
Sbjct: 87  -LPTPDT-----GPTGIKYDLDRHQYNYVDAVCYENRLHWFAKYFPYLVLLHTLIFLACS 140

Query: 181 NFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVST 240
           NFWFK+P+T SK+EHFVSIL KCF+SPWTT+ALSET  E+S+          ++ K  ST
Sbjct: 141 NFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSETVVEESDPKPAFSKMNGSMDKKSST 200

Query: 241 SSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVED 300
            S++    A+ PM+ +T  K   E+ +++     +LDKK+GEQAKALFEKV+KFR HVE+
Sbjct: 201 VSED--VEATVPMLQRT--KSRIEQGIVDRSETGVLDKKEGEQAKALFEKVKKFRTHVEE 256

Query: 301 SDLIYKLYVVQTVIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMAY 360
            D++Y+LY+ QT+IK  KFI I+CYT  +V+ I F+  C   +E L GY  + C H +A 
Sbjct: 257 GDIVYRLYMRQTIIKVIKFILIICYTVYYVHNIKFDVDCTVDIESLTGYRTYRCAHPLAT 316

Query: 361 MLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLL 420
           + K L   YIS++  YG IC+YTL+W+ R  LK+YSFE +REESS+SDIPDVKNDFAF+L
Sbjct: 317 LFKILASFYISLVIFYGLICMYTLWWMLRRSLKKYSFESIREESSYSDIPDVKNDFAFML 376

Query: 421 HMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLS 480
           H++DQYD LYSKRF VFLSEVSENKLR+++LN+EWT +KLRQ +++NAQDK ELHLFMLS
Sbjct: 377 HLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQRLTKNAQDKLELHLFMLS 436

Query: 481 GVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLR 540
           G+PD VFDL +L+VLKLELIP+  IP  I+Q+T L+EL L H  AK+E  A +FLR++LR
Sbjct: 437 GIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLR 496

Query: 541 CLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLT 600
            LH+KFTD+ EIP W+Y LK L EL+L GNL++ENN+ I ++ LREL+ LK+L +KSNL+
Sbjct: 497 ALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLS 556

Query: 601 KVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNL 660
           K+P  +TDV  HL KL I+N+GTKL+VLNSLKKM N+ ELEL  C+LERIPH+IFSL NL
Sbjct: 557 KLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNL 616

Query: 661 QELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLES 720
           QE+DLK NN++TIEEIISFQHL RLTCLKLW+N I  IP  I ++ NLE LY + NK+E 
Sbjct: 617 QEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEK 676

Query: 721 LPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTL 780
           +P  +F  +KLR LD+S+NN++ +P +IGLLQNLQ+L IT N+++ LP +LF+C KLR L
Sbjct: 677 IPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRAL 736

Query: 781 NLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPL 840
           +LG N + SLP +VG+L+ LTQ+EL+GN L+ LP +LG+C +LK+SGLVVE+ LF+TLP 
Sbjct: 737 HLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPP 796

Query: 841 EVKEAL 846
           EVKE L
Sbjct: 797 EVKERL 802


>gi|187829877 leucine rich repeat containing 8 family, member A
           [Homo sapiens]
          Length = 810

 Score =  926 bits (2392), Expect = 0.0
 Identities = 460/846 (54%), Positives = 612/846 (72%), Gaps = 44/846 (5%)

Query: 1   MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPS 60
           M  + E+    D QP YRILKPWWDVF DY+++VMLM+A+F GT+Q+T+D+++CLP    
Sbjct: 1   MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPC--- 57

Query: 61  PVNSKAHTPPGNAEVTTNIPKMEAATNQDQDGRTTNDISFGTSAVTPDIPLRATYPRTDF 120
                         VT +               + ND   G +A  P+     TYP +  
Sbjct: 58  ------------KWVTKD---------------SCNDSFRGWAAPGPE----PTYPNSTI 86

Query: 121 ALPNQEAKKEKKDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSS 180
            LP  +       PTG K +LD  QY +++ +CY   L W++KYFPYL L+HT+I +  S
Sbjct: 87  -LPTPDT-----GPTGIKYDLDRHQYNYVDAVCYENRLHWFAKYFPYLVLLHTLIFLACS 140

Query: 181 NFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVST 240
           NFWFK+P+T SK+EHFVSIL KCF+SPWTT+ALSET  E+S+          ++ K  ST
Sbjct: 141 NFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSETVVEESDPKPAFSKMNGSMDKKSST 200

Query: 241 SSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVED 300
            S++    A+ PM+ +T  K   E+ +++     +LDKK+GEQAKALFEKV+KFR HVE+
Sbjct: 201 VSED--VEATVPMLQRT--KSRIEQGIVDRSETGVLDKKEGEQAKALFEKVKKFRTHVEE 256

Query: 301 SDLIYKLYVVQTVIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMAY 360
            D++Y+LY+ QT+IK  KFI I+CYT  +V+ I F+  C   +E L GY  + C H +A 
Sbjct: 257 GDIVYRLYMRQTIIKVIKFILIICYTVYYVHNIKFDVDCTVDIESLTGYRTYRCAHPLAT 316

Query: 361 MLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLL 420
           + K L   YIS++  YG IC+YTL+W+ R  LK+YSFE +REESS+SDIPDVKNDFAF+L
Sbjct: 317 LFKILASFYISLVIFYGLICMYTLWWMLRRSLKKYSFESIREESSYSDIPDVKNDFAFML 376

Query: 421 HMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLS 480
           H++DQYD LYSKRF VFLSEVSENKLR+++LN+EWT +KLRQ +++NAQDK ELHLFMLS
Sbjct: 377 HLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQRLTKNAQDKLELHLFMLS 436

Query: 481 GVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLR 540
           G+PD VFDL +L+VLKLELIP+  IP  I+Q+T L+EL L H  AK+E  A +FLR++LR
Sbjct: 437 GIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLR 496

Query: 541 CLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLT 600
            LH+KFTD+ EIP W+Y LK L EL+L GNL++ENN+ I ++ LREL+ LK+L +KSNL+
Sbjct: 497 ALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLS 556

Query: 601 KVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNL 660
           K+P  +TDV  HL KL I+N+GTKL+VLNSLKKM N+ ELEL  C+LERIPH+IFSL NL
Sbjct: 557 KLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNL 616

Query: 661 QELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLES 720
           QE+DLK NN++TIEEIISFQHL RLTCLKLW+N I  IP  I ++ NLE LY + NK+E 
Sbjct: 617 QEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEK 676

Query: 721 LPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTL 780
           +P  +F  +KLR LD+S+NN++ +P +IGLLQNLQ+L IT N+++ LP +LF+C KLR L
Sbjct: 677 IPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRAL 736

Query: 781 NLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPL 840
           +LG N + SLP +VG+L+ LTQ+EL+GN L+ LP +LG+C +LK+SGLVVE+ LF+TLP 
Sbjct: 737 HLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPP 796

Query: 841 EVKEAL 846
           EVKE L
Sbjct: 797 EVKERL 802


>gi|187829871 leucine rich repeat containing 8 family, member A
           [Homo sapiens]
          Length = 810

 Score =  926 bits (2392), Expect = 0.0
 Identities = 460/846 (54%), Positives = 612/846 (72%), Gaps = 44/846 (5%)

Query: 1   MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPS 60
           M  + E+    D QP YRILKPWWDVF DY+++VMLM+A+F GT+Q+T+D+++CLP    
Sbjct: 1   MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPC--- 57

Query: 61  PVNSKAHTPPGNAEVTTNIPKMEAATNQDQDGRTTNDISFGTSAVTPDIPLRATYPRTDF 120
                         VT +               + ND   G +A  P+     TYP +  
Sbjct: 58  ------------KWVTKD---------------SCNDSFRGWAAPGPE----PTYPNSTI 86

Query: 121 ALPNQEAKKEKKDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSS 180
            LP  +       PTG K +LD  QY +++ +CY   L W++KYFPYL L+HT+I +  S
Sbjct: 87  -LPTPDT-----GPTGIKYDLDRHQYNYVDAVCYENRLHWFAKYFPYLVLLHTLIFLACS 140

Query: 181 NFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVST 240
           NFWFK+P+T SK+EHFVSIL KCF+SPWTT+ALSET  E+S+          ++ K  ST
Sbjct: 141 NFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSETVVEESDPKPAFSKMNGSMDKKSST 200

Query: 241 SSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVED 300
            S++    A+ PM+ +T  K   E+ +++     +LDKK+GEQAKALFEKV+KFR HVE+
Sbjct: 201 VSED--VEATVPMLQRT--KSRIEQGIVDRSETGVLDKKEGEQAKALFEKVKKFRTHVEE 256

Query: 301 SDLIYKLYVVQTVIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMAY 360
            D++Y+LY+ QT+IK  KFI I+CYT  +V+ I F+  C   +E L GY  + C H +A 
Sbjct: 257 GDIVYRLYMRQTIIKVIKFILIICYTVYYVHNIKFDVDCTVDIESLTGYRTYRCAHPLAT 316

Query: 361 MLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLL 420
           + K L   YIS++  YG IC+YTL+W+ R  LK+YSFE +REESS+SDIPDVKNDFAF+L
Sbjct: 317 LFKILASFYISLVIFYGLICMYTLWWMLRRSLKKYSFESIREESSYSDIPDVKNDFAFML 376

Query: 421 HMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLS 480
           H++DQYD LYSKRF VFLSEVSENKLR+++LN+EWT +KLRQ +++NAQDK ELHLFMLS
Sbjct: 377 HLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQRLTKNAQDKLELHLFMLS 436

Query: 481 GVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLR 540
           G+PD VFDL +L+VLKLELIP+  IP  I+Q+T L+EL L H  AK+E  A +FLR++LR
Sbjct: 437 GIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLR 496

Query: 541 CLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLT 600
            LH+KFTD+ EIP W+Y LK L EL+L GNL++ENN+ I ++ LREL+ LK+L +KSNL+
Sbjct: 497 ALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLS 556

Query: 601 KVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNL 660
           K+P  +TDV  HL KL I+N+GTKL+VLNSLKKM N+ ELEL  C+LERIPH+IFSL NL
Sbjct: 557 KLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNL 616

Query: 661 QELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLES 720
           QE+DLK NN++TIEEIISFQHL RLTCLKLW+N I  IP  I ++ NLE LY + NK+E 
Sbjct: 617 QEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEK 676

Query: 721 LPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTL 780
           +P  +F  +KLR LD+S+NN++ +P +IGLLQNLQ+L IT N+++ LP +LF+C KLR L
Sbjct: 677 IPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRAL 736

Query: 781 NLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPL 840
           +LG N + SLP +VG+L+ LTQ+EL+GN L+ LP +LG+C +LK+SGLVVE+ LF+TLP 
Sbjct: 737 HLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPP 796

Query: 841 EVKEAL 846
           EVKE L
Sbjct: 797 EVKERL 802


>gi|19923729 leucine rich repeat containing 8 family, member C [Homo
           sapiens]
          Length = 803

 Score =  858 bits (2216), Expect = 0.0
 Identities = 428/849 (50%), Positives = 582/849 (68%), Gaps = 46/849 (5%)

Query: 1   MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPS 60
           M  + E    ++ QP +R+LKPWWDVF DYL+V MLM+ +F  T+Q+ +D+++CLP    
Sbjct: 1   MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIICLPKRVQ 60

Query: 61  PVNSKAHTPPGNAEVTTNIPKMEAATNQDQDGRTTNDISFGTSAVTPDIPLRATYPRTDF 120
           P                            Q+  + +++S   ++ TP  P     P+   
Sbjct: 61  PA---------------------------QNHSSLSNVSQAVASTTPLPP-----PKPSP 88

Query: 121 ALPNQEAKKEKKDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSS 180
           A P     K      G KT+LD QQY FINQMCY  AL WY+KYFPYL LIHT++ M+ S
Sbjct: 89  ANPITVEMK------GLKTDLDLQQYSFINQMCYERALHWYAKYFPYLVLIHTLVFMLCS 142

Query: 181 NFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVST 240
           NFWFK+P + SK+EHF+SILGKCF+SPWTT+ALSE + EDSEE   R         +   
Sbjct: 143 NFWFKFPGSSSKIEHFISILGKCFDSPWTTRALSEVSGEDSEEKDNRKNNMNR--SNTIQ 200

Query: 241 SSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVED 300
           S  EGS      ++N    K   EK V++  +   LDKK+GEQAKALFEKV+KFR HVE+
Sbjct: 201 SGPEGS------LVNSQSLKSIPEKFVVDKSTAGALDKKEGEQAKALFEKVKKFRLHVEE 254

Query: 301 SDLIYKLYVVQTVIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMAY 360
            D++Y +YV QTV+K  KF+ I+ Y +  V+ + F   C   ++ + GY+ F C H MA+
Sbjct: 255 GDILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVDCNVDIQDMTGYKNFSCNHTMAH 314

Query: 361 MLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLL 420
           +  KL   Y+  + +YG  CLYTL+WLF   L+EYSFE VR+E+   DIPDVKNDFAF+L
Sbjct: 315 LFSKLSFCYLCFVSIYGLTCLYTLYWLFYRSLREYSFEYVRQETGIDDIPDVKNDFAFML 374

Query: 421 HMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLS 480
           HM+DQYD LYSKRF VFLSEVSENKL++++LN+EWT +KLRQ +  NA ++ EL L MLS
Sbjct: 375 HMIDQYDPLYSKRFAVFLSEVSENKLKQLNLNNEWTPDKLRQKLQTNAHNRLELPLIMLS 434

Query: 481 GVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLR 540
           G+PD VF++T+L  LKLE+I    IPA I+Q+ NLQEL L  C  K+   A SFL+++L+
Sbjct: 435 GLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKENLK 494

Query: 541 CLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLT 600
            L VKF D+ E+P W+Y L+NL ELYL+G+L+ + ++ + LESLR+L+ LKIL +KSN++
Sbjct: 495 VLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRDLKSLKILSIKSNVS 554

Query: 601 KVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNL 660
           K+P  + DV+ HL K+ IHNDGTKL++LN+LKKM N+ ELEL +C+LERIPHA+FSL +L
Sbjct: 555 KIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSLLSL 614

Query: 661 QELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLES 720
           QELDLK NN+++IEEI+SFQHL++LT LKLWHN I  IP  I  + +LE L FS+NK+E 
Sbjct: 615 QELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEV 674

Query: 721 LPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTL 780
           LP  +F   K+R LD+SYN+I  IP EIG+LQ+LQ+  IT NKV+ LP +L+ C KL+TL
Sbjct: 675 LPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTL 734

Query: 781 NLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPL 840
            +G+N ++ L  K+G L  L+ L++KGN  + LP +LG CR LK++GLVVED LF+TLP 
Sbjct: 735 KIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALKRAGLVVEDALFETLPS 794

Query: 841 EVKEALNQD 849
           +V+E +  +
Sbjct: 795 DVREQMKTE 803


>gi|40217803 leucine rich repeat containing 8 family, member E [Homo
           sapiens]
          Length = 796

 Score =  806 bits (2082), Expect = 0.0
 Identities = 411/850 (48%), Positives = 559/850 (65%), Gaps = 55/850 (6%)

Query: 1   MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPS 60
           M  +AE     + QP +++LKPWWDV  +YL V MLM+ +F  T+Q+T+D+++CLP    
Sbjct: 1   MIPVAEFKQFTEQQPAFKVLKPWWDVLAEYLTVAMLMIGVFGCTLQVTQDKIICLP---- 56

Query: 61  PVNSKAHTPPGNAEVTTNIPKMEAATNQDQDGRTTNDISFGTSAVTPDIPLRATYPRTDF 120
                      N E+  N+                            + P +   PR   
Sbjct: 57  -----------NHELQENLS---------------------------EAPCQQLLPR--- 75

Query: 121 ALPNQ-EAKKEKKDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVS 179
            +P Q  A +E K   G K NLD QQY FINQ+CY  AL WY+KYFPYL +IHT+I MV 
Sbjct: 76  GIPEQIGALQEVK---GLKNNLDLQQYSFINQLCYETALHWYAKYFPYLVVIHTLIFMVC 132

Query: 180 SNFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVS 239
           ++FWFK+P T SK+EHF+SILGKCF+SPWTT+ALSE + E+ +        A T+     
Sbjct: 133 TSFWFKFPGTSSKIEHFISILGKCFDSPWTTRALSEVSGENQKGPAATERAAATIVAMAG 192

Query: 240 TSSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVE 299
           T   +        ++ +       EK V E P +T+LDKK+GEQAKALFEKV+KFR HVE
Sbjct: 193 TGPGKAGEGEKEKVLAEP------EKVVTEPPVVTLLDKKEGEQAKALFEKVKKFRMHVE 246

Query: 300 DSDLIYKLYVVQTVIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMA 359
           + D++Y +Y+ QTV+K  KF+ IL Y   +V  ISF   C+ +   + GY  F C H  A
Sbjct: 247 EGDILYTMYIRQTVLKVCKFLAILVYNLVYVEKISFLVACRVETSEVTGYASFCCNHTKA 306

Query: 360 YMLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFL 419
           ++  KL   YIS +C+YG  C+YTL+WLF  PLKEYSF  VREE+   DIPDVKNDFAF+
Sbjct: 307 HLFSKLAFCYISFVCIYGLTCIYTLYWLFHRPLKEYSFRSVREETGMGDIPDVKNDFAFM 366

Query: 420 LHMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFML 479
           LH++DQYD LYSKRF VFLSEVSE++L++++LNHEWT EKLRQ + RNA  + EL L ML
Sbjct: 367 LHLIDQYDSLYSKRFAVFLSEVSESRLKQLNLNHEWTPEKLRQKLQRNAAGRLELALCML 426

Query: 480 SGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHL 539
            G+PD VF+L++++ L+LE I +   P  +SQ+ +LQEL L H PA++  +   FLRDHL
Sbjct: 427 PGLPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLLHSPARLPFSLQVFLRDHL 486

Query: 540 RCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNL 599
           + + VK  ++ E+P WV+ L+ L EL+L G    E  +   LESLREL+ LK+L ++SN 
Sbjct: 487 KVMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATLESLRELKQLKVLSLRSNA 546

Query: 600 TKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSN 659
            KVP+++TDVA HL +L +HNDG +L+ LNSLKK+  + ELEL  C LERIPHA+FSL  
Sbjct: 547 GKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVACGLERIPHAVFSLGA 606

Query: 660 LQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLE 719
           LQELDLK N++R+IEEI+SFQH ++L  L+LWHN+I  +P  +  +++LE LY S NKLE
Sbjct: 607 LQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLE 666

Query: 720 SLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRT 779
           +LP  +     LR LDVS+N +  +P E+GLLQNLQHL ++ N ++ LP++LF C KLRT
Sbjct: 667 TLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRT 726

Query: 780 LNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLP 839
           L LG N ++ L   VG L  L++LELKGN L+ LP +LG C  LKK+GL+VED L+  LP
Sbjct: 727 LLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGLKKAGLLVEDTLYQGLP 786

Query: 840 LEVKEALNQD 849
            EV++ + ++
Sbjct: 787 AEVRDKMEEE 796


>gi|197333692 leucine rich repeat containing 8 family, member B
           [Homo sapiens]
          Length = 803

 Score =  769 bits (1986), Expect = 0.0
 Identities = 393/846 (46%), Positives = 561/846 (66%), Gaps = 50/846 (5%)

Query: 1   MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPS 60
           M TL E+  L D Q +Y ILKPWWDVF  Y+ ++ML+VA+ AG +QLT+ +V+C   LP 
Sbjct: 1   MITLTELKCLADAQSSYHILKPWWDVFWYYITLIMLLVAVLAGALQLTQSRVLCC--LPC 58

Query: 61  PVNSKAHTPPGNAEVTTNIPKMEAATNQDQDGRTTNDISFGTSAVTPDIPLRATYPRTDF 120
            V    H       V  +I K    T+ +                          P T  
Sbjct: 59  KVEFDNH-----CAVPWDILKASMNTSSN--------------------------PGTPL 87

Query: 121 ALPNQEAKKEKKDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSS 180
            LP +            + +L  QQY +I+ +CY   L W++K+FPYL L+HT+I    S
Sbjct: 88  PLPLRI-----------QNDLHRQQYSYIDAVCYEKQLHWFAKFFPYLVLLHTLIFAACS 136

Query: 181 NFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVST 240
           NFW  YP T S++EHFV+IL KCF+SPWTT+ALSET  E S     +++ ++ L      
Sbjct: 137 NFWLHYPSTSSRLEHFVAILHKCFDSPWTTRALSETVAEQSVR-PLKLSKSKILLSSSGC 195

Query: 241 SSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVED 300
           S+D  S   S P           E   IE P+ ++LDKK+GEQAKA+FEKV++FR HVE 
Sbjct: 196 SADIDSGKQSLPYPQP-----GLESAGIESPTSSVLDKKEGEQAKAIFEKVKRFRMHVEQ 250

Query: 301 SDLIYKLYVVQTVIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMAY 360
            D+IY++Y+ Q ++K   F+ I+ Y   F+  I+ E  C   V+   GY+ ++C +++A 
Sbjct: 251 KDIIYRVYLKQIIVKVILFVLIITYVPYFLTHITLEIDCSVDVQAFTGYKRYQCVYSLAE 310

Query: 361 MLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLL 420
           + K L   Y+ ++ +YG    Y+L+W+ R  LK+YSFE +RE+S++SDIPDVKNDFAF+L
Sbjct: 311 IFKVLASFYVILVILYGLTSSYSLWWMLRSSLKQYSFEALREKSNYSDIPDVKNDFAFIL 370

Query: 421 HMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLS 480
           H+ DQYD LYSKRF +FLSEVSENKL++I+LN+EWT EKL+  + +NAQDK ELHLFML+
Sbjct: 371 HLADQYDPLYSKRFSIFLSEVSENKLKQINLNNEWTVEKLKSKLVKNAQDKIELHLFMLN 430

Query: 481 GVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLR 540
           G+PD VF+LT+++VL LELIPE K+P+ +SQ+ NL+EL + H    V+  A +FL ++L+
Sbjct: 431 GLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLK 490

Query: 541 CLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLT 600
            L +KFT++ +IP WV+ LKNL+ELYL G +  E    + LE  ++L++L+ L++KS+L+
Sbjct: 491 ILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSLS 550

Query: 601 KVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNL 660
           ++P  +TD+ P L KL + N+G+KL+VLN+LKKM+N+  LEL +C+LERIPH+IFSL+NL
Sbjct: 551 RIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNL 610

Query: 661 QELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLES 720
            ELDL+ NN++T+EEIISFQHL+ L+CLKLWHN I  IP  I  + NLE L   +N +E+
Sbjct: 611 HELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIEN 670

Query: 721 LPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTL 780
           LP+ +F   KL  LD+SYN+++ IP EI  L NLQ+  +T N +++LP  LF+C KL+ L
Sbjct: 671 LPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCL 730

Query: 781 NLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPL 840
            LG+N + +L   VG+LS LT LEL GN L+ LP +L  C+ LK++ L+VE++L +TLPL
Sbjct: 731 LLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTLPL 790

Query: 841 EVKEAL 846
            V E L
Sbjct: 791 PVTERL 796


>gi|21245134 leucine rich repeat containing 8 family, member B [Homo
           sapiens]
          Length = 803

 Score =  769 bits (1986), Expect = 0.0
 Identities = 393/846 (46%), Positives = 561/846 (66%), Gaps = 50/846 (5%)

Query: 1   MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPS 60
           M TL E+  L D Q +Y ILKPWWDVF  Y+ ++ML+VA+ AG +QLT+ +V+C   LP 
Sbjct: 1   MITLTELKCLADAQSSYHILKPWWDVFWYYITLIMLLVAVLAGALQLTQSRVLCC--LPC 58

Query: 61  PVNSKAHTPPGNAEVTTNIPKMEAATNQDQDGRTTNDISFGTSAVTPDIPLRATYPRTDF 120
            V    H       V  +I K    T+ +                          P T  
Sbjct: 59  KVEFDNH-----CAVPWDILKASMNTSSN--------------------------PGTPL 87

Query: 121 ALPNQEAKKEKKDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSS 180
            LP +            + +L  QQY +I+ +CY   L W++K+FPYL L+HT+I    S
Sbjct: 88  PLPLRI-----------QNDLHRQQYSYIDAVCYEKQLHWFAKFFPYLVLLHTLIFAACS 136

Query: 181 NFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVST 240
           NFW  YP T S++EHFV+IL KCF+SPWTT+ALSET  E S     +++ ++ L      
Sbjct: 137 NFWLHYPSTSSRLEHFVAILHKCFDSPWTTRALSETVAEQSVR-PLKLSKSKILLSSSGC 195

Query: 241 SSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVED 300
           S+D  S   S P           E   IE P+ ++LDKK+GEQAKA+FEKV++FR HVE 
Sbjct: 196 SADIDSGKQSLPYPQP-----GLESAGIESPTSSVLDKKEGEQAKAIFEKVKRFRMHVEQ 250

Query: 301 SDLIYKLYVVQTVIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMAY 360
            D+IY++Y+ Q ++K   F+ I+ Y   F+  I+ E  C   V+   GY+ ++C +++A 
Sbjct: 251 KDIIYRVYLKQIIVKVILFVLIITYVPYFLTHITLEIDCSVDVQAFTGYKRYQCVYSLAE 310

Query: 361 MLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLL 420
           + K L   Y+ ++ +YG    Y+L+W+ R  LK+YSFE +RE+S++SDIPDVKNDFAF+L
Sbjct: 311 IFKVLASFYVILVILYGLTSSYSLWWMLRSSLKQYSFEALREKSNYSDIPDVKNDFAFIL 370

Query: 421 HMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLS 480
           H+ DQYD LYSKRF +FLSEVSENKL++I+LN+EWT EKL+  + +NAQDK ELHLFML+
Sbjct: 371 HLADQYDPLYSKRFSIFLSEVSENKLKQINLNNEWTVEKLKSKLVKNAQDKIELHLFMLN 430

Query: 481 GVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLR 540
           G+PD VF+LT+++VL LELIPE K+P+ +SQ+ NL+EL + H    V+  A +FL ++L+
Sbjct: 431 GLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLK 490

Query: 541 CLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLT 600
            L +KFT++ +IP WV+ LKNL+ELYL G +  E    + LE  ++L++L+ L++KS+L+
Sbjct: 491 ILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSLS 550

Query: 601 KVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNL 660
           ++P  +TD+ P L KL + N+G+KL+VLN+LKKM+N+  LEL +C+LERIPH+IFSL+NL
Sbjct: 551 RIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNL 610

Query: 661 QELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLES 720
            ELDL+ NN++T+EEIISFQHL+ L+CLKLWHN I  IP  I  + NLE L   +N +E+
Sbjct: 611 HELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIEN 670

Query: 721 LPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTL 780
           LP+ +F   KL  LD+SYN+++ IP EI  L NLQ+  +T N +++LP  LF+C KL+ L
Sbjct: 671 LPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCL 730

Query: 781 NLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPL 840
            LG+N + +L   VG+LS LT LEL GN L+ LP +L  C+ LK++ L+VE++L +TLPL
Sbjct: 731 LLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTLPL 790

Query: 841 EVKEAL 846
            V E L
Sbjct: 791 PVTERL 796


>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
          Length = 524

 Score =  120 bits (302), Expect = 4e-27
 Identities = 99/345 (28%), Positives = 176/345 (51%), Gaps = 14/345 (4%)

Query: 482 VPDAVFDLT-DLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPA-KVEQTAFSFLRDHL 539
           VP+ ++     L+ L L+     ++P +  Q+  L++L L      ++     +F++  L
Sbjct: 27  VPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQ--L 84

Query: 540 RCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKS-N 598
             L V   ++ EIP  +   K L+     GN  +        ES  EL++L  L V   +
Sbjct: 85  VELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLP-----ESFPELQNLTCLSVNDIS 139

Query: 599 LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLS 658
           L  +P NI ++  +L  L +  +    L  +SL ++  + EL+L N E+  +P +I +L 
Sbjct: 140 LQSLPENIGNLY-NLASLELRENLLTYLP-DSLTQLRRLEELDLGNNEIYNLPESIGALL 197

Query: 659 NLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKL 718
           +L++L L  N +  + + I   +LK L CL +  N++  +P  I+ + +L  L  S N L
Sbjct: 198 HLKDLWLDGNQLSELPQEIG--NLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLL 255

Query: 719 ESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLR 778
           E++P  +  L+KL  L V  N ++ +P  +G  ++L  L +T N++  LPK + K  KL 
Sbjct: 256 ETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLS 315

Query: 779 TLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRML 823
            LN  +N + SLP+++G    LT   ++ N L R+PA++ Q   L
Sbjct: 316 NLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATEL 360



 Score =  115 bits (287), Expect = 2e-25
 Identities = 97/323 (30%), Positives = 157/323 (48%), Gaps = 14/323 (4%)

Query: 522 HCP-AKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIG 580
           HC    V +  + + R  L  L +    + E+P   + L  LR+L L     S+N     
Sbjct: 21  HCSLVYVPEEIYRYARS-LEELLLDANQLRELPEQFFQLVKLRKLGL-----SDNEIQRL 74

Query: 581 LESLRELRHLKILHVKSN-LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAE 639
              +     L  L V  N + ++P +I+            N  T+L    S  ++ N+  
Sbjct: 75  PPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLP--ESFPELQNLTC 132

Query: 640 LELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIP 699
           L + +  L+ +P  I +L NL  L+L+ N +  + +  S   L+RL  L L +N+I  +P
Sbjct: 133 LSVNDISLQSLPENIGNLYNLASLELRENLLTYLPD--SLTQLRRLEELDLGNNEIYNLP 190

Query: 700 PSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHI 759
            SI  + +L+ L+   N+L  LP  + +L+ L CLDVS N +  +P EI  L +L  L I
Sbjct: 191 ESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVI 250

Query: 760 TGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQ 819
           + N ++ +P  + K  KL  L + QN +T LPE VG+   LT+L L  N L  LP  +G 
Sbjct: 251 SQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIG- 309

Query: 820 CRMLKKSGLVVEDHLFDTLPLEV 842
            ++ K S L  + +   +LP E+
Sbjct: 310 -KLKKLSNLNADRNKLVSLPKEI 331



 Score =  107 bits (266), Expect = 6e-23
 Identities = 107/363 (29%), Positives = 170/363 (46%), Gaps = 21/363 (5%)

Query: 462 QHISRNAQDKQELHLF--MLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELH 519
           + I R A+  +EL L    L  +P+  F L  L  L L      ++P +I+    L EL 
Sbjct: 29  EEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELD 88

Query: 520 LCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMI 579
           +          + SF      C  ++  D +  P    L ++  EL    NL   +   I
Sbjct: 89  VSRNEIPEIPESISF------CKALQVADFSGNPL-TRLPESFPELQ---NLTCLSVNDI 138

Query: 580 GLESLRE----LRHLKILHVKSNL-TKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKM 634
            L+SL E    L +L  L ++ NL T +P ++T +   L +L + N+    L   S+  +
Sbjct: 139 SLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLR-RLEELDLGNNEIYNLP-ESIGAL 196

Query: 635 MNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNK 694
           +++ +L L   +L  +P  I +L NL  LD+  N +  + E IS   L  LT L +  N 
Sbjct: 197 LHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEIS--GLTSLTDLVISQNL 254

Query: 695 IVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNL 754
           + TIP  I  +K L  L    N+L  LP AV   + L  L ++ N +  +P  IG L+ L
Sbjct: 255 LETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKL 314

Query: 755 QHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLP 814
            +L+   NK+  LPK++  C  L    +  N +T +P +V Q ++L  L++ GN L  LP
Sbjct: 315 SNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLP 374

Query: 815 AQL 817
             L
Sbjct: 375 LSL 377



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 86/334 (25%), Positives = 156/334 (46%), Gaps = 24/334 (7%)

Query: 479 LSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDH 538
           L+ +P++  +L +L  L +  I    +P  I  + NL  L L          + + LR  
Sbjct: 117 LTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLR-R 175

Query: 539 LRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSN 598
           L  L +   ++  +P  +  L +L++L+L GN  SE  + IG      L++L  L V  N
Sbjct: 176 LEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIG-----NLKNLLCLDVSEN 230

Query: 599 -LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSL 657
            L ++P  I+ +   LT LVI  +  + +  + + K+  ++ L++    L ++P A+   
Sbjct: 231 RLERLPEEISGLTS-LTDLVISQNLLETIP-DGIGKLKKLSILKVDQNRLTQLPEAVGEC 288

Query: 658 SNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNK 717
            +L EL L  N + T+ + I    LK+L+ L    NK+V++P  I    +L      +N+
Sbjct: 289 ESLTELVLTENQLLTLPKSIG--KLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNR 346

Query: 718 LESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDIL---------- 767
           L  +P  V    +L  LDV+ N +  +P+ +  L+ L+ L ++ N+   L          
Sbjct: 347 LTRIPAEVSQATELHVLDVAGNRLLHLPLSLTALK-LKALWLSDNQSQPLLTFQTDTDYT 405

Query: 768 -PKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQL 800
             +++  C+ L  L     C  +LP + G L  L
Sbjct: 406 TGEKILTCVLLPQLPSEPTCQENLP-RCGALENL 438


>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
          Length = 582

 Score =  119 bits (299), Expect = 9e-27
 Identities = 74/234 (31%), Positives = 131/234 (55%), Gaps = 10/234 (4%)

Query: 613 LTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRT 672
           L+K  IH      ++ +S+K++  + EL L + +L+ +P  +  L NL  L L  N++ +
Sbjct: 107 LSKRSIH------ILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTS 160

Query: 673 IEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLR 732
           + +  S  +LK+L  L L HNK+  IP  +  + +L +LY   N++ ++   + +L KL 
Sbjct: 161 LPD--SLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLS 218

Query: 733 CLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPE 792
            L +  N I  +P EIG L NL  L +  N+++ LPK++  C ++  L+L  N +  LP+
Sbjct: 219 MLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPD 278

Query: 793 KVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEVKEAL 846
            +G LS L++L L+ N L  +P  L +C  L++  L +E++   TLP  +  +L
Sbjct: 279 TIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEE--LNLENNNISTLPESLLSSL 330



 Score =  119 bits (298), Expect = 1e-26
 Identities = 99/365 (27%), Positives = 178/365 (48%), Gaps = 24/365 (6%)

Query: 488 DLTDLDVLKLELIPEAKI---PAKISQMTNLQELHLCH-----CPAKVEQTAFSFLRDHL 539
           D+ +L  L +  I E KI   PA+I ++ NL  L + H      P ++           +
Sbjct: 210 DIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCT------QI 263

Query: 540 RCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNL 599
             L ++  ++ ++P  +  L +L  L L  N  S   + +   S  E  +L+     +N+
Sbjct: 264 TNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLE----NNNI 319

Query: 600 TKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSN 659
           + +P ++      L  L +  +  +L  +    +   +  L +++  + +IP  IFS + 
Sbjct: 320 STLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAK 379

Query: 660 -LQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKL 718
            L +L++K N + ++   + F     +  L L  N++  IP  ++ + +LE L  SNN L
Sbjct: 380 VLSKLNMKDNQLTSLP--LDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLL 437

Query: 719 ESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLR 778
           + LP  + +L+KLR LD+  N +  +P EI  L++LQ L +T N++  LP+ +     L 
Sbjct: 438 KKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLT 497

Query: 779 TLNLGQNCITSLPEKVGQLSQLTQLELKGN-CLDRLPAQLGQCRMLKKSGLVVEDHLFDT 837
            L LG+N +T LPE++G L  L +L L  N  L  LP +L  C   K S + +E+     
Sbjct: 498 HLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALCS--KLSIMSIENCPLSH 555

Query: 838 LPLEV 842
           LP ++
Sbjct: 556 LPPQI 560



 Score =  115 bits (289), Expect = 1e-25
 Identities = 102/401 (25%), Positives = 190/401 (47%), Gaps = 38/401 (9%)

Query: 471 KQELHLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQT 530
           K+ +H+     +P ++ +LT L  L L       +PA++  + NL  L L          
Sbjct: 109 KRSIHI-----LPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPD 163

Query: 531 AFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHL 590
           +   L+  LR L ++   + EIP+ VY L +L  LYL  N  +   K      ++ L  L
Sbjct: 164 SLDNLKK-LRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEK-----DIKNLSKL 217

Query: 591 KILHVKSN-LTKVPSNITDVAPHLTKLVIHN--------------------DGTKLLVL- 628
            +L ++ N + ++P+ I ++   +T  V HN                       +LL L 
Sbjct: 218 SMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLP 277

Query: 629 NSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCL 688
           +++  + +++ L L+   L  IP ++   S L+EL+L++NNI T+ E +    L +L  L
Sbjct: 278 DTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESL-LSSLVKLNSL 336

Query: 689 KLWHNKIVTIP-PSITHVKNLESLYFSNNKLESLPVAVFSLQK-LRCLDVSYNNISMIPI 746
            L  N     P    +    + SL   +N++  +P  +FS  K L  L++  N ++ +P+
Sbjct: 337 TLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPL 396

Query: 747 EIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELK 806
           + G   ++  L++  N++  +P+ +   + L  L L  N +  LP  +G L +L +L+L+
Sbjct: 397 DFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLE 456

Query: 807 GNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEVKEALN 847
            N L+ LP ++   + L+K  LV+ ++   TLP  +    N
Sbjct: 457 ENKLESLPNEIAYLKDLQK--LVLTNNQLTTLPRGIGHLTN 495



 Score = 80.9 bits (198), Expect = 5e-15
 Identities = 55/178 (30%), Positives = 96/178 (53%), Gaps = 5/178 (2%)

Query: 666 KSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAV 725
           KS+N   I+E+   +    +  L L    I  +P SI  +  L  LY  +NKL+SLP  V
Sbjct: 84  KSSNAEVIKELNKCREENSMR-LDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEV 142

Query: 726 FSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQN 785
             L  L  L +S N+++ +P  +  L+ L+ L +  NK+  +P  +++   L TL L  N
Sbjct: 143 GCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFN 202

Query: 786 CITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQ-CRMLKKSGLVVEDHLFDTLPLEV 842
            IT++ + +  LS+L+ L ++ N + +LPA++G+ C ++    L V  +  + LP E+
Sbjct: 203 RITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLIT---LDVAHNQLEHLPKEI 257


>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
          Length = 1537

 Score =  117 bits (292), Expect = 6e-26
 Identities = 89/323 (27%), Positives = 161/323 (49%), Gaps = 31/323 (9%)

Query: 539 LRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSN 598
           LR L +   D++ +P  +  L NL+EL +     S+N      E+++  + L I+    N
Sbjct: 71  LRKLSIPDNDLSNLPTTIASLVNLKELDI-----SKNGVQEFPENIKCCKCLTIIEASVN 125

Query: 599 -LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSL 657
            ++K+P   T +  +LT+L +++   + L  N   +++ +  LEL+   L+ +P ++  L
Sbjct: 126 PISKLPDGFTQLL-NLTQLYLNDAFLEFLPAN-FGRLVKLRILELRENHLKTLPKSMHKL 183

Query: 658 SNLQELDLKSNNIRTIEEII---------------------SFQHLKRLTCLKLWHNKIV 696
           + L+ LDL +N    + E++                     S   LK L  L +  N+I 
Sbjct: 184 AQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIE 243

Query: 697 TIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQH 756
           T+   I+  + LE L  S+N L+ LP ++  L+KL  L V  N ++M+P  IG L  L+ 
Sbjct: 244 TVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEE 303

Query: 757 LHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQ 816
              + N+++ LP  +     LRTL + +N +  LP ++G    +T + L+ N L+ LP +
Sbjct: 304 FDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEE 363

Query: 817 LGQCRMLKKSGLVVEDHLFDTLP 839
           +GQ + L+   L + D+    LP
Sbjct: 364 IGQMQKLRV--LNLSDNRLKNLP 384



 Score =  107 bits (266), Expect = 6e-23
 Identities = 95/378 (25%), Positives = 174/378 (46%), Gaps = 42/378 (11%)

Query: 455 WTFEKLRQHISRNAQDKQELHLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTN 514
           + FE+  + +  +A   +EL        P  +F+   L  L +     + +P  I+ + N
Sbjct: 42  FNFERTLEELYLDANQIEEL--------PKQLFNCQALRKLSIPDNDLSNLPTTIASLVN 93

Query: 515 LQELHLCHCPAKVEQTAFSFLRDHLRC------LHVKFTDVAEIPAWVYLLKNLRELYL- 567
           L+EL        + +       ++++C      +      ++++P     L NL +LYL 
Sbjct: 94  LKELD-------ISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLN 146

Query: 568 ----------IGNLNS-------ENNKMIGLESLRELRHLKILHVKSNLTKVPSNITDVA 610
                      G L         EN+     +S+ +L  L+ L + +N       + D  
Sbjct: 147 DAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQI 206

Query: 611 PHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNI 670
            +L +L + N+  ++L   S+ K+  +  L++    +E +   I     L++L L SN +
Sbjct: 207 QNLRELWMDNNALQVLP-GSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNML 265

Query: 671 RTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQK 730
           + + + I    LK+LT LK+  N++  +P +I ++  LE    S N+LESLP  +  L  
Sbjct: 266 QQLPDSIGL--LKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHS 323

Query: 731 LRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSL 790
           LR L V  N +  +P EIG  +N+  + +  NK++ LP+++ +  KLR LNL  N + +L
Sbjct: 324 LRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNL 383

Query: 791 PEKVGQLSQLTQLELKGN 808
           P    +L +L  L L  N
Sbjct: 384 PFSFTKLKELAALWLSDN 401



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 52/156 (33%), Positives = 80/156 (51%), Gaps = 3/156 (1%)

Query: 685 LTCLKLWHNKIVTIPPSITHV-KNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISM 743
           ++ L   H  +  +P  + +  + LE LY   N++E LP  +F+ Q LR L +  N++S 
Sbjct: 24  ISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSN 83

Query: 744 IPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQL 803
           +P  I  L NL+ L I+ N V   P+ +  C  L  +    N I+ LP+   QL  LTQL
Sbjct: 84  LPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQL 143

Query: 804 ELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLP 839
            L    L+ LPA  G  R++K   L + ++   TLP
Sbjct: 144 YLNDAFLEFLPANFG--RLVKLRILELRENHLKTLP 177



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 73/291 (25%), Positives = 134/291 (46%), Gaps = 21/291 (7%)

Query: 479 LSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQ-----ELHLCHCPAKVEQTAFS 533
           +S +PD    L +L  L L       +PA   ++  L+     E HL   P  + + A  
Sbjct: 127 ISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLA-- 184

Query: 534 FLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLE-SLRELRHLKI 592
                L  L +   +  E+P  +  ++NLREL++      +NN +  L  S+ +L+ L  
Sbjct: 185 ----QLERLDLGNNEFGELPEVLDQIQNLRELWM------DNNALQVLPGSIGKLKMLVY 234

Query: 593 LHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPH 652
           L +  N  +           L  L++ ++  + L  +S+  +  +  L++ + +L  +P+
Sbjct: 235 LDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLP-DSIGLLKKLTTLKVDDNQLTMLPN 293

Query: 653 AIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLY 712
            I +LS L+E D   N + ++   I + H   L  L +  N +  +P  I   KN+  + 
Sbjct: 294 TIGNLSLLEEFDCSCNELESLPSTIGYLH--SLRTLAVDENFLPELPREIGSCKNVTVMS 351

Query: 713 FSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNK 763
             +NKLE LP  +  +QKLR L++S N +  +P     L+ L  L ++ N+
Sbjct: 352 LRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQ 402



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 58/226 (25%), Positives = 101/226 (44%), Gaps = 49/226 (21%)

Query: 637 VAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIV 696
           ++ L+  +C L+++P  +F+              RT+EE            L L  N+I 
Sbjct: 24  ISVLDYSHCSLQQVPKEVFNFE------------RTLEE------------LYLDANQIE 59

Query: 697 TIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNN---------------- 740
            +P  + + + L  L   +N L +LP  + SL  L+ LD+S N                 
Sbjct: 60  ELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTI 119

Query: 741 -------ISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEK 793
                  IS +P     L NL  L++    ++ LP    + +KLR L L +N + +LP+ 
Sbjct: 120 IEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKS 179

Query: 794 VGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLP 839
           + +L+QL +L+L  N    LP  L Q + L++  L ++++    LP
Sbjct: 180 MHKLAQLERLDLGNNEFGELPEVLDQIQNLRE--LWMDNNALQVLP 223


>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
          Length = 1302

 Score =  110 bits (276), Expect = 4e-24
 Identities = 87/323 (26%), Positives = 153/323 (47%), Gaps = 31/323 (9%)

Query: 539 LRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSN 598
           L  L +   D+  +PA +  L NLREL +     S+N      E+++  + L I+    N
Sbjct: 71  LHKLSLPDNDLTTLPASIANLINLRELDV-----SKNGIQEFPENIKNCKVLTIVEASVN 125

Query: 599 -LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSL 657
            ++K+P   + +  +LT+L +++   + L  N   ++  +  LEL+  +L+ +P  +  L
Sbjct: 126 PISKLPDGFSQLL-NLTQLYLNDAFLEFLPAN-FGRLTKLQILELRENQLKMLPKTMNRL 183

Query: 658 SNLQELDLKSNNIRTIEEIIS---------------------FQHLKRLTCLKLWHNKIV 696
           + L+ LDL SN    + E++                         LK+LT L +  N I 
Sbjct: 184 TQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIE 243

Query: 697 TIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQH 756
            +   I+  +NL+ L  S+N L+ LP  + SL+ +  L +  N +  +P  IG L +++ 
Sbjct: 244 MVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEE 303

Query: 757 LHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQ 816
           L  + N+V+ LP  + +   LRT     N +  LP ++G    +T L L  N L+ LP +
Sbjct: 304 LDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEE 363

Query: 817 LGQCRMLKKSGLVVEDHLFDTLP 839
           +G  + LK   L   D+    LP
Sbjct: 364 MGDMQKLKVINL--SDNRLKNLP 384



 Score =  110 bits (274), Expect = 7e-24
 Identities = 100/380 (26%), Positives = 175/380 (46%), Gaps = 46/380 (12%)

Query: 455 WTFEKLRQHISRNAQDKQELHLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTN 514
           +TFEK  + +  +A   +EL        P  +F+   L  L L       +PA I+ + N
Sbjct: 42  FTFEKTLEELYLDANQIEEL--------PKQLFNCQSLHKLSLPDNDLTTLPASIANLIN 93

Query: 515 LQELHLC-----HCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYL-- 567
           L+EL +        P  ++          L  +      ++++P     L NL +LYL  
Sbjct: 94  LRELDVSKNGIQEFPENIKNCKV------LTIVEASVNPISKLPDGFSQLLNLTQLYLND 147

Query: 568 ---------IGNLNS-------ENNKMIGLESLRELRHLKILHVKSN-LTKVPSNITDVA 610
                     G L         EN   +  +++  L  L+ L + SN  T+VP    +V 
Sbjct: 148 AFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVP----EVL 203

Query: 611 PHLTKLV-IHNDGTKLLVLNS-LKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSN 668
             L+ L     D  +L  +   +  +  +  L++    +E +   I +  NLQ+L L SN
Sbjct: 204 EQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSN 263

Query: 669 NIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSL 728
           +++ + E I    LK +T LK+  N+++ +P SI  + ++E L  S N++E+LP ++  L
Sbjct: 264 SLQQLPETIG--SLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQL 321

Query: 729 QKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCIT 788
             LR     +N +  +P EIG  +N+  L +  NK++ LP+++    KL+ +NL  N + 
Sbjct: 322 TNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLK 381

Query: 789 SLPEKVGQLSQLTQLELKGN 808
           +LP    +L QLT + L  N
Sbjct: 382 NLPFSFTKLQQLTAMWLSDN 401



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 74/285 (25%), Positives = 135/285 (47%), Gaps = 9/285 (3%)

Query: 479 LSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDH 538
           +S +PD    L +L  L L       +PA   ++T LQ L L     K+     + L   
Sbjct: 127 ISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQ- 185

Query: 539 LRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSN 598
           L  L +   +  E+P  +  L  L+E ++  N  +     IG  SL++L +L +   K+N
Sbjct: 186 LERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIG--SLKQLTYLDVS--KNN 241

Query: 599 LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLS 658
           +  V   I+    +L  L++ ++  + L   ++  + N+  L++   +L  +P +I  L 
Sbjct: 242 IEMVEEGIS-TCENLQDLLLSSNSLQQLP-ETIGSLKNITTLKIDENQLMYLPDSIGGLI 299

Query: 659 NLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKL 718
           +++ELD   N +  +   I    L  L      HN +  +PP I   KN+  L+  +NKL
Sbjct: 300 SVEELDCSFNEVEALPSSIG--QLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKL 357

Query: 719 ESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNK 763
           E+LP  +  +QKL+ +++S N +  +P     LQ L  + ++ N+
Sbjct: 358 ETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQ 402



 Score = 77.4 bits (189), Expect = 5e-14
 Identities = 51/156 (32%), Positives = 77/156 (49%), Gaps = 3/156 (1%)

Query: 685 LTCLKLWHNKIVTIPPSI-THVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISM 743
           +T L   H  +  +P  I T  K LE LY   N++E LP  +F+ Q L  L +  N+++ 
Sbjct: 24  VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83

Query: 744 IPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQL 803
           +P  I  L NL+ L ++ N +   P+ +  C  L  +    N I+ LP+   QL  LTQL
Sbjct: 84  LPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQL 143

Query: 804 ELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLP 839
            L    L+ LPA  G  R+ K   L + ++    LP
Sbjct: 144 YLNDAFLEFLPANFG--RLTKLQILELRENQLKMLP 177



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 54/192 (28%), Positives = 87/192 (45%), Gaps = 24/192 (12%)

Query: 637 VAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIV 696
           V  L+  +C LE++P  IF+              +T+EE            L L  N+I 
Sbjct: 24  VTTLDYSHCSLEQVPKEIFTFE------------KTLEE------------LYLDANQIE 59

Query: 697 TIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQH 756
            +P  + + ++L  L   +N L +LP ++ +L  LR LDVS N I   P  I   + L  
Sbjct: 60  ELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTI 119

Query: 757 LHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQ 816
           +  + N +  LP    + + L  L L    +  LP   G+L++L  LEL+ N L  LP  
Sbjct: 120 VEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKT 179

Query: 817 LGQCRMLKKSGL 828
           + +   L++  L
Sbjct: 180 MNRLTQLERLDL 191


>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
          Length = 1371

 Score =  110 bits (276), Expect = 4e-24
 Identities = 87/323 (26%), Positives = 153/323 (47%), Gaps = 31/323 (9%)

Query: 539 LRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSN 598
           L  L +   D+  +PA +  L NLREL +     S+N      E+++  + L I+    N
Sbjct: 71  LHKLSLPDNDLTTLPASIANLINLRELDV-----SKNGIQEFPENIKNCKVLTIVEASVN 125

Query: 599 -LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSL 657
            ++K+P   + +  +LT+L +++   + L  N   ++  +  LEL+  +L+ +P  +  L
Sbjct: 126 PISKLPDGFSQLL-NLTQLYLNDAFLEFLPAN-FGRLTKLQILELRENQLKMLPKTMNRL 183

Query: 658 SNLQELDLKSNNIRTIEEIIS---------------------FQHLKRLTCLKLWHNKIV 696
           + L+ LDL SN    + E++                         LK+LT L +  N I 
Sbjct: 184 TQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIE 243

Query: 697 TIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQH 756
            +   I+  +NL+ L  S+N L+ LP  + SL+ +  L +  N +  +P  IG L +++ 
Sbjct: 244 MVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEE 303

Query: 757 LHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQ 816
           L  + N+V+ LP  + +   LRT     N +  LP ++G    +T L L  N L+ LP +
Sbjct: 304 LDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEE 363

Query: 817 LGQCRMLKKSGLVVEDHLFDTLP 839
           +G  + LK   L   D+    LP
Sbjct: 364 MGDMQKLKVINL--SDNRLKNLP 384



 Score =  110 bits (274), Expect = 7e-24
 Identities = 100/380 (26%), Positives = 175/380 (46%), Gaps = 46/380 (12%)

Query: 455 WTFEKLRQHISRNAQDKQELHLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTN 514
           +TFEK  + +  +A   +EL        P  +F+   L  L L       +PA I+ + N
Sbjct: 42  FTFEKTLEELYLDANQIEEL--------PKQLFNCQSLHKLSLPDNDLTTLPASIANLIN 93

Query: 515 LQELHLC-----HCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYL-- 567
           L+EL +        P  ++          L  +      ++++P     L NL +LYL  
Sbjct: 94  LRELDVSKNGIQEFPENIKNCKV------LTIVEASVNPISKLPDGFSQLLNLTQLYLND 147

Query: 568 ---------IGNLNS-------ENNKMIGLESLRELRHLKILHVKSN-LTKVPSNITDVA 610
                     G L         EN   +  +++  L  L+ L + SN  T+VP    +V 
Sbjct: 148 AFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVP----EVL 203

Query: 611 PHLTKLV-IHNDGTKLLVLNS-LKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSN 668
             L+ L     D  +L  +   +  +  +  L++    +E +   I +  NLQ+L L SN
Sbjct: 204 EQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSN 263

Query: 669 NIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSL 728
           +++ + E I    LK +T LK+  N+++ +P SI  + ++E L  S N++E+LP ++  L
Sbjct: 264 SLQQLPETIG--SLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQL 321

Query: 729 QKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCIT 788
             LR     +N +  +P EIG  +N+  L +  NK++ LP+++    KL+ +NL  N + 
Sbjct: 322 TNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLK 381

Query: 789 SLPEKVGQLSQLTQLELKGN 808
           +LP    +L QLT + L  N
Sbjct: 382 NLPFSFTKLQQLTAMWLSDN 401



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 74/285 (25%), Positives = 135/285 (47%), Gaps = 9/285 (3%)

Query: 479 LSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDH 538
           +S +PD    L +L  L L       +PA   ++T LQ L L     K+     + L   
Sbjct: 127 ISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQ- 185

Query: 539 LRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSN 598
           L  L +   +  E+P  +  L  L+E ++  N  +     IG  SL++L +L +   K+N
Sbjct: 186 LERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIG--SLKQLTYLDVS--KNN 241

Query: 599 LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLS 658
           +  V   I+    +L  L++ ++  + L   ++  + N+  L++   +L  +P +I  L 
Sbjct: 242 IEMVEEGIS-TCENLQDLLLSSNSLQQLP-ETIGSLKNITTLKIDENQLMYLPDSIGGLI 299

Query: 659 NLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKL 718
           +++ELD   N +  +   I    L  L      HN +  +PP I   KN+  L+  +NKL
Sbjct: 300 SVEELDCSFNEVEALPSSIG--QLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKL 357

Query: 719 ESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNK 763
           E+LP  +  +QKL+ +++S N +  +P     LQ L  + ++ N+
Sbjct: 358 ETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQ 402



 Score = 77.4 bits (189), Expect = 5e-14
 Identities = 51/156 (32%), Positives = 77/156 (49%), Gaps = 3/156 (1%)

Query: 685 LTCLKLWHNKIVTIPPSI-THVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISM 743
           +T L   H  +  +P  I T  K LE LY   N++E LP  +F+ Q L  L +  N+++ 
Sbjct: 24  VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83

Query: 744 IPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQL 803
           +P  I  L NL+ L ++ N +   P+ +  C  L  +    N I+ LP+   QL  LTQL
Sbjct: 84  LPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQL 143

Query: 804 ELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLP 839
            L    L+ LPA  G  R+ K   L + ++    LP
Sbjct: 144 YLNDAFLEFLPANFG--RLTKLQILELRENQLKMLP 177



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 54/192 (28%), Positives = 87/192 (45%), Gaps = 24/192 (12%)

Query: 637 VAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIV 696
           V  L+  +C LE++P  IF+              +T+EE            L L  N+I 
Sbjct: 24  VTTLDYSHCSLEQVPKEIFTFE------------KTLEE------------LYLDANQIE 59

Query: 697 TIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQH 756
            +P  + + ++L  L   +N L +LP ++ +L  LR LDVS N I   P  I   + L  
Sbjct: 60  ELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTI 119

Query: 757 LHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQ 816
           +  + N +  LP    + + L  L L    +  LP   G+L++L  LEL+ N L  LP  
Sbjct: 120 VEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKT 179

Query: 817 LGQCRMLKKSGL 828
           + +   L++  L
Sbjct: 180 MNRLTQLERLDL 191


>gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens]
          Length = 277

 Score =  110 bits (274), Expect = 7e-24
 Identities = 65/185 (35%), Positives = 101/185 (54%), Gaps = 25/185 (13%)

Query: 659 NLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKL 718
           N  E+D+    I  + ++     L  +T L L HNK+  +PP+I  +KNLE L F NN++
Sbjct: 16  NQPEVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQI 75

Query: 719 ESLPVAVFSLQKLR-----------------------CLDVSYNNIS--MIPIEIGLLQN 753
           E LP  + SLQKL+                        LD++YNN+S   +P     L  
Sbjct: 76  EELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTT 135

Query: 754 LQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRL 813
           L+ L+++ N  +ILP  + K  KL+ L+L  N + SLP+++G+L+QL +L ++GN L  L
Sbjct: 136 LRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVL 195

Query: 814 PAQLG 818
           P +LG
Sbjct: 196 PPELG 200



 Score = 70.5 bits (171), Expect = 6e-12
 Identities = 56/197 (28%), Positives = 90/197 (45%), Gaps = 26/197 (13%)

Query: 576 NKMIGLESLRELRHLKILHVKSN-LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKM 634
           + M+ +  L  L H+  L +  N LT VP NI ++  +L  L   N+  + L    +  +
Sbjct: 28  SNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELK-NLEVLNFFNNQIEELP-TQISSL 85

Query: 635 MNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNK 694
             +  L L    L  +P    SL  L+ LDL  NN+                        
Sbjct: 86  QKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSE---------------------- 123

Query: 695 IVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNL 754
             ++P +  ++  L +LY S+N  E LP  +  L KL+ L +  N++  +P EIG L  L
Sbjct: 124 -NSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQL 182

Query: 755 QHLHITGNKVDILPKQL 771
           + LHI GN++ +LP +L
Sbjct: 183 KELHIQGNRLTVLPPEL 199



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 31/108 (28%), Positives = 51/108 (47%), Gaps = 2/108 (1%)

Query: 734 LDVSYNNISMIPIEIGL--LQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLP 791
           +D+S   IS +    GL  L ++  L ++ NK+ ++P  + +   L  LN   N I  LP
Sbjct: 20  VDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELP 79

Query: 792 EKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLP 839
            ++  L +L  L L  N L+ LP   G    L+   L   +   ++LP
Sbjct: 80  TQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLP 127


>gi|45827729 scribble isoform b [Homo sapiens]
          Length = 1630

 Score =  110 bits (274), Expect = 7e-24
 Identities = 98/341 (28%), Positives = 166/341 (48%), Gaps = 12/341 (3%)

Query: 479 LSGVPDAVFDLT-DLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPA-KVEQTAFSFLR 536
           L  VP+ ++  +  L+ L L+     ++P    ++ NL++L L      ++     +F++
Sbjct: 24  LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ 83

Query: 537 DHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVK 596
             L  L V   D+ EIP  +   K L      GN  S      G   LR L HL +  V 
Sbjct: 84  --LVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPD--GFTQLRSLAHLALNDV- 138

Query: 597 SNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFS 656
            +L  +P ++ ++A +L  L +  +  K L   SL  ++ + +L+L   +LE +P  + +
Sbjct: 139 -SLQALPGDVGNLA-NLVTLELRENLLKSLPA-SLSFLVKLEQLDLGGNDLEVLPDTLGA 195

Query: 657 LSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNN 716
           L NL+EL L  N +  +   +   +L+RL CL +  N++  +P  +  +  L  L  S N
Sbjct: 196 LPNLRELWLDRNQLSALPPELG--NLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQN 253

Query: 717 KLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIK 776
            L  LP  +  L++L  L V  N +  +   IG  +NL  L +T N +  LP+ L K  K
Sbjct: 254 LLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTK 313

Query: 777 LRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQL 817
           L  LN+ +N + +LP ++G    L+ L L+ N L  LP +L
Sbjct: 314 LTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPEL 354



 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 79/287 (27%), Positives = 132/287 (45%), Gaps = 49/287 (17%)

Query: 598 NLTKVPSNITDVAPHLTKLVIHNDGTKLLVL-NSLKKMMNVAELELQNCELERIPHAIFS 656
           +L  VP  I   +  L +L++  D  +L  L     +++N+ +L L + E++R+P  + +
Sbjct: 23  SLQAVPEEIYRYSRSLEELLL--DANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVAN 80

Query: 657 LSNLQELDLKSNNIRTIEEIISF------------------------------------- 679
              L ELD+  N+I  I E I F                                     
Sbjct: 81  FMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSL 140

Query: 680 -------QHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLR 732
                   +L  L  L+L  N + ++P S++ +  LE L    N LE LP  + +L  LR
Sbjct: 141 QALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLR 200

Query: 733 CLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPE 792
            L +  N +S +P E+G L+ L  L ++ N+++ LP +L   + L  L L QN +  LP+
Sbjct: 201 ELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPD 260

Query: 793 KVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLP 839
            +GQL QL+ L++  N L  +   +G C  L  S L++ ++L   LP
Sbjct: 261 GIGQLKQLSILKVDQNRLCEVTEAIGDCENL--SELILTENLLMALP 305



 Score = 64.3 bits (155), Expect = 5e-10
 Identities = 73/273 (26%), Positives = 115/273 (42%), Gaps = 32/273 (11%)

Query: 479 LSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDH 538
           LS +PD    L  L  L L  +    +P  +  + NL  L L     K    + SFL   
Sbjct: 117 LSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVK- 175

Query: 539 LRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLE-SLRELRHLKILHVKS 597
           L  L +   D+  +P  +  L NLREL+L      + N++  L   L  LR L  L V  
Sbjct: 176 LEQLDLGGNDLEVLPDTLGALPNLRELWL------DRNQLSALPPELGNLRRLVCLDVSE 229

Query: 598 N-LTKVPSNITDVAPHLTKLVIHN------DGTKLLVLNSLKKM---------------M 635
           N L ++P+ +  +      L+  N      DG   L   S+ K+                
Sbjct: 230 NRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCE 289

Query: 636 NVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKI 695
           N++EL L    L  +P ++  L+ L  L++  N++  +   I       L+ L L  N++
Sbjct: 290 NLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIG--GCVALSVLSLRDNRL 347

Query: 696 VTIPPSITHVKNLESLYFSNNKLESLPVAVFSL 728
             +PP + H   L  L  + N+L+SLP A+  L
Sbjct: 348 AVLPPELAHTTELHVLDVAGNRLQSLPFALTHL 380


>gi|45827731 scribble isoform a [Homo sapiens]
          Length = 1655

 Score =  110 bits (274), Expect = 7e-24
 Identities = 98/341 (28%), Positives = 166/341 (48%), Gaps = 12/341 (3%)

Query: 479 LSGVPDAVFDLT-DLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPA-KVEQTAFSFLR 536
           L  VP+ ++  +  L+ L L+     ++P    ++ NL++L L      ++     +F++
Sbjct: 24  LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ 83

Query: 537 DHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVK 596
             L  L V   D+ EIP  +   K L      GN  S      G   LR L HL +  V 
Sbjct: 84  --LVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPD--GFTQLRSLAHLALNDV- 138

Query: 597 SNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFS 656
            +L  +P ++ ++A +L  L +  +  K L   SL  ++ + +L+L   +LE +P  + +
Sbjct: 139 -SLQALPGDVGNLA-NLVTLELRENLLKSLPA-SLSFLVKLEQLDLGGNDLEVLPDTLGA 195

Query: 657 LSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNN 716
           L NL+EL L  N +  +   +   +L+RL CL +  N++  +P  +  +  L  L  S N
Sbjct: 196 LPNLRELWLDRNQLSALPPELG--NLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQN 253

Query: 717 KLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIK 776
            L  LP  +  L++L  L V  N +  +   IG  +NL  L +T N +  LP+ L K  K
Sbjct: 254 LLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTK 313

Query: 777 LRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQL 817
           L  LN+ +N + +LP ++G    L+ L L+ N L  LP +L
Sbjct: 314 LTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPEL 354



 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 79/287 (27%), Positives = 132/287 (45%), Gaps = 49/287 (17%)

Query: 598 NLTKVPSNITDVAPHLTKLVIHNDGTKLLVL-NSLKKMMNVAELELQNCELERIPHAIFS 656
           +L  VP  I   +  L +L++  D  +L  L     +++N+ +L L + E++R+P  + +
Sbjct: 23  SLQAVPEEIYRYSRSLEELLL--DANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVAN 80

Query: 657 LSNLQELDLKSNNIRTIEEIISF------------------------------------- 679
              L ELD+  N+I  I E I F                                     
Sbjct: 81  FMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSL 140

Query: 680 -------QHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLR 732
                   +L  L  L+L  N + ++P S++ +  LE L    N LE LP  + +L  LR
Sbjct: 141 QALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLR 200

Query: 733 CLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPE 792
            L +  N +S +P E+G L+ L  L ++ N+++ LP +L   + L  L L QN +  LP+
Sbjct: 201 ELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPD 260

Query: 793 KVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLP 839
            +GQL QL+ L++  N L  +   +G C  L  S L++ ++L   LP
Sbjct: 261 GIGQLKQLSILKVDQNRLCEVTEAIGDCENL--SELILTENLLMALP 305



 Score = 64.3 bits (155), Expect = 5e-10
 Identities = 73/273 (26%), Positives = 115/273 (42%), Gaps = 32/273 (11%)

Query: 479 LSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDH 538
           LS +PD    L  L  L L  +    +P  +  + NL  L L     K    + SFL   
Sbjct: 117 LSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVK- 175

Query: 539 LRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLE-SLRELRHLKILHVKS 597
           L  L +   D+  +P  +  L NLREL+L      + N++  L   L  LR L  L V  
Sbjct: 176 LEQLDLGGNDLEVLPDTLGALPNLRELWL------DRNQLSALPPELGNLRRLVCLDVSE 229

Query: 598 N-LTKVPSNITDVAPHLTKLVIHN------DGTKLLVLNSLKKM---------------M 635
           N L ++P+ +  +      L+  N      DG   L   S+ K+                
Sbjct: 230 NRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCE 289

Query: 636 NVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKI 695
           N++EL L    L  +P ++  L+ L  L++  N++  +   I       L+ L L  N++
Sbjct: 290 NLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIG--GCVALSVLSLRDNRL 347

Query: 696 VTIPPSITHVKNLESLYFSNNKLESLPVAVFSL 728
             +PP + H   L  L  + N+L+SLP A+  L
Sbjct: 348 AVLPPELAHTTELHVLDVAGNRLQSLPFALTHL 380


>gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo
           sapiens]
          Length = 560

 Score =  109 bits (273), Expect = 9e-24
 Identities = 108/400 (27%), Positives = 190/400 (47%), Gaps = 39/400 (9%)

Query: 479 LSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCH------CPA------- 525
           L+ +P  +F  T+L+ + LE     +IP +I ++ N++ L+L        CPA       
Sbjct: 37  LTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPALGLLSSL 96

Query: 526 -----------KVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSE 574
                             SFL   LR L +  TD+ EIP  V + KNL  L L+G L   
Sbjct: 97  ESLDLSYNPIFSSSLVVVSFLHA-LRELRLYQTDLKEIP--VVIFKNLHHLELLG-LTGN 152

Query: 575 NNKMIGLESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKL-LVLNSLKK 633
           + K +  E + + + L+ +++K N  +V     ++    T  +I  D  K+  +   +  
Sbjct: 153 HLKCLPKEIVNQTK-LREIYLKRNQFEVFPQ--ELCVLYTLEIIDLDENKIGAIPEEIGH 209

Query: 634 MMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHN 693
           +  + +  + +  L  +P ++   S L  LDL  N + +I +  SF  L+++T + L  N
Sbjct: 210 LTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPK--SFAELRKMTEIGLSGN 267

Query: 694 KIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQN 753
           ++  +P  I    +L  LY  N  L  L  +   L  LR LD+S N++   P++I  L+N
Sbjct: 268 RLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKN 327

Query: 754 LQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLEL---KGNCL 810
           L+ L +  NK+  LP +L    KL+ L L  N   S PE+V  L+ L +L +   +G  L
Sbjct: 328 LEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKL 387

Query: 811 DRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEVKEALNQDI 850
             +P  + + + LK+  L +E++  + LP+ +    N ++
Sbjct: 388 TYVPEHIRKLQSLKE--LYIENNHLEYLPVSLGSMPNLEV 425



 Score = 90.9 bits (224), Expect = 5e-18
 Identities = 97/372 (26%), Positives = 165/372 (44%), Gaps = 32/372 (8%)

Query: 472 QELHLFM--LSGVPDAVF-DLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVE 528
           +EL L+   L  +P  +F +L  L++L L       +P +I   T L+E++L     +V 
Sbjct: 121 RELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVF 180

Query: 529 QTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGN-----------------L 571
                 L   L  + +    +  IP  +  L  L++ Y+  N                 L
Sbjct: 181 PQELCVLYT-LEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVL 239

Query: 572 NSENNKMIGL-ESLRELRHLKILHVKSN-LTKVPSNITD-VAPHLTKLVIHNDGTKLLVL 628
           +  +N +  + +S  ELR +  + +  N L KVP  I    + HL  L + N G   L  
Sbjct: 240 DLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHL--LYLGNTGLHRL-R 296

Query: 629 NSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCL 688
            S + ++N+  L+L    L   P  I +L NL+ L L  N I  +   +    L +L  L
Sbjct: 297 GSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELG--SLSKLKIL 354

Query: 689 KLWHNKIVTIPPSITHVKNLESLYFSNN---KLESLPVAVFSLQKLRCLDVSYNNISMIP 745
            L  N+ ++ P  +  + +LE LY   +   KL  +P  +  LQ L+ L +  N++  +P
Sbjct: 355 GLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLP 414

Query: 746 IEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLEL 805
           + +G + NL+ L    N +  LP  + +   L+ L L  N +T LPE +  L  L  L L
Sbjct: 415 VSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKVLTL 474

Query: 806 KGNCLDRLPAQL 817
             N ++  P ++
Sbjct: 475 MDNPMEEPPKEV 486



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 64/230 (27%), Positives = 113/230 (49%), Gaps = 29/230 (12%)

Query: 640 LELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIP 699
           ++  N  L  IP  IF+ + L+E+ L++N I  I + I  Q LK +  L L  N + ++ 
Sbjct: 30  IDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEI--QRLKNIRVLYLDKNNLRSLC 87

Query: 700 PSITHVKNLESLYFSNN------------------------KLESLPVAVF-SLQKLRCL 734
           P++  + +LESL  S N                         L+ +PV +F +L  L  L
Sbjct: 88  PALGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELL 147

Query: 735 DVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKV 794
            ++ N++  +P EI     L+ +++  N+ ++ P++L     L  ++L +N I ++PE++
Sbjct: 148 GLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEI 207

Query: 795 GQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEVKE 844
           G L+ L +  +  N L  LPA L QC  L  S L +  +L  ++P    E
Sbjct: 208 GHLTGLQKFYMASNNLPVLPASLCQCSQL--SVLDLSHNLLHSIPKSFAE 255


>gi|4503743 flightless I homolog [Homo sapiens]
          Length = 1269

 Score =  105 bits (263), Expect = 1e-22
 Identities = 90/333 (27%), Positives = 152/333 (45%), Gaps = 57/333 (17%)

Query: 480 SGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHL 539
           SGVPD +F L DL VL L      + P ++    N+  L+L H                L
Sbjct: 94  SGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDL 153

Query: 540 RCLHVKFTDVAEIPAWVYLLKNLRELYLIGN--LNSENNKMIGLESLRELRHLKILHVKS 597
             L +    +  +P  +  L +L+ L L GN  L+++      L  L  +  L+ LH++S
Sbjct: 154 LYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQ------LRQLPAMTALQTLHLRS 207

Query: 598 NLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSL 657
              +  SN+                       SL+ + N+A+++L   +L R+P  +++L
Sbjct: 208 T-QRTQSNLP---------------------TSLEGLSNLADVDLSCNDLTRVPECLYTL 245

Query: 658 SNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNK 717
            +L+ L+L SN I  +             C+  W            HV   E+L  S N+
Sbjct: 246 PSLRRLNLSSNQITELS-----------LCIDQW-----------VHV---ETLNLSRNQ 280

Query: 718 LESLPVAVFSLQKLRCLDVSYNNISM--IPIEIGLLQNLQHLHITGNKVDILPKQLFKCI 775
           L SLP A+  L KL+ L ++ N +    +P  IG L NL+      N ++++P+ L +C 
Sbjct: 281 LTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCP 340

Query: 776 KLRTLNLGQNCITSLPEKVGQLSQLTQLELKGN 808
           KLR L L +N + +LPE +  L+++  L+++ N
Sbjct: 341 KLRKLVLNKNHLVTLPEAIHFLTEIEVLDVREN 373



 Score = 90.9 bits (224), Expect = 5e-18
 Identities = 72/274 (26%), Positives = 141/274 (51%), Gaps = 33/274 (12%)

Query: 581 LESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLL-VLNSLKKMMNVAE 639
           L +L++L HL + H  +NLT +   ++ + P L  +V   +  K   V + + K+ +++ 
Sbjct: 52  LAALQKLEHLSVSH--NNLTTLHGELSSL-PSLRAIVARANSLKNSGVPDDIFKLDDLSV 108

Query: 640 LELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIP 699
           L+L + +L   P  + +  N+  L+L  N+I TI   + F +L  L  L L  N++ ++P
Sbjct: 109 LDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQL-FINLTDLLYLDLSENRLESLP 167

Query: 700 PSITHVKNLESLYFSNNKL--------------------------ESLPVAVFSLQKLRC 733
           P +  + +L++L  + N L                           +LP ++  L  L  
Sbjct: 168 PQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLAD 227

Query: 734 LDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEK 793
           +D+S N+++ +P  +  L +L+ L+++ N++  L   + + + + TLNL +N +TSLP  
Sbjct: 228 VDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSA 287

Query: 794 VGQLSQLTQLELKGNCL--DRLPAQLGQCRMLKK 825
           + +LS+L +L L  N L  D LP+ +G+   L++
Sbjct: 288 ICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEE 321



 Score = 84.0 bits (206), Expect = 6e-16
 Identities = 88/368 (23%), Positives = 164/368 (44%), Gaps = 48/368 (13%)

Query: 483 PDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRCL 542
           P+ V  +T L  LKL       +P +++ +  L+ L + H              ++L  L
Sbjct: 26  PENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSH--------------NNLTTL 71

Query: 543 HVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSN-LTK 601
           H + + +  + A            ++   NS  N  +  + + +L  L +L +  N LT+
Sbjct: 72  HGELSSLPSLRA------------IVARANSLKNSGVP-DDIFKLDDLSVLDLSHNQLTE 118

Query: 602 VPSNITDVAPHLTKLVIHNDGTKL---LVLNSLKKMMNVAELELQNCELERIPHAIFSLS 658
            P  + +    L   + HN    +   L +N    + ++  L+L    LE +P  +  L 
Sbjct: 119 CPRELENAKNMLVLNLSHNSIDTIPNQLFIN----LTDLLYLDLSENRLESLPPQMRRLV 174

Query: 659 NLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIV-----TIPPSITHVKNLESLYF 713
           +LQ L L  N +   +     + L  +T L+  H +        +P S+  + NL  +  
Sbjct: 175 HLQTLVLNGNPLLHAQ----LRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDL 230

Query: 714 SNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFK 773
           S N L  +P  +++L  LR L++S N I+ + + I    +++ L+++ N++  LP  + K
Sbjct: 231 SCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICK 290

Query: 774 CIKLRTLNLGQNCIT--SLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVE 831
             KL+ L L  N +    LP  +G+L+ L +     N L+ +P  L +C  L+K  LV+ 
Sbjct: 291 LSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRK--LVLN 348

Query: 832 DHLFDTLP 839
            +   TLP
Sbjct: 349 KNHLVTLP 356


>gi|238908508 leucine-rich repeat and death domain-containing
           protein [Homo sapiens]
          Length = 860

 Score =  105 bits (262), Expect = 2e-22
 Identities = 105/394 (26%), Positives = 184/394 (46%), Gaps = 48/394 (12%)

Query: 479 LSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQEL-----HLCHCPAKVEQTAFS 533
           LS +P  +  L +L +L +     + IP +ISQ+ N+++L     ++ + P+ +E     
Sbjct: 200 LSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLG-- 257

Query: 534 FLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGL-ESLRELRHLKI 592
               +L  L +    +  IP  +  LK LR L      N E N++    ++L  L  L  
Sbjct: 258 ----NLEILSLGKNKLRHIPDTLPSLKTLRVL------NLEYNQLTTFPKALCFLPKLIS 307

Query: 593 LHVKSNL-TKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIP 651
           L +  NL + +P  I ++    T L+ HN  T L V   + +++ + EL+L + +LE I 
Sbjct: 308 LDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAV--EIFQLLKIKELQLADNKLEVIS 365

Query: 652 HAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPP----------- 700
           H I +   L+ L L  N ++ I E IS   +  L CL L  NK+  +P            
Sbjct: 366 HKIENFRELRILILDKNLLKNIPEKISCCAM--LECLSLSDNKLTELPKYIHKLNNLRKL 423

Query: 701 ------------SITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEI 748
                        I+H+ N+ SL FS N +  +P+ + + QK+  +++SYN I   P+ +
Sbjct: 424 HVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGL 483

Query: 749 GLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGN 808
             L +L +L + GN +  +P  +    +L  L L +N +    E    L  L  L+L  N
Sbjct: 484 CALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKN 543

Query: 809 CLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEV 842
            + ++PA +    M+    L++  + F+T P E+
Sbjct: 544 QIKKIPASIS--NMISLHVLILCCNKFETFPREL 575



 Score =  102 bits (253), Expect = 2e-21
 Identities = 101/387 (26%), Positives = 167/387 (43%), Gaps = 47/387 (12%)

Query: 441 VSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLSGVPDAVFDLTDLDVLKLELI 500
           +S+NKL E+           + H++RN   K          + D +  L ++  L+    
Sbjct: 402 LSDNKLTELPKYIHKLNNLRKLHVNRNNMVK----------ITDCISHLNNICSLEFSGN 451

Query: 501 PEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLK 560
               +P +I     + ++ L +            L D L  L V    ++EIP  +   K
Sbjct: 452 IITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCAL-DSLYYLSVNGNYISEIPVDISFSK 510

Query: 561 NLRELYLIGNLNSENNKMIGLESLRELRHLKILHV-KSNLTKVPSNITDVAPHLTKLVIH 619
            L  L L     SEN  +I  E    L +LK L + K+ + K+P++I++           
Sbjct: 511 QLLHLEL-----SENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISN----------- 554

Query: 620 NDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISF 679
                         M+++  L L   + E  P  + +L NLQ LDL  N ++ I   I  
Sbjct: 555 --------------MISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDIC- 599

Query: 680 QHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSN---NKLESLPVAVFSLQKLRCLDV 736
            +LK +  L    N+ +  P  +  +++LE L  S     KL  LP  + ++ +L+ LD+
Sbjct: 600 -NLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDI 658

Query: 737 SYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQ 796
           S N I  IP  IG L+NL  LH   N++  LP  L     L+ LNL  N +T+LP  +  
Sbjct: 659 SNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYN 718

Query: 797 LSQLTQLELKGNCLDRLPAQLGQCRML 823
           +  L ++    N L R P ++ + + L
Sbjct: 719 IFSLKEINFDDNPLLRPPVEICKGKQL 745



 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 76/276 (27%), Positives = 137/276 (49%), Gaps = 9/276 (3%)

Query: 551 EIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSN-LTKVPSNITDV 609
           E P  +  +K ++ LYL  N   +     G +S  +L  L+IL ++ N L+ +PS I  +
Sbjct: 155 EFPKDILKIKYVKYLYLDKN---QIKTFQGADS-GDLLGLEILSLQENGLSSLPSEIQLL 210

Query: 610 APHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNN 669
                  V HN  +   +   + ++ N+ +L   N  +E  P  +  L NL+ L L  N 
Sbjct: 211 HNLRILNVSHNHISH--IPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNK 268

Query: 670 IRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQ 729
           +R I + +    LK L  L L +N++ T P ++  +  L SL  + N + SLP  +  L+
Sbjct: 269 LRHIPDTLP--SLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELK 326

Query: 730 KLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITS 789
            L  L + +N ++ + +EI  L  ++ L +  NK++++  ++    +LR L L +N + +
Sbjct: 327 NLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKN 386

Query: 790 LPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKK 825
           +PEK+   + L  L L  N L  LP  + +   L+K
Sbjct: 387 IPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRK 422



 Score = 93.2 bits (230), Expect = 9e-19
 Identities = 99/418 (23%), Positives = 174/418 (41%), Gaps = 77/418 (18%)

Query: 478 MLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRD 537
           ++S +P  + +L +L+ L ++      +  +I Q+  ++EL L     +V        R+
Sbjct: 314 LISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRE 373

Query: 538 ----------------------HLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSEN 575
                                  L CL +    + E+P +++ L NLR+L++     + N
Sbjct: 374 LRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHV-----NRN 428

Query: 576 NKMIGLESLRELRHLKILHVKSNL-TKVPSNITDVAPHLTKLVIHN------------DG 622
           N +   + +  L ++  L    N+ T VP  I +    +   + +N            D 
Sbjct: 429 NMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDS 488

Query: 623 TKLLVLNS---------LKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTI 673
              L +N          +     +  LEL   +L        SL NL+ LDL  N I+ I
Sbjct: 489 LYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKI 548

Query: 674 EEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRC 733
              IS  ++  L  L L  NK  T P  +  ++NL+ L  S N+L+ +   + +L+ ++ 
Sbjct: 549 PASIS--NMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQK 606

Query: 734 LDVSYNNISMIPIEIGLLQNLQHLHIT---GNKVDILPKQLFKCIKLRTLNLGQNCITSL 790
           L+ S N     PIE+  LQ+L+ L+I+   G K+  LP +L    +L+ L++  N I  +
Sbjct: 607 LNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREI 666

Query: 791 PEKVGQL-----------------------SQLTQLELKGNCLDRLPAQLGQCRMLKK 825
           P  +G+L                       + L QL L GN L  LP+ +     LK+
Sbjct: 667 PRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKE 724



 Score = 76.6 bits (187), Expect = 9e-14
 Identities = 99/420 (23%), Positives = 167/420 (39%), Gaps = 64/420 (15%)

Query: 479 LSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDH 538
           L  +PD +  L  L VL LE       P  +  +  L  L L            S L   
Sbjct: 269 LRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTG-------NLISSLPKE 321

Query: 539 LRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKM-IGLESLRELRHLKILHVKS 597
           +R L    T + +     +L   + +L  I  L   +NK+ +    +   R L+IL +  
Sbjct: 322 IRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDK 381

Query: 598 NLTK-VPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFS 656
           NL K +P  I+  A  + + +  +D     +   + K+ N+ +L +    + +I   I  
Sbjct: 382 NLLKNIPEKISCCA--MLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISH 439

Query: 657 LSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIV-------------------- 696
           L+N+  L+   N I  +   I  ++ +++  ++L +NKI+                    
Sbjct: 440 LNNICSLEFSGNIITDVP--IEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGN 497

Query: 697 ---TIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQN 753
               IP  I+  K L  L  S NKL        SL  L+ LD+  N I  IP  I  + +
Sbjct: 498 YISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMIS 557

Query: 754 LQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSL----------------------- 790
           L  L +  NK +  P++L     L+ L+L +N +  +                       
Sbjct: 558 LHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHF 617

Query: 791 PEKVGQLSQLTQL---ELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEVKEALN 847
           P ++ QL  L QL   ++KG  L RLP +L     LK+  L + ++    +P  + E  N
Sbjct: 618 PIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKE--LDISNNAIREIPRNIGELRN 675


>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
           [Homo sapiens]
          Length = 1052

 Score =  103 bits (258), Expect = 5e-22
 Identities = 99/356 (27%), Positives = 173/356 (48%), Gaps = 23/356 (6%)

Query: 493 DVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEI 552
           D L+    P+  +PA +    +++ L+L +   +            LR L ++    A +
Sbjct: 46  DALESPASPQLVLPANLG---DIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARL 102

Query: 553 PAWVYLLKNLRELYLIGNLNSENNKMIGL-----ESLRELRHLKILHVKSNLTKVPSNIT 607
           P  V  L      + +  L+  +N++  L      +LRELR L + H  + L  +P+ + 
Sbjct: 103 PPAVAELG-----HHLTELDVSHNRLTALGAEVVSALRELRKLNLSH--NQLPALPAQLG 155

Query: 608 DVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKS 667
            +A HL +L +  +    L  +SL  +  +  L++ + +L   P  +  L  L+ELD+ S
Sbjct: 156 ALA-HLEELDVSFNRLAHLP-DSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSS 213

Query: 668 NNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFS 727
           N +R + E IS   L+ L  L L   ++ T+P     + +LESL   NN L++LP     
Sbjct: 214 NRLRGLPEDISA--LRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSC 271

Query: 728 LQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCI 787
           LQ+L+ L++S N     P  +  L  L+ L+++ N++  +P  +    +L TL L  N I
Sbjct: 272 LQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRI 331

Query: 788 TSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGL-VVEDHLFDTLPLEV 842
             LP+ + +L+ L +L L+GN +  LP   GQ   L + GL  ++D+     P EV
Sbjct: 332 RYLPDSIVELTGLEELVLQGNQIAVLPDHFGQ---LSRVGLWKIKDNPLIQPPYEV 384



 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 76/261 (29%), Positives = 130/261 (49%), Gaps = 15/261 (5%)

Query: 602 VPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSN-L 660
           +P+N+ D+      L + N+G + +       + ++  L L+     R+P A+  L + L
Sbjct: 58  LPANLGDIEA----LNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHL 113

Query: 661 QELDLKSNNIRTI-EEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLE 719
            ELD+  N +  +  E++S   L+ L  L L HN++  +P  +  + +LE L  S N+L 
Sbjct: 114 TELDVSHNRLTALGAEVVSA--LRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLA 171

Query: 720 SLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRT 779
            LP ++  L +LR LDV +N ++  P ++  L  L+ L ++ N++  LP+ +     L+ 
Sbjct: 172 HLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKI 231

Query: 780 LNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQ---LGQCRMLKKSGLVVEDHLFD 836
           L L    + +LP    +L+ L  L L  N L  LPAQ   L + +ML  S  + E+    
Sbjct: 232 LWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAA 291

Query: 837 TLPLEVKEAL----NQDINIP 853
            LPL   E L    NQ  ++P
Sbjct: 292 LLPLAGLEELYLSRNQLTSVP 312



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 65/295 (22%), Positives = 115/295 (38%), Gaps = 56/295 (18%)

Query: 405 SFSDIPDVKNDFAFLLHMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHI 464
           S + +P +      L H+ ++ D  +++   +  S    ++LR + ++H       RQ +
Sbjct: 143 SHNQLPALPAQLGALAHL-EELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLL 201

Query: 465 SRNAQDKQELHLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCP 524
              A ++ ++    L G+P+ +  L  L +L L       +PA   ++ +L+ L L +  
Sbjct: 202 QLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNG 261

Query: 525 AKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESL 584
            +     FS L+  L+ L++      E PA +  L  L ELYL  N              
Sbjct: 262 LQALPAQFSCLQ-RLKMLNLSSNLFEEFPAALLPLAGLEELYLSRN-------------- 306

Query: 585 RELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQN 644
                         LT VPS I+ +   LT                         L L N
Sbjct: 307 -------------QLTSVPSLISGLGRLLT-------------------------LWLDN 328

Query: 645 CELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIP 699
             +  +P +I  L+ L+EL L+ N I  + +   F  L R+   K+  N ++  P
Sbjct: 329 NRIRYLPDSIVELTGLEELVLQGNQIAVLPD--HFGQLSRVGLWKIKDNPLIQPP 381


>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
          Length = 602

 Score =  103 bits (258), Expect = 5e-22
 Identities = 83/279 (29%), Positives = 145/279 (51%), Gaps = 11/279 (3%)

Query: 575 NNKMIGL-ESLRELRHLKILHVKSN-LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLK 632
           NNK+  L + LR L  L +L +  N LT +PS I ++  +L KL + ++  K+L    + 
Sbjct: 91  NNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELE-NLQKLNVSHNKLKILP-EEIT 148

Query: 633 KMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWH 692
            + N+  L LQ+ EL  I      LSNL++LDL +N++ T+    SF  L  L  L L  
Sbjct: 149 NLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVP--ASFSSLSSLVRLNLSS 206

Query: 693 NKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQ 752
           N++ ++P  I  +K L+ L  ++N LE++P  +  ++ L  L +  N +  +P E     
Sbjct: 207 NELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLP-EFPSCS 265

Query: 753 NLQHLHITGNKVDILPKQLFKCI-KLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLD 811
            L+ LH+  N++++L  +  K +  +  L+L  N + S+P+++  L  L +L+L  N + 
Sbjct: 266 LLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDIS 325

Query: 812 RLPAQLGQCRMLKKSGLVVEDHLFDTLPLEVKEALNQDI 850
            LP  LG    L    L +E +   T+  E+     Q++
Sbjct: 326 SLPYSLGN---LHLKFLALEGNPLRTIRREIISKGTQEV 361



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 63/235 (26%), Positives = 118/235 (50%), Gaps = 29/235 (12%)

Query: 613 LTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRT 672
           LTKL+I N+  + L  + L+ +  +  L++ + +L  +P AI  L NLQ+L++       
Sbjct: 84  LTKLIISNNKLQSLT-DDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVS------ 136

Query: 673 IEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLR 732
                              HNK+  +P  IT+++NL+ LY  +N+L  +      L  L 
Sbjct: 137 -------------------HNKLKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLE 177

Query: 733 CLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPE 792
            LD+S N+++ +P     L +L  L+++ N++  LP ++ +  +L+ L+   N + ++P 
Sbjct: 178 DLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPP 237

Query: 793 KVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEVKEALN 847
           ++  +  L  L L+ N L  LP +   C +LK+  L V ++  + L  E  + LN
Sbjct: 238 ELAGMESLELLYLRRNKLRFLP-EFPSCSLLKE--LHVGENQIEMLEAEHLKHLN 289



 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 46/167 (27%), Positives = 92/167 (55%), Gaps = 2/167 (1%)

Query: 658 SNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNK 717
           ++L +L + +N ++++ + +    L  LT L +  N++ ++P +I  ++NL+ L  S+NK
Sbjct: 82  TDLTKLIISNNKLQSLTDDLRL--LPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNK 139

Query: 718 LESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKL 777
           L+ LP  + +L+ L+CL + +N ++ I      L NL+ L ++ N +  +P        L
Sbjct: 140 LKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSL 199

Query: 778 RTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLK 824
             LNL  N + SLP ++ ++ +L  L+   N L+ +P +L     L+
Sbjct: 200 VRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLE 246



 Score = 84.3 bits (207), Expect = 4e-16
 Identities = 104/456 (22%), Positives = 201/456 (44%), Gaps = 109/456 (23%)

Query: 466 RNAQDKQELHLF--MLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHC 523
           R  ++ Q+L++    L  +P+ + +L +L  L L+      I     Q++NL++L L + 
Sbjct: 125 RELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNN 184

Query: 524 PAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNL-NSENNKMIGLE 582
                  +FS L   +R L++   ++  +PA +  +K L+ L    NL  +   ++ G+E
Sbjct: 185 HLTTVPASFSSLSSLVR-LNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGME 243

Query: 583 SLRELRHLKILHVKSN----LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVA 638
           SL      ++L+++ N    L + PS        L +L +  +  ++L    LK + ++ 
Sbjct: 244 SL------ELLYLRRNKLRFLPEFPS-----CSLLKELHVGENQIEMLEAEHLKHLNSIL 292

Query: 639 ELELQNCELERIPHAIFSLSNLQELDLKS----------------------NNIRTI--- 673
            L+L++ +L+ +P  I  L +L+ LDL +                      N +RTI   
Sbjct: 293 VLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLHLKFLALEGNPLRTIRRE 352

Query: 674 ------EEIISFQHLK----------------------------RLTCLKL--WHNKIVT 697
                 +E++ +   K                             +  LK+  + +K  T
Sbjct: 353 IISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYSDKQAT 412

Query: 698 IPPS--ITHVKN--LESLYFSNNKLESLPVAVFSLQKLRC-LDVSYNNISMIPIEIGLLQ 752
           + P      VK+  + S+ FS N+L  +P  +  L+++   +D+S+N +S I +E+ +LQ
Sbjct: 413 LIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQ 472

Query: 753 NLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPE-------------------- 792
            L  L +  N ++ LP+++   ++L+T+NL  N    LPE                    
Sbjct: 473 KLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGS 532

Query: 793 ----KVGQLSQLTQLELKGNCLDRLPAQLGQCRMLK 824
               K+  +  LT L+L+ N L ++P +LG C  L+
Sbjct: 533 VDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLR 568



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 92/409 (22%), Positives = 188/409 (45%), Gaps = 42/409 (10%)

Query: 473 ELHLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAF 532
           ++H   L+ +P A+ +L +L  L +       +P +I+ + NL+ L+L H         F
Sbjct: 111 DIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNELTCISEGF 170

Query: 533 SFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGN----LNSENNKMIGLE------ 582
             L  +L  L +    +  +PA    L +L  L L  N    L +E N+M  L+      
Sbjct: 171 EQL-SNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNS 229

Query: 583 --------SLRELRHLKILHVKSN----LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNS 630
                    L  +  L++L+++ N    L + PS        L +L +  +  ++L    
Sbjct: 230 NLLETIPPELAGMESLELLYLRRNKLRFLPEFPS-----CSLLKELHVGENQIEMLEAEH 284

Query: 631 LKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKL 690
           LK + ++  L+L++ +L+ +P  I  L +L+ LDL +N+I ++   +   HLK    L L
Sbjct: 285 LKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLHLK---FLAL 341

Query: 691 WHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGL 750
             N + TI   I      E L +  +K++    +    Q     + +    S   + I  
Sbjct: 342 EGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPS----QSESATETAMTLPSESRVNIHA 397

Query: 751 LQNLQHLHITGNKVDILPKQLFKCIK---LRTLNLGQNCITSLPEKVGQLSQL-TQLELK 806
           +  L+ L  +  +  ++P ++F  +K   + ++N  +N +  +P+++ +L ++ + ++L 
Sbjct: 398 IITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLS 457

Query: 807 GNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEVKEALN-QDINIPF 854
            N L  +  +L  C + K + L + ++  ++LP E++  +  Q IN+ F
Sbjct: 458 FNKLSFISLEL--CVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSF 504



 Score = 60.1 bits (144), Expect = 9e-09
 Identities = 85/390 (21%), Positives = 166/390 (42%), Gaps = 63/390 (16%)

Query: 441 VSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLSGVPDAVFDLTDLDVL----- 495
           +S N+L+  SL  E    K  +H+  N+         +L  +P  +  +  L++L     
Sbjct: 204 LSSNELK--SLPAEINRMKRLKHLDCNSN--------LLETIPPELAGMESLELLYLRRN 253

Query: 496 KLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAW 555
           KL  +PE          + L+ELH+     ++ +       + +  L ++   +  +P  
Sbjct: 254 KLRFLPE------FPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDE 307

Query: 556 VYLLKNLRELYLIGN--------LNSENNKMIGLES--LRELRH----------LKILH- 594
           + LL++L  L L  N        L + + K + LE   LR +R           LK L  
Sbjct: 308 IILLRSLERLDLSNNDISSLPYSLGNLHLKFLALEGNPLRTIRREIISKGTQEVLKYLRS 367

Query: 595 -VKSNLTKVPSNITDVAPHLT-------------KLVIHNDGTKLLVLNSL---KKMMNV 637
            +K +      + T+ A  L              K++ ++D    L+ + +    K   V
Sbjct: 368 KIKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIV 427

Query: 638 AELELQNCELERIPHAIFSLSNL-QELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIV 696
             +     +L  IP  +  L  +  ++DL  N +  I   +    L++LT L L +N + 
Sbjct: 428 TSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFIS--LELCVLQKLTFLDLRNNFLN 485

Query: 697 TIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMI-PIEIGLLQNLQ 755
           ++P  +  +  L+++  S N+ + LP  ++ +  L  + +S N +  + P ++ +++NL 
Sbjct: 486 SLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLT 545

Query: 756 HLHITGNKVDILPKQLFKCIKLRTLNLGQN 785
            L +  N +  +P +L  C+ LRTL L  N
Sbjct: 546 TLDLQNNDLLQIPPELGNCVNLRTLLLDGN 575



 Score = 39.3 bits (90), Expect = 0.016
 Identities = 45/191 (23%), Positives = 81/191 (42%), Gaps = 27/191 (14%)

Query: 482 VPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRC 541
           +PD VFD                + + I    N  +  LC  P ++ +     L++ +  
Sbjct: 414 IPDEVFDA---------------VKSNIVTSINFSKNQLCEIPKRMVE-----LKEMVSD 453

Query: 542 LHVKFTDVAEIPAWVYLLKNLRELYLIGN-LNSENNKMIGLESLRELRHLKILHVKSNLT 600
           + + F  ++ I   + +L+ L  L L  N LNS        E +  L  L+ +++  N  
Sbjct: 454 VDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLP------EEMESLVRLQTINLSFNRF 507

Query: 601 KVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNL 660
           K+   +      L  ++I N+    +    +K M N+  L+LQN +L +IP  + +  NL
Sbjct: 508 KMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNL 567

Query: 661 QELDLKSNNIR 671
           + L L  N  R
Sbjct: 568 RTLLLDGNPFR 578


>gi|4504379 leucine-rich repeat-containing G protein-coupled
           receptor 5 [Homo sapiens]
          Length = 907

 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 94/327 (28%), Positives = 142/327 (43%), Gaps = 36/327 (11%)

Query: 515 LQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSE 574
           LQ   L H P +  Q   S     L   H+ +      P+    L +LR L+L  N  +E
Sbjct: 121 LQNNQLRHVPTEALQNLRSLQSLRLDANHISYVP----PSCFSGLHSLRHLWLDDNALTE 176

Query: 575 NNKMIGLESLRELRHLKILHVKSN-LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKK 633
               I +++ R L  L+ + +  N +  +P         L  L +HN+    L       
Sbjct: 177 ----IPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDG 232

Query: 634 MMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEII---------------- 677
           + ++  L+L    L+  P AI +LSNL+EL   SNNIR+I E                  
Sbjct: 233 LHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNP 292

Query: 678 -------SFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFS-LQ 729
                  +FQHL  L  L L     +T  P +T   NLESL  +  ++ SLP  V + L 
Sbjct: 293 IQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLP 352

Query: 730 KLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLF-KCIKLRTLNLGQNCIT 788
            L+ LD+SYN +  +P    + Q LQ + +  N++  +    F + + LR+LNL  N I 
Sbjct: 353 NLQVLDLSYNLLEDLP-SFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIA 411

Query: 789 SL-PEKVGQLSQLTQLELKGNCLDRLP 814
            + P     L  L +L+L  N L   P
Sbjct: 412 IIHPNAFSTLPSLIKLDLSSNLLSSFP 438



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 70/247 (28%), Positives = 105/247 (42%), Gaps = 52/247 (21%)

Query: 539 LRCLHVKFTDVAEIPAWVYLLKNLREL-YLIGNLNSENNK-------------------M 578
           L  L + + ++ E P  +  L NL+EL +   N+ S   K                    
Sbjct: 236 LETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQF 295

Query: 579 IGLESLRELRHLKILHVK--SNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMN 636
           +G  + + L  L+ L +   S +T+ P ++T  A +L  L +       L      ++ N
Sbjct: 296 VGRSAFQHLPELRTLTLNGASQITEFP-DLTGTA-NLESLTLTGAQISSLPQTVCNQLPN 353

Query: 637 VAELELQNCELERIPHAIFSL-SNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKI 695
           +  L+L    LE +P   FS+   LQ++DL+ N I  I ++ +FQ L  L  L L  NKI
Sbjct: 354 LQVLDLSYNLLEDLPS--FSVCQKLQKIDLRHNEIYEI-KVDTFQQLLSLRSLNLAWNKI 410

Query: 696 VTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQ 755
             I P               N   +LP    SL K   LD+S N +S  PI    L  L 
Sbjct: 411 AIIHP---------------NAFSTLP----SLIK---LDLSSNLLSSFPIT--GLHGLT 446

Query: 756 HLHITGN 762
           HL +TGN
Sbjct: 447 HLKLTGN 453



 Score = 39.3 bits (90), Expect = 0.016
 Identities = 28/84 (33%), Positives = 44/84 (52%), Gaps = 3/84 (3%)

Query: 734 LDVSYNNIS-MIPIEIGLLQNLQHLHITGNKVDILPKQLFKCI-KLRTLNLGQNCITSLP 791
           LD+S NNIS ++P  +  L+ L+ L + GN +  +PK  F  +  L+ L L  N +  +P
Sbjct: 71  LDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVP 130

Query: 792 -EKVGQLSQLTQLELKGNCLDRLP 814
            E +  L  L  L L  N +  +P
Sbjct: 131 TEALQNLRSLQSLRLDANHISYVP 154


>gi|34577083 ras suppressor protein 1 isoform 2 [Homo sapiens]
          Length = 224

 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 54/146 (36%), Positives = 83/146 (56%), Gaps = 25/146 (17%)

Query: 698 IPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLR-----------------------CL 734
           +PP+I  +KNLE L F NN++E LP  + SLQKL+                        L
Sbjct: 2   VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61

Query: 735 DVSYNNIS--MIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPE 792
           D++YNN+S   +P     L  L+ L+++ N  +ILP  + K  KL+ L+L  N + SLP+
Sbjct: 62  DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121

Query: 793 KVGQLSQLTQLELKGNCLDRLPAQLG 818
           ++G+L+QL +L ++GN L  LP +LG
Sbjct: 122 EIGELTQLKELHIQGNRLTVLPPELG 147



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 48/148 (32%), Positives = 81/148 (54%), Gaps = 4/148 (2%)

Query: 626 LVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRL 685
           +V  ++ ++ N+  L   N ++E +P  I SL  L+ L+L  N + T+     F  L  L
Sbjct: 1   MVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPR--GFGSLPAL 58

Query: 686 TCLKLWHNKIV--TIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISM 743
             L L +N +   ++P +  ++  L +LY S+N  E LP  +  L KL+ L +  N++  
Sbjct: 59  EVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLIS 118

Query: 744 IPIEIGLLQNLQHLHITGNKVDILPKQL 771
           +P EIG L  L+ LHI GN++ +LP +L
Sbjct: 119 LPKEIGELTQLKELHIQGNRLTVLPPEL 146



 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 52/158 (32%), Positives = 83/158 (52%), Gaps = 4/158 (2%)

Query: 650 IPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLE 709
           +P  I  L NL+ L+  +N I  +   IS   L++L  L L  N++ T+P     +  LE
Sbjct: 2   VPPNIAELKNLEVLNFFNNQIEELPTQIS--SLQKLKHLNLGMNRLNTLPRGFGSLPALE 59

Query: 710 SLYFSNNKLE--SLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDIL 767
            L  + N L   SLP   F L  LR L +S N+  ++P +IG L  LQ L +  N +  L
Sbjct: 60  VLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISL 119

Query: 768 PKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLEL 805
           PK++ +  +L+ L++  N +T LP ++G L    Q ++
Sbjct: 120 PKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQV 157



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 35/102 (34%), Positives = 54/102 (52%), Gaps = 4/102 (3%)

Query: 743 MIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQ 802
           M+P  I  L+NL+ L+   N+++ LP Q+    KL+ LNLG N + +LP   G L  L  
Sbjct: 1   MVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEV 60

Query: 803 LELKGNCL--DRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEV 842
           L+L  N L  + LP        L+   L + D+ F+ LP ++
Sbjct: 61  LDLTYNNLSENSLPGNFFYLTTLR--ALYLSDNDFEILPPDI 100


>gi|33285015 leucine rich repeat containing 28 [Homo sapiens]
          Length = 367

 Score = 90.9 bits (224), Expect = 5e-18
 Identities = 66/205 (32%), Positives = 108/205 (52%), Gaps = 10/205 (4%)

Query: 629 NSLKKMMNVAELE------LQNCELERIPHAIFSLSNLQELD---LKSNNIRTIEEIISF 679
           + L K ++VA LE      L    L   P  +     LQ L+   +K N++ ++ E ++ 
Sbjct: 3   SELCKTISVARLEKHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLA- 61

Query: 680 QHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYN 739
           Q L  L  L L  N IV +P +I  +  L+ L  S+N LE +   +  L+ LR L ++ N
Sbjct: 62  QKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANN 121

Query: 740 NISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQ 799
            +  +P E+G L+ LQ L I+ N++  LP++L  C+ L+ L + +N +  +P  + QL  
Sbjct: 122 QLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPS 181

Query: 800 LTQLELKGNCLDRLPAQLGQCRMLK 824
           L +L + GN L  LP  LG+ R L+
Sbjct: 182 LNELSMAGNRLAFLPLDLGRSRELQ 206



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 53/162 (32%), Positives = 87/162 (53%), Gaps = 3/162 (1%)

Query: 657 LSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNN 716
           L NL EL L SNNI  + E I    L +L CL L  N +  + P I  ++ L  L  +NN
Sbjct: 64  LPNLVELYLHSNNIVVVPEAIG--SLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANN 121

Query: 717 KLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIK 776
           +L+ LP  V  L++L+ LD+S N +  +P  + +  +LQ+L +  N++  +P+ L +   
Sbjct: 122 QLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPS 181

Query: 777 LRTLNLGQNCITSLPEKVGQLSQLTQLELKGNC-LDRLPAQL 817
           L  L++  N +  LP  +G+  +L  + +  N  L  LP+ L
Sbjct: 182 LNELSMAGNRLAFLPLDLGRSRELQYVYVDNNIHLKGLPSYL 223



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 61/218 (27%), Positives = 105/218 (48%), Gaps = 29/218 (13%)

Query: 571 LNSENNKMIGLESLRE--LRHLKILHVKSN-LTKVPSNITDVAPHLTKLVIHNDGTKLLV 627
           LN  N     LE L++  L++L+ L++K N LT +P N+    P+L +L +H++   +  
Sbjct: 22  LNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVV-- 79

Query: 628 LNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTC 687
                                 +P AI SL  LQ LDL  N +  +   I    L+ L  
Sbjct: 80  ----------------------VPEAIGSLVKLQCLDLSDNALEIVCPEIG--RLRALRH 115

Query: 688 LKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIE 747
           L+L +N++  +PP +  +K L++L  S N+L +LP  +     L+ L V  N +  +P  
Sbjct: 116 LRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRH 175

Query: 748 IGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQN 785
           +  L +L  L + GN++  LP  L +  +L+ + +  N
Sbjct: 176 LCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDNN 213


>gi|21389431 leucine rich repeat containing 39 [Homo sapiens]
          Length = 335

 Score = 90.5 bits (223), Expect = 6e-18
 Identities = 77/247 (31%), Positives = 124/247 (50%), Gaps = 7/247 (2%)

Query: 581 LESLRELRH--LKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVA 638
           L+  +E +H  ++I   + +LTK+   +T     +  L I  +  K L  +SL K+  + 
Sbjct: 29  LKREKEFQHKLVRIWEERVSLTKLREKVTREDGRVI-LKIEKEEWKTLP-SSLLKLNQLQ 86

Query: 639 ELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTI 698
           E +L    L +IP  I    NL  LDL  N I  I   I    L RL  L L +NKI T+
Sbjct: 87  EWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGL--LTRLQELILSYNKIKTV 144

Query: 699 PPSITHVKNLESLYFSNNK-LESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHL 757
           P  +++  +LE L  + N+ +  LP  + +L KL  LD+S N+ + IP+ +  +  L+ L
Sbjct: 145 PKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWL 204

Query: 758 HITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQL 817
            +  NK++ LP  + +   L TL L +N IT LP+ +  +  L  L L  N L  +P  +
Sbjct: 205 DMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCM 264

Query: 818 GQCRMLK 824
            +   L+
Sbjct: 265 EEMANLR 271



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 58/216 (26%), Positives = 105/216 (48%), Gaps = 5/216 (2%)

Query: 596 KSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIF 655
           K     +PS++  +   L +  +H  G  L +   + +  N+  L+L    +  IP  I 
Sbjct: 69  KEEWKTLPSSLLKLN-QLQEWQLHRTGL-LKIPEFIGRFQNLIVLDLSRNTISEIPPGIG 126

Query: 656 SLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNK-IVTIPPSITHVKNLESLYFS 714
            L+ LQEL L  N I+T+ + +S  +   L  L+L  N+ I  +P  ++++  L  L  S
Sbjct: 127 LLTRLQELILSYNKIKTVPKELS--NCASLEKLELAVNRDICDLPQELSNLLKLTHLDLS 184

Query: 715 NNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKC 774
            N   ++P+AV ++  L  LD+  N +  +P  I  +QNL  L +  N++  LP+ +   
Sbjct: 185 MNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNM 244

Query: 775 IKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCL 810
             L TL L  N +  +P  + +++ L  +  + N L
Sbjct: 245 KNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPL 280



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 64/277 (23%), Positives = 106/277 (38%), Gaps = 77/277 (27%)

Query: 467 NAQDKQELHLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAK 526
           N   + +LH   L  +P+ +    +L VL L     ++IP  I  +T LQEL L +   K
Sbjct: 83  NQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIK 142

Query: 527 VEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRE 586
                 S      +       D+ ++P                           L +L +
Sbjct: 143 TVPKELSNCASLEKLELAVNRDICDLPQ-------------------------ELSNLLK 177

Query: 587 LRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCE 646
           L HL +    ++ T +P                     L VLN    M  +  L++ + +
Sbjct: 178 LTHLDL--SMNDFTTIP---------------------LAVLN----MPALEWLDMGSNK 210

Query: 647 LERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVK 706
           LE++P  I  + NL  L L+ N I               TCL          P +I+++K
Sbjct: 211 LEQLPDTIERMQNLHTLWLQRNEI---------------TCL----------PQTISNMK 245

Query: 707 NLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISM 743
           NL +L  SNNKL+ +PV +  +  LR ++   N + +
Sbjct: 246 NLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKL 282



 Score = 35.8 bits (81), Expect = 0.17
 Identities = 24/93 (25%), Positives = 44/93 (47%), Gaps = 11/93 (11%)

Query: 767 LPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKS 826
           LP  L K  +L+   L +  +  +PE +G+   L  L+L  N +  +P  +G    L++ 
Sbjct: 75  LPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQE- 133

Query: 827 GLVVEDHLFDTLPLEVKE---------ALNQDI 850
            L++  +   T+P E+           A+N+DI
Sbjct: 134 -LILSYNKIKTVPKELSNCASLEKLELAVNRDI 165


>gi|61742786 leucine rich repeat and death domain containing protein
           isoform 3 [Homo sapiens]
          Length = 893

 Score = 90.1 bits (222), Expect = 8e-18
 Identities = 57/181 (31%), Positives = 98/181 (54%), Gaps = 2/181 (1%)

Query: 647 LERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVK 706
           L  +P  +  L++L  LDL  N++ T+   +    ++ L  L L HN +  +P ++  + 
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVL--QMRGLGALLLSHNCLSELPEALGALP 171

Query: 707 NLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDI 766
            L  L  ++N+L++LP A+ +L  L+ LD+S N +  +P EIG L +L  L++  N++  
Sbjct: 172 ALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQS 231

Query: 767 LPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKS 826
           LP  L     LR L L  N + S+P  + +L  LT+L+L+ N L  LP +L     ++  
Sbjct: 232 LPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVRLQ 291

Query: 827 G 827
           G
Sbjct: 292 G 292



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 54/164 (32%), Positives = 83/164 (50%), Gaps = 2/164 (1%)

Query: 682 LKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNI 741
           L  L  L L  N + T+P  +  ++ L +L  S+N L  LP A+ +L  L  L V++N +
Sbjct: 124 LAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRL 183

Query: 742 SMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLT 801
             +P  +G L  LQ L ++ N +D LP ++     L  LNL  N + SLP  +  L  L 
Sbjct: 184 QTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLR 243

Query: 802 QLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEVKEA 845
            L L  N L  +PA L +  +L +  L + D+    LP E+ +A
Sbjct: 244 LLVLHSNLLASVPADLARLPLLTR--LDLRDNQLRDLPPELLDA 285



 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 49/148 (33%), Positives = 80/148 (54%), Gaps = 2/148 (1%)

Query: 695 IVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNL 754
           +  +P  ++ + +L  L  S N LE+LP  V  ++ L  L +S+N +S +P  +G L  L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173

Query: 755 QHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLP 814
             L +T N++  LP  L     L+ L+L QN + +LP ++G L  L +L L  N L  LP
Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233

Query: 815 AQLGQCRMLKKSGLVVEDHLFDTLPLEV 842
           A L   R L+   LV+  +L  ++P ++
Sbjct: 234 ASLAGLRSLRL--LVLHSNLLASVPADL 259



 Score = 50.1 bits (118), Expect = 9e-06
 Identities = 59/250 (23%), Positives = 95/250 (38%), Gaps = 81/250 (32%)

Query: 538 HLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKS 597
           HL  L + F  +  +PA V  ++ L  L L  N  SE  + +G                 
Sbjct: 126 HLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALG----------------- 168

Query: 598 NLTKVPSNITDVAPHLTKL-VIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFS 656
                        P LT L V HN                          L+ +P A+ +
Sbjct: 169 -----------ALPALTFLTVTHN-------------------------RLQTLPPALGA 192

Query: 657 LSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNN 716
           LS LQ LDL  N                          + T+PP I  + +L  L  ++N
Sbjct: 193 LSTLQRLDLSQN-------------------------LLDTLPPEIGGLGSLLELNLASN 227

Query: 717 KLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKC-- 774
           +L+SLP ++  L+ LR L +  N ++ +P ++  L  L  L +  N++  LP +L     
Sbjct: 228 RLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPF 287

Query: 775 IKLRTLNLGQ 784
           ++L+   LG+
Sbjct: 288 VRLQGNPLGE 297



 Score = 30.8 bits (68), Expect = 5.6
 Identities = 60/228 (26%), Positives = 98/228 (42%), Gaps = 29/228 (12%)

Query: 419 LLHM-VDQYDQLYSKRFGVFLSEVSENKLREISLNH-EWTFEKLRQHISRNAQDKQELHL 476
           LLH+ V Q  QL    F + LS   + +L E +L     +   LR  + +  Q +  L  
Sbjct: 50  LLHLCVQQPLQLLQVEF-LRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGA 108

Query: 477 FM---LSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCH-CPAKVEQTAF 532
            +   L+ +P  +  L  L  L L       +PA + QM  L  L L H C +++ +   
Sbjct: 109 CLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALG 168

Query: 533 SFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGN-----------------LNSEN 575
           +     L  L V    +  +P  +  L  L+ L L  N                 LN  +
Sbjct: 169 AL--PALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLAS 226

Query: 576 NKMIGL-ESLRELRHLKILHVKSN-LTKVPSNITDVAPHLTKLVIHND 621
           N++  L  SL  LR L++L + SN L  VP+++  + P LT+L + ++
Sbjct: 227 NRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARL-PLLTRLDLRDN 273


>gi|61742784 leucine rich repeat and death domain containing protein
           isoform 1 [Homo sapiens]
          Length = 910

 Score = 90.1 bits (222), Expect = 8e-18
 Identities = 57/181 (31%), Positives = 98/181 (54%), Gaps = 2/181 (1%)

Query: 647 LERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVK 706
           L  +P  +  L++L  LDL  N++ T+   +    ++ L  L L HN +  +P ++  + 
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVL--QMRGLGALLLSHNCLSELPEALGALP 171

Query: 707 NLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDI 766
            L  L  ++N+L++LP A+ +L  L+ LD+S N +  +P EIG L +L  L++  N++  
Sbjct: 172 ALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQS 231

Query: 767 LPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKS 826
           LP  L     LR L L  N + S+P  + +L  LT+L+L+ N L  LP +L     ++  
Sbjct: 232 LPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVRLQ 291

Query: 827 G 827
           G
Sbjct: 292 G 292



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 54/164 (32%), Positives = 83/164 (50%), Gaps = 2/164 (1%)

Query: 682 LKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNI 741
           L  L  L L  N + T+P  +  ++ L +L  S+N L  LP A+ +L  L  L V++N +
Sbjct: 124 LAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRL 183

Query: 742 SMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLT 801
             +P  +G L  LQ L ++ N +D LP ++     L  LNL  N + SLP  +  L  L 
Sbjct: 184 QTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLR 243

Query: 802 QLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEVKEA 845
            L L  N L  +PA L +  +L +  L + D+    LP E+ +A
Sbjct: 244 LLVLHSNLLASVPADLARLPLLTR--LDLRDNQLRDLPPELLDA 285



 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 49/148 (33%), Positives = 80/148 (54%), Gaps = 2/148 (1%)

Query: 695 IVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNL 754
           +  +P  ++ + +L  L  S N LE+LP  V  ++ L  L +S+N +S +P  +G L  L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173

Query: 755 QHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLP 814
             L +T N++  LP  L     L+ L+L QN + +LP ++G L  L +L L  N L  LP
Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233

Query: 815 AQLGQCRMLKKSGLVVEDHLFDTLPLEV 842
           A L   R L+   LV+  +L  ++P ++
Sbjct: 234 ASLAGLRSLRL--LVLHSNLLASVPADL 259



 Score = 50.1 bits (118), Expect = 9e-06
 Identities = 59/250 (23%), Positives = 95/250 (38%), Gaps = 81/250 (32%)

Query: 538 HLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKS 597
           HL  L + F  +  +PA V  ++ L  L L  N  SE  + +G                 
Sbjct: 126 HLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALG----------------- 168

Query: 598 NLTKVPSNITDVAPHLTKL-VIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFS 656
                        P LT L V HN                          L+ +P A+ +
Sbjct: 169 -----------ALPALTFLTVTHN-------------------------RLQTLPPALGA 192

Query: 657 LSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNN 716
           LS LQ LDL  N                          + T+PP I  + +L  L  ++N
Sbjct: 193 LSTLQRLDLSQN-------------------------LLDTLPPEIGGLGSLLELNLASN 227

Query: 717 KLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKC-- 774
           +L+SLP ++  L+ LR L +  N ++ +P ++  L  L  L +  N++  LP +L     
Sbjct: 228 RLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPF 287

Query: 775 IKLRTLNLGQ 784
           ++L+   LG+
Sbjct: 288 VRLQGNPLGE 297



 Score = 30.8 bits (68), Expect = 5.6
 Identities = 60/228 (26%), Positives = 98/228 (42%), Gaps = 29/228 (12%)

Query: 419 LLHM-VDQYDQLYSKRFGVFLSEVSENKLREISLNH-EWTFEKLRQHISRNAQDKQELHL 476
           LLH+ V Q  QL    F + LS   + +L E +L     +   LR  + +  Q +  L  
Sbjct: 50  LLHLCVQQPLQLLQVEF-LRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGA 108

Query: 477 FM---LSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCH-CPAKVEQTAF 532
            +   L+ +P  +  L  L  L L       +PA + QM  L  L L H C +++ +   
Sbjct: 109 CLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALG 168

Query: 533 SFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGN-----------------LNSEN 575
           +     L  L V    +  +P  +  L  L+ L L  N                 LN  +
Sbjct: 169 AL--PALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLAS 226

Query: 576 NKMIGL-ESLRELRHLKILHVKSN-LTKVPSNITDVAPHLTKLVIHND 621
           N++  L  SL  LR L++L + SN L  VP+++  + P LT+L + ++
Sbjct: 227 NRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARL-PLLTRLDLRDN 273


>gi|154091020 leucine-rich repeats and calponin homology (CH) domain
           containing 2 [Homo sapiens]
          Length = 765

 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 60/175 (34%), Positives = 94/175 (53%), Gaps = 4/175 (2%)

Query: 640 LELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIP 699
           L L   +L   P + + L++  + DL  N    I   +       L  L L+HN I TIP
Sbjct: 93  LSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWL--FAPLETLNLYHNCIKTIP 150

Query: 700 PSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHI 759
            +I +++ L  L  S N L +LP  +F L  L+ L VS N +  IP EIG L++L  L I
Sbjct: 151 EAIKNLQMLTYLNISRNLLSTLPKYLFDLP-LKVLVVSNNKLVSIPEEIGKLKDLMELDI 209

Query: 760 TGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLP 814
           + N++ +LP+Q+ K   LR LN+ +N +  LP+++G L  L +L+   N +  +P
Sbjct: 210 SCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDL-PLVKLDFSCNKVTEIP 263



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 58/184 (31%), Positives = 98/184 (53%), Gaps = 4/184 (2%)

Query: 634 MMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHN 693
           + +  + +L       IP  ++  + L+ L+L  N I+TI E I  ++L+ LT L +  N
Sbjct: 110 LTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEAI--KNLQMLTYLNISRN 167

Query: 694 KIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQN 753
            + T+P  +  +  L+ L  SNNKL S+P  +  L+ L  LD+S N I ++P ++G L +
Sbjct: 168 LLSTLPKYLFDLP-LKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHS 226

Query: 754 LQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRL 813
           L+ L+I  N + +LP +L   + L  L+   N +T +P    +L  L  + L  N L   
Sbjct: 227 LRELNIRRNNLHVLPDELGD-LPLVKLDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVP 285

Query: 814 PAQL 817
           PAQ+
Sbjct: 286 PAQI 289



 Score = 70.1 bits (170), Expect = 8e-12
 Identities = 50/172 (29%), Positives = 86/172 (50%), Gaps = 7/172 (4%)

Query: 688 LKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIE 747
           L L   K+   P S   + +      S N+   +P  V+    L  L++ +N I  IP  
Sbjct: 93  LSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEA 152

Query: 748 IGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKG 807
           I  LQ L +L+I+ N +  LPK LF  + L+ L +  N + S+PE++G+L  L +L++  
Sbjct: 153 IKNLQMLTYLNISRNLLSTLPKYLFD-LPLKVLVVSNNKLVSIPEEIGKLKDLMELDISC 211

Query: 808 NCLDRLPAQLGQCRMLKKSGL------VVEDHLFDTLPLEVKEALNQDINIP 853
           N +  LP Q+G+   L++  +      V+ D L D   +++  + N+   IP
Sbjct: 212 NEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLPLVKLDFSCNKVTEIP 263



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 48/181 (26%), Positives = 87/181 (48%), Gaps = 8/181 (4%)

Query: 596 KSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIF 655
           ++  T++PS++   AP  T  + HN      +  ++K +  +  L +    L  +P  +F
Sbjct: 120 RNRFTEIPSDVWLFAPLETLNLYHN--CIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLF 177

Query: 656 SLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSN 715
            L  L+ L + +N + +I E I    LK L  L +  N+I  +P  +  + +L  L    
Sbjct: 178 DLP-LKVLVVSNNKLVSIPEEIG--KLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRR 234

Query: 716 NKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCI 775
           N L  LP  +  L  ++ LD S N ++ IP+    L +LQ + +  N + + P Q+  C+
Sbjct: 235 NNLHVLPDELGDLPLVK-LDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQI--CL 291

Query: 776 K 776
           K
Sbjct: 292 K 292



 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 43/178 (24%), Positives = 90/178 (50%), Gaps = 16/178 (8%)

Query: 551 EIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNL-TKVPSNITDV 609
           EIP+ V+L   L  L L  N      K I  E+++ L+ L  L++  NL + +P  + D+
Sbjct: 125 EIPSDVWLFAPLETLNLYHNCI----KTIP-EAIKNLQMLTYLNISRNLLSTLPKYLFDL 179

Query: 610 APHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNN 669
                K+++ ++   + +   + K+ ++ EL++   E++ +P  +  L +L+EL+++ NN
Sbjct: 180 P---LKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNN 236

Query: 670 IRTIEEIISFQHLKRL--TCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAV 725
           +  + + +    L +L  +C     NK+  IP     + +L+ +   NN L+  P  +
Sbjct: 237 LHVLPDELGDLPLVKLDFSC-----NKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQI 289


>gi|30181233 leucine-rich repeats and calponin homology (CH) domain
           containing 4 [Homo sapiens]
          Length = 683

 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 62/216 (28%), Positives = 110/216 (50%), Gaps = 9/216 (4%)

Query: 630 SLKKMMNVAELELQNCELERIPHAI---FSLSNLQELDLKSNNIRTIEEIISFQHLKRLT 686
           +L++ +    L L N  L+  P      + LS++ + DL  N    + E      L  L 
Sbjct: 37  ALEEAVATGTLNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAAC--QLVSLE 94

Query: 687 CLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPI 746
            L L+HN +  + P++ ++  L  L  S N+L  LP  +  L  LR L VS N +  +P 
Sbjct: 95  GLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYICQLP-LRVLIVSNNKLGALPP 153

Query: 747 EIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELK 806
           +IG L +L+ L ++ N++  LP +L     LR LN+ +N +++LPE++G L  L +L+  
Sbjct: 154 DIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDL-PLVRLDFS 212

Query: 807 GNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEV 842
            N + R+P     CR+     ++++ +   + P +V
Sbjct: 213 CNRVSRIPVSF--CRLRHLQVILLDSNPLQSPPAQV 246



 Score = 31.6 bits (70), Expect = 3.3
 Identities = 39/146 (26%), Positives = 66/146 (45%), Gaps = 29/146 (19%)

Query: 487 FDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCH-C-----PAKVEQTAFSFL----- 535
           +DL+D+    L      ++P    Q+ +L+ L L H C     PA    TA ++L     
Sbjct: 65  YDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRN 124

Query: 536 ----------RDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGN-LNSENNKMIGLESL 584
                     +  LR L V    +  +P  +  L +LR+L +  N L S  +++ GL SL
Sbjct: 125 QLSLLPPYICQLPLRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSL 184

Query: 585 RELRHLKILHVKSN-LTKVPSNITDV 609
           R+      L+V+ N L+ +P  + D+
Sbjct: 185 RD------LNVRRNQLSTLPEELGDL 204


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.136    0.405 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,755,988
Number of Sequences: 37866
Number of extensions: 1350626
Number of successful extensions: 5861
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 113
Number of HSP's successfully gapped in prelim test: 165
Number of HSP's that attempted gapping in prelim test: 4033
Number of HSP's gapped (non-prelim): 854
length of query: 858
length of database: 18,247,518
effective HSP length: 111
effective length of query: 747
effective length of database: 14,044,392
effective search space: 10491160824
effective search space used: 10491160824
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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