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Search of human proteins with 197333692
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|197333692 leucine rich repeat containing 8 family, member B
[Homo sapiens]
(803 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|197333692 leucine rich repeat containing 8 family, member B [... 1609 0.0
gi|21245134 leucine rich repeat containing 8 family, member B [H... 1609 0.0
gi|62241040 leucine rich repeat containing 8 family, member A [H... 956 0.0
gi|187829877 leucine rich repeat containing 8 family, member A [... 956 0.0
gi|187829871 leucine rich repeat containing 8 family, member A [... 956 0.0
gi|19923729 leucine rich repeat containing 8 family, member C [H... 831 0.0
gi|197333706 leucine rich repeat containing 8 family, member D [... 769 0.0
gi|34222199 leucine rich repeat containing 8 family, member D [H... 769 0.0
gi|40217803 leucine rich repeat containing 8 family, member E [H... 738 0.0
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 123 8e-28
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens] 123 8e-28
gi|95113664 leucine rich repeat containing 1 [Homo sapiens] 123 8e-28
gi|45827729 scribble isoform b [Homo sapiens] 119 1e-26
gi|45827731 scribble isoform a [Homo sapiens] 119 1e-26
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 115 1e-25
gi|238908508 leucine-rich repeat and death domain-containing pro... 115 2e-25
gi|4503743 flightless I homolog [Homo sapiens] 112 1e-24
gi|16904383 leucine rich repeat containing 7 [Homo sapiens] 107 4e-23
gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom... 102 2e-21
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 100 4e-21
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 97 5e-20
gi|61742786 leucine rich repeat and death domain containing prot... 96 2e-19
gi|61742784 leucine rich repeat and death domain containing prot... 96 2e-19
gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens] 93 1e-18
gi|34577083 ras suppressor protein 1 isoform 2 [Homo sapiens] 93 1e-18
gi|193788651 leucine rich repeat containing 69 [Homo sapiens] 88 3e-17
gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 87 5e-17
gi|33285015 leucine rich repeat containing 28 [Homo sapiens] 87 5e-17
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 87 6e-17
gi|21389431 leucine rich repeat containing 39 [Homo sapiens] 86 1e-16
>gi|197333692 leucine rich repeat containing 8 family, member B
[Homo sapiens]
Length = 803
Score = 1609 bits (4166), Expect = 0.0
Identities = 803/803 (100%), Positives = 803/803 (100%)
Query: 1 MITLTELKCLADAQSSYHILKPWWDVFWYYITLIMLLVAVLAGALQLTQSRVLCCLPCKV 60
MITLTELKCLADAQSSYHILKPWWDVFWYYITLIMLLVAVLAGALQLTQSRVLCCLPCKV
Sbjct: 1 MITLTELKCLADAQSSYHILKPWWDVFWYYITLIMLLVAVLAGALQLTQSRVLCCLPCKV 60
Query: 61 EFDNHCAVPWDILKASMNTSSNPGTPLPLPLRIQNDLHRQQYSYIDAVCYEKQLHWFAKF 120
EFDNHCAVPWDILKASMNTSSNPGTPLPLPLRIQNDLHRQQYSYIDAVCYEKQLHWFAKF
Sbjct: 61 EFDNHCAVPWDILKASMNTSSNPGTPLPLPLRIQNDLHRQQYSYIDAVCYEKQLHWFAKF 120
Query: 121 FPYLVLLHTLIFAACSNFWLHYPSTSSRLEHFVAILHKCFDSPWTTRALSETVAEQSVRP 180
FPYLVLLHTLIFAACSNFWLHYPSTSSRLEHFVAILHKCFDSPWTTRALSETVAEQSVRP
Sbjct: 121 FPYLVLLHTLIFAACSNFWLHYPSTSSRLEHFVAILHKCFDSPWTTRALSETVAEQSVRP 180
Query: 181 LKLSKSKILLSSSGCSADIDSGKQSLPYPQPGLESAGIESPTSSVLDKKEGEQAKAIFEK 240
LKLSKSKILLSSSGCSADIDSGKQSLPYPQPGLESAGIESPTSSVLDKKEGEQAKAIFEK
Sbjct: 181 LKLSKSKILLSSSGCSADIDSGKQSLPYPQPGLESAGIESPTSSVLDKKEGEQAKAIFEK 240
Query: 241 VKRFRMHVEQKDIIYRVYLKQIIVKVILFVLIITYVPYFLTHITLEIDCSVDVQAFTGYK 300
VKRFRMHVEQKDIIYRVYLKQIIVKVILFVLIITYVPYFLTHITLEIDCSVDVQAFTGYK
Sbjct: 241 VKRFRMHVEQKDIIYRVYLKQIIVKVILFVLIITYVPYFLTHITLEIDCSVDVQAFTGYK 300
Query: 301 RYQCVYSLAEIFKVLASFYVILVILYGLTSSYSLWWMLRSSLKQYSFEALREKSNYSDIP 360
RYQCVYSLAEIFKVLASFYVILVILYGLTSSYSLWWMLRSSLKQYSFEALREKSNYSDIP
Sbjct: 301 RYQCVYSLAEIFKVLASFYVILVILYGLTSSYSLWWMLRSSLKQYSFEALREKSNYSDIP 360
Query: 361 DVKNDFAFILHLADQYDPLYSKRFSIFLSEVSENKLKQINLNNEWTVEKLKSKLVKNAQD 420
DVKNDFAFILHLADQYDPLYSKRFSIFLSEVSENKLKQINLNNEWTVEKLKSKLVKNAQD
Sbjct: 361 DVKNDFAFILHLADQYDPLYSKRFSIFLSEVSENKLKQINLNNEWTVEKLKSKLVKNAQD 420
Query: 421 KIELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHP 480
KIELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHP
Sbjct: 421 KIELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHP 480
Query: 481 ALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNL 540
ALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNL
Sbjct: 481 ALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNL 540
Query: 541 RTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERI 600
RTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERI
Sbjct: 541 RTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERI 600
Query: 601 PHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQ 660
PHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQ
Sbjct: 601 PHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQ 660
Query: 661 LSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDG 720
LSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDG
Sbjct: 661 LSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDG 720
Query: 721 LFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIV 780
LFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIV
Sbjct: 721 LFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIV 780
Query: 781 EENLLNTLPLPVTERLQTCLDKC 803
EENLLNTLPLPVTERLQTCLDKC
Sbjct: 781 EENLLNTLPLPVTERLQTCLDKC 803
>gi|21245134 leucine rich repeat containing 8 family, member B [Homo
sapiens]
Length = 803
Score = 1609 bits (4166), Expect = 0.0
Identities = 803/803 (100%), Positives = 803/803 (100%)
Query: 1 MITLTELKCLADAQSSYHILKPWWDVFWYYITLIMLLVAVLAGALQLTQSRVLCCLPCKV 60
MITLTELKCLADAQSSYHILKPWWDVFWYYITLIMLLVAVLAGALQLTQSRVLCCLPCKV
Sbjct: 1 MITLTELKCLADAQSSYHILKPWWDVFWYYITLIMLLVAVLAGALQLTQSRVLCCLPCKV 60
Query: 61 EFDNHCAVPWDILKASMNTSSNPGTPLPLPLRIQNDLHRQQYSYIDAVCYEKQLHWFAKF 120
EFDNHCAVPWDILKASMNTSSNPGTPLPLPLRIQNDLHRQQYSYIDAVCYEKQLHWFAKF
Sbjct: 61 EFDNHCAVPWDILKASMNTSSNPGTPLPLPLRIQNDLHRQQYSYIDAVCYEKQLHWFAKF 120
Query: 121 FPYLVLLHTLIFAACSNFWLHYPSTSSRLEHFVAILHKCFDSPWTTRALSETVAEQSVRP 180
FPYLVLLHTLIFAACSNFWLHYPSTSSRLEHFVAILHKCFDSPWTTRALSETVAEQSVRP
Sbjct: 121 FPYLVLLHTLIFAACSNFWLHYPSTSSRLEHFVAILHKCFDSPWTTRALSETVAEQSVRP 180
Query: 181 LKLSKSKILLSSSGCSADIDSGKQSLPYPQPGLESAGIESPTSSVLDKKEGEQAKAIFEK 240
LKLSKSKILLSSSGCSADIDSGKQSLPYPQPGLESAGIESPTSSVLDKKEGEQAKAIFEK
Sbjct: 181 LKLSKSKILLSSSGCSADIDSGKQSLPYPQPGLESAGIESPTSSVLDKKEGEQAKAIFEK 240
Query: 241 VKRFRMHVEQKDIIYRVYLKQIIVKVILFVLIITYVPYFLTHITLEIDCSVDVQAFTGYK 300
VKRFRMHVEQKDIIYRVYLKQIIVKVILFVLIITYVPYFLTHITLEIDCSVDVQAFTGYK
Sbjct: 241 VKRFRMHVEQKDIIYRVYLKQIIVKVILFVLIITYVPYFLTHITLEIDCSVDVQAFTGYK 300
Query: 301 RYQCVYSLAEIFKVLASFYVILVILYGLTSSYSLWWMLRSSLKQYSFEALREKSNYSDIP 360
RYQCVYSLAEIFKVLASFYVILVILYGLTSSYSLWWMLRSSLKQYSFEALREKSNYSDIP
Sbjct: 301 RYQCVYSLAEIFKVLASFYVILVILYGLTSSYSLWWMLRSSLKQYSFEALREKSNYSDIP 360
Query: 361 DVKNDFAFILHLADQYDPLYSKRFSIFLSEVSENKLKQINLNNEWTVEKLKSKLVKNAQD 420
DVKNDFAFILHLADQYDPLYSKRFSIFLSEVSENKLKQINLNNEWTVEKLKSKLVKNAQD
Sbjct: 361 DVKNDFAFILHLADQYDPLYSKRFSIFLSEVSENKLKQINLNNEWTVEKLKSKLVKNAQD 420
Query: 421 KIELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHP 480
KIELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHP
Sbjct: 421 KIELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHP 480
Query: 481 ALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNL 540
ALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNL
Sbjct: 481 ALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNL 540
Query: 541 RTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERI 600
RTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERI
Sbjct: 541 RTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERI 600
Query: 601 PHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQ 660
PHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQ
Sbjct: 601 PHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQ 660
Query: 661 LSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDG 720
LSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDG
Sbjct: 661 LSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDG 720
Query: 721 LFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIV 780
LFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIV
Sbjct: 721 LFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIV 780
Query: 781 EENLLNTLPLPVTERLQTCLDKC 803
EENLLNTLPLPVTERLQTCLDKC
Sbjct: 781 EENLLNTLPLPVTERLQTCLDKC 803
>gi|62241040 leucine rich repeat containing 8 family, member A [Homo
sapiens]
Length = 810
Score = 956 bits (2471), Expect = 0.0
Identities = 474/803 (59%), Positives = 612/803 (76%), Gaps = 8/803 (0%)
Query: 1 MITLTELKCLADAQSSYHILKPWWDVFWYYITLIMLLVAVLAGALQLTQSRVLCCLPCKV 60
MI +TEL+ AD Q +Y ILKPWWDVF YI+++ML++AV G LQ+TQ +++C LPCK
Sbjct: 1 MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMIC-LPCKW 59
Query: 61 EFDNHCAVPWDILKASMNTSSNPG-----TPLPLPLRIQNDLHRQQYSYIDAVCYEKQLH 115
+ C + A + P TP P I+ DL R QY+Y+DAVCYE +LH
Sbjct: 60 VTKDSCNDSFRGWAAPGPEPTYPNSTILPTPDTGPTGIKYDLDRHQYNYVDAVCYENRLH 119
Query: 116 WFAKFFPYLVLLHTLIFAACSNFWLHYPSTSSRLEHFVAILHKCFDSPWTTRALSETVAE 175
WFAK+FPYLVLLHTLIF ACSNFW +P TSS+LEHFV+IL KCFDSPWTTRALSETV E
Sbjct: 120 WFAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSETVVE 179
Query: 176 QSVRPLKLSKSKILLS--SSGCSADIDSGKQSLPYPQPGLESAGIESPTSSVLDKKEGEQ 233
+S SK + SS S D+++ L + +E ++ + VLDKKEGEQ
Sbjct: 180 ESDPKPAFSKMNGSMDKKSSTVSEDVEATVPMLQRTKSRIEQGIVDRSETGVLDKKEGEQ 239
Query: 234 AKAIFEKVKRFRMHVEQKDIIYRVYLKQIIVKVILFVLIITYVPYFLTHITLEIDCSVDV 293
AKA+FEKVK+FR HVE+ DI+YR+Y++Q I+KVI F+LII Y Y++ +I ++DC+VD+
Sbjct: 240 AKALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFILIICYTVYYVHNIKFDVDCTVDI 299
Query: 294 QAFTGYKRYQCVYSLAEIFKVLASFYVILVILYGLTSSYSLWWMLRSSLKQYSFEALREK 353
++ TGY+ Y+C + LA +FK+LASFY+ LVI YGL Y+LWWMLR SLK+YSFE++RE+
Sbjct: 300 ESLTGYRTYRCAHPLATLFKILASFYISLVIFYGLICMYTLWWMLRRSLKKYSFESIREE 359
Query: 354 SNYSDIPDVKNDFAFILHLADQYDPLYSKRFSIFLSEVSENKLKQINLNNEWTVEKLKSK 413
S+YSDIPDVKNDFAF+LHL DQYDPLYSKRF++FLSEVSENKL+Q+NLNNEWT++KL+ +
Sbjct: 360 SSYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQR 419
Query: 414 LVKNAQDKIELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHS 473
L KNAQDK+ELHLFML+G+PD VF+L E+EVL LELIP+V +P +++QL LKEL +YH+
Sbjct: 420 LTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHT 479
Query: 474 SLVVDHPALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEG 533
+ ++ PALAFL ENL+ L +KFT++ +IP W++ LK L+EL+L+G + E + ++G
Sbjct: 480 AAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDG 539
Query: 534 FQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELI 593
++LK L+ L LKS+LS++PQVVTD+ LQKLS++NEG+KL+VLN+LKKM NL LELI
Sbjct: 540 LRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELI 599
Query: 594 SCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIG 653
CDLERIPHSIFSL+NL E+DL++NNLKT+EEIISFQHL L+CLKLW+N+IAYIP QIG
Sbjct: 600 RCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIG 659
Query: 654 ALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNN 713
L+NLE+L L+ N IE +P QLF C KL YLDLS+N+LTF+P +I L NLQ A+T N
Sbjct: 660 NLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANR 719
Query: 714 IEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSL 773
IE LP LFQC+KL+ L LG N L +L VGEL+NLT +EL GN LE LP EL C L
Sbjct: 720 IETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLL 779
Query: 774 KRNCLIVEENLLNTLPLPVTERL 796
KR+ L+VEE+L NTLP V ERL
Sbjct: 780 KRSGLVVEEDLFNTLPPEVKERL 802
>gi|187829877 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 956 bits (2471), Expect = 0.0
Identities = 474/803 (59%), Positives = 612/803 (76%), Gaps = 8/803 (0%)
Query: 1 MITLTELKCLADAQSSYHILKPWWDVFWYYITLIMLLVAVLAGALQLTQSRVLCCLPCKV 60
MI +TEL+ AD Q +Y ILKPWWDVF YI+++ML++AV G LQ+TQ +++C LPCK
Sbjct: 1 MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMIC-LPCKW 59
Query: 61 EFDNHCAVPWDILKASMNTSSNPG-----TPLPLPLRIQNDLHRQQYSYIDAVCYEKQLH 115
+ C + A + P TP P I+ DL R QY+Y+DAVCYE +LH
Sbjct: 60 VTKDSCNDSFRGWAAPGPEPTYPNSTILPTPDTGPTGIKYDLDRHQYNYVDAVCYENRLH 119
Query: 116 WFAKFFPYLVLLHTLIFAACSNFWLHYPSTSSRLEHFVAILHKCFDSPWTTRALSETVAE 175
WFAK+FPYLVLLHTLIF ACSNFW +P TSS+LEHFV+IL KCFDSPWTTRALSETV E
Sbjct: 120 WFAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSETVVE 179
Query: 176 QSVRPLKLSKSKILLS--SSGCSADIDSGKQSLPYPQPGLESAGIESPTSSVLDKKEGEQ 233
+S SK + SS S D+++ L + +E ++ + VLDKKEGEQ
Sbjct: 180 ESDPKPAFSKMNGSMDKKSSTVSEDVEATVPMLQRTKSRIEQGIVDRSETGVLDKKEGEQ 239
Query: 234 AKAIFEKVKRFRMHVEQKDIIYRVYLKQIIVKVILFVLIITYVPYFLTHITLEIDCSVDV 293
AKA+FEKVK+FR HVE+ DI+YR+Y++Q I+KVI F+LII Y Y++ +I ++DC+VD+
Sbjct: 240 AKALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFILIICYTVYYVHNIKFDVDCTVDI 299
Query: 294 QAFTGYKRYQCVYSLAEIFKVLASFYVILVILYGLTSSYSLWWMLRSSLKQYSFEALREK 353
++ TGY+ Y+C + LA +FK+LASFY+ LVI YGL Y+LWWMLR SLK+YSFE++RE+
Sbjct: 300 ESLTGYRTYRCAHPLATLFKILASFYISLVIFYGLICMYTLWWMLRRSLKKYSFESIREE 359
Query: 354 SNYSDIPDVKNDFAFILHLADQYDPLYSKRFSIFLSEVSENKLKQINLNNEWTVEKLKSK 413
S+YSDIPDVKNDFAF+LHL DQYDPLYSKRF++FLSEVSENKL+Q+NLNNEWT++KL+ +
Sbjct: 360 SSYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQR 419
Query: 414 LVKNAQDKIELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHS 473
L KNAQDK+ELHLFML+G+PD VF+L E+EVL LELIP+V +P +++QL LKEL +YH+
Sbjct: 420 LTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHT 479
Query: 474 SLVVDHPALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEG 533
+ ++ PALAFL ENL+ L +KFT++ +IP W++ LK L+EL+L+G + E + ++G
Sbjct: 480 AAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDG 539
Query: 534 FQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELI 593
++LK L+ L LKS+LS++PQVVTD+ LQKLS++NEG+KL+VLN+LKKM NL LELI
Sbjct: 540 LRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELI 599
Query: 594 SCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIG 653
CDLERIPHSIFSL+NL E+DL++NNLKT+EEIISFQHL L+CLKLW+N+IAYIP QIG
Sbjct: 600 RCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIG 659
Query: 654 ALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNN 713
L+NLE+L L+ N IE +P QLF C KL YLDLS+N+LTF+P +I L NLQ A+T N
Sbjct: 660 NLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANR 719
Query: 714 IEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSL 773
IE LP LFQC+KL+ L LG N L +L VGEL+NLT +EL GN LE LP EL C L
Sbjct: 720 IETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLL 779
Query: 774 KRNCLIVEENLLNTLPLPVTERL 796
KR+ L+VEE+L NTLP V ERL
Sbjct: 780 KRSGLVVEEDLFNTLPPEVKERL 802
>gi|187829871 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 956 bits (2471), Expect = 0.0
Identities = 474/803 (59%), Positives = 612/803 (76%), Gaps = 8/803 (0%)
Query: 1 MITLTELKCLADAQSSYHILKPWWDVFWYYITLIMLLVAVLAGALQLTQSRVLCCLPCKV 60
MI +TEL+ AD Q +Y ILKPWWDVF YI+++ML++AV G LQ+TQ +++C LPCK
Sbjct: 1 MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMIC-LPCKW 59
Query: 61 EFDNHCAVPWDILKASMNTSSNPG-----TPLPLPLRIQNDLHRQQYSYIDAVCYEKQLH 115
+ C + A + P TP P I+ DL R QY+Y+DAVCYE +LH
Sbjct: 60 VTKDSCNDSFRGWAAPGPEPTYPNSTILPTPDTGPTGIKYDLDRHQYNYVDAVCYENRLH 119
Query: 116 WFAKFFPYLVLLHTLIFAACSNFWLHYPSTSSRLEHFVAILHKCFDSPWTTRALSETVAE 175
WFAK+FPYLVLLHTLIF ACSNFW +P TSS+LEHFV+IL KCFDSPWTTRALSETV E
Sbjct: 120 WFAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSETVVE 179
Query: 176 QSVRPLKLSKSKILLS--SSGCSADIDSGKQSLPYPQPGLESAGIESPTSSVLDKKEGEQ 233
+S SK + SS S D+++ L + +E ++ + VLDKKEGEQ
Sbjct: 180 ESDPKPAFSKMNGSMDKKSSTVSEDVEATVPMLQRTKSRIEQGIVDRSETGVLDKKEGEQ 239
Query: 234 AKAIFEKVKRFRMHVEQKDIIYRVYLKQIIVKVILFVLIITYVPYFLTHITLEIDCSVDV 293
AKA+FEKVK+FR HVE+ DI+YR+Y++Q I+KVI F+LII Y Y++ +I ++DC+VD+
Sbjct: 240 AKALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFILIICYTVYYVHNIKFDVDCTVDI 299
Query: 294 QAFTGYKRYQCVYSLAEIFKVLASFYVILVILYGLTSSYSLWWMLRSSLKQYSFEALREK 353
++ TGY+ Y+C + LA +FK+LASFY+ LVI YGL Y+LWWMLR SLK+YSFE++RE+
Sbjct: 300 ESLTGYRTYRCAHPLATLFKILASFYISLVIFYGLICMYTLWWMLRRSLKKYSFESIREE 359
Query: 354 SNYSDIPDVKNDFAFILHLADQYDPLYSKRFSIFLSEVSENKLKQINLNNEWTVEKLKSK 413
S+YSDIPDVKNDFAF+LHL DQYDPLYSKRF++FLSEVSENKL+Q+NLNNEWT++KL+ +
Sbjct: 360 SSYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQR 419
Query: 414 LVKNAQDKIELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHS 473
L KNAQDK+ELHLFML+G+PD VF+L E+EVL LELIP+V +P +++QL LKEL +YH+
Sbjct: 420 LTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHT 479
Query: 474 SLVVDHPALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEG 533
+ ++ PALAFL ENL+ L +KFT++ +IP W++ LK L+EL+L+G + E + ++G
Sbjct: 480 AAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDG 539
Query: 534 FQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELI 593
++LK L+ L LKS+LS++PQVVTD+ LQKLS++NEG+KL+VLN+LKKM NL LELI
Sbjct: 540 LRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELI 599
Query: 594 SCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIG 653
CDLERIPHSIFSL+NL E+DL++NNLKT+EEIISFQHL L+CLKLW+N+IAYIP QIG
Sbjct: 600 RCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIG 659
Query: 654 ALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNN 713
L+NLE+L L+ N IE +P QLF C KL YLDLS+N+LTF+P +I L NLQ A+T N
Sbjct: 660 NLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANR 719
Query: 714 IEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSL 773
IE LP LFQC+KL+ L LG N L +L VGEL+NLT +EL GN LE LP EL C L
Sbjct: 720 IETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLL 779
Query: 774 KRNCLIVEENLLNTLPLPVTERL 796
KR+ L+VEE+L NTLP V ERL
Sbjct: 780 KRSGLVVEEDLFNTLPPEVKERL 802
>gi|19923729 leucine rich repeat containing 8 family, member C [Homo
sapiens]
Length = 803
Score = 831 bits (2147), Expect = 0.0
Identities = 407/810 (50%), Positives = 584/810 (72%), Gaps = 20/810 (2%)
Query: 1 MITLTELKCLADAQSSYHILKPWWDVFWYYITLIMLLVAVLAGALQLTQSRVLCCLPCKV 60
MI +TE + ++ Q ++ +LKPWWDVF Y+++ ML++ V LQ+ Q +++C LP +V
Sbjct: 1 MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIIC-LPKRV 59
Query: 61 E-FDNHCAVPWDILKASMNTSS------NPGTPLPLPLR-IQNDLHRQQYSYIDAVCYEK 112
+ NH ++ ++ +A +T+ +P P+ + ++ ++ DL QQYS+I+ +CYE+
Sbjct: 60 QPAQNHSSLS-NVSQAVASTTPLPPPKPSPANPITVEMKGLKTDLDLQQYSFINQMCYER 118
Query: 113 QLHWFAKFFPYLVLLHTLIFAACSNFWLHYPSTSSRLEHFVAILHKCFDSPWTTRALSET 172
LHW+AK+FPYLVL+HTL+F CSNFW +P +SS++EHF++IL KCFDSPWTTRALSE
Sbjct: 119 ALHWYAKYFPYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFISILGKCFDSPWTTRALSEV 178
Query: 173 VAEQSV----RPLKLSKSKILLSSSGCSADIDSGKQSLPYPQPGLESAGIESPTSSVLDK 228
E S R +++S + S S +S+P E ++ T+ LDK
Sbjct: 179 SGEDSEEKDNRKNNMNRSNTIQSGPEGSLVNSQSLKSIP------EKFVVDKSTAGALDK 232
Query: 229 KEGEQAKAIFEKVKRFRMHVEQKDIIYRVYLKQIIVKVILFVLIITYVPYFLTHITLEID 288
KEGEQAKA+FEKVK+FR+HVE+ DI+Y +Y++Q ++KVI F++II Y ++ + +D
Sbjct: 233 KEGEQAKALFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVD 292
Query: 289 CSVDVQAFTGYKRYQCVYSLAEIFKVLASFYVILVILYGLTSSYSLWWMLRSSLKQYSFE 348
C+VD+Q TGYK + C +++A +F L+ Y+ V +YGLT Y+L+W+ SL++YSFE
Sbjct: 293 CNVDIQDMTGYKNFSCNHTMAHLFSKLSFCYLCFVSIYGLTCLYTLYWLFYRSLREYSFE 352
Query: 349 ALREKSNYSDIPDVKNDFAFILHLADQYDPLYSKRFSIFLSEVSENKLKQINLNNEWTVE 408
+R+++ DIPDVKNDFAF+LH+ DQYDPLYSKRF++FLSEVSENKLKQ+NLNNEWT +
Sbjct: 353 YVRQETGIDDIPDVKNDFAFMLHMIDQYDPLYSKRFAVFLSEVSENKLKQLNLNNEWTPD 412
Query: 409 KLKSKLVKNAQDKIELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKEL 468
KL+ KL NA +++EL L ML+GLPD VFE+TE++ L LE+I V +P+ ++QL NL+EL
Sbjct: 413 KLRQKLQTNAHNRLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQEL 472
Query: 469 RVYHSSLVVDHPALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLST 528
++ S+ + AL+FL+ENLK+L +KF +M ++P W++ L+NL+ELYL G + +
Sbjct: 473 SLHQCSVKIHSAALSFLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRN 532
Query: 529 MQLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLK 588
+ LE +DLK+L+ L +KS++S+IPQ V D+ LQK+ + N+G+KLV+LNNLKKM NL
Sbjct: 533 VTLESLRDLKSLKILSIKSNVSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLT 592
Query: 589 SLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYI 648
LEL+ CDLERIPH++FSL +L ELDL+ENNLK++EEI+SFQHL+ L+ LKLWHN+I YI
Sbjct: 593 ELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYI 652
Query: 649 PAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFA 708
P I L++LE+LS HN IE LP LFLC K+ YLDLSYN + FIP EI L +LQYF+
Sbjct: 653 PEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFS 712
Query: 709 VTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELE 768
+T N +E LPD L+ CKKL+ L +GKNSL LSP +G L L++L++ GN+ E LPPEL
Sbjct: 713 ITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELG 772
Query: 769 GCQSLKRNCLIVEENLLNTLPLPVTERLQT 798
C++LKR L+VE+ L TLP V E+++T
Sbjct: 773 DCRALKRAGLVVEDALFETLPSDVREQMKT 802
>gi|197333706 leucine rich repeat containing 8 family, member D
[Homo sapiens]
Length = 858
Score = 769 bits (1986), Expect = 0.0
Identities = 393/846 (46%), Positives = 561/846 (66%), Gaps = 50/846 (5%)
Query: 1 MITLTELKCLADAQSSYHILKPWWDVFWYYITLIMLLVAVLAGALQLTQSRVLCC--LPC 58
M TL E+ L D Q +Y ILKPWWDVF Y+ ++ML+VA+ AG +QLT+ +V+C LP
Sbjct: 1 MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPS 60
Query: 59 KVEFDNH-----CAVPWDILKASMNTSSN--------------------------PGTPL 87
V H V +I K T+ + P T
Sbjct: 61 PVNSKAHTPPGNAEVTTNIPKMEAATNQDQDGRTTNDISFGTSAVTPDIPLRATYPRTDF 120
Query: 88 PLPLRI-----------QNDLHRQQYSYIDAVCYEKQLHWFAKFFPYLVLLHTLIFAACS 136
LP + + +L QQY +I+ +CY L W++K+FPYL L+HT+I S
Sbjct: 121 ALPNQEAKKEKKDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSS 180
Query: 137 NFWLHYPSTSSRLEHFVAILHKCFDSPWTTRALSETVAEQSVR-PLKLSKSKILLSSSGC 195
NFW YP T S++EHFV+IL KCF+SPWTT+ALSET E S +++ ++ L
Sbjct: 181 NFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVST 240
Query: 196 SADIDSGKQSLPYPQP-----GLESAGIESPTSSVLDKKEGEQAKAIFEKVKRFRMHVEQ 250
S+D S S P E IE P+ ++LDKK+GEQAKA+FEKV++FR HVE
Sbjct: 241 SSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVED 300
Query: 251 KDIIYRVYLKQIIVKVILFVLIITYVPYFLTHITLEIDCSVDVQAFTGYKRYQCVYSLAE 310
D+IY++Y+ Q ++K F+ I+ Y F+ I+ E C V+ GY+ ++C +++A
Sbjct: 301 SDLIYKLYVVQTVIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMAY 360
Query: 311 IFKVLASFYVILVILYGLTSSYSLWWMLRSSLKQYSFEALREKSNYSDIPDVKNDFAFIL 370
+ K L Y+ ++ +YG Y+L+W+ R LK+YSFE +RE+S++SDIPDVKNDFAF+L
Sbjct: 361 MLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLL 420
Query: 371 HLADQYDPLYSKRFSIFLSEVSENKLKQINLNNEWTVEKLKSKLVKNAQDKIELHLFMLN 430
H+ DQYD LYSKRF +FLSEVSENKL++I+LN+EWT EKL+ + +NAQDK ELHLFML+
Sbjct: 421 HMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLS 480
Query: 431 GLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLK 490
G+PD VF+LT+++VL LELIPE K+P+ +SQ+ NL+EL + H V+ A +FL ++L+
Sbjct: 481 GVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLR 540
Query: 491 ILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSLS 550
L +KFT++ +IP WV+ LKNL+ELYL G + E + LE ++L++L+ L++KS+L+
Sbjct: 541 CLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLT 600
Query: 551 RIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNL 610
++P +TD+ P L KL + N+G+KL+VLN+LKKM+N+ LEL +C+LERIPH+IFSL+NL
Sbjct: 601 KVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNL 660
Query: 611 HELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIEN 670
ELDL+ NN++T+EEIISFQHL+ L+CLKLWHN I IP I + NLE L +N +E+
Sbjct: 661 QELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLES 720
Query: 671 LPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCL 730
LP+ +F KL LD+SYN+++ IP EI L NLQ+ +T N +++LP LF+C KL+ L
Sbjct: 721 LPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTL 780
Query: 731 LLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTLPL 790
LG+N + +L VG+LS LT LEL GN L+ LP +L C+ LK++ L+VE++L +TLPL
Sbjct: 781 NLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPL 840
Query: 791 PVTERL 796
V E L
Sbjct: 841 EVKEAL 846
>gi|34222199 leucine rich repeat containing 8 family, member D [Homo
sapiens]
Length = 858
Score = 769 bits (1986), Expect = 0.0
Identities = 393/846 (46%), Positives = 561/846 (66%), Gaps = 50/846 (5%)
Query: 1 MITLTELKCLADAQSSYHILKPWWDVFWYYITLIMLLVAVLAGALQLTQSRVLCC--LPC 58
M TL E+ L D Q +Y ILKPWWDVF Y+ ++ML+VA+ AG +QLT+ +V+C LP
Sbjct: 1 MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPS 60
Query: 59 KVEFDNH-----CAVPWDILKASMNTSSN--------------------------PGTPL 87
V H V +I K T+ + P T
Sbjct: 61 PVNSKAHTPPGNAEVTTNIPKMEAATNQDQDGRTTNDISFGTSAVTPDIPLRATYPRTDF 120
Query: 88 PLPLRI-----------QNDLHRQQYSYIDAVCYEKQLHWFAKFFPYLVLLHTLIFAACS 136
LP + + +L QQY +I+ +CY L W++K+FPYL L+HT+I S
Sbjct: 121 ALPNQEAKKEKKDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSS 180
Query: 137 NFWLHYPSTSSRLEHFVAILHKCFDSPWTTRALSETVAEQSVR-PLKLSKSKILLSSSGC 195
NFW YP T S++EHFV+IL KCF+SPWTT+ALSET E S +++ ++ L
Sbjct: 181 NFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVST 240
Query: 196 SADIDSGKQSLPYPQP-----GLESAGIESPTSSVLDKKEGEQAKAIFEKVKRFRMHVEQ 250
S+D S S P E IE P+ ++LDKK+GEQAKA+FEKV++FR HVE
Sbjct: 241 SSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVED 300
Query: 251 KDIIYRVYLKQIIVKVILFVLIITYVPYFLTHITLEIDCSVDVQAFTGYKRYQCVYSLAE 310
D+IY++Y+ Q ++K F+ I+ Y F+ I+ E C V+ GY+ ++C +++A
Sbjct: 301 SDLIYKLYVVQTVIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMAY 360
Query: 311 IFKVLASFYVILVILYGLTSSYSLWWMLRSSLKQYSFEALREKSNYSDIPDVKNDFAFIL 370
+ K L Y+ ++ +YG Y+L+W+ R LK+YSFE +RE+S++SDIPDVKNDFAF+L
Sbjct: 361 MLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLL 420
Query: 371 HLADQYDPLYSKRFSIFLSEVSENKLKQINLNNEWTVEKLKSKLVKNAQDKIELHLFMLN 430
H+ DQYD LYSKRF +FLSEVSENKL++I+LN+EWT EKL+ + +NAQDK ELHLFML+
Sbjct: 421 HMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLS 480
Query: 431 GLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLK 490
G+PD VF+LT+++VL LELIPE K+P+ +SQ+ NL+EL + H V+ A +FL ++L+
Sbjct: 481 GVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLR 540
Query: 491 ILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSLS 550
L +KFT++ +IP WV+ LKNL+ELYL G + E + LE ++L++L+ L++KS+L+
Sbjct: 541 CLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLT 600
Query: 551 RIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNL 610
++P +TD+ P L KL + N+G+KL+VLN+LKKM+N+ LEL +C+LERIPH+IFSL+NL
Sbjct: 601 KVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNL 660
Query: 611 HELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIEN 670
ELDL+ NN++T+EEIISFQHL+ L+CLKLWHN I IP I + NLE L +N +E+
Sbjct: 661 QELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLES 720
Query: 671 LPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCL 730
LP+ +F KL LD+SYN+++ IP EI L NLQ+ +T N +++LP LF+C KL+ L
Sbjct: 721 LPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTL 780
Query: 731 LLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTLPL 790
LG+N + +L VG+LS LT LEL GN L+ LP +L C+ LK++ L+VE++L +TLPL
Sbjct: 781 NLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPL 840
Query: 791 PVTERL 796
V E L
Sbjct: 841 EVKEAL 846
>gi|40217803 leucine rich repeat containing 8 family, member E [Homo
sapiens]
Length = 796
Score = 738 bits (1906), Expect = 0.0
Identities = 375/806 (46%), Positives = 530/806 (65%), Gaps = 21/806 (2%)
Query: 1 MITLTELKCLADAQSSYHILKPWWDVFWYYITLIMLLVAVLAGALQLTQSRVLCCLPCKV 60
MI + E K + Q ++ +LKPWWDV Y+T+ ML++ V LQ+TQ +++C LP
Sbjct: 1 MIPVAEFKQFTEQQPAFKVLKPWWDVLAEYLTVAMLMIGVFGCTLQVTQDKIIC-LPNHE 59
Query: 61 EFDNHCAVPWDILKASMNTSSNPGTPLPLPLRI---------QNDLHRQQYSYIDAVCYE 111
+N P L P +P +I +N+L QQYS+I+ +CYE
Sbjct: 60 LQENLSEAPCQQL-----------LPRGIPEQIGALQEVKGLKNNLDLQQYSFINQLCYE 108
Query: 112 KQLHWFAKFFPYLVLLHTLIFAACSNFWLHYPSTSSRLEHFVAILHKCFDSPWTTRALSE 171
LHW+AK+FPYLV++HTLIF C++FW +P TSS++EHF++IL KCFDSPWTTRALSE
Sbjct: 109 TALHWYAKYFPYLVVIHTLIFMVCTSFWFKFPGTSSKIEHFISILGKCFDSPWTTRALSE 168
Query: 172 TVAEQSVRPLKLSKSKILLSSSGCSADIDSGKQSLPYPQPGLESAGIESPTSSVLDKKEG 231
E P ++ + + + +G+ E E P ++LDKKEG
Sbjct: 169 VSGENQKGPAATERAAATIVAMAGTGPGKAGEGEKEKVLAEPEKVVTEPPVVTLLDKKEG 228
Query: 232 EQAKAIFEKVKRFRMHVEQKDIIYRVYLKQIIVKVILFVLIITYVPYFLTHITLEIDCSV 291
EQAKA+FEKVK+FRMHVE+ DI+Y +Y++Q ++KV F+ I+ Y ++ I+ + C V
Sbjct: 229 EQAKALFEKVKKFRMHVEEGDILYTMYIRQTVLKVCKFLAILVYNLVYVEKISFLVACRV 288
Query: 292 DVQAFTGYKRYQCVYSLAEIFKVLASFYVILVILYGLTSSYSLWWMLRSSLKQYSFEALR 351
+ TGY + C ++ A +F LA Y+ V +YGLT Y+L+W+ LK+YSF ++R
Sbjct: 289 ETSEVTGYASFCCNHTKAHLFSKLAFCYISFVCIYGLTCIYTLYWLFHRPLKEYSFRSVR 348
Query: 352 EKSNYSDIPDVKNDFAFILHLADQYDPLYSKRFSIFLSEVSENKLKQINLNNEWTVEKLK 411
E++ DIPDVKNDFAF+LHL DQYD LYSKRF++FLSEVSE++LKQ+NLN+EWT EKL+
Sbjct: 349 EETGMGDIPDVKNDFAFMLHLIDQYDSLYSKRFAVFLSEVSESRLKQLNLNHEWTPEKLR 408
Query: 412 SKLVKNAQDKIELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVY 471
KL +NA ++EL L ML GLPD VFEL+E+E L LE I ++ P +SQLV+L+EL +
Sbjct: 409 QKLQRNAAGRLELALCMLPGLPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLL 468
Query: 472 HSSLVVDHPALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQL 531
HS + FL ++LK++R+K E+ ++P WVF L+ L+EL+L G E L
Sbjct: 469 HSPARLPFSLQVFLRDHLKVMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATL 528
Query: 532 EGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLE 591
E ++LK L+ L L+S+ ++P VTD+ LQ+LSL N+G++LV LN+LKK+ L+ LE
Sbjct: 529 ESLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELE 588
Query: 592 LISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQ 651
L++C LERIPH++FSL L ELDL++N+L+++EEI+SFQH + L L+LWHN IAY+P
Sbjct: 589 LVACGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEH 648
Query: 652 IGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTN 711
+ L +LEQL L +N +E LP QL LC+ L LD+S+N L +P E+ L NLQ+ A++
Sbjct: 649 VRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSY 708
Query: 712 NNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQ 771
N +E LP+ LF C+KL+ LLLG N L LSPHVG L L+ LEL GN LE LP EL C
Sbjct: 709 NALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCG 768
Query: 772 SLKRNCLIVEENLLNTLPLPVTERLQ 797
LK+ L+VE+ L LP V ++++
Sbjct: 769 GLKKAGLLVEDTLYQGLPAEVRDKME 794
>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
Length = 1302
Score = 123 bits (308), Expect = 8e-28
Identities = 103/355 (29%), Positives = 170/355 (47%), Gaps = 11/355 (3%)
Query: 420 DKIELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDH 479
+++ L + LP +F + LSL LP++++ L+NL+EL V + + +
Sbjct: 49 EELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNG-IQEF 107
Query: 480 PALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKN 539
P + L I+ + K+P L NL +LYL+ L E L F L
Sbjct: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFL-EFLPA----NFGRLTK 162
Query: 540 LRTLYLKSSLSRIPQVVTDLLPSLQKLSL-DNEGSKLVVLNNLKKMVNLKSLELISCDLE 598
L+ L L+ + ++ + L L++L L NE +++ + L+++ LK + + L
Sbjct: 163 LQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEV--LEQLSGLKEFWMDANRLT 220
Query: 599 RIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNL 658
IP I SL L LD+ +NN++ VEE IS +NL L L N++ +P IG+L N+
Sbjct: 221 FIPGFIGSLKQLTYLDVSKNNIEMVEEGIST--CENLQDLLLSSNSLQQLPETIGSLKNI 278
Query: 659 EQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLP 718
L +D N + LP + + LD S+N + +P I L+NL+ FA +N ++ LP
Sbjct: 279 TTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLP 338
Query: 719 DGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSL 773
+ K + L L N L L +G++ L + L N L+ LP Q L
Sbjct: 339 PEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQL 393
Score = 108 bits (271), Expect = 2e-23
Identities = 86/279 (30%), Positives = 131/279 (46%), Gaps = 53/279 (18%)
Query: 544 YLKSSLSRIPQVVTDLLPSLQKLSLD-NEGSKLVVLNNLKKMVNLKSLELISC---DLER 599
Y SL ++P+ + +L++L LD N+ +L K++ N +SL +S DL
Sbjct: 29 YSHCSLEQVPKEIFTFEKTLEELYLDANQIEELP-----KQLFNCQSLHKLSLPDNDLTT 83
Query: 600 IPHSIFSLNNLHELDLRENNLKTVEEIIS---------------------FQHLQNLSCL 638
+P SI +L NL ELD+ +N ++ E I F L NL+ L
Sbjct: 84 LPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQL 143
Query: 639 KLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEI 698
L + ++PA G L+ L+ L L N ++ LP + T+L LDL N T +PE +
Sbjct: 144 YLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVL 203
Query: 699 QYLSNLQ-----------------------YFAVTNNNIEMLPDGLFQCKKLQCLLLGKN 735
+ LS L+ Y V+ NNIEM+ +G+ C+ LQ LLL N
Sbjct: 204 EQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSN 263
Query: 736 SLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLK 774
SL L +G L N+T L++ N L LP + G S++
Sbjct: 264 SLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVE 302
Score = 107 bits (266), Expect = 6e-23
Identities = 95/340 (27%), Positives = 157/340 (46%), Gaps = 31/340 (9%)
Query: 472 HSSLVVDHPALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSG---CVLPEQLST 528
H SL + E+ L+ L L ++ ++P+ +F+ ++L +L L LP ++
Sbjct: 31 HCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIAN 90
Query: 529 M--------QLEGFQD----LKNLRTLYLKSS----LSRIPQVVTDLLPSLQKLSLDNEG 572
+ G Q+ +KN + L + + +S++P + LL +L +L L N+
Sbjct: 91 LINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLL-NLTQLYL-NDA 148
Query: 573 SKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHL 632
+ N ++ L+ LEL L+ +P ++ L L LDL N V E++ + L
Sbjct: 149 FLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVL--EQL 206
Query: 633 QNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLT 692
L + N + +IP IG+L L L + NNIE + + C L L LS N L
Sbjct: 207 SGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQ 266
Query: 693 FIPEEIQYLSNLQYFAVTNNNIEMLPD---GLFQCKKLQCLLLGKNSLMNLSPHVGELSN 749
+PE I L N+ + N + LPD GL ++L C N + L +G+L+N
Sbjct: 267 QLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSF---NEVEALPSSIGQLTN 323
Query: 750 LTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTLP 789
L NYL+ LPPE+ +++ L + N L TLP
Sbjct: 324 LRTFAADHNYLQQLPPEIGSWKNI--TVLFLHSNKLETLP 361
Score = 99.8 bits (247), Expect = 9e-21
Identities = 86/346 (24%), Positives = 158/346 (45%), Gaps = 13/346 (3%)
Query: 433 PDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKIL 492
P+N+ + ++ + P KLP SQL+NL +L + + + + PA L+IL
Sbjct: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYL-NDAFLEFLPANFGRLTKLQIL 166
Query: 493 RLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSS-LSR 551
L+ ++ +P+ + L L+ L L E ++ L L+ ++ ++ L+
Sbjct: 167 ELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLE-----QLSGLKEFWMDANRLTF 221
Query: 552 IPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLH 611
IP + L L L + ++V + NL+ L L S L+++P +I SL N+
Sbjct: 222 IPGFIGSL-KQLTYLDVSKNNIEMVE-EGISTCENLQDLLLSSNSLQQLPETIGSLKNIT 279
Query: 612 ELDLRENNLKTVEEIIS-FQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIEN 670
L + EN L + + I ++ L C N + +P+ IG L+NL + DHN ++
Sbjct: 280 TLKIDENQLMYLPDSIGGLISVEELDCS---FNEVEALPSSIGQLTNLRTFAADHNYLQQ 336
Query: 671 LPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCL 730
LP ++ + L L N L +PEE+ + L+ +++N ++ LP + ++L +
Sbjct: 337 LPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAM 396
Query: 731 LLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRN 776
L N L P E + T ++ NY+ P E + N
Sbjct: 397 WLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPRTEDVMFISDN 442
Score = 70.1 bits (170), Expect = 8e-12
Identities = 55/167 (32%), Positives = 72/167 (43%), Gaps = 24/167 (14%)
Query: 633 QNLSCLKLWHNNIAYIPAQIGALSN-LEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHL 691
+ ++ L H ++ +P +I LE+L LD N IE LP QLF C LH L L N L
Sbjct: 22 ETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDL 81
Query: 692 TFIPEEIQYLSNLQYFAVTNNNIE-----------------------MLPDGLFQCKKLQ 728
T +P I L NL+ V+ N I+ LPDG Q L
Sbjct: 82 TTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLT 141
Query: 729 CLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKR 775
L L L L + G L+ L LEL N L+ LP + L+R
Sbjct: 142 QLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLER 188
>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
Length = 1371
Score = 123 bits (308), Expect = 8e-28
Identities = 103/355 (29%), Positives = 170/355 (47%), Gaps = 11/355 (3%)
Query: 420 DKIELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDH 479
+++ L + LP +F + LSL LP++++ L+NL+EL V + + +
Sbjct: 49 EELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNG-IQEF 107
Query: 480 PALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKN 539
P + L I+ + K+P L NL +LYL+ L E L F L
Sbjct: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFL-EFLPA----NFGRLTK 162
Query: 540 LRTLYLKSSLSRIPQVVTDLLPSLQKLSL-DNEGSKLVVLNNLKKMVNLKSLELISCDLE 598
L+ L L+ + ++ + L L++L L NE +++ + L+++ LK + + L
Sbjct: 163 LQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEV--LEQLSGLKEFWMDANRLT 220
Query: 599 RIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNL 658
IP I SL L LD+ +NN++ VEE IS +NL L L N++ +P IG+L N+
Sbjct: 221 FIPGFIGSLKQLTYLDVSKNNIEMVEEGIST--CENLQDLLLSSNSLQQLPETIGSLKNI 278
Query: 659 EQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLP 718
L +D N + LP + + LD S+N + +P I L+NL+ FA +N ++ LP
Sbjct: 279 TTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLP 338
Query: 719 DGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSL 773
+ K + L L N L L +G++ L + L N L+ LP Q L
Sbjct: 339 PEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQL 393
Score = 108 bits (271), Expect = 2e-23
Identities = 86/279 (30%), Positives = 131/279 (46%), Gaps = 53/279 (18%)
Query: 544 YLKSSLSRIPQVVTDLLPSLQKLSLD-NEGSKLVVLNNLKKMVNLKSLELISC---DLER 599
Y SL ++P+ + +L++L LD N+ +L K++ N +SL +S DL
Sbjct: 29 YSHCSLEQVPKEIFTFEKTLEELYLDANQIEELP-----KQLFNCQSLHKLSLPDNDLTT 83
Query: 600 IPHSIFSLNNLHELDLRENNLKTVEEIIS---------------------FQHLQNLSCL 638
+P SI +L NL ELD+ +N ++ E I F L NL+ L
Sbjct: 84 LPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQL 143
Query: 639 KLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEI 698
L + ++PA G L+ L+ L L N ++ LP + T+L LDL N T +PE +
Sbjct: 144 YLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVL 203
Query: 699 QYLSNLQ-----------------------YFAVTNNNIEMLPDGLFQCKKLQCLLLGKN 735
+ LS L+ Y V+ NNIEM+ +G+ C+ LQ LLL N
Sbjct: 204 EQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSN 263
Query: 736 SLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLK 774
SL L +G L N+T L++ N L LP + G S++
Sbjct: 264 SLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVE 302
Score = 107 bits (266), Expect = 6e-23
Identities = 95/340 (27%), Positives = 157/340 (46%), Gaps = 31/340 (9%)
Query: 472 HSSLVVDHPALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSG---CVLPEQLST 528
H SL + E+ L+ L L ++ ++P+ +F+ ++L +L L LP ++
Sbjct: 31 HCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIAN 90
Query: 529 M--------QLEGFQD----LKNLRTLYLKSS----LSRIPQVVTDLLPSLQKLSLDNEG 572
+ G Q+ +KN + L + + +S++P + LL +L +L L N+
Sbjct: 91 LINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLL-NLTQLYL-NDA 148
Query: 573 SKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHL 632
+ N ++ L+ LEL L+ +P ++ L L LDL N V E++ + L
Sbjct: 149 FLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVL--EQL 206
Query: 633 QNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLT 692
L + N + +IP IG+L L L + NNIE + + C L L LS N L
Sbjct: 207 SGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQ 266
Query: 693 FIPEEIQYLSNLQYFAVTNNNIEMLPD---GLFQCKKLQCLLLGKNSLMNLSPHVGELSN 749
+PE I L N+ + N + LPD GL ++L C N + L +G+L+N
Sbjct: 267 QLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSF---NEVEALPSSIGQLTN 323
Query: 750 LTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTLP 789
L NYL+ LPPE+ +++ L + N L TLP
Sbjct: 324 LRTFAADHNYLQQLPPEIGSWKNI--TVLFLHSNKLETLP 361
Score = 99.8 bits (247), Expect = 9e-21
Identities = 86/346 (24%), Positives = 158/346 (45%), Gaps = 13/346 (3%)
Query: 433 PDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKIL 492
P+N+ + ++ + P KLP SQL+NL +L + + + + PA L+IL
Sbjct: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYL-NDAFLEFLPANFGRLTKLQIL 166
Query: 493 RLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSS-LSR 551
L+ ++ +P+ + L L+ L L E ++ L L+ ++ ++ L+
Sbjct: 167 ELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLE-----QLSGLKEFWMDANRLTF 221
Query: 552 IPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLH 611
IP + L L L + ++V + NL+ L L S L+++P +I SL N+
Sbjct: 222 IPGFIGSL-KQLTYLDVSKNNIEMVE-EGISTCENLQDLLLSSNSLQQLPETIGSLKNIT 279
Query: 612 ELDLRENNLKTVEEIIS-FQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIEN 670
L + EN L + + I ++ L C N + +P+ IG L+NL + DHN ++
Sbjct: 280 TLKIDENQLMYLPDSIGGLISVEELDCS---FNEVEALPSSIGQLTNLRTFAADHNYLQQ 336
Query: 671 LPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCL 730
LP ++ + L L N L +PEE+ + L+ +++N ++ LP + ++L +
Sbjct: 337 LPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAM 396
Query: 731 LLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRN 776
L N L P E + T ++ NY+ P E + N
Sbjct: 397 WLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPRTEDVMFISDN 442
Score = 70.1 bits (170), Expect = 8e-12
Identities = 55/167 (32%), Positives = 72/167 (43%), Gaps = 24/167 (14%)
Query: 633 QNLSCLKLWHNNIAYIPAQIGALSN-LEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHL 691
+ ++ L H ++ +P +I LE+L LD N IE LP QLF C LH L L N L
Sbjct: 22 ETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDL 81
Query: 692 TFIPEEIQYLSNLQYFAVTNNNIE-----------------------MLPDGLFQCKKLQ 728
T +P I L NL+ V+ N I+ LPDG Q L
Sbjct: 82 TTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLT 141
Query: 729 CLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKR 775
L L L L + G L+ L LEL N L+ LP + L+R
Sbjct: 142 QLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLER 188
>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
Length = 524
Score = 123 bits (308), Expect = 8e-28
Identities = 103/323 (31%), Positives = 156/323 (48%), Gaps = 20/323 (6%)
Query: 472 HSSLVVDHPALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVL----PEQLS 527
H SLV + +L+ L L ++ ++P F L L++L LS + PE +
Sbjct: 21 HCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIAN 80
Query: 528 TMQLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVL-NNLKKMVN 586
MQL + L S + IP++ + D G+ L L + ++ N
Sbjct: 81 FMQL-----------VELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQN 129
Query: 587 LKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIA 646
L L + L+ +P +I +L NL L+LREN L + + S L+ L L L +N I
Sbjct: 130 LTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPD--SLTQLRRLEELDLGNNEIY 187
Query: 647 YIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQY 706
+P IGAL +L+ L LD N + LP ++ L LD+S N L +PEEI L++L
Sbjct: 188 NLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTD 247
Query: 707 FAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPE 766
++ N +E +PDG+ + KKL L + +N L L VGE +LT L L N L TLP
Sbjct: 248 LVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKS 307
Query: 767 LEGCQSLKRNCLIVEENLLNTLP 789
+ + L L + N L +LP
Sbjct: 308 IGKLKKLSN--LNADRNKLVSLP 328
Score = 119 bits (298), Expect = 1e-26
Identities = 111/375 (29%), Positives = 165/375 (44%), Gaps = 57/375 (15%)
Query: 420 DKIELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDH 479
+++ L L LP+ F+L ++ L L +LP ++ + L EL V +
Sbjct: 39 EELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRN------ 92
Query: 480 PALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKN 539
E+ +IP + K L+ SG L T E F +L+N
Sbjct: 93 ------------------EIPEIPESISFCKALQVADFSGNPL-----TRLPESFPELQN 129
Query: 540 LRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLER 599
L L V D+ SLQ L N+ + NL SLEL L
Sbjct: 130 LTCL-----------SVNDI--SLQSLP-----------ENIGNLYNLASLELRENLLTY 165
Query: 600 IPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLE 659
+P S+ L L ELDL N + + E S L +L L L N ++ +P +IG L NL
Sbjct: 166 LPDSLTQLRRLEELDLGNNEIYNLPE--SIGALLHLKDLWLDGNQLSELPQEIGNLKNLL 223
Query: 660 QLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPD 719
L + N +E LP ++ T L L +S N L IP+ I L L V N + LP+
Sbjct: 224 CLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPE 283
Query: 720 GLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLI 779
+ +C+ L L+L +N L+ L +G+L L++L N L +LP E+ GC SL C
Sbjct: 284 AVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFC-- 341
Query: 780 VEENLLNTLPLPVTE 794
V +N L +P V++
Sbjct: 342 VRDNRLTRIPAEVSQ 356
Score = 108 bits (270), Expect = 2e-23
Identities = 101/364 (27%), Positives = 178/364 (48%), Gaps = 14/364 (3%)
Query: 432 LPDNVFELTE-MEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLK 490
+P+ ++ +E L L+ +LP QLV L++L + + + P +A + ++
Sbjct: 27 VPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVE 86
Query: 491 ILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKS-SL 549
L + E+ +IP + K L+ SG L T E F +L+NL L + SL
Sbjct: 87 -LDVSRNEIPEIPESISFCKALQVADFSGNPL-----TRLPESFPELQNLTCLSVNDISL 140
Query: 550 SRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNN 609
+P+ + +L +L L L E + ++L ++ L+ L+L + ++ +P SI +L +
Sbjct: 141 QSLPENIGNLY-NLASLEL-RENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLH 198
Query: 610 LHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIE 669
L +L L N L + + I +L+NL CL + N + +P +I L++L L + N +E
Sbjct: 199 LKDLWLDGNQLSELPQEIG--NLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLE 256
Query: 670 NLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQC 729
+P + KL L + N LT +PE + +L +T N + LP + + KKL
Sbjct: 257 TIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSN 316
Query: 730 LLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTLP 789
L +N L++L +G +LT + N L +P E+ Q+ + + L V N L LP
Sbjct: 317 LNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVS--QATELHVLDVAGNRLLHLP 374
Query: 790 LPVT 793
L +T
Sbjct: 375 LSLT 378
Score = 89.0 bits (219), Expect = 2e-17
Identities = 100/359 (27%), Positives = 150/359 (41%), Gaps = 36/359 (10%)
Query: 429 LNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEEN 488
L LP++ EL + LS+ I LP + L NL L + + L +L L
Sbjct: 117 LTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRR- 175
Query: 489 LKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSS 548
L+ L L E+ +P + L +LK+L+L G QLS + E +LKNL L + +
Sbjct: 176 LEELDLGNNEIYNLPESIGALLHLKDLWLDG----NQLSELPQE-IGNLKNLLCLDVSEN 230
Query: 549 -LSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSL 607
L R+P+ ++ L + LV+ NL LE IP I L
Sbjct: 231 RLERLPEEISGLTSL----------TDLVISQNL---------------LETIPDGIGKL 265
Query: 608 NNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNN 667
L L + +N L + E + ++L+ L L N + +P IG L L L+ D N
Sbjct: 266 KKLSILKVDQNRLTQLPEAVG--ECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNK 323
Query: 668 IENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKL 727
+ +LP ++ C L + N LT IP E+ + L V N + LP L KL
Sbjct: 324 LVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSL-TALKL 382
Query: 728 QCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLN 786
+ L L N L + T +++ L P CQ C + ENL+N
Sbjct: 383 KALWLSDNQSQPLLTFQTDTDYTTGEKILTCVLLPQLPSEPTCQENLPRCGAL-ENLVN 440
Score = 67.0 bits (162), Expect = 7e-11
Identities = 79/340 (23%), Positives = 144/340 (42%), Gaps = 64/340 (18%)
Query: 422 IELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPA 481
+EL +L LPD++ +L +E L L LP ++ L++LK+L
Sbjct: 156 LELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDL------------- 202
Query: 482 LAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLR 541
+L+ N ++ ++P+ + +LKNL L +S
Sbjct: 203 --WLDGN---------QLSELPQEIGNLKNLLCLDVS----------------------- 228
Query: 542 TLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIP 601
++ L R+P+ ++ L SL L + ++ + + + K+ L L++ L ++P
Sbjct: 229 ----ENRLERLPEEISG-LTSLTDLVI-SQNLLETIPDGIGKLKKLSILKVDQNRLTQLP 282
Query: 602 HSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQL 661
++ +L EL L EN L T+ + S L+ LS L N + +P +IG +L
Sbjct: 283 EAVGECESLTELVLTENQLLTLPK--SIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVF 340
Query: 662 SLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEML---- 717
+ N + +P ++ T+LH LD++ N L +P + L + N + +L
Sbjct: 341 CVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSLTALKLKALWLSDNQSQPLLTFQT 400
Query: 718 -PDGLFQCKKLQCLLL----GKNSLMNLSPHVGELSNLTH 752
D K L C+LL + + P G L NL +
Sbjct: 401 DTDYTTGEKILTCVLLPQLPSEPTCQENLPRCGALENLVN 440
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 119 bits (298), Expect = 1e-26
Identities = 106/346 (30%), Positives = 165/346 (47%), Gaps = 43/346 (12%)
Query: 472 HSSLVVDHPALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVL----PEQLS 527
H SL + +L+ L L ++ ++P+ F L NL++L LS + PE +
Sbjct: 21 HCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVAN 80
Query: 528 TMQLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVL-NNLKKMVN 586
MQL + L S + IP++ + D G+ L L + ++ +
Sbjct: 81 FMQL-----------VELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRS 129
Query: 587 LKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIA 646
L L L L+ +P + +L NL L+LREN LK++ +SF L L L L N++
Sbjct: 130 LAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSF--LVKLEQLDLGGNDLE 187
Query: 647 YIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQY 706
+P +GAL NL +L LD N + LP +L +L LD+S N L +P E+ L L
Sbjct: 188 VLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTD 247
Query: 707 FAVTNNNIEMLPDGLFQ-----------------------CKKLQCLLLGKNSLMNLSPH 743
++ N + LPDG+ Q C+ L L+L +N LM L
Sbjct: 248 LLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRS 307
Query: 744 VGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTLP 789
+G+L+ LT+L + N+LE LPPE+ GC +L + L + +N L LP
Sbjct: 308 LGKLTKLTNLNVDRNHLEALPPEIGGCVAL--SVLSLRDNRLAVLP 351
Score = 105 bits (262), Expect = 2e-22
Identities = 107/367 (29%), Positives = 174/367 (47%), Gaps = 14/367 (3%)
Query: 429 LNGLPDNVFELTE-MEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEE 487
L +P+ ++ + +E L L+ +LP +L+NL++L + + + P +A +
Sbjct: 24 LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ 83
Query: 488 NLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKS 547
++ L + ++ +IP + K L+ SG LS + +GF L++L L L
Sbjct: 84 LVE-LDVSRNDIPEIPESIKFCKALEIADFSG----NPLSRLP-DGFTQLRSLAHLALND 137
Query: 548 -SLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFS 606
SL +P V +L +L L L K + + L +V L+ L+L DLE +P ++ +
Sbjct: 138 VSLQALPGDVGNLA-NLVTLELRENLLKSLPAS-LSFLVKLEQLDLGGNDLEVLPDTLGA 195
Query: 607 LNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHN 666
L NL EL L N L + + +L+ L CL + N + +PA++G L L L L N
Sbjct: 196 LPNLRELWLDRNQLSALPPELG--NLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQN 253
Query: 667 NIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKK 726
+ LP + +L L + N L + E I NL +T N + LP L + K
Sbjct: 254 LLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTK 313
Query: 727 LQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLN 786
L L + +N L L P +G L+ L L N L LPPEL + + + L V N L
Sbjct: 314 LTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPEL--AHTTELHVLDVAGNRLQ 371
Query: 787 TLPLPVT 793
+LP +T
Sbjct: 372 SLPFALT 378
Score = 78.6 bits (192), Expect = 2e-14
Identities = 91/323 (28%), Positives = 142/323 (43%), Gaps = 26/323 (8%)
Query: 429 LNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEEN 488
L+ LPD +L + L+L + LP V L NL L + + L +L+FL +
Sbjct: 117 LSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVK- 175
Query: 489 LKILRLKFTEMGKIPRWVFHLKNLKELYLSG---CVLPEQLSTMQLEGFQDLKNLRTLYL 545
L+ L L ++ +P + L NL+EL+L LP +L ++ D+ R L
Sbjct: 176 LEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEEL 235
Query: 546 KSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLER---IPH 602
+ L + ++TDLL S L +G + LK L ++ D R +
Sbjct: 236 PAELGGLV-LLTDLLLSQNLLRRLPDG-----------IGQLKQLSILKVDQNRLCEVTE 283
Query: 603 SIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLS 662
+I NL EL L EN L + S L L+ L + N++ +P +IG L LS
Sbjct: 284 AIGDCENLSELILTENLLMALPR--SLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLS 341
Query: 663 LDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEML----- 717
L N + LP +L T+LH LD++ N L +P + +L+ + N ML
Sbjct: 342 LRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHLNLKALWLAENQAQPMLRFQTE 401
Query: 718 PDGLFQCKKLQCLLLGKNSLMNL 740
D K L C LL + ++L
Sbjct: 402 DDARTGEKVLTCYLLPQQPPLSL 424
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 119 bits (298), Expect = 1e-26
Identities = 106/346 (30%), Positives = 165/346 (47%), Gaps = 43/346 (12%)
Query: 472 HSSLVVDHPALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVL----PEQLS 527
H SL + +L+ L L ++ ++P+ F L NL++L LS + PE +
Sbjct: 21 HCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVAN 80
Query: 528 TMQLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVL-NNLKKMVN 586
MQL + L S + IP++ + D G+ L L + ++ +
Sbjct: 81 FMQL-----------VELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRS 129
Query: 587 LKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIA 646
L L L L+ +P + +L NL L+LREN LK++ +SF L L L L N++
Sbjct: 130 LAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSF--LVKLEQLDLGGNDLE 187
Query: 647 YIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQY 706
+P +GAL NL +L LD N + LP +L +L LD+S N L +P E+ L L
Sbjct: 188 VLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTD 247
Query: 707 FAVTNNNIEMLPDGLFQ-----------------------CKKLQCLLLGKNSLMNLSPH 743
++ N + LPDG+ Q C+ L L+L +N LM L
Sbjct: 248 LLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRS 307
Query: 744 VGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTLP 789
+G+L+ LT+L + N+LE LPPE+ GC +L + L + +N L LP
Sbjct: 308 LGKLTKLTNLNVDRNHLEALPPEIGGCVAL--SVLSLRDNRLAVLP 351
Score = 105 bits (262), Expect = 2e-22
Identities = 107/367 (29%), Positives = 174/367 (47%), Gaps = 14/367 (3%)
Query: 429 LNGLPDNVFELTE-MEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEE 487
L +P+ ++ + +E L L+ +LP +L+NL++L + + + P +A +
Sbjct: 24 LQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ 83
Query: 488 NLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKS 547
++ L + ++ +IP + K L+ SG LS + +GF L++L L L
Sbjct: 84 LVE-LDVSRNDIPEIPESIKFCKALEIADFSG----NPLSRLP-DGFTQLRSLAHLALND 137
Query: 548 -SLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFS 606
SL +P V +L +L L L K + + L +V L+ L+L DLE +P ++ +
Sbjct: 138 VSLQALPGDVGNLA-NLVTLELRENLLKSLPAS-LSFLVKLEQLDLGGNDLEVLPDTLGA 195
Query: 607 LNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHN 666
L NL EL L N L + + +L+ L CL + N + +PA++G L L L L N
Sbjct: 196 LPNLRELWLDRNQLSALPPELG--NLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQN 253
Query: 667 NIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKK 726
+ LP + +L L + N L + E I NL +T N + LP L + K
Sbjct: 254 LLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTK 313
Query: 727 LQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLN 786
L L + +N L L P +G L+ L L N L LPPEL + + + L V N L
Sbjct: 314 LTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPEL--AHTTELHVLDVAGNRLQ 371
Query: 787 TLPLPVT 793
+LP +T
Sbjct: 372 SLPFALT 378
Score = 78.6 bits (192), Expect = 2e-14
Identities = 91/323 (28%), Positives = 142/323 (43%), Gaps = 26/323 (8%)
Query: 429 LNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEEN 488
L+ LPD +L + L+L + LP V L NL L + + L +L+FL +
Sbjct: 117 LSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVK- 175
Query: 489 LKILRLKFTEMGKIPRWVFHLKNLKELYLSG---CVLPEQLSTMQLEGFQDLKNLRTLYL 545
L+ L L ++ +P + L NL+EL+L LP +L ++ D+ R L
Sbjct: 176 LEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEEL 235
Query: 546 KSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLER---IPH 602
+ L + ++TDLL S L +G + LK L ++ D R +
Sbjct: 236 PAELGGLV-LLTDLLLSQNLLRRLPDG-----------IGQLKQLSILKVDQNRLCEVTE 283
Query: 603 SIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLS 662
+I NL EL L EN L + S L L+ L + N++ +P +IG L LS
Sbjct: 284 AIGDCENLSELILTENLLMALPR--SLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLS 341
Query: 663 LDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEML----- 717
L N + LP +L T+LH LD++ N L +P + +L+ + N ML
Sbjct: 342 LRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHLNLKALWLAENQAQPMLRFQTE 401
Query: 718 PDGLFQCKKLQCLLLGKNSLMNL 740
D K L C LL + ++L
Sbjct: 402 DDARTGEKVLTCYLLPQQPPLSL 424
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 115 bits (289), Expect = 1e-25
Identities = 122/437 (27%), Positives = 212/437 (48%), Gaps = 61/437 (13%)
Query: 402 NNEWTVEKLKSKLVKNAQDKIELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQ 461
+N +++L +N+ +++L ++ LP ++ ELT++ L L LP+ V
Sbjct: 86 SNAEVIKELNKCREENSM-RLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGC 144
Query: 462 LVNLKELRVYHSSLVVDHPALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCV 521
LVNL L + +SL +L L++ L++L L+ ++ +IP V+ L +L LYL
Sbjct: 145 LVNLMTLALSENSLTSLPDSLDNLKK-LRMLDLRHNKLREIPSVVYRLDSLTTLYLRF-- 201
Query: 522 LPEQLSTMQLEGFQDLKNLRTLYL----KSSLSRIPQVVTDL---------------LPS 562
+++T++ +D+KNL L + ++ + ++P + +L LP
Sbjct: 202 --NRITTVE----KDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPK 255
Query: 563 -----LQKLSLDNEGSKLVVL-NNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLR 616
Q +LD + ++L+ L + + + +L L L L IP S+ + L EL+L
Sbjct: 256 EIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLE 315
Query: 617 ENNLKTVEE--IISFQHLQNL----SCLKLW-----------------HNNIAYIPAQIG 653
NN+ T+ E + S L +L +C +L+ HN I IP I
Sbjct: 316 NNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIF 375
Query: 654 ALSN-LEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNN 712
+ + L +L++ N + +LPL T + L+L+ N LT IPE++ L +L+ ++NN
Sbjct: 376 SRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNN 435
Query: 713 NIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQS 772
++ LP GL +KL+ L L +N L +L + L +L L L N L TLP + +
Sbjct: 436 LLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTN 495
Query: 773 LKRNCLIVEENLLNTLP 789
L L + ENLL LP
Sbjct: 496 LTH--LGLGENLLTHLP 510
Score = 112 bits (281), Expect = 1e-24
Identities = 104/361 (28%), Positives = 171/361 (47%), Gaps = 19/361 (5%)
Query: 435 NVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDH-PALAFLEENLKILR 493
++ L+++ +LS+ +LP+ + +L NL L V H+ L +H P + L
Sbjct: 210 DIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQL--EHLPKEIGNCTQITNLD 267
Query: 494 LKFTEMGKIPRWVFHLKNLKEL---YLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSLS 550
L+ E+ +P + +L +L L Y +P L+ +L+N +++S
Sbjct: 268 LQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLEN-------NNIS 320
Query: 551 RIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNN- 609
+P+ + L L L+L +L + + + SL + + +IP IFS
Sbjct: 321 TLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKV 380
Query: 610 LHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIE 669
L +L++++N L ++ + F ++ L L N + IP + L +LE L L +N ++
Sbjct: 381 LSKLNMKDNQLTSLP--LDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLK 438
Query: 670 NLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQC 729
LP L KL LDL N L +P EI YL +LQ +TNN + LP G+ L
Sbjct: 439 KLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTH 498
Query: 730 LLLGKNSLMNLSPHVGELSNLTHLELIGN-YLETLPPELEGCQSLKRNCLIVEENLLNTL 788
L LG+N L +L +G L NL L L N L +LP EL C L + + +E L+ L
Sbjct: 499 LGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALCSKL--SIMSIENCPLSHL 556
Query: 789 P 789
P
Sbjct: 557 P 557
Score = 90.5 bits (223), Expect = 6e-18
Identities = 87/284 (30%), Positives = 147/284 (51%), Gaps = 17/284 (5%)
Query: 421 KIELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLP-SAVSQLVNLKELRVYHSSLVVDH 479
++ L L+ +P ++ + + +E L+LE LP S +S LV L L + + +
Sbjct: 288 RLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYP 347
Query: 480 PALAFLEENLKILRLKFTEMGKIPRWVF-HLKNLKELYLSGCVLPEQLSTMQLEGFQDLK 538
+ L ++ + KIP +F K L +L + QL+++ L+ F
Sbjct: 348 VGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKD----NQLTSLPLD-FGTWT 402
Query: 539 NLRTLYLKSS-LSRIPQVVTDLLPSLQKLSLDNEGSKLVV--LNNLKKMVNLKSLELISC 595
++ L L ++ L++IP+ V+ L+ SL+ L L N K + L NL+K L+ L+L
Sbjct: 403 SMVELNLATNQLTKIPEDVSGLV-SLEVLILSNNLLKKLPHGLGNLRK---LRELDLEEN 458
Query: 596 DLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGAL 655
LE +P+ I L +L +L L N L T+ I HL NL+ L L N + ++P +IG L
Sbjct: 459 KLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIG--HLTNLTHLGLGENLLTHLPEEIGTL 516
Query: 656 SNLEQLSLDHN-NIENLPLQLFLCTKLHYLDLSYNHLTFIPEEI 698
NLE+L L+ N N+ +LP +L LC+KL + + L+ +P +I
Sbjct: 517 ENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLPPQI 560
Score = 88.2 bits (217), Expect = 3e-17
Identities = 71/261 (27%), Positives = 117/261 (44%), Gaps = 5/261 (1%)
Query: 530 QLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKS 589
+L ++ ++R K S+ +P + +L + N+ L + +VNL +
Sbjct: 93 ELNKCREENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPA--EVGCLVNLMT 150
Query: 590 LELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIP 649
L L L +P S+ +L L LDLR N L+ + ++ L +L+ L L N I +
Sbjct: 151 LALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVV--YRLDSLTTLYLRFNRITTVE 208
Query: 650 AQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAV 709
I LS L LS+ N I+ LP ++ L LD+++N L +P+EI + + +
Sbjct: 209 KDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDL 268
Query: 710 TNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEG 769
+N + LPD + L L L N L + + + S L L L N + TLP L
Sbjct: 269 QHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLS 328
Query: 770 CQSLKRNCLIVEENLLNTLPL 790
+K N L + N P+
Sbjct: 329 -SLVKLNSLTLARNCFQLYPV 348
>gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
Length = 860
Score = 115 bits (287), Expect = 2e-25
Identities = 113/396 (28%), Positives = 191/396 (48%), Gaps = 40/396 (10%)
Query: 429 LNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEEN 488
L+ LP + L + +L++ +P +SQL N+++L ++++ + + P+ N
Sbjct: 200 LSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQL-FFYNNYIENFPSDLECLGN 258
Query: 489 LKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSS 548
L+IL L ++ IP + LK L+ L L QL+T + L L +L L +
Sbjct: 259 LEILSLGKNKLRHIPDTLPSLKTLRVLNLEY----NQLTTFP-KALCFLPKLISLDLTGN 313
Query: 549 L-SRIPQVVTDLLPSLQKLSLDNEGSKLVVLN-NLKKMVNLKSLELISCDLERIPHSIFS 606
L S +P+ + +L +L+ L +D+ +KL L + +++ +K L+L LE I H I +
Sbjct: 314 LISSLPKEIREL-KNLETLLMDH--NKLTFLAVEIFQLLKIKELQLADNKLEVISHKIEN 370
Query: 607 LNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHN 666
L L L +N LK + E IS + L CL L N + +P I L+NL +L ++ N
Sbjct: 371 FRELRILILDKNLLKNIPEKISCCAM--LECLSLSDNKLTELPKYIHKLNNLRKLHVNRN 428
Query: 667 N-----------------------IENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSN 703
N I ++P+++ C K+ ++LSYN + + P + L +
Sbjct: 429 NMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDS 488
Query: 704 LQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETL 763
L Y +V N I +P + K+L L L +N L+ S H L NL +L+L N ++ +
Sbjct: 489 LYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKI 548
Query: 764 PPELEGCQSLKRNCLIVEENLLNTLP--LPVTERLQ 797
P + SL + LI+ N T P L E LQ
Sbjct: 549 PASISNMISL--HVLILCCNKFETFPRELCTLENLQ 582
Score = 97.8 bits (242), Expect = 3e-20
Identities = 67/216 (31%), Positives = 111/216 (51%), Gaps = 8/216 (3%)
Query: 584 MVNLKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHN 643
++ L+ L L L +P I L+NL L++ N++ + + IS L N+ L ++N
Sbjct: 187 LLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEIS--QLGNIRQLFFYNN 244
Query: 644 NIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSN 703
I P+ + L NLE LSL N + ++P L L L+L YN LT P+ + +L
Sbjct: 245 YIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPK 304
Query: 704 LQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETL 763
L +T N I LP + + K L+ LL+ N L L+ + +L + L+L N LE +
Sbjct: 305 LISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVI 364
Query: 764 PPELEGCQSLKRNCLIVEENLLNTLPLPVTERLQTC 799
++E + L+ LI+++NLL +P E++ C
Sbjct: 365 SHKIENFRELR--ILILDKNLLKNIP----EKISCC 394
Score = 96.3 bits (238), Expect = 1e-19
Identities = 81/298 (27%), Positives = 134/298 (44%), Gaps = 32/298 (10%)
Query: 492 LRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSLSR 551
+ L+ + + P+ + +K +K LYL Q+ T Q DL L L
Sbjct: 146 VNLEAKGLQEFPKDILKIKYVKYLYLD----KNQIKTFQGADSGDLLGLEIL-------- 193
Query: 552 IPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLH 611
SLQ+ L + S++ +L+NL+ L + + IP I L N+
Sbjct: 194 ----------SLQENGLSSLPSEIQLLHNLR------ILNVSHNHISHIPKEISQLGNIR 237
Query: 612 ELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENL 671
+L N ++ + L NL L L N + +IP + +L L L+L++N +
Sbjct: 238 QLFFYNNYIENFPS--DLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTF 295
Query: 672 PLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLL 731
P L KL LDL+ N ++ +P+EI+ L NL+ + +N + L +FQ K++ L
Sbjct: 296 PKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQ 355
Query: 732 LGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTLP 789
L N L +S + L L L N L+ +P ++ C L+ CL + +N L LP
Sbjct: 356 LADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLE--CLSLSDNKLTELP 411
Score = 84.7 bits (208), Expect = 3e-16
Identities = 103/376 (27%), Positives = 165/376 (43%), Gaps = 43/376 (11%)
Query: 428 MLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSL-VVDHPALAFLE 486
+++ LP + EL +E L ++ L + QL+ +KEL++ + L V+ H F E
Sbjct: 314 LISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRE 373
Query: 487 ENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYL- 545
L+IL L + IP + L+ L LS L E + L NLR L++
Sbjct: 374 --LRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIH-----KLNNLRKLHVN 426
Query: 546 KSSLSRIPQVVTDLLPSLQKL-SLDNEGSKL----VVLNNLKKMVNLK------------ 588
++++ +I TD + L + SL+ G+ + + + N +K++ ++
Sbjct: 427 RNNMVKI----TDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLG 482
Query: 589 -----SLELISCD---LERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKL 640
SL +S + + IP I L L+L EN L E F L NL L L
Sbjct: 483 LCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSE--HFCSLINLKYLDL 540
Query: 641 WHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQY 700
N I IPA I + +L L L N E P +L L LDLS N L I +I
Sbjct: 541 GKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICN 600
Query: 701 LSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLT---HLELIG 757
L +Q ++N P L Q + L+ L + + L+ GELSN+T L++
Sbjct: 601 LKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISN 660
Query: 758 NYLETLPPELEGCQSL 773
N + +P + ++L
Sbjct: 661 NAIREIPRNIGELRNL 676
Score = 79.7 bits (195), Expect = 1e-14
Identities = 56/153 (36%), Positives = 78/153 (50%), Gaps = 4/153 (2%)
Query: 650 AQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAV 709
A G L LE LSL N + +LP ++ L L L++S+NH++ IP+EI L N++
Sbjct: 182 ADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFF 241
Query: 710 TNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEG 769
NN IE P L L+ L LGKN L ++ + L L L L N L T P L
Sbjct: 242 YNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKAL-- 299
Query: 770 CQSLKRNCLIVEENLLNTLPLPVTE--RLQTCL 800
C K L + NL+++LP + E L+T L
Sbjct: 300 CFLPKLISLDLTGNLISSLPKEIRELKNLETLL 332
Score = 79.0 bits (193), Expect = 2e-14
Identities = 97/431 (22%), Positives = 188/431 (43%), Gaps = 41/431 (9%)
Query: 390 EVSENKLKQINLN----NEWTVEKLKSKLVKNAQDKIELHLFM---------LNGLPDNV 436
++++NKL+ I+ E + L L+KN +KI + L LP +
Sbjct: 355 QLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYI 414
Query: 437 FELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKILRLKF 496
+L + L + VK+ +S L N+ L + +++ D P + + + L +
Sbjct: 415 HKLNNLRKLHVNRNNMVKITDCISHLNNICSLE-FSGNIITDVPIEIKNCQKIIKIELSY 473
Query: 497 TEMGKIPRWVFHLKNLKELYLSGCVLPE---------QLSTMQL---------EGFQDLK 538
++ P + L +L L ++G + E QL ++L E F L
Sbjct: 474 NKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLI 533
Query: 539 NLRTLYL-KSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDL 597
NL+ L L K+ + +IP +++++ SL L L + L + NL+ L+L L
Sbjct: 534 NLKYLDLGKNQIKKIPASISNMI-SLHVLILCCNKFETFP-RELCTLENLQVLDLSENQL 591
Query: 598 ERIPHSIFSLNNLHELDLRENN-LKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALS 656
++I I +L + +L+ N + E+ Q L+ L+ ++ + +P ++ ++
Sbjct: 592 QKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMT 651
Query: 657 NLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEM 716
L++L + +N I +P + L L N ++++P + L++LQ ++ NN+
Sbjct: 652 QLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTA 711
Query: 717 LPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRN 776
LP ++ L+ + N L L P V E+ L I YL+ E + L++
Sbjct: 712 LPSAIYNIFSLKEINFDDNPL--LRPPV-EICKGKQLYTIARYLQRADERDE--KILEKI 766
Query: 777 CLIVEENLLNT 787
IV N+ T
Sbjct: 767 FKIVANNITET 777
>gi|4503743 flightless I homolog [Homo sapiens]
Length = 1269
Score = 112 bits (281), Expect = 1e-24
Identities = 105/364 (28%), Positives = 171/364 (46%), Gaps = 38/364 (10%)
Query: 433 PDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLE------ 486
P+NV +T + L L LP ++ L L+ L V H++L H L+ L
Sbjct: 26 PENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIV 85
Query: 487 ------------------ENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLST 528
++L +L L ++ + PR + + KN+ L LS + T
Sbjct: 86 ARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSH----NSIDT 141
Query: 529 MQLEGFQDLKNLRTLYLKSSLSRIPQVVTDL--LPSLQKLSLDNEGSKLVVLNNLKKMVN 586
+ + F +L +L LYL S +R+ + + L LQ L L+ L L M
Sbjct: 142 IPNQLFINLTDL--LYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTA 199
Query: 587 LKSLELISCDLER--IPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNN 644
L++L L S + +P S+ L+NL ++DL N+L V E + L +L L L N
Sbjct: 200 LQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECL--YTLPSLRRLNLSSNQ 257
Query: 645 IAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTF--IPEEIQYLS 702
I + I ++E L+L N + +LP + +KL L L+ N L F +P I L+
Sbjct: 258 ITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLT 317
Query: 703 NLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLET 762
NL+ F NNN+E++P+ L +C KL+ L+L KN L+ L + L+ + L++ N
Sbjct: 318 NLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLV 377
Query: 763 LPPE 766
+PP+
Sbjct: 378 MPPK 381
Score = 90.5 bits (223), Expect = 6e-18
Identities = 83/313 (26%), Positives = 142/313 (45%), Gaps = 50/313 (15%)
Query: 430 NGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENL 489
+G+PD++F+L ++ VL L + P + N+ L + H+S+ L +L
Sbjct: 94 SGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDL 153
Query: 490 KILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSL 549
L L + +P + L +L+ L L+G L QL + L+TL+L+S+
Sbjct: 154 LYLDLSENRLESLPPQMRRLVHLQTLVLNG----NPLLHAQLRQLPAMTALQTLHLRST- 208
Query: 550 SRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNN 609
+ ++L SL+ LS NL ++L DL R+P +++L +
Sbjct: 209 ---QRTQSNLPTSLEGLS------------------NLADVDLSCNDLTRVPECLYTLPS 247
Query: 610 LHELDLRENNLKTVEEIIS-FQHLQNLSC--------------------LKLWHNNIAY- 647
L L+L N + + I + H++ L+ L L N + +
Sbjct: 248 LRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFD 307
Query: 648 -IPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQY 706
+P+ IG L+NLE+ +NN+E +P L C KL L L+ NHL +PE I +L+ ++
Sbjct: 308 GLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEV 367
Query: 707 FAVTNN-NIEMLP 718
V N N+ M P
Sbjct: 368 LDVRENPNLVMPP 380
>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
Length = 1537
Score = 107 bits (267), Expect = 4e-23
Identities = 109/378 (28%), Positives = 168/378 (44%), Gaps = 40/378 (10%)
Query: 420 DKIELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDH 479
+++ L + LP +F + LS+ LP+ ++ LVNLKEL + + V +
Sbjct: 49 EELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNG-VQEF 107
Query: 480 PALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKN 539
P + L I+ + K+P L NL +LYL+ L E L F L
Sbjct: 108 PENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFL-EFLPA----NFGRLVK 162
Query: 540 LRTLYLKSS-LSRIPQVVTDLLPSLQKLSLDNE--GSKLVVLNNLKKMVNLKSLELISCD 596
LR L L+ + L +P+ + L L++L L N G VL+ ++ NL+ L + +
Sbjct: 163 LRILELRENHLKTLPKSMHKLA-QLERLDLGNNEFGELPEVLDQIQ---NLRELWMDNNA 218
Query: 597 LERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALS 656
L+ +P SI L L LD+ +N ++TV+ IS
Sbjct: 219 LQVLPGSIGKLKMLVYLDMSKNRIETVDMDIS-------------------------GCE 253
Query: 657 NLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEM 716
LE L L N ++ LP + L KL L + N LT +P I LS L+ F + N +E
Sbjct: 254 ALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELES 313
Query: 717 LPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRN 776
LP + L+ L + +N L L +G N+T + L N LE LP E+ Q L+
Sbjct: 314 LPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLR-- 371
Query: 777 CLIVEENLLNTLPLPVTE 794
L + +N L LP T+
Sbjct: 372 VLNLSDNRLKNLPFSFTK 389
Score = 105 bits (261), Expect = 2e-22
Identities = 78/250 (31%), Positives = 133/250 (53%), Gaps = 13/250 (5%)
Query: 544 YLKSSLSRIPQVVTDLLPSLQKLSLD-NEGSKLVVLNNLKKMVNLKSLELISC---DLER 599
Y SL ++P+ V + +L++L LD N+ +L K++ N ++L +S DL
Sbjct: 29 YSHCSLQQVPKEVFNFERTLEELYLDANQIEELP-----KQLFNCQALRKLSIPDNDLSN 83
Query: 600 IPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLE 659
+P +I SL NL ELD+ +N ++ E I + L+ ++ N I+ +P L NL
Sbjct: 84 LPTTIASLVNLKELDISKNGVQEFPENIKC--CKCLTIIEASVNPISKLPDGFTQLLNLT 141
Query: 660 QLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPD 719
QL L+ +E LP KL L+L NHL +P+ + L+ L+ + NN LP+
Sbjct: 142 QLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPE 201
Query: 720 GLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLI 779
L Q + L+ L + N+L L +G+L L +L++ N +ET+ ++ GC++L+ L+
Sbjct: 202 VLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALED--LL 259
Query: 780 VEENLLNTLP 789
+ N+L LP
Sbjct: 260 LSSNMLQQLP 269
>gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo
sapiens]
Length = 560
Score = 102 bits (253), Expect = 2e-21
Identities = 96/313 (30%), Positives = 143/313 (45%), Gaps = 35/313 (11%)
Query: 502 IPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLP 561
IP +F L+E++L Q+ + E Q LKN+R LYL + R LL
Sbjct: 40 IPLEIFTFTELEEVHLEN----NQIEEIPQE-IQRLKNIRVLYLDKNNLRSLCPALGLLS 94
Query: 562 SLQKLSLDNE---GSKLVVLNNLKKMVNLKSLELISCDLERIPHSIF-SLNNLHELDLRE 617
SL+ L L S LVV++ L L+ L L DL+ IP IF +L++L L L
Sbjct: 95 SLESLDLSYNPIFSSSLVVVSFLHA---LRELRLYQTDLKEIPVVIFKNLHHLELLGLTG 151
Query: 618 NNLKTV-EEIISFQHLQN--------------------LSCLKLWHNNIAYIPAQIGALS 656
N+LK + +EI++ L+ L + L N I IP +IG L+
Sbjct: 152 NHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLT 211
Query: 657 NLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEM 716
L++ + NN+ LP L C++L LDLS+N L IP+ L + ++ N +E
Sbjct: 212 GLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEK 271
Query: 717 LPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRN 776
+P + + L L LG L L L NL L+L N+L P L+ C
Sbjct: 272 VPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCP--LQICALKNLE 329
Query: 777 CLIVEENLLNTLP 789
L +++N + LP
Sbjct: 330 VLGLDDNKIGQLP 342
Score = 100 bits (248), Expect = 7e-21
Identities = 121/438 (27%), Positives = 178/438 (40%), Gaps = 96/438 (21%)
Query: 429 LNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEE- 487
L +P +F TE+E + LE ++P + +L N++ L + ++L PAL L
Sbjct: 37 LTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPALGLLSSL 96
Query: 488 ----------------------NLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCV---- 521
L+ LRL T++ +IP +F KNL L L G
Sbjct: 97 ESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIF--KNLHHLELLGLTGNHL 154
Query: 522 --LPEQ-----------LSTMQLEGF-QDLKNLRTLYL----KSSLSRIPQVVTDLLPSL 563
LP++ L Q E F Q+L L TL + ++ + IP+ + L L
Sbjct: 155 KCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLT-GL 213
Query: 564 QKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTV 623
QK + + V+ +L + L L+L L IP S L + E+ L N L+ V
Sbjct: 214 QKFYMASNNLP-VLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKV 272
Query: 624 EEII---------------------SFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLS 662
+I SF+ L NL L L N++ + P QI AL NLE L
Sbjct: 273 PRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLG 332
Query: 663 LDHNNIENLPLQLFLCTKLHYLDLSYNH--------------------------LTFIPE 696
LD N I LP +L +KL L L+ N LT++PE
Sbjct: 333 LDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPE 392
Query: 697 EIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELI 756
I+ L +L+ + NN++E LP L L+ L N L L + + L L L
Sbjct: 393 HIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLE 452
Query: 757 GNYLETLPPELEGCQSLK 774
N L LP L+ +LK
Sbjct: 453 DNLLTHLPENLDSLVNLK 470
Score = 96.3 bits (238), Expect = 1e-19
Identities = 97/370 (26%), Positives = 169/370 (45%), Gaps = 30/370 (8%)
Query: 423 ELHLFM--LNGLPDNVFE-LTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDH 479
EL L+ L +P +F+ L +E+L L LP + L+E+ + + V
Sbjct: 122 ELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFP 181
Query: 480 PALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLP---------EQLSTMQ 530
L L L+I+ L ++G IP + HL L++ Y++ LP QLS +
Sbjct: 182 QELCVLY-TLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLD 240
Query: 531 L---------EGFQDLKNLRTLYLKSS-LSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNN 580
L + F +L+ + + L + L ++P+++ SL L L N G + +
Sbjct: 241 LSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWT-SLHLLYLGNTGLHRL-RGS 298
Query: 581 LKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKL 640
+ +VNL+ L+L L P I +L NL L L +N + + + L L L L
Sbjct: 299 FRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELG--SLSKLKILGL 356
Query: 641 WHNNIAYIPAQIGALSNLEQLSLDHNN---IENLPLQLFLCTKLHYLDLSYNHLTFIPEE 697
N P ++ +L++LE+L + + + +P + L L + NHL ++P
Sbjct: 357 TGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVS 416
Query: 698 IQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIG 757
+ + NL+ +N ++ LPD + Q + L+ L L N L +L ++ L NL L L+
Sbjct: 417 LGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKVLTLMD 476
Query: 758 NYLETLPPEL 767
N +E P E+
Sbjct: 477 NPMEEPPKEV 486
Score = 82.8 bits (203), Expect = 1e-15
Identities = 90/333 (27%), Positives = 153/333 (45%), Gaps = 16/333 (4%)
Query: 391 VSENKLKQINLNNEWTVEKLKSKLVKNAQDKIELHLFMLNGLPDNVFELTEMEVLSLELI 450
V++ KL++I L + V + I+L + +P+ + LT ++ +
Sbjct: 162 VNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASN 221
Query: 451 PEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKILRLKFTEMGKIPRWVFHLK 510
LP+++ Q L L + H+ L + A L + +I L + K+PR +
Sbjct: 222 NLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEI-GLSGNRLEKVPRLICRWT 280
Query: 511 NLKELYLSGCVLPEQLSTMQLEG-FQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLD 569
+L LYL L +L G F+ L NLR L L + + L +L+ L LD
Sbjct: 281 SLHLLYLGNTGLH------RLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLD 334
Query: 570 NEGSKLVVL-NNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLRENN---LKTVEE 625
+ +K+ L + L + LK L L + P + SL +L +L + ++ L V E
Sbjct: 335 D--NKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPE 392
Query: 626 IISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLD 685
I + LQ+L L + +N++ Y+P +G++ NLE L HN ++ LP + L L
Sbjct: 393 HI--RKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELR 450
Query: 686 LSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLP 718
L N LT +PE + L NL+ + +N +E P
Sbjct: 451 LEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPP 483
Score = 50.8 bits (120), Expect = 5e-06
Identities = 29/76 (38%), Positives = 44/76 (57%)
Query: 683 YLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSP 742
++D S LT IP EI + L+ + NN IE +P + + K ++ L L KN+L +L P
Sbjct: 29 FIDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCP 88
Query: 743 HVGELSNLTHLELIGN 758
+G LS+L L+L N
Sbjct: 89 ALGLLSSLESLDLSYN 104
Score = 48.5 bits (114), Expect = 2e-05
Identities = 39/154 (25%), Positives = 65/154 (42%), Gaps = 27/154 (17%)
Query: 661 LSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDG 720
+ + ++ +PL++F T+L + L N + IP+EIQ L N++ + NN+ L
Sbjct: 30 IDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPA 89
Query: 721 LFQCKKLQCLLLGKNSLMNLSPHVGE----------------------LSNLTHLELI-- 756
L L+ L L N + + S V NL HLEL+
Sbjct: 90 LGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGL 149
Query: 757 -GNYLETLPPELEGCQSLKRNCLIVEENLLNTLP 789
GN+L+ LP E+ L+ + ++ N P
Sbjct: 150 TGNHLKCLPKEIVNQTKLRE--IYLKRNQFEVFP 181
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 100 bits (250), Expect = 4e-21
Identities = 75/241 (31%), Positives = 136/241 (56%), Gaps = 12/241 (4%)
Query: 554 QVVTD---LLPSLQKLSL-DNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNN 609
Q +TD LLP+L L + DN+ + L + ++++ NL+ L + L+ +P I +L N
Sbjct: 95 QSLTDDLRLLPALTVLDIHDNQLTSLP--SAIRELENLQKLNVSHNKLKILPEEITNLRN 152
Query: 610 LHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIE 669
L L L+ N L + E F+ L NL L L +N++ +PA +LS+L +L+L N ++
Sbjct: 153 LKCLYLQHNELTCISE--GFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELK 210
Query: 670 NLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQC 729
+LP ++ +L +LD + N L IP E+ + +L+ + N + LP+ C L+
Sbjct: 211 SLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPE-FPSCSLLKE 269
Query: 730 LLLGKNSLMNL-SPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTL 788
L +G+N + L + H+ L+++ L+L N L+++P E+ +SL+R L + N +++L
Sbjct: 270 LHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLER--LDLSNNDISSL 327
Query: 789 P 789
P
Sbjct: 328 P 328
Score = 93.6 bits (231), Expect = 7e-19
Identities = 58/181 (32%), Positives = 95/181 (52%), Gaps = 4/181 (2%)
Query: 609 NLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNI 668
+L +L + N L+++ + + L L+ L + N + +P+ I L NL++L++ HN +
Sbjct: 83 DLTKLIISNNKLQSLTDDLRL--LPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKL 140
Query: 669 ENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQ 728
+ LP ++ L L L +N LT I E + LSNL+ ++NN++ +P L
Sbjct: 141 KILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLV 200
Query: 729 CLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTL 788
L L N L +L + + L HL+ N LET+PPEL G +SL+ L + N L L
Sbjct: 201 RLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLE--LLYLRRNKLRFL 258
Query: 789 P 789
P
Sbjct: 259 P 259
Score = 87.8 bits (216), Expect = 4e-17
Identities = 111/446 (24%), Positives = 192/446 (43%), Gaps = 74/446 (16%)
Query: 391 VSENKLKQI--------NL------NNEWTVEKLKSKLVKNAQDKIELHLFMLNGLPDNV 436
VS NKLK + NL +NE T + + N +D ++L L +P +
Sbjct: 135 VSHNKLKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLED-LDLSNNHLTTVPASF 193
Query: 437 FELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKILRLKF 496
L+ + L+L LP+ ++++ LK L + L P LA +E +L++L L+
Sbjct: 194 SSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGME-SLELLYLRR 252
Query: 497 TEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSS-LSRIPQV 555
++ +P + LKEL++ Q+ ++ E + L ++ L L+ + L +P
Sbjct: 253 NKLRFLPEFP-SCSLLKELHVG----ENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDE 307
Query: 556 VTDLLPSLQKLSLDNE--GSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLHEL 613
+ LL SL++L L N S L NL +LK L L L I I S L
Sbjct: 308 II-LLRSLERLDLSNNDISSLPYSLGNL----HLKFLALEGNPLRTIRREIISKGTQEVL 362
Query: 614 DLRENNLK-----------------------TVEEIISFQHLQN---------------- 634
+ +K + II+ + L
Sbjct: 363 KYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAV 422
Query: 635 ----LSCLKLWHNNIAYIPAQIGALSNL-EQLSLDHNNIENLPLQLFLCTKLHYLDLSYN 689
++ + N + IP ++ L + + L N + + L+L + KL +LDL N
Sbjct: 423 KSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNN 482
Query: 690 HLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPH-VGELS 748
L +PEE++ L LQ ++ N +MLP+ L++ L+ +L+ N + ++ P + +
Sbjct: 483 FLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMME 542
Query: 749 NLTHLELIGNYLETLPPELEGCQSLK 774
NLT L+L N L +PPEL C +L+
Sbjct: 543 NLTTLDLQNNDLLQIPPELGNCVNLR 568
Score = 83.6 bits (205), Expect = 7e-16
Identities = 114/440 (25%), Positives = 178/440 (40%), Gaps = 104/440 (23%)
Query: 429 LNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEEN 488
L L D++ L + VL + LPSA+ +L NL++L V H+ L +
Sbjct: 94 LQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKI----------- 142
Query: 489 LKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSS 548
+P + +L+NLK LYL L T EGF+ L NL L L ++
Sbjct: 143 -------------LPEEITNLRNLKCLYLQHNEL-----TCISEGFEQLSNLEDLDLSNN 184
Query: 549 -LSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSL 607
L+ +P + L SL +L+L + K + + +M LK L+ S LE IP + +
Sbjct: 185 HLTTVPASFSS-LSSLVRLNLSSNELKSLPA-EINRMKRLKHLDCNSNLLETIPPELAGM 242
Query: 608 NNLHELDLRENNLKTVEEIIS---------------------FQHLQNLSCLKLWHNNIA 646
+L L LR N L+ + E S +HL ++ L L N +
Sbjct: 243 ESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLK 302
Query: 647 YIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEI-------- 698
+P +I L +LE+L L +N+I +LP L L +L L N L I EI
Sbjct: 303 SVPDEIILLRSLERLDLSNNDISSLPYSLG-NLHLKFLALEGNPLRTIRREIISKGTQEV 361
Query: 699 -QYLSN---------------------------------LQYFAVTNNNIEMLPDGLFQC 724
+YL + L+ ++ ++PD +F
Sbjct: 362 LKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDA 421
Query: 725 KK---LQCLLLGKNSLMNLSPHVGELSNL-THLELIGNYLETLPPELEGCQSLKRNCLIV 780
K + + KN L + + EL + + ++L N L + LE C K L +
Sbjct: 422 VKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFI--SLELCVLQKLTFLDL 479
Query: 781 EENLLNTLP--LPVTERLQT 798
N LN+LP + RLQT
Sbjct: 480 RNNFLNSLPEEMESLVRLQT 499
Score = 78.2 bits (191), Expect = 3e-14
Identities = 47/137 (34%), Positives = 75/137 (54%), Gaps = 2/137 (1%)
Query: 656 SNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIE 715
++L +L + +N +++L L L L LD+ N LT +P I+ L NLQ V++N ++
Sbjct: 82 TDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLK 141
Query: 716 MLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKR 775
+LP+ + + L+CL L N L +S +LSNL L+L N+L T+P SL R
Sbjct: 142 ILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVR 201
Query: 776 NCLIVEENLLNTLPLPV 792
L + N L +LP +
Sbjct: 202 --LNLSSNELKSLPAEI 216
Score = 58.5 bits (140), Expect = 2e-08
Identities = 91/364 (25%), Positives = 161/364 (44%), Gaps = 43/364 (11%)
Query: 379 LYSKRFSI-FLSEV-SENKLKQINLNNEWTVEKLKSKLVKNAQDKIELHLF--MLNGLPD 434
LY +R + FL E S + LK++++ E +E L+++ +K+ + L L L +PD
Sbjct: 248 LYLRRNKLRFLPEFPSCSLLKELHVG-ENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPD 306
Query: 435 NVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAF--LEENLKIL 492
+ L +E L L LP ++ L +LK L + + L + +E LK L
Sbjct: 307 EIILLRSLERLDLSNNDISSLPYSLGNL-HLKFLALEGNPLRTIRREIISKGTQEVLKYL 365
Query: 493 RLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSLSRI 552
R K + G + + LP + S + + LK L Y + I
Sbjct: 366 RSKIKDDGP--------SQSESATETAMTLPSE-SRVNIHAIITLKILD--YSDKQATLI 414
Query: 553 PQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLHE 612
P V D + S S++ ++L + K+MV LK E++S +
Sbjct: 415 PDEVFDAVKSNIVTSINFSKNQLCEIP--KRMVELK--EMVS-----------------D 453
Query: 613 LDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLP 672
+DL N L + + LQ L+ L L +N + +P ++ +L L+ ++L N + LP
Sbjct: 454 VDLSFNKLSFIS--LELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLP 511
Query: 673 LQLFLCTKLHYLDLSYNHLTFI-PEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLL 731
L+ L + +S N + + P++++ + NL + NN++ +P L C L+ LL
Sbjct: 512 EVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLL 571
Query: 732 LGKN 735
L N
Sbjct: 572 LDGN 575
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 97.4 bits (241), Expect = 5e-20
Identities = 76/240 (31%), Positives = 122/240 (50%), Gaps = 7/240 (2%)
Query: 553 PQVVTDL-LPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSL-NNL 610
PQ+V L ++ L+L N G + V + +L+ L L R+P ++ L ++L
Sbjct: 54 PQLVLPANLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHL 113
Query: 611 HELDLRENNLKTV-EEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIE 669
ELD+ N L + E++S L+ L L L HN + +PAQ+GAL++LE+L + N +
Sbjct: 114 TELDVSHNRLTALGAEVVSA--LRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLA 171
Query: 670 NLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQC 729
+LP L ++L LD+ +N LT P ++ L L+ V++N + LP+ + + L+
Sbjct: 172 HLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKI 231
Query: 730 LLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTLP 789
L L L L EL++L L L N L+ LP + Q LK L + NL P
Sbjct: 232 LWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLK--MLNLSSNLFEEFP 289
Score = 90.1 bits (222), Expect = 7e-18
Identities = 95/334 (28%), Positives = 143/334 (42%), Gaps = 36/334 (10%)
Query: 439 LTEMEVLSLELIPEVKLPSAVSQLVN-LKELRVYHSSLVVDHPALAFLEENLKILRLKFT 497
L + VL L +LP AV++L + L EL V H+ L + L+ L L
Sbjct: 86 LGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTALGAEVVSALRELRKLNLSHN 145
Query: 498 EMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSLSRIPQVVT 557
++ +P + L +L+EL D+ R +L SLS + ++ T
Sbjct: 146 QLPALPAQLGALAHLEEL--------------------DVSFNRLAHLPDSLSCLSRLRT 185
Query: 558 DLLPSLQKLSLDNEGSKLVVL-NNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLR 616
LD + ++L L ++V L+ L++ S L +P I +L L L L
Sbjct: 186 ----------LDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLS 235
Query: 617 ENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLF 676
L T+ F L +L L L +N + +PAQ L L+ L+L N E P L
Sbjct: 236 GAELGTLPA--GFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALL 293
Query: 677 LCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNS 736
L L LS N LT +P I L L + NN I LPD + + L+ L+L N
Sbjct: 294 PLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQ 353
Query: 737 LMNLSPHVGELSNLTHLELIGNYLETLPPELEGC 770
+ L H G+LS + ++ N L + P E C
Sbjct: 354 IAVLPDHFGQLSRVGLWKIKDNPL--IQPPYEVC 385
Score = 44.3 bits (103), Expect = 5e-04
Identities = 55/235 (23%), Positives = 112/235 (47%), Gaps = 15/235 (6%)
Query: 349 ALRE----KSNYSDIPDVKNDFAFILHLADQYDPLYSKRFSIFLSEVSENKLKQINLNNE 404
ALRE +++ +P + + HL ++ D +++ + S ++L+ +++++
Sbjct: 133 ALRELRKLNLSHNQLPALPAQLGALAHL-EELDVSFNRLAHLPDSLSCLSRLRTLDVDHN 191
Query: 405 WTVEKLKSKLVKNAQDKIELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVN 464
+ L A +++++ L GLP+++ L +++L L LP+ +L +
Sbjct: 192 QLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELAS 251
Query: 465 LKELRVYHSSLVVDHPALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPE 524
L+ L + ++ L PA + LK+L L + P + L L+ELYLS L
Sbjct: 252 LESLMLDNNGLQA-LPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTS 310
Query: 525 QLSTMQLEGFQDLKNLRTLYLKSSLSR-IPQVVTDLLPSLQKLSLDNEGSKLVVL 578
S + L L TL+L ++ R +P + + L L++L L +G+++ VL
Sbjct: 311 VPSLI-----SGLGRLLTLWLDNNRIRYLPDSIVE-LTGLEELVL--QGNQIAVL 357
>gi|61742786 leucine rich repeat and death domain containing protein
isoform 3 [Homo sapiens]
Length = 893
Score = 95.5 bits (236), Expect = 2e-19
Identities = 80/255 (31%), Positives = 128/255 (50%), Gaps = 14/255 (5%)
Query: 514 ELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSL-QKLSLDNEG 572
+LY GC +QL + ++ Q L+ L+ +L+ S PQ++ L L Q LS
Sbjct: 41 DLYPGGC---QQLLHLCVQ--QPLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSC---- 91
Query: 573 SKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHL 632
+ +VL ++ L + + L +P + L +L LDL N+L+T+ + +
Sbjct: 92 LRSLVLKGGQRRDTLGAC--LRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVL--QM 147
Query: 633 QNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLT 692
+ L L L HN ++ +P +GAL L L++ HN ++ LP L + L LDLS N L
Sbjct: 148 RGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLD 207
Query: 693 FIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTH 752
+P EI L +L + +N ++ LP L + L+ L+L N L ++ + L LT
Sbjct: 208 TLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTR 267
Query: 753 LELIGNYLETLPPEL 767
L+L N L LPPEL
Sbjct: 268 LDLRDNQLRDLPPEL 282
Score = 85.9 bits (211), Expect = 1e-16
Identities = 56/154 (36%), Positives = 83/154 (53%), Gaps = 7/154 (4%)
Query: 648 IPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYF 707
+PA + L++L L L N++E LP + L L LS+N L+ +PE + L L +
Sbjct: 117 LPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFL 176
Query: 708 AVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPEL 767
VT+N ++ LP L LQ L L +N L L P +G L +L L L N L++LP L
Sbjct: 177 TVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASL 236
Query: 768 EGCQSLKRNCLIVEENLLNTLP-----LPVTERL 796
G +SL+ L++ NLL ++P LP+ RL
Sbjct: 237 AGLRSLR--LLVLHSNLLASVPADLARLPLLTRL 268
Score = 66.2 bits (160), Expect = 1e-10
Identities = 44/122 (36%), Positives = 62/122 (50%), Gaps = 2/122 (1%)
Query: 668 IENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKL 727
+ NLP L L +LDLS+N L +P + + L +++N + LP+ L L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
Query: 728 QCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNT 787
L + N L L P +G LS L L+L N L+TLPPE+ G SL L + N L +
Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLE--LNLASNRLQS 231
Query: 788 LP 789
LP
Sbjct: 232 LP 233
Score = 35.0 bits (79), Expect = 0.28
Identities = 50/153 (32%), Positives = 70/153 (45%), Gaps = 11/153 (7%)
Query: 422 IELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPA 481
++L L LP V ++ + L L +LP A+ L L L V H+ L PA
Sbjct: 130 LDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPA 189
Query: 482 LAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLR 541
L L L+ L L + +P + L +L EL L+ L Q L G L++LR
Sbjct: 190 LGAL-STLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRL--QSLPASLAG---LRSLR 243
Query: 542 TLYLKSSLSRIPQVVTDL--LPSLQKLSL-DNE 571
L L S+L + V DL LP L +L L DN+
Sbjct: 244 LLVLHSNL--LASVPADLARLPLLTRLDLRDNQ 274
>gi|61742784 leucine rich repeat and death domain containing protein
isoform 1 [Homo sapiens]
Length = 910
Score = 95.5 bits (236), Expect = 2e-19
Identities = 80/255 (31%), Positives = 128/255 (50%), Gaps = 14/255 (5%)
Query: 514 ELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSL-QKLSLDNEG 572
+LY GC +QL + ++ Q L+ L+ +L+ S PQ++ L L Q LS
Sbjct: 41 DLYPGGC---QQLLHLCVQ--QPLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSC---- 91
Query: 573 SKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHL 632
+ +VL ++ L + + L +P + L +L LDL N+L+T+ + +
Sbjct: 92 LRSLVLKGGQRRDTLGAC--LRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVL--QM 147
Query: 633 QNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLT 692
+ L L L HN ++ +P +GAL L L++ HN ++ LP L + L LDLS N L
Sbjct: 148 RGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLD 207
Query: 693 FIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTH 752
+P EI L +L + +N ++ LP L + L+ L+L N L ++ + L LT
Sbjct: 208 TLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTR 267
Query: 753 LELIGNYLETLPPEL 767
L+L N L LPPEL
Sbjct: 268 LDLRDNQLRDLPPEL 282
Score = 85.9 bits (211), Expect = 1e-16
Identities = 56/154 (36%), Positives = 83/154 (53%), Gaps = 7/154 (4%)
Query: 648 IPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYF 707
+PA + L++L L L N++E LP + L L LS+N L+ +PE + L L +
Sbjct: 117 LPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFL 176
Query: 708 AVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPEL 767
VT+N ++ LP L LQ L L +N L L P +G L +L L L N L++LP L
Sbjct: 177 TVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASL 236
Query: 768 EGCQSLKRNCLIVEENLLNTLP-----LPVTERL 796
G +SL+ L++ NLL ++P LP+ RL
Sbjct: 237 AGLRSLR--LLVLHSNLLASVPADLARLPLLTRL 268
Score = 66.2 bits (160), Expect = 1e-10
Identities = 44/122 (36%), Positives = 62/122 (50%), Gaps = 2/122 (1%)
Query: 668 IENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKL 727
+ NLP L L +LDLS+N L +P + + L +++N + LP+ L L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
Query: 728 QCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNT 787
L + N L L P +G LS L L+L N L+TLPPE+ G SL L + N L +
Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLE--LNLASNRLQS 231
Query: 788 LP 789
LP
Sbjct: 232 LP 233
Score = 35.0 bits (79), Expect = 0.28
Identities = 50/153 (32%), Positives = 70/153 (45%), Gaps = 11/153 (7%)
Query: 422 IELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPA 481
++L L LP V ++ + L L +LP A+ L L L V H+ L PA
Sbjct: 130 LDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPA 189
Query: 482 LAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLR 541
L L L+ L L + +P + L +L EL L+ L Q L G L++LR
Sbjct: 190 LGAL-STLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRL--QSLPASLAG---LRSLR 243
Query: 542 TLYLKSSLSRIPQVVTDL--LPSLQKLSL-DNE 571
L L S+L + V DL LP L +L L DN+
Sbjct: 244 LLVLHSNL--LASVPADLARLPLLTRLDLRDNQ 274
>gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens]
Length = 277
Score = 92.8 bits (229), Expect = 1e-18
Identities = 63/214 (29%), Positives = 102/214 (47%), Gaps = 27/214 (12%)
Query: 609 NLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNI 668
N E+D+ + + + ++ L +++ L L HN + +P I L NLE L+ +N I
Sbjct: 16 NQPEVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQI 75
Query: 669 ENLPLQLFLCTKLHY-----------------------LDLSYNHLT--FIPEEIQYLSN 703
E LP Q+ KL + LDL+YN+L+ +P YL+
Sbjct: 76 EELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTT 135
Query: 704 LQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETL 763
L+ +++N+ E+LP + + KLQ L L N L++L +GEL+ L L + GN L L
Sbjct: 136 LRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVL 195
Query: 764 PPELEGCQSLKRNCLIVEENLLNTLPLPVTERLQ 797
PPEL + + EN N P+ ++ Q
Sbjct: 196 PPELGNLDLTGQKQVFKAEN--NPWVTPIADQFQ 227
Score = 62.4 bits (150), Expect = 2e-09
Identities = 55/188 (29%), Positives = 87/188 (46%), Gaps = 6/188 (3%)
Query: 529 MQLEGFQDLKNLRTLYLK-SSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNL 587
+ + G L ++ L L + L+ +P + +L +L+ L+ N + + + + L
Sbjct: 31 LDVNGLFTLSHITQLVLSHNKLTMVPPNIAEL-KNLEVLNFFNNQIEELP-TQISSLQKL 88
Query: 588 KSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAY 647
K L L L +P SL L LDL NNL +F +L L L L N+
Sbjct: 89 KHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEI 148
Query: 648 IPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYL---SNL 704
+P IG L+ L+ LSL N++ +LP ++ T+L L + N LT +P E+ L
Sbjct: 149 LPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQK 208
Query: 705 QYFAVTNN 712
Q F NN
Sbjct: 209 QVFKAENN 216
Score = 37.4 bits (85), Expect = 0.056
Identities = 19/55 (34%), Positives = 32/55 (58%)
Query: 432 LPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLE 486
LP ++ +LT++++LSL + LP + +L LKEL + + L V P L L+
Sbjct: 149 LPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLD 203
Score = 37.0 bits (84), Expect = 0.073
Identities = 43/156 (27%), Positives = 72/156 (46%), Gaps = 18/156 (11%)
Query: 429 LNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEEN 488
L +P N+ EL +EVL+ +LP+ +S L LK L + + L L
Sbjct: 52 LTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPA- 110
Query: 489 LKILRLKFTEMGK--IPRWVFHLKNLKELYLSGC---VLPEQLSTMQLEGFQDLKNLRTL 543
L++L L + + + +P F+L L+ LYLS +LP + L L+ L
Sbjct: 111 LEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIG--------KLTKLQIL 162
Query: 544 YLK-SSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVL 578
L+ + L +P+ + +L Q L +G++L VL
Sbjct: 163 SLRDNDLISLPKEIGEL---TQLKELHIQGNRLTVL 195
>gi|34577083 ras suppressor protein 1 isoform 2 [Homo sapiens]
Length = 224
Score = 92.8 bits (229), Expect = 1e-18
Identities = 57/168 (33%), Positives = 88/168 (52%), Gaps = 4/168 (2%)
Query: 632 LQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHL 691
L+NL L ++N I +P QI +L L+ L+L N + LP L LDL+YN+L
Sbjct: 9 LKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNL 68
Query: 692 T--FIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSN 749
+ +P YL+ L+ +++N+ E+LP + + KLQ L L N L++L +GEL+
Sbjct: 69 SENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQ 128
Query: 750 LTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTLPLPVTERLQ 797
L L + GN L LPPEL + + EN N P+ ++ Q
Sbjct: 129 LKELHIQGNRLTVLPPELGNLDLTGQKQVFKAEN--NPWVTPIADQFQ 174
Score = 60.1 bits (144), Expect = 8e-09
Identities = 45/135 (33%), Positives = 63/135 (46%), Gaps = 3/135 (2%)
Query: 581 LKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKL 640
+ + LK L L L +P SL L LDL NNL +F +L L L L
Sbjct: 29 ISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYL 88
Query: 641 WHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQY 700
N+ +P IG L+ L+ LSL N++ +LP ++ T+L L + N LT +P E+
Sbjct: 89 SDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGN 148
Query: 701 L---SNLQYFAVTNN 712
L Q F NN
Sbjct: 149 LDLTGQKQVFKAENN 163
Score = 43.1 bits (100), Expect = 0.001
Identities = 46/155 (29%), Positives = 75/155 (48%), Gaps = 8/155 (5%)
Query: 502 IPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLP 561
+P + LKNL+ L + E+L T Q+ Q LK+L + L+ +P+ L P
Sbjct: 2 VPPNIAELKNLEVLNFFNNQI-EELPT-QISSLQKLKHLNLGM--NRLNTLPRGFGSL-P 56
Query: 562 SLQKLSLD-NEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLRENNL 620
+L+ L L N S+ + N + L++L L D E +P I L L L LR+N+L
Sbjct: 57 ALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDL 116
Query: 621 KTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGAL 655
++ + I L L L + N + +P ++G L
Sbjct: 117 ISLPKEIG--ELTQLKELHIQGNRLTVLPPELGNL 149
Score = 37.4 bits (85), Expect = 0.056
Identities = 19/55 (34%), Positives = 32/55 (58%)
Query: 432 LPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLE 486
LP ++ +LT++++LSL + LP + +L LKEL + + L V P L L+
Sbjct: 96 LPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLD 150
Score = 36.6 bits (83), Expect = 0.095
Identities = 42/153 (27%), Positives = 71/153 (46%), Gaps = 18/153 (11%)
Query: 432 LPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKI 491
+P N+ EL +EVL+ +LP+ +S L LK L + + L L L++
Sbjct: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPA-LEV 60
Query: 492 LRLKFTEMGK--IPRWVFHLKNLKELYLSGC---VLPEQLSTMQLEGFQDLKNLRTLYLK 546
L L + + + +P F+L L+ LYLS +LP + L L+ L L+
Sbjct: 61 LDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIG--------KLTKLQILSLR 112
Query: 547 -SSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVL 578
+ L +P+ + +L Q L +G++L VL
Sbjct: 113 DNDLISLPKEIGEL---TQLKELHIQGNRLTVL 142
Score = 32.7 bits (73), Expect = 1.4
Identities = 22/74 (29%), Positives = 31/74 (41%)
Query: 716 MLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKR 775
M+P + + K L+ L N + L + L L HL L N L TLP +L+
Sbjct: 1 MVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEV 60
Query: 776 NCLIVEENLLNTLP 789
L N+LP
Sbjct: 61 LDLTYNNLSENSLP 74
>gi|193788651 leucine rich repeat containing 69 [Homo sapiens]
Length = 347
Score = 88.2 bits (217), Expect = 3e-17
Identities = 67/225 (29%), Positives = 111/225 (49%), Gaps = 15/225 (6%)
Query: 571 EGSKLVVLNNLK---------KMVNLKSLELISCDLERIPHSIFSLNNLHELDLRENNLK 621
+ +K++ LN K K+ LK+L L + + ++ + +L L L+L N L+
Sbjct: 14 KNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLE 73
Query: 622 TVEEIISFQHLQNLSCLKLWHNNIA-YIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTK 680
V E ++L +L L L N I + P L NL L+L++N++ LP ++
Sbjct: 74 EVPE--EMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKS 131
Query: 681 LHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNL 740
L Y+ ++YN L IP E+ +L NL + N + +P+ + KKLQ LLL +N++ L
Sbjct: 132 LTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIGVL 191
Query: 741 SPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLL 785
+ +L L L++ GN ++ P G Q LK E N L
Sbjct: 192 PEELCDLKKLRILDIAGNIIQIFP---SGFQDLKLREFYCEGNPL 233
Score = 85.1 bits (209), Expect = 2e-16
Identities = 63/201 (31%), Positives = 103/201 (51%), Gaps = 8/201 (3%)
Query: 538 KNLRTLYLKSS-LSRIPQVVTDLLPSLQKLSLDNEGSKLV--VLNNLKKMVNLKSLELIS 594
KN + + L ++++P + L P L+ L L N L+ V L + L +L L +
Sbjct: 14 KNTKIITLNGKKMTKMPSALGKL-PGLKTLVLQNN---LIPKVCPELCNLTQLTTLNLGN 69
Query: 595 CDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGA 654
LE +P + L +L L L N + + LQNL L L +N++ +P ++
Sbjct: 70 NLLEEVPEEMKYLTSLKNLHLSGNRICRFAPG-ACDGLQNLILLNLNNNHLTQLPQEVSR 128
Query: 655 LSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNI 714
L +L +S+++N + ++P +L L L L+YN L IPEEI++L LQ + NNI
Sbjct: 129 LKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNI 188
Query: 715 EMLPDGLFQCKKLQCLLLGKN 735
+LP+ L KKL+ L + N
Sbjct: 189 GVLPEELCDLKKLRILDIAGN 209
Score = 73.6 bits (179), Expect = 7e-13
Identities = 70/259 (27%), Positives = 120/259 (46%), Gaps = 37/259 (14%)
Query: 487 ENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLK 546
+N KI+ L +M K+P + L LK L L ++P+
Sbjct: 14 KNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPK---------------------- 51
Query: 547 SSLSRIPQVVTDLLPSLQKLSLDNEGSKLV--VLNNLKKMVNLKSLELISCDLERI-PHS 603
V L +L +L+ N G+ L+ V +K + +LK+L L + R P +
Sbjct: 52 ---------VCPELCNLTQLTTLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGA 102
Query: 604 IFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSL 663
L NL L+L N+L + + +S L++L+ + + +N +A IP ++ L NL +L L
Sbjct: 103 CDGLQNLILLNLNNNHLTQLPQEVS--RLKSLTYMSINYNQLASIPRELCFLENLVELQL 160
Query: 664 DHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQ 723
++N + +P ++ KL L L+ N++ +PEE+ L L+ + N I++ P G FQ
Sbjct: 161 NYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSG-FQ 219
Query: 724 CKKLQCLLLGKNSLMNLSP 742
KL+ N L P
Sbjct: 220 DLKLREFYCEGNPLFLQQP 238
Score = 42.0 bits (97), Expect = 0.002
Identities = 34/120 (28%), Positives = 59/120 (49%), Gaps = 7/120 (5%)
Query: 429 LNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEEN 488
L LP V L + +S+ +P + L NL EL++ ++ L+ + FL++
Sbjct: 119 LTQLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKL 178
Query: 489 LKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSS 548
K+L L +G +P + LK L+ L ++G ++ + GFQDLK LR Y + +
Sbjct: 179 QKLL-LARNNIGVLPEELCDLKKLRILDIAGNII-----QIFPSGFQDLK-LREFYCEGN 231
Score = 40.4 bits (93), Expect = 0.007
Identities = 37/117 (31%), Positives = 60/117 (51%), Gaps = 12/117 (10%)
Query: 439 LTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKILRLKFTE 498
L + +L+L +LP VS+L +L + + ++ L L FL ENL L+L + +
Sbjct: 106 LQNLILLNLNNNHLTQLPQEVSRLKSLTYMSINYNQLASIPRELCFL-ENLVELQLNYNQ 164
Query: 499 MGKIPRWVFHLKNLKELYLSG---CVLPEQLSTMQLEGFQDLKNLRTLYLKSSLSRI 552
+ IP + LK L++L L+ VLPE+L DLK LR L + ++ +I
Sbjct: 165 LICIPEEIKFLKKLQKLLLARNNIGVLPEELC--------DLKKLRILDIAGNIIQI 213
>gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
Length = 907
Score = 87.4 bits (215), Expect = 5e-17
Identities = 97/334 (29%), Positives = 161/334 (48%), Gaps = 26/334 (7%)
Query: 454 KLPSAVSQLVNLKELRVYHSSLVVDHP--ALAFLEENLKILRLKFTEMGKIPRWVFH-LK 510
+LPS +S + +L + + S ++ +P +L FLEE LRL + IP+ F L
Sbjct: 59 ELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEE----LRLAGNALTYIPKGAFTGLY 114
Query: 511 NLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSS-LSRIPQVVTDLLPSLQKLSLD 569
+LK L L QL + E Q+L++L++L L ++ +S +P L SL+ L LD
Sbjct: 115 SLKVLMLQN----NQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLD 170
Query: 570 NEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIF-SLNNLHELDLRENNLKTVEEIIS 628
+ + + + + L+++ L + IP F +L++L L L N + ++ +
Sbjct: 171 DNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKC- 229
Query: 629 FQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFL----CTKLHYL 684
F L +L L L +NN+ P I LSNL++L NNI ++P + F+ +H+
Sbjct: 230 FDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFY 289
Query: 685 DLSYNHLTFIPEE-IQYLSNLQYFAVTN-NNIEMLPDGLFQCKKLQCLLLGKNSLMNLSP 742
D N + F+ Q+L L+ + + I PD L L+ L L + +L
Sbjct: 290 D---NPIQFVGRSAFQHLPELRTLTLNGASQITEFPD-LTGTANLESLTLTGAQISSLPQ 345
Query: 743 HV-GELSNLTHLELIGNYLETLPPELEGCQSLKR 775
V +L NL L+L N LE L P CQ L++
Sbjct: 346 TVCNQLPNLQVLDLSYNLLEDL-PSFSVCQKLQK 378
Score = 74.3 bits (181), Expect = 4e-13
Identities = 102/405 (25%), Positives = 172/405 (42%), Gaps = 81/405 (20%)
Query: 429 LNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEEN 488
L+ LP N+ T LS+ I ++ LP+ + L L+ELR+ ++L +
Sbjct: 57 LSELPSNLSVFTSYLDLSMNNISQL-LPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYS 115
Query: 489 LKILRLKFTEMGKIPRWVF-HLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLK- 546
LK+L L+ ++ +P +L++L+ L L +S + F L +LR L+L
Sbjct: 116 LKVLMLQNNQLRHVPTEALQNLRSLQSLRLDA----NHISYVPPSCFSGLHSLRHLWLDD 171
Query: 547 SSLSRIPQVVTDLLPSLQKLSLD------------NEGSKLVVLNNLKKMVN-------- 586
++L+ IP L +LQ ++L S LVVL+ ++
Sbjct: 172 NALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFD 231
Query: 587 ----LKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEII--------------- 627
L++L+L +L+ P +I +L+NL EL NN++++ E
Sbjct: 232 GLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDN 291
Query: 628 --------SFQHLQ-----------------------NLSCLKLWHNNIAYIPAQI-GAL 655
+FQHL NL L L I+ +P + L
Sbjct: 292 PIQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQL 351
Query: 656 SNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIP-EEIQYLSNLQYFAVTNNNI 714
NL+ L L +N +E+LP +C KL +DL +N + I + Q L +L+ + N I
Sbjct: 352 PNLQVLDLSYNLLEDLP-SFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKI 410
Query: 715 EMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNY 759
++ F L ++L++ P G L LTHL+L GN+
Sbjct: 411 AIIHPNAFSTLPSLIKLDLSSNLLSSFPITG-LHGLTHLKLTGNH 454
Score = 64.3 bits (155), Expect = 4e-10
Identities = 84/281 (29%), Positives = 127/281 (45%), Gaps = 53/281 (18%)
Query: 422 IELHLFMLNGLPDNVFE-LTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHP 480
+ LH ++ L F+ L +E L L + P+A+ L NLKEL +HS+ + P
Sbjct: 215 LHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELG-FHSNNIRSIP 273
Query: 481 ALAFLEENLKILRLKFTE--MGKIPRWVF-HLKNLKELYLSGCVLPEQLSTMQLEGFQDL 537
AF+ N ++ + F + + + R F HL L+ L L+G Q+ F DL
Sbjct: 274 EKAFVG-NPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGA--------SQITEFPDL 324
Query: 538 K---NLRTLYLKSS-LSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELI 593
NL +L L + +S +PQ V + LP+LQ L L NL
Sbjct: 325 TGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLS---------------YNL------ 363
Query: 594 SCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYI-PAQI 652
LE +P S L ++DLR N + + ++ +FQ L +L L L N IA I P
Sbjct: 364 ---LEDLP-SFSVCQKLQKIDLRHNEIYEI-KVDTFQQLLSLRSLNLAWNKIAIIHPNAF 418
Query: 653 GALSNLEQLSLDHNNIENLPLQLFLCTKLH---YLDLSYNH 690
L +L +L L N + + P+ T LH +L L+ NH
Sbjct: 419 STLPSLIKLDLSSNLLSSFPI-----TGLHGLTHLKLTGNH 454
>gi|33285015 leucine rich repeat containing 28 [Homo sapiens]
Length = 367
Score = 87.4 bits (215), Expect = 5e-17
Identities = 69/231 (29%), Positives = 115/231 (49%), Gaps = 7/231 (3%)
Query: 573 SKLVVLNNLKKMVNLKSLELISCDLERIPHSIFS---LNNLHELDLRENNLKTVEEIISF 629
S+L ++ ++ K+L L +L P + L L L ++ N+L ++ E ++
Sbjct: 3 SELCKTISVARLEKHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTSLPENLA- 61
Query: 630 QHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYN 689
Q L NL L L NNI +P IG+L L+ L L N +E + ++ L +L L+ N
Sbjct: 62 QKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANN 121
Query: 690 HLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSN 749
L F+P E+ L LQ ++ N + LP+ L C LQ L + +N L + H+ +L +
Sbjct: 122 QLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLPS 181
Query: 750 LTHLELIGNYLETLPPELEGCQSLKRNCLIVEENL-LNTLPLPVTERLQTC 799
L L + GN L LP +L + L+ + V+ N+ L LP + ++ C
Sbjct: 182 LNELSMAGNRLAFLPLDLGRSRELQ--YVYVDNNIHLKGLPSYLYNKVIGC 230
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 87.0 bits (214), Expect = 6e-17
Identities = 98/347 (28%), Positives = 150/347 (43%), Gaps = 44/347 (12%)
Query: 456 PSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKILRLKFTEMGKIPRWVF-HLKNLKE 514
P A L L++L V SS + + +L L L F + +P +F HL L+
Sbjct: 90 PDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALES 149
Query: 515 LYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSL-SRIPQVVTDLLPSLQKLSLDNEGS 573
L+L G QL + FQ L +L+TL L +L +++P+ + L SLQ L L N
Sbjct: 150 LHLQG----NQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNAL 205
Query: 574 KLVVLNNLKKMVNLKSLELISCDLERIPHSIFS-------------------------LN 608
+ K+ +L+ L L S ++ +P +FS L
Sbjct: 206 SGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLG 265
Query: 609 NLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGA-LSNLEQLSLDHNN 667
NL L L+ N L+ + + F H L L L HN + + A LSNL L L +N
Sbjct: 266 NLTFLSLQWNMLRVLPAGL-FAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNA 324
Query: 668 IENLPLQLFL-CTKLHYLDLSYNHLTFI-PEEIQYLSNLQYFAVTNNNIEMLPDGLFQCK 725
I +LP +F +L L L N+LT + P Q LS L+ +++ N + LP+G+F
Sbjct: 325 ITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDT- 383
Query: 726 KLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQS 772
+L NL+ H HL + N+L+ L Q+
Sbjct: 384 --------NYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQT 422
Score = 78.2 bits (191), Expect = 3e-14
Identities = 90/302 (29%), Positives = 137/302 (45%), Gaps = 39/302 (12%)
Query: 522 LPEQLSTMQLEGFQDLKNLRTLYLK-SSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNN 580
L QL + + F L L L + SS + + L SL KL+L+ + +
Sbjct: 81 LNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGL 140
Query: 581 LKKMVNLKSLELISCDLERIPHSIFS-LNNLHELDLRENNLKTVEEIISFQHLQNLSCLK 639
+ + L+SL L L+ +P +F L +L L+L +N L + E + F L +L LK
Sbjct: 141 FQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEEL-FHPLTSLQTLK 199
Query: 640 LWHNNIAYIPAQI-GALSNLEQLSLDHNNIENLPLQLF---LCTKLHYLDLSYNHLTFIP 695
L +N ++ +P + G L +L++L LD NNI LP Q+F C L L L N +T +P
Sbjct: 200 LSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFC--LERLWLQRNAITHLP 257
Query: 696 EEI-QYLSNLQYFAVTNNNIEMLPDGLF-------------------------QCKKLQC 729
I L NL + ++ N + +LP GLF L+
Sbjct: 258 LSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRS 317
Query: 730 LLLGKNSLMNLSPHV-GELSNLTHLELIGNYLETLPPELEGCQSL-KRNCLIVEENLLNT 787
L+L N++ +L + +L L L L N L L P L Q+L K L + +N L T
Sbjct: 318 LMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPAL--FQNLSKLELLSLSKNQLTT 375
Query: 788 LP 789
LP
Sbjct: 376 LP 377
>gi|21389431 leucine rich repeat containing 39 [Homo sapiens]
Length = 335
Score = 86.3 bits (212), Expect = 1e-16
Identities = 60/199 (30%), Positives = 91/199 (45%), Gaps = 26/199 (13%)
Query: 600 IPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLE 659
+P S+ LN L E L L + E I QNL L L N I+ IP IG L+ L+
Sbjct: 75 LPSSLLKLNQLQEWQLHRTGLLKIPEFIG--RFQNLIVLDLSRNTISEIPPGIGLLTRLQ 132
Query: 660 QLSLDHNNIENLPLQLFLCT------------------------KLHYLDLSYNHLTFIP 695
+L L +N I+ +P +L C KL +LDLS N T IP
Sbjct: 133 ELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIP 192
Query: 696 EEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLEL 755
+ + L++ + +N +E LPD + + + L L L +N + L + + NL L L
Sbjct: 193 LAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVL 252
Query: 756 IGNYLETLPPELEGCQSLK 774
N L+ +P +E +L+
Sbjct: 253 SNNKLQDIPVCMEEMANLR 271
Score = 76.6 bits (187), Expect = 8e-14
Identities = 63/210 (30%), Positives = 99/210 (47%), Gaps = 7/210 (3%)
Query: 560 LPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLRENN 619
L LQ+ L G L + + + NL L+L + IP I L L EL L N
Sbjct: 82 LNQLQEWQLHRTGL-LKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNK 140
Query: 620 LKTVEEIISFQHLQNLSCLKLWHN-NIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLC 678
+KTV + +S + +L L+L N +I +P ++ L L L L N+ +PL +
Sbjct: 141 IKTVPKELS--NCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNM 198
Query: 679 TKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLM 738
L +LD+ N L +P+ I+ + NL + N I LP + K L L+L N L
Sbjct: 199 PALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQ 258
Query: 739 NLSPHVGELSNLTHLELIGNYLE---TLPP 765
++ + E++NL + N L+ +LPP
Sbjct: 259 DIPVCMEEMANLRFVNFRDNPLKLKVSLPP 288
Score = 57.8 bits (138), Expect = 4e-08
Identities = 65/300 (21%), Positives = 137/300 (45%), Gaps = 44/300 (14%)
Query: 379 LYSKRFSIFLSEVSENKLKQINLNNEW----TVEKLKSKLVK-NAQDKIELHLFMLNGLP 433
++ KR ++ K Q L W ++ KL+ K+ + + + +++ LP
Sbjct: 17 VWEKRIKKLNEDLKREKEFQHKLVRIWEERVSLTKLREKVTREDGRVILKIEKEEWKTLP 76
Query: 434 DNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKILR 493
++ +L +++ L +K+P + + NL L + +++ P + L L+ L
Sbjct: 77 SSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLL-TRLQELI 135
Query: 494 LKFTEMGKIPRWVFHLKNLKELYLSG----CVLPEQLSTMQLEGFQDLKNLRTLYLKSSL 549
L + ++ +P+ + + +L++L L+ C LP++LS + L+ +L S+
Sbjct: 136 LSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNL----------LKLTHLDLSM 185
Query: 550 SRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNN 609
+ + L VLN M L+ L++ S LE++P +I + N
Sbjct: 186 NDFTTI------------------PLAVLN----MPALEWLDMGSNKLEQLPDTIERMQN 223
Query: 610 LHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIE 669
LH L L+ N + + + IS +++NL L L +N + IP + ++NL ++ N ++
Sbjct: 224 LHTLWLQRNEITCLPQTIS--NMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLK 281
Score = 46.2 bits (108), Expect = 1e-04
Identities = 28/104 (26%), Positives = 56/104 (53%), Gaps = 1/104 (0%)
Query: 694 IPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHL 753
+P + L+ LQ + + + +P+ + + + L L L +N++ + P +G L+ L L
Sbjct: 75 LPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQEL 134
Query: 754 ELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTLPLPVTERLQ 797
L N ++T+P EL C SL++ L V ++ + LP ++ L+
Sbjct: 135 ILSYNKIKTVPKELSNCASLEKLELAVNRDICD-LPQELSNLLK 177
Score = 45.4 bits (106), Expect = 2e-04
Identities = 38/133 (28%), Positives = 57/133 (42%), Gaps = 3/133 (2%)
Query: 661 LSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDG 720
L ++ + LP L +L L L IPE I NL ++ N I +P G
Sbjct: 65 LKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPG 124
Query: 721 LFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLEL-IGNYLETLPPELEGCQSLKRNCLI 779
+ +LQ L+L N + + + ++L LEL + + LP EL LK L
Sbjct: 125 IGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNL--LKLTHLD 182
Query: 780 VEENLLNTLPLPV 792
+ N T+PL V
Sbjct: 183 LSMNDFTTIPLAV 195
Score = 34.3 bits (77), Expect = 0.47
Identities = 44/170 (25%), Positives = 75/170 (44%), Gaps = 14/170 (8%)
Query: 391 VSENKLKQI--NLNNEWTVEKLKSKLVKNAQDKIELHLFMLNGLPDNVFELTEMEVLSLE 448
+S NK+K + L+N ++EKL+ + ++ D LP + L ++ L L
Sbjct: 136 LSYNKIKTVPKELSNCASLEKLELAVNRDICD-----------LPQELSNLLKLTHLDLS 184
Query: 449 LIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKILRLKFTEMGKIPRWVFH 508
+ +P AV + L+ L + S+ + P +NL L L+ E+ +P+ + +
Sbjct: 185 MNDFTTIPLAVLNMPALEWLDM-GSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISN 243
Query: 509 LKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSLSRIPQVVTD 558
+KNL L LS L + M+ N R LK +S P TD
Sbjct: 244 MKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPPSEGTD 293
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.137 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,433,704
Number of Sequences: 37866
Number of extensions: 1234533
Number of successful extensions: 5467
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 113
Number of HSP's successfully gapped in prelim test: 173
Number of HSP's that attempted gapping in prelim test: 3711
Number of HSP's gapped (non-prelim): 809
length of query: 803
length of database: 18,247,518
effective HSP length: 110
effective length of query: 693
effective length of database: 14,082,258
effective search space: 9759004794
effective search space used: 9759004794
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.