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Search of human proteins with 195220720
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|195220720 RUN and FYVE domain containing 3 isoform 3 [Homo
sapiens]
(506 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|195220720 RUN and FYVE domain containing 3 isoform 3 [Homo sa... 1004 0.0
gi|82697315 RUN and FYVE domain containing 3 isoform 1 [Homo sap... 746 0.0
gi|7662352 RUN and FYVE domain containing 3 isoform 2 [Homo sapi... 744 0.0
gi|109240556 RUN and FYVE domain-containing 2 isoform a [Homo sa... 487 e-138
gi|94721336 RUN and FYVE domain-containing 1 isoform a [Homo sap... 471 e-133
gi|94721330 RUN and FYVE domain-containing 1 isoform b [Homo sap... 465 e-131
gi|94721332 RUN and FYVE domain-containing 1 isoform b [Homo sap... 465 e-131
gi|109240552 RUN and FYVE domain-containing 2 isoform b [Homo sa... 419 e-117
gi|197304746 RUN domain containing 3B isoform c [Homo sapiens] 125 9e-29
gi|197304744 RUN domain containing 3B isoform b [Homo sapiens] 123 3e-28
gi|221307580 RUN domain containing 3A isoform 3 [Homo sapiens] 113 4e-25
gi|19923090 RUN domain containing 3B isoform a [Homo sapiens] 112 6e-25
gi|221307578 RUN domain containing 3A isoform 1 [Homo sapiens] 108 9e-24
gi|5730015 RUN domain containing 3A isoform 2 [Homo sapiens] 108 9e-24
gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapi... 70 5e-12
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 61 2e-09
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 59 1e-08
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 59 1e-08
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 59 1e-08
gi|40538728 pleckstrin homology domain containing, family M (wit... 58 2e-08
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 58 2e-08
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 57 4e-08
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 56 9e-08
gi|156104908 myosin heavy chain 6 [Homo sapiens] 55 1e-07
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 55 2e-07
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 54 3e-07
gi|27436951 lamin B2 [Homo sapiens] 53 6e-07
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 53 7e-07
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 53 7e-07
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 52 1e-06
>gi|195220720 RUN and FYVE domain containing 3 isoform 3 [Homo
sapiens]
Length = 506
Score = 1004 bits (2595), Expect = 0.0
Identities = 506/506 (100%), Positives = 506/506 (100%)
Query: 1 MAETPPPPTAGAESCSEEPARGGEWRPEEPRRAPAGGTDREGEAGPPPASPAGQSEPDSP 60
MAETPPPPTAGAESCSEEPARGGEWRPEEPRRAPAGGTDREGEAGPPPASPAGQSEPDSP
Sbjct: 1 MAETPPPPTAGAESCSEEPARGGEWRPEEPRRAPAGGTDREGEAGPPPASPAGQSEPDSP 60
Query: 61 VAAPFFLLYPGDGGAGFGVRPPPQQQRSWRTPPSPGSPLPFLLLSYPSGGGGSSGSGKHH 120
VAAPFFLLYPGDGGAGFGVRPPPQQQRSWRTPPSPGSPLPFLLLSYPSGGGGSSGSGKHH
Sbjct: 61 VAAPFFLLYPGDGGAGFGVRPPPQQQRSWRTPPSPGSPLPFLLLSYPSGGGGSSGSGKHH 120
Query: 121 PNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKK 180
PNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKK
Sbjct: 121 PNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKK 180
Query: 181 TFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYM 240
TFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYM
Sbjct: 181 TFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYM 240
Query: 241 KALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSM 300
KALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSM
Sbjct: 241 KALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSM 300
Query: 301 YLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELA 360
YLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELA
Sbjct: 301 YLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELA 360
Query: 361 VANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVE 420
VANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVE
Sbjct: 361 VANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVE 420
Query: 421 KELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVK 480
KELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVK
Sbjct: 421 KELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVK 480
Query: 481 QKSELNSRLEEKTNQMAATIKQLEQR 506
QKSELNSRLEEKTNQMAATIKQLEQR
Sbjct: 481 QKSELNSRLEEKTNQMAATIKQLEQR 506
>gi|82697315 RUN and FYVE domain containing 3 isoform 1 [Homo
sapiens]
Length = 620
Score = 746 bits (1925), Expect = 0.0
Identities = 386/386 (100%), Positives = 386/386 (100%)
Query: 121 PNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKK 180
PNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKK
Sbjct: 61 PNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKK 120
Query: 181 TFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYM 240
TFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYM
Sbjct: 121 TFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYM 180
Query: 241 KALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSM 300
KALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSM
Sbjct: 181 KALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSM 240
Query: 301 YLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELA 360
YLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELA
Sbjct: 241 YLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELA 300
Query: 361 VANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVE 420
VANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVE
Sbjct: 301 VANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVE 360
Query: 421 KELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVK 480
KELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVK
Sbjct: 361 KELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVK 420
Query: 481 QKSELNSRLEEKTNQMAATIKQLEQR 506
QKSELNSRLEEKTNQMAATIKQLEQR
Sbjct: 421 QKSELNSRLEEKTNQMAATIKQLEQR 446
Score = 32.0 bits (71), Expect = 1.4
Identities = 40/193 (20%), Positives = 88/193 (45%), Gaps = 7/193 (3%)
Query: 273 VGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELNR 332
+ + +++ + C K + L S +D LK + K D + + + +EE
Sbjct: 375 LAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTN 434
Query: 333 HLNATVNNLQAKVDALEKS--NTKLTEELAVAN--NRIITLQEEMERVKEESSYILESNR 388
+ AT+ L+ ++ E+S + +L L + ++I +LQ E+E + + + LE
Sbjct: 435 QMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVEELTRQRNQ-LELEL 493
Query: 389 KGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQ 448
K K+ R +++ R K E+++ K E + +++ +E + ++ + E+
Sbjct: 494 KQEKERRLQNDRSI-PGRGSQKSESKMD-GKHKMQEENVKLKKPLEESHRLQPHPMDEQD 551
Query: 449 DALVSLRQQLDDL 461
L+S + QL L
Sbjct: 552 QLLLSEKPQLCQL 564
>gi|7662352 RUN and FYVE domain containing 3 isoform 2 [Homo
sapiens]
Length = 469
Score = 744 bits (1920), Expect = 0.0
Identities = 385/385 (100%), Positives = 385/385 (100%)
Query: 121 PNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKK 180
PNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKK
Sbjct: 61 PNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKK 120
Query: 181 TFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYM 240
TFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYM
Sbjct: 121 TFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYM 180
Query: 241 KALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSM 300
KALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSM
Sbjct: 181 KALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSM 240
Query: 301 YLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELA 360
YLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELA
Sbjct: 241 YLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELA 300
Query: 361 VANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVE 420
VANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVE
Sbjct: 301 VANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVE 360
Query: 421 KELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVK 480
KELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVK
Sbjct: 361 KELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVK 420
Query: 481 QKSELNSRLEEKTNQMAATIKQLEQ 505
QKSELNSRLEEKTNQMAATIKQLEQ
Sbjct: 421 QKSELNSRLEEKTNQMAATIKQLEQ 445
>gi|109240556 RUN and FYVE domain-containing 2 isoform a [Homo
sapiens]
Length = 641
Score = 487 bits (1254), Expect = e-138
Identities = 252/395 (63%), Positives = 314/395 (79%), Gaps = 14/395 (3%)
Query: 126 ANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQ 185
A ER NL+NMAKLSIKGLIESAL+ GRTLDSDY PLQQFFVVMEHCLKHGLK +K+FL
Sbjct: 43 AVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKVRKSFLSY 102
Query: 186 NKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALIN 245
NK+ WGPLELVEKL PEA EI ASV+DLPGLKTP+GR RAWLRLALMQKK+++Y++ LI
Sbjct: 103 NKTIWGPLELVEKLYPEAEEIGASVRDLPGLKTPLGRARAWLRLALMQKKMADYLRCLII 162
Query: 246 KKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDG 305
+++LLSEFYE +ALMMEEEGA+I GLLVGLNVIDAN C+KGEDLDSQVGVIDFSMYLK+
Sbjct: 163 QRDLLSEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQVGVIDFSMYLKNE 222
Query: 306 NSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNR 365
E + QI AILDQKNYVEELNR LN+TV++L ++VD+LEKSNTKL EELA+A N
Sbjct: 223 EDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNN 282
Query: 366 IITLQEEMERVKEESSYIL--------------ESNRKGPKQDRTAEGQALSEARKHLKE 411
II LQEE +++ E+ IL E+ + K R + +EAR+ L++
Sbjct: 283 IIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRD 342
Query: 412 ETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFK 471
E+QLR DVE EL +Q+SM+ E+ELAMK+LEKD+ EKQD L+ LRQQL++++A+ E+ K
Sbjct: 343 ESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQK 402
Query: 472 LQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQR 506
LQ S+ G+K+K+E+ +RLEEKTN++ A ++QLEQR
Sbjct: 403 LQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQR 437
Score = 42.4 bits (98), Expect = 0.001
Identities = 50/206 (24%), Positives = 92/206 (44%), Gaps = 35/206 (16%)
Query: 292 QVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKS 351
+V I+ MY K S G + +I A L++K + A + L+ ++ EK+
Sbjct: 391 EVKAINIEMYQKLQGSEDGLKEKNEIIARLEEKT------NKITAAMRQLEQRLQQAEKA 444
Query: 352 NTKLTEE----LAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALS---E 404
+ +E L ++ +LQ+++ + KE+ LE++ K K+ R + L +
Sbjct: 445 QMEAEDEDEKYLQECLSKSDSLQKQISQ-KEKQLVQLETDLKIEKEWRQTLQEDLQKEKD 503
Query: 405 ARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRAL 464
A HL+ ETQ + ++KE ++++ E + L+K E++ AL
Sbjct: 504 ALSHLRNETQQIISLKKEF---LNLQDENQ----QLKKIYHEQEQAL------------- 543
Query: 465 KHELAFKLQSSDLGVKQKSELNSRLE 490
EL KL S L ++ E N L+
Sbjct: 544 -QELGNKLSESKLKIEDIKEANKALQ 568
>gi|94721336 RUN and FYVE domain-containing 1 isoform a [Homo
sapiens]
Length = 708
Score = 471 bits (1213), Expect = e-133
Identities = 263/499 (52%), Positives = 338/499 (67%), Gaps = 28/499 (5%)
Query: 33 APAGGTDREGEAGPPPASPAGQSEPDSPVAAPFFLLYPGDGGAGFGVRPPPQQQRSWRTP 92
A G + E E P P P EP PG G RP + W P
Sbjct: 9 AAGRGRELEPELEPGPG-PGSALEPGEEFEIVDRSQLPGPGDLRSATRP--RAAEGWSAP 65
Query: 93 PSPGSPLPFLLLSYPSG---------GGGSSGSG--KHHPNYLMANERMNLMNMAKLSIK 141
+ LS G GGG SG G + M ER NLM+M KLSIK
Sbjct: 66 ILTLARRATGNLSASCGSALRAAAGLGGGDSGDGTARAASKCQMMEERANLMHMMKLSIK 125
Query: 142 GLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVP 201
L++SAL+LGR+LD+D+APLQQFFVVMEHCLKHGLK KK+F+GQNKSF+GPLELVEKL P
Sbjct: 126 VLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKSFIGQNKSFFGPLELVEKLCP 185
Query: 202 EAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALINKKELLSEFYEPNALMM 261
EA++I SV++LP LKT VGRGRAWL LALMQKKL++Y+K LI+ K LLSEFYEP ALMM
Sbjct: 186 EASDIATSVRNLPELKTAVGRGRAWLYLALMQKKLADYLKVLIDNKHLLSEFYEPEALMM 245
Query: 262 EEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAIL 321
EEEG +I GLLVGLNV+DAN C+KGEDLDSQVGVIDFS+YLKD G + +IT +L
Sbjct: 246 EEEGMVIVGLLVGLNVLDANLCLKGEDLDSQVGVIDFSLYLKDVQDLDGGKEHERITDVL 305
Query: 322 DQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESS 381
DQKNYVEELNRHL+ TV +LQ K+D LEK+N+KL EEL+ A +RI +LQEE ++++E++
Sbjct: 306 DQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQNE 365
Query: 382 YILESNRKG---PKQDRTAEGQALSEAR-----------KHLKEETQLRLDVEKELEMQI 427
I E + K KQD E + + R K LKEE ++RL++EKELE+QI
Sbjct: 366 LIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKELELQI 425
Query: 428 SMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNS 487
M+ EME+AMK+LEKD EKQD LV+LRQQL++++A+ ++ K Q+++ ++QK+E +
Sbjct: 426 GMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAIT 485
Query: 488 RLEEKTNQMAATIKQLEQR 506
E KTNQ+ +++KQ+E+R
Sbjct: 486 SFEGKTNQVMSSMKQMEER 504
>gi|94721330 RUN and FYVE domain-containing 1 isoform b [Homo
sapiens]
Length = 600
Score = 465 bits (1196), Expect = e-131
Identities = 238/396 (60%), Positives = 309/396 (78%), Gaps = 14/396 (3%)
Query: 125 MANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLG 184
M ER NLM+M KLSIK L++SAL+LGR+LD+D+APLQQFFVVMEHCLKHGLK KK+F+G
Sbjct: 1 MMEERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKSFIG 60
Query: 185 QNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALI 244
QNKSF+GPLELVEKL PEA++I SV++LP LKT VGRGRAWL LALMQKKL++Y+K LI
Sbjct: 61 QNKSFFGPLELVEKLCPEASDIATSVRNLPELKTAVGRGRAWLYLALMQKKLADYLKVLI 120
Query: 245 NKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKD 304
+ K LLSEFYEP ALMMEEEG +I GLLVGLNV+DAN C+KGEDLDSQVGVIDFS+YLKD
Sbjct: 121 DNKHLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQVGVIDFSLYLKD 180
Query: 305 GNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANN 364
G + +IT +LDQKNYVEELNRHL+ TV +LQ K+D LEK+N+KL EEL+ A +
Sbjct: 181 VQDLDGGKEHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATD 240
Query: 365 RIITLQEEMERVKEESSYILESNRKG---PKQDRTAEGQALSEAR-----------KHLK 410
RI +LQEE ++++E++ I E + K KQD E + + R K LK
Sbjct: 241 RICSLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLK 300
Query: 411 EETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAF 470
EE ++RL++EKELE+QI M+ EME+AMK+LEKD EKQD LV+LRQQL++++A+ ++
Sbjct: 301 EEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFH 360
Query: 471 KLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQR 506
K Q+++ ++QK+E + E KTNQ+ +++KQ+E+R
Sbjct: 361 KAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEER 396
>gi|94721332 RUN and FYVE domain-containing 1 isoform b [Homo
sapiens]
Length = 600
Score = 465 bits (1196), Expect = e-131
Identities = 238/396 (60%), Positives = 309/396 (78%), Gaps = 14/396 (3%)
Query: 125 MANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLG 184
M ER NLM+M KLSIK L++SAL+LGR+LD+D+APLQQFFVVMEHCLKHGLK KK+F+G
Sbjct: 1 MMEERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKSFIG 60
Query: 185 QNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALI 244
QNKSF+GPLELVEKL PEA++I SV++LP LKT VGRGRAWL LALMQKKL++Y+K LI
Sbjct: 61 QNKSFFGPLELVEKLCPEASDIATSVRNLPELKTAVGRGRAWLYLALMQKKLADYLKVLI 120
Query: 245 NKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKD 304
+ K LLSEFYEP ALMMEEEG +I GLLVGLNV+DAN C+KGEDLDSQVGVIDFS+YLKD
Sbjct: 121 DNKHLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQVGVIDFSLYLKD 180
Query: 305 GNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANN 364
G + +IT +LDQKNYVEELNRHL+ TV +LQ K+D LEK+N+KL EEL+ A +
Sbjct: 181 VQDLDGGKEHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATD 240
Query: 365 RIITLQEEMERVKEESSYILESNRKG---PKQDRTAEGQALSEAR-----------KHLK 410
RI +LQEE ++++E++ I E + K KQD E + + R K LK
Sbjct: 241 RICSLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLK 300
Query: 411 EETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAF 470
EE ++RL++EKELE+QI M+ EME+AMK+LEKD EKQD LV+LRQQL++++A+ ++
Sbjct: 301 EEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFH 360
Query: 471 KLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQR 506
K Q+++ ++QK+E + E KTNQ+ +++KQ+E+R
Sbjct: 361 KAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEER 396
>gi|109240552 RUN and FYVE domain-containing 2 isoform b [Homo
sapiens]
Length = 403
Score = 419 bits (1077), Expect = e-117
Identities = 228/394 (57%), Positives = 282/394 (71%), Gaps = 48/394 (12%)
Query: 126 ANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQ 185
A ER NL+NMAKLSIKGLIESAL+ GRTLDSDY PLQQFFVVMEHCLKHGLK +K+FL
Sbjct: 8 AVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKVRKSFLSY 67
Query: 186 NKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALIN 245
NK+ WGPLELVEKL PEA EI ASV+DLPGL
Sbjct: 68 NKTIWGPLELVEKLYPEAEEIGASVRDLPGL----------------------------- 98
Query: 246 KKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDG 305
+EFYE +ALMMEEEGA+I GLLVGLNVIDAN C+KGEDLDSQVGVIDFSMYLK+
Sbjct: 99 -----NEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQVGVIDFSMYLKNE 153
Query: 306 NSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNR 365
E + QI AILDQKNYVEELNR LN+TV++L ++VD+LEKSNTKL EELA+A N
Sbjct: 154 EDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNN 213
Query: 366 IITLQEEMERVKEESSYIL--------------ESNRKGPKQDRTAEGQALSEARKHLKE 411
II LQEE +++ E+ IL E+ + K R + +EAR+ L++
Sbjct: 214 IIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRD 273
Query: 412 ETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFK 471
E+QLR DVE EL +Q+SM+ E+ELAMK+LEKD+ EKQD L+ LRQQL++++A+ E+ K
Sbjct: 274 ESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQK 333
Query: 472 LQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQ 505
LQ S+ G+K+K+E+ +RLEEKTN++ A ++QLEQ
Sbjct: 334 LQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQ 367
>gi|197304746 RUN domain containing 3B isoform c [Homo sapiens]
Length = 407
Score = 125 bits (314), Expect = 9e-29
Identities = 106/378 (28%), Positives = 175/378 (46%), Gaps = 46/378 (12%)
Query: 110 GGGSSGSGKHHPNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVME 169
GGG G K A ER NL+ + + S+K LI+ + T+D F ++E
Sbjct: 14 GGGGGGGKKSLSARNAAVERRNLITVCRFSVKTLIDRSCF--ETIDDSSPEFNNFAAILE 71
Query: 170 HCLKHGLKAKKTFLGQN--KSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWL 227
L H LK + T+ G +SFW + + + V + S++++ + + +GRAW+
Sbjct: 72 QILSHRLKGQVTWFGYESPRSFWDYIRVACRKVSQ--NCICSIENMENVSSSRAKGRAWI 129
Query: 228 RLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGE 287
R+ALM+K LSEY+ + + FYE A+++ EE ++AG+L+GLN ID +FC+KGE
Sbjct: 130 RVALMEKHLSEYISTALRDFKTTRRFYEDGAIVLGEEANMLAGMLLGLNAIDFSFCLKGE 189
Query: 288 DLD-SQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVD 346
LD S VID++ YLK SS D EEL T+ + ++
Sbjct: 190 GLDGSFPAVIDYTPYLKYIQSSDSISSD------------EEELR-----TLGSSGSESS 232
Query: 347 ALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEAR 406
E + N+ ++++ + E+ Y+ E R ++++ +E + ++
Sbjct: 233 TPENVGPPFLMDENSWFNKCKRVKQKYQLTLEQKGYLEELLRL--RENQLSESVSQNKIL 290
Query: 407 KHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKH 466
E++ L +EKE LE + E QD L S Q LD L A
Sbjct: 291 LQRIEDSDLAHKLEKE----------------QLEYIIVELQDQLKSY-QSLDQLSA--- 330
Query: 467 ELAFKLQSSDLGVKQKSE 484
E++ S D G Q+ +
Sbjct: 331 EVSLSQTSLDPGQSQEGD 348
>gi|197304744 RUN domain containing 3B isoform b [Homo sapiens]
Length = 456
Score = 123 bits (309), Expect = 3e-28
Identities = 73/208 (35%), Positives = 113/208 (54%), Gaps = 7/208 (3%)
Query: 110 GGGSSGSGKHHPNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVME 169
GGG G K A ER NL+ + + S+K LI+ + T+D F ++E
Sbjct: 14 GGGGGGGKKSLSARNAAVERRNLITVCRFSVKTLIDRSCF--ETIDDSSPEFNNFAAILE 71
Query: 170 HCLKHGLKAKKTFLGQN--KSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWL 227
L H LK + T+ G +SFW + + + V + S++++ + + +GRAW+
Sbjct: 72 QILSHRLKGQVTWFGYESPRSFWDYIRVACRKVSQ--NCICSIENMENVSSSRAKGRAWI 129
Query: 228 RLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGE 287
R+ALM+K LSEY+ + + FYE A+++ EE ++AG+L+GLN ID +FC+KGE
Sbjct: 130 RVALMEKHLSEYISTALRDFKTTRRFYEDGAIVLGEEANMLAGMLLGLNAIDFSFCLKGE 189
Query: 288 DLD-SQVGVIDFSMYLKDGNSSKGTEGD 314
LD S VID++ YLK SS D
Sbjct: 190 GLDGSFPAVIDYTPYLKYIQSSDSISSD 217
>gi|221307580 RUN domain containing 3A isoform 3 [Homo sapiens]
Length = 400
Score = 113 bits (283), Expect = 4e-25
Identities = 83/307 (27%), Positives = 139/307 (45%), Gaps = 57/307 (18%)
Query: 116 SGKHHPNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHG 175
S K + +A ER NL+ + + S+K L+E +D F ++E L H
Sbjct: 15 SSKKASSRNVAVERKNLITVCRFSVKTLLEKYT--AEPIDDSSEEFVNFAAILEQILSHR 72
Query: 176 LKAKKTFLGQN--KSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQ 233
K ++ + + FW + L VP +S++++ + T +GRAW+R+ALM+
Sbjct: 73 FKGPVSWFSSDGQRGFWDYIRLACSKVPN--NCVSSIENMENISTARAKGRAWIRVALME 130
Query: 234 KKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQV 293
K++SEY+ + FY+ A+M+ +E I+ G+L+GL+ ID +FC+KGE LD +
Sbjct: 131 KRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGEVLDGKT 190
Query: 294 G-VIDFSMYLK--------------------------------------DGNSSKGTEGD 314
VID++ YLK D SK + +
Sbjct: 191 PVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKME 250
Query: 315 GQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNR--------I 366
+ + QK Y+EEL R + + +L+A+ L+ EE A N R I
Sbjct: 251 QKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQ----LEEAAAQNQREKRELEGVI 306
Query: 367 ITLQEEM 373
+ LQE++
Sbjct: 307 LELQEQL 313
>gi|19923090 RUN domain containing 3B isoform a [Homo sapiens]
Length = 473
Score = 112 bits (281), Expect = 6e-25
Identities = 73/225 (32%), Positives = 113/225 (50%), Gaps = 24/225 (10%)
Query: 110 GGGSSGSGKHHPNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVME 169
GGG G K A ER NL+ + + S+K LI+ + T+D F ++E
Sbjct: 14 GGGGGGGKKSLSARNAAVERRNLITVCRFSVKTLIDRSCF--ETIDDSSPEFNNFAAILE 71
Query: 170 HCLKHGLK-----------------AKKTFLGQN--KSFWGPLELVEKLVPEAAEITASV 210
L H LK + T+ G +SFW + + + V + S+
Sbjct: 72 QILSHRLKEISQSCRWLAHLQIPLQGQVTWFGYESPRSFWDYIRVACRKVSQ--NCICSI 129
Query: 211 KDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAG 270
+++ + + +GRAW+R+ALM+K LSEY+ + + FYE A+++ EE ++AG
Sbjct: 130 ENMENVSSSRAKGRAWIRVALMEKHLSEYISTALRDFKTTRRFYEDGAIVLGEEANMLAG 189
Query: 271 LLVGLNVIDANFCMKGEDLD-SQVGVIDFSMYLKDGNSSKGTEGD 314
+L+GLN ID +FC+KGE LD S VID++ YLK SS D
Sbjct: 190 MLLGLNAIDFSFCLKGEGLDGSFPAVIDYTPYLKYIQSSDSISSD 234
>gi|221307578 RUN domain containing 3A isoform 1 [Homo sapiens]
Length = 446
Score = 108 bits (271), Expect = 9e-24
Identities = 86/313 (27%), Positives = 140/313 (44%), Gaps = 64/313 (20%)
Query: 116 SGKHHPNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHG 175
S K + +A ER NL+ + + S+K L+E +D F ++E L H
Sbjct: 15 SSKKASSRNVAVERKNLITVCRFSVKTLLEKYT--AEPIDDSSEEFVNFAAILEQILSHR 72
Query: 176 LKAKK--------TFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWL 227
KA + GQ + FW + L VP +S++++ + T +GRAW+
Sbjct: 73 FKACAPAGPVSWFSSDGQ-RGFWDYIRLACSKVPN--NCVSSIENMENISTARAKGRAWI 129
Query: 228 RLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGE 287
R+ALM+K++SEY+ + FY+ A+M+ +E I+ G+L+GL+ ID +FC+KGE
Sbjct: 130 RVALMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGE 189
Query: 288 DLDSQVG-VIDFSMYLK--------------------------------------DGNSS 308
LD + VID++ YLK D S
Sbjct: 190 VLDGKTPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYS 249
Query: 309 KGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNR--- 365
K + + + + QK Y+EEL R + + +L+A+ L+ EE A N R
Sbjct: 250 KWHKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQ----LEEAAAQNQREKR 305
Query: 366 -----IITLQEEM 373
I+ LQE++
Sbjct: 306 ELEGVILELQEQL 318
>gi|5730015 RUN domain containing 3A isoform 2 [Homo sapiens]
Length = 405
Score = 108 bits (271), Expect = 9e-24
Identities = 86/313 (27%), Positives = 140/313 (44%), Gaps = 64/313 (20%)
Query: 116 SGKHHPNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHG 175
S K + +A ER NL+ + + S+K L+E +D F ++E L H
Sbjct: 15 SSKKASSRNVAVERKNLITVCRFSVKTLLEKYT--AEPIDDSSEEFVNFAAILEQILSHR 72
Query: 176 LKAKK--------TFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWL 227
KA + GQ + FW + L VP +S++++ + T +GRAW+
Sbjct: 73 FKACAPAGPVSWFSSDGQ-RGFWDYIRLACSKVPN--NCVSSIENMENISTARAKGRAWI 129
Query: 228 RLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGE 287
R+ALM+K++SEY+ + FY+ A+M+ +E I+ G+L+GL+ ID +FC+KGE
Sbjct: 130 RVALMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGE 189
Query: 288 DLDSQVG-VIDFSMYLK--------------------------------------DGNSS 308
LD + VID++ YLK D S
Sbjct: 190 VLDGKTPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYS 249
Query: 309 KGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNR--- 365
K + + + + QK Y+EEL R + + +L+A+ L+ EE A N R
Sbjct: 250 KWHKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQ----LEEAAAQNQREKR 305
Query: 366 -----IITLQEEM 373
I+ LQE++
Sbjct: 306 ELEGVILELQEQL 318
>gi|157738667 FYVE and coiled-coil domain containing 1 [Homo
sapiens]
Length = 1478
Score = 70.1 bits (170), Expect = 5e-12
Identities = 78/336 (23%), Positives = 155/336 (46%), Gaps = 18/336 (5%)
Query: 151 GRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEITASV 210
G + D L +F +E+ L+ K K T LG K +W V A + V
Sbjct: 32 GEPITDDSTSLHKFSYKLEYLLQFDQKEKATLLGNKKDYWDYFCACLAKVKGANDGIRFV 91
Query: 211 KDLPGLKTPVGRGRAWLRLALMQKKLSEYM-KALINKKELLSEFYEPNALMMEEEGAIIA 269
K + L+T +G+GRA++R +L+ ++L++ + + +N K +Y + + + + I
Sbjct: 92 KSISELRTSLGKGRAFIRYSLVHQRLADTLQQCFMNTKVTSDWYYARSPFLQPKLSSDIV 151
Query: 270 GLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSS---KGTEGDGQITAILDQKNY 326
G L L + + +G DLD+ L G+S+ K +++++
Sbjct: 152 GQLYELTEVQFDLASRGFDLDAAWPTF-ARRTLTTGSSAYLWKPPSRSSSMSSLVSSYLQ 210
Query: 327 VEEL--NRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYIL 384
+E+ N LN+ +NN +ALE + ++ EL R L+E M+++ E+ +
Sbjct: 211 TQEMVSNFDLNSPLNN-----EALEGFD-EMRLELDQLEVREKQLRERMQQLDRENQELR 264
Query: 385 ESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMR---QEMELAMKMLE 441
+ + +Q +T + + A +++ T L +++K+ E+ + + +E++ ++ LE
Sbjct: 265 AAVSQQGEQLQTERERGRTAAEDNVR-LTCLVAELQKQWEVTQATQNTVKELQTCLQGLE 323
Query: 442 KDVCEK-QDALVSLRQQLDDLRALKHELAFKLQSSD 476
EK +D +LR+ L+ L EL S D
Sbjct: 324 LGAAEKEEDYHTALRRLESMLQPLAQELEATRDSLD 359
Score = 37.0 bits (84), Expect = 0.042
Identities = 46/190 (24%), Positives = 79/190 (41%), Gaps = 28/190 (14%)
Query: 322 DQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEE---LAVANNRIITLQEEMERVKE 378
D + L L L+A D+L+K N L LA+A + T + R +
Sbjct: 332 DYHTALRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEP 391
Query: 379 ESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMK 438
S D E Q L E + L+ E R VE+ + ++ ++
Sbjct: 392 IPS------------DAAQEMQELGEKLQALERE---RTKVEE-------VNRQQSAQLE 429
Query: 439 MLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSEL---NSRLEEKTNQ 495
L K++ K+DA SL + + ++ L+ EL+ K Q +D ++ EL S EE+ +
Sbjct: 430 QLVKELQLKEDARASLERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAE 489
Query: 496 MAATIKQLEQ 505
+ KQ ++
Sbjct: 490 LRREKKQQQE 499
Score = 36.6 bits (83), Expect = 0.055
Identities = 43/185 (23%), Positives = 84/185 (45%), Gaps = 15/185 (8%)
Query: 316 QITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVA---NNRII----T 368
Q+ + + +EE + L ++L +V LE+ EL VA N ++ +
Sbjct: 521 QLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSS 580
Query: 369 LQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQIS 428
LQE + +EE + E+ K ++ + L +A + L++E Q + + LE ++
Sbjct: 581 LQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELEKELQNVVGRNQLLEGKLQ 640
Query: 429 MRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGV-KQKSELNS 487
Q A++ E + Q +L SL + +R L ++++S L V K K + +
Sbjct: 641 ALQADYQALQQRESAI---QGSLASLEAEQASIR----HLGDQMEASLLAVRKAKEAMKA 693
Query: 488 RLEEK 492
++ EK
Sbjct: 694 QMAEK 698
Score = 34.3 bits (77), Expect = 0.27
Identities = 36/150 (24%), Positives = 69/150 (46%), Gaps = 13/150 (8%)
Query: 316 QITAILDQKNYVEELNR----HLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQE 371
++ A+ ++ VEE+NR L V LQ K DA S +L +E+A LQE
Sbjct: 406 KLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDA-RASLERLVKEMA-------PLQE 457
Query: 372 EMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQ 431
E+ +E+ + ++ + E + L+E R+ K++ + + +E+E+ Q
Sbjct: 458 ELSGKGQEADQLWRRLQELLAHTSSWE-EELAELRREKKQQQEEKELLEQEVRSLTRQLQ 516
Query: 432 EMELAMKMLEKDVCEKQDALVSLRQQLDDL 461
+E + + + V + ++ L Q D L
Sbjct: 517 FLETQLAQVSQHVSDLEEQKKQLIQDKDHL 546
Score = 34.3 bits (77), Expect = 0.27
Identities = 43/193 (22%), Positives = 80/193 (41%), Gaps = 24/193 (12%)
Query: 332 RHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYI-------- 383
+ L A V +LQAK+ A K+ +L++A + + ++++KE++ +
Sbjct: 786 QRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQEL 845
Query: 384 ---------LESNRKGPKQDRTAEGQALSEARKHLK---EETQL-RLDVEKELEMQISMR 430
L+ R Q R E +AL E K EE QL +++++L +
Sbjct: 846 LQCSEREGALQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDT 905
Query: 431 QEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLE 490
E+ + + L + ++AL Q+L D + L+ G++Q+ E L+
Sbjct: 906 AELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKE---SLQ 962
Query: 491 EKTNQMAATIKQL 503
EK A L
Sbjct: 963 EKLKAAKAAAGSL 975
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 61.2 bits (147), Expect = 2e-09
Identities = 50/195 (25%), Positives = 98/195 (50%), Gaps = 21/195 (10%)
Query: 328 EELNRHLNATVNNLQAK-------VDALEKSNTKLTEELAVANNRIITLQEEMERVKE-- 378
EE+N L A L+ + +D LE + K+ +E N++ L EEM + E
Sbjct: 930 EEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEII 989
Query: 379 -----ESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEM 433
E + E++++ + E + + + +K E Q+ D+E LE + +R ++
Sbjct: 990 AKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVD-DLEGSLEQEKKVRMDL 1048
Query: 434 ELAMKMLEKDVCEKQDALVSL---RQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLE 490
E A + LE D+ Q++++ L +QQLD+ K F+L + + ++ + L S+L+
Sbjct: 1049 ERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKD---FELNALNARIEDEQALGSQLQ 1105
Query: 491 EKTNQMAATIKQLEQ 505
+K ++ A I++LE+
Sbjct: 1106 KKLKELQARIEELEE 1120
Score = 53.5 bits (127), Expect = 4e-07
Identities = 48/200 (24%), Positives = 99/200 (49%), Gaps = 25/200 (12%)
Query: 312 EGDGQIT--AILDQKNYVEELNRHLNAT---VNNLQAKVDALEKSNTKLTEELAVANNRI 366
EGD ++T +I+D +N ++L+ L +N L A+++ + ++L ++L RI
Sbjct: 1056 EGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARI 1115
Query: 367 ITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQ 426
L+EE+E + + + + + D + E + +SE + T +++++ K+ E +
Sbjct: 1116 EELEEELEAERTARAKV-----EKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAE 1170
Query: 427 I-SMRQEMELAMKMLEKDVC----EKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQ 481
MR+++E A E + D++ L +Q+D+L+ +K +L K+
Sbjct: 1171 FQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLE----------KE 1220
Query: 482 KSELNSRLEEKTNQMAATIK 501
KSE L++ T+ M IK
Sbjct: 1221 KSEFKLELDDVTSNMEQIIK 1240
Score = 41.6 bits (96), Expect = 0.002
Identities = 40/206 (19%), Positives = 90/206 (43%), Gaps = 14/206 (6%)
Query: 308 SKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRII 367
SK E + + Q+ ++ N L+ ++ +A + L + T++L ++
Sbjct: 1261 SKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQL- 1319
Query: 368 TLQEEMERVKEESSYILESNRKGP---KQDRTAEGQALSEARKHLK----EETQLRLDVE 420
EE + K ++ L+S R ++ E +A +E ++ L E Q R E
Sbjct: 1320 ---EEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYE 1376
Query: 421 KELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVK 480
+ I +E+E A K L + + E ++A+ ++ + L KH L +++ + V+
Sbjct: 1377 TDA---IQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVE 1433
Query: 481 QKSELNSRLEEKTNQMAATIKQLEQR 506
+ + + L++K + + +Q+
Sbjct: 1434 RSNAAAAALDKKQRNFDKILAEWKQK 1459
Score = 41.2 bits (95), Expect = 0.002
Identities = 46/192 (23%), Positives = 88/192 (45%), Gaps = 19/192 (9%)
Query: 327 VEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRI-------ITLQEEMERVKEE 379
VE N L A + L+A V+ E+S +EL + R+ +L + +++ +
Sbjct: 1674 VERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDAD 1733
Query: 380 SSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQI---SMRQEMELA 436
S + + ++ R AE +A+K + + + +++KE + M++ ME
Sbjct: 1734 LSQLQTEVEEAVQECRNAE----EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQT 1789
Query: 437 MKMLEKDVCE-KQDALVSLRQQLDDL----RALKHELAFKLQSSDLGVKQKSELNSRLEE 491
+K L+ + E +Q AL ++QL L R L++EL + + + VK + R++E
Sbjct: 1790 IKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKE 1849
Query: 492 KTNQMAATIKQL 503
T Q K L
Sbjct: 1850 LTYQTEEDRKNL 1861
Score = 37.4 bits (85), Expect = 0.032
Identities = 39/182 (21%), Positives = 78/182 (42%), Gaps = 13/182 (7%)
Query: 327 VEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILES 386
+E++ + L A LQ+ ALE++ L E +I+ Q E ++K E L
Sbjct: 1526 LEKVRKQLEAEKMELQS---ALEEAEASLEHE----EGKILRAQLEFNQIKAEIERKLAE 1578
Query: 387 NRKGPKQDRTAEGQALSEARKHLKEETQLR---LDVEKELEMQISMRQEMELAMKMLEKD 443
+ +Q + + + + L ET+ R L V+K++E ++ EME+ + +
Sbjct: 1579 KDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLN---EMEIQLSHANRM 1635
Query: 444 VCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQL 503
E Q + SL+ L D + + + N+ L+ + ++ A ++Q
Sbjct: 1636 AAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQT 1695
Query: 504 EQ 505
E+
Sbjct: 1696 ER 1697
Score = 33.1 bits (74), Expect = 0.61
Identities = 28/113 (24%), Positives = 53/113 (46%), Gaps = 5/113 (4%)
Query: 394 DRTAEGQALSEARKHLKEETQLRLDVEKELEMQ-ISMRQEMELAMKMLEKDVCEKQDALV 452
+R E ++ E LKE + KELE + +S+ QE L+ V +QD L
Sbjct: 844 EREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKN----DLQLQVQAEQDNLA 899
Query: 453 SLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQ 505
++ D L K +L K++ + ++ + E+N+ L K ++ +L++
Sbjct: 900 DAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKR 952
Score = 32.0 bits (71), Expect = 1.4
Identities = 32/164 (19%), Positives = 80/164 (48%), Gaps = 8/164 (4%)
Query: 342 QAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQA 401
+ ++ ++++ T+L E L + R L+E+M + +E + + + +QD A+ +
Sbjct: 846 EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDL--QLQVQAEQDNLADAEE 903
Query: 402 LSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDL 461
+ + +K + QL V KE+ ++ +EM + ++ + +D L++ +DDL
Sbjct: 904 RCD--QLIKNKIQLEAKV-KEMNERLEDEEEMNAELTAKKRKL---EDECSELKRDIDDL 957
Query: 462 RALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQ 505
++ + +++ VK +E + L+E ++ K L++
Sbjct: 958 ELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQE 1001
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 58.5 bits (140), Expect = 1e-08
Identities = 66/282 (23%), Positives = 122/282 (43%), Gaps = 27/282 (9%)
Query: 233 QKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQ 292
QK E K+ +KEL + L+ E+ + N++DA E+ Q
Sbjct: 858 QKTKDELAKSEAKRKELEEKLV---TLVQEKNDLQLQVQAESENLLDA------EERCDQ 908
Query: 293 VGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSN 352
+ F + K ++ E + +I A L K R L + L+ +D LE +
Sbjct: 909 LIKAKFQLEAKIKEVTERAEDEEEINAELTAKK------RKLEDECSELKKDIDDLELTL 962
Query: 353 TKLTEELAVANNRIITLQEEMERVKEESSYI------LESNRKGPKQDRTAEGQALSEAR 406
K+ +E N++ L EE+ + E + + L+ + D AE ++
Sbjct: 963 AKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLN 1022
Query: 407 KHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSL---RQQLDDLRA 463
K + Q D+E LE + +R ++E + LE D+ Q++++ L +QQLD+
Sbjct: 1023 KTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLK 1082
Query: 464 LKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQ 505
K +LQS V+ + L + ++K ++ A I++LE+
Sbjct: 1083 KKDFEYCQLQSK---VEDEQTLGLQFQKKIKELQARIEELEE 1121
Score = 38.1 bits (87), Expect = 0.019
Identities = 44/195 (22%), Positives = 85/195 (43%), Gaps = 32/195 (16%)
Query: 320 ILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEME-RVKE 378
I ++ +E+L R+ TV +Q+ +DA +S N I L+++ME + E
Sbjct: 1577 IAEKDEEIEQLKRNYQRTVETMQSALDAEVRS-----------RNEAIRLKKKMEGDLNE 1625
Query: 379 ESSYILESNRKGP---KQDRTAEGQALSEARKHLKEETQLRLDVEKEL------------ 423
+ +NR+ K R+ +GQ L + + HL + + + D++++L
Sbjct: 1626 IEIQLSHANRQAAETLKHLRSVQGQ-LKDTQLHLDDALRGQEDLKEQLAIVERRANLLQA 1684
Query: 424 ---EMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVK 480
E++ ++ Q E A K+ E+++ + + + L Q L K +L L V+
Sbjct: 1685 EVEELRATLEQ-TERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVE 1743
Query: 481 QKSELNSRLEEKTNQ 495
S EEK +
Sbjct: 1744 DASRDARNAEEKAKK 1758
Score = 37.7 bits (86), Expect = 0.025
Identities = 46/190 (24%), Positives = 79/190 (41%), Gaps = 12/190 (6%)
Query: 319 AILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKE 378
A L + V L + +V L ++D L++ KL +E + I L ME V +
Sbjct: 1182 ATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSK 1241
Query: 379 ESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMK 438
+ + + R Q A G+ E ++ L E T + ++ E +E E +
Sbjct: 1242 SKANLEKICRTLEDQLSEARGKN-EEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVS 1300
Query: 439 MLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSS----DLGVKQ-------KSELNS 487
L + L++QL++ K+ LA LQSS DL +Q K+EL
Sbjct: 1301 QLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQR 1360
Query: 488 RLEEKTNQMA 497
L + +++A
Sbjct: 1361 ALSKANSEVA 1370
Score = 34.3 bits (77), Expect = 0.27
Identities = 30/160 (18%), Positives = 73/160 (45%), Gaps = 15/160 (9%)
Query: 360 AVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDV 419
A + T++EE ++ K+E + E+ RK ++ Q ++ + ++ E++ LD
Sbjct: 844 AETEKEMATMKEEFQKTKDELAKS-EAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDA 902
Query: 420 EKELEMQISMRQEMELAMKMLEKDVCEKQ--------------DALVSLRQQLDDLRALK 465
E+ + I + ++E +K + + +++ D L++ +DDL
Sbjct: 903 EERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 962
Query: 466 HELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQ 505
++ + +++ VK +E S L+E ++ K L++
Sbjct: 963 AKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQE 1002
Score = 34.3 bits (77), Expect = 0.27
Identities = 53/228 (23%), Positives = 97/228 (42%), Gaps = 32/228 (14%)
Query: 289 LDSQVGVIDFSMYLKDGNSSKGTEGD-GQITAILDQKN-YVEELNRHLNATVNNL---QA 343
LD++V + ++ LK K EGD +I L N E +HL + L Q
Sbjct: 1602 LDAEVRSRNEAIRLK-----KKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQL 1656
Query: 344 KVDALEKSNTKLTEELAVANNRIITLQEEMERV-----------KEESSYILESNRKGPK 392
+D + L E+LA+ R LQ E+E + K +L+SN +
Sbjct: 1657 HLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNER--V 1714
Query: 393 QDRTAEGQALSEARKHLKEE-TQLRLDVEKELEMQISMRQEMELAM---KMLEKDVCEKQ 448
Q + +L +K L+ + QL+ +VE + ++ + A+ M+ +++ ++Q
Sbjct: 1715 QLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQ 1774
Query: 449 DALVSLRQQLDDLRALKHELAFKLQSSDL-----GVKQKSELNSRLEE 491
D L + +L +L +L ++ G KQ +L +R+ E
Sbjct: 1775 DTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRE 1822
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 58.5 bits (140), Expect = 1e-08
Identities = 43/206 (20%), Positives = 99/206 (48%), Gaps = 15/206 (7%)
Query: 314 DGQITAILDQKNYVEELNRHLNATVNNLQAK-------VDALEKSNTKLTEELAVANNRI 366
+ +I + ++ EE+N L A L+ + +D LE + K+ +E N++
Sbjct: 922 EAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV 981
Query: 367 ITLQEEM-------ERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDV 419
L EEM ++ +E + E++++ + E + + + +K E Q+ D+
Sbjct: 982 KNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVD-DL 1040
Query: 420 EKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGV 479
E LE + +R ++E A + LE D+ Q++++ + + L + F++ + +
Sbjct: 1041 EGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKI 1100
Query: 480 KQKSELNSRLEEKTNQMAATIKQLEQ 505
+ + L +L++K ++ A I++LE+
Sbjct: 1101 EDEQALGIQLQKKIKELQARIEELEE 1126
Score = 49.7 bits (117), Expect = 6e-06
Identities = 49/216 (22%), Positives = 105/216 (48%), Gaps = 30/216 (13%)
Query: 312 EGDGQIT--AILDQKNYVEELNRHLNAT---VNNLQAKVDALEKSNTKLTEELAVANNRI 366
EGD ++ +I+D +N ++L+ L ++NLQ+K++ + +L +++ RI
Sbjct: 1062 EGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARI 1121
Query: 367 ITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKE-----ETQLRLDVEK 421
L+EE+E + ++R ++ R+ + L E + L+E Q+ ++ ++
Sbjct: 1122 EELEEEIEAER--------ASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKR 1173
Query: 422 ELEMQISMRQEMELAMKMLEKDVC----EKQDALVSLRQQLDDLRALKHEL-----AFKL 472
E E Q MR+++E A E + D++ L +Q+D+L+ +K +L K+
Sbjct: 1174 EAEFQ-KMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKM 1232
Query: 473 QSSDL--GVKQKSELNSRLEEKTNQMAATIKQLEQR 506
+ DL V+ S+ LE+ + + +L+ +
Sbjct: 1233 EIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSK 1268
Score = 42.4 bits (98), Expect = 0.001
Identities = 64/286 (22%), Positives = 116/286 (40%), Gaps = 51/286 (17%)
Query: 246 KKELLSEFYEPNALMMEEEGAIIAGLLVGLNVI----DANFCMKGEDLD----------- 290
K EL + E A + EEG I+ + + LN + D K E++D
Sbjct: 1543 KCELQAALEEAEASLEHEEGKILR-IQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVE 1601
Query: 291 SQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELN-------RHLNATVNNLQA 343
S +D + ++ + +G + + Q N+ + R+ + + Q
Sbjct: 1602 SMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQI 1661
Query: 344 KVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQAL- 402
+D +S L E+LA+ R LQ E+E ++ LE + K AE + L
Sbjct: 1662 HLDDALRSQEDLKEQLAMVERRANLLQAEIEELRA----TLEQTERSRK---IAEQELLD 1714
Query: 403 -SEARKHLKEETQLRLDVEKELEMQIS-MRQEMELAMKMLEKDVCEKQDALVSLRQQLDD 460
SE + L + ++ +K+LE IS M+ EME ++ E ++A ++ + D
Sbjct: 1715 ASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQ-------EARNAEEKAKKAITD 1767
Query: 461 LRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQR 506
+ EL K++ + ++ LE M T+K L+ R
Sbjct: 1768 AAMMAEEL-----------KKEQDTSAHLERMKKNMEQTVKDLQLR 1802
Score = 37.7 bits (86), Expect = 0.025
Identities = 43/192 (22%), Positives = 84/192 (43%), Gaps = 34/192 (17%)
Query: 344 KVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKG------------P 391
+V L NT L I +Q EME + +E+ E +K
Sbjct: 1718 RVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKK 1777
Query: 392 KQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMR--QEMELAMKMLEKDVCEKQ- 448
+QD +A + + + + ++ QLRLD ++L ++ + Q++E ++ LE +V +Q
Sbjct: 1778 EQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQK 1837
Query: 449 ---DALVSLRQQLDDLRALKH-------------ELAFKLQSSDLGVKQKSELNSRLEEK 492
+A+ LR+ ++ L + +L KLQ+ K+++E EE+
Sbjct: 1838 RNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAE---EAEEQ 1894
Query: 493 TNQMAATIKQLE 504
+N A ++L+
Sbjct: 1895 SNTNLAKFRKLQ 1906
Score = 33.1 bits (74), Expect = 0.61
Identities = 39/148 (26%), Positives = 63/148 (42%), Gaps = 19/148 (12%)
Query: 337 TVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRT 396
+V L ++D L++ KL +E + I L +E V + + K RT
Sbjct: 1205 SVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNL-------EKMCRT 1257
Query: 397 AEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQ-------- 448
E Q LSE + KEE Q RL + + + E + ++ EK+ Q
Sbjct: 1258 LEDQ-LSELKS--KEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAF 1314
Query: 449 -DALVSLRQQLDDLRALKHELAFKLQSS 475
+ L++QL++ K+ LA LQSS
Sbjct: 1315 TQQIEELKRQLEEEIKAKNALAHALQSS 1342
Score = 32.0 bits (71), Expect = 1.4
Identities = 38/170 (22%), Positives = 81/170 (47%), Gaps = 15/170 (8%)
Query: 347 ALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEAR 406
AL K+NT++ + I EE+E K++ + L++ + + A+ +L + +
Sbjct: 1366 ALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEE-HVEAVNAKCASLEKTK 1424
Query: 407 KHLKEETQ-LRLDVEKELEMQISMRQEMELAMKMLE--KDVCEKQDALVSLRQQLDDLRA 463
+ L+ E + L LDVE+ ++ ++ K+L K CE+ A + Q+ + R+
Sbjct: 1425 QRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQK--EARS 1482
Query: 464 LKHELAFKLQSS--------DLGVKQKSELNSRLEEKTNQMAATIKQLEQ 505
L EL FK++++ + ++ L + + T Q+A K++ +
Sbjct: 1483 LGTEL-FKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHE 1531
Score = 31.6 bits (70), Expect = 1.8
Identities = 28/160 (17%), Positives = 71/160 (44%), Gaps = 15/160 (9%)
Query: 360 AVANNRIITLQEEMERVKEESSYILESNRKGPKQDRT--------------AEGQALSEA 405
A + T++EE +++K+E + E+ RK ++ AE + L++A
Sbjct: 849 AETEKEMATMKEEFQKIKDELAKS-EAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADA 907
Query: 406 RKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALK 465
+ + + ++ +E +++ ++ E L + +D L++ +DDL
Sbjct: 908 EERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 967
Query: 466 HELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQ 505
++ + +++ VK +E + L+E ++ K L++
Sbjct: 968 AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQE 1007
Score = 31.2 bits (69), Expect = 2.3
Identities = 40/176 (22%), Positives = 76/176 (43%), Gaps = 17/176 (9%)
Query: 324 KNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYI 383
+N VE+L + T A AL+K + LA + E+E ++E+ +
Sbjct: 1428 QNEVEDLMLDVERT----NAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSL 1483
Query: 384 LES--NRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLE 441
K ++ + + L K+L++E D+ +++ E+E K +E
Sbjct: 1484 GTELFKIKNAYEESLDQLETLKRENKNLQQEIS---DLTEQIAEGGKRIHELEKIKKQVE 1540
Query: 442 KDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQ-KSELNSRLEEKTNQM 496
++ CE Q AL +L+HE K+ L + Q KSE++ ++ EK ++
Sbjct: 1541 QEKCELQAALEEAE------ASLEHEEG-KILRIQLELNQVKSEVDRKIAEKDEEI 1589
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 58.5 bits (140), Expect = 1e-08
Identities = 43/206 (20%), Positives = 99/206 (48%), Gaps = 15/206 (7%)
Query: 314 DGQITAILDQKNYVEELNRHLNATVNNLQAK-------VDALEKSNTKLTEELAVANNRI 366
+ +I + ++ EE+N L A L+ + +D LE + K+ +E N++
Sbjct: 922 EAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV 981
Query: 367 ITLQEEM-------ERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDV 419
L EEM ++ +E + E++++ + E + + + +K E Q+ D+
Sbjct: 982 KNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVD-DL 1040
Query: 420 EKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGV 479
E LE + +R ++E A + LE D+ Q++++ + + L + F++ + +
Sbjct: 1041 EGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKI 1100
Query: 480 KQKSELNSRLEEKTNQMAATIKQLEQ 505
+ + L +L++K ++ A I++LE+
Sbjct: 1101 EDEQALGIQLQKKIKELQARIEELEE 1126
Score = 49.7 bits (117), Expect = 6e-06
Identities = 49/216 (22%), Positives = 105/216 (48%), Gaps = 30/216 (13%)
Query: 312 EGDGQIT--AILDQKNYVEELNRHLNAT---VNNLQAKVDALEKSNTKLTEELAVANNRI 366
EGD ++ +I+D +N ++L+ L ++NLQ+K++ + +L +++ RI
Sbjct: 1062 EGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARI 1121
Query: 367 ITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKE-----ETQLRLDVEK 421
L+EE+E + ++R ++ R+ + L E + L+E Q+ ++ ++
Sbjct: 1122 EELEEEIEAER--------ASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKR 1173
Query: 422 ELEMQISMRQEMELAMKMLEKDVC----EKQDALVSLRQQLDDLRALKHEL-----AFKL 472
E E Q MR+++E A E + D++ L +Q+D+L+ +K +L K+
Sbjct: 1174 EAEFQ-KMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKM 1232
Query: 473 QSSDL--GVKQKSELNSRLEEKTNQMAATIKQLEQR 506
+ DL V+ S+ LE+ + + +L+ +
Sbjct: 1233 EIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSK 1268
Score = 42.4 bits (98), Expect = 0.001
Identities = 64/286 (22%), Positives = 116/286 (40%), Gaps = 51/286 (17%)
Query: 246 KKELLSEFYEPNALMMEEEGAIIAGLLVGLNVI----DANFCMKGEDLD----------- 290
K EL + E A + EEG I+ + + LN + D K E++D
Sbjct: 1543 KCELQAALEEAEASLEHEEGKILR-IQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVE 1601
Query: 291 SQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELN-------RHLNATVNNLQA 343
S +D + ++ + +G + + Q N+ + R+ + + Q
Sbjct: 1602 SMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQI 1661
Query: 344 KVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQAL- 402
+D +S L E+LA+ R LQ E+E ++ LE + K AE + L
Sbjct: 1662 HLDDALRSQEDLKEQLAMVERRANLLQAEIEELRA----TLEQTERSRK---IAEQELLD 1714
Query: 403 -SEARKHLKEETQLRLDVEKELEMQIS-MRQEMELAMKMLEKDVCEKQDALVSLRQQLDD 460
SE + L + ++ +K+LE IS M+ EME ++ E ++A ++ + D
Sbjct: 1715 ASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQ-------EARNAEEKAKKAITD 1767
Query: 461 LRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQR 506
+ EL K++ + ++ LE M T+K L+ R
Sbjct: 1768 AAMMAEEL-----------KKEQDTSAHLERMKKNMEQTVKDLQLR 1802
Score = 37.7 bits (86), Expect = 0.025
Identities = 43/192 (22%), Positives = 84/192 (43%), Gaps = 34/192 (17%)
Query: 344 KVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKG------------P 391
+V L NT L I +Q EME + +E+ E +K
Sbjct: 1718 RVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKK 1777
Query: 392 KQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMR--QEMELAMKMLEKDVCEKQ- 448
+QD +A + + + + ++ QLRLD ++L ++ + Q++E ++ LE +V +Q
Sbjct: 1778 EQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQK 1837
Query: 449 ---DALVSLRQQLDDLRALKH-------------ELAFKLQSSDLGVKQKSELNSRLEEK 492
+A+ LR+ ++ L + +L KLQ+ K+++E EE+
Sbjct: 1838 RNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAE---EAEEQ 1894
Query: 493 TNQMAATIKQLE 504
+N A ++L+
Sbjct: 1895 SNTNLAKFRKLQ 1906
Score = 33.1 bits (74), Expect = 0.61
Identities = 39/148 (26%), Positives = 63/148 (42%), Gaps = 19/148 (12%)
Query: 337 TVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRT 396
+V L ++D L++ KL +E + I L +E V + + K RT
Sbjct: 1205 SVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNL-------EKMCRT 1257
Query: 397 AEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQ-------- 448
E Q LSE + KEE Q RL + + + E + ++ EK+ Q
Sbjct: 1258 LEDQ-LSELKS--KEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAF 1314
Query: 449 -DALVSLRQQLDDLRALKHELAFKLQSS 475
+ L++QL++ K+ LA LQSS
Sbjct: 1315 TQQIEELKRQLEEEIKAKNALAHALQSS 1342
Score = 32.0 bits (71), Expect = 1.4
Identities = 38/170 (22%), Positives = 81/170 (47%), Gaps = 15/170 (8%)
Query: 347 ALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEAR 406
AL K+NT++ + I EE+E K++ + L++ + + A+ +L + +
Sbjct: 1366 ALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEE-HVEAVNAKCASLEKTK 1424
Query: 407 KHLKEETQ-LRLDVEKELEMQISMRQEMELAMKMLE--KDVCEKQDALVSLRQQLDDLRA 463
+ L+ E + L LDVE+ ++ ++ K+L K CE+ A + Q+ + R+
Sbjct: 1425 QRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQK--EARS 1482
Query: 464 LKHELAFKLQSS--------DLGVKQKSELNSRLEEKTNQMAATIKQLEQ 505
L EL FK++++ + ++ L + + T Q+A K++ +
Sbjct: 1483 LGTEL-FKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHE 1531
Score = 31.6 bits (70), Expect = 1.8
Identities = 28/160 (17%), Positives = 71/160 (44%), Gaps = 15/160 (9%)
Query: 360 AVANNRIITLQEEMERVKEESSYILESNRKGPKQDRT--------------AEGQALSEA 405
A + T++EE +++K+E + E+ RK ++ AE + L++A
Sbjct: 849 AETEKEMATMKEEFQKIKDELAKS-EAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADA 907
Query: 406 RKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALK 465
+ + + ++ +E +++ ++ E L + +D L++ +DDL
Sbjct: 908 EERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 967
Query: 466 HELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQ 505
++ + +++ VK +E + L+E ++ K L++
Sbjct: 968 AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQE 1007
Score = 31.2 bits (69), Expect = 2.3
Identities = 40/176 (22%), Positives = 76/176 (43%), Gaps = 17/176 (9%)
Query: 324 KNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYI 383
+N VE+L + T A AL+K + LA + E+E ++E+ +
Sbjct: 1428 QNEVEDLMLDVERT----NAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSL 1483
Query: 384 LES--NRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLE 441
K ++ + + L K+L++E D+ +++ E+E K +E
Sbjct: 1484 GTELFKIKNAYEESLDQLETLKRENKNLQQEIS---DLTEQIAEGGKRIHELEKIKKQVE 1540
Query: 442 KDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQ-KSELNSRLEEKTNQM 496
++ CE Q AL +L+HE K+ L + Q KSE++ ++ EK ++
Sbjct: 1541 QEKCELQAALEEAE------ASLEHEEG-KILRIQLELNQVKSEVDRKIAEKDEEI 1589
>gi|40538728 pleckstrin homology domain containing, family M (with
RUN domain) member 1 [Homo sapiens]
Length = 1056
Score = 58.2 bits (139), Expect = 2e-08
Identities = 48/167 (28%), Positives = 73/167 (43%), Gaps = 20/167 (11%)
Query: 139 SIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFL---GQNKS------- 188
S+K L + ++L + S+ +E HGL AK G+ K
Sbjct: 25 SVKALQKQYVSLDTVVTSEDGDANTMCSALEAVFIHGLHAKHIRAEAGGKRKKSAHQKPL 84
Query: 189 ----FWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALI 244
FW L+ V I + ++ L + T VGR RAWLRLAL + Y+K L+
Sbjct: 85 PQPVFWPLLKAVTH-----KHIISELEHLTFVNTDVGRCRAWLRLALNDGLMECYLKLLL 139
Query: 245 NKKELLSEFYEPNALMME-EEGAIIAGLLVGLNVIDANFCMKGEDLD 290
++ L E+Y+P AL+ + EEG + L GL + K L+
Sbjct: 140 QEQARLHEYYQPTALLRDAEEGEFLLSFLQGLTSLSFELSYKSAILN 186
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 58.2 bits (139), Expect = 2e-08
Identities = 45/205 (21%), Positives = 92/205 (44%), Gaps = 13/205 (6%)
Query: 314 DGQITAILDQKNYVEELNRHLNATVNNLQAK-------VDALEKSNTKLTEELAVANNRI 366
+ ++ + ++ EE+N L A NL+ K +D LE + TK+ +E N++
Sbjct: 920 EAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKV 979
Query: 367 ITLQEEMERVKEESSYI------LESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVE 420
L EEM ++E S + L+ + D E ++ K + Q D+E
Sbjct: 980 KNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLE 1039
Query: 421 KELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVK 480
LE + +R ++E A + LE D+ Q++++ L + + F+L +
Sbjct: 1040 GSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKID 1099
Query: 481 QKSELNSRLEEKTNQMAATIKQLEQ 505
+ + + ++K ++ A I++LE+
Sbjct: 1100 DEQVHSLQFQKKIKELQARIEELEE 1124
Score = 55.8 bits (133), Expect = 9e-08
Identities = 66/286 (23%), Positives = 133/286 (46%), Gaps = 39/286 (13%)
Query: 234 KKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLV------GLNVIDANFCMKGE 287
K LSE M AL +E +S+ + + E + L V GL I+A + +
Sbjct: 980 KNLSEEMTAL---EENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTD 1036
Query: 288 DLDSQVGVIDFSMYLKDG--NSSKGTEGDGQIT--AILDQKN---YVEELNRHLNATVNN 340
DL+ G ++ L+ + + EGD +++ +I+D +N +EE + ++
Sbjct: 1037 DLE---GSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQ 1093
Query: 341 LQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQ 400
LQAK+D + + + +++ RI L+EE+ E+ + L + + + D E +
Sbjct: 1094 LQAKIDDEQVHSLQFQKKIKELQARIEELEEEI-----EAEHTLRAKIEKQRSDLARELE 1148
Query: 401 ALSEARKHLKEETQLRLDVEKELEMQI-SMRQEMELAMKMLEKDVC----EKQDALVSLR 455
+SE + T ++++ K+ E + MR+++E A E ++ D++ L
Sbjct: 1149 EISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELG 1208
Query: 456 QQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIK 501
+Q+D+L+ +K +L K+KSEL +++ + + A K
Sbjct: 1209 EQIDNLQRVKQKLE----------KEKSELKMEIDDMASNIEALSK 1244
Score = 46.6 bits (109), Expect = 5e-05
Identities = 44/180 (24%), Positives = 84/180 (46%), Gaps = 23/180 (12%)
Query: 340 NLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEG 399
NL K+ L KS A A + T++E+ ER KEE + E+ RK ++ +
Sbjct: 835 NLFFKIKPLLKS--------AEAEKEMATMKEDFERTKEELARS-EARRKELEEKMVSLL 885
Query: 400 QALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQ----------- 448
Q ++ + ++ ET+ +D E+ E I + +E +K L + + E++
Sbjct: 886 QEKNDLQLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKR 945
Query: 449 ---DALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQ 505
D SL++ +DDL ++ + +++ VK SE + LEE +++ K L++
Sbjct: 946 NLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQE 1005
Score = 43.1 bits (100), Expect = 6e-04
Identities = 52/231 (22%), Positives = 103/231 (44%), Gaps = 28/231 (12%)
Query: 289 LDSQVGVIDFSMYLKDGNSSKGTEGD-GQITAILDQKN-YVEELNRHLNATVNNL---QA 343
LD+++ + ++ LK K EGD ++ L N + E +HL L Q
Sbjct: 1605 LDAEIRSRNDALRLK-----KKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQL 1659
Query: 344 KVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQ-----DRT-- 396
+D +SN L E+LA+ R L EE+E +K + R ++ DR
Sbjct: 1660 HLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQL 1719
Query: 397 --AEGQALSEARKHLKEE-TQLRLDVEKELEMQISMRQEMELAM---KMLEKDVCEKQDA 450
++ +L +K L+ + Q + +VE ++ + ++ + A+ M+ +++ ++QD
Sbjct: 1720 LHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDT 1779
Query: 451 LVSLRQQLDDLRALKHELAFKLQSSDL-----GVKQKSELNSRLEEKTNQM 496
L + +L +L +L ++ G KQ +L +R+ E N++
Sbjct: 1780 SAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENEL 1830
Score = 36.2 bits (82), Expect = 0.072
Identities = 34/150 (22%), Positives = 74/150 (49%), Gaps = 18/150 (12%)
Query: 342 QAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQA 401
QA+++A +K + L+ EL N + +++E ++ E+ + E +Q
Sbjct: 1468 QAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQ-------- 1519
Query: 402 LSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDL 461
++E K+L+E + + VE+E + ++++A++ +E + ++ + LR QL +L
Sbjct: 1520 IAETGKNLQEAEKTKKLVEQE-------KSDLQVALEEVEGSLEHEESKI--LRVQL-EL 1569
Query: 462 RALKHELAFKLQSSDLGVKQKSELNSRLEE 491
+K EL K+ D ++Q + R E
Sbjct: 1570 SQVKSELDRKVIEKDEEIEQLKRNSQRAAE 1599
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 57.0 bits (136), Expect = 4e-08
Identities = 47/209 (22%), Positives = 101/209 (48%), Gaps = 21/209 (10%)
Query: 314 DGQITAILDQKNYVEELNRHLNATVNNLQAK-------VDALEKSNTKLTEELAVANNRI 366
+ +I + ++ EE+N L A L+ + +D LE + K+ +E N++
Sbjct: 920 EAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV 979
Query: 367 ITLQEEM-------ERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDV 419
L EEM ++ +E + E++++ + E + + + +K E Q+ D+
Sbjct: 980 KNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVD-DL 1038
Query: 420 EKELEMQISMRQEMELAMKMLEKDVCEKQDALVSL---RQQLDDLRALKHELAFKLQSSD 476
E LE + +R ++E A + LE D+ Q++ + + +QQLD+ K F++
Sbjct: 1039 EGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKE---FEMSGLQ 1095
Query: 477 LGVKQKSELNSRLEEKTNQMAATIKQLEQ 505
++ + L +L++K ++ A I++LE+
Sbjct: 1096 SKIEDEQALGMQLQKKIKELQARIEELEE 1124
Score = 45.4 bits (106), Expect = 1e-04
Identities = 45/204 (22%), Positives = 97/204 (47%), Gaps = 33/204 (16%)
Query: 312 EGDGQIT--AILDQKNYVEELNRHLNAT---VNNLQAKVDALEKSNTKLTEELAVANNRI 366
EGD ++ + +D +N ++L+ L ++ LQ+K++ + +L +++ RI
Sbjct: 1060 EGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARI 1119
Query: 367 ITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKE-----ETQLRLDVEK 421
L+EE+E + ++R ++ R+ + L E + L+E Q+ ++ ++
Sbjct: 1120 EELEEEIEAER--------ASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKR 1171
Query: 422 ELEMQISMRQEMELAMKMLEKDVC----EKQDALVSLRQQLDDLRALKHELAFKLQSSDL 477
E E Q MR+++E A E + D++ L +Q+D+L+ +K +L
Sbjct: 1172 EAEFQ-KMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLE-------- 1222
Query: 478 GVKQKSELNSRLEEKTNQMAATIK 501
K+KSE+ +++ + M K
Sbjct: 1223 --KEKSEMKMEIDDLASNMETVSK 1244
Score = 43.5 bits (101), Expect = 5e-04
Identities = 62/285 (21%), Positives = 114/285 (40%), Gaps = 49/285 (17%)
Query: 246 KKELLSEFYEPNALMMEEEGAIIAGLLVGLNVI----DANFCMKGEDLD----------- 290
K EL + E A + EEG I+ + + LN + D K E++D
Sbjct: 1541 KSELQAALEEAEASLEHEEGKILR-IQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVE 1599
Query: 291 SQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELN-------RHLNATVNNLQA 343
S +D + ++ + +G + + Q N+ + R+ A + + Q
Sbjct: 1600 SMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQL 1659
Query: 344 KVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQAL- 402
+D +S L E+LA+ R LQ E+E ++ LE + K AE + L
Sbjct: 1660 HLDDALRSQEDLKEQLAMVERRANLLQAEIEELRA----TLEQTERSRK---IAEQELLD 1712
Query: 403 -SEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDL 461
SE + L + ++ +K+LE IS Q +E + E ++A ++ + D
Sbjct: 1713 ASERVQLLHTQNTSLINTKKKLETDISQIQ------GEMEDIIQEARNAEEKAKKAITDA 1766
Query: 462 RALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQR 506
+ EL K++ + ++ LE + T+K L+ R
Sbjct: 1767 AMMAEEL-----------KKEQDTSAHLERMKKNLEQTVKDLQHR 1800
Score = 35.8 bits (81), Expect = 0.094
Identities = 35/177 (19%), Positives = 73/177 (41%), Gaps = 14/177 (7%)
Query: 344 KVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKG------------P 391
+V L NT L I +Q EME + +E+ E +K
Sbjct: 1716 RVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKK 1775
Query: 392 KQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMR--QEMELAMKMLEKDVCEKQD 449
+QD +A + + + + ++ Q RLD ++L ++ + Q++E ++ LE +V +Q
Sbjct: 1776 EQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQK 1835
Query: 450 ALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQR 506
V + L EL ++ + + + +L +L+ K ++ E++
Sbjct: 1836 RNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQ 1892
Score = 32.0 bits (71), Expect = 1.4
Identities = 29/160 (18%), Positives = 69/160 (43%), Gaps = 15/160 (9%)
Query: 360 AVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDV 419
A + ++EE E+ KEE + E+ RK ++ Q ++ + ++ E D
Sbjct: 847 AETEKEMANMKEEFEKTKEELAKT-EAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADA 905
Query: 420 EKELEMQISMRQEMELAMKMLEKDVCEKQ--------------DALVSLRQQLDDLRALK 465
E+ + I + ++E +K + + +++ D L++ +DDL
Sbjct: 906 EERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 965
Query: 466 HELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQ 505
++ + +++ VK +E + L+E ++ K L++
Sbjct: 966 AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQE 1005
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 55.8 bits (133), Expect = 9e-08
Identities = 46/208 (22%), Positives = 97/208 (46%), Gaps = 19/208 (9%)
Query: 314 DGQITAILDQKNYVEELN-------RHLNATVNNLQAKVDALEKSNTKLTEELAVANNRI 366
+G++ + ++ EE+N R L L+ +D L+ + K +E N++
Sbjct: 965 EGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKV 1024
Query: 367 ITLQEEM-------ERVKEESSYILESNRK--GPKQDRTAEGQALSEARKHLKEETQLRL 417
L EEM R+ +E + E++++ G Q AL++A+ L+++ +
Sbjct: 1025 KNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVE--- 1081
Query: 418 DVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDL 477
D+E LE + +R + E A + LE D+ Q+++ Q L + +L L
Sbjct: 1082 DLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSL 1141
Query: 478 GVKQKSELNSRLEEKTNQMAATIKQLEQ 505
V+ + L +++++K ++ A ++LE+
Sbjct: 1142 RVEDEQLLGAQMQKKIKELQARAEELEE 1169
Score = 40.4 bits (93), Expect = 0.004
Identities = 52/202 (25%), Positives = 91/202 (45%), Gaps = 19/202 (9%)
Query: 319 AILDQKNYVEELNRHLNATVNN---LQAKVDALEKSNTKLTEELAVANNRIITLQEEMER 375
A+ +++ EE+ R L A L ++ L + + E L LQEE+
Sbjct: 1501 ALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISD 1560
Query: 376 VKEESSYILESNRKGPKQDRTAEGQALSEARKHLKE-ETQLRLDVEKELEMQISMRQ-EM 433
+ ++ S +S ++ K + EG+ SE + L+E E L L+ K L +Q+ + Q +
Sbjct: 1561 LTDQVSLSGKSIQELEKTKKALEGEK-SEIQAALEEAEGALELEETKTLRIQLELSQVKA 1619
Query: 434 ELAMKMLEKD-VC-----EKQDALVSLRQQLD-DLRA------LKHELAFKLQSSDLGVK 480
E+ K+ EKD C Q A+ SL+ LD + RA LK ++ L +L +
Sbjct: 1620 EVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLG 1679
Query: 481 QKSELNSRLEEKTNQMAATIKQ 502
+ + + T M A +K+
Sbjct: 1680 HATRQATEAQAATRLMQAQLKE 1701
Score = 39.3 bits (90), Expect = 0.009
Identities = 41/187 (21%), Positives = 84/187 (44%), Gaps = 31/187 (16%)
Query: 324 KNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYI 383
K E+L R ++ + KV+ L++ + + R+ T E+ R+ EE +
Sbjct: 1291 KASAEKLCRTYEDQLSEAKIKVEELQRQ----LADASTQRGRLQTESGELSRLLEEKECL 1346
Query: 384 LESNRKGPKQDRTAEGQALSEARKHLKEETQ-----------LRLDVE---KELEMQISM 429
+ +G + Q+L E R+ L+EE++ LR D + ++ E +
Sbjct: 1347 ISQLSRG----KALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEA 1402
Query: 430 RQEMELAMKMLEKDVCE-----KQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSE 484
+ E++ + +V + + DA+ Q+ ++L K +LA +LQ ++ GV+ +
Sbjct: 1403 QAELQRLLSKANAEVAQWRSKYEADAI----QRTEELEEAKKKLALRLQEAEEGVEAANA 1458
Query: 485 LNSRLEE 491
S LE+
Sbjct: 1459 KCSSLEK 1465
Score = 36.2 bits (82), Expect = 0.072
Identities = 58/284 (20%), Positives = 115/284 (40%), Gaps = 48/284 (16%)
Query: 231 LMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLD 290
LMQ +L E ++ L +E +E A +E +++A L E+L
Sbjct: 1694 LMQAQLKEEQAGRDEEQRLAAELHE-QAQALERRASLLAAEL--------------EELR 1738
Query: 291 SQVGVIDFSMYLKDGNSSKGTEG----DGQITAILDQKNYVEELNRHLNATVNNL-QAKV 345
+ + + S L + + TE Q T +L+QK +E L+ V Q +
Sbjct: 1739 AALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERR 1798
Query: 346 DALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEA 405
+A EK+ +T+ +A E +K+E QD +A + + +
Sbjct: 1799 EAEEKAKKAITDAAMMA-----------EELKKE-------------QDTSAHLERMKKT 1834
Query: 406 RKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDV---CEKQDALVSLRQQLDDLR 462
+ E Q RL+ ++ ++ +Q +L K+ E + E++ +L+ R
Sbjct: 1835 LEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHER 1894
Query: 463 ALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQR 506
+K ELA++ + + + +L +L+ K ++ EQ+
Sbjct: 1895 RVK-ELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQ 1937
Score = 33.5 bits (75), Expect = 0.47
Identities = 39/196 (19%), Positives = 89/196 (45%), Gaps = 12/196 (6%)
Query: 316 QITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMER 375
+I+ + DQ + + + L T L+ + ++ + + L + + + +Q E+ +
Sbjct: 1557 EISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQ 1616
Query: 376 VKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLR---LDVEKELEMQISMRQE 432
VK E L + R +A+ + L ET+ R L ++K++E ++ +
Sbjct: 1617 VKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLN---D 1673
Query: 433 MELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHE---LAFKLQSSDLGVKQKSELNSRL 489
+EL + + E Q A ++ QL + +A + E LA +L +++++ L L
Sbjct: 1674 LELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASL---L 1730
Query: 490 EEKTNQMAATIKQLEQ 505
+ ++ A ++Q E+
Sbjct: 1731 AAELEELRAALEQGER 1746
Score = 31.2 bits (69), Expect = 2.3
Identities = 62/327 (18%), Positives = 135/327 (41%), Gaps = 59/327 (18%)
Query: 235 KLSEYMKALINKKELLSEFYEPNALMME-EEGAIIAGLLVGLNVIDANFCMKGEDL--DS 291
+L E + +L ++ L + E + L ME ++ A L C ED ++
Sbjct: 1251 ELGEQVDSLQRVRQKLEK--EKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEA 1308
Query: 292 QVGVIDFSMYLKDGNSSKG---TEGDGQITAILDQKN-YVEELNRHLNATVNNLQAKVDA 347
++ V + L D ++ +G TE G+++ +L++K + +L+R +L+
Sbjct: 1309 KIKVEELQRQLADASTQRGRLQTES-GELSRLLEEKECLISQLSRGKALAAQSLEELRRQ 1367
Query: 348 LE---KSNTKLTEELAVANNRIITLQE----------EMERVKEESSYILESNRKGPKQD 394
LE K+ + L + + L+E E++R+ +++ + R + D
Sbjct: 1368 LEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEAD 1427
Query: 395 RTAEGQALSEARKHLK--------------------EETQLRL-----DVEKELEMQISM 429
+ L EA+K L E+ +LRL DV ELE S
Sbjct: 1428 AIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSA 1487
Query: 430 RQEMELAMKMLEKDVCEKQDALVSLRQQLD-----------DLRALKHELAFKLQSSDLG 478
++ + LE+ + E++ ++++L+ +L L+H L++ +
Sbjct: 1488 AAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETL 1547
Query: 479 VKQKSELNSRLEEKTNQMAATIKQLEQ 505
++ L + + T+Q++ + K +++
Sbjct: 1548 KRENKNLQEEISDLTDQVSLSGKSIQE 1574
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 55.5 bits (132), Expect = 1e-07
Identities = 44/192 (22%), Positives = 91/192 (47%), Gaps = 15/192 (7%)
Query: 328 EELNRHLNATVNNLQAK-------VDALEKSNTKLTEELAVANNRIITLQEEM------- 373
EE+N L A L+ + +D LE + K+ +E N++ L EEM
Sbjct: 932 EEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEII 991
Query: 374 ERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEM 433
++ +E + E++++ + E + S ++ +K E Q+ D+E LE + +R ++
Sbjct: 992 AKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVD-DLEGSLEQEKKVRMDL 1050
Query: 434 ELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKT 493
E A + LE D+ Q++++ L L + F + + ++ + L +L++K
Sbjct: 1051 ERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKL 1110
Query: 494 NQMAATIKQLEQ 505
+ A I++LE+
Sbjct: 1111 KENQARIEELEE 1122
Score = 41.6 bits (96), Expect = 0.002
Identities = 45/192 (23%), Positives = 87/192 (45%), Gaps = 19/192 (9%)
Query: 327 VEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRI-------ITLQEEMERVKEE 379
VE N L A + L+A V+ E+S +EL + R+ +L + ++++ +
Sbjct: 1676 VERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESD 1735
Query: 380 SSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQI---SMRQEMELA 436
+ + + ++ R AE +A+K + + + +++KE + M++ ME
Sbjct: 1736 LTQLQSEVEEAVQECRNAE----EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQT 1791
Query: 437 MKMLEKDVCE-KQDALVSLRQQLDDLRALKHELAFKLQSSDL----GVKQKSELNSRLEE 491
+K L+ + E +Q AL ++QL L A EL +L++ VK + R++E
Sbjct: 1792 IKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKE 1851
Query: 492 KTNQMAATIKQL 503
T Q K L
Sbjct: 1852 LTYQTEEDKKNL 1863
Score = 38.1 bits (87), Expect = 0.019
Identities = 42/226 (18%), Positives = 95/226 (42%), Gaps = 43/226 (19%)
Query: 320 ILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEE 379
I+ K +E+++R L N + K++ ++S T + A ++ T E+ R EE
Sbjct: 1240 IIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRA----KLQTENGELARQLEE 1295
Query: 380 SSYILESNRKGP----------KQDRTAEGQA---LSEA-----------RKHLKEETQL 415
++ +G K+ EG+A L+ A R+ +EET+
Sbjct: 1296 KEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEA 1355
Query: 416 RLDVEKELEMQ---------------ISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDD 460
+ ++++ L I +E+E A K L + + + ++A+ ++ +
Sbjct: 1356 KAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSS 1415
Query: 461 LRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQR 506
L KH L +++ + V++ + + L++K + + +Q+
Sbjct: 1416 LEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQK 1461
Score = 36.2 bits (82), Expect = 0.072
Identities = 38/182 (20%), Positives = 77/182 (42%), Gaps = 13/182 (7%)
Query: 327 VEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILES 386
+E++ + L LQ+ ALE++ L E +I+ Q E ++K E L
Sbjct: 1528 LEKVRKQLEVEKLELQS---ALEEAEASLEHE----EGKILRAQLEFNQIKAEIERKLAE 1580
Query: 387 NRKGPKQDRTAEGQALSEARKHLKEETQLR---LDVEKELEMQISMRQEMELAMKMLEKD 443
+ +Q + + + + L ET+ R L V+K++E ++ EME+ + +
Sbjct: 1581 KDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLN---EMEIQLSHANRM 1637
Query: 444 VCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQL 503
E Q + SL+ L D + + + N+ L+ + ++ A ++Q
Sbjct: 1638 AAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQT 1697
Query: 504 EQ 505
E+
Sbjct: 1698 ER 1699
Score = 33.1 bits (74), Expect = 0.61
Identities = 41/197 (20%), Positives = 89/197 (45%), Gaps = 28/197 (14%)
Query: 322 DQKNYVEELNRHLNATVNNLQAKVDA-------LEKSNTKLTEELAVANNRIITLQEEM- 373
D+ N + + L V++L+ ++ LE++ KL +L + I+ L+ +
Sbjct: 1017 DKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKL 1076
Query: 374 ---ERVKEESSYILESNRKGPKQDRTAEGQALS-EARKHLKEETQLRLDVEKELEMQISM 429
E++K++ I + N K + Q L+ + +K LKE ++E+ELE + +
Sbjct: 1077 QLEEKLKKKEFDINQQNSK------IEDEQVLALQLQKKLKENQARIEELEEELEAERTA 1130
Query: 430 RQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRL 489
R ++E L D+ + + + ++ +++ E+ K ++ + ++ L
Sbjct: 1131 RAKVE----KLRSDLSRELEEISERLEEAGGATSVQIEMNKKREA------EFQKMRRDL 1180
Query: 490 EEKTNQMAATIKQLEQR 506
EE T Q AT L ++
Sbjct: 1181 EEATLQHEATAAALRKK 1197
Score = 31.2 bits (69), Expect = 2.3
Identities = 32/136 (23%), Positives = 59/136 (43%), Gaps = 29/136 (21%)
Query: 370 QEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISM 429
++EM +KEE I E+ K SEAR+ EE + L EK ++Q+ +
Sbjct: 848 EKEMATMKEEFGRIKETLEK-------------SEARRKELEEKMVSLLQEKN-DLQLQV 893
Query: 430 RQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRL 489
+ E QD L ++ D L K +L K++ + ++ + E+N+ L
Sbjct: 894 QAE---------------QDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAEL 938
Query: 490 EEKTNQMAATIKQLEQ 505
K ++ +L++
Sbjct: 939 TAKKRKLEDECSELKK 954
Score = 29.3 bits (64), Expect = 8.8
Identities = 31/162 (19%), Positives = 72/162 (44%), Gaps = 19/162 (11%)
Query: 360 AVANNRIITLQEEMERVKE--ESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRL 417
A + T++EE R+KE E S E+ RK ++ + Q ++ + ++ E
Sbjct: 845 AETEKEMATMKEEFGRIKETLEKS---EARRKELEEKMVSLLQEKNDLQLQVQAEQDNLN 901
Query: 418 DVEKELEMQISMRQEMELAMKMLEKDVCEKQ--------------DALVSLRQQLDDLRA 463
D E+ + I + ++E +K + + + +++ D L++ +DDL
Sbjct: 902 DAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLEL 961
Query: 464 LKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQ 505
++ + +++ VK +E + L+E ++ K L++
Sbjct: 962 TLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQE 1003
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 54.7 bits (130), Expect = 2e-07
Identities = 35/149 (23%), Positives = 78/149 (52%), Gaps = 10/149 (6%)
Query: 322 DQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESS 381
++ ++ + + A + +L+ ++D E + KL E A +I ++EE+ +++++S
Sbjct: 936 ERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNS 995
Query: 382 YILESNRKGPKQDRTAE-GQALSEARKHLKEETQLR-------LDVEKELEMQISMRQEM 433
++ + +DR AE L+E + K ++R D+E+ L+ + RQE+
Sbjct: 996 KFIKEKKL--MEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQEL 1053
Query: 434 ELAMKMLEKDVCEKQDALVSLRQQLDDLR 462
E A + L+ + + QD + L+ Q+D+L+
Sbjct: 1054 EKAKRKLDGETTDLQDQIAELQAQIDELK 1082
Score = 52.8 bits (125), Expect = 7e-07
Identities = 55/215 (25%), Positives = 98/215 (45%), Gaps = 25/215 (11%)
Query: 303 KDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVA 362
K G + E ++ + K E + L+A V L AKV ++ +L E+ +
Sbjct: 1226 KQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKAS-- 1283
Query: 363 NNRIITLQEEMERVKEESSYILESNRKGPK--QDRTAEGQALSEARKHLKEETQLRLDV- 419
LQ E++ V S+ + E+ +KG K +D + L + ++ L+EET+ +L++
Sbjct: 1284 -----KLQNELDNV---STLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLS 1335
Query: 420 ------EKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQ 473
E+E ++E E A K LEK V Q L ++++DD L +
Sbjct: 1336 SRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLE---E 1392
Query: 474 SSDLGVKQKSELNSRLEEKT---NQMAATIKQLEQ 505
+ +K L+ RLEEK +++ T +L+Q
Sbjct: 1393 AKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQ 1427
Score = 47.8 bits (112), Expect = 2e-05
Identities = 44/200 (22%), Positives = 92/200 (46%), Gaps = 16/200 (8%)
Query: 321 LDQKNYVEELNRHLNATVNNLQAKVD-------ALEKSNTKLTEELAVANNRIITLQEEM 373
L+ K E N+ L A + +L + D LEKS L +++ ++ L++E+
Sbjct: 1496 LEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDEL 1555
Query: 374 ERVKEESSYILESNRKGPKQD-----RTAEGQALSEARKHLKEETQLRLDVE---KELEM 425
+ E++ LE N + K +T + Q + R +K+ +L ++E K+ +
Sbjct: 1556 QAT-EDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRAL 1614
Query: 426 QISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSEL 485
++ +++ME+ +K LE + A + +QL L+A + +L+ + +
Sbjct: 1615 AVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQ 1674
Query: 486 NSRLEEKTNQMAATIKQLEQ 505
+ E+K + A I QL++
Sbjct: 1675 SKESEKKLKSLEAEILQLQE 1694
Score = 40.4 bits (93), Expect = 0.004
Identities = 41/201 (20%), Positives = 92/201 (45%), Gaps = 14/201 (6%)
Query: 316 QITAILDQKNYVEELNRHLNATVNNLQAKVDA-LEKSNTKLTEELAVANNRIITLQEEME 374
Q+ + D+ E+ L + ++A+ + L+ + + E+ + ++ L+ E+E
Sbjct: 1547 QLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELE 1606
Query: 375 RVKEESSYILESNRKGP--KQDRTAEGQALSEAR----KHLKEETQLRLDVEKELEMQIS 428
+++ + + S +K +D A+ +A ++AR K L++ D ++ELE +
Sbjct: 1607 DERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARA 1666
Query: 429 MRQEM-------ELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQ 481
R E+ E +K LE ++ + Q+ L S + + ELA ++ +S G
Sbjct: 1667 SRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSA 1726
Query: 482 KSELNSRLEEKTNQMAATIKQ 502
+ RLE + Q+ +++
Sbjct: 1727 LLDEKRRLEARIAQLEEELEE 1747
Score = 38.9 bits (89), Expect = 0.011
Identities = 38/168 (22%), Positives = 76/168 (45%), Gaps = 22/168 (13%)
Query: 353 TKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEE 412
T+ EEL + ++ ++E+ +V+ E + E RK Q E L+E L+ E
Sbjct: 848 TRQEEELQAKDEELLKVKEKQTKVEGE---LEEMERK--HQQLLEEKNILAE---QLQAE 899
Query: 413 TQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDA--------------LVSLRQQL 458
T+L + E+ + +QE+E + LE V E+++ + L +QL
Sbjct: 900 TELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQL 959
Query: 459 DDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQR 506
D+ + +L + +++ +K+ E LE++ ++ K +E R
Sbjct: 960 DEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDR 1007
Score = 35.8 bits (81), Expect = 0.094
Identities = 34/183 (18%), Positives = 74/183 (40%), Gaps = 7/183 (3%)
Query: 327 VEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERV---KEESSYI 383
V+E + + ++ K L + L E+L +E R+ K+E I
Sbjct: 864 VKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEI 923
Query: 384 LESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKD 443
L + + ++ Q L +K ++ Q D+E++L+ + RQ+++L E
Sbjct: 924 LH-DLESRVEEEEERNQILQNEKKKMQAHIQ---DLEEQLDEEEGARQKLQLEKVTAEAK 979
Query: 444 VCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQL 503
+ + ++ ++ L Q K + ++ + ++ E L + N+ I L
Sbjct: 980 IKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDL 1039
Query: 504 EQR 506
E+R
Sbjct: 1040 EER 1042
Score = 35.8 bits (81), Expect = 0.094
Identities = 42/201 (20%), Positives = 86/201 (42%), Gaps = 9/201 (4%)
Query: 314 DGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEM 373
+ +I + ++ E RH + L ++ + L +E RI L+EE+
Sbjct: 1686 EAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEEL 1745
Query: 374 ERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEM 433
E + + + RK Q T + +E R ++ R +E++ + + QE+
Sbjct: 1746 EEEQSNMELLNDRFRKTTLQVDTLNAELAAE-RSAAQKSDNARQQLERQNKELKAKLQEL 1804
Query: 434 ELAMKMLEKDVCEKQDALV-SLRQQLDD---LRALKHELA----FKLQSSDLGVKQKSEL 485
E A+K K +A + L +QL+ RA ++L KL+ + V+ +
Sbjct: 1805 EGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRH 1864
Query: 486 NSRLEEKTNQMAATIKQLEQR 506
+ +E+ + A +KQL+++
Sbjct: 1865 ADQYKEQMEKANARMKQLKRQ 1885
Score = 31.2 bits (69), Expect = 2.3
Identities = 39/218 (17%), Positives = 85/218 (38%), Gaps = 20/218 (9%)
Query: 307 SSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAK--------------VDALEKSN 352
SS+ + + + ++ +Q+ EE ++L V LQ++ +++LE++
Sbjct: 1335 SSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAK 1394
Query: 353 TKLTEELAVANNRI---ITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKH- 408
KL ++ + R+ +++E+ K L+ R + +K
Sbjct: 1395 KKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFD 1454
Query: 409 --LKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKH 466
L EE + +E + + +E E L + + E +A +Q LRA
Sbjct: 1455 QLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADME 1514
Query: 467 ELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLE 504
+L V + + LE++ +M +++LE
Sbjct: 1515 DLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELE 1552
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 53.9 bits (128), Expect = 3e-07
Identities = 52/218 (23%), Positives = 104/218 (47%), Gaps = 18/218 (8%)
Query: 302 LKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTE---E 358
LK + E + Q I + ++ +E + +L+ +++ L LTE E
Sbjct: 39 LKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKE 98
Query: 359 LAVANNRIITLQEEMERVKEESSYILESNRKG---PKQDRTAEGQALSEARKHLKEETQL 415
L +A +R I +Q + R KEE LE+ ++ + + E + L+E K L E+ +
Sbjct: 99 LEIAQDRNIAIQSQFTRTKEE----LEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKE 154
Query: 416 RLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVS--------LRQQLDDLRALKHE 467
+ EL++++ Q ++++K EK + ++++ L S L+ + D+L AL E
Sbjct: 155 SNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGRE 214
Query: 468 LAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQ 505
++ ++ K E SRLEE+ N + + + L++
Sbjct: 215 KGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQK 252
Score = 43.5 bits (101), Expect = 5e-04
Identities = 39/170 (22%), Positives = 88/170 (51%), Gaps = 7/170 (4%)
Query: 335 NATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQD 394
N + LQ +V L NTK++ +L A+ R LQ+ +E + E + + E N+K
Sbjct: 694 NEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATT 753
Query: 395 RTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSL 454
+ E Q ++ + L+ + E E ++++E E+ +K+ E + +++++L++
Sbjct: 754 QKQE-QIINTMTQDLRGANEKLAVAEVRAE---NLKKEKEM-LKLSEVRLSQQRESLLAE 808
Query: 455 RQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLE 504
++ + L + L+ S+ KQ+ L+S++E+ ++++ K+LE
Sbjct: 809 QRGQNLLLTNLQTIQGILERSETETKQR--LSSQIEKLEHEISHLKKKLE 856
Score = 41.2 bits (95), Expect = 0.002
Identities = 71/335 (21%), Positives = 144/335 (42%), Gaps = 51/335 (15%)
Query: 193 LELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALINKKELLSE 252
+E + KL+ EA E +++D V + + + +++K + K L N +LLS
Sbjct: 307 VEELHKLLKEAGEANKAIQDH---LLEVEQSKDQMEKEMLEK-IGRLEKELENANDLLSA 362
Query: 253 FYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGTE 312
A++ EEE A ++ + A G L ++ Y++ +
Sbjct: 363 TKRKGAILSEEELAAMSPTAAAV----AKIVKPGMKLTEL-----YNAYVETQDQ----- 408
Query: 313 GDGQITAILDQKNYVEELNRHLNATVNNLQAKVDAL----------EKSNTKLTEELAVA 362
+L +K + +N++L+ V ++AK L +K+ L+ +L A
Sbjct: 409 -------LLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQA 461
Query: 363 NNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQ------ALSEARKH--LKEETQ 414
I LQE+ ++ ++SS + NR+ Q + Q L EAR + +++E
Sbjct: 462 MKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEV 521
Query: 415 LRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQS 474
D+ E+ + Q + ++ + +E+ + Q LV+LR +L + R + + +
Sbjct: 522 SSADISSSSEV---ISQHL-VSYRNIEELQQQNQRLLVALR-ELGETREREEQETTSSKI 576
Query: 475 SDLGVKQKS---ELNSRLEEKTNQMAATIKQLEQR 506
++L +K +S EL + + +QM + QR
Sbjct: 577 TELQLKLESALTELEQLRKSRQHQMQLVDSIVRQR 611
Score = 39.7 bits (91), Expect = 0.007
Identities = 47/210 (22%), Positives = 93/210 (44%), Gaps = 27/210 (12%)
Query: 320 ILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRII------------ 367
+L+ K EE R L V+ + + LEK N L +++ +++++
Sbjct: 1124 LLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLN 1183
Query: 368 -TLQEE---MERVKEESSYILESNRKGPKQDRTAEGQALS-----EARKHLKEETQLRLD 418
+L EE E++ E +I + A+ ++L E + +E Q L+
Sbjct: 1184 VSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLN 1243
Query: 419 VEKELEMQIS---MRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSS 475
E+E ++Q++ M Q EL K +V + + + LR++ + L ++ K++
Sbjct: 1244 AERE-KVQVTAKTMAQHEELMKKTETMNVVMETNKM--LREEKERLEQDLQQMQAKVRKL 1300
Query: 476 DLGVKQKSELNSRLEEKTNQMAATIKQLEQ 505
+L + E N+ L EK+ + A K LE+
Sbjct: 1301 ELDILPLQEANAELSEKSGMLQAEKKLLEE 1330
Score = 36.6 bits (83), Expect = 0.055
Identities = 37/177 (20%), Positives = 82/177 (46%), Gaps = 11/177 (6%)
Query: 335 NATVNNLQAKVDALEKSNTKL-TEELAVANN---RIITLQEEMERVKEESS----YILES 386
NA++ N Q + +L++ K+ TE+ + + +II +QE+++ + + Y +
Sbjct: 1386 NASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQY 1445
Query: 387 NRKGPKQDRTAEGQALSEARKHLKEETQLR--LDVEKELEMQISMRQEMELAMKMLEKDV 444
+QD+ E A S H ++ ++ ++++ L + + +E ++ L+K +
Sbjct: 1446 EELKAQQDKVMETSAQSSG-DHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTL 1504
Query: 445 CEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIK 501
EK+ +L++Q L++ L LQ +Q + + EEKT + K
Sbjct: 1505 SEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAK 1561
Score = 35.8 bits (81), Expect = 0.094
Identities = 79/376 (21%), Positives = 154/376 (40%), Gaps = 52/376 (13%)
Query: 152 RTLDSDYAPLQQFFVVMEHCLKHG-LKAKKTFLGQNKSFWGP-------------LELVE 197
R L+ D PLQ+ + K G L+A+K L ++ W E
Sbjct: 1298 RKLELDILPLQEANAELSE--KSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYR 1355
Query: 198 KLVPEAAEITASVKDLPG----LKTPVGRGRAWL--RLALMQKKLSEYMKALINKKELLS 251
KL+ E T ++ L LK + R A L L+Q L E + + +KE +
Sbjct: 1356 KLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQS-LKEDLNKVRTEKETIQ 1414
Query: 252 EFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGT 311
+ + + ++E+ I + I + + E+L +Q K +S +
Sbjct: 1415 KDLDAKIIDIQEKVKTITQV----KKIGRRYKTQYEELKAQQD--------KVMETSAQS 1462
Query: 312 EGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQE 371
GD Q +Q V+E+ + L T+N + K +LE L + L+ LQE
Sbjct: 1463 SGDHQ-----EQHVSVQEM-QELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQE 1516
Query: 372 EMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQ 431
+ +++ E S + + QDRT + + L + +E+T+ + K +I+
Sbjct: 1517 QTVQLQSELSRLRQD-----LQDRTTQEEQLRQQITEKEEKTRKAIVAAKS---KIAHLA 1568
Query: 432 EMELAMKMLEKDVCEKQDALVSLRQQLD-DLRALKHELAFKLQSSDLGVKQKSELNSRLE 490
++ + +++ ++ AL + +LD + ALK + ++ + +++ E LE
Sbjct: 1569 GVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQE--RHLE 1626
Query: 491 EKTNQMAATIKQLEQR 506
++ + K EQ+
Sbjct: 1627 QRDEPQEPSNKVPEQQ 1642
Score = 34.7 bits (78), Expect = 0.21
Identities = 48/223 (21%), Positives = 88/223 (39%), Gaps = 31/223 (13%)
Query: 302 LKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAV 361
LK+ N++KG ++ LD+ ++ + + L+ + + L NT L EL
Sbjct: 152 LKESNTTKG-----ELQLKLDE---LQASDVSVKYREKRLEQEKELLHSQNTWLNTELKT 203
Query: 362 ANNRIITLQEE-----------MERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLK 410
+ ++ L E +E KEE S LE G K + + + LK
Sbjct: 204 KTDELLALGREKGNEILELKCNLENKKEEVSR-LEEQMNGLKTSNEHLQKHVEDLLTKLK 262
Query: 411 EETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDL--------R 462
E + + +E++ +++ ++ K D K + L ++L L +
Sbjct: 263 EAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANK 322
Query: 463 ALKHELAFKLQSSDLGVKQKSELNSRLE---EKTNQMAATIKQ 502
A++ L QS D K+ E RLE E N + + K+
Sbjct: 323 AIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKR 365
>gi|27436951 lamin B2 [Homo sapiens]
Length = 600
Score = 53.1 bits (126), Expect = 6e-07
Identities = 52/214 (24%), Positives = 104/214 (48%), Gaps = 36/214 (16%)
Query: 320 ILDQKNYVEELNRH---LNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERV 376
+ D + ++E R L + L+A++D + KS K EL VA R+ L+ R
Sbjct: 80 LADARRVLDETARERARLQIEIGKLRAELDEVNKSAKKREGELTVAQGRVKDLESLFHRS 139
Query: 377 KEESSYILESNRKGPKQD---------RTAEGQALSEARKHLKEETQLRLDVEKELEMQI 427
+ E + L S+++G + D + +G A+ A+K L++ET +R+D+E +
Sbjct: 140 EVELAAAL-SDKRGLESDVAELRAQLAKAEDGHAV--AKKQLEKETLMRVDLENRCQ--- 193
Query: 428 SMRQEMELAMKMLEKDVCE----------------KQDALVSLRQQLDDLRALKHELAFK 471
S+++E++ + E++V E +Q+ + Q L++LR+ +H+ +
Sbjct: 194 SLQEELDFRKSVFEEEVRETRRRHERRLVEVDSSRQQEYDFKMAQALEELRS-QHDEQVR 252
Query: 472 LQSSDLGVKQKSELNS-RLEEKTNQMAATIKQLE 504
L +L +++L+S +L N AA+ + E
Sbjct: 253 LYKLELEQTYQAKLDSAKLSSDQNDKAASAAREE 286
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 52.8 bits (125), Expect = 7e-07
Identities = 42/167 (25%), Positives = 75/167 (44%), Gaps = 25/167 (14%)
Query: 311 TEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQ 370
++ +G I D+K E +Q K D +++ L +EL A+NR+ L+
Sbjct: 1918 SKAEGVIDGYADEKTLFER----------QIQEKTDIIDR----LEQELLCASNRLQELE 1963
Query: 371 EEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMR 430
E ++++EE + + E Q L E K +KE+ +++ EK +R
Sbjct: 1964 AEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEK-------VR 2016
Query: 431 QEMELAMKMLEKDVCEKQDALVSLRQ----QLDDLRALKHELAFKLQ 473
+++ +K LE DV E+ + L Q +L DLR L +L+
Sbjct: 2017 DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLE 2063
Score = 45.4 bits (106), Expect = 1e-04
Identities = 52/253 (20%), Positives = 115/253 (45%), Gaps = 35/253 (13%)
Query: 284 MKGEDLDSQVGVIDFSMYLKDGNSSKGTEG--------------DG---QITAILDQ--- 323
M+ E Q + + + L++ + GTEG DG Q+TA L Q
Sbjct: 160 MESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARR 219
Query: 324 ------KNYVE--ELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMER 375
+ ++E E ++ L LQA +++ +L A +I+T Q+++
Sbjct: 220 EKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQL-- 277
Query: 376 VKEESSYILESNRKGPKQDRTAEGQALSEARK--HLKEETQLRLDVEKELEMQISMRQEM 433
EE ++LE +K K+D T + L E K ++++ ++ ++E++ + ++ +E+
Sbjct: 278 --EEQDHLLEDYQK-KKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEEL 334
Query: 434 ELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKT 493
+ EK E +D L + + L +L+ + ++++ L + + + E+
Sbjct: 335 NTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEI 394
Query: 494 NQMAATIKQLEQR 506
Q+ T+++L++R
Sbjct: 395 KQLMGTVEELQKR 407
Score = 42.7 bits (99), Expect = 8e-04
Identities = 50/213 (23%), Positives = 91/213 (42%), Gaps = 37/213 (17%)
Query: 328 EELNRHLNATVNNLQAKVDALEKSNTKLTEELAVA-------NNRIITLQEEMERVKEES 380
++ +R L + +AK+ E+ + + E+L + N ++ L E+ +++ ES
Sbjct: 3214 QKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNES 3273
Query: 381 SYILESNRK------GPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQ--- 431
+ES R +Q R E Q L E+ K E LD E+EL Q+
Sbjct: 3274 QQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTG 3333
Query: 432 ------EMELAMKMLEKDVCEKQDALVSL--------------RQQLD-DLRALKHELAF 470
E +K L+K + EK +V L RQQ++ D + + L
Sbjct: 3334 QSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQT 3393
Query: 471 KLQSSDLGVKQKSELNSRLEEKTNQMAATIKQL 503
+ +++ G K+ EL S++E+ Q+ +Q+
Sbjct: 3394 EQEANTEGQKKMHELQSKVEDLQRQLEEKRQQV 3426
Score = 37.7 bits (86), Expect = 0.025
Identities = 43/202 (21%), Positives = 90/202 (44%), Gaps = 15/202 (7%)
Query: 316 QITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMER 375
+IT + +Q E + N V L +++ +K +T +EL N +++ME+
Sbjct: 2204 EITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENK---LFKDDMEK 2260
Query: 376 ----VKE------ESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEM 425
+KE + ++L Q++ E L+E L+++ ++ D K +E
Sbjct: 2261 LGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTD-NKVIEE 2319
Query: 426 QISMRQEMELAMKMLEKDV-CEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSE 484
+ + +++E ++ L D C K++ + Q + + L+ ELA Q + + SE
Sbjct: 2320 KNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSE 2379
Query: 485 LNSRLEEKTNQMAATIKQLEQR 506
L+ + + + A LEQ+
Sbjct: 2380 EADSLKHQLDVVIAEKLALEQQ 2401
Score = 36.2 bits (82), Expect = 0.072
Identities = 43/190 (22%), Positives = 90/190 (47%), Gaps = 18/190 (9%)
Query: 320 ILDQKNYVEELNRHLNATVNNLQAKVDA-LEKSNTKLT----EELAVANNRI-ITLQEEM 373
+ + K +E L + NA ++ + +A LE+ T+L EEL+ + I + +
Sbjct: 593 VTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINI 652
Query: 374 ERVKEESSYILESNRKGPKQDRTAEGQALSEARKHL-KEETQLRLDVEKELEMQISM--- 429
E++K+ + G + + + + + + + +L ++ QL L++ K ++Q S+
Sbjct: 653 EKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNS 712
Query: 430 -RQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSR 488
+EM L + L+K++ LRQ+ + L+ E+ ++L KQ E +
Sbjct: 713 KSEEMTLQINELQKEI-------EILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKEND 765
Query: 489 LEEKTNQMAA 498
L+EK Q+ A
Sbjct: 766 LQEKFAQLEA 775
Score = 34.7 bits (78), Expect = 0.21
Identities = 45/200 (22%), Positives = 84/200 (42%), Gaps = 24/200 (12%)
Query: 308 SKGTEGDGQITAILDQKNY----VEELNRHLNATVNN-LQAKVDALEKSNTKLTEELAVA 362
SK TE +++ L + + ++ N L +++ LQA V+ L ++ ++ + +L A
Sbjct: 1812 SKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHA 1871
Query: 363 NNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKE 422
L E R K+E++ L+ E R+ L EE++ R + E
Sbjct: 1872 KVTQTELMRESFRQKQEATESLKCQE---------------ELRERLHEESRAREQLAVE 1916
Query: 423 LEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQK 482
L + + E+ + EK D + L Q+L EL + Q ++++
Sbjct: 1917 LSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQ----IQEE 1972
Query: 483 SELNSRLEEKTNQMAATIKQ 502
EL SR +E A ++Q
Sbjct: 1973 RELLSRQKEAMKAEAGPVEQ 1992
Score = 32.7 bits (73), Expect = 0.80
Identities = 46/194 (23%), Positives = 82/194 (42%), Gaps = 38/194 (19%)
Query: 341 LQAKVDALEKSNTKLT----------EELAVANNRIITLQEEMERVKEESS---YILESN 387
LQA+ DA+++ ++T EEL N + L ++E K+ES+ LE
Sbjct: 2191 LQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQE 2250
Query: 388 RKGPKQD------RTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQ----EMELAM 437
K K D E A+S +H+ ++ EKE+E+ Q + +L +
Sbjct: 2251 NKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKI 2310
Query: 438 KMLEKDVCEKQDALVSLRQQLD----DLRALK----------HELAFKLQSSDLGVKQKS 483
K + EK + + L Q++ D +K +E+ KLQ + QK+
Sbjct: 2311 TTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKT 2370
Query: 484 ELNSR-LEEKTNQM 496
+N+ L E+ + +
Sbjct: 2371 SMNAHSLSEEADSL 2384
Score = 32.0 bits (71), Expect = 1.4
Identities = 64/286 (22%), Positives = 114/286 (39%), Gaps = 52/286 (18%)
Query: 227 LRLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKG 286
LR++ ++ ++ E +LI +KE + E E N L E++ + LL G K
Sbjct: 2606 LRISELESQVVEMHTSLILEKEQV-EIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKR 2664
Query: 287 EDLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVD 346
D V V+ + L N G N +E L AT +A++
Sbjct: 2665 SPQD--VEVLKTTTELFHSNEESGFF------------NELEALRAESVAT----KAELA 2706
Query: 347 ALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEAR 406
+ ++ KL EEL V + +LQ+++ +V++ L+EA+
Sbjct: 2707 SYKEKAEKLQEELLVKETNMTSLQKDLSQVRDH----------------------LAEAK 2744
Query: 407 KHLKEETQLRLDVEKELEMQISMRQEM-ELAMKMLEKDVCEKQDALVSLRQQLDDLRALK 465
+ L L+ E E E+Q S + M E L K + + D + + + L
Sbjct: 2745 EKLS-----ILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILV 2799
Query: 466 HELAFKLQ-SSDLGVKQKSELNSRLEEKTNQM----AATIKQLEQR 506
++ S+ ++ +E+ S+ EK +M AA I +E R
Sbjct: 2800 KNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESR 2845
Score = 31.6 bits (70), Expect = 1.8
Identities = 36/155 (23%), Positives = 68/155 (43%), Gaps = 25/155 (16%)
Query: 320 ILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEE 379
++++KN EL R L + L + + ++++ + E+L N I LQ+E+ + ++
Sbjct: 2316 VIEEKN---ELIRDLETQIECLMSDQECVKRNREEEIEQL---NEVIEKLQQELANIGQK 2369
Query: 380 SSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKM 439
+S +LSE LK + + + + LE Q+ E MK
Sbjct: 2370 TS---------------MNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKN 2414
Query: 440 LEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQS 474
+ K+ K + L Q+L L+ + E K+QS
Sbjct: 2415 VLKETNFKMN---QLTQELFSLKR-ERESVEKIQS 2445
Score = 31.6 bits (70), Expect = 1.8
Identities = 42/209 (20%), Positives = 84/209 (40%), Gaps = 29/209 (13%)
Query: 316 QITAILDQ-KNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEME 374
Q+ +L+Q K + E + + + A++ + N +L L RI + ++
Sbjct: 3258 QLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLD 3317
Query: 375 RVKEESSYILESNRKG------PKQDRTAEGQA------------LSEARKHLKEETQLR 416
R +E + + S+ G P +D E Q L+E K+ + Q R
Sbjct: 3318 RERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTR 3377
Query: 417 LDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAF------ 470
+EK+ ++ Q + A +K + E Q + L++QL++ R ++L
Sbjct: 3378 QQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQ 3437
Query: 471 ----KLQSSDLGVKQKSELNSRLEEKTNQ 495
+ Q +L ++K E L + N+
Sbjct: 3438 GIMQEFQKQELEREEKRESRRILYQNLNE 3466
Score = 30.8 bits (68), Expect = 3.0
Identities = 28/115 (24%), Positives = 54/115 (46%), Gaps = 9/115 (7%)
Query: 393 QDRTAEGQALSEA-----RKHLKEETQLRLDVEKELEMQISMRQEMEL-AMKMLEKDVCE 446
Q++ E QA E R+ L E Q ++ + QE E + ++LE ++ +
Sbjct: 3069 QEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQ 3128
Query: 447 KQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIK 501
KQ ++ ++ +L ++ EL +L S + V +EL S L + ++ T+K
Sbjct: 3129 KQSQMLEMQVELSSMKDRATELQEQLSSEKMVV---AELKSELAQTKLELETTLK 3180
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 52.8 bits (125), Expect = 7e-07
Identities = 42/167 (25%), Positives = 75/167 (44%), Gaps = 25/167 (14%)
Query: 311 TEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQ 370
++ +G I D+K E +Q K D +++ L +EL A+NR+ L+
Sbjct: 1918 SKAEGVIDGYADEKTLFER----------QIQEKTDIIDR----LEQELLCASNRLQELE 1963
Query: 371 EEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMR 430
E ++++EE + + E Q L E K +KE+ +++ EK +R
Sbjct: 1964 AEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEK-------VR 2016
Query: 431 QEMELAMKMLEKDVCEKQDALVSLRQ----QLDDLRALKHELAFKLQ 473
+++ +K LE DV E+ + L Q +L DLR L +L+
Sbjct: 2017 DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLE 2063
Score = 45.4 bits (106), Expect = 1e-04
Identities = 52/253 (20%), Positives = 115/253 (45%), Gaps = 35/253 (13%)
Query: 284 MKGEDLDSQVGVIDFSMYLKDGNSSKGTEG--------------DG---QITAILDQ--- 323
M+ E Q + + + L++ + GTEG DG Q+TA L Q
Sbjct: 160 MESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARR 219
Query: 324 ------KNYVE--ELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMER 375
+ ++E E ++ L LQA +++ +L A +I+T Q+++
Sbjct: 220 EKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQL-- 277
Query: 376 VKEESSYILESNRKGPKQDRTAEGQALSEARK--HLKEETQLRLDVEKELEMQISMRQEM 433
EE ++LE +K K+D T + L E K ++++ ++ ++E++ + ++ +E+
Sbjct: 278 --EEQDHLLEDYQK-KKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEEL 334
Query: 434 ELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKT 493
+ EK E +D L + + L +L+ + ++++ L + + + E+
Sbjct: 335 NTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEI 394
Query: 494 NQMAATIKQLEQR 506
Q+ T+++L++R
Sbjct: 395 KQLMGTVEELQKR 407
Score = 42.7 bits (99), Expect = 8e-04
Identities = 50/213 (23%), Positives = 91/213 (42%), Gaps = 37/213 (17%)
Query: 328 EELNRHLNATVNNLQAKVDALEKSNTKLTEELAVA-------NNRIITLQEEMERVKEES 380
++ +R L + +AK+ E+ + + E+L + N ++ L E+ +++ ES
Sbjct: 3206 QKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNES 3265
Query: 381 SYILESNRK------GPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQ--- 431
+ES R +Q R E Q L E+ K E LD E+EL Q+
Sbjct: 3266 QQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTG 3325
Query: 432 ------EMELAMKMLEKDVCEKQDALVSL--------------RQQLD-DLRALKHELAF 470
E +K L+K + EK +V L RQQ++ D + + L
Sbjct: 3326 QSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQT 3385
Query: 471 KLQSSDLGVKQKSELNSRLEEKTNQMAATIKQL 503
+ +++ G K+ EL S++E+ Q+ +Q+
Sbjct: 3386 EQEANTEGQKKMHELQSKVEDLQRQLEEKRQQV 3418
Score = 37.7 bits (86), Expect = 0.025
Identities = 43/202 (21%), Positives = 90/202 (44%), Gaps = 15/202 (7%)
Query: 316 QITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMER 375
+IT + +Q E + N V L +++ +K +T +EL N +++ME+
Sbjct: 2196 EITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENK---LFKDDMEK 2252
Query: 376 ----VKE------ESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEM 425
+KE + ++L Q++ E L+E L+++ ++ D K +E
Sbjct: 2253 LGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTD-NKVIEE 2311
Query: 426 QISMRQEMELAMKMLEKDV-CEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSE 484
+ + +++E ++ L D C K++ + Q + + L+ ELA Q + + SE
Sbjct: 2312 KNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSE 2371
Query: 485 LNSRLEEKTNQMAATIKQLEQR 506
L+ + + + A LEQ+
Sbjct: 2372 EADSLKHQLDVVIAEKLALEQQ 2393
Score = 36.2 bits (82), Expect = 0.072
Identities = 43/190 (22%), Positives = 90/190 (47%), Gaps = 18/190 (9%)
Query: 320 ILDQKNYVEELNRHLNATVNNLQAKVDA-LEKSNTKLT----EELAVANNRI-ITLQEEM 373
+ + K +E L + NA ++ + +A LE+ T+L EEL+ + I + +
Sbjct: 593 VTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINI 652
Query: 374 ERVKEESSYILESNRKGPKQDRTAEGQALSEARKHL-KEETQLRLDVEKELEMQISM--- 429
E++K+ + G + + + + + + + +L ++ QL L++ K ++Q S+
Sbjct: 653 EKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNS 712
Query: 430 -RQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSR 488
+EM L + L+K++ LRQ+ + L+ E+ ++L KQ E +
Sbjct: 713 KSEEMTLQINELQKEI-------EILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKEND 765
Query: 489 LEEKTNQMAA 498
L+EK Q+ A
Sbjct: 766 LQEKFAQLEA 775
Score = 34.7 bits (78), Expect = 0.21
Identities = 45/200 (22%), Positives = 84/200 (42%), Gaps = 24/200 (12%)
Query: 308 SKGTEGDGQITAILDQKNY----VEELNRHLNATVNN-LQAKVDALEKSNTKLTEELAVA 362
SK TE +++ L + + ++ N L +++ LQA V+ L ++ ++ + +L A
Sbjct: 1812 SKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHA 1871
Query: 363 NNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKE 422
L E R K+E++ L+ E R+ L EE++ R + E
Sbjct: 1872 KVTQTELMRESFRQKQEATESLKCQE---------------ELRERLHEESRAREQLAVE 1916
Query: 423 LEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQK 482
L + + E+ + EK D + L Q+L EL + Q ++++
Sbjct: 1917 LSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQ----IQEE 1972
Query: 483 SELNSRLEEKTNQMAATIKQ 502
EL SR +E A ++Q
Sbjct: 1973 RELLSRQKEAMKAEAGPVEQ 1992
Score = 33.1 bits (74), Expect = 0.61
Identities = 52/220 (23%), Positives = 93/220 (42%), Gaps = 40/220 (18%)
Query: 316 QITAILDQKNY-VEELNRHLNATVNNLQAKVDALEKSNTKLT----------EELAVANN 364
Q + D+K++ E L+ V LQA+ DA+++ ++T EEL N
Sbjct: 2158 QALLVEDRKHFGAVEAKPELSLEVQ-LQAERDAIDRKEKEITNLEEQLEQFREELENKNE 2216
Query: 365 RIITLQEEMERVKEESS---YILESNRKGPKQD------RTAEGQALSEARKHLKEETQL 415
+ L ++E K+ES+ LE K K D E A+S +H+
Sbjct: 2217 EVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFA 2276
Query: 416 RLDVEKELEMQISMRQ----EMELAMKMLEKDVCEKQDALVSLRQQLD----DLRALK-- 465
++ EKE+E+ Q + +L + K + EK + + L Q++ D +K
Sbjct: 2277 QIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRN 2336
Query: 466 --------HELAFKLQSSDLGVKQKSELNSR-LEEKTNQM 496
+E+ KLQ + QK+ +N+ L E+ + +
Sbjct: 2337 REEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSL 2376
Score = 32.0 bits (71), Expect = 1.4
Identities = 64/286 (22%), Positives = 114/286 (39%), Gaps = 52/286 (18%)
Query: 227 LRLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKG 286
LR++ ++ ++ E +LI +KE + E E N L E++ + LL G K
Sbjct: 2598 LRISELESQVVEMHTSLILEKEQV-EIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKR 2656
Query: 287 EDLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVD 346
D V V+ + L N G N +E L AT +A++
Sbjct: 2657 SPQD--VEVLKTTTELFHSNEESGFF------------NELEALRAESVAT----KAELA 2698
Query: 347 ALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEAR 406
+ ++ KL EEL V + +LQ+++ +V++ L+EA+
Sbjct: 2699 SYKEKAEKLQEELLVKETNMTSLQKDLSQVRDH----------------------LAEAK 2736
Query: 407 KHLKEETQLRLDVEKELEMQISMRQEM-ELAMKMLEKDVCEKQDALVSLRQQLDDLRALK 465
+ L L+ E E E+Q S + M E L K + + D + + + L
Sbjct: 2737 EKLS-----ILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILV 2791
Query: 466 HELAFKLQ-SSDLGVKQKSELNSRLEEKTNQM----AATIKQLEQR 506
++ S+ ++ +E+ S+ EK +M AA I +E R
Sbjct: 2792 KNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESR 2837
Score = 31.6 bits (70), Expect = 1.8
Identities = 42/209 (20%), Positives = 84/209 (40%), Gaps = 29/209 (13%)
Query: 316 QITAILDQ-KNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEME 374
Q+ +L+Q K + E + + + A++ + N +L L RI + ++
Sbjct: 3250 QLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLD 3309
Query: 375 RVKEESSYILESNRKG------PKQDRTAEGQA------------LSEARKHLKEETQLR 416
R +E + + S+ G P +D E Q L+E K+ + Q R
Sbjct: 3310 RERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTR 3369
Query: 417 LDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAF------ 470
+EK+ ++ Q + A +K + E Q + L++QL++ R ++L
Sbjct: 3370 QQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQ 3429
Query: 471 ----KLQSSDLGVKQKSELNSRLEEKTNQ 495
+ Q +L ++K E L + N+
Sbjct: 3430 GIMQEFQKQELEREEKRESRRILYQNLNE 3458
Score = 30.8 bits (68), Expect = 3.0
Identities = 28/115 (24%), Positives = 54/115 (46%), Gaps = 9/115 (7%)
Query: 393 QDRTAEGQALSEA-----RKHLKEETQLRLDVEKELEMQISMRQEMEL-AMKMLEKDVCE 446
Q++ E QA E R+ L E Q ++ + QE E + ++LE ++ +
Sbjct: 3061 QEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQ 3120
Query: 447 KQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIK 501
KQ ++ ++ +L ++ EL +L S + V +EL S L + ++ T+K
Sbjct: 3121 KQSQMLEMQVELSSMKDRATELQEQLSSEKMVV---AELKSELAQTKLELETTLK 3172
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 52.4 bits (124), Expect = 1e-06
Identities = 47/209 (22%), Positives = 98/209 (46%), Gaps = 25/209 (11%)
Query: 314 DGQITAILDQKNYVEELNRHLNATVNNLQAK-------VDALEKSNTKLTEELAVANNRI 366
+ +I + ++ EE+N L A L+ + +D LE + K+ +E N++
Sbjct: 919 EAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV 978
Query: 367 ITLQEEMERVKE------ESSYILESNRKGPKQDRTAEG---QALSEARKHLKEETQLRL 417
L EEM + E + L+ + D AE L++A+ L+++
Sbjct: 979 KNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVD--- 1035
Query: 418 DVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSL---RQQLDDLRALKHELAFKLQS 474
D+E LE + +R ++E A + LE D+ Q++ + + +QQLD+ K F++ +
Sbjct: 1036 DLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKE---FEISN 1092
Query: 475 SDLGVKQKSELNSRLEEKTNQMAATIKQL 503
++ + + +L++K ++ A I++L
Sbjct: 1093 LISKIEDEQAVEIQLQKKIKELQARIEEL 1121
Score = 39.3 bits (90), Expect = 0.009
Identities = 46/234 (19%), Positives = 92/234 (39%), Gaps = 24/234 (10%)
Query: 287 EDLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVD 346
EDL Q+ +++ L ++ A L+Q E + + + +V
Sbjct: 1668 EDLKEQLAIVERRANLLQAEIE-------ELWATLEQ---TERSRKIAEQELLDASERVQ 1717
Query: 347 ALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKG------------PKQD 394
L NT L N + LQ E+E V +ES E +K +QD
Sbjct: 1718 LLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQD 1777
Query: 395 RTAEGQALSEARKHLKEETQLRLDVEKELEMQISMR--QEMELAMKMLEKDVCEKQDALV 452
+A + + + + ++ Q RLD ++L ++ + Q++E ++ LE +V +Q
Sbjct: 1778 TSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNA 1837
Query: 453 SLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQR 506
+ L EL ++ + V + +L +L+ K ++ E++
Sbjct: 1838 EAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQ 1891
Score = 38.1 bits (87), Expect = 0.019
Identities = 59/285 (20%), Positives = 111/285 (38%), Gaps = 49/285 (17%)
Query: 246 KKELLSEFYEPNALMMEEEGAIIAGLLVGLNVI----DANFCMKGEDLD----------- 290
K E+ + E A + EEG I+ + + LN + D K E++D
Sbjct: 1540 KCEIQAALEEAEASLEHEEGKILR-IQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVE 1598
Query: 291 SQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELN-------RHLNATVNNLQA 343
+ +D + ++ + +G + + Q N+ L R+ + Q
Sbjct: 1599 TMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQL 1658
Query: 344 KVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQAL- 402
+D + L E+LA+ R LQ E+ EE LE + K AE + L
Sbjct: 1659 HLDDALRGQEDLKEQLAIVERRANLLQAEI----EELWATLEQTERSRK---IAEQELLD 1711
Query: 403 -SEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDL 461
SE + L + ++ +K+LE +S Q +E+ + E ++A ++ + D
Sbjct: 1712 ASERVQLLHTQNTSLINTKKKLENDVSQLQ------SEVEEVIQESRNAEEKAKKAITDA 1765
Query: 462 RALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQR 506
+ EL K++ + ++ LE + T+K L+ R
Sbjct: 1766 AMMAEEL-----------KKEQDTSAHLERMKKNLEQTVKDLQHR 1799
Score = 37.4 bits (85), Expect = 0.032
Identities = 76/320 (23%), Positives = 132/320 (41%), Gaps = 58/320 (18%)
Query: 227 LRLALMQKKLSEYMKALINKKELLSEFYEPNALM-MEEEGAIIAGLLVGLNVIDANFCMK 285
L+LA E K +++K EF N + +E+E A+ L + + A
Sbjct: 1062 LKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEEL 1121
Query: 286 GEDLDSQVGV--------IDFSMYLKDGNSSKGTEGDGQITAI--LDQKNYVE--ELNRH 333
GE+++++ D S L++ S + E G +A L++K E +L R
Sbjct: 1122 GEEIEAERASRAKAEKQRSDLSRELEE-ISERLEEAGGATSAQVELNKKREAEFQKLRRD 1180
Query: 334 LNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQ 393
L +A V AL K K + +A +I LQ +++++E S + K
Sbjct: 1181 LEEATLQHEAMVAALRK---KHADSMAELGEQIDNLQRVKQKLEKEKSEL-----KMETD 1232
Query: 394 DRTAEGQALSEARKHL----------------KEETQLRLDVEKELEMQISMRQEMELAM 437
D ++ +A+S+A+ +L KEE Q RL + + + E +
Sbjct: 1233 DLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSR 1292
Query: 438 KMLEKDVCEKQ---------DALVSLRQQLDDLRALKHELAFKLQSS----DLGVKQ--- 481
++ EKD Q + L+ QL++ K+ LA LQSS DL +Q
Sbjct: 1293 QLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEE 1352
Query: 482 ----KSELNSRLEEKTNQMA 497
K+EL L + +++A
Sbjct: 1353 EQEGKAELQRALSKANSEVA 1372
Score = 33.9 bits (76), Expect = 0.36
Identities = 40/200 (20%), Positives = 81/200 (40%), Gaps = 23/200 (11%)
Query: 312 EGDGQITAILDQKNYVEELNRHLNATVNNLQAKVD-------ALEKSNTKLTEELAVANN 364
E + + A+ + +E+ + L V +L V+ AL+K + L+
Sbjct: 1402 EAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQ 1461
Query: 365 RIITLQEEMERVKEESSYILES--NRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKE 422
+ Q E+E ++ES + K ++ + + L K+L++E D+ ++
Sbjct: 1462 KYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEIS---DLTEQ 1518
Query: 423 LEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLD-----------DLRALKHELAFK 471
+ E+E K +E++ CE Q AL L+ +L +K E+ K
Sbjct: 1519 IAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRK 1578
Query: 472 LQSSDLGVKQKSELNSRLEE 491
+ D + Q ++R+ E
Sbjct: 1579 IAEKDEEIDQLKRNHTRVVE 1598
Score = 32.0 bits (71), Expect = 1.4
Identities = 29/160 (18%), Positives = 71/160 (44%), Gaps = 15/160 (9%)
Query: 360 AVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDV 419
A + T++EE ++ K+E + E+ RK ++ + ++ + ++ E D
Sbjct: 846 AETEKEMATMKEEFQKTKDELAKS-EAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADA 904
Query: 420 EKELEMQISMRQEMELAMKMLEKDVCEKQ--------------DALVSLRQQLDDLRALK 465
E+ E I + ++E +K + + E++ D L++ +DDL
Sbjct: 905 EERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTL 964
Query: 466 HELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQ 505
++ + +++ VK +E + L+E +++ K L++
Sbjct: 965 AKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQE 1004
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.131 0.369
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,701,806
Number of Sequences: 37866
Number of extensions: 1298177
Number of successful extensions: 11603
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 234
Number of HSP's successfully gapped in prelim test: 1132
Number of HSP's that attempted gapping in prelim test: 7833
Number of HSP's gapped (non-prelim): 3922
length of query: 506
length of database: 18,247,518
effective HSP length: 107
effective length of query: 399
effective length of database: 14,195,856
effective search space: 5664146544
effective search space used: 5664146544
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.