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Search of human proteins with 197313667
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|197313667 cell division cycle 7 [Homo sapiens]
(574 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|197313667 cell division cycle 7 [Homo sapiens] 1144 0.0
gi|197313665 cell division cycle 7 [Homo sapiens] 1144 0.0
gi|4502715 cell division cycle 7 [Homo sapiens] 1144 0.0
gi|4503097 casein kinase 2, alpha prime polypeptide [Homo sapiens] 71 3e-12
gi|4503095 casein kinase II alpha 1 subunit isoform a [Homo sapi... 68 3e-11
gi|29570791 casein kinase II alpha 1 subunit isoform a [Homo sap... 68 3e-11
gi|23199991 casein kinase 1 epsilon [Homo sapiens] 63 8e-10
gi|4503093 casein kinase 1 epsilon [Homo sapiens] 63 8e-10
gi|20544145 casein kinase 1, delta isoform 2 [Homo sapiens] 63 8e-10
gi|20149530 casein kinase 1, delta isoform 1 [Homo sapiens] 63 8e-10
gi|68303572 casein kinase 1, alpha 1 isoform 2 [Homo sapiens] 59 1e-08
gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens] 56 1e-07
gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens] 56 1e-07
gi|21624639 casein kinase 1, alpha 1-like [Homo sapiens] 55 1e-07
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] 55 2e-07
gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens] 55 2e-07
gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens] 55 2e-07
gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens] 55 2e-07
gi|114796630 homeodomain interacting protein kinase 3 isoform 2 ... 55 2e-07
gi|114796624 homeodomain interacting protein kinase 3 isoform 1 ... 55 2e-07
gi|169171014 PREDICTED: similar to homeodomain interacting prote... 55 2e-07
gi|172073175 microtubule associated serine/threonine kinase-like... 55 2e-07
gi|32698688 citron [Homo sapiens] 54 3e-07
gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo s... 54 3e-07
gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo ... 54 3e-07
gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo ... 54 3e-07
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 54 3e-07
gi|4758666 LATS homolog 1 [Homo sapiens] 54 3e-07
gi|45120119 microtubule associated serine/threonine kinase 1 [Ho... 54 4e-07
gi|4502743 cyclin-dependent kinase 7 [Homo sapiens] 54 4e-07
>gi|197313667 cell division cycle 7 [Homo sapiens]
Length = 574
Score = 1144 bits (2959), Expect = 0.0
Identities = 574/574 (100%), Positives = 574/574 (100%)
Query: 1 MEASLGIQMDEPMAFSPQRDRFQAEGSLKKNEQNFKLAGVKKDIEKLYEAVPQLSNVFKI 60
MEASLGIQMDEPMAFSPQRDRFQAEGSLKKNEQNFKLAGVKKDIEKLYEAVPQLSNVFKI
Sbjct: 1 MEASLGIQMDEPMAFSPQRDRFQAEGSLKKNEQNFKLAGVKKDIEKLYEAVPQLSNVFKI 60
Query: 61 EDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGV 120
EDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGV
Sbjct: 61 EDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGV 120
Query: 121 KYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKP 180
KYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKP
Sbjct: 121 KYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKP 180
Query: 181 SNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIPLSG 240
SNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIPLSG
Sbjct: 181 SNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIPLSG 240
Query: 241 PVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSSISH 300
PVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSSISH
Sbjct: 241 PVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSSISH 300
Query: 301 ESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDCYATDKVC 360
ESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDCYATDKVC
Sbjct: 301 ESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDCYATDKVC 360
Query: 361 SICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDD 420
SICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDD
Sbjct: 361 SICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDD 420
Query: 421 LTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQ 480
LTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQ
Sbjct: 421 LTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQ 480
Query: 481 GHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNEVPD 540
GHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNEVPD
Sbjct: 481 GHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNEVPD 540
Query: 541 EAYDLLDKLLDLNPASRITAEEALLHPFFKDMSL 574
EAYDLLDKLLDLNPASRITAEEALLHPFFKDMSL
Sbjct: 541 EAYDLLDKLLDLNPASRITAEEALLHPFFKDMSL 574
>gi|197313665 cell division cycle 7 [Homo sapiens]
Length = 574
Score = 1144 bits (2959), Expect = 0.0
Identities = 574/574 (100%), Positives = 574/574 (100%)
Query: 1 MEASLGIQMDEPMAFSPQRDRFQAEGSLKKNEQNFKLAGVKKDIEKLYEAVPQLSNVFKI 60
MEASLGIQMDEPMAFSPQRDRFQAEGSLKKNEQNFKLAGVKKDIEKLYEAVPQLSNVFKI
Sbjct: 1 MEASLGIQMDEPMAFSPQRDRFQAEGSLKKNEQNFKLAGVKKDIEKLYEAVPQLSNVFKI 60
Query: 61 EDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGV 120
EDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGV
Sbjct: 61 EDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGV 120
Query: 121 KYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKP 180
KYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKP
Sbjct: 121 KYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKP 180
Query: 181 SNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIPLSG 240
SNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIPLSG
Sbjct: 181 SNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIPLSG 240
Query: 241 PVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSSISH 300
PVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSSISH
Sbjct: 241 PVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSSISH 300
Query: 301 ESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDCYATDKVC 360
ESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDCYATDKVC
Sbjct: 301 ESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDCYATDKVC 360
Query: 361 SICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDD 420
SICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDD
Sbjct: 361 SICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDD 420
Query: 421 LTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQ 480
LTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQ
Sbjct: 421 LTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQ 480
Query: 481 GHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNEVPD 540
GHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNEVPD
Sbjct: 481 GHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNEVPD 540
Query: 541 EAYDLLDKLLDLNPASRITAEEALLHPFFKDMSL 574
EAYDLLDKLLDLNPASRITAEEALLHPFFKDMSL
Sbjct: 541 EAYDLLDKLLDLNPASRITAEEALLHPFFKDMSL 574
>gi|4502715 cell division cycle 7 [Homo sapiens]
Length = 574
Score = 1144 bits (2959), Expect = 0.0
Identities = 574/574 (100%), Positives = 574/574 (100%)
Query: 1 MEASLGIQMDEPMAFSPQRDRFQAEGSLKKNEQNFKLAGVKKDIEKLYEAVPQLSNVFKI 60
MEASLGIQMDEPMAFSPQRDRFQAEGSLKKNEQNFKLAGVKKDIEKLYEAVPQLSNVFKI
Sbjct: 1 MEASLGIQMDEPMAFSPQRDRFQAEGSLKKNEQNFKLAGVKKDIEKLYEAVPQLSNVFKI 60
Query: 61 EDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGV 120
EDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGV
Sbjct: 61 EDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGV 120
Query: 121 KYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKP 180
KYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKP
Sbjct: 121 KYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKP 180
Query: 181 SNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIPLSG 240
SNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIPLSG
Sbjct: 181 SNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIPLSG 240
Query: 241 PVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSSISH 300
PVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSSISH
Sbjct: 241 PVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSSISH 300
Query: 301 ESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDCYATDKVC 360
ESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDCYATDKVC
Sbjct: 301 ESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDCYATDKVC 360
Query: 361 SICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDD 420
SICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDD
Sbjct: 361 SICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDD 420
Query: 421 LTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQ 480
LTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQ
Sbjct: 421 LTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQ 480
Query: 481 GHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNEVPD 540
GHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNEVPD
Sbjct: 481 GHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNEVPD 540
Query: 541 EAYDLLDKLLDLNPASRITAEEALLHPFFKDMSL 574
EAYDLLDKLLDLNPASRITAEEALLHPFFKDMSL
Sbjct: 541 EAYDLLDKLLDLNPASRITAEEALLHPFFKDMSL 574
>gi|4503097 casein kinase 2, alpha prime polypeptide [Homo sapiens]
Length = 350
Score = 70.9 bits (172), Expect = 3e-12
Identities = 52/164 (31%), Positives = 82/164 (50%), Gaps = 13/164 (7%)
Query: 48 YEA-VPQLSNV--FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAE 104
YEA VP N +++ K+G G +S V+ A + + E++ +K L P +I E
Sbjct: 27 YEAHVPSWGNQDDYQLVRKLGRGKYSEVFEA---INITNNERVVVKILKPVKKK-KIKRE 82
Query: 105 LQCLTVAGGQDNVMGVKYCFRKNDHV----VIAMPYLEHESFLDILNSLSFQEVREYMLN 160
++ L G N+ +K D V + Y+ + F + L+ ++R YM
Sbjct: 83 VKILENLRGGTNI--IKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYE 140
Query: 161 LFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTH 204
L KAL H GI+HRDVKP N + + + KK L+D+GLA+ H
Sbjct: 141 LLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYH 184
Score = 42.0 bits (97), Expect = 0.002
Identities = 20/68 (29%), Positives = 34/68 (50%)
Query: 368 QQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQI 427
Q+ R + F+ PE+L ++DMWS G + S++ R PF+ D+ L +I
Sbjct: 187 QEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRI 246
Query: 428 MTIRGSRE 435
+ G+ E
Sbjct: 247 AKVLGTEE 254
Score = 38.1 bits (87), Expect = 0.022
Identities = 18/32 (56%), Positives = 23/32 (71%)
Query: 538 VPDEAYDLLDKLLDLNPASRITAEEALLHPFF 569
V EA DLLDKLL + R+TA+EA+ HP+F
Sbjct: 294 VSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325
>gi|4503095 casein kinase II alpha 1 subunit isoform a [Homo
sapiens]
Length = 391
Score = 67.8 bits (164), Expect = 3e-11
Identities = 41/149 (27%), Positives = 76/149 (51%), Gaps = 6/149 (4%)
Query: 58 FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNV 117
+++ K+G G +S V+ A + + EK+ +K L P +I E++ L G N+
Sbjct: 39 YQLVRKLGRGKYSEVFEA---INITNNEKVVVKILKPVKKK-KIKREIKILENLRGGPNI 94
Query: 118 MGVKYCFRK--NDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVH 175
+ + + + + ++ + F + +L+ ++R YM + KAL H GI+H
Sbjct: 95 ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMH 154
Query: 176 RDVKPSNFLYNRRLKKYALVDFGLAQGTH 204
RDVKP N + + +K L+D+GLA+ H
Sbjct: 155 RDVKPHNVMIDHEHRKLRLIDWGLAEFYH 183
Score = 39.3 bits (90), Expect = 0.010
Identities = 18/68 (26%), Positives = 34/68 (50%)
Query: 368 QQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQI 427
Q+ R + F+ PE+L ++DMWS G + S++ + PF+ D+ L +I
Sbjct: 186 QEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRI 245
Query: 428 MTIRGSRE 435
+ G+ +
Sbjct: 246 AKVLGTED 253
Score = 38.1 bits (87), Expect = 0.022
Identities = 19/37 (51%), Positives = 24/37 (64%)
Query: 533 EGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFF 569
E + V EA D LDKLL + SR+TA EA+ HP+F
Sbjct: 288 ENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
>gi|29570791 casein kinase II alpha 1 subunit isoform a [Homo
sapiens]
Length = 391
Score = 67.8 bits (164), Expect = 3e-11
Identities = 41/149 (27%), Positives = 76/149 (51%), Gaps = 6/149 (4%)
Query: 58 FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNV 117
+++ K+G G +S V+ A + + EK+ +K L P +I E++ L G N+
Sbjct: 39 YQLVRKLGRGKYSEVFEA---INITNNEKVVVKILKPVKKK-KIKREIKILENLRGGPNI 94
Query: 118 MGVKYCFRK--NDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVH 175
+ + + + + ++ + F + +L+ ++R YM + KAL H GI+H
Sbjct: 95 ITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMH 154
Query: 176 RDVKPSNFLYNRRLKKYALVDFGLAQGTH 204
RDVKP N + + +K L+D+GLA+ H
Sbjct: 155 RDVKPHNVMIDHEHRKLRLIDWGLAEFYH 183
Score = 39.3 bits (90), Expect = 0.010
Identities = 18/68 (26%), Positives = 34/68 (50%)
Query: 368 QQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQI 427
Q+ R + F+ PE+L ++DMWS G + S++ + PF+ D+ L +I
Sbjct: 186 QEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRI 245
Query: 428 MTIRGSRE 435
+ G+ +
Sbjct: 246 AKVLGTED 253
Score = 38.1 bits (87), Expect = 0.022
Identities = 19/37 (51%), Positives = 24/37 (64%)
Query: 533 EGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFF 569
E + V EA D LDKLL + SR+TA EA+ HP+F
Sbjct: 288 ENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324
>gi|23199991 casein kinase 1 epsilon [Homo sapiens]
Length = 416
Score = 62.8 bits (151), Expect = 8e-10
Identities = 44/162 (27%), Positives = 78/162 (48%), Gaps = 12/162 (7%)
Query: 53 QLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALK-HLIPTSHPIRIAAELQCLTVA 111
++ N +++ KIG G+F +YL + E++A+K + T HP ++ E + +
Sbjct: 4 RVGNKYRLGRKIGSGSFGDIYLGA---NIASGEEVAIKLECVKTKHP-QLHIESKFYKMM 59
Query: 112 GGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILN----SLSFQEVREYMLNLFKALKR 167
G + +K+C + D+ V+ M L S D+ N S + V + ++
Sbjct: 60 QGGVGIPSIKWCGAEGDYNVMVMELLG-PSLEDLFNFCSRKFSLKTVLLLADQMISRIEY 118
Query: 168 IHQFGIVHRDVKPSNFL--YNRRLKKYALVDFGLAQGTHDTK 207
IH +HRDVKP NFL ++ ++DFGLA+ D +
Sbjct: 119 IHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDAR 160
>gi|4503093 casein kinase 1 epsilon [Homo sapiens]
Length = 416
Score = 62.8 bits (151), Expect = 8e-10
Identities = 44/162 (27%), Positives = 78/162 (48%), Gaps = 12/162 (7%)
Query: 53 QLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALK-HLIPTSHPIRIAAELQCLTVA 111
++ N +++ KIG G+F +YL + E++A+K + T HP ++ E + +
Sbjct: 4 RVGNKYRLGRKIGSGSFGDIYLGA---NIASGEEVAIKLECVKTKHP-QLHIESKFYKMM 59
Query: 112 GGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILN----SLSFQEVREYMLNLFKALKR 167
G + +K+C + D+ V+ M L S D+ N S + V + ++
Sbjct: 60 QGGVGIPSIKWCGAEGDYNVMVMELLG-PSLEDLFNFCSRKFSLKTVLLLADQMISRIEY 118
Query: 168 IHQFGIVHRDVKPSNFL--YNRRLKKYALVDFGLAQGTHDTK 207
IH +HRDVKP NFL ++ ++DFGLA+ D +
Sbjct: 119 IHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDAR 160
>gi|20544145 casein kinase 1, delta isoform 2 [Homo sapiens]
Length = 409
Score = 62.8 bits (151), Expect = 8e-10
Identities = 44/162 (27%), Positives = 79/162 (48%), Gaps = 12/162 (7%)
Query: 53 QLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALK-HLIPTSHPIRIAAELQCLTVA 111
++ N +++ KIG G+F +YL T + E++A+K + T HP ++ E + +
Sbjct: 4 RVGNRYRLGRKIGSGSFGDIYLGT---DIAAGEEVAIKLECVKTKHP-QLHIESKIYKMM 59
Query: 112 GGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILN----SLSFQEVREYMLNLFKALKR 167
G + +++C + D+ V+ M L S D+ N S + V + ++
Sbjct: 60 QGGVGIPTIRWCGAEGDYNVMVMELLG-PSLEDLFNFCSRKFSLKTVLLLADQMISRIEY 118
Query: 168 IHQFGIVHRDVKPSNFL--YNRRLKKYALVDFGLAQGTHDTK 207
IH +HRDVKP NFL ++ ++DFGLA+ D +
Sbjct: 119 IHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDAR 160
>gi|20149530 casein kinase 1, delta isoform 1 [Homo sapiens]
Length = 415
Score = 62.8 bits (151), Expect = 8e-10
Identities = 44/162 (27%), Positives = 79/162 (48%), Gaps = 12/162 (7%)
Query: 53 QLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALK-HLIPTSHPIRIAAELQCLTVA 111
++ N +++ KIG G+F +YL T + E++A+K + T HP ++ E + +
Sbjct: 4 RVGNRYRLGRKIGSGSFGDIYLGT---DIAAGEEVAIKLECVKTKHP-QLHIESKIYKMM 59
Query: 112 GGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILN----SLSFQEVREYMLNLFKALKR 167
G + +++C + D+ V+ M L S D+ N S + V + ++
Sbjct: 60 QGGVGIPTIRWCGAEGDYNVMVMELLG-PSLEDLFNFCSRKFSLKTVLLLADQMISRIEY 118
Query: 168 IHQFGIVHRDVKPSNFL--YNRRLKKYALVDFGLAQGTHDTK 207
IH +HRDVKP NFL ++ ++DFGLA+ D +
Sbjct: 119 IHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDAR 160
>gi|68303572 casein kinase 1, alpha 1 isoform 2 [Homo sapiens]
Length = 337
Score = 58.9 bits (141), Expect = 1e-08
Identities = 42/156 (26%), Positives = 76/156 (48%), Gaps = 10/156 (6%)
Query: 58 FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNV 117
+K+ KIG G+F +YLA + + E++A+K + ++ E + + G +
Sbjct: 17 YKLVRKIGSGSFGDIYLA---INITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGI 73
Query: 118 MGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNL----FKALKRIHQFGI 173
+++ ++ D+ V+ M L S D+ N S + + +L L ++ +H
Sbjct: 74 PHIRWYGQEKDYNVLVMDLLG-PSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNF 132
Query: 174 VHRDVKPSNFL--YNRRLKKYALVDFGLAQGTHDTK 207
+HRD+KP NFL R K L+DFGLA+ D +
Sbjct: 133 IHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNR 168
>gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens]
Length = 1030
Score = 55.8 bits (133), Expect = 1e-07
Identities = 48/164 (29%), Positives = 81/164 (49%), Gaps = 21/164 (12%)
Query: 51 VPQLSNV---FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAA---- 103
+P + NV F+I +GEG + V + E +A+K + +
Sbjct: 3 IPNIGNVMNKFEILGVVGEGAYGVVLKCRHK---ETHEIVAIKKFKDSEENEEVKETTLR 59
Query: 104 ELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDIL----NSLSFQEVREYML 159
EL+ L Q+N++ +K FR+ + + Y+E ++ L++L N + ++V+ Y+
Sbjct: 60 ELKMLRTLK-QENIVELKEAFRRRGKLYLVFEYVE-KNMLELLEEMPNGVPPEKVKSYIY 117
Query: 160 NLFKALKRIHQFGIVHRDVKPSNFL--YNRRLKKYALVDFGLAQ 201
L KA+ H+ IVHRD+KP N L +N LK L DFG A+
Sbjct: 118 QLIKAIHWCHKNDIVHRDIKPENLLISHNDVLK---LCDFGFAR 158
Score = 31.2 bits (69), Expect = 2.7
Identities = 19/57 (33%), Positives = 28/57 (49%), Gaps = 2/57 (3%)
Query: 376 TPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRG 432
T +R+PE+L P ++DMWS G I L LS P + ++ L I + G
Sbjct: 174 TRWYRSPELLLGAP-YGKSVDMWSVGCI-LGELSDGQPLFPGESEIDQLFTIQKVLG 228
Score = 30.4 bits (67), Expect = 4.6
Identities = 14/31 (45%), Positives = 18/31 (58%)
Query: 544 DLLDKLLDLNPASRITAEEALLHPFFKDMSL 574
DL+ LL L+PA R E+ L HP F+ L
Sbjct: 272 DLMKNLLKLDPADRYLTEQCLNHPTFQTQRL 302
>gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens]
Length = 1030
Score = 55.8 bits (133), Expect = 1e-07
Identities = 48/164 (29%), Positives = 81/164 (49%), Gaps = 21/164 (12%)
Query: 51 VPQLSNV---FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAA---- 103
+P + NV F+I +GEG + V + E +A+K + +
Sbjct: 3 IPNIGNVMNKFEILGVVGEGAYGVVLKCRHK---ETHEIVAIKKFKDSEENEEVKETTLR 59
Query: 104 ELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDIL----NSLSFQEVREYML 159
EL+ L Q+N++ +K FR+ + + Y+E ++ L++L N + ++V+ Y+
Sbjct: 60 ELKMLRTLK-QENIVELKEAFRRRGKLYLVFEYVE-KNMLELLEEMPNGVPPEKVKSYIY 117
Query: 160 NLFKALKRIHQFGIVHRDVKPSNFL--YNRRLKKYALVDFGLAQ 201
L KA+ H+ IVHRD+KP N L +N LK L DFG A+
Sbjct: 118 QLIKAIHWCHKNDIVHRDIKPENLLISHNDVLK---LCDFGFAR 158
Score = 31.2 bits (69), Expect = 2.7
Identities = 19/57 (33%), Positives = 28/57 (49%), Gaps = 2/57 (3%)
Query: 376 TPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRG 432
T +R+PE+L P ++DMWS G I L LS P + ++ L I + G
Sbjct: 174 TRWYRSPELLLGAP-YGKSVDMWSVGCI-LGELSDGQPLFPGESEIDQLFTIQKVLG 228
Score = 30.4 bits (67), Expect = 4.6
Identities = 14/31 (45%), Positives = 18/31 (58%)
Query: 544 DLLDKLLDLNPASRITAEEALLHPFFKDMSL 574
DL+ LL L+PA R E+ L HP F+ L
Sbjct: 272 DLMKNLLKLDPADRYLTEQCLNHPTFQTQRL 302
>gi|21624639 casein kinase 1, alpha 1-like [Homo sapiens]
Length = 337
Score = 55.5 bits (132), Expect = 1e-07
Identities = 45/156 (28%), Positives = 73/156 (46%), Gaps = 10/156 (6%)
Query: 58 FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNV 117
+K+ KIG G+F VYL G E + L+ HP ++ E + T+ G +
Sbjct: 17 YKLVRKIGSGSFGDVYLGITTTN-GEEVAVKLESQ-KVKHP-QLLYESKLYTILQGGVGI 73
Query: 118 MGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNL----FKALKRIHQFGI 173
+ + ++ D+ V+ M L S D+ N S + + +L L ++ +H
Sbjct: 74 PHMHWYGQEKDNNVLVMDLLG-PSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNF 132
Query: 174 VHRDVKPSNFLY--NRRLKKYALVDFGLAQGTHDTK 207
+HRD+KP NFL R K L+DFGLA+ D +
Sbjct: 133 LHRDIKPDNFLMGTGRHCNKLFLIDFGLAKKYRDNR 168
>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
Length = 745
Score = 55.1 bits (131), Expect = 2e-07
Identities = 57/215 (26%), Positives = 97/215 (45%), Gaps = 18/215 (8%)
Query: 6 GIQM-DEPMAFSPQRDRFQAEGSLKKNEQNFKLAGVKKDIEKLYEAVPQLSNVFKIEDKI 64
G++M DEPM + D EG +K+ VK+ EK A +L V +
Sbjct: 30 GLKMVDEPME-EGEADSCHDEGVVKEIPITHH---VKEGYEKADPAQFELLKV------L 79
Query: 65 GEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQC---LTVAGGQDNVMGVK 121
G+G+F V+L + + A+K L S +R + + V ++ +
Sbjct: 80 GQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVNHPFIVKLH 139
Query: 122 YCFRKNDHVVIAMPYLEH-ESFLDILNSLSFQE--VREYMLNLFKALKRIHQFGIVHRDV 178
Y F+ + + + +L + F + + F E V+ Y+ L AL +HQ GIV+RD+
Sbjct: 140 YAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDL 199
Query: 179 KPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKF 213
KP N L + + L DFGL++ + D + + F
Sbjct: 200 KPENILLD-EIGHIKLTDFGLSKESVDQEKKAYSF 233
Score = 46.6 bits (109), Expect = 6e-05
Identities = 38/155 (24%), Positives = 72/155 (46%), Gaps = 11/155 (7%)
Query: 53 QLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAG 112
Q V+++++ IG G++S + + + A+K + + + E++ L G
Sbjct: 421 QFGEVYELKEDIGVGSYS---VCKRCIHATTNMEFAVKIIDKSKRDP--SEEIEILMRYG 475
Query: 113 GQDNVMGVKYCFRKNDHVVIAMPYLEHESFLD-ILNSLSF--QEVREYMLNLFKALKRIH 169
N++ +K F +V + ++ LD IL F +E + + + K + +H
Sbjct: 476 QHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLH 535
Query: 170 QFGIVHRDVKPSNFLY---NRRLKKYALVDFGLAQ 201
G+VHRD+KPSN LY + + DFG A+
Sbjct: 536 CQGVVHRDLKPSNILYMDESASADSIRICDFGFAK 570
Score = 37.0 bits (84), Expect = 0.049
Identities = 19/45 (42%), Positives = 26/45 (57%), Gaps = 1/45 (2%)
Query: 376 TPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDD 420
T F APEVL + A D+WS GV+F ++L+G PF +D
Sbjct: 585 TANFVAPEVLMQ-QGYDAACDIWSLGVLFYTMLAGYTPFANGPND 628
Score = 33.5 bits (75), Expect = 0.54
Identities = 14/32 (43%), Positives = 20/32 (62%)
Query: 535 WNEVPDEAYDLLDKLLDLNPASRITAEEALLH 566
W+ + D A DLL +L ++P R TAE+ L H
Sbjct: 649 WDNISDGAKDLLSHMLHMDPHQRYTAEQILKH 680
Score = 33.1 bits (74), Expect = 0.71
Identities = 16/40 (40%), Positives = 24/40 (60%), Gaps = 1/40 (2%)
Query: 375 GTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPF 414
GT + APEV+ + + +A D WS GV+ +L+G PF
Sbjct: 235 GTVEYMAPEVVNRRGHSQSA-DWWSYGVLMFEMLTGTLPF 273
>gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens]
Length = 504
Score = 55.1 bits (131), Expect = 2e-07
Identities = 47/150 (31%), Positives = 74/150 (49%), Gaps = 19/150 (12%)
Query: 62 DKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHP-------IRIAAELQCLTVAGGQ 114
DK+GEGT+++V+ ++L E +ALK I H IR + L+ L A
Sbjct: 178 DKLGEGTYATVFKGRSKLT---ENLVALKE-IRLEHEEGAPCTAIREVSLLKNLKHA--- 230
Query: 115 DNVMGVKYCFRKNDHVVIAMPYLEHE--SFLDIL-NSLSFQEVREYMLNLFKALKRIHQF 171
N++ + + + + YL+ + +LD N +S V+ +M L + L H
Sbjct: 231 -NIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHR 289
Query: 172 GIVHRDVKPSNFLYNRRLKKYALVDFGLAQ 201
I+HRD+KP N L N R + L DFGLA+
Sbjct: 290 KILHRDLKPQNLLINER-GELKLADFGLAR 318
Score = 32.3 bits (72), Expect = 1.2
Identities = 18/55 (32%), Positives = 26/55 (47%), Gaps = 1/55 (1%)
Query: 379 FRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGS 433
+R P+VL +T IDMW G I + +GR P + S L I + G+
Sbjct: 336 YRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGR-PLFPGSTVKEELHLIFRLLGT 389
>gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
Length = 474
Score = 55.1 bits (131), Expect = 2e-07
Identities = 47/150 (31%), Positives = 74/150 (49%), Gaps = 19/150 (12%)
Query: 62 DKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHP-------IRIAAELQCLTVAGGQ 114
DK+GEGT+++V+ ++L E +ALK I H IR + L+ L A
Sbjct: 148 DKLGEGTYATVFKGRSKLT---ENLVALKE-IRLEHEEGAPCTAIREVSLLKNLKHA--- 200
Query: 115 DNVMGVKYCFRKNDHVVIAMPYLEHE--SFLDIL-NSLSFQEVREYMLNLFKALKRIHQF 171
N++ + + + + YL+ + +LD N +S V+ +M L + L H
Sbjct: 201 -NIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHR 259
Query: 172 GIVHRDVKPSNFLYNRRLKKYALVDFGLAQ 201
I+HRD+KP N L N R + L DFGLA+
Sbjct: 260 KILHRDLKPQNLLINER-GELKLADFGLAR 288
Score = 32.3 bits (72), Expect = 1.2
Identities = 18/55 (32%), Positives = 26/55 (47%), Gaps = 1/55 (1%)
Query: 379 FRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGS 433
+R P+VL +T IDMW G I + +GR P + S L I + G+
Sbjct: 306 YRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGR-PLFPGSTVKEELHLIFRLLGT 359
>gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
Length = 474
Score = 55.1 bits (131), Expect = 2e-07
Identities = 47/150 (31%), Positives = 74/150 (49%), Gaps = 19/150 (12%)
Query: 62 DKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHP-------IRIAAELQCLTVAGGQ 114
DK+GEGT+++V+ ++L E +ALK I H IR + L+ L A
Sbjct: 148 DKLGEGTYATVFKGRSKLT---ENLVALKE-IRLEHEEGAPCTAIREVSLLKNLKHA--- 200
Query: 115 DNVMGVKYCFRKNDHVVIAMPYLEHE--SFLDIL-NSLSFQEVREYMLNLFKALKRIHQF 171
N++ + + + + YL+ + +LD N +S V+ +M L + L H
Sbjct: 201 -NIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHR 259
Query: 172 GIVHRDVKPSNFLYNRRLKKYALVDFGLAQ 201
I+HRD+KP N L N R + L DFGLA+
Sbjct: 260 KILHRDLKPQNLLINER-GELKLADFGLAR 288
Score = 32.3 bits (72), Expect = 1.2
Identities = 18/55 (32%), Positives = 26/55 (47%), Gaps = 1/55 (1%)
Query: 379 FRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGS 433
+R P+VL +T IDMW G I + +GR P + S L I + G+
Sbjct: 306 YRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGR-PLFPGSTVKEELHLIFRLLGT 359
>gi|114796630 homeodomain interacting protein kinase 3 isoform 2
[Homo sapiens]
Length = 1194
Score = 55.1 bits (131), Expect = 2e-07
Identities = 45/184 (24%), Positives = 83/184 (45%), Gaps = 23/184 (12%)
Query: 48 YEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHP-------IR 100
+E + + N +++ D +G GTF V + G E +A+K L +HP I
Sbjct: 187 HEVLCSMKNTYEVLDFLGRGTFGQVVKCWKR---GTNEIVAIKIL--KNHPSYARQGQIE 241
Query: 101 IAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQE-----VR 155
++ + T + N + CF+ +H + LE ++ D L F +R
Sbjct: 242 VSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLE-QNLYDFLKQNKFSPLPLKVIR 300
Query: 156 EYMLNLFKALKRIHQFGIVHRDVKPSNFLY---NRRLKKYALVDFGLAQGTHDTKIELLK 212
+ + ALK++ G++H D+KP N + R+ + ++DFG A +H +K
Sbjct: 301 PILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSA--SHVSKTVCST 358
Query: 213 FVQS 216
++QS
Sbjct: 359 YLQS 362
Score = 32.0 bits (71), Expect = 1.6
Identities = 23/79 (29%), Positives = 34/79 (43%), Gaps = 12/79 (15%)
Query: 354 YATDKVCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYP 413
+ + VCS L R +RAPE++ P AIDMWS G + L G +P
Sbjct: 350 HVSKTVCSTYLQSRY----------YRAPEIILGLPF-CEAIDMWSLGCVIAELFLG-WP 397
Query: 414 FYKASDDLTALAQIMTIRG 432
Y + + + I +G
Sbjct: 398 LYPGALEYDQIRYISQTQG 416
>gi|114796624 homeodomain interacting protein kinase 3 isoform 1
[Homo sapiens]
Length = 1215
Score = 55.1 bits (131), Expect = 2e-07
Identities = 45/184 (24%), Positives = 83/184 (45%), Gaps = 23/184 (12%)
Query: 48 YEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHP-------IR 100
+E + + N +++ D +G GTF V + G E +A+K L +HP I
Sbjct: 187 HEVLCSMKNTYEVLDFLGRGTFGQVVKCWKR---GTNEIVAIKIL--KNHPSYARQGQIE 241
Query: 101 IAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQE-----VR 155
++ + T + N + CF+ +H + LE ++ D L F +R
Sbjct: 242 VSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLE-QNLYDFLKQNKFSPLPLKVIR 300
Query: 156 EYMLNLFKALKRIHQFGIVHRDVKPSNFLY---NRRLKKYALVDFGLAQGTHDTKIELLK 212
+ + ALK++ G++H D+KP N + R+ + ++DFG A +H +K
Sbjct: 301 PILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSA--SHVSKTVCST 358
Query: 213 FVQS 216
++QS
Sbjct: 359 YLQS 362
Score = 32.0 bits (71), Expect = 1.6
Identities = 23/79 (29%), Positives = 34/79 (43%), Gaps = 12/79 (15%)
Query: 354 YATDKVCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYP 413
+ + VCS L R +RAPE++ P AIDMWS G + L G +P
Sbjct: 350 HVSKTVCSTYLQSRY----------YRAPEIILGLPF-CEAIDMWSLGCVIAELFLG-WP 397
Query: 414 FYKASDDLTALAQIMTIRG 432
Y + + + I +G
Sbjct: 398 LYPGALEYDQIRYISQTQG 416
>gi|169171014 PREDICTED: similar to homeodomain interacting protein
kinase 2 [Homo sapiens]
Length = 460
Score = 54.7 bits (130), Expect = 2e-07
Identities = 44/193 (22%), Positives = 87/193 (45%), Gaps = 23/193 (11%)
Query: 48 YEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHP-------IR 100
+E + ++N +++ + +G GTF V + G E +A+K L +HP I
Sbjct: 189 HEVLCSMTNTYEVLEFLGRGTFGQVVKCWKR---GTNEIVAIKIL--KNHPSYARQGQIE 243
Query: 101 IAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQE-----VR 155
++ + T + N + CF+ +H + LE ++ D L F +R
Sbjct: 244 VSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLE-QNLYDFLKQNKFSPLPLKYIR 302
Query: 156 EYMLNLFKALKRIHQFGIVHRDVKPSNFLY---NRRLKKYALVDFGLAQGTHDTKIELLK 212
+ + AL ++ G++H D+KP N + +R+ + ++DFG A +H +K
Sbjct: 303 PVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSA--SHVSKAVCST 360
Query: 213 FVQSEAQQERCSQ 225
++QS + R +
Sbjct: 361 YLQSRYYRPRADR 373
>gi|172073175 microtubule associated serine/threonine kinase-like
[Homo sapiens]
Length = 878
Score = 54.7 bits (130), Expect = 2e-07
Identities = 42/177 (23%), Positives = 80/177 (45%), Gaps = 5/177 (2%)
Query: 38 AGVKKDIEKLYEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSH 97
A ++ + ++ P F I I G F VYL ++ + + +I +
Sbjct: 15 AATEEGVNRIAVPKPPSIEEFSIVKPISRGAFGKVYLGQKGGKLYAVKVVKKADMINKNM 74
Query: 98 PIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYL---EHESFLDILNSLSFQEV 154
++ AE L ++ ++ + Y + ++V + M YL + +S L I +
Sbjct: 75 THQVQAERDALALSKSPF-IVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMA 133
Query: 155 REYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELL 211
+Y+ + AL +H+ GI+HRD+KP N L + L DFGL++ T + I ++
Sbjct: 134 VKYISEVALALDYLHRHGIIHRDLKPDNMLISNE-GHIKLTDFGLSKVTLNRDINMM 189
Score = 37.7 bits (86), Expect = 0.029
Identities = 47/174 (27%), Positives = 73/174 (41%), Gaps = 18/174 (10%)
Query: 248 QQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSSISHES-PAVK 306
Q+ T+ V+ P Q G E L+ +R+ R+FN H + S+ S P+
Sbjct: 615 QEKTSPKGVENPAVQESNQKMLGPP-LEVLKTLASKRNAVAFRSFNSHINASNNSEPSRM 673
Query: 307 LMKQSKTVDVLSRKLATKKKAIS-TKVMNSAVMRKTASSCPASLTCDCYATDKVCSICLS 365
M +D+ + AI+ T+ S + +T + + Y T K S
Sbjct: 674 NMTSLDAMDISCAYSGSYPMAITPTQKRRSCMPHQTPNQIKSGTP---YRTPK------S 724
Query: 366 RRQQVAPR-----AGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPF 414
R+ VAP GTP + APE+L + A+D W+ GV L+G PF
Sbjct: 725 VRRGVAPVDDGRILGTPDYLAPELLLGRAHGP-AVDWWALGVCLFEFLTGIPPF 777
>gi|32698688 citron [Homo sapiens]
Length = 2027
Score = 54.3 bits (129), Expect = 3e-07
Identities = 44/173 (25%), Positives = 74/173 (42%), Gaps = 13/173 (7%)
Query: 44 IEKLYEAVPQLSNVFKIEDKIGEGTFSSVYL----ATAQLQVGPEEKIALKHLIPTSHPI 99
I +L E P + F++ +G G F+ V + AT + K+ K + +
Sbjct: 84 IAELQELQPSAKD-FEVRSLVGCGHFAEVQVVREKATGDIYA---MKVMKKKALLAQEQV 139
Query: 100 RIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILN----SLSFQEVR 155
E + + + ++Y F+ +H+ + M Y L +LN L ++
Sbjct: 140 SFFEEERNILSRSTSPWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQ 199
Query: 156 EYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKI 208
Y+ L A+ +H G VHRD+KP N L + R LVDFG A + K+
Sbjct: 200 FYLAELILAVHSVHLMGYVHRDIKPENILVD-RTGHIKLVDFGSAAKMNSNKM 251
Score = 35.0 bits (79), Expect = 0.19
Identities = 20/53 (37%), Positives = 25/53 (47%), Gaps = 5/53 (9%)
Query: 375 GTPGFRAPEVLTKCPNQTTAI-----DMWSAGVIFLSLLSGRYPFYKASDDLT 422
GTP + APEVLT D WS GVI ++ GR PF + + T
Sbjct: 259 GTPDYMAPEVLTVMNGDGKGTYGLDCDWWSVGVIAYEMIYGRSPFAEGTSART 311
>gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 54.3 bits (129), Expect = 3e-07
Identities = 43/168 (25%), Positives = 81/168 (48%), Gaps = 19/168 (11%)
Query: 48 YEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPI-----RIA 102
++ + + ++I + IG G + V A +L +++A+K IP + + R
Sbjct: 45 FDVTFDVGDEYEIIETIGNGAYGVVSSARRRLT---GQQVAIKK-IPNAFDVVTNAKRTL 100
Query: 103 AELQCLTVAGGQDNVMGVKYCFR--------KNDHVVIAMPYLEHESFLDILNSLSFQEV 154
EL+ L DN++ +K R K+ +VV+ + + + L+ + V
Sbjct: 101 RELKILKHFK-HDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHV 159
Query: 155 REYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQG 202
R ++ L + LK +H ++HRD+KPSN L N + + DFG+A+G
Sbjct: 160 RYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENC-ELKIGDFGMARG 206
Score = 35.8 bits (81), Expect = 0.11
Identities = 17/39 (43%), Positives = 23/39 (58%)
Query: 376 TPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPF 414
T +RAPE++ T AID+WS G IF +L+ R F
Sbjct: 224 TRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLF 262
>gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 54.3 bits (129), Expect = 3e-07
Identities = 43/168 (25%), Positives = 81/168 (48%), Gaps = 19/168 (11%)
Query: 48 YEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPI-----RIA 102
++ + + ++I + IG G + V A +L +++A+K IP + + R
Sbjct: 45 FDVTFDVGDEYEIIETIGNGAYGVVSSARRRLT---GQQVAIKK-IPNAFDVVTNAKRTL 100
Query: 103 AELQCLTVAGGQDNVMGVKYCFR--------KNDHVVIAMPYLEHESFLDILNSLSFQEV 154
EL+ L DN++ +K R K+ +VV+ + + + L+ + V
Sbjct: 101 RELKILKHFK-HDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHV 159
Query: 155 REYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQG 202
R ++ L + LK +H ++HRD+KPSN L N + + DFG+A+G
Sbjct: 160 RYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENC-ELKIGDFGMARG 206
Score = 35.8 bits (81), Expect = 0.11
Identities = 17/39 (43%), Positives = 23/39 (58%)
Query: 376 TPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPF 414
T +RAPE++ T AID+WS G IF +L+ R F
Sbjct: 224 TRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLF 262
>gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 54.3 bits (129), Expect = 3e-07
Identities = 43/168 (25%), Positives = 81/168 (48%), Gaps = 19/168 (11%)
Query: 48 YEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPI-----RIA 102
++ + + ++I + IG G + V A +L +++A+K IP + + R
Sbjct: 45 FDVTFDVGDEYEIIETIGNGAYGVVSSARRRLT---GQQVAIKK-IPNAFDVVTNAKRTL 100
Query: 103 AELQCLTVAGGQDNVMGVKYCFR--------KNDHVVIAMPYLEHESFLDILNSLSFQEV 154
EL+ L DN++ +K R K+ +VV+ + + + L+ + V
Sbjct: 101 RELKILKHFK-HDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHV 159
Query: 155 REYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQG 202
R ++ L + LK +H ++HRD+KPSN L N + + DFG+A+G
Sbjct: 160 RYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENC-ELKIGDFGMARG 206
Score = 35.8 bits (81), Expect = 0.11
Identities = 17/39 (43%), Positives = 23/39 (58%)
Query: 376 TPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPF 414
T +RAPE++ T AID+WS G IF +L+ R F
Sbjct: 224 TRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLF 262
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 54.3 bits (129), Expect = 3e-07
Identities = 51/174 (29%), Positives = 82/174 (47%), Gaps = 15/174 (8%)
Query: 41 KKDIEKLYE--AVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHP 98
++ ++KL E Q VF + +K+GEG++ SVY A + + G + +A+K + S
Sbjct: 11 RRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHK-ETG--QIVAIKQVPVESDL 67
Query: 99 IRIAAELQCLTVAGGQDNVMGVKY--CFRKNDHVVIAMPYLEHESFLDILN----SLSFQ 152
I E+ + D+ VKY + KN + I M Y S DI+ +L+
Sbjct: 68 QEIIKEISIMQQC---DSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTED 124
Query: 153 EVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDT 206
E+ + + K L+ +H +HRD+K N L N L DFG+A DT
Sbjct: 125 EIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTE-GHAKLADFGVAGQLTDT 177
>gi|4758666 LATS homolog 1 [Homo sapiens]
Length = 1130
Score = 54.3 bits (129), Expect = 3e-07
Identities = 44/152 (28%), Positives = 71/152 (46%), Gaps = 10/152 (6%)
Query: 64 IGEGTFSSVYLATA--QLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGVK 121
+G G F V LA + + + K ++ + + AE L A + V+ +
Sbjct: 711 LGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEW-VVRLY 769
Query: 122 YCFRKNDHVVIAMPYLEHESFLDILNSLS-FQE--VREYMLNLFKALKRIHQFGIVHRDV 178
Y F+ D++ M Y+ + +L + F E R Y+ L A++ +H+ G +HRD+
Sbjct: 770 YSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGFIHRDI 829
Query: 179 KPSNFLYNRRLKKYALVDFGLAQG---THDTK 207
KP N L +R L DFGL G THD+K
Sbjct: 830 KPDNILIDRD-GHIKLTDFGLCTGFRWTHDSK 860
Score = 37.7 bits (86), Expect = 0.029
Identities = 19/40 (47%), Positives = 23/40 (57%), Gaps = 1/40 (2%)
Query: 375 GTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPF 414
GTP + APEVL + T D WS GVI +L G+ PF
Sbjct: 912 GTPNYIAPEVLLRT-GYTQLCDWWSVGVILFEMLVGQPPF 950
>gi|45120119 microtubule associated serine/threonine kinase 1 [Homo
sapiens]
Length = 1570
Score = 53.9 bits (128), Expect = 4e-07
Identities = 46/155 (29%), Positives = 70/155 (45%), Gaps = 7/155 (4%)
Query: 52 PQLSNVFKIEDKIGEGTFSSVYLATAQ--LQVGPEEKIALKHLIPTSHPIRIAAELQCLT 109
P N F I G + +VYL + Q +KI ++LI + + E LT
Sbjct: 368 PPGENDFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILT 427
Query: 110 VAGGQDNVMGVKYCFRKNDHVVIAMPYLEH---ESFLDILNSLSFQEVREYMLNLFKALK 166
A V+G+ F H+ + M Y+E + L + +L + R Y AL+
Sbjct: 428 FAENPF-VVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLALE 486
Query: 167 RIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQ 201
+H +GIVHRD+KP N L + L DFGL++
Sbjct: 487 YLHNYGIVHRDLKPDNLLIT-SMGHIKLTDFGLSK 520
Score = 32.3 bits (72), Expect = 1.2
Identities = 15/41 (36%), Positives = 22/41 (53%), Gaps = 1/41 (2%)
Query: 375 GTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFY 415
GTP + APEV+ + +D W+ G+I L G PF+
Sbjct: 549 GTPEYIAPEVILR-QGYGKPVDWWAMGIILYEFLVGCVPFF 588
>gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]
Length = 346
Score = 53.9 bits (128), Expect = 4e-07
Identities = 43/147 (29%), Positives = 74/147 (50%), Gaps = 9/147 (6%)
Query: 62 DKIGEGTFSSVYLATAQL--QVGPEEKIALKHLIPTSHPIRIAA--ELQCLTVAGGQDNV 117
D +GEG F++VY A + Q+ +KI L H I A E++ L N+
Sbjct: 16 DFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS-HPNI 74
Query: 118 MGVKYCFRKNDHVVIAMPYLEHESFLDILNS---LSFQEVREYMLNLFKALKRIHQFGIV 174
+G+ F ++ + ++E + + I ++ L+ ++ YML + L+ +HQ I+
Sbjct: 75 IGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWIL 134
Query: 175 HRDVKPSNFLYNRRLKKYALVDFGLAQ 201
HRD+KP+N L + L DFGLA+
Sbjct: 135 HRDLKPNNLLLDEN-GVLKLADFGLAK 160
Score = 36.2 bits (82), Expect = 0.084
Identities = 21/58 (36%), Positives = 27/58 (46%), Gaps = 1/58 (1%)
Query: 376 TPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGS 433
T +RAPE+L +DMW+ G I LL R PF DL L +I G+
Sbjct: 175 TRWYRAPELLFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGT 231
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.131 0.377
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,358,314
Number of Sequences: 37866
Number of extensions: 930265
Number of successful extensions: 4141
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 375
Number of HSP's successfully gapped in prelim test: 248
Number of HSP's that attempted gapping in prelim test: 2728
Number of HSP's gapped (non-prelim): 1440
length of query: 574
length of database: 18,247,518
effective HSP length: 108
effective length of query: 466
effective length of database: 14,157,990
effective search space: 6597623340
effective search space used: 6597623340
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.