Search of human proteins with 193083117

Search of human proteins with 193083117

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|193083117 cytochrome P450 family 24 subfamily A polypeptide
1 isoform 2 precursor [Homo sapiens]
         (448 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|193083117 cytochrome P450 family 24 subfamily A polypeptide 1...   905   0.0  
gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1 ...   836   0.0  
gi|4503211 cytochrome P450, family 27, subfamily A, polypeptide ...   204   1e-52
gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide ...   181   1e-45
gi|153218646 cytochrome P450, family 11, subfamily A, polypeptid...   177   2e-44
gi|71067343 cytochrome P450, family 11, subfamily B, polypeptide...   163   3e-40
gi|61743918 cytochrome P450, family 11, subfamily B, polypeptide...   151   1e-36
gi|119829183 cytochrome P450, family 11, subfamily B, polypeptid...   149   4e-36
gi|167466231 cytochrome P450, family 27, subfamily C, polypeptid...   145   9e-35
gi|153218654 cytochrome P450, family 11, subfamily A, polypeptid...   119   7e-27
gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide ...    98   1e-20
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5...    94   3e-19
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ...    90   4e-18
gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11...    86   9e-17
gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11...    86   9e-17
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7...    84   2e-16
gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6...    84   3e-16
gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide...    82   8e-16
gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8...    82   8e-16
gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide ...    82   1e-15
gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide...    80   3e-15
gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide ...    80   4e-15
gi|62952506 cytochrome P450, family 4, subfamily A, polypeptide ...    79   8e-15
gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide...    78   1e-14
gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide ...    78   2e-14
gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide...    78   2e-14
gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide ...    77   2e-14
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ...    77   2e-14
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ...    77   2e-14
gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ...    77   3e-14

>gi|193083117 cytochrome P450 family 24 subfamily A polypeptide 1
           isoform 2 precursor [Homo sapiens]
          Length = 448

 Score =  905 bits (2339), Expect = 0.0
 Identities = 448/448 (100%), Positives = 448/448 (100%)

Query: 1   MSSPISKSRSLAAFLQQLRSPRQPPRLVTSTAYTSPQPREVPVCPLTAGGETQNAAALPG 60
           MSSPISKSRSLAAFLQQLRSPRQPPRLVTSTAYTSPQPREVPVCPLTAGGETQNAAALPG
Sbjct: 1   MSSPISKSRSLAAFLQQLRSPRQPPRLVTSTAYTSPQPREVPVCPLTAGGETQNAAALPG 60

Query: 61  PTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYR 120
           PTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYR
Sbjct: 61  PTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYR 120

Query: 121 TESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKIN 180
           TESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKIN
Sbjct: 121 TESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKIN 180

Query: 181 EVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIM 240
           EVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIM
Sbjct: 181 EVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIM 240

Query: 241 AIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPSAD 300
           AIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPSAD
Sbjct: 241 AIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPSAD 300

Query: 301 FLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVL 360
           FLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVL
Sbjct: 301 FLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVL 360

Query: 361 PENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGIVRKYDIQ 420
           PENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGIVRKYDIQ
Sbjct: 361 PENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGIVRKYDIQ 420

Query: 421 ATDNEPVEMLHSGTLVPSRELPIAFCQR 448
           ATDNEPVEMLHSGTLVPSRELPIAFCQR
Sbjct: 421 ATDNEPVEMLHSGTLVPSRELPIAFCQR 448


>gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1
           isoform 1 precursor [Homo sapiens]
          Length = 514

 Score =  836 bits (2160), Expect = 0.0
 Identities = 418/441 (94%), Positives = 420/441 (95%)

Query: 1   MSSPISKSRSLAAFLQQLRSPRQPPRLVTSTAYTSPQPREVPVCPLTAGGETQNAAALPG 60
           MSSPISKSRSLAAFLQQLRSPRQPPRLVTSTAYTSPQPREVPVCPLTAGGETQNAAALPG
Sbjct: 1   MSSPISKSRSLAAFLQQLRSPRQPPRLVTSTAYTSPQPREVPVCPLTAGGETQNAAALPG 60

Query: 61  PTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYR 120
           PTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYR
Sbjct: 61  PTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYR 120

Query: 121 TESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKIN 180
           TESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKIN
Sbjct: 121 TESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKIN 180

Query: 181 EVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIM 240
           EVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIM
Sbjct: 181 EVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIM 240

Query: 241 AIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPSAD 300
           AIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPSAD
Sbjct: 241 AIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPSAD 300

Query: 301 FLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVL 360
           FLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVL
Sbjct: 301 FLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVL 360

Query: 361 PENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGIVRKYDIQ 420
           PENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKG V   + Q
Sbjct: 361 PENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQ 420

Query: 421 ATDNEPVEMLHSGTLVPSREL 441
              +       S    P R L
Sbjct: 421 VLGSSEDNFEDSSQFRPERWL 441



 Score = 76.6 bits (187), Expect = 4e-14
 Identities = 36/36 (100%), Positives = 36/36 (100%)

Query: 413 IVRKYDIQATDNEPVEMLHSGTLVPSRELPIAFCQR 448
           IVRKYDIQATDNEPVEMLHSGTLVPSRELPIAFCQR
Sbjct: 479 IVRKYDIQATDNEPVEMLHSGTLVPSRELPIAFCQR 514


>gi|4503211 cytochrome P450, family 27, subfamily A, polypeptide 1
           precursor [Homo sapiens]
          Length = 531

 Score =  204 bits (520), Expect = 1e-52
 Identities = 129/397 (32%), Positives = 198/397 (49%), Gaps = 27/397 (6%)

Query: 65  PLLGSL---LQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYRT 121
           P LG L    Q+  +G   + H   V Y  KYG ++   LG    V+L S  LLE + R 
Sbjct: 61  PRLGQLRFFFQLFVQGYALQLHQLQVLYKAKYGPMWMSYLGPQMHVNLASAPLLEQVMRQ 120

Query: 122 ESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKINE 181
           E  YP R +++ WK +RD     YG    EG  W ++R A  ++L+KP E     +  NE
Sbjct: 121 EGKYPVRNDMELWKEHRDQHDLTYGPFTTEGHHWYQLRQALNQRLLKPAEAALYTDAFNE 180

Query: 182 VLADFMGRIDELCDERG---HVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNF 238
           V+ DFM R+D+L  E      V D+      ++ E+IC +L+EKR G LQ++  ++ V F
Sbjct: 181 VIDDFMTRLDQLRAESASGNQVSDMAQLFYYFALEAICYILFEKRIGCLQRSIPEDTVTF 240

Query: 239 IMAIKTMM-----STFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKY 293
           + +I  M      +TF      PV          W+ +   W+ IF   K  ID +LE  
Sbjct: 241 VRSIGLMFQNSLYATFLPKWTRPV-------LPFWKRYLDGWNAIFSFGKKLIDEKLEDM 293

Query: 294 SQQPSA---------DFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSR 344
             Q  A          +L  +    +LS +E   ++ EL +A V+TT+N+L W LY+LS+
Sbjct: 294 EAQLQAAGPDGIQVSGYLHFLLASGQLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSK 353

Query: 345 NPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVL 404
           +P++Q+ L +E+  V+P  QVP+ +D  +MP LKA LKE++RL P VP  +R ++K   +
Sbjct: 354 DPEIQEALHEEVVGVVPAGQVPQHKDFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEV 413

Query: 405 GEYALPKGIVRKYDIQATDNEPVEMLHSGTLVPSREL 441
             +  PK     +       +P       +  P R L
Sbjct: 414 DGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWL 450


>gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 508

 Score =  181 bits (459), Expect = 1e-45
 Identities = 126/407 (30%), Positives = 194/407 (47%), Gaps = 25/407 (6%)

Query: 53  QNAAALPGPTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSP 112
           ++ A +PGP++   L  L     KGGL + H+  V+    +G ++    G+  +V++ +P
Sbjct: 35  RSLADIPGPSTPSFLAELF---CKGGLSRLHELQVQGAAHFGPVWLASFGTVRTVYVAAP 91

Query: 113 CLLEALYRTESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEV 172
            L+E L R E   P+R    PW  +R  R+   GLL  EGE+WQR+RS     L++P   
Sbjct: 92  ALVEELLRQEGPRPERCSFSPWTEHRRCRQRACGLLTAEGEEWQRLRSLLAPLLLRPQAA 151

Query: 173 MKLDNKINEVLADFMGRIDELCDERGH-------VEDLYSELNKWSFESICLVLYEKRFG 225
            +    +N V+ D + R+     +RG        V D+  E  K+  E I  VL   R G
Sbjct: 152 ARYAGTLNNVVCDLVRRLRR---QRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRLG 208

Query: 226 LLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKAC 285
            L+     +   FI A+ ++  +    M  P  L + L    W      WD +F   +  
Sbjct: 209 CLEAQVPPDTETFIRAVGSVFVSTLLTMAMPHWL-RHLVPGPWGRLCRDWDQMFAFAQRH 267

Query: 286 IDNRLEKYSQ----QPSADFLCDIYHQNRLSKKELYAA-----VTELQLAAVETTANSLM 336
           ++ R  + +     QP  D     +  + L ++EL A      VTEL LA V+T +N+L 
Sbjct: 268 VERREAEAAMRNGGQPEKDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVSNTLS 327

Query: 337 WILYNLSRNPQVQQKLLKEIQSVLP--ENQVPRAEDLRNMPYLKACLKESMRLTPSVPFT 394
           W LY LSR+P+VQ  L  EI + L    +  P A  L  +P LKA +KE +RL P VP  
Sbjct: 328 WALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVPGN 387

Query: 395 TRTLDKATVLGEYALPKGIVRKYDIQATDNEPVEMLHSGTLVPSREL 441
           +R  DK   +G+Y +PK  +      AT  +P +     +  P+R L
Sbjct: 388 SRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWL 434


>gi|153218646 cytochrome P450, family 11, subfamily A, polypeptide 1
           isoform a precursor [Homo sapiens]
          Length = 521

 Score =  177 bits (449), Expect = 2e-44
 Identities = 121/396 (30%), Positives = 194/396 (48%), Gaps = 11/396 (2%)

Query: 54  NAAALPGPTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPC 113
           N    PG   W    +L     + G  K H   V+  +KYG I+R KLG+ ESV++  P 
Sbjct: 49  NEIPSPGDNGWL---NLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPE 105

Query: 114 LLEALYRTESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVM 173
            +  L+++E   P+R  I PW AY  Y +   G+L+ +   W++ R A  +++M P    
Sbjct: 106 DVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATK 165

Query: 174 KLDNKINEVLADFMGRIDELCDERG---HVEDLYSELNKWSFESICLVLYEKRFGLLQKN 230
                ++ V  DF+  +     + G   +  D+  +L +++FESI  V++ +R G+L++ 
Sbjct: 166 NFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEV 225

Query: 231 AGDEAVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRL 290
              EA  FI AI  M  T   M+  P +L +   TK W+DH  AWD IF        N  
Sbjct: 226 VNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFY 285

Query: 291 EKYSQQPSA--DFLCDIYH---QNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRN 345
            +  Q+ S   D+   +Y     +++S +++ A VTE+    V+TT+ +L W LY ++RN
Sbjct: 286 WELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARN 345

Query: 346 PQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLG 405
            +VQ  L  E+ +   + Q   A  L+ +P LKA +KE++RL P      R L    VL 
Sbjct: 346 LKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLR 405

Query: 406 EYALPKGIVRKYDIQATDNEPVEMLHSGTLVPSREL 441
           +Y +P   + +  I A   EP          P+R L
Sbjct: 406 DYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWL 441


>gi|71067343 cytochrome P450, family 11, subfamily B, polypeptide 1
           isoform 2 precursor [Homo sapiens]
          Length = 437

 Score =  163 bits (413), Expect = 3e-40
 Identities = 105/375 (28%), Positives = 185/375 (49%), Gaps = 6/375 (1%)

Query: 70  LLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYRTESAYPQRL 129
           LLQI  + G +  H  + +  ++ G IFR  LG    V +  P  +E L + +S +P R+
Sbjct: 52  LLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRM 111

Query: 130 EIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKINEVLADFMGR 189
            ++PW AYR +R    G+ +L G +W+  R     +++ P  V +    ++ V  DF   
Sbjct: 112 SLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQA 171

Query: 190 IDE--LCDERGHVE-DLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMM 246
           + +  L + RG +  D+   +  ++ E+  L L+ +R GL+  +    ++NF+ A++ M 
Sbjct: 172 LKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMF 231

Query: 247 STFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYS---QQPSADFLC 303
            +  ++M  P  L +  + KVW++H  AWD IF+    CI    ++ +    Q     + 
Sbjct: 232 KSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVA 291

Query: 304 DIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPEN 363
           ++     LS   + A   EL   +V+TT   L+  L+ L+RNP VQQ L +E  +     
Sbjct: 292 ELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASI 351

Query: 364 QVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGIVRKYDIQATD 423
                +    +P L+A LKE++RL P   F  R      VL  Y +P G+++   ++   
Sbjct: 352 SEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGVLKHLQVETLT 411

Query: 424 NEPVEMLHSGTLVPS 438
            E ++M++S  L PS
Sbjct: 412 QEDIKMVYSFILRPS 426


>gi|61743918 cytochrome P450, family 11, subfamily B, polypeptide 1
           isoform 1 precursor [Homo sapiens]
          Length = 503

 Score =  151 bits (382), Expect = 1e-36
 Identities = 104/380 (27%), Positives = 179/380 (47%), Gaps = 6/380 (1%)

Query: 70  LLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYRTESAYPQRL 129
           LLQI  + G +  H  + +  ++ G IFR  LG    V +  P  +E L + +S +P R+
Sbjct: 52  LLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRM 111

Query: 130 EIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKINEVLADFMGR 189
            ++PW AYR +R    G+ +L G +W+  R     +++ P  V +    ++ V  DF   
Sbjct: 112 SLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQA 171

Query: 190 IDE--LCDERGHVE-DLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMM 246
           + +  L + RG +  D+   +  ++ E+  L L+ +R GL+  +    ++NF+ A++ M 
Sbjct: 172 LKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMF 231

Query: 247 STFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYS---QQPSADFLC 303
            +  ++M  P  L +  + KVW++H  AWD IF+    CI    ++ +    Q     + 
Sbjct: 232 KSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVA 291

Query: 304 DIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPEN 363
           ++     LS   + A   EL   +V+TT   L+  L+ L+RNP VQQ L +E  +     
Sbjct: 292 ELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASI 351

Query: 364 QVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGIVRKYDIQATD 423
                +    +P L+A LKE++RL P   F  R      VL  Y +P G + +  + +  
Sbjct: 352 SEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLG 411

Query: 424 NEPVEMLHSGTLVPSRELPI 443
             P          P R L I
Sbjct: 412 RNPALFPRPERYNPQRWLDI 431


>gi|119829183 cytochrome P450, family 11, subfamily B, polypeptide 2
           precursor [Homo sapiens]
          Length = 503

 Score =  149 bits (377), Expect = 4e-36
 Identities = 100/349 (28%), Positives = 174/349 (49%), Gaps = 6/349 (1%)

Query: 70  LLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYRTESAYPQRL 129
           LLQI  + G +  H  + +  ++ G IFR  LG    V +  P  +E L + +S +P R+
Sbjct: 52  LLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRM 111

Query: 130 EIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKINEVLADFMGR 189
            ++PW AYR +R    G+ +L G +W+  R      ++ P  V +    ++ V  DF   
Sbjct: 112 ILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQA 171

Query: 190 IDE--LCDERGHVE-DLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMM 246
           + +  L + RG +  D+   +  ++ E+  L L+ +R GL+  +    ++NF+ A++ M 
Sbjct: 172 LKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMF 231

Query: 247 STFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYS---QQPSADFLC 303
            +  ++M  P  L + ++ KVW++H  AWD IF+    CI    ++ +    Q     + 
Sbjct: 232 KSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVA 291

Query: 304 DIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPEN 363
           ++  +  LS + + A   EL   +V+TTA  L+  L+ L+RNP VQQ L +E  +     
Sbjct: 292 ELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASI 351

Query: 364 QVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKG 412
                +    +P L+A LKE++RL P   F  R +    VL  Y +P G
Sbjct: 352 SEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAG 400


>gi|167466231 cytochrome P450, family 27, subfamily C, polypeptide 1
           [Homo sapiens]
          Length = 372

 Score =  145 bits (365), Expect = 9e-35
 Identities = 89/269 (33%), Positives = 143/269 (53%), Gaps = 17/269 (6%)

Query: 158 VRSAFQKKLMKPGEVMKLDNKINEVLADFMGRIDELCDERGHVEDLYSELN------KWS 211
           +RS  +++++KP +V     ++N+V+AD + RI  L   R   ED  +  N      K+S
Sbjct: 1   MRSVLRQRILKPKDVAIYSGEVNQVIADLIKRIYLL---RSQAEDGETVTNVNDLFFKYS 57

Query: 212 FESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPV--ELHKSLNTKVWQ 269
            E +  +LYE R G L+ +     V +I A++ M S F   M         +    K W+
Sbjct: 58  MEGVATILYESRLGCLENSIPQLTVEYIEALELMFSMFKTSMYAGAIPRWLRPFIPKPWR 117

Query: 270 DHTLAWDTIFKSVKACIDNRLEKYSQQP------SADFLCDIYHQNRLSKKELYAAVTEL 323
           +   +WD +FK  +  +DN+L     Q       S   L  ++    L+ +E+YA VTE+
Sbjct: 118 EFCRSWDGLFKFSQIHVDNKLRDIQYQMDRGRRVSGGLLTYLFLSQALTLQEIYANVTEM 177

Query: 324 QLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKE 383
            LA V+TT+ +L W +Y L+R+P+VQQ + +EI   L E  VP A D+  +P ++A LKE
Sbjct: 178 LLAGVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVPTAADVPKVPLVRALLKE 237

Query: 384 SMRLTPSVPFTTRTLDKATVLGEYALPKG 412
           ++RL P +P   R   +  V+G Y +PKG
Sbjct: 238 TLRLFPVLPGNGRVTQEDLVIGGYLIPKG 266


>gi|153218654 cytochrome P450, family 11, subfamily A, polypeptide 1
           isoform b [Homo sapiens]
          Length = 363

 Score =  119 bits (297), Expect = 7e-27
 Identities = 79/245 (32%), Positives = 124/245 (50%), Gaps = 5/245 (2%)

Query: 202 DLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPVELHK 261
           D+  +L +++FESI  V++ +R G+L++    EA  FI AI  M  T   M+  P +L +
Sbjct: 39  DISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFR 98

Query: 262 SLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPSA--DFLCDIYH---QNRLSKKEL 316
              TK W+DH  AWD IF        N   +  Q+ S   D+   +Y     +++S +++
Sbjct: 99  LFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDI 158

Query: 317 YAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPY 376
            A VTE+    V+TT+ +L W LY ++RN +VQ  L  E+ +   + Q   A  L+ +P 
Sbjct: 159 KANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPL 218

Query: 377 LKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGIVRKYDIQATDNEPVEMLHSGTLV 436
           LKA +KE++RL P      R L    VL +Y +P   + +  I A   EP          
Sbjct: 219 LKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFD 278

Query: 437 PSREL 441
           P+R L
Sbjct: 279 PTRWL 283


>gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide 2
           [Homo sapiens]
          Length = 502

 Score = 98.2 bits (243), Expect = 1e-20
 Identities = 98/403 (24%), Positives = 167/403 (41%), Gaps = 40/403 (9%)

Query: 59  PGPTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHL-GSPCLLEA 117
           PGP   P LG+   +      ++ H  +  + KKYG +F ++LG   +V + G P + EA
Sbjct: 45  PGPWRLPFLGNFFLV----DFEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEA 100

Query: 118 LYRTESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMK-LD 176
           L   +  +  R    P    R++  +  GL++  G+ W+  R      L   G   K L+
Sbjct: 101 LIHMDQNFGNR----PVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLE 156

Query: 177 NKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGD--- 233
            +I E        I E   E G   D + ++N      IC + + +RF            
Sbjct: 157 ERIQEEAQHLTEAIKE---ENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQLLK 213

Query: 234 --EAVNFIMAIKT--MMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNR 289
             + V ++ A KT  + + F  +M      H++L +         W  +   V   ID  
Sbjct: 214 LLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSN--------WKKLKLFVSHMIDKH 265

Query: 290 LEKYSQQPSADFLCDIYHQ----------NRLSKKELYAAVTELQLAAVETTANSLMWIL 339
            + ++   + DF+ D Y +          +   ++ L  +  +L  A  ETT+ +L W L
Sbjct: 266 RKDWNPAETRDFI-DAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWAL 324

Query: 340 YNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTT-RTL 398
             ++  P++Q+K+  EI  V+ + Q P      +MPY  A + E  R+   +P    R +
Sbjct: 325 LYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREV 384

Query: 399 DKATVLGEYALPKGIVRKYDIQATDNEPVEMLHSGTLVPSREL 441
              T L  Y LPKG +   ++ A   +P E     T  P   L
Sbjct: 385 TVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFL 427


>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
           [Homo sapiens]
          Length = 502

 Score = 93.6 bits (231), Expect = 3e-19
 Identities = 105/396 (26%), Positives = 173/396 (43%), Gaps = 55/396 (13%)

Query: 58  LPGPTSWPLLGSLL---QILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCL 114
           +PGPT  PLLG++L   Q LWK       DT  E +KKYGK++    G    + +  P +
Sbjct: 38  IPGPTPLPLLGNVLSYRQGLWK------FDT--ECYKKYGKMWGTYEGQLPVLAITDPDV 89

Query: 115 LEALYRTE--SAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLM--KPG 170
           +  +   E  S +  R  + P    +        + + E E+W+R+RS         K  
Sbjct: 90  IRTVLVKECYSVFTNRRSLGPVGFMKS------AISLAEDEEWKRIRSLLSPTFTSGKLK 143

Query: 171 EVMKLDNKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKN 230
           E+  +  +  +VL   + R  E    +G    L      +S +    V+    FG+   +
Sbjct: 144 EMFPIIAQYGDVLVRNLRREAE----KGKPVTLKDIFGAYSMD----VITGTSFGVNIDS 195

Query: 231 AGDEAVNFIMAIKTMMSTFGRM-----------MVTPVELHKSLNTKVWQDHTLAWDTIF 279
             +    F+ + K  +  FG +            +TPV   ++LN  ++   T+ +  + 
Sbjct: 196 LNNPQDPFVESTKKFLK-FGFLDPLFLSIILFPFLTPV--FEALNVSLFPKDTINF--LS 250

Query: 280 KSVKACIDNRLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAA---------VET 330
           KSV     +RL    Q+   DFL  +       + E + A+++L+LAA          ET
Sbjct: 251 KSVNRMKKSRLND-KQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYET 309

Query: 331 TANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPS 390
           T++ L + LY L+ +P VQQKL KEI +VLP    P  + +  M YL   + E++RL P 
Sbjct: 310 TSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPV 369

Query: 391 VPFTTRTLDKATVLGEYALPKGIVRKYDIQATDNEP 426
                RT  K   +    +PKG +      A  ++P
Sbjct: 370 AIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDP 405


>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
           [Homo sapiens]
          Length = 503

 Score = 90.1 bits (222), Expect = 4e-18
 Identities = 102/403 (25%), Positives = 171/403 (42%), Gaps = 43/403 (10%)

Query: 58  LPGPTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEA 117
           +PGPT  P LG++L    KG         +E HKKYGK++    G    + +  P +++ 
Sbjct: 38  IPGPTPLPFLGNILSY-HKGFCMFD----MECHKKYGKVWGFYDGQQPVLAITDPDMIKT 92

Query: 118 LYRTE--SAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLM--KPGEVM 173
           +   E  S +  R    P    +        + I E E+W+R+RS         K  E++
Sbjct: 93  VLVKECYSVFTNRRPFGPVGFMKS------AISIAEDEEWKRLRSLLSPTFTSGKLKEMV 146

Query: 174 KLDNKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGD 233
            +  +  +VL   + R  E     G    L      +S +    V+    FG+   +  +
Sbjct: 147 PIIAQYGDVLVRNLRREAET----GKPVTLKDVFGAYSMD----VITSTSFGVNIDSLNN 198

Query: 234 EAVNFIMAIKTMMST------FGRMMVTP--VELHKSLNTKVWQDHTLAWDTIFKSVKAC 285
               F+   K ++        F  + V P  + + + LN  V+      +  + KSVK  
Sbjct: 199 PQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNF--LRKSVKRM 256

Query: 286 IDNRLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAA---------VETTANSLM 336
            ++RLE  +Q+   DFL  +       + E + A+++L+L A          ETT++ L 
Sbjct: 257 KESRLED-TQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLS 315

Query: 337 WILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTR 396
           +I+Y L+ +P VQQKL +EI +VLP    P  + +  M YL   + E++RL P      R
Sbjct: 316 FIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLER 375

Query: 397 TLDKATVLGEYALPKGIVRKYDIQATDNEPVEMLHSGTLVPSR 439
              K   +    +PKG+V      A   +P         +P R
Sbjct: 376 VCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPER 418


>gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11
           [Homo sapiens]
          Length = 524

 Score = 85.5 bits (210), Expect = 9e-17
 Identities = 91/365 (24%), Positives = 163/365 (44%), Gaps = 56/365 (15%)

Query: 85  TLVEYHKKYGKIFRMKLG-SFESVHLGSPCLLEALYRTESAYPQRLEI-----KPWKAYR 138
           TL +    Y + F++ LG +F  + L  P ++  +    +A   +  I     KPW    
Sbjct: 76  TLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPKDMIFYGFLKPWL--- 132

Query: 139 DYRKEGYGLLILEGEDWQRVRS----AFQKKLMKPGEVMKLDNKINEVLADFMGRIDELC 194
                G GLL+  G+ W R R     AF   ++KP   MK+ NK   ++ D   R   L 
Sbjct: 133 -----GDGLLLSGGDKWSRHRRMLTPAFHFNILKP--YMKIFNKSVNIMHDKWQR---LA 182

Query: 195 DERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMMV 254
            E     D++  ++  + +S+   ++       + N  ++   +I AI  + S F     
Sbjct: 183 SEGSARLDMFEHISLMTLDSLQKCVFS-----FESNCQEKPSEYIAAILEL-SAFVEKRN 236

Query: 255 TPVELHKSLNTKVWQD-----------HTLAWDTIFKSVKAC-----IDNRLEKYSQQPS 298
             + LH      +  D           H    D + +  +       ID+ L+  ++  +
Sbjct: 237 QQILLHTDFLYYLTPDGQRFRRACHLVHDFT-DAVIQERRCTLPTQGIDDFLKNKAKSKT 295

Query: 299 ADFLCDIYHQNR------LSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKL 352
            DF+ D+   ++      LS +++ A          +TTA+ L W+LY+L+++P+ Q++ 
Sbjct: 296 LDFI-DVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQC 354

Query: 353 LKEIQSVLPENQVPRAE--DLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGE-YAL 409
            +E+Q +L + +    E  DL  +P+L  C+KES+RL P VP  +R   +  VL +   +
Sbjct: 355 RQEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVI 414

Query: 410 PKGIV 414
           PKGIV
Sbjct: 415 PKGIV 419


>gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11
           [Homo sapiens]
          Length = 524

 Score = 85.5 bits (210), Expect = 9e-17
 Identities = 91/365 (24%), Positives = 163/365 (44%), Gaps = 56/365 (15%)

Query: 85  TLVEYHKKYGKIFRMKLG-SFESVHLGSPCLLEALYRTESAYPQRLEI-----KPWKAYR 138
           TL +    Y + F++ LG +F  + L  P ++  +    +A   +  I     KPW    
Sbjct: 76  TLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPKDMIFYGFLKPWL--- 132

Query: 139 DYRKEGYGLLILEGEDWQRVRS----AFQKKLMKPGEVMKLDNKINEVLADFMGRIDELC 194
                G GLL+  G+ W R R     AF   ++KP   MK+ NK   ++ D   R   L 
Sbjct: 133 -----GDGLLLSGGDKWSRHRRMLTPAFHFNILKP--YMKIFNKSVNIMHDKWQR---LA 182

Query: 195 DERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMMV 254
            E     D++  ++  + +S+   ++       + N  ++   +I AI  + S F     
Sbjct: 183 SEGSARLDMFEHISLMTLDSLQKCVFS-----FESNCQEKPSEYIAAILEL-SAFVEKRN 236

Query: 255 TPVELHKSLNTKVWQD-----------HTLAWDTIFKSVKAC-----IDNRLEKYSQQPS 298
             + LH      +  D           H    D + +  +       ID+ L+  ++  +
Sbjct: 237 QQILLHTDFLYYLTPDGQRFRRACHLVHDFT-DAVIQERRCTLPTQGIDDFLKNKAKSKT 295

Query: 299 ADFLCDIYHQNR------LSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKL 352
            DF+ D+   ++      LS +++ A          +TTA+ L W+LY+L+++P+ Q++ 
Sbjct: 296 LDFI-DVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQC 354

Query: 353 LKEIQSVLPENQVPRAE--DLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGE-YAL 409
            +E+Q +L + +    E  DL  +P+L  C+KES+RL P VP  +R   +  VL +   +
Sbjct: 355 RQEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVI 414

Query: 410 PKGIV 414
           PKGIV
Sbjct: 415 PKGIV 419


>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
           [Homo sapiens]
          Length = 503

 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 101/411 (24%), Positives = 173/411 (42%), Gaps = 59/411 (14%)

Query: 58  LPGPTSWPLLGSLLQILWKGGLKKQHDTL-VEYHKKYGKIFRMKLGSFESVHLGSPCLLE 116
           +PGPT  P LG+ L        +K + T  +E +KKY K++ +       + +  P +++
Sbjct: 38  IPGPTPLPFLGNALSF------RKGYWTFDMECYKKYRKVWGIYDCQQPMLAITDPDMIK 91

Query: 117 ALYRTE--SAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLM--KPGEV 172
            +   E  S +  R    P    ++       + I E E+W+R+RS         K  E+
Sbjct: 92  TVLVKECYSVFTNRRPFGPVGFMKN------AISIAEDEEWKRIRSLLSPTFTSGKLKEM 145

Query: 173 MKLDNKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLY------------ 220
           + +  +  +VL   + R  E     G    L      +S + I    +            
Sbjct: 146 VPIIAQYGDVLVRNLRREAET----GKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQD 201

Query: 221 ---EKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDT 277
              E    LL+ N  D    F+++IK          +TP+   ++LN  V+    +++ T
Sbjct: 202 PFVENTKKLLRFNPLDP---FVLSIKVFP------FLTPIL--EALNITVFPRKVISFLT 250

Query: 278 IFKSVKACIDNRLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQL---------AAV 328
             KSVK   + RL K +Q+   DFL  +         E + A+++L+L         A  
Sbjct: 251 --KSVKQIKEGRL-KETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGY 307

Query: 329 ETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLT 388
           ETT++ L +I+Y L+ +P VQQK+ KEI +VLP    P  + +  + YL   + E++RL 
Sbjct: 308 ETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLF 367

Query: 389 PSVPFTTRTLDKATVLGEYALPKGIVRKYDIQATDNEPVEMLHSGTLVPSR 439
           P      R   K   +    +PKG+V         ++P         +P R
Sbjct: 368 PVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPER 418


>gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6
           [Homo sapiens]
          Length = 491

 Score = 84.0 bits (206), Expect = 3e-16
 Identities = 94/370 (25%), Positives = 157/370 (42%), Gaps = 34/370 (9%)

Query: 59  PGPTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHL-GSPCLLEA 117
           PGP   PLLG+LLQ+  +G LK    + + + +KYG +F + LG    V L G   + EA
Sbjct: 32  PGPRPLPLLGNLLQMDRRGLLK----SFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREA 87

Query: 118 LYRTESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMK--L 175
           L     A+  R +I    A  D    GYG++   G  W+ +R  F    M+   + K  +
Sbjct: 88  LVDKAEAFSGRGKI----AMVDPFFRGYGVIFANGNRWKVLRR-FSVTTMRDFGMGKRSV 142

Query: 176 DNKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEA 235
           + +I E   +    I+EL   +G + D        +   IC +++ KRF    +      
Sbjct: 143 EERIQE---EAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKML 199

Query: 236 VNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQ 295
             F      + S FG++     EL           H   +  + + + A I + +EK+ +
Sbjct: 200 NLFYQTFSLISSVFGQLF----ELFSGFLKYFPGAHRQVYKNL-QEINAYIGHSVEKHRE 254

Query: 296 --QPSADF-LCDIY----------HQNRLSKKELYAAVTELQLAAVETTANSLMWILYNL 342
              PSA   L D Y            +  S + L      L  A  ETT+ +L +    +
Sbjct: 255 TLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLM 314

Query: 343 SRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPF-TTRTLDKA 401
            + P V +++ +EI+ V+  ++ P   D   MPY +A + E  R +  +P      + + 
Sbjct: 315 LKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQH 374

Query: 402 TVLGEYALPK 411
           T    Y +PK
Sbjct: 375 TSFRGYIIPK 384


>gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide 3
           [Homo sapiens]
          Length = 520

 Score = 82.4 bits (202), Expect = 8e-16
 Identities = 78/320 (24%), Positives = 138/320 (43%), Gaps = 40/320 (12%)

Query: 131 IKPWKAYRDYRKEGYGLLILEGEDWQRVR----SAFQKKLMKPGEVMKLDNKINEVLADF 186
           +KPW         G GLL+  GE W R R     AF   ++KP   MK+    NE +   
Sbjct: 128 LKPWL--------GDGLLLSAGEKWSRHRRMLTPAFHFNILKP--YMKI---FNESVNIM 174

Query: 187 MGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMM 246
             +   L  E     D++  ++  + +S+   ++   F    +    E +  I+ +  ++
Sbjct: 175 HAKWQLLASEGSARLDMFEHISLMTLDSLQKCVFS--FDSHCQEKPSEYIAAILELSALV 232

Query: 247 STFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPSADFL---- 302
           +   + ++  ++    L T   Q    A   +     A I  R      Q   DFL    
Sbjct: 233 TKRHQQILLYIDFLYYL-TPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKA 291

Query: 303 -------CDIY------HQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQ 349
                   D+          +LS +++ A          +TTA+ L W+LY+L+++P+ Q
Sbjct: 292 KSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQ 351

Query: 350 QKLLKEIQSVLPENQVPRAE--DLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGE- 406
           ++  +E+Q +L + +    E  DL  +P+L  C+KES+RL P VP  +R   +  VL + 
Sbjct: 352 ERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDG 411

Query: 407 YALPKGIVRKYDIQATDNEP 426
             +PKGI+    +  T + P
Sbjct: 412 RVIPKGIICLISVFGTHHNP 431


>gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8
           [Homo sapiens]
          Length = 520

 Score = 82.4 bits (202), Expect = 8e-16
 Identities = 82/351 (23%), Positives = 156/351 (44%), Gaps = 49/351 (13%)

Query: 107 VHLGSPCLLEALYRTESAYPQR-----LEIKPWKAYRDYRKEGYGLLILEGEDWQRVRS- 160
           ++L  P ++ ++  T  A   +       +KPW         G GLL+  G+ W+  R  
Sbjct: 99  INLCHPDIVRSVINTSDAITDKDIVFYKTLKPWL--------GDGLLLSVGDKWRHHRRL 150

Query: 161 ---AFQKKLMKPGEVMKLDNKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICL 217
              AF   ++KP   +K+ +K   ++     +   L  E     D++  ++  + +S+  
Sbjct: 151 LTPAFHFNILKP--YIKIFSKSANIMH---AKWQRLAMEGSTCLDVFEHISLMTLDSLQK 205

Query: 218 VLYEKRFGLLQKNAGDEAVNFIMAIKTMM----STFGRM-----MVTPVELHKSLNTKVW 268
            ++       +K +  E +  IM +  ++    + F R       +TP         ++ 
Sbjct: 206 CIFSFDSNCQEKPS--EYITAIMELSALVVKRNNQFFRYKDFLYFLTPCGRRFHRACRLV 263

Query: 269 QDHTLAWDTIFKSVKAC-----IDNRLEKYSQQPSADF-----LCDIYHQNRLSKKELYA 318
            D T   D + +  +       +D+ L+  ++  + DF     L +  +   LS +++ A
Sbjct: 264 HDFT---DAVIQERRRTLTSQGVDDFLQAKAKSKTLDFIDVLLLSEDKNGKELSDEDIRA 320

Query: 319 AVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAE--DLRNMPY 376
                     +TTA+ L W+LYNL+R+P+ Q++  +E+Q +L + +    E  DL  +P+
Sbjct: 321 EADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPF 380

Query: 377 LKACLKESMRLTPSVPFTTRTLDKATVLGE-YALPKGIVRKYDIQATDNEP 426
           L  CLKES+RL P +P   R   +  VL +   +PKG V   +I A  + P
Sbjct: 381 LTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHHNP 431


>gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide 2
           [Homo sapiens]
          Length = 520

 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 75/307 (24%), Positives = 135/307 (43%), Gaps = 32/307 (10%)

Query: 144 GYGLLILEGEDWQRVR----SAFQKKLMKPGEVMKLDNKINEVLADFMGRIDELCDERGH 199
           G GLL+  G+ W R R     AF   ++KP   MK+    NE +     +   L  E   
Sbjct: 133 GDGLLLSAGDKWSRHRRMLTPAFHFNILKP--YMKI---FNESVNIMHAKWQLLASEGSA 187

Query: 200 VEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPVEL 259
             D++  ++  + +S+   ++   F    +    E +  I+ +  ++S     ++  ++ 
Sbjct: 188 CLDMFEHISLMTLDSLQKCVFS--FDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDF 245

Query: 260 HKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPSADFL-----------CDIY-- 306
              L T   Q    A   +     A I  R      Q   DFL            D+   
Sbjct: 246 LYYL-TPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLL 304

Query: 307 ----HQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPE 362
                  +LS +++ A          +TTA+ L W+LY+L+++P+ Q++  +E+Q +L +
Sbjct: 305 SKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKD 364

Query: 363 NQVPRAE--DLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGE-YALPKGIVRKYDI 419
            +    E  DL ++P+L  C+KES+RL P VP  +R + +  VL +   +PKGI+    +
Sbjct: 365 REPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISV 424

Query: 420 QATDNEP 426
             T + P
Sbjct: 425 FGTHHNP 431


>gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide 12
           [Homo sapiens]
          Length = 524

 Score = 80.5 bits (197), Expect = 3e-15
 Identities = 73/320 (22%), Positives = 142/320 (44%), Gaps = 40/320 (12%)

Query: 131 IKPWKAYRDYRKEGYGLLILEGEDWQRVRS----AFQKKLMKPGEVMKLDNKINEVLADF 186
           +KPW         G G+L+  G+ W R R     AF   ++K    + + NK   ++ D 
Sbjct: 128 LKPWL--------GEGILLSGGDKWSRHRRMLTPAFHFNILK--SYITIFNKSANIMLD- 176

Query: 187 MGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMM 246
             +   L  E     D++  ++  + +S+   ++   F    +    E +  I+ +  ++
Sbjct: 177 --KWQHLASEGSSRLDMFEHISLMTLDSLQKCIFS--FDSHCQERPSEYIATILELSALV 232

Query: 247 STFGRMMVTPVELHKSLNTKVWQDHTLA------WDTIFKSVKAC-----IDNRLEKYSQ 295
               + ++  ++    L+    + H          D + +  +       ID+  +  ++
Sbjct: 233 EKRSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAK 292

Query: 296 QPSADFLCDIYHQNR------LSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQ 349
             + DF+ D+   ++      LS +++ A          +TTA+ L W+LYNL+R+P+ Q
Sbjct: 293 SKTLDFI-DVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQ 351

Query: 350 QKLLKEIQSVLPENQVPRAE--DLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGE- 406
           ++  +E+Q +L +      E  DL  +P+L  C+KES+RL P  PF +R   +  VL + 
Sbjct: 352 ERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDG 411

Query: 407 YALPKGIVRKYDIQATDNEP 426
             +PKGI    DI    + P
Sbjct: 412 RVIPKGITCLIDIIGVHHNP 431


>gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide 1
           [Homo sapiens]
          Length = 490

 Score = 80.1 bits (196), Expect = 4e-15
 Identities = 93/375 (24%), Positives = 155/375 (41%), Gaps = 46/375 (12%)

Query: 59  PGPTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEAL 118
           PGP   PL+G+L  +     L +Q  +L+E  ++YG +F + LG  ++V L      EA+
Sbjct: 33  PGPRPLPLVGNLHLLR----LSQQDRSLMELSERYGPVFTVHLGRQKTVVLTG---FEAV 85

Query: 119 YRTESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMK-LDN 177
               +   Q L  +P  A     + G G+    G  W+  R    + L   G   + + +
Sbjct: 86  KEALAGPGQELADRPPIAIFQLIQRGGGIFFSSGARWRAARQFTVRALHSLGVGREPVAD 145

Query: 178 KINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICL-VLYEKRF-----------G 225
           KI + L    G++D     RG    L   L  W+  +I   +L+ +RF           G
Sbjct: 146 KILQELKCLSGQLDGY---RGRPFPL--ALLGWAPSNITFALLFGRRFDYRDPVFVSLLG 200

Query: 226 LLQK------NAGDEAVNFIMAIKTMMSTFGRMMVTPVELHKSLNT--KVWQDHTLAWDT 277
           L+ +      + G +  N    +  ++     ++    E+   L T  +  + H    D 
Sbjct: 201 LIDEVMVLLGSPGLQLFNVYPWLGALLQLHRPVLRKIEEVRAILRTLLEARRPHVCPGDP 260

Query: 278 IFKSVKACIDNRLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMW 337
           +   V A I        QQ   D       +   ++    A   ++ +A  ETT+ +L W
Sbjct: 261 VCSYVDALI--------QQGQGDD-----PEGLFAEANAVACTLDMVMAGTETTSATLQW 307

Query: 338 ILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRT 397
               + R+P VQ ++ +E+  VL   + PR ED + +PY  A L E  R    +P   R 
Sbjct: 308 AALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQRFITLLPHVPRC 367

Query: 398 LDKATVLGEYALPKG 412
               T LG + LPKG
Sbjct: 368 TAADTQLGGFLLPKG 382


>gi|62952506 cytochrome P450, family 4, subfamily A, polypeptide 22
           [Homo sapiens]
          Length = 519

 Score = 79.0 bits (193), Expect = 8e-15
 Identities = 82/323 (25%), Positives = 144/323 (44%), Gaps = 36/323 (11%)

Query: 144 GYGLLILEGEDWQRVRS----AFQKKLMKPGEVMKLDNKINEVLADFMGRIDELCDERGH 199
           GYGLL+L G+ W + R     AF   ++KP   +  D+    V+ D   + +EL  +   
Sbjct: 128 GYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSV--RVMLD---KWEELLGQDSP 182

Query: 200 VEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPVEL 259
           +E ++  ++  + ++I    +  + G +Q +   ++  +I AI  + S     M      
Sbjct: 183 LE-VFQHVSLMTLDTIMKSAFSHQ-GSIQVDRNSQS--YIQAISDLNSLVFCCMRNAFHE 238

Query: 260 HKSLNT------------KVWQDHTLAWDTIFKSVKACI--DNRLEKYSQQPSADFL--- 302
           + ++ +            ++   HT   D + +  KA +  +  LEK  ++   DFL   
Sbjct: 239 NDTIYSLTSAGRWTHRACQLAHQHT---DQVIQLRKAQLQKEGELEKIKRKRHLDFLDIL 295

Query: 303 --CDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVL 360
               + + + LS K+L A V        +TTA+ + WILY L+ +P+ Q++  +EI  +L
Sbjct: 296 LLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLL 355

Query: 361 PENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGE-YALPKGIVRKYDI 419
            +        L  MPY   C+KE++RL P VP   R L       +  +LPKGI+    I
Sbjct: 356 GDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSI 415

Query: 420 QATDNEPVEMLHSGTLVPSRELP 442
               + P    +     PSR  P
Sbjct: 416 YGLHHNPKVWPNLEVFDPSRFAP 438


>gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide 6
           [Homo sapiens]
          Length = 494

 Score = 78.2 bits (191), Expect = 1e-14
 Identities = 92/383 (24%), Positives = 169/383 (44%), Gaps = 58/383 (15%)

Query: 59  PGPTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHL-GSPCLLEA 117
           PGPT  P +G+ LQ+      ++ +++L++  ++YG +F + LG    V L G   + EA
Sbjct: 35  PGPTPLPFIGNYLQL----NTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREA 90

Query: 118 LYRTESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMK--L 175
           L      +  R E    +A  D+  +GYG++   GE  +++R  F    ++   V K  +
Sbjct: 91  LVDQAEEFSGRGE----QATFDWVFKGYGVVFSNGERAKQLR-RFSIATLRDFGVGKRGI 145

Query: 176 DNKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEA 235
           + +I E  A F+  ID L    G   D    L++     I  +++  RF    K      
Sbjct: 146 EERIQEE-AGFL--IDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDK------ 196

Query: 236 VNFIMAIKTMMSTFGRMMVTPVELHKSLNT----------KVWQDHTLAWDTIFKSV--- 282
             F+  ++ M+  F     +  +L++  ++          + +Q      D I K V   
Sbjct: 197 -EFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHN 255

Query: 283 ---------KACIDN---RLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVET 330
                    +  ID+   R+++  + P+ +F            K L      L +   ET
Sbjct: 256 QRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYL----------KNLVMTTLNLFIGGTET 305

Query: 331 TANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPS 390
            + +L +    L ++P+V+ K+ +EI  V+ +N+ P+ ED   MPY++A + E  R    
Sbjct: 306 VSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDV 365

Query: 391 VPFT-TRTLDKATVLGEYALPKG 412
           +P +  R + K T   ++ LPKG
Sbjct: 366 IPMSLARRVKKDTKFRDFFLPKG 388


>gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide 13
           [Homo sapiens]
          Length = 494

 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 93/374 (24%), Positives = 167/374 (44%), Gaps = 40/374 (10%)

Query: 59  PGPTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHL-GSPCLLEA 117
           PGPT  P +G+ LQ+      ++ +++L++  ++YG +F + LG    V L G   + EA
Sbjct: 35  PGPTPLPFIGNYLQL----NTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVKEA 90

Query: 118 LYRTESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMK--L 175
           L      +  R E    +A  D+  +GYG+    GE  +++R  F    ++   V K  +
Sbjct: 91  LVDQAEEFSGRGE----QATFDWLFKGYGVAFSNGERAKQLR-RFSIATLRGFGVGKRGI 145

Query: 176 DNKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEA 235
           + +I E  A F+  ID L    G   D    L++     I  +++  RF    K      
Sbjct: 146 EERIQEE-AGFL--IDALRGTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDK------ 196

Query: 236 VNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACID-------- 287
             F+  ++ M+ +F     +  +L++  ++ V +         FK ++   D        
Sbjct: 197 -EFLSLLRMMLGSFQFTATSTGQLYEMFSS-VMKHLPGPQQQAFKELQGLEDFIAKKVEH 254

Query: 288 --NRLEKYSQQPSAD-FLCDIYHQNRLSKKELY---AAVTELQL--AAVETTANSLMWIL 339
               L+  S +   D FL  +  + +    E Y     +T L L  A  ET + +L +  
Sbjct: 255 NQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGF 314

Query: 340 YNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPF-TTRTL 398
             L ++P+V+ K+ +EI  V+ +N+ P+ ED   MPY +A + E  R    +P      +
Sbjct: 315 LLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRV 374

Query: 399 DKATVLGEYALPKG 412
           +K T   ++ LPKG
Sbjct: 375 NKDTKFRDFFLPKG 388


>gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide 11
           [Homo sapiens]
          Length = 519

 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 80/307 (26%), Positives = 140/307 (45%), Gaps = 36/307 (11%)

Query: 144 GYGLLILEGEDWQRVRS----AFQKKLMKPGEVMKLDNKINEVLADFMGRIDELCDERGH 199
           GYGLL+L G+ W + R     AF   ++KP   +  D+    V+ D   + +EL  +   
Sbjct: 128 GYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSV--RVMLD---KWEELLGQDSP 182

Query: 200 VEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMMS-TFGRMM----- 253
           +E ++  ++  + ++I    +  + G +Q +   ++  +I AI  + +  F R+      
Sbjct: 183 LE-VFQHVSLMTLDTIMKCAFSHQ-GSIQVDRNSQS--YIQAISDLNNLVFSRVRNAFHQ 238

Query: 254 ------VTPVELHKSLNTKVWQDHTLAWDTIFKSVKACI--DNRLEKYSQQPSADFL--- 302
                 +T          ++   HT   D + +  KA +  +  LEK  ++   DFL   
Sbjct: 239 NDTIYSLTSAGRWTHRACQLAHQHT---DQVIQLRKAQLQKEGELEKIKRKRHLDFLDIL 295

Query: 303 --CDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVL 360
               + + + LS K+L A V        +TTA+ + WILY L+ +P+ Q++  +EI S+L
Sbjct: 296 LLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLL 355

Query: 361 PENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGE-YALPKGIVRKYDI 419
            +        L  MPY   C+KE++RL P VP   R L       +  +LPKGI+    I
Sbjct: 356 GDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSI 415

Query: 420 QATDNEP 426
               + P
Sbjct: 416 YGLHHNP 422


>gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 3 [Homo sapiens]
          Length = 420

 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 92/407 (22%), Positives = 179/407 (43%), Gaps = 51/407 (12%)

Query: 58  LPGPTSWPLLGSLL---QILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCL 114
           +PGPT  P LG++L   + LW            E ++KYG+++ +  G    + +  P +
Sbjct: 38  IPGPTPLPFLGTILFYLRGLWNFDR--------ECNEKYGEMWGLYEGQQPMLVIMDPDM 89

Query: 115 LEALYRTE--SAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKL--MKPG 170
           ++ +   E  S +  ++ + P    +        L   E E+W+R+R+        +K  
Sbjct: 90  IKTVLVKECYSVFTNQMPLGPMGFLKS------ALSFAEDEEWKRIRTLLSPAFTSVKFK 143

Query: 171 EVMKLDNKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKN 230
           E++ + ++  ++L   + R +    +  +++D +     ++ + I   L+      L  N
Sbjct: 144 EMVPIISQCGDMLVRSL-RQEAENSKSINLKDFFGA---YTMDVITGTLFGVNLDSLN-N 198

Query: 231 AGDE---------AVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKS 281
             D           ++F+     ++S F    +TPV   ++LN  ++      +  +  S
Sbjct: 199 PQDPFLKNMKKLLKLDFLDPFLLLISLFP--FLTPV--FEALNIGLFPKDVTHF--LKNS 252

Query: 282 VKACIDNRLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQL---------AAVETTA 332
           ++   ++RL K  Q+   DF   +       + + + A+++L+L         AA +TT+
Sbjct: 253 IERMKESRL-KDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTS 311

Query: 333 NSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVP 392
            +L +I+Y L+ +P VQQKL +EI +VLP       + L  M YL   + E++RL P V 
Sbjct: 312 TTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVS 371

Query: 393 FTTRTLDKATVLGEYALPKGIVRKYDIQATDNEPVEMLHSGTLVPSR 439
             TR   K   +    +PKG+     I A  ++P          P R
Sbjct: 372 RVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPER 418


>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 2 [Homo sapiens]
          Length = 503

 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 92/407 (22%), Positives = 179/407 (43%), Gaps = 51/407 (12%)

Query: 58  LPGPTSWPLLGSLL---QILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCL 114
           +PGPT  P LG++L   + LW            E ++KYG+++ +  G    + +  P +
Sbjct: 38  IPGPTPLPFLGTILFYLRGLWNFDR--------ECNEKYGEMWGLYEGQQPMLVIMDPDM 89

Query: 115 LEALYRTE--SAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKL--MKPG 170
           ++ +   E  S +  ++ + P    +        L   E E+W+R+R+        +K  
Sbjct: 90  IKTVLVKECYSVFTNQMPLGPMGFLKS------ALSFAEDEEWKRIRTLLSPAFTSVKFK 143

Query: 171 EVMKLDNKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKN 230
           E++ + ++  ++L   + R +    +  +++D +     ++ + I   L+      L  N
Sbjct: 144 EMVPIISQCGDMLVRSL-RQEAENSKSINLKDFFGA---YTMDVITGTLFGVNLDSLN-N 198

Query: 231 AGDE---------AVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKS 281
             D           ++F+     ++S F    +TPV   ++LN  ++      +  +  S
Sbjct: 199 PQDPFLKNMKKLLKLDFLDPFLLLISLFP--FLTPV--FEALNIGLFPKDVTHF--LKNS 252

Query: 282 VKACIDNRLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQL---------AAVETTA 332
           ++   ++RL K  Q+   DF   +       + + + A+++L+L         AA +TT+
Sbjct: 253 IERMKESRL-KDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTS 311

Query: 333 NSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVP 392
            +L +I+Y L+ +P VQQKL +EI +VLP       + L  M YL   + E++RL P V 
Sbjct: 312 TTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVS 371

Query: 393 FTTRTLDKATVLGEYALPKGIVRKYDIQATDNEPVEMLHSGTLVPSR 439
             TR   K   +    +PKG+     I A  ++P          P R
Sbjct: 372 RVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPER 418


>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
           [Homo sapiens]
          Length = 544

 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 100/435 (22%), Positives = 162/435 (37%), Gaps = 79/435 (18%)

Query: 59  PGPTSWPLLGSLLQILWKGGLKKQ-------------------HDTLVEYHKKYGKIFRM 99
           PGPT WPL+G+   +L    L+++                      L    + YG IF  
Sbjct: 61  PGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAGIDPSVIGPQVLLAHLARVYGSIFSF 120

Query: 100 KLGSFESVHLGS-PCLLEALYRTESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRV 158
            +G +  V L     + EAL +    +  R  +          KE   +    G  W++ 
Sbjct: 121 FIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVP---LISIVTKEKGVVFAHYGPVWRQQ 177

Query: 159 RSAFQKKLMKPG-EVMKLDNKINEVLADFMGRIDELCDERGHVEDLY---SELNKWSFES 214
           R      L   G   + L+ KI E        + +      H ED +   S ++      
Sbjct: 178 RKFSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQK------HGEDPFCPFSIISNAVSNI 231

Query: 215 ICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLA 274
           IC + + +RF                  K M+    R       L   LN++V   +   
Sbjct: 232 ICSLCFGQRFDYTNSE-----------FKKMLGFMSR------GLEICLNSQVLLVNICP 274

Query: 275 W----------------DTIFKSVKACIDNRLEKYSQQPSADFLCDIY-----------H 307
           W                  I   +K  I +  E   ++   DF+ D+Y            
Sbjct: 275 WLYYLPFGPFKELRQIEKDITSFLKKIIKDHQESLDRENPQDFI-DMYLLHMEEERKNNS 333

Query: 308 QNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPR 367
            +   ++ L+  + +L +A  +TT NSL+W L  +S NP VQ+K+ +EI+ V+  N+ P 
Sbjct: 334 NSSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPS 393

Query: 368 AEDLRNMPYLKACLKESMRLTPSVPFT-TRTLDKATVLGEYALPKGIVRKYDIQATDNEP 426
             D   MPY +A + E  RLT  VP        + TVL  Y +PKG +   ++ +   +P
Sbjct: 394 LTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDP 453

Query: 427 VEMLHSGTLVPSREL 441
                     P+R L
Sbjct: 454 AIWEKPEDFYPNRFL 468


>gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 1 [Homo sapiens]
          Length = 504

 Score = 77.0 bits (188), Expect = 3e-14
 Identities = 90/394 (22%), Positives = 177/394 (44%), Gaps = 51/394 (12%)

Query: 58  LPGPTSWPLLGSLL---QILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCL 114
           +PGPT  P LG++L   + LW            E ++KYG+++ +  G    + +  P +
Sbjct: 38  IPGPTPLPFLGTILFYLRGLWNFDR--------ECNEKYGEMWGLYEGQQPMLVIMDPDM 89

Query: 115 LEALYRTE--SAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKL--MKPG 170
           ++ +   E  S +  ++ + P    +        L   E E+W+R+R+        +K  
Sbjct: 90  IKTVLVKECYSVFTNQMPLGPMGFLKS------ALSFAEDEEWKRIRTLLSPAFTSVKFK 143

Query: 171 EVMKLDNKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKN 230
           E++ + ++  ++L   + R +    +  +++D +     ++ + I   L+      L  N
Sbjct: 144 EMVPIISQCGDMLVRSL-RQEAENSKSINLKDFFGA---YTMDVITGTLFGVNLDSLN-N 198

Query: 231 AGDE---------AVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKS 281
             D           ++F+     ++S F    +TPV   ++LN  ++      +  +  S
Sbjct: 199 PQDPFLKNMKKLLKLDFLDPFLLLISLFP--FLTPV--FEALNIGLFPKDVTHF--LKNS 252

Query: 282 VKACIDNRLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQL---------AAVETTA 332
           ++   ++RL K  Q+   DF   +       + + + A+++L+L         AA +TT+
Sbjct: 253 IERMKESRL-KDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTS 311

Query: 333 NSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVP 392
            +L +I+Y L+ +P VQQKL +EI +VLP       + L  M YL   + E++RL P V 
Sbjct: 312 TTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVS 371

Query: 393 FTTRTLDKATVLGEYALPKGIVRKYDIQATDNEP 426
             TR   K   +    +PKG+     I A  ++P
Sbjct: 372 RVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDP 405


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.134    0.399 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,203,306
Number of Sequences: 37866
Number of extensions: 772832
Number of successful extensions: 2604
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 68
Number of HSP's successfully gapped in prelim test: 22
Number of HSP's that attempted gapping in prelim test: 2419
Number of HSP's gapped (non-prelim): 142
length of query: 448
length of database: 18,247,518
effective HSP length: 106
effective length of query: 342
effective length of database: 14,233,722
effective search space: 4867932924
effective search space used: 4867932924
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.