Guide to the Human Genome
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Search of human proteins with 19718759

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|19718759 myoferlin isoform b [Homo sapiens]
         (2048 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|19718759 myoferlin isoform b [Homo sapiens]                       4199   0.0  
gi|7305053 myoferlin isoform a [Homo sapiens]                        4189   0.0  
gi|195976777 dysferlin isoform 3 [Homo sapiens]                      2388   0.0  
gi|195976773 dysferlin isoform 5 [Homo sapiens]                      2385   0.0  
gi|195976754 dysferlin isoform 9 [Homo sapiens]                      2383   0.0  
gi|195976821 dysferlin isoform 2 [Homo sapiens]                      2382   0.0  
gi|195976775 dysferlin isoform 4 [Homo sapiens]                      2380   0.0  
gi|195976756 dysferlin isoform 10 [Homo sapiens]                     2380   0.0  
gi|195976769 dysferlin isoform 6 [Homo sapiens]                      2379   0.0  
gi|4503431 dysferlin isoform 8 [Homo sapiens]                        2377   0.0  
gi|195976779 dysferlin isoform 1 [Homo sapiens]                      2377   0.0  
gi|195976762 dysferlin isoform 13 [Homo sapiens]                     2374   0.0  
gi|195976766 dysferlin isoform 7 [Homo sapiens]                      2374   0.0  
gi|195976758 dysferlin isoform 11 [Homo sapiens]                     2374   0.0  
gi|195976764 dysferlin isoform 14 [Homo sapiens]                     2371   0.0  
gi|195976760 dysferlin isoform 12 [Homo sapiens]                     2368   0.0  
gi|164607133 fer-1-like 5 isoform 2 [Homo sapiens]                   1526   0.0  
gi|116642865 fer-1-like 5 isoform 1 [Homo sapiens]                    718   0.0  
gi|119120884 fer-1-like 6 [Homo sapiens]                              689   0.0  
gi|35493868 otoferlin isoform b [Homo sapiens]                        688   0.0  
gi|35493853 otoferlin isoform c [Homo sapiens]                        684   0.0  
gi|34740331 otoferlin isoform a [Homo sapiens]                        684   0.0  
gi|35493860 otoferlin isoform d [Homo sapiens]                        681   0.0  
gi|238550198 synaptotagmin III [Homo sapiens]                          62   6e-09
gi|238550196 synaptotagmin III [Homo sapiens]                          62   6e-09
gi|14150054 synaptotagmin III [Homo sapiens]                           62   6e-09
gi|194294523 intersectin 2 isoform 3 [Homo sapiens]                    60   3e-08
gi|194294521 intersectin 2 isoform 1 [Homo sapiens]                    60   3e-08
gi|50582996 multiple C2 domains, transmembrane 1 isoform S [Homo...    57   2e-07
gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Hom...    57   2e-07

>gi|19718759 myoferlin isoform b [Homo sapiens]
          Length = 2048

 Score = 4199 bits (10889), Expect = 0.0
 Identities = 2048/2048 (100%), Positives = 2048/2048 (100%)

Query: 1    MLRVIVESASNIPKTKFGKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLD 60
            MLRVIVESASNIPKTKFGKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLD
Sbjct: 1    MLRVIVESASNIPKTKFGKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLD 60

Query: 61   FSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKGQDTGATIDL 120
            FSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKGQDTGATIDL
Sbjct: 61   FSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKGQDTGATIDL 120

Query: 121  VIGYDPPSAPHPNDLSGPSVPGMGGDGEEDEGDEDRLDNAVRGPGPKGPVGTVSEAQLAR 180
            VIGYDPPSAPHPNDLSGPSVPGMGGDGEEDEGDEDRLDNAVRGPGPKGPVGTVSEAQLAR
Sbjct: 121  VIGYDPPSAPHPNDLSGPSVPGMGGDGEEDEGDEDRLDNAVRGPGPKGPVGTVSEAQLAR 180

Query: 181  RLTKVKNSRRMLSNKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNNPF 240
            RLTKVKNSRRMLSNKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNNPF
Sbjct: 181  RLTKVKNSRRMLSNKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNNPF 240

Query: 241  FDELFFYNVNMTPSELMDEIISIRVYNSHSLRADCLMGEFKIDVGFVYDEPGHAVMRKWL 300
            FDELFFYNVNMTPSELMDEIISIRVYNSHSLRADCLMGEFKIDVGFVYDEPGHAVMRKWL
Sbjct: 241  FDELFFYNVNMTPSELMDEIISIRVYNSHSLRADCLMGEFKIDVGFVYDEPGHAVMRKWL 300

Query: 301  LLNDPEDTSSGSKGYMKVSMFVLGTGDEPPPERRDRDNDSDDVESNLLLPAGIALRWVTF 360
            LLNDPEDTSSGSKGYMKVSMFVLGTGDEPPPERRDRDNDSDDVESNLLLPAGIALRWVTF
Sbjct: 301  LLNDPEDTSSGSKGYMKVSMFVLGTGDEPPPERRDRDNDSDDVESNLLLPAGIALRWVTF 360

Query: 361  LLKIYRAEDIPQMDDAFSQTVKEIFGGNADKKNLVDPFVEVSFAGKKVCTNIIEKNANPE 420
            LLKIYRAEDIPQMDDAFSQTVKEIFGGNADKKNLVDPFVEVSFAGKKVCTNIIEKNANPE
Sbjct: 361  LLKIYRAEDIPQMDDAFSQTVKEIFGGNADKKNLVDPFVEVSFAGKKVCTNIIEKNANPE 420

Query: 421  WNQVVNLQIKFPSVCEKIKLTIYDWDRLTKNDVVGTTYLHLSKIAASGGEVEVNTGETEV 480
            WNQVVNLQIKFPSVCEKIKLTIYDWDRLTKNDVVGTTYLHLSKIAASGGEVEVNTGETEV
Sbjct: 421  WNQVVNLQIKFPSVCEKIKLTIYDWDRLTKNDVVGTTYLHLSKIAASGGEVEVNTGETEV 480

Query: 481  GFVPTFGPCYLNLYGSPREYTGFPDPYDELNTGKGEGVAYRGRILVELATFLEKTPPDKK 540
            GFVPTFGPCYLNLYGSPREYTGFPDPYDELNTGKGEGVAYRGRILVELATFLEKTPPDKK
Sbjct: 481  GFVPTFGPCYLNLYGSPREYTGFPDPYDELNTGKGEGVAYRGRILVELATFLEKTPPDKK 540

Query: 541  LEPISNDDLLVVEKYQRRRKYSLSAVFHSATMLQDVGEAIQFEVSIGNYGNKFDTTCKPL 600
            LEPISNDDLLVVEKYQRRRKYSLSAVFHSATMLQDVGEAIQFEVSIGNYGNKFDTTCKPL
Sbjct: 541  LEPISNDDLLVVEKYQRRRKYSLSAVFHSATMLQDVGEAIQFEVSIGNYGNKFDTTCKPL 600

Query: 601  ASTTQYSRAVFDGNYYYYLPWAHTKPVVTLTSYWEDISHRLDAVNTLLAMAERLQTNIEA 660
            ASTTQYSRAVFDGNYYYYLPWAHTKPVVTLTSYWEDISHRLDAVNTLLAMAERLQTNIEA
Sbjct: 601  ASTTQYSRAVFDGNYYYYLPWAHTKPVVTLTSYWEDISHRLDAVNTLLAMAERLQTNIEA 660

Query: 661  LKSGIQGKIPANQLAELWLKLIDEVIEDTRYTLPLTEGKANVTVLDTQIRKLRSRSLSQI 720
            LKSGIQGKIPANQLAELWLKLIDEVIEDTRYTLPLTEGKANVTVLDTQIRKLRSRSLSQI
Sbjct: 661  LKSGIQGKIPANQLAELWLKLIDEVIEDTRYTLPLTEGKANVTVLDTQIRKLRSRSLSQI 720

Query: 721  HEAAVRMRSEATDVKSTLAEIEDWLDKLMQLTEEPQNSMPDIIIWMIRGEKRLAYARIPA 780
            HEAAVRMRSEATDVKSTLAEIEDWLDKLMQLTEEPQNSMPDIIIWMIRGEKRLAYARIPA
Sbjct: 721  HEAAVRMRSEATDVKSTLAEIEDWLDKLMQLTEEPQNSMPDIIIWMIRGEKRLAYARIPA 780

Query: 781  HQVLYSTSGENASGKYCGKTQTIFLKYPQEKNNGPKVPVELRVNIWLGLSAVEKKFNSFA 840
            HQVLYSTSGENASGKYCGKTQTIFLKYPQEKNNGPKVPVELRVNIWLGLSAVEKKFNSFA
Sbjct: 781  HQVLYSTSGENASGKYCGKTQTIFLKYPQEKNNGPKVPVELRVNIWLGLSAVEKKFNSFA 840

Query: 841  EGTFTVFAEMYENQALMFGKWGTSGLVGRHKFSDVTGKIKLKREFFLPPKGWEWEGEWIV 900
            EGTFTVFAEMYENQALMFGKWGTSGLVGRHKFSDVTGKIKLKREFFLPPKGWEWEGEWIV
Sbjct: 841  EGTFTVFAEMYENQALMFGKWGTSGLVGRHKFSDVTGKIKLKREFFLPPKGWEWEGEWIV 900

Query: 901  DPERSLLTEADAGHTEFTDEVYQNESRYPGGDWKPAEDTYTDANGDKAASPSELTCPPGW 960
            DPERSLLTEADAGHTEFTDEVYQNESRYPGGDWKPAEDTYTDANGDKAASPSELTCPPGW
Sbjct: 901  DPERSLLTEADAGHTEFTDEVYQNESRYPGGDWKPAEDTYTDANGDKAASPSELTCPPGW 960

Query: 961  EWEDDAWSYDINRAVDEKGWEYGITIPPDHKPKSWVAAEKMYHTHRRRRLVRKRKKDLTQ 1020
            EWEDDAWSYDINRAVDEKGWEYGITIPPDHKPKSWVAAEKMYHTHRRRRLVRKRKKDLTQ
Sbjct: 961  EWEDDAWSYDINRAVDEKGWEYGITIPPDHKPKSWVAAEKMYHTHRRRRLVRKRKKDLTQ 1020

Query: 1021 TASSTARAMEELQDQEGWEYASLIGWKFHWKQRSSDTFRRRRWRRKMAPSETHGAAAIFK 1080
            TASSTARAMEELQDQEGWEYASLIGWKFHWKQRSSDTFRRRRWRRKMAPSETHGAAAIFK
Sbjct: 1021 TASSTARAMEELQDQEGWEYASLIGWKFHWKQRSSDTFRRRRWRRKMAPSETHGAAAIFK 1080

Query: 1081 LEGALGADTTEDGDEKSLEKQKHSATTVFGANTPIVSCNFDRVYIYHLRCYVYQARNLLA 1140
            LEGALGADTTEDGDEKSLEKQKHSATTVFGANTPIVSCNFDRVYIYHLRCYVYQARNLLA
Sbjct: 1081 LEGALGADTTEDGDEKSLEKQKHSATTVFGANTPIVSCNFDRVYIYHLRCYVYQARNLLA 1140

Query: 1141 LDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTWDQTIIFDEVEIYGEPQTVLQNPPKVIM 1200
            LDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTWDQTIIFDEVEIYGEPQTVLQNPPKVIM
Sbjct: 1141 LDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTWDQTIIFDEVEIYGEPQTVLQNPPKVIM 1200

Query: 1201 ELFDNDQVGKDEFLGRSIFSPVVKLNSEMDITPKLLWHPVMNGDKACGDVLVTAELILRG 1260
            ELFDNDQVGKDEFLGRSIFSPVVKLNSEMDITPKLLWHPVMNGDKACGDVLVTAELILRG
Sbjct: 1201 ELFDNDQVGKDEFLGRSIFSPVVKLNSEMDITPKLLWHPVMNGDKACGDVLVTAELILRG 1260

Query: 1261 KDGSNLPILPPQRAPNLYMVPQGIRPVVQLTAIEILAWGLRNMKNFQMASITSPSLVVEC 1320
            KDGSNLPILPPQRAPNLYMVPQGIRPVVQLTAIEILAWGLRNMKNFQMASITSPSLVVEC
Sbjct: 1261 KDGSNLPILPPQRAPNLYMVPQGIRPVVQLTAIEILAWGLRNMKNFQMASITSPSLVVEC 1320

Query: 1321 GGERVESVVIKNLKKTPNFPSSVLFMKVFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCT 1380
            GGERVESVVIKNLKKTPNFPSSVLFMKVFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCT
Sbjct: 1321 GGERVESVVIKNLKKTPNFPSSVLFMKVFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCT 1380

Query: 1381 IERLDRFRCDPYAGKEDIVPQLKASLLSAPPCRDIVIEMEDTKPLLASKLTEKEEEIVDW 1440
            IERLDRFRCDPYAGKEDIVPQLKASLLSAPPCRDIVIEMEDTKPLLASKLTEKEEEIVDW
Sbjct: 1381 IERLDRFRCDPYAGKEDIVPQLKASLLSAPPCRDIVIEMEDTKPLLASKLTEKEEEIVDW 1440

Query: 1441 WSKFYASSGEHEKCGQYIQKGYSKLKIYNCELENVAEFEGLTDFSDTFKLYRGKSDENED 1500
            WSKFYASSGEHEKCGQYIQKGYSKLKIYNCELENVAEFEGLTDFSDTFKLYRGKSDENED
Sbjct: 1441 WSKFYASSGEHEKCGQYIQKGYSKLKIYNCELENVAEFEGLTDFSDTFKLYRGKSDENED 1500

Query: 1501 PSVVGEFKGSFRIYPLPDDPSVPAPPRQFRELPDSVPQECTVRIYIVRGLELQPQDNNGL 1560
            PSVVGEFKGSFRIYPLPDDPSVPAPPRQFRELPDSVPQECTVRIYIVRGLELQPQDNNGL
Sbjct: 1501 PSVVGEFKGSFRIYPLPDDPSVPAPPRQFRELPDSVPQECTVRIYIVRGLELQPQDNNGL 1560

Query: 1561 CDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLPQEKDLKISVYDYDTFTRDEK 1620
            CDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLPQEKDLKISVYDYDTFTRDEK
Sbjct: 1561 CDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLPQEKDLKISVYDYDTFTRDEK 1620

Query: 1621 VGETIIDLENRFLSRFGSHCGIPEEYCVSGVNTWRDQLRPTQLLQNVARFKGFPQPILSE 1680
            VGETIIDLENRFLSRFGSHCGIPEEYCVSGVNTWRDQLRPTQLLQNVARFKGFPQPILSE
Sbjct: 1621 VGETIIDLENRFLSRFGSHCGIPEEYCVSGVNTWRDQLRPTQLLQNVARFKGFPQPILSE 1680

Query: 1681 DGSRIRYGGRDYSLDEFEANKILHQHLGAPEERLALHILRTQGLVPEHVETRTLHSTFQP 1740
            DGSRIRYGGRDYSLDEFEANKILHQHLGAPEERLALHILRTQGLVPEHVETRTLHSTFQP
Sbjct: 1681 DGSRIRYGGRDYSLDEFEANKILHQHLGAPEERLALHILRTQGLVPEHVETRTLHSTFQP 1740

Query: 1741 NISQGKLQMWVDVFPKSLGPPGPPFNITPRKAKKYYLRVIIWNTKDVILDEKSITGEEMS 1800
            NISQGKLQMWVDVFPKSLGPPGPPFNITPRKAKKYYLRVIIWNTKDVILDEKSITGEEMS
Sbjct: 1741 NISQGKLQMWVDVFPKSLGPPGPPFNITPRKAKKYYLRVIIWNTKDVILDEKSITGEEMS 1800

Query: 1801 DIYVKGWIPGNEENKQKTDVHYRSLDGEGNFNWRFVFPFDYLPAEQLCIVAKKEHFWSID 1860
            DIYVKGWIPGNEENKQKTDVHYRSLDGEGNFNWRFVFPFDYLPAEQLCIVAKKEHFWSID
Sbjct: 1801 DIYVKGWIPGNEENKQKTDVHYRSLDGEGNFNWRFVFPFDYLPAEQLCIVAKKEHFWSID 1860

Query: 1861 QTEFRIPPRLIIQIWDNDKFSLDDYLGFLELDLRHTIIPAKSPEKCRLDMIPDLKAMNPL 1920
            QTEFRIPPRLIIQIWDNDKFSLDDYLGFLELDLRHTIIPAKSPEKCRLDMIPDLKAMNPL
Sbjct: 1861 QTEFRIPPRLIIQIWDNDKFSLDDYLGFLELDLRHTIIPAKSPEKCRLDMIPDLKAMNPL 1920

Query: 1921 KAKTASLFEQKSMKGWWPCYAEKDGARVMAGKVEMTLEILNEKEADERPAGKGRDEPNMN 1980
            KAKTASLFEQKSMKGWWPCYAEKDGARVMAGKVEMTLEILNEKEADERPAGKGRDEPNMN
Sbjct: 1921 KAKTASLFEQKSMKGWWPCYAEKDGARVMAGKVEMTLEILNEKEADERPAGKGRDEPNMN 1980

Query: 1981 PKLDLPNRPETSFLWFTNPCKTMKFIVWRRFKWVIIGLLFLLILLLFVAVLLYSLPNYLS 2040
            PKLDLPNRPETSFLWFTNPCKTMKFIVWRRFKWVIIGLLFLLILLLFVAVLLYSLPNYLS
Sbjct: 1981 PKLDLPNRPETSFLWFTNPCKTMKFIVWRRFKWVIIGLLFLLILLLFVAVLLYSLPNYLS 2040

Query: 2041 MKIVKPNV 2048
            MKIVKPNV
Sbjct: 2041 MKIVKPNV 2048


>gi|7305053 myoferlin isoform a [Homo sapiens]
          Length = 2061

 Score = 4189 bits (10865), Expect = 0.0
 Identities = 2048/2061 (99%), Positives = 2048/2061 (99%), Gaps = 13/2061 (0%)

Query: 1    MLRVIVESASNIPKTKFGKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLD 60
            MLRVIVESASNIPKTKFGKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLD
Sbjct: 1    MLRVIVESASNIPKTKFGKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLD 60

Query: 61   FSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKGQDTGATIDL 120
            FSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKGQDTGATIDL
Sbjct: 61   FSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKGQDTGATIDL 120

Query: 121  VIGYDPPSAPHPNDLSGPSVPGMGGDGEEDEGDEDRLDNAVRGPGPKGPVGTVSEAQLAR 180
            VIGYDPPSAPHPNDLSGPSVPGMGGDGEEDEGDEDRLDNAVRGPGPKGPVGTVSEAQLAR
Sbjct: 121  VIGYDPPSAPHPNDLSGPSVPGMGGDGEEDEGDEDRLDNAVRGPGPKGPVGTVSEAQLAR 180

Query: 181  RLTKVKNSRRMLSNKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNNPF 240
            RLTKVKNSRRMLSNKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNNPF
Sbjct: 181  RLTKVKNSRRMLSNKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNNPF 240

Query: 241  FDELFFYNVNMTPSELMDEIISIRVYNSHSLRADCLMGEFKIDVGFVYDEPGHAVMRKWL 300
            FDELFFYNVNMTPSELMDEIISIRVYNSHSLRADCLMGEFKIDVGFVYDEPGHAVMRKWL
Sbjct: 241  FDELFFYNVNMTPSELMDEIISIRVYNSHSLRADCLMGEFKIDVGFVYDEPGHAVMRKWL 300

Query: 301  LLNDPEDTSSGSKGYMKVSMFVLGTGDEPPPERRDRDNDSDDVESNLLLPAGIALRWVTF 360
            LLNDPEDTSSGSKGYMKVSMFVLGTGDEPPPERRDRDNDSDDVESNLLLPAGIALRWVTF
Sbjct: 301  LLNDPEDTSSGSKGYMKVSMFVLGTGDEPPPERRDRDNDSDDVESNLLLPAGIALRWVTF 360

Query: 361  LLKIYRAEDIPQMDDAFSQTVKEIFGGNADKKNLVDPFVEVSFAGKKVCTNIIEKNANPE 420
            LLKIYRAEDIPQMDDAFSQTVKEIFGGNADKKNLVDPFVEVSFAGKKVCTNIIEKNANPE
Sbjct: 361  LLKIYRAEDIPQMDDAFSQTVKEIFGGNADKKNLVDPFVEVSFAGKKVCTNIIEKNANPE 420

Query: 421  WNQVVNLQIKFPSVCEKIKLTIYDWDRLTKNDVVGTTYLHLSKIAASGGEVE-------- 472
            WNQVVNLQIKFPSVCEKIKLTIYDWDRLTKNDVVGTTYLHLSKIAASGGEVE        
Sbjct: 421  WNQVVNLQIKFPSVCEKIKLTIYDWDRLTKNDVVGTTYLHLSKIAASGGEVEDFSSSGTG 480

Query: 473  -----VNTGETEVGFVPTFGPCYLNLYGSPREYTGFPDPYDELNTGKGEGVAYRGRILVE 527
                 VNTGETEVGFVPTFGPCYLNLYGSPREYTGFPDPYDELNTGKGEGVAYRGRILVE
Sbjct: 481  AASYTVNTGETEVGFVPTFGPCYLNLYGSPREYTGFPDPYDELNTGKGEGVAYRGRILVE 540

Query: 528  LATFLEKTPPDKKLEPISNDDLLVVEKYQRRRKYSLSAVFHSATMLQDVGEAIQFEVSIG 587
            LATFLEKTPPDKKLEPISNDDLLVVEKYQRRRKYSLSAVFHSATMLQDVGEAIQFEVSIG
Sbjct: 541  LATFLEKTPPDKKLEPISNDDLLVVEKYQRRRKYSLSAVFHSATMLQDVGEAIQFEVSIG 600

Query: 588  NYGNKFDTTCKPLASTTQYSRAVFDGNYYYYLPWAHTKPVVTLTSYWEDISHRLDAVNTL 647
            NYGNKFDTTCKPLASTTQYSRAVFDGNYYYYLPWAHTKPVVTLTSYWEDISHRLDAVNTL
Sbjct: 601  NYGNKFDTTCKPLASTTQYSRAVFDGNYYYYLPWAHTKPVVTLTSYWEDISHRLDAVNTL 660

Query: 648  LAMAERLQTNIEALKSGIQGKIPANQLAELWLKLIDEVIEDTRYTLPLTEGKANVTVLDT 707
            LAMAERLQTNIEALKSGIQGKIPANQLAELWLKLIDEVIEDTRYTLPLTEGKANVTVLDT
Sbjct: 661  LAMAERLQTNIEALKSGIQGKIPANQLAELWLKLIDEVIEDTRYTLPLTEGKANVTVLDT 720

Query: 708  QIRKLRSRSLSQIHEAAVRMRSEATDVKSTLAEIEDWLDKLMQLTEEPQNSMPDIIIWMI 767
            QIRKLRSRSLSQIHEAAVRMRSEATDVKSTLAEIEDWLDKLMQLTEEPQNSMPDIIIWMI
Sbjct: 721  QIRKLRSRSLSQIHEAAVRMRSEATDVKSTLAEIEDWLDKLMQLTEEPQNSMPDIIIWMI 780

Query: 768  RGEKRLAYARIPAHQVLYSTSGENASGKYCGKTQTIFLKYPQEKNNGPKVPVELRVNIWL 827
            RGEKRLAYARIPAHQVLYSTSGENASGKYCGKTQTIFLKYPQEKNNGPKVPVELRVNIWL
Sbjct: 781  RGEKRLAYARIPAHQVLYSTSGENASGKYCGKTQTIFLKYPQEKNNGPKVPVELRVNIWL 840

Query: 828  GLSAVEKKFNSFAEGTFTVFAEMYENQALMFGKWGTSGLVGRHKFSDVTGKIKLKREFFL 887
            GLSAVEKKFNSFAEGTFTVFAEMYENQALMFGKWGTSGLVGRHKFSDVTGKIKLKREFFL
Sbjct: 841  GLSAVEKKFNSFAEGTFTVFAEMYENQALMFGKWGTSGLVGRHKFSDVTGKIKLKREFFL 900

Query: 888  PPKGWEWEGEWIVDPERSLLTEADAGHTEFTDEVYQNESRYPGGDWKPAEDTYTDANGDK 947
            PPKGWEWEGEWIVDPERSLLTEADAGHTEFTDEVYQNESRYPGGDWKPAEDTYTDANGDK
Sbjct: 901  PPKGWEWEGEWIVDPERSLLTEADAGHTEFTDEVYQNESRYPGGDWKPAEDTYTDANGDK 960

Query: 948  AASPSELTCPPGWEWEDDAWSYDINRAVDEKGWEYGITIPPDHKPKSWVAAEKMYHTHRR 1007
            AASPSELTCPPGWEWEDDAWSYDINRAVDEKGWEYGITIPPDHKPKSWVAAEKMYHTHRR
Sbjct: 961  AASPSELTCPPGWEWEDDAWSYDINRAVDEKGWEYGITIPPDHKPKSWVAAEKMYHTHRR 1020

Query: 1008 RRLVRKRKKDLTQTASSTARAMEELQDQEGWEYASLIGWKFHWKQRSSDTFRRRRWRRKM 1067
            RRLVRKRKKDLTQTASSTARAMEELQDQEGWEYASLIGWKFHWKQRSSDTFRRRRWRRKM
Sbjct: 1021 RRLVRKRKKDLTQTASSTARAMEELQDQEGWEYASLIGWKFHWKQRSSDTFRRRRWRRKM 1080

Query: 1068 APSETHGAAAIFKLEGALGADTTEDGDEKSLEKQKHSATTVFGANTPIVSCNFDRVYIYH 1127
            APSETHGAAAIFKLEGALGADTTEDGDEKSLEKQKHSATTVFGANTPIVSCNFDRVYIYH
Sbjct: 1081 APSETHGAAAIFKLEGALGADTTEDGDEKSLEKQKHSATTVFGANTPIVSCNFDRVYIYH 1140

Query: 1128 LRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTWDQTIIFDEVEIYGE 1187
            LRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTWDQTIIFDEVEIYGE
Sbjct: 1141 LRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTWDQTIIFDEVEIYGE 1200

Query: 1188 PQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVVKLNSEMDITPKLLWHPVMNGDKAC 1247
            PQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVVKLNSEMDITPKLLWHPVMNGDKAC
Sbjct: 1201 PQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVVKLNSEMDITPKLLWHPVMNGDKAC 1260

Query: 1248 GDVLVTAELILRGKDGSNLPILPPQRAPNLYMVPQGIRPVVQLTAIEILAWGLRNMKNFQ 1307
            GDVLVTAELILRGKDGSNLPILPPQRAPNLYMVPQGIRPVVQLTAIEILAWGLRNMKNFQ
Sbjct: 1261 GDVLVTAELILRGKDGSNLPILPPQRAPNLYMVPQGIRPVVQLTAIEILAWGLRNMKNFQ 1320

Query: 1308 MASITSPSLVVECGGERVESVVIKNLKKTPNFPSSVLFMKVFLPKEELYMPPLVIKVIDH 1367
            MASITSPSLVVECGGERVESVVIKNLKKTPNFPSSVLFMKVFLPKEELYMPPLVIKVIDH
Sbjct: 1321 MASITSPSLVVECGGERVESVVIKNLKKTPNFPSSVLFMKVFLPKEELYMPPLVIKVIDH 1380

Query: 1368 RQFGRKPVVGQCTIERLDRFRCDPYAGKEDIVPQLKASLLSAPPCRDIVIEMEDTKPLLA 1427
            RQFGRKPVVGQCTIERLDRFRCDPYAGKEDIVPQLKASLLSAPPCRDIVIEMEDTKPLLA
Sbjct: 1381 RQFGRKPVVGQCTIERLDRFRCDPYAGKEDIVPQLKASLLSAPPCRDIVIEMEDTKPLLA 1440

Query: 1428 SKLTEKEEEIVDWWSKFYASSGEHEKCGQYIQKGYSKLKIYNCELENVAEFEGLTDFSDT 1487
            SKLTEKEEEIVDWWSKFYASSGEHEKCGQYIQKGYSKLKIYNCELENVAEFEGLTDFSDT
Sbjct: 1441 SKLTEKEEEIVDWWSKFYASSGEHEKCGQYIQKGYSKLKIYNCELENVAEFEGLTDFSDT 1500

Query: 1488 FKLYRGKSDENEDPSVVGEFKGSFRIYPLPDDPSVPAPPRQFRELPDSVPQECTVRIYIV 1547
            FKLYRGKSDENEDPSVVGEFKGSFRIYPLPDDPSVPAPPRQFRELPDSVPQECTVRIYIV
Sbjct: 1501 FKLYRGKSDENEDPSVVGEFKGSFRIYPLPDDPSVPAPPRQFRELPDSVPQECTVRIYIV 1560

Query: 1548 RGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLPQEKDLKI 1607
            RGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLPQEKDLKI
Sbjct: 1561 RGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLPQEKDLKI 1620

Query: 1608 SVYDYDTFTRDEKVGETIIDLENRFLSRFGSHCGIPEEYCVSGVNTWRDQLRPTQLLQNV 1667
            SVYDYDTFTRDEKVGETIIDLENRFLSRFGSHCGIPEEYCVSGVNTWRDQLRPTQLLQNV
Sbjct: 1621 SVYDYDTFTRDEKVGETIIDLENRFLSRFGSHCGIPEEYCVSGVNTWRDQLRPTQLLQNV 1680

Query: 1668 ARFKGFPQPILSEDGSRIRYGGRDYSLDEFEANKILHQHLGAPEERLALHILRTQGLVPE 1727
            ARFKGFPQPILSEDGSRIRYGGRDYSLDEFEANKILHQHLGAPEERLALHILRTQGLVPE
Sbjct: 1681 ARFKGFPQPILSEDGSRIRYGGRDYSLDEFEANKILHQHLGAPEERLALHILRTQGLVPE 1740

Query: 1728 HVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGPPFNITPRKAKKYYLRVIIWNTKDV 1787
            HVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGPPFNITPRKAKKYYLRVIIWNTKDV
Sbjct: 1741 HVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGPPFNITPRKAKKYYLRVIIWNTKDV 1800

Query: 1788 ILDEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYRSLDGEGNFNWRFVFPFDYLPAEQL 1847
            ILDEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYRSLDGEGNFNWRFVFPFDYLPAEQL
Sbjct: 1801 ILDEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYRSLDGEGNFNWRFVFPFDYLPAEQL 1860

Query: 1848 CIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSLDDYLGFLELDLRHTIIPAKSPEKCR 1907
            CIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSLDDYLGFLELDLRHTIIPAKSPEKCR
Sbjct: 1861 CIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSLDDYLGFLELDLRHTIIPAKSPEKCR 1920

Query: 1908 LDMIPDLKAMNPLKAKTASLFEQKSMKGWWPCYAEKDGARVMAGKVEMTLEILNEKEADE 1967
            LDMIPDLKAMNPLKAKTASLFEQKSMKGWWPCYAEKDGARVMAGKVEMTLEILNEKEADE
Sbjct: 1921 LDMIPDLKAMNPLKAKTASLFEQKSMKGWWPCYAEKDGARVMAGKVEMTLEILNEKEADE 1980

Query: 1968 RPAGKGRDEPNMNPKLDLPNRPETSFLWFTNPCKTMKFIVWRRFKWVIIGLLFLLILLLF 2027
            RPAGKGRDEPNMNPKLDLPNRPETSFLWFTNPCKTMKFIVWRRFKWVIIGLLFLLILLLF
Sbjct: 1981 RPAGKGRDEPNMNPKLDLPNRPETSFLWFTNPCKTMKFIVWRRFKWVIIGLLFLLILLLF 2040

Query: 2028 VAVLLYSLPNYLSMKIVKPNV 2048
            VAVLLYSLPNYLSMKIVKPNV
Sbjct: 2041 VAVLLYSLPNYLSMKIVKPNV 2061


>gi|195976777 dysferlin isoform 3 [Homo sapiens]
          Length = 2067

 Score = 2388 bits (6189), Expect = 0.0
 Identities = 1180/2096 (56%), Positives = 1515/2096 (72%), Gaps = 81/2096 (3%)

Query: 1    MLRVIVESASNIPKTKFGK-PDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPL 59
            ML  ++  ASN+P  K  +  DP+ S+ F+  KK+TK + N +NPVWNE  E+DL+GIPL
Sbjct: 1    MLCCLLVRASNLPSAKKDRRSDPVASLTFRGVKKRTKVIKNSVNPVWNEGFEWDLKGIPL 60

Query: 60   DFSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKGQDTGATID 119
            D  S L ++VKD ET+G+N+ +G A V L+++    S S  +    LL+ K Q TGA++ 
Sbjct: 61   DQGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNA-PLLDTKKQPTGASLV 119

Query: 120  LVIGYDP-----PSAPHPNDLS-GPSVPGMG----GDGEEDEGDEDRLDNAVR------- 162
            L + Y P     P  P P  L   P++P +       GEED  D+    +          
Sbjct: 120  LQVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVADTGGEEDTEDQGLTGDEAEPFLDQSG 179

Query: 163  GPGP-----KGPVGTVSEAQLARRLTKVKNSRRMLSNKPQDFQIRVRVIEGRQLSGNNIR 217
            GPG      K P          +R      SR++LS+KPQDFQIRV+VIEGRQL G NI+
Sbjct: 180  GPGAPTTPRKLPSRPPPHYPGIKRKRSAPTSRKLLSDKPQDFQIRVQVIEGRQLPGVNIK 239

Query: 218  PVVKVHVCGQTHRTRIKRGNNPFFDELFFYNVNMTPSELMDEIISIRVYNSHSLRADCLM 277
            PVVKV   GQT RTRI +GN+P F+E  F+N+  +P EL DE I I V +S SLR D L+
Sbjct: 240  PVVKVTAAGQTKRTRIHKGNSPLFNETLFFNLFDSPGELFDEPIFITVVDSRSLRTDALL 299

Query: 278  GEFKIDVGFVYDEPGHAVMRKWLLLNDPEDTSSGSKGYMKVSMFVLGTGDEPPPERRDRD 337
            GEF++DVG +Y EP HA +RKWLLL+DP+D S+G++GY+K S+ VLG GDE P ER+D  
Sbjct: 300  GEFRMDVGTIYREPRHAYLRKWLLLSDPDDFSAGARGYLKTSLCVLGPGDEAPLERKDPS 359

Query: 338  NDSDDVESNLLLPAGIALRWVTFLLKIYRAEDIPQMDDAFSQTVKEIFGGNADKKNLVDP 397
             D +D+ESNLL P G+ALR   F LK++RAED+PQMDDA    VK+IFG  ++KKNLVDP
Sbjct: 360  EDKEDIESNLLRPTGVALRGAHFCLKVFRAEDLPQMDDAVMDNVKQIFGFESNKKNLVDP 419

Query: 398  FVEVSFAGKKVCTNIIEKNANPEWNQVVNLQIKFPSVCEKIKLTIYDWDRLTKNDVVGTT 457
            FVEVSFAGK +C+ I+EK ANP+WNQ + L   FPS+CEK+++ I DWDRLT ND+V TT
Sbjct: 420  FVEVSFAGKMLCSKILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDIVATT 479

Query: 458  YLHLSKIAASGGEVEVNTGETEVGFVPTFGPCYLNLYGSPREYTGFPDPYDELNTGKGEG 517
            YL +SKI+A GGE+EV   +  +GF+PTFGPCY+NLYGSPRE+TGFPDPY ELNTGKGEG
Sbjct: 480  YLSMSKISAPGGEIEV---DDYLGFLPTFGPCYINLYGSPREFTGFPDPYTELNTGKGEG 536

Query: 518  VAYRGRILVELATFLEKTPPDKKLEPISNDDLLVVEKYQRRRKYSLSAVFHSATMLQDVG 577
            VAYRGR+L+ L T L +   ++K+E +  DD+L VEKY RRRKYSL A F+SATMLQDV 
Sbjct: 537  VAYRGRLLLSLETKLVE-HSEQKVEDLPADDILRVEKYLRRRKYSLFAAFYSATMLQDVD 595

Query: 578  EAIQFEVSIGNYGNKFDTTCKPLASTTQYSRAVFDGNYYYYLPWAHTKPVVTLTSYWEDI 637
            +AIQFEVSIGNYGNKFD TC PLASTTQYSRAVFDG +YYYLPW + KPVV L+SYWEDI
Sbjct: 596  DAIQFEVSIGNYGNKFDMTCLPLASTTQYSRAVFDGCHYYYLPWGNVKPVVVLSSYWEDI 655

Query: 638  SHRLDAVNTLLAMAERLQTNIEALKSGIQGKIPANQLAELWLKLIDEVIEDTRYTLPLTE 697
            SHR++  N LL +A+RL+  +E +   ++ +     +  L  +L DE+I      L    
Sbjct: 656  SHRIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQPLGDIH 715

Query: 698  GKANVTVLDTQIRKLRSRSLSQIHEAAVRMRSEATDVKSTLAEIEDWLDKLMQLTEEPQN 757
               + T LD  + +LR+  LSQI EAA+ ++   +++ + L + EDWL +L  L EEPQN
Sbjct: 716  ETPSATHLDQYLYQLRTHHLSQITEAALALKLGHSELPAALEQAEDWLLRLRALAEEPQN 775

Query: 758  SMPDIIIWMIRGEKRLAYARIPAHQVLYSTSGENASGKYCGKTQTIFLKYPQEKNNGPKV 817
            S+PDI+IWM++G+KR+AY R+PAHQVL+S  G N  GK CGK QTIFLKYP EK  G ++
Sbjct: 776  SLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKYPMEKVPGARM 835

Query: 818  PVELRVNIWLGLSAVEKKFNSFAEGTFTVFAEMYENQA--LMFGKWGTSGLVGRHKFSDV 875
            PV++RV +W GLS  EK+FN FAEG  +VFAE YEN+    + G WGT+GL    KFSDV
Sbjct: 836  PVQIRVKLWFGLSVDEKEFNQFAEGKLSVFAETYENETKLALVGNWGTTGLT-YPKFSDV 894

Query: 876  TGKIKLKREFFLPPKGWEWEGEWIVDPERSLLTEADAGHTEFTDEVYQNESRYPGGDWKP 935
            TGKIKL ++ F P  GW W G+W V PE++LL + DAGH  F +EV++N++R PGG W  
Sbjct: 895  TGKIKLPKDSFRPSAGWTWAGDWFVCPEKTLLHDMDAGHLSFVEEVFENQTRLPGGQWIY 954

Query: 936  AEDTYTDANGDKAASPSELTCPPGWEWEDDAWSYDINRAVDEKGWEYGITIPPDHKPKSW 995
              D YTD NG+K     ++ CP GW+WED+ WS D+NRAVDE+GWEY ITIPP+ KPK W
Sbjct: 955  MSDNYTDVNGEKVLPKDDIECPLGWKWEDEEWSTDLNRAVDEQGWEYSITIPPERKPKHW 1014

Query: 996  VAAEKMYHTHRRRRLVRKRKKDLTQTASSTARAMEELQDQEGWEYASLIGWKFHWKQRSS 1055
            V AEKMY+THRRRR VR R++DL+Q  +       E +  EGWEYASL GWKFH + R +
Sbjct: 1015 VPAEKMYYTHRRRRWVRLRRRDLSQMEALKRHRQAEAEG-EGWEYASLFGWKFHLEYRKT 1073

Query: 1056 DTFRRRRWRRKMAPSETHGAAAIFKLEGALGADTTEDGDEKSLEKQKHSATTVFGANTPI 1115
            D FRRRRWRR+M P E  G AA+F LEGALG       D+KS E     +T  FG N P 
Sbjct: 1074 DAFRRRRWRRRMEPLEKTGPAAVFALEGALGGVM----DDKS-EDSMSVSTLSFGVNRPT 1128

Query: 1116 VSCNFDRVYIYHLRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTWDQ 1175
            +SC FD    YHLRCY+YQAR+L A+DKDSFSDPYA + FLH+S+ T ++ +TLNPTWDQ
Sbjct: 1129 ISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTWDQ 1188

Query: 1176 TIIFDEVEIYGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVVKLNSEMDITPKL 1235
            T+IF E+EI+GEP TV + PP +++EL+D+D  G DEF+GR I  P       ++  P+L
Sbjct: 1189 TLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQP------SLERMPRL 1242

Query: 1236 LWHPVMNGDKACGDVLVTAELILRGK---------------------DGSNLPILPPQRA 1274
             W P+  G +  G++L + ELI R K                     + ++LP  PPQR 
Sbjct: 1243 AWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPYPPPQRE 1302

Query: 1275 PNLYMVPQGIRPVVQLTAIEILAWGLRNMKNFQMASITSPSLVVECGGERVESVVIKNLK 1334
             N+YMVPQ I+P +Q TAIEILAWGLRNMK++Q+A+I+SPSLVVECGG+ V+S VI+NL+
Sbjct: 1303 ANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTVQSCVIRNLR 1362

Query: 1335 KTPNFPSSVLFMKVFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTIERLDRFRCDPYAG 1394
            K PNF    LFM+V LP+EELY PP+ +KVID+RQFGR+PVVGQCTI  L+ F CDPY+ 
Sbjct: 1363 KNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLESFLCDPYSA 1422

Query: 1395 KEDIVPQ---LKASLLSAPPCRDIVIEMEDTKPLLASKLTEKEEEIVDWWSKFYASSGEH 1451
             E   PQ      SLLS  P  D++I+++D +PL+      +EEE +DWWSKF+AS GE 
Sbjct: 1423 -ESPSPQGGPDDVSLLS--PGEDVLIDIDDKEPLIPI----QEEEFIDWWSKFFASIGER 1475

Query: 1452 EKCGQYIQKGYSKLKIYNCELENVAEFEGLTDFSDTFKLYRGKS-DENEDPSVVGEFKGS 1510
            EKCG Y++K +  LK+Y+ +LENV  FEGL+DF +TFKLYRGK+ +E EDPSV+GEFKG 
Sbjct: 1476 EKCGSYLEKDFDTLKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEETEDPSVIGEFKGL 1535

Query: 1511 FRIYPLPDDPSVPAPPRQFRELPDSVPQECTVRIYIVRGLELQPQDNNGLCDPYIKITLG 1570
            F+IYPLP+DP++P PPRQF +L    PQEC VRIYIVR   LQP+D NG CDPYIKI++G
Sbjct: 1536 FKIYPLPEDPAIPMPPRQFHQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIG 1595

Query: 1571 KKVIEDRDHYIPNTLNPVFGRMYELSCYLPQEKDLKISVYDYDTFTRDEKVGETIIDLEN 1630
            KK + D+D+YIP TL PVFG+M+EL+C LP EKDLKI++YDYD  ++DEK+GET++DLEN
Sbjct: 1596 KKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLEN 1655

Query: 1631 RFLSRFGSHCGIPEEYCVSGVNTWRDQLRPTQLLQNVARFKGFPQPILSEDGSRIRYGGR 1690
            R LS+FG+ CG+P+ YCVSG N WRDQLRP+QLL    +      P+   D  R+ +  +
Sbjct: 1656 RLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTD--RVMFQDK 1713

Query: 1691 DYSLDEFEANKILHQHLGAPEERLALHILRTQGLVPEHVETRTLHSTFQPNISQGKLQMW 1750
            +YS++E EA +I + HLG  EERLALH+L+ QGLVPEHVE+R L+S  QP+I QGKLQMW
Sbjct: 1714 EYSIEEIEAGRIPNPHLGPVEERLALHVLQQQGLVPEHVESRPLYSPLQPDIEQGKLQMW 1773

Query: 1751 VDVFPKSLGPPGPPFNITPRKAKKYYLRVIIWNTKDVILDEKSITGEEMSDIYVKGWIPG 1810
            VD+FPK+LG PGPPFNITPR+A++++LR IIWNT+DVILD+ S+TGE+MSDIYVKGW+ G
Sbjct: 1774 VDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVILDDLSLTGEKMSDIYVKGWMIG 1833

Query: 1811 NEENKQKTDVHYRSLDGEGNFNWRFVFPFDYLPAEQLCIVAKKEHFWSIDQTEFRIPPRL 1870
             EE+KQKTDVHYRSL GEGNFNWRF+FPFDYLPAEQ+C +AKK+ FW +D+TE +IP R+
Sbjct: 1834 FEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTESKIPARV 1893

Query: 1871 IIQIWDNDKFSLDDYLGFLELDLRHTIIPAKSPEKCRLDMIPDLKAMNPLKAKTASLFEQ 1930
            + QIWDNDKFS DD+LG L+LDL     PAK+ +KC LD + D  A +P      SLFEQ
Sbjct: 1894 VFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDD--AFHP--EWFVSLFEQ 1949

Query: 1931 KSMKGWWPCYAEKDGARVMAGKVEMTLEILNEKEADERPAGKGRDEPNMNPKLDLPNRPE 1990
            K++KGWWPC AE+   +++AGK+EMTLEI+ E E +ERPAG+GRDEPNMNPKL+ P RP+
Sbjct: 1950 KTVKGWWPCVAEEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEDPRRPD 2009

Query: 1991 TSFLWFTNPCKTMKFIVWRRFKWVIIGLLFLLILLLFVAVLLYSLPNYLSMKIVKP 2046
            TSFLWFT+P KTMKFI+WRRF+W II  + L ILLLF+A+ +Y+ PNY +MK+VKP
Sbjct: 2010 TSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMKLVKP 2065


>gi|195976773 dysferlin isoform 5 [Homo sapiens]
          Length = 2088

 Score = 2385 bits (6181), Expect = 0.0
 Identities = 1181/2113 (55%), Positives = 1517/2113 (71%), Gaps = 94/2113 (4%)

Query: 1    MLRVIVESASNIPKTKFGK-PDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPL 59
            ML  ++  ASN+P  K  +  DP+ S+ F+  KK+TK + N +NPVWNE  E+DL+GIPL
Sbjct: 1    MLCCLLVRASNLPSAKKDRRSDPVASLTFRGVKKRTKVIKNSVNPVWNEGFEWDLKGIPL 60

Query: 60   DFSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKGQDTGATID 119
            D  S L ++VKD ET+G+N+ +G A V L+++    S S  +    LL+ K Q TGA++ 
Sbjct: 61   DQGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNA-PLLDTKKQPTGASLV 119

Query: 120  LVIGYDP-----PSAPHPNDLS-GPSVPGMG----GDGEEDEGDEDRLDNAVR------- 162
            L + Y P     P  P P  L   P++P +       GEED  D+    +          
Sbjct: 120  LQVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVADTGGEEDTEDQGLTGDEAEPFLDQSG 179

Query: 163  GPGP-----KGPVGTVSEAQLARRLTKVKNSRRMLSNKPQDFQIRVRVIEGRQLSGNNIR 217
            GPG      K P          +R      SR++LS+KPQDFQIRV+VIEGRQL G NI+
Sbjct: 180  GPGAPTTPRKLPSRPPPHYPGIKRKRSAPTSRKLLSDKPQDFQIRVQVIEGRQLPGVNIK 239

Query: 218  PVVKVHVCGQTHRTRIKRGNNPFFDELFFYNVNMTPSELMDEIISIRVYNSHSLRADCLM 277
            PVVKV   GQT RTRI +GN+P F+E  F+N+  +P EL DE I I V +S SLR D L+
Sbjct: 240  PVVKVTAAGQTKRTRIHKGNSPLFNETLFFNLFDSPGELFDEPIFITVVDSRSLRTDALL 299

Query: 278  GEFKIDVGFVYDEPGHAVMRKWLLLNDPEDTSSGSKGYMKVSMFVLGTGDEPPPERRDRD 337
            GEF++DVG +Y EP HA +RKWLLL+DP+D S+G++GY+K S+ VLG GDE P ER+D  
Sbjct: 300  GEFRMDVGTIYREPRHAYLRKWLLLSDPDDFSAGARGYLKTSLCVLGPGDEAPLERKDPS 359

Query: 338  NDSDDVESNLLLPAGIALRWVTFLLKIYRAEDIPQMDDAFSQTVKEIFGGNADKKNLVDP 397
             D +D+ESNLL P G+ALR   F LK++RAED+PQMDDA    VK+IFG  ++KKNLVDP
Sbjct: 360  EDKEDIESNLLRPTGVALRGAHFCLKVFRAEDLPQMDDAVMDNVKQIFGFESNKKNLVDP 419

Query: 398  FVEVSFAGKKVCTNIIEKNANPEWNQVVNLQIKFPSVCEKIKLTIYDWDRLTKNDVVGTT 457
            FVEVSFAGK +C+ I+EK ANP+WNQ + L   FPS+CEK+++ I DWDRLT ND+V TT
Sbjct: 420  FVEVSFAGKMLCSKILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDIVATT 479

Query: 458  YLHLSKIAASGGEVEVNTGETEVGFVPTFGPCYLNLYGSPREYTGFPDPYDELNTGKGEG 517
            YL +SKI+A GGE+EV   +  +GF+PTFGPCY+NLYGSPRE+TGFPDPY ELNTGKGEG
Sbjct: 480  YLSMSKISAPGGEIEV---DDYLGFLPTFGPCYINLYGSPREFTGFPDPYTELNTGKGEG 536

Query: 518  VAYRGRILVELATFLEKTPPDKKLEPISNDDLLVVEKYQRRRKYSLSAVFHSATMLQDVG 577
            VAYRGR+L+ L T L +   ++K+E +  DD+L VEKY RRRKYSL A F+SATMLQDV 
Sbjct: 537  VAYRGRLLLSLETKLVE-HSEQKVEDLPADDILRVEKYLRRRKYSLFAAFYSATMLQDVD 595

Query: 578  EAIQFEVSIGNYGNKFDTTCKPLASTTQYSRAVFDGNYYYYLPWAHTKPVVTLTSYWEDI 637
            +AIQFEVSIGNYGNKFD TC PLASTTQYSRAVFDG +YYYLPW + KPVV L+SYWEDI
Sbjct: 596  DAIQFEVSIGNYGNKFDMTCLPLASTTQYSRAVFDGCHYYYLPWGNVKPVVVLSSYWEDI 655

Query: 638  SHRLDAVNTLLAMAERLQTNIEALKSGIQGKIPANQLAELWLKLIDEVIEDTRYTLPLTE 697
            SHR++  N LL +A+RL+  +E +   ++ +     +  L  +L DE+I      L    
Sbjct: 656  SHRIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQPLGDIH 715

Query: 698  GKANVTVLDTQIRKLRSRSLSQIHEAAVRMRSEATDVKSTLAEIEDWLDKLMQLTEEPQN 757
               + T LD  + +LR+  LSQI EAA+ ++   +++ + L + EDWL +L  L EEPQN
Sbjct: 716  ETPSATHLDQYLYQLRTHHLSQITEAALALKLGHSELPAALEQAEDWLLRLRALAEEPQN 775

Query: 758  SMPDIIIWMIRGEKRLAYARIPAHQVLYSTSGENASGKYCGKTQTIFLKYPQEKNNGPKV 817
            S+PDI+IWM++G+KR+AY R+PAHQVL+S  G N  GK CGK QTIFLKYP EK  G ++
Sbjct: 776  SLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKYPMEKVPGARM 835

Query: 818  PVELRVNIWLGLSAVEKKFNSFAEGTFTVFAEMYENQA--LMFGKWGTSGLVGRHKFSDV 875
            PV++RV +W GLS  EK+FN FAEG  +VFAE YEN+    + G WGT+GL    KFSDV
Sbjct: 836  PVQIRVKLWFGLSVDEKEFNQFAEGKLSVFAETYENETKLALVGNWGTTGLT-YPKFSDV 894

Query: 876  TGKIKLKREFFLPPKGWEWEGEWIVDPERSLLTEADAGHTEFTDEVYQNESRYPGGDWKP 935
            TGKIKL ++ F P  GW W G+W V PE++LL + DAGH  F +EV++N++R PGG W  
Sbjct: 895  TGKIKLPKDSFRPSAGWTWAGDWFVCPEKTLLHDMDAGHLSFVEEVFENQTRLPGGQWIY 954

Query: 936  AEDTYTDANGDKAASPSELTCPPGWEWEDDAWSYDINRAVDEKGWEYGITIPPDHKPKSW 995
              D YTD NG+K     ++ CP GW+WED+ WS D+NRAVDE+GWEY ITIPP+ KPK W
Sbjct: 955  MSDNYTDVNGEKVLPKDDIECPLGWKWEDEEWSTDLNRAVDEQGWEYSITIPPERKPKHW 1014

Query: 996  VAAEKMYHTHRRRRLVRKRKKDLTQTASSTARAMEELQDQEGWEYASLIGWKFHWKQRSS 1055
            V AEKMY+THRRRR VR R++DL+Q  +       E +  EGWEYASL GWKFH + R +
Sbjct: 1015 VPAEKMYYTHRRRRWVRLRRRDLSQMEALKRHRQAEAEG-EGWEYASLFGWKFHLEYRKT 1073

Query: 1056 DTFRRRRWRRKMAPSETHGAAAIFKLEGALGADTTEDGDEKSLEKQKHSATTVFGANTPI 1115
            D FRRRRWRR+M P E  G AA+F LEGALG       D+KS E     +T  FG N P 
Sbjct: 1074 DAFRRRRWRRRMEPLEKTGPAAVFALEGALGGVM----DDKS-EDSMSVSTLSFGVNRPT 1128

Query: 1116 VSCNFDRVYIYHLRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTWDQ 1175
            +SC FD    YHLRCY+YQAR+L A+DKDSFSDPYA + FLH+S+ T ++ +TLNPTWDQ
Sbjct: 1129 ISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTWDQ 1188

Query: 1176 TIIFDEVEIYGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVVKLNSEMDITPKL 1235
            T+IF E+EI+GEP TV + PP +++EL+D+D  G DEF+GR I  P       ++  P+L
Sbjct: 1189 TLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQP------SLERMPRL 1242

Query: 1236 LWHPVMNGDKACGDVLVTAELILRGK---------------------DGSNLPILPPQRA 1274
             W P+  G +  G++L + ELI R K                     + ++LP  PPQR 
Sbjct: 1243 AWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPYPPPQRE 1302

Query: 1275 PNLYMVPQGIRPVVQLTAIEILAWGLRNMKNFQMASITSPSLVVECGGERVESVVIKNLK 1334
             N+YMVPQ I+P +Q TAIEILAWGLRNMK++Q+A+I+SPSLVVECGG+ V+S VI+NL+
Sbjct: 1303 ANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTVQSCVIRNLR 1362

Query: 1335 KTPNFPSSVLFMKVFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTIERLDRFRCDPYAG 1394
            K PNF    LFM+V LP+EELY PP+ +KVID+RQFGR+PVVGQCTI  L+ F CDPY+ 
Sbjct: 1363 KNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLESFLCDPYSA 1422

Query: 1395 KEDIVPQ---LKASLLSAPPCRDIVIEMEDTKPLLASKLTE-----------------KE 1434
             E   PQ      SLLS  P  D++I+++D +PL+  +L +                  E
Sbjct: 1423 -ESPSPQGGPDDVSLLS--PGEDVLIDIDDKEPLIPIQLADGLSSLAPTNTASPPSSPHE 1479

Query: 1435 EEIVDWWSKFYASSGEHEKCGQYIQKGYSKLKIYNCELENVAEFEGLTDFSDTFKLYRGK 1494
            EE +DWWSKF+AS GE EKCG Y++K +  LK+Y+ +LENV  FEGL+DF +TFKLYRGK
Sbjct: 1480 EEFIDWWSKFFASIGEREKCGSYLEKDFDTLKVYDTQLENVEAFEGLSDFCNTFKLYRGK 1539

Query: 1495 S-DENEDPSVVGEFKGSFRIYPLPDDPSVPAPPRQFRELPDSVPQECTVRIYIVRGLELQ 1553
            + +E EDPSV+GEFKG F+IYPLP+DP++P PPRQF +L    PQEC VRIYIVR   LQ
Sbjct: 1540 TQEETEDPSVIGEFKGLFKIYPLPEDPAIPMPPRQFHQLAAQGPQECLVRIYIVRAFGLQ 1599

Query: 1554 PQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLPQEKDLKISVYDYD 1613
            P+D NG CDPYIKI++GKK + D+D+YIP TL PVFG+M+EL+C LP EKDLKI++YDYD
Sbjct: 1600 PKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYD 1659

Query: 1614 TFTRDEKVGETIIDLENRFLSRFGSHCGIPEEYCVSGVNTWRDQLRPTQLLQNVARFKGF 1673
              ++DEK+GET++DLENR LS+FG+ CG+P+ YCVSG N WRDQLRP+QLL    +    
Sbjct: 1660 LLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRV 1719

Query: 1674 PQPILSEDGSRIRYGGRDYSLDEFEANKILHQHLGAPEERLALHILRTQGLVPEHVETRT 1733
              P+   D  R+ +  ++YS++E EA +I + HLG  EERLALH+L+ QGLVPEHVE+R 
Sbjct: 1720 KAPVYRTD--RVMFQDKEYSIEEIEAGRIPNPHLGPVEERLALHVLQQQGLVPEHVESRP 1777

Query: 1734 LHSTFQPNISQGKLQMWVDVFPKSLGPPGPPFNITPRKAKKYYLRVIIWNTKDVILDEKS 1793
            L+S  QP+I QGKLQMWVD+FPK+LG PGPPFNITPR+A++++LR IIWNT+DVILD+ S
Sbjct: 1778 LYSPLQPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVILDDLS 1837

Query: 1794 ITGEEMSDIYVKGWIPGNEENKQKTDVHYRSLDGEGNFNWRFVFPFDYLPAEQLCIVAKK 1853
            +TGE+MSDIYVKGW+ G EE+KQKTDVHYRSL GEGNFNWRF+FPFDYLPAEQ+C +AKK
Sbjct: 1838 LTGEKMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKK 1897

Query: 1854 EHFWSIDQTEFRIPPRLIIQIWDNDKFSLDDYLGFLELDLRHTIIPAKSPEKCRLDMIPD 1913
            + FW +D+TE +IP R++ QIWDNDKFS DD+LG L+LDL     PAK+ +KC LD + D
Sbjct: 1898 DAFWRLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDD 1957

Query: 1914 LKAMNPLKAKTASLFEQKSMKGWWPCYAEKDGARVMAGKVEMTLEILNEKEADERPAGKG 1973
              A +P      SLFEQK++KGWWPC AE+   +++AGK+EMTLEI+ E E +ERPAG+G
Sbjct: 1958 --AFHP--EWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEMTLEIVAESEHEERPAGQG 2013

Query: 1974 RDEPNMNPKLDLPNRPETSFLWFTNPCKTMKFIVWRRFKWVIIGLLFLLILLLFVAVLLY 2033
            RDEPNMNPKL+ P RP+TSFLWFT+P KTMKFI+WRRF+W II  + L ILLLF+A+ +Y
Sbjct: 2014 RDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIY 2073

Query: 2034 SLPNYLSMKIVKP 2046
            + PNY +MK+VKP
Sbjct: 2074 AFPNYAAMKLVKP 2086


>gi|195976754 dysferlin isoform 9 [Homo sapiens]
          Length = 2066

 Score = 2383 bits (6175), Expect = 0.0
 Identities = 1178/2095 (56%), Positives = 1509/2095 (72%), Gaps = 80/2095 (3%)

Query: 1    MLRVIVESASNIPKTKFGKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLD 60
            MLRV +  A N+        D   S +F   KK+TK + N +NPVWNE  E+DL+GIPLD
Sbjct: 1    MLRVFILYAENVHTPDTDISDAYCSAVFAGVKKRTKVIKNSVNPVWNEGFEWDLKGIPLD 60

Query: 61   FSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKGQDTGATIDL 120
              S L ++VKD ET+G+N+ +G A V L+++    S S  +    LL+ K Q TGA++ L
Sbjct: 61   QGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNA-PLLDTKKQPTGASLVL 119

Query: 121  VIGYDP-----PSAPHPNDLS-GPSVPGMG----GDGEEDEGDEDRLDNAVR-------G 163
             + Y P     P  P P  L   P++P +       GEED  D+    +          G
Sbjct: 120  QVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVADTGGEEDTEDQGLTGDEAEPFLDQSGG 179

Query: 164  PGP-----KGPVGTVSEAQLARRLTKVKNSRRMLSNKPQDFQIRVRVIEGRQLSGNNIRP 218
            PG      K P          +R      SR++LS+KPQDFQIRV+VIEGRQL G NI+P
Sbjct: 180  PGAPTTPRKLPSRPPPHYPGIKRKRSAPTSRKLLSDKPQDFQIRVQVIEGRQLPGVNIKP 239

Query: 219  VVKVHVCGQTHRTRIKRGNNPFFDELFFYNVNMTPSELMDEIISIRVYNSHSLRADCLMG 278
            VVKV   GQT RTRI +GN+P F+E  F+N+  +P EL DE I I V +S SLR D L+G
Sbjct: 240  VVKVTAAGQTKRTRIHKGNSPLFNETLFFNLFDSPGELFDEPIFITVVDSRSLRTDALLG 299

Query: 279  EFKIDVGFVYDEPGHAVMRKWLLLNDPEDTSSGSKGYMKVSMFVLGTGDEPPPERRDRDN 338
            EF++DVG +Y EP HA +RKWLLL+DP+D S+G++GY+K S+ VLG GDE P ER+D   
Sbjct: 300  EFRMDVGTIYREPRHAYLRKWLLLSDPDDFSAGARGYLKTSLCVLGPGDEAPLERKDPSE 359

Query: 339  DSDDVESNLLLPAGIALRWVTFLLKIYRAEDIPQMDDAFSQTVKEIFGGNADKKNLVDPF 398
            D +D+ESNLL P G+ALR   F LK++RAED+PQMDDA    VK+IFG  ++KKNLVDPF
Sbjct: 360  DKEDIESNLLRPTGVALRGAHFCLKVFRAEDLPQMDDAVMDNVKQIFGFESNKKNLVDPF 419

Query: 399  VEVSFAGKKVCTNIIEKNANPEWNQVVNLQIKFPSVCEKIKLTIYDWDRLTKNDVVGTTY 458
            VEVSFAGK +C+ I+EK ANP+WNQ + L   FPS+CEK+++ I DWDRLT ND+V TTY
Sbjct: 420  VEVSFAGKMLCSKILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDIVATTY 479

Query: 459  LHLSKIAASGGEVEVNTGETEVGFVPTFGPCYLNLYGSPREYTGFPDPYDELNTGKGEGV 518
            L +SKI+A GGE+EV   +  +GF+PTFGPCY+NLYGSPRE+TGFPDPY ELNTGKGEGV
Sbjct: 480  LSMSKISAPGGEIEV---DDYLGFLPTFGPCYINLYGSPREFTGFPDPYTELNTGKGEGV 536

Query: 519  AYRGRILVELATFLEKTPPDKKLEPISNDDLLVVEKYQRRRKYSLSAVFHSATMLQDVGE 578
            AYRGR+L+ L T L +   ++K+E +  DD+L VEKY RRRKYSL A F+SATMLQDV +
Sbjct: 537  AYRGRLLLSLETKLVE-HSEQKVEDLPADDILRVEKYLRRRKYSLFAAFYSATMLQDVDD 595

Query: 579  AIQFEVSIGNYGNKFDTTCKPLASTTQYSRAVFDGNYYYYLPWAHTKPVVTLTSYWEDIS 638
            AIQFEVSIGNYGNKFD TC PLASTTQYSRAVFDG +YYYLPW + KPVV L+SYWEDIS
Sbjct: 596  AIQFEVSIGNYGNKFDMTCLPLASTTQYSRAVFDGCHYYYLPWGNVKPVVVLSSYWEDIS 655

Query: 639  HRLDAVNTLLAMAERLQTNIEALKSGIQGKIPANQLAELWLKLIDEVIEDTRYTLPLTEG 698
            HR++  N LL +A+RL+  +E +   ++ +     +  L  +L DE+I      L     
Sbjct: 656  HRIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQPLGDIHE 715

Query: 699  KANVTVLDTQIRKLRSRSLSQIHEAAVRMRSEATDVKSTLAEIEDWLDKLMQLTEEPQNS 758
              + T LD  + +LR+  LSQI EAA+ ++   +++ + L + EDWL +L  L EEPQNS
Sbjct: 716  TPSATHLDQYLYQLRTHHLSQITEAALALKLGHSELPAALEQAEDWLLRLRALAEEPQNS 775

Query: 759  MPDIIIWMIRGEKRLAYARIPAHQVLYSTSGENASGKYCGKTQTIFLKYPQEKNNGPKVP 818
            +PDI+IWM++G+KR+AY R+PAHQVL+S  G N  GK CGK QTIFLKYP EK  G ++P
Sbjct: 776  LPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKYPMEKVPGARMP 835

Query: 819  VELRVNIWLGLSAVEKKFNSFAEGTFTVFAEMYENQA--LMFGKWGTSGLVGRHKFSDVT 876
            V++RV +W GLS  EK+FN FAEG  +VFAE YEN+    + G WGT+GL    KFSDVT
Sbjct: 836  VQIRVKLWFGLSVDEKEFNQFAEGKLSVFAETYENETKLALVGNWGTTGLT-YPKFSDVT 894

Query: 877  GKIKLKREFFLPPKGWEWEGEWIVDPERSLLTEADAGHTEFTDEVYQNESRYPGGDWKPA 936
            GKIKL ++ F P  GW W G+W V PE++LL + DAGH  F +EV++N++R PGG W   
Sbjct: 895  GKIKLPKDSFRPSAGWTWAGDWFVCPEKTLLHDMDAGHLSFVEEVFENQTRLPGGQWIYM 954

Query: 937  EDTYTDANGDKAASPSELTCPPGWEWEDDAWSYDINRAVDEKGWEYGITIPPDHKPKSWV 996
             D YTD NG+K     ++ CP GW+WED+ WS D+NRAVDE+GWEY ITIPP+ KPK WV
Sbjct: 955  SDNYTDVNGEKVLPKDDIECPLGWKWEDEEWSTDLNRAVDEQGWEYSITIPPERKPKHWV 1014

Query: 997  AAEKMYHTHRRRRLVRKRKKDLTQTASSTARAMEELQDQEGWEYASLIGWKFHWKQRSSD 1056
             AEKMY+THRRRR VR R++DL+Q  +       E +  EGWEYASL GWKFH + R +D
Sbjct: 1015 PAEKMYYTHRRRRWVRLRRRDLSQMEALKRHRQAEAEG-EGWEYASLFGWKFHLEYRKTD 1073

Query: 1057 TFRRRRWRRKMAPSETHGAAAIFKLEGALGADTTEDGDEKSLEKQKHSATTVFGANTPIV 1116
             FRRRRWRR+M P E  G AA+F LEGALG       D+KS E     +T  FG N P +
Sbjct: 1074 AFRRRRWRRRMEPLEKTGPAAVFALEGALGGVM----DDKS-EDSMSVSTLSFGVNRPTI 1128

Query: 1117 SCNFDRVYIYHLRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTWDQT 1176
            SC FD    YHLRCY+YQAR+L A+DKDSFSDPYA + FLH+S+ T ++ +TLNPTWDQT
Sbjct: 1129 SCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTWDQT 1188

Query: 1177 IIFDEVEIYGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVVKLNSEMDITPKLL 1236
            +IF E+EI+GEP TV + PP +++EL+D+D  G DEF+GR I  P       ++  P+L 
Sbjct: 1189 LIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQP------SLERMPRLA 1242

Query: 1237 WHPVMNGDKACGDVLVTAELILRGK---------------------DGSNLPILPPQRAP 1275
            W P+  G +  G++L + ELI R K                     + ++LP  PPQR  
Sbjct: 1243 WFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPYPPPQREA 1302

Query: 1276 NLYMVPQGIRPVVQLTAIEILAWGLRNMKNFQMASITSPSLVVECGGERVESVVIKNLKK 1335
            N+YMVPQ I+P +Q TAIEILAWGLRNMK++Q+A+I+SPSLVVECGG+ V+S VI+NL+K
Sbjct: 1303 NIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTVQSCVIRNLRK 1362

Query: 1336 TPNFPSSVLFMKVFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTIERLDRFRCDPYAGK 1395
             PNF    LFM+V LP+EELY PP+ +KVID+RQFGR+PVVGQCTI  L+ F CDPY+  
Sbjct: 1363 NPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLESFLCDPYSA- 1421

Query: 1396 EDIVPQ---LKASLLSAPPCRDIVIEMEDTKPLLASKLTEKEEEIVDWWSKFYASSGEHE 1452
            E   PQ      SLLS  P  D++I+++D +PL+      +EEE +DWWSKF+AS GE E
Sbjct: 1422 ESPSPQGGPDDVSLLS--PGEDVLIDIDDKEPLIPI----QEEEFIDWWSKFFASIGERE 1475

Query: 1453 KCGQYIQKGYSKLKIYNCELENVAEFEGLTDFSDTFKLYRGKS-DENEDPSVVGEFKGSF 1511
            KCG Y++K +  LK+Y+ +LENV  FEGL+DF +TFKLYRGK+ +E EDPSV+GEFKG F
Sbjct: 1476 KCGSYLEKDFDTLKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEETEDPSVIGEFKGLF 1535

Query: 1512 RIYPLPDDPSVPAPPRQFRELPDSVPQECTVRIYIVRGLELQPQDNNGLCDPYIKITLGK 1571
            +IYPLP+DP++P PPRQF +L    PQEC VRIYIVR   LQP+D NG CDPYIKI++GK
Sbjct: 1536 KIYPLPEDPAIPMPPRQFHQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGK 1595

Query: 1572 KVIEDRDHYIPNTLNPVFGRMYELSCYLPQEKDLKISVYDYDTFTRDEKVGETIIDLENR 1631
            K + D+D+YIP TL PVFG+M+EL+C LP EKDLKI++YDYD  ++DEK+GET++DLENR
Sbjct: 1596 KSVSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENR 1655

Query: 1632 FLSRFGSHCGIPEEYCVSGVNTWRDQLRPTQLLQNVARFKGFPQPILSEDGSRIRYGGRD 1691
             LS+FG+ CG+P+ YCVSG N WRDQLRP+QLL    +      P+   D  R+ +  ++
Sbjct: 1656 LLSKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTD--RVMFQDKE 1713

Query: 1692 YSLDEFEANKILHQHLGAPEERLALHILRTQGLVPEHVETRTLHSTFQPNISQGKLQMWV 1751
            YS++E EA +I + HLG  EERLALH+L+ QGLVPEHVE+R L+S  QP+I QGKLQMWV
Sbjct: 1714 YSIEEIEAGRIPNPHLGPVEERLALHVLQQQGLVPEHVESRPLYSPLQPDIEQGKLQMWV 1773

Query: 1752 DVFPKSLGPPGPPFNITPRKAKKYYLRVIIWNTKDVILDEKSITGEEMSDIYVKGWIPGN 1811
            D+FPK+LG PGPPFNITPR+A++++LR IIWNT+DVILD+ S+TGE+MSDIYVKGW+ G 
Sbjct: 1774 DLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVILDDLSLTGEKMSDIYVKGWMIGF 1833

Query: 1812 EENKQKTDVHYRSLDGEGNFNWRFVFPFDYLPAEQLCIVAKKEHFWSIDQTEFRIPPRLI 1871
            EE+KQKTDVHYRSL GEGNFNWRF+FPFDYLPAEQ+C +AKK+ FW +D+TE +IP R++
Sbjct: 1834 EEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTESKIPARVV 1893

Query: 1872 IQIWDNDKFSLDDYLGFLELDLRHTIIPAKSPEKCRLDMIPDLKAMNPLKAKTASLFEQK 1931
             QIWDNDKFS DD+LG L+LDL     PAK+ +KC LD + D  A +P      SLFEQK
Sbjct: 1894 FQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDD--AFHP--EWFVSLFEQK 1949

Query: 1932 SMKGWWPCYAEKDGARVMAGKVEMTLEILNEKEADERPAGKGRDEPNMNPKLDLPNRPET 1991
            ++KGWWPC AE+   +++AGK+EMTLEI+ E E +ERPAG+GRDEPNMNPKL+ P RP+T
Sbjct: 1950 TVKGWWPCVAEEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEDPRRPDT 2009

Query: 1992 SFLWFTNPCKTMKFIVWRRFKWVIIGLLFLLILLLFVAVLLYSLPNYLSMKIVKP 2046
            SFLWFT+P KTMKFI+WRRF+W II  + L ILLLF+A+ +Y+ PNY +MK+VKP
Sbjct: 2010 SFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMKLVKP 2064


>gi|195976821 dysferlin isoform 2 [Homo sapiens]
          Length = 2081

 Score = 2382 bits (6174), Expect = 0.0
 Identities = 1179/2107 (55%), Positives = 1514/2107 (71%), Gaps = 89/2107 (4%)

Query: 1    MLRVIVESASNIPKTKFGK-PDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPL 59
            ML  ++  ASN+P  K  +  DP+ S+ F+  KK+TK + N +NPVWNE  E+DL+GIPL
Sbjct: 1    MLCCLLVRASNLPSAKKDRRSDPVASLTFRGVKKRTKVIKNSVNPVWNEGFEWDLKGIPL 60

Query: 60   DFSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKGQDTGATID 119
            D  S L ++VKD ET+G+N+ +G A V L+++    S S  +    LL+ K Q TGA++ 
Sbjct: 61   DQGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNA-PLLDTKKQPTGASLV 119

Query: 120  LVIGYDP-----PSAPHPNDLS-GPSVPGMG----GDGEEDEGDEDRLDNAVR------- 162
            L + Y P     P  P P  L   P++P +       GEED  D+    +          
Sbjct: 120  LQVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVADTGGEEDTEDQGLTGDEAEPFLDQSG 179

Query: 163  GPGP-----KGPVGTVSEAQLARRLTKVKNSRRMLSNKPQDFQIRVRVIEGRQLSGNNIR 217
            GPG      K P          +R      SR++LS+KPQDFQIRV+VIEGRQL G NI+
Sbjct: 180  GPGAPTTPRKLPSRPPPHYPGIKRKRSAPTSRKLLSDKPQDFQIRVQVIEGRQLPGVNIK 239

Query: 218  PVVKVHVCGQTHRTRIKRGNNPFFDELFFYNVNMTPSELMDEIISIRVYNSHSLRADCLM 277
            PVVKV   GQT RTRI +GN+P F+E  F+N+  +P EL DE I I V +S SLR D L+
Sbjct: 240  PVVKVTAAGQTKRTRIHKGNSPLFNETLFFNLFDSPGELFDEPIFITVVDSRSLRTDALL 299

Query: 278  GEFKIDVGFVYDEPGHAVMRKWLLLNDPEDTSSGSKGYMKVSMFVLGTGDEPPPERRDRD 337
            GEF++DVG +Y EP HA +RKWLLL+DP+D S+G++GY+K S+ VLG GDE P ER+D  
Sbjct: 300  GEFRMDVGTIYREPRHAYLRKWLLLSDPDDFSAGARGYLKTSLCVLGPGDEAPLERKDPS 359

Query: 338  NDSDDVESNLLLPAGIALRWVTFLLKIYRAEDIPQMDDAFSQTVKEIFGGNADKKNLVDP 397
             D +D+ESNLL P G+ALR   F LK++RAED+PQMDDA    VK+IFG  ++KKNLVDP
Sbjct: 360  EDKEDIESNLLRPTGVALRGAHFCLKVFRAEDLPQMDDAVMDNVKQIFGFESNKKNLVDP 419

Query: 398  FVEVSFAGKKVCTNIIEKNANPEWNQVVNLQIKFPSVCEKIKLTIYDWDRLTKNDVVGTT 457
            FVEVSFAGK +C+ I+EK ANP+WNQ + L   FPS+CEK+++ I DWDRLT ND+V TT
Sbjct: 420  FVEVSFAGKMLCSKILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDIVATT 479

Query: 458  YLHLSKIAASGGEVEVNTG-----------ETEVGFVPTFGPCYLNLYGSPREYTGFPDP 506
            YL +SKI+A GGE+E               +  +GF+PTFGPCY+NLYGSPRE+TGFPDP
Sbjct: 480  YLSMSKISAPGGEIEEEPAGAVKPSKASDLDDYLGFLPTFGPCYINLYGSPREFTGFPDP 539

Query: 507  YDELNTGKGEGVAYRGRILVELATFLEKTPPDKKLEPISNDDLLVVEKYQRRRKYSLSAV 566
            Y ELNTGKGEGVAYRGR+L+ L T L +   ++K+E +  DD+L VEKY RRRKYSL A 
Sbjct: 540  YTELNTGKGEGVAYRGRLLLSLETKLVE-HSEQKVEDLPADDILRVEKYLRRRKYSLFAA 598

Query: 567  FHSATMLQDVGEAIQFEVSIGNYGNKFDTTCKPLASTTQYSRAVFDGNYYYYLPWAHTKP 626
            F+SATMLQDV +AIQFEVSIGNYGNKFD TC PLASTTQYSRAVFDG +YYYLPW + KP
Sbjct: 599  FYSATMLQDVDDAIQFEVSIGNYGNKFDMTCLPLASTTQYSRAVFDGCHYYYLPWGNVKP 658

Query: 627  VVTLTSYWEDISHRLDAVNTLLAMAERLQTNIEALKSGIQGKIPANQLAELWLKLIDEVI 686
            VV L+SYWEDISHR++  N LL +A+RL+  +E +   ++ +     +  L  +L DE+I
Sbjct: 659  VVVLSSYWEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQLTDELI 718

Query: 687  EDTRYTLPLTEGKANVTVLDTQIRKLRSRSLSQIHEAAVRMRSEATDVKSTLAEIEDWLD 746
                  L       + T LD  + +LR+  LSQI EAA+ ++   +++ + L + EDWL 
Sbjct: 719  AGCSQPLGDIHETPSATHLDQYLYQLRTHHLSQITEAALALKLGHSELPAALEQAEDWLL 778

Query: 747  KLMQLTEEPQNSMPDIIIWMIRGEKRLAYARIPAHQVLYSTSGENASGKYCGKTQTIFLK 806
            +L  L EEPQNS+PDI+IWM++G+KR+AY R+PAHQVL+S  G N  GK CGK QTIFLK
Sbjct: 779  RLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFLK 838

Query: 807  YPQEKNNGPKVPVELRVNIWLGLSAVEKKFNSFAEGTFTVFAEMYENQA--LMFGKWGTS 864
            YP EK  G ++PV++RV +W GLS  EK+FN FAEG  +VFAE YEN+    + G WGT+
Sbjct: 839  YPMEKVPGARMPVQIRVKLWFGLSVDEKEFNQFAEGKLSVFAETYENETKLALVGNWGTT 898

Query: 865  GLVGRHKFSDVTGKIKLKREFFLPPKGWEWEGEWIVDPERSLLTEADAGHTEFTDEVYQN 924
            GL    KFSDVTGKIKL ++ F P  GW W G+W V PE++LL + DAGH  F +EV++N
Sbjct: 899  GLT-YPKFSDVTGKIKLPKDSFRPSAGWTWAGDWFVCPEKTLLHDMDAGHLSFVEEVFEN 957

Query: 925  ESRYPGGDWKPAEDTYTDANGDKAASPSELTCPPGWEWEDDAWSYDINRAVDEKGWEYGI 984
            ++R PGG W    D YTD NG+K     ++ CP GW+WED+ WS D+NRAVDE+GWEY I
Sbjct: 958  QTRLPGGQWIYMSDNYTDVNGEKVLPKDDIECPLGWKWEDEEWSTDLNRAVDEQGWEYSI 1017

Query: 985  TIPPDHKPKSWVAAEKMYHTHRRRRLVRKRKKDLTQTASSTARAMEELQDQEGWEYASLI 1044
            TIPP+ KPK WV AEKMY+THRRRR VR R++DL+Q  +       E +  EGWEYASL 
Sbjct: 1018 TIPPERKPKHWVPAEKMYYTHRRRRWVRLRRRDLSQMEALKRHRQAEAEG-EGWEYASLF 1076

Query: 1045 GWKFHWKQRSSDTFRRRRWRRKMAPSETHGAAAIFKLEGALGADTTEDGDEKSLEKQKHS 1104
            GWKFH + R +D FRRRRWRR+M P E  G AA+F LEGALG       D+KS E     
Sbjct: 1077 GWKFHLEYRKTDAFRRRRWRRRMEPLEKTGPAAVFALEGALGGVM----DDKS-EDSMSV 1131

Query: 1105 ATTVFGANTPIVSCNFDRVYIYHLRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTEI 1164
            +T  FG N P +SC FD    YHLRCY+YQAR+L A+DKDSFSDPYA + FLH+S+ T +
Sbjct: 1132 STLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVV 1191

Query: 1165 IHSTLNPTWDQTIIFDEVEIYGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVVK 1224
            + +TLNPTWDQT+IF E+EI+GEP TV + PP +++EL+D+D  G DEF+GR I  P   
Sbjct: 1192 VKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQP--- 1248

Query: 1225 LNSEMDITPKLLWHPVMNGDKACGDVLVTAELILRGK---------------------DG 1263
                ++  P+L W P+  G +  G++L + ELI R K                     + 
Sbjct: 1249 ---SLERMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESED 1305

Query: 1264 SNLPILPPQRAPNLYMVPQGIRPVVQLTAIEILAWGLRNMKNFQMASITSPSLVVECGGE 1323
            ++LP  PPQR  N+YMVPQ I+P +Q TAIEILAWGLRNMK++Q+A+I+SPSLVVECGG+
Sbjct: 1306 TDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQ 1365

Query: 1324 RVESVVIKNLKKTPNFPSSVLFMKVFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTIER 1383
             V+S VI+NL+K PNF    LFM+V LP+EELY PP+ +KVID+RQFGR+PVVGQCTI  
Sbjct: 1366 TVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRS 1425

Query: 1384 LDRFRCDPYAGKEDIVPQ---LKASLLSAPPCRDIVIEMEDTKPLLASKLTEKEEEIVDW 1440
            L+ F CDPY+  E   PQ      SLLS  P  D++I+++D +PL+      +EEE +DW
Sbjct: 1426 LESFLCDPYSA-ESPSPQGGPDDVSLLS--PGEDVLIDIDDKEPLIPI----QEEEFIDW 1478

Query: 1441 WSKFYASSGEHEKCGQYIQKGYSKLKIYNCELENVAEFEGLTDFSDTFKLYRGKS-DENE 1499
            WSKF+AS GE EKCG Y++K +  LK+Y+ +LENV  FEGL+DF +TFKLYRGK+ +E E
Sbjct: 1479 WSKFFASIGEREKCGSYLEKDFDTLKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEETE 1538

Query: 1500 DPSVVGEFKGSFRIYPLPDDPSVPAPPRQFRELPDSVPQECTVRIYIVRGLELQPQDNNG 1559
            DPSV+GEFKG F+IYPLP+DP++P PPRQF +L    PQEC VRIYIVR   LQP+D NG
Sbjct: 1539 DPSVIGEFKGLFKIYPLPEDPAIPMPPRQFHQLAAQGPQECLVRIYIVRAFGLQPKDPNG 1598

Query: 1560 LCDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLPQEKDLKISVYDYDTFTRDE 1619
             CDPYIKI++GKK + D+D+YIP TL PVFG+M+EL+C LP EKDLKI++YDYD  ++DE
Sbjct: 1599 KCDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDE 1658

Query: 1620 KVGETIIDLENRFLSRFGSHCGIPEEYCVSGVNTWRDQLRPTQLLQNVARFKGFPQPILS 1679
            K+GET++DLENR LS+FG+ CG+P+ YCVSG N WRDQLRP+QLL    +      P+  
Sbjct: 1659 KIGETVVDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYR 1718

Query: 1680 EDGSRIRYGGRDYSLDEFEANKILHQHLGAPEERLALHILRTQGLVPEHVETRTLHSTFQ 1739
             D  R+ +  ++YS++E EA +I + HLG  EERLALH+L+ QGLVPEHVE+R L+S  Q
Sbjct: 1719 TD--RVMFQDKEYSIEEIEAGRIPNPHLGPVEERLALHVLQQQGLVPEHVESRPLYSPLQ 1776

Query: 1740 PNISQGKLQMWVDVFPKSLGPPGPPFNITPRKAKKYYLRVIIWNTKDVILDEKSITGEEM 1799
            P+I QGKLQMWVD+FPK+LG PGPPFNITPR+A++++LR IIWNT+DVILD+ S+TGE+M
Sbjct: 1777 PDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVILDDLSLTGEKM 1836

Query: 1800 SDIYVKGWIPGNEENKQKTDVHYRSLDGEGNFNWRFVFPFDYLPAEQLCIVAKKEHFWSI 1859
            SDIYVKGW+ G EE+KQKTDVHYRSL GEGNFNWRF+FPFDYLPAEQ+C +AKK+ FW +
Sbjct: 1837 SDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWRL 1896

Query: 1860 DQTEFRIPPRLIIQIWDNDKFSLDDYLGFLELDLRHTIIPAKSPEKCRLDMIPDLKAMNP 1919
            D+TE +IP R++ QIWDNDKFS DD+LG L+LDL     PAK+ +KC LD + D  A +P
Sbjct: 1897 DKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDD--AFHP 1954

Query: 1920 LKAKTASLFEQKSMKGWWPCYAEKDGARVMAGKVEMTLEILNEKEADERPAGKGRDEPNM 1979
                  SLFEQK++KGWWPC AE+   +++AGK+EMTLEI+ E E +ERPAG+GRDEPNM
Sbjct: 1955 --EWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNM 2012

Query: 1980 NPKLDLPNRPETSFLWFTNPCKTMKFIVWRRFKWVIIGLLFLLILLLFVAVLLYSLPNYL 2039
            NPKL+ P RP+TSFLWFT+P KTMKFI+WRRF+W II  + L ILLLF+A+ +Y+ PNY 
Sbjct: 2013 NPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYA 2072

Query: 2040 SMKIVKP 2046
            +MK+VKP
Sbjct: 2073 AMKLVKP 2079


>gi|195976775 dysferlin isoform 4 [Homo sapiens]
          Length = 2098

 Score = 2380 bits (6167), Expect = 0.0
 Identities = 1180/2127 (55%), Positives = 1519/2127 (71%), Gaps = 112/2127 (5%)

Query: 1    MLRVIVESASNIPKTKFGK-PDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPL 59
            ML  ++  ASN+P  K  +  DP+ S+ F+  KK+TK + N +NPVWNE  E+DL+GIPL
Sbjct: 1    MLCCLLVRASNLPSAKKDRRSDPVASLTFRGVKKRTKVIKNSVNPVWNEGFEWDLKGIPL 60

Query: 60   DFSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKGQDTGATID 119
            D  S L ++VKD ET+G+N+ +G A V L+++    S S  +    LL+ K Q TGA++ 
Sbjct: 61   DQGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNA-PLLDTKKQPTGASLV 119

Query: 120  LVIGYDP-----PSAPHPNDLS-GPSVPGM-----GGDGEEDE----------------- 151
            L + Y P     P  P P  L   P++P +     GG    +                  
Sbjct: 120  LQVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVAGGGQSRAETWSLLSDSTMDTRYSGKK 179

Query: 152  --------GDEDRLDNAVRGPGPK-------GPVGTVSEAQLA----------RRLTKVK 186
                    G+ED  D  + G   +       GP    +  +L           +R     
Sbjct: 180  WPAPTDTGGEEDTEDQGLTGDEAEPFLDQSGGPGAPTTPRKLPSRPPPHYPGIKRKRSAP 239

Query: 187  NSRRMLSNKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNNPFFDELFF 246
             SR++LS+KPQDFQIRV+VIEGRQL G NI+PVVKV   GQT RTRI +GN+P F+E  F
Sbjct: 240  TSRKLLSDKPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKGNSPLFNETLF 299

Query: 247  YNVNMTPSELMDEIISIRVYNSHSLRADCLMGEFKIDVGFVYDEPGHAVMRKWLLLNDPE 306
            +N+  +P EL DE I I V +S SLR D L+GEF++DVG +Y EP HA +RKWLLL+DP+
Sbjct: 300  FNLFDSPGELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPD 359

Query: 307  DTSSGSKGYMKVSMFVLGTGDEPPPERRDRDNDSDDVESNLLLPAGIALRWVTFLLKIYR 366
            D S+G++GY+K S+ VLG GDE P ER+D   D +D+ESNLL P G+ALR   F LK++R
Sbjct: 360  DFSAGARGYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALRGAHFCLKVFR 419

Query: 367  AEDIPQMDDAFSQTVKEIFGGNADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVVN 426
            AED+PQMDDA    VK+IFG  ++KKNLVDPFVEVSFAGK +C+ I+EK ANP+WNQ + 
Sbjct: 420  AEDLPQMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNIT 479

Query: 427  LQIKFPSVCEKIKLTIYDWDRLTKNDVVGTTYLHLSKIAASGGEVEVNTGETEVGFVPTF 486
            L   FPS+CEK+++ I DWDRLT ND+V TTYL +SKI+A GGE+EV   +  +GF+PTF
Sbjct: 480  LPAMFPSMCEKMRIRIIDWDRLTHNDIVATTYLSMSKISAPGGEIEV---DDYLGFLPTF 536

Query: 487  GPCYLNLYGSPREYTGFPDPYDELNTGKGEGVAYRGRILVELATFLEKTPPDKKLEPISN 546
            GPCY+NLYGSPRE+TGFPDPY ELNTGKGEGVAYRGR+L+ L T L +   ++K+E +  
Sbjct: 537  GPCYINLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVE-HSEQKVEDLPA 595

Query: 547  DDLLVVEKYQRRRKYSLSAVFHSATMLQDVGEAIQFEVSIGNYGNKFDTTCKPLASTTQY 606
            DD+L VEKY RRRKYSL A F+SATMLQDV +AIQFEVSIGNYGNKFD TC PLASTTQY
Sbjct: 596  DDILRVEKYLRRRKYSLFAAFYSATMLQDVDDAIQFEVSIGNYGNKFDMTCLPLASTTQY 655

Query: 607  SRAVFDGNYYYYLPWAHTKPVVTLTSYWEDISHRLDAVNTLLAMAERLQTNIEALKSGIQ 666
            SRAVFDG +YYYLPW + KPVV L+SYWEDISHR++  N LL +A+RL+  +E +   ++
Sbjct: 656  SRAVFDGCHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLGIADRLEAGLEQVHLALK 715

Query: 667  GKIPANQLAELWLKLIDEVIEDTRYTLPLTEGKANVTVLDTQIRKLRSRSLSQIHEAAVR 726
             +     +  L  +L DE+I      L       + T LD  + +LR+  LSQI EAA+ 
Sbjct: 716  AQCSTEDVDSLVAQLTDELIAGCSQPLGDIHETPSATHLDQYLYQLRTHHLSQITEAALA 775

Query: 727  MRSEATDVKSTLAEIEDWLDKLMQLTEEPQNSMPDIIIWMIRGEKRLAYARIPAHQVLYS 786
            ++   +++ + L + EDWL +L  L EEPQNS+PDI+IWM++G+KR+AY R+PAHQVL+S
Sbjct: 776  LKLGHSELPAALEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFS 835

Query: 787  TSGENASGKYCGKTQTIFLKYPQEKNNGPKVPVELRVNIWLGLSAVEKKFNSFAEGTFTV 846
              G N  GK CGK QTIFLKYP EK  G ++PV++RV +W GLS  EK+FN FAEG  +V
Sbjct: 836  RRGANYCGKNCGKLQTIFLKYPMEKVPGARMPVQIRVKLWFGLSVDEKEFNQFAEGKLSV 895

Query: 847  FAEMYENQA--LMFGKWGTSGLVGRHKFSDVTGKIKLKREFFLPPKGWEWEGEWIVDPER 904
            FAE YEN+    + G WGT+GL    KFSDVTGKIKL ++ F P  GW W G+W V PE+
Sbjct: 896  FAETYENETKLALVGNWGTTGLT-YPKFSDVTGKIKLPKDSFRPSAGWTWAGDWFVCPEK 954

Query: 905  SLLTEADAGHTEFTDEVYQNESRYPGGDWKPAEDTYTDANGDKAASPSELTCPPGWEWED 964
            +LL + DAGH  F +EV++N++R PGG W    D YTD NG+K     ++ CP GW+WED
Sbjct: 955  TLLHDMDAGHLSFVEEVFENQTRLPGGQWIYMSDNYTDVNGEKVLPKDDIECPLGWKWED 1014

Query: 965  DAWSYDINRAVDEKGWEYGITIPPDHKPKSWVAAEKMYHTHRRRRLVRKRKKDLTQTASS 1024
            + WS D+NRAVDE+GWEY ITIPP+ KPK WV AEKMY+THRRRR VR R++DL+Q  + 
Sbjct: 1015 EEWSTDLNRAVDEQGWEYSITIPPERKPKHWVPAEKMYYTHRRRRWVRLRRRDLSQMEAL 1074

Query: 1025 TARAMEELQDQEGWEYASLIGWKFHWKQRSSDTFRRRRWRRKMAPSETHGAAAIFKLEGA 1084
                  E +  EGWEYASL GWKFH + R +D FRRRRWRR+M P E  G AA+F LEGA
Sbjct: 1075 KRHRQAEAEG-EGWEYASLFGWKFHLEYRKTDAFRRRRWRRRMEPLEKTGPAAVFALEGA 1133

Query: 1085 LGADTTEDGDEKSLEKQKHSATTVFGANTPIVSCNFDRVYIYHLRCYVYQARNLLALDKD 1144
            LG       D+KS E     +T  FG N P +SC FD    YHLRCY+YQAR+L A+DKD
Sbjct: 1134 LGGVM----DDKS-EDSMSVSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMDKD 1188

Query: 1145 SFSDPYAHICFLHRSKTTEIIHSTLNPTWDQTIIFDEVEIYGEPQTVLQNPPKVIMELFD 1204
            SFSDPYA + FLH+S+ T ++ +TLNPTWDQT+IF E+EI+GEP TV + PP +++EL+D
Sbjct: 1189 SFSDPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYD 1248

Query: 1205 NDQVGKDEFLGRSIFSPVVKLNSEMDITPKLLWHPVMNGDKACGDVLVTAELILRGK--- 1261
            +D  G DEF+GR I  P       ++  P+L W P+  G +  G++L + ELI R K   
Sbjct: 1249 HDTYGADEFMGRCICQP------SLERMPRLAWFPLTRGSQPSGELLASFELIQREKPAI 1302

Query: 1262 ------------------DGSNLPILPPQRAPNLYMVPQGIRPVVQLTAIEILAWGLRNM 1303
                              + ++LP  PPQR  N+YMVPQ I+P +Q TAIEILAWGLRNM
Sbjct: 1303 HHIPGFEVQETSRILDESEDTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNM 1362

Query: 1304 KNFQMASITSPSLVVECGGERVESVVIKNLKKTPNFPSSVLFMKVFLPKEELYMPPLVIK 1363
            K++Q+A+I+SPSLVVECGG+ V+S VI+NL+K PNF    LFM+V LP+EELY PP+ +K
Sbjct: 1363 KSYQLANISSPSLVVECGGQTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVK 1422

Query: 1364 VIDHRQFGRKPVVGQCTIERLDRFRCDPYAGKEDIVPQ---LKASLLSAPPCRDIVIEME 1420
            VID+RQFGR+PVVGQCTI  L+ F CDPY+  E   PQ      SLLS  P  D++I+++
Sbjct: 1423 VIDNRQFGRRPVVGQCTIRSLESFLCDPYSA-ESPSPQGGPDDVSLLS--PGEDVLIDID 1479

Query: 1421 DTKPLLASKLTEKEEEIVDWWSKFYASSGEHEKCGQYIQKGYSKLKIYNCELENVAEFEG 1480
            D +PL+      +EEE +DWWSKF+AS GE EKCG Y++K +  LK+Y+ +LENV  FEG
Sbjct: 1480 DKEPLIPI----QEEEFIDWWSKFFASIGEREKCGSYLEKDFDTLKVYDTQLENVEAFEG 1535

Query: 1481 LTDFSDTFKLYRGKS-DENEDPSVVGEFKGSFRIYPLPDDPSVPAPPRQFRELPDSVPQE 1539
            L+DF +TFKLYRGK+ +E EDPSV+GEFKG F+IYPLP+DP++P PPRQF +L    PQE
Sbjct: 1536 LSDFCNTFKLYRGKTQEETEDPSVIGEFKGLFKIYPLPEDPAIPMPPRQFHQLAAQGPQE 1595

Query: 1540 CTVRIYIVRGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYL 1599
            C VRIYIVR   LQP+D NG CDPYIKI++GKK + D+D+YIP TL PVFG+M+EL+C L
Sbjct: 1596 CLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTL 1655

Query: 1600 PQEKDLKISVYDYDTFTRDEKVGETIIDLENRFLSRFGSHCGIPEEYCVSGVNTWRDQLR 1659
            P EKDLKI++YDYD  ++DEK+GET++DLENR LS+FG+ CG+P+ YCVSG N WRDQLR
Sbjct: 1656 PLEKDLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLR 1715

Query: 1660 PTQLLQNVARFKGFPQPILSEDGSRIRYGGRDYSLDEFEANKILHQHLGAPEERLALHIL 1719
            P+QLL    +      P+   D  R+ +  ++YS++E EA +I + HLG  EERLALH+L
Sbjct: 1716 PSQLLHLFCQQHRVKAPVYRTD--RVMFQDKEYSIEEIEAGRIPNPHLGPVEERLALHVL 1773

Query: 1720 RTQGLVPEHVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGPPFNITPRKAKKYYLRV 1779
            + QGLVPEHVE+R L+S  QP+I QGKLQMWVD+FPK+LG PGPPFNITPR+A++++LR 
Sbjct: 1774 QQQGLVPEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRC 1833

Query: 1780 IIWNTKDVILDEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYRSLDGEGNFNWRFVFPF 1839
            IIWNT+DVILD+ S+TGE+MSDIYVKGW+ G EE+KQKTDVHYRSL GEGNFNWRF+FPF
Sbjct: 1834 IIWNTRDVILDDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPF 1893

Query: 1840 DYLPAEQLCIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSLDDYLGFLELDLRHTIIP 1899
            DYLPAEQ+C +AKK+ FW +D+TE +IP R++ QIWDNDKFS DD+LG L+LDL     P
Sbjct: 1894 DYLPAEQVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKP 1953

Query: 1900 AKSPEKCRLDMIPDLKAMNPLKAKTASLFEQKSMKGWWPCYAEKDGARVMAGKVEMTLEI 1959
            AK+ +KC LD + D  A +P      SLFEQK++KGWWPC AE+   +++AGK+EMTLEI
Sbjct: 1954 AKTAKKCSLDQLDD--AFHP--EWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEMTLEI 2009

Query: 1960 LNEKEADERPAGKGRDEPNMNPKLDLPNRPETSFLWFTNPCKTMKFIVWRRFKWVIIGLL 2019
            + E E +ERPAG+GRDEPNMNPKL+ P RP+TSFLWFT+P KTMKFI+WRRF+W II  +
Sbjct: 2010 VAESEHEERPAGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFI 2069

Query: 2020 FLLILLLFVAVLLYSLPNYLSMKIVKP 2046
             L ILLLF+A+ +Y+ PNY +MK+VKP
Sbjct: 2070 ILFILLLFLAIFIYAFPNYAAMKLVKP 2096


>gi|195976756 dysferlin isoform 10 [Homo sapiens]
          Length = 2087

 Score = 2380 bits (6167), Expect = 0.0
 Identities = 1179/2112 (55%), Positives = 1511/2112 (71%), Gaps = 93/2112 (4%)

Query: 1    MLRVIVESASNIPKTKFGKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLD 60
            MLRV +  A N+        D   S +F   KK+TK + N +NPVWNE  E+DL+GIPLD
Sbjct: 1    MLRVFILYAENVHTPDTDISDAYCSAVFAGVKKRTKVIKNSVNPVWNEGFEWDLKGIPLD 60

Query: 61   FSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKGQDTGATIDL 120
              S L ++VKD ET+G+N+ +G A V L+++    S S  +    LL+ K Q TGA++ L
Sbjct: 61   QGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNA-PLLDTKKQPTGASLVL 119

Query: 121  VIGYDP-----PSAPHPNDLS-GPSVPGMG----GDGEEDEGDEDRLDNAVR-------G 163
             + Y P     P  P P  L   P++P +       GEED  D+    +          G
Sbjct: 120  QVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVADTGGEEDTEDQGLTGDEAEPFLDQSGG 179

Query: 164  PGP-----KGPVGTVSEAQLARRLTKVKNSRRMLSNKPQDFQIRVRVIEGRQLSGNNIRP 218
            PG      K P          +R      SR++LS+KPQDFQIRV+VIEGRQL G NI+P
Sbjct: 180  PGAPTTPRKLPSRPPPHYPGIKRKRSAPTSRKLLSDKPQDFQIRVQVIEGRQLPGVNIKP 239

Query: 219  VVKVHVCGQTHRTRIKRGNNPFFDELFFYNVNMTPSELMDEIISIRVYNSHSLRADCLMG 278
            VVKV   GQT RTRI +GN+P F+E  F+N+  +P EL DE I I V +S SLR D L+G
Sbjct: 240  VVKVTAAGQTKRTRIHKGNSPLFNETLFFNLFDSPGELFDEPIFITVVDSRSLRTDALLG 299

Query: 279  EFKIDVGFVYDEPGHAVMRKWLLLNDPEDTSSGSKGYMKVSMFVLGTGDEPPPERRDRDN 338
            EF++DVG +Y EP HA +RKWLLL+DP+D S+G++GY+K S+ VLG GDE P ER+D   
Sbjct: 300  EFRMDVGTIYREPRHAYLRKWLLLSDPDDFSAGARGYLKTSLCVLGPGDEAPLERKDPSE 359

Query: 339  DSDDVESNLLLPAGIALRWVTFLLKIYRAEDIPQMDDAFSQTVKEIFGGNADKKNLVDPF 398
            D +D+ESNLL P G+ALR   F LK++RAED+PQMDDA    VK+IFG  ++KKNLVDPF
Sbjct: 360  DKEDIESNLLRPTGVALRGAHFCLKVFRAEDLPQMDDAVMDNVKQIFGFESNKKNLVDPF 419

Query: 399  VEVSFAGKKVCTNIIEKNANPEWNQVVNLQIKFPSVCEKIKLTIYDWDRLTKNDVVGTTY 458
            VEVSFAGK +C+ I+EK ANP+WNQ + L   FPS+CEK+++ I DWDRLT ND+V TTY
Sbjct: 420  VEVSFAGKMLCSKILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDIVATTY 479

Query: 459  LHLSKIAASGGEVEVNTGETEVGFVPTFGPCYLNLYGSPREYTGFPDPYDELNTGKGEGV 518
            L +SKI+A GGE+EV   +  +GF+PTFGPCY+NLYGSPRE+TGFPDPY ELNTGKGEGV
Sbjct: 480  LSMSKISAPGGEIEV---DDYLGFLPTFGPCYINLYGSPREFTGFPDPYTELNTGKGEGV 536

Query: 519  AYRGRILVELATFLEKTPPDKKLEPISNDDLLVVEKYQRRRKYSLSAVFHSATMLQDVGE 578
            AYRGR+L+ L T L +   ++K+E +  DD+L VEKY RRRKYSL A F+SATMLQDV +
Sbjct: 537  AYRGRLLLSLETKLVE-HSEQKVEDLPADDILRVEKYLRRRKYSLFAAFYSATMLQDVDD 595

Query: 579  AIQFEVSIGNYGNKFDTTCKPLASTTQYSRAVFDGNYYYYLPWAHTKPVVTLTSYWEDIS 638
            AIQFEVSIGNYGNKFD TC PLASTTQYSRAVFDG +YYYLPW + KPVV L+SYWEDIS
Sbjct: 596  AIQFEVSIGNYGNKFDMTCLPLASTTQYSRAVFDGCHYYYLPWGNVKPVVVLSSYWEDIS 655

Query: 639  HRLDAVNTLLAMAERLQTNIEALKSGIQGKIPANQLAELWLKLIDEVIEDTRYTLPLTEG 698
            HR++  N LL +A+RL+  +E +   ++ +     +  L  +L DE+I      L     
Sbjct: 656  HRIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQPLGDIHE 715

Query: 699  KANVTVLDTQIRKLRSRSLSQIHEAAVRMRSEATDVKSTLAEIEDWLDKLMQLTEEPQNS 758
              + T LD  + +LR+  LSQI EAA+ ++   +++ + L + EDWL +L  L EEPQNS
Sbjct: 716  TPSATHLDQYLYQLRTHHLSQITEAALALKLGHSELPAALEQAEDWLLRLRALAEEPQNS 775

Query: 759  MPDIIIWMIRGEKRLAYARIPAHQVLYSTSGENASGKYCGKTQTIFLKYPQEKNNGPKVP 818
            +PDI+IWM++G+KR+AY R+PAHQVL+S  G N  GK CGK QTIFLKYP EK  G ++P
Sbjct: 776  LPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKYPMEKVPGARMP 835

Query: 819  VELRVNIWLGLSAVEKKFNSFAEGTFTVFAEMYENQA--LMFGKWGTSGLVGRHKFSDVT 876
            V++RV +W GLS  EK+FN FAEG  +VFAE YEN+    + G WGT+GL    KFSDVT
Sbjct: 836  VQIRVKLWFGLSVDEKEFNQFAEGKLSVFAETYENETKLALVGNWGTTGLT-YPKFSDVT 894

Query: 877  GKIKLKREFFLPPKGWEWEGEWIVDPERSLLTEADAGHTEFTDEVYQNESRYPGGDWKPA 936
            GKIKL ++ F P  GW W G+W V PE++LL + DAGH  F +EV++N++R PGG W   
Sbjct: 895  GKIKLPKDSFRPSAGWTWAGDWFVCPEKTLLHDMDAGHLSFVEEVFENQTRLPGGQWIYM 954

Query: 937  EDTYTDANGDKAASPSELTCPPGWEWEDDAWSYDINRAVDEKGWEYGITIPPDHKPKSWV 996
             D YTD NG+K     ++ CP GW+WED+ WS D+NRAVDE+GWEY ITIPP+ KPK WV
Sbjct: 955  SDNYTDVNGEKVLPKDDIECPLGWKWEDEEWSTDLNRAVDEQGWEYSITIPPERKPKHWV 1014

Query: 997  AAEKMYHTHRRRRLVRKRKKDLTQTASSTARAMEELQDQEGWEYASLIGWKFHWKQRSSD 1056
             AEKMY+THRRRR VR R++DL+Q  +       E +  EGWEYASL GWKFH + R +D
Sbjct: 1015 PAEKMYYTHRRRRWVRLRRRDLSQMEALKRHRQAEAEG-EGWEYASLFGWKFHLEYRKTD 1073

Query: 1057 TFRRRRWRRKMAPSETHGAAAIFKLEGALGADTTEDGDEKSLEKQKHSATTVFGANTPIV 1116
             FRRRRWRR+M P E  G AA+F LEGALG       D+KS E     +T  FG N P +
Sbjct: 1074 AFRRRRWRRRMEPLEKTGPAAVFALEGALGGVM----DDKS-EDSMSVSTLSFGVNRPTI 1128

Query: 1117 SCNFDRVYIYHLRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTWDQT 1176
            SC FD    YHLRCY+YQAR+L A+DKDSFSDPYA + FLH+S+ T ++ +TLNPTWDQT
Sbjct: 1129 SCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTWDQT 1188

Query: 1177 IIFDEVEIYGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVVKLNSEMDITPKLL 1236
            +IF E+EI+GEP TV + PP +++EL+D+D  G DEF+GR I  P       ++  P+L 
Sbjct: 1189 LIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQP------SLERMPRLA 1242

Query: 1237 WHPVMNGDKACGDVLVTAELILRGK---------------------DGSNLPILPPQRAP 1275
            W P+  G +  G++L + ELI R K                     + ++LP  PPQR  
Sbjct: 1243 WFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDTDLPYPPPQREA 1302

Query: 1276 NLYMVPQGIRPVVQLTAIEILAWGLRNMKNFQMASITSPSLVVECGGERVESVVIKNLKK 1335
            N+YMVPQ I+P +Q TAIEILAWGLRNMK++Q+A+I+SPSLVVECGG+ V+S VI+NL+K
Sbjct: 1303 NIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQTVQSCVIRNLRK 1362

Query: 1336 TPNFPSSVLFMKVFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTIERLDRFRCDPYAGK 1395
             PNF    LFM+V LP+EELY PP+ +KVID+RQFGR+PVVGQCTI  L+ F CDPY+  
Sbjct: 1363 NPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSLESFLCDPYSA- 1421

Query: 1396 EDIVPQ---LKASLLSAPPCRDIVIEMEDTKPLLASKLTE-----------------KEE 1435
            E   PQ      SLLS  P  D++I+++D +PL+  +L +                  EE
Sbjct: 1422 ESPSPQGGPDDVSLLS--PGEDVLIDIDDKEPLIPIQLADGLSSLAPTNTASPPSSPHEE 1479

Query: 1436 EIVDWWSKFYASSGEHEKCGQYIQKGYSKLKIYNCELENVAEFEGLTDFSDTFKLYRGKS 1495
            E +DWWSKF+AS GE EKCG Y++K +  LK+Y+ +LENV  FEGL+DF +TFKLYRGK+
Sbjct: 1480 EFIDWWSKFFASIGEREKCGSYLEKDFDTLKVYDTQLENVEAFEGLSDFCNTFKLYRGKT 1539

Query: 1496 -DENEDPSVVGEFKGSFRIYPLPDDPSVPAPPRQFRELPDSVPQECTVRIYIVRGLELQP 1554
             +E EDPSV+GEFKG F+IYPLP+DP++P PPRQF +L    PQEC VRIYIVR   LQP
Sbjct: 1540 QEETEDPSVIGEFKGLFKIYPLPEDPAIPMPPRQFHQLAAQGPQECLVRIYIVRAFGLQP 1599

Query: 1555 QDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLPQEKDLKISVYDYDT 1614
            +D NG CDPYIKI++GKK + D+D+YIP TL PVFG+M+EL+C LP EKDLKI++YDYD 
Sbjct: 1600 KDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDL 1659

Query: 1615 FTRDEKVGETIIDLENRFLSRFGSHCGIPEEYCVSGVNTWRDQLRPTQLLQNVARFKGFP 1674
             ++DEK+GET++DLENR LS+FG+ CG+P+ YCVSG N WRDQLRP+QLL    +     
Sbjct: 1660 LSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVK 1719

Query: 1675 QPILSEDGSRIRYGGRDYSLDEFEANKILHQHLGAPEERLALHILRTQGLVPEHVETRTL 1734
             P+   D  R+ +  ++YS++E EA +I + HLG  EERLALH+L+ QGLVPEHVE+R L
Sbjct: 1720 APVYRTD--RVMFQDKEYSIEEIEAGRIPNPHLGPVEERLALHVLQQQGLVPEHVESRPL 1777

Query: 1735 HSTFQPNISQGKLQMWVDVFPKSLGPPGPPFNITPRKAKKYYLRVIIWNTKDVILDEKSI 1794
            +S  QP+I QGKLQMWVD+FPK+LG PGPPFNITPR+A++++LR IIWNT+DVILD+ S+
Sbjct: 1778 YSPLQPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVILDDLSL 1837

Query: 1795 TGEEMSDIYVKGWIPGNEENKQKTDVHYRSLDGEGNFNWRFVFPFDYLPAEQLCIVAKKE 1854
            TGE+MSDIYVKGW+ G EE+KQKTDVHYRSL GEGNFNWRF+FPFDYLPAEQ+C +AKK+
Sbjct: 1838 TGEKMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKD 1897

Query: 1855 HFWSIDQTEFRIPPRLIIQIWDNDKFSLDDYLGFLELDLRHTIIPAKSPEKCRLDMIPDL 1914
             FW +D+TE +IP R++ QIWDNDKFS DD+LG L+LDL     PAK+ +KC LD + D 
Sbjct: 1898 AFWRLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDD- 1956

Query: 1915 KAMNPLKAKTASLFEQKSMKGWWPCYAEKDGARVMAGKVEMTLEILNEKEADERPAGKGR 1974
             A +P      SLFEQK++KGWWPC AE+   +++AGK+EMTLEI+ E E +ERPAG+GR
Sbjct: 1957 -AFHP--EWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEMTLEIVAESEHEERPAGQGR 2013

Query: 1975 DEPNMNPKLDLPNRPETSFLWFTNPCKTMKFIVWRRFKWVIIGLLFLLILLLFVAVLLYS 2034
            DEPNMNPKL+ P RP+TSFLWFT+P KTMKFI+WRRF+W II  + L ILLLF+A+ +Y+
Sbjct: 2014 DEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYA 2073

Query: 2035 LPNYLSMKIVKP 2046
             PNY +MK+VKP
Sbjct: 2074 FPNYAAMKLVKP 2085


>gi|195976769 dysferlin isoform 6 [Homo sapiens]
          Length = 2102

 Score = 2379 bits (6166), Expect = 0.0
 Identities = 1180/2124 (55%), Positives = 1516/2124 (71%), Gaps = 102/2124 (4%)

Query: 1    MLRVIVESASNIPKTKFGK-PDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPL 59
            ML  ++  ASN+P  K  +  DP+ S+ F+  KK+TK + N +NPVWNE  E+DL+GIPL
Sbjct: 1    MLCCLLVRASNLPSAKKDRRSDPVASLTFRGVKKRTKVIKNSVNPVWNEGFEWDLKGIPL 60

Query: 60   DFSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKGQDTGATID 119
            D  S L ++VKD ET+G+N+ +G A V L+++    S S  +    LL+ K Q TGA++ 
Sbjct: 61   DQGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNA-PLLDTKKQPTGASLV 119

Query: 120  LVIGYDP-----PSAPHPNDLS-GPSVPGMG----GDGEEDEGDEDRLDNAVR------- 162
            L + Y P     P  P P  L   P++P +       GEED  D+    +          
Sbjct: 120  LQVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVADTGGEEDTEDQGLTGDEAEPFLDQSG 179

Query: 163  GPGP-----KGPVGTVSEAQLARRLTKVKNSRRMLSNKPQDFQIRVRVIEGRQLSGNNIR 217
            GPG      K P          +R      SR++LS+KPQDFQIRV+VIEGRQL G NI+
Sbjct: 180  GPGAPTTPRKLPSRPPPHYPGIKRKRSAPTSRKLLSDKPQDFQIRVQVIEGRQLPGVNIK 239

Query: 218  PVVKVHVCGQTHRTRIKRGNNPFFDELFFYNVNMTPSELMDEIISIRVYNSHSLRADCLM 277
            PVVKV   GQT RTRI +GN+P F+E  F+N+  +P EL DE I I V +S SLR D L+
Sbjct: 240  PVVKVTAAGQTKRTRIHKGNSPLFNETLFFNLFDSPGELFDEPIFITVVDSRSLRTDALL 299

Query: 278  GEFKIDVGFVYDEPGHAVMRKWLLLNDPEDTSSGSKGYMKVSMFVLGTGDEPPPERRDRD 337
            GEF++DVG +Y EP HA +RKWLLL+DP+D S+G++GY+K S+ VLG GDE P ER+D  
Sbjct: 300  GEFRMDVGTIYREPRHAYLRKWLLLSDPDDFSAGARGYLKTSLCVLGPGDEAPLERKDPS 359

Query: 338  NDSDDVESNLLLPAGIALRWVTFLLKIYRAEDIPQMDDAFSQTVKEIFGGNADKKNLVDP 397
             D +D+ESNLL P G+ALR   F LK++RAED+PQMDDA    VK+IFG  ++KKNLVDP
Sbjct: 360  EDKEDIESNLLRPTGVALRGAHFCLKVFRAEDLPQMDDAVMDNVKQIFGFESNKKNLVDP 419

Query: 398  FVEVSFAGKKVCTNIIEKNANPEWNQVVNLQIKFPSVCEKIKLTIYDWDRLTKNDVVGTT 457
            FVEVSFAGK +C+ I+EK ANP+WNQ + L   FPS+CEK+++ I DWDRLT ND+V TT
Sbjct: 420  FVEVSFAGKMLCSKILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDIVATT 479

Query: 458  YLHLSKIAASGGEVEVNTG-----------ETEVGFVPTFGPCYLNLYGSPREYTGFPDP 506
            YL +SKI+A GGE+E               +  +GF+PTFGPCY+NLYGSPRE+TGFPDP
Sbjct: 480  YLSMSKISAPGGEIEEEPAGAVKPSKASDLDDYLGFLPTFGPCYINLYGSPREFTGFPDP 539

Query: 507  YDELNTGKGEGVAYRGRILVELATFLEKTPPDKKLEPISNDDLLVVEKYQRRRKYSLSAV 566
            Y ELNTGKGEGVAYRGR+L+ L T L +   ++K+E +  DD+L VEKY RRRKYSL A 
Sbjct: 540  YTELNTGKGEGVAYRGRLLLSLETKLVE-HSEQKVEDLPADDILRVEKYLRRRKYSLFAA 598

Query: 567  FHSATMLQDVGEAIQFEVSIGNYGNKFDTTCKPLASTTQYSRAVFDGNYYYYLPWAHTKP 626
            F+SATMLQDV +AIQFEVSIGNYGNKFD TC PLASTTQYSRAVFDG +YYYLPW + KP
Sbjct: 599  FYSATMLQDVDDAIQFEVSIGNYGNKFDMTCLPLASTTQYSRAVFDGCHYYYLPWGNVKP 658

Query: 627  VVTLTSYWEDISHRLDAVNTLLAMAERLQTNIEALKSGIQGKIPANQLAELWLKLIDEVI 686
            VV L+SYWEDISHR++  N LL +A+RL+  +E +   ++ +     +  L  +L DE+I
Sbjct: 659  VVVLSSYWEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQLTDELI 718

Query: 687  EDTRYTLPLTEGKANVTVLDTQIRKLRSRSLSQIHEAAVRMRSEATDVKSTLAEIEDWLD 746
                  L       + T LD  + +LR+  LSQI EAA+ ++   +++ + L + EDWL 
Sbjct: 719  AGCSQPLGDIHETPSATHLDQYLYQLRTHHLSQITEAALALKLGHSELPAALEQAEDWLL 778

Query: 747  KLMQLTEEPQNSMPDIIIWMIRGEKRLAYARIPAHQVLYSTSGENASGKYCGKTQTIFLK 806
            +L  L EEPQNS+PDI+IWM++G+KR+AY R+PAHQVL+S  G N  GK CGK QTIFLK
Sbjct: 779  RLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFLK 838

Query: 807  YPQEKNNGPKVPVELRVNIWLGLSAVEKKFNSFAEGTFTVFAEMYENQA--LMFGKWGTS 864
            YP EK  G ++PV++RV +W GLS  EK+FN FAEG  +VFAE YEN+    + G WGT+
Sbjct: 839  YPMEKVPGARMPVQIRVKLWFGLSVDEKEFNQFAEGKLSVFAETYENETKLALVGNWGTT 898

Query: 865  GLVGRHKFSDVTGKIKLKREFFLPPKGWEWEGEWIVDPERSLLTEADAGHTEFTDEVYQN 924
            GL    KFSDVTGKIKL ++ F P  GW W G+W V PE++LL + DAGH  F +EV++N
Sbjct: 899  GLT-YPKFSDVTGKIKLPKDSFRPSAGWTWAGDWFVCPEKTLLHDMDAGHLSFVEEVFEN 957

Query: 925  ESRYPGGDWKPAEDTYTDANGDKAASPSELTCPPGWEWEDDAWSYDINRAVDEKGWEYGI 984
            ++R PGG W    D YTD NG+K     ++ CP GW+WED+ WS D+NRAVDE+GWEY I
Sbjct: 958  QTRLPGGQWIYMSDNYTDVNGEKVLPKDDIECPLGWKWEDEEWSTDLNRAVDEQGWEYSI 1017

Query: 985  TIPPDHKPKSWVAAEKMYHTHRRRRLVRKRKKDLTQTASSTARAMEELQDQEGWEYASLI 1044
            TIPP+ KPK WV AEKMY+THRRRR VR R++DL+Q  +       E +  EGWEYASL 
Sbjct: 1018 TIPPERKPKHWVPAEKMYYTHRRRRWVRLRRRDLSQMEALKRHRQAEAEG-EGWEYASLF 1076

Query: 1045 GWKFHWKQRSSDTFRRRRWRRKMAPSETHGAAAIFKLEGALGADTTEDGDEKSLEKQKHS 1104
            GWKFH + R +D FRRRRWRR+M P E  G AA+F LEGALG       D+KS E     
Sbjct: 1077 GWKFHLEYRKTDAFRRRRWRRRMEPLEKTGPAAVFALEGALGGVM----DDKS-EDSMSV 1131

Query: 1105 ATTVFGANTPIVSCNFDRVYIYHLRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTEI 1164
            +T  FG N P +SC FD    YHLRCY+YQAR+L A+DKDSFSDPYA + FLH+S+ T +
Sbjct: 1132 STLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVV 1191

Query: 1165 IHSTLNPTWDQTIIFDEVEIYGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVVK 1224
            + +TLNPTWDQT+IF E+EI+GEP TV + PP +++EL+D+D  G DEF+GR I  P   
Sbjct: 1192 VKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQP--- 1248

Query: 1225 LNSEMDITPKLLWHPVMNGDKACGDVLVTAELILRGK---------------------DG 1263
                ++  P+L W P+  G +  G++L + ELI R K                     + 
Sbjct: 1249 ---SLERMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESED 1305

Query: 1264 SNLPILPPQRAPNLYMVPQGIRPVVQLTAIEILAWGLRNMKNFQMASITSPSLVVECGGE 1323
            ++LP  PPQR  N+YMVPQ I+P +Q TAIEILAWGLRNMK++Q+A+I+SPSLVVECGG+
Sbjct: 1306 TDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQ 1365

Query: 1324 RVESVVIKNLKKTPNFPSSVLFMKVFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTIER 1383
             V+S VI+NL+K PNF    LFM+V LP+EELY PP+ +KVID+RQFGR+PVVGQCTI  
Sbjct: 1366 TVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRS 1425

Query: 1384 LDRFRCDPYAGKEDIVPQ---LKASLLSAPPCRDIVIEMEDTKPLLASKLTE-------- 1432
            L+ F CDPY+  E   PQ      SLLS  P  D++I+++D +PL+  +L +        
Sbjct: 1426 LESFLCDPYSA-ESPSPQGGPDDVSLLS--PGEDVLIDIDDKEPLIPIQLADGLSSLAPT 1482

Query: 1433 ---------KEEEIVDWWSKFYASSGEHEKCGQYIQKGYSKLKIYNCELENVAEFEGLTD 1483
                      EEE +DWWSKF+AS GE EKCG Y++K +  LK+Y+ +LENV  FEGL+D
Sbjct: 1483 NTASPPSSPHEEEFIDWWSKFFASIGEREKCGSYLEKDFDTLKVYDTQLENVEAFEGLSD 1542

Query: 1484 FSDTFKLYRGKS-DENEDPSVVGEFKGSFRIYPLPDDPSVPAPPRQFRELPDSVPQECTV 1542
            F +TFKLYRGK+ +E EDPSV+GEFKG F+IYPLP+DP++P PPRQF +L    PQEC V
Sbjct: 1543 FCNTFKLYRGKTQEETEDPSVIGEFKGLFKIYPLPEDPAIPMPPRQFHQLAAQGPQECLV 1602

Query: 1543 RIYIVRGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLPQE 1602
            RIYIVR   LQP+D NG CDPYIKI++GKK + D+D+YIP TL PVFG+M+EL+C LP E
Sbjct: 1603 RIYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLE 1662

Query: 1603 KDLKISVYDYDTFTRDEKVGETIIDLENRFLSRFGSHCGIPEEYCVSGVNTWRDQLRPTQ 1662
            KDLKI++YDYD  ++DEK+GET++DLENR LS+FG+ CG+P+ YCVSG N WRDQLRP+Q
Sbjct: 1663 KDLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQ 1722

Query: 1663 LLQNVARFKGFPQPILSEDGSRIRYGGRDYSLDEFEANKILHQHLGAPEERLALHILRTQ 1722
            LL    +      P+   D  R+ +  ++YS++E EA +I + HLG  EERLALH+L+ Q
Sbjct: 1723 LLHLFCQQHRVKAPVYRTD--RVMFQDKEYSIEEIEAGRIPNPHLGPVEERLALHVLQQQ 1780

Query: 1723 GLVPEHVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGPPFNITPRKAKKYYLRVIIW 1782
            GLVPEHVE+R L+S  QP+I QGKLQMWVD+FPK+LG PGPPFNITPR+A++++LR IIW
Sbjct: 1781 GLVPEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIW 1840

Query: 1783 NTKDVILDEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYRSLDGEGNFNWRFVFPFDYL 1842
            NT+DVILD+ S+TGE+MSDIYVKGW+ G EE+KQKTDVHYRSL GEGNFNWRF+FPFDYL
Sbjct: 1841 NTRDVILDDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYL 1900

Query: 1843 PAEQLCIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSLDDYLGFLELDLRHTIIPAKS 1902
            PAEQ+C +AKK+ FW +D+TE +IP R++ QIWDNDKFS DD+LG L+LDL     PAK+
Sbjct: 1901 PAEQVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKT 1960

Query: 1903 PEKCRLDMIPDLKAMNPLKAKTASLFEQKSMKGWWPCYAEKDGARVMAGKVEMTLEILNE 1962
             +KC LD + D  A +P      SLFEQK++KGWWPC AE+   +++AGK+EMTLEI+ E
Sbjct: 1961 AKKCSLDQLDD--AFHP--EWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEMTLEIVAE 2016

Query: 1963 KEADERPAGKGRDEPNMNPKLDLPNRPETSFLWFTNPCKTMKFIVWRRFKWVIIGLLFLL 2022
             E +ERPAG+GRDEPNMNPKL+ P RP+TSFLWFT+P KTMKFI+WRRF+W II  + L 
Sbjct: 2017 SEHEERPAGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILF 2076

Query: 2023 ILLLFVAVLLYSLPNYLSMKIVKP 2046
            ILLLF+A+ +Y+ PNY +MK+VKP
Sbjct: 2077 ILLLFLAIFIYAFPNYAAMKLVKP 2100


>gi|4503431 dysferlin isoform 8 [Homo sapiens]
          Length = 2080

 Score = 2377 bits (6160), Expect = 0.0
 Identities = 1177/2106 (55%), Positives = 1508/2106 (71%), Gaps = 88/2106 (4%)

Query: 1    MLRVIVESASNIPKTKFGKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLD 60
            MLRV +  A N+        D   S +F   KK+TK + N +NPVWNE  E+DL+GIPLD
Sbjct: 1    MLRVFILYAENVHTPDTDISDAYCSAVFAGVKKRTKVIKNSVNPVWNEGFEWDLKGIPLD 60

Query: 61   FSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKGQDTGATIDL 120
              S L ++VKD ET+G+N+ +G A V L+++    S S  +    LL+ K Q TGA++ L
Sbjct: 61   QGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNA-PLLDTKKQPTGASLVL 119

Query: 121  VIGYDP-----PSAPHPNDLS-GPSVPGMG----GDGEEDEGDEDRLDNAVR-------G 163
             + Y P     P  P P  L   P++P +       GEED  D+    +          G
Sbjct: 120  QVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVADTGGEEDTEDQGLTGDEAEPFLDQSGG 179

Query: 164  PGP-----KGPVGTVSEAQLARRLTKVKNSRRMLSNKPQDFQIRVRVIEGRQLSGNNIRP 218
            PG      K P          +R      SR++LS+KPQDFQIRV+VIEGRQL G NI+P
Sbjct: 180  PGAPTTPRKLPSRPPPHYPGIKRKRSAPTSRKLLSDKPQDFQIRVQVIEGRQLPGVNIKP 239

Query: 219  VVKVHVCGQTHRTRIKRGNNPFFDELFFYNVNMTPSELMDEIISIRVYNSHSLRADCLMG 278
            VVKV   GQT RTRI +GN+P F+E  F+N+  +P EL DE I I V +S SLR D L+G
Sbjct: 240  VVKVTAAGQTKRTRIHKGNSPLFNETLFFNLFDSPGELFDEPIFITVVDSRSLRTDALLG 299

Query: 279  EFKIDVGFVYDEPGHAVMRKWLLLNDPEDTSSGSKGYMKVSMFVLGTGDEPPPERRDRDN 338
            EF++DVG +Y EP HA +RKWLLL+DP+D S+G++GY+K S+ VLG GDE P ER+D   
Sbjct: 300  EFRMDVGTIYREPRHAYLRKWLLLSDPDDFSAGARGYLKTSLCVLGPGDEAPLERKDPSE 359

Query: 339  DSDDVESNLLLPAGIALRWVTFLLKIYRAEDIPQMDDAFSQTVKEIFGGNADKKNLVDPF 398
            D +D+ESNLL P G+ALR   F LK++RAED+PQMDDA    VK+IFG  ++KKNLVDPF
Sbjct: 360  DKEDIESNLLRPTGVALRGAHFCLKVFRAEDLPQMDDAVMDNVKQIFGFESNKKNLVDPF 419

Query: 399  VEVSFAGKKVCTNIIEKNANPEWNQVVNLQIKFPSVCEKIKLTIYDWDRLTKNDVVGTTY 458
            VEVSFAGK +C+ I+EK ANP+WNQ + L   FPS+CEK+++ I DWDRLT ND+V TTY
Sbjct: 420  VEVSFAGKMLCSKILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDIVATTY 479

Query: 459  LHLSKIAASGGEVEVNTG-----------ETEVGFVPTFGPCYLNLYGSPREYTGFPDPY 507
            L +SKI+A GGE+E               +  +GF+PTFGPCY+NLYGSPRE+TGFPDPY
Sbjct: 480  LSMSKISAPGGEIEEEPAGAVKPSKASDLDDYLGFLPTFGPCYINLYGSPREFTGFPDPY 539

Query: 508  DELNTGKGEGVAYRGRILVELATFLEKTPPDKKLEPISNDDLLVVEKYQRRRKYSLSAVF 567
             ELNTGKGEGVAYRGR+L+ L T L +   ++K+E +  DD+L VEKY RRRKYSL A F
Sbjct: 540  TELNTGKGEGVAYRGRLLLSLETKLVE-HSEQKVEDLPADDILRVEKYLRRRKYSLFAAF 598

Query: 568  HSATMLQDVGEAIQFEVSIGNYGNKFDTTCKPLASTTQYSRAVFDGNYYYYLPWAHTKPV 627
            +SATMLQDV +AIQFEVSIGNYGNKFD TC PLASTTQYSRAVFDG +YYYLPW + KPV
Sbjct: 599  YSATMLQDVDDAIQFEVSIGNYGNKFDMTCLPLASTTQYSRAVFDGCHYYYLPWGNVKPV 658

Query: 628  VTLTSYWEDISHRLDAVNTLLAMAERLQTNIEALKSGIQGKIPANQLAELWLKLIDEVIE 687
            V L+SYWEDISHR++  N LL +A+RL+  +E +   ++ +     +  L  +L DE+I 
Sbjct: 659  VVLSSYWEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQLTDELIA 718

Query: 688  DTRYTLPLTEGKANVTVLDTQIRKLRSRSLSQIHEAAVRMRSEATDVKSTLAEIEDWLDK 747
                 L       + T LD  + +LR+  LSQI EAA+ ++   +++ + L + EDWL +
Sbjct: 719  GCSQPLGDIHETPSATHLDQYLYQLRTHHLSQITEAALALKLGHSELPAALEQAEDWLLR 778

Query: 748  LMQLTEEPQNSMPDIIIWMIRGEKRLAYARIPAHQVLYSTSGENASGKYCGKTQTIFLKY 807
            L  L EEPQNS+PDI+IWM++G+KR+AY R+PAHQVL+S  G N  GK CGK QTIFLKY
Sbjct: 779  LRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKY 838

Query: 808  PQEKNNGPKVPVELRVNIWLGLSAVEKKFNSFAEGTFTVFAEMYENQA--LMFGKWGTSG 865
            P EK  G ++PV++RV +W GLS  EK+FN FAEG  +VFAE YEN+    + G WGT+G
Sbjct: 839  PMEKVPGARMPVQIRVKLWFGLSVDEKEFNQFAEGKLSVFAETYENETKLALVGNWGTTG 898

Query: 866  LVGRHKFSDVTGKIKLKREFFLPPKGWEWEGEWIVDPERSLLTEADAGHTEFTDEVYQNE 925
            L    KFSDVTGKIKL ++ F P  GW W G+W V PE++LL + DAGH  F +EV++N+
Sbjct: 899  LT-YPKFSDVTGKIKLPKDSFRPSAGWTWAGDWFVCPEKTLLHDMDAGHLSFVEEVFENQ 957

Query: 926  SRYPGGDWKPAEDTYTDANGDKAASPSELTCPPGWEWEDDAWSYDINRAVDEKGWEYGIT 985
            +R PGG W    D YTD NG+K     ++ CP GW+WED+ WS D+NRAVDE+GWEY IT
Sbjct: 958  TRLPGGQWIYMSDNYTDVNGEKVLPKDDIECPLGWKWEDEEWSTDLNRAVDEQGWEYSIT 1017

Query: 986  IPPDHKPKSWVAAEKMYHTHRRRRLVRKRKKDLTQTASSTARAMEELQDQEGWEYASLIG 1045
            IPP+ KPK WV AEKMY+THRRRR VR R++DL+Q  +       E +  EGWEYASL G
Sbjct: 1018 IPPERKPKHWVPAEKMYYTHRRRRWVRLRRRDLSQMEALKRHRQAEAEG-EGWEYASLFG 1076

Query: 1046 WKFHWKQRSSDTFRRRRWRRKMAPSETHGAAAIFKLEGALGADTTEDGDEKSLEKQKHSA 1105
            WKFH + R +D FRRRRWRR+M P E  G AA+F LEGALG       D+KS E     +
Sbjct: 1077 WKFHLEYRKTDAFRRRRWRRRMEPLEKTGPAAVFALEGALGGVM----DDKS-EDSMSVS 1131

Query: 1106 TTVFGANTPIVSCNFDRVYIYHLRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTEII 1165
            T  FG N P +SC FD    YHLRCY+YQAR+L A+DKDSFSDPYA + FLH+S+ T ++
Sbjct: 1132 TLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVV 1191

Query: 1166 HSTLNPTWDQTIIFDEVEIYGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVVKL 1225
             +TLNPTWDQT+IF E+EI+GEP TV + PP +++EL+D+D  G DEF+GR I  P    
Sbjct: 1192 KNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQP---- 1247

Query: 1226 NSEMDITPKLLWHPVMNGDKACGDVLVTAELILRGK---------------------DGS 1264
               ++  P+L W P+  G +  G++L + ELI R K                     + +
Sbjct: 1248 --SLERMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDT 1305

Query: 1265 NLPILPPQRAPNLYMVPQGIRPVVQLTAIEILAWGLRNMKNFQMASITSPSLVVECGGER 1324
            +LP  PPQR  N+YMVPQ I+P +Q TAIEILAWGLRNMK++Q+A+I+SPSLVVECGG+ 
Sbjct: 1306 DLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQT 1365

Query: 1325 VESVVIKNLKKTPNFPSSVLFMKVFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTIERL 1384
            V+S VI+NL+K PNF    LFM+V LP+EELY PP+ +KVID+RQFGR+PVVGQCTI  L
Sbjct: 1366 VQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSL 1425

Query: 1385 DRFRCDPYAGKEDIVPQ---LKASLLSAPPCRDIVIEMEDTKPLLASKLTEKEEEIVDWW 1441
            + F CDPY+  E   PQ      SLLS  P  D++I+++D +PL+      +EEE +DWW
Sbjct: 1426 ESFLCDPYSA-ESPSPQGGPDDVSLLS--PGEDVLIDIDDKEPLIPI----QEEEFIDWW 1478

Query: 1442 SKFYASSGEHEKCGQYIQKGYSKLKIYNCELENVAEFEGLTDFSDTFKLYRGKS-DENED 1500
            SKF+AS GE EKCG Y++K +  LK+Y+ +LENV  FEGL+DF +TFKLYRGK+ +E ED
Sbjct: 1479 SKFFASIGEREKCGSYLEKDFDTLKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEETED 1538

Query: 1501 PSVVGEFKGSFRIYPLPDDPSVPAPPRQFRELPDSVPQECTVRIYIVRGLELQPQDNNGL 1560
            PSV+GEFKG F+IYPLP+DP++P PPRQF +L    PQEC VRIYIVR   LQP+D NG 
Sbjct: 1539 PSVIGEFKGLFKIYPLPEDPAIPMPPRQFHQLAAQGPQECLVRIYIVRAFGLQPKDPNGK 1598

Query: 1561 CDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLPQEKDLKISVYDYDTFTRDEK 1620
            CDPYIKI++GKK + D+D+YIP TL PVFG+M+EL+C LP EKDLKI++YDYD  ++DEK
Sbjct: 1599 CDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEK 1658

Query: 1621 VGETIIDLENRFLSRFGSHCGIPEEYCVSGVNTWRDQLRPTQLLQNVARFKGFPQPILSE 1680
            +GET++DLENR LS+FG+ CG+P+ YCVSG N WRDQLRP+QLL    +      P+   
Sbjct: 1659 IGETVVDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRT 1718

Query: 1681 DGSRIRYGGRDYSLDEFEANKILHQHLGAPEERLALHILRTQGLVPEHVETRTLHSTFQP 1740
            D  R+ +  ++YS++E EA +I + HLG  EERLALH+L+ QGLVPEHVE+R L+S  QP
Sbjct: 1719 D--RVMFQDKEYSIEEIEAGRIPNPHLGPVEERLALHVLQQQGLVPEHVESRPLYSPLQP 1776

Query: 1741 NISQGKLQMWVDVFPKSLGPPGPPFNITPRKAKKYYLRVIIWNTKDVILDEKSITGEEMS 1800
            +I QGKLQMWVD+FPK+LG PGPPFNITPR+A++++LR IIWNT+DVILD+ S+TGE+MS
Sbjct: 1777 DIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWNTRDVILDDLSLTGEKMS 1836

Query: 1801 DIYVKGWIPGNEENKQKTDVHYRSLDGEGNFNWRFVFPFDYLPAEQLCIVAKKEHFWSID 1860
            DIYVKGW+ G EE+KQKTDVHYRSL GEGNFNWRF+FPFDYLPAEQ+C +AKK+ FW +D
Sbjct: 1837 DIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWRLD 1896

Query: 1861 QTEFRIPPRLIIQIWDNDKFSLDDYLGFLELDLRHTIIPAKSPEKCRLDMIPDLKAMNPL 1920
            +TE +IP R++ QIWDNDKFS DD+LG L+LDL     PAK+ +KC LD + D  A +P 
Sbjct: 1897 KTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTAKKCSLDQLDD--AFHP- 1953

Query: 1921 KAKTASLFEQKSMKGWWPCYAEKDGARVMAGKVEMTLEILNEKEADERPAGKGRDEPNMN 1980
                 SLFEQK++KGWWPC AE+   +++AGK+EMTLEI+ E E +ERPAG+GRDEPNMN
Sbjct: 1954 -EWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNMN 2012

Query: 1981 PKLDLPNRPETSFLWFTNPCKTMKFIVWRRFKWVIIGLLFLLILLLFVAVLLYSLPNYLS 2040
            PKL+ P RP+TSFLWFT+P KTMKFI+WRRF+W II  + L ILLLF+A+ +Y+ PNY +
Sbjct: 2013 PKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYAA 2072

Query: 2041 MKIVKP 2046
            MK+VKP
Sbjct: 2073 MKLVKP 2078


>gi|195976779 dysferlin isoform 1 [Homo sapiens]
          Length = 2119

 Score = 2377 bits (6159), Expect = 0.0
 Identities = 1181/2144 (55%), Positives = 1521/2144 (70%), Gaps = 125/2144 (5%)

Query: 1    MLRVIVESASNIPKTKFGK-PDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPL 59
            ML  ++  ASN+P  K  +  DP+ S+ F+  KK+TK + N +NPVWNE  E+DL+GIPL
Sbjct: 1    MLCCLLVRASNLPSAKKDRRSDPVASLTFRGVKKRTKVIKNSVNPVWNEGFEWDLKGIPL 60

Query: 60   DFSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKGQDTGATID 119
            D  S L ++VKD ET+G+N+ +G A V L+++    S S  +    LL+ K Q TGA++ 
Sbjct: 61   DQGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNA-PLLDTKKQPTGASLV 119

Query: 120  LVIGYDP-----PSAPHPNDLS-GPSVPGM-----GGDGEEDE----------------- 151
            L + Y P     P  P P  L   P++P +     GG    +                  
Sbjct: 120  LQVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVAGGGQSRAETWSLLSDSTMDTRYSGKK 179

Query: 152  --------GDEDRLDNAVRGPGPK-------GPVGTVSEAQLA----------RRLTKVK 186
                    G+ED  D  + G   +       GP    +  +L           +R     
Sbjct: 180  WPAPTDTGGEEDTEDQGLTGDEAEPFLDQSGGPGAPTTPRKLPSRPPPHYPGIKRKRSAP 239

Query: 187  NSRRMLSNKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNNPFFDELFF 246
             SR++LS+KPQDFQIRV+VIEGRQL G NI+PVVKV   GQT RTRI +GN+P F+E  F
Sbjct: 240  TSRKLLSDKPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKGNSPLFNETLF 299

Query: 247  YNVNMTPSELMDEIISIRVYNSHSLRADCLMGEFKIDVGFVYDEPGHAVMRKWLLLNDPE 306
            +N+  +P EL DE I I V +S SLR D L+GEF++DVG +Y EP HA +RKWLLL+DP+
Sbjct: 300  FNLFDSPGELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPD 359

Query: 307  DTSSGSKGYMKVSMFVLGTGDEPPPERRDRDNDSDDVESNLLLPAGIALRWVTFLLKIYR 366
            D S+G++GY+K S+ VLG GDE P ER+D   D +D+ESNLL P G+ALR   F LK++R
Sbjct: 360  DFSAGARGYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALRGAHFCLKVFR 419

Query: 367  AEDIPQMDDAFSQTVKEIFGGNADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVVN 426
            AED+PQMDDA    VK+IFG  ++KKNLVDPFVEVSFAGK +C+ I+EK ANP+WNQ + 
Sbjct: 420  AEDLPQMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNIT 479

Query: 427  LQIKFPSVCEKIKLTIYDWDRLTKNDVVGTTYLHLSKIAASGGEVEVNTGETEVGFVPTF 486
            L   FPS+CEK+++ I DWDRLT ND+V TTYL +SKI+A GGE+EV   +  +GF+PTF
Sbjct: 480  LPAMFPSMCEKMRIRIIDWDRLTHNDIVATTYLSMSKISAPGGEIEV---DDYLGFLPTF 536

Query: 487  GPCYLNLYGSPREYTGFPDPYDELNTGKGEGVAYRGRILVELATFLEKTPPDKKLEPISN 546
            GPCY+NLYGSPRE+TGFPDPY ELNTGKGEGVAYRGR+L+ L T L +   ++K+E +  
Sbjct: 537  GPCYINLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVE-HSEQKVEDLPA 595

Query: 547  DDLLVVEKYQRRRKYSLSAVFHSATMLQDVGEAIQFEVSIGNYGNKFDTTCKPLASTTQY 606
            DD+L VEKY RRRKYSL A F+SATMLQDV +AIQFEVSIGNYGNKFD TC PLASTTQY
Sbjct: 596  DDILRVEKYLRRRKYSLFAAFYSATMLQDVDDAIQFEVSIGNYGNKFDMTCLPLASTTQY 655

Query: 607  SRAVFDGNYYYYLPWAHTKPVVTLTSYWEDISHRLDAVNTLLAMAERLQTNIEALKSGIQ 666
            SRAVFDG +YYYLPW + KPVV L+SYWEDISHR++  N LL +A+RL+  +E +   ++
Sbjct: 656  SRAVFDGCHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLGIADRLEAGLEQVHLALK 715

Query: 667  GKIPANQLAELWLKLIDEVIEDTRYTLPLTEGKANVTVLDTQIRKLRSRSLSQIHEAAVR 726
             +     +  L  +L DE+I      L       + T LD  + +LR+  LSQI EAA+ 
Sbjct: 716  AQCSTEDVDSLVAQLTDELIAGCSQPLGDIHETPSATHLDQYLYQLRTHHLSQITEAALA 775

Query: 727  MRSEATDVKSTLAEIEDWLDKLMQLTEEPQNSMPDIIIWMIRGEKRLAYARIPAHQVLYS 786
            ++   +++ + L + EDWL +L  L EEPQNS+PDI+IWM++G+KR+AY R+PAHQVL+S
Sbjct: 776  LKLGHSELPAALEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFS 835

Query: 787  TSGENASGKYCGKTQTIFLKYPQEKNNGPKVPVELRVNIWLGLSAVEKKFNSFAEGTFTV 846
              G N  GK CGK QTIFLKYP EK  G ++PV++RV +W GLS  EK+FN FAEG  +V
Sbjct: 836  RRGANYCGKNCGKLQTIFLKYPMEKVPGARMPVQIRVKLWFGLSVDEKEFNQFAEGKLSV 895

Query: 847  FAEMYENQA--LMFGKWGTSGLVGRHKFSDVTGKIKLKREFFLPPKGWEWEGEWIVDPER 904
            FAE YEN+    + G WGT+GL    KFSDVTGKIKL ++ F P  GW W G+W V PE+
Sbjct: 896  FAETYENETKLALVGNWGTTGLT-YPKFSDVTGKIKLPKDSFRPSAGWTWAGDWFVCPEK 954

Query: 905  SLLTEADAGHTEFTDEVYQNESRYPGGDWKPAEDTYTDANGDKAASPSELTCPPGWEWED 964
            +LL + DAGH  F +EV++N++R PGG W    D YTD NG+K     ++ CP GW+WED
Sbjct: 955  TLLHDMDAGHLSFVEEVFENQTRLPGGQWIYMSDNYTDVNGEKVLPKDDIECPLGWKWED 1014

Query: 965  DAWSYDINRAVDEKGWEYGITIPPDHKPKSWVAAEKMYHTHRRRRLVRKRKKDLTQTASS 1024
            + WS D+NRAVDE+GWEY ITIPP+ KPK WV AEKMY+THRRRR VR R++DL+Q  + 
Sbjct: 1015 EEWSTDLNRAVDEQGWEYSITIPPERKPKHWVPAEKMYYTHRRRRWVRLRRRDLSQMEAL 1074

Query: 1025 TARAMEELQDQEGWEYASLIGWKFHWKQRSSDTFRRRRWRRKMAPSETHGAAAIFKLEGA 1084
                  E +  EGWEYASL GWKFH + R +D FRRRRWRR+M P E  G AA+F LEGA
Sbjct: 1075 KRHRQAEAEG-EGWEYASLFGWKFHLEYRKTDAFRRRRWRRRMEPLEKTGPAAVFALEGA 1133

Query: 1085 LGADTTEDGDEKSLEKQKHSATTVFGANTPIVSCNFDRVYIYHLRCYVYQARNLLALDKD 1144
            LG       D+KS E     +T  FG N P +SC FD    YHLRCY+YQAR+L A+DKD
Sbjct: 1134 LGGVM----DDKS-EDSMSVSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMDKD 1188

Query: 1145 SFSDPYAHICFLHRSKTTEIIHSTLNPTWDQTIIFDEVEIYGEPQTVLQNPPKVIMELFD 1204
            SFSDPYA + FLH+S+ T ++ +TLNPTWDQT+IF E+EI+GEP TV + PP +++EL+D
Sbjct: 1189 SFSDPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYD 1248

Query: 1205 NDQVGKDEFLGRSIFSPVVKLNSEMDITPKLLWHPVMNGDKACGDVLVTAELILRGK--- 1261
            +D  G DEF+GR I  P       ++  P+L W P+  G +  G++L + ELI R K   
Sbjct: 1249 HDTYGADEFMGRCICQP------SLERMPRLAWFPLTRGSQPSGELLASFELIQREKPAI 1302

Query: 1262 ------------------DGSNLPILPPQRAPNLYMVPQGIRPVVQLTAIEILAWGLRNM 1303
                              + ++LP  PPQR  N+YMVPQ I+P +Q TAIEILAWGLRNM
Sbjct: 1303 HHIPGFEVQETSRILDESEDTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNM 1362

Query: 1304 KNFQMASITSPSLVVECGGERVESVVIKNLKKTPNFPSSVLFMKVFLPKEELYMPPLVIK 1363
            K++Q+A+I+SPSLVVECGG+ V+S VI+NL+K PNF    LFM+V LP+EELY PP+ +K
Sbjct: 1363 KSYQLANISSPSLVVECGGQTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVK 1422

Query: 1364 VIDHRQFGRKPVVGQCTIERLDRFRCDPYAGKEDIVPQ---LKASLLSAPPCRDIVIEME 1420
            VID+RQFGR+PVVGQCTI  L+ F CDPY+  E   PQ      SLLS  P  D++I+++
Sbjct: 1423 VIDNRQFGRRPVVGQCTIRSLESFLCDPYSA-ESPSPQGGPDDVSLLS--PGEDVLIDID 1479

Query: 1421 DTKPLLASKLTE-----------------KEEEIVDWWSKFYASSGEHEKCGQYIQKGYS 1463
            D +PL+  +L +                  EEE +DWWSKF+AS GE EKCG Y++K + 
Sbjct: 1480 DKEPLIPIQLADGLSSLAPTNTASPPSSPHEEEFIDWWSKFFASIGEREKCGSYLEKDFD 1539

Query: 1464 KLKIYNCELENVAEFEGLTDFSDTFKLYRGKS-DENEDPSVVGEFKGSFRIYPLPDDPSV 1522
             LK+Y+ +LENV  FEGL+DF +TFKLYRGK+ +E EDPSV+GEFKG F+IYPLP+DP++
Sbjct: 1540 TLKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEETEDPSVIGEFKGLFKIYPLPEDPAI 1599

Query: 1523 PAPPRQFRELPDSVPQECTVRIYIVRGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIP 1582
            P PPRQF +L    PQEC VRIYIVR   LQP+D NG CDPYIKI++GKK + D+D+YIP
Sbjct: 1600 PMPPRQFHQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIP 1659

Query: 1583 NTLNPVFGRMYELSCYLPQEKDLKISVYDYDTFTRDEKVGETIIDLENRFLSRFGSHCGI 1642
             TL PVFG+M+EL+C LP EKDLKI++YDYD  ++DEK+GET++DLENR LS+FG+ CG+
Sbjct: 1660 CTLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGL 1719

Query: 1643 PEEYCVSGVNTWRDQLRPTQLLQNVARFKGFPQPILSEDGSRIRYGGRDYSLDEFEANKI 1702
            P+ YCVSG N WRDQLRP+QLL    +      P+   D  R+ +  ++YS++E EA +I
Sbjct: 1720 PQTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTD--RVMFQDKEYSIEEIEAGRI 1777

Query: 1703 LHQHLGAPEERLALHILRTQGLVPEHVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPG 1762
             + HLG  EERLALH+L+ QGLVPEHVE+R L+S  QP+I QGKLQMWVD+FPK+LG PG
Sbjct: 1778 PNPHLGPVEERLALHVLQQQGLVPEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPG 1837

Query: 1763 PPFNITPRKAKKYYLRVIIWNTKDVILDEKSITGEEMSDIYVKGWIPGNEENKQKTDVHY 1822
            PPFNITPR+A++++LR IIWNT+DVILD+ S+TGE+MSDIYVKGW+ G EE+KQKTDVHY
Sbjct: 1838 PPFNITPRRARRFFLRCIIWNTRDVILDDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHY 1897

Query: 1823 RSLDGEGNFNWRFVFPFDYLPAEQLCIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSL 1882
            RSL GEGNFNWRF+FPFDYLPAEQ+C +AKK+ FW +D+TE +IP R++ QIWDNDKFS 
Sbjct: 1898 RSLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSF 1957

Query: 1883 DDYLGFLELDLRHTIIPAKSPEKCRLDMIPDLKAMNPLKAKTASLFEQKSMKGWWPCYAE 1942
            DD+LG L+LDL     PAK+ +KC LD + D  A +P      SLFEQK++KGWWPC AE
Sbjct: 1958 DDFLGSLQLDLNRMPKPAKTAKKCSLDQLDD--AFHP--EWFVSLFEQKTVKGWWPCVAE 2013

Query: 1943 KDGARVMAGKVEMTLEILNEKEADERPAGKGRDEPNMNPKLDLPNRPETSFLWFTNPCKT 2002
            +   +++AGK+EMTLEI+ E E +ERPAG+GRDEPNMNPKL+ P RP+TSFLWFT+P KT
Sbjct: 2014 EGEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKT 2073

Query: 2003 MKFIVWRRFKWVIIGLLFLLILLLFVAVLLYSLPNYLSMKIVKP 2046
            MKFI+WRRF+W II  + L ILLLF+A+ +Y+ PNY +MK+VKP
Sbjct: 2074 MKFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMKLVKP 2117


>gi|195976762 dysferlin isoform 13 [Homo sapiens]
          Length = 2097

 Score = 2374 bits (6153), Expect = 0.0
 Identities = 1178/2126 (55%), Positives = 1513/2126 (71%), Gaps = 111/2126 (5%)

Query: 1    MLRVIVESASNIPKTKFGKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLD 60
            MLRV +  A N+        D   S +F   KK+TK + N +NPVWNE  E+DL+GIPLD
Sbjct: 1    MLRVFILYAENVHTPDTDISDAYCSAVFAGVKKRTKVIKNSVNPVWNEGFEWDLKGIPLD 60

Query: 61   FSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKGQDTGATIDL 120
              S L ++VKD ET+G+N+ +G A V L+++    S S  +    LL+ K Q TGA++ L
Sbjct: 61   QGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNA-PLLDTKKQPTGASLVL 119

Query: 121  VIGYDP-----PSAPHPNDLS-GPSVPGM-----GGDGEEDE------------------ 151
             + Y P     P  P P  L   P++P +     GG    +                   
Sbjct: 120  QVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVAGGGQSRAETWSLLSDSTMDTRYSGKKW 179

Query: 152  -------GDEDRLDNAVRGPGPK-------GPVGTVSEAQLA----------RRLTKVKN 187
                   G+ED  D  + G   +       GP    +  +L           +R      
Sbjct: 180  PAPTDTGGEEDTEDQGLTGDEAEPFLDQSGGPGAPTTPRKLPSRPPPHYPGIKRKRSAPT 239

Query: 188  SRRMLSNKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNNPFFDELFFY 247
            SR++LS+KPQDFQIRV+VIEGRQL G NI+PVVKV   GQT RTRI +GN+P F+E  F+
Sbjct: 240  SRKLLSDKPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKGNSPLFNETLFF 299

Query: 248  NVNMTPSELMDEIISIRVYNSHSLRADCLMGEFKIDVGFVYDEPGHAVMRKWLLLNDPED 307
            N+  +P EL DE I I V +S SLR D L+GEF++DVG +Y EP HA +RKWLLL+DP+D
Sbjct: 300  NLFDSPGELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDD 359

Query: 308  TSSGSKGYMKVSMFVLGTGDEPPPERRDRDNDSDDVESNLLLPAGIALRWVTFLLKIYRA 367
             S+G++GY+K S+ VLG GDE P ER+D   D +D+ESNLL P G+ALR   F LK++RA
Sbjct: 360  FSAGARGYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALRGAHFCLKVFRA 419

Query: 368  EDIPQMDDAFSQTVKEIFGGNADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVVNL 427
            ED+PQMDDA    VK+IFG  ++KKNLVDPFVEVSFAGK +C+ I+EK ANP+WNQ + L
Sbjct: 420  EDLPQMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITL 479

Query: 428  QIKFPSVCEKIKLTIYDWDRLTKNDVVGTTYLHLSKIAASGGEVEVNTGETEVGFVPTFG 487
               FPS+CEK+++ I DWDRLT ND+V TTYL +SKI+A GGE+EV   +  +GF+PTFG
Sbjct: 480  PAMFPSMCEKMRIRIIDWDRLTHNDIVATTYLSMSKISAPGGEIEV---DDYLGFLPTFG 536

Query: 488  PCYLNLYGSPREYTGFPDPYDELNTGKGEGVAYRGRILVELATFLEKTPPDKKLEPISND 547
            PCY+NLYGSPRE+TGFPDPY ELNTGKGEGVAYRGR+L+ L T L +   ++K+E +  D
Sbjct: 537  PCYINLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVE-HSEQKVEDLPAD 595

Query: 548  DLLVVEKYQRRRKYSLSAVFHSATMLQDVGEAIQFEVSIGNYGNKFDTTCKPLASTTQYS 607
            D+L VEKY RRRKYSL A F+SATMLQDV +AIQFEVSIGNYGNKFD TC PLASTTQYS
Sbjct: 596  DILRVEKYLRRRKYSLFAAFYSATMLQDVDDAIQFEVSIGNYGNKFDMTCLPLASTTQYS 655

Query: 608  RAVFDGNYYYYLPWAHTKPVVTLTSYWEDISHRLDAVNTLLAMAERLQTNIEALKSGIQG 667
            RAVFDG +YYYLPW + KPVV L+SYWEDISHR++  N LL +A+RL+  +E +   ++ 
Sbjct: 656  RAVFDGCHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLGIADRLEAGLEQVHLALKA 715

Query: 668  KIPANQLAELWLKLIDEVIEDTRYTLPLTEGKANVTVLDTQIRKLRSRSLSQIHEAAVRM 727
            +     +  L  +L DE+I      L       + T LD  + +LR+  LSQI EAA+ +
Sbjct: 716  QCSTEDVDSLVAQLTDELIAGCSQPLGDIHETPSATHLDQYLYQLRTHHLSQITEAALAL 775

Query: 728  RSEATDVKSTLAEIEDWLDKLMQLTEEPQNSMPDIIIWMIRGEKRLAYARIPAHQVLYST 787
            +   +++ + L + EDWL +L  L EEPQNS+PDI+IWM++G+KR+AY R+PAHQVL+S 
Sbjct: 776  KLGHSELPAALEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSR 835

Query: 788  SGENASGKYCGKTQTIFLKYPQEKNNGPKVPVELRVNIWLGLSAVEKKFNSFAEGTFTVF 847
             G N  GK CGK QTIFLKYP EK  G ++PV++RV +W GLS  EK+FN FAEG  +VF
Sbjct: 836  RGANYCGKNCGKLQTIFLKYPMEKVPGARMPVQIRVKLWFGLSVDEKEFNQFAEGKLSVF 895

Query: 848  AEMYENQA--LMFGKWGTSGLVGRHKFSDVTGKIKLKREFFLPPKGWEWEGEWIVDPERS 905
            AE YEN+    + G WGT+GL    KFSDVTGKIKL ++ F P  GW W G+W V PE++
Sbjct: 896  AETYENETKLALVGNWGTTGLT-YPKFSDVTGKIKLPKDSFRPSAGWTWAGDWFVCPEKT 954

Query: 906  LLTEADAGHTEFTDEVYQNESRYPGGDWKPAEDTYTDANGDKAASPSELTCPPGWEWEDD 965
            LL + DAGH  F +EV++N++R PGG W    D YTD NG+K     ++ CP GW+WED+
Sbjct: 955  LLHDMDAGHLSFVEEVFENQTRLPGGQWIYMSDNYTDVNGEKVLPKDDIECPLGWKWEDE 1014

Query: 966  AWSYDINRAVDEKGWEYGITIPPDHKPKSWVAAEKMYHTHRRRRLVRKRKKDLTQTASST 1025
             WS D+NRAVDE+GWEY ITIPP+ KPK WV AEKMY+THRRRR VR R++DL+Q  +  
Sbjct: 1015 EWSTDLNRAVDEQGWEYSITIPPERKPKHWVPAEKMYYTHRRRRWVRLRRRDLSQMEALK 1074

Query: 1026 ARAMEELQDQEGWEYASLIGWKFHWKQRSSDTFRRRRWRRKMAPSETHGAAAIFKLEGAL 1085
                 E +  EGWEYASL GWKFH + R +D FRRRRWRR+M P E  G AA+F LEGAL
Sbjct: 1075 RHRQAEAEG-EGWEYASLFGWKFHLEYRKTDAFRRRRWRRRMEPLEKTGPAAVFALEGAL 1133

Query: 1086 GADTTEDGDEKSLEKQKHSATTVFGANTPIVSCNFDRVYIYHLRCYVYQARNLLALDKDS 1145
            G       D+KS E     +T  FG N P +SC FD    YHLRCY+YQAR+L A+DKDS
Sbjct: 1134 GGVM----DDKS-EDSMSVSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMDKDS 1188

Query: 1146 FSDPYAHICFLHRSKTTEIIHSTLNPTWDQTIIFDEVEIYGEPQTVLQNPPKVIMELFDN 1205
            FSDPYA + FLH+S+ T ++ +TLNPTWDQT+IF E+EI+GEP TV + PP +++EL+D+
Sbjct: 1189 FSDPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYDH 1248

Query: 1206 DQVGKDEFLGRSIFSPVVKLNSEMDITPKLLWHPVMNGDKACGDVLVTAELILRGK---- 1261
            D  G DEF+GR I  P       ++  P+L W P+  G +  G++L + ELI R K    
Sbjct: 1249 DTYGADEFMGRCICQP------SLERMPRLAWFPLTRGSQPSGELLASFELIQREKPAIH 1302

Query: 1262 -----------------DGSNLPILPPQRAPNLYMVPQGIRPVVQLTAIEILAWGLRNMK 1304
                             + ++LP  PPQR  N+YMVPQ I+P +Q TAIEILAWGLRNMK
Sbjct: 1303 HIPGFEVQETSRILDESEDTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMK 1362

Query: 1305 NFQMASITSPSLVVECGGERVESVVIKNLKKTPNFPSSVLFMKVFLPKEELYMPPLVIKV 1364
            ++Q+A+I+SPSLVVECGG+ V+S VI+NL+K PNF    LFM+V LP+EELY PP+ +KV
Sbjct: 1363 SYQLANISSPSLVVECGGQTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKV 1422

Query: 1365 IDHRQFGRKPVVGQCTIERLDRFRCDPYAGKEDIVPQ---LKASLLSAPPCRDIVIEMED 1421
            ID+RQFGR+PVVGQCTI  L+ F CDPY+  E   PQ      SLLS  P  D++I+++D
Sbjct: 1423 IDNRQFGRRPVVGQCTIRSLESFLCDPYSA-ESPSPQGGPDDVSLLS--PGEDVLIDIDD 1479

Query: 1422 TKPLLASKLTEKEEEIVDWWSKFYASSGEHEKCGQYIQKGYSKLKIYNCELENVAEFEGL 1481
             +PL+      +EEE +DWWSKF+AS GE EKCG Y++K +  LK+Y+ +LENV  FEGL
Sbjct: 1480 KEPLIPI----QEEEFIDWWSKFFASIGEREKCGSYLEKDFDTLKVYDTQLENVEAFEGL 1535

Query: 1482 TDFSDTFKLYRGKS-DENEDPSVVGEFKGSFRIYPLPDDPSVPAPPRQFRELPDSVPQEC 1540
            +DF +TFKLYRGK+ +E EDPSV+GEFKG F+IYPLP+DP++P PPRQF +L    PQEC
Sbjct: 1536 SDFCNTFKLYRGKTQEETEDPSVIGEFKGLFKIYPLPEDPAIPMPPRQFHQLAAQGPQEC 1595

Query: 1541 TVRIYIVRGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLP 1600
             VRIYIVR   LQP+D NG CDPYIKI++GKK + D+D+YIP TL PVFG+M+EL+C LP
Sbjct: 1596 LVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLP 1655

Query: 1601 QEKDLKISVYDYDTFTRDEKVGETIIDLENRFLSRFGSHCGIPEEYCVSGVNTWRDQLRP 1660
             EKDLKI++YDYD  ++DEK+GET++DLENR LS+FG+ CG+P+ YCVSG N WRDQLRP
Sbjct: 1656 LEKDLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRP 1715

Query: 1661 TQLLQNVARFKGFPQPILSEDGSRIRYGGRDYSLDEFEANKILHQHLGAPEERLALHILR 1720
            +QLL    +      P+   D  R+ +  ++YS++E EA +I + HLG  EERLALH+L+
Sbjct: 1716 SQLLHLFCQQHRVKAPVYRTD--RVMFQDKEYSIEEIEAGRIPNPHLGPVEERLALHVLQ 1773

Query: 1721 TQGLVPEHVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGPPFNITPRKAKKYYLRVI 1780
             QGLVPEHVE+R L+S  QP+I QGKLQMWVD+FPK+LG PGPPFNITPR+A++++LR I
Sbjct: 1774 QQGLVPEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCI 1833

Query: 1781 IWNTKDVILDEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYRSLDGEGNFNWRFVFPFD 1840
            IWNT+DVILD+ S+TGE+MSDIYVKGW+ G EE+KQKTDVHYRSL GEGNFNWRF+FPFD
Sbjct: 1834 IWNTRDVILDDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFD 1893

Query: 1841 YLPAEQLCIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSLDDYLGFLELDLRHTIIPA 1900
            YLPAEQ+C +AKK+ FW +D+TE +IP R++ QIWDNDKFS DD+LG L+LDL     PA
Sbjct: 1894 YLPAEQVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPA 1953

Query: 1901 KSPEKCRLDMIPDLKAMNPLKAKTASLFEQKSMKGWWPCYAEKDGARVMAGKVEMTLEIL 1960
            K+ +KC LD + D  A +P      SLFEQK++KGWWPC AE+   +++AGK+EMTLEI+
Sbjct: 1954 KTAKKCSLDQLDD--AFHP--EWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEMTLEIV 2009

Query: 1961 NEKEADERPAGKGRDEPNMNPKLDLPNRPETSFLWFTNPCKTMKFIVWRRFKWVIIGLLF 2020
             E E +ERPAG+GRDEPNMNPKL+ P RP+TSFLWFT+P KTMKFI+WRRF+W II  + 
Sbjct: 2010 AESEHEERPAGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFII 2069

Query: 2021 LLILLLFVAVLLYSLPNYLSMKIVKP 2046
            L ILLLF+A+ +Y+ PNY +MK+VKP
Sbjct: 2070 LFILLLFLAIFIYAFPNYAAMKLVKP 2095


>gi|195976766 dysferlin isoform 7 [Homo sapiens]
          Length = 2112

 Score = 2374 bits (6152), Expect = 0.0
 Identities = 1179/2138 (55%), Positives = 1518/2138 (71%), Gaps = 120/2138 (5%)

Query: 1    MLRVIVESASNIPKTKFGK-PDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPL 59
            ML  ++  ASN+P  K  +  DP+ S+ F+  KK+TK + N +NPVWNE  E+DL+GIPL
Sbjct: 1    MLCCLLVRASNLPSAKKDRRSDPVASLTFRGVKKRTKVIKNSVNPVWNEGFEWDLKGIPL 60

Query: 60   DFSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKGQDTGATID 119
            D  S L ++VKD ET+G+N+ +G A V L+++    S S  +    LL+ K Q TGA++ 
Sbjct: 61   DQGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNA-PLLDTKKQPTGASLV 119

Query: 120  LVIGYDP-----PSAPHPNDLS-GPSVPGM-----GGDGEEDE----------------- 151
            L + Y P     P  P P  L   P++P +     GG    +                  
Sbjct: 120  LQVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVAGGGQSRAETWSLLSDSTMDTRYSGKK 179

Query: 152  --------GDEDRLDNAVRGPGPK-------GPVGTVSEAQLA----------RRLTKVK 186
                    G+ED  D  + G   +       GP    +  +L           +R     
Sbjct: 180  WPAPTDTGGEEDTEDQGLTGDEAEPFLDQSGGPGAPTTPRKLPSRPPPHYPGIKRKRSAP 239

Query: 187  NSRRMLSNKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNNPFFDELFF 246
             SR++LS+KPQDFQIRV+VIEGRQL G NI+PVVKV   GQT RTRI +GN+P F+E  F
Sbjct: 240  TSRKLLSDKPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKGNSPLFNETLF 299

Query: 247  YNVNMTPSELMDEIISIRVYNSHSLRADCLMGEFKIDVGFVYDEPGHAVMRKWLLLNDPE 306
            +N+  +P EL DE I I V +S SLR D L+GEF++DVG +Y EP HA +RKWLLL+DP+
Sbjct: 300  FNLFDSPGELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPD 359

Query: 307  DTSSGSKGYMKVSMFVLGTGDEPPPERRDRDNDSDDVESNLLLPAGIALRWVTFLLKIYR 366
            D S+G++GY+K S+ VLG GDE P ER+D   D +D+ESNLL P G+ALR   F LK++R
Sbjct: 360  DFSAGARGYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALRGAHFCLKVFR 419

Query: 367  AEDIPQMDDAFSQTVKEIFGGNADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVVN 426
            AED+PQMDDA    VK+IFG  ++KKNLVDPFVEVSFAGK +C+ I+EK ANP+WNQ + 
Sbjct: 420  AEDLPQMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNIT 479

Query: 427  LQIKFPSVCEKIKLTIYDWDRLTKNDVVGTTYLHLSKIAASGGEVEVNTG---------- 476
            L   FPS+CEK+++ I DWDRLT ND+V TTYL +SKI+A GGE+E              
Sbjct: 480  LPAMFPSMCEKMRIRIIDWDRLTHNDIVATTYLSMSKISAPGGEIEEEPAGAVKPSKASD 539

Query: 477  -ETEVGFVPTFGPCYLNLYGSPREYTGFPDPYDELNTGKGEGVAYRGRILVELATFLEKT 535
             +  +GF+PTFGPCY+NLYGSPRE+TGFPDPY ELNTGKGEGVAYRGR+L+ L T L + 
Sbjct: 540  LDDYLGFLPTFGPCYINLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVE- 598

Query: 536  PPDKKLEPISNDDLLVVEKYQRRRKYSLSAVFHSATMLQDVGEAIQFEVSIGNYGNKFDT 595
              ++K+E +  DD+L VEKY RRRKYSL A F+SATMLQDV +AIQFEVSIGNYGNKFD 
Sbjct: 599  HSEQKVEDLPADDILRVEKYLRRRKYSLFAAFYSATMLQDVDDAIQFEVSIGNYGNKFDM 658

Query: 596  TCKPLASTTQYSRAVFDGNYYYYLPWAHTKPVVTLTSYWEDISHRLDAVNTLLAMAERLQ 655
            TC PLASTTQYSRAVFDG +YYYLPW + KPVV L+SYWEDISHR++  N LL +A+RL+
Sbjct: 659  TCLPLASTTQYSRAVFDGCHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLGIADRLE 718

Query: 656  TNIEALKSGIQGKIPANQLAELWLKLIDEVIEDTRYTLPLTEGKANVTVLDTQIRKLRSR 715
              +E +   ++ +     +  L  +L DE+I      L       + T LD  + +LR+ 
Sbjct: 719  AGLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQPLGDIHETPSATHLDQYLYQLRTH 778

Query: 716  SLSQIHEAAVRMRSEATDVKSTLAEIEDWLDKLMQLTEEPQNSMPDIIIWMIRGEKRLAY 775
             LSQI EAA+ ++   +++ + L + EDWL +L  L EEPQNS+PDI+IWM++G+KR+AY
Sbjct: 779  HLSQITEAALALKLGHSELPAALEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAY 838

Query: 776  ARIPAHQVLYSTSGENASGKYCGKTQTIFLKYPQEKNNGPKVPVELRVNIWLGLSAVEKK 835
             R+PAHQVL+S  G N  GK CGK QTIFLKYP EK  G ++PV++RV +W GLS  EK+
Sbjct: 839  QRVPAHQVLFSRRGANYCGKNCGKLQTIFLKYPMEKVPGARMPVQIRVKLWFGLSVDEKE 898

Query: 836  FNSFAEGTFTVFAEMYENQA--LMFGKWGTSGLVGRHKFSDVTGKIKLKREFFLPPKGWE 893
            FN FAEG  +VFAE YEN+    + G WGT+GL    KFSDVTGKIKL ++ F P  GW 
Sbjct: 899  FNQFAEGKLSVFAETYENETKLALVGNWGTTGLT-YPKFSDVTGKIKLPKDSFRPSAGWT 957

Query: 894  WEGEWIVDPERSLLTEADAGHTEFTDEVYQNESRYPGGDWKPAEDTYTDANGDKAASPSE 953
            W G+W V PE++LL + DAGH  F +EV++N++R PGG W    D YTD NG+K     +
Sbjct: 958  WAGDWFVCPEKTLLHDMDAGHLSFVEEVFENQTRLPGGQWIYMSDNYTDVNGEKVLPKDD 1017

Query: 954  LTCPPGWEWEDDAWSYDINRAVDEKGWEYGITIPPDHKPKSWVAAEKMYHTHRRRRLVRK 1013
            + CP GW+WED+ WS D+NRAVDE+GWEY ITIPP+ KPK WV AEKMY+THRRRR VR 
Sbjct: 1018 IECPLGWKWEDEEWSTDLNRAVDEQGWEYSITIPPERKPKHWVPAEKMYYTHRRRRWVRL 1077

Query: 1014 RKKDLTQTASSTARAMEELQDQEGWEYASLIGWKFHWKQRSSDTFRRRRWRRKMAPSETH 1073
            R++DL+Q  +       E +  EGWEYASL GWKFH + R +D FRRRRWRR+M P E  
Sbjct: 1078 RRRDLSQMEALKRHRQAEAEG-EGWEYASLFGWKFHLEYRKTDAFRRRRWRRRMEPLEKT 1136

Query: 1074 GAAAIFKLEGALGADTTEDGDEKSLEKQKHSATTVFGANTPIVSCNFDRVYIYHLRCYVY 1133
            G AA+F LEGALG       D+KS E     +T  FG N P +SC FD    YHLRCY+Y
Sbjct: 1137 GPAAVFALEGALGGVM----DDKS-EDSMSVSTLSFGVNRPTISCIFDYGNRYHLRCYMY 1191

Query: 1134 QARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTWDQTIIFDEVEIYGEPQTVLQ 1193
            QAR+L A+DKDSFSDPYA + FLH+S+ T ++ +TLNPTWDQT+IF E+EI+GEP TV +
Sbjct: 1192 QARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEIEIFGEPATVAE 1251

Query: 1194 NPPKVIMELFDNDQVGKDEFLGRSIFSPVVKLNSEMDITPKLLWHPVMNGDKACGDVLVT 1253
             PP +++EL+D+D  G DEF+GR I  P       ++  P+L W P+  G +  G++L +
Sbjct: 1252 QPPSIVVELYDHDTYGADEFMGRCICQP------SLERMPRLAWFPLTRGSQPSGELLAS 1305

Query: 1254 AELILRGK---------------------DGSNLPILPPQRAPNLYMVPQGIRPVVQLTA 1292
             ELI R K                     + ++LP  PPQR  N+YMVPQ I+P +Q TA
Sbjct: 1306 FELIQREKPAIHHIPGFEVQETSRILDESEDTDLPYPPPQREANIYMVPQNIKPALQRTA 1365

Query: 1293 IEILAWGLRNMKNFQMASITSPSLVVECGGERVESVVIKNLKKTPNFPSSVLFMKVFLPK 1352
            IEILAWGLRNMK++Q+A+I+SPSLVVECGG+ V+S VI+NL+K PNF    LFM+V LP+
Sbjct: 1366 IEILAWGLRNMKSYQLANISSPSLVVECGGQTVQSCVIRNLRKNPNFDICTLFMEVMLPR 1425

Query: 1353 EELYMPPLVIKVIDHRQFGRKPVVGQCTIERLDRFRCDPYAGKEDIVPQ---LKASLLSA 1409
            EELY PP+ +KVID+RQFGR+PVVGQCTI  L+ F CDPY+  E   PQ      SLLS 
Sbjct: 1426 EELYCPPITVKVIDNRQFGRRPVVGQCTIRSLESFLCDPYSA-ESPSPQGGPDDVSLLS- 1483

Query: 1410 PPCRDIVIEMEDTKPLLASKLTEKEEEIVDWWSKFYASSGEHEKCGQYIQKGYSKLKIYN 1469
             P  D++I+++D +PL+      +EEE +DWWSKF+AS GE EKCG Y++K +  LK+Y+
Sbjct: 1484 -PGEDVLIDIDDKEPLIPI----QEEEFIDWWSKFFASIGEREKCGSYLEKDFDTLKVYD 1538

Query: 1470 CELENVAEFEGLTDFSDTFKLYRGKS-DENEDPSVVGEFKGSFRIYPLPDDPSVPAPPRQ 1528
             +LENV  FEGL+DF +TFKLYRGK+ +E EDPSV+GEFKG F+IYPLP+DP++P PPRQ
Sbjct: 1539 TQLENVEAFEGLSDFCNTFKLYRGKTQEETEDPSVIGEFKGLFKIYPLPEDPAIPMPPRQ 1598

Query: 1529 FRELPDSVPQECTVRIYIVRGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPV 1588
            F +L    PQEC VRIYIVR   LQP+D NG CDPYIKI++GKK + D+D+YIP TL PV
Sbjct: 1599 FHQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPV 1658

Query: 1589 FGRMYELSCYLPQEKDLKISVYDYDTFTRDEKVGETIIDLENRFLSRFGSHCGIPEEYCV 1648
            FG+M+EL+C LP EKDLKI++YDYD  ++DEK+GET++DLENR LS+FG+ CG+P+ YCV
Sbjct: 1659 FGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCV 1718

Query: 1649 SGVNTWRDQLRPTQLLQNVARFKGFPQPILSEDGSRIRYGGRDYSLDEFEANKILHQHLG 1708
            SG N WRDQLRP+QLL    +      P+   D  R+ +  ++YS++E EA +I + HLG
Sbjct: 1719 SGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTD--RVMFQDKEYSIEEIEAGRIPNPHLG 1776

Query: 1709 APEERLALHILRTQGLVPEHVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGPPFNIT 1768
              EERLALH+L+ QGLVPEHVE+R L+S  QP+I QGKLQMWVD+FPK+LG PGPPFNIT
Sbjct: 1777 PVEERLALHVLQQQGLVPEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPFNIT 1836

Query: 1769 PRKAKKYYLRVIIWNTKDVILDEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYRSLDGE 1828
            PR+A++++LR IIWNT+DVILD+ S+TGE+MSDIYVKGW+ G EE+KQKTDVHYRSL GE
Sbjct: 1837 PRRARRFFLRCIIWNTRDVILDDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRSLGGE 1896

Query: 1829 GNFNWRFVFPFDYLPAEQLCIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSLDDYLGF 1888
            GNFNWRF+FPFDYLPAEQ+C +AKK+ FW +D+TE +IP R++ QIWDNDKFS DD+LG 
Sbjct: 1897 GNFNWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDDFLGS 1956

Query: 1889 LELDLRHTIIPAKSPEKCRLDMIPDLKAMNPLKAKTASLFEQKSMKGWWPCYAEKDGARV 1948
            L+LDL     PAK+ +KC LD + D  A +P      SLFEQK++KGWWPC AE+   ++
Sbjct: 1957 LQLDLNRMPKPAKTAKKCSLDQLDD--AFHP--EWFVSLFEQKTVKGWWPCVAEEGEKKI 2012

Query: 1949 MAGKVEMTLEILNEKEADERPAGKGRDEPNMNPKLDLPNRPETSFLWFTNPCKTMKFIVW 2008
            +AGK+EMTLEI+ E E +ERPAG+GRDEPNMNPKL+ P RP+TSFLWFT+P KTMKFI+W
Sbjct: 2013 LAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFILW 2072

Query: 2009 RRFKWVIIGLLFLLILLLFVAVLLYSLPNYLSMKIVKP 2046
            RRF+W II  + L ILLLF+A+ +Y+ PNY +MK+VKP
Sbjct: 2073 RRFRWAIILFIILFILLLFLAIFIYAFPNYAAMKLVKP 2110


>gi|195976758 dysferlin isoform 11 [Homo sapiens]
          Length = 2101

 Score = 2374 bits (6152), Expect = 0.0
 Identities = 1178/2123 (55%), Positives = 1510/2123 (71%), Gaps = 101/2123 (4%)

Query: 1    MLRVIVESASNIPKTKFGKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLD 60
            MLRV +  A N+        D   S +F   KK+TK + N +NPVWNE  E+DL+GIPLD
Sbjct: 1    MLRVFILYAENVHTPDTDISDAYCSAVFAGVKKRTKVIKNSVNPVWNEGFEWDLKGIPLD 60

Query: 61   FSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKGQDTGATIDL 120
              S L ++VKD ET+G+N+ +G A V L+++    S S  +    LL+ K Q TGA++ L
Sbjct: 61   QGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNA-PLLDTKKQPTGASLVL 119

Query: 121  VIGYDP-----PSAPHPNDLS-GPSVPGMG----GDGEEDEGDEDRLDNAVR-------G 163
             + Y P     P  P P  L   P++P +       GEED  D+    +          G
Sbjct: 120  QVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVADTGGEEDTEDQGLTGDEAEPFLDQSGG 179

Query: 164  PGP-----KGPVGTVSEAQLARRLTKVKNSRRMLSNKPQDFQIRVRVIEGRQLSGNNIRP 218
            PG      K P          +R      SR++LS+KPQDFQIRV+VIEGRQL G NI+P
Sbjct: 180  PGAPTTPRKLPSRPPPHYPGIKRKRSAPTSRKLLSDKPQDFQIRVQVIEGRQLPGVNIKP 239

Query: 219  VVKVHVCGQTHRTRIKRGNNPFFDELFFYNVNMTPSELMDEIISIRVYNSHSLRADCLMG 278
            VVKV   GQT RTRI +GN+P F+E  F+N+  +P EL DE I I V +S SLR D L+G
Sbjct: 240  VVKVTAAGQTKRTRIHKGNSPLFNETLFFNLFDSPGELFDEPIFITVVDSRSLRTDALLG 299

Query: 279  EFKIDVGFVYDEPGHAVMRKWLLLNDPEDTSSGSKGYMKVSMFVLGTGDEPPPERRDRDN 338
            EF++DVG +Y EP HA +RKWLLL+DP+D S+G++GY+K S+ VLG GDE P ER+D   
Sbjct: 300  EFRMDVGTIYREPRHAYLRKWLLLSDPDDFSAGARGYLKTSLCVLGPGDEAPLERKDPSE 359

Query: 339  DSDDVESNLLLPAGIALRWVTFLLKIYRAEDIPQMDDAFSQTVKEIFGGNADKKNLVDPF 398
            D +D+ESNLL P G+ALR   F LK++RAED+PQMDDA    VK+IFG  ++KKNLVDPF
Sbjct: 360  DKEDIESNLLRPTGVALRGAHFCLKVFRAEDLPQMDDAVMDNVKQIFGFESNKKNLVDPF 419

Query: 399  VEVSFAGKKVCTNIIEKNANPEWNQVVNLQIKFPSVCEKIKLTIYDWDRLTKNDVVGTTY 458
            VEVSFAGK +C+ I+EK ANP+WNQ + L   FPS+CEK+++ I DWDRLT ND+V TTY
Sbjct: 420  VEVSFAGKMLCSKILEKTANPQWNQNITLPAMFPSMCEKMRIRIIDWDRLTHNDIVATTY 479

Query: 459  LHLSKIAASGGEVEVNTG-----------ETEVGFVPTFGPCYLNLYGSPREYTGFPDPY 507
            L +SKI+A GGE+E               +  +GF+PTFGPCY+NLYGSPRE+TGFPDPY
Sbjct: 480  LSMSKISAPGGEIEEEPAGAVKPSKASDLDDYLGFLPTFGPCYINLYGSPREFTGFPDPY 539

Query: 508  DELNTGKGEGVAYRGRILVELATFLEKTPPDKKLEPISNDDLLVVEKYQRRRKYSLSAVF 567
             ELNTGKGEGVAYRGR+L+ L T L +   ++K+E +  DD+L VEKY RRRKYSL A F
Sbjct: 540  TELNTGKGEGVAYRGRLLLSLETKLVE-HSEQKVEDLPADDILRVEKYLRRRKYSLFAAF 598

Query: 568  HSATMLQDVGEAIQFEVSIGNYGNKFDTTCKPLASTTQYSRAVFDGNYYYYLPWAHTKPV 627
            +SATMLQDV +AIQFEVSIGNYGNKFD TC PLASTTQYSRAVFDG +YYYLPW + KPV
Sbjct: 599  YSATMLQDVDDAIQFEVSIGNYGNKFDMTCLPLASTTQYSRAVFDGCHYYYLPWGNVKPV 658

Query: 628  VTLTSYWEDISHRLDAVNTLLAMAERLQTNIEALKSGIQGKIPANQLAELWLKLIDEVIE 687
            V L+SYWEDISHR++  N LL +A+RL+  +E +   ++ +     +  L  +L DE+I 
Sbjct: 659  VVLSSYWEDISHRIETQNQLLGIADRLEAGLEQVHLALKAQCSTEDVDSLVAQLTDELIA 718

Query: 688  DTRYTLPLTEGKANVTVLDTQIRKLRSRSLSQIHEAAVRMRSEATDVKSTLAEIEDWLDK 747
                 L       + T LD  + +LR+  LSQI EAA+ ++   +++ + L + EDWL +
Sbjct: 719  GCSQPLGDIHETPSATHLDQYLYQLRTHHLSQITEAALALKLGHSELPAALEQAEDWLLR 778

Query: 748  LMQLTEEPQNSMPDIIIWMIRGEKRLAYARIPAHQVLYSTSGENASGKYCGKTQTIFLKY 807
            L  L EEPQNS+PDI+IWM++G+KR+AY R+PAHQVL+S  G N  GK CGK QTIFLKY
Sbjct: 779  LRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSRRGANYCGKNCGKLQTIFLKY 838

Query: 808  PQEKNNGPKVPVELRVNIWLGLSAVEKKFNSFAEGTFTVFAEMYENQA--LMFGKWGTSG 865
            P EK  G ++PV++RV +W GLS  EK+FN FAEG  +VFAE YEN+    + G WGT+G
Sbjct: 839  PMEKVPGARMPVQIRVKLWFGLSVDEKEFNQFAEGKLSVFAETYENETKLALVGNWGTTG 898

Query: 866  LVGRHKFSDVTGKIKLKREFFLPPKGWEWEGEWIVDPERSLLTEADAGHTEFTDEVYQNE 925
            L    KFSDVTGKIKL ++ F P  GW W G+W V PE++LL + DAGH  F +EV++N+
Sbjct: 899  LT-YPKFSDVTGKIKLPKDSFRPSAGWTWAGDWFVCPEKTLLHDMDAGHLSFVEEVFENQ 957

Query: 926  SRYPGGDWKPAEDTYTDANGDKAASPSELTCPPGWEWEDDAWSYDINRAVDEKGWEYGIT 985
            +R PGG W    D YTD NG+K     ++ CP GW+WED+ WS D+NRAVDE+GWEY IT
Sbjct: 958  TRLPGGQWIYMSDNYTDVNGEKVLPKDDIECPLGWKWEDEEWSTDLNRAVDEQGWEYSIT 1017

Query: 986  IPPDHKPKSWVAAEKMYHTHRRRRLVRKRKKDLTQTASSTARAMEELQDQEGWEYASLIG 1045
            IPP+ KPK WV AEKMY+THRRRR VR R++DL+Q  +       E +  EGWEYASL G
Sbjct: 1018 IPPERKPKHWVPAEKMYYTHRRRRWVRLRRRDLSQMEALKRHRQAEAEG-EGWEYASLFG 1076

Query: 1046 WKFHWKQRSSDTFRRRRWRRKMAPSETHGAAAIFKLEGALGADTTEDGDEKSLEKQKHSA 1105
            WKFH + R +D FRRRRWRR+M P E  G AA+F LEGALG       D+KS E     +
Sbjct: 1077 WKFHLEYRKTDAFRRRRWRRRMEPLEKTGPAAVFALEGALGGVM----DDKS-EDSMSVS 1131

Query: 1106 TTVFGANTPIVSCNFDRVYIYHLRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTEII 1165
            T  FG N P +SC FD    YHLRCY+YQAR+L A+DKDSFSDPYA + FLH+S+ T ++
Sbjct: 1132 TLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMDKDSFSDPYAIVSFLHQSQKTVVV 1191

Query: 1166 HSTLNPTWDQTIIFDEVEIYGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVVKL 1225
             +TLNPTWDQT+IF E+EI+GEP TV + PP +++EL+D+D  G DEF+GR I  P    
Sbjct: 1192 KNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYDHDTYGADEFMGRCICQP---- 1247

Query: 1226 NSEMDITPKLLWHPVMNGDKACGDVLVTAELILRGK---------------------DGS 1264
               ++  P+L W P+  G +  G++L + ELI R K                     + +
Sbjct: 1248 --SLERMPRLAWFPLTRGSQPSGELLASFELIQREKPAIHHIPGFEVQETSRILDESEDT 1305

Query: 1265 NLPILPPQRAPNLYMVPQGIRPVVQLTAIEILAWGLRNMKNFQMASITSPSLVVECGGER 1324
            +LP  PPQR  N+YMVPQ I+P +Q TAIEILAWGLRNMK++Q+A+I+SPSLVVECGG+ 
Sbjct: 1306 DLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMKSYQLANISSPSLVVECGGQT 1365

Query: 1325 VESVVIKNLKKTPNFPSSVLFMKVFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTIERL 1384
            V+S VI+NL+K PNF    LFM+V LP+EELY PP+ +KVID+RQFGR+PVVGQCTI  L
Sbjct: 1366 VQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKVIDNRQFGRRPVVGQCTIRSL 1425

Query: 1385 DRFRCDPYAGKEDIVPQ---LKASLLSAPPCRDIVIEMEDTKPLLASKLTE--------- 1432
            + F CDPY+  E   PQ      SLLS  P  D++I+++D +PL+  +L +         
Sbjct: 1426 ESFLCDPYSA-ESPSPQGGPDDVSLLS--PGEDVLIDIDDKEPLIPIQLADGLSSLAPTN 1482

Query: 1433 --------KEEEIVDWWSKFYASSGEHEKCGQYIQKGYSKLKIYNCELENVAEFEGLTDF 1484
                     EEE +DWWSKF+AS GE EKCG Y++K +  LK+Y+ +LENV  FEGL+DF
Sbjct: 1483 TASPPSSPHEEEFIDWWSKFFASIGEREKCGSYLEKDFDTLKVYDTQLENVEAFEGLSDF 1542

Query: 1485 SDTFKLYRGKS-DENEDPSVVGEFKGSFRIYPLPDDPSVPAPPRQFRELPDSVPQECTVR 1543
             +TFKLYRGK+ +E EDPSV+GEFKG F+IYPLP+DP++P PPRQF +L    PQEC VR
Sbjct: 1543 CNTFKLYRGKTQEETEDPSVIGEFKGLFKIYPLPEDPAIPMPPRQFHQLAAQGPQECLVR 1602

Query: 1544 IYIVRGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLPQEK 1603
            IYIVR   LQP+D NG CDPYIKI++GKK + D+D+YIP TL PVFG+M+EL+C LP EK
Sbjct: 1603 IYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVFGKMFELTCTLPLEK 1662

Query: 1604 DLKISVYDYDTFTRDEKVGETIIDLENRFLSRFGSHCGIPEEYCVSGVNTWRDQLRPTQL 1663
            DLKI++YDYD  ++DEK+GET++DLENR LS+FG+ CG+P+ YCVSG N WRDQLRP+QL
Sbjct: 1663 DLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVSGPNQWRDQLRPSQL 1722

Query: 1664 LQNVARFKGFPQPILSEDGSRIRYGGRDYSLDEFEANKILHQHLGAPEERLALHILRTQG 1723
            L    +      P+   D  R+ +  ++YS++E EA +I + HLG  EERLALH+L+ QG
Sbjct: 1723 LHLFCQQHRVKAPVYRTD--RVMFQDKEYSIEEIEAGRIPNPHLGPVEERLALHVLQQQG 1780

Query: 1724 LVPEHVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGPPFNITPRKAKKYYLRVIIWN 1783
            LVPEHVE+R L+S  QP+I QGKLQMWVD+FPK+LG PGPPFNITPR+A++++LR IIWN
Sbjct: 1781 LVPEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPFNITPRRARRFFLRCIIWN 1840

Query: 1784 TKDVILDEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYRSLDGEGNFNWRFVFPFDYLP 1843
            T+DVILD+ S+TGE+MSDIYVKGW+ G EE+KQKTDVHYRSL GEGNFNWRF+FPFDYLP
Sbjct: 1841 TRDVILDDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEGNFNWRFIFPFDYLP 1900

Query: 1844 AEQLCIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSLDDYLGFLELDLRHTIIPAKSP 1903
            AEQ+C +AKK+ FW +D+TE +IP R++ QIWDNDKFS DD+LG L+LDL     PAK+ 
Sbjct: 1901 AEQVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDDFLGSLQLDLNRMPKPAKTA 1960

Query: 1904 EKCRLDMIPDLKAMNPLKAKTASLFEQKSMKGWWPCYAEKDGARVMAGKVEMTLEILNEK 1963
            +KC LD + D  A +P      SLFEQK++KGWWPC AE+   +++AGK+EMTLEI+ E 
Sbjct: 1961 KKCSLDQLDD--AFHP--EWFVSLFEQKTVKGWWPCVAEEGEKKILAGKLEMTLEIVAES 2016

Query: 1964 EADERPAGKGRDEPNMNPKLDLPNRPETSFLWFTNPCKTMKFIVWRRFKWVIIGLLFLLI 2023
            E +ERPAG+GRDEPNMNPKL+ P RP+TSFLWFT+P KTMKFI+WRRF+W II  + L I
Sbjct: 2017 EHEERPAGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFILWRRFRWAIILFIILFI 2076

Query: 2024 LLLFVAVLLYSLPNYLSMKIVKP 2046
            LLLF+A+ +Y+ PNY +MK+VKP
Sbjct: 2077 LLLFLAIFIYAFPNYAAMKLVKP 2099


>gi|195976764 dysferlin isoform 14 [Homo sapiens]
          Length = 2118

 Score = 2371 bits (6145), Expect = 0.0
 Identities = 1179/2143 (55%), Positives = 1515/2143 (70%), Gaps = 124/2143 (5%)

Query: 1    MLRVIVESASNIPKTKFGKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLD 60
            MLRV +  A N+        D   S +F   KK+TK + N +NPVWNE  E+DL+GIPLD
Sbjct: 1    MLRVFILYAENVHTPDTDISDAYCSAVFAGVKKRTKVIKNSVNPVWNEGFEWDLKGIPLD 60

Query: 61   FSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKGQDTGATIDL 120
              S L ++VKD ET+G+N+ +G A V L+++    S S  +    LL+ K Q TGA++ L
Sbjct: 61   QGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNA-PLLDTKKQPTGASLVL 119

Query: 121  VIGYDP-----PSAPHPNDLS-GPSVPGM-----GGDGEEDE------------------ 151
             + Y P     P  P P  L   P++P +     GG    +                   
Sbjct: 120  QVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVAGGGQSRAETWSLLSDSTMDTRYSGKKW 179

Query: 152  -------GDEDRLDNAVRGPGPK-------GPVGTVSEAQLA----------RRLTKVKN 187
                   G+ED  D  + G   +       GP    +  +L           +R      
Sbjct: 180  PAPTDTGGEEDTEDQGLTGDEAEPFLDQSGGPGAPTTPRKLPSRPPPHYPGIKRKRSAPT 239

Query: 188  SRRMLSNKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNNPFFDELFFY 247
            SR++LS+KPQDFQIRV+VIEGRQL G NI+PVVKV   GQT RTRI +GN+P F+E  F+
Sbjct: 240  SRKLLSDKPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKGNSPLFNETLFF 299

Query: 248  NVNMTPSELMDEIISIRVYNSHSLRADCLMGEFKIDVGFVYDEPGHAVMRKWLLLNDPED 307
            N+  +P EL DE I I V +S SLR D L+GEF++DVG +Y EP HA +RKWLLL+DP+D
Sbjct: 300  NLFDSPGELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDD 359

Query: 308  TSSGSKGYMKVSMFVLGTGDEPPPERRDRDNDSDDVESNLLLPAGIALRWVTFLLKIYRA 367
             S+G++GY+K S+ VLG GDE P ER+D   D +D+ESNLL P G+ALR   F LK++RA
Sbjct: 360  FSAGARGYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALRGAHFCLKVFRA 419

Query: 368  EDIPQMDDAFSQTVKEIFGGNADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVVNL 427
            ED+PQMDDA    VK+IFG  ++KKNLVDPFVEVSFAGK +C+ I+EK ANP+WNQ + L
Sbjct: 420  EDLPQMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITL 479

Query: 428  QIKFPSVCEKIKLTIYDWDRLTKNDVVGTTYLHLSKIAASGGEVEVNTGETEVGFVPTFG 487
               FPS+CEK+++ I DWDRLT ND+V TTYL +SKI+A GGE+EV   +  +GF+PTFG
Sbjct: 480  PAMFPSMCEKMRIRIIDWDRLTHNDIVATTYLSMSKISAPGGEIEV---DDYLGFLPTFG 536

Query: 488  PCYLNLYGSPREYTGFPDPYDELNTGKGEGVAYRGRILVELATFLEKTPPDKKLEPISND 547
            PCY+NLYGSPRE+TGFPDPY ELNTGKGEGVAYRGR+L+ L T L +   ++K+E +  D
Sbjct: 537  PCYINLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVE-HSEQKVEDLPAD 595

Query: 548  DLLVVEKYQRRRKYSLSAVFHSATMLQDVGEAIQFEVSIGNYGNKFDTTCKPLASTTQYS 607
            D+L VEKY RRRKYSL A F+SATMLQDV +AIQFEVSIGNYGNKFD TC PLASTTQYS
Sbjct: 596  DILRVEKYLRRRKYSLFAAFYSATMLQDVDDAIQFEVSIGNYGNKFDMTCLPLASTTQYS 655

Query: 608  RAVFDGNYYYYLPWAHTKPVVTLTSYWEDISHRLDAVNTLLAMAERLQTNIEALKSGIQG 667
            RAVFDG +YYYLPW + KPVV L+SYWEDISHR++  N LL +A+RL+  +E +   ++ 
Sbjct: 656  RAVFDGCHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLGIADRLEAGLEQVHLALKA 715

Query: 668  KIPANQLAELWLKLIDEVIEDTRYTLPLTEGKANVTVLDTQIRKLRSRSLSQIHEAAVRM 727
            +     +  L  +L DE+I      L       + T LD  + +LR+  LSQI EAA+ +
Sbjct: 716  QCSTEDVDSLVAQLTDELIAGCSQPLGDIHETPSATHLDQYLYQLRTHHLSQITEAALAL 775

Query: 728  RSEATDVKSTLAEIEDWLDKLMQLTEEPQNSMPDIIIWMIRGEKRLAYARIPAHQVLYST 787
            +   +++ + L + EDWL +L  L EEPQNS+PDI+IWM++G+KR+AY R+PAHQVL+S 
Sbjct: 776  KLGHSELPAALEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQRVPAHQVLFSR 835

Query: 788  SGENASGKYCGKTQTIFLKYPQEKNNGPKVPVELRVNIWLGLSAVEKKFNSFAEGTFTVF 847
             G N  GK CGK QTIFLKYP EK  G ++PV++RV +W GLS  EK+FN FAEG  +VF
Sbjct: 836  RGANYCGKNCGKLQTIFLKYPMEKVPGARMPVQIRVKLWFGLSVDEKEFNQFAEGKLSVF 895

Query: 848  AEMYENQA--LMFGKWGTSGLVGRHKFSDVTGKIKLKREFFLPPKGWEWEGEWIVDPERS 905
            AE YEN+    + G WGT+GL    KFSDVTGKIKL ++ F P  GW W G+W V PE++
Sbjct: 896  AETYENETKLALVGNWGTTGLT-YPKFSDVTGKIKLPKDSFRPSAGWTWAGDWFVCPEKT 954

Query: 906  LLTEADAGHTEFTDEVYQNESRYPGGDWKPAEDTYTDANGDKAASPSELTCPPGWEWEDD 965
            LL + DAGH  F +EV++N++R PGG W    D YTD NG+K     ++ CP GW+WED+
Sbjct: 955  LLHDMDAGHLSFVEEVFENQTRLPGGQWIYMSDNYTDVNGEKVLPKDDIECPLGWKWEDE 1014

Query: 966  AWSYDINRAVDEKGWEYGITIPPDHKPKSWVAAEKMYHTHRRRRLVRKRKKDLTQTASST 1025
             WS D+NRAVDE+GWEY ITIPP+ KPK WV AEKMY+THRRRR VR R++DL+Q  +  
Sbjct: 1015 EWSTDLNRAVDEQGWEYSITIPPERKPKHWVPAEKMYYTHRRRRWVRLRRRDLSQMEALK 1074

Query: 1026 ARAMEELQDQEGWEYASLIGWKFHWKQRSSDTFRRRRWRRKMAPSETHGAAAIFKLEGAL 1085
                 E +  EGWEYASL GWKFH + R +D FRRRRWRR+M P E  G AA+F LEGAL
Sbjct: 1075 RHRQAEAEG-EGWEYASLFGWKFHLEYRKTDAFRRRRWRRRMEPLEKTGPAAVFALEGAL 1133

Query: 1086 GADTTEDGDEKSLEKQKHSATTVFGANTPIVSCNFDRVYIYHLRCYVYQARNLLALDKDS 1145
            G       D+KS E     +T  FG N P +SC FD    YHLRCY+YQAR+L A+DKDS
Sbjct: 1134 GGVM----DDKS-EDSMSVSTLSFGVNRPTISCIFDYGNRYHLRCYMYQARDLAAMDKDS 1188

Query: 1146 FSDPYAHICFLHRSKTTEIIHSTLNPTWDQTIIFDEVEIYGEPQTVLQNPPKVIMELFDN 1205
            FSDPYA + FLH+S+ T ++ +TLNPTWDQT+IF E+EI+GEP TV + PP +++EL+D+
Sbjct: 1189 FSDPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEIEIFGEPATVAEQPPSIVVELYDH 1248

Query: 1206 DQVGKDEFLGRSIFSPVVKLNSEMDITPKLLWHPVMNGDKACGDVLVTAELILRGK---- 1261
            D  G DEF+GR I  P       ++  P+L W P+  G +  G++L + ELI R K    
Sbjct: 1249 DTYGADEFMGRCICQP------SLERMPRLAWFPLTRGSQPSGELLASFELIQREKPAIH 1302

Query: 1262 -----------------DGSNLPILPPQRAPNLYMVPQGIRPVVQLTAIEILAWGLRNMK 1304
                             + ++LP  PPQR  N+YMVPQ I+P +Q TAIEILAWGLRNMK
Sbjct: 1303 HIPGFEVQETSRILDESEDTDLPYPPPQREANIYMVPQNIKPALQRTAIEILAWGLRNMK 1362

Query: 1305 NFQMASITSPSLVVECGGERVESVVIKNLKKTPNFPSSVLFMKVFLPKEELYMPPLVIKV 1364
            ++Q+A+I+SPSLVVECGG+ V+S VI+NL+K PNF    LFM+V LP+EELY PP+ +KV
Sbjct: 1363 SYQLANISSPSLVVECGGQTVQSCVIRNLRKNPNFDICTLFMEVMLPREELYCPPITVKV 1422

Query: 1365 IDHRQFGRKPVVGQCTIERLDRFRCDPYAGKEDIVPQ---LKASLLSAPPCRDIVIEMED 1421
            ID+RQFGR+PVVGQCTI  L+ F CDPY+  E   PQ      SLLS  P  D++I+++D
Sbjct: 1423 IDNRQFGRRPVVGQCTIRSLESFLCDPYSA-ESPSPQGGPDDVSLLS--PGEDVLIDIDD 1479

Query: 1422 TKPLLASKLTE-----------------KEEEIVDWWSKFYASSGEHEKCGQYIQKGYSK 1464
             +PL+  +L +                  EEE +DWWSKF+AS GE EKCG Y++K +  
Sbjct: 1480 KEPLIPIQLADGLSSLAPTNTASPPSSPHEEEFIDWWSKFFASIGEREKCGSYLEKDFDT 1539

Query: 1465 LKIYNCELENVAEFEGLTDFSDTFKLYRGKS-DENEDPSVVGEFKGSFRIYPLPDDPSVP 1523
            LK+Y+ +LENV  FEGL+DF +TFKLYRGK+ +E EDPSV+GEFKG F+IYPLP+DP++P
Sbjct: 1540 LKVYDTQLENVEAFEGLSDFCNTFKLYRGKTQEETEDPSVIGEFKGLFKIYPLPEDPAIP 1599

Query: 1524 APPRQFRELPDSVPQECTVRIYIVRGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPN 1583
             PPRQF +L    PQEC VRIYIVR   LQP+D NG CDPYIKI++GKK + D+D+YIP 
Sbjct: 1600 MPPRQFHQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPC 1659

Query: 1584 TLNPVFGRMYELSCYLPQEKDLKISVYDYDTFTRDEKVGETIIDLENRFLSRFGSHCGIP 1643
            TL PVFG+M+EL+C LP EKDLKI++YDYD  ++DEK+GET++DLENR LS+FG+ CG+P
Sbjct: 1660 TLEPVFGKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLP 1719

Query: 1644 EEYCVSGVNTWRDQLRPTQLLQNVARFKGFPQPILSEDGSRIRYGGRDYSLDEFEANKIL 1703
            + YCVSG N WRDQLRP+QLL    +      P+   D  R+ +  ++YS++E EA +I 
Sbjct: 1720 QTYCVSGPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTD--RVMFQDKEYSIEEIEAGRIP 1777

Query: 1704 HQHLGAPEERLALHILRTQGLVPEHVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGP 1763
            + HLG  EERLALH+L+ QGLVPEHVE+R L+S  QP+I QGKLQMWVD+FPK+LG PGP
Sbjct: 1778 NPHLGPVEERLALHVLQQQGLVPEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGP 1837

Query: 1764 PFNITPRKAKKYYLRVIIWNTKDVILDEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYR 1823
            PFNITPR+A++++LR IIWNT+DVILD+ S+TGE+MSDIYVKGW+ G EE+KQKTDVHYR
Sbjct: 1838 PFNITPRRARRFFLRCIIWNTRDVILDDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYR 1897

Query: 1824 SLDGEGNFNWRFVFPFDYLPAEQLCIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSLD 1883
            SL GEGNFNWRF+FPFDYLPAEQ+C +AKK+ FW +D+TE +IP R++ QIWDNDKFS D
Sbjct: 1898 SLGGEGNFNWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFD 1957

Query: 1884 DYLGFLELDLRHTIIPAKSPEKCRLDMIPDLKAMNPLKAKTASLFEQKSMKGWWPCYAEK 1943
            D+LG L+LDL     PAK+ +KC LD + D  A +P      SLFEQK++KGWWPC AE+
Sbjct: 1958 DFLGSLQLDLNRMPKPAKTAKKCSLDQLDD--AFHP--EWFVSLFEQKTVKGWWPCVAEE 2013

Query: 1944 DGARVMAGKVEMTLEILNEKEADERPAGKGRDEPNMNPKLDLPNRPETSFLWFTNPCKTM 2003
               +++AGK+EMTLEI+ E E +ERPAG+GRDEPNMNPKL+ P RP+TSFLWFT+P KTM
Sbjct: 2014 GEKKILAGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTM 2073

Query: 2004 KFIVWRRFKWVIIGLLFLLILLLFVAVLLYSLPNYLSMKIVKP 2046
            KFI+WRRF+W II  + L ILLLF+A+ +Y+ PNY +MK+VKP
Sbjct: 2074 KFILWRRFRWAIILFIILFILLLFLAIFIYAFPNYAAMKLVKP 2116


>gi|195976760 dysferlin isoform 12 [Homo sapiens]
          Length = 2111

 Score = 2368 bits (6138), Expect = 0.0
 Identities = 1177/2137 (55%), Positives = 1512/2137 (70%), Gaps = 119/2137 (5%)

Query: 1    MLRVIVESASNIPKTKFGKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLD 60
            MLRV +  A N+        D   S +F   KK+TK + N +NPVWNE  E+DL+GIPLD
Sbjct: 1    MLRVFILYAENVHTPDTDISDAYCSAVFAGVKKRTKVIKNSVNPVWNEGFEWDLKGIPLD 60

Query: 61   FSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKGQDTGATIDL 120
              S L ++VKD ET+G+N+ +G A V L+++    S S  +    LL+ K Q TGA++ L
Sbjct: 61   QGSELHVVVKDHETMGRNRFLGEAKVPLREVLATPSLSASFNA-PLLDTKKQPTGASLVL 119

Query: 121  VIGYDP-----PSAPHPNDLS-GPSVPGM-----GGDGEEDE------------------ 151
             + Y P     P  P P  L   P++P +     GG    +                   
Sbjct: 120  QVSYTPLPGAVPLFPPPTPLEPSPTLPDLDVVAGGGQSRAETWSLLSDSTMDTRYSGKKW 179

Query: 152  -------GDEDRLDNAVRGPGPK-------GPVGTVSEAQLA----------RRLTKVKN 187
                   G+ED  D  + G   +       GP    +  +L           +R      
Sbjct: 180  PAPTDTGGEEDTEDQGLTGDEAEPFLDQSGGPGAPTTPRKLPSRPPPHYPGIKRKRSAPT 239

Query: 188  SRRMLSNKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNNPFFDELFFY 247
            SR++LS+KPQDFQIRV+VIEGRQL G NI+PVVKV   GQT RTRI +GN+P F+E  F+
Sbjct: 240  SRKLLSDKPQDFQIRVQVIEGRQLPGVNIKPVVKVTAAGQTKRTRIHKGNSPLFNETLFF 299

Query: 248  NVNMTPSELMDEIISIRVYNSHSLRADCLMGEFKIDVGFVYDEPGHAVMRKWLLLNDPED 307
            N+  +P EL DE I I V +S SLR D L+GEF++DVG +Y EP HA +RKWLLL+DP+D
Sbjct: 300  NLFDSPGELFDEPIFITVVDSRSLRTDALLGEFRMDVGTIYREPRHAYLRKWLLLSDPDD 359

Query: 308  TSSGSKGYMKVSMFVLGTGDEPPPERRDRDNDSDDVESNLLLPAGIALRWVTFLLKIYRA 367
             S+G++GY+K S+ VLG GDE P ER+D   D +D+ESNLL P G+ALR   F LK++RA
Sbjct: 360  FSAGARGYLKTSLCVLGPGDEAPLERKDPSEDKEDIESNLLRPTGVALRGAHFCLKVFRA 419

Query: 368  EDIPQMDDAFSQTVKEIFGGNADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVVNL 427
            ED+PQMDDA    VK+IFG  ++KKNLVDPFVEVSFAGK +C+ I+EK ANP+WNQ + L
Sbjct: 420  EDLPQMDDAVMDNVKQIFGFESNKKNLVDPFVEVSFAGKMLCSKILEKTANPQWNQNITL 479

Query: 428  QIKFPSVCEKIKLTIYDWDRLTKNDVVGTTYLHLSKIAASGGEVEVNTG----------- 476
               FPS+CEK+++ I DWDRLT ND+V TTYL +SKI+A GGE+E               
Sbjct: 480  PAMFPSMCEKMRIRIIDWDRLTHNDIVATTYLSMSKISAPGGEIEEEPAGAVKPSKASDL 539

Query: 477  ETEVGFVPTFGPCYLNLYGSPREYTGFPDPYDELNTGKGEGVAYRGRILVELATFLEKTP 536
            +  +GF+PTFGPCY+NLYGSPRE+TGFPDPY ELNTGKGEGVAYRGR+L+ L T L +  
Sbjct: 540  DDYLGFLPTFGPCYINLYGSPREFTGFPDPYTELNTGKGEGVAYRGRLLLSLETKLVE-H 598

Query: 537  PDKKLEPISNDDLLVVEKYQRRRKYSLSAVFHSATMLQDVGEAIQFEVSIGNYGNKFDTT 596
             ++K+E +  DD+L VEKY RRRKYSL A F+SATMLQDV +AIQFEVSIGNYGNKFD T
Sbjct: 599  SEQKVEDLPADDILRVEKYLRRRKYSLFAAFYSATMLQDVDDAIQFEVSIGNYGNKFDMT 658

Query: 597  CKPLASTTQYSRAVFDGNYYYYLPWAHTKPVVTLTSYWEDISHRLDAVNTLLAMAERLQT 656
            C PLASTTQYSRAVFDG +YYYLPW + KPVV L+SYWEDISHR++  N LL +A+RL+ 
Sbjct: 659  CLPLASTTQYSRAVFDGCHYYYLPWGNVKPVVVLSSYWEDISHRIETQNQLLGIADRLEA 718

Query: 657  NIEALKSGIQGKIPANQLAELWLKLIDEVIEDTRYTLPLTEGKANVTVLDTQIRKLRSRS 716
             +E +   ++ +     +  L  +L DE+I      L       + T LD  + +LR+  
Sbjct: 719  GLEQVHLALKAQCSTEDVDSLVAQLTDELIAGCSQPLGDIHETPSATHLDQYLYQLRTHH 778

Query: 717  LSQIHEAAVRMRSEATDVKSTLAEIEDWLDKLMQLTEEPQNSMPDIIIWMIRGEKRLAYA 776
            LSQI EAA+ ++   +++ + L + EDWL +L  L EEPQNS+PDI+IWM++G+KR+AY 
Sbjct: 779  LSQITEAALALKLGHSELPAALEQAEDWLLRLRALAEEPQNSLPDIVIWMLQGDKRVAYQ 838

Query: 777  RIPAHQVLYSTSGENASGKYCGKTQTIFLKYPQEKNNGPKVPVELRVNIWLGLSAVEKKF 836
            R+PAHQVL+S  G N  GK CGK QTIFLKYP EK  G ++PV++RV +W GLS  EK+F
Sbjct: 839  RVPAHQVLFSRRGANYCGKNCGKLQTIFLKYPMEKVPGARMPVQIRVKLWFGLSVDEKEF 898

Query: 837  NSFAEGTFTVFAEMYENQA--LMFGKWGTSGLVGRHKFSDVTGKIKLKREFFLPPKGWEW 894
            N FAEG  +VFAE YEN+    + G WGT+GL    KFSDVTGKIKL ++ F P  GW W
Sbjct: 899  NQFAEGKLSVFAETYENETKLALVGNWGTTGLT-YPKFSDVTGKIKLPKDSFRPSAGWTW 957

Query: 895  EGEWIVDPERSLLTEADAGHTEFTDEVYQNESRYPGGDWKPAEDTYTDANGDKAASPSEL 954
             G+W V PE++LL + DAGH  F +EV++N++R PGG W    D YTD NG+K     ++
Sbjct: 958  AGDWFVCPEKTLLHDMDAGHLSFVEEVFENQTRLPGGQWIYMSDNYTDVNGEKVLPKDDI 1017

Query: 955  TCPPGWEWEDDAWSYDINRAVDEKGWEYGITIPPDHKPKSWVAAEKMYHTHRRRRLVRKR 1014
             CP GW+WED+ WS D+NRAVDE+GWEY ITIPP+ KPK WV AEKMY+THRRRR VR R
Sbjct: 1018 ECPLGWKWEDEEWSTDLNRAVDEQGWEYSITIPPERKPKHWVPAEKMYYTHRRRRWVRLR 1077

Query: 1015 KKDLTQTASSTARAMEELQDQEGWEYASLIGWKFHWKQRSSDTFRRRRWRRKMAPSETHG 1074
            ++DL+Q  +       E +  EGWEYASL GWKFH + R +D FRRRRWRR+M P E  G
Sbjct: 1078 RRDLSQMEALKRHRQAEAEG-EGWEYASLFGWKFHLEYRKTDAFRRRRWRRRMEPLEKTG 1136

Query: 1075 AAAIFKLEGALGADTTEDGDEKSLEKQKHSATTVFGANTPIVSCNFDRVYIYHLRCYVYQ 1134
             AA+F LEGALG       D+KS E     +T  FG N P +SC FD    YHLRCY+YQ
Sbjct: 1137 PAAVFALEGALGGVM----DDKS-EDSMSVSTLSFGVNRPTISCIFDYGNRYHLRCYMYQ 1191

Query: 1135 ARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTWDQTIIFDEVEIYGEPQTVLQN 1194
            AR+L A+DKDSFSDPYA + FLH+S+ T ++ +TLNPTWDQT+IF E+EI+GEP TV + 
Sbjct: 1192 ARDLAAMDKDSFSDPYAIVSFLHQSQKTVVVKNTLNPTWDQTLIFYEIEIFGEPATVAEQ 1251

Query: 1195 PPKVIMELFDNDQVGKDEFLGRSIFSPVVKLNSEMDITPKLLWHPVMNGDKACGDVLVTA 1254
            PP +++EL+D+D  G DEF+GR I  P       ++  P+L W P+  G +  G++L + 
Sbjct: 1252 PPSIVVELYDHDTYGADEFMGRCICQP------SLERMPRLAWFPLTRGSQPSGELLASF 1305

Query: 1255 ELILRGK---------------------DGSNLPILPPQRAPNLYMVPQGIRPVVQLTAI 1293
            ELI R K                     + ++LP  PPQR  N+YMVPQ I+P +Q TAI
Sbjct: 1306 ELIQREKPAIHHIPGFEVQETSRILDESEDTDLPYPPPQREANIYMVPQNIKPALQRTAI 1365

Query: 1294 EILAWGLRNMKNFQMASITSPSLVVECGGERVESVVIKNLKKTPNFPSSVLFMKVFLPKE 1353
            EILAWGLRNMK++Q+A+I+SPSLVVECGG+ V+S VI+NL+K PNF    LFM+V LP+E
Sbjct: 1366 EILAWGLRNMKSYQLANISSPSLVVECGGQTVQSCVIRNLRKNPNFDICTLFMEVMLPRE 1425

Query: 1354 ELYMPPLVIKVIDHRQFGRKPVVGQCTIERLDRFRCDPYAGKEDIVPQ---LKASLLSAP 1410
            ELY PP+ +KVID+RQFGR+PVVGQCTI  L+ F CDPY+  E   PQ      SLLS  
Sbjct: 1426 ELYCPPITVKVIDNRQFGRRPVVGQCTIRSLESFLCDPYSA-ESPSPQGGPDDVSLLS-- 1482

Query: 1411 PCRDIVIEMEDTKPLLASKLTEKEEEIVDWWSKFYASSGEHEKCGQYIQKGYSKLKIYNC 1470
            P  D++I+++D +PL+      +EEE +DWWSKF+AS GE EKCG Y++K +  LK+Y+ 
Sbjct: 1483 PGEDVLIDIDDKEPLIPI----QEEEFIDWWSKFFASIGEREKCGSYLEKDFDTLKVYDT 1538

Query: 1471 ELENVAEFEGLTDFSDTFKLYRGKS-DENEDPSVVGEFKGSFRIYPLPDDPSVPAPPRQF 1529
            +LENV  FEGL+DF +TFKLYRGK+ +E EDPSV+GEFKG F+IYPLP+DP++P PPRQF
Sbjct: 1539 QLENVEAFEGLSDFCNTFKLYRGKTQEETEDPSVIGEFKGLFKIYPLPEDPAIPMPPRQF 1598

Query: 1530 RELPDSVPQECTVRIYIVRGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVF 1589
             +L    PQEC VRIYIVR   LQP+D NG CDPYIKI++GKK + D+D+YIP TL PVF
Sbjct: 1599 HQLAAQGPQECLVRIYIVRAFGLQPKDPNGKCDPYIKISIGKKSVSDQDNYIPCTLEPVF 1658

Query: 1590 GRMYELSCYLPQEKDLKISVYDYDTFTRDEKVGETIIDLENRFLSRFGSHCGIPEEYCVS 1649
            G+M+EL+C LP EKDLKI++YDYD  ++DEK+GET++DLENR LS+FG+ CG+P+ YCVS
Sbjct: 1659 GKMFELTCTLPLEKDLKITLYDYDLLSKDEKIGETVVDLENRLLSKFGARCGLPQTYCVS 1718

Query: 1650 GVNTWRDQLRPTQLLQNVARFKGFPQPILSEDGSRIRYGGRDYSLDEFEANKILHQHLGA 1709
            G N WRDQLRP+QLL    +      P+   D  R+ +  ++YS++E EA +I + HLG 
Sbjct: 1719 GPNQWRDQLRPSQLLHLFCQQHRVKAPVYRTD--RVMFQDKEYSIEEIEAGRIPNPHLGP 1776

Query: 1710 PEERLALHILRTQGLVPEHVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGPPFNITP 1769
             EERLALH+L+ QGLVPEHVE+R L+S  QP+I QGKLQMWVD+FPK+LG PGPPFNITP
Sbjct: 1777 VEERLALHVLQQQGLVPEHVESRPLYSPLQPDIEQGKLQMWVDLFPKALGRPGPPFNITP 1836

Query: 1770 RKAKKYYLRVIIWNTKDVILDEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYRSLDGEG 1829
            R+A++++LR IIWNT+DVILD+ S+TGE+MSDIYVKGW+ G EE+KQKTDVHYRSL GEG
Sbjct: 1837 RRARRFFLRCIIWNTRDVILDDLSLTGEKMSDIYVKGWMIGFEEHKQKTDVHYRSLGGEG 1896

Query: 1830 NFNWRFVFPFDYLPAEQLCIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSLDDYLGFL 1889
            NFNWRF+FPFDYLPAEQ+C +AKK+ FW +D+TE +IP R++ QIWDNDKFS DD+LG L
Sbjct: 1897 NFNWRFIFPFDYLPAEQVCTIAKKDAFWRLDKTESKIPARVVFQIWDNDKFSFDDFLGSL 1956

Query: 1890 ELDLRHTIIPAKSPEKCRLDMIPDLKAMNPLKAKTASLFEQKSMKGWWPCYAEKDGARVM 1949
            +LDL     PAK+ +KC LD + D  A +P      SLFEQK++KGWWPC AE+   +++
Sbjct: 1957 QLDLNRMPKPAKTAKKCSLDQLDD--AFHP--EWFVSLFEQKTVKGWWPCVAEEGEKKIL 2012

Query: 1950 AGKVEMTLEILNEKEADERPAGKGRDEPNMNPKLDLPNRPETSFLWFTNPCKTMKFIVWR 2009
            AGK+EMTLEI+ E E +ERPAG+GRDEPNMNPKL+ P RP+TSFLWFT+P KTMKFI+WR
Sbjct: 2013 AGKLEMTLEIVAESEHEERPAGQGRDEPNMNPKLEDPRRPDTSFLWFTSPYKTMKFILWR 2072

Query: 2010 RFKWVIIGLLFLLILLLFVAVLLYSLPNYLSMKIVKP 2046
            RF+W II  + L ILLLF+A+ +Y+ PNY +MK+VKP
Sbjct: 2073 RFRWAIILFIILFILLLFLAIFIYAFPNYAAMKLVKP 2109


>gi|164607133 fer-1-like 5 isoform 2 [Homo sapiens]
          Length = 2093

 Score = 1526 bits (3950), Expect = 0.0
 Identities = 850/2123 (40%), Positives = 1219/2123 (57%), Gaps = 167/2123 (7%)

Query: 1    MLRVIVESASNIPKTKFGKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLD 60
            MLR++V+SA   P      P P +S+ F+D KK+T+ V+   +PVWNE L + L   PL+
Sbjct: 1    MLRLVVQSAKIDPPLA-PLPRPCMSIDFRDIKKRTRVVEGN-DPVWNETLIWHLWNRPLE 58

Query: 61   FSSSLGIIVKDFETIGQNKLIGTATVALKDLTGDQSRSLPYKLISLLNEKGQDTGATIDL 120
              S L + ++D  +  + + IG ATV LK L    S  L  K ++LLN   + T  T+ L
Sbjct: 59   NDSFLQVTLQDMGSQKKERFIGLATVLLKPLLKQPSEVLFVKDLTLLNHSMKPTDCTVTL 118

Query: 121  VIGYDPPSAPHPNDLSGPSVPGMGGDGEEDEGDEDRLDNAVRGPGPKGPVGTVSEAQLAR 180
             + +                  M     E  G ED L    R            EA   +
Sbjct: 119  QVAH------------------MSNQDIEKTGAEDHLGITAR------------EAASQK 148

Query: 181  RLTKVKNSRRMLSNKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNNPF 240
             +     + R LS+KPQ FQ+RV+V E RQL GNNI+PVVKV + GQ H+TRIK GNNPF
Sbjct: 149  LMVPGSTAHRALSSKPQHFQVRVKVFEARQLMGNNIKPVVKVSIAGQQHQTRIKMGNNPF 208

Query: 241  FDELFFYNVNMTPSELMDEIISIRVYNSHSLRADCLMGEFKIDVGFVYDEPGHAVMRKWL 300
            F+E+FF N +  P++  DE I I+                  D+GF+Y  PGH ++RKWL
Sbjct: 209  FNEIFFQNFHEVPAKFFDETILIQT-----------------DIGFIYHSPGHTLLRKWL 251

Query: 301  LLNDPEDTSSGSKGYMKVSMFVLGTGDEPPPERRDRDNDSDDVESNLLLPAGIALRWVTF 360
             L  P +  SG  GY+KV+++ LG GD+   +++     +DD +  +   A + +     
Sbjct: 252  GLCQPNNPGSGVTGYLKVTIYALGVGDQALIDQKLLYG-TDDTDIQIFKSAVVPINMAYL 310

Query: 361  LLKIYRAEDIPQMDDAFSQTVKEIFGGNADKKNLVDPFVEVSFAGKKVCTNIIEKNANPE 420
             L IY AED+                 +  K   V+P +EV   G+K+ T++  +  NP 
Sbjct: 311  QLFIYCAEDL-----------------HLKKHQSVNPQLEVELIGEKLRTHMQTQTDNPI 353

Query: 421  WNQVVNLQIKFPSVCEKIKLTIYDWDRLTKNDVVGTTYLHLSKIAASGGEVEVN------ 474
            WNQ++  +I+ P +   IK  + D  +    D +GT  L L++I+++G E+E        
Sbjct: 354  WNQILTFRIQLPCLSSYIKFRVLDCRKKDCPDEIGTASLSLNQISSTGEEIEGKQSLEPT 413

Query: 475  --TGETEVGFVPTFGPCYLNLYGSPREYTGFPDPYDELNTGKGEGVAYRGRILVELATFL 532
              T     GF+P FGP +L L+G  +      +    +     +G+AYRGR+ +EL T +
Sbjct: 414  SYTPRVYSGFLPCFGPSFLTLHGGKKAPFRIQEEGACIPDSVRDGLAYRGRVFLELITQI 473

Query: 533  EKTPPDKKLEPISNDDLLVVEKYQRRRKYSLSAVFHSATMLQDVGEAIQFEVSIGNYGNK 592
             K+  D  ++ +S++ +  +EK+Q R+KY L  +F S TM+ +  E I FEVSIG+YGNK
Sbjct: 474  -KSYQDSTIKDLSHE-VTRIEKHQNRQKYGLCVIFLSCTMMPNFKELIHFEVSIGHYGNK 531

Query: 593  FDTTCKPLASTTQYSRAVFDGNYYYYLPWAHTKPVVTLTSYWEDISHRLDAVNTLLAMAE 652
             D   KPL S+T YS  ++DGN Y+Y+PW +TKPVV +TS WED+S R++ +N L    +
Sbjct: 532  MDLNYKPLVSSTPYSPVIYDGNIYHYVPWYNTKPVVAVTSNWEDVSFRMNCLNLLHFTRD 591

Query: 653  RLQTNIEALKSGIQGKIPANQLAELWLKLIDEVIEDTRYTLPLTEGKANVTVLDTQIRKL 712
            RL+ N++ LKS    K PA  L   W KL+ E+ ED +  LP    +   T LD +  +L
Sbjct: 592  RLKANLDTLKSTRNPKDPA--LLYQWEKLLRELAEDCKRPLPCMTYQPKATSLDRKRWQL 649

Query: 713  RSRSLSQIHEAAVRMRSEATDVKSTLAEIEDWLDKLMQLTEEPQNSMPDIIIWMIRGEKR 772
            RS  L ++ + A + +      K  +A  EDWL +L  +  EPQ  +PD++IW++  E+R
Sbjct: 650  RSLLLQELAQKAKQAKP-----KDMVATAEDWLYRLNTVLPEPQMGLPDVMIWLVAKEQR 704

Query: 773  LAYARIPAHQVLYSTSGENASGKYCGKTQTIFLKYPQEKNNGPKVPVELRVNIWLGLSAV 832
            +AYA++PAH VL+S +G   SG+ CGK QT+FL+YP+ +     +P  LRV +WLG    
Sbjct: 705  VAYAQVPAHSVLFSPAGALHSGRLCGKIQTLFLQYPEGEGQKDVLPAHLRVCMWLGNVTD 764

Query: 833  EKKFNSFAEGTFTVFAEMYENQALMFGKWGTSGLVGRHKFSDVTGKIKLKREFFLPPKGW 892
             K      +G   V+AEMYENQA    +WG  GL     FSDV G   L    F PP GW
Sbjct: 765  SKDLQLLRQGDTAVYAEMYENQAKYKDQWGQQGLYHCPNFSDVMGNKTLPMTDFQPPLGW 824

Query: 893  EWEGEWIVDPERSLLTEADAGHTEFTDEVYQNESRYPGGDWKPAEDTYTDANGDKAASPS 952
             W+  W V+P+R LL + D   ++  +EVY+N+ R   G W PA    TD NG    +  
Sbjct: 825  HWQDSWTVEPQRRLLLDIDINKSQVLEEVYENQGRDTRGAWGPAAIPNTDVNGQPMEARE 884

Query: 953  ELTCPPGWEWEDDAWSYDINRAVDEKGWEYGITIPPDHKPKSWVAAEKMYHTHRRRRLVR 1012
             + CP GW ++ D W  ++N AVD   WEYG+ IPP   P+ W   EK YH+ RRRR  R
Sbjct: 885  NVKCPQGWHFKKD-WVVELNHAVDS--WEYGVGIPPSGLPQVWSPVEKTYHSCRRRRWAR 941

Query: 1013 KRKKDLTQTASSTARAMEELQ------DQEGWEYASLIGWKFHWKQRSSDTFRRRRWRRK 1066
             R ++  +  S     +  LQ      ++EGWEY +  G KFH   +    FRRR WRR+
Sbjct: 942  VRFRNHGEL-SHEQETLSFLQLGLAKGEEEGWEYDTF-GSKFHLNPQPQSRFRRRCWRRR 999

Query: 1067 MAPSETHGAAAIFKLEGAL---GADTTEDGD--------------------------EKS 1097
            +AP++  G A IF LEG+L   G    E+GD                          +  
Sbjct: 1000 LAPNKDKGIAPIFLLEGSLACEGGSVREEGDWAWARGNRSSTQEPQGRLSWVQAMDLKYH 1059

Query: 1098 LEKQKHSATTVFGA---------------NTPIVSCNFDRVYIYHLRCYVYQARNLLALD 1142
              K++ S T  +G                N P + C F++ + Y L CY+YQARNL++  
Sbjct: 1060 AGKEEDSKTWPWGLDRQFRDPQRQDTRPPNLPFIYCTFNKPHYYQLFCYIYQARNLVSNQ 1119

Query: 1143 KDSFSDPYAHICFLHRSKTTEIIHSTLNPTWDQTIIFDEVEIYGEPQTVLQNPPKVIMEL 1202
              +F  P+  + FL+ S+ T+ + S+  PTW QT+IF  + +Y  PQ   ++PP V++EL
Sbjct: 1120 ILTFQGPFIRVVFLNHSQCTQTLRSSAGPTWAQTLIFQHLLLYENPQDTKESPPLVVLEL 1179

Query: 1203 FDNDQVGKDEFLGRSIFSPVVKLNSEMDITPKLLWHPVMNG-DKACGDVLVTAELILRGK 1261
            +  D  GK+   GRS++ P+V L+ +  I P + WHP++    K  G++L + ELIL+ +
Sbjct: 1180 WQRDFWGKESLWGRSVWPPMVWLDLQDRILPPMRWHPLVKELGKEEGEILASCELILQTE 1239

Query: 1262 D--GSNLPILPPQRAPNLYMVPQGIRPVVQLTAIEILAWGLRNMKNFQMASITSPSLVVE 1319
                  LPIL        Y +P+ I+P ++  AIEILAWGLRNMK       +SP L+VE
Sbjct: 1240 KLGEKQLPILSVPWKNGAYTLPKSIQPTIKRMAIEILAWGLRNMKK-----ASSPQLLVE 1294

Query: 1320 CGGERVESVVIKNLKKTPNFPSS--VLFMKVFLPKEELYMPPLVIKVIDHRQFGRKPVVG 1377
             G E + +  I++ +  PNFP S  VL + V +P EE Y  PLV+KV+D+  FG++ V G
Sbjct: 1295 FGEESLRTEPIRDFQTNPNFPESESVLVLTVLMPTEEAYALPLVVKVVDNWAFGQQTVTG 1354

Query: 1378 QCTIERLDRFRCDPYAGKEDIVPQLKASLLSAPPCRDIVIEMEDTKPLLASKLTEKEEEI 1437
            Q  I+ L  + CDP+A ++ + P+L    LS    +D +  +       +SK  ++ E  
Sbjct: 1355 QANIDFLQPYFCDPWA-QDYMHPKLPT--LSEKKHQDFLGYLYRKFWFKSSKAEDEYEHE 1411

Query: 1438 VDWWSKFYASSGEHEKCGQYIQKGYSKLKIYNCELENVAEFEGLTDFSDTFKLYRGKSDE 1497
            VDWWSK + ++ EH+   +Y  K Y  LK+Y CELE V  F+GL DF  TFKLY+     
Sbjct: 1412 VDWWSKLFWATDEHKSL-KYKYKDYHTLKVYECELEAVPAFQGLQDFCQTFKLYQ--EQP 1468

Query: 1498 NEDPSVVGEFKGSFRIYPLPDDPSVPAPPRQFRELPD--SVPQECTVRIYIVRGLELQPQ 1555
              D  VVGEFKG FRIYP P++P  P PP QF   P+    PQ C VR+Y+VR + LQPQ
Sbjct: 1469 KLDSPVVGEFKGLFRIYPFPENPEAPKPPLQFLVWPEREDFPQPCLVRVYMVRAINLQPQ 1528

Query: 1556 DNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLPQEKDLKISVYDYDTF 1615
            D NGLCDPY+ + LGK  + +RD Y PNTL+P+FG M+EL+C +P EKDL+I +YD+D F
Sbjct: 1529 DYNGLCDPYVILKLGKTELGNRDMYQPNTLDPIFGMMFELTCNIPLEKDLEIQLYDFDLF 1588

Query: 1616 TRDEKVGETIIDLENRFLSRFGSHCGIPEEYCVSGVNTWRDQLRPTQLLQNVARFKGFPQ 1675
            + D+K+G T+IDLENR LS FG+HCG+ + YC SG   WRDQ+ P+ LL+  A+ KG P 
Sbjct: 1589 SPDDKIGTTVIDLENRLLSGFGAHCGLSKSYCQSGPFRWRDQMPPSYLLERYAKRKGLPP 1648

Query: 1676 PILSEDGSRIRYGGRDYSLDEFEANKILHQHLGAPEERLALHILRTQGLVPEHVETRTLH 1735
            P+ S +   + Y G+ + L  FE        LG  +ERLAL++L TQGLVPEHVETRTL+
Sbjct: 1649 PLFSPEEDAVFYNGKKFKLQSFEPKTPTVHGLGPKKERLALYLLHTQGLVPEHVETRTLY 1708

Query: 1736 STFQPNISQGKLQMWVDVFPKSLGPPGPPFNITPRKAK---------KYYLRVIIWNTKD 1786
            S  QP I QGK+QMWVD+FPK LGPPGP  NI PRK K         +Y LR IIW T +
Sbjct: 1709 SHSQPGIDQGKVQMWVDIFPKKLGPPGPQVNINPRKPKRKASEHSGHRYELRCIIWKTAN 1768

Query: 1787 VILDEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYRSLDGEGNFNWRFVFPFDYLPAEQ 1846
            V L + +++ E+ SDIY+KGW+ G E++ QKTD+HY SL GE +FNWRF+F  DYL AE+
Sbjct: 1769 VDLVDDNLSREKTSDIYIKGWLYGLEKDMQKTDIHYHSLTGEADFNWRFIFTMDYLAAER 1828

Query: 1847 LCIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSLDDYLGFLELDLRHTIIPAKSPEKC 1906
             C+ ++K++ WS+D T  + P RLIIQ+WDND FS DD+LG LELDL    +PA+  ++C
Sbjct: 1829 TCVQSQKDYIWSLDATSMKFPARLIIQVWDNDIFSPDDFLGVLELDLSDMPLPARHAKQC 1888

Query: 1907 RLDMI-PDLKAMNPLKAKTASLFEQKSMKGWWPCYAEKDGARVMAGKVEMTLEILNEKEA 1965
             + M+  D K    ++ K  SLF++K++ GWWPC     G   ++GKV+M+LEIL+EKEA
Sbjct: 1889 SIRMMDADPKWPYFIQYKHFSLFKKKTVTGWWPCQVLDGGKWRLSGKVKMSLEILSEKEA 1948

Query: 1966 DERPAGKGRDEPNMNPKLDLPNRPETSFLWFTNPCKTMKFIVWRRFKWVIIGLLFLLILL 2025
              +PAG+G+ EPN  P L  P R  TSF W  +P +   +I W+R+++ +I  + + I+ 
Sbjct: 1949 LIKPAGRGQSEPNQYPTLHPPLRTNTSFTWLRSPVQNFCYIFWKRYRFKLIAFMVISIIA 2008

Query: 2026 LFVAVLLYSLPNYLSMKIVKPNV 2048
            L +   +YS P+YL+M  +KP +
Sbjct: 2009 LMLFNFIYSAPHYLAMSWIKPQL 2031


>gi|116642865 fer-1-like 5 isoform 1 [Homo sapiens]
          Length = 802

 Score =  718 bits (1853), Expect = 0.0
 Identities = 357/746 (47%), Positives = 493/746 (66%), Gaps = 11/746 (1%)

Query: 1308 MASITSPSLVVECGGERVESVVIKNLKKTPNFPSS--VLFMKVFLPKEELYMPPLVIKVI 1365
            M   +SP L+VE G E + +  I++ +  PNFP S  VL + V +P EE Y  PLV+KV+
Sbjct: 1    MKKASSPQLLVEFGEESLRTEPIRDFQTNPNFPESESVLVLTVLMPTEEAYALPLVVKVV 60

Query: 1366 DHRQFGRKPVVGQCTIERLDRFRCDPYAGKEDIVPQLKASLLSAPPCRDIVIEMEDTKPL 1425
            D+  FG++ V GQ  I+ L  + CDP+A ++ + P+L    LS    +D +  +      
Sbjct: 61   DNWAFGQQTVTGQANIDFLQPYFCDPWA-QDYMHPKLPT--LSEKKHQDFLGYLYRKFWF 117

Query: 1426 LASKLTEKEEEIVDWWSKFYASSGEHEKCGQYIQKGYSKLKIYNCELENVAEFEGLTDFS 1485
             +SK  ++ E  VDWWSK + ++ EH+   +Y  K Y  LK+Y CELE V  F+GL DF 
Sbjct: 118  KSSKAEDEYEHEVDWWSKLFWATDEHKSL-KYKYKDYHTLKVYECELEAVPAFQGLQDFC 176

Query: 1486 DTFKLYRGKSDENEDPSVVGEFKGSFRIYPLPDDPSVPAPPRQFRELPD--SVPQECTVR 1543
             TFKLY+       D  VVGEFKG FRIYP P++P  P PP QF   P+    PQ C VR
Sbjct: 177  QTFKLYQ--EQPKLDSPVVGEFKGLFRIYPFPENPEAPKPPLQFLVWPEREDFPQPCLVR 234

Query: 1544 IYIVRGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLPQEK 1603
            +Y+VR + LQPQD NGLCDPY+ + LGK  + +RD Y PNTL+P+FG M+EL+C +P EK
Sbjct: 235  VYMVRAINLQPQDYNGLCDPYVILKLGKTELGNRDMYQPNTLDPIFGMMFELTCNIPLEK 294

Query: 1604 DLKISVYDYDTFTRDEKVGETIIDLENRFLSRFGSHCGIPEEYCVSGVNTWRDQLRPTQL 1663
            DL+I +YD+D F+ D+K+G T+IDLENR LS FG+HCG+ + YC SG   WRDQ+ P+ L
Sbjct: 295  DLEIQLYDFDLFSPDDKIGTTVIDLENRLLSGFGAHCGLSKSYCQSGPFRWRDQMPPSYL 354

Query: 1664 LQNVARFKGFPQPILSEDGSRIRYGGRDYSLDEFEANKILHQHLGAPEERLALHILRTQG 1723
            L+  A+ KG P P+ S +   + Y G+ + L  FE        LG  +ERLAL++L TQG
Sbjct: 355  LERYAKRKGLPPPLFSPEEDAVFYNGKKFKLQSFEPKTPTVHGLGPKKERLALYLLHTQG 414

Query: 1724 LVPEHVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGPPFNITPRKAKKYYLRVIIWN 1783
            LVPEHVETRTL+S  QP I QGK+QMWVD+FPK LGPPGP  NI PRK K+Y LR IIW 
Sbjct: 415  LVPEHVETRTLYSHSQPGIDQGKVQMWVDIFPKKLGPPGPQVNINPRKPKRYELRCIIWK 474

Query: 1784 TKDVILDEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYRSLDGEGNFNWRFVFPFDYLP 1843
            T +V L + +++ E+ SDIY+KGW+ G E++ QKTD+HY SL GE +FNWRF+F  DYL 
Sbjct: 475  TANVDLVDDNLSREKTSDIYIKGWLYGLEKDMQKTDIHYHSLTGEADFNWRFIFTMDYLA 534

Query: 1844 AEQLCIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSLDDYLGFLELDLRHTIIPAKSP 1903
            AE+ C+ ++K++ WS+D T  + P RLIIQ+WDND FS DD+LG LELDL    +PA+  
Sbjct: 535  AERTCVQSQKDYIWSLDATSMKFPARLIIQVWDNDIFSPDDFLGVLELDLSDMPLPARHA 594

Query: 1904 EKCRLDMI-PDLKAMNPLKAKTASLFEQKSMKGWWPCYAEKDGARVMAGKVEMTLEILNE 1962
            ++C + M+  D K    ++ K  SLF++K++ GWWPC     G   ++GKV+M+LEIL+E
Sbjct: 595  KQCSIRMMDADPKWPYFIQYKHFSLFKKKTVTGWWPCQVLDGGKWRLSGKVKMSLEILSE 654

Query: 1963 KEADERPAGKGRDEPNMNPKLDLPNRPETSFLWFTNPCKTMKFIVWRRFKWVIIGLLFLL 2022
            KEA  +PAG+G+ EPN  P L  P R  TSF W  +P +   +I W+R+++ +I  + + 
Sbjct: 655  KEALIKPAGRGQSEPNQYPTLHPPLRTNTSFTWLRSPVQNFCYIFWKRYRFKLIAFMVIS 714

Query: 2023 ILLLFVAVLLYSLPNYLSMKIVKPNV 2048
            I+ L +   +YS P+YL+M  +KP +
Sbjct: 715  IIALMLFNFIYSAPHYLAMSWIKPQL 740



 Score = 33.1 bits (74), Expect = 2.9
 Identities = 54/213 (25%), Positives = 86/213 (40%), Gaps = 24/213 (11%)

Query: 368 EDIPQMDDAFSQTVKEIFGGNADKKNLVDPFVEVSFAGKKVCTN--IIEKNA-NPEWNQV 424
           ED PQ        V+ I     D   L DP+V +   GK    N  + + N  +P +  +
Sbjct: 225 EDFPQPCLVRVYMVRAINLQPQDYNGLCDPYVILKL-GKTELGNRDMYQPNTLDPIFGMM 283

Query: 425 VNLQIKFPSVCEKIKLTIYDWDRLTKNDVVGTTYLHLSKIAASGGEVEVNTGETEVGFVP 484
             L    P + + +++ +YD+D  + +D +GTT + L     SG        ++     P
Sbjct: 284 FELTCNIP-LEKDLEIQLYDFDLFSPDDKIGTTVIDLENRLLSGFGAHCGLSKSYCQSGP 342

Query: 485 -----TFGPCYLNLYGSPREYTGFPDPYDELNTGKGEGVAYRGRILVELATFLEKTPPDK 539
                   P YL    + R+  G P P   L + + + V Y G+   +L +F  KTP   
Sbjct: 343 FRWRDQMPPSYLLERYAKRK--GLPPP---LFSPEEDAVFYNGK-KFKLQSFEPKTPTVH 396

Query: 540 KLEP--------ISNDDLLVVEKYQRRRKYSLS 564
            L P        + +   LV E  + R  YS S
Sbjct: 397 GLGPKKERLALYLLHTQGLVPEHVETRTLYSHS 429


>gi|119120884 fer-1-like 6 [Homo sapiens]
          Length = 1857

 Score =  689 bits (1779), Expect = 0.0
 Identities = 393/1066 (36%), Positives = 585/1066 (54%), Gaps = 152/1066 (14%)

Query: 1110 GANTPIVSCNFDRVYIYHLRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTL 1169
            G N P  +  +   +++ LR ++YQAR L+A D +  SDP+A + FL   +TT+II  TL
Sbjct: 810  GTNHPPSNLLYQEQHVFQLRAHMYQARGLIAADSNGLSDPFAKVTFLSHCQTTKIISQTL 869

Query: 1170 NPTWDQTIIFDEVEIYGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVVKLNSEM 1229
            +PTW+Q ++F+++ ++G+ + + ++PP V++EL+D+D VGK E+LG ++ +PVVKL  + 
Sbjct: 870  SPTWNQMLLFNDLVLHGDVKELAESPPLVVVELYDSDAVGKPEYLGATVAAPVVKLADQD 929

Query: 1230 DITPKLLWHPVMNGDKACGDVLVTAELILRGKDG-SNLPILPPQRAPNLYMVPQGIRPVV 1288
               P+L +HP+  G+ + GD+L   EL+     G   LP + P     +Y VP  IRPV+
Sbjct: 930  YEPPRLCYHPIFCGNLSGGDLLAVFELLQVPPSGLQGLPPVEPPDITQIYPVPANIRPVL 989

Query: 1289 QLTAIEILAWGLRNMKNFQMASITSPSLVVECGGERVESVVIKNLKKTPNFPSSVLFMKV 1348
                +E+L WG+R MK  Q+ S+  P  ++ECGG+ V+S VI++ K  PNF       +V
Sbjct: 990  SKYRVEVLFWGVREMKKVQLLSVDRPQALIECGGQGVKSCVIQSYKNNPNFSIQADAFEV 1049

Query: 1349 FLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTIERLDRFRC------------DPYAGKE 1396
             LP+ EL  PPL I V+D R FGR  +VG  TI  L +F C            D      
Sbjct: 1050 ELPENELLHPPLSICVVDWRAFGRSTLVGTYTINYLKQFLCKLREPLAPITQVDGTQPGH 1109

Query: 1397 DIVPQLKASLLSA-------PPCRDIVIEME---------------------DTKPLLAS 1428
            DI   L A+  S        PP   I +++E                     D+ P+L  
Sbjct: 1110 DISDSLTATESSGAHSSSQDPPADHIYVDVEPPPTVVPDSAQAQPAILVDVPDSSPMLEP 1169

Query: 1429 KLT--------------------------------EKEEEIVDWWSKFYASSGEHEKCGQ 1456
            + T                                E  E ++DWWSK+YAS  + +K  +
Sbjct: 1170 EHTPVAQEPPKDGKPKDPRKPSRRSTKRRKRTIADESAENVIDWWSKYYASLKKAQKAKE 1229

Query: 1457 YIQKG---------------------------------------YSKLKIYNCELENVAE 1477
               KG                                        + L+IY+ +LE+  E
Sbjct: 1230 RNPKGKKGNTEAKPDEVVVDIEDGPKKKKDKMLKKKPKDDGIPNLAILQIYDGDLES--E 1287

Query: 1478 FEGLTDFSDTFKLYRGKSDENED----PSVVGEFKGSFRIYPLPDDPSVP--APPRQFRE 1531
            F    D+  TF+L+RGKS E++       V+G+FKGSF IY  P D S       R  + 
Sbjct: 1288 FNNFEDWVKTFELFRGKSTEDDHGLDGDRVIGKFKGSFCIYKSPQDSSSEDSGQLRIQQG 1347

Query: 1532 LPDSVPQECTVRIYIVRGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFGR 1591
            +P + P    +R+YIV    L P D +G  DPYI I LGK  I+DRD YIP  LNPVFGR
Sbjct: 1348 IPPNHPVTVLIRVYIVAAFNLSPADPDGKSDPYIVIKLGKTEIKDRDKYIPKQLNPVFGR 1407

Query: 1592 MYELSCYLPQEKDLKISVYDYDTFTRDEKVGETIIDLENRFLSRFGSHCGIPEEYCVSGV 1651
             +E+    P+E  L I +YD+D    D+ +GET IDLENRF S+  + CG+  +Y + G 
Sbjct: 1408 SFEIQATFPKESLLSILIYDHDMIGTDDLIGETKIDLENRFYSKHRAICGLQSQYEIEGY 1467

Query: 1652 NTWRDQLRPTQLLQNVARFKGFPQPILSEDGSRIRYGGRDYS----LDEFEANKILHQHL 1707
            N WRD  +PT++L  + +      P       +I+ G + +S      E + ++ +  + 
Sbjct: 1468 NAWRDTSKPTEILTKLCKDNKLDGPYFHP--GKIQIGNQVFSGKTIFTEEDTDETVESY- 1524

Query: 1708 GAPEERLALHILRTQG--------LVPEHVETRTLHSTFQPNISQGKLQMWVDVFPKSLG 1759
                E LAL +L +          LVPEH+ETR L+   +P + QG+LQMWVD+FPK + 
Sbjct: 1525 ----EHLALKVLHSWEDIPEVGCRLVPEHIETRPLYHKDKPGMEQGRLQMWVDMFPKDMP 1580

Query: 1760 PPGPPFNITPRKAKKYYLRVIIWNTKDVILDEKSI-TGEEMSDIYVKGWIPGNEENKQKT 1818
             PGPP +I+PR+ K Y LRV IWNT+DVIL++++I TG++ SDIYVKGW+ G E++KQ+T
Sbjct: 1581 QPGPPVDISPRRPKGYELRVTIWNTEDVILEDENIFTGQKSSDIYVKGWLKGLEDDKQET 1640

Query: 1819 DVHYRSLDGEGNFNWRFVFPFDYLPAEQLCIVAKKEHFWSIDQTEFRIPPRLIIQIWDND 1878
            DVHY SL GEGNFNWRF+FPF YLPAE+  ++ K+E+ +S+++ E + P  L++Q+WD +
Sbjct: 1641 DVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVITKRENIFSLEKMECKTPAVLVLQVWDFE 1700

Query: 1879 KFSLDDYLGFLELDLRHTIIPAKSPEKCRLDMIPDLKAMNPLKAKTASLFEQKSMKGWWP 1938
            + S DD+LG LE++L      AKS + C L      K  N  +    S+F+QK ++GWWP
Sbjct: 1701 RLSSDDFLGTLEMNLNSFPRAAKSAKACDL-----AKFENASEETKISIFQQKRVRGWWP 1755

Query: 1939 CYAEKDGARVMAGKVEMTLEILNEKEADERPAGKGRDEPNMNPKLDLPNRPETSFLWFTN 1998
                K+    + GKVE    ++  +EA++ P GK R EP     L  PNRP+TSF WF +
Sbjct: 1756 FSKSKE----LTGKVEAEFHLVTAEEAEKNPVGKARKEPE---PLAKPNRPDTSFSWFMS 1808

Query: 1999 PCKTMKFIVWRRFKWVIIGLLFLLILLLFVAVLLYSLPNYLSMKIV 2044
            P K + +++W+ +K  II    L+IL++F+ + +Y+LP  +S +IV
Sbjct: 1809 PFKCLYYLIWKNYKKYIIIAFILIILIIFLVLFIYTLPGAISRRIV 1854



 Score =  354 bits (909), Expect = 4e-97
 Identities = 250/782 (31%), Positives = 396/782 (50%), Gaps = 123/782 (15%)

Query: 148 EEDEGDEDRL-DNAVRGPGPKG----------PVGTVSEAQLARRLTKVKNSRRMLSNKP 196
           ++ +GD + L +      GP+G          PV + S  + ++ LTK+ +       + 
Sbjct: 25  KDSQGDTEALQEEPSHQEGPRGDLVHDDASIFPVPSASPKRRSKLLTKIHDGEV----RS 80

Query: 197 QDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRG-NNPFFDELFFYNVNMTPSE 255
           Q++QI + + E RQL G NI PVV + +  +  ++ +K G N+PF++E F ++       
Sbjct: 81  QNYQIAITITEARQLVGENIDPVVTIEIGDEKKQSTVKEGTNSPFYNEYFVFDFIGPQVH 140

Query: 256 LMDEIISIRVYNSHSLRADCLMGEFKIDVGFVYDEPGHAVMRKWLLLNDPEDTSSGSKGY 315
           L D+II I V++ H L    L+G FK+D+G VY++PGH    KW LL DP D  +G+KGY
Sbjct: 141 LFDKIIKISVFH-HKLIGSVLIGSFKVDLGTVYNQPGHQFCNKWALLTDPGDIRTGTKGY 199

Query: 316 MKVSMFVLGTGDEPPPERRDRDNDSDDVESNLLLPAGIALR--WVTFLLKIYRAEDIPQM 373
           +K  + V+G GD      +  D + + +E NLL+P G  L   W  F +++Y+AE +P+M
Sbjct: 200 LKCDISVMGKGDVLKTSPKTSDTE-EPIEKNLLIPNGFPLERPWARFYVRLYKAEGLPKM 258

Query: 374 DDAFSQTVKEIFGGNADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVVNLQIKFPS 433
           + +    V + F G  D K+LVDPFVEVSFAG+   T + +  A+P W++ V  +  FP 
Sbjct: 259 NSSIMANVTKAFVG--DSKDLVDPFVEVSFAGQMGRTTVQKNCADPVWHEQVIFKEMFPP 316

Query: 434 VCEKIKLTIYDWDRLTKNDV-VGTTYLHLSKIAASGGEVEVNTGETEVGFVPTFGPCYLN 492
           +C ++K+ +  WD  + NDV + T ++ L KI+        N  + + GF+PTFGP ++N
Sbjct: 317 LCRRVKIQV--WDEGSMNDVALATHFIDLKKIS--------NEQDGDKGFLPTFGPAWIN 366

Query: 493 LYGSPREYTGFPDPYDELNTGKGEGVAYRGRILVELATFL-------------------- 532
           LYGSPR ++   D Y E+N G GEGV++RGRILVE+A  +                    
Sbjct: 367 LYGSPRNHS-LMDDYQEMNEGFGEGVSFRGRILVEIAVEILSGRAQESKFSKALKELKLP 425

Query: 533 ---------------EKTPPDKKLEPI--SNDDLLVVEKY--------QRRRKYSLSAVF 567
                          +KT   K  +    +N   + VE +        ++  ++ L   F
Sbjct: 426 SKDKDSKSSKGKDKADKTEDGKSQQASNKTNSTEVEVESFDVPPEIVPEKNEEFLLFGAF 485

Query: 568 HSATML-QDVGE-AIQFEVSIGNYGNKFDTTCK--------------------------- 598
             ATM+ + +G+  I FEVSIGN+GN  D                               
Sbjct: 486 FEATMIDRKIGDKPISFEVSIGNFGNLIDGGSHHGSKKSAESAEEDLLPLLHEGQGDVAH 545

Query: 599 ----PLASTTQYSR-AVFDGN-YYYYLPWAHTKPVVTLTSYWEDISHRLDAVNTLLAMAE 652
               P+ASTT   +  V +GN  Y YLP+   KP V   S W D + RL   N L  MA+
Sbjct: 546 DVPIPMASTTHPEKPLVTEGNRNYNYLPFEAKKPCVYFISSWGDQTFRLHWSNMLEKMAD 605

Query: 653 RLQTNIEALKSGIQGKIPANQLAELWLKLIDEVIEDTRYTLPLTEGK---ANVTVLDTQI 709
            L+ +IE ++  I  KI      E    ++ + I  +   +   E K    N T LD + 
Sbjct: 606 FLEESIEEVRELI--KISQEAPEEKMKTVLSDFISRSSAFISEAEKKPKMLNQTTLDKKR 663

Query: 710 RKLRSRSLSQIHEAA---VRMRSEATDVKSTLAEIEDWLDKLMQLTEEPQNSMPDIIIWM 766
             L  + L  + + A   ++ + +   V   + E +++++K+  L +EPQ+++PD+ IWM
Sbjct: 664 LTLCWQELEAMCKEAKGIIQQQKKKLSVDEMIHEAQNFVEKIRFLVDEPQHTIPDVFIWM 723

Query: 767 IRGEKRLAYARIPAHQVLYSTSGENASGKYCGKTQTIFLKYPQEKNNGPKVPVELRVNIW 826
           +   +R+AYARI +  +LYS       GK+CGK +T FLK P ++  G  V  ++ V +W
Sbjct: 724 LSNNRRVAYARIASKDLLYSPVA-GQMGKHCGKIKTHFLKPPGKRPAGWSVQAKVDVYLW 782

Query: 827 LG 828
           LG
Sbjct: 783 LG 784



 Score = 38.1 bits (87), Expect = 0.089
 Identities = 34/120 (28%), Positives = 51/120 (42%), Gaps = 11/120 (9%)

Query: 18  GKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFD---LRGIPLDFSSSLGIIV---KD 71
           G  DP   V F    + TK +   L+P WN++L F+   L G   + + S  ++V    D
Sbjct: 845 GLSDPFAKVTFLSHCQTTKIISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVVELYD 904

Query: 72  FETIGQNKLIGTATVALKDLTGDQSRSLP---YKLISLLNEKGQDTGATIDLVIGYDPPS 128
            + +G+ + +G    A      DQ    P   Y  I   N  G D  A  +L+    PPS
Sbjct: 905 SDAVGKPEYLGATVAAPVVKLADQDYEPPRLCYHPIFCGNLSGGDLLAVFELL--QVPPS 962



 Score = 37.0 bits (84), Expect = 0.20
 Identities = 24/77 (31%), Positives = 37/77 (48%), Gaps = 8/77 (10%)

Query: 389 ADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVV--NLQIKFPSVCE------KIKL 440
           AD   L DPF +V+F      T II +  +P WNQ++  N  +    V E       + +
Sbjct: 841 ADSNGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVV 900

Query: 441 TIYDWDRLTKNDVVGTT 457
            +YD D + K + +G T
Sbjct: 901 ELYDSDAVGKPEYLGAT 917



 Score = 32.0 bits (71), Expect = 6.4
 Identities = 23/69 (33%), Positives = 36/69 (52%), Gaps = 2/69 (2%)

Query: 21  DPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLD-FSSSLGIIVKDFETIGQNK 79
           DP+V++   DEKK++   +   +P +NE   FD  G  +  F   + I V   + IG + 
Sbjct: 101 DPVVTIEIGDEKKQSTVKEGTNSPFYNEYFVFDFIGPQVHLFDKIIKISVFHHKLIG-SV 159

Query: 80  LIGTATVAL 88
           LIG+  V L
Sbjct: 160 LIGSFKVDL 168


>gi|35493868 otoferlin isoform b [Homo sapiens]
          Length = 1230

 Score =  688 bits (1775), Expect = 0.0
 Identities = 393/1039 (37%), Positives = 576/1039 (55%), Gaps = 119/1039 (11%)

Query: 1114 PIVSCNFDRVYIYHLRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTW 1173
            P VS  + +   + LR ++YQAR+L A D    SDP+A + F+++S+ TE+++ TL PTW
Sbjct: 201  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 260

Query: 1174 DQTIIFDEVEIYGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVVKLNSEM---- 1229
            DQ ++FD +E+YGE   +  +PP +++E++D D +GK +F+GR+   P+VK+  E     
Sbjct: 261  DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 320

Query: 1230 DITPKLLWHPVMNGDKACGDVLVTAELILRGKDGSNLPILPPQRAP------NLYMVPQG 1283
               P+L ++ +  G+   GD+L   EL+  G  G     LPP   P       +  VP G
Sbjct: 321  RFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGK--ADLPPINGPVDVDRGPIMPVPMG 378

Query: 1284 IRPVVQLTAIEILAWGLRNMKNFQMASITSPSLVVECGGERVESVVIKNLKKTPNFPSSV 1343
            IRPV+    +E+L WGLR++K   +A +  P + +EC G+ V+S +I N KK PNF + V
Sbjct: 379  IRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLV 438

Query: 1344 LFMKVFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTIERLDRF---------------- 1387
             + +V LP+ EL  PPL I+V+D R FGR  +VG   +  L RF                
Sbjct: 439  KWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYRPPDRSAPSWNTTG 498

Query: 1388 ----RCDPYAGKEDIVPQLKASLLSAPPCR-DIVIEMEDTKPLLASKLTEKEEE-----I 1437
                  +P    + +   +K    S    + D+  E ++ K        E EEE     +
Sbjct: 499  EVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESM 558

Query: 1438 VDWWSKFYASSG-------EHEKCGQYIQ---------------KGYSKLKIYNCELENV 1475
            +DWWSK++AS         + E  G  ++               KG  K +    E +  
Sbjct: 559  LDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKK 618

Query: 1476 AEFEG----------------------------LTDFSD---TFKLYRGKSDENEDPS-- 1502
             +  G                              +F D   TF L RGK+ ++ED S  
Sbjct: 619  TQSSGSGQGSEAPEKKKPKIDELKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTE 678

Query: 1503 ---VVGEFKGSFRIY--PLPDDPSVPA----PPRQFRELPDSVPQECTVRIYIVRGLELQ 1553
               +VG FKGS  +Y  PLP+D S  A        F+ +P + P    VR+Y+VR  +L 
Sbjct: 679  EERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLH 738

Query: 1554 PQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLPQEKDLKISVYDYD 1613
            P D NG  DPYI I LGK  I D+++YI   LNPVFG+ +++    P E  L ++VYD+D
Sbjct: 739  PADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWD 798

Query: 1614 TFTRDEKVGETIIDLENRFLSRFGSHCGIPEEYCVSGVNTWRDQLRPTQLLQNVARFKGF 1673
                D+ +GET IDLENRF S+  + CGI + Y   G N WRD ++P+Q+L  + +    
Sbjct: 799  LVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKV 858

Query: 1674 PQPILSEDGSRIRYGGRDYS-----LDEFEANKILHQHLGAPEERLALHILRTQ-GLVPE 1727
              P     G R++   R ++      DE    K   +H+     R    I R    LVPE
Sbjct: 859  DGPHFGPPG-RVKVANRVFTGPSEIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPE 917

Query: 1728 HVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGPPFNITPRKAKKYYLRVIIWNTKDV 1787
            HVETR L +  +P I QG+L++WVD+FP  +  PG P +I+PRK KKY LRVIIWNT +V
Sbjct: 918  HVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEV 977

Query: 1788 IL-DEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYRSLDGEGNFNWRFVFPFDYLPAEQ 1846
            +L D+   TGE+ SDI+V+GW+ G +E+KQ TDVHY SL GEGNFNWR++FPFDYL AE+
Sbjct: 978  VLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEE 1037

Query: 1847 LCIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSLDDYLGFLELDLRHTIIPAKSPEKC 1906
              +++KKE  +S D+TE++IP RL +QIWD D FS DD+LG +ELDL      AK+ ++C
Sbjct: 1038 KIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQC 1097

Query: 1907 RLDMIPDLKAMNPLKAKTASLFEQKSMKGWWPCYAEKDGARV-MAGKVEMTLEILNEKEA 1965
             ++M     A   +     S+F+QK +KGWWP  A  +     + GKVE  L +L  +EA
Sbjct: 1098 TMEM-----ATGEVDVPLVSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEA 1152

Query: 1966 DERPAGKGRDEPNMNPKLDLPNRPETSFLWFTNPCKTMKFIVWRRFKWVIIGLLFLLILL 2025
            ++ P G  R+EP+    L+ PNRP+TSF+WF NP K+ ++ +W  ++W+++ LL LL+LL
Sbjct: 1153 EKNPVGLARNEPD---PLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLL 1209

Query: 2026 LFVAVLLYSLPNYLSMKIV 2044
            L +A+ LYS+P YL  KI+
Sbjct: 1210 LLLALFLYSVPGYLVKKIL 1228



 Score = 91.7 bits (226), Expect = 7e-18
 Identities = 53/145 (36%), Positives = 85/145 (58%), Gaps = 6/145 (4%)

Query: 697 EGKANVTVLDTQIRKLRSRSLSQIHEAAVRMRSEAT--DVKSTLAEIEDWLDKLMQLTEE 754
           +G ++ T LD +  K   R L  + + A  +R++     V+  L   +++L KL  L +E
Sbjct: 35  QGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADE 94

Query: 755 PQNSMPDIIIWMIRGEKRLAYARIPAHQVLYSTSGENASGKYCGKTQTIFLKYPQEKNNG 814
           PQ+S+PDI IWM+   KR+AYAR+P+  +L+S   E  +GK C K +T+FLK P ++  G
Sbjct: 95  PQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIV-EEETGKDCAKVKTLFLKLPGKRGFG 153

Query: 815 P---KVPVELRVNIWLGLSAVEKKF 836
                V  ++ + +WLGLS   K+F
Sbjct: 154 SAGWTVQAKVELYLWLGLSKQRKEF 178



 Score = 41.6 bits (96), Expect = 0.008
 Identities = 24/78 (30%), Positives = 38/78 (48%), Gaps = 8/78 (10%)

Query: 389 ADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVV---NLQI-----KFPSVCEKIKL 440
           AD   L DPF  V F  +  CT ++ +   P W+Q++   NL++     +       I +
Sbjct: 228 ADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVI 287

Query: 441 TIYDWDRLTKNDVVGTTY 458
            IYD D + K D +G T+
Sbjct: 288 EIYDQDSMGKADFMGRTF 305



 Score = 37.7 bits (86), Expect = 0.12
 Identities = 19/75 (25%), Positives = 36/75 (48%), Gaps = 3/75 (4%)

Query: 389 ADKKNLVDPFVEVSFAGKKVCT--NIIEKNANPEWNQVVNLQIKFPSVCEKIKLTIYDWD 446
           AD     DP++ +      +    N I K  NP + +  +++  FP     + + +YDWD
Sbjct: 740 ADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPME-SMLTVAVYDWD 798

Query: 447 RLTKNDVVGTTYLHL 461
            +  +D++G T + L
Sbjct: 799 LVGTDDLIGETKIDL 813



 Score = 32.3 bits (72), Expect = 4.9
 Identities = 24/95 (25%), Positives = 46/95 (48%), Gaps = 3/95 (3%)

Query: 193 SNKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNNPFFDEL---FFYNV 249
           SN P +  +RV V+    L   +I      ++  +  +T I+   N    +L   F  + 
Sbjct: 719 SNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSF 778

Query: 250 NMTPSELMDEIISIRVYNSHSLRADCLMGEFKIDV 284
           ++  S  M+ ++++ VY+   +  D L+GE KID+
Sbjct: 779 DIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDL 813


>gi|35493853 otoferlin isoform c [Homo sapiens]
          Length = 1307

 Score =  684 bits (1764), Expect = 0.0
 Identities = 395/1062 (37%), Positives = 580/1062 (54%), Gaps = 145/1062 (13%)

Query: 1114 PIVSCNFDRVYIYHLRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTW 1173
            P VS  + +   + LR ++YQAR+L A D    SDP+A + F+++S+ TE+++ TL PTW
Sbjct: 258  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 317

Query: 1174 DQTIIFDEVEIYGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVVKLNSEM---- 1229
            DQ ++FD +E+YGE   +  +PP +++E++D D +GK +F+GR+   P+VK+  E     
Sbjct: 318  DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 377

Query: 1230 DITPKLLWHPVMNGDKACGDVLVTAELILRGKDGSNLPILPPQRAP------NLYMVPQG 1283
               P+L ++ +  G+   GD+L   EL+  G  G     LPP   P       +  VP G
Sbjct: 378  RFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGK--ADLPPINGPVDVDRGPIMPVPMG 435

Query: 1284 IRPVVQLTAIEILAWGLRNMKNFQMASITSPSLVVECGGERVESVVIKNLKKTPNFPSSV 1343
            IRPV+    +E+L WGLR++K   +A +  P + +EC G+ V+S +I N KK PNF + V
Sbjct: 436  IRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLV 495

Query: 1344 LFMKVFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTIERLDRFRCDPYAGKEDIVPQLK 1403
             + +V LP+ EL  PPL I+V+D R FGR  +VG   +  L RF    Y   +   P   
Sbjct: 496  KWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRF---IYRPPDRSAPSWN 552

Query: 1404 ASLLSAPPCR-------------DIVIEMEDTKPL--------------------LASKL 1430
             ++     CR             ++V+ ME   P+                    +A + 
Sbjct: 553  TTVRLLRRCRVLCNGGSSSHSTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEE 612

Query: 1431 TEK----------------EEEIVDWWSKFYASSG-------EHEKCGQYIQ-------- 1459
             EK                +E ++DWWSK++AS         + E  G  ++        
Sbjct: 613  KEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNT 672

Query: 1460 -------KGYSKLKIYNCELENVAEFEG----------------------------LTDF 1484
                   KG  K +    E +   +  G                              +F
Sbjct: 673  EGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDELKVYPKELESEFDNF 732

Query: 1485 SD---TFKLYRGKSDENEDPS-----VVGEFKGSFRIY--PLPDDPSVPA----PPRQFR 1530
             D   TF L RGK+ ++ED S     +VG FKGS  +Y  PLP+D S  A        F+
Sbjct: 733  EDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQ 792

Query: 1531 ELPDSVPQECTVRIYIVRGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFG 1590
             +P + P    VR+Y+VR  +L P D NG  DPYI I LGK  I D+++YI   LNPVFG
Sbjct: 793  GIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFG 852

Query: 1591 RMYELSCYLPQEKDLKISVYDYDTFTRDEKVGETIIDLENRFLSRFGSHCGIPEEYCVSG 1650
            + +++    P E  L ++VYD+D    D+ +GET IDLENRF S+  + CGI + Y   G
Sbjct: 853  KSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHG 912

Query: 1651 VNTWRDQLRPTQLLQNVARFKGFPQPILSEDGSRIRYGGRDYS-----LDEFEANKILHQ 1705
             N WRD ++P+Q+L  + +      P     G R++   R ++      DE    K   +
Sbjct: 913  YNIWRDPMKPSQILTRLCKDGKVDGPHFGPPG-RVKVANRVFTGPSEIEDENGQRKPTDE 971

Query: 1706 HLGAPEERLALHILRTQ-GLVPEHVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGPP 1764
            H+     R    I R    LVPEHVETR L +  +P I QG+L++WVD+FP  +  PG P
Sbjct: 972  HVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTP 1031

Query: 1765 FNITPRKAKKYYLRVIIWNTKDVIL-DEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYR 1823
             +I+PRK KKY LRVIIWNT +V+L D+   TGE+ SDI+V+GW+ G +E+KQ TDVHY 
Sbjct: 1032 LDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYH 1091

Query: 1824 SLDGEGNFNWRFVFPFDYLPAEQLCIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSLD 1883
            SL GEGNFNWR++FPFDYL AE+  +++KKE  +S D+TE++IP RL +QIWD D FS D
Sbjct: 1092 SLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSAD 1151

Query: 1884 DYLGFLELDLRHTIIPAKSPEKCRLDMIPDLKAMNPLKAKTASLFEQKSMKGWWPCYAEK 1943
            D+LG +ELDL      AK+ ++C ++M     A   +     S+F+QK +KGWWP  A  
Sbjct: 1152 DFLGAIELDLNRFPRGAKTAKQCTMEM-----ATGEVDVPLVSIFKQKRVKGWWPLLARN 1206

Query: 1944 DGARV-MAGKVEMTLEILNEKEADERPAGKGRDEPNMNPKLDLPNRPETSFLWFTNPCKT 2002
            +     + GKVE  L +L  +EA++ P G  R+EP+    L+ PNRP+TSF+WF NP K+
Sbjct: 1207 ENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPD---PLEKPNRPDTSFIWFLNPLKS 1263

Query: 2003 MKFIVWRRFKWVIIGLLFLLILLLFVAVLLYSLPNYLSMKIV 2044
             ++ +W  ++W+++ LL LL+LLL +A+ LYS+P YL  KI+
Sbjct: 1264 ARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKIL 1305



 Score = 91.7 bits (226), Expect = 7e-18
 Identities = 53/145 (36%), Positives = 85/145 (58%), Gaps = 6/145 (4%)

Query: 697 EGKANVTVLDTQIRKLRSRSLSQIHEAAVRMRSEAT--DVKSTLAEIEDWLDKLMQLTEE 754
           +G ++ T LD +  K   R L  + + A  +R++     V+  L   +++L KL  L +E
Sbjct: 92  QGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADE 151

Query: 755 PQNSMPDIIIWMIRGEKRLAYARIPAHQVLYSTSGENASGKYCGKTQTIFLKYPQEKNNG 814
           PQ+S+PDI IWM+   KR+AYAR+P+  +L+S   E  +GK C K +T+FLK P ++  G
Sbjct: 152 PQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIV-EEETGKDCAKVKTLFLKLPGKRGFG 210

Query: 815 P---KVPVELRVNIWLGLSAVEKKF 836
                V  ++ + +WLGLS   K+F
Sbjct: 211 SAGWTVQAKVELYLWLGLSKQRKEF 235



 Score = 41.6 bits (96), Expect = 0.008
 Identities = 24/78 (30%), Positives = 38/78 (48%), Gaps = 8/78 (10%)

Query: 389 ADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVV---NLQI-----KFPSVCEKIKL 440
           AD   L DPF  V F  +  CT ++ +   P W+Q++   NL++     +       I +
Sbjct: 285 ADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVI 344

Query: 441 TIYDWDRLTKNDVVGTTY 458
            IYD D + K D +G T+
Sbjct: 345 EIYDQDSMGKADFMGRTF 362



 Score = 37.7 bits (86), Expect = 0.12
 Identities = 19/75 (25%), Positives = 36/75 (48%), Gaps = 3/75 (4%)

Query: 389 ADKKNLVDPFVEVSFAGKKVCT--NIIEKNANPEWNQVVNLQIKFPSVCEKIKLTIYDWD 446
           AD     DP++ +      +    N I K  NP + +  +++  FP     + + +YDWD
Sbjct: 817 ADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPME-SMLTVAVYDWD 875

Query: 447 RLTKNDVVGTTYLHL 461
            +  +D++G T + L
Sbjct: 876 LVGTDDLIGETKIDL 890



 Score = 32.3 bits (72), Expect = 4.9
 Identities = 24/95 (25%), Positives = 46/95 (48%), Gaps = 3/95 (3%)

Query: 193 SNKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNNPFFDEL---FFYNV 249
           SN P +  +RV V+    L   +I      ++  +  +T I+   N    +L   F  + 
Sbjct: 796 SNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSF 855

Query: 250 NMTPSELMDEIISIRVYNSHSLRADCLMGEFKIDV 284
           ++  S  M+ ++++ VY+   +  D L+GE KID+
Sbjct: 856 DIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDL 890


>gi|34740331 otoferlin isoform a [Homo sapiens]
          Length = 1997

 Score =  684 bits (1764), Expect = 0.0
 Identities = 395/1062 (37%), Positives = 580/1062 (54%), Gaps = 145/1062 (13%)

Query: 1114 PIVSCNFDRVYIYHLRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTW 1173
            P VS  + +   + LR ++YQAR+L A D    SDP+A + F+++S+ TE+++ TL PTW
Sbjct: 948  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 1007

Query: 1174 DQTIIFDEVEIYGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVVKLNSEM---- 1229
            DQ ++FD +E+YGE   +  +PP +++E++D D +GK +F+GR+   P+VK+  E     
Sbjct: 1008 DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 1067

Query: 1230 DITPKLLWHPVMNGDKACGDVLVTAELILRGKDGSNLPILPPQRAP------NLYMVPQG 1283
               P+L ++ +  G+   GD+L   EL+  G  G     LPP   P       +  VP G
Sbjct: 1068 RFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGK--ADLPPINGPVDVDRGPIMPVPMG 1125

Query: 1284 IRPVVQLTAIEILAWGLRNMKNFQMASITSPSLVVECGGERVESVVIKNLKKTPNFPSSV 1343
            IRPV+    +E+L WGLR++K   +A +  P + +EC G+ V+S +I N KK PNF + V
Sbjct: 1126 IRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLV 1185

Query: 1344 LFMKVFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTIERLDRFRCDPYAGKEDIVPQLK 1403
             + +V LP+ EL  PPL I+V+D R FGR  +VG   +  L RF    Y   +   P   
Sbjct: 1186 KWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRF---IYRPPDRSAPSWN 1242

Query: 1404 ASLLSAPPCR-------------DIVIEMEDTKPL--------------------LASKL 1430
             ++     CR             ++V+ ME   P+                    +A + 
Sbjct: 1243 TTVRLLRRCRVLCNGGSSSHSTGEVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEE 1302

Query: 1431 TEK----------------EEEIVDWWSKFYASSG-------EHEKCGQYIQ-------- 1459
             EK                +E ++DWWSK++AS         + E  G  ++        
Sbjct: 1303 KEKKKKKKGTAEEPEEEEPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNT 1362

Query: 1460 -------KGYSKLKIYNCELENVAEFEG----------------------------LTDF 1484
                   KG  K +    E +   +  G                              +F
Sbjct: 1363 EGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDELKVYPKELESEFDNF 1422

Query: 1485 SD---TFKLYRGKSDENEDPS-----VVGEFKGSFRIY--PLPDDPSVPA----PPRQFR 1530
             D   TF L RGK+ ++ED S     +VG FKGS  +Y  PLP+D S  A        F+
Sbjct: 1423 EDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQ 1482

Query: 1531 ELPDSVPQECTVRIYIVRGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFG 1590
             +P + P    VR+Y+VR  +L P D NG  DPYI I LGK  I D+++YI   LNPVFG
Sbjct: 1483 GIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFG 1542

Query: 1591 RMYELSCYLPQEKDLKISVYDYDTFTRDEKVGETIIDLENRFLSRFGSHCGIPEEYCVSG 1650
            + +++    P E  L ++VYD+D    D+ +GET IDLENRF S+  + CGI + Y   G
Sbjct: 1543 KSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHG 1602

Query: 1651 VNTWRDQLRPTQLLQNVARFKGFPQPILSEDGSRIRYGGRDYS-----LDEFEANKILHQ 1705
             N WRD ++P+Q+L  + +      P     G R++   R ++      DE    K   +
Sbjct: 1603 YNIWRDPMKPSQILTRLCKDGKVDGPHFGPPG-RVKVANRVFTGPSEIEDENGQRKPTDE 1661

Query: 1706 HLGAPEERLALHILRTQ-GLVPEHVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGPP 1764
            H+     R    I R    LVPEHVETR L +  +P I QG+L++WVD+FP  +  PG P
Sbjct: 1662 HVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTP 1721

Query: 1765 FNITPRKAKKYYLRVIIWNTKDVIL-DEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYR 1823
             +I+PRK KKY LRVIIWNT +V+L D+   TGE+ SDI+V+GW+ G +E+KQ TDVHY 
Sbjct: 1722 LDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYH 1781

Query: 1824 SLDGEGNFNWRFVFPFDYLPAEQLCIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSLD 1883
            SL GEGNFNWR++FPFDYL AE+  +++KKE  +S D+TE++IP RL +QIWD D FS D
Sbjct: 1782 SLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSAD 1841

Query: 1884 DYLGFLELDLRHTIIPAKSPEKCRLDMIPDLKAMNPLKAKTASLFEQKSMKGWWPCYAEK 1943
            D+LG +ELDL      AK+ ++C ++M     A   +     S+F+QK +KGWWP  A  
Sbjct: 1842 DFLGAIELDLNRFPRGAKTAKQCTMEM-----ATGEVDVPLVSIFKQKRVKGWWPLLARN 1896

Query: 1944 DGARV-MAGKVEMTLEILNEKEADERPAGKGRDEPNMNPKLDLPNRPETSFLWFTNPCKT 2002
            +     + GKVE  L +L  +EA++ P G  R+EP+    L+ PNRP+TSF+WF NP K+
Sbjct: 1897 ENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPD---PLEKPNRPDTSFIWFLNPLKS 1953

Query: 2003 MKFIVWRRFKWVIIGLLFLLILLLFVAVLLYSLPNYLSMKIV 2044
             ++ +W  ++W+++ LL LL+LLL +A+ LYS+P YL  KI+
Sbjct: 1954 ARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKIL 1995



 Score =  365 bits (938), Expect = e-100
 Identities = 286/941 (30%), Positives = 457/941 (48%), Gaps = 152/941 (16%)

Query: 18  GKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLR-----GIPLDFSSSLGIIVKDF 72
           G+ D I  V F+ +   ++ ++N       ++ +FD          +D +  L I V ++
Sbjct: 15  GRGDRIAKVTFRGQSFYSRVLEN-----CEDVADFDETFRWPVASSIDRNEMLEIQVFNY 69

Query: 73  ETIGQNKLIGTATVALKDLTGDQSRSLPYKLIS--------------------------- 105
             +  NKLIGT  + L+ +  +    +   LI                            
Sbjct: 70  SKVFSNKLIGTFRMVLQKVVEESHVEVTDTLIDDNNAIIKTSLCVEVRYQATDGTVGSWD 129

Query: 106 --------LLNEKGQDTGATIDLVIGYDPPSAPHPNDLS----GPSV-------PGMGGD 146
                    L E+ +D+  T  L+ G  P S P P + S    G SV             
Sbjct: 130 DGDFLGDESLQEEEKDSQETDGLLPGSRPSSRP-PGEKSFRRAGRSVFSAMKLGKNRSHK 188

Query: 147 GEEDEGDE------DRLDNAVRGPGPKGPVGTVSEAQLARRLTKVKNSRRM-------LS 193
            E    DE      + LD+     G      +VS A +    T V N R          +
Sbjct: 189 EEPQRPDEPAVLEMEDLDHLAIRLGDGLDPDSVSLASVTALTTNVSNKRSKPDIKMEPSA 248

Query: 194 NKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNN-PFFDELFFYNVNMT 252
            +P D+Q+ + VIE RQL G N+ PVV V V      T +K   N P+++E F ++ +++
Sbjct: 249 GRPMDYQVSITVIEARQLVGLNMDPVVCVEVGDDKKYTSMKESTNCPYYNEYFVFDFHVS 308

Query: 253 PSELMDEIISIRVYNSHSL-RADCLMGEFKIDVGFVYDEPGHAVMRKWLLLNDPEDTSSG 311
           P  + D+II I V +S +L R+  L+G FK+DVG VY +P H    KW +L+DP+D SSG
Sbjct: 309 PDVMFDKIIKISVIHSKNLLRSGTLVGSFKMDVGTVYSQPEHQFHHKWAILSDPDDISSG 368

Query: 312 SKGYMKVSMFVLGTGDEPPPERRDRDNDSDDVESNLLLPAGI--ALRWVTFLLKIYRAED 369
            KGY+K  + V+G GD      +  + D DD+E NLLLP G+    +W  F +KIYRAE 
Sbjct: 369 LKGYVKCDVAVVGKGDNIKTPHKANETDEDDIEGNLLLPEGVPPERQWARFYVKIYRAEG 428

Query: 370 IPQMDDAFSQTVKEIFGGNADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVVNLQI 429
           +P+M+ +    VK+ F G  + K+LVDP+V+V FAG+K  T++ + +  P WN+ V    
Sbjct: 429 LPRMNTSLMANVKKAFIG--ENKDLVDPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTD 486

Query: 430 KFPSVCEKIKLTIYDWDRLTKNDV-VGTTYLHLSKIAASGGEVEVNTGETEVGFVPTFGP 488
            FP +C+++K+ I D D++  NDV +GT ++ L KI+  G          + GF+PT GP
Sbjct: 487 LFPPLCKRMKVQIRDSDKV--NDVAIGTHFIDLRKISNDG----------DKGFLPTLGP 534

Query: 489 CYLNLYGSPREYTGFPDPYDELNTGKGEGVAYRGRILVELATFLEKTPPDKKLEPISNDD 548
            ++N+YGS R YT   D + +LN G GEGV++R R+L+ LA  +  T      E  S+ +
Sbjct: 535 AWVNMYGSTRNYT-LLDEHQDLNEGLGEGVSFRARLLLGLAVEIVDT---SNPELTSSTE 590

Query: 549 LLVVEKYQ-------RRRKYSLSAVFHSATML--QDVGEAIQFEVSIGNYGNKFDTTCKP 599
           + V +          +  ++ L   F  A+M+  ++  + I FEV+IGNYGN+ D   +P
Sbjct: 591 VQVEQATPISESCAGKMEEFFLFGAFLEASMIDRRNGDKPITFEVTIGNYGNEVDGLSRP 650

Query: 600 ----------------------------------LASTTQYSRAVFDGNYYYYLPWAHTK 625
                                             ++ST      V D N Y++LP+   K
Sbjct: 651 QRPRPRKEPGDEEEVDLIQNASDDEAGDAGDLASVSSTPPMRPQVTDRN-YFHLPYLERK 709

Query: 626 PVVTLTSYWEDISHRLDAVNTLLAMAERLQTNIEALKSGI--QGKIPANQLAELWLKLID 683
           P + + S+W D   RL   N +  +A++L+  +  ++  I  +   P  +L      +++
Sbjct: 710 PCIYIKSWWPDQRRRLYNANIMDHIADKLEEGLNDIQEMIKTEKSYPERRLR----GVLE 765

Query: 684 EVIEDTRYTLPLT---EGKANVTVLDTQIRKLRSRSLSQIHEAAVRMRSEAT--DVKSTL 738
           E+       L L    +G ++ T LD +  K   R L  + + A  +R++     V+  L
Sbjct: 766 ELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKL 825

Query: 739 AEIEDWLDKLMQLTEEPQNSMPDIIIWMIRGEKRLAYARIPAHQVLYSTSGENASGKYCG 798
              +++L KL  L +EPQ+S+PDI IWM+   KR+AYAR+P+  +L+S   E  +GK C 
Sbjct: 826 RLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIV-EEETGKDCA 884

Query: 799 KTQTIFLKYPQEKNNGP---KVPVELRVNIWLGLSAVEKKF 836
           K +T+FLK P ++  G     V  ++ + +WLGLS   K+F
Sbjct: 885 KVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEF 925



 Score = 41.6 bits (96), Expect = 0.008
 Identities = 24/78 (30%), Positives = 38/78 (48%), Gaps = 8/78 (10%)

Query: 389  ADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVV---NLQI-----KFPSVCEKIKL 440
            AD   L DPF  V F  +  CT ++ +   P W+Q++   NL++     +       I +
Sbjct: 975  ADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVI 1034

Query: 441  TIYDWDRLTKNDVVGTTY 458
             IYD D + K D +G T+
Sbjct: 1035 EIYDQDSMGKADFMGRTF 1052



 Score = 37.7 bits (86), Expect = 0.12
 Identities = 19/75 (25%), Positives = 36/75 (48%), Gaps = 3/75 (4%)

Query: 389  ADKKNLVDPFVEVSFAGKKVCT--NIIEKNANPEWNQVVNLQIKFPSVCEKIKLTIYDWD 446
            AD     DP++ +      +    N I K  NP + +  +++  FP     + + +YDWD
Sbjct: 1507 ADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPME-SMLTVAVYDWD 1565

Query: 447  RLTKNDVVGTTYLHL 461
             +  +D++G T + L
Sbjct: 1566 LVGTDDLIGETKIDL 1580



 Score = 33.5 bits (75), Expect = 2.2
 Identities = 24/89 (26%), Positives = 42/89 (47%), Gaps = 7/89 (7%)

Query: 10  SNIPKTKFGKP----DPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLDFSSSL 65
           +N+ K   G+     DP V V F  +K KT    +   P+WNE + F     PL     +
Sbjct: 438 ANVKKAFIGENKDLVDPYVQVFFAGQKGKTSVQKSSYEPLWNEQVVFTDLFPPL--CKRM 495

Query: 66  GIIVKDFETIGQNKLIGTATVALKDLTGD 94
            + ++D + +  +  IGT  + L+ ++ D
Sbjct: 496 KVQIRDSDKV-NDVAIGTHFIDLRKISND 523



 Score = 32.3 bits (72), Expect = 4.9
 Identities = 24/95 (25%), Positives = 46/95 (48%), Gaps = 3/95 (3%)

Query: 193  SNKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNNPFFDEL---FFYNV 249
            SN P +  +RV V+    L   +I      ++  +  +T I+   N    +L   F  + 
Sbjct: 1486 SNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSF 1545

Query: 250  NMTPSELMDEIISIRVYNSHSLRADCLMGEFKIDV 284
            ++  S  M+ ++++ VY+   +  D L+GE KID+
Sbjct: 1546 DIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDL 1580


>gi|35493860 otoferlin isoform d [Homo sapiens]
          Length = 1230

 Score =  681 bits (1756), Expect = 0.0
 Identities = 390/1039 (37%), Positives = 575/1039 (55%), Gaps = 119/1039 (11%)

Query: 1114 PIVSCNFDRVYIYHLRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTW 1173
            P VS  + +   + LR ++YQAR+L A D    SDP+A + F+++S+ TE+++ TL PTW
Sbjct: 201  PPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTW 260

Query: 1174 DQTIIFDEVEIYGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVVKLNSEM---- 1229
            DQ ++FD +E+YGE   +  +PP +++E++D D +GK +F+GR+   P+VK+  E     
Sbjct: 261  DQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPP 320

Query: 1230 DITPKLLWHPVMNGDKACGDVLVTAELILRGKDGSNLPILPPQRAP------NLYMVPQG 1283
               P+L ++ +  G+   GD+L   EL+  G  G     LPP   P       +  VP G
Sbjct: 321  RFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGK--ADLPPINGPVDVDRGPIMPVPMG 378

Query: 1284 IRPVVQLTAIEILAWGLRNMKNFQMASITSPSLVVECGGERVESVVIKNLKKTPNFPSSV 1343
            IRPV+    +E+L WGLR++K   +A +  P + +EC G+ V+S +I N KK PNF + V
Sbjct: 379  IRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLV 438

Query: 1344 LFMKVFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTIERLDRF---------------- 1387
             + +V LP+ EL  PPL I+V+D R FGR  +VG   +  L RF                
Sbjct: 439  KWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYRPPDRSAPSWNTTG 498

Query: 1388 ----RCDPYAGKEDIVPQLKASLLSAPPCR-DIVIEMEDTKPLLASKLTEKEEE-----I 1437
                  +P    + +   +K    S    + D+  E ++ K        E EEE     +
Sbjct: 499  EVVVTMEPEVPIKKLETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEEEPDESM 558

Query: 1438 VDWWSKFYASSG-------EHEKCGQYIQ---------------KGYSKLKIYNCELENV 1475
            +DWWSK++AS         + E  G  ++               KG  K +    E +  
Sbjct: 559  LDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKK 618

Query: 1476 AEFEG----------------------------LTDFSD---TFKLYRGKSDENEDPS-- 1502
             +  G                              +F D   TF L RGK+ ++ED S  
Sbjct: 619  TQSSGSGQGSEAPEKKKPKIDELKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTE 678

Query: 1503 ---VVGEFKGSFRIY--PLPDDPSVPA----PPRQFRELPDSVPQECTVRIYIVRGLELQ 1553
               +VG FKGS  +Y  PLP+D S  A        F+ +P + P    VR+Y+VR  +L 
Sbjct: 679  EERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLH 738

Query: 1554 PQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLPQEKDLKISVYDYD 1613
            P D NG  DPYI I LGK  I D+++YI   LNPVFG+ +++    P E  L ++VYD+D
Sbjct: 739  PADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWD 798

Query: 1614 TFTRDEKVGETIIDLENRFLSRFGSHCGIPEEYCVSGVNTWRDQLRPTQLLQNVARFKGF 1673
                D+ +GET IDLENRF S+  + CGI + Y   G N WRD ++P+Q+L  + +    
Sbjct: 799  LVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKV 858

Query: 1674 PQPILSEDGSRIRYGGRDYS-----LDEFEANKILHQHLGAPEERLALHILRTQ-GLVPE 1727
              P     G R++   R ++      DE    K   +H+     R    I R    LVPE
Sbjct: 859  DGPHFGPPG-RVKVANRVFTGPSEIEDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPE 917

Query: 1728 HVETRTLHSTFQPNISQGKLQMWVDVFPKSLGPPGPPFNITPRKAKKYYLRVIIWNTKDV 1787
            HVETR L +  +P I QG+L++WVD+FP  +  PG P +I+PRK KKY LRVIIWNT +V
Sbjct: 918  HVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEV 977

Query: 1788 IL-DEKSITGEEMSDIYVKGWIPGNEENKQKTDVHYRSLDGEGNFNWRFVFPFDYLPAEQ 1846
            +L D+   TGE+ SDI+V+GW+ G +E+KQ TDVHY SL GEGNFNWR++FPFDYL AE+
Sbjct: 978  VLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEE 1037

Query: 1847 LCIVAKKEHFWSIDQTEFRIPPRLIIQIWDNDKFSLDDYLGFLELDLRHTIIPAKSPEKC 1906
              +++KKE  +S D+TE++IP RL +QIWD D FS DD+LG +ELDL      AK+ ++C
Sbjct: 1038 KIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQC 1097

Query: 1907 RLDMIPDLKAMNPLKAKTASLFEQKSMKGWWPCYAEKDGARV-MAGKVEMTLEILNEKEA 1965
             ++M     A   +     S+F+QK +KGWWP  A  +     + GKVE  L +L  +EA
Sbjct: 1098 TMEM-----ATGEVDVPLVSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEA 1152

Query: 1966 DERPAGKGRDEPNMNPKLDLPNRPETSFLWFTNPCKTMKFIVWRRFKWVIIGLLFLLILL 2025
            ++ P G  R+EP+    L+ PNRP+T+F+WF NP K++K+++  R+KW+II ++  L+ L
Sbjct: 1153 EKNPVGLARNEPD---PLEKPNRPDTAFVWFLNPLKSIKYLICTRYKWLIIKIVLALLGL 1209

Query: 2026 LFVAVLLYSLPNYLSMKIV 2044
            L + + LYSLP Y+  K++
Sbjct: 1210 LMLGLFLYSLPGYMVKKLL 1228



 Score = 91.7 bits (226), Expect = 7e-18
 Identities = 53/145 (36%), Positives = 85/145 (58%), Gaps = 6/145 (4%)

Query: 697 EGKANVTVLDTQIRKLRSRSLSQIHEAAVRMRSEAT--DVKSTLAEIEDWLDKLMQLTEE 754
           +G ++ T LD +  K   R L  + + A  +R++     V+  L   +++L KL  L +E
Sbjct: 35  QGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADE 94

Query: 755 PQNSMPDIIIWMIRGEKRLAYARIPAHQVLYSTSGENASGKYCGKTQTIFLKYPQEKNNG 814
           PQ+S+PDI IWM+   KR+AYAR+P+  +L+S   E  +GK C K +T+FLK P ++  G
Sbjct: 95  PQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIV-EEETGKDCAKVKTLFLKLPGKRGFG 153

Query: 815 P---KVPVELRVNIWLGLSAVEKKF 836
                V  ++ + +WLGLS   K+F
Sbjct: 154 SAGWTVQAKVELYLWLGLSKQRKEF 178



 Score = 41.6 bits (96), Expect = 0.008
 Identities = 24/78 (30%), Positives = 38/78 (48%), Gaps = 8/78 (10%)

Query: 389 ADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVV---NLQI-----KFPSVCEKIKL 440
           AD   L DPF  V F  +  CT ++ +   P W+Q++   NL++     +       I +
Sbjct: 228 ADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVI 287

Query: 441 TIYDWDRLTKNDVVGTTY 458
            IYD D + K D +G T+
Sbjct: 288 EIYDQDSMGKADFMGRTF 305



 Score = 37.7 bits (86), Expect = 0.12
 Identities = 19/75 (25%), Positives = 36/75 (48%), Gaps = 3/75 (4%)

Query: 389 ADKKNLVDPFVEVSFAGKKVCT--NIIEKNANPEWNQVVNLQIKFPSVCEKIKLTIYDWD 446
           AD     DP++ +      +    N I K  NP + +  +++  FP     + + +YDWD
Sbjct: 740 ADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPME-SMLTVAVYDWD 798

Query: 447 RLTKNDVVGTTYLHL 461
            +  +D++G T + L
Sbjct: 799 LVGTDDLIGETKIDL 813



 Score = 32.3 bits (72), Expect = 4.9
 Identities = 24/95 (25%), Positives = 46/95 (48%), Gaps = 3/95 (3%)

Query: 193 SNKPQDFQIRVRVIEGRQLSGNNIRPVVKVHVCGQTHRTRIKRGNNPFFDEL---FFYNV 249
           SN P +  +RV V+    L   +I      ++  +  +T I+   N    +L   F  + 
Sbjct: 719 SNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSF 778

Query: 250 NMTPSELMDEIISIRVYNSHSLRADCLMGEFKIDV 284
           ++  S  M+ ++++ VY+   +  D L+GE KID+
Sbjct: 779 DIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDL 813


>gi|238550198 synaptotagmin III [Homo sapiens]
          Length = 590

 Score = 62.0 bits (149), Expect = 6e-09
 Identities = 33/89 (37%), Positives = 54/89 (60%), Gaps = 7/89 (7%)

Query: 1544 IYIVRGLELQPQDNNGLCDPYIKITL---GKKVIEDRDHYIPNTLNPVFGRMYELSCYLP 1600
            + I++ L+L  +D+NG  DPY+KI L    KK  + + H    TLNPVF   ++ S  L 
Sbjct: 318  VRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVH--RKTLNPVFNETFQFSVPLA 375

Query: 1601 Q--EKDLKISVYDYDTFTRDEKVGETIID 1627
            +  ++ L  SVYD+D F+R + +G+ ++D
Sbjct: 376  ELAQRKLHFSVYDFDRFSRHDLIGQVVLD 404



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 80/336 (23%), Positives = 128/336 (38%), Gaps = 54/336 (16%)

Query: 1110 GANTPIVSCNFDRVYIY---HLRCYVYQARNLLALDKDSFSDPYAHICFLHRSK---TTE 1163
            G   P    +F   Y+Y    L   + QA +L A D + FSDPY  I  L   K    T+
Sbjct: 295  GTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTK 354

Query: 1164 IIHSTLNPTWDQTIIFDEVEIYGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVV 1223
            +   TLNP      +F+E   +  P   L    K+   ++D D+  + + +G+ +   ++
Sbjct: 355  VHRKTLNP------VFNETFQFSVPLAELAQ-RKLHFSVYDFDRFSRHDLIGQVVLDNLL 407

Query: 1224 KLNSEMDITPKLLWHPVMNGDKACGDVLVTAELILRGKDGSNLPILPPQRAPNLYMVPQG 1283
            +L  +    P  LW  ++ G     D+         G+   +L  LP             
Sbjct: 408  ELAEQPPDRP--LWRDIVEGGSEKADL---------GELNFSLCYLP------------- 443

Query: 1284 IRPVVQLTAIEILAWGLRNMKNFQMASITSP----SLVVECGGERVESVVIKNLKKTPNF 1339
                 +LT   I A    N+K   +   + P    SL+ E    +     IK     P +
Sbjct: 444  --TAGRLTVTIIKA---SNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTY 498

Query: 1340 PSSVLFMKVFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTIERLDRFRCDPYAGKEDIV 1399
              +++F    +  E +    L I V+D+   G   V+G C   R+     DP+ G+E   
Sbjct: 499  NEALVF---DVAPESVENVGLSIAVVDYDCIGHNEVIGVC---RVGPDAADPH-GREHWA 551

Query: 1400 PQLKASLLSAPPCRDIVIEMEDTKPLLASK-LTEKE 1434
              L            +V E   T     SK L+EKE
Sbjct: 552  EMLANPRKPVEHWHQLVEEKTVTSFTKGSKGLSEKE 587



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 43/184 (23%), Positives = 80/184 (43%), Gaps = 33/184 (17%)

Query: 390 DKKNLVDPFVEVSFAG---KKVCTNIIEKNANPEWNQVVNLQIKFPSVCE-KIKLTIYDW 445
           D     DP+V++       KK  T +  K  NP +N+     +    + + K+  ++YD+
Sbjct: 330 DSNGFSDPYVKIYLLPDRKKKFQTKVHRKTLNPVFNETFQFSVPLAELAQRKLHFSVYDF 389

Query: 446 DRLTKNDVVGTTYL-HLSKIA------------ASGGEVEVNTGETEVG--FVPTFGPCY 490
           DR +++D++G   L +L ++A              GG  + + GE      ++PT G   
Sbjct: 390 DRFSRHDLIGQVVLDNLLELAEQPPDRPLWRDIVEGGSEKADLGELNFSLCYLPTAGRLT 449

Query: 491 LNLYGSPR----EYTGFPDPYDELNTGKGEGVAYRGRILVELATFLEKTPPDKKLEPISN 546
           + +  +      + TGF DPY + +      +   GR L +  T ++K      L P  N
Sbjct: 450 VTIIKASNLKAMDLTGFSDPYVKAS------LISEGRRLKKRKTSIKK----NTLNPTYN 499

Query: 547 DDLL 550
           + L+
Sbjct: 500 EALV 503



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 32/91 (35%), Positives = 44/91 (48%), Gaps = 7/91 (7%)

Query: 2   LRVIVESASNIPKTKF-GKPDPIVSVIFKDE-----KKKTKKVDNELNPVWNEILEFDLR 55
           L V +  ASN+      G  DP V      E     K+KT    N LNP +NE L FD+ 
Sbjct: 448 LTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALVFDVA 507

Query: 56  GIPLDFSSSLGIIVKDFETIGQNKLIGTATV 86
              ++ +  L I V D++ IG N++IG   V
Sbjct: 508 PESVE-NVGLSIAVVDYDCIGHNEVIGVCRV 537



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 24/92 (26%), Positives = 47/92 (51%), Gaps = 5/92 (5%)

Query: 1536 VPQECTVRIYIVRGLELQPQDNNGLCDPYIKITL---GKKVIEDRDHYIPNTLNPVFGR- 1591
            +P    + + I++   L+  D  G  DPY+K +L   G+++ + +     NTLNP +   
Sbjct: 442  LPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEA 501

Query: 1592 -MYELSCYLPQEKDLKISVYDYDTFTRDEKVG 1622
             +++++    +   L I+V DYD    +E +G
Sbjct: 502  LVFDVAPESVENVGLSIAVVDYDCIGHNEVIG 533



 Score = 33.5 bits (75), Expect = 2.2
 Identities = 30/85 (35%), Positives = 41/85 (48%), Gaps = 5/85 (5%)

Query: 2   LRVIVESASNIP-KTKFGKPDPIVSV-IFKDEKKK--TKKVDNELNPVWNEILEFDLRGI 57
           L V +  A ++P K   G  DP V + +  D KKK  TK     LNPV+NE  +F +   
Sbjct: 316 LVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVHRKTLNPVFNETFQFSVPLA 375

Query: 58  PLDFSSSLGIIVKDFETIGQNKLIG 82
            L     L   V DF+   ++ LIG
Sbjct: 376 EL-AQRKLHFSVYDFDRFSRHDLIG 399


>gi|238550196 synaptotagmin III [Homo sapiens]
          Length = 590

 Score = 62.0 bits (149), Expect = 6e-09
 Identities = 33/89 (37%), Positives = 54/89 (60%), Gaps = 7/89 (7%)

Query: 1544 IYIVRGLELQPQDNNGLCDPYIKITL---GKKVIEDRDHYIPNTLNPVFGRMYELSCYLP 1600
            + I++ L+L  +D+NG  DPY+KI L    KK  + + H    TLNPVF   ++ S  L 
Sbjct: 318  VRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVH--RKTLNPVFNETFQFSVPLA 375

Query: 1601 Q--EKDLKISVYDYDTFTRDEKVGETIID 1627
            +  ++ L  SVYD+D F+R + +G+ ++D
Sbjct: 376  ELAQRKLHFSVYDFDRFSRHDLIGQVVLD 404



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 80/336 (23%), Positives = 128/336 (38%), Gaps = 54/336 (16%)

Query: 1110 GANTPIVSCNFDRVYIY---HLRCYVYQARNLLALDKDSFSDPYAHICFLHRSK---TTE 1163
            G   P    +F   Y+Y    L   + QA +L A D + FSDPY  I  L   K    T+
Sbjct: 295  GTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTK 354

Query: 1164 IIHSTLNPTWDQTIIFDEVEIYGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVV 1223
            +   TLNP      +F+E   +  P   L    K+   ++D D+  + + +G+ +   ++
Sbjct: 355  VHRKTLNP------VFNETFQFSVPLAELAQ-RKLHFSVYDFDRFSRHDLIGQVVLDNLL 407

Query: 1224 KLNSEMDITPKLLWHPVMNGDKACGDVLVTAELILRGKDGSNLPILPPQRAPNLYMVPQG 1283
            +L  +    P  LW  ++ G     D+         G+   +L  LP             
Sbjct: 408  ELAEQPPDRP--LWRDIVEGGSEKADL---------GELNFSLCYLP------------- 443

Query: 1284 IRPVVQLTAIEILAWGLRNMKNFQMASITSP----SLVVECGGERVESVVIKNLKKTPNF 1339
                 +LT   I A    N+K   +   + P    SL+ E    +     IK     P +
Sbjct: 444  --TAGRLTVTIIKA---SNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTY 498

Query: 1340 PSSVLFMKVFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTIERLDRFRCDPYAGKEDIV 1399
              +++F    +  E +    L I V+D+   G   V+G C   R+     DP+ G+E   
Sbjct: 499  NEALVF---DVAPESVENVGLSIAVVDYDCIGHNEVIGVC---RVGPDAADPH-GREHWA 551

Query: 1400 PQLKASLLSAPPCRDIVIEMEDTKPLLASK-LTEKE 1434
              L            +V E   T     SK L+EKE
Sbjct: 552  EMLANPRKPVEHWHQLVEEKTVTSFTKGSKGLSEKE 587



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 43/184 (23%), Positives = 80/184 (43%), Gaps = 33/184 (17%)

Query: 390 DKKNLVDPFVEVSFAG---KKVCTNIIEKNANPEWNQVVNLQIKFPSVCE-KIKLTIYDW 445
           D     DP+V++       KK  T +  K  NP +N+     +    + + K+  ++YD+
Sbjct: 330 DSNGFSDPYVKIYLLPDRKKKFQTKVHRKTLNPVFNETFQFSVPLAELAQRKLHFSVYDF 389

Query: 446 DRLTKNDVVGTTYL-HLSKIA------------ASGGEVEVNTGETEVG--FVPTFGPCY 490
           DR +++D++G   L +L ++A              GG  + + GE      ++PT G   
Sbjct: 390 DRFSRHDLIGQVVLDNLLELAEQPPDRPLWRDIVEGGSEKADLGELNFSLCYLPTAGRLT 449

Query: 491 LNLYGSPR----EYTGFPDPYDELNTGKGEGVAYRGRILVELATFLEKTPPDKKLEPISN 546
           + +  +      + TGF DPY + +      +   GR L +  T ++K      L P  N
Sbjct: 450 VTIIKASNLKAMDLTGFSDPYVKAS------LISEGRRLKKRKTSIKK----NTLNPTYN 499

Query: 547 DDLL 550
           + L+
Sbjct: 500 EALV 503



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 32/91 (35%), Positives = 44/91 (48%), Gaps = 7/91 (7%)

Query: 2   LRVIVESASNIPKTKF-GKPDPIVSVIFKDE-----KKKTKKVDNELNPVWNEILEFDLR 55
           L V +  ASN+      G  DP V      E     K+KT    N LNP +NE L FD+ 
Sbjct: 448 LTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALVFDVA 507

Query: 56  GIPLDFSSSLGIIVKDFETIGQNKLIGTATV 86
              ++ +  L I V D++ IG N++IG   V
Sbjct: 508 PESVE-NVGLSIAVVDYDCIGHNEVIGVCRV 537



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 24/92 (26%), Positives = 47/92 (51%), Gaps = 5/92 (5%)

Query: 1536 VPQECTVRIYIVRGLELQPQDNNGLCDPYIKITL---GKKVIEDRDHYIPNTLNPVFGR- 1591
            +P    + + I++   L+  D  G  DPY+K +L   G+++ + +     NTLNP +   
Sbjct: 442  LPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEA 501

Query: 1592 -MYELSCYLPQEKDLKISVYDYDTFTRDEKVG 1622
             +++++    +   L I+V DYD    +E +G
Sbjct: 502  LVFDVAPESVENVGLSIAVVDYDCIGHNEVIG 533



 Score = 33.5 bits (75), Expect = 2.2
 Identities = 30/85 (35%), Positives = 41/85 (48%), Gaps = 5/85 (5%)

Query: 2   LRVIVESASNIP-KTKFGKPDPIVSV-IFKDEKKK--TKKVDNELNPVWNEILEFDLRGI 57
           L V +  A ++P K   G  DP V + +  D KKK  TK     LNPV+NE  +F +   
Sbjct: 316 LVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVHRKTLNPVFNETFQFSVPLA 375

Query: 58  PLDFSSSLGIIVKDFETIGQNKLIG 82
            L     L   V DF+   ++ LIG
Sbjct: 376 EL-AQRKLHFSVYDFDRFSRHDLIG 399


>gi|14150054 synaptotagmin III [Homo sapiens]
          Length = 590

 Score = 62.0 bits (149), Expect = 6e-09
 Identities = 33/89 (37%), Positives = 54/89 (60%), Gaps = 7/89 (7%)

Query: 1544 IYIVRGLELQPQDNNGLCDPYIKITL---GKKVIEDRDHYIPNTLNPVFGRMYELSCYLP 1600
            + I++ L+L  +D+NG  DPY+KI L    KK  + + H    TLNPVF   ++ S  L 
Sbjct: 318  VRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVH--RKTLNPVFNETFQFSVPLA 375

Query: 1601 Q--EKDLKISVYDYDTFTRDEKVGETIID 1627
            +  ++ L  SVYD+D F+R + +G+ ++D
Sbjct: 376  ELAQRKLHFSVYDFDRFSRHDLIGQVVLD 404



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 80/336 (23%), Positives = 128/336 (38%), Gaps = 54/336 (16%)

Query: 1110 GANTPIVSCNFDRVYIY---HLRCYVYQARNLLALDKDSFSDPYAHICFLHRSK---TTE 1163
            G   P    +F   Y+Y    L   + QA +L A D + FSDPY  I  L   K    T+
Sbjct: 295  GTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTK 354

Query: 1164 IIHSTLNPTWDQTIIFDEVEIYGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVV 1223
            +   TLNP      +F+E   +  P   L    K+   ++D D+  + + +G+ +   ++
Sbjct: 355  VHRKTLNP------VFNETFQFSVPLAELAQ-RKLHFSVYDFDRFSRHDLIGQVVLDNLL 407

Query: 1224 KLNSEMDITPKLLWHPVMNGDKACGDVLVTAELILRGKDGSNLPILPPQRAPNLYMVPQG 1283
            +L  +    P  LW  ++ G     D+         G+   +L  LP             
Sbjct: 408  ELAEQPPDRP--LWRDIVEGGSEKADL---------GELNFSLCYLP------------- 443

Query: 1284 IRPVVQLTAIEILAWGLRNMKNFQMASITSP----SLVVECGGERVESVVIKNLKKTPNF 1339
                 +LT   I A    N+K   +   + P    SL+ E    +     IK     P +
Sbjct: 444  --TAGRLTVTIIKA---SNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTY 498

Query: 1340 PSSVLFMKVFLPKEELYMPPLVIKVIDHRQFGRKPVVGQCTIERLDRFRCDPYAGKEDIV 1399
              +++F    +  E +    L I V+D+   G   V+G C   R+     DP+ G+E   
Sbjct: 499  NEALVF---DVAPESVENVGLSIAVVDYDCIGHNEVIGVC---RVGPDAADPH-GREHWA 551

Query: 1400 PQLKASLLSAPPCRDIVIEMEDTKPLLASK-LTEKE 1434
              L            +V E   T     SK L+EKE
Sbjct: 552  EMLANPRKPVEHWHQLVEEKTVTSFTKGSKGLSEKE 587



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 43/184 (23%), Positives = 80/184 (43%), Gaps = 33/184 (17%)

Query: 390 DKKNLVDPFVEVSFAG---KKVCTNIIEKNANPEWNQVVNLQIKFPSVCE-KIKLTIYDW 445
           D     DP+V++       KK  T +  K  NP +N+     +    + + K+  ++YD+
Sbjct: 330 DSNGFSDPYVKIYLLPDRKKKFQTKVHRKTLNPVFNETFQFSVPLAELAQRKLHFSVYDF 389

Query: 446 DRLTKNDVVGTTYL-HLSKIA------------ASGGEVEVNTGETEVG--FVPTFGPCY 490
           DR +++D++G   L +L ++A              GG  + + GE      ++PT G   
Sbjct: 390 DRFSRHDLIGQVVLDNLLELAEQPPDRPLWRDIVEGGSEKADLGELNFSLCYLPTAGRLT 449

Query: 491 LNLYGSPR----EYTGFPDPYDELNTGKGEGVAYRGRILVELATFLEKTPPDKKLEPISN 546
           + +  +      + TGF DPY + +      +   GR L +  T ++K      L P  N
Sbjct: 450 VTIIKASNLKAMDLTGFSDPYVKAS------LISEGRRLKKRKTSIKK----NTLNPTYN 499

Query: 547 DDLL 550
           + L+
Sbjct: 500 EALV 503



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 32/91 (35%), Positives = 44/91 (48%), Gaps = 7/91 (7%)

Query: 2   LRVIVESASNIPKTKF-GKPDPIVSVIFKDE-----KKKTKKVDNELNPVWNEILEFDLR 55
           L V +  ASN+      G  DP V      E     K+KT    N LNP +NE L FD+ 
Sbjct: 448 LTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALVFDVA 507

Query: 56  GIPLDFSSSLGIIVKDFETIGQNKLIGTATV 86
              ++ +  L I V D++ IG N++IG   V
Sbjct: 508 PESVE-NVGLSIAVVDYDCIGHNEVIGVCRV 537



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 24/92 (26%), Positives = 47/92 (51%), Gaps = 5/92 (5%)

Query: 1536 VPQECTVRIYIVRGLELQPQDNNGLCDPYIKITL---GKKVIEDRDHYIPNTLNPVFGR- 1591
            +P    + + I++   L+  D  G  DPY+K +L   G+++ + +     NTLNP +   
Sbjct: 442  LPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEA 501

Query: 1592 -MYELSCYLPQEKDLKISVYDYDTFTRDEKVG 1622
             +++++    +   L I+V DYD    +E +G
Sbjct: 502  LVFDVAPESVENVGLSIAVVDYDCIGHNEVIG 533



 Score = 33.5 bits (75), Expect = 2.2
 Identities = 30/85 (35%), Positives = 41/85 (48%), Gaps = 5/85 (5%)

Query: 2   LRVIVESASNIP-KTKFGKPDPIVSV-IFKDEKKK--TKKVDNELNPVWNEILEFDLRGI 57
           L V +  A ++P K   G  DP V + +  D KKK  TK     LNPV+NE  +F +   
Sbjct: 316 LVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVHRKTLNPVFNETFQFSVPLA 375

Query: 58  PLDFSSSLGIIVKDFETIGQNKLIG 82
            L     L   V DF+   ++ LIG
Sbjct: 376 EL-AQRKLHFSVYDFDRFSRHDLIG 399


>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
          Length = 1670

 Score = 59.7 bits (143), Expect = 3e-08
 Identities = 44/124 (35%), Positives = 61/124 (49%), Gaps = 14/124 (11%)

Query: 1125 IYHLRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTWDQTIIFDEVEI 1184
            I  L  +V +A  L A   +  S+PY  I    +S TT  I  TLNP W+    F   ++
Sbjct: 1541 IGRLMVHVIEATELKACKPNGKSNPYCEISMGSQSYTTRTIQDTLNPKWNFNCQFFIKDL 1600

Query: 1185 YGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVVKLNSEMD----ITPKLLWHPV 1240
            Y   Q VL       + LFD DQ   D+FLGR+   PV K+ +E +    +T +LL H V
Sbjct: 1601 Y---QDVL------CLTLFDRDQFSPDDFLGRTEI-PVAKIRTEQESKGPMTRRLLLHEV 1650

Query: 1241 MNGD 1244
              G+
Sbjct: 1651 PTGE 1654



 Score = 40.8 bits (94), Expect = 0.014
 Identities = 29/98 (29%), Positives = 48/98 (48%), Gaps = 13/98 (13%)

Query: 396  DPFVEVSFAGKKVCTNIIEKNANPEWNQVVNLQIKFPSVCEKIK-LTIYDWDRLTKNDVV 454
            +P+ E+S   +   T  I+   NP+WN   N Q     + + +  LT++D D+ + +D +
Sbjct: 1564 NPYCEISMGSQSYTTRTIQDTLNPKWN--FNCQFFIKDLYQDVLCLTLFDRDQFSPDDFL 1621

Query: 455  GTTYLHLSKIAA---SGGEV-------EVNTGETEVGF 482
            G T + ++KI     S G +       EV TGE  V F
Sbjct: 1622 GRTEIPVAKIRTEQESKGPMTRRLLLHEVPTGEVWVRF 1659


>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
          Length = 1697

 Score = 59.7 bits (143), Expect = 3e-08
 Identities = 44/124 (35%), Positives = 61/124 (49%), Gaps = 14/124 (11%)

Query: 1125 IYHLRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTWDQTIIFDEVEI 1184
            I  L  +V +A  L A   +  S+PY  I    +S TT  I  TLNP W+    F   ++
Sbjct: 1568 IGRLMVHVIEATELKACKPNGKSNPYCEISMGSQSYTTRTIQDTLNPKWNFNCQFFIKDL 1627

Query: 1185 YGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFSPVVKLNSEMD----ITPKLLWHPV 1240
            Y   Q VL       + LFD DQ   D+FLGR+   PV K+ +E +    +T +LL H V
Sbjct: 1628 Y---QDVL------CLTLFDRDQFSPDDFLGRTEI-PVAKIRTEQESKGPMTRRLLLHEV 1677

Query: 1241 MNGD 1244
              G+
Sbjct: 1678 PTGE 1681



 Score = 40.8 bits (94), Expect = 0.014
 Identities = 29/98 (29%), Positives = 48/98 (48%), Gaps = 13/98 (13%)

Query: 396  DPFVEVSFAGKKVCTNIIEKNANPEWNQVVNLQIKFPSVCEKIK-LTIYDWDRLTKNDVV 454
            +P+ E+S   +   T  I+   NP+WN   N Q     + + +  LT++D D+ + +D +
Sbjct: 1591 NPYCEISMGSQSYTTRTIQDTLNPKWN--FNCQFFIKDLYQDVLCLTLFDRDQFSPDDFL 1648

Query: 455  GTTYLHLSKIAA---SGGEV-------EVNTGETEVGF 482
            G T + ++KI     S G +       EV TGE  V F
Sbjct: 1649 GRTEIPVAKIRTEQESKGPMTRRLLLHEVPTGEVWVRF 1686


>gi|50582996 multiple C2 domains, transmembrane 1 isoform S [Homo
            sapiens]
          Length = 778

 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 32/98 (32%), Positives = 53/98 (54%), Gaps = 4/98 (4%)

Query: 1542 VRIYIVRGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLPQ 1601
            V I ++ G +L+  D+NGL DPY+K  LG +  + +   +P TLNP +   ++   Y  +
Sbjct: 251  VSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSK--IMPKTLNPQWREQFDFHLYEER 308

Query: 1602 EKDLKISVYDYDTFTRDEKVGETIIDLENRFLSRFGSH 1639
               + I+ +D D   RD+ +G   +DL    LSR  +H
Sbjct: 309  GGVIDITAWDKDAGKRDDFIGRCQVDLS--ALSREQTH 344



 Score = 52.4 bits (124), Expect = 5e-06
 Identities = 71/307 (23%), Positives = 127/307 (41%), Gaps = 51/307 (16%)

Query: 201 IRVRVIEGRQLSGNNIR----PVVKVHVCGQTHRTRIK-RGNNPFFDELFFYNVNMTPSE 255
           + + +IEGR L   +      P VK  +  Q ++++I  +  NP + E F +++     E
Sbjct: 251 VSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHLY----E 306

Query: 256 LMDEIISIRVYNSHSLRADCLMGEFKIDVGFVYDEPGHAVMRKWLLLNDPED-------- 307
               +I I  ++  + + D  +G  ++D+  +  E  H +    L L + E         
Sbjct: 307 ERGGVIDITAWDKDAGKRDDFIGRCQVDLSALSREQTHKLE---LQLEEGEGHLVLLVTL 363

Query: 308 TSSGSKGYMKVSMFVLGTGDEPPPERRDRDNDSDDVESNLLLPAGIALRWVTFL-LKIYR 366
           T+S +     +S+  L           D+    + ++    L     L+ V FL +K+ R
Sbjct: 364 TASATVSISDLSVNSL----------EDQKEREEILKRYSPLRIFHNLKDVGFLQVKVIR 413

Query: 367 AEDIPQMDDAFSQTVKEIFGGNADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVVN 426
           AE +                  AD     DPF  V     ++ T+ + KN NPEWN+V  
Sbjct: 414 AEGLMA----------------ADVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFT 457

Query: 427 LQIKFPSVCEKIKLTIYDWDRLTKNDVVGTTYLHLSKIAASGGEVEVNTGETEVGFVPTF 486
             IK   +   +++T+YD DR    D +G   + L  ++   GE +    + +    PT 
Sbjct: 458 FNIK--DIHSVLEVTVYDEDRDRSADFLGKVAIPL--LSIQNGEQKAYVLKNKQLTGPTK 513

Query: 487 GPCYLNL 493
           G  YL +
Sbjct: 514 GVIYLEI 520



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 36/107 (33%), Positives = 53/107 (49%), Gaps = 6/107 (5%)

Query: 1531 ELPDSVPQECTVRIYIVRGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFG 1590
            E+P + P    + I + RG  L  +D  G  DPY+K  +G K +  R   I   LNPV+ 
Sbjct: 31   EVPLADPGMYQLDITLRRGQSLAARDRGGTSDPYVKFKIGGKEV-FRSKIIHKNLNPVW- 88

Query: 1591 RMYELSCYLPQ--EKDLKISVYDYDTFTRDEKVGETIIDLENRFLSR 1635
               E +C L     + L I V+DYD   +D+ +G   +DL    L+R
Sbjct: 89   --EEKACILVDHLREPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNR 133



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 25/83 (30%), Positives = 41/83 (49%), Gaps = 9/83 (10%)

Query: 1134 QARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTWDQTIIFDEVEIYGEPQTVLQ 1193
            + R+L A+D +  SDPY      H+   ++I+  TLNP W +   F    +Y E   V+ 
Sbjct: 257  EGRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDF---HLYEERGGVID 313

Query: 1194 NPPKVIMELFDNDQVGKDEFLGR 1216
                  +  +D D   +D+F+GR
Sbjct: 314  ------ITAWDKDAGKRDDFIGR 330



 Score = 41.2 bits (95), Expect = 0.011
 Identities = 21/76 (27%), Positives = 43/76 (56%), Gaps = 3/76 (3%)

Query: 390 DKKNLVDPFVEVSFAGKKVC-TNIIEKNANPEWNQVVNLQIKFPSVCEKIKLTIYDWDRL 448
           D+    DP+V+    GK+V  + II KN NP W +   + +    + E + + ++D+D  
Sbjct: 56  DRGGTSDPYVKFKIGGKEVFRSKIIHKNLNPVWEEKACILV--DHLREPLYIKVFDYDFG 113

Query: 449 TKNDVVGTTYLHLSKI 464
            ++D +G+ +L L+++
Sbjct: 114 LQDDFMGSAFLDLTQL 129



 Score = 38.5 bits (88), Expect = 0.068
 Identities = 33/115 (28%), Positives = 55/115 (47%), Gaps = 22/115 (19%)

Query: 1125 IYHLRCYVYQARNLLALDKDSFSDPYAHICF----LHRSKTTEIIHSTLNPTWDQ--TII 1178
            +Y L   + + ++L A D+   SDPY         + RSK   IIH  LNP W++   I+
Sbjct: 39   MYQLDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSK---IIHKNLNPVWEEKACIL 95

Query: 1179 FDEVEIYGEPQTVLQNPPKVIMELFDNDQVGKDEFLGRSIFS-PVVKLNSEMDIT 1232
             D +    EP         + +++FD D   +D+F+G +      ++LN   D+T
Sbjct: 96   VDHLR---EP---------LYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVT 138



 Score = 36.6 bits (83), Expect = 0.26
 Identities = 23/89 (25%), Positives = 44/89 (49%), Gaps = 10/89 (11%)

Query: 1128 LRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTWDQTIIFDEVEIYGE 1187
            L+  V +A  L+A D    SDP+  +   +    T  ++  LNP W++   F+  +I+  
Sbjct: 407  LQVKVIRAEGLMAADVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKDIH-- 464

Query: 1188 PQTVLQNPPKVIMELFDNDQVGKDEFLGR 1216
              +VL+      + ++D D+    +FLG+
Sbjct: 465  --SVLE------VTVYDEDRDRSADFLGK 485



 Score = 36.6 bits (83), Expect = 0.26
 Identities = 21/85 (24%), Positives = 37/85 (43%), Gaps = 4/85 (4%)

Query: 18  GKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLDFSSSLGIIVKDFETIGQ 77
           GK DP   V   +++  T  V   LNP WN++  F+++    D  S L + V D +    
Sbjct: 424 GKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIK----DIHSVLEVTVYDEDRDRS 479

Query: 78  NKLIGTATVALKDLTGDQSRSLPYK 102
              +G   + L  +   + ++   K
Sbjct: 480 ADFLGKVAIPLLSIQNGEQKAYVLK 504



 Score = 33.5 bits (75), Expect = 2.2
 Identities = 27/89 (30%), Positives = 39/89 (43%), Gaps = 9/89 (10%)

Query: 18  GKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDL---RGIPLDFSSSLGIIVKDFET 74
           G  DP V      +K K+K +   LNP W E  +F L   RG  +D      I   D + 
Sbjct: 268 GLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHLYEERGGVID------ITAWDKDA 321

Query: 75  IGQNKLIGTATVALKDLTGDQSRSLPYKL 103
             ++  IG   V L  L+ +Q+  L  +L
Sbjct: 322 GKRDDFIGRCQVDLSALSREQTHKLELQL 350


>gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Homo
            sapiens]
          Length = 999

 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 32/98 (32%), Positives = 53/98 (54%), Gaps = 4/98 (4%)

Query: 1542 VRIYIVRGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFGRMYELSCYLPQ 1601
            V I ++ G +L+  D+NGL DPY+K  LG +  + +   +P TLNP +   ++   Y  +
Sbjct: 472  VSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSK--IMPKTLNPQWREQFDFHLYEER 529

Query: 1602 EKDLKISVYDYDTFTRDEKVGETIIDLENRFLSRFGSH 1639
               + I+ +D D   RD+ +G   +DL    LSR  +H
Sbjct: 530  GGVIDITAWDKDAGKRDDFIGRCQVDLS--ALSREQTH 565



 Score = 52.4 bits (124), Expect = 5e-06
 Identities = 71/307 (23%), Positives = 127/307 (41%), Gaps = 51/307 (16%)

Query: 201 IRVRVIEGRQLSGNNIR----PVVKVHVCGQTHRTRIK-RGNNPFFDELFFYNVNMTPSE 255
           + + +IEGR L   +      P VK  +  Q ++++I  +  NP + E F +++     E
Sbjct: 472 VSITLIEGRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHLY----E 527

Query: 256 LMDEIISIRVYNSHSLRADCLMGEFKIDVGFVYDEPGHAVMRKWLLLNDPED-------- 307
               +I I  ++  + + D  +G  ++D+  +  E  H +    L L + E         
Sbjct: 528 ERGGVIDITAWDKDAGKRDDFIGRCQVDLSALSREQTHKLE---LQLEEGEGHLVLLVTL 584

Query: 308 TSSGSKGYMKVSMFVLGTGDEPPPERRDRDNDSDDVESNLLLPAGIALRWVTFL-LKIYR 366
           T+S +     +S+  L           D+    + ++    L     L+ V FL +K+ R
Sbjct: 585 TASATVSISDLSVNSL----------EDQKEREEILKRYSPLRIFHNLKDVGFLQVKVIR 634

Query: 367 AEDIPQMDDAFSQTVKEIFGGNADKKNLVDPFVEVSFAGKKVCTNIIEKNANPEWNQVVN 426
           AE +                  AD     DPF  V     ++ T+ + KN NPEWN+V  
Sbjct: 635 AEGLMA----------------ADVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFT 678

Query: 427 LQIKFPSVCEKIKLTIYDWDRLTKNDVVGTTYLHLSKIAASGGEVEVNTGETEVGFVPTF 486
             IK   +   +++T+YD DR    D +G   + L  ++   GE +    + +    PT 
Sbjct: 679 FNIK--DIHSVLEVTVYDEDRDRSADFLGKVAIPL--LSIQNGEQKAYVLKNKQLTGPTK 734

Query: 487 GPCYLNL 493
           G  YL +
Sbjct: 735 GVIYLEI 741



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 36/107 (33%), Positives = 53/107 (49%), Gaps = 6/107 (5%)

Query: 1531 ELPDSVPQECTVRIYIVRGLELQPQDNNGLCDPYIKITLGKKVIEDRDHYIPNTLNPVFG 1590
            E+P + P    + I + RG  L  +D  G  DPY+K  +G K +  R   I   LNPV+ 
Sbjct: 252  EVPLADPGMYQLDITLRRGQSLAARDRGGTSDPYVKFKIGGKEV-FRSKIIHKNLNPVW- 309

Query: 1591 RMYELSCYLPQ--EKDLKISVYDYDTFTRDEKVGETIIDLENRFLSR 1635
               E +C L     + L I V+DYD   +D+ +G   +DL    L+R
Sbjct: 310  --EEKACILVDHLREPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNR 354



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 25/83 (30%), Positives = 41/83 (49%), Gaps = 9/83 (10%)

Query: 1134 QARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTWDQTIIFDEVEIYGEPQTVLQ 1193
            + R+L A+D +  SDPY      H+   ++I+  TLNP W +   F    +Y E   V+ 
Sbjct: 478  EGRDLKAMDSNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDF---HLYEERGGVID 534

Query: 1194 NPPKVIMELFDNDQVGKDEFLGR 1216
                  +  +D D   +D+F+GR
Sbjct: 535  ------ITAWDKDAGKRDDFIGR 551



 Score = 41.2 bits (95), Expect = 0.011
 Identities = 21/76 (27%), Positives = 43/76 (56%), Gaps = 3/76 (3%)

Query: 390 DKKNLVDPFVEVSFAGKKVC-TNIIEKNANPEWNQVVNLQIKFPSVCEKIKLTIYDWDRL 448
           D+    DP+V+    GK+V  + II KN NP W +   + +    + E + + ++D+D  
Sbjct: 277 DRGGTSDPYVKFKIGGKEVFRSKIIHKNLNPVWEEKACILV--DHLREPLYIKVFDYDFG 334

Query: 449 TKNDVVGTTYLHLSKI 464
            ++D +G+ +L L+++
Sbjct: 335 LQDDFMGSAFLDLTQL 350



 Score = 38.9 bits (89), Expect = 0.052
 Identities = 38/149 (25%), Positives = 65/149 (43%), Gaps = 27/149 (18%)

Query: 1091 EDGDEKSLEKQKHSATTVFGANTPIVSCNFDRVYIYHLRCYVYQARNLLALDKDSFSDPY 1150
            E G+E    ++  +      A  P+         +Y L   + + ++L A D+   SDPY
Sbjct: 231  ETGEEHGSSQKIINTAGTSNAEVPLADPG-----MYQLDITLRRGQSLAARDRGGTSDPY 285

Query: 1151 AHICF----LHRSKTTEIIHSTLNPTWDQ--TIIFDEVEIYGEPQTVLQNPPKVIMELFD 1204
                     + RSK   IIH  LNP W++   I+ D +    EP         + +++FD
Sbjct: 286  VKFKIGGKEVFRSK---IIHKNLNPVWEEKACILVDHLR---EP---------LYIKVFD 330

Query: 1205 NDQVGKDEFLGRSIFS-PVVKLNSEMDIT 1232
             D   +D+F+G +      ++LN   D+T
Sbjct: 331  YDFGLQDDFMGSAFLDLTQLELNRPTDVT 359



 Score = 36.6 bits (83), Expect = 0.26
 Identities = 23/89 (25%), Positives = 44/89 (49%), Gaps = 10/89 (11%)

Query: 1128 LRCYVYQARNLLALDKDSFSDPYAHICFLHRSKTTEIIHSTLNPTWDQTIIFDEVEIYGE 1187
            L+  V +A  L+A D    SDP+  +   +    T  ++  LNP W++   F+  +I+  
Sbjct: 628  LQVKVIRAEGLMAADVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKDIH-- 685

Query: 1188 PQTVLQNPPKVIMELFDNDQVGKDEFLGR 1216
              +VL+      + ++D D+    +FLG+
Sbjct: 686  --SVLE------VTVYDEDRDRSADFLGK 706



 Score = 36.6 bits (83), Expect = 0.26
 Identities = 21/85 (24%), Positives = 37/85 (43%), Gaps = 4/85 (4%)

Query: 18  GKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDLRGIPLDFSSSLGIIVKDFETIGQ 77
           GK DP   V   +++  T  V   LNP WN++  F+++    D  S L + V D +    
Sbjct: 645 GKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIK----DIHSVLEVTVYDEDRDRS 700

Query: 78  NKLIGTATVALKDLTGDQSRSLPYK 102
              +G   + L  +   + ++   K
Sbjct: 701 ADFLGKVAIPLLSIQNGEQKAYVLK 725



 Score = 33.5 bits (75), Expect = 2.2
 Identities = 27/89 (30%), Positives = 39/89 (43%), Gaps = 9/89 (10%)

Query: 18  GKPDPIVSVIFKDEKKKTKKVDNELNPVWNEILEFDL---RGIPLDFSSSLGIIVKDFET 74
           G  DP V      +K K+K +   LNP W E  +F L   RG  +D      I   D + 
Sbjct: 489 GLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHLYEERGGVID------ITAWDKDA 542

Query: 75  IGQNKLIGTATVALKDLTGDQSRSLPYKL 103
             ++  IG   V L  L+ +Q+  L  +L
Sbjct: 543 GKRDDFIGRCQVDLSALSREQTHKLELQL 571


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.137    0.418 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 85,131,091
Number of Sequences: 37866
Number of extensions: 4232193
Number of successful extensions: 12685
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 65
Number of HSP's successfully gapped in prelim test: 102
Number of HSP's that attempted gapping in prelim test: 11188
Number of HSP's gapped (non-prelim): 980
length of query: 2048
length of database: 18,247,518
effective HSP length: 118
effective length of query: 1930
effective length of database: 13,779,330
effective search space: 26594106900
effective search space used: 26594106900
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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