Search of human proteins with 191252814

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|191252814 RIMS binding protein 3B [Homo sapiens]
         (1639 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|191252814 RIMS binding protein 3B [Homo sapiens]                  3322   0.0  
gi|191252806 RIMS binding protein 3C [Homo sapiens]                  3319   0.0  
gi|153792195 DKFZP434H0735 protein [Homo sapiens]                    3295   0.0  
gi|171906559 peripheral benzodiazepine receptor-associated prote...   370   e-102
gi|140561070 RIM-binding protein 2 [Homo sapiens]                     304   4e-82
gi|171906567 peripheral benzodiazepine receptor-associated prote...   270   6e-72
gi|22035604 mitogen-activated protein kinase kinase kinase kinas...    79   4e-14
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        73   2e-12
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        73   2e-12
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         73   2e-12
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         73   2e-12
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         73   2e-12
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         73   2e-12
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         73   2e-12
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         73   2e-12
gi|22035602 mitogen-activated protein kinase kinase kinase kinas...    72   4e-12
gi|22035606 mitogen-activated protein kinase kinase kinase kinas...    70   1e-11
gi|56549694 enabled homolog isoform a [Homo sapiens]                   62   5e-09
gi|39930375 enabled homolog isoform b [Homo sapiens]                   62   5e-09
gi|157502225 Janus kinase and microtubule interacting protein 3 ...    62   6e-09
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap...    61   1e-08
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap...    61   1e-08
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap...    61   1e-08
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi...    61   1e-08
gi|148746195 trichohyalin [Homo sapiens]                               60   2e-08
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa...    58   7e-08
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa...    58   7e-08
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa...    58   7e-08
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap...    58   7e-08
gi|41152097 DNA segment on chromosome X and Y (unique) 155 expre...    57   1e-07

>gi|191252814 RIMS binding protein 3B [Homo sapiens]
          Length = 1639

 Score = 3322 bits (8614), Expect = 0.0
 Identities = 1639/1639 (100%), Positives = 1639/1639 (100%)

Query: 1    MAKDSPSPLGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQ 60
            MAKDSPSPLGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQ
Sbjct: 1    MAKDSPSPLGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQ 60

Query: 61   LREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQL 120
            LREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQL
Sbjct: 61   LREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQL 120

Query: 121  LHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGE 180
            LHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGE
Sbjct: 121  LHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGE 180

Query: 181  QAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAP 240
            QAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAP
Sbjct: 181  QAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAP 240

Query: 241  KPACQLGSLDSLSAEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTR 300
            KPACQLGSLDSLSAEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTR
Sbjct: 241  KPACQLGSLDSLSAEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTR 300

Query: 301  SLPKASKSEERPSSPDTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEV 360
            SLPKASKSEERPSSPDTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEV
Sbjct: 301  SLPKASKSEERPSSPDTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEV 360

Query: 361  LTPSPPGLGHHELIKLNWLLAKALWVLARRCYTLQEENKQLRRAGCPYQADEKVKRLKVK 420
            LTPSPPGLGHHELIKLNWLLAKALWVLARRCYTLQEENKQLRRAGCPYQADEKVKRLKVK
Sbjct: 361  LTPSPPGLGHHELIKLNWLLAKALWVLARRCYTLQEENKQLRRAGCPYQADEKVKRLKVK 420

Query: 421  RAELTGLARRLADRARELQETNLRAVSAPIPGESCAGLELCQVFARQRARDLSEQASAPL 480
            RAELTGLARRLADRARELQETNLRAVSAPIPGESCAGLELCQVFARQRARDLSEQASAPL
Sbjct: 421  RAELTGLARRLADRARELQETNLRAVSAPIPGESCAGLELCQVFARQRARDLSEQASAPL 480

Query: 481  AKDKQIEELRQECHLLQARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQ 540
            AKDKQIEELRQECHLLQARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQ
Sbjct: 481  AKDKQIEELRQECHLLQARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQ 540

Query: 541  RQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRRECQELGTQAAPARRRGEE 600
            RQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRRECQELGTQAAPARRRGEE
Sbjct: 541  RQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRRECQELGTQAAPARRRGEE 600

Query: 601  AETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQL 660
            AETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQL
Sbjct: 601  AETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQL 660

Query: 661  LQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKGS 720
            LQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKGS
Sbjct: 661  LQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKGS 720

Query: 721  RRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTS 780
            RRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTS
Sbjct: 721  RRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTS 780

Query: 781  SQSNSSSEGSMWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGSAAPAAPKLKIFMAQ 840
            SQSNSSSEGSMWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGSAAPAAPKLKIFMAQ
Sbjct: 781  SQSNSSSEGSMWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGSAAPAAPKLKIFMAQ 840

Query: 841  YNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELDDGRRGLVPSNFVEQIPDS 900
            YNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELDDGRRGLVPSNFVEQIPDS
Sbjct: 841  YNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELDDGRRGLVPSNFVEQIPDS 900

Query: 901  YIPGCLPAKSPDLGPSQLPAGQDEALEEDSLLSGKAQGMVDRGLCQMVRVGSKTEVATEI 960
            YIPGCLPAKSPDLGPSQLPAGQDEALEEDSLLSGKAQGMVDRGLCQMVRVGSKTEVATEI
Sbjct: 901  YIPGCLPAKSPDLGPSQLPAGQDEALEEDSLLSGKAQGMVDRGLCQMVRVGSKTEVATEI 960

Query: 961  LDTKTEACQLGLLQSMGKQGLSRPLLGTKGVLRMAPMQLHLQNVTATSANITWVYSSHRH 1020
            LDTKTEACQLGLLQSMGKQGLSRPLLGTKGVLRMAPMQLHLQNVTATSANITWVYSSHRH
Sbjct: 961  LDTKTEACQLGLLQSMGKQGLSRPLLGTKGVLRMAPMQLHLQNVTATSANITWVYSSHRH 1020

Query: 1021 PHVVYLDDREHALTPAGVSCYTFQGLCPGTHYRVRVEVRLPWDLLQVYWGTMSSTVTFDT 1080
            PHVVYLDDREHALTPAGVSCYTFQGLCPGTHYRVRVEVRLPWDLLQVYWGTMSSTVTFDT
Sbjct: 1021 PHVVYLDDREHALTPAGVSCYTFQGLCPGTHYRVRVEVRLPWDLLQVYWGTMSSTVTFDT 1080

Query: 1081 LLAGPPYPPLEVLVERHASPGVLVVSWLPVTIDSAGSSNGVQVTGYAVYADGLKVCEVAD 1140
            LLAGPPYPPLEVLVERHASPGVLVVSWLPVTIDSAGSSNGVQVTGYAVYADGLKVCEVAD
Sbjct: 1081 LLAGPPYPPLEVLVERHASPGVLVVSWLPVTIDSAGSSNGVQVTGYAVYADGLKVCEVAD 1140

Query: 1141 ATAGSTVLEFSQLQVPLTWQKVSVRTMSLCGESLDSVPAQIPEDFFMCHRWPETPPFSYT 1200
            ATAGSTVLEFSQLQVPLTWQKVSVRTMSLCGESLDSVPAQIPEDFFMCHRWPETPPFSYT
Sbjct: 1141 ATAGSTVLEFSQLQVPLTWQKVSVRTMSLCGESLDSVPAQIPEDFFMCHRWPETPPFSYT 1200

Query: 1201 CGDPSTYRVTFPVCPQKLSLAPPSAKASPHNPGSCGEPQAKFLEAFFEEPPRRQSPVSNL 1260
            CGDPSTYRVTFPVCPQKLSLAPPSAKASPHNPGSCGEPQAKFLEAFFEEPPRRQSPVSNL
Sbjct: 1201 CGDPSTYRVTFPVCPQKLSLAPPSAKASPHNPGSCGEPQAKFLEAFFEEPPRRQSPVSNL 1260

Query: 1261 GSEGECPSSGAGSQAQELAEAWEGCRKDLLFQKSPQNHRPPSVSDQPGEKENCYQHMGTS 1320
            GSEGECPSSGAGSQAQELAEAWEGCRKDLLFQKSPQNHRPPSVSDQPGEKENCYQHMGTS
Sbjct: 1261 GSEGECPSSGAGSQAQELAEAWEGCRKDLLFQKSPQNHRPPSVSDQPGEKENCYQHMGTS 1320

Query: 1321 KSPAPGFIHLRTECGPRKEPCQEKAALERVLRQKQDAQGFTPPQLGASQQYASDFHNVLK 1380
            KSPAPGFIHLRTECGPRKEPCQEKAALERVLRQKQDAQGFTPPQLGASQQYASDFHNVLK
Sbjct: 1321 KSPAPGFIHLRTECGPRKEPCQEKAALERVLRQKQDAQGFTPPQLGASQQYASDFHNVLK 1380

Query: 1381 EEQEALCLDLRGTERREERREPEPHSRQGQALGVKRGCQLHEPSSALCPAPSAKVIKMPR 1440
            EEQEALCLDLRGTERREERREPEPHSRQGQALGVKRGCQLHEPSSALCPAPSAKVIKMPR
Sbjct: 1381 EEQEALCLDLRGTERREERREPEPHSRQGQALGVKRGCQLHEPSSALCPAPSAKVIKMPR 1440

Query: 1441 GGPQQLGTGANTPARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYL 1500
            GGPQQLGTGANTPARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYL
Sbjct: 1441 GGPQQLGTGANTPARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYL 1500

Query: 1501 SECNRQVGNIPGRLVAEMEVGTEQTDRRWRSPAQGHLPSVAHLEDFQGLTIPQGSSLVLQ 1560
            SECNRQVGNIPGRLVAEMEVGTEQTDRRWRSPAQGHLPSVAHLEDFQGLTIPQGSSLVLQ
Sbjct: 1501 SECNRQVGNIPGRLVAEMEVGTEQTDRRWRSPAQGHLPSVAHLEDFQGLTIPQGSSLVLQ 1560

Query: 1561 GNSKRLPLWTPKIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGELG 1620
            GNSKRLPLWTPKIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGELG
Sbjct: 1561 GNSKRLPLWTPKIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGELG 1620

Query: 1621 GHRGLVPAHLLDHMSLHGH 1639
            GHRGLVPAHLLDHMSLHGH
Sbjct: 1621 GHRGLVPAHLLDHMSLHGH 1639


>gi|191252806 RIMS binding protein 3C [Homo sapiens]
          Length = 1639

 Score = 3319 bits (8605), Expect = 0.0
 Identities = 1637/1639 (99%), Positives = 1638/1639 (99%)

Query: 1    MAKDSPSPLGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQ 60
            MAKDSPSPLGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQ
Sbjct: 1    MAKDSPSPLGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQ 60

Query: 61   LREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQL 120
            LREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQL
Sbjct: 61   LREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQL 120

Query: 121  LHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGE 180
            LHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGE
Sbjct: 121  LHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGE 180

Query: 181  QAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAP 240
            QAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAP
Sbjct: 181  QAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAP 240

Query: 241  KPACQLGSLDSLSAEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTR 300
            KPACQLGSLDSLSAEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTR
Sbjct: 241  KPACQLGSLDSLSAEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTR 300

Query: 301  SLPKASKSEERPSSPDTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEV 360
            SLPKASKSEERPSSPDTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEV
Sbjct: 301  SLPKASKSEERPSSPDTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEV 360

Query: 361  LTPSPPGLGHHELIKLNWLLAKALWVLARRCYTLQEENKQLRRAGCPYQADEKVKRLKVK 420
            LTPSPPGLGHHELIKLNWLLAKALWVLARRCYTLQEENKQLRRAGCPYQADEKVKRLKVK
Sbjct: 361  LTPSPPGLGHHELIKLNWLLAKALWVLARRCYTLQEENKQLRRAGCPYQADEKVKRLKVK 420

Query: 421  RAELTGLARRLADRARELQETNLRAVSAPIPGESCAGLELCQVFARQRARDLSEQASAPL 480
            RAELTGLARRLADRARELQETNLRAVSAPIPGESCAGLELCQVFARQRARDLSEQASAPL
Sbjct: 421  RAELTGLARRLADRARELQETNLRAVSAPIPGESCAGLELCQVFARQRARDLSEQASAPL 480

Query: 481  AKDKQIEELRQECHLLQARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQ 540
            AKDKQIEELRQECHLLQARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQ
Sbjct: 481  AKDKQIEELRQECHLLQARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQ 540

Query: 541  RQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRRECQELGTQAAPARRRGEE 600
            RQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRRECQELGTQAAPARRRGEE
Sbjct: 541  RQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRRECQELGTQAAPARRRGEE 600

Query: 601  AETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQL 660
            AETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQL
Sbjct: 601  AETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQL 660

Query: 661  LQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKGS 720
            LQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKGS
Sbjct: 661  LQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKGS 720

Query: 721  RRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTS 780
            RRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTS
Sbjct: 721  RRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTS 780

Query: 781  SQSNSSSEGSMWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGSAAPAAPKLKIFMAQ 840
            SQSNSSSEGSMWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGSAAPAAPKLKIFMAQ
Sbjct: 781  SQSNSSSEGSMWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGSAAPAAPKLKIFMAQ 840

Query: 841  YNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELDDGRRGLVPSNFVEQIPDS 900
            YNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELDDGRRGLVPSNFVEQIPDS
Sbjct: 841  YNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELDDGRRGLVPSNFVEQIPDS 900

Query: 901  YIPGCLPAKSPDLGPSQLPAGQDEALEEDSLLSGKAQGMVDRGLCQMVRVGSKTEVATEI 960
            YIPGCLPAKSPDLGPSQLPAGQDEALEEDSLLSGKAQGMVDRGLCQMVRVGSKTEVATEI
Sbjct: 901  YIPGCLPAKSPDLGPSQLPAGQDEALEEDSLLSGKAQGMVDRGLCQMVRVGSKTEVATEI 960

Query: 961  LDTKTEACQLGLLQSMGKQGLSRPLLGTKGVLRMAPMQLHLQNVTATSANITWVYSSHRH 1020
            LDTKTEACQLGLLQSMGKQGLSRPLLGTKGVLRMAPMQLHLQNVTATSANITWVYSSHRH
Sbjct: 961  LDTKTEACQLGLLQSMGKQGLSRPLLGTKGVLRMAPMQLHLQNVTATSANITWVYSSHRH 1020

Query: 1021 PHVVYLDDREHALTPAGVSCYTFQGLCPGTHYRVRVEVRLPWDLLQVYWGTMSSTVTFDT 1080
            PHVVYLDDREHALTPAGVSCYTFQGLCPGTHYRVRVEVRLPWDLLQVYWGTMSSTVTFDT
Sbjct: 1021 PHVVYLDDREHALTPAGVSCYTFQGLCPGTHYRVRVEVRLPWDLLQVYWGTMSSTVTFDT 1080

Query: 1081 LLAGPPYPPLEVLVERHASPGVLVVSWLPVTIDSAGSSNGVQVTGYAVYADGLKVCEVAD 1140
            LLAGPPYPPL+VLVERHASPGVLVVSWLPVTIDSAGSSNGVQVTGYAVYADGLKVCEVAD
Sbjct: 1081 LLAGPPYPPLDVLVERHASPGVLVVSWLPVTIDSAGSSNGVQVTGYAVYADGLKVCEVAD 1140

Query: 1141 ATAGSTVLEFSQLQVPLTWQKVSVRTMSLCGESLDSVPAQIPEDFFMCHRWPETPPFSYT 1200
            ATAGSTVLEFSQLQVPLTWQKVSVRTMSLCGESLDSVPAQIPEDFFMCHRWPETPPFSYT
Sbjct: 1141 ATAGSTVLEFSQLQVPLTWQKVSVRTMSLCGESLDSVPAQIPEDFFMCHRWPETPPFSYT 1200

Query: 1201 CGDPSTYRVTFPVCPQKLSLAPPSAKASPHNPGSCGEPQAKFLEAFFEEPPRRQSPVSNL 1260
            CGDPSTYRVTFPVCPQKLSLAPPSAKASPHNPGSCGEPQAKFLEAFFEEPPRRQSPVSNL
Sbjct: 1201 CGDPSTYRVTFPVCPQKLSLAPPSAKASPHNPGSCGEPQAKFLEAFFEEPPRRQSPVSNL 1260

Query: 1261 GSEGECPSSGAGSQAQELAEAWEGCRKDLLFQKSPQNHRPPSVSDQPGEKENCYQHMGTS 1320
            GSEGECPSSGAGSQAQELAEAWEGCRKDLLFQKSPQNHRPPSVSDQPGEKENCYQHMGTS
Sbjct: 1261 GSEGECPSSGAGSQAQELAEAWEGCRKDLLFQKSPQNHRPPSVSDQPGEKENCYQHMGTS 1320

Query: 1321 KSPAPGFIHLRTECGPRKEPCQEKAALERVLRQKQDAQGFTPPQLGASQQYASDFHNVLK 1380
            KSPAPGFIHLRTECGPRKEPCQEKAALERVLRQKQDAQGFTPPQLGASQQYASDFHNVLK
Sbjct: 1321 KSPAPGFIHLRTECGPRKEPCQEKAALERVLRQKQDAQGFTPPQLGASQQYASDFHNVLK 1380

Query: 1381 EEQEALCLDLRGTERREERREPEPHSRQGQALGVKRGCQLHEPSSALCPAPSAKVIKMPR 1440
            EEQEALCLDLRGTERREERREPEPHSRQGQALGVKRGCQLHEPSSALCPAPSAKVIKMPR
Sbjct: 1381 EEQEALCLDLRGTERREERREPEPHSRQGQALGVKRGCQLHEPSSALCPAPSAKVIKMPR 1440

Query: 1441 GGPQQLGTGANTPARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYL 1500
            GGPQQLGTGANTPARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYL
Sbjct: 1441 GGPQQLGTGANTPARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYL 1500

Query: 1501 SECNRQVGNIPGRLVAEMEVGTEQTDRRWRSPAQGHLPSVAHLEDFQGLTIPQGSSLVLQ 1560
            SECNRQVGNIPGRLVAEMEVGTEQTDRRWRSPAQGHLPSVAHLEDFQGL IPQGSSLVLQ
Sbjct: 1501 SECNRQVGNIPGRLVAEMEVGTEQTDRRWRSPAQGHLPSVAHLEDFQGLIIPQGSSLVLQ 1560

Query: 1561 GNSKRLPLWTPKIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGELG 1620
            GNSKRLPLWTPKIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGELG
Sbjct: 1561 GNSKRLPLWTPKIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGELG 1620

Query: 1621 GHRGLVPAHLLDHMSLHGH 1639
            GHRGLVPAHLLDHMSLHGH
Sbjct: 1621 GHRGLVPAHLLDHMSLHGH 1639


>gi|153792195 DKFZP434H0735 protein [Homo sapiens]
          Length = 1639

 Score = 3295 bits (8543), Expect = 0.0
 Identities = 1627/1639 (99%), Positives = 1633/1639 (99%)

Query: 1    MAKDSPSPLGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQ 60
            MAKDSPSPLGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQ
Sbjct: 1    MAKDSPSPLGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQ 60

Query: 61   LREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQL 120
            LREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQL
Sbjct: 61   LREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQL 120

Query: 121  LHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGE 180
            LHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGE
Sbjct: 121  LHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGE 180

Query: 181  QAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAP 240
            QAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAP
Sbjct: 181  QAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAP 240

Query: 241  KPACQLGSLDSLSAEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTR 300
            KPACQLGSLDSLSAEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTR
Sbjct: 241  KPACQLGSLDSLSAEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTR 300

Query: 301  SLPKASKSEERPSSPDTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEV 360
            SLPKASKSEERPSSPDTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEV
Sbjct: 301  SLPKASKSEERPSSPDTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEV 360

Query: 361  LTPSPPGLGHHELIKLNWLLAKALWVLARRCYTLQEENKQLRRAGCPYQADEKVKRLKVK 420
            LTPSPPGLGHHELIKLNWLLAKALWVLARRCYTLQ ENKQLRRAGCPYQADEKVKRLKVK
Sbjct: 361  LTPSPPGLGHHELIKLNWLLAKALWVLARRCYTLQAENKQLRRAGCPYQADEKVKRLKVK 420

Query: 421  RAELTGLARRLADRARELQETNLRAVSAPIPGESCAGLELCQVFARQRARDLSEQASAPL 480
            RAELTGLARRLADRAR+LQETNLRAVSAPIPGESCAGLELCQVFARQRARDLSEQASAPL
Sbjct: 421  RAELTGLARRLADRARKLQETNLRAVSAPIPGESCAGLELCQVFARQRARDLSEQASAPL 480

Query: 481  AKDKQIEELRQECHLLQARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQ 540
            AKDKQIEELRQECHLLQARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQ
Sbjct: 481  AKDKQIEELRQECHLLQARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQ 540

Query: 541  RQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRRECQELGTQAAPARRRGEE 600
            RQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRRECQELG QAAPARRRGEE
Sbjct: 541  RQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRRECQELGAQAAPARRRGEE 600

Query: 601  AETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQL 660
            AETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQL
Sbjct: 601  AETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQL 660

Query: 661  LQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKGS 720
            LQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKGS
Sbjct: 661  LQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKGS 720

Query: 721  RRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTS 780
            RRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTS
Sbjct: 721  RRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTS 780

Query: 781  SQSNSSSEGSMWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGSAAPAAPKLKIFMAQ 840
            SQSNSSSEGSMWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGSAAPAAPKLKIFMAQ
Sbjct: 781  SQSNSSSEGSMWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGSAAPAAPKLKIFMAQ 840

Query: 841  YNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELDDGRRGLVPSNFVEQIPDS 900
            YNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGEL+DGRRGLVPSNFVEQIPDS
Sbjct: 841  YNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELEDGRRGLVPSNFVEQIPDS 900

Query: 901  YIPGCLPAKSPDLGPSQLPAGQDEALEEDSLLSGKAQGMVDRGLCQMVRVGSKTEVATEI 960
            YIPGCLPAKSPDLGPSQLPAGQDEALEEDSLLSGKAQG+VDRGLCQMVRVGSKTEVATEI
Sbjct: 901  YIPGCLPAKSPDLGPSQLPAGQDEALEEDSLLSGKAQGVVDRGLCQMVRVGSKTEVATEI 960

Query: 961  LDTKTEACQLGLLQSMGKQGLSRPLLGTKGVLRMAPMQLHLQNVTATSANITWVYSSHRH 1020
            LDTKTEACQLGLLQSMGKQGLSRPLLGTKGVLRMAPMQLHLQNVTATSANITWVYSSHRH
Sbjct: 961  LDTKTEACQLGLLQSMGKQGLSRPLLGTKGVLRMAPMQLHLQNVTATSANITWVYSSHRH 1020

Query: 1021 PHVVYLDDREHALTPAGVSCYTFQGLCPGTHYRVRVEVRLPWDLLQVYWGTMSSTVTFDT 1080
            PHVVYLDDREHALTPAGVSCYTFQGLCPGTHYR RVEVRLP DLLQVYWGTMSSTVTFDT
Sbjct: 1021 PHVVYLDDREHALTPAGVSCYTFQGLCPGTHYRARVEVRLPRDLLQVYWGTMSSTVTFDT 1080

Query: 1081 LLAGPPYPPLEVLVERHASPGVLVVSWLPVTIDSAGSSNGVQVTGYAVYADGLKVCEVAD 1140
            LLAGPPYPPL+VLVERHASPGVLVVSWLPVTIDSAGSSNGVQVTGYAVYADGLKVCEVAD
Sbjct: 1081 LLAGPPYPPLDVLVERHASPGVLVVSWLPVTIDSAGSSNGVQVTGYAVYADGLKVCEVAD 1140

Query: 1141 ATAGSTVLEFSQLQVPLTWQKVSVRTMSLCGESLDSVPAQIPEDFFMCHRWPETPPFSYT 1200
            ATAGST+LEFSQLQVPLTWQKVSVRTMSLCGESLDSVPAQIPEDFFMCHRWPETPPFSYT
Sbjct: 1141 ATAGSTLLEFSQLQVPLTWQKVSVRTMSLCGESLDSVPAQIPEDFFMCHRWPETPPFSYT 1200

Query: 1201 CGDPSTYRVTFPVCPQKLSLAPPSAKASPHNPGSCGEPQAKFLEAFFEEPPRRQSPVSNL 1260
            CGDPSTYRVTFPVCPQKLSLAPPSAKASPHNPGSCGEPQAKFLEAFFEEPPRRQSPVSNL
Sbjct: 1201 CGDPSTYRVTFPVCPQKLSLAPPSAKASPHNPGSCGEPQAKFLEAFFEEPPRRQSPVSNL 1260

Query: 1261 GSEGECPSSGAGSQAQELAEAWEGCRKDLLFQKSPQNHRPPSVSDQPGEKENCYQHMGTS 1320
            GSEGECPSSGAGSQAQELAEAWEGCRKDLLFQKSPQNHRPPSVSDQPGEKENC QHMGTS
Sbjct: 1261 GSEGECPSSGAGSQAQELAEAWEGCRKDLLFQKSPQNHRPPSVSDQPGEKENCSQHMGTS 1320

Query: 1321 KSPAPGFIHLRTECGPRKEPCQEKAALERVLRQKQDAQGFTPPQLGASQQYASDFHNVLK 1380
            KSPAPGFIHLRTECGPRKEPCQEKAALERVLRQKQDAQGFTPPQLGASQQYASDFHNVLK
Sbjct: 1321 KSPAPGFIHLRTECGPRKEPCQEKAALERVLRQKQDAQGFTPPQLGASQQYASDFHNVLK 1380

Query: 1381 EEQEALCLDLRGTERREERREPEPHSRQGQALGVKRGCQLHEPSSALCPAPSAKVIKMPR 1440
            EEQEALCLDL GTERREERREPEPHSRQGQALGVKRGCQLHEPSSALCPAPSAKVIKMPR
Sbjct: 1381 EEQEALCLDLWGTERREERREPEPHSRQGQALGVKRGCQLHEPSSALCPAPSAKVIKMPR 1440

Query: 1441 GGPQQLGTGANTPARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYL 1500
            GGPQQLGTGANTPARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYL
Sbjct: 1441 GGPQQLGTGANTPARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYL 1500

Query: 1501 SECNRQVGNIPGRLVAEMEVGTEQTDRRWRSPAQGHLPSVAHLEDFQGLTIPQGSSLVLQ 1560
            SECNRQVGNIPGRLVAEMEVGTEQTDRRWRSPAQG+LPSVAHLEDFQGLTIPQGSSLVLQ
Sbjct: 1501 SECNRQVGNIPGRLVAEMEVGTEQTDRRWRSPAQGNLPSVAHLEDFQGLTIPQGSSLVLQ 1560

Query: 1561 GNSKRLPLWTPKIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGELG 1620
            GNSKRLPLWTPKIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGELG
Sbjct: 1561 GNSKRLPLWTPKIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGELG 1620

Query: 1621 GHRGLVPAHLLDHMSLHGH 1639
            GHRGLVPAHLLDHMSLHGH
Sbjct: 1621 GHRGLVPAHLLDHMSLHGH 1639


>gi|171906559 peripheral benzodiazepine receptor-associated protein 1
            isoform a [Homo sapiens]
          Length = 1857

 Score =  370 bits (949), Expect = e-102
 Identities = 368/1148 (32%), Positives = 519/1148 (45%), Gaps = 220/1148 (19%)

Query: 377  NWLLAKALWVLARRCYTLQEENKQLRRAGCPYQADEKVKRLKVKRAELTGLARRLADRAR 436
            N  L +AL  L +RC  L+EEN+ LR++  P + +EKV+RLK K AEL  +A+RL +RAR
Sbjct: 123  NLELLRALGELRQRCAILKEENQMLRKSSFP-ETEEKVRRLKRKNAELAVIAKRLEERAR 181

Query: 437  ELQETNLRAVSAPIPGESCAGLELCQ-VFARQRARDLSEQASAPLAKDKQIEELRQECHL 495
            +LQETNLR VSAP+P    + LELC+   ARQRARDLSE ASA LAKDKQI  L++EC  
Sbjct: 182  KLQETNLRVVSAPLPRPGTS-LELCRKALARQRARDLSETASALLAKDKQIAALQRECRE 240

Query: 496  LQARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQ--------- 546
            LQAR+          G+ GP  QWL+VRD DRL RESQREVLRLQRQ+ L+         
Sbjct: 241  LQARLTL-------VGKEGP--QWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLP 291

Query: 547  ---------QGNGGA-WPEAGGQSATCE------------EVRRQMLALERELDQRRREC 584
                     Q   GA  P A G++   E            E  +++  LE EL ++R++C
Sbjct: 292  PSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKC 351

Query: 585  QELGTQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLG 644
            + L  +A   +RR EE E QL+ A  +NA L EEN RL  +     +VE EN+E+RG L 
Sbjct: 352  ESLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLL 411

Query: 645  RACQERDAS-----GLIA-----EQLLQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQA 694
               QERD++     GL +     EQ+L+       R+QQL+ + ++A   L    +E++ 
Sbjct: 412  GVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRR 471

Query: 695  LQCRPGHPPEQPWETSQMPESQVKGS----RRPKFHARPEDYAVSQPNRDIQEKREASLE 750
            LQ        +     Q+ ES +       R  +   R +    S   +++Q  R   L 
Sbjct: 472  LQQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFR---LH 528

Query: 751  ESPVALGESA----------------SVPQV-----------------------SETVPA 771
              P+ L  SA                S+PQ                        SE  PA
Sbjct: 529  PGPLDLLTSALDCGSLGDCPPPPCCCSIPQPCRGSGPKDLDLPPGSPGRCTPKSSEPAPA 588

Query: 772  S-----QPLSKKTSSQSNSSSEGSMWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGS 826
            +     +  +KK  S SNSS   S+  +  S PT + DTASEV++LE DSVSL L     
Sbjct: 589  TLTGVPRRTAKKAESLSNSSHSESIHNSPKSCPTPEVDTASEVEELEADSVSL-LPAAPE 647

Query: 827  AAPAAPKLKIFMAQYNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELDDGRR 886
             +    ++++F+A+Y+YNPFEGPN++PE ELPLTAG+YIYI+G+MDEDGF+EGEL DGRR
Sbjct: 648  GSRGGARIQVFLARYSYNPFEGPNENPEAELPLTAGEYIYIYGNMDEDGFFEGELMDGRR 707

Query: 887  GLVPSNFVEQIPDSYIPGCLPAKSPDL---------------------GPSQLPAGQDEA 925
            GLVPSNFVE++ D  +   LP +  DL                     G S +   Q   
Sbjct: 708  GLVPSNFVERVSDDDLLTSLPPELADLSHSSGPELSFLSVGGGGSSSGGQSSVGRSQPRP 767

Query: 926  LEEDS----LLSGKAQGMVD-------RGLCQMVRVGSKTEVATEILDTKTE-----ACQ 969
             EED+     LS   +G+ +       R L  + ++     +A E    + E      C 
Sbjct: 768  EEEDAGDELSLSPSPEGLGEPPAVPYPRRLVVLKQLAHSVVLAWEPPPEQVELHGFHICV 827

Query: 970  LG-LLQSMGKQGLSRPLLGTKGVLRMAPMQLHLQNVTA--TSANITWVYSSHRHPHVVYL 1026
             G L Q++G     + +L     L   P+ + +Q +T+  +S  +    +      VV  
Sbjct: 828  NGELRQALGPGAPPKAVLENLD-LWAGPLHISVQALTSRGSSDPLRCCLAVGARAGVVPS 886

Query: 1027 DDREHALTPAGVSCYTFQGLCPGTHYRVRVEVRLPWDLLQVYWGTM---------SSTVT 1077
              R H LT          G     H         P      YW T           + V 
Sbjct: 887  QLRVHRLTATSAEITWVPGNSNLAHAIYLNGEECPPASPSTYWATFCHLRPGTPYQAQVE 946

Query: 1078 FDTLLAGPPYPPLEVLVERHASPGVLVVSWLPVTIDSA--------GSSNGVQVTGY--- 1126
                  GP  P  E L +R A+   L  + LP     A        G S G+ +  +   
Sbjct: 947  AQLPPQGPWEPGWERLEQRAAT---LQFTTLPAGPPDAPLDVQIEPGPSPGILIISWLPV 1003

Query: 1127 ----AVYADGLKVCEVADATAGSTVL------------EFSQLQVPLTWQKVSVRTMSLC 1170
                A  ++G++V   A    G  ++            E SQLQ+    ++V VRTMS  
Sbjct: 1004 TIDAAGTSNGVRVTGYAIYADGQKIMEVASPTAGSVLVELSQLQLLQVCREVVVRTMSPH 1063

Query: 1171 GESLDSVPAQIPEDFFMCHRWPETPPFSYTC--------------------GDPST-YRV 1209
            GES DS+PA I          P + P   +C                    GDPS+  + 
Sbjct: 1064 GESADSIPAPITPALA-----PASLPARVSCPSPHPSPEARAPLASASPGPGDPSSPLQH 1118

Query: 1210 TFPVCPQKLSLAPPSAKASPHNPGSCGEPQAKFLE-----AFFEEPPRRQSPVSNLGSEG 1264
              P+  Q+   APP++ +     GS  +P A   +     A       R +  S LG + 
Sbjct: 1119 PAPLGTQEPPGAPPASPSREMAKGSHEDPPAPCSQEEAGAAVLGTSEERTASTSTLGEKD 1178

Query: 1265 ECPSSGAGSQAQELAE--AWEGCRKDLLFQKSPQNHRPPSVSDQPGEKENCYQHMGTSKS 1322
              P   A S A++ AE  A E C      Q +     P +   Q G+  +  +     + 
Sbjct: 1179 --PGPAAPSLAKQEAEWTAGEACPASSSTQGARAQQAPNTEMCQGGDPGSGLRPRAEKED 1236

Query: 1323 PAPGFIHL 1330
             A   +HL
Sbjct: 1237 TAELGVHL 1244



 Score =  127 bits (319), Expect = 9e-29
 Identities = 97/265 (36%), Positives = 130/265 (49%), Gaps = 37/265 (13%)

Query: 1391 RGTERREERREPEPHSRQGQALGVKRGCQLHEPSSA-LCPAPSAKVIKMPRGGPQQLGTG 1449
            R TE  E R +     R  Q    KRG ++  PS+A L PA S          P +    
Sbjct: 1577 RATETGEARGQDGSGRRGPQ----KRGVRVLRPSTAELVPARS----------PSETLAY 1622

Query: 1450 ANTPARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYLSECNRQVGN 1509
             + P R+FVAL DY+P+ MS N  A EEEL F++ Q+L+V+G +D   FY  E   + G 
Sbjct: 1623 QHLPVRIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRTGY 1682

Query: 1510 IPGRLVAEMEV----GTEQT-DRRWRSP-----AQGHLPSVAHLEDFQG---------LT 1550
            IP  +VAE+ V    G +Q   R + SP       G+ P V       G           
Sbjct: 1683 IPCNMVAEVAVDSPAGRQQLLQRGYLSPDILLEGSGNGPFVYSTAHTTGPPPKPRRSKKA 1742

Query: 1551 IPQGSSLVLQGNSKRLP---LWTPKIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYG 1607
              +G +    G  K +P   L  P  M+AA DY+P +       +  L  RAGDV+ V+G
Sbjct: 1743 ESEGPAQPCPGPPKLVPSADLKAPHSMVAAFDYNPQESSPNMDVEAELPFRAGDVITVFG 1802

Query: 1608 PMDDQGFYYGELGGHRGLVPAHLLD 1632
             MDD GFYYGEL G RGLVP++ L+
Sbjct: 1803 GMDDDGFYYGELNGQRGLVPSNFLE 1827



 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 36/59 (61%), Positives = 44/59 (74%), Gaps = 2/59 (3%)

Query: 838  MAQYNYNPFEG-PNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELDDGRRGLVPSNFVE 895
            +A ++YNP E  PN   E ELP  AGD I +FG MD+DGFY GEL +G+RGLVPSNF+E
Sbjct: 1770 VAAFDYNPQESSPNMDVEAELPFRAGDVITVFGGMDDDGFYYGEL-NGQRGLVPSNFLE 1827



 Score = 58.2 bits (139), Expect = 7e-08
 Identities = 65/219 (29%), Positives = 90/219 (41%), Gaps = 41/219 (18%)

Query: 723  PKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTSSQ 782
            PK ++ P+ Y    P     EK E      P   G SA       T  A +PLS+ T + 
Sbjct: 1540 PKANSGPKPY----PRLPAWEKGE------PERRGRSA-------TGRAKEPLSRATETG 1582

Query: 783  SNSSSEGS-MWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGSAAPAAPKLKIFMAQY 841
                 +GS           + R + +E+      S +LA +           ++IF+A +
Sbjct: 1583 EARGQDGSGRRGPQKRGVRVLRPSTAELVPARSPSETLAYQH--------LPVRIFVALF 1634

Query: 842  NYNPFE-GPN-DHPEGELPLTAGDYIYIFGDMDEDGFYEGELDDGRRGLVPSNFVEQIPD 899
            +Y+P    PN D  E ELP   G  + +FGD D DGFY+GE   GR G +P N V ++  
Sbjct: 1635 DYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGE-GGGRTGYIPCNMVAEV-- 1691

Query: 900  SYIPGCLPAKSPDLGPSQLPAGQDEALEEDSLLSGKAQG 938
                    A     G  QL   Q   L  D LL G   G
Sbjct: 1692 --------AVDSPAGRQQLL--QRGYLSPDILLEGSGNG 1720



 Score = 48.9 bits (115), Expect = 4e-05
 Identities = 24/65 (36%), Positives = 40/65 (61%), Gaps = 2/65 (3%)

Query: 1572 KIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGEL-GGHRGLVPAHL 1630
            ++ +A   Y+P +G      +  L L AG+ + +YG MD+ GF+ GEL  G RGLVP++ 
Sbjct: 656  QVFLARYSYNPFEGP-NENPEAELPLTAGEYIYIYGNMDEDGFFEGELMDGRRGLVPSNF 714

Query: 1631 LDHMS 1635
            ++ +S
Sbjct: 715  VERVS 719



 Score = 48.1 bits (113), Expect = 7e-05
 Identities = 86/370 (23%), Positives = 141/370 (38%), Gaps = 63/370 (17%)

Query: 6   PSP-LGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARER--QLR 62
           P P L A    P   +P  A  +     L  +  E E E+   + E      R++   L 
Sbjct: 296 PGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLE 355

Query: 63  EEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLH 122
           +EA +++R+  + L  +    ++   R ++E  +    A  ++ + W+ AE R     + 
Sbjct: 356 QEARKKQRR-CEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVT 414

Query: 123 RERDGVVRQARELQRQL--AEELVN--RGHCSRPGASEVSAAQCRC----------RLQE 168
           +ERD  +R+++ LQ +L   E+++   R    R    EV   Q R           RLQ+
Sbjct: 415 QERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQ 474

Query: 169 VLAQLRWQTDG----------EQAARIRYL--QAALEVERQLFLKYILAHFRGHP----- 211
             A+ + + +G             AR+R L  Q   + E+   L   L  FR HP     
Sbjct: 475 AQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRLHPGPLDL 534

Query: 212 --------ALSGSPDPQAVHSLEEP----------LPQTSSGSCHAPKPACQLGSLDSLS 253
                   +L   P P    S+ +P          LP  S G C  PK      S  + +
Sbjct: 535 LTSALDCGSLGDCPPPPCCCSIPQPCRGSGPKDLDLPPGSPGRC-TPK-----SSEPAPA 588

Query: 254 AEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPS 313
              GV  R+     S  +SS     S H S   C  P    + +      +A      P+
Sbjct: 589 TLTGVPRRTAKKAESLSNSSHSE--SIHNSPKSCPTPEVDTASEVEEL--EADSVSLLPA 644

Query: 314 SPDTSTPGSR 323
           +P+ S  G+R
Sbjct: 645 APEGSRGGAR 654



 Score = 46.2 bits (108), Expect = 3e-04
 Identities = 22/66 (33%), Positives = 35/66 (53%), Gaps = 1/66 (1%)

Query: 1572 KIMIAALDYDPGDGQMGGQ-GKGRLALRAGDVVMVYGPMDDQGFYYGELGGHRGLVPAHL 1630
            +I +A  DYDP         G+  L  R G ++ V+G  D  GFY GE GG  G +P ++
Sbjct: 1628 RIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRTGYIPCNM 1687

Query: 1631 LDHMSL 1636
            +  +++
Sbjct: 1688 VAEVAV 1693



 Score = 37.4 bits (85), Expect = 0.12
 Identities = 60/258 (23%), Positives = 100/258 (38%), Gaps = 35/258 (13%)

Query: 331 PLPP--PPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHHELIKLNWLLAKALWVLA 388
           PLPP  PP P+   +   P  G   E+ P E     P  LG  E  +    L   L    
Sbjct: 289 PLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKR 348

Query: 389 RRCYTLQEENKQLRRAGCPYQADEKVKRLKVKRAELTGLARRLADRARELQETNLRAVSA 448
           ++C +L++E ++ +R  C  + + ++++ + + A L     RL+ RA E ++      +A
Sbjct: 349 KKCESLEQEARKKQRR-CE-ELELQLRQAQNENARLVEENSRLSGRATEKEQVEWE--NA 404

Query: 449 PIPGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPCSDL 508
            + G+   G+   +  A ++++ L  +  +     K + E+ Q    L+        S  
Sbjct: 405 ELRGQ-LLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLS-- 461

Query: 509 HTGRGGPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRR 568
                                RE Q EV R      LQQ    A  E  G     E    
Sbjct: 462 --------------------LREKQEEVRR------LQQAQAEAQREHEGAVQLLESTLD 495

Query: 569 QMLALERELDQRRRECQE 586
            M A  REL+++ R   E
Sbjct: 496 SMQARVRELEEQCRSQTE 513


>gi|140561070 RIM-binding protein 2 [Homo sapiens]
          Length = 1052

 Score =  304 bits (779), Expect = 4e-82
 Identities = 305/1093 (27%), Positives = 463/1093 (42%), Gaps = 208/1093 (19%)

Query: 669  DRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKGSRRPKFHAR 728
            +R+QQLQ +  +AL  L    +EI  LQ             S++ E + K         R
Sbjct: 6    ERRQQLQLEHDQALAVLSAKQQEIDLLQ------------KSKVRELEEK--------CR 45

Query: 729  PEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTSSQSNSSSE 788
             +    +  +RD+++ R+ + +     LG SA  P    T P S+P  +  +  + S  +
Sbjct: 46   TQSEQFNLLSRDLEKFRQHAGKID--LLGGSAVAPLDISTAP-SKPFPQFMNGLATSLGK 102

Query: 789  GSMWATVPSSPTLD--RDTASEVDDLEPDSVSLA-LEMGGSAAPAAP------------- 832
            G   A   SS   +  R      D  EP S     L   GSA   +              
Sbjct: 103  GQESAIGGSSAIGEYIRPLPQPGDRPEPLSAKPTFLSRSGSARCRSESDMENERNSNTSK 162

Query: 833  -----KLKIFMAQYNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELDDGRRG 887
                 K+ + +A+Y+YNPF+GPN++PE ELPLTAG Y+Y++GDMDEDGFYEGEL DG+RG
Sbjct: 163  QRYSGKVHLCVARYSYNPFDGPNENPEAELPLTAGKYLYVYGDMDEDGFYEGELLDGQRG 222

Query: 888  LVPSNFV--------------------------------EQIPDSYIP------------ 903
            LVPSNFV                                E I D + P            
Sbjct: 223  LVPSNFVDFVQDNESRLASTLGNEQDQNFINHSGIGLEGEHILDLHSPTHIDAGITDNSA 282

Query: 904  GCLPAKSPDLGPSQLPAGQDEALEED---SLLSG--------------KAQGMVDRGLCQ 946
            G L     D+G   +P  +   L +    S++ G                  +VD+    
Sbjct: 283  GTLDVNIDDIGEDIVPYPRKITLIKQLAKSVIVGWEPPAVPPGWGTVSSYNVLVDKETRM 342

Query: 947  MVRVGSKTEVATEILDTKTEACQLGL-LQSMGKQGLSRPLLGTKGVLR---MAPMQLHLQ 1002
             + +GS+T+   E L+    AC   + +Q +  +G S  L  T  V +   +AP  L + 
Sbjct: 343  NLTLGSRTKALIEKLNMA--ACTYRISVQCVTSRGSSDELQCTLLVGKDVVVAPSHLRVD 400

Query: 1003 NVTATSANITWVYSSHRHPHVVYLDDREHALTPAGVSCYTFQGLCPGTHYRVRVEVR--- 1059
            N+T  SA ++W+ ++  + HV++L++ E  +  A    Y F  L P   Y+V+V  +   
Sbjct: 401  NITQISAQLSWLPTNSNYSHVIFLNEEEFDIVKAARYKYQFFNLRPNMAYKVKVLAKPHQ 460

Query: 1060 LPWDLLQVYWGTMSSTVTFDTLLAGPPYPPLEVLVERHASPGVLVVSWLPVTIDSAGSSN 1119
            +PW L         + V F TL AGPP PP +V V+   +P  + VSW P  +   G SN
Sbjct: 461  MPWQLPLEQREKKEAFVEFSTLPAGPPAPPQDVTVQAGVTPATIRVSWRPPVLTPTGLSN 520

Query: 1120 GVQVTGYAVYADGLKVCEVADATAGSTVLEFSQLQVPLTWQKVSVRTMSLCGESLDSVPA 1179
            G  VTGY VYA G +V EV   TA ST +E  +L+  L  + V+VRT+S  GES+DS  A
Sbjct: 521  GANVTGYGVYAKGQRVAEVIFPTADSTAVELVRLR-SLEAKGVTVRTLSAQGESVDSAVA 579

Query: 1180 QIPEDFFMCHRWPETPPFSYTCGDPSTYRVTFPVCPQKLS--LAPPSAKASPHNPGSCGE 1237
             +P +  +       PP  +    P +  +     P+     L P +             
Sbjct: 580  AVPPELLV-------PPTPHPRPAPQSKPLASSGVPETKDEHLGPHARMDEAWEQSRAPG 632

Query: 1238 PQAKFLEAFFEEPP-----RRQSPVSNLGSEGECPSSGAGSQAQELAEAWEGCRKDLLFQ 1292
            P    +     EPP     R  SP   L      P S   ++A     A        L +
Sbjct: 633  P----VHGHMLEPPVGPGRRSPSPSRILPQPQGTPVSTTVAKAMAREAAQRVAESSRLEK 688

Query: 1293 KSPQNHRPPSVSDQPGEKENCYQHMGTSKSPAPGFIHLR-TECGPRKEPCQEKAALERVL 1351
            +S    R  +      ++E+ Y      +  A     L+ +E G +   C          
Sbjct: 689  RSVFLERSSAGQYAASDEEDAYDSPDFKRRGASVDDFLKGSELGKQPHCCHGD------- 741

Query: 1352 RQKQDAQGFTPPQLGASQQYASDFHNVLKEEQEALCLDLRGTERREERREPEPHSRQGQA 1411
                        +        SD  ++++E++E L  +++     E+     P      A
Sbjct: 742  ------------EYHTESSRGSDLSDIMEEDEEELYSEMQ----LEDGGRRRPSGTSHNA 785

Query: 1412 LGVKRGCQLHEPSSALCPAPSAKVIKMPRG--GPQ------------------------- 1444
            L +     L  P+SA       +  + PRG  GPQ                         
Sbjct: 786  LKI-----LGNPASAGRVDHMGR--RFPRGSAGPQRSRPVTVPSIDDYGRDRLSPDFYEE 838

Query: 1445 -QLGTGANT-PARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYLSE 1502
             +   GA   PAR+FVAL DY+PL MS N  AAEEEL F++ Q+++V+G +D   FY  E
Sbjct: 839  SETDPGAEELPARIFVALFDYDPLTMSPNPDAAEEELPFKEGQIIKVYGDKDADGFYRGE 898

Query: 1503 CNRQVGNIPGRLVAEMEVGTEQ-TDRRWRSPAQGHLPSVAHLEDFQGLTIPQGSSLVLQG 1561
               ++G IP  +V+E++   E+  D+  R   QG LP    +E  +              
Sbjct: 899  TCARLGLIPCNMVSEIQADDEEMMDQLLR---QGFLPLNTPVEKIE-----------RSR 944

Query: 1562 NSKRLPLWTPKIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGELGG 1621
             S R    + + M+A  DYDP +       +  L    GD++ V+G +D+ GFYYGEL G
Sbjct: 945  RSGRRHSVSTRRMVALYDYDPRESSPNVDVEAELTFCTGDIITVFGEIDEDGFYYGELNG 1004

Query: 1622 HRGLVPAHLLDHM 1634
             +GLVP++ L+ +
Sbjct: 1005 QKGLVPSNFLEEV 1017



 Score = 71.6 bits (174), Expect = 6e-12
 Identities = 35/63 (55%), Positives = 47/63 (74%), Gaps = 2/63 (3%)

Query: 838  MAQYNYNPFEG-PNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELDDGRRGLVPSNFVEQ 896
            +A Y+Y+P E  PN   E EL    GD I +FG++DEDGFY GEL +G++GLVPSNF+E+
Sbjct: 958  VALYDYDPRESSPNVDVEAELTFCTGDIITVFGEIDEDGFYYGEL-NGQKGLVPSNFLEE 1016

Query: 897  IPD 899
            +PD
Sbjct: 1017 VPD 1019


>gi|171906567 peripheral benzodiazepine receptor-associated protein 1
            isoform b [Homo sapiens]
          Length = 1797

 Score =  270 bits (691), Expect = 6e-72
 Identities = 329/1147 (28%), Positives = 472/1147 (41%), Gaps = 278/1147 (24%)

Query: 377  NWLLAKALWVLARRCYTLQEENKQLRRAGCPYQADEKVKRLKVKRAELTGLARRLADRAR 436
            N  L +AL  L +RC  L+EEN+ LR++  P + +EKV+RLK K AEL  +       A+
Sbjct: 123  NLELLRALGELRQRCAILKEENQMLRKSSFP-ETEEKVRRLKRKNAELAVI-------AK 174

Query: 437  ELQETNLRAVSAPIPGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQECHLL 496
             L+E                           RAR L E              LR E    
Sbjct: 175  RLEE---------------------------RARKLQET------------NLRVE---- 191

Query: 497  QARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQ---------- 546
                             GP  QWL+VRD DRL RESQREVLRLQRQ+ L+          
Sbjct: 192  -----------------GP--QWLHVRDFDRLLRESQREVLRLQRQIALRNQRETLPLPP 232

Query: 547  --------QGNGGA-WPEAGGQSATCE------------EVRRQMLALERELDQRRRECQ 585
                    Q   GA  P A G++   E            E  +++  LE EL ++R++C+
Sbjct: 233  SWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCE 292

Query: 586  ELGTQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGR 645
             L  +A   +RR EE E QL+ A  +NA L EEN RL  +     +VE EN+E+RG L  
Sbjct: 293  SLEQEARKKQRRCEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLG 352

Query: 646  ACQERDAS-----GLIA-----EQLLQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQAL 695
              QERD++     GL +     EQ+L+       R+QQL+ + ++A   L    +E++ L
Sbjct: 353  VTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRL 412

Query: 696  QCRPGHPPEQPWETSQMPESQVKGS----RRPKFHARPEDYAVSQPNRDIQEKREASLEE 751
            Q        +     Q+ ES +       R  +   R +    S   +++Q  R   L  
Sbjct: 413  QQAQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFR---LHP 469

Query: 752  SPVALGESA----------------SVPQV-----------------------SETVPAS 772
             P+ L  SA                S+PQ                        SE  PA+
Sbjct: 470  GPLDLLTSALDCGSLGDCPPPPCCCSIPQPCRGSGPKDLDLPPGSPGRCTPKSSEPAPAT 529

Query: 773  -----QPLSKKTSSQSNSSSEGSMWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGSA 827
                 +  +KK  S SNSS   S+  +  S PT + DTASEV++LE DSVSL L      
Sbjct: 530  LTGVPRRTAKKAESLSNSSHSESIHNSPKSCPTPEVDTASEVEELEADSVSL-LPAAPEG 588

Query: 828  APAAPKLKIFMAQYNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELDDGRRG 887
            +    ++++F+A+Y+YNPFEGPN++PE ELPLTAG+YIYI+G+MDEDGF+EGEL DGRRG
Sbjct: 589  SRGGARIQVFLARYSYNPFEGPNENPEAELPLTAGEYIYIYGNMDEDGFFEGELMDGRRG 648

Query: 888  LVPSNFVEQIPDSYIPGCLPAKSPDL---------------------GPSQLPAGQDEAL 926
            LVPSNFVE++ D  +   LP +  DL                     G S +   Q    
Sbjct: 649  LVPSNFVERVSDDDLLTSLPPELADLSHSSGPELSFLSVGGGGSSSGGQSSVGRSQPRPE 708

Query: 927  EEDS----LLSGKAQGMVD-------RGLCQMVRVGSKTEVATEILDTKTE-----ACQL 970
            EED+     LS   +G+ +       R L  + ++     +A E    + E      C  
Sbjct: 709  EEDAGDELSLSPSPEGLGEPPAVPYPRRLVVLKQLAHSVVLAWEPPPEQVELHGFHICVN 768

Query: 971  G-LLQSMGKQGLSRPLLGTKGVLRMAPMQLHLQNVTA--TSANITWVYSSHRHPHVVYLD 1027
            G L Q++G     + +L     L   P+ + +Q +T+  +S  +    +      VV   
Sbjct: 769  GELRQALGPGAPPKAVLENLD-LWAGPLHISVQALTSRGSSDPLRCCLAVGARAGVVPSQ 827

Query: 1028 DREHALTPAGVSCYTFQGLCPGTHYRVRVEVRLPWDLLQVYWGTM---------SSTVTF 1078
             R H LT          G     H         P      YW T           + V  
Sbjct: 828  LRVHRLTATSAEITWVPGNSNLAHAIYLNGEECPPASPSTYWATFCHLRPGTPYQAQVEA 887

Query: 1079 DTLLAGPPYPPLEVLVERHASPGVLVVSWLPVTIDSA--------GSSNGVQVTGY---- 1126
                 GP  P  E L +R A+   L  + LP     A        G S G+ +  +    
Sbjct: 888  QLPPQGPWEPGWERLEQRAAT---LQFTTLPAGPPDAPLDVQIEPGPSPGILIISWLPVT 944

Query: 1127 ---AVYADGLKVCEVADATAGSTVL------------EFSQLQVPLTWQKVSVRTMSLCG 1171
               A  ++G++V   A    G  ++            E SQLQ+    ++V VRTMS  G
Sbjct: 945  IDAAGTSNGVRVTGYAIYADGQKIMEVASPTAGSVLVELSQLQLLQVCREVVVRTMSPHG 1004

Query: 1172 ESLDSVPAQIPEDFFMCHRWPETPPFSYTC--------------------GDPST-YRVT 1210
            ES DS+PA I          P + P   +C                    GDPS+  +  
Sbjct: 1005 ESADSIPAPITPALA-----PASLPARVSCPSPHPSPEARAPLASASPGPGDPSSPLQHP 1059

Query: 1211 FPVCPQKLSLAPPSAKASPHNPGSCGEPQAKFLE-----AFFEEPPRRQSPVSNLGSEGE 1265
             P+  Q+   APP++ +     GS  +P A   +     A       R +  S LG +  
Sbjct: 1060 APLGTQEPPGAPPASPSREMAKGSHEDPPAPCSQEEAGAAVLGTSEERTASTSTLGEKD- 1118

Query: 1266 CPSSGAGSQAQELAE--AWEGCRKDLLFQKSPQNHRPPSVSDQPGEKENCYQHMGTSKSP 1323
             P   A S A++ AE  A E C      Q +     P +   Q G+  +  +     +  
Sbjct: 1119 -PGPAAPSLAKQEAEWTAGEACPASSSTQGARAQQAPNTEMCQGGDPGSGLRPRAEKEDT 1177

Query: 1324 APGFIHL 1330
            A   +HL
Sbjct: 1178 AELGVHL 1184



 Score =  127 bits (319), Expect = 9e-29
 Identities = 97/265 (36%), Positives = 130/265 (49%), Gaps = 37/265 (13%)

Query: 1391 RGTERREERREPEPHSRQGQALGVKRGCQLHEPSSA-LCPAPSAKVIKMPRGGPQQLGTG 1449
            R TE  E R +     R  Q    KRG ++  PS+A L PA S          P +    
Sbjct: 1517 RATETGEARGQDGSGRRGPQ----KRGVRVLRPSTAELVPARS----------PSETLAY 1562

Query: 1450 ANTPARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYLSECNRQVGN 1509
             + P R+FVAL DY+P+ MS N  A EEEL F++ Q+L+V+G +D   FY  E   + G 
Sbjct: 1563 QHLPVRIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRTGY 1622

Query: 1510 IPGRLVAEMEV----GTEQT-DRRWRSP-----AQGHLPSVAHLEDFQG---------LT 1550
            IP  +VAE+ V    G +Q   R + SP       G+ P V       G           
Sbjct: 1623 IPCNMVAEVAVDSPAGRQQLLQRGYLSPDILLEGSGNGPFVYSTAHTTGPPPKPRRSKKA 1682

Query: 1551 IPQGSSLVLQGNSKRLP---LWTPKIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYG 1607
              +G +    G  K +P   L  P  M+AA DY+P +       +  L  RAGDV+ V+G
Sbjct: 1683 ESEGPAQPCPGPPKLVPSADLKAPHSMVAAFDYNPQESSPNMDVEAELPFRAGDVITVFG 1742

Query: 1608 PMDDQGFYYGELGGHRGLVPAHLLD 1632
             MDD GFYYGEL G RGLVP++ L+
Sbjct: 1743 GMDDDGFYYGELNGQRGLVPSNFLE 1767



 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 36/59 (61%), Positives = 44/59 (74%), Gaps = 2/59 (3%)

Query: 838  MAQYNYNPFEG-PNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELDDGRRGLVPSNFVE 895
            +A ++YNP E  PN   E ELP  AGD I +FG MD+DGFY GEL +G+RGLVPSNF+E
Sbjct: 1710 VAAFDYNPQESSPNMDVEAELPFRAGDVITVFGGMDDDGFYYGEL-NGQRGLVPSNFLE 1767



 Score = 58.2 bits (139), Expect = 7e-08
 Identities = 65/219 (29%), Positives = 90/219 (41%), Gaps = 41/219 (18%)

Query: 723  PKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTSSQ 782
            PK ++ P+ Y    P     EK E      P   G SA       T  A +PLS+ T + 
Sbjct: 1480 PKANSGPKPY----PRLPAWEKGE------PERRGRSA-------TGRAKEPLSRATETG 1522

Query: 783  SNSSSEGS-MWATVPSSPTLDRDTASEVDDLEPDSVSLALEMGGSAAPAAPKLKIFMAQY 841
                 +GS           + R + +E+      S +LA +           ++IF+A +
Sbjct: 1523 EARGQDGSGRRGPQKRGVRVLRPSTAELVPARSPSETLAYQH--------LPVRIFVALF 1574

Query: 842  NYNPFE-GPN-DHPEGELPLTAGDYIYIFGDMDEDGFYEGELDDGRRGLVPSNFVEQIPD 899
            +Y+P    PN D  E ELP   G  + +FGD D DGFY+GE   GR G +P N V ++  
Sbjct: 1575 DYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGE-GGGRTGYIPCNMVAEV-- 1631

Query: 900  SYIPGCLPAKSPDLGPSQLPAGQDEALEEDSLLSGKAQG 938
                    A     G  QL   Q   L  D LL G   G
Sbjct: 1632 --------AVDSPAGRQQLL--QRGYLSPDILLEGSGNG 1660



 Score = 48.9 bits (115), Expect = 4e-05
 Identities = 24/65 (36%), Positives = 40/65 (61%), Gaps = 2/65 (3%)

Query: 1572 KIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGEL-GGHRGLVPAHL 1630
            ++ +A   Y+P +G      +  L L AG+ + +YG MD+ GF+ GEL  G RGLVP++ 
Sbjct: 596  QVFLARYSYNPFEGP-NENPEAELPLTAGEYIYIYGNMDEDGFFEGELMDGRRGLVPSNF 654

Query: 1631 LDHMS 1635
            ++ +S
Sbjct: 655  VERVS 659



 Score = 48.1 bits (113), Expect = 7e-05
 Identities = 86/370 (23%), Positives = 141/370 (38%), Gaps = 63/370 (17%)

Query: 6   PSP-LGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARER--QLR 62
           P P L A    P   +P  A  +     L  +  E E E+   + E      R++   L 
Sbjct: 236 PGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKRKKCESLE 295

Query: 63  EEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLH 122
           +EA +++R+  + L  +    ++   R ++E  +    A  ++ + W+ AE R     + 
Sbjct: 296 QEARKKQRR-CEELELQLRQAQNENARLVEENSRLSGRATEKEQVEWENAELRGQLLGVT 354

Query: 123 RERDGVVRQARELQRQL--AEELVN--RGHCSRPGASEVSAAQCRC----------RLQE 168
           +ERD  +R+++ LQ +L   E+++   R    R    EV   Q R           RLQ+
Sbjct: 355 QERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQ 414

Query: 169 VLAQLRWQTDG----------EQAARIRYL--QAALEVERQLFLKYILAHFRGHP----- 211
             A+ + + +G             AR+R L  Q   + E+   L   L  FR HP     
Sbjct: 415 AQAEAQREHEGAVQLLESTLDSMQARVRELEEQCRSQTEQFSLLAQELQAFRLHPGPLDL 474

Query: 212 --------ALSGSPDPQAVHSLEEP----------LPQTSSGSCHAPKPACQLGSLDSLS 253
                   +L   P P    S+ +P          LP  S G C  PK      S  + +
Sbjct: 475 LTSALDCGSLGDCPPPPCCCSIPQPCRGSGPKDLDLPPGSPGRC-TPK-----SSEPAPA 528

Query: 254 AEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPS 313
              GV  R+     S  +SS     S H S   C  P    + +      +A      P+
Sbjct: 529 TLTGVPRRTAKKAESLSNSSHSE--SIHNSPKSCPTPEVDTASEVEEL--EADSVSLLPA 584

Query: 314 SPDTSTPGSR 323
           +P+ S  G+R
Sbjct: 585 APEGSRGGAR 594



 Score = 46.2 bits (108), Expect = 3e-04
 Identities = 22/66 (33%), Positives = 35/66 (53%), Gaps = 1/66 (1%)

Query: 1572 KIMIAALDYDPGDGQMGGQ-GKGRLALRAGDVVMVYGPMDDQGFYYGELGGHRGLVPAHL 1630
            +I +A  DYDP         G+  L  R G ++ V+G  D  GFY GE GG  G +P ++
Sbjct: 1568 RIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRTGYIPCNM 1627

Query: 1631 LDHMSL 1636
            +  +++
Sbjct: 1628 VAEVAV 1633



 Score = 37.4 bits (85), Expect = 0.12
 Identities = 60/258 (23%), Positives = 100/258 (38%), Gaps = 35/258 (13%)

Query: 331 PLPP--PPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHHELIKLNWLLAKALWVLA 388
           PLPP  PP P+   +   P  G   E+ P E     P  LG  E  +    L   L    
Sbjct: 229 PLPPSWPPGPALQARAGAPAPGAPGEATPQEDADNLPVILGEPEKEQRVQQLESELSKKR 288

Query: 389 RRCYTLQEENKQLRRAGCPYQADEKVKRLKVKRAELTGLARRLADRARELQETNLRAVSA 448
           ++C +L++E ++ +R  C  + + ++++ + + A L     RL+ RA E ++      +A
Sbjct: 289 KKCESLEQEARKKQRR-CE-ELELQLRQAQNENARLVEENSRLSGRATEKEQVEWE--NA 344

Query: 449 PIPGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPCSDL 508
            + G+   G+   +  A ++++ L  +  +     K + E+ Q    L+        S  
Sbjct: 345 ELRGQ-LLGVTQERDSALRKSQGLQSKLESLEQVLKHMREVAQRRQQLEVEHEQARLS-- 401

Query: 509 HTGRGGPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRR 568
                                RE Q EV R      LQQ    A  E  G     E    
Sbjct: 402 --------------------LREKQEEVRR------LQQAQAEAQREHEGAVQLLESTLD 435

Query: 569 QMLALERELDQRRRECQE 586
            M A  REL+++ R   E
Sbjct: 436 SMQARVRELEEQCRSQTE 453


>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 2 [Homo sapiens]
          Length = 1320

 Score = 79.0 bits (193), Expect = 4e-14
 Identities = 92/327 (28%), Positives = 144/327 (44%), Gaps = 35/327 (10%)

Query: 30  RRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELR 89
           RR+  +L+ E   ER+   A RR+   +E+QLRE+ E +R+ LA+  R K   Q+  + R
Sbjct: 353 RRDFLRLQQE-NKERS--EALRRQQLLQEQQLREQEEYKRQLLAE--RQKRIEQQKEQRR 407

Query: 90  QLQEEMQREREA---EIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAE---EL 143
           +L+E+ +REREA   + R+  R ++ E+R+L++L  R ++   R+  E +++  E   E 
Sbjct: 408 RLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEY 467

Query: 144 VNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQLFLKYI 203
           + R         EV   Q   + Q +L + RW+ + E+  +   LQ  L+ E+   L   
Sbjct: 468 IRRQLEEEQRHLEVLQQQL-LQEQAMLLECRWR-EMEEHRQAERLQRQLQQEQAYLLSLQ 525

Query: 204 LAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVRSRSL 263
             H R HP  S  P P        P  + S  S HAP+P       D  + EV  R R  
Sbjct: 526 HDHRRPHPQHSQQPPP--------PQQERSKPSFHAPEPKAHYEPADR-AREVEDRFRKT 576

Query: 264 GLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSPDTSTPGSR 323
                   SSP+         L+   P+ S S  +  S      + +RP+ P        
Sbjct: 577 N------HSSPEAQSKQTGRVLEPPVPSRSESFSNGNS-ESVHPALQRPAEPQVQWSHLA 629

Query: 324 RLSPPPSPL------PPPPPPSAHRKL 344
            L    SP+        P P  AH  L
Sbjct: 630 SLKNNVSPVSRSHSFSDPSPKFAHHHL 656



 Score = 55.1 bits (131), Expect = 6e-07
 Identities = 45/116 (38%), Positives = 62/116 (53%), Gaps = 9/116 (7%)

Query: 27  ENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSR 86
           E QRRE E  R +   +R   + E+RR    ER+ +EE ER R   A+  + + E ++  
Sbjct: 411 EQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRR---AEEEKRRVEREQEY 467

Query: 87  ELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEE 142
             RQL+EE QR  E   +QLL+    EQ  L +   RE +   RQA  LQRQL +E
Sbjct: 468 IRRQLEEE-QRHLEVLQQQLLQ----EQAMLLECRWREME-EHRQAERLQRQLQQE 517



 Score = 52.0 bits (123), Expect = 5e-06
 Identities = 77/297 (25%), Positives = 126/297 (42%), Gaps = 72/297 (24%)

Query: 523 RDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLA---------- 572
           RD  RLQ+E++     L+RQ +LQ+           Q    EE +RQ+LA          
Sbjct: 354 RDFLRLQQENKERSEALRRQQLLQEQ----------QLREQEEYKRQLLAERQKRIEQQK 403

Query: 573 -----------------LERELDQRRRECQELGTQAAPARRRGEEAETQLQAALLKNAWL 615
                             ++E +QRRRE +E        +RR EE E + +         
Sbjct: 404 EQRRRLEEQQRREREARRQQEREQRRREQEE--------KRRLEELERRRK--------- 446

Query: 616 AEENGRLQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQLLQ-QAARGQDRQQQL 674
            EE  R +A+ +  R+VE E   +R  L    +E+    ++ +QLLQ QA   + R +++
Sbjct: 447 -EEEERRRAEEE-KRRVEREQEYIRRQLE---EEQRHLEVLQQQLLQEQAMLLECRWREM 501

Query: 675 QRDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKGSRRPKFHARPEDYAV 734
           +   Q          ++   L  +  H    P  + Q P  Q + S +P FHA PE  A 
Sbjct: 502 EEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPPPPQQERS-KPSFHA-PEPKAH 559

Query: 735 SQP---NRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTSSQSNSSSE 788
            +P    R+++++   +   SP A  +S    +V E      P+  ++ S SN +SE
Sbjct: 560 YEPADRAREVEDRFRKTNHSSPEA--QSKQTGRVLE-----PPVPSRSESFSNGNSE 609


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 203/881 (23%), Positives = 333/881 (37%), Gaps = 164/881 (18%)

Query: 25   VLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQ------------- 71
            V+  Q    E+ R   E E    RA      A++RQ +EEAER RRQ             
Sbjct: 1456 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1515

Query: 72   -LADRLRSKWEAQRSR--------ELR-QLQEEMQREREAEI---RQLLRWKEAEQRQLQ 118
             LA R++++ EA R +        ELR Q +E  +R R+AE+   RQ+    E  QR  +
Sbjct: 1516 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1575

Query: 119  QLLHRERDGVVRQARELQRQLAEELVN----RGHCSRPGASEVSAAQCRCRLQEVLAQLR 174
              L  +R     +  +L+R L EE V     R    R    +  A + R   +  L   R
Sbjct: 1576 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE--R 1633

Query: 175  WQTDGEQAARIRYLQAALEVERQLFLKYILAHFRGHPA-----LSGSPDPQAVHSLE--- 226
            WQ    +A R+R LQA  EV +Q  L    A  +   A       G  + QAV   E   
Sbjct: 1634 WQLKANEALRLR-LQAE-EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1691

Query: 227  ---EPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVRSRSL------GLVSSACSSSP--- 274
               E   Q + G+      A Q         E G + R L       L   A +++    
Sbjct: 1692 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1751

Query: 275  --DGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSPDTSTPGSRRLSPPPSPL 332
              +  L+   + ++    + +R+ + +RS  + SK        +      R L+   + L
Sbjct: 1752 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR-----LEAEAGRFRELAEEAARL 1806

Query: 333  PPPPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHHELIKLNWLLA-KALWVLARRC 391
                  +  ++           ++   VL      +G    +K    +A K       R 
Sbjct: 1807 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1866

Query: 392  YTLQE----ENKQLRRAGCPYQADEKVKRLKVKRAELTGLARR---LADRARELQETNLR 444
              L E    + ++L      ++AD + +  ++++A  + L R+   + D  R+ ++    
Sbjct: 1867 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1926

Query: 445  AVSAPIPGESCAG----LELCQVFARQRARDL---SEQASAPLAKDKQI----EELRQEC 493
             ++     E  A     LEL     R  A D     EQA    A+ +Q+    E  R+E 
Sbjct: 1927 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1986

Query: 494  HLLQARVASGPCSDLHTGRGGPCTQWLNVRDLDRL-------QRESQREVLRLQRQLMLQ 546
               + RV     ++    R         + +++RL       +R  +R      RQL L 
Sbjct: 1987 ---EERVQKSLAAEEEAARQRKAA----LEEVERLKAKVEEARRLRERAEQESARQLQLA 2039

Query: 547  QGNGGAWPEAGGQSATCEE------VRRQMLALERELDQRRRECQELGTQAAPARRRGEE 600
            Q       EA  +    EE      V+++   L++ L Q +    +L  +A  ARR  EE
Sbjct: 2040 Q-------EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2092

Query: 601  AE--------------------------TQLQAALLKNAWLAEENGRLQAKTDWVRKVEA 634
            AE                           + QA     A  A E  R +A+ +  R+ +A
Sbjct: 2093 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2152

Query: 635  ENSEVRGHLGRACQERDASGLIAEQLLQQAARGQD-----RQQQLQRDPQKALCDLHPSW 689
            E + +R     A  E +     AEQ L+Q A+ +      R Q  + D QK L D     
Sbjct: 2153 EQAALR-QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD----- 2206

Query: 690  KEIQALQCRPGHPPEQPWETSQMPES------QVKGSRRPKFHARPEDYAVSQPNRD--- 740
            +E+Q L+       E   + SQ+ E       Q++   + K     E+ A+   ++D   
Sbjct: 2207 EELQRLK---AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2263

Query: 741  --IQEKREASLEES------PVALGESASVPQVSETVPASQ 773
              +QE+ E   + +       VA  E+A + Q++E   A Q
Sbjct: 2264 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2304



 Score = 57.8 bits (138), Expect = 9e-08
 Identities = 177/803 (22%), Positives = 310/803 (38%), Gaps = 77/803 (9%)

Query: 34   EKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELRQLQE 93
            E LR   E ER    AE++R   RER    EA  E+++      ++ +AQ  RE ++LQ+
Sbjct: 1339 ETLRRMEEEERL---AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1395

Query: 94   EMQRE---RE---AEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQR---QLAEE-- 142
             MQ E   RE    + +Q  R  + E +QL+Q    E     RQA   +R   ++ EE  
Sbjct: 1396 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1455

Query: 143  ---LVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQLF 199
               L       + G +E      R R +E  AQ R     E+A R+R  Q   E +R+  
Sbjct: 1456 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ--EEAERLR-RQVQDESQRKRQ 1512

Query: 200  LKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVR 259
             +  LA      A +     +A+ +LEE   Q         +   +      ++ E   R
Sbjct: 1513 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1572

Query: 260  SRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSP---- 315
            S    L S   S +        +   +  A A  R     R+  +A     R  +     
Sbjct: 1573 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1632

Query: 316  ----DTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHH 371
                  +     RL             +   K       E       E        L   
Sbjct: 1633 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1692

Query: 372  ELIKLNWL--------LAKALWVLARRCYTLQ-EENKQL---------RRAGCPYQADEK 413
            EL K   L        LA    ++  R  T Q E+ +QL         R A    Q  ++
Sbjct: 1693 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1752

Query: 414  VK-RLKVKRAELTGLARRLADRARELQETNLRAVSAPIPGESCAG--LELCQVFARQRAR 470
            ++  L   RAE+  L   LA +AR  +E+   +  +    E+ AG   EL +  AR RA 
Sbjct: 1753 LEAELAKVRAEMEVL---LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1809

Query: 471  DLSEQASAPLAKDKQIEELRQECHLLQARVAS-GPCSDLHTGRGGPCTQWLNVRDLDRLQ 529
                +    LA++    +  +   +L  ++A+ G  + L T       +     + +RL+
Sbjct: 1810 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE--KEAENERLR 1867

Query: 530  RESQREVLRLQRQLMLQQGNGGAWPE---AGGQSATCEEVRRQMLALERELDQRRRECQE 586
            R ++ E  + +R+L  Q     A  E   A  + A+  E+ RQ   +E  L QRR+  +E
Sbjct: 1868 RLAEDEAFQ-RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1926

Query: 587  -LGTQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGR 645
             L  +A+  +    +AE +L+   +++        + QA+ +  R+ +    E R    R
Sbjct: 1927 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR--R 1984

Query: 646  ACQERDASGLIAEQLLQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQ 705
              +ER    L AE+  + A + +   ++++R        L    +E + L+ R      +
Sbjct: 1985 EAEERVQKSLAAEE--EAARQRKAALEEVER--------LKAKVEEARRLRER-----AE 2029

Query: 706  PWETSQMPESQVKGSRRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQV 765
                 Q+  +Q    +R +   +   +AV Q  +++Q+  +          GE+ +  + 
Sbjct: 2030 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2089

Query: 766  SETVPASQPLSKKTSSQSNSSSE 788
            +E    ++  +++ ++QS    E
Sbjct: 2090 AEEAEEARVQAEREAAQSRRQVE 2112



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 59/188 (31%), Positives = 89/188 (47%), Gaps = 24/188 (12%)

Query: 23   AAVLENQRRELE-KLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWE 81
            AA  E +RRE E +++  L AE     A R+R AA E   R +A+ E    A RLR + E
Sbjct: 1976 AAEEERRRREAEERVQKSLAAEE---EAARQRKAALEEVERLKAKVEE---ARRLRERAE 2029

Query: 82   AQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGV--VRQARELQRQL 139
             + +R+L+  QE  Q+  +AE +      + ++++LQQ L +E+  +  +R   E  R+ 
Sbjct: 2030 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2089

Query: 140  AEELVN-RGHCSRPGA--------------SEVSAAQCRCRLQEVLAQLRWQTDGEQAAR 184
            AEE    R    R  A              S    AQ R + Q    +LR + + E A R
Sbjct: 2090 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2149

Query: 185  IRYLQAAL 192
             +  QAAL
Sbjct: 2150 AQAEQAAL 2157



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 52/191 (27%), Positives = 96/191 (50%), Gaps = 23/191 (12%)

Query: 24   AVLENQRRELEKLR-AELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEA 82
            +VL+  R E E  R A  EAE A  +AER   AA+ R+  EEAER ++   ++ +++ +A
Sbjct: 2074 SVLDQLRGEAEAARRAAEEAEEARVQAERE--AAQSRRQVEEAERLKQSAEEQAQARAQA 2131

Query: 83   QRSRELRQLQEEMQREREAEIRQ-LLRWKEAEQRQLQQLLHRE-RDGVVRQARELQRQLA 140
            Q + E  + + E +  R A+  Q  LR K+A   ++++  H++  +  +RQ  +++++L 
Sbjct: 2132 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK--HKKFAEQTLRQKAQVEQELT 2189

Query: 141  E---ELVNRGH--------CSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQ 189
                +L    H          R  A    AA+ R +++E L  +R Q +      +  L+
Sbjct: 2190 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME-----ELSKLK 2244

Query: 190  AALEVERQLFL 200
            A +E E +  +
Sbjct: 2245 ARIEAENRALI 2255



 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 56/186 (30%), Positives = 89/186 (47%), Gaps = 20/186 (10%)

Query: 29   QRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSREL 88
            Q  EL KL+A +EAE        +     +R L+EEAE+ ++   +  R    AQ +  L
Sbjct: 2236 QMEELSKLKARIEAENRALILRDKDNT--QRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2293

Query: 89   RQLQEEMQREREAEIRQLLRWK-----EAEQRQLQ-QLLHRERDGVVRQARELQ------ 136
            RQL EE   ++ A   ++L+ K     EA + + + +LL ++++    QAR LQ      
Sbjct: 2294 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2353

Query: 137  -RQLAEE---LVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAAL 192
             +QLAEE           R    E+SA   R +L+ V    R Q   E+ A+ R+ + A 
Sbjct: 2354 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR-VAEMSRAQARAEEDAQ-RFRKQAE 2411

Query: 193  EVERQL 198
            E+  +L
Sbjct: 2412 EIGEKL 2417



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 56/204 (27%), Positives = 81/204 (39%), Gaps = 46/204 (22%)

Query: 24   AVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQ 83
            A L+ +     + R ELEAE A  RAE     A     +  AE E R  +++ + + EA+
Sbjct: 1737 ARLQREAAAATQKRQELEAELAKVRAEMEVLLAS----KARAEEESRSTSEKSKQRLEAE 1792

Query: 84   RSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEEL 143
              R  R+L EE  R R       L  +   QRQL +      +   RQ  E +R LAE+L
Sbjct: 1793 AGR-FRELAEEAARLR------ALAEEAKRQRQLAE------EDAARQRAEAERVLAEKL 1839

Query: 144  VNRGHCSRPGAS-----------------------------EVSAAQCRCRLQEVLAQLR 174
               G  +R                                 E  AAQ +  ++E LAQLR
Sbjct: 1840 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1899

Query: 175  WQTDGEQAARIRYLQAALEVERQL 198
              +D E   +   ++  L   RQ+
Sbjct: 1900 KASDSELERQKGLVEDTLRQRRQV 1923



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 58/189 (30%), Positives = 90/189 (47%), Gaps = 36/189 (19%)

Query: 32   ELEKLRAEL-EAERAGWRAERRRFAARER-----QLREEAERERRQLADRLRSKWEAQR- 84
            EL++L+AE  EA R   + E   F+ R +     +L+   E E R L   LR K   QR 
Sbjct: 2208 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI--LRDKDNTQRF 2265

Query: 85   ----SRELRQLQEEMQR-----EREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQAREL 135
                + +++Q+ EE  R     +  A +RQL     A+QR L + + +E+   V++A  L
Sbjct: 2266 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2325

Query: 136  QRQLAEELVNRGHCSRPGASEVSAAQCRCRLQE----VLAQLRWQTDGEQ----AARIRY 187
            + +   EL+ +         E++  Q R RLQE    +  QL  +T G Q    A R R 
Sbjct: 2326 KAE--AELLQQ-------QKELAQEQAR-RLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2375

Query: 188  LQAALEVER 196
            L+ + E ER
Sbjct: 2376 LEMSAEAER 2384



 Score = 44.7 bits (104), Expect = 8e-04
 Identities = 33/122 (27%), Positives = 67/122 (54%), Gaps = 11/122 (9%)

Query: 40   LEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQRER 99
            +E E+A      +   A+ +QLREE +R+++Q+        E +R R +  ++E  +R+ 
Sbjct: 2509 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM--------EQERQRLVASMEEARRRQH 2560

Query: 100  EAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSA 159
            EAE  + +R K+ E +QL+Q   ++ + +  + + L+ QL + L  +   +   + EV+A
Sbjct: 2561 EAE--EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL-QLLEEQHRAALAHSEEVTA 2617

Query: 160  AQ 161
            +Q
Sbjct: 2618 SQ 2619



 Score = 41.2 bits (95), Expect = 0.008
 Identities = 34/125 (27%), Positives = 61/125 (48%), Gaps = 20/125 (16%)

Query: 30   RRELEKLRAELEAERAGWRAERRRFAARER------------QLREEAERERRQLADRLR 77
            R E +  R   +AE  G +  R   A +E+            Q   +AER R  +A+  R
Sbjct: 2398 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2457

Query: 78   SKWEAQRSRELRQLQ-EEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQ 136
             K + Q+  +L QL+ EEMQ  ++ ++ Q       E + LQQ    E+D ++++ R ++
Sbjct: 2458 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQ-------ETQALQQSFLSEKDSLLQRERFIE 2510

Query: 137  RQLAE 141
            ++ A+
Sbjct: 2511 QEKAK 2515



 Score = 40.8 bits (94), Expect = 0.011
 Identities = 88/420 (20%), Positives = 163/420 (38%), Gaps = 63/420 (15%)

Query: 375  KLNWLLAKALWVLARRCYTLQEENK--QLRRAGCPYQADEKVKRLKVKRAELTGLARRLA 432
            +L  L ++ +  ++     ++EE +  + +RA    +  E    L+ +R      A+  A
Sbjct: 1325 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1384

Query: 433  DRARELQETNLRAVSAPIPGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQE 492
               RE +E   R     +  E  A      V A+Q+ R + E+          +++LRQ 
Sbjct: 1385 QAEREAKELQQRMQEEVVRREEAA------VDAQQQKRSIQEE----------LQQLRQS 1428

Query: 493  CHL-LQARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQQGNGG 551
                +QA+      ++                   RL+ E +  V+RLQ +   +Q  GG
Sbjct: 1429 SEAEIQAKARQAEAAER-----------------SRLRIEEEIRVVRLQLEATERQ-RGG 1470

Query: 552  AWPEAGGQSATCEEVRRQMLALERELDQRRRECQELGTQAAPARRRGEEAETQLQAALLK 611
            A  E     A  EE   Q    + E ++ RR+ Q+         +R  +AE +L + +  
Sbjct: 1471 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD-------ESQRKRQAEVELASRVKA 1523

Query: 612  NAWLAEENGR-LQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQLLQQAARGQ-- 668
             A  A E  R LQA  +   +++AE +E R  L +A  ER     +A +  Q++A  +  
Sbjct: 1524 EAEAAREKQRALQALEE--LRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQ 1579

Query: 669  -------DRQQQLQRDPQK---ALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVK 718
                   ++  QL+R  Q+   A+  L    +     Q       E+     ++   Q+K
Sbjct: 1580 SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE--AERELERWQLK 1637

Query: 719  GSRRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKK 778
             +   +   + E+ A  +     + +++    E        A    V +   A Q L K+
Sbjct: 1638 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1697



 Score = 40.4 bits (93), Expect = 0.014
 Identities = 40/140 (28%), Positives = 65/140 (46%), Gaps = 20/140 (14%)

Query: 26   LENQRRELEKLRAELEAERAGWRAER----------RRFAARERQLREEAERERRQLADR 75
            LE  +  L+KLRA+ EA++  + A R           R   R  +   E ER R ++A +
Sbjct: 1125 LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA-Q 1183

Query: 76   LRSKWEA------QRSRELRQLQEEMQREREA--EIRQLLRWKEAEQRQLQQLLHRERDG 127
            L  +W+A       R REL QL  +++  RE+   +   L+     Q Q+Q +   +   
Sbjct: 1184 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1243

Query: 128  VVRQARELQRQLAEELVNRG 147
            V  Q R+ ++ L EE+   G
Sbjct: 1244 VREQLRQ-EQALLEEIERHG 1262



 Score = 39.7 bits (91), Expect = 0.024
 Identities = 42/174 (24%), Positives = 72/174 (41%), Gaps = 7/174 (4%)

Query: 24   AVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQ 83
            A +E  R+    L     +  A  +++R  FA +  QL    + E   +A +LR   EA+
Sbjct: 1555 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA-QLRE--EAE 1611

Query: 84   RSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEEL 143
            R     Q Q E +R RE   R+L RW+      L+  L  E     +   + + +  +E 
Sbjct: 1612 RRA---QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1668

Query: 144  VNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQ 197
              R    R G +E  A + R   ++ L + R   +G    R+   Q  + +  +
Sbjct: 1669 AER-EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE 1721



 Score = 39.7 bits (91), Expect = 0.024
 Identities = 53/186 (28%), Positives = 84/186 (45%), Gaps = 16/186 (8%)

Query: 23   AAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWE- 81
            AA L    +E  +LR   E + A  RA   +    + Q  +EA R + + A+ L+ + E 
Sbjct: 2280 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE-AELLQQQKEL 2338

Query: 82   -AQRSRELRQLQEEMQREREAEIRQLLRWKEAE-QRQLQQLLHRERDGVVRQARELQRQL 139
              +++R L++ +E+M ++   E +   R  EAE QRQL+     ER  +        +  
Sbjct: 2339 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2398

Query: 140  AEELVNRGHCSRPGASEVS--------AAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAA 191
            AEE   R    R  A E+         A Q +  L + L   R Q+D   A R+R   A 
Sbjct: 2399 AEEDAQR---FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD-HDAERLREAIAE 2454

Query: 192  LEVERQ 197
            LE E++
Sbjct: 2455 LEREKE 2460



 Score = 38.5 bits (88), Expect = 0.054
 Identities = 35/136 (25%), Positives = 67/136 (49%), Gaps = 20/136 (14%)

Query: 26   LENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRS 85
            +E ++ +LE+L  +  A+    R E++R   +++Q+ +E +R    + +  R + EA   
Sbjct: 2509 IEQEKAKLEQLFQDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEA--- 2562

Query: 86   RELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVN 145
                   EE  R ++ E++QL    E ++RQ ++LL  E   +  Q + L+ Q    L  
Sbjct: 2563 -------EEGVRRKQEELQQL----EQQRRQQEELLAEENQRLREQLQLLEEQHRAAL-- 2609

Query: 146  RGHCSRPGASEVSAAQ 161
              H     AS+V+A +
Sbjct: 2610 -AHSEEVTASQVAATK 2624



 Score = 37.7 bits (86), Expect = 0.092
 Identities = 38/136 (27%), Positives = 71/136 (52%), Gaps = 16/136 (11%)

Query: 26   LENQRRE----LEKLR---AELEAERAGWRAERRRFAARERQLR----EEAERERRQLAD 74
            LE QR++     E+LR   AELE E+   + E +    +  +++    E+  +E + L  
Sbjct: 2434 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2493

Query: 75   RLRSKWEA--QRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQA 132
               S+ ++  QR R + Q + ++++  + E+ +  + +E +QRQ QQ + +ER  +V   
Sbjct: 2494 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASM 2552

Query: 133  RELQRQL--AEELVNR 146
             E +R+   AEE V R
Sbjct: 2553 EEARRRQHEAEEGVRR 2568



 Score = 36.6 bits (83), Expect = 0.21
 Identities = 55/186 (29%), Positives = 82/186 (44%), Gaps = 23/186 (12%)

Query: 23   AAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERE--RRQLADR--LRS 78
            AA    Q  E E+L+   E E+A  RA+ +   A   +LR+EAE+E  RR  A++  LR 
Sbjct: 2104 AAQSRRQVEEAERLKQSAE-EQAQARAQAQ---AAAEKLRKEAEQEAARRAQAEQAALRQ 2159

Query: 79   KWEAQRSRELRQLQEEMQREREAEIRQ---LLRWKEAEQRQLQQLLHRERDGVVRQAREL 135
            K  A    E  +   E    ++A++ Q    LR +  E    + LL  E   +  +A E 
Sbjct: 2160 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2219

Query: 136  QR---QLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAAL 192
             R   Q+ EEL +     R    E+S  + R   +     LR   D  Q    R+LQ   
Sbjct: 2220 ARQRSQVEEELFS----VRVQMEELSKLKARIEAENRALILR-DKDNTQ----RFLQEEA 2270

Query: 193  EVERQL 198
            E  +Q+
Sbjct: 2271 EKMKQV 2276



 Score = 36.6 bits (83), Expect = 0.21
 Identities = 54/231 (23%), Positives = 100/231 (43%), Gaps = 36/231 (15%)

Query: 413  KVKRLKVKRAELTGL-------ARRLADRARELQETNLRAVSAPIPGESCAGLELCQVFA 465
            + +RLK++ AE++         A+R   +A E+ E   R   A    E    ++  ++  
Sbjct: 2381 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT--QEKVTLVQTLEIQR 2438

Query: 466  RQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPCSDLHTGRGGPCTQWLNVRDL 525
            +Q   D      A    +++ E+L+QE  LLQ +       ++ T +     Q   +++ 
Sbjct: 2439 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLK-----SEEMQTVQ-----QEQLLQET 2488

Query: 526  DRLQRE--SQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRRE 583
              LQ+   S+++ L LQR+  ++Q           + A  +++R +    +++++Q R  
Sbjct: 2489 QALQQSFLSEKDSL-LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER-- 2545

Query: 584  CQELGTQAAPARRRGEEAETQL-----------QAALLKNAWLAEENGRLQ 623
             Q L      ARRR  EAE  +           Q    +   LAEEN RL+
Sbjct: 2546 -QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2595



 Score = 33.1 bits (74), Expect = 2.3
 Identities = 34/121 (28%), Positives = 52/121 (42%), Gaps = 12/121 (9%)

Query: 22   AAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLR------EEAERERRQLADR 75
            A  + E Q+R+ +++  E +   A     RRR    E  +R      ++ E++RRQ  + 
Sbjct: 2527 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2586

Query: 76   LRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQAREL 135
            L    E QR RE  QL EE  R   A   ++     A Q    + L   RD +   A E 
Sbjct: 2587 LAE--ENQRLREQLQLLEEQHRAALAHSEEV----TASQVAATKTLPNGRDALDGPAAEA 2640

Query: 136  Q 136
            +
Sbjct: 2641 E 2641


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 203/881 (23%), Positives = 333/881 (37%), Gaps = 164/881 (18%)

Query: 25   VLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQ------------- 71
            V+  Q    E+ R   E E    RA      A++RQ +EEAER RRQ             
Sbjct: 1460 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1519

Query: 72   -LADRLRSKWEAQRSR--------ELR-QLQEEMQREREAEI---RQLLRWKEAEQRQLQ 118
             LA R++++ EA R +        ELR Q +E  +R R+AE+   RQ+    E  QR  +
Sbjct: 1520 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1579

Query: 119  QLLHRERDGVVRQARELQRQLAEELVN----RGHCSRPGASEVSAAQCRCRLQEVLAQLR 174
              L  +R     +  +L+R L EE V     R    R    +  A + R   +  L   R
Sbjct: 1580 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE--R 1637

Query: 175  WQTDGEQAARIRYLQAALEVERQLFLKYILAHFRGHPA-----LSGSPDPQAVHSLE--- 226
            WQ    +A R+R LQA  EV +Q  L    A  +   A       G  + QAV   E   
Sbjct: 1638 WQLKANEALRLR-LQAE-EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1695

Query: 227  ---EPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVRSRSL------GLVSSACSSSP--- 274
               E   Q + G+      A Q         E G + R L       L   A +++    
Sbjct: 1696 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1755

Query: 275  --DGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSPDTSTPGSRRLSPPPSPL 332
              +  L+   + ++    + +R+ + +RS  + SK        +      R L+   + L
Sbjct: 1756 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR-----LEAEAGRFRELAEEAARL 1810

Query: 333  PPPPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHHELIKLNWLLA-KALWVLARRC 391
                  +  ++           ++   VL      +G    +K    +A K       R 
Sbjct: 1811 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1870

Query: 392  YTLQE----ENKQLRRAGCPYQADEKVKRLKVKRAELTGLARR---LADRARELQETNLR 444
              L E    + ++L      ++AD + +  ++++A  + L R+   + D  R+ ++    
Sbjct: 1871 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1930

Query: 445  AVSAPIPGESCAG----LELCQVFARQRARDL---SEQASAPLAKDKQI----EELRQEC 493
             ++     E  A     LEL     R  A D     EQA    A+ +Q+    E  R+E 
Sbjct: 1931 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1990

Query: 494  HLLQARVASGPCSDLHTGRGGPCTQWLNVRDLDRL-------QRESQREVLRLQRQLMLQ 546
               + RV     ++    R         + +++RL       +R  +R      RQL L 
Sbjct: 1991 ---EERVQKSLAAEEEAARQRKAA----LEEVERLKAKVEEARRLRERAEQESARQLQLA 2043

Query: 547  QGNGGAWPEAGGQSATCEE------VRRQMLALERELDQRRRECQELGTQAAPARRRGEE 600
            Q       EA  +    EE      V+++   L++ L Q +    +L  +A  ARR  EE
Sbjct: 2044 Q-------EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2096

Query: 601  AE--------------------------TQLQAALLKNAWLAEENGRLQAKTDWVRKVEA 634
            AE                           + QA     A  A E  R +A+ +  R+ +A
Sbjct: 2097 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2156

Query: 635  ENSEVRGHLGRACQERDASGLIAEQLLQQAARGQD-----RQQQLQRDPQKALCDLHPSW 689
            E + +R     A  E +     AEQ L+Q A+ +      R Q  + D QK L D     
Sbjct: 2157 EQAALR-QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD----- 2210

Query: 690  KEIQALQCRPGHPPEQPWETSQMPES------QVKGSRRPKFHARPEDYAVSQPNRD--- 740
            +E+Q L+       E   + SQ+ E       Q++   + K     E+ A+   ++D   
Sbjct: 2211 EELQRLK---AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2267

Query: 741  --IQEKREASLEES------PVALGESASVPQVSETVPASQ 773
              +QE+ E   + +       VA  E+A + Q++E   A Q
Sbjct: 2268 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2308



 Score = 57.8 bits (138), Expect = 9e-08
 Identities = 177/803 (22%), Positives = 310/803 (38%), Gaps = 77/803 (9%)

Query: 34   EKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELRQLQE 93
            E LR   E ER    AE++R   RER    EA  E+++      ++ +AQ  RE ++LQ+
Sbjct: 1343 ETLRRMEEEERL---AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1399

Query: 94   EMQRE---RE---AEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQR---QLAEE-- 142
             MQ E   RE    + +Q  R  + E +QL+Q    E     RQA   +R   ++ EE  
Sbjct: 1400 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1459

Query: 143  ---LVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQLF 199
               L       + G +E      R R +E  AQ R     E+A R+R  Q   E +R+  
Sbjct: 1460 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ--EEAERLR-RQVQDESQRKRQ 1516

Query: 200  LKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVR 259
             +  LA      A +     +A+ +LEE   Q         +   +      ++ E   R
Sbjct: 1517 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1576

Query: 260  SRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSP---- 315
            S    L S   S +        +   +  A A  R     R+  +A     R  +     
Sbjct: 1577 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1636

Query: 316  ----DTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHH 371
                  +     RL             +   K       E       E        L   
Sbjct: 1637 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1696

Query: 372  ELIKLNWL--------LAKALWVLARRCYTLQ-EENKQL---------RRAGCPYQADEK 413
            EL K   L        LA    ++  R  T Q E+ +QL         R A    Q  ++
Sbjct: 1697 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1756

Query: 414  VK-RLKVKRAELTGLARRLADRARELQETNLRAVSAPIPGESCAG--LELCQVFARQRAR 470
            ++  L   RAE+  L   LA +AR  +E+   +  +    E+ AG   EL +  AR RA 
Sbjct: 1757 LEAELAKVRAEMEVL---LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1813

Query: 471  DLSEQASAPLAKDKQIEELRQECHLLQARVAS-GPCSDLHTGRGGPCTQWLNVRDLDRLQ 529
                +    LA++    +  +   +L  ++A+ G  + L T       +     + +RL+
Sbjct: 1814 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE--KEAENERLR 1871

Query: 530  RESQREVLRLQRQLMLQQGNGGAWPE---AGGQSATCEEVRRQMLALERELDQRRRECQE 586
            R ++ E  + +R+L  Q     A  E   A  + A+  E+ RQ   +E  L QRR+  +E
Sbjct: 1872 RLAEDEAFQ-RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1930

Query: 587  -LGTQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGR 645
             L  +A+  +    +AE +L+   +++        + QA+ +  R+ +    E R    R
Sbjct: 1931 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR--R 1988

Query: 646  ACQERDASGLIAEQLLQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQ 705
              +ER    L AE+  + A + +   ++++R        L    +E + L+ R      +
Sbjct: 1989 EAEERVQKSLAAEE--EAARQRKAALEEVER--------LKAKVEEARRLRER-----AE 2033

Query: 706  PWETSQMPESQVKGSRRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQV 765
                 Q+  +Q    +R +   +   +AV Q  +++Q+  +          GE+ +  + 
Sbjct: 2034 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2093

Query: 766  SETVPASQPLSKKTSSQSNSSSE 788
            +E    ++  +++ ++QS    E
Sbjct: 2094 AEEAEEARVQAEREAAQSRRQVE 2116



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 59/188 (31%), Positives = 89/188 (47%), Gaps = 24/188 (12%)

Query: 23   AAVLENQRRELE-KLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWE 81
            AA  E +RRE E +++  L AE     A R+R AA E   R +A+ E    A RLR + E
Sbjct: 1980 AAEEERRRREAEERVQKSLAAEE---EAARQRKAALEEVERLKAKVEE---ARRLRERAE 2033

Query: 82   AQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGV--VRQARELQRQL 139
             + +R+L+  QE  Q+  +AE +      + ++++LQQ L +E+  +  +R   E  R+ 
Sbjct: 2034 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2093

Query: 140  AEELVN-RGHCSRPGA--------------SEVSAAQCRCRLQEVLAQLRWQTDGEQAAR 184
            AEE    R    R  A              S    AQ R + Q    +LR + + E A R
Sbjct: 2094 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2153

Query: 185  IRYLQAAL 192
             +  QAAL
Sbjct: 2154 AQAEQAAL 2161



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 52/191 (27%), Positives = 96/191 (50%), Gaps = 23/191 (12%)

Query: 24   AVLENQRRELEKLR-AELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEA 82
            +VL+  R E E  R A  EAE A  +AER   AA+ R+  EEAER ++   ++ +++ +A
Sbjct: 2078 SVLDQLRGEAEAARRAAEEAEEARVQAERE--AAQSRRQVEEAERLKQSAEEQAQARAQA 2135

Query: 83   QRSRELRQLQEEMQREREAEIRQ-LLRWKEAEQRQLQQLLHRE-RDGVVRQARELQRQLA 140
            Q + E  + + E +  R A+  Q  LR K+A   ++++  H++  +  +RQ  +++++L 
Sbjct: 2136 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK--HKKFAEQTLRQKAQVEQELT 2193

Query: 141  E---ELVNRGH--------CSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQ 189
                +L    H          R  A    AA+ R +++E L  +R Q +      +  L+
Sbjct: 2194 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME-----ELSKLK 2248

Query: 190  AALEVERQLFL 200
            A +E E +  +
Sbjct: 2249 ARIEAENRALI 2259



 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 56/186 (30%), Positives = 89/186 (47%), Gaps = 20/186 (10%)

Query: 29   QRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSREL 88
            Q  EL KL+A +EAE        +     +R L+EEAE+ ++   +  R    AQ +  L
Sbjct: 2240 QMEELSKLKARIEAENRALILRDKDNT--QRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2297

Query: 89   RQLQEEMQREREAEIRQLLRWK-----EAEQRQLQ-QLLHRERDGVVRQARELQ------ 136
            RQL EE   ++ A   ++L+ K     EA + + + +LL ++++    QAR LQ      
Sbjct: 2298 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2357

Query: 137  -RQLAEE---LVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAAL 192
             +QLAEE           R    E+SA   R +L+ V    R Q   E+ A+ R+ + A 
Sbjct: 2358 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR-VAEMSRAQARAEEDAQ-RFRKQAE 2415

Query: 193  EVERQL 198
            E+  +L
Sbjct: 2416 EIGEKL 2421



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 56/204 (27%), Positives = 81/204 (39%), Gaps = 46/204 (22%)

Query: 24   AVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQ 83
            A L+ +     + R ELEAE A  RAE     A     +  AE E R  +++ + + EA+
Sbjct: 1741 ARLQREAAAATQKRQELEAELAKVRAEMEVLLAS----KARAEEESRSTSEKSKQRLEAE 1796

Query: 84   RSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEEL 143
              R  R+L EE  R R       L  +   QRQL +      +   RQ  E +R LAE+L
Sbjct: 1797 AGR-FRELAEEAARLR------ALAEEAKRQRQLAE------EDAARQRAEAERVLAEKL 1843

Query: 144  VNRGHCSRPGAS-----------------------------EVSAAQCRCRLQEVLAQLR 174
               G  +R                                 E  AAQ +  ++E LAQLR
Sbjct: 1844 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1903

Query: 175  WQTDGEQAARIRYLQAALEVERQL 198
              +D E   +   ++  L   RQ+
Sbjct: 1904 KASDSELERQKGLVEDTLRQRRQV 1927



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 58/189 (30%), Positives = 90/189 (47%), Gaps = 36/189 (19%)

Query: 32   ELEKLRAEL-EAERAGWRAERRRFAARER-----QLREEAERERRQLADRLRSKWEAQR- 84
            EL++L+AE  EA R   + E   F+ R +     +L+   E E R L   LR K   QR 
Sbjct: 2212 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI--LRDKDNTQRF 2269

Query: 85   ----SRELRQLQEEMQR-----EREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQAREL 135
                + +++Q+ EE  R     +  A +RQL     A+QR L + + +E+   V++A  L
Sbjct: 2270 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2329

Query: 136  QRQLAEELVNRGHCSRPGASEVSAAQCRCRLQE----VLAQLRWQTDGEQ----AARIRY 187
            + +   EL+ +         E++  Q R RLQE    +  QL  +T G Q    A R R 
Sbjct: 2330 KAE--AELLQQ-------QKELAQEQAR-RLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2379

Query: 188  LQAALEVER 196
            L+ + E ER
Sbjct: 2380 LEMSAEAER 2388



 Score = 44.7 bits (104), Expect = 8e-04
 Identities = 33/122 (27%), Positives = 67/122 (54%), Gaps = 11/122 (9%)

Query: 40   LEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQRER 99
            +E E+A      +   A+ +QLREE +R+++Q+        E +R R +  ++E  +R+ 
Sbjct: 2513 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM--------EQERQRLVASMEEARRRQH 2564

Query: 100  EAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSA 159
            EAE  + +R K+ E +QL+Q   ++ + +  + + L+ QL + L  +   +   + EV+A
Sbjct: 2565 EAE--EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL-QLLEEQHRAALAHSEEVTA 2621

Query: 160  AQ 161
            +Q
Sbjct: 2622 SQ 2623



 Score = 41.2 bits (95), Expect = 0.008
 Identities = 34/125 (27%), Positives = 61/125 (48%), Gaps = 20/125 (16%)

Query: 30   RRELEKLRAELEAERAGWRAERRRFAARER------------QLREEAERERRQLADRLR 77
            R E +  R   +AE  G +  R   A +E+            Q   +AER R  +A+  R
Sbjct: 2402 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2461

Query: 78   SKWEAQRSRELRQLQ-EEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQ 136
             K + Q+  +L QL+ EEMQ  ++ ++ Q       E + LQQ    E+D ++++ R ++
Sbjct: 2462 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQ-------ETQALQQSFLSEKDSLLQRERFIE 2514

Query: 137  RQLAE 141
            ++ A+
Sbjct: 2515 QEKAK 2519



 Score = 40.8 bits (94), Expect = 0.011
 Identities = 88/420 (20%), Positives = 163/420 (38%), Gaps = 63/420 (15%)

Query: 375  KLNWLLAKALWVLARRCYTLQEENK--QLRRAGCPYQADEKVKRLKVKRAELTGLARRLA 432
            +L  L ++ +  ++     ++EE +  + +RA    +  E    L+ +R      A+  A
Sbjct: 1329 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1388

Query: 433  DRARELQETNLRAVSAPIPGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQE 492
               RE +E   R     +  E  A      V A+Q+ R + E+          +++LRQ 
Sbjct: 1389 QAEREAKELQQRMQEEVVRREEAA------VDAQQQKRSIQEE----------LQQLRQS 1432

Query: 493  CHL-LQARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQQGNGG 551
                +QA+      ++                   RL+ E +  V+RLQ +   +Q  GG
Sbjct: 1433 SEAEIQAKARQAEAAER-----------------SRLRIEEEIRVVRLQLEATERQ-RGG 1474

Query: 552  AWPEAGGQSATCEEVRRQMLALERELDQRRRECQELGTQAAPARRRGEEAETQLQAALLK 611
            A  E     A  EE   Q    + E ++ RR+ Q+         +R  +AE +L + +  
Sbjct: 1475 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD-------ESQRKRQAEVELASRVKA 1527

Query: 612  NAWLAEENGR-LQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQLLQQAARGQ-- 668
             A  A E  R LQA  +   +++AE +E R  L +A  ER     +A +  Q++A  +  
Sbjct: 1528 EAEAAREKQRALQALEE--LRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQ 1583

Query: 669  -------DRQQQLQRDPQK---ALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVK 718
                   ++  QL+R  Q+   A+  L    +     Q       E+     ++   Q+K
Sbjct: 1584 SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE--AERELERWQLK 1641

Query: 719  GSRRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKK 778
             +   +   + E+ A  +     + +++    E        A    V +   A Q L K+
Sbjct: 1642 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1701



 Score = 40.4 bits (93), Expect = 0.014
 Identities = 40/140 (28%), Positives = 65/140 (46%), Gaps = 20/140 (14%)

Query: 26   LENQRRELEKLRAELEAERAGWRAER----------RRFAARERQLREEAERERRQLADR 75
            LE  +  L+KLRA+ EA++  + A R           R   R  +   E ER R ++A +
Sbjct: 1129 LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA-Q 1187

Query: 76   LRSKWEA------QRSRELRQLQEEMQREREA--EIRQLLRWKEAEQRQLQQLLHRERDG 127
            L  +W+A       R REL QL  +++  RE+   +   L+     Q Q+Q +   +   
Sbjct: 1188 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1247

Query: 128  VVRQARELQRQLAEELVNRG 147
            V  Q R+ ++ L EE+   G
Sbjct: 1248 VREQLRQ-EQALLEEIERHG 1266



 Score = 39.7 bits (91), Expect = 0.024
 Identities = 42/174 (24%), Positives = 72/174 (41%), Gaps = 7/174 (4%)

Query: 24   AVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQ 83
            A +E  R+    L     +  A  +++R  FA +  QL    + E   +A +LR   EA+
Sbjct: 1559 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA-QLRE--EAE 1615

Query: 84   RSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEEL 143
            R     Q Q E +R RE   R+L RW+      L+  L  E     +   + + +  +E 
Sbjct: 1616 RRA---QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1672

Query: 144  VNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQ 197
              R    R G +E  A + R   ++ L + R   +G    R+   Q  + +  +
Sbjct: 1673 AER-EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE 1725



 Score = 39.7 bits (91), Expect = 0.024
 Identities = 53/186 (28%), Positives = 84/186 (45%), Gaps = 16/186 (8%)

Query: 23   AAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWE- 81
            AA L    +E  +LR   E + A  RA   +    + Q  +EA R + + A+ L+ + E 
Sbjct: 2284 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE-AELLQQQKEL 2342

Query: 82   -AQRSRELRQLQEEMQREREAEIRQLLRWKEAE-QRQLQQLLHRERDGVVRQARELQRQL 139
              +++R L++ +E+M ++   E +   R  EAE QRQL+     ER  +        +  
Sbjct: 2343 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2402

Query: 140  AEELVNRGHCSRPGASEVS--------AAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAA 191
            AEE   R    R  A E+         A Q +  L + L   R Q+D   A R+R   A 
Sbjct: 2403 AEEDAQR---FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD-HDAERLREAIAE 2458

Query: 192  LEVERQ 197
            LE E++
Sbjct: 2459 LEREKE 2464



 Score = 38.5 bits (88), Expect = 0.054
 Identities = 35/136 (25%), Positives = 67/136 (49%), Gaps = 20/136 (14%)

Query: 26   LENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRS 85
            +E ++ +LE+L  +  A+    R E++R   +++Q+ +E +R    + +  R + EA   
Sbjct: 2513 IEQEKAKLEQLFQDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEA--- 2566

Query: 86   RELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVN 145
                   EE  R ++ E++QL    E ++RQ ++LL  E   +  Q + L+ Q    L  
Sbjct: 2567 -------EEGVRRKQEELQQL----EQQRRQQEELLAEENQRLREQLQLLEEQHRAAL-- 2613

Query: 146  RGHCSRPGASEVSAAQ 161
              H     AS+V+A +
Sbjct: 2614 -AHSEEVTASQVAATK 2628



 Score = 37.7 bits (86), Expect = 0.092
 Identities = 38/136 (27%), Positives = 71/136 (52%), Gaps = 16/136 (11%)

Query: 26   LENQRRE----LEKLR---AELEAERAGWRAERRRFAARERQLR----EEAERERRQLAD 74
            LE QR++     E+LR   AELE E+   + E +    +  +++    E+  +E + L  
Sbjct: 2438 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2497

Query: 75   RLRSKWEA--QRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQA 132
               S+ ++  QR R + Q + ++++  + E+ +  + +E +QRQ QQ + +ER  +V   
Sbjct: 2498 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASM 2556

Query: 133  RELQRQL--AEELVNR 146
             E +R+   AEE V R
Sbjct: 2557 EEARRRQHEAEEGVRR 2572



 Score = 36.6 bits (83), Expect = 0.21
 Identities = 55/186 (29%), Positives = 82/186 (44%), Gaps = 23/186 (12%)

Query: 23   AAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERE--RRQLADR--LRS 78
            AA    Q  E E+L+   E E+A  RA+ +   A   +LR+EAE+E  RR  A++  LR 
Sbjct: 2108 AAQSRRQVEEAERLKQSAE-EQAQARAQAQ---AAAEKLRKEAEQEAARRAQAEQAALRQ 2163

Query: 79   KWEAQRSRELRQLQEEMQREREAEIRQ---LLRWKEAEQRQLQQLLHRERDGVVRQAREL 135
            K  A    E  +   E    ++A++ Q    LR +  E    + LL  E   +  +A E 
Sbjct: 2164 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2223

Query: 136  QR---QLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAAL 192
             R   Q+ EEL +     R    E+S  + R   +     LR   D  Q    R+LQ   
Sbjct: 2224 ARQRSQVEEELFS----VRVQMEELSKLKARIEAENRALILR-DKDNTQ----RFLQEEA 2274

Query: 193  EVERQL 198
            E  +Q+
Sbjct: 2275 EKMKQV 2280



 Score = 36.6 bits (83), Expect = 0.21
 Identities = 54/231 (23%), Positives = 100/231 (43%), Gaps = 36/231 (15%)

Query: 413  KVKRLKVKRAELTGL-------ARRLADRARELQETNLRAVSAPIPGESCAGLELCQVFA 465
            + +RLK++ AE++         A+R   +A E+ E   R   A    E    ++  ++  
Sbjct: 2385 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT--QEKVTLVQTLEIQR 2442

Query: 466  RQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPCSDLHTGRGGPCTQWLNVRDL 525
            +Q   D      A    +++ E+L+QE  LLQ +       ++ T +     Q   +++ 
Sbjct: 2443 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLK-----SEEMQTVQ-----QEQLLQET 2492

Query: 526  DRLQRE--SQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRRE 583
              LQ+   S+++ L LQR+  ++Q           + A  +++R +    +++++Q R  
Sbjct: 2493 QALQQSFLSEKDSL-LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER-- 2549

Query: 584  CQELGTQAAPARRRGEEAETQL-----------QAALLKNAWLAEENGRLQ 623
             Q L      ARRR  EAE  +           Q    +   LAEEN RL+
Sbjct: 2550 -QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2599



 Score = 33.1 bits (74), Expect = 2.3
 Identities = 34/121 (28%), Positives = 52/121 (42%), Gaps = 12/121 (9%)

Query: 22   AAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLR------EEAERERRQLADR 75
            A  + E Q+R+ +++  E +   A     RRR    E  +R      ++ E++RRQ  + 
Sbjct: 2531 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2590

Query: 76   LRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQAREL 135
            L    E QR RE  QL EE  R   A   ++     A Q    + L   RD +   A E 
Sbjct: 2591 LAE--ENQRLREQLQLLEEQHRAALAHSEEV----TASQVAATKTLPNGRDALDGPAAEA 2644

Query: 136  Q 136
            +
Sbjct: 2645 E 2645


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 203/881 (23%), Positives = 333/881 (37%), Gaps = 164/881 (18%)

Query: 25   VLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQ------------- 71
            V+  Q    E+ R   E E    RA      A++RQ +EEAER RRQ             
Sbjct: 1456 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1515

Query: 72   -LADRLRSKWEAQRSR--------ELR-QLQEEMQREREAEI---RQLLRWKEAEQRQLQ 118
             LA R++++ EA R +        ELR Q +E  +R R+AE+   RQ+    E  QR  +
Sbjct: 1516 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1575

Query: 119  QLLHRERDGVVRQARELQRQLAEELVN----RGHCSRPGASEVSAAQCRCRLQEVLAQLR 174
              L  +R     +  +L+R L EE V     R    R    +  A + R   +  L   R
Sbjct: 1576 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE--R 1633

Query: 175  WQTDGEQAARIRYLQAALEVERQLFLKYILAHFRGHPA-----LSGSPDPQAVHSLE--- 226
            WQ    +A R+R LQA  EV +Q  L    A  +   A       G  + QAV   E   
Sbjct: 1634 WQLKANEALRLR-LQAE-EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1691

Query: 227  ---EPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVRSRSL------GLVSSACSSSP--- 274
               E   Q + G+      A Q         E G + R L       L   A +++    
Sbjct: 1692 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1751

Query: 275  --DGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSPDTSTPGSRRLSPPPSPL 332
              +  L+   + ++    + +R+ + +RS  + SK        +      R L+   + L
Sbjct: 1752 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR-----LEAEAGRFRELAEEAARL 1806

Query: 333  PPPPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHHELIKLNWLLA-KALWVLARRC 391
                  +  ++           ++   VL      +G    +K    +A K       R 
Sbjct: 1807 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1866

Query: 392  YTLQE----ENKQLRRAGCPYQADEKVKRLKVKRAELTGLARR---LADRARELQETNLR 444
              L E    + ++L      ++AD + +  ++++A  + L R+   + D  R+ ++    
Sbjct: 1867 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1926

Query: 445  AVSAPIPGESCAG----LELCQVFARQRARDL---SEQASAPLAKDKQI----EELRQEC 493
             ++     E  A     LEL     R  A D     EQA    A+ +Q+    E  R+E 
Sbjct: 1927 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1986

Query: 494  HLLQARVASGPCSDLHTGRGGPCTQWLNVRDLDRL-------QRESQREVLRLQRQLMLQ 546
               + RV     ++    R         + +++RL       +R  +R      RQL L 
Sbjct: 1987 ---EERVQKSLAAEEEAARQRKAA----LEEVERLKAKVEEARRLRERAEQESARQLQLA 2039

Query: 547  QGNGGAWPEAGGQSATCEE------VRRQMLALERELDQRRRECQELGTQAAPARRRGEE 600
            Q       EA  +    EE      V+++   L++ L Q +    +L  +A  ARR  EE
Sbjct: 2040 Q-------EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2092

Query: 601  AE--------------------------TQLQAALLKNAWLAEENGRLQAKTDWVRKVEA 634
            AE                           + QA     A  A E  R +A+ +  R+ +A
Sbjct: 2093 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2152

Query: 635  ENSEVRGHLGRACQERDASGLIAEQLLQQAARGQD-----RQQQLQRDPQKALCDLHPSW 689
            E + +R     A  E +     AEQ L+Q A+ +      R Q  + D QK L D     
Sbjct: 2153 EQAALR-QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD----- 2206

Query: 690  KEIQALQCRPGHPPEQPWETSQMPES------QVKGSRRPKFHARPEDYAVSQPNRD--- 740
            +E+Q L+       E   + SQ+ E       Q++   + K     E+ A+   ++D   
Sbjct: 2207 EELQRLK---AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2263

Query: 741  --IQEKREASLEES------PVALGESASVPQVSETVPASQ 773
              +QE+ E   + +       VA  E+A + Q++E   A Q
Sbjct: 2264 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2304



 Score = 57.8 bits (138), Expect = 9e-08
 Identities = 177/803 (22%), Positives = 310/803 (38%), Gaps = 77/803 (9%)

Query: 34   EKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELRQLQE 93
            E LR   E ER    AE++R   RER    EA  E+++      ++ +AQ  RE ++LQ+
Sbjct: 1339 ETLRRMEEEERL---AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1395

Query: 94   EMQRE---RE---AEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQR---QLAEE-- 142
             MQ E   RE    + +Q  R  + E +QL+Q    E     RQA   +R   ++ EE  
Sbjct: 1396 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1455

Query: 143  ---LVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQLF 199
               L       + G +E      R R +E  AQ R     E+A R+R  Q   E +R+  
Sbjct: 1456 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ--EEAERLR-RQVQDESQRKRQ 1512

Query: 200  LKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVR 259
             +  LA      A +     +A+ +LEE   Q         +   +      ++ E   R
Sbjct: 1513 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1572

Query: 260  SRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSP---- 315
            S    L S   S +        +   +  A A  R     R+  +A     R  +     
Sbjct: 1573 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1632

Query: 316  ----DTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHH 371
                  +     RL             +   K       E       E        L   
Sbjct: 1633 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1692

Query: 372  ELIKLNWL--------LAKALWVLARRCYTLQ-EENKQL---------RRAGCPYQADEK 413
            EL K   L        LA    ++  R  T Q E+ +QL         R A    Q  ++
Sbjct: 1693 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1752

Query: 414  VK-RLKVKRAELTGLARRLADRARELQETNLRAVSAPIPGESCAG--LELCQVFARQRAR 470
            ++  L   RAE+  L   LA +AR  +E+   +  +    E+ AG   EL +  AR RA 
Sbjct: 1753 LEAELAKVRAEMEVL---LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1809

Query: 471  DLSEQASAPLAKDKQIEELRQECHLLQARVAS-GPCSDLHTGRGGPCTQWLNVRDLDRLQ 529
                +    LA++    +  +   +L  ++A+ G  + L T       +     + +RL+
Sbjct: 1810 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE--KEAENERLR 1867

Query: 530  RESQREVLRLQRQLMLQQGNGGAWPE---AGGQSATCEEVRRQMLALERELDQRRRECQE 586
            R ++ E  + +R+L  Q     A  E   A  + A+  E+ RQ   +E  L QRR+  +E
Sbjct: 1868 RLAEDEAFQ-RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1926

Query: 587  -LGTQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGR 645
             L  +A+  +    +AE +L+   +++        + QA+ +  R+ +    E R    R
Sbjct: 1927 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR--R 1984

Query: 646  ACQERDASGLIAEQLLQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQ 705
              +ER    L AE+  + A + +   ++++R        L    +E + L+ R      +
Sbjct: 1985 EAEERVQKSLAAEE--EAARQRKAALEEVER--------LKAKVEEARRLRER-----AE 2029

Query: 706  PWETSQMPESQVKGSRRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQV 765
                 Q+  +Q    +R +   +   +AV Q  +++Q+  +          GE+ +  + 
Sbjct: 2030 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2089

Query: 766  SETVPASQPLSKKTSSQSNSSSE 788
            +E    ++  +++ ++QS    E
Sbjct: 2090 AEEAEEARVQAEREAAQSRRQVE 2112



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 59/188 (31%), Positives = 89/188 (47%), Gaps = 24/188 (12%)

Query: 23   AAVLENQRRELE-KLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWE 81
            AA  E +RRE E +++  L AE     A R+R AA E   R +A+ E    A RLR + E
Sbjct: 1976 AAEEERRRREAEERVQKSLAAEE---EAARQRKAALEEVERLKAKVEE---ARRLRERAE 2029

Query: 82   AQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGV--VRQARELQRQL 139
             + +R+L+  QE  Q+  +AE +      + ++++LQQ L +E+  +  +R   E  R+ 
Sbjct: 2030 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2089

Query: 140  AEELVN-RGHCSRPGA--------------SEVSAAQCRCRLQEVLAQLRWQTDGEQAAR 184
            AEE    R    R  A              S    AQ R + Q    +LR + + E A R
Sbjct: 2090 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2149

Query: 185  IRYLQAAL 192
             +  QAAL
Sbjct: 2150 AQAEQAAL 2157



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 52/191 (27%), Positives = 96/191 (50%), Gaps = 23/191 (12%)

Query: 24   AVLENQRRELEKLR-AELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEA 82
            +VL+  R E E  R A  EAE A  +AER   AA+ R+  EEAER ++   ++ +++ +A
Sbjct: 2074 SVLDQLRGEAEAARRAAEEAEEARVQAERE--AAQSRRQVEEAERLKQSAEEQAQARAQA 2131

Query: 83   QRSRELRQLQEEMQREREAEIRQ-LLRWKEAEQRQLQQLLHRE-RDGVVRQARELQRQLA 140
            Q + E  + + E +  R A+  Q  LR K+A   ++++  H++  +  +RQ  +++++L 
Sbjct: 2132 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK--HKKFAEQTLRQKAQVEQELT 2189

Query: 141  E---ELVNRGH--------CSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQ 189
                +L    H          R  A    AA+ R +++E L  +R Q +      +  L+
Sbjct: 2190 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME-----ELSKLK 2244

Query: 190  AALEVERQLFL 200
            A +E E +  +
Sbjct: 2245 ARIEAENRALI 2255



 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 56/186 (30%), Positives = 89/186 (47%), Gaps = 20/186 (10%)

Query: 29   QRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSREL 88
            Q  EL KL+A +EAE        +     +R L+EEAE+ ++   +  R    AQ +  L
Sbjct: 2236 QMEELSKLKARIEAENRALILRDKDNT--QRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2293

Query: 89   RQLQEEMQREREAEIRQLLRWK-----EAEQRQLQ-QLLHRERDGVVRQARELQ------ 136
            RQL EE   ++ A   ++L+ K     EA + + + +LL ++++    QAR LQ      
Sbjct: 2294 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2353

Query: 137  -RQLAEE---LVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAAL 192
             +QLAEE           R    E+SA   R +L+ V    R Q   E+ A+ R+ + A 
Sbjct: 2354 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR-VAEMSRAQARAEEDAQ-RFRKQAE 2411

Query: 193  EVERQL 198
            E+  +L
Sbjct: 2412 EIGEKL 2417



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 56/204 (27%), Positives = 81/204 (39%), Gaps = 46/204 (22%)

Query: 24   AVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQ 83
            A L+ +     + R ELEAE A  RAE     A     +  AE E R  +++ + + EA+
Sbjct: 1737 ARLQREAAAATQKRQELEAELAKVRAEMEVLLAS----KARAEEESRSTSEKSKQRLEAE 1792

Query: 84   RSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEEL 143
              R  R+L EE  R R       L  +   QRQL +      +   RQ  E +R LAE+L
Sbjct: 1793 AGR-FRELAEEAARLR------ALAEEAKRQRQLAE------EDAARQRAEAERVLAEKL 1839

Query: 144  VNRGHCSRPGAS-----------------------------EVSAAQCRCRLQEVLAQLR 174
               G  +R                                 E  AAQ +  ++E LAQLR
Sbjct: 1840 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1899

Query: 175  WQTDGEQAARIRYLQAALEVERQL 198
              +D E   +   ++  L   RQ+
Sbjct: 1900 KASDSELERQKGLVEDTLRQRRQV 1923



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 58/189 (30%), Positives = 90/189 (47%), Gaps = 36/189 (19%)

Query: 32   ELEKLRAEL-EAERAGWRAERRRFAARER-----QLREEAERERRQLADRLRSKWEAQR- 84
            EL++L+AE  EA R   + E   F+ R +     +L+   E E R L   LR K   QR 
Sbjct: 2208 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI--LRDKDNTQRF 2265

Query: 85   ----SRELRQLQEEMQR-----EREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQAREL 135
                + +++Q+ EE  R     +  A +RQL     A+QR L + + +E+   V++A  L
Sbjct: 2266 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2325

Query: 136  QRQLAEELVNRGHCSRPGASEVSAAQCRCRLQE----VLAQLRWQTDGEQ----AARIRY 187
            + +   EL+ +         E++  Q R RLQE    +  QL  +T G Q    A R R 
Sbjct: 2326 KAE--AELLQQ-------QKELAQEQAR-RLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2375

Query: 188  LQAALEVER 196
            L+ + E ER
Sbjct: 2376 LEMSAEAER 2384



 Score = 44.7 bits (104), Expect = 8e-04
 Identities = 33/122 (27%), Positives = 67/122 (54%), Gaps = 11/122 (9%)

Query: 40   LEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQRER 99
            +E E+A      +   A+ +QLREE +R+++Q+        E +R R +  ++E  +R+ 
Sbjct: 2509 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM--------EQERQRLVASMEEARRRQH 2560

Query: 100  EAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSA 159
            EAE  + +R K+ E +QL+Q   ++ + +  + + L+ QL + L  +   +   + EV+A
Sbjct: 2561 EAE--EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL-QLLEEQHRAALAHSEEVTA 2617

Query: 160  AQ 161
            +Q
Sbjct: 2618 SQ 2619



 Score = 41.2 bits (95), Expect = 0.008
 Identities = 34/125 (27%), Positives = 61/125 (48%), Gaps = 20/125 (16%)

Query: 30   RRELEKLRAELEAERAGWRAERRRFAARER------------QLREEAERERRQLADRLR 77
            R E +  R   +AE  G +  R   A +E+            Q   +AER R  +A+  R
Sbjct: 2398 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2457

Query: 78   SKWEAQRSRELRQLQ-EEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQ 136
             K + Q+  +L QL+ EEMQ  ++ ++ Q       E + LQQ    E+D ++++ R ++
Sbjct: 2458 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQ-------ETQALQQSFLSEKDSLLQRERFIE 2510

Query: 137  RQLAE 141
            ++ A+
Sbjct: 2511 QEKAK 2515



 Score = 40.8 bits (94), Expect = 0.011
 Identities = 88/420 (20%), Positives = 163/420 (38%), Gaps = 63/420 (15%)

Query: 375  KLNWLLAKALWVLARRCYTLQEENK--QLRRAGCPYQADEKVKRLKVKRAELTGLARRLA 432
            +L  L ++ +  ++     ++EE +  + +RA    +  E    L+ +R      A+  A
Sbjct: 1325 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1384

Query: 433  DRARELQETNLRAVSAPIPGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQE 492
               RE +E   R     +  E  A      V A+Q+ R + E+          +++LRQ 
Sbjct: 1385 QAEREAKELQQRMQEEVVRREEAA------VDAQQQKRSIQEE----------LQQLRQS 1428

Query: 493  CHL-LQARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQQGNGG 551
                +QA+      ++                   RL+ E +  V+RLQ +   +Q  GG
Sbjct: 1429 SEAEIQAKARQAEAAER-----------------SRLRIEEEIRVVRLQLEATERQ-RGG 1470

Query: 552  AWPEAGGQSATCEEVRRQMLALERELDQRRRECQELGTQAAPARRRGEEAETQLQAALLK 611
            A  E     A  EE   Q    + E ++ RR+ Q+         +R  +AE +L + +  
Sbjct: 1471 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD-------ESQRKRQAEVELASRVKA 1523

Query: 612  NAWLAEENGR-LQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQLLQQAARGQ-- 668
             A  A E  R LQA  +   +++AE +E R  L +A  ER     +A +  Q++A  +  
Sbjct: 1524 EAEAAREKQRALQALEE--LRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQ 1579

Query: 669  -------DRQQQLQRDPQK---ALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVK 718
                   ++  QL+R  Q+   A+  L    +     Q       E+     ++   Q+K
Sbjct: 1580 SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE--AERELERWQLK 1637

Query: 719  GSRRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKK 778
             +   +   + E+ A  +     + +++    E        A    V +   A Q L K+
Sbjct: 1638 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1697



 Score = 40.4 bits (93), Expect = 0.014
 Identities = 40/140 (28%), Positives = 65/140 (46%), Gaps = 20/140 (14%)

Query: 26   LENQRRELEKLRAELEAERAGWRAER----------RRFAARERQLREEAERERRQLADR 75
            LE  +  L+KLRA+ EA++  + A R           R   R  +   E ER R ++A +
Sbjct: 1125 LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA-Q 1183

Query: 76   LRSKWEA------QRSRELRQLQEEMQREREA--EIRQLLRWKEAEQRQLQQLLHRERDG 127
            L  +W+A       R REL QL  +++  RE+   +   L+     Q Q+Q +   +   
Sbjct: 1184 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1243

Query: 128  VVRQARELQRQLAEELVNRG 147
            V  Q R+ ++ L EE+   G
Sbjct: 1244 VREQLRQ-EQALLEEIERHG 1262



 Score = 39.7 bits (91), Expect = 0.024
 Identities = 42/174 (24%), Positives = 72/174 (41%), Gaps = 7/174 (4%)

Query: 24   AVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQ 83
            A +E  R+    L     +  A  +++R  FA +  QL    + E   +A +LR   EA+
Sbjct: 1555 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA-QLRE--EAE 1611

Query: 84   RSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEEL 143
            R     Q Q E +R RE   R+L RW+      L+  L  E     +   + + +  +E 
Sbjct: 1612 RRA---QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1668

Query: 144  VNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQ 197
              R    R G +E  A + R   ++ L + R   +G    R+   Q  + +  +
Sbjct: 1669 AER-EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE 1721



 Score = 39.7 bits (91), Expect = 0.024
 Identities = 53/186 (28%), Positives = 84/186 (45%), Gaps = 16/186 (8%)

Query: 23   AAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWE- 81
            AA L    +E  +LR   E + A  RA   +    + Q  +EA R + + A+ L+ + E 
Sbjct: 2280 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE-AELLQQQKEL 2338

Query: 82   -AQRSRELRQLQEEMQREREAEIRQLLRWKEAE-QRQLQQLLHRERDGVVRQARELQRQL 139
              +++R L++ +E+M ++   E +   R  EAE QRQL+     ER  +        +  
Sbjct: 2339 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2398

Query: 140  AEELVNRGHCSRPGASEVS--------AAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAA 191
            AEE   R    R  A E+         A Q +  L + L   R Q+D   A R+R   A 
Sbjct: 2399 AEEDAQR---FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD-HDAERLREAIAE 2454

Query: 192  LEVERQ 197
            LE E++
Sbjct: 2455 LEREKE 2460



 Score = 38.5 bits (88), Expect = 0.054
 Identities = 35/136 (25%), Positives = 67/136 (49%), Gaps = 20/136 (14%)

Query: 26   LENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRS 85
            +E ++ +LE+L  +  A+    R E++R   +++Q+ +E +R    + +  R + EA   
Sbjct: 2509 IEQEKAKLEQLFQDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEA--- 2562

Query: 86   RELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVN 145
                   EE  R ++ E++QL    E ++RQ ++LL  E   +  Q + L+ Q    L  
Sbjct: 2563 -------EEGVRRKQEELQQL----EQQRRQQEELLAEENQRLREQLQLLEEQHRAAL-- 2609

Query: 146  RGHCSRPGASEVSAAQ 161
              H     AS+V+A +
Sbjct: 2610 -AHSEEVTASQVAATK 2624



 Score = 37.7 bits (86), Expect = 0.092
 Identities = 38/136 (27%), Positives = 71/136 (52%), Gaps = 16/136 (11%)

Query: 26   LENQRRE----LEKLR---AELEAERAGWRAERRRFAARERQLR----EEAERERRQLAD 74
            LE QR++     E+LR   AELE E+   + E +    +  +++    E+  +E + L  
Sbjct: 2434 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2493

Query: 75   RLRSKWEA--QRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQA 132
               S+ ++  QR R + Q + ++++  + E+ +  + +E +QRQ QQ + +ER  +V   
Sbjct: 2494 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASM 2552

Query: 133  RELQRQL--AEELVNR 146
             E +R+   AEE V R
Sbjct: 2553 EEARRRQHEAEEGVRR 2568



 Score = 36.6 bits (83), Expect = 0.21
 Identities = 55/186 (29%), Positives = 82/186 (44%), Gaps = 23/186 (12%)

Query: 23   AAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERE--RRQLADR--LRS 78
            AA    Q  E E+L+   E E+A  RA+ +   A   +LR+EAE+E  RR  A++  LR 
Sbjct: 2104 AAQSRRQVEEAERLKQSAE-EQAQARAQAQ---AAAEKLRKEAEQEAARRAQAEQAALRQ 2159

Query: 79   KWEAQRSRELRQLQEEMQREREAEIRQ---LLRWKEAEQRQLQQLLHRERDGVVRQAREL 135
            K  A    E  +   E    ++A++ Q    LR +  E    + LL  E   +  +A E 
Sbjct: 2160 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2219

Query: 136  QR---QLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAAL 192
             R   Q+ EEL +     R    E+S  + R   +     LR   D  Q    R+LQ   
Sbjct: 2220 ARQRSQVEEELFS----VRVQMEELSKLKARIEAENRALILR-DKDNTQ----RFLQEEA 2270

Query: 193  EVERQL 198
            E  +Q+
Sbjct: 2271 EKMKQV 2276



 Score = 36.6 bits (83), Expect = 0.21
 Identities = 54/231 (23%), Positives = 100/231 (43%), Gaps = 36/231 (15%)

Query: 413  KVKRLKVKRAELTGL-------ARRLADRARELQETNLRAVSAPIPGESCAGLELCQVFA 465
            + +RLK++ AE++         A+R   +A E+ E   R   A    E    ++  ++  
Sbjct: 2381 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT--QEKVTLVQTLEIQR 2438

Query: 466  RQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPCSDLHTGRGGPCTQWLNVRDL 525
            +Q   D      A    +++ E+L+QE  LLQ +       ++ T +     Q   +++ 
Sbjct: 2439 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLK-----SEEMQTVQ-----QEQLLQET 2488

Query: 526  DRLQRE--SQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRRE 583
              LQ+   S+++ L LQR+  ++Q           + A  +++R +    +++++Q R  
Sbjct: 2489 QALQQSFLSEKDSL-LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER-- 2545

Query: 584  CQELGTQAAPARRRGEEAETQL-----------QAALLKNAWLAEENGRLQ 623
             Q L      ARRR  EAE  +           Q    +   LAEEN RL+
Sbjct: 2546 -QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2595



 Score = 33.1 bits (74), Expect = 2.3
 Identities = 34/121 (28%), Positives = 52/121 (42%), Gaps = 12/121 (9%)

Query: 22   AAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLR------EEAERERRQLADR 75
            A  + E Q+R+ +++  E +   A     RRR    E  +R      ++ E++RRQ  + 
Sbjct: 2527 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2586

Query: 76   LRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQAREL 135
            L    E QR RE  QL EE  R   A   ++     A Q    + L   RD +   A E 
Sbjct: 2587 LAE--ENQRLREQLQLLEEQHRAALAHSEEV----TASQVAATKTLPNGRDALDGPAAEA 2640

Query: 136  Q 136
            +
Sbjct: 2641 E 2641


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 203/881 (23%), Positives = 333/881 (37%), Gaps = 164/881 (18%)

Query: 25   VLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQ------------- 71
            V+  Q    E+ R   E E    RA      A++RQ +EEAER RRQ             
Sbjct: 1424 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1483

Query: 72   -LADRLRSKWEAQRSR--------ELR-QLQEEMQREREAEI---RQLLRWKEAEQRQLQ 118
             LA R++++ EA R +        ELR Q +E  +R R+AE+   RQ+    E  QR  +
Sbjct: 1484 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1543

Query: 119  QLLHRERDGVVRQARELQRQLAEELVN----RGHCSRPGASEVSAAQCRCRLQEVLAQLR 174
              L  +R     +  +L+R L EE V     R    R    +  A + R   +  L   R
Sbjct: 1544 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE--R 1601

Query: 175  WQTDGEQAARIRYLQAALEVERQLFLKYILAHFRGHPA-----LSGSPDPQAVHSLE--- 226
            WQ    +A R+R LQA  EV +Q  L    A  +   A       G  + QAV   E   
Sbjct: 1602 WQLKANEALRLR-LQAE-EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1659

Query: 227  ---EPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVRSRSL------GLVSSACSSSP--- 274
               E   Q + G+      A Q         E G + R L       L   A +++    
Sbjct: 1660 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1719

Query: 275  --DGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSPDTSTPGSRRLSPPPSPL 332
              +  L+   + ++    + +R+ + +RS  + SK        +      R L+   + L
Sbjct: 1720 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR-----LEAEAGRFRELAEEAARL 1774

Query: 333  PPPPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHHELIKLNWLLA-KALWVLARRC 391
                  +  ++           ++   VL      +G    +K    +A K       R 
Sbjct: 1775 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1834

Query: 392  YTLQE----ENKQLRRAGCPYQADEKVKRLKVKRAELTGLARR---LADRARELQETNLR 444
              L E    + ++L      ++AD + +  ++++A  + L R+   + D  R+ ++    
Sbjct: 1835 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1894

Query: 445  AVSAPIPGESCAG----LELCQVFARQRARDL---SEQASAPLAKDKQI----EELRQEC 493
             ++     E  A     LEL     R  A D     EQA    A+ +Q+    E  R+E 
Sbjct: 1895 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1954

Query: 494  HLLQARVASGPCSDLHTGRGGPCTQWLNVRDLDRL-------QRESQREVLRLQRQLMLQ 546
               + RV     ++    R         + +++RL       +R  +R      RQL L 
Sbjct: 1955 ---EERVQKSLAAEEEAARQRKAA----LEEVERLKAKVEEARRLRERAEQESARQLQLA 2007

Query: 547  QGNGGAWPEAGGQSATCEE------VRRQMLALERELDQRRRECQELGTQAAPARRRGEE 600
            Q       EA  +    EE      V+++   L++ L Q +    +L  +A  ARR  EE
Sbjct: 2008 Q-------EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2060

Query: 601  AE--------------------------TQLQAALLKNAWLAEENGRLQAKTDWVRKVEA 634
            AE                           + QA     A  A E  R +A+ +  R+ +A
Sbjct: 2061 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2120

Query: 635  ENSEVRGHLGRACQERDASGLIAEQLLQQAARGQD-----RQQQLQRDPQKALCDLHPSW 689
            E + +R     A  E +     AEQ L+Q A+ +      R Q  + D QK L D     
Sbjct: 2121 EQAALR-QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD----- 2174

Query: 690  KEIQALQCRPGHPPEQPWETSQMPES------QVKGSRRPKFHARPEDYAVSQPNRD--- 740
            +E+Q L+       E   + SQ+ E       Q++   + K     E+ A+   ++D   
Sbjct: 2175 EELQRLK---AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2231

Query: 741  --IQEKREASLEES------PVALGESASVPQVSETVPASQ 773
              +QE+ E   + +       VA  E+A + Q++E   A Q
Sbjct: 2232 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2272



 Score = 57.8 bits (138), Expect = 9e-08
 Identities = 177/803 (22%), Positives = 310/803 (38%), Gaps = 77/803 (9%)

Query: 34   EKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELRQLQE 93
            E LR   E ER    AE++R   RER    EA  E+++      ++ +AQ  RE ++LQ+
Sbjct: 1307 ETLRRMEEEERL---AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1363

Query: 94   EMQRE---RE---AEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQR---QLAEE-- 142
             MQ E   RE    + +Q  R  + E +QL+Q    E     RQA   +R   ++ EE  
Sbjct: 1364 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1423

Query: 143  ---LVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQLF 199
               L       + G +E      R R +E  AQ R     E+A R+R  Q   E +R+  
Sbjct: 1424 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ--EEAERLR-RQVQDESQRKRQ 1480

Query: 200  LKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVR 259
             +  LA      A +     +A+ +LEE   Q         +   +      ++ E   R
Sbjct: 1481 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1540

Query: 260  SRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSP---- 315
            S    L S   S +        +   +  A A  R     R+  +A     R  +     
Sbjct: 1541 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1600

Query: 316  ----DTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHH 371
                  +     RL             +   K       E       E        L   
Sbjct: 1601 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1660

Query: 372  ELIKLNWL--------LAKALWVLARRCYTLQ-EENKQL---------RRAGCPYQADEK 413
            EL K   L        LA    ++  R  T Q E+ +QL         R A    Q  ++
Sbjct: 1661 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1720

Query: 414  VK-RLKVKRAELTGLARRLADRARELQETNLRAVSAPIPGESCAG--LELCQVFARQRAR 470
            ++  L   RAE+  L   LA +AR  +E+   +  +    E+ AG   EL +  AR RA 
Sbjct: 1721 LEAELAKVRAEMEVL---LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1777

Query: 471  DLSEQASAPLAKDKQIEELRQECHLLQARVAS-GPCSDLHTGRGGPCTQWLNVRDLDRLQ 529
                +    LA++    +  +   +L  ++A+ G  + L T       +     + +RL+
Sbjct: 1778 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE--KEAENERLR 1835

Query: 530  RESQREVLRLQRQLMLQQGNGGAWPE---AGGQSATCEEVRRQMLALERELDQRRRECQE 586
            R ++ E  + +R+L  Q     A  E   A  + A+  E+ RQ   +E  L QRR+  +E
Sbjct: 1836 RLAEDEAFQ-RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1894

Query: 587  -LGTQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGR 645
             L  +A+  +    +AE +L+   +++        + QA+ +  R+ +    E R    R
Sbjct: 1895 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR--R 1952

Query: 646  ACQERDASGLIAEQLLQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQ 705
              +ER    L AE+  + A + +   ++++R        L    +E + L+ R      +
Sbjct: 1953 EAEERVQKSLAAEE--EAARQRKAALEEVER--------LKAKVEEARRLRER-----AE 1997

Query: 706  PWETSQMPESQVKGSRRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQV 765
                 Q+  +Q    +R +   +   +AV Q  +++Q+  +          GE+ +  + 
Sbjct: 1998 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2057

Query: 766  SETVPASQPLSKKTSSQSNSSSE 788
            +E    ++  +++ ++QS    E
Sbjct: 2058 AEEAEEARVQAEREAAQSRRQVE 2080



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 59/188 (31%), Positives = 89/188 (47%), Gaps = 24/188 (12%)

Query: 23   AAVLENQRRELE-KLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWE 81
            AA  E +RRE E +++  L AE     A R+R AA E   R +A+ E    A RLR + E
Sbjct: 1944 AAEEERRRREAEERVQKSLAAEE---EAARQRKAALEEVERLKAKVEE---ARRLRERAE 1997

Query: 82   AQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGV--VRQARELQRQL 139
             + +R+L+  QE  Q+  +AE +      + ++++LQQ L +E+  +  +R   E  R+ 
Sbjct: 1998 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2057

Query: 140  AEELVN-RGHCSRPGA--------------SEVSAAQCRCRLQEVLAQLRWQTDGEQAAR 184
            AEE    R    R  A              S    AQ R + Q    +LR + + E A R
Sbjct: 2058 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2117

Query: 185  IRYLQAAL 192
             +  QAAL
Sbjct: 2118 AQAEQAAL 2125



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 52/191 (27%), Positives = 96/191 (50%), Gaps = 23/191 (12%)

Query: 24   AVLENQRRELEKLR-AELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEA 82
            +VL+  R E E  R A  EAE A  +AER   AA+ R+  EEAER ++   ++ +++ +A
Sbjct: 2042 SVLDQLRGEAEAARRAAEEAEEARVQAERE--AAQSRRQVEEAERLKQSAEEQAQARAQA 2099

Query: 83   QRSRELRQLQEEMQREREAEIRQ-LLRWKEAEQRQLQQLLHRE-RDGVVRQARELQRQLA 140
            Q + E  + + E +  R A+  Q  LR K+A   ++++  H++  +  +RQ  +++++L 
Sbjct: 2100 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK--HKKFAEQTLRQKAQVEQELT 2157

Query: 141  E---ELVNRGH--------CSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQ 189
                +L    H          R  A    AA+ R +++E L  +R Q +      +  L+
Sbjct: 2158 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME-----ELSKLK 2212

Query: 190  AALEVERQLFL 200
            A +E E +  +
Sbjct: 2213 ARIEAENRALI 2223



 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 56/186 (30%), Positives = 89/186 (47%), Gaps = 20/186 (10%)

Query: 29   QRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSREL 88
            Q  EL KL+A +EAE        +     +R L+EEAE+ ++   +  R    AQ +  L
Sbjct: 2204 QMEELSKLKARIEAENRALILRDKDNT--QRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2261

Query: 89   RQLQEEMQREREAEIRQLLRWK-----EAEQRQLQ-QLLHRERDGVVRQARELQ------ 136
            RQL EE   ++ A   ++L+ K     EA + + + +LL ++++    QAR LQ      
Sbjct: 2262 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2321

Query: 137  -RQLAEE---LVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAAL 192
             +QLAEE           R    E+SA   R +L+ V    R Q   E+ A+ R+ + A 
Sbjct: 2322 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR-VAEMSRAQARAEEDAQ-RFRKQAE 2379

Query: 193  EVERQL 198
            E+  +L
Sbjct: 2380 EIGEKL 2385



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 56/204 (27%), Positives = 81/204 (39%), Gaps = 46/204 (22%)

Query: 24   AVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQ 83
            A L+ +     + R ELEAE A  RAE     A     +  AE E R  +++ + + EA+
Sbjct: 1705 ARLQREAAAATQKRQELEAELAKVRAEMEVLLAS----KARAEEESRSTSEKSKQRLEAE 1760

Query: 84   RSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEEL 143
              R  R+L EE  R R       L  +   QRQL +      +   RQ  E +R LAE+L
Sbjct: 1761 AGR-FRELAEEAARLR------ALAEEAKRQRQLAE------EDAARQRAEAERVLAEKL 1807

Query: 144  VNRGHCSRPGAS-----------------------------EVSAAQCRCRLQEVLAQLR 174
               G  +R                                 E  AAQ +  ++E LAQLR
Sbjct: 1808 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1867

Query: 175  WQTDGEQAARIRYLQAALEVERQL 198
              +D E   +   ++  L   RQ+
Sbjct: 1868 KASDSELERQKGLVEDTLRQRRQV 1891



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 58/189 (30%), Positives = 90/189 (47%), Gaps = 36/189 (19%)

Query: 32   ELEKLRAEL-EAERAGWRAERRRFAARER-----QLREEAERERRQLADRLRSKWEAQR- 84
            EL++L+AE  EA R   + E   F+ R +     +L+   E E R L   LR K   QR 
Sbjct: 2176 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI--LRDKDNTQRF 2233

Query: 85   ----SRELRQLQEEMQR-----EREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQAREL 135
                + +++Q+ EE  R     +  A +RQL     A+QR L + + +E+   V++A  L
Sbjct: 2234 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2293

Query: 136  QRQLAEELVNRGHCSRPGASEVSAAQCRCRLQE----VLAQLRWQTDGEQ----AARIRY 187
            + +   EL+ +         E++  Q R RLQE    +  QL  +T G Q    A R R 
Sbjct: 2294 KAE--AELLQQ-------QKELAQEQAR-RLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2343

Query: 188  LQAALEVER 196
            L+ + E ER
Sbjct: 2344 LEMSAEAER 2352



 Score = 44.7 bits (104), Expect = 8e-04
 Identities = 33/122 (27%), Positives = 67/122 (54%), Gaps = 11/122 (9%)

Query: 40   LEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQRER 99
            +E E+A      +   A+ +QLREE +R+++Q+        E +R R +  ++E  +R+ 
Sbjct: 2477 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM--------EQERQRLVASMEEARRRQH 2528

Query: 100  EAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSA 159
            EAE  + +R K+ E +QL+Q   ++ + +  + + L+ QL + L  +   +   + EV+A
Sbjct: 2529 EAE--EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL-QLLEEQHRAALAHSEEVTA 2585

Query: 160  AQ 161
            +Q
Sbjct: 2586 SQ 2587



 Score = 41.2 bits (95), Expect = 0.008
 Identities = 34/125 (27%), Positives = 61/125 (48%), Gaps = 20/125 (16%)

Query: 30   RRELEKLRAELEAERAGWRAERRRFAARER------------QLREEAERERRQLADRLR 77
            R E +  R   +AE  G +  R   A +E+            Q   +AER R  +A+  R
Sbjct: 2366 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2425

Query: 78   SKWEAQRSRELRQLQ-EEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQ 136
             K + Q+  +L QL+ EEMQ  ++ ++ Q       E + LQQ    E+D ++++ R ++
Sbjct: 2426 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQ-------ETQALQQSFLSEKDSLLQRERFIE 2478

Query: 137  RQLAE 141
            ++ A+
Sbjct: 2479 QEKAK 2483



 Score = 40.8 bits (94), Expect = 0.011
 Identities = 88/420 (20%), Positives = 163/420 (38%), Gaps = 63/420 (15%)

Query: 375  KLNWLLAKALWVLARRCYTLQEENK--QLRRAGCPYQADEKVKRLKVKRAELTGLARRLA 432
            +L  L ++ +  ++     ++EE +  + +RA    +  E    L+ +R      A+  A
Sbjct: 1293 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1352

Query: 433  DRARELQETNLRAVSAPIPGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQE 492
               RE +E   R     +  E  A      V A+Q+ R + E+          +++LRQ 
Sbjct: 1353 QAEREAKELQQRMQEEVVRREEAA------VDAQQQKRSIQEE----------LQQLRQS 1396

Query: 493  CHL-LQARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQQGNGG 551
                +QA+      ++                   RL+ E +  V+RLQ +   +Q  GG
Sbjct: 1397 SEAEIQAKARQAEAAER-----------------SRLRIEEEIRVVRLQLEATERQ-RGG 1438

Query: 552  AWPEAGGQSATCEEVRRQMLALERELDQRRRECQELGTQAAPARRRGEEAETQLQAALLK 611
            A  E     A  EE   Q    + E ++ RR+ Q+         +R  +AE +L + +  
Sbjct: 1439 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD-------ESQRKRQAEVELASRVKA 1491

Query: 612  NAWLAEENGR-LQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQLLQQAARGQ-- 668
             A  A E  R LQA  +   +++AE +E R  L +A  ER     +A +  Q++A  +  
Sbjct: 1492 EAEAAREKQRALQALEE--LRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQ 1547

Query: 669  -------DRQQQLQRDPQK---ALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVK 718
                   ++  QL+R  Q+   A+  L    +     Q       E+     ++   Q+K
Sbjct: 1548 SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE--AERELERWQLK 1605

Query: 719  GSRRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKK 778
             +   +   + E+ A  +     + +++    E        A    V +   A Q L K+
Sbjct: 1606 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1665



 Score = 40.4 bits (93), Expect = 0.014
 Identities = 40/140 (28%), Positives = 65/140 (46%), Gaps = 20/140 (14%)

Query: 26   LENQRRELEKLRAELEAERAGWRAER----------RRFAARERQLREEAERERRQLADR 75
            LE  +  L+KLRA+ EA++  + A R           R   R  +   E ER R ++A +
Sbjct: 1093 LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA-Q 1151

Query: 76   LRSKWEA------QRSRELRQLQEEMQREREA--EIRQLLRWKEAEQRQLQQLLHRERDG 127
            L  +W+A       R REL QL  +++  RE+   +   L+     Q Q+Q +   +   
Sbjct: 1152 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1211

Query: 128  VVRQARELQRQLAEELVNRG 147
            V  Q R+ ++ L EE+   G
Sbjct: 1212 VREQLRQ-EQALLEEIERHG 1230



 Score = 39.7 bits (91), Expect = 0.024
 Identities = 42/174 (24%), Positives = 72/174 (41%), Gaps = 7/174 (4%)

Query: 24   AVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQ 83
            A +E  R+    L     +  A  +++R  FA +  QL    + E   +A +LR   EA+
Sbjct: 1523 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA-QLRE--EAE 1579

Query: 84   RSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEEL 143
            R     Q Q E +R RE   R+L RW+      L+  L  E     +   + + +  +E 
Sbjct: 1580 RRA---QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1636

Query: 144  VNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQ 197
              R    R G +E  A + R   ++ L + R   +G    R+   Q  + +  +
Sbjct: 1637 AER-EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE 1689



 Score = 39.7 bits (91), Expect = 0.024
 Identities = 53/186 (28%), Positives = 84/186 (45%), Gaps = 16/186 (8%)

Query: 23   AAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWE- 81
            AA L    +E  +LR   E + A  RA   +    + Q  +EA R + + A+ L+ + E 
Sbjct: 2248 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE-AELLQQQKEL 2306

Query: 82   -AQRSRELRQLQEEMQREREAEIRQLLRWKEAE-QRQLQQLLHRERDGVVRQARELQRQL 139
              +++R L++ +E+M ++   E +   R  EAE QRQL+     ER  +        +  
Sbjct: 2307 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2366

Query: 140  AEELVNRGHCSRPGASEVS--------AAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAA 191
            AEE   R    R  A E+         A Q +  L + L   R Q+D   A R+R   A 
Sbjct: 2367 AEEDAQR---FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD-HDAERLREAIAE 2422

Query: 192  LEVERQ 197
            LE E++
Sbjct: 2423 LEREKE 2428



 Score = 38.5 bits (88), Expect = 0.054
 Identities = 35/136 (25%), Positives = 67/136 (49%), Gaps = 20/136 (14%)

Query: 26   LENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRS 85
            +E ++ +LE+L  +  A+    R E++R   +++Q+ +E +R    + +  R + EA   
Sbjct: 2477 IEQEKAKLEQLFQDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEA--- 2530

Query: 86   RELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVN 145
                   EE  R ++ E++QL    E ++RQ ++LL  E   +  Q + L+ Q    L  
Sbjct: 2531 -------EEGVRRKQEELQQL----EQQRRQQEELLAEENQRLREQLQLLEEQHRAAL-- 2577

Query: 146  RGHCSRPGASEVSAAQ 161
              H     AS+V+A +
Sbjct: 2578 -AHSEEVTASQVAATK 2592



 Score = 37.7 bits (86), Expect = 0.092
 Identities = 38/136 (27%), Positives = 71/136 (52%), Gaps = 16/136 (11%)

Query: 26   LENQRRE----LEKLR---AELEAERAGWRAERRRFAARERQLR----EEAERERRQLAD 74
            LE QR++     E+LR   AELE E+   + E +    +  +++    E+  +E + L  
Sbjct: 2402 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2461

Query: 75   RLRSKWEA--QRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQA 132
               S+ ++  QR R + Q + ++++  + E+ +  + +E +QRQ QQ + +ER  +V   
Sbjct: 2462 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASM 2520

Query: 133  RELQRQL--AEELVNR 146
             E +R+   AEE V R
Sbjct: 2521 EEARRRQHEAEEGVRR 2536



 Score = 36.6 bits (83), Expect = 0.21
 Identities = 55/186 (29%), Positives = 82/186 (44%), Gaps = 23/186 (12%)

Query: 23   AAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERE--RRQLADR--LRS 78
            AA    Q  E E+L+   E E+A  RA+ +   A   +LR+EAE+E  RR  A++  LR 
Sbjct: 2072 AAQSRRQVEEAERLKQSAE-EQAQARAQAQ---AAAEKLRKEAEQEAARRAQAEQAALRQ 2127

Query: 79   KWEAQRSRELRQLQEEMQREREAEIRQ---LLRWKEAEQRQLQQLLHRERDGVVRQAREL 135
            K  A    E  +   E    ++A++ Q    LR +  E    + LL  E   +  +A E 
Sbjct: 2128 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2187

Query: 136  QR---QLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAAL 192
             R   Q+ EEL +     R    E+S  + R   +     LR   D  Q    R+LQ   
Sbjct: 2188 ARQRSQVEEELFS----VRVQMEELSKLKARIEAENRALILR-DKDNTQ----RFLQEEA 2238

Query: 193  EVERQL 198
            E  +Q+
Sbjct: 2239 EKMKQV 2244



 Score = 36.6 bits (83), Expect = 0.21
 Identities = 54/231 (23%), Positives = 100/231 (43%), Gaps = 36/231 (15%)

Query: 413  KVKRLKVKRAELTGL-------ARRLADRARELQETNLRAVSAPIPGESCAGLELCQVFA 465
            + +RLK++ AE++         A+R   +A E+ E   R   A    E    ++  ++  
Sbjct: 2349 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT--QEKVTLVQTLEIQR 2406

Query: 466  RQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPCSDLHTGRGGPCTQWLNVRDL 525
            +Q   D      A    +++ E+L+QE  LLQ +       ++ T +     Q   +++ 
Sbjct: 2407 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLK-----SEEMQTVQ-----QEQLLQET 2456

Query: 526  DRLQRE--SQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRRE 583
              LQ+   S+++ L LQR+  ++Q           + A  +++R +    +++++Q R  
Sbjct: 2457 QALQQSFLSEKDSL-LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER-- 2513

Query: 584  CQELGTQAAPARRRGEEAETQL-----------QAALLKNAWLAEENGRLQ 623
             Q L      ARRR  EAE  +           Q    +   LAEEN RL+
Sbjct: 2514 -QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2563



 Score = 33.1 bits (74), Expect = 2.3
 Identities = 34/121 (28%), Positives = 52/121 (42%), Gaps = 12/121 (9%)

Query: 22   AAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLR------EEAERERRQLADR 75
            A  + E Q+R+ +++  E +   A     RRR    E  +R      ++ E++RRQ  + 
Sbjct: 2495 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2554

Query: 76   LRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQAREL 135
            L    E QR RE  QL EE  R   A   ++     A Q    + L   RD +   A E 
Sbjct: 2555 LAE--ENQRLREQLQLLEEQHRAALAHSEEV----TASQVAATKTLPNGRDALDGPAAEA 2608

Query: 136  Q 136
            +
Sbjct: 2609 E 2609


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 203/881 (23%), Positives = 333/881 (37%), Gaps = 164/881 (18%)

Query: 25   VLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQ------------- 71
            V+  Q    E+ R   E E    RA      A++RQ +EEAER RRQ             
Sbjct: 1593 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1652

Query: 72   -LADRLRSKWEAQRSR--------ELR-QLQEEMQREREAEI---RQLLRWKEAEQRQLQ 118
             LA R++++ EA R +        ELR Q +E  +R R+AE+   RQ+    E  QR  +
Sbjct: 1653 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1712

Query: 119  QLLHRERDGVVRQARELQRQLAEELVN----RGHCSRPGASEVSAAQCRCRLQEVLAQLR 174
              L  +R     +  +L+R L EE V     R    R    +  A + R   +  L   R
Sbjct: 1713 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE--R 1770

Query: 175  WQTDGEQAARIRYLQAALEVERQLFLKYILAHFRGHPA-----LSGSPDPQAVHSLE--- 226
            WQ    +A R+R LQA  EV +Q  L    A  +   A       G  + QAV   E   
Sbjct: 1771 WQLKANEALRLR-LQAE-EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1828

Query: 227  ---EPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVRSRSL------GLVSSACSSSP--- 274
               E   Q + G+      A Q         E G + R L       L   A +++    
Sbjct: 1829 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1888

Query: 275  --DGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSPDTSTPGSRRLSPPPSPL 332
              +  L+   + ++    + +R+ + +RS  + SK        +      R L+   + L
Sbjct: 1889 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR-----LEAEAGRFRELAEEAARL 1943

Query: 333  PPPPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHHELIKLNWLLA-KALWVLARRC 391
                  +  ++           ++   VL      +G    +K    +A K       R 
Sbjct: 1944 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 2003

Query: 392  YTLQE----ENKQLRRAGCPYQADEKVKRLKVKRAELTGLARR---LADRARELQETNLR 444
              L E    + ++L      ++AD + +  ++++A  + L R+   + D  R+ ++    
Sbjct: 2004 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 2063

Query: 445  AVSAPIPGESCAG----LELCQVFARQRARDL---SEQASAPLAKDKQI----EELRQEC 493
             ++     E  A     LEL     R  A D     EQA    A+ +Q+    E  R+E 
Sbjct: 2064 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 2123

Query: 494  HLLQARVASGPCSDLHTGRGGPCTQWLNVRDLDRL-------QRESQREVLRLQRQLMLQ 546
               + RV     ++    R         + +++RL       +R  +R      RQL L 
Sbjct: 2124 ---EERVQKSLAAEEEAARQRKAA----LEEVERLKAKVEEARRLRERAEQESARQLQLA 2176

Query: 547  QGNGGAWPEAGGQSATCEE------VRRQMLALERELDQRRRECQELGTQAAPARRRGEE 600
            Q       EA  +    EE      V+++   L++ L Q +    +L  +A  ARR  EE
Sbjct: 2177 Q-------EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2229

Query: 601  AE--------------------------TQLQAALLKNAWLAEENGRLQAKTDWVRKVEA 634
            AE                           + QA     A  A E  R +A+ +  R+ +A
Sbjct: 2230 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2289

Query: 635  ENSEVRGHLGRACQERDASGLIAEQLLQQAARGQD-----RQQQLQRDPQKALCDLHPSW 689
            E + +R     A  E +     AEQ L+Q A+ +      R Q  + D QK L D     
Sbjct: 2290 EQAALR-QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD----- 2343

Query: 690  KEIQALQCRPGHPPEQPWETSQMPES------QVKGSRRPKFHARPEDYAVSQPNRD--- 740
            +E+Q L+       E   + SQ+ E       Q++   + K     E+ A+   ++D   
Sbjct: 2344 EELQRLK---AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2400

Query: 741  --IQEKREASLEES------PVALGESASVPQVSETVPASQ 773
              +QE+ E   + +       VA  E+A + Q++E   A Q
Sbjct: 2401 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2441



 Score = 57.8 bits (138), Expect = 9e-08
 Identities = 177/803 (22%), Positives = 310/803 (38%), Gaps = 77/803 (9%)

Query: 34   EKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELRQLQE 93
            E LR   E ER    AE++R   RER    EA  E+++      ++ +AQ  RE ++LQ+
Sbjct: 1476 ETLRRMEEEERL---AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1532

Query: 94   EMQRE---RE---AEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQR---QLAEE-- 142
             MQ E   RE    + +Q  R  + E +QL+Q    E     RQA   +R   ++ EE  
Sbjct: 1533 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1592

Query: 143  ---LVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQLF 199
               L       + G +E      R R +E  AQ R     E+A R+R  Q   E +R+  
Sbjct: 1593 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ--EEAERLR-RQVQDESQRKRQ 1649

Query: 200  LKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVR 259
             +  LA      A +     +A+ +LEE   Q         +   +      ++ E   R
Sbjct: 1650 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1709

Query: 260  SRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSP---- 315
            S    L S   S +        +   +  A A  R     R+  +A     R  +     
Sbjct: 1710 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1769

Query: 316  ----DTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHH 371
                  +     RL             +   K       E       E        L   
Sbjct: 1770 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1829

Query: 372  ELIKLNWL--------LAKALWVLARRCYTLQ-EENKQL---------RRAGCPYQADEK 413
            EL K   L        LA    ++  R  T Q E+ +QL         R A    Q  ++
Sbjct: 1830 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1889

Query: 414  VK-RLKVKRAELTGLARRLADRARELQETNLRAVSAPIPGESCAG--LELCQVFARQRAR 470
            ++  L   RAE+  L   LA +AR  +E+   +  +    E+ AG   EL +  AR RA 
Sbjct: 1890 LEAELAKVRAEMEVL---LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1946

Query: 471  DLSEQASAPLAKDKQIEELRQECHLLQARVAS-GPCSDLHTGRGGPCTQWLNVRDLDRLQ 529
                +    LA++    +  +   +L  ++A+ G  + L T       +     + +RL+
Sbjct: 1947 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE--KEAENERLR 2004

Query: 530  RESQREVLRLQRQLMLQQGNGGAWPE---AGGQSATCEEVRRQMLALERELDQRRRECQE 586
            R ++ E  + +R+L  Q     A  E   A  + A+  E+ RQ   +E  L QRR+  +E
Sbjct: 2005 RLAEDEAFQ-RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 2063

Query: 587  -LGTQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGR 645
             L  +A+  +    +AE +L+   +++        + QA+ +  R+ +    E R    R
Sbjct: 2064 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR--R 2121

Query: 646  ACQERDASGLIAEQLLQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQ 705
              +ER    L AE+  + A + +   ++++R        L    +E + L+ R      +
Sbjct: 2122 EAEERVQKSLAAEE--EAARQRKAALEEVER--------LKAKVEEARRLRER-----AE 2166

Query: 706  PWETSQMPESQVKGSRRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQV 765
                 Q+  +Q    +R +   +   +AV Q  +++Q+  +          GE+ +  + 
Sbjct: 2167 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2226

Query: 766  SETVPASQPLSKKTSSQSNSSSE 788
            +E    ++  +++ ++QS    E
Sbjct: 2227 AEEAEEARVQAEREAAQSRRQVE 2249



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 59/188 (31%), Positives = 89/188 (47%), Gaps = 24/188 (12%)

Query: 23   AAVLENQRRELE-KLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWE 81
            AA  E +RRE E +++  L AE     A R+R AA E   R +A+ E    A RLR + E
Sbjct: 2113 AAEEERRRREAEERVQKSLAAEE---EAARQRKAALEEVERLKAKVEE---ARRLRERAE 2166

Query: 82   AQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGV--VRQARELQRQL 139
             + +R+L+  QE  Q+  +AE +      + ++++LQQ L +E+  +  +R   E  R+ 
Sbjct: 2167 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2226

Query: 140  AEELVN-RGHCSRPGA--------------SEVSAAQCRCRLQEVLAQLRWQTDGEQAAR 184
            AEE    R    R  A              S    AQ R + Q    +LR + + E A R
Sbjct: 2227 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2286

Query: 185  IRYLQAAL 192
             +  QAAL
Sbjct: 2287 AQAEQAAL 2294



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 52/191 (27%), Positives = 96/191 (50%), Gaps = 23/191 (12%)

Query: 24   AVLENQRRELEKLR-AELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEA 82
            +VL+  R E E  R A  EAE A  +AER   AA+ R+  EEAER ++   ++ +++ +A
Sbjct: 2211 SVLDQLRGEAEAARRAAEEAEEARVQAERE--AAQSRRQVEEAERLKQSAEEQAQARAQA 2268

Query: 83   QRSRELRQLQEEMQREREAEIRQ-LLRWKEAEQRQLQQLLHRE-RDGVVRQARELQRQLA 140
            Q + E  + + E +  R A+  Q  LR K+A   ++++  H++  +  +RQ  +++++L 
Sbjct: 2269 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK--HKKFAEQTLRQKAQVEQELT 2326

Query: 141  E---ELVNRGH--------CSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQ 189
                +L    H          R  A    AA+ R +++E L  +R Q +      +  L+
Sbjct: 2327 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME-----ELSKLK 2381

Query: 190  AALEVERQLFL 200
            A +E E +  +
Sbjct: 2382 ARIEAENRALI 2392



 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 56/186 (30%), Positives = 89/186 (47%), Gaps = 20/186 (10%)

Query: 29   QRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSREL 88
            Q  EL KL+A +EAE        +     +R L+EEAE+ ++   +  R    AQ +  L
Sbjct: 2373 QMEELSKLKARIEAENRALILRDKDNT--QRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2430

Query: 89   RQLQEEMQREREAEIRQLLRWK-----EAEQRQLQ-QLLHRERDGVVRQARELQ------ 136
            RQL EE   ++ A   ++L+ K     EA + + + +LL ++++    QAR LQ      
Sbjct: 2431 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2490

Query: 137  -RQLAEE---LVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAAL 192
             +QLAEE           R    E+SA   R +L+ V    R Q   E+ A+ R+ + A 
Sbjct: 2491 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR-VAEMSRAQARAEEDAQ-RFRKQAE 2548

Query: 193  EVERQL 198
            E+  +L
Sbjct: 2549 EIGEKL 2554



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 56/204 (27%), Positives = 81/204 (39%), Gaps = 46/204 (22%)

Query: 24   AVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQ 83
            A L+ +     + R ELEAE A  RAE     A     +  AE E R  +++ + + EA+
Sbjct: 1874 ARLQREAAAATQKRQELEAELAKVRAEMEVLLAS----KARAEEESRSTSEKSKQRLEAE 1929

Query: 84   RSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEEL 143
              R  R+L EE  R R       L  +   QRQL +      +   RQ  E +R LAE+L
Sbjct: 1930 AGR-FRELAEEAARLR------ALAEEAKRQRQLAE------EDAARQRAEAERVLAEKL 1976

Query: 144  VNRGHCSRPGAS-----------------------------EVSAAQCRCRLQEVLAQLR 174
               G  +R                                 E  AAQ +  ++E LAQLR
Sbjct: 1977 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 2036

Query: 175  WQTDGEQAARIRYLQAALEVERQL 198
              +D E   +   ++  L   RQ+
Sbjct: 2037 KASDSELERQKGLVEDTLRQRRQV 2060



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 58/189 (30%), Positives = 90/189 (47%), Gaps = 36/189 (19%)

Query: 32   ELEKLRAEL-EAERAGWRAERRRFAARER-----QLREEAERERRQLADRLRSKWEAQR- 84
            EL++L+AE  EA R   + E   F+ R +     +L+   E E R L   LR K   QR 
Sbjct: 2345 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI--LRDKDNTQRF 2402

Query: 85   ----SRELRQLQEEMQR-----EREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQAREL 135
                + +++Q+ EE  R     +  A +RQL     A+QR L + + +E+   V++A  L
Sbjct: 2403 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2462

Query: 136  QRQLAEELVNRGHCSRPGASEVSAAQCRCRLQE----VLAQLRWQTDGEQ----AARIRY 187
            + +   EL+ +         E++  Q R RLQE    +  QL  +T G Q    A R R 
Sbjct: 2463 KAE--AELLQQ-------QKELAQEQAR-RLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2512

Query: 188  LQAALEVER 196
            L+ + E ER
Sbjct: 2513 LEMSAEAER 2521



 Score = 44.7 bits (104), Expect = 8e-04
 Identities = 33/122 (27%), Positives = 67/122 (54%), Gaps = 11/122 (9%)

Query: 40   LEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQRER 99
            +E E+A      +   A+ +QLREE +R+++Q+        E +R R +  ++E  +R+ 
Sbjct: 2646 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM--------EQERQRLVASMEEARRRQH 2697

Query: 100  EAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSA 159
            EAE  + +R K+ E +QL+Q   ++ + +  + + L+ QL + L  +   +   + EV+A
Sbjct: 2698 EAE--EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL-QLLEEQHRAALAHSEEVTA 2754

Query: 160  AQ 161
            +Q
Sbjct: 2755 SQ 2756



 Score = 41.2 bits (95), Expect = 0.008
 Identities = 34/125 (27%), Positives = 61/125 (48%), Gaps = 20/125 (16%)

Query: 30   RRELEKLRAELEAERAGWRAERRRFAARER------------QLREEAERERRQLADRLR 77
            R E +  R   +AE  G +  R   A +E+            Q   +AER R  +A+  R
Sbjct: 2535 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2594

Query: 78   SKWEAQRSRELRQLQ-EEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQ 136
             K + Q+  +L QL+ EEMQ  ++ ++ Q       E + LQQ    E+D ++++ R ++
Sbjct: 2595 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQ-------ETQALQQSFLSEKDSLLQRERFIE 2647

Query: 137  RQLAE 141
            ++ A+
Sbjct: 2648 QEKAK 2652



 Score = 40.8 bits (94), Expect = 0.011
 Identities = 88/420 (20%), Positives = 163/420 (38%), Gaps = 63/420 (15%)

Query: 375  KLNWLLAKALWVLARRCYTLQEENK--QLRRAGCPYQADEKVKRLKVKRAELTGLARRLA 432
            +L  L ++ +  ++     ++EE +  + +RA    +  E    L+ +R      A+  A
Sbjct: 1462 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1521

Query: 433  DRARELQETNLRAVSAPIPGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQE 492
               RE +E   R     +  E  A      V A+Q+ R + E+          +++LRQ 
Sbjct: 1522 QAEREAKELQQRMQEEVVRREEAA------VDAQQQKRSIQEE----------LQQLRQS 1565

Query: 493  CHL-LQARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQQGNGG 551
                +QA+      ++                   RL+ E +  V+RLQ +   +Q  GG
Sbjct: 1566 SEAEIQAKARQAEAAER-----------------SRLRIEEEIRVVRLQLEATERQ-RGG 1607

Query: 552  AWPEAGGQSATCEEVRRQMLALERELDQRRRECQELGTQAAPARRRGEEAETQLQAALLK 611
            A  E     A  EE   Q    + E ++ RR+ Q+         +R  +AE +L + +  
Sbjct: 1608 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD-------ESQRKRQAEVELASRVKA 1660

Query: 612  NAWLAEENGR-LQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQLLQQAARGQ-- 668
             A  A E  R LQA  +   +++AE +E R  L +A  ER     +A +  Q++A  +  
Sbjct: 1661 EAEAAREKQRALQALEE--LRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQ 1716

Query: 669  -------DRQQQLQRDPQK---ALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVK 718
                   ++  QL+R  Q+   A+  L    +     Q       E+     ++   Q+K
Sbjct: 1717 SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE--AERELERWQLK 1774

Query: 719  GSRRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKK 778
             +   +   + E+ A  +     + +++    E        A    V +   A Q L K+
Sbjct: 1775 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1834



 Score = 40.4 bits (93), Expect = 0.014
 Identities = 40/140 (28%), Positives = 65/140 (46%), Gaps = 20/140 (14%)

Query: 26   LENQRRELEKLRAELEAERAGWRAER----------RRFAARERQLREEAERERRQLADR 75
            LE  +  L+KLRA+ EA++  + A R           R   R  +   E ER R ++A +
Sbjct: 1262 LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA-Q 1320

Query: 76   LRSKWEA------QRSRELRQLQEEMQREREA--EIRQLLRWKEAEQRQLQQLLHRERDG 127
            L  +W+A       R REL QL  +++  RE+   +   L+     Q Q+Q +   +   
Sbjct: 1321 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1380

Query: 128  VVRQARELQRQLAEELVNRG 147
            V  Q R+ ++ L EE+   G
Sbjct: 1381 VREQLRQ-EQALLEEIERHG 1399



 Score = 39.7 bits (91), Expect = 0.024
 Identities = 42/174 (24%), Positives = 72/174 (41%), Gaps = 7/174 (4%)

Query: 24   AVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQ 83
            A +E  R+    L     +  A  +++R  FA +  QL    + E   +A +LR   EA+
Sbjct: 1692 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA-QLRE--EAE 1748

Query: 84   RSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEEL 143
            R     Q Q E +R RE   R+L RW+      L+  L  E     +   + + +  +E 
Sbjct: 1749 RRA---QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1805

Query: 144  VNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQ 197
              R    R G +E  A + R   ++ L + R   +G    R+   Q  + +  +
Sbjct: 1806 AER-EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE 1858



 Score = 39.7 bits (91), Expect = 0.024
 Identities = 53/186 (28%), Positives = 84/186 (45%), Gaps = 16/186 (8%)

Query: 23   AAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWE- 81
            AA L    +E  +LR   E + A  RA   +    + Q  +EA R + + A+ L+ + E 
Sbjct: 2417 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE-AELLQQQKEL 2475

Query: 82   -AQRSRELRQLQEEMQREREAEIRQLLRWKEAE-QRQLQQLLHRERDGVVRQARELQRQL 139
              +++R L++ +E+M ++   E +   R  EAE QRQL+     ER  +        +  
Sbjct: 2476 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2535

Query: 140  AEELVNRGHCSRPGASEVS--------AAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAA 191
            AEE   R    R  A E+         A Q +  L + L   R Q+D   A R+R   A 
Sbjct: 2536 AEEDAQR---FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD-HDAERLREAIAE 2591

Query: 192  LEVERQ 197
            LE E++
Sbjct: 2592 LEREKE 2597



 Score = 38.5 bits (88), Expect = 0.054
 Identities = 35/136 (25%), Positives = 67/136 (49%), Gaps = 20/136 (14%)

Query: 26   LENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRS 85
            +E ++ +LE+L  +  A+    R E++R   +++Q+ +E +R    + +  R + EA   
Sbjct: 2646 IEQEKAKLEQLFQDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEA--- 2699

Query: 86   RELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVN 145
                   EE  R ++ E++QL    E ++RQ ++LL  E   +  Q + L+ Q    L  
Sbjct: 2700 -------EEGVRRKQEELQQL----EQQRRQQEELLAEENQRLREQLQLLEEQHRAAL-- 2746

Query: 146  RGHCSRPGASEVSAAQ 161
              H     AS+V+A +
Sbjct: 2747 -AHSEEVTASQVAATK 2761



 Score = 37.7 bits (86), Expect = 0.092
 Identities = 38/136 (27%), Positives = 71/136 (52%), Gaps = 16/136 (11%)

Query: 26   LENQRRE----LEKLR---AELEAERAGWRAERRRFAARERQLR----EEAERERRQLAD 74
            LE QR++     E+LR   AELE E+   + E +    +  +++    E+  +E + L  
Sbjct: 2571 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2630

Query: 75   RLRSKWEA--QRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQA 132
               S+ ++  QR R + Q + ++++  + E+ +  + +E +QRQ QQ + +ER  +V   
Sbjct: 2631 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASM 2689

Query: 133  RELQRQL--AEELVNR 146
             E +R+   AEE V R
Sbjct: 2690 EEARRRQHEAEEGVRR 2705



 Score = 36.6 bits (83), Expect = 0.21
 Identities = 55/186 (29%), Positives = 82/186 (44%), Gaps = 23/186 (12%)

Query: 23   AAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERE--RRQLADR--LRS 78
            AA    Q  E E+L+   E E+A  RA+ +   A   +LR+EAE+E  RR  A++  LR 
Sbjct: 2241 AAQSRRQVEEAERLKQSAE-EQAQARAQAQ---AAAEKLRKEAEQEAARRAQAEQAALRQ 2296

Query: 79   KWEAQRSRELRQLQEEMQREREAEIRQ---LLRWKEAEQRQLQQLLHRERDGVVRQAREL 135
            K  A    E  +   E    ++A++ Q    LR +  E    + LL  E   +  +A E 
Sbjct: 2297 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2356

Query: 136  QR---QLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAAL 192
             R   Q+ EEL +     R    E+S  + R   +     LR   D  Q    R+LQ   
Sbjct: 2357 ARQRSQVEEELFS----VRVQMEELSKLKARIEAENRALILR-DKDNTQ----RFLQEEA 2407

Query: 193  EVERQL 198
            E  +Q+
Sbjct: 2408 EKMKQV 2413



 Score = 36.6 bits (83), Expect = 0.21
 Identities = 54/231 (23%), Positives = 100/231 (43%), Gaps = 36/231 (15%)

Query: 413  KVKRLKVKRAELTGL-------ARRLADRARELQETNLRAVSAPIPGESCAGLELCQVFA 465
            + +RLK++ AE++         A+R   +A E+ E   R   A    E    ++  ++  
Sbjct: 2518 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT--QEKVTLVQTLEIQR 2575

Query: 466  RQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPCSDLHTGRGGPCTQWLNVRDL 525
            +Q   D      A    +++ E+L+QE  LLQ +       ++ T +     Q   +++ 
Sbjct: 2576 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLK-----SEEMQTVQ-----QEQLLQET 2625

Query: 526  DRLQRE--SQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRRE 583
              LQ+   S+++ L LQR+  ++Q           + A  +++R +    +++++Q R  
Sbjct: 2626 QALQQSFLSEKDSL-LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER-- 2682

Query: 584  CQELGTQAAPARRRGEEAETQL-----------QAALLKNAWLAEENGRLQ 623
             Q L      ARRR  EAE  +           Q    +   LAEEN RL+
Sbjct: 2683 -QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2732



 Score = 33.1 bits (74), Expect = 2.3
 Identities = 34/121 (28%), Positives = 52/121 (42%), Gaps = 12/121 (9%)

Query: 22   AAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLR------EEAERERRQLADR 75
            A  + E Q+R+ +++  E +   A     RRR    E  +R      ++ E++RRQ  + 
Sbjct: 2664 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2723

Query: 76   LRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQAREL 135
            L    E QR RE  QL EE  R   A   ++     A Q    + L   RD +   A E 
Sbjct: 2724 LAE--ENQRLREQLQLLEEQHRAALAHSEEV----TASQVAATKTLPNGRDALDGPAAEA 2777

Query: 136  Q 136
            +
Sbjct: 2778 E 2778


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 203/881 (23%), Positives = 333/881 (37%), Gaps = 164/881 (18%)

Query: 25   VLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQ------------- 71
            V+  Q    E+ R   E E    RA      A++RQ +EEAER RRQ             
Sbjct: 1434 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1493

Query: 72   -LADRLRSKWEAQRSR--------ELR-QLQEEMQREREAEI---RQLLRWKEAEQRQLQ 118
             LA R++++ EA R +        ELR Q +E  +R R+AE+   RQ+    E  QR  +
Sbjct: 1494 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1553

Query: 119  QLLHRERDGVVRQARELQRQLAEELVN----RGHCSRPGASEVSAAQCRCRLQEVLAQLR 174
              L  +R     +  +L+R L EE V     R    R    +  A + R   +  L   R
Sbjct: 1554 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE--R 1611

Query: 175  WQTDGEQAARIRYLQAALEVERQLFLKYILAHFRGHPA-----LSGSPDPQAVHSLE--- 226
            WQ    +A R+R LQA  EV +Q  L    A  +   A       G  + QAV   E   
Sbjct: 1612 WQLKANEALRLR-LQAE-EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1669

Query: 227  ---EPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVRSRSL------GLVSSACSSSP--- 274
               E   Q + G+      A Q         E G + R L       L   A +++    
Sbjct: 1670 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1729

Query: 275  --DGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSPDTSTPGSRRLSPPPSPL 332
              +  L+   + ++    + +R+ + +RS  + SK        +      R L+   + L
Sbjct: 1730 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR-----LEAEAGRFRELAEEAARL 1784

Query: 333  PPPPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHHELIKLNWLLA-KALWVLARRC 391
                  +  ++           ++   VL      +G    +K    +A K       R 
Sbjct: 1785 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1844

Query: 392  YTLQE----ENKQLRRAGCPYQADEKVKRLKVKRAELTGLARR---LADRARELQETNLR 444
              L E    + ++L      ++AD + +  ++++A  + L R+   + D  R+ ++    
Sbjct: 1845 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1904

Query: 445  AVSAPIPGESCAG----LELCQVFARQRARDL---SEQASAPLAKDKQI----EELRQEC 493
             ++     E  A     LEL     R  A D     EQA    A+ +Q+    E  R+E 
Sbjct: 1905 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1964

Query: 494  HLLQARVASGPCSDLHTGRGGPCTQWLNVRDLDRL-------QRESQREVLRLQRQLMLQ 546
               + RV     ++    R         + +++RL       +R  +R      RQL L 
Sbjct: 1965 ---EERVQKSLAAEEEAARQRKAA----LEEVERLKAKVEEARRLRERAEQESARQLQLA 2017

Query: 547  QGNGGAWPEAGGQSATCEE------VRRQMLALERELDQRRRECQELGTQAAPARRRGEE 600
            Q       EA  +    EE      V+++   L++ L Q +    +L  +A  ARR  EE
Sbjct: 2018 Q-------EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2070

Query: 601  AE--------------------------TQLQAALLKNAWLAEENGRLQAKTDWVRKVEA 634
            AE                           + QA     A  A E  R +A+ +  R+ +A
Sbjct: 2071 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2130

Query: 635  ENSEVRGHLGRACQERDASGLIAEQLLQQAARGQD-----RQQQLQRDPQKALCDLHPSW 689
            E + +R     A  E +     AEQ L+Q A+ +      R Q  + D QK L D     
Sbjct: 2131 EQAALR-QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD----- 2184

Query: 690  KEIQALQCRPGHPPEQPWETSQMPES------QVKGSRRPKFHARPEDYAVSQPNRD--- 740
            +E+Q L+       E   + SQ+ E       Q++   + K     E+ A+   ++D   
Sbjct: 2185 EELQRLK---AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2241

Query: 741  --IQEKREASLEES------PVALGESASVPQVSETVPASQ 773
              +QE+ E   + +       VA  E+A + Q++E   A Q
Sbjct: 2242 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2282



 Score = 57.8 bits (138), Expect = 9e-08
 Identities = 177/803 (22%), Positives = 310/803 (38%), Gaps = 77/803 (9%)

Query: 34   EKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELRQLQE 93
            E LR   E ER    AE++R   RER    EA  E+++      ++ +AQ  RE ++LQ+
Sbjct: 1317 ETLRRMEEEERL---AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1373

Query: 94   EMQRE---RE---AEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQR---QLAEE-- 142
             MQ E   RE    + +Q  R  + E +QL+Q    E     RQA   +R   ++ EE  
Sbjct: 1374 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1433

Query: 143  ---LVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQLF 199
               L       + G +E      R R +E  AQ R     E+A R+R  Q   E +R+  
Sbjct: 1434 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ--EEAERLR-RQVQDESQRKRQ 1490

Query: 200  LKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVR 259
             +  LA      A +     +A+ +LEE   Q         +   +      ++ E   R
Sbjct: 1491 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1550

Query: 260  SRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSP---- 315
            S    L S   S +        +   +  A A  R     R+  +A     R  +     
Sbjct: 1551 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1610

Query: 316  ----DTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHH 371
                  +     RL             +   K       E       E        L   
Sbjct: 1611 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1670

Query: 372  ELIKLNWL--------LAKALWVLARRCYTLQ-EENKQL---------RRAGCPYQADEK 413
            EL K   L        LA    ++  R  T Q E+ +QL         R A    Q  ++
Sbjct: 1671 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1730

Query: 414  VK-RLKVKRAELTGLARRLADRARELQETNLRAVSAPIPGESCAG--LELCQVFARQRAR 470
            ++  L   RAE+  L   LA +AR  +E+   +  +    E+ AG   EL +  AR RA 
Sbjct: 1731 LEAELAKVRAEMEVL---LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1787

Query: 471  DLSEQASAPLAKDKQIEELRQECHLLQARVAS-GPCSDLHTGRGGPCTQWLNVRDLDRLQ 529
                +    LA++    +  +   +L  ++A+ G  + L T       +     + +RL+
Sbjct: 1788 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE--KEAENERLR 1845

Query: 530  RESQREVLRLQRQLMLQQGNGGAWPE---AGGQSATCEEVRRQMLALERELDQRRRECQE 586
            R ++ E  + +R+L  Q     A  E   A  + A+  E+ RQ   +E  L QRR+  +E
Sbjct: 1846 RLAEDEAFQ-RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1904

Query: 587  -LGTQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGR 645
             L  +A+  +    +AE +L+   +++        + QA+ +  R+ +    E R    R
Sbjct: 1905 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR--R 1962

Query: 646  ACQERDASGLIAEQLLQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQ 705
              +ER    L AE+  + A + +   ++++R        L    +E + L+ R      +
Sbjct: 1963 EAEERVQKSLAAEE--EAARQRKAALEEVER--------LKAKVEEARRLRER-----AE 2007

Query: 706  PWETSQMPESQVKGSRRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQV 765
                 Q+  +Q    +R +   +   +AV Q  +++Q+  +          GE+ +  + 
Sbjct: 2008 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2067

Query: 766  SETVPASQPLSKKTSSQSNSSSE 788
            +E    ++  +++ ++QS    E
Sbjct: 2068 AEEAEEARVQAEREAAQSRRQVE 2090



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 59/188 (31%), Positives = 89/188 (47%), Gaps = 24/188 (12%)

Query: 23   AAVLENQRRELE-KLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWE 81
            AA  E +RRE E +++  L AE     A R+R AA E   R +A+ E    A RLR + E
Sbjct: 1954 AAEEERRRREAEERVQKSLAAEE---EAARQRKAALEEVERLKAKVEE---ARRLRERAE 2007

Query: 82   AQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGV--VRQARELQRQL 139
             + +R+L+  QE  Q+  +AE +      + ++++LQQ L +E+  +  +R   E  R+ 
Sbjct: 2008 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2067

Query: 140  AEELVN-RGHCSRPGA--------------SEVSAAQCRCRLQEVLAQLRWQTDGEQAAR 184
            AEE    R    R  A              S    AQ R + Q    +LR + + E A R
Sbjct: 2068 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2127

Query: 185  IRYLQAAL 192
             +  QAAL
Sbjct: 2128 AQAEQAAL 2135



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 52/191 (27%), Positives = 96/191 (50%), Gaps = 23/191 (12%)

Query: 24   AVLENQRRELEKLR-AELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEA 82
            +VL+  R E E  R A  EAE A  +AER   AA+ R+  EEAER ++   ++ +++ +A
Sbjct: 2052 SVLDQLRGEAEAARRAAEEAEEARVQAERE--AAQSRRQVEEAERLKQSAEEQAQARAQA 2109

Query: 83   QRSRELRQLQEEMQREREAEIRQ-LLRWKEAEQRQLQQLLHRE-RDGVVRQARELQRQLA 140
            Q + E  + + E +  R A+  Q  LR K+A   ++++  H++  +  +RQ  +++++L 
Sbjct: 2110 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK--HKKFAEQTLRQKAQVEQELT 2167

Query: 141  E---ELVNRGH--------CSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQ 189
                +L    H          R  A    AA+ R +++E L  +R Q +      +  L+
Sbjct: 2168 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME-----ELSKLK 2222

Query: 190  AALEVERQLFL 200
            A +E E +  +
Sbjct: 2223 ARIEAENRALI 2233



 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 56/186 (30%), Positives = 89/186 (47%), Gaps = 20/186 (10%)

Query: 29   QRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSREL 88
            Q  EL KL+A +EAE        +     +R L+EEAE+ ++   +  R    AQ +  L
Sbjct: 2214 QMEELSKLKARIEAENRALILRDKDNT--QRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2271

Query: 89   RQLQEEMQREREAEIRQLLRWK-----EAEQRQLQ-QLLHRERDGVVRQARELQ------ 136
            RQL EE   ++ A   ++L+ K     EA + + + +LL ++++    QAR LQ      
Sbjct: 2272 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2331

Query: 137  -RQLAEE---LVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAAL 192
             +QLAEE           R    E+SA   R +L+ V    R Q   E+ A+ R+ + A 
Sbjct: 2332 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR-VAEMSRAQARAEEDAQ-RFRKQAE 2389

Query: 193  EVERQL 198
            E+  +L
Sbjct: 2390 EIGEKL 2395



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 56/204 (27%), Positives = 81/204 (39%), Gaps = 46/204 (22%)

Query: 24   AVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQ 83
            A L+ +     + R ELEAE A  RAE     A     +  AE E R  +++ + + EA+
Sbjct: 1715 ARLQREAAAATQKRQELEAELAKVRAEMEVLLAS----KARAEEESRSTSEKSKQRLEAE 1770

Query: 84   RSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEEL 143
              R  R+L EE  R R       L  +   QRQL +      +   RQ  E +R LAE+L
Sbjct: 1771 AGR-FRELAEEAARLR------ALAEEAKRQRQLAE------EDAARQRAEAERVLAEKL 1817

Query: 144  VNRGHCSRPGAS-----------------------------EVSAAQCRCRLQEVLAQLR 174
               G  +R                                 E  AAQ +  ++E LAQLR
Sbjct: 1818 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1877

Query: 175  WQTDGEQAARIRYLQAALEVERQL 198
              +D E   +   ++  L   RQ+
Sbjct: 1878 KASDSELERQKGLVEDTLRQRRQV 1901



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 58/189 (30%), Positives = 90/189 (47%), Gaps = 36/189 (19%)

Query: 32   ELEKLRAEL-EAERAGWRAERRRFAARER-----QLREEAERERRQLADRLRSKWEAQR- 84
            EL++L+AE  EA R   + E   F+ R +     +L+   E E R L   LR K   QR 
Sbjct: 2186 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI--LRDKDNTQRF 2243

Query: 85   ----SRELRQLQEEMQR-----EREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQAREL 135
                + +++Q+ EE  R     +  A +RQL     A+QR L + + +E+   V++A  L
Sbjct: 2244 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2303

Query: 136  QRQLAEELVNRGHCSRPGASEVSAAQCRCRLQE----VLAQLRWQTDGEQ----AARIRY 187
            + +   EL+ +         E++  Q R RLQE    +  QL  +T G Q    A R R 
Sbjct: 2304 KAE--AELLQQ-------QKELAQEQAR-RLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2353

Query: 188  LQAALEVER 196
            L+ + E ER
Sbjct: 2354 LEMSAEAER 2362



 Score = 44.7 bits (104), Expect = 8e-04
 Identities = 33/122 (27%), Positives = 67/122 (54%), Gaps = 11/122 (9%)

Query: 40   LEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQRER 99
            +E E+A      +   A+ +QLREE +R+++Q+        E +R R +  ++E  +R+ 
Sbjct: 2487 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM--------EQERQRLVASMEEARRRQH 2538

Query: 100  EAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSA 159
            EAE  + +R K+ E +QL+Q   ++ + +  + + L+ QL + L  +   +   + EV+A
Sbjct: 2539 EAE--EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL-QLLEEQHRAALAHSEEVTA 2595

Query: 160  AQ 161
            +Q
Sbjct: 2596 SQ 2597



 Score = 41.2 bits (95), Expect = 0.008
 Identities = 34/125 (27%), Positives = 61/125 (48%), Gaps = 20/125 (16%)

Query: 30   RRELEKLRAELEAERAGWRAERRRFAARER------------QLREEAERERRQLADRLR 77
            R E +  R   +AE  G +  R   A +E+            Q   +AER R  +A+  R
Sbjct: 2376 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2435

Query: 78   SKWEAQRSRELRQLQ-EEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQ 136
             K + Q+  +L QL+ EEMQ  ++ ++ Q       E + LQQ    E+D ++++ R ++
Sbjct: 2436 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQ-------ETQALQQSFLSEKDSLLQRERFIE 2488

Query: 137  RQLAE 141
            ++ A+
Sbjct: 2489 QEKAK 2493



 Score = 40.8 bits (94), Expect = 0.011
 Identities = 88/420 (20%), Positives = 163/420 (38%), Gaps = 63/420 (15%)

Query: 375  KLNWLLAKALWVLARRCYTLQEENK--QLRRAGCPYQADEKVKRLKVKRAELTGLARRLA 432
            +L  L ++ +  ++     ++EE +  + +RA    +  E    L+ +R      A+  A
Sbjct: 1303 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1362

Query: 433  DRARELQETNLRAVSAPIPGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQE 492
               RE +E   R     +  E  A      V A+Q+ R + E+          +++LRQ 
Sbjct: 1363 QAEREAKELQQRMQEEVVRREEAA------VDAQQQKRSIQEE----------LQQLRQS 1406

Query: 493  CHL-LQARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQQGNGG 551
                +QA+      ++                   RL+ E +  V+RLQ +   +Q  GG
Sbjct: 1407 SEAEIQAKARQAEAAER-----------------SRLRIEEEIRVVRLQLEATERQ-RGG 1448

Query: 552  AWPEAGGQSATCEEVRRQMLALERELDQRRRECQELGTQAAPARRRGEEAETQLQAALLK 611
            A  E     A  EE   Q    + E ++ RR+ Q+         +R  +AE +L + +  
Sbjct: 1449 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD-------ESQRKRQAEVELASRVKA 1501

Query: 612  NAWLAEENGR-LQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQLLQQAARGQ-- 668
             A  A E  R LQA  +   +++AE +E R  L +A  ER     +A +  Q++A  +  
Sbjct: 1502 EAEAAREKQRALQALEE--LRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQ 1557

Query: 669  -------DRQQQLQRDPQK---ALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVK 718
                   ++  QL+R  Q+   A+  L    +     Q       E+     ++   Q+K
Sbjct: 1558 SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE--AERELERWQLK 1615

Query: 719  GSRRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKK 778
             +   +   + E+ A  +     + +++    E        A    V +   A Q L K+
Sbjct: 1616 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1675



 Score = 40.4 bits (93), Expect = 0.014
 Identities = 40/140 (28%), Positives = 65/140 (46%), Gaps = 20/140 (14%)

Query: 26   LENQRRELEKLRAELEAERAGWRAER----------RRFAARERQLREEAERERRQLADR 75
            LE  +  L+KLRA+ EA++  + A R           R   R  +   E ER R ++A +
Sbjct: 1103 LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA-Q 1161

Query: 76   LRSKWEA------QRSRELRQLQEEMQREREA--EIRQLLRWKEAEQRQLQQLLHRERDG 127
            L  +W+A       R REL QL  +++  RE+   +   L+     Q Q+Q +   +   
Sbjct: 1162 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1221

Query: 128  VVRQARELQRQLAEELVNRG 147
            V  Q R+ ++ L EE+   G
Sbjct: 1222 VREQLRQ-EQALLEEIERHG 1240



 Score = 39.7 bits (91), Expect = 0.024
 Identities = 42/174 (24%), Positives = 72/174 (41%), Gaps = 7/174 (4%)

Query: 24   AVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQ 83
            A +E  R+    L     +  A  +++R  FA +  QL    + E   +A +LR   EA+
Sbjct: 1533 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA-QLRE--EAE 1589

Query: 84   RSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEEL 143
            R     Q Q E +R RE   R+L RW+      L+  L  E     +   + + +  +E 
Sbjct: 1590 RRA---QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1646

Query: 144  VNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQ 197
              R    R G +E  A + R   ++ L + R   +G    R+   Q  + +  +
Sbjct: 1647 AER-EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE 1699



 Score = 39.7 bits (91), Expect = 0.024
 Identities = 53/186 (28%), Positives = 84/186 (45%), Gaps = 16/186 (8%)

Query: 23   AAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWE- 81
            AA L    +E  +LR   E + A  RA   +    + Q  +EA R + + A+ L+ + E 
Sbjct: 2258 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE-AELLQQQKEL 2316

Query: 82   -AQRSRELRQLQEEMQREREAEIRQLLRWKEAE-QRQLQQLLHRERDGVVRQARELQRQL 139
              +++R L++ +E+M ++   E +   R  EAE QRQL+     ER  +        +  
Sbjct: 2317 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2376

Query: 140  AEELVNRGHCSRPGASEVS--------AAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAA 191
            AEE   R    R  A E+         A Q +  L + L   R Q+D   A R+R   A 
Sbjct: 2377 AEEDAQR---FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD-HDAERLREAIAE 2432

Query: 192  LEVERQ 197
            LE E++
Sbjct: 2433 LEREKE 2438



 Score = 38.5 bits (88), Expect = 0.054
 Identities = 35/136 (25%), Positives = 67/136 (49%), Gaps = 20/136 (14%)

Query: 26   LENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRS 85
            +E ++ +LE+L  +  A+    R E++R   +++Q+ +E +R    + +  R + EA   
Sbjct: 2487 IEQEKAKLEQLFQDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEA--- 2540

Query: 86   RELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVN 145
                   EE  R ++ E++QL    E ++RQ ++LL  E   +  Q + L+ Q    L  
Sbjct: 2541 -------EEGVRRKQEELQQL----EQQRRQQEELLAEENQRLREQLQLLEEQHRAAL-- 2587

Query: 146  RGHCSRPGASEVSAAQ 161
              H     AS+V+A +
Sbjct: 2588 -AHSEEVTASQVAATK 2602



 Score = 37.7 bits (86), Expect = 0.092
 Identities = 38/136 (27%), Positives = 71/136 (52%), Gaps = 16/136 (11%)

Query: 26   LENQRRE----LEKLR---AELEAERAGWRAERRRFAARERQLR----EEAERERRQLAD 74
            LE QR++     E+LR   AELE E+   + E +    +  +++    E+  +E + L  
Sbjct: 2412 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2471

Query: 75   RLRSKWEA--QRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQA 132
               S+ ++  QR R + Q + ++++  + E+ +  + +E +QRQ QQ + +ER  +V   
Sbjct: 2472 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASM 2530

Query: 133  RELQRQL--AEELVNR 146
             E +R+   AEE V R
Sbjct: 2531 EEARRRQHEAEEGVRR 2546



 Score = 36.6 bits (83), Expect = 0.21
 Identities = 55/186 (29%), Positives = 82/186 (44%), Gaps = 23/186 (12%)

Query: 23   AAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERE--RRQLADR--LRS 78
            AA    Q  E E+L+   E E+A  RA+ +   A   +LR+EAE+E  RR  A++  LR 
Sbjct: 2082 AAQSRRQVEEAERLKQSAE-EQAQARAQAQ---AAAEKLRKEAEQEAARRAQAEQAALRQ 2137

Query: 79   KWEAQRSRELRQLQEEMQREREAEIRQ---LLRWKEAEQRQLQQLLHRERDGVVRQAREL 135
            K  A    E  +   E    ++A++ Q    LR +  E    + LL  E   +  +A E 
Sbjct: 2138 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2197

Query: 136  QR---QLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAAL 192
             R   Q+ EEL +     R    E+S  + R   +     LR   D  Q    R+LQ   
Sbjct: 2198 ARQRSQVEEELFS----VRVQMEELSKLKARIEAENRALILR-DKDNTQ----RFLQEEA 2248

Query: 193  EVERQL 198
            E  +Q+
Sbjct: 2249 EKMKQV 2254



 Score = 36.6 bits (83), Expect = 0.21
 Identities = 54/231 (23%), Positives = 100/231 (43%), Gaps = 36/231 (15%)

Query: 413  KVKRLKVKRAELTGL-------ARRLADRARELQETNLRAVSAPIPGESCAGLELCQVFA 465
            + +RLK++ AE++         A+R   +A E+ E   R   A    E    ++  ++  
Sbjct: 2359 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT--QEKVTLVQTLEIQR 2416

Query: 466  RQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPCSDLHTGRGGPCTQWLNVRDL 525
            +Q   D      A    +++ E+L+QE  LLQ +       ++ T +     Q   +++ 
Sbjct: 2417 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLK-----SEEMQTVQ-----QEQLLQET 2466

Query: 526  DRLQRE--SQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRRE 583
              LQ+   S+++ L LQR+  ++Q           + A  +++R +    +++++Q R  
Sbjct: 2467 QALQQSFLSEKDSL-LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER-- 2523

Query: 584  CQELGTQAAPARRRGEEAETQL-----------QAALLKNAWLAEENGRLQ 623
             Q L      ARRR  EAE  +           Q    +   LAEEN RL+
Sbjct: 2524 -QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2573



 Score = 33.1 bits (74), Expect = 2.3
 Identities = 34/121 (28%), Positives = 52/121 (42%), Gaps = 12/121 (9%)

Query: 22   AAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLR------EEAERERRQLADR 75
            A  + E Q+R+ +++  E +   A     RRR    E  +R      ++ E++RRQ  + 
Sbjct: 2505 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2564

Query: 76   LRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQAREL 135
            L    E QR RE  QL EE  R   A   ++     A Q    + L   RD +   A E 
Sbjct: 2565 LAE--ENQRLREQLQLLEEQHRAALAHSEEV----TASQVAATKTLPNGRDALDGPAAEA 2618

Query: 136  Q 136
            +
Sbjct: 2619 E 2619


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 203/881 (23%), Positives = 333/881 (37%), Gaps = 164/881 (18%)

Query: 25   VLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQ------------- 71
            V+  Q    E+ R   E E    RA      A++RQ +EEAER RRQ             
Sbjct: 1442 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1501

Query: 72   -LADRLRSKWEAQRSR--------ELR-QLQEEMQREREAEI---RQLLRWKEAEQRQLQ 118
             LA R++++ EA R +        ELR Q +E  +R R+AE+   RQ+    E  QR  +
Sbjct: 1502 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1561

Query: 119  QLLHRERDGVVRQARELQRQLAEELVN----RGHCSRPGASEVSAAQCRCRLQEVLAQLR 174
              L  +R     +  +L+R L EE V     R    R    +  A + R   +  L   R
Sbjct: 1562 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE--R 1619

Query: 175  WQTDGEQAARIRYLQAALEVERQLFLKYILAHFRGHPA-----LSGSPDPQAVHSLE--- 226
            WQ    +A R+R LQA  EV +Q  L    A  +   A       G  + QAV   E   
Sbjct: 1620 WQLKANEALRLR-LQAE-EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1677

Query: 227  ---EPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVRSRSL------GLVSSACSSSP--- 274
               E   Q + G+      A Q         E G + R L       L   A +++    
Sbjct: 1678 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1737

Query: 275  --DGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSPDTSTPGSRRLSPPPSPL 332
              +  L+   + ++    + +R+ + +RS  + SK        +      R L+   + L
Sbjct: 1738 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR-----LEAEAGRFRELAEEAARL 1792

Query: 333  PPPPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHHELIKLNWLLA-KALWVLARRC 391
                  +  ++           ++   VL      +G    +K    +A K       R 
Sbjct: 1793 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1852

Query: 392  YTLQE----ENKQLRRAGCPYQADEKVKRLKVKRAELTGLARR---LADRARELQETNLR 444
              L E    + ++L      ++AD + +  ++++A  + L R+   + D  R+ ++    
Sbjct: 1853 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1912

Query: 445  AVSAPIPGESCAG----LELCQVFARQRARDL---SEQASAPLAKDKQI----EELRQEC 493
             ++     E  A     LEL     R  A D     EQA    A+ +Q+    E  R+E 
Sbjct: 1913 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1972

Query: 494  HLLQARVASGPCSDLHTGRGGPCTQWLNVRDLDRL-------QRESQREVLRLQRQLMLQ 546
               + RV     ++    R         + +++RL       +R  +R      RQL L 
Sbjct: 1973 ---EERVQKSLAAEEEAARQRKAA----LEEVERLKAKVEEARRLRERAEQESARQLQLA 2025

Query: 547  QGNGGAWPEAGGQSATCEE------VRRQMLALERELDQRRRECQELGTQAAPARRRGEE 600
            Q       EA  +    EE      V+++   L++ L Q +    +L  +A  ARR  EE
Sbjct: 2026 Q-------EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2078

Query: 601  AE--------------------------TQLQAALLKNAWLAEENGRLQAKTDWVRKVEA 634
            AE                           + QA     A  A E  R +A+ +  R+ +A
Sbjct: 2079 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2138

Query: 635  ENSEVRGHLGRACQERDASGLIAEQLLQQAARGQD-----RQQQLQRDPQKALCDLHPSW 689
            E + +R     A  E +     AEQ L+Q A+ +      R Q  + D QK L D     
Sbjct: 2139 EQAALR-QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD----- 2192

Query: 690  KEIQALQCRPGHPPEQPWETSQMPES------QVKGSRRPKFHARPEDYAVSQPNRD--- 740
            +E+Q L+       E   + SQ+ E       Q++   + K     E+ A+   ++D   
Sbjct: 2193 EELQRLK---AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2249

Query: 741  --IQEKREASLEES------PVALGESASVPQVSETVPASQ 773
              +QE+ E   + +       VA  E+A + Q++E   A Q
Sbjct: 2250 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2290



 Score = 57.8 bits (138), Expect = 9e-08
 Identities = 177/803 (22%), Positives = 310/803 (38%), Gaps = 77/803 (9%)

Query: 34   EKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELRQLQE 93
            E LR   E ER    AE++R   RER    EA  E+++      ++ +AQ  RE ++LQ+
Sbjct: 1325 ETLRRMEEEERL---AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1381

Query: 94   EMQRE---RE---AEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQR---QLAEE-- 142
             MQ E   RE    + +Q  R  + E +QL+Q    E     RQA   +R   ++ EE  
Sbjct: 1382 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1441

Query: 143  ---LVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQLF 199
               L       + G +E      R R +E  AQ R     E+A R+R  Q   E +R+  
Sbjct: 1442 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ--EEAERLR-RQVQDESQRKRQ 1498

Query: 200  LKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVR 259
             +  LA      A +     +A+ +LEE   Q         +   +      ++ E   R
Sbjct: 1499 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1558

Query: 260  SRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSP---- 315
            S    L S   S +        +   +  A A  R     R+  +A     R  +     
Sbjct: 1559 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1618

Query: 316  ----DTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHH 371
                  +     RL             +   K       E       E        L   
Sbjct: 1619 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1678

Query: 372  ELIKLNWL--------LAKALWVLARRCYTLQ-EENKQL---------RRAGCPYQADEK 413
            EL K   L        LA    ++  R  T Q E+ +QL         R A    Q  ++
Sbjct: 1679 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1738

Query: 414  VK-RLKVKRAELTGLARRLADRARELQETNLRAVSAPIPGESCAG--LELCQVFARQRAR 470
            ++  L   RAE+  L   LA +AR  +E+   +  +    E+ AG   EL +  AR RA 
Sbjct: 1739 LEAELAKVRAEMEVL---LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1795

Query: 471  DLSEQASAPLAKDKQIEELRQECHLLQARVAS-GPCSDLHTGRGGPCTQWLNVRDLDRLQ 529
                +    LA++    +  +   +L  ++A+ G  + L T       +     + +RL+
Sbjct: 1796 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE--KEAENERLR 1853

Query: 530  RESQREVLRLQRQLMLQQGNGGAWPE---AGGQSATCEEVRRQMLALERELDQRRRECQE 586
            R ++ E  + +R+L  Q     A  E   A  + A+  E+ RQ   +E  L QRR+  +E
Sbjct: 1854 RLAEDEAFQ-RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1912

Query: 587  -LGTQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGR 645
             L  +A+  +    +AE +L+   +++        + QA+ +  R+ +    E R    R
Sbjct: 1913 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR--R 1970

Query: 646  ACQERDASGLIAEQLLQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQ 705
              +ER    L AE+  + A + +   ++++R        L    +E + L+ R      +
Sbjct: 1971 EAEERVQKSLAAEE--EAARQRKAALEEVER--------LKAKVEEARRLRER-----AE 2015

Query: 706  PWETSQMPESQVKGSRRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQV 765
                 Q+  +Q    +R +   +   +AV Q  +++Q+  +          GE+ +  + 
Sbjct: 2016 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2075

Query: 766  SETVPASQPLSKKTSSQSNSSSE 788
            +E    ++  +++ ++QS    E
Sbjct: 2076 AEEAEEARVQAEREAAQSRRQVE 2098



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 59/188 (31%), Positives = 89/188 (47%), Gaps = 24/188 (12%)

Query: 23   AAVLENQRRELE-KLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWE 81
            AA  E +RRE E +++  L AE     A R+R AA E   R +A+ E    A RLR + E
Sbjct: 1962 AAEEERRRREAEERVQKSLAAEE---EAARQRKAALEEVERLKAKVEE---ARRLRERAE 2015

Query: 82   AQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGV--VRQARELQRQL 139
             + +R+L+  QE  Q+  +AE +      + ++++LQQ L +E+  +  +R   E  R+ 
Sbjct: 2016 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2075

Query: 140  AEELVN-RGHCSRPGA--------------SEVSAAQCRCRLQEVLAQLRWQTDGEQAAR 184
            AEE    R    R  A              S    AQ R + Q    +LR + + E A R
Sbjct: 2076 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2135

Query: 185  IRYLQAAL 192
             +  QAAL
Sbjct: 2136 AQAEQAAL 2143



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 52/191 (27%), Positives = 96/191 (50%), Gaps = 23/191 (12%)

Query: 24   AVLENQRRELEKLR-AELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEA 82
            +VL+  R E E  R A  EAE A  +AER   AA+ R+  EEAER ++   ++ +++ +A
Sbjct: 2060 SVLDQLRGEAEAARRAAEEAEEARVQAERE--AAQSRRQVEEAERLKQSAEEQAQARAQA 2117

Query: 83   QRSRELRQLQEEMQREREAEIRQ-LLRWKEAEQRQLQQLLHRE-RDGVVRQARELQRQLA 140
            Q + E  + + E +  R A+  Q  LR K+A   ++++  H++  +  +RQ  +++++L 
Sbjct: 2118 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK--HKKFAEQTLRQKAQVEQELT 2175

Query: 141  E---ELVNRGH--------CSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQ 189
                +L    H          R  A    AA+ R +++E L  +R Q +      +  L+
Sbjct: 2176 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME-----ELSKLK 2230

Query: 190  AALEVERQLFL 200
            A +E E +  +
Sbjct: 2231 ARIEAENRALI 2241



 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 56/186 (30%), Positives = 89/186 (47%), Gaps = 20/186 (10%)

Query: 29   QRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSREL 88
            Q  EL KL+A +EAE        +     +R L+EEAE+ ++   +  R    AQ +  L
Sbjct: 2222 QMEELSKLKARIEAENRALILRDKDNT--QRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2279

Query: 89   RQLQEEMQREREAEIRQLLRWK-----EAEQRQLQ-QLLHRERDGVVRQARELQ------ 136
            RQL EE   ++ A   ++L+ K     EA + + + +LL ++++    QAR LQ      
Sbjct: 2280 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2339

Query: 137  -RQLAEE---LVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAAL 192
             +QLAEE           R    E+SA   R +L+ V    R Q   E+ A+ R+ + A 
Sbjct: 2340 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR-VAEMSRAQARAEEDAQ-RFRKQAE 2397

Query: 193  EVERQL 198
            E+  +L
Sbjct: 2398 EIGEKL 2403



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 56/204 (27%), Positives = 81/204 (39%), Gaps = 46/204 (22%)

Query: 24   AVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQ 83
            A L+ +     + R ELEAE A  RAE     A     +  AE E R  +++ + + EA+
Sbjct: 1723 ARLQREAAAATQKRQELEAELAKVRAEMEVLLAS----KARAEEESRSTSEKSKQRLEAE 1778

Query: 84   RSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEEL 143
              R  R+L EE  R R       L  +   QRQL +      +   RQ  E +R LAE+L
Sbjct: 1779 AGR-FRELAEEAARLR------ALAEEAKRQRQLAE------EDAARQRAEAERVLAEKL 1825

Query: 144  VNRGHCSRPGAS-----------------------------EVSAAQCRCRLQEVLAQLR 174
               G  +R                                 E  AAQ +  ++E LAQLR
Sbjct: 1826 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1885

Query: 175  WQTDGEQAARIRYLQAALEVERQL 198
              +D E   +   ++  L   RQ+
Sbjct: 1886 KASDSELERQKGLVEDTLRQRRQV 1909



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 58/189 (30%), Positives = 90/189 (47%), Gaps = 36/189 (19%)

Query: 32   ELEKLRAEL-EAERAGWRAERRRFAARER-----QLREEAERERRQLADRLRSKWEAQR- 84
            EL++L+AE  EA R   + E   F+ R +     +L+   E E R L   LR K   QR 
Sbjct: 2194 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI--LRDKDNTQRF 2251

Query: 85   ----SRELRQLQEEMQR-----EREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQAREL 135
                + +++Q+ EE  R     +  A +RQL     A+QR L + + +E+   V++A  L
Sbjct: 2252 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2311

Query: 136  QRQLAEELVNRGHCSRPGASEVSAAQCRCRLQE----VLAQLRWQTDGEQ----AARIRY 187
            + +   EL+ +         E++  Q R RLQE    +  QL  +T G Q    A R R 
Sbjct: 2312 KAE--AELLQQ-------QKELAQEQAR-RLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2361

Query: 188  LQAALEVER 196
            L+ + E ER
Sbjct: 2362 LEMSAEAER 2370



 Score = 44.7 bits (104), Expect = 8e-04
 Identities = 33/122 (27%), Positives = 67/122 (54%), Gaps = 11/122 (9%)

Query: 40   LEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQRER 99
            +E E+A      +   A+ +QLREE +R+++Q+        E +R R +  ++E  +R+ 
Sbjct: 2495 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM--------EQERQRLVASMEEARRRQH 2546

Query: 100  EAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSA 159
            EAE  + +R K+ E +QL+Q   ++ + +  + + L+ QL + L  +   +   + EV+A
Sbjct: 2547 EAE--EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL-QLLEEQHRAALAHSEEVTA 2603

Query: 160  AQ 161
            +Q
Sbjct: 2604 SQ 2605



 Score = 41.2 bits (95), Expect = 0.008
 Identities = 34/125 (27%), Positives = 61/125 (48%), Gaps = 20/125 (16%)

Query: 30   RRELEKLRAELEAERAGWRAERRRFAARER------------QLREEAERERRQLADRLR 77
            R E +  R   +AE  G +  R   A +E+            Q   +AER R  +A+  R
Sbjct: 2384 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2443

Query: 78   SKWEAQRSRELRQLQ-EEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQ 136
             K + Q+  +L QL+ EEMQ  ++ ++ Q       E + LQQ    E+D ++++ R ++
Sbjct: 2444 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQ-------ETQALQQSFLSEKDSLLQRERFIE 2496

Query: 137  RQLAE 141
            ++ A+
Sbjct: 2497 QEKAK 2501



 Score = 40.8 bits (94), Expect = 0.011
 Identities = 88/420 (20%), Positives = 163/420 (38%), Gaps = 63/420 (15%)

Query: 375  KLNWLLAKALWVLARRCYTLQEENK--QLRRAGCPYQADEKVKRLKVKRAELTGLARRLA 432
            +L  L ++ +  ++     ++EE +  + +RA    +  E    L+ +R      A+  A
Sbjct: 1311 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1370

Query: 433  DRARELQETNLRAVSAPIPGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQE 492
               RE +E   R     +  E  A      V A+Q+ R + E+          +++LRQ 
Sbjct: 1371 QAEREAKELQQRMQEEVVRREEAA------VDAQQQKRSIQEE----------LQQLRQS 1414

Query: 493  CHL-LQARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQQGNGG 551
                +QA+      ++                   RL+ E +  V+RLQ +   +Q  GG
Sbjct: 1415 SEAEIQAKARQAEAAER-----------------SRLRIEEEIRVVRLQLEATERQ-RGG 1456

Query: 552  AWPEAGGQSATCEEVRRQMLALERELDQRRRECQELGTQAAPARRRGEEAETQLQAALLK 611
            A  E     A  EE   Q    + E ++ RR+ Q+         +R  +AE +L + +  
Sbjct: 1457 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD-------ESQRKRQAEVELASRVKA 1509

Query: 612  NAWLAEENGR-LQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQLLQQAARGQ-- 668
             A  A E  R LQA  +   +++AE +E R  L +A  ER     +A +  Q++A  +  
Sbjct: 1510 EAEAAREKQRALQALEE--LRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQ 1565

Query: 669  -------DRQQQLQRDPQK---ALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVK 718
                   ++  QL+R  Q+   A+  L    +     Q       E+     ++   Q+K
Sbjct: 1566 SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE--AERELERWQLK 1623

Query: 719  GSRRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKK 778
             +   +   + E+ A  +     + +++    E        A    V +   A Q L K+
Sbjct: 1624 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1683



 Score = 40.4 bits (93), Expect = 0.014
 Identities = 40/140 (28%), Positives = 65/140 (46%), Gaps = 20/140 (14%)

Query: 26   LENQRRELEKLRAELEAERAGWRAER----------RRFAARERQLREEAERERRQLADR 75
            LE  +  L+KLRA+ EA++  + A R           R   R  +   E ER R ++A +
Sbjct: 1111 LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA-Q 1169

Query: 76   LRSKWEA------QRSRELRQLQEEMQREREA--EIRQLLRWKEAEQRQLQQLLHRERDG 127
            L  +W+A       R REL QL  +++  RE+   +   L+     Q Q+Q +   +   
Sbjct: 1170 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1229

Query: 128  VVRQARELQRQLAEELVNRG 147
            V  Q R+ ++ L EE+   G
Sbjct: 1230 VREQLRQ-EQALLEEIERHG 1248



 Score = 39.7 bits (91), Expect = 0.024
 Identities = 42/174 (24%), Positives = 72/174 (41%), Gaps = 7/174 (4%)

Query: 24   AVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQ 83
            A +E  R+    L     +  A  +++R  FA +  QL    + E   +A +LR   EA+
Sbjct: 1541 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA-QLRE--EAE 1597

Query: 84   RSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEEL 143
            R     Q Q E +R RE   R+L RW+      L+  L  E     +   + + +  +E 
Sbjct: 1598 RRA---QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1654

Query: 144  VNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQ 197
              R    R G +E  A + R   ++ L + R   +G    R+   Q  + +  +
Sbjct: 1655 AER-EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE 1707



 Score = 39.7 bits (91), Expect = 0.024
 Identities = 53/186 (28%), Positives = 84/186 (45%), Gaps = 16/186 (8%)

Query: 23   AAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWE- 81
            AA L    +E  +LR   E + A  RA   +    + Q  +EA R + + A+ L+ + E 
Sbjct: 2266 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE-AELLQQQKEL 2324

Query: 82   -AQRSRELRQLQEEMQREREAEIRQLLRWKEAE-QRQLQQLLHRERDGVVRQARELQRQL 139
              +++R L++ +E+M ++   E +   R  EAE QRQL+     ER  +        +  
Sbjct: 2325 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2384

Query: 140  AEELVNRGHCSRPGASEVS--------AAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAA 191
            AEE   R    R  A E+         A Q +  L + L   R Q+D   A R+R   A 
Sbjct: 2385 AEEDAQR---FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD-HDAERLREAIAE 2440

Query: 192  LEVERQ 197
            LE E++
Sbjct: 2441 LEREKE 2446



 Score = 38.5 bits (88), Expect = 0.054
 Identities = 35/136 (25%), Positives = 67/136 (49%), Gaps = 20/136 (14%)

Query: 26   LENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRS 85
            +E ++ +LE+L  +  A+    R E++R   +++Q+ +E +R    + +  R + EA   
Sbjct: 2495 IEQEKAKLEQLFQDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEA--- 2548

Query: 86   RELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVN 145
                   EE  R ++ E++QL    E ++RQ ++LL  E   +  Q + L+ Q    L  
Sbjct: 2549 -------EEGVRRKQEELQQL----EQQRRQQEELLAEENQRLREQLQLLEEQHRAAL-- 2595

Query: 146  RGHCSRPGASEVSAAQ 161
              H     AS+V+A +
Sbjct: 2596 -AHSEEVTASQVAATK 2610



 Score = 37.7 bits (86), Expect = 0.092
 Identities = 38/136 (27%), Positives = 71/136 (52%), Gaps = 16/136 (11%)

Query: 26   LENQRRE----LEKLR---AELEAERAGWRAERRRFAARERQLR----EEAERERRQLAD 74
            LE QR++     E+LR   AELE E+   + E +    +  +++    E+  +E + L  
Sbjct: 2420 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2479

Query: 75   RLRSKWEA--QRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQA 132
               S+ ++  QR R + Q + ++++  + E+ +  + +E +QRQ QQ + +ER  +V   
Sbjct: 2480 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASM 2538

Query: 133  RELQRQL--AEELVNR 146
             E +R+   AEE V R
Sbjct: 2539 EEARRRQHEAEEGVRR 2554



 Score = 36.6 bits (83), Expect = 0.21
 Identities = 55/186 (29%), Positives = 82/186 (44%), Gaps = 23/186 (12%)

Query: 23   AAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERE--RRQLADR--LRS 78
            AA    Q  E E+L+   E E+A  RA+ +   A   +LR+EAE+E  RR  A++  LR 
Sbjct: 2090 AAQSRRQVEEAERLKQSAE-EQAQARAQAQ---AAAEKLRKEAEQEAARRAQAEQAALRQ 2145

Query: 79   KWEAQRSRELRQLQEEMQREREAEIRQ---LLRWKEAEQRQLQQLLHRERDGVVRQAREL 135
            K  A    E  +   E    ++A++ Q    LR +  E    + LL  E   +  +A E 
Sbjct: 2146 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2205

Query: 136  QR---QLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAAL 192
             R   Q+ EEL +     R    E+S  + R   +     LR   D  Q    R+LQ   
Sbjct: 2206 ARQRSQVEEELFS----VRVQMEELSKLKARIEAENRALILR-DKDNTQ----RFLQEEA 2256

Query: 193  EVERQL 198
            E  +Q+
Sbjct: 2257 EKMKQV 2262



 Score = 36.6 bits (83), Expect = 0.21
 Identities = 54/231 (23%), Positives = 100/231 (43%), Gaps = 36/231 (15%)

Query: 413  KVKRLKVKRAELTGL-------ARRLADRARELQETNLRAVSAPIPGESCAGLELCQVFA 465
            + +RLK++ AE++         A+R   +A E+ E   R   A    E    ++  ++  
Sbjct: 2367 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT--QEKVTLVQTLEIQR 2424

Query: 466  RQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPCSDLHTGRGGPCTQWLNVRDL 525
            +Q   D      A    +++ E+L+QE  LLQ +       ++ T +     Q   +++ 
Sbjct: 2425 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLK-----SEEMQTVQ-----QEQLLQET 2474

Query: 526  DRLQRE--SQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRRE 583
              LQ+   S+++ L LQR+  ++Q           + A  +++R +    +++++Q R  
Sbjct: 2475 QALQQSFLSEKDSL-LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER-- 2531

Query: 584  CQELGTQAAPARRRGEEAETQL-----------QAALLKNAWLAEENGRLQ 623
             Q L      ARRR  EAE  +           Q    +   LAEEN RL+
Sbjct: 2532 -QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2581



 Score = 33.1 bits (74), Expect = 2.3
 Identities = 34/121 (28%), Positives = 52/121 (42%), Gaps = 12/121 (9%)

Query: 22   AAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLR------EEAERERRQLADR 75
            A  + E Q+R+ +++  E +   A     RRR    E  +R      ++ E++RRQ  + 
Sbjct: 2513 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2572

Query: 76   LRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQAREL 135
            L    E QR RE  QL EE  R   A   ++     A Q    + L   RD +   A E 
Sbjct: 2573 LAE--ENQRLREQLQLLEEQHRAALAHSEEV----TASQVAATKTLPNGRDALDGPAAEA 2626

Query: 136  Q 136
            +
Sbjct: 2627 E 2627


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 203/881 (23%), Positives = 333/881 (37%), Gaps = 164/881 (18%)

Query: 25   VLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQ------------- 71
            V+  Q    E+ R   E E    RA      A++RQ +EEAER RRQ             
Sbjct: 1483 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1542

Query: 72   -LADRLRSKWEAQRSR--------ELR-QLQEEMQREREAEI---RQLLRWKEAEQRQLQ 118
             LA R++++ EA R +        ELR Q +E  +R R+AE+   RQ+    E  QR  +
Sbjct: 1543 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1602

Query: 119  QLLHRERDGVVRQARELQRQLAEELVN----RGHCSRPGASEVSAAQCRCRLQEVLAQLR 174
              L  +R     +  +L+R L EE V     R    R    +  A + R   +  L   R
Sbjct: 1603 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE--R 1660

Query: 175  WQTDGEQAARIRYLQAALEVERQLFLKYILAHFRGHPA-----LSGSPDPQAVHSLE--- 226
            WQ    +A R+R LQA  EV +Q  L    A  +   A       G  + QAV   E   
Sbjct: 1661 WQLKANEALRLR-LQAE-EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1718

Query: 227  ---EPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVRSRSL------GLVSSACSSSP--- 274
               E   Q + G+      A Q         E G + R L       L   A +++    
Sbjct: 1719 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1778

Query: 275  --DGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSPDTSTPGSRRLSPPPSPL 332
              +  L+   + ++    + +R+ + +RS  + SK        +      R L+   + L
Sbjct: 1779 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR-----LEAEAGRFRELAEEAARL 1833

Query: 333  PPPPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHHELIKLNWLLA-KALWVLARRC 391
                  +  ++           ++   VL      +G    +K    +A K       R 
Sbjct: 1834 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1893

Query: 392  YTLQE----ENKQLRRAGCPYQADEKVKRLKVKRAELTGLARR---LADRARELQETNLR 444
              L E    + ++L      ++AD + +  ++++A  + L R+   + D  R+ ++    
Sbjct: 1894 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1953

Query: 445  AVSAPIPGESCAG----LELCQVFARQRARDL---SEQASAPLAKDKQI----EELRQEC 493
             ++     E  A     LEL     R  A D     EQA    A+ +Q+    E  R+E 
Sbjct: 1954 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 2013

Query: 494  HLLQARVASGPCSDLHTGRGGPCTQWLNVRDLDRL-------QRESQREVLRLQRQLMLQ 546
               + RV     ++    R         + +++RL       +R  +R      RQL L 
Sbjct: 2014 ---EERVQKSLAAEEEAARQRKAA----LEEVERLKAKVEEARRLRERAEQESARQLQLA 2066

Query: 547  QGNGGAWPEAGGQSATCEE------VRRQMLALERELDQRRRECQELGTQAAPARRRGEE 600
            Q       EA  +    EE      V+++   L++ L Q +    +L  +A  ARR  EE
Sbjct: 2067 Q-------EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2119

Query: 601  AE--------------------------TQLQAALLKNAWLAEENGRLQAKTDWVRKVEA 634
            AE                           + QA     A  A E  R +A+ +  R+ +A
Sbjct: 2120 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2179

Query: 635  ENSEVRGHLGRACQERDASGLIAEQLLQQAARGQD-----RQQQLQRDPQKALCDLHPSW 689
            E + +R     A  E +     AEQ L+Q A+ +      R Q  + D QK L D     
Sbjct: 2180 EQAALR-QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD----- 2233

Query: 690  KEIQALQCRPGHPPEQPWETSQMPES------QVKGSRRPKFHARPEDYAVSQPNRD--- 740
            +E+Q L+       E   + SQ+ E       Q++   + K     E+ A+   ++D   
Sbjct: 2234 EELQRLK---AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2290

Query: 741  --IQEKREASLEES------PVALGESASVPQVSETVPASQ 773
              +QE+ E   + +       VA  E+A + Q++E   A Q
Sbjct: 2291 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2331



 Score = 57.8 bits (138), Expect = 9e-08
 Identities = 177/803 (22%), Positives = 310/803 (38%), Gaps = 77/803 (9%)

Query: 34   EKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELRQLQE 93
            E LR   E ER    AE++R   RER    EA  E+++      ++ +AQ  RE ++LQ+
Sbjct: 1366 ETLRRMEEEERL---AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1422

Query: 94   EMQRE---RE---AEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQR---QLAEE-- 142
             MQ E   RE    + +Q  R  + E +QL+Q    E     RQA   +R   ++ EE  
Sbjct: 1423 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1482

Query: 143  ---LVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQLF 199
               L       + G +E      R R +E  AQ R     E+A R+R  Q   E +R+  
Sbjct: 1483 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ--EEAERLR-RQVQDESQRKRQ 1539

Query: 200  LKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVR 259
             +  LA      A +     +A+ +LEE   Q         +   +      ++ E   R
Sbjct: 1540 AEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR 1599

Query: 260  SRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSP---- 315
            S    L S   S +        +   +  A A  R     R+  +A     R  +     
Sbjct: 1600 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1659

Query: 316  ----DTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHH 371
                  +     RL             +   K       E       E        L   
Sbjct: 1660 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1719

Query: 372  ELIKLNWL--------LAKALWVLARRCYTLQ-EENKQL---------RRAGCPYQADEK 413
            EL K   L        LA    ++  R  T Q E+ +QL         R A    Q  ++
Sbjct: 1720 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1779

Query: 414  VK-RLKVKRAELTGLARRLADRARELQETNLRAVSAPIPGESCAG--LELCQVFARQRAR 470
            ++  L   RAE+  L   LA +AR  +E+   +  +    E+ AG   EL +  AR RA 
Sbjct: 1780 LEAELAKVRAEMEVL---LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1836

Query: 471  DLSEQASAPLAKDKQIEELRQECHLLQARVAS-GPCSDLHTGRGGPCTQWLNVRDLDRLQ 529
                +    LA++    +  +   +L  ++A+ G  + L T       +     + +RL+
Sbjct: 1837 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE--KEAENERLR 1894

Query: 530  RESQREVLRLQRQLMLQQGNGGAWPE---AGGQSATCEEVRRQMLALERELDQRRRECQE 586
            R ++ E  + +R+L  Q     A  E   A  + A+  E+ RQ   +E  L QRR+  +E
Sbjct: 1895 RLAEDEAFQ-RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1953

Query: 587  -LGTQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGR 645
             L  +A+  +    +AE +L+   +++        + QA+ +  R+ +    E R    R
Sbjct: 1954 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR--R 2011

Query: 646  ACQERDASGLIAEQLLQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQ 705
              +ER    L AE+  + A + +   ++++R        L    +E + L+ R      +
Sbjct: 2012 EAEERVQKSLAAEE--EAARQRKAALEEVER--------LKAKVEEARRLRER-----AE 2056

Query: 706  PWETSQMPESQVKGSRRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQV 765
                 Q+  +Q    +R +   +   +AV Q  +++Q+  +          GE+ +  + 
Sbjct: 2057 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2116

Query: 766  SETVPASQPLSKKTSSQSNSSSE 788
            +E    ++  +++ ++QS    E
Sbjct: 2117 AEEAEEARVQAEREAAQSRRQVE 2139



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 59/188 (31%), Positives = 89/188 (47%), Gaps = 24/188 (12%)

Query: 23   AAVLENQRRELE-KLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWE 81
            AA  E +RRE E +++  L AE     A R+R AA E   R +A+ E    A RLR + E
Sbjct: 2003 AAEEERRRREAEERVQKSLAAEE---EAARQRKAALEEVERLKAKVEE---ARRLRERAE 2056

Query: 82   AQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGV--VRQARELQRQL 139
             + +R+L+  QE  Q+  +AE +      + ++++LQQ L +E+  +  +R   E  R+ 
Sbjct: 2057 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2116

Query: 140  AEELVN-RGHCSRPGA--------------SEVSAAQCRCRLQEVLAQLRWQTDGEQAAR 184
            AEE    R    R  A              S    AQ R + Q    +LR + + E A R
Sbjct: 2117 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2176

Query: 185  IRYLQAAL 192
             +  QAAL
Sbjct: 2177 AQAEQAAL 2184



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 52/191 (27%), Positives = 96/191 (50%), Gaps = 23/191 (12%)

Query: 24   AVLENQRRELEKLR-AELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEA 82
            +VL+  R E E  R A  EAE A  +AER   AA+ R+  EEAER ++   ++ +++ +A
Sbjct: 2101 SVLDQLRGEAEAARRAAEEAEEARVQAERE--AAQSRRQVEEAERLKQSAEEQAQARAQA 2158

Query: 83   QRSRELRQLQEEMQREREAEIRQ-LLRWKEAEQRQLQQLLHRE-RDGVVRQARELQRQLA 140
            Q + E  + + E +  R A+  Q  LR K+A   ++++  H++  +  +RQ  +++++L 
Sbjct: 2159 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK--HKKFAEQTLRQKAQVEQELT 2216

Query: 141  E---ELVNRGH--------CSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQ 189
                +L    H          R  A    AA+ R +++E L  +R Q +      +  L+
Sbjct: 2217 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME-----ELSKLK 2271

Query: 190  AALEVERQLFL 200
            A +E E +  +
Sbjct: 2272 ARIEAENRALI 2282



 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 56/186 (30%), Positives = 89/186 (47%), Gaps = 20/186 (10%)

Query: 29   QRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSREL 88
            Q  EL KL+A +EAE        +     +R L+EEAE+ ++   +  R    AQ +  L
Sbjct: 2263 QMEELSKLKARIEAENRALILRDKDNT--QRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2320

Query: 89   RQLQEEMQREREAEIRQLLRWK-----EAEQRQLQ-QLLHRERDGVVRQARELQ------ 136
            RQL EE   ++ A   ++L+ K     EA + + + +LL ++++    QAR LQ      
Sbjct: 2321 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2380

Query: 137  -RQLAEE---LVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAAL 192
             +QLAEE           R    E+SA   R +L+ V    R Q   E+ A+ R+ + A 
Sbjct: 2381 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR-VAEMSRAQARAEEDAQ-RFRKQAE 2438

Query: 193  EVERQL 198
            E+  +L
Sbjct: 2439 EIGEKL 2444



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 56/204 (27%), Positives = 81/204 (39%), Gaps = 46/204 (22%)

Query: 24   AVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQ 83
            A L+ +     + R ELEAE A  RAE     A     +  AE E R  +++ + + EA+
Sbjct: 1764 ARLQREAAAATQKRQELEAELAKVRAEMEVLLAS----KARAEEESRSTSEKSKQRLEAE 1819

Query: 84   RSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEEL 143
              R  R+L EE  R R       L  +   QRQL +      +   RQ  E +R LAE+L
Sbjct: 1820 AGR-FRELAEEAARLR------ALAEEAKRQRQLAE------EDAARQRAEAERVLAEKL 1866

Query: 144  VNRGHCSRPGAS-----------------------------EVSAAQCRCRLQEVLAQLR 174
               G  +R                                 E  AAQ +  ++E LAQLR
Sbjct: 1867 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1926

Query: 175  WQTDGEQAARIRYLQAALEVERQL 198
              +D E   +   ++  L   RQ+
Sbjct: 1927 KASDSELERQKGLVEDTLRQRRQV 1950



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 58/189 (30%), Positives = 90/189 (47%), Gaps = 36/189 (19%)

Query: 32   ELEKLRAEL-EAERAGWRAERRRFAARER-----QLREEAERERRQLADRLRSKWEAQR- 84
            EL++L+AE  EA R   + E   F+ R +     +L+   E E R L   LR K   QR 
Sbjct: 2235 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI--LRDKDNTQRF 2292

Query: 85   ----SRELRQLQEEMQR-----EREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQAREL 135
                + +++Q+ EE  R     +  A +RQL     A+QR L + + +E+   V++A  L
Sbjct: 2293 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2352

Query: 136  QRQLAEELVNRGHCSRPGASEVSAAQCRCRLQE----VLAQLRWQTDGEQ----AARIRY 187
            + +   EL+ +         E++  Q R RLQE    +  QL  +T G Q    A R R 
Sbjct: 2353 KAE--AELLQQ-------QKELAQEQAR-RLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2402

Query: 188  LQAALEVER 196
            L+ + E ER
Sbjct: 2403 LEMSAEAER 2411



 Score = 44.7 bits (104), Expect = 8e-04
 Identities = 33/122 (27%), Positives = 67/122 (54%), Gaps = 11/122 (9%)

Query: 40   LEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQRER 99
            +E E+A      +   A+ +QLREE +R+++Q+        E +R R +  ++E  +R+ 
Sbjct: 2536 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM--------EQERQRLVASMEEARRRQH 2587

Query: 100  EAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSA 159
            EAE  + +R K+ E +QL+Q   ++ + +  + + L+ QL + L  +   +   + EV+A
Sbjct: 2588 EAE--EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL-QLLEEQHRAALAHSEEVTA 2644

Query: 160  AQ 161
            +Q
Sbjct: 2645 SQ 2646



 Score = 41.2 bits (95), Expect = 0.008
 Identities = 34/125 (27%), Positives = 61/125 (48%), Gaps = 20/125 (16%)

Query: 30   RRELEKLRAELEAERAGWRAERRRFAARER------------QLREEAERERRQLADRLR 77
            R E +  R   +AE  G +  R   A +E+            Q   +AER R  +A+  R
Sbjct: 2425 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2484

Query: 78   SKWEAQRSRELRQLQ-EEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQ 136
             K + Q+  +L QL+ EEMQ  ++ ++ Q       E + LQQ    E+D ++++ R ++
Sbjct: 2485 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQ-------ETQALQQSFLSEKDSLLQRERFIE 2537

Query: 137  RQLAE 141
            ++ A+
Sbjct: 2538 QEKAK 2542



 Score = 40.8 bits (94), Expect = 0.011
 Identities = 88/420 (20%), Positives = 163/420 (38%), Gaps = 63/420 (15%)

Query: 375  KLNWLLAKALWVLARRCYTLQEENK--QLRRAGCPYQADEKVKRLKVKRAELTGLARRLA 432
            +L  L ++ +  ++     ++EE +  + +RA    +  E    L+ +R      A+  A
Sbjct: 1352 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1411

Query: 433  DRARELQETNLRAVSAPIPGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQE 492
               RE +E   R     +  E  A      V A+Q+ R + E+          +++LRQ 
Sbjct: 1412 QAEREAKELQQRMQEEVVRREEAA------VDAQQQKRSIQEE----------LQQLRQS 1455

Query: 493  CHL-LQARVASGPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQQGNGG 551
                +QA+      ++                   RL+ E +  V+RLQ +   +Q  GG
Sbjct: 1456 SEAEIQAKARQAEAAER-----------------SRLRIEEEIRVVRLQLEATERQ-RGG 1497

Query: 552  AWPEAGGQSATCEEVRRQMLALERELDQRRRECQELGTQAAPARRRGEEAETQLQAALLK 611
            A  E     A  EE   Q    + E ++ RR+ Q+         +R  +AE +L + +  
Sbjct: 1498 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD-------ESQRKRQAEVELASRVKA 1550

Query: 612  NAWLAEENGR-LQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQLLQQAARGQ-- 668
             A  A E  R LQA  +   +++AE +E R  L +A  ER     +A +  Q++A  +  
Sbjct: 1551 EAEAAREKQRALQALEE--LRLQAEEAERR--LRQAEVERARQVQVALETAQRSAEAELQ 1606

Query: 669  -------DRQQQLQRDPQK---ALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVK 718
                   ++  QL+R  Q+   A+  L    +     Q       E+     ++   Q+K
Sbjct: 1607 SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE--AERELERWQLK 1664

Query: 719  GSRRPKFHARPEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKK 778
             +   +   + E+ A  +     + +++    E        A    V +   A Q L K+
Sbjct: 1665 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ 1724



 Score = 40.4 bits (93), Expect = 0.014
 Identities = 40/140 (28%), Positives = 65/140 (46%), Gaps = 20/140 (14%)

Query: 26   LENQRRELEKLRAELEAERAGWRAER----------RRFAARERQLREEAERERRQLADR 75
            LE  +  L+KLRA+ EA++  + A R           R   R  +   E ER R ++A +
Sbjct: 1152 LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA-Q 1210

Query: 76   LRSKWEA------QRSRELRQLQEEMQREREA--EIRQLLRWKEAEQRQLQQLLHRERDG 127
            L  +W+A       R REL QL  +++  RE+   +   L+     Q Q+Q +   +   
Sbjct: 1211 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1270

Query: 128  VVRQARELQRQLAEELVNRG 147
            V  Q R+ ++ L EE+   G
Sbjct: 1271 VREQLRQ-EQALLEEIERHG 1289



 Score = 39.7 bits (91), Expect = 0.024
 Identities = 42/174 (24%), Positives = 72/174 (41%), Gaps = 7/174 (4%)

Query: 24   AVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQ 83
            A +E  R+    L     +  A  +++R  FA +  QL    + E   +A +LR   EA+
Sbjct: 1582 AEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVA-QLRE--EAE 1638

Query: 84   RSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEEL 143
            R     Q Q E +R RE   R+L RW+      L+  L  E     +   + + +  +E 
Sbjct: 1639 RRA---QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1695

Query: 144  VNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQ 197
              R    R G +E  A + R   ++ L + R   +G    R+   Q  + +  +
Sbjct: 1696 AER-EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE 1748



 Score = 39.7 bits (91), Expect = 0.024
 Identities = 53/186 (28%), Positives = 84/186 (45%), Gaps = 16/186 (8%)

Query: 23   AAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWE- 81
            AA L    +E  +LR   E + A  RA   +    + Q  +EA R + + A+ L+ + E 
Sbjct: 2307 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE-AELLQQQKEL 2365

Query: 82   -AQRSRELRQLQEEMQREREAEIRQLLRWKEAE-QRQLQQLLHRERDGVVRQARELQRQL 139
              +++R L++ +E+M ++   E +   R  EAE QRQL+     ER  +        +  
Sbjct: 2366 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2425

Query: 140  AEELVNRGHCSRPGASEVS--------AAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAA 191
            AEE   R    R  A E+         A Q +  L + L   R Q+D   A R+R   A 
Sbjct: 2426 AEEDAQR---FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD-HDAERLREAIAE 2481

Query: 192  LEVERQ 197
            LE E++
Sbjct: 2482 LEREKE 2487



 Score = 38.5 bits (88), Expect = 0.054
 Identities = 35/136 (25%), Positives = 67/136 (49%), Gaps = 20/136 (14%)

Query: 26   LENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRS 85
            +E ++ +LE+L  +  A+    R E++R   +++Q+ +E +R    + +  R + EA   
Sbjct: 2536 IEQEKAKLEQLFQDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEA--- 2589

Query: 86   RELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVN 145
                   EE  R ++ E++QL    E ++RQ ++LL  E   +  Q + L+ Q    L  
Sbjct: 2590 -------EEGVRRKQEELQQL----EQQRRQQEELLAEENQRLREQLQLLEEQHRAAL-- 2636

Query: 146  RGHCSRPGASEVSAAQ 161
              H     AS+V+A +
Sbjct: 2637 -AHSEEVTASQVAATK 2651



 Score = 37.7 bits (86), Expect = 0.092
 Identities = 38/136 (27%), Positives = 71/136 (52%), Gaps = 16/136 (11%)

Query: 26   LENQRRE----LEKLR---AELEAERAGWRAERRRFAARERQLR----EEAERERRQLAD 74
            LE QR++     E+LR   AELE E+   + E +    +  +++    E+  +E + L  
Sbjct: 2461 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2520

Query: 75   RLRSKWEA--QRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQA 132
               S+ ++  QR R + Q + ++++  + E+ +  + +E +QRQ QQ + +ER  +V   
Sbjct: 2521 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ-QQQMEQERQRLVASM 2579

Query: 133  RELQRQL--AEELVNR 146
             E +R+   AEE V R
Sbjct: 2580 EEARRRQHEAEEGVRR 2595



 Score = 36.6 bits (83), Expect = 0.21
 Identities = 55/186 (29%), Positives = 82/186 (44%), Gaps = 23/186 (12%)

Query: 23   AAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERE--RRQLADR--LRS 78
            AA    Q  E E+L+   E E+A  RA+ +   A   +LR+EAE+E  RR  A++  LR 
Sbjct: 2131 AAQSRRQVEEAERLKQSAE-EQAQARAQAQ---AAAEKLRKEAEQEAARRAQAEQAALRQ 2186

Query: 79   KWEAQRSRELRQLQEEMQREREAEIRQ---LLRWKEAEQRQLQQLLHRERDGVVRQAREL 135
            K  A    E  +   E    ++A++ Q    LR +  E    + LL  E   +  +A E 
Sbjct: 2187 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2246

Query: 136  QR---QLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAAL 192
             R   Q+ EEL +     R    E+S  + R   +     LR   D  Q    R+LQ   
Sbjct: 2247 ARQRSQVEEELFS----VRVQMEELSKLKARIEAENRALILR-DKDNTQ----RFLQEEA 2297

Query: 193  EVERQL 198
            E  +Q+
Sbjct: 2298 EKMKQV 2303



 Score = 36.6 bits (83), Expect = 0.21
 Identities = 54/231 (23%), Positives = 100/231 (43%), Gaps = 36/231 (15%)

Query: 413  KVKRLKVKRAELTGL-------ARRLADRARELQETNLRAVSAPIPGESCAGLELCQVFA 465
            + +RLK++ AE++         A+R   +A E+ E   R   A    E    ++  ++  
Sbjct: 2408 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT--QEKVTLVQTLEIQR 2465

Query: 466  RQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPCSDLHTGRGGPCTQWLNVRDL 525
            +Q   D      A    +++ E+L+QE  LLQ +       ++ T +     Q   +++ 
Sbjct: 2466 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLK-----SEEMQTVQ-----QEQLLQET 2515

Query: 526  DRLQRE--SQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRRE 583
              LQ+   S+++ L LQR+  ++Q           + A  +++R +    +++++Q R  
Sbjct: 2516 QALQQSFLSEKDSL-LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER-- 2572

Query: 584  CQELGTQAAPARRRGEEAETQL-----------QAALLKNAWLAEENGRLQ 623
             Q L      ARRR  EAE  +           Q    +   LAEEN RL+
Sbjct: 2573 -QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2622



 Score = 33.1 bits (74), Expect = 2.3
 Identities = 34/121 (28%), Positives = 52/121 (42%), Gaps = 12/121 (9%)

Query: 22   AAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLR------EEAERERRQLADR 75
            A  + E Q+R+ +++  E +   A     RRR    E  +R      ++ E++RRQ  + 
Sbjct: 2554 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2613

Query: 76   LRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQAREL 135
            L    E QR RE  QL EE  R   A   ++     A Q    + L   RD +   A E 
Sbjct: 2614 LAE--ENQRLREQLQLLEEQHRAALAHSEEV----TASQVAATKTLPNGRDALDGPAAEA 2667

Query: 136  Q 136
            +
Sbjct: 2668 E 2668


>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 1 [Homo sapiens]
          Length = 1166

 Score = 72.0 bits (175), Expect = 4e-12
 Identities = 97/337 (28%), Positives = 144/337 (42%), Gaps = 47/337 (13%)

Query: 30  RRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELR 89
           RR+  +L+ E   ER+   A RR+   +E+QLRE+ E +R+ LA+  R K   Q+  + R
Sbjct: 353 RRDFLRLQQE-NKERS--EALRRQQLLQEQQLREQEEYKRQLLAE--RQKRIEQQKEQRR 407

Query: 90  QLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVNRGHC 149
           +L+E+ +REREA      R +E EQR+ +Q    E+    R+  EL+R+  EE   R   
Sbjct: 408 RLEEQQRREREAR-----RQQEREQRRREQ---EEK----RRLEELERRRKEEEERR--- 452

Query: 150 SRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQLFLKYILAHFRG 209
                    A + + R++     +R Q + EQ   +  LQ  L  E+ + L     H R 
Sbjct: 453 --------RAEEEKRRVEREQEYIRRQLEEEQ-RHLEVLQQQLLQEQAMLLH---DHRRP 500

Query: 210 HPALSGSPDPQAVHSLEEPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVRSRSLGLVSSA 269
           HP  S  P P        P  + S  S HAP+P       D  + EV VR+ S   V S 
Sbjct: 501 HPQHSQQPPP--------PQQERSKPSFHAPEPKAHYEPADR-AREVPVRTTSRSPVLSR 551

Query: 270 CSSSPDGLLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSPDTSTPGSRRLSPPP 329
             S   G   +   +        + S++      +  K   RP S  +S  GS      P
Sbjct: 552 RDSPLQG---SGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSS--GSSNSGSQP 606

Query: 330 SPLPPPPPPSAHR-KLSNPRGGEGSESQPCEVLTPSP 365
              P     S  R ++ +    EGS SQ  E     P
Sbjct: 607 GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKP 643



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 40/104 (38%), Positives = 57/104 (54%), Gaps = 13/104 (12%)

Query: 27  ENQRREL-EKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRS 85
           + QRR L E+ R E EA R   R +RRR    +R+L EE ER R++  +R R++   +  
Sbjct: 403 KEQRRRLEEQQRREREARRQQEREQRRREQEEKRRL-EELERRRKEEEERRRAE---EEK 458

Query: 86  RELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQ----LLHRER 125
           R + + QE ++R+ E E R L    E  Q+QL Q    LLH  R
Sbjct: 459 RRVEREQEYIRRQLEEEQRHL----EVLQQQLLQEQAMLLHDHR 498



 Score = 38.9 bits (89), Expect = 0.041
 Identities = 79/310 (25%), Positives = 117/310 (37%), Gaps = 102/310 (32%)

Query: 523 RDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLA---------- 572
           RD  RLQ+E++     L+RQ +LQ+           Q    EE +RQ+LA          
Sbjct: 354 RDFLRLQQENKERSEALRRQQLLQEQ----------QLREQEEYKRQLLAERQKRIEQQK 403

Query: 573 -----------------LERELDQRRRECQELGTQAAPARRRGEEAETQLQAALLKNAWL 615
                             ++E +QRRRE +E        +RR EE E + +         
Sbjct: 404 EQRRRLEEQQRREREARRQQEREQRRREQEE--------KRRLEELERRRK--------- 446

Query: 616 AEENGRLQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQLLQQAARGQDRQQQLQ 675
            EE  R +A+ +  R+VE E   +R  L    +E+    ++ +QLLQ+       Q  L 
Sbjct: 447 -EEEERRRAEEE-KRRVEREQEYIRRQLE---EEQRHLEVLQQQLLQE-------QAMLL 494

Query: 676 RDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKGSRRPKFHARPEDYAVS 735
            D ++     HP     Q  Q  P    E+   +   PE        PK H  P D A  
Sbjct: 495 HDHRRP----HP-----QHSQQPPPPQQERSKPSFHAPE--------PKAHYEPADRARE 537

Query: 736 QPNRDIQEKREASLEESPV--------ALGESASV---------PQVSETVPASQPLSKK 778
            P R        S  +SP+          G+  S           +V + VP  +P S  
Sbjct: 538 VPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVP--RPGSGS 595

Query: 779 TSSQSNSSSE 788
           +S  SNS S+
Sbjct: 596 SSGSSNSGSQ 605


>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 3 [Homo sapiens]
          Length = 1212

 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 91/305 (29%), Positives = 135/305 (44%), Gaps = 49/305 (16%)

Query: 30  RRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELR 89
           RR+  +L+ E   ER+   A RR+   +E+QLRE+ E +R+ LA+  R K   Q+  + R
Sbjct: 353 RRDFLRLQQE-NKERS--EALRRQQLLQEQQLREQEEYKRQLLAE--RQKRIEQQKEQRR 407

Query: 90  QLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVNRGHC 149
           +L+E+ +REREA      R +E EQR+ +Q    E+    R+  EL+R+  EE   R   
Sbjct: 408 RLEEQQRREREAR-----RQQEREQRRREQ---EEK----RRLEELERRRKEEEERR--- 452

Query: 150 SRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQLFLKYILAHFRG 209
                    A + + R++     +R Q + EQ   +  LQ  L  E+ + L     H R 
Sbjct: 453 --------RAEEEKRRVEREQEYIRRQLEEEQ-RHLEVLQQQLLQEQAMLLH---DHRRP 500

Query: 210 HPALSGSPDPQAVHSLEEPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVRSRSLGLVSSA 269
           HP  S  P P        P  + S  S HAP+P       D  + EV  R R        
Sbjct: 501 HPQHSQQPPP--------PQQERSKPSFHAPEPKAHYEPADR-AREVEDRFRKTN----- 546

Query: 270 CSSSPDGLLSTHASSLDCFAPACSRSLD--STRSLPKASKSEERPSSPDTSTPGSRRLSP 327
             SSP+         L+   P+ S S    ++ S+  A +    P  P  +T  S  LS 
Sbjct: 547 -HSSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVHPALQRPAEPQVPVRTTSRSPVLSR 605

Query: 328 PPSPL 332
             SPL
Sbjct: 606 RDSPL 610



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 40/104 (38%), Positives = 57/104 (54%), Gaps = 13/104 (12%)

Query: 27  ENQRREL-EKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRS 85
           + QRR L E+ R E EA R   R +RRR    +R+L EE ER R++  +R R++   +  
Sbjct: 403 KEQRRRLEEQQRREREARRQQEREQRRREQEEKRRL-EELERRRKEEEERRRAE---EEK 458

Query: 86  RELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQ----LLHRER 125
           R + + QE ++R+ E E R L    E  Q+QL Q    LLH  R
Sbjct: 459 RRVEREQEYIRRQLEEEQRHL----EVLQQQLLQEQAMLLHDHR 498



 Score = 41.2 bits (95), Expect = 0.008
 Identities = 74/296 (25%), Positives = 118/296 (39%), Gaps = 101/296 (34%)

Query: 523 RDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLA---------- 572
           RD  RLQ+E++     L+RQ +LQ+           Q    EE +RQ+LA          
Sbjct: 354 RDFLRLQQENKERSEALRRQQLLQEQ----------QLREQEEYKRQLLAERQKRIEQQK 403

Query: 573 -----------------LERELDQRRRECQELGTQAAPARRRGEEAETQLQAALLKNAWL 615
                             ++E +QRRRE +E        +RR EE E + +         
Sbjct: 404 EQRRRLEEQQRREREARRQQEREQRRREQEE--------KRRLEELERRRK--------- 446

Query: 616 AEENGRLQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQLLQQAARGQDRQQQLQ 675
            EE  R +A+ +  R+VE E   +R  L    +E+    ++ +QLLQ+       Q  L 
Sbjct: 447 -EEEERRRAEEE-KRRVEREQEYIRRQLE---EEQRHLEVLQQQLLQE-------QAMLL 494

Query: 676 RDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKGSRRPKFHARPEDYAVS 735
            D ++     HP                    + SQ P    +   +P FHA PE  A  
Sbjct: 495 HDHRRP----HP--------------------QHSQQPPPPQQERSKPSFHA-PEPKAHY 529

Query: 736 QP---NRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTSSQSNSSSE 788
           +P    R+++++   +   SP A  +S    +V E      P+  ++ S SN +SE
Sbjct: 530 EPADRAREVEDRFRKTNHSSPEA--QSKQTGRVLE-----PPVPSRSESFSNGNSE 578


>gi|56549694 enabled homolog isoform a [Homo sapiens]
          Length = 591

 Score = 62.0 bits (149), Expect = 5e-09
 Identities = 57/168 (33%), Positives = 83/168 (49%), Gaps = 9/168 (5%)

Query: 19  SSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRS 78
           + P+   LE QRR+L++ + + E ER   R ER R   RER  RE  ERER +  +RL  
Sbjct: 133 NGPSQEELEIQRRQLQEQQRQKELERE--RLERERM-ERERLERERLERERLE-RERLEQ 188

Query: 79  KWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVV---RQAREL 135
           + + +R R+ R+ QE ++R+   E ++ L  +E   R+ Q+   RER   +   RQ RE 
Sbjct: 189 E-QLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERER 247

Query: 136 QRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAA 183
           Q QL  E +      R  +S  + A     L  VL        G QAA
Sbjct: 248 QEQLEREQL-EWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAA 294



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 76/278 (27%), Positives = 111/278 (39%), Gaps = 49/278 (17%)

Query: 62  REEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQ-QL 120
           +EE E +RRQL ++ R K E +R R  R+  E  + ERE   R+ L  +  EQ QL+ + 
Sbjct: 137 QEELEIQRRQLQEQQRQK-ELERERLERERMERERLERERLERERLERERLEQEQLERER 195

Query: 121 LHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGE 180
             RER   + +   L+RQ  E L  +    R    E    Q R RL+ +  + + +   E
Sbjct: 196 QERERQERLERQERLERQ--ERLERQERLDR----ERQERQERERLERLERERQERERQE 249

Query: 181 QAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAP 240
           Q  R +     LE ER+  +    A     PA           S+E PL  +  G   A 
Sbjct: 250 QLEREQ-----LEWERERRISSAAA-----PA-----------SVETPL-NSVLGDSSAS 287

Query: 241 KPACQLGSLDSLSAEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTR 300
           +P  Q  S  + +          G+V    +  P   L           PA      ++ 
Sbjct: 288 EPGLQAASQPAETPS------QQGIVLGPLAPPPPPPLPP--------GPA-----QASV 328

Query: 301 SLPKASKSEERPSSPDTSTPGSRRLSPPPSPLPPPPPP 338
           +LP        P  P T  P      P P+ +PPPPPP
Sbjct: 329 ALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQVPPPPPP 366



 Score = 33.5 bits (75), Expect = 1.7
 Identities = 31/118 (26%), Positives = 41/118 (34%)

Query: 249 LDSLSAEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTRSLPKASKS 308
           L+ L  E   R R   L         +  +S+ A+      P  S   DS+ S P    +
Sbjct: 235 LERLERERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAA 294

Query: 309 EERPSSPDTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEVLTPSPP 366
            +   +P         L+PPP P  PP P  A   L  P G       P     P PP
Sbjct: 295 SQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPSTGPPPPPP 352


>gi|39930375 enabled homolog isoform b [Homo sapiens]
          Length = 570

 Score = 62.0 bits (149), Expect = 5e-09
 Identities = 57/168 (33%), Positives = 83/168 (49%), Gaps = 9/168 (5%)

Query: 19  SSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRS 78
           + P+   LE QRR+L++ + + E ER   R ER R   RER  RE  ERER +  +RL  
Sbjct: 133 NGPSQEELEIQRRQLQEQQRQKELERE--RLERERM-ERERLERERLERERLE-RERLEQ 188

Query: 79  KWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVV---RQAREL 135
           + + +R R+ R+ QE ++R+   E ++ L  +E   R+ Q+   RER   +   RQ RE 
Sbjct: 189 E-QLERERQERERQERLERQERLERQERLERQERLDRERQERQERERLERLERERQERER 247

Query: 136 QRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAA 183
           Q QL  E +      R  +S  + A     L  VL        G QAA
Sbjct: 248 QEQLEREQL-EWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAA 294



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 76/278 (27%), Positives = 111/278 (39%), Gaps = 49/278 (17%)

Query: 62  REEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQ-QL 120
           +EE E +RRQL ++ R K E +R R  R+  E  + ERE   R+ L  +  EQ QL+ + 
Sbjct: 137 QEELEIQRRQLQEQQRQK-ELERERLERERMERERLERERLERERLERERLEQEQLERER 195

Query: 121 LHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGE 180
             RER   + +   L+RQ  E L  +    R    E    Q R RL+ +  + + +   E
Sbjct: 196 QERERQERLERQERLERQ--ERLERQERLDR----ERQERQERERLERLERERQERERQE 249

Query: 181 QAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPDPQAVHSLEEPLPQTSSGSCHAP 240
           Q  R +     LE ER+  +    A     PA           S+E PL  +  G   A 
Sbjct: 250 QLEREQ-----LEWERERRISSAAA-----PA-----------SVETPL-NSVLGDSSAS 287

Query: 241 KPACQLGSLDSLSAEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTR 300
           +P  Q  S  + +          G+V    +  P   L           PA      ++ 
Sbjct: 288 EPGLQAASQPAETPS------QQGIVLGPLAPPPPPPLPP--------GPA-----QASV 328

Query: 301 SLPKASKSEERPSSPDTSTPGSRRLSPPPSPLPPPPPP 338
           +LP        P  P T  P      P P+ +PPPPPP
Sbjct: 329 ALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQVPPPPPP 366



 Score = 33.5 bits (75), Expect = 1.7
 Identities = 31/118 (26%), Positives = 41/118 (34%)

Query: 249 LDSLSAEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRSLDSTRSLPKASKS 308
           L+ L  E   R R   L         +  +S+ A+      P  S   DS+ S P    +
Sbjct: 235 LERLERERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAA 294

Query: 309 EERPSSPDTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSESQPCEVLTPSPP 366
            +   +P         L+PPP P  PP P  A   L  P G       P     P PP
Sbjct: 295 SQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPSTGPPPPPP 352


>gi|157502225 Janus kinase and microtubule interacting protein 3
           [Homo sapiens]
          Length = 844

 Score = 61.6 bits (148), Expect = 6e-09
 Identities = 51/186 (27%), Positives = 89/186 (47%), Gaps = 6/186 (3%)

Query: 7   SPLGASPKKPGCSSPAAAVL----ENQRRELEKLRAELEAERAGWRAERRRFAARERQLR 62
           S  G S +  G  + A A L    E+ R +L  ++ EL+ E++      R      RQ+R
Sbjct: 2   SKRGMSSRAKGDKAEALAALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQVR 61

Query: 63  EEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLH 122
           E  + +   L   L++K   ++ +EL+ ++E + R+ EAE+ ++++ K+ E ++LQ LL 
Sbjct: 62  EHEQHKTAVLLTELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQALLS 121

Query: 123 RERDGVVRQARELQRQLAEELVNRGHCSR--PGASEVSAAQCRCRLQEVLAQLRWQTDGE 180
             RDG   + + +    A+E   +G          E+S  +   R  E    L  Q D  
Sbjct: 122 ALRDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQADKI 181

Query: 181 QAARIR 186
           +AA IR
Sbjct: 182 KAAEIR 187



 Score = 31.2 bits (69), Expect = 8.6
 Identities = 27/90 (30%), Positives = 45/90 (50%), Gaps = 7/90 (7%)

Query: 32  ELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRE-LRQ 90
           ELE +  +   + AG +           +L+   E+ +RQ+   LR + +AQ  RE +  
Sbjct: 742 ELEAMLYDALQQEAGAKVAELLSEEEREKLKVAVEQWKRQVMSELRER-DAQILRERMEL 800

Query: 91  LQEEMQREREAEIRQLLRWKEAEQRQLQQL 120
           LQ   QR +E E R      EA++RQ+++L
Sbjct: 801 LQLAQQRIKELEER-----IEAQKRQIKEL 825


>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
           sapiens]
          Length = 1293

 Score = 60.8 bits (146), Expect = 1e-08
 Identities = 73/263 (27%), Positives = 121/263 (46%), Gaps = 43/263 (16%)

Query: 4   DSPSPLGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLRE 63
           D+ +P  A  +        AA LE +RRE E +RA+ E E    + E RR      + ++
Sbjct: 709 DTTTPGPALEQLQQLEKAKAAKLEQERREAE-MRAKREEEERKRQEELRRQQEEILRRQQ 767

Query: 64  EAERERRQLADRLRSKWE----AQRSREL---RQLQEEMQREREAEIRQL--LRWKEAEQ 114
           E ER+RR+  +  R K E     QR +E+   RQ +EE ++++E  +R+L   R +E E+
Sbjct: 768 EEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEER 827

Query: 115 RQLQQLLHRERDGVVRQAR---ELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLA 171
           R+ ++LL ++ +   + AR   E QR+L E                     R R++E  A
Sbjct: 828 RKQEELLRKQEEEAAKWAREEEEAQRRLEEN--------------------RLRMEEEAA 867

Query: 172 QLRWQTDGEQAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPDPQAVHSLEE-PLP 230
           +LR + +  +       +  LEV+RQ  L  +    +   AL      Q    L +  LP
Sbjct: 868 RLRHEEEERK-------RKELEVQRQKEL--MRQRQQQQEALRRLQQQQQQQQLAQMKLP 918

Query: 231 QTSSGSCHAPKPACQLGSLDSLS 253
            +S+    +   ACQ  +  SL+
Sbjct: 919 SSSTWGQQSNTTACQSQATLSLA 941



 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 46/195 (23%), Positives = 91/195 (46%), Gaps = 43/195 (22%)

Query: 27   ENQRRELEKLRAELEAERAGWRAE----RRRFAARERQLREEAERERRQLADRLRSKWEA 82
            E +RR+ E+L  + E E A W  E    +RR      ++ EEA R R +  +R R + E 
Sbjct: 824  EEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEV 883

Query: 83   QRSREL-----------RQLQEEMQREREAEIR-------------------------QL 106
            QR +EL           R+LQ++ Q+++ A+++                         ++
Sbjct: 884  QRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEI 943

Query: 107  LRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRL 166
             + +E  +RQL++   R++  +++  ++ Q+Q  ++L   G+ S+P  +  S  + +   
Sbjct: 944  QKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQ--- 1000

Query: 167  QEVLAQLRWQTDGEQ 181
            QE   Q++ Q   +Q
Sbjct: 1001 QEEARQMQKQQQQQQ 1015



 Score = 40.8 bits (94), Expect = 0.011
 Identities = 41/148 (27%), Positives = 67/148 (45%), Gaps = 18/148 (12%)

Query: 523 RDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRR 582
           R+ + L R  Q E LR QR+            E   +    EE R+Q     R L++RRR
Sbjct: 774 REEEELARRKQEEALRRQRE-----------QEIALRRQREEEERQQQEEALRRLEERRR 822

Query: 583 ECQELGTQAAPARRRGEEA------ETQLQAALLKNAW-LAEENGRLQAKTDWVRKVEAE 635
           E +E   Q    R++ EEA      E + Q  L +N   + EE  RL+ + +  ++ E E
Sbjct: 823 EEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELE 882

Query: 636 NSEVRGHLGRACQERDASGLIAEQLLQQ 663
               +  + +  Q+++A   + +Q  QQ
Sbjct: 883 VQRQKELMRQRQQQQEALRRLQQQQQQQ 910



 Score = 33.9 bits (76), Expect = 1.3
 Identities = 48/212 (22%), Positives = 92/212 (43%), Gaps = 32/212 (15%)

Query: 564 EEVRRQ---MLALERELDQRRRECQELGT-------------QAAPARRRGEEAETQLQA 607
           EE+RRQ   +L  ++E +++RRE +EL               + A  R+R EE   Q + 
Sbjct: 753 EELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEE 812

Query: 608 ALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQLL---QQA 664
           AL +      E    + + + +RK E E ++       A +E +A   + E  L   ++A
Sbjct: 813 ALRRLEERRREEEERRKQEELLRKQEEEAAK------WAREEEEAQRRLEENRLRMEEEA 866

Query: 665 AR-----GQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKG 719
           AR      + ++++L+   QK L  +    ++ +AL+       +Q     ++P S   G
Sbjct: 867 ARLRHEEEERKRKELEVQRQKEL--MRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWG 924

Query: 720 SRRPKFHARPEDYAVSQPNRDIQEKREASLEE 751
            +      + +        + ++E+RE  L E
Sbjct: 925 QQSNTTACQSQATLSLAEIQKLEEERERQLRE 956



 Score = 33.5 bits (75), Expect = 1.7
 Identities = 45/237 (18%), Positives = 94/237 (39%), Gaps = 21/237 (8%)

Query: 395  QEENKQLRRAGCPYQADEKVKR----LKVKRAELTGLARRLADRARELQETNLRAVSAPI 450
            Q++ + LRR     + +E+ ++    L+ +  E    AR   +  R L+E  LR      
Sbjct: 808  QQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAA 867

Query: 451  PGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPCSDLHT 510
                       +    QR ++L  Q        +++++ +Q+  L Q ++ S       +
Sbjct: 868  RLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQS 927

Query: 511  GRGGPCTQ-WLNVRDLDRL-----------QRESQREVLR-LQRQLMLQQGNGGAWPEAG 557
                  +Q  L++ ++ +L           QR  QRE+++ LQ+Q   QQ     W    
Sbjct: 928  NTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVS 987

Query: 558  GQSATCEEVRRQMLALERELDQRRRECQELGTQAAPARRRGEEAETQLQAALLKNAW 614
              S T     + +L +++E  ++ ++ Q+   Q     R      + L  ++  + W
Sbjct: 988  KPSGT----TKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLHTSIGNSVW 1040



 Score = 33.5 bits (75), Expect = 1.7
 Identities = 35/141 (24%), Positives = 56/141 (39%), Gaps = 45/141 (31%)

Query: 1    MAKDSPSPLGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQ 60
            M   S S  G       C S A   L     E++KL  E                 RERQ
Sbjct: 915  MKLPSSSTWGQQSNTTACQSQATLSLA----EIQKLEEE-----------------RERQ 953

Query: 61   LREEAERERRQLADRLRSKWEAQR---------------SRELRQLQEEMQREREAEIRQ 105
            LREE  R++R+L   L+ + + Q+               ++ L ++Q+E  R+ +     
Sbjct: 954  LREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQ----- 1008

Query: 106  LLRWKEAEQRQLQQLLHRERD 126
                K+ +Q+Q  Q  +R R+
Sbjct: 1009 ----KQQQQQQQHQQPNRARN 1025



 Score = 32.7 bits (73), Expect = 3.0
 Identities = 52/245 (21%), Positives = 95/245 (38%), Gaps = 48/245 (19%)

Query: 481  AKDKQIEELRQECHLLQARVASGPCSDLHTGRG---------GPCTQWLNVRDLDRLQRE 531
            A+  Q ++ +Q+ H    R  +   S+LHT  G         GP  QW +  DL      
Sbjct: 1004 ARQMQKQQQQQQQHQQPNRARNNTHSNLHTSIGNSVWGSINTGPPNQWAS--DL------ 1055

Query: 532  SQREVLRLQRQLMLQQGNGGAWPEA----GGQSATCEEVRRQMLALERELDQRRR---EC 584
                V  +      +  N G W +A    G +++T +      L+    +  R+    E 
Sbjct: 1056 ----VSSIWSNADTKNSNMGFWDDAVKEVGPRNSTNKNKNNASLSKSVGVSNRQNKKVEE 1111

Query: 585  QELGTQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAE---NSEVRG 641
            +E   +      + ++  TQ    +L +A     N  +     ++++VE+    +  +R 
Sbjct: 1112 EEKLLKLFQGVNKAQDGFTQWCEQML-HALNTANNLDVPTFVSFLKEVESPYEVHDYIRA 1170

Query: 642  HLGRACQERDASGLIAEQLLQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGH 701
            +LG   + ++ +    E+  +Q A  Q +QQQL +  Q                Q  P  
Sbjct: 1171 YLGDTSEAKEFAKQFLERRAKQKANQQRQQQQLPQQQQ----------------QQPPQQ 1214

Query: 702  PPEQP 706
            PP+QP
Sbjct: 1215 PPQQP 1219


>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
           sapiens]
          Length = 1320

 Score = 60.8 bits (146), Expect = 1e-08
 Identities = 73/263 (27%), Positives = 121/263 (46%), Gaps = 43/263 (16%)

Query: 4   DSPSPLGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLRE 63
           D+ +P  A  +        AA LE +RRE E +RA+ E E    + E RR      + ++
Sbjct: 736 DTTTPGPALEQLQQLEKAKAAKLEQERREAE-MRAKREEEERKRQEELRRQQEEILRRQQ 794

Query: 64  EAERERRQLADRLRSKWE----AQRSREL---RQLQEEMQREREAEIRQL--LRWKEAEQ 114
           E ER+RR+  +  R K E     QR +E+   RQ +EE ++++E  +R+L   R +E E+
Sbjct: 795 EEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEER 854

Query: 115 RQLQQLLHRERDGVVRQAR---ELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLA 171
           R+ ++LL ++ +   + AR   E QR+L E                     R R++E  A
Sbjct: 855 RKQEELLRKQEEEAAKWAREEEEAQRRLEEN--------------------RLRMEEEAA 894

Query: 172 QLRWQTDGEQAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPDPQAVHSLEE-PLP 230
           +LR + +  +       +  LEV+RQ  L  +    +   AL      Q    L +  LP
Sbjct: 895 RLRHEEEERK-------RKELEVQRQKEL--MRQRQQQQEALRRLQQQQQQQQLAQMKLP 945

Query: 231 QTSSGSCHAPKPACQLGSLDSLS 253
            +S+    +   ACQ  +  SL+
Sbjct: 946 SSSTWGQQSNTTACQSQATLSLA 968



 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 46/195 (23%), Positives = 91/195 (46%), Gaps = 43/195 (22%)

Query: 27   ENQRRELEKLRAELEAERAGWRAE----RRRFAARERQLREEAERERRQLADRLRSKWEA 82
            E +RR+ E+L  + E E A W  E    +RR      ++ EEA R R +  +R R + E 
Sbjct: 851  EEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEV 910

Query: 83   QRSREL-----------RQLQEEMQREREAEIR-------------------------QL 106
            QR +EL           R+LQ++ Q+++ A+++                         ++
Sbjct: 911  QRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEI 970

Query: 107  LRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRL 166
             + +E  +RQL++   R++  +++  ++ Q+Q  ++L   G+ S+P  +  S  + +   
Sbjct: 971  QKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQ--- 1027

Query: 167  QEVLAQLRWQTDGEQ 181
            QE   Q++ Q   +Q
Sbjct: 1028 QEEARQMQKQQQQQQ 1042



 Score = 40.8 bits (94), Expect = 0.011
 Identities = 41/148 (27%), Positives = 67/148 (45%), Gaps = 18/148 (12%)

Query: 523 RDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRR 582
           R+ + L R  Q E LR QR+            E   +    EE R+Q     R L++RRR
Sbjct: 801 REEEELARRKQEEALRRQRE-----------QEIALRRQREEEERQQQEEALRRLEERRR 849

Query: 583 ECQELGTQAAPARRRGEEA------ETQLQAALLKNAW-LAEENGRLQAKTDWVRKVEAE 635
           E +E   Q    R++ EEA      E + Q  L +N   + EE  RL+ + +  ++ E E
Sbjct: 850 EEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELE 909

Query: 636 NSEVRGHLGRACQERDASGLIAEQLLQQ 663
               +  + +  Q+++A   + +Q  QQ
Sbjct: 910 VQRQKELMRQRQQQQEALRRLQQQQQQQ 937



 Score = 33.9 bits (76), Expect = 1.3
 Identities = 48/212 (22%), Positives = 92/212 (43%), Gaps = 32/212 (15%)

Query: 564 EEVRRQ---MLALERELDQRRRECQELGT-------------QAAPARRRGEEAETQLQA 607
           EE+RRQ   +L  ++E +++RRE +EL               + A  R+R EE   Q + 
Sbjct: 780 EELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEE 839

Query: 608 ALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQLL---QQA 664
           AL +      E    + + + +RK E E ++       A +E +A   + E  L   ++A
Sbjct: 840 ALRRLEERRREEEERRKQEELLRKQEEEAAK------WAREEEEAQRRLEENRLRMEEEA 893

Query: 665 AR-----GQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKG 719
           AR      + ++++L+   QK L  +    ++ +AL+       +Q     ++P S   G
Sbjct: 894 ARLRHEEEERKRKELEVQRQKEL--MRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWG 951

Query: 720 SRRPKFHARPEDYAVSQPNRDIQEKREASLEE 751
            +      + +        + ++E+RE  L E
Sbjct: 952 QQSNTTACQSQATLSLAEIQKLEEERERQLRE 983



 Score = 33.5 bits (75), Expect = 1.7
 Identities = 45/237 (18%), Positives = 94/237 (39%), Gaps = 21/237 (8%)

Query: 395  QEENKQLRRAGCPYQADEKVKR----LKVKRAELTGLARRLADRARELQETNLRAVSAPI 450
            Q++ + LRR     + +E+ ++    L+ +  E    AR   +  R L+E  LR      
Sbjct: 835  QQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAA 894

Query: 451  PGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPCSDLHT 510
                       +    QR ++L  Q        +++++ +Q+  L Q ++ S       +
Sbjct: 895  RLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQS 954

Query: 511  GRGGPCTQ-WLNVRDLDRL-----------QRESQREVLR-LQRQLMLQQGNGGAWPEAG 557
                  +Q  L++ ++ +L           QR  QRE+++ LQ+Q   QQ     W    
Sbjct: 955  NTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVS 1014

Query: 558  GQSATCEEVRRQMLALERELDQRRRECQELGTQAAPARRRGEEAETQLQAALLKNAW 614
              S T     + +L +++E  ++ ++ Q+   Q     R      + L  ++  + W
Sbjct: 1015 KPSGT----TKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLHTSIGNSVW 1067



 Score = 33.5 bits (75), Expect = 1.7
 Identities = 35/141 (24%), Positives = 56/141 (39%), Gaps = 45/141 (31%)

Query: 1    MAKDSPSPLGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQ 60
            M   S S  G       C S A   L     E++KL  E                 RERQ
Sbjct: 942  MKLPSSSTWGQQSNTTACQSQATLSLA----EIQKLEEE-----------------RERQ 980

Query: 61   LREEAERERRQLADRLRSKWEAQR---------------SRELRQLQEEMQREREAEIRQ 105
            LREE  R++R+L   L+ + + Q+               ++ L ++Q+E  R+ +     
Sbjct: 981  LREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQ----- 1035

Query: 106  LLRWKEAEQRQLQQLLHRERD 126
                K+ +Q+Q  Q  +R R+
Sbjct: 1036 ----KQQQQQQQHQQPNRARN 1052



 Score = 32.7 bits (73), Expect = 3.0
 Identities = 52/245 (21%), Positives = 95/245 (38%), Gaps = 48/245 (19%)

Query: 481  AKDKQIEELRQECHLLQARVASGPCSDLHTGRG---------GPCTQWLNVRDLDRLQRE 531
            A+  Q ++ +Q+ H    R  +   S+LHT  G         GP  QW +  DL      
Sbjct: 1031 ARQMQKQQQQQQQHQQPNRARNNTHSNLHTSIGNSVWGSINTGPPNQWAS--DL------ 1082

Query: 532  SQREVLRLQRQLMLQQGNGGAWPEA----GGQSATCEEVRRQMLALERELDQRRR---EC 584
                V  +      +  N G W +A    G +++T +      L+    +  R+    E 
Sbjct: 1083 ----VSSIWSNADTKNSNMGFWDDAVKEVGPRNSTNKNKNNASLSKSVGVSNRQNKKVEE 1138

Query: 585  QELGTQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAE---NSEVRG 641
            +E   +      + ++  TQ    +L +A     N  +     ++++VE+    +  +R 
Sbjct: 1139 EEKLLKLFQGVNKAQDGFTQWCEQML-HALNTANNLDVPTFVSFLKEVESPYEVHDYIRA 1197

Query: 642  HLGRACQERDASGLIAEQLLQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGH 701
            +LG   + ++ +    E+  +Q A  Q +QQQL +  Q                Q  P  
Sbjct: 1198 YLGDTSEAKEFAKQFLERRAKQKANQQRQQQQLPQQQQ----------------QQPPQQ 1241

Query: 702  PPEQP 706
            PP+QP
Sbjct: 1242 PPQQP 1246


>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
           sapiens]
          Length = 1299

 Score = 60.8 bits (146), Expect = 1e-08
 Identities = 73/263 (27%), Positives = 121/263 (46%), Gaps = 43/263 (16%)

Query: 4   DSPSPLGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLRE 63
           D+ +P  A  +        AA LE +RRE E +RA+ E E    + E RR      + ++
Sbjct: 715 DTTTPGPALEQLQQLEKAKAAKLEQERREAE-MRAKREEEERKRQEELRRQQEEILRRQQ 773

Query: 64  EAERERRQLADRLRSKWE----AQRSREL---RQLQEEMQREREAEIRQL--LRWKEAEQ 114
           E ER+RR+  +  R K E     QR +E+   RQ +EE ++++E  +R+L   R +E E+
Sbjct: 774 EEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEER 833

Query: 115 RQLQQLLHRERDGVVRQAR---ELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLA 171
           R+ ++LL ++ +   + AR   E QR+L E                     R R++E  A
Sbjct: 834 RKQEELLRKQEEEAAKWAREEEEAQRRLEEN--------------------RLRMEEEAA 873

Query: 172 QLRWQTDGEQAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPDPQAVHSLEE-PLP 230
           +LR + +  +       +  LEV+RQ  L  +    +   AL      Q    L +  LP
Sbjct: 874 RLRHEEEERK-------RKELEVQRQKEL--MRQRQQQQEALRRLQQQQQQQQLAQMKLP 924

Query: 231 QTSSGSCHAPKPACQLGSLDSLS 253
            +S+    +   ACQ  +  SL+
Sbjct: 925 SSSTWGQQSNTTACQSQATLSLA 947



 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 46/195 (23%), Positives = 91/195 (46%), Gaps = 43/195 (22%)

Query: 27   ENQRRELEKLRAELEAERAGWRAE----RRRFAARERQLREEAERERRQLADRLRSKWEA 82
            E +RR+ E+L  + E E A W  E    +RR      ++ EEA R R +  +R R + E 
Sbjct: 830  EEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEV 889

Query: 83   QRSREL-----------RQLQEEMQREREAEIR-------------------------QL 106
            QR +EL           R+LQ++ Q+++ A+++                         ++
Sbjct: 890  QRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEI 949

Query: 107  LRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRL 166
             + +E  +RQL++   R++  +++  ++ Q+Q  ++L   G+ S+P  +  S  + +   
Sbjct: 950  QKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQ--- 1006

Query: 167  QEVLAQLRWQTDGEQ 181
            QE   Q++ Q   +Q
Sbjct: 1007 QEEARQMQKQQQQQQ 1021



 Score = 40.8 bits (94), Expect = 0.011
 Identities = 41/148 (27%), Positives = 67/148 (45%), Gaps = 18/148 (12%)

Query: 523 RDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRR 582
           R+ + L R  Q E LR QR+            E   +    EE R+Q     R L++RRR
Sbjct: 780 REEEELARRKQEEALRRQRE-----------QEIALRRQREEEERQQQEEALRRLEERRR 828

Query: 583 ECQELGTQAAPARRRGEEA------ETQLQAALLKNAW-LAEENGRLQAKTDWVRKVEAE 635
           E +E   Q    R++ EEA      E + Q  L +N   + EE  RL+ + +  ++ E E
Sbjct: 829 EEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELE 888

Query: 636 NSEVRGHLGRACQERDASGLIAEQLLQQ 663
               +  + +  Q+++A   + +Q  QQ
Sbjct: 889 VQRQKELMRQRQQQQEALRRLQQQQQQQ 916



 Score = 33.9 bits (76), Expect = 1.3
 Identities = 48/212 (22%), Positives = 92/212 (43%), Gaps = 32/212 (15%)

Query: 564 EEVRRQ---MLALERELDQRRRECQELGT-------------QAAPARRRGEEAETQLQA 607
           EE+RRQ   +L  ++E +++RRE +EL               + A  R+R EE   Q + 
Sbjct: 759 EELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEE 818

Query: 608 ALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQLL---QQA 664
           AL +      E    + + + +RK E E ++       A +E +A   + E  L   ++A
Sbjct: 819 ALRRLEERRREEEERRKQEELLRKQEEEAAK------WAREEEEAQRRLEENRLRMEEEA 872

Query: 665 AR-----GQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKG 719
           AR      + ++++L+   QK L  +    ++ +AL+       +Q     ++P S   G
Sbjct: 873 ARLRHEEEERKRKELEVQRQKEL--MRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWG 930

Query: 720 SRRPKFHARPEDYAVSQPNRDIQEKREASLEE 751
            +      + +        + ++E+RE  L E
Sbjct: 931 QQSNTTACQSQATLSLAEIQKLEEERERQLRE 962



 Score = 33.5 bits (75), Expect = 1.7
 Identities = 45/237 (18%), Positives = 94/237 (39%), Gaps = 21/237 (8%)

Query: 395  QEENKQLRRAGCPYQADEKVKR----LKVKRAELTGLARRLADRARELQETNLRAVSAPI 450
            Q++ + LRR     + +E+ ++    L+ +  E    AR   +  R L+E  LR      
Sbjct: 814  QQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAA 873

Query: 451  PGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPCSDLHT 510
                       +    QR ++L  Q        +++++ +Q+  L Q ++ S       +
Sbjct: 874  RLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQS 933

Query: 511  GRGGPCTQ-WLNVRDLDRL-----------QRESQREVLR-LQRQLMLQQGNGGAWPEAG 557
                  +Q  L++ ++ +L           QR  QRE+++ LQ+Q   QQ     W    
Sbjct: 934  NTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVS 993

Query: 558  GQSATCEEVRRQMLALERELDQRRRECQELGTQAAPARRRGEEAETQLQAALLKNAW 614
              S T     + +L +++E  ++ ++ Q+   Q     R      + L  ++  + W
Sbjct: 994  KPSGT----TKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLHTSIGNSVW 1046



 Score = 33.5 bits (75), Expect = 1.7
 Identities = 35/141 (24%), Positives = 56/141 (39%), Gaps = 45/141 (31%)

Query: 1    MAKDSPSPLGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQ 60
            M   S S  G       C S A   L     E++KL  E                 RERQ
Sbjct: 921  MKLPSSSTWGQQSNTTACQSQATLSLA----EIQKLEEE-----------------RERQ 959

Query: 61   LREEAERERRQLADRLRSKWEAQR---------------SRELRQLQEEMQREREAEIRQ 105
            LREE  R++R+L   L+ + + Q+               ++ L ++Q+E  R+ +     
Sbjct: 960  LREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQ----- 1014

Query: 106  LLRWKEAEQRQLQQLLHRERD 126
                K+ +Q+Q  Q  +R R+
Sbjct: 1015 ----KQQQQQQQHQQPNRARN 1031



 Score = 32.7 bits (73), Expect = 3.0
 Identities = 52/245 (21%), Positives = 95/245 (38%), Gaps = 48/245 (19%)

Query: 481  AKDKQIEELRQECHLLQARVASGPCSDLHTGRG---------GPCTQWLNVRDLDRLQRE 531
            A+  Q ++ +Q+ H    R  +   S+LHT  G         GP  QW +  DL      
Sbjct: 1010 ARQMQKQQQQQQQHQQPNRARNNTHSNLHTSIGNSVWGSINTGPPNQWAS--DL------ 1061

Query: 532  SQREVLRLQRQLMLQQGNGGAWPEA----GGQSATCEEVRRQMLALERELDQRRR---EC 584
                V  +      +  N G W +A    G +++T +      L+    +  R+    E 
Sbjct: 1062 ----VSSIWSNADTKNSNMGFWDDAVKEVGPRNSTNKNKNNASLSKSVGVSNRQNKKVEE 1117

Query: 585  QELGTQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAE---NSEVRG 641
            +E   +      + ++  TQ    +L +A     N  +     ++++VE+    +  +R 
Sbjct: 1118 EEKLLKLFQGVNKAQDGFTQWCEQML-HALNTANNLDVPTFVSFLKEVESPYEVHDYIRA 1176

Query: 642  HLGRACQERDASGLIAEQLLQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGH 701
            +LG   + ++ +    E+  +Q A  Q +QQQL +  Q                Q  P  
Sbjct: 1177 YLGDTSEAKEFAKQFLERRAKQKANQQRQQQQLPQQQQ----------------QQPPQQ 1220

Query: 702  PPEQP 706
            PP+QP
Sbjct: 1221 PPQQP 1225


>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
           sapiens]
          Length = 1299

 Score = 60.8 bits (146), Expect = 1e-08
 Identities = 73/263 (27%), Positives = 121/263 (46%), Gaps = 43/263 (16%)

Query: 4   DSPSPLGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLRE 63
           D+ +P  A  +        AA LE +RRE E +RA+ E E    + E RR      + ++
Sbjct: 715 DTTTPGPALEQLQQLEKAKAAKLEQERREAE-MRAKREEEERKRQEELRRQQEEILRRQQ 773

Query: 64  EAERERRQLADRLRSKWE----AQRSREL---RQLQEEMQREREAEIRQL--LRWKEAEQ 114
           E ER+RR+  +  R K E     QR +E+   RQ +EE ++++E  +R+L   R +E E+
Sbjct: 774 EEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEER 833

Query: 115 RQLQQLLHRERDGVVRQAR---ELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLA 171
           R+ ++LL ++ +   + AR   E QR+L E                     R R++E  A
Sbjct: 834 RKQEELLRKQEEEAAKWAREEEEAQRRLEEN--------------------RLRMEEEAA 873

Query: 172 QLRWQTDGEQAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPDPQAVHSLEE-PLP 230
           +LR + +  +       +  LEV+RQ  L  +    +   AL      Q    L +  LP
Sbjct: 874 RLRHEEEERK-------RKELEVQRQKEL--MRQRQQQQEALRRLQQQQQQQQLAQMKLP 924

Query: 231 QTSSGSCHAPKPACQLGSLDSLS 253
            +S+    +   ACQ  +  SL+
Sbjct: 925 SSSTWGQQSNTTACQSQATLSLA 947



 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 46/195 (23%), Positives = 91/195 (46%), Gaps = 43/195 (22%)

Query: 27   ENQRRELEKLRAELEAERAGWRAE----RRRFAARERQLREEAERERRQLADRLRSKWEA 82
            E +RR+ E+L  + E E A W  E    +RR      ++ EEA R R +  +R R + E 
Sbjct: 830  EEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEV 889

Query: 83   QRSREL-----------RQLQEEMQREREAEIR-------------------------QL 106
            QR +EL           R+LQ++ Q+++ A+++                         ++
Sbjct: 890  QRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEI 949

Query: 107  LRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRL 166
             + +E  +RQL++   R++  +++  ++ Q+Q  ++L   G+ S+P  +  S  + +   
Sbjct: 950  QKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQ--- 1006

Query: 167  QEVLAQLRWQTDGEQ 181
            QE   Q++ Q   +Q
Sbjct: 1007 QEEARQMQKQQQQQQ 1021



 Score = 40.8 bits (94), Expect = 0.011
 Identities = 41/148 (27%), Positives = 67/148 (45%), Gaps = 18/148 (12%)

Query: 523 RDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRR 582
           R+ + L R  Q E LR QR+            E   +    EE R+Q     R L++RRR
Sbjct: 780 REEEELARRKQEEALRRQRE-----------QEIALRRQREEEERQQQEEALRRLEERRR 828

Query: 583 ECQELGTQAAPARRRGEEA------ETQLQAALLKNAW-LAEENGRLQAKTDWVRKVEAE 635
           E +E   Q    R++ EEA      E + Q  L +N   + EE  RL+ + +  ++ E E
Sbjct: 829 EEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELE 888

Query: 636 NSEVRGHLGRACQERDASGLIAEQLLQQ 663
               +  + +  Q+++A   + +Q  QQ
Sbjct: 889 VQRQKELMRQRQQQQEALRRLQQQQQQQ 916



 Score = 33.9 bits (76), Expect = 1.3
 Identities = 48/212 (22%), Positives = 92/212 (43%), Gaps = 32/212 (15%)

Query: 564 EEVRRQ---MLALERELDQRRRECQELGT-------------QAAPARRRGEEAETQLQA 607
           EE+RRQ   +L  ++E +++RRE +EL               + A  R+R EE   Q + 
Sbjct: 759 EELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEE 818

Query: 608 ALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQLL---QQA 664
           AL +      E    + + + +RK E E ++       A +E +A   + E  L   ++A
Sbjct: 819 ALRRLEERRREEEERRKQEELLRKQEEEAAK------WAREEEEAQRRLEENRLRMEEEA 872

Query: 665 AR-----GQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKG 719
           AR      + ++++L+   QK L  +    ++ +AL+       +Q     ++P S   G
Sbjct: 873 ARLRHEEEERKRKELEVQRQKEL--MRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWG 930

Query: 720 SRRPKFHARPEDYAVSQPNRDIQEKREASLEE 751
            +      + +        + ++E+RE  L E
Sbjct: 931 QQSNTTACQSQATLSLAEIQKLEEERERQLRE 962



 Score = 33.5 bits (75), Expect = 1.7
 Identities = 45/237 (18%), Positives = 94/237 (39%), Gaps = 21/237 (8%)

Query: 395  QEENKQLRRAGCPYQADEKVKR----LKVKRAELTGLARRLADRARELQETNLRAVSAPI 450
            Q++ + LRR     + +E+ ++    L+ +  E    AR   +  R L+E  LR      
Sbjct: 814  QQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAA 873

Query: 451  PGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPCSDLHT 510
                       +    QR ++L  Q        +++++ +Q+  L Q ++ S       +
Sbjct: 874  RLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQS 933

Query: 511  GRGGPCTQ-WLNVRDLDRL-----------QRESQREVLR-LQRQLMLQQGNGGAWPEAG 557
                  +Q  L++ ++ +L           QR  QRE+++ LQ+Q   QQ     W    
Sbjct: 934  NTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVS 993

Query: 558  GQSATCEEVRRQMLALERELDQRRRECQELGTQAAPARRRGEEAETQLQAALLKNAW 614
              S T     + +L +++E  ++ ++ Q+   Q     R      + L  ++  + W
Sbjct: 994  KPSGT----TKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLHTSIGNSVW 1046



 Score = 33.5 bits (75), Expect = 1.7
 Identities = 35/141 (24%), Positives = 56/141 (39%), Gaps = 45/141 (31%)

Query: 1    MAKDSPSPLGASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQ 60
            M   S S  G       C S A   L     E++KL  E                 RERQ
Sbjct: 921  MKLPSSSTWGQQSNTTACQSQATLSLA----EIQKLEEE-----------------RERQ 959

Query: 61   LREEAERERRQLADRLRSKWEAQR---------------SRELRQLQEEMQREREAEIRQ 105
            LREE  R++R+L   L+ + + Q+               ++ L ++Q+E  R+ +     
Sbjct: 960  LREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQ----- 1014

Query: 106  LLRWKEAEQRQLQQLLHRERD 126
                K+ +Q+Q  Q  +R R+
Sbjct: 1015 ----KQQQQQQQHQQPNRARN 1031



 Score = 32.7 bits (73), Expect = 3.0
 Identities = 52/245 (21%), Positives = 95/245 (38%), Gaps = 48/245 (19%)

Query: 481  AKDKQIEELRQECHLLQARVASGPCSDLHTGRG---------GPCTQWLNVRDLDRLQRE 531
            A+  Q ++ +Q+ H    R  +   S+LHT  G         GP  QW +  DL      
Sbjct: 1010 ARQMQKQQQQQQQHQQPNRARNNTHSNLHTSIGNSVWGSINTGPPNQWAS--DL------ 1061

Query: 532  SQREVLRLQRQLMLQQGNGGAWPEA----GGQSATCEEVRRQMLALERELDQRRR---EC 584
                V  +      +  N G W +A    G +++T +      L+    +  R+    E 
Sbjct: 1062 ----VSSIWSNADTKNSNMGFWDDAVKEVGPRNSTNKNKNNASLSKSVGVSNRQNKKVEE 1117

Query: 585  QELGTQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAE---NSEVRG 641
            +E   +      + ++  TQ    +L +A     N  +     ++++VE+    +  +R 
Sbjct: 1118 EEKLLKLFQGVNKAQDGFTQWCEQML-HALNTANNLDVPTFVSFLKEVESPYEVHDYIRA 1176

Query: 642  HLGRACQERDASGLIAEQLLQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGH 701
            +LG   + ++ +    E+  +Q A  Q +QQQL +  Q                Q  P  
Sbjct: 1177 YLGDTSEAKEFAKQFLERRAKQKANQQRQQQQLPQQQQ----------------QQPPQQ 1220

Query: 702  PPEQP 706
            PP+QP
Sbjct: 1221 PPQQP 1225


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 42/125 (33%), Positives = 72/125 (57%), Gaps = 7/125 (5%)

Query: 27  ENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSR 86
           + +RRE ++ R E + ER   +  R +   RE+QLR E E ERR+   R R + E +R +
Sbjct: 318 QEERREQQE-RREQQEERREQQLRREQEERREQQLRREQEEERREQQLR-REQEEERREQ 375

Query: 87  ELR---QLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEEL 143
           +LR   QL+ E Q  RE ++R+  + +  +Q + +Q L RE+   +R+ ++L+R+  EE 
Sbjct: 376 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ--LRREQQLRREQEEER 433

Query: 144 VNRGH 148
             + H
Sbjct: 434 HEQKH 438



 Score = 58.9 bits (141), Expect = 4e-08
 Identities = 54/175 (30%), Positives = 83/175 (47%), Gaps = 28/175 (16%)

Query: 26   LENQRRELEKLRAELEAERAGWRAERRRFAARERQ--------------LREEAERERRQ 71
            LE Q R+ E+L+ E E +      E+RR   RERQ              LREE E+ RRQ
Sbjct: 1076 LERQYRKEEELQQE-EEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQ 1134

Query: 72   LADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQ 131
              +R   + E  +  E + L+EE ++ R  E+ +  R +E  Q++ +QLL RE     RQ
Sbjct: 1135 ELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLL-REEQEKRRQ 1193

Query: 132  ARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIR 186
             RE Q +  EEL            +    + R R ++  + L+WQ + E+   +R
Sbjct: 1194 ERERQYREEEEL------------QRQKRKQRYRDEDQRSDLKWQWEPEKENAVR 1236



 Score = 58.5 bits (140), Expect = 5e-08
 Identities = 49/173 (28%), Positives = 87/173 (50%), Gaps = 15/173 (8%)

Query: 27  ENQRRELEKLRAE--LEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQR 84
           E +R +L K   E  LE ER   R +R +   R++ L+ E ER +++L      + E + 
Sbjct: 543 EERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRL 602

Query: 85  SRE-LRQLQEEMQRER--------EAEIRQLLRWKEAEQRQLQQLLHRERD-GVVRQARE 134
            RE + +L++E +RE+        E   +QLL+ +E E+R+ QQL   +++    R  RE
Sbjct: 603 KREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKRE 662

Query: 135 LQRQLAEELVNRGHCSRPGASEVS---AAQCRCRLQEVLAQLRWQTDGEQAAR 184
            + +  E+ + R H       E++     Q R R++  + + +WQ + E  AR
Sbjct: 663 EEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADAR 715



 Score = 57.8 bits (138), Expect = 9e-08
 Identities = 38/118 (32%), Positives = 66/118 (55%), Gaps = 3/118 (2%)

Query: 26  LENQRRELEKL-RAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQR 84
           L+ +  +L KL R EL  ER     +++R   RE+QLR + E ERR+  +  R + E + 
Sbjct: 271 LQEEEEQLRKLERQELRRERQEEEQQQQRLR-REQQLRRKQEEERREQQEERREQQERRE 329

Query: 85  SRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEE 142
            +E R+ +++++RE+E    Q LR ++ E+R+ QQL   + +    Q    ++QL  E
Sbjct: 330 QQEERR-EQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRRE 386



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 45/130 (34%), Positives = 66/130 (50%), Gaps = 17/130 (13%)

Query: 27   ENQRRELEKLRAELEAERAGWRAERRRFAARERQ--------------LREEAERERRQL 72
            E Q RE E+L+ E E +  G   E RR    ERQ              LREE E+ RRQ 
Sbjct: 1047 ERQYREEEELQQE-EEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQE 1105

Query: 73   ADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQA 132
             +R   + E  +  E + L+EE ++ R  E+ +  R +E  Q++ +QLL  E +   R+ 
Sbjct: 1106 RERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPE--KRRR 1163

Query: 133  RELQRQLAEE 142
            +EL+RQ  EE
Sbjct: 1164 QELERQYREE 1173



 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 43/117 (36%), Positives = 63/117 (53%), Gaps = 2/117 (1%)

Query: 27   ENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSR 86
            E QR E EK R + E ER  +R E +     E+ LREE E+ RRQ  +R   K +  + +
Sbjct: 912  ELQREEREKRRRQ-EQERQ-YREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQK 969

Query: 87   ELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEEL 143
            E + L EE ++ R  E  +  R +E  Q++ +QLL  ER+   RQ  E Q +  +EL
Sbjct: 970  EEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDEL 1026



 Score = 55.8 bits (133), Expect = 3e-07
 Identities = 56/172 (32%), Positives = 86/172 (50%), Gaps = 12/172 (6%)

Query: 29  QRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRE- 87
           +RREL +LR +   E+   R ER+     +R  +EE E+E R+    LR + E  +  E 
Sbjct: 211 RRRELLELRRKGREEKQQQRRERQ-----DRVFQEEEEKEWRKRETVLRKEEEKLQEEEP 265

Query: 88  --LRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVN 145
              R+LQEE ++ R+ E RQ LR +  E+ Q QQ L RE+  + R+  E +R+  EE   
Sbjct: 266 QRQRELQEEEEQLRKLE-RQELRRERQEEEQQQQRLRREQQ-LRRKQEEERREQQEE--R 321

Query: 146 RGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQ 197
           R    R    E    Q   R QE   + + + + E+  R + L+   E ER+
Sbjct: 322 REQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERR 373



 Score = 55.8 bits (133), Expect = 3e-07
 Identities = 51/179 (28%), Positives = 86/179 (48%), Gaps = 19/179 (10%)

Query: 27  ENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSR 86
           + +RRE ++LR E E  R       +    RE+QLR E E ERR+   +LR + + +R +
Sbjct: 331 QEERRE-QQLRREQEERREQQLRREQEEERREQQLRREQEEERRE--QQLRREQQLRREQ 387

Query: 87  ELR---QLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRER-----DGVVRQARELQRQ 138
           +LR   QL+ E Q  RE ++R+  + +  +Q + +Q L RE+     +    Q R  QR 
Sbjct: 388 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRL 447

Query: 139 LAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQ 197
             E+   R    R   +E        R ++   + + + D E+  R R+L+   E  R+
Sbjct: 448 KREQEERRDWLKREEETE--------RHEQERRKQQLKRDQEEERRERWLKLEEEERRE 498



 Score = 55.5 bits (132), Expect = 4e-07
 Identities = 44/130 (33%), Positives = 65/130 (50%), Gaps = 17/130 (13%)

Query: 27   ENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAE--------------RERRQL 72
            E Q R+ ++L+ E E +      E+RR   RERQ REE E                RRQ 
Sbjct: 1017 ERQYRKKDELQQE-EEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQE 1075

Query: 73   ADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQA 132
             +R   K E  +  E + L+EE ++ R  E  +  R +E  Q++ +QLL  ER+   R+ 
Sbjct: 1076 LERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREERE--KRRR 1133

Query: 133  RELQRQLAEE 142
            +EL+RQ  EE
Sbjct: 1134 QELERQYREE 1143



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 44/131 (33%), Positives = 64/131 (48%), Gaps = 15/131 (11%)

Query: 27   ENQRRELEKLRAELEAERAGWRAERRRFAARERQLR--------------EEAERERRQL 72
            E Q RE E+L+ E E +      E+RR   RERQ R              EE E+ RRQ 
Sbjct: 927  ERQYREEEQLQQE-EEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQE 985

Query: 73   ADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQA 132
             ++   + E  +  E + L+EE ++ R  E  +  R K+  Q++ +QLL  ER+    Q 
Sbjct: 986  REKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQE 1045

Query: 133  RELQRQLAEEL 143
            RE Q +  EEL
Sbjct: 1046 RERQYREEEEL 1056



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 45/175 (25%), Positives = 80/175 (45%), Gaps = 11/175 (6%)

Query: 27  ENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSR 86
           + QRRE +  R   E E   WR         E +L+EE  + +R+L +      + +R  
Sbjct: 227 QQQRRERQD-RVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQE 285

Query: 87  ELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVNR 146
             R+ QEE Q+++     Q LR K+ E+R+ QQ   RE+    ++ RE Q +  E+ + R
Sbjct: 286 LRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQ----QERREQQEERREQQLRR 341

Query: 147 GHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQLFLK 201
                    E    Q R   +E   + + + + E+  R + L+   ++ R+  L+
Sbjct: 342 EQ------EERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLR 390



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 56/188 (29%), Positives = 85/188 (45%), Gaps = 22/188 (11%)

Query: 27   ENQRRELEKLRAELEAERAGWRAERRRFAARERQ--------------LREEAERERRQL 72
            E Q R+ +KL+ + E +  G   E+RR   RE++              LREE E+ RRQ 
Sbjct: 957  ERQYRKDKKLQQK-EEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQE 1015

Query: 73   ADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQA 132
             +R   K +  +  E + L+EE ++ R  E  +  R +E  Q++ +QLL  ER+   RQ 
Sbjct: 1016 WERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQE 1075

Query: 133  RELQRQLAEELVNRGH---CSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQ 189
             E Q +  EEL           P        + +CR +E L Q   Q   E+  + R   
Sbjct: 1076 LERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRR--- 1132

Query: 190  AALEVERQ 197
               E+ERQ
Sbjct: 1133 -RQELERQ 1139



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 51/183 (27%), Positives = 87/183 (47%), Gaps = 26/183 (14%)

Query: 27   ENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSR 86
            E Q R  E+ R  L+ E+   R E  R    E QLR+E E+E+ +  +R R   E ++ R
Sbjct: 1697 EQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLR 1756

Query: 87   ELRQLQEEMQREREAEIR-----------QLLRWKEA-----------EQRQLQQLLHRE 124
              R+ Q+  ++ER+ + R           Q LR +E+           ++R+ QQL  ++
Sbjct: 1757 PEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQ 1816

Query: 125  RDGVVR-QARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAA 183
            RDG  R +  +LQ +  E+ + +    +  A E  A Q + R +E   Q  WQ + ++  
Sbjct: 1817 RDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREE---QELWQEEEQKRR 1873

Query: 184  RIR 186
            + R
Sbjct: 1874 QER 1876



 Score = 52.4 bits (124), Expect = 4e-06
 Identities = 41/109 (37%), Positives = 66/109 (60%), Gaps = 17/109 (15%)

Query: 30  RRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELR 89
           RRE ++LR + E ER   + ERR     E+Q R E + ERR+   +LR + E +R ++LR
Sbjct: 301 RRE-QQLRRKQEEERREQQEERR-----EQQERREQQEERRE--QQLRREQEERREQQLR 352

Query: 90  QLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQ 138
           + QEE +RE      Q LR ++ E+R+ QQL    R+  +R+ ++L+R+
Sbjct: 353 REQEEERRE------QQLRREQEEERREQQL---RREQQLRREQQLRRE 392



 Score = 51.6 bits (122), Expect = 6e-06
 Identities = 55/188 (29%), Positives = 86/188 (45%), Gaps = 28/188 (14%)

Query: 26   LENQRRELE-------KLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADR--L 76
            L  Q RE +       K R E +  + G   + RR   R+R+ REE ++ RRQ  +R  L
Sbjct: 1652 LRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRR-QERDRKFREEEQQLRRQERERKFL 1710

Query: 77   RSKWEAQRSRELRQLQEEMQREREAEIRQLLRWK------EAEQ----RQLQQLLHRERD 126
            + + + +R    R+ +EE Q  +E E  QL R +      E EQ    R+ QQL  +ERD
Sbjct: 1711 QEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERD 1770

Query: 127  GVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCR----CRLQEVLAQLRWQTD---- 178
               R+  +L+++  E+ +      R    E    Q R     R Q+   + RW+ +    
Sbjct: 1771 RKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQL 1830

Query: 179  GEQAARIR 186
             EQ  R+R
Sbjct: 1831 EEQEQRLR 1838



 Score = 51.2 bits (121), Expect = 8e-06
 Identities = 53/182 (29%), Positives = 88/182 (48%), Gaps = 20/182 (10%)

Query: 27   ENQRRELEKLRAELEAERAGWRAER-RRFAARERQLREEAERERRQLADRLRSKWEAQRS 85
            E + R  E  R  LE E+   R +R R+F   E+QLR + ER +++  DR R   E ++ 
Sbjct: 1505 EQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQ-ERGQQRRQDRDRKFREEEQL 1563

Query: 86   RELRQLQEEMQREREAEIR---QLLRWKEAEQRQL-----------QQLLHRERDGVVRQ 131
            R+ R+ Q+  ++ER+ + R   Q +R +E E++ +           QQ L +ERD   R+
Sbjct: 1564 RQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFRE 1623

Query: 132  ARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAA 191
              +L ++  E+ ++R    R    E    + + R QE   QLR   D +     + LQ  
Sbjct: 1624 DEQLLQEREEQQLHRQERDRKFLEE----EPQLRRQEREQQLRHDRDRKFREEEQLLQEG 1679

Query: 192  LE 193
             E
Sbjct: 1680 EE 1681



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 41/125 (32%), Positives = 67/125 (53%), Gaps = 16/125 (12%)

Query: 27  ENQRRELEKLRAELEAERAGW-----RAERRRFAARERQLREEAERERRQLADRLRSKWE 81
           E +RRE ++L+ E E ER  W       ER     R++QL+ + E ERR+   +L    E
Sbjct: 439 EQERRE-QRLKREQE-ERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLE---E 493

Query: 82  AQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAE 141
            +R  +  + +++++RE+E    Q L+ +E E+R LQQ L  E     +Q R  Q +  E
Sbjct: 494 EERREQQERREQQLRREQEERREQRLKRQEEEER-LQQRLRSE-----QQLRREQEERRE 547

Query: 142 ELVNR 146
           +L+ R
Sbjct: 548 QLLKR 552



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 57/196 (29%), Positives = 83/196 (42%), Gaps = 38/196 (19%)

Query: 27  ENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRS---KWEAQ 83
           E Q R  ++L+ E E ER   R +R      ER+ +E AE E+ Q  +R++S   KW+ Q
Sbjct: 650 EQQERREQRLKREEEEERLEQRLKREH--EEERREQELAEEEQEQARERIKSRIPKWQWQ 707

Query: 84  RSREL-------------------RQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRE 124
              E                    RQ QEE +R RE+E    L+W+E E+   QQ    +
Sbjct: 708 LESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESE----LQWQEEERAHRQQQEEEQ 763

Query: 125 RDGVVRQARELQRQLAEELVNRGH---CSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQ 181
           R     Q +      AEE   RG     +RP   E    Q R   ++   Q R+  + E+
Sbjct: 764 RRDFTWQWQ------AEEKSERGRQRLSARPPLREQRERQLRAEERQQREQ-RFLPEEEE 816

Query: 182 AARIRYLQAALEVERQ 197
             + R  +   E E Q
Sbjct: 817 KEQRRRQRREREKELQ 832



 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 57/187 (30%), Positives = 84/187 (44%), Gaps = 19/187 (10%)

Query: 27  ENQRRELEKLRAELEAERAGWRAERRRFAAR-------ERQLREEAERERRQLADRLRSK 79
           E Q R  ++LR E E ER   R +R+    R       E+QLR E E  R QL  R   K
Sbjct: 498 EQQERREQQLRREQE-ERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEK 556

Query: 80  WEAQRSRELRQLQEEMQR-----EREAEIRQLLRWKEAEQRQLQQLLHRER----DGVVR 130
              Q  RE R  +E+ +R     +RE E RQ  R K  ++ +L+Q L RE     +   R
Sbjct: 557 RLEQERREQRLKREQEERRDQLLKREEERRQQ-RLKREQEERLEQRLKREEVERLEQEER 615

Query: 131 QARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQA 190
           + + L+R+  EE   R    +    E    Q   R Q+   + R + + E+    + L+ 
Sbjct: 616 REQRLKREEPEE-ERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKR 674

Query: 191 ALEVERQ 197
             E ER+
Sbjct: 675 EHEEERR 681



 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 53/175 (30%), Positives = 80/175 (45%), Gaps = 16/175 (9%)

Query: 27  ENQRRELE-KLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADR--LRSKWEAQ 83
           + +RRE E + + E  A R     E+RR    + Q  E++ER R++L+ R  LR + E Q
Sbjct: 738 KRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQ 797

Query: 84  RSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEEL 143
              E RQ +E+     E E  Q  R +   +++LQ L   E+     Q RE  +QL EE 
Sbjct: 798 LRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQ----LQRRERAQQLQEE- 852

Query: 144 VNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQL 198
                    G  E    + R + Q    + RWQ + E+  R   L A   ++ QL
Sbjct: 853 -------EDGLQE-DQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQL 899



 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 59/198 (29%), Positives = 91/198 (45%), Gaps = 33/198 (16%)

Query: 26   LENQRRELEKLRAE------LEAERAGWRAERRRFAARERQLR-EEAERERRQLADR--- 75
            L  +R E +  R E      LE ++   + + R+F   E+QLR +E +++ RQ  DR   
Sbjct: 1563 LRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFR 1622

Query: 76   -----LRSKWEAQRSRELRQ---LQEEMQ---REREAEIRQLLRWKEAEQRQL------Q 118
                 L+ + E Q  R+ R    L+EE Q   +ERE ++R     K  E+ QL      Q
Sbjct: 1623 EDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQ 1682

Query: 119  QLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTD 178
            QL  +ERD   R+ RE ++QL  +   R              + + R +E   QLR +T+
Sbjct: 1683 QLRRQERD---RKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEE---QLRQETE 1736

Query: 179  GEQAARIRYLQAALEVER 196
             EQ  R    +  LE E+
Sbjct: 1737 QEQLRRQERYRKILEEEQ 1754



 Score = 48.9 bits (115), Expect = 4e-05
 Identities = 44/140 (31%), Positives = 66/140 (47%), Gaps = 26/140 (18%)

Query: 27  ENQRRELEKLRAELEAERAGW-----RAERRRFAARERQLREEAERERRQ---------- 71
           E +RR+ +  R + E  R  W        R +   RE+QLR E E  R Q          
Sbjct: 468 EQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEER 527

Query: 72  LADRLRSKWEAQRSRELRQLQ-----EEMQREREAEIRQLLRWKEAEQRQLQQLLHRERD 126
           L  RLRS+ + +R +E R+ Q     EE + E+E   R+  R K  ++ +  QLL RE +
Sbjct: 528 LQQRLRSEQQLRREQEERREQLLKREEEKRLEQE---RREQRLKREQEERRDQLLKREEE 584

Query: 127 GVVRQARELQRQLAEELVNR 146
              R+ + L+R+  E L  R
Sbjct: 585 ---RRQQRLKREQEERLEQR 601



 Score = 48.5 bits (114), Expect = 5e-05
 Identities = 49/162 (30%), Positives = 76/162 (46%), Gaps = 21/162 (12%)

Query: 31   RELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELRQ 90
            RE E+L  E E ++   +   R+F   E+QLR + ER+R+     LRS+   ++  E  Q
Sbjct: 1464 REEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQ-ERDRKFREQELRSQEPERKFLEEEQ 1522

Query: 91   LQEEMQRERE--AEIRQLLRWKEAEQR------------QLQQLLHRERDGVVRQARELQ 136
                 QR+R+   E +QL R +  +QR            QL+Q   RE   + RQ R+ +
Sbjct: 1523 QLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQ--EREEQQLSRQERDRK 1580

Query: 137  RQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTD 178
             +L E+ V R    R    +    + + R QE   QLR + D
Sbjct: 1581 FRLEEQKVRRQEQERKFMED----EQQLRRQEGQQQLRQERD 1618



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 46/130 (35%), Positives = 68/130 (52%), Gaps = 18/130 (13%)

Query: 27  ENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAER-ERRQLA-------DRLRS 78
           E Q+RE   L  E E E+   R  +RR   +E Q  EE E+ +RR+ A       D L+ 
Sbjct: 802 ERQQREQRFLPEEEEKEQ---RRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQE 858

Query: 79  KWEAQRSRELRQLQE---EMQREREAEIRQLLRWKEAEQRQL---QQLLHRERDGVVRQA 132
             E +RS+E R+ Q+   +++ ER+   R  L  K A Q QL   QQLL  E + + R+ 
Sbjct: 859 DQERRRSQEQRRDQKWRWQLEEERKRR-RHTLYAKPALQEQLRKEQQLLQEEEEELQREE 917

Query: 133 RELQRQLAEE 142
           RE +R+  +E
Sbjct: 918 REKRRRQEQE 927



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 33/100 (33%), Positives = 51/100 (51%), Gaps = 8/100 (8%)

Query: 50  ERRRFAARERQLREEA---ERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQL 106
           ++RRF  R+RQL EE     R++RQ  +R  ++ E Q  ++ R  Q + QR  E   RQ 
Sbjct: 118 DQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQR 177

Query: 107 LRWKEAEQR-----QLQQLLHRERDGVVRQARELQRQLAE 141
             W+E E+R     QLQ     E +    + +  +R+L E
Sbjct: 178 QEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLE 217



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 49/176 (27%), Positives = 77/176 (43%), Gaps = 9/176 (5%)

Query: 27  ENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERR-----QLADRLRSKWE 81
           E Q R  ++LR E +  R   +  R +   RE+QLR E E ER      Q     R K E
Sbjct: 392 EQQLRREQQLRREQQLRREQ-QLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKRE 450

Query: 82  AQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAE 141
            +  R+  + +EE +R  +   +Q L+  + E+R+ + L   E +   +Q R  ++QL  
Sbjct: 451 QEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERR-EQQLRR 509

Query: 142 ELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQ 197
           E   R         E    Q R R ++ L   R Q +  +    R  +  LE ER+
Sbjct: 510 EQEERREQRLKRQEEEERLQQRLRSEQQLR--REQEERREQLLKREEEKRLEQERR 563



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 41/132 (31%), Positives = 64/132 (48%), Gaps = 16/132 (12%)

Query: 27  ENQRRELEKLRAELEAERAG--------------WRAERRRFAARERQL-REEAERERRQ 71
           + QRR+ +K R +LE ER                 R E++     E +L REE E+ RRQ
Sbjct: 866 QEQRRD-QKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQ 924

Query: 72  LADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQ 131
             +R   + E  +  E + L+EE ++ R  E  +  R  +  Q++ +QLL  E +   RQ
Sbjct: 925 EQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQ 984

Query: 132 ARELQRQLAEEL 143
            RE + +  EEL
Sbjct: 985 EREKKYREEEEL 996



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 39/152 (25%), Positives = 73/152 (48%), Gaps = 28/152 (18%)

Query: 26   LENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSK------ 79
            LE Q RE E+L+ E E      + +RR+   RERQ REE E +R++   R R +      
Sbjct: 1166 LERQYREEEELQQEEEQLLREEQEKRRQ--ERERQYREEEELQRQKRKQRYRDEDQRSDL 1223

Query: 80   ---WEAQR---------------SRELRQLQEEMQREREA--EIRQLLRWKEAEQRQLQQ 119
               WE ++               + + RQL++   R+R++  +++ LL  ++   R+ ++
Sbjct: 1224 KWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQER 1283

Query: 120  LLHRERDGVVRQARELQRQLAEELVNRGHCSR 151
               ++RD    +  +L+R+  +E   R   S+
Sbjct: 1284 RRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQ 1315



 Score = 44.7 bits (104), Expect = 8e-04
 Identities = 42/129 (32%), Positives = 66/129 (51%), Gaps = 6/129 (4%)

Query: 24  AVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAE-RERRQLADRLRSKWEA 82
           ++L+++R+E ++ R E    +      +RR   R+ Q RE AE  E+ +  +RL  +   
Sbjct: 108 SLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQ 167

Query: 83  QRSREL-RQLQEEMQR-EREAEIRQLLRWKEAEQRQL---QQLLHRERDGVVRQARELQR 137
           +R  EL RQ QE  +R ER AE  QL   K  E  +    +QL  RE   + R+ RE ++
Sbjct: 168 RRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQ 227

Query: 138 QLAEELVNR 146
           Q   E  +R
Sbjct: 228 QQRRERQDR 236



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 40/149 (26%), Positives = 69/149 (46%), Gaps = 14/149 (9%)

Query: 29   QRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSREL 88
            Q RE ++LR +    +  W  E+ +   +E++LR+E +R+ R  A+   +  E  R  E 
Sbjct: 1805 QEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYR--AEEQFATQEKSRREEQ 1862

Query: 89   RQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVNRGH 148
               QEE Q+ R+   R+ LR +   ++Q ++  H       RQ  E++ Q   E    G 
Sbjct: 1863 ELWQEEEQKRRQERERK-LREEHIRRQQKEEQRH-------RQVGEIKSQ---EGKGHGR 1911

Query: 149  CSRPGASEVSAAQCRCR-LQEVLAQLRWQ 176
               PG  + ++   R   L E + + R Q
Sbjct: 1912 LLEPGTHQFASVPVRSSPLYEYIQEQRSQ 1940



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 49/181 (27%), Positives = 84/181 (46%), Gaps = 27/181 (14%)

Query: 27   ENQRRELEKLRAELEAERAGWRAERRR----------FAARERQLREEAERERRQLADRL 76
            E + R  E+ R  LE E+   R ER R             RE+QLR++ +R+ R+   +L
Sbjct: 1364 EEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQL 1423

Query: 77   RSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQ 136
              +   +R R+ R  +EE Q  R+   R+ L     E++QL+Q  HR+     R+  +L 
Sbjct: 1424 SRQ---ERDRKFR--EEEQQVRRQERERKFLE----EEQQLRQERHRK----FREEEQLL 1470

Query: 137  RQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVER 196
            ++  E+ ++R    R    E    + + R QE   + R Q    Q    ++L+   ++ R
Sbjct: 1471 QEREEQQLHRQERDRKFLEE----EQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHR 1526

Query: 197  Q 197
            Q
Sbjct: 1527 Q 1527



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 39/134 (29%), Positives = 62/134 (46%), Gaps = 7/134 (5%)

Query: 50   ERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRE-LRQLQEEMQREREAEIRQLLR 108
            ERRR+  R+R   EE + ER +  +  R   ++Q  ++ LR+ +EE +R +E + +    
Sbjct: 1282 ERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREE 1341

Query: 109  WKEAEQRQLQQLLHRERDGVVRQA----RELQRQLAEELVNRGHCSRPGASEVSAAQCRC 164
             +  ++R+ Q L  +ERD   R+     +E  R+  EE        R         Q RC
Sbjct: 1342 EQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRC 1401

Query: 165  RLQEVLAQLRWQTD 178
              QE   QLR   D
Sbjct: 1402 --QEREQQLRQDRD 1413



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 41/139 (29%), Positives = 63/139 (45%), Gaps = 16/139 (11%)

Query: 27   ENQRRELEKLRAELEAERAGWRAERRRFAARE--RQLREE----AERERRQLADRLRS-- 78
            E Q R  E+ R   E E+     E ++  ++E  R+ REE     ERE +QL  + R   
Sbjct: 1761 EQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGK 1820

Query: 79   -KWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQR 137
             +WE     E  QL+E+ QR R+   RQ   ++  EQ   Q+   RE   + ++  + +R
Sbjct: 1821 YRWE----EEQLQLEEQEQRLRQERDRQ---YRAEEQFATQEKSRREEQELWQEEEQKRR 1873

Query: 138  QLAEELVNRGHCSRPGASE 156
            Q  E  +   H  R    E
Sbjct: 1874 QERERKLREEHIRRQQKEE 1892



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 46/159 (28%), Positives = 76/159 (47%), Gaps = 13/159 (8%)

Query: 27  ENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQR-S 85
           E +RR+ + L++E + ER   +  R +   RE++L+ E E ER  L  RL+ + E +R  
Sbjct: 626 EEERRQ-QLLKSEEQEERRQQQLRREQQERREQRLKREEEEER--LEQRLKREHEEERRE 682

Query: 86  RELRQLQEEMQREREAEIRQLLRWK---EAEQRQLQQLLHRERDGVVRQARELQRQLAEE 142
           +EL + ++E  RER        +W+   EA+ RQ  ++  R R    +Q  + +RQ  EE
Sbjct: 683 QELAEEEQEQARERIKSRIPKWQWQLESEADARQ-SKVYSRPR----KQEGQRRRQEQEE 737

Query: 143 LVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQ 181
              R   S     E   A  + + +E      WQ   E+
Sbjct: 738 KRRRRE-SELQWQEEERAHRQQQEEEQRRDFTWQWQAEE 775



 Score = 42.4 bits (98), Expect = 0.004
 Identities = 41/133 (30%), Positives = 64/133 (48%), Gaps = 17/133 (12%)

Query: 27  ENQRRELEKLRAELEA-ERAGWRAERRRFAARERQLREEAER-ERRQLADRLRS------ 78
           + Q REL +   + E  ER   R  +RR     RQ +E  ER ERR   ++L+S      
Sbjct: 142 QEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHET 201

Query: 79  ----KWEAQRSRELRQL-----QEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVV 129
                 E  R REL +L     +E+ Q+ RE + R     +E E R+ + +L +E + + 
Sbjct: 202 EEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQ 261

Query: 130 RQARELQRQLAEE 142
            +  + QR+L EE
Sbjct: 262 EEEPQRQRELQEE 274



 Score = 42.4 bits (98), Expect = 0.004
 Identities = 45/173 (26%), Positives = 80/173 (46%), Gaps = 16/173 (9%)

Query: 27   ENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLAD----RLRSKWEA 82
            E +R+ LE+ +   +     +R E +    RE Q     ER+R+ L +    R + +   
Sbjct: 1443 ERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRK 1502

Query: 83   QRSRELRQ-------LQEEMQREREAEIRQLLRWKEAEQRQLQ-QLLHRERDGVVRQARE 134
             R +ELR        L+EE Q  R+   R+ L+ ++  +RQ + Q   ++RD   R+  +
Sbjct: 1503 FREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQ 1562

Query: 135  LQRQLAEELVNRGHCSRPGASE---VSAAQCRCRLQEVLAQLRWQTDGEQAAR 184
            L+++  E+ ++R    R    E   V   +   +  E   QLR Q +G+Q  R
Sbjct: 1563 LRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQ-EGQQQLR 1614



 Score = 41.2 bits (95), Expect = 0.008
 Identities = 46/144 (31%), Positives = 63/144 (43%), Gaps = 29/144 (20%)

Query: 29  QRRELEKLRAELEAERAGWRAERRRFAARER------QLREEAERERRQLADRLRSKWEA 82
           QRRE EK    LE E    R ER +    E       Q R  ++ +RR    R + + E 
Sbjct: 823 QRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEER 882

Query: 83  QRSRE------------------LRQLQEEMQR-EREAEIRQLLRWKEAEQRQLQ----Q 119
           +R R                   L++ +EE+QR ERE   RQ    +  E+ QLQ    Q
Sbjct: 883 KRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQ 942

Query: 120 LLHRERDGVVRQARELQRQLAEEL 143
           LL  ER+   RQ RE Q +  ++L
Sbjct: 943 LLREEREKRRRQERERQYRKDKKL 966



 Score = 39.3 bits (90), Expect = 0.032
 Identities = 59/240 (24%), Positives = 102/240 (42%), Gaps = 35/240 (14%)

Query: 527 RLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERE--LDQRRREC 584
           RL+R+ + E  RLQ++L  +Q                EE R Q+L  E E  L+Q RRE 
Sbjct: 518 RLKRQEEEE--RLQQRLRSEQQ----------LRREQEERREQLLKREEEKRLEQERRE- 564

Query: 585 QELGTQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLG 644
           Q L  +    R +  + E + +   LK     E+  RL+ +   +++ E E  E      
Sbjct: 565 QRLKREQEERRDQLLKREEERRQQRLKR----EQEERLEQR---LKREEVERLEQEERRE 617

Query: 645 RACQERDASGLIAEQLLQQAARGQDRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPE 704
           +  +  +      +QLL+   + + RQQQL+R+ Q+         +E + L+ R     E
Sbjct: 618 QRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHE 677

Query: 705 QPWETSQMPESQVK------GSRRPKFHARPEDYA-------VSQPNRDIQEKREASLEE 751
           +     ++ E + +       SR PK+  + E  A        S+P +   ++R    EE
Sbjct: 678 EERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEE 737



 Score = 39.3 bits (90), Expect = 0.032
 Identities = 42/146 (28%), Positives = 70/146 (47%), Gaps = 26/146 (17%)

Query: 27   ENQRRELEKLRAELEAERAGWRAERRRFAARERQLREE--------AERERRQLADR-LR 77
            E +RR  ++       E    R E++    R+R+ +EE         E+ RRQ  DR  R
Sbjct: 1280 EQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFR 1339

Query: 78   SKWEAQRSRELRQL--QEEMQREREAEIR------------QLLRWKEAEQRQL---QQL 120
             + +  + RE + L  QE  ++ RE E+R            Q LR +E E++ L   QQL
Sbjct: 1340 EEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQL 1399

Query: 121  LHRERDGVVRQARELQRQLAEELVNR 146
              +ER+  +RQ R+ + +  E+ ++R
Sbjct: 1400 RCQEREQQLRQDRDRKFREEEQQLSR 1425



 Score = 37.4 bits (85), Expect = 0.12
 Identities = 52/243 (21%), Positives = 102/243 (41%), Gaps = 24/243 (9%)

Query: 523 RDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRR 582
           R+ +  + E + E  R +++L  +Q     W +   ++   E+ RR+   L+R+ ++ RR
Sbjct: 427 REQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQ-QLKRDQEEERR 485

Query: 583 ECQELGTQAAPARRRGEEAETQL----QAALLKNAWLAEENGRLQAKTDWVRKVEAENSE 638
           E + L  +    R + E  E QL    +    +     EE  RLQ +    +++  E  E
Sbjct: 486 E-RWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEE 544

Query: 639 VRGHLGRACQERDASGLIAEQLL---------QQAARGQDRQQQLQRDPQKALCDLHPSW 689
            R  L +  +E+       EQ L         Q   R ++R+QQ  +  Q+   +     
Sbjct: 545 RREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKR 604

Query: 690 KEIQALQCRPGHPPEQPWETSQMPESQVKGSRRPKF--HARPEDYAVSQPNRDIQEKREA 747
           +E++ L+       ++     ++   + +  RR +       E+    Q  R+ QE+RE 
Sbjct: 605 EEVERLE-------QEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQ 657

Query: 748 SLE 750
            L+
Sbjct: 658 RLK 660



 Score = 37.0 bits (84), Expect = 0.16
 Identities = 21/74 (28%), Positives = 36/74 (48%)

Query: 27   ENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSR 86
            E ++ +LE+    L  ER        +FA +E+  REE E  + +   R + +    R  
Sbjct: 1824 EEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREE 1883

Query: 87   ELRQLQEEMQRERE 100
             +R+ Q+E QR R+
Sbjct: 1884 HIRRQQKEEQRHRQ 1897



 Score = 35.8 bits (81), Expect = 0.35
 Identities = 49/217 (22%), Positives = 88/217 (40%), Gaps = 30/217 (13%)

Query: 561 ATCEEVRRQMLALERELDQRRRECQELGTQAAPARRRGEEAETQLQAALLKNAWLAEENG 620
           A C+     +    +E DQRR E ++   +  P +RR ++ + Q +  L +    +E+  
Sbjct: 101 ARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQ-ERELAEGEEQSEKQE 159

Query: 621 RLQ-------------AKTDWVRKVE--AENSEVRGHLGRACQE-RDASGLIAEQLLQQA 664
           RL+              + +W  + E  AE  +++   G   +E  D   L   +LL+  
Sbjct: 160 RLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELR 219

Query: 665 ARGQDRQQQLQRDPQKALC--DLHPSW--------KEIQALQCRPGHPPEQPWETSQMPE 714
            +G++ +QQ +R+ Q  +   +    W        KE + LQ      P++  E  +  E
Sbjct: 220 RKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQ---EEEPQRQRELQEEEE 276

Query: 715 SQVKGSRRPKFHARPEDYAVSQPNRDIQEKREASLEE 751
              K  R+     R E+    Q  R  Q+ R    EE
Sbjct: 277 QLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEE 313



 Score = 35.8 bits (81), Expect = 0.35
 Identities = 89/388 (22%), Positives = 154/388 (39%), Gaps = 56/388 (14%)

Query: 385  WVLARRCYTLQEENKQLRRAGCPYQADEKVKRLKVKRAELTGLARRLADR--ARELQETN 442
            W    R +  Q+E +Q R     +QA+EK +R +          +RL+ R   RE +E  
Sbjct: 748  WQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGR----------QRLSARPPLREQRERQ 797

Query: 443  LRAVSAPIPGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQECHLLQARVAS 502
            LRA       +     E  +   R++ R+          ++K+++ L +E   LQ R  +
Sbjct: 798  LRAEERQQREQRFLPEEEEKEQRRRQRRE----------REKELQFLEEE-EQLQRRERA 846

Query: 503  GPCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSAT 562
                +   G      Q    R   + QR  Q+   +L+ +   ++    A P      A 
Sbjct: 847  QQLQEEEDG-----LQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKP------AL 895

Query: 563  CEEVRRQMLALERELDQRRRECQELGTQAAPARRRGEEAETQLQAALLKNAWLAEENGRL 622
             E++R++   L+ E ++ +RE +E   +    R+  EE + Q +   L       E  R 
Sbjct: 896  QEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLRE--EREKRRR 953

Query: 623  QAKTDWVRKVEAENSEVRGHLG-----RACQERDASGLIAEQLLQQ------AARGQDRQ 671
            Q +    RK +    +    LG     R  QER+      E+L Q+        R + R+
Sbjct: 954  QERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRR 1013

Query: 672  QQLQR------DPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKGSRRPKF 725
            Q+ +R      + Q+    L    +E + LQ R     E+  E  Q  E Q+ G  R + 
Sbjct: 1014 QEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREE--EELQQEEEQLLGEER-ET 1070

Query: 726  HARPEDYAVSQPNRDIQEKREASLEESP 753
              R E     +   ++Q++ E  L E P
Sbjct: 1071 RRRQELERQYRKEEELQQEEEQLLREEP 1098



 Score = 35.4 bits (80), Expect = 0.46
 Identities = 54/239 (22%), Positives = 96/239 (40%), Gaps = 31/239 (12%)

Query: 523  RDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRR- 581
            ++L+R  RE + EV + + QL+ ++       E   Q    EE++++   L RE  ++R 
Sbjct: 1134 QELERQYREEE-EVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRR 1192

Query: 582  -------RECQELGTQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEA 634
                   RE +EL  Q    R R E+  + L+       W  E       + + V     
Sbjct: 1193 QERERQYREEEELQRQKRKQRYRDEDQRSDLK-------WQWEPEKENAVRDNKVYCKGR 1245

Query: 635  ENSEVR----GHLGRACQERDASGLIAEQLLQQAARGQDRQQQLQRDPQKALCDLHPSWK 690
            EN + R      L     ++D   L+ EQ  Q+  R Q+R++  QRD           + 
Sbjct: 1246 ENEQFRQLEDSQLRDRQSQQDLQHLLGEQ--QERDREQERRRWQQRDRH---------FP 1294

Query: 691  EIQALQCRPGHPPEQPWETSQMPESQVKGSRRPKFHARPEDYAVSQPNRDIQEKREASL 749
            E + L+       ++    SQ  +  ++  R  K   +  D    +  + +QE+ E  L
Sbjct: 1295 EEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPL 1353



 Score = 35.4 bits (80), Expect = 0.46
 Identities = 83/377 (22%), Positives = 152/377 (40%), Gaps = 64/377 (16%)

Query: 396  EENKQLRRAGCPYQA----DEKVK---RLKVKRAELTGLARRLADRARELQETNLRAVSA 448
            +E +QLRR     Q     D K +   +L+ +R E   L+R+  DR   L+E  +R    
Sbjct: 1535 QEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQ-LSRQERDRKFRLEEQKVRRQE- 1592

Query: 449  PIPGESCAGLELCQVFARQRARD-LSEQASAPLAKDKQIEELRQECHLLQARVASGPCSD 507
                +    +E  Q   RQ  +  L ++      +D+Q+ + R+E               
Sbjct: 1593 ----QERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREE--------------- 1633

Query: 508  LHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVR 567
                      Q L+ ++ DR   E + ++ R +R+  L+      + E   +    +E  
Sbjct: 1634 ----------QQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFRE---EEQLLQEGE 1680

Query: 568  RQMLALERELDQRRRECQELGTQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTD 627
             Q L  +    + R E Q+L  Q     R+  + E QL+   L+  +  EE  R + + +
Sbjct: 1681 EQQLRRQERDRKFREEEQQLRRQER--ERKFLQEEQQLRRQELERKFREEEQLRQETEQE 1738

Query: 628  WVRKVEA-----ENSEVRGHLGRAC---QERDASGLIAEQLLQQAARGQDRQQQLQRDPQ 679
             +R+ E      E  ++R          QERD      EQL Q+    ++ QQ   ++  
Sbjct: 1739 QLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQE----REEQQLRSQESD 1794

Query: 680  KALCDLHPSWKEIQALQCRP-GHPPEQPWETSQM----PESQVKGSRRPKFHARPEDYAV 734
            +   +     +E +  Q RP     +  WE  Q+     E +++  R  ++ A  E +A 
Sbjct: 1795 RKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAE-EQFAT 1853

Query: 735  SQPNRDIQEKREASLEE 751
             + +R  +E++E   EE
Sbjct: 1854 QEKSR--REEQELWQEE 1868



 Score = 35.0 bits (79), Expect = 0.60
 Identities = 40/157 (25%), Positives = 68/157 (43%), Gaps = 14/157 (8%)

Query: 525 LDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRREC 584
           L++  R+ + E L  QRQ   ++    A  E   Q  +C+    +    E +L  RRRE 
Sbjct: 161 LEQRDRQRRDEELWRQRQEWQEREERRAEEE---QLQSCKGHETEEFPDEEQL--RRREL 215

Query: 585 QELGTQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLG 644
            EL       RR+G E + Q +       +  EE    + +   +RK E +  E      
Sbjct: 216 LEL-------RRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQ 268

Query: 645 RACQERDAS--GLIAEQLLQQAARGQDRQQQLQRDPQ 679
           R  QE +     L  ++L ++    + +QQ+L+R+ Q
Sbjct: 269 RELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQ 305



 Score = 34.7 bits (78), Expect = 0.78
 Identities = 73/330 (22%), Positives = 130/330 (39%), Gaps = 39/330 (11%)

Query: 462  QVFARQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPCSDLHTGRGGPCTQWLN 521
            Q+  ++R R   E+      ++++ + L +E  L Q R       +          Q L 
Sbjct: 1422 QLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEE----------QLLQ 1471

Query: 522  VRDLDRLQR-ESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQR 580
             R+  +L R E  R+ L  ++QL  Q+ +     +   Q    +E  R+ L  E++L ++
Sbjct: 1472 EREEQQLHRQERDRKFLEEEQQLRRQERDR----KFREQELRSQEPERKFLEEEQQLHRQ 1527

Query: 581  RREC-----------QELGTQAAPARRRGEEAETQLQAALLKNAWLAEENGR-LQAKTDW 628
            +R+            QE G Q    R R    E QL+    +     +E  R  + +   
Sbjct: 1528 QRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQK 1587

Query: 629  VRKVEAENS------EVRGHLGRAC--QERDASGLIAEQLLQQAARGQDRQQQLQRDPQK 680
            VR+ E E        ++R   G+    QERD      EQLLQ+    Q  +Q+  R   +
Sbjct: 1588 VRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLE 1647

Query: 681  ALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKGSRRPKFHARPEDYAVSQPNRD 740
                L    +E Q    R     E+     +  E Q++   R +   R E+  + +  R+
Sbjct: 1648 EEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDR-KFREEEQQLRRQERE 1706

Query: 741  ---IQEKREASLEESPVALGESASVPQVSE 767
               +QE+++   +E      E   + Q +E
Sbjct: 1707 RKFLQEEQQLRRQELERKFREEEQLRQETE 1736



 Score = 33.1 bits (74), Expect = 2.3
 Identities = 54/229 (23%), Positives = 97/229 (42%), Gaps = 30/229 (13%)

Query: 395  QEENKQLRRAGCPYQADEKVKRLKVKRAELTGLARRLADRARELQETNLRAVSA--PIPG 452
            +EE +QLRR     +  ++ ++L+  R EL    R      +E ++  LR       I  
Sbjct: 1694 REEEQQLRRQERERKFLQEEQQLR--RQELERKFREEEQLRQETEQEQLRRQERYRKILE 1751

Query: 453  ESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELR---------QECHLLQARVASG 503
            E     E  +   R++ RD   +    L ++++ ++LR         +E  L Q R    
Sbjct: 1752 EEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQ 1811

Query: 504  PCSDLHTGRGGPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATC 563
                   G+     +W    + ++LQ E Q + LR +R    +         A  Q AT 
Sbjct: 1812 LRPQQRDGK----YRW----EEEQLQLEEQEQRLRQERDRQYR---------AEEQFATQ 1854

Query: 564  EEVRRQMLALERELDQRRRECQELGTQAAPARRRGEEAETQLQAALLKN 612
            E+ RR+   L +E +Q+RR+ +E   +    RR+ +E +   Q   +K+
Sbjct: 1855 EKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKS 1903



 Score = 31.6 bits (70), Expect = 6.6
 Identities = 38/132 (28%), Positives = 64/132 (48%), Gaps = 23/132 (17%)

Query: 27   ENQRRELEKLRAELEAERAGWRAERRRFAARE----RQLREEAERERRQLAD---RLRSK 79
            E+QR +L K + E E E A  R  +     RE    RQL +   R+R+   D    L  +
Sbjct: 1217 EDQRSDL-KWQWEPEKENAV-RDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQ 1274

Query: 80   WEAQRSRELRQLQ---------EEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVR 130
             E  R +E R+ Q         E+++RE + E ++    ++ + ++ +QLL  ER+   R
Sbjct: 1275 QERDREQERRRWQQRDRHFPEEEQLEREEQKEAKR----RDRKSQEEKQLLREERE-EKR 1329

Query: 131  QARELQRQLAEE 142
            + +E  R+  EE
Sbjct: 1330 RRQETDRKFREE 1341



 Score = 31.6 bits (70), Expect = 6.6
 Identities = 36/158 (22%), Positives = 65/158 (41%), Gaps = 16/158 (10%)

Query: 523  RDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRR- 581
            +D DR  RE ++++ R +R    ++           Q    +E  R+ L  E++L Q R 
Sbjct: 1410 QDRDRKFREEEQQLSRQERDRKFREEE---------QQVRRQERERKFLEEEQQLRQERH 1460

Query: 582  ---RECQELGTQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSE 638
               RE ++L  +    +   +E + +    L +   L  +    + +   +R  E E   
Sbjct: 1461 RKFREEEQLLQEREEQQLHRQERDRKF---LEEEQQLRRQERDRKFREQELRSQEPERKF 1517

Query: 639  VRGHLGRACQERDASGLIAEQLLQQAARGQDRQQQLQR 676
            +        Q+R    L  EQ L++  RGQ R+Q   R
Sbjct: 1518 LEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDR 1555



 Score = 31.2 bits (69), Expect = 8.6
 Identities = 47/159 (29%), Positives = 66/159 (41%), Gaps = 28/159 (17%)

Query: 530 RESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEVRRQMLALERELDQRRRECQELGT 589
           R+ +R+ LR +RQ   QQ           +    +++RR+     RE  + RRE QE   
Sbjct: 279 RKLERQELRRERQEEEQQQQ---------RLRREQQLRRKQEEERREQQEERREQQERRE 329

Query: 590 QAAPAR----RRGEEAETQLQAALLKNAWLAEENGRLQAKTDWVRKVEAENSEVRGHLGR 645
           Q    R    RR +E   + Q        L  E    + +    R+ E E  E +  L R
Sbjct: 330 QQEERREQQLRREQEERREQQ--------LRREQEEERREQQLRREQEEERREQQ--LRR 379

Query: 646 ACQERDASGLIAEQLL---QQAARGQD--RQQQLQRDPQ 679
             Q R    L  EQ L   QQ  R Q   R+QQL+R+ Q
Sbjct: 380 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ 418


>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
           sapiens]
          Length = 1297

 Score = 58.2 bits (139), Expect = 7e-08
 Identities = 47/130 (36%), Positives = 68/130 (52%), Gaps = 19/130 (14%)

Query: 26  LENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRS 85
           LE Q+RE E+ + +L AER      ++R   ++ Q R   E++RR+   R + + E +R 
Sbjct: 373 LEQQQRENEEHKRQLLAER------QKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRH 426

Query: 86  RELRQLQEEMQREREAEIRQLLRWKEAEQRQL----QQLLH---------RERDGVVRQA 132
            E +  +EE +R  E E   + R  E EQRQL    QQLLH         R++    RQA
Sbjct: 427 YEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQA 486

Query: 133 RELQRQLAEE 142
             LQRQL +E
Sbjct: 487 ERLQRQLKQE 496



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 42/135 (31%), Positives = 71/135 (52%), Gaps = 11/135 (8%)

Query: 69  RRQLADRLRSKWEAQRSRELRQLQ---EEMQREREAEIRQLLRWKEAEQRQLQQLLHRER 125
           R QLA++ RS  EA R ++L Q Q   EE +R+  AE ++ +  ++ ++R+L++   RE+
Sbjct: 356 RLQLANKERS--EALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREK 413

Query: 126 DGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQ---LRWQTDGEQA 182
           +   +Q RE +R   E++       R   +E      R +L+E   Q   L+ Q   EQA
Sbjct: 414 ELRKQQEREQRRHYEEQMRREEERRR---AEHEQEYIRRQLEEEQRQLEILQQQLLHEQA 470

Query: 183 ARIRYLQAALEVERQ 197
             + Y +  LE +RQ
Sbjct: 471 LLLEYKRKQLEEQRQ 485


>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
           sapiens]
          Length = 1305

 Score = 58.2 bits (139), Expect = 7e-08
 Identities = 47/130 (36%), Positives = 68/130 (52%), Gaps = 19/130 (14%)

Query: 26  LENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRS 85
           LE Q+RE E+ + +L AER      ++R   ++ Q R   E++RR+   R + + E +R 
Sbjct: 373 LEQQQRENEEHKRQLLAER------QKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRH 426

Query: 86  RELRQLQEEMQREREAEIRQLLRWKEAEQRQL----QQLLH---------RERDGVVRQA 132
            E +  +EE +R  E E   + R  E EQRQL    QQLLH         R++    RQA
Sbjct: 427 YEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQA 486

Query: 133 RELQRQLAEE 142
             LQRQL +E
Sbjct: 487 ERLQRQLKQE 496



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 42/135 (31%), Positives = 71/135 (52%), Gaps = 11/135 (8%)

Query: 69  RRQLADRLRSKWEAQRSRELRQLQ---EEMQREREAEIRQLLRWKEAEQRQLQQLLHRER 125
           R QLA++ RS  EA R ++L Q Q   EE +R+  AE ++ +  ++ ++R+L++   RE+
Sbjct: 356 RLQLANKERS--EALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREK 413

Query: 126 DGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQ---LRWQTDGEQA 182
           +   +Q RE +R   E++       R   +E      R +L+E   Q   L+ Q   EQA
Sbjct: 414 ELRKQQEREQRRHYEEQMRREEERRR---AEHEQEYIRRQLEEEQRQLEILQQQLLHEQA 470

Query: 183 ARIRYLQAALEVERQ 197
             + Y +  LE +RQ
Sbjct: 471 LLLEYKRKQLEEQRQ 485


>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
           sapiens]
          Length = 1352

 Score = 58.2 bits (139), Expect = 7e-08
 Identities = 47/130 (36%), Positives = 68/130 (52%), Gaps = 19/130 (14%)

Query: 26  LENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRS 85
           LE Q+RE E+ + +L AER      ++R   ++ Q R   E++RR+   R + + E +R 
Sbjct: 373 LEQQQRENEEHKRQLLAER------QKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRH 426

Query: 86  RELRQLQEEMQREREAEIRQLLRWKEAEQRQL----QQLLH---------RERDGVVRQA 132
            E +  +EE +R  E E   + R  E EQRQL    QQLLH         R++    RQA
Sbjct: 427 YEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQA 486

Query: 133 RELQRQLAEE 142
             LQRQL +E
Sbjct: 487 ERLQRQLKQE 496



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 42/135 (31%), Positives = 71/135 (52%), Gaps = 11/135 (8%)

Query: 69  RRQLADRLRSKWEAQRSRELRQLQ---EEMQREREAEIRQLLRWKEAEQRQLQQLLHRER 125
           R QLA++ RS  EA R ++L Q Q   EE +R+  AE ++ +  ++ ++R+L++   RE+
Sbjct: 356 RLQLANKERS--EALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREK 413

Query: 126 DGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQ---LRWQTDGEQA 182
           +   +Q RE +R   E++       R   +E      R +L+E   Q   L+ Q   EQA
Sbjct: 414 ELRKQQEREQRRHYEEQMRREEERRR---AEHEQEYIRRQLEEEQRQLEILQQQLLHEQA 470

Query: 183 ARIRYLQAALEVERQ 197
             + Y +  LE +RQ
Sbjct: 471 LLLEYKRKQLEEQRQ 485



 Score = 39.3 bits (90), Expect = 0.032
 Identities = 38/131 (29%), Positives = 61/131 (46%), Gaps = 12/131 (9%)

Query: 27  ENQRRELEKLRAELEAE--RAGWRAERRRFAARERQLREEA----ERERRQL-----ADR 75
           E  RRE E+ RAE E E  R     E+R+    ++QL  E     E +R+QL     A+R
Sbjct: 429 EQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAER 488

Query: 76  LRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQAREL 135
           L+ + + +R   L  LQ + Q +R  E + L  +KE      +    +E +   R  R+ 
Sbjct: 489 LQRQLKQERDY-LVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQS 547

Query: 136 QRQLAEELVNR 146
              +  ++ NR
Sbjct: 548 SPAMPHKVANR 558


>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
           sapiens]
          Length = 1360

 Score = 58.2 bits (139), Expect = 7e-08
 Identities = 47/130 (36%), Positives = 68/130 (52%), Gaps = 19/130 (14%)

Query: 26  LENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRS 85
           LE Q+RE E+ + +L AER      ++R   ++ Q R   E++RR+   R + + E +R 
Sbjct: 373 LEQQQRENEEHKRQLLAER------QKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRH 426

Query: 86  RELRQLQEEMQREREAEIRQLLRWKEAEQRQL----QQLLH---------RERDGVVRQA 132
            E +  +EE +R  E E   + R  E EQRQL    QQLLH         R++    RQA
Sbjct: 427 YEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQA 486

Query: 133 RELQRQLAEE 142
             LQRQL +E
Sbjct: 487 ERLQRQLKQE 496



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 42/135 (31%), Positives = 71/135 (52%), Gaps = 11/135 (8%)

Query: 69  RRQLADRLRSKWEAQRSRELRQLQ---EEMQREREAEIRQLLRWKEAEQRQLQQLLHRER 125
           R QLA++ RS  EA R ++L Q Q   EE +R+  AE ++ +  ++ ++R+L++   RE+
Sbjct: 356 RLQLANKERS--EALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREK 413

Query: 126 DGVVRQARELQRQLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQ---LRWQTDGEQA 182
           +   +Q RE +R   E++       R   +E      R +L+E   Q   L+ Q   EQA
Sbjct: 414 ELRKQQEREQRRHYEEQMRREEERRR---AEHEQEYIRRQLEEEQRQLEILQQQLLHEQA 470

Query: 183 ARIRYLQAALEVERQ 197
             + Y +  LE +RQ
Sbjct: 471 LLLEYKRKQLEEQRQ 485



 Score = 39.3 bits (90), Expect = 0.032
 Identities = 38/131 (29%), Positives = 61/131 (46%), Gaps = 12/131 (9%)

Query: 27  ENQRRELEKLRAELEAE--RAGWRAERRRFAARERQLREEA----ERERRQL-----ADR 75
           E  RRE E+ RAE E E  R     E+R+    ++QL  E     E +R+QL     A+R
Sbjct: 429 EQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAER 488

Query: 76  LRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVRQAREL 135
           L+ + + +R   L  LQ + Q +R  E + L  +KE      +    +E +   R  R+ 
Sbjct: 489 LQRQLKQERDY-LVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQS 547

Query: 136 QRQLAEELVNR 146
              +  ++ NR
Sbjct: 548 SPAMPHKVANR 558


>gi|41152097 DNA segment on chromosome X and Y (unique) 155
           expressed sequence isoform 1 [Homo sapiens]
          Length = 695

 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 98/363 (26%), Positives = 144/363 (39%), Gaps = 64/363 (17%)

Query: 11  ASPKKPGCSSPAAAVLENQRRELEKLRAELEAERAGWRAERRRFAARERQLREEAERERR 70
           AS KK          LE QR E +  R E EAE      ER+R   R+++  EE ERER+
Sbjct: 266 ASIKKRQLERQKLQELEQQREEQK--RREKEAE------ERQRAEERKQKELEELERERK 317

Query: 71  QLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQLLRWKEAEQRQLQQLLHRERDGVVR 130
           +  ++LR + + QR RELR+ Q+++++  +AE          EQ+QLQ+ +  E   ++ 
Sbjct: 318 R-EEKLRKREQKQRDRELRRNQKKLEK-LQAE----------EQKQLQEKIKLEERKLLL 365

Query: 131 QARELQR-QLAEELVNRGHCSRPGASEVSAAQCRCRLQEVLAQLRWQTDGEQAARIRYLQ 189
             R LQ  +L  EL++R    +    E    + R + QE   +L       Q A +R ++
Sbjct: 366 AQRNLQSIRLIAELLSRAKAVKLREQEQKEEKLRLQQQEERRRL-------QEAELRRVE 418

Query: 190 AALEVERQLFLKYILAHFRGH---PALSGSPDPQAVH--------SLEEP---LPQTSSG 235
              E ER L L+      R       LS  PD    H         L +P   + QT S 
Sbjct: 419 E--EKERALGLQRKERELRERLLSILLSKKPDDSHTHDELGVAHADLLQPVLDILQTVSS 476

Query: 236 SCHAPKPACQLGSLDSLSAEVGVRSRSLGLVSSACSSSPDGLLSTHASSLDCFAPACSRS 295
            C +      LG      A             S      DG   +   S+   AP C   
Sbjct: 477 GCVSATTLHPLGGQPPAGAP----------KESPAHPEADGAPKSVNGSVAEEAP-CKEV 525

Query: 296 LDSTRSLPKASKSEERPSSPDTSTPGSRRLSPPPSPLPPPPPPSAHRKLSNPRGGEGSES 355
             S R +P+         SP+   PG      P +   P   P+  + +S  R    SE 
Sbjct: 526 QSSCRVVPE-------DGSPEKRCPGGVLSCIPDNNQQPKGIPACEQNVS--RKDTRSEQ 576

Query: 356 QPC 358
             C
Sbjct: 577 DKC 579



 Score = 33.5 bits (75), Expect = 1.7
 Identities = 23/77 (29%), Positives = 43/77 (55%), Gaps = 1/77 (1%)

Query: 64  EAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAEIRQL-LRWKEAEQRQLQQLLH 122
           +A  ++RQL  +   + E QR  + R+ +E  +R+R  E +Q  L   E E+++ ++L  
Sbjct: 265 DASIKKRQLERQKLQELEQQREEQKRREKEAEERQRAEERKQKELEELERERKREEKLRK 324

Query: 123 RERDGVVRQARELQRQL 139
           RE+    R+ R  Q++L
Sbjct: 325 REQKQRDRELRRNQKKL 341


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.131    0.394 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 74,497,607
Number of Sequences: 37866
Number of extensions: 4183118
Number of successful extensions: 40987
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 515
Number of HSP's successfully gapped in prelim test: 1222
Number of HSP's that attempted gapping in prelim test: 23395
Number of HSP's gapped (non-prelim): 11910
length of query: 1639
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1523
effective length of database: 13,855,062
effective search space: 21101259426
effective search space used: 21101259426
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.