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Search of human proteins with 191251777
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|191251777 breast carcinoma amplified sequence 1 [Homo
sapiens]
(584 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|191251777 breast carcinoma amplified sequence 1 [Homo sapiens] 1162 0.0
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 62 1e-09
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 59 2e-08
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 55 2e-07
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 54 4e-07
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 52 2e-06
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 52 2e-06
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f... 51 3e-06
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 51 3e-06
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ... 51 3e-06
gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1... 50 6e-06
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 49 1e-05
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 49 1e-05
gi|34335264 zinc finger, MYND-type containing 8 isoform c [Homo ... 48 2e-05
gi|34335262 zinc finger, MYND-type containing 8 isoform a [Homo ... 48 2e-05
gi|34335266 zinc finger, MYND-type containing 8 isoform b [Homo ... 48 2e-05
gi|212276104 leucine rich repeat (in FLII) interacting protein 1... 47 4e-05
gi|212276096 leucine rich repeat (in FLII) interacting protein 1... 47 4e-05
gi|212276070 leucine rich repeat (in FLII) interacting protein 1... 47 4e-05
gi|38788260 bromodomain PHD finger transcription factor isoform ... 47 6e-05
gi|104526627 triadin [Homo sapiens] 45 2e-04
gi|21493022 A kinase (PRKA) anchor protein 12 isoform 1 [Homo sa... 44 4e-04
gi|21493024 A kinase (PRKA) anchor protein 12 isoform 2 [Homo sa... 44 4e-04
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ... 44 5e-04
gi|225543215 antigen identified by monoclonal antibody Ki-67 iso... 43 7e-04
gi|103472005 antigen identified by monoclonal antibody Ki-67 iso... 43 7e-04
gi|169658378 trinucleotide repeat containing 18 [Homo sapiens] 43 7e-04
gi|55741677 SET domain containing 1A [Homo sapiens] 43 0.001
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 43 0.001
gi|4503257 death-domain associated protein isoform a [Homo sapiens] 42 0.001
>gi|191251777 breast carcinoma amplified sequence 1 [Homo sapiens]
Length = 584
Score = 1162 bits (3006), Expect = 0.0
Identities = 584/584 (100%), Positives = 584/584 (100%)
Query: 1 MGNQMSVPQRVEDQENEPEAETYQDNASALNGVPVVVSTHTVQHLEEVDLGISVKTDNVA 60
MGNQMSVPQRVEDQENEPEAETYQDNASALNGVPVVVSTHTVQHLEEVDLGISVKTDNVA
Sbjct: 1 MGNQMSVPQRVEDQENEPEAETYQDNASALNGVPVVVSTHTVQHLEEVDLGISVKTDNVA 60
Query: 61 TSSPETTEISAVADANGKNLGKEAKPEAPAAKSRFFLMLSRPVPGRTGDQAADSSLGSVK 120
TSSPETTEISAVADANGKNLGKEAKPEAPAAKSRFFLMLSRPVPGRTGDQAADSSLGSVK
Sbjct: 61 TSSPETTEISAVADANGKNLGKEAKPEAPAAKSRFFLMLSRPVPGRTGDQAADSSLGSVK 120
Query: 121 LDVSSNKAPANKDPSESWTLPVAAGPGQDTDKTPGHAPAQDKVLSAARDPTLLPPETGGA 180
LDVSSNKAPANKDPSESWTLPVAAGPGQDTDKTPGHAPAQDKVLSAARDPTLLPPETGGA
Sbjct: 121 LDVSSNKAPANKDPSESWTLPVAAGPGQDTDKTPGHAPAQDKVLSAARDPTLLPPETGGA 180
Query: 181 GGEAPSKPKDSSFFDKFFKLDKGQEKVPGDSQQEAKRAEHQDKVDEVPGLSGQSDDVPAG 240
GGEAPSKPKDSSFFDKFFKLDKGQEKVPGDSQQEAKRAEHQDKVDEVPGLSGQSDDVPAG
Sbjct: 181 GGEAPSKPKDSSFFDKFFKLDKGQEKVPGDSQQEAKRAEHQDKVDEVPGLSGQSDDVPAG 240
Query: 241 KDIVDGKEKEGQELGTADCSVPGDPEGLETAKDDSQAAAIAENNNSIMSFFKTLVSPNKA 300
KDIVDGKEKEGQELGTADCSVPGDPEGLETAKDDSQAAAIAENNNSIMSFFKTLVSPNKA
Sbjct: 241 KDIVDGKEKEGQELGTADCSVPGDPEGLETAKDDSQAAAIAENNNSIMSFFKTLVSPNKA 300
Query: 301 ETKKDPEDTGAEKSPTTSADLKSDKANFTSQETQGAGKNSKGCNPSGHTQSVTTPEPAKE 360
ETKKDPEDTGAEKSPTTSADLKSDKANFTSQETQGAGKNSKGCNPSGHTQSVTTPEPAKE
Sbjct: 301 ETKKDPEDTGAEKSPTTSADLKSDKANFTSQETQGAGKNSKGCNPSGHTQSVTTPEPAKE 360
Query: 361 GTKEKSGPTSLPLGKLFWKKSVKEDSVPTGAEENVVCESPVEIIKSKEVESALQTVDLNE 420
GTKEKSGPTSLPLGKLFWKKSVKEDSVPTGAEENVVCESPVEIIKSKEVESALQTVDLNE
Sbjct: 361 GTKEKSGPTSLPLGKLFWKKSVKEDSVPTGAEENVVCESPVEIIKSKEVESALQTVDLNE 420
Query: 421 GDAAPEPTEAKLKREESKPRTSLMAFLRQMSVKGDGGITHSEEINGKDSSCQTSDSTEKT 480
GDAAPEPTEAKLKREESKPRTSLMAFLRQMSVKGDGGITHSEEINGKDSSCQTSDSTEKT
Sbjct: 421 GDAAPEPTEAKLKREESKPRTSLMAFLRQMSVKGDGGITHSEEINGKDSSCQTSDSTEKT 480
Query: 481 ITPPEPEPTGAPQKGKEGSSKDKKSAAEMNKQKSNKQEAKEPAQCTEQATVDTNSLQNGD 540
ITPPEPEPTGAPQKGKEGSSKDKKSAAEMNKQKSNKQEAKEPAQCTEQATVDTNSLQNGD
Sbjct: 481 ITPPEPEPTGAPQKGKEGSSKDKKSAAEMNKQKSNKQEAKEPAQCTEQATVDTNSLQNGD 540
Query: 541 KLQKRPEKRQQSLGGFFKGLGPKRMLDAQVQTDPVSIGPVGKSK 584
KLQKRPEKRQQSLGGFFKGLGPKRMLDAQVQTDPVSIGPVGKSK
Sbjct: 541 KLQKRPEKRQQSLGGFFKGLGPKRMLDAQVQTDPVSIGPVGKSK 584
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 62.0 bits (149), Expect = 1e-09
Identities = 124/567 (21%), Positives = 209/567 (36%), Gaps = 66/567 (11%)
Query: 32 GVPVV--VSTHTVQHLEEVDLGISVKTDNVATSSPETTEISAVADANGKNLGKEAKPEAP 89
G+P + VSTH EE + + K++ E TE + V + + KEAK E
Sbjct: 425 GLPKIPSVSTHIKVKSEE-KIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEG 483
Query: 90 AAKSRFFLMLSRPVPGRTGDQAADSSLGSVKLDVSSNKAPANKDPSESWTLPVAAGPGQD 149
+ + T A+ + K S K A K P+E A P ++
Sbjct: 484 KEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEA-KSPAE------AKSPEKE 536
Query: 150 TDKTPGHAPAQDKVLSAARDPTLLPPETGGAGGEAPSKPKDSSFFDKFFKLDKGQEKVPG 209
K+P + +K S A++ PPE E P + +K K + K P
Sbjct: 537 EAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPA 596
Query: 210 DSQQEAKRAEHQDKVDEVPGLSGQSDDVPAGKDIVDGKEKEGQELGTAD-------CSVP 262
+++ K A+ K + +S K + K E + T + P
Sbjct: 597 EAKSPEK-AKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSP 655
Query: 263 GDPEGLETAKDDSQAAAIAENNNSIMSFFKT-LVSPNKAET--KKDPEDTGAEKSPTTSA 319
E K S A A++ S K SP KA++ K++ + KSP
Sbjct: 656 EKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEE 715
Query: 320 DLKSDKANFTSQETQGAGKNSKGCNPSGHTQSVTTPEPAKEGTKEKSGPTSLPLGKLFWK 379
+KA +E + +K S + +PE AK K K+ P K K
Sbjct: 716 AKSPEKAKSPVKEEAKTPEKAK----SPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAK 771
Query: 380 KSVKE--DSVPTGAEENV--------VCESPV---------EIIKSKEVESAL------Q 414
+ + D P A+ V +SP+ EI K +EV+S + Q
Sbjct: 772 EEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQ 831
Query: 415 TVDLNE---------GDAAPEPTEAKLKREESKPRTSLMAFLRQMSVKGDGGITHSEEIN 465
V + E A P+ E K ++E P+ A ++ K + + +E
Sbjct: 832 EVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKE--APKPKVEEKKEPAVEKPKESK 889
Query: 466 GKDSSCQTSDSTEKTITPPEPEPTGAPQKGKEGSSKDKKSAAEMNKQKSNKQEAKEPAQC 525
+ + D +K + PE E AP K + K E+ K++ + +AKEP++
Sbjct: 890 VEAKKEEAED--KKKVPTPEKE---APAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKP 944
Query: 526 TEQATVDTNSLQNGDKLQKRPEKRQQS 552
E+ ++ K+PE++ ++
Sbjct: 945 AEKKEAAPEKKDTKEEKAKKPEEKPKT 971
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 58.5 bits (140), Expect = 2e-08
Identities = 98/491 (19%), Positives = 162/491 (32%), Gaps = 53/491 (10%)
Query: 109 DQAADSSLGSVKLDVSSNKAPANKDPSESWTLPVAAGPGQDTDKTPGHAPAQDKVLSAAR 168
D A S L + S K P K + A +D ++ A+
Sbjct: 44 DANASSLLDIYSFWLKSAKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAK 103
Query: 169 DPTLLPPETGGAGGEAPSKPKDSSFFDKFFKLDKGQEKVPGDSQQEAKRAEHQDKVDEVP 228
+ G G+A +K +SS ++ D +++ Q+ K K
Sbjct: 104 KAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKK 163
Query: 229 GLSGQSDDVPAGKDIVDGKEKEGQELGTADCSVPGDPEGLETAKDDSQAAAIAENNNSIM 288
S SD + +D +K T P+ A + A + +++S
Sbjct: 164 AKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSS 223
Query: 289 SFF-------KTLVSPNKAETKKDPEDTGAEKSPTTSADLKSDKANFTSQETQGAGKNSK 341
S K +P K KK K+ TT S + +S E + K K
Sbjct: 224 SSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMK 283
Query: 342 GCNPSGHTQSVTTPE------------PAKEGTKEKSGPTSLPLGKLFWKKSVKEDSVPT 389
N G SV P P K K++ +S S +E PT
Sbjct: 284 --NKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPT 341
Query: 390 GAEENVVCESPVEIIKSKEVESALQTVDLNEGDAAPEPTEAKLKREESKPRTSL------ 443
A + P K+ E S D +E D AP K +KP +
Sbjct: 342 KAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVK 401
Query: 444 -MAFLRQMSVKGDGGITHSEEING--KDSSCQTSDSTEKTITPPEPEPTG---------- 490
A +Q G +T + + ++SS + T+K + +P+ T
Sbjct: 402 PAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQ 461
Query: 491 APQKGKEGSSKDKKSAAEMNKQKSNKQEAK-------------EPAQCTEQATVDTNSLQ 537
APQ ++ SS S++E ++K++K K +PA + +NS
Sbjct: 462 APQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSS 521
Query: 538 NGDKLQKRPEK 548
+ D ++ EK
Sbjct: 522 SDDSSEEEEEK 532
Score = 48.1 bits (113), Expect = 2e-05
Identities = 112/554 (20%), Positives = 197/554 (35%), Gaps = 83/554 (14%)
Query: 60 ATSSPETTEISAVADANGKNLGKEAKPEAPAAKSRFFLMLSRPVPGRTGDQAADSSLGSV 119
++SS E+++ D + + K KP+A AAK + P ++ D +DSS
Sbjct: 126 SSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAK-------APPKKAKSSDSDSDSS---- 174
Query: 120 KLDVSSNKAPANKDPSESWTLPVAAGPGQDTDKTPGHAP---AQDKVLSAARDPTLLPPE 176
S ++ P N+ P PV P A A K S++ +
Sbjct: 175 ----SEDEPPKNQKPK---ITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSS 227
Query: 177 TGGAGGEAPSKPKDSSFFDKFFKLDKGQEKV------PGDSQQEAKRAEHQDKVDEVPGL 230
+A + PK + K + K K S +++ E +++ +
Sbjct: 228 DDSEEEKAAATPKKT--VPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNK 285
Query: 231 SGQSDDVPAGKDIVDGKEKEGQELGTADCSVPGDPEGLETAKDDSQAAAIAENNNSIMSF 290
G VP K+ G + E E + D+S +++ E
Sbjct: 286 PGPYSSVPP-PSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPT--- 341
Query: 291 FKTLVSPNKAETKKDPEDTGAEKSPTTSADLKSDKANFTSQETQGAGKNSKGCNPSGHTQ 350
K +VS KA TK P AE S + S+D S + + + G KN S +
Sbjct: 342 -KAVVS--KATTKPPPAKKAAESS-SDSSDSDSSEDDEAPSKPAGTTKN------SSNKP 391
Query: 351 SVTTPEPAKEGTKEKSGPTSLPLGKLFWKKSVKEDSVPTGAEENVVCESPVEIIKSKEVE 410
+VTT PA + P L K + + E + V K K
Sbjct: 392 AVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATA 451
Query: 411 SALQTVDLNEG-----DAAPEPTEAKLKREESKPRTSLMAFLRQMSVKGDGGITHSEEIN 465
A ++ + D++ + + + EE K S +++ K GG S+ +
Sbjct: 452 KAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSA---VKKKPQKVAGGAAPSKPAS 508
Query: 466 GKDSSCQTSDSTEKTITPPEPEP----TGAP---------------QKGK------EGSS 500
K ++S+S+ + E E G+P Q GK E
Sbjct: 509 AKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEE 568
Query: 501 KDKKSAAEMNKQKS-NKQEAKEPAQCTEQATVDTNSLQNGDKLQKRPEKRQQSLGGFFKG 559
+ KK+A ++K S K++ E A+ E LQ + KR + +++ F
Sbjct: 569 EKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNTFPKRKKGEKRASSPF--- 625
Query: 560 LGPKRMLDAQVQTD 573
+R+ + +++ D
Sbjct: 626 ---RRVREEEIEVD 636
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 54.7 bits (130), Expect = 2e-07
Identities = 90/571 (15%), Positives = 201/571 (35%), Gaps = 42/571 (7%)
Query: 8 PQRVEDQENEPEAETYQDNASALNGVPVVVSTHTVQHLEEVDLGISVKTDNVATSSPETT 67
P+ ED NE + + + G+P + ++ ++++ S + +N T ET
Sbjct: 307 PEGKEDPHNEVDGDKTSKSEENSAGIPEDNGSQRIEDTQKLNHRESKRVENRITKESETH 366
Query: 68 EISAVAD---------ANGKNLGKEAKP--EAPAAKSRFFLMLSRPVPGRTGDQA----- 111
+ D + +N+ KE E K + ++L + G+
Sbjct: 367 AVGKSQDKGIEIKGPSSGNRNITKEVGKGNEGKEDKGQHGMILGKGNVKTQGEVVNIEGP 426
Query: 112 ADSSLGSVKLDVSSNKAPANKDPSESWTLPVAAGPGQD---TDKTPGHAPA---QDKVLS 165
S K+ S+ + +N D +S+ + G D +D++ G+ A D S
Sbjct: 427 GQKSEPGNKVGHSNTGSDSNSDGYDSYDFDDKSMQGDDPNSSDESNGNDDANSESDNNSS 486
Query: 166 AARDPTLLPPETGGAGGEAPSKPKDSSFFDKFFKLDKGQEKVPGDSQQEAKRAEHQDKVD 225
+ D + E+ G + SK + D + G++ + DK D
Sbjct: 487 SRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGN-----DDNDKSD 541
Query: 226 EVPGLSGQSD----DVPAGKDIVDGKEKEGQELGTADCSVPGDPEGLETAKDDSQAAAIA 281
G S SD D D D + + + ++ S D + +++ DS ++
Sbjct: 542 SGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSS-- 599
Query: 282 ENNNSIMSFFKTLVSPNKAETKKDPEDTGAEKSPTTSADLKSDKANFTSQETQGAGKNSK 341
N++ + S + +++ D+ +S ++ +D KSD ++ S ++ +S
Sbjct: 600 -NSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSD 658
Query: 342 GCNPSGHTQSVTTPEPAKEGTKEKSGPTSLPLGKLFWKKSVKEDSVPTGAEENVVCESPV 401
N S + S + + + + S +S S + ++ + S
Sbjct: 659 SSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDS 718
Query: 402 EIIKSKEVESALQTVDLNEGDAAPEPTEAKLKREESKPRTSLMAFLRQMSVKGDGGITHS 461
S + +S+ N D++ + +S + S D + S
Sbjct: 719 SNSNSSDSDSS------NSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDS--SDS 770
Query: 462 EEINGKDSSCQTSDSTEKTITPPEPEPTGAPQKGKEGSSKDKKSAAEMNKQKSNKQEAKE 521
+ + S +SDS + + + + + + S D +++ + S+
Sbjct: 771 SDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSS 830
Query: 522 PAQCTEQATVDTNSLQNGDKLQKRPEKRQQS 552
+ + ++ ++S + D R S
Sbjct: 831 DSSDSSNSSDSSDSSDSSDGSDSDSSNRSDS 861
Score = 47.8 bits (112), Expect = 3e-05
Identities = 65/436 (14%), Positives = 154/436 (35%), Gaps = 17/436 (3%)
Query: 109 DQAADSSLGSVKLDVSSNKAPANKDPSESWTLPVAAGPGQ-DTDKTPGHAPAQDKVLSAA 167
D +DS+ + D + N N D +S +G G+ D+ + + S +
Sbjct: 512 DDDSDSTSDTNNSDSNGNGNNGNDDNDKS-----DSGKGKSDSSDSDSSDSSNSSDSSDS 566
Query: 168 RDPTLLPPETGGAGGEAPSKPKDSSFFDKFFKLDKGQEKVPGDSQQEAKRAEHQDKVDEV 227
D + + S DSS D + DS + ++ D +
Sbjct: 567 SDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDS 626
Query: 228 PGLSGQSDDVPAGKDIVDGKEKEGQELG-TADCSVPGDPEGLETAKDDSQAAAIAENNNS 286
S D + D D + + ++D S + + D S +++ ++++NS
Sbjct: 627 SKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNS 686
Query: 287 IMSFFKTLVSPNKAETK--KDPEDTGAEKSPTTSADLKSDKANFTSQETQGAGKNSKGCN 344
S + S N +E+ D D+ + S +S SD + S ++ + +S +
Sbjct: 687 SDSSDSS-DSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSD 745
Query: 345 PSGHTQSVTTPEPAKEGTKEKSGPTSLPLGKLFWKKSVKEDSVPTGAEENVVCESPVEII 404
S + S + + + S +S + S + + ++ +
Sbjct: 746 SSDSSNSSDSSDSSDSSNSSDSSDSSD-------SSDSSDSSNSSDSNDSSNSSDSSDSS 798
Query: 405 KSKEVESALQTVDLNEGDAAPEPTEAKLKREESKPRTSLMAFLRQMSVKGDGGITHSEEI 464
S + ++ + D ++ + + +S + S DG + S
Sbjct: 799 NSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNR 858
Query: 465 NGKDSSCQTSDSTEKTITPPEPEPTGAPQKGKEGSSKDKKSAAEMNKQKSNKQEAKEPAQ 524
+ +S +SDS++ + + + + + + S D ++++ + S+ +
Sbjct: 859 SDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSS 918
Query: 525 CTEQATVDTNSLQNGD 540
+ ++ +NS N +
Sbjct: 919 NSSDSSESSNSSDNSN 934
Score = 39.3 bits (90), Expect = 0.010
Identities = 65/484 (13%), Positives = 167/484 (34%), Gaps = 26/484 (5%)
Query: 60 ATSSPETTEISAVADANGKNLGKEAKPEAPAAKSRFFLMLSRPVPGRTGDQAADSSLGSV 119
++ S +++ S +D++ + ++ + ++ S S + DSS S
Sbjct: 734 SSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSD 793
Query: 120 KLDVSSNKAPANKDPSESWTLPVAAGPGQDTDKTPGHAPAQDKVLSAARDPTLLPPETGG 179
D SSN + ++ S + + ++ + + + D S + D + + G
Sbjct: 794 SSD-SSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDS--SNSSDSSDSSDSSDG 850
Query: 180 AGGEAPSKPKDSSFFDKFFKLDKGQEKVPGDSQQEAKRAEHQDKVDEVPGLSGQSDDVPA 239
+ ++ ++ S+ D D DS + + D D S D
Sbjct: 851 SDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSN 910
Query: 240 GKDIVDGKEKE--------GQELGTADCSVPGDPEGLETAKDDSQAAAIAENNNSIMSFF 291
D D ++D S D + + S ++ ++++NS S
Sbjct: 911 SSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSD 970
Query: 292 KTLVSPNKAETKKDPEDTGAEKSPTTSADLKSDKANFTSQETQGAGKNSKGCNPSGHTQS 351
+ + D D+ + S+D + + S ++ + +S N S + S
Sbjct: 971 SNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNS 1030
Query: 352 VTTPEPAKEGTKEKSGPTSLPLGKLFWKKSVKEDSVPTGAEENVVCESPVEIIKSKEVES 411
+ + + S +S + S + + ++ + S +
Sbjct: 1031 SDSSDSSDSSDSSDSSDSS----------DSSDSSNSSDSSDSSDSSDSSDSSDSSDSSD 1080
Query: 412 ALQTVDLNEGDAAPEPTEAKLKREESKPRTSLMAFLRQMSVKGDGGITHSEEINGKDSSC 471
+ ++ D ++ + + +++ + S S + S S+ + DSS
Sbjct: 1081 SSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSS- 1139
Query: 472 QTSDSTEKTITPPEPEPTGAPQKGKEGSSKDKKSAAEMNKQKSNKQEAKEPAQCTEQATV 531
+SDS++ + + + + + S D +++ SN ++ + + ++ +
Sbjct: 1140 NSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSD----SSNSSDSSDSSDSSDSSDS 1195
Query: 532 DTNS 535
+S
Sbjct: 1196 SDSS 1199
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 53.9 bits (128), Expect = 4e-07
Identities = 115/550 (20%), Positives = 203/550 (36%), Gaps = 81/550 (14%)
Query: 55 KTDNVATSS--------PETTEISAVADANGKNLGKEAKPEAPAAKSRFFLMLSRPVPGR 106
KT N TS+ E IS + G+ G E + AA
Sbjct: 1775 KTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAG------------- 1821
Query: 107 TGDQAADSSLGSVKLDVSSNKAPANKDPSESWTLPVAAGPGQDTD-------------KT 153
GDQ S G+ ++ + A + SE P A G Q+ + +
Sbjct: 1822 -GDQDPGQSDGAEGIEAPEAEGEAQPE-SEGVEAPEAEGDAQEAEGEAQPESEDVEAPEA 1879
Query: 154 PGHAPAQDKVLSAARDPTLLPPETGGAGGEAPSKPKDSSFFDKFFKLDKGQEKVPGDSQQ 213
G A + + + + PE+ GA EAP K++ + + + + G+ +
Sbjct: 1880 EGEAQPESEDVETPEAEWEVQPESEGA--EAPEAEKEAQPETESVEALETE----GEDEP 1933
Query: 214 EAKRAEHQDKVDEVPGLSGQSDDVPAGKDIVDGKEKEGQELGTADCSVPGDPEGLETAKD 273
E++ AE Q+ + GQ+ ++++ +E E + ++ D E LE +
Sbjct: 1934 ESEGAEAQEAEEAAQEAEGQTQPE---SEVIESQEAEEEAQPESE-----DVEALEVEVE 1985
Query: 274 DSQAAAIAENNNSIMSFFKTLVSPNKAETKKDPEDTGAEKSPTTSADLKSDKANFTSQET 333
+A A+ + + + +AE + PE G E P + + +QE
Sbjct: 1986 TQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGE--------EAQEV 2037
Query: 334 QGAGKNSKGCNPSGHTQSVTTPEPAKEGTKEKSGPTSLPLGKLFWKKSVKEDSVPTGAEE 393
+G + ++G + + V PE A+E +E G G+ ED AE
Sbjct: 2038 EGETQKTEG-DAQPESDGVEAPE-AEEEAQEAEGEVQEAEGE---AHPESEDVDAQEAEG 2092
Query: 394 NVVCESPVEIIKSKEVESALQTVD-----LNEGDAAPEP--TEAKLKREESKPRTSLMAF 446
ES E +++ E E Q + EG+A PE EA E++P +
Sbjct: 2093 EAQPES--EGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESE---G 2147
Query: 447 LRQMSVKGDGGITHSEEINGKDSSCQTSDSTEKTITPPEPEPTGAPQKGKEG-SSKDKKS 505
+ +G+ SE I +++ + E PE G Q EG + + +
Sbjct: 2148 VEAQDAEGEAQ-PESEGIEAQEAEEEAQPELEGV---EAPEAEGEAQPESEGIEAPEAEG 2203
Query: 506 AAEMNKQKSNKQEAKEPAQCTEQATVDTNSLQNGDKLQKRPEKRQQSLGGFFKGLGPKRM 565
A+ + EA+E AQ E V+T + + + E + + G LG +
Sbjct: 2204 EAQPELEGVEAPEAEEEAQ-PEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQS 2262
Query: 566 LDAQVQTDPV 575
+A + PV
Sbjct: 2263 EEASESSSPV 2272
Score = 39.3 bits (90), Expect = 0.010
Identities = 87/462 (18%), Positives = 162/462 (35%), Gaps = 120/462 (25%)
Query: 62 SSPETTEISAVADANGKNLGKEAKPEAPAAKSRFFLMLSRPVPGRTGD------------ 109
+ PET + A+ E +PE+ A+++ ++ G+T
Sbjct: 1915 AQPETESVEALETEG------EDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEE 1968
Query: 110 --QAADSSLGSVKLDVSSNKAPANKDP-SESWTLPVAAGPGQDTDKTPGHAPAQDKVLSA 166
Q + +++++V + +A P SE P A G Q+ ++
Sbjct: 1969 EAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEA------------ 2016
Query: 167 ARDPTLLPPETGGAGGEAPSKPKDSSFFDKFFKLDKGQEKVPGDSQQEAKRAEHQDKVDE 226
PE+ G + S+ +++ +++ +K GD+Q E+ E + +E
Sbjct: 2017 -------QPESDGVEAQPKSEGEEAQ------EVEGETQKTEGDAQPESDGVEAPEAEEE 2063
Query: 227 VPGLSGQSDDV-----PAGKDIVDGKEKEGQELGTADCSVPGDPEGLETAKDDSQAAAIA 281
G+ + P +D VD +E EG+ + EG+E + + +A A
Sbjct: 2064 AQEAEGEVQEAEGEAHPESED-VDAQEAEGE--------AQPESEGVEAPEAEGEAQK-A 2113
Query: 282 ENNNSIMSFFKTLVSPNKAETKKDPEDTGAEKSPTTSADLKSDKANFTSQETQG-AGKNS 340
E + + E + PE G E +P + + + +Q+ +G A S
Sbjct: 2114 EG-----------IEAPETEGEAQPESEGIE-APEAEGEAQPESEGVEAQDAEGEAQPES 2161
Query: 341 KGCNPSG-------HTQSVTTPEPAKEGTKEKSGPTSLPLGKLFWKKSVKEDSVPTGAEE 393
+G + V PE E E G P + + ++ P EE
Sbjct: 2162 EGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEG-IEAPEAEGEAQPELEGVEAPEAEEE 2220
Query: 394 NVVCESPVEIIKSKEVESALQTVDLNEGDAAPEPTEAKLKREESKPRTSLMAFLRQMSVK 453
+ E +++ E E G+A PE ++ P+ SL
Sbjct: 2221 ---AQPEPEGVETPEAE----------GEAQPESEGETQGEKKGSPQVSL---------- 2257
Query: 454 GDGGITHSEEINGKDSSCQTSDSTEKTITPPEPEPTGAPQKG 495
GDG Q+ +++E + PE PT P G
Sbjct: 2258 GDG---------------QSEEASESSSPVPEDRPTPPPSPG 2284
Score = 30.4 bits (67), Expect = 4.7
Identities = 87/407 (21%), Positives = 143/407 (35%), Gaps = 82/407 (20%)
Query: 202 KGQEKVPGDSQQ--EAKRAEHQDKVDEVPGLSGQSDDVPAGK---DIVDGKEKEGQE--L 254
+G K D QQ + KR EH D G++ +V GK D + +G E L
Sbjct: 1680 RGPIKEAFDLQQILQRKRGEHTD---------GEAAEVAPGKTHTDPTSTRTVQGAEGGL 1730
Query: 255 GTADCSVPGDPEG--------LETAKD----DSQAAAIAENNNSIMSFFKTLVSPNKAET 302
G PG EG L KD +++ A+A+ +T E
Sbjct: 1731 GPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEA 1790
Query: 303 KKDPEDTGAEKSPTTSADLKSDKANFTSQETQGAGKN---SKGCNPSGHTQSVTTPEPAK 359
+++ E G + T + N + G ++ S G ++ +P
Sbjct: 1791 EQEGE--GISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPES 1848
Query: 360 EGTK--EKSGPTSLPLGKLFWKKSVKEDSVPTGAEENVVCESPVEIIKSKEVESALQTVD 417
EG + E G G+ + ED AE ES E +++ E E +Q
Sbjct: 1849 EGVEAPEAEGDAQEAEGEA---QPESEDVEAPEAEGEAQPES--EDVETPEAEWEVQPE- 1902
Query: 418 LNEGDAAPEPTEAKLKREESKPRTSLMAFLRQMSVKGDGGITHSEEINGKDSSCQTSDST 477
+EG APE +E++P T + L E G+D
Sbjct: 1903 -SEGAEAPEA------EKEAQPETESVEAL---------------ETEGED--------- 1931
Query: 478 EKTITPPEPEPTGAPQKGKEGSSKDKKSAAEMNKQKSNKQEAKEPAQCTEQATVDTNSLQ 537
EPE GA + E ++++ + + + QEA+E AQ + D +L+
Sbjct: 1932 -------EPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESE---DVEALE 1981
Query: 538 NGDKLQKRPEKRQQSLGGFFKGLGPKRMLDAQVQTDPVSIGPVGKSK 584
+ Q+ + Q M +A+ + P S G + K
Sbjct: 1982 VEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPK 2028
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 51.6 bits (122), Expect = 2e-06
Identities = 108/540 (20%), Positives = 200/540 (37%), Gaps = 76/540 (14%)
Query: 50 LGISVKTDNVATSSPETTEISAVADANGKNLGKEAKPEAPAAKSRFFLMLSRPVPGRTGD 109
+ + VK + +S + E S AD+ A PA K + ++ P +T +
Sbjct: 595 VAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALK----IPQTKACPKKT-N 649
Query: 110 QAADSSLGSVKLDVSSNKAPANKDPSESWTLPVAAG----PGQDTDK------------- 152
A + + V++ + + A S + + P AG P +D+
Sbjct: 650 TTASAKVAPVRVGTQAPRK-AGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGL 708
Query: 153 --TPGHAPAQDKVLSAARDPTLLPPETGGAG-GEAPSKPKDSSFFDKFFKLDKGQEKVPG 209
T G A + K L P G G G AP P + K +K ++
Sbjct: 709 AVTVGQAKSVGKGLQVKAASV---PVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESS 765
Query: 210 DSQQEAKRAEHQDKVDEVPGLSGQSDDVPAGKDIVDGK---EKEGQELGTADCSVPGDPE 266
+ + +++ A + Q+ PA K G+ + A + P
Sbjct: 766 EEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPS 825
Query: 267 GLET-AKDDSQAAAIAENNNSIMSFFKTLVSPNKAETKKDPEDTGAEKSPTTSADLKSDK 325
++ ++ + +A S+ S K + + +A+T + ED+G+ + + S +
Sbjct: 826 KVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPE-EDSGSSEEESDSEE----- 879
Query: 326 ANFTSQETQGAGKNSKGCNPSGHTQSVTTP-EPAKEGTKE--------KSGPTSLPLGKL 376
ET K PSG T + PAKE ++ K+GP++ GK
Sbjct: 880 ----EAETLAQVK------PSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGK- 928
Query: 377 FWKKSVKEDSVPTGAEENVVCESPVEIIKSKEVESALQTVDLNEGDAAPEPTEAKLKREE 436
++DS + E + E+P + ++ ++ L VD N A P T A+ +
Sbjct: 929 ------QDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQ-AQAA 981
Query: 437 SKPRTSLMAFLRQMSVKGDGGITHSEEINGKDSSCQTSDSTEKTITPPEPEPTGAPQKGK 496
S PR A + + + + E++ + C T +T P P AP+
Sbjct: 982 STPR---KARASESTARSSSSESEDEDVI-PATQCLTPGIRTNVVTMPTAHPRIAPKASM 1037
Query: 497 EGSSKDKKSA--AEMNKQKSNKQEAKEPAQCTEQATVDTNSLQ----NGDKLQKRPEKRQ 550
G+S K+S+ ++ KQ+ + + + S+Q N + K PE +Q
Sbjct: 1038 AGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQ 1097
Score = 36.2 bits (82), Expect = 0.086
Identities = 107/488 (21%), Positives = 162/488 (33%), Gaps = 91/488 (18%)
Query: 58 NVATSSPETTEISAVADANGKNLGKEA-------KPEAPAAKSRFFL-MLSRPVPGRTGD 109
NV T I+ A G + KE+ K E PA + + L P T
Sbjct: 1020 NVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSV 1079
Query: 110 QAADSS-LGSVKLDV--SSNKAPANKDPSESWTLPVAAGPGQDTDKTPGHAPAQDKVLSA 166
QA ++ L KL + KAP + D SE + ++G +D + G A V
Sbjct: 1080 QAKGTNKLRKPKLPEVQQATKAPESSDDSED-SSDSSSGSEEDGEGPQGAKSAHTLVGPT 1138
Query: 167 ARDPTLLPPETGGAGGE----APSKPKDSSFFDKFFKLDKGQEKVPGDSQQEAKRAEHQD 222
L ET E APS+ S + PG + ++ ++
Sbjct: 1139 PSRTETLVEETAAESSEDDVVAPSQSLLSGYM------------TPGLTPANSQASKATP 1186
Query: 223 KVDEVPGLSGQSDDVPAGKDIVDGKE--KEGQELGTADCSVPGDPEGLETAKDDS----- 275
K+D P +S A KD DGK+ K Q G G T S
Sbjct: 1187 KLDSSPSVSSTL----AAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKK 1242
Query: 276 -----QAAAIAENNNSIMSFFKTLVSPNKAETKKDPEDTGAEKSPTTSADLKSDKANFTS 330
QA+ +A +N N+A+ + K T + + K T+
Sbjct: 1243 GAGNPQASTLALQSNITQCLLGQPWPLNEAQVQ-----ASVVKVLTELLEQERKKVVDTT 1297
Query: 331 QETQGAGKNSKGCNPSGHTQSVTTPEPAKEGTKEKSGPTSLPLGKLFWKKSVKEDSVPTG 390
+E+ G S+ SG + TP K K+K G G
Sbjct: 1298 KESSRKGWESRKRKLSGDQPAARTPRSKK---KKKLGAGE-------------------G 1335
Query: 391 AEENVVCESPVEIIKSKEVESALQTVDLNEGDAAPEPTEAKLKREESK--PRTSLMAFLR 448
E +V E K K D GD + + L + +K P L
Sbjct: 1336 GEASVSPEKTSTTSKGKAKR------DKASGDVKEKKGKGSLGSQGAKDEPEEELQ---- 1385
Query: 449 QMSVKGDGGITHSEEINGKDSSCQTSDSTEKTITPPEPEPTGAPQKGKEGSSKDKKSAAE 508
KG G + ++ N K + K + E +K K+ S+KD +S ++
Sbjct: 1386 ----KGMGTVEGGDQSNPKSKKEKKKSDKRKK----DKEKKEKKKKAKKASTKDSESPSQ 1437
Query: 509 MNKQKSNK 516
K+K K
Sbjct: 1438 KKKKKKKK 1445
Score = 33.5 bits (75), Expect = 0.56
Identities = 69/338 (20%), Positives = 115/338 (34%), Gaps = 50/338 (14%)
Query: 50 LGISVKTDNVATSSPETTEISAVADANGKNLGKEAKPEAPAAKSRFFLMLSRPV------ 103
+G +V T A + PE S+ +++ + + P+ K+ P
Sbjct: 850 VGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRK 909
Query: 104 ------PGRTGDQAA-----DSSLGSVKLDVSSNKAPANKDPSESWTLPVAAGPGQDTDK 152
PG+TG AA D S S + S +APA ++ P+ +
Sbjct: 910 GAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPA 969
Query: 153 TPGHAPAQDKVLSAARDPTLLPPETGGAGGEAPSKPKDSSFFDKFFKLDKGQEKVPGDSQ 212
P PAQ + S R E+ + S+ +D + Q PG
Sbjct: 970 GPAATPAQAQAASTPRKARA--SESTARSSSSESEDEDV--------IPATQCLTPGIRT 1019
Query: 213 QEAKRAEHQDKVDEVPGLSGQSDDVPAGKDIVDGKEKEGQELGTADCSVPGDPEGLETAK 272
++ ++G S + + I DGK++EG D +V P
Sbjct: 1020 NVVTMPTAHPRIAPKASMAGASSSKESSR-ISDGKKQEGPAT-QVDSAVGTLP------- 1070
Query: 273 DDSQAAAIAENNNSIMSFFKTLVSPNKAETKKDPEDTGAEKSPTTSADLKSDKANFTSQE 332
A + + S+ + NK K PE A K+P +S D + + + E
Sbjct: 1071 ------ATSPQSTSVQA-----KGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSE 1119
Query: 333 TQGAGKNSKGCNPSGHTQSVTTPEPAKEGTKEKSGPTS 370
G G S HT TP + +E + +S
Sbjct: 1120 EDGEGPQGA---KSAHTLVGPTPSRTETLVEETAAESS 1154
Score = 30.8 bits (68), Expect = 3.6
Identities = 60/288 (20%), Positives = 107/288 (37%), Gaps = 53/288 (18%)
Query: 299 KAETKKDPEDTGAEKSPTTSADLKSD-KANFTSQETQGAGKNSKGCNPSGHTQSVTTPEP 357
K E + + + G+E A +S KA+ + + A +KG G T + P
Sbjct: 265 KPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPA----PP 320
Query: 358 AKEGTKEKSGPTSLPLGKLFWKKSVKEDSVPTGAEENVVCESPVEIIKSKEVESALQTVD 417
K G P +EDS + E + +S E +K + A +
Sbjct: 321 GKAGAVASQTKAGKP----------EEDSESSSEESS---DSEEETPAAKALLQAKASGK 367
Query: 418 LNEGDAAPEPTEAKLKR--EESKPRTSLMAFLRQMSVKGDGGITHSEEINGKDSSCQTSD 475
++ AA P + ++ + P + A + + K + SS + SD
Sbjct: 368 TSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKRE---------EDSQSSSEESD 418
Query: 476 STEKTITPPEPEPTG--------------APQKGKEGSSKDKKSAA----EMNKQKSNKQ 517
S E+ P + +P+G +P+KG + K A ++ KQ+ + +
Sbjct: 419 SEEEA--PAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSR 476
Query: 518 EAKEPAQCTEQATVDTNSLQNGDKLQKRPEKRQQS---LGGFFKGLGP 562
+ E + +A N+ Q L K P+ + S +G KG GP
Sbjct: 477 SSSEESDSDREALAAMNAAQ-VKPLGKSPQVKPASTMGMGPLGKGAGP 523
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a [Homo
sapiens]
Length = 1450
Score = 51.6 bits (122), Expect = 2e-06
Identities = 108/540 (20%), Positives = 200/540 (37%), Gaps = 76/540 (14%)
Query: 50 LGISVKTDNVATSSPETTEISAVADANGKNLGKEAKPEAPAAKSRFFLMLSRPVPGRTGD 109
+ + VK + +S + E S AD+ A PA K + ++ P +T +
Sbjct: 595 VAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALK----IPQTKACPKKT-N 649
Query: 110 QAADSSLGSVKLDVSSNKAPANKDPSESWTLPVAAG----PGQDTDK------------- 152
A + + V++ + + A S + + P AG P +D+
Sbjct: 650 TTASAKVAPVRVGTQAPRK-AGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGL 708
Query: 153 --TPGHAPAQDKVLSAARDPTLLPPETGGAG-GEAPSKPKDSSFFDKFFKLDKGQEKVPG 209
T G A + K L P G G G AP P + K +K ++
Sbjct: 709 AVTVGQAKSVGKGLQVKAASV---PVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESS 765
Query: 210 DSQQEAKRAEHQDKVDEVPGLSGQSDDVPAGKDIVDGK---EKEGQELGTADCSVPGDPE 266
+ + +++ A + Q+ PA K G+ + A + P
Sbjct: 766 EEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPS 825
Query: 267 GLET-AKDDSQAAAIAENNNSIMSFFKTLVSPNKAETKKDPEDTGAEKSPTTSADLKSDK 325
++ ++ + +A S+ S K + + +A+T + ED+G+ + + S +
Sbjct: 826 KVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPE-EDSGSSEEESDSEE----- 879
Query: 326 ANFTSQETQGAGKNSKGCNPSGHTQSVTTP-EPAKEGTKE--------KSGPTSLPLGKL 376
ET K PSG T + PAKE ++ K+GP++ GK
Sbjct: 880 ----EAETLAQVK------PSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGK- 928
Query: 377 FWKKSVKEDSVPTGAEENVVCESPVEIIKSKEVESALQTVDLNEGDAAPEPTEAKLKREE 436
++DS + E + E+P + ++ ++ L VD N A P T A+ +
Sbjct: 929 ------QDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQ-AQAA 981
Query: 437 SKPRTSLMAFLRQMSVKGDGGITHSEEINGKDSSCQTSDSTEKTITPPEPEPTGAPQKGK 496
S PR A + + + + E++ + C T +T P P AP+
Sbjct: 982 STPR---KARASESTARSSSSESEDEDVI-PATQCLTPGIRTNVVTMPTAHPRIAPKASM 1037
Query: 497 EGSSKDKKSA--AEMNKQKSNKQEAKEPAQCTEQATVDTNSLQ----NGDKLQKRPEKRQ 550
G+S K+S+ ++ KQ+ + + + S+Q N + K PE +Q
Sbjct: 1038 AGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQ 1097
Score = 37.0 bits (84), Expect = 0.050
Identities = 108/488 (22%), Positives = 166/488 (34%), Gaps = 92/488 (18%)
Query: 58 NVATSSPETTEISAVADANGKNLGKEA-------KPEAPAAKSRFFL-MLSRPVPGRTGD 109
NV T I+ A G + KE+ K E PA + + L P T
Sbjct: 1020 NVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSV 1079
Query: 110 QAADSS-LGSVKLDV--SSNKAPANKDPSESWTLPVAAGPGQDTDKTPGHAPAQDKVLSA 166
QA ++ L KL + KAP + D SE + ++G +D + G A +
Sbjct: 1080 QAKGTNKLRKPKLPEVQQATKAPESSDDSED-SSDSSSGSEEDGEGPQGAKSAHTLGPTP 1138
Query: 167 ARDPTLLPPETGGAGGE----APSKPKDSSFFDKFFKLDKGQEKVPGDSQQEAKRAEHQD 222
+R TL+ ET E APS+ S + PG + ++ ++
Sbjct: 1139 SRTETLVE-ETAAESSEDDVVAPSQSLLSGYM------------TPGLTPANSQASKATP 1185
Query: 223 KVDEVPGLSGQSDDVPAGKDIVDGKE--KEGQELGTADCSVPGDPEGLETAKDDS----- 275
K+D P +S A KD DGK+ K Q G G T S
Sbjct: 1186 KLDSSPSVSSTL----AAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKK 1241
Query: 276 -----QAAAIAENNNSIMSFFKTLVSPNKAETKKDPEDTGAEKSPTTSADLKSDKANFTS 330
QA+ +A +N N+A+ + K T + + K T+
Sbjct: 1242 GAGNPQASTLALQSNITQCLLGQPWPLNEAQVQ-----ASVVKVLTELLEQERKKVVDTT 1296
Query: 331 QETQGAGKNSKGCNPSGHTQSVTTPEPAKEGTKEKSGPTSLPLGKLFWKKSVKEDSVPTG 390
+E+ G S+ SG + TP K K+K G G
Sbjct: 1297 KESSRKGWESRKRKLSGDQPAARTPRSKK---KKKLGAGE-------------------G 1334
Query: 391 AEENVVCESPVEIIKSKEVESALQTVDLNEGDAAPEPTEAKLKREESK--PRTSLMAFLR 448
E +V E K K D GD + + L + +K P L
Sbjct: 1335 GEASVSPEKTSTTSKGKAKR------DKASGDVKEKKGKGSLGSQGAKDEPEEELQ---- 1384
Query: 449 QMSVKGDGGITHSEEINGKDSSCQTSDSTEKTITPPEPEPTGAPQKGKEGSSKDKKSAAE 508
KG G + ++ N K + K + E +K K+ S+KD +S ++
Sbjct: 1385 ----KGMGTVEGGDQSNPKSKKEKKKSDKRKK----DKEKKEKKKKAKKASTKDSESPSQ 1436
Query: 509 MNKQKSNK 516
K+K K
Sbjct: 1437 KKKKKKKK 1444
Score = 35.0 bits (79), Expect = 0.19
Identities = 90/433 (20%), Positives = 150/433 (34%), Gaps = 67/433 (15%)
Query: 50 LGISVKTDNVATSSPETTEISAVADANGKNLGKEAKPEAPAAKSRFFLMLSRPV------ 103
+G +V T A + PE S+ +++ + + P+ K+ P
Sbjct: 850 VGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRK 909
Query: 104 ------PGRTGDQAA-----DSSLGSVKLDVSSNKAPANKDPSESWTLPVAAGPGQDTDK 152
PG+TG AA D S S + S +APA ++ P+ +
Sbjct: 910 GAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPA 969
Query: 153 TPGHAPAQDKVLSAARDPTLLPPETGGAGGEAPSKPKDSSFFDKFFKLDKGQEKVPGDSQ 212
P PAQ + S R E+ + S+ +D + Q PG
Sbjct: 970 GPAATPAQAQAASTPRKARA--SESTARSSSSESEDEDV--------IPATQCLTPGIRT 1019
Query: 213 QEAKRAEHQDKVDEVPGLSGQSDDVPAGKDIVDGKEKEGQELGTADCSVPGDPEGLETAK 272
++ ++G S + + I DGK++EG D +V P
Sbjct: 1020 NVVTMPTAHPRIAPKASMAGASSSKESSR-ISDGKKQEGPAT-QVDSAVGTLP------- 1070
Query: 273 DDSQAAAIAENNNSIMSFFKTLVSPNKAETKKDPEDTGAEKSPTTSADLKSDKANFTSQE 332
A + + S+ + NK K PE A K+P +S D + + + E
Sbjct: 1071 ------ATSPQSTSVQA-----KGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSE 1119
Query: 333 TQGAG-KNSKGCNPSGHTQSVT---TPEPAKEGTKEK---------SG---PTSLPLGKL 376
G G + +K + G T S T E A E +++ SG P P
Sbjct: 1120 EDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQ 1179
Query: 377 FWKKSVKEDSVPTGAEENVVCESPVEIIKSKEVESALQTVDLNEGDAAPEPTEAKLKREE 436
K + K DS P+ + + P ++K ++A G A T + R+
Sbjct: 1180 ASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKP 1239
Query: 437 SK----PRTSLMA 445
K P+ S +A
Sbjct: 1240 KKGAGNPQASTLA 1252
Score = 30.8 bits (68), Expect = 3.6
Identities = 60/288 (20%), Positives = 107/288 (37%), Gaps = 53/288 (18%)
Query: 299 KAETKKDPEDTGAEKSPTTSADLKSD-KANFTSQETQGAGKNSKGCNPSGHTQSVTTPEP 357
K E + + + G+E A +S KA+ + + A +KG G T + P
Sbjct: 265 KPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPA----PP 320
Query: 358 AKEGTKEKSGPTSLPLGKLFWKKSVKEDSVPTGAEENVVCESPVEIIKSKEVESALQTVD 417
K G P +EDS + E + +S E +K + A +
Sbjct: 321 GKAGAVASQTKAGKP----------EEDSESSSEESS---DSEEETPAAKALLQAKASGK 367
Query: 418 LNEGDAAPEPTEAKLKR--EESKPRTSLMAFLRQMSVKGDGGITHSEEINGKDSSCQTSD 475
++ AA P + ++ + P + A + + K + SS + SD
Sbjct: 368 TSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKRE---------EDSQSSSEESD 418
Query: 476 STEKTITPPEPEPTG--------------APQKGKEGSSKDKKSAA----EMNKQKSNKQ 517
S E+ P + +P+G +P+KG + K A ++ KQ+ + +
Sbjct: 419 SEEEA--PAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSR 476
Query: 518 EAKEPAQCTEQATVDTNSLQNGDKLQKRPEKRQQS---LGGFFKGLGP 562
+ E + +A N+ Q L K P+ + S +G KG GP
Sbjct: 477 SSSEESDSDREALAAMNAAQ-VKPLGKSPQVKPASTMGMGPLGKGAGP 523
>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
[Homo sapiens]
Length = 1412
Score = 51.2 bits (121), Expect = 3e-06
Identities = 99/490 (20%), Positives = 182/490 (37%), Gaps = 70/490 (14%)
Query: 50 LGISVKTDNVATSSPETTEISAVADANGKNLGKEAKPEAPAAKSRFFLMLSRPVPGRTGD 109
+ + VK + +S + E S AD+ A PA K + ++ P +T +
Sbjct: 518 VAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALK----IPQTKACPKKT-N 572
Query: 110 QAADSSLGSVKLDVSSNKAPANKDPSESWTLPVAAG----PGQDTDK------------- 152
A + + V++ + + A S + + P AG P +D+
Sbjct: 573 TTASAKVAPVRVGTQAPRK-AGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGL 631
Query: 153 --TPGHAPAQDKVLSAARDPTLLPPETGGAG-GEAPSKPKDSSFFDKFFKLDKGQEKVPG 209
T G A + K L P G G G AP P + K +K ++
Sbjct: 632 AVTVGQAKSVGKGLQVKAASV---PVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESS 688
Query: 210 DSQQEAKRAEHQDKVDEVPGLSGQSDDVPAGKDIVDGK---EKEGQELGTADCSVPGDPE 266
+ + +++ A + Q+ PA K G+ + A + P
Sbjct: 689 EEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPS 748
Query: 267 GLET-AKDDSQAAAIAENNNSIMSFFKTLVSPNKAETKKDPEDTGAEKSPTTSADLKSDK 325
++ ++ + +A S+ S K + + +A+T + ED+G+ + + S +
Sbjct: 749 KVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPE-EDSGSSEEESDSEE----- 802
Query: 326 ANFTSQETQGAGKNSKGCNPSGHTQSVTTP-EPAKEGTKE--------KSGPTSLPLGKL 376
ET K PSG T + PAKE ++ K+GP++ GK
Sbjct: 803 ----EAETLAQVK------PSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGK- 851
Query: 377 FWKKSVKEDSVPTGAEENVVCESPVEIIKSKEVESALQTVDLNEGDAAPEPTEAKLKREE 436
++DS + E + E+P + ++ ++ L VD N A P T A+ +
Sbjct: 852 ------QDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQ-AQAA 904
Query: 437 SKPRTSLMAFLRQMSVKGDGGITHSEEINGKDSSCQTSDSTEKTITPPEPEPTGAPQKGK 496
S PR A + + + + E++ + C T +T P P AP+
Sbjct: 905 STPR---KARASESTARSSSSESEDEDVI-PATQCLTPGIRTNVVTMPTAHPRIAPKASM 960
Query: 497 EGSSKDKKSA 506
G+S K+S+
Sbjct: 961 AGASSSKESS 970
Score = 43.5 bits (101), Expect = 5e-04
Identities = 109/515 (21%), Positives = 191/515 (37%), Gaps = 57/515 (11%)
Query: 56 TDNVATSSPETTEISAV--ADANGKNLGKEAKPEAPAAKSRFFLMLSRPVPGRTGDQAAD 113
++ + S ET A+ A A+GK + APA +S P PG+TG A
Sbjct: 266 SEESSDSEEETPAAKALLQAKASGKT-SQVGAASAPAKESPRKGAAPAP-PGKTGPAVAK 323
Query: 114 SSLGSVKLDVSSNKAPANKDPSESWTLPVAAGP-GQDTDKTPGHAPAQDKVLSAARDPTL 172
+ G + D S+ ++ + P A P G+ APA++ A
Sbjct: 324 AQAGKREEDSQSSSEESDSEEEA----PAQAKPSGKAPQVRAASAPAKESPRKGAAPAP- 378
Query: 173 LPPETGGAGGEAPSKPKDSSFFDKFFKLDKGQEKVPGDSQQEAKRAEHQDKVDEVPG--- 229
P +TG A + ++ + D +E + + + K +V
Sbjct: 379 -PRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGM 437
Query: 230 --LSGQSDDVPAGK------DIVDGKEKEGQELGTADCSVPGDPEGLETAKDDSQAAAIA 281
L + VP GK GK +E E + + S D E + TA +Q ++
Sbjct: 438 GPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGE-VPTAVAPAQEKSLG 496
Query: 282 ENNNSIMSFFKTLVSPNKA-------ETKKDPEDTGAEKSPTTSADLKSDKANFTSQETQ 334
+ + P KA + +K +++ + + + SAD + A T+ + +
Sbjct: 497 NILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAK 556
Query: 335 GAGK--NSKGCNPSGHTQSVTTPEPAKEGTK--EKSGPTSLPLGKLFWKKSVKEDSVPTG 390
A K +K C +T + P + GT+ K+G + P G +V G
Sbjct: 557 PALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGS--------SPAVAGG 608
Query: 391 AEENVVCESPVEIIKSKEVESAL-----QTVDLNEG---DAAPEPTEAKLKREESK--PR 440
+ S E S+E ++ L Q + +G AA P + L + + P
Sbjct: 609 TQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPG 668
Query: 441 TSLMAFLRQMSVKGDGGITHSEEINGKD---SSCQTSDSTEKTITPPEPEPTGAPQ-KGK 496
+ + + K + + EE + ++ S Q S +KT P AP KG
Sbjct: 669 KTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGT 728
Query: 497 EGSSKDKKSAAEMNKQKSNKQEAKEPAQCTEQATV 531
+ +AA KQ+S + K P + + +TV
Sbjct: 729 ISAPGKVVTAAAQAKQRS-PSKVKPPVRNPQNSTV 762
Score = 35.0 bits (79), Expect = 0.19
Identities = 74/357 (20%), Positives = 123/357 (34%), Gaps = 50/357 (14%)
Query: 50 LGISVKTDNVATSSPETTEISAVADANGKNLGKEAKPEAPAAKSRFFLMLSRPV------ 103
+G +V T A + PE S+ +++ + + P+ K+ P
Sbjct: 773 VGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRK 832
Query: 104 ------PGRTGDQAA-----DSSLGSVKLDVSSNKAPANKDPSESWTLPVAAGPGQDTDK 152
PG+TG AA D S S + S +APA ++ P+ +
Sbjct: 833 GAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPA 892
Query: 153 TPGHAPAQDKVLSAARDPTLLPPETGGAGGEAPSKPKDSSFFDKFFKLDKGQEKVPGDSQ 212
P PAQ + S R E+ + S+ +D + Q PG
Sbjct: 893 GPAATPAQAQAASTPRKARA--SESTARSSSSESEDEDV--------IPATQCLTPGIRT 942
Query: 213 QEAKRAEHQDKVDEVPGLSGQSDDVPAGKDIVDGKEKEGQELGTAD---CSVPGDPEGLE 269
++ ++G S + + I DGK++EG + S+P L+
Sbjct: 943 NVVTMPTAHPRIAPKASMAGASSSKESSR-ISDGKKQEGPATQVSKKNPASLPLTQAALK 1001
Query: 270 T----AKDDSQAAAIAENNNSIMSFFKTL--VSP----------NKAETKKDPEDTGAEK 313
A + A + ++ + S TL SP NK K PE A K
Sbjct: 1002 VLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATK 1061
Query: 314 SPTTSADLKSDKANFTSQETQGAGKNSKGCNPSGHTQSVTTPEPAKEGTKEKSGPTS 370
+P +S D + + + E G G S HT TP + +E + +S
Sbjct: 1062 APESSDDSEDSSDSSSGSEEDGEGPQGA---KSAHTLVGPTPSRTETLVEETAAESS 1115
Score = 34.7 bits (78), Expect = 0.25
Identities = 87/410 (21%), Positives = 135/410 (32%), Gaps = 80/410 (19%)
Query: 125 SNKAPANKDPSESWTLPVAAGPGQDTDKTPGHAPAQDKVLSAARDPTLLPPETGGAGGE- 183
+ KAP + D SE + ++G +D + G A V L ET E
Sbjct: 1059 ATKAPESSDDSED-SSDSSSGSEEDGEGPQGAKSAHTLVGPTPSRTETLVEETAAESSED 1117
Query: 184 ---APSKPKDSSFFDKFFKLDKGQEKVPGDSQQEAKRAEHQDKVDEVPGLSGQSDDVPAG 240
APS+ S + PG + ++ ++ K+D P +S A
Sbjct: 1118 DVVAPSQSLLSGYM------------TPGLTPANSQASKATPKLDSSPSVSSTL----AA 1161
Query: 241 KDIVDGKE--KEGQELGTADCSVPGDPEGLETAKDDS----------QAAAIAENNNSIM 288
KD DGK+ K Q G G T S QA+ +A +N
Sbjct: 1162 KDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQ 1221
Query: 289 SFFKTLVSPNKAETKKDPEDTGAEKSPTTSADLKSDKANFTSQETQGAGKNSKGCNPSGH 348
N+A+ + K T + + K T++E+ G S+ SG
Sbjct: 1222 CLLGQPWPLNEAQVQ-----ASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGD 1276
Query: 349 TQSVTTPEPAKEGTKEKSGPTSLPLGKLFWKKSVKEDSVPTGAEENVVCESPVEIIKSKE 408
+ TP K K+K G G E +V E K K
Sbjct: 1277 QPAARTPRSKK---KKKLGAGE-------------------GGEASVSPEKTSTTSKGKA 1314
Query: 409 VESALQTVDLNEGDAAPEPTEAKLKREESK--PRTSLMAFLRQMSVKGDGGITHSEEING 466
D GD + + L + +K P L KG G + ++ N
Sbjct: 1315 KR------DKASGDVKEKKGKGSLGSQGAKDEPEEELQ--------KGMGTVEGGDQSNP 1360
Query: 467 KDSSCQTSDSTEKTITPPEPEPTGAPQKGKEGSSKDKKSAAEMNKQKSNK 516
K + K + E +K K+ S+KD +S ++ K+K K
Sbjct: 1361 KSKKEKKKSDKRKK----DKEKKEKKKKAKKASTKDSESPSQKKKKKKKK 1406
Score = 32.3 bits (72), Expect = 1.2
Identities = 63/260 (24%), Positives = 93/260 (35%), Gaps = 25/260 (9%)
Query: 299 KAETKKDPEDTGAEKSPTTSADLKSDKANFTSQETQGAGK--NSKGCNPSGHTQSVTTPE 356
+AET K + S ADL S ET+ AGK NS +G T +
Sbjct: 95 EAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSG 154
Query: 357 PAKEGTKEKSGPTSLPLGKLFWKKSVKEDSVPT-GAEENVVCESPVEIIKSKEVESALQT 415
+ + E S T+L ++ +E SVP GA S + S E S+
Sbjct: 155 KSPRKSAEPSANTTLV------SETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSS--- 205
Query: 416 VDLNEGDAAPEPTEAKLK-REESKPRTSLMAFLRQMSVKGDGGITHSEEINGK------D 468
+E D + +E L+ R S P + G G S+ GK
Sbjct: 206 -SSDETDVEVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSES 264
Query: 469 SSCQTSDSTEKTITPPEPEPTGAPQKGKEGSSKDKKSAAEMNKQKSNKQEAKEPAQCTEQ 528
SS ++SDS E+T P Q G + +A+ K+ K A P T
Sbjct: 265 SSEESSDSEEET-----PAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGP 319
Query: 529 ATVDTNSLQNGDKLQKRPEK 548
A + + + Q E+
Sbjct: 320 AVAKAQAGKREEDSQSSSEE 339
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 51.2 bits (121), Expect = 3e-06
Identities = 99/490 (20%), Positives = 182/490 (37%), Gaps = 70/490 (14%)
Query: 50 LGISVKTDNVATSSPETTEISAVADANGKNLGKEAKPEAPAAKSRFFLMLSRPVPGRTGD 109
+ + VK + +S + E S AD+ A PA K + ++ P +T +
Sbjct: 595 VAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALK----IPQTKACPKKT-N 649
Query: 110 QAADSSLGSVKLDVSSNKAPANKDPSESWTLPVAAG----PGQDTDK------------- 152
A + + V++ + + A S + + P AG P +D+
Sbjct: 650 TTASAKVAPVRVGTQAPRK-AGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGL 708
Query: 153 --TPGHAPAQDKVLSAARDPTLLPPETGGAG-GEAPSKPKDSSFFDKFFKLDKGQEKVPG 209
T G A + K L P G G G AP P + K +K ++
Sbjct: 709 AVTVGQAKSVGKGLQVKAASV---PVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESS 765
Query: 210 DSQQEAKRAEHQDKVDEVPGLSGQSDDVPAGKDIVDGK---EKEGQELGTADCSVPGDPE 266
+ + +++ A + Q+ PA K G+ + A + P
Sbjct: 766 EEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPS 825
Query: 267 GLET-AKDDSQAAAIAENNNSIMSFFKTLVSPNKAETKKDPEDTGAEKSPTTSADLKSDK 325
++ ++ + +A S+ S K + + +A+T + ED+G+ + + S +
Sbjct: 826 KVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPE-EDSGSSEEESDSEE----- 879
Query: 326 ANFTSQETQGAGKNSKGCNPSGHTQSVTTP-EPAKEGTKE--------KSGPTSLPLGKL 376
ET K PSG T + PAKE ++ K+GP++ GK
Sbjct: 880 ----EAETLAQVK------PSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGK- 928
Query: 377 FWKKSVKEDSVPTGAEENVVCESPVEIIKSKEVESALQTVDLNEGDAAPEPTEAKLKREE 436
++DS + E + E+P + ++ ++ L VD N A P T A+ +
Sbjct: 929 ------QDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQ-AQAA 981
Query: 437 SKPRTSLMAFLRQMSVKGDGGITHSEEINGKDSSCQTSDSTEKTITPPEPEPTGAPQKGK 496
S PR A + + + + E++ + C T +T P P AP+
Sbjct: 982 STPR---KARASESTARSSSSESEDEDVI-PATQCLTPGIRTNVVTMPTAHPRIAPKASM 1037
Query: 497 EGSSKDKKSA 506
G+S K+S+
Sbjct: 1038 AGASSSKESS 1047
Score = 43.5 bits (101), Expect = 5e-04
Identities = 109/515 (21%), Positives = 191/515 (37%), Gaps = 57/515 (11%)
Query: 56 TDNVATSSPETTEISAV--ADANGKNLGKEAKPEAPAAKSRFFLMLSRPVPGRTGDQAAD 113
++ + S ET A+ A A+GK + APA +S P PG+TG A
Sbjct: 343 SEESSDSEEETPAAKALLQAKASGKT-SQVGAASAPAKESPRKGAAPAP-PGKTGPAVAK 400
Query: 114 SSLGSVKLDVSSNKAPANKDPSESWTLPVAAGP-GQDTDKTPGHAPAQDKVLSAARDPTL 172
+ G + D S+ ++ + P A P G+ APA++ A
Sbjct: 401 AQAGKREEDSQSSSEESDSEEEA----PAQAKPSGKAPQVRAASAPAKESPRKGAAPAP- 455
Query: 173 LPPETGGAGGEAPSKPKDSSFFDKFFKLDKGQEKVPGDSQQEAKRAEHQDKVDEVPG--- 229
P +TG A + ++ + D +E + + + K +V
Sbjct: 456 -PRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGM 514
Query: 230 --LSGQSDDVPAGK------DIVDGKEKEGQELGTADCSVPGDPEGLETAKDDSQAAAIA 281
L + VP GK GK +E E + + S D E + TA +Q ++
Sbjct: 515 GPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGE-VPTAVAPAQEKSLG 573
Query: 282 ENNNSIMSFFKTLVSPNKA-------ETKKDPEDTGAEKSPTTSADLKSDKANFTSQETQ 334
+ + P KA + +K +++ + + + SAD + A T+ + +
Sbjct: 574 NILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAK 633
Query: 335 GAGK--NSKGCNPSGHTQSVTTPEPAKEGTK--EKSGPTSLPLGKLFWKKSVKEDSVPTG 390
A K +K C +T + P + GT+ K+G + P G +V G
Sbjct: 634 PALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGS--------SPAVAGG 685
Query: 391 AEENVVCESPVEIIKSKEVESAL-----QTVDLNEG---DAAPEPTEAKLKREESK--PR 440
+ S E S+E ++ L Q + +G AA P + L + + P
Sbjct: 686 TQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPG 745
Query: 441 TSLMAFLRQMSVKGDGGITHSEEINGKD---SSCQTSDSTEKTITPPEPEPTGAPQ-KGK 496
+ + + K + + EE + ++ S Q S +KT P AP KG
Sbjct: 746 KTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGT 805
Query: 497 EGSSKDKKSAAEMNKQKSNKQEAKEPAQCTEQATV 531
+ +AA KQ+S + K P + + +TV
Sbjct: 806 ISAPGKVVTAAAQAKQRS-PSKVKPPVRNPQNSTV 839
Score = 36.6 bits (83), Expect = 0.066
Identities = 95/452 (21%), Positives = 158/452 (34%), Gaps = 67/452 (14%)
Query: 50 LGISVKTDNVATSSPETTEISAVADANGKNLGKEAKPEAPAAKSRFFLMLSRPV------ 103
+G +V T A + PE S+ +++ + + P+ K+ P
Sbjct: 850 VGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRK 909
Query: 104 ------PGRTGDQAA-----DSSLGSVKLDVSSNKAPANKDPSESWTLPVAAGPGQDTDK 152
PG+TG AA D S S + S +APA ++ P+ +
Sbjct: 910 GAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPA 969
Query: 153 TPGHAPAQDKVLSAARDPTLLPPETGGAGGEAPSKPKDSSFFDKFFKLDKGQEKVPGDSQ 212
P PAQ + S R E+ + S+ +D + Q PG
Sbjct: 970 GPAATPAQAQAASTPRKARA--SESTARSSSSESEDEDV--------IPATQCLTPGIRT 1019
Query: 213 QEAKRAEHQDKVDEVPGLSGQSDDVPAGKDIVDGKEKEGQELGTAD---CSVPGDPEGLE 269
++ ++G S + + I DGK++EG + S+P L+
Sbjct: 1020 NVVTMPTAHPRIAPKASMAGASSSKESSR-ISDGKKQEGPATQVSKKNPASLPLTQAALK 1078
Query: 270 T----AKDDSQAAAIAENNNSIMSFFKTL--VSP----------NKAETKKDPEDTGAEK 313
A + A + ++ + S TL SP NK K PE A K
Sbjct: 1079 VLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATK 1138
Query: 314 SPTTSADLKSDKANFTSQETQGAG-KNSKGCNPSGHTQSVT---TPEPAKEGTKEK---- 365
+P +S D + + + E G G + +K + G T S T E A E +++
Sbjct: 1139 APESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAP 1198
Query: 366 -----SG---PTSLPLGKLFWKKSVKEDSVPTGAEENVVCESPVEIIKSKEVESALQTVD 417
SG P P K + K DS P+ + + P ++K ++A
Sbjct: 1199 SQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSP 1258
Query: 418 LNEGDAAPEPTEAKLKREESK----PRTSLMA 445
G A T + R+ K P+ S +A
Sbjct: 1259 KTGGKEAASGTTPQKSRKPKKGAGNPQASTLA 1290
Score = 35.4 bits (80), Expect = 0.15
Identities = 88/410 (21%), Positives = 139/410 (33%), Gaps = 81/410 (19%)
Query: 125 SNKAPANKDPSESWTLPVAAGPGQDTDKTPGHAPAQDKVLSAARDPTLLPPETGGAGGE- 183
+ KAP + D SE + ++G +D + G A + +R TL+ ET E
Sbjct: 1136 ATKAPESSDDSED-SSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVE-ETAAESSED 1193
Query: 184 ---APSKPKDSSFFDKFFKLDKGQEKVPGDSQQEAKRAEHQDKVDEVPGLSGQSDDVPAG 240
APS+ S + PG + ++ ++ K+D P +S A
Sbjct: 1194 DVVAPSQSLLSGYM------------TPGLTPANSQASKATPKLDSSPSVSSTL----AA 1237
Query: 241 KDIVDGKE--KEGQELGTADCSVPGDPEGLETAKDDS----------QAAAIAENNNSIM 288
KD DGK+ K Q G G T S QA+ +A +N
Sbjct: 1238 KDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQ 1297
Query: 289 SFFKTLVSPNKAETKKDPEDTGAEKSPTTSADLKSDKANFTSQETQGAGKNSKGCNPSGH 348
N+A+ + K T + + K T++E+ G S+ SG
Sbjct: 1298 CLLGQPWPLNEAQVQ-----ASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGD 1352
Query: 349 TQSVTTPEPAKEGTKEKSGPTSLPLGKLFWKKSVKEDSVPTGAEENVVCESPVEIIKSKE 408
+ TP K K+K G G E +V E K K
Sbjct: 1353 QPAARTPRSKK---KKKLGAGE-------------------GGEASVSPEKTSTTSKGKA 1390
Query: 409 VESALQTVDLNEGDAAPEPTEAKLKREESK--PRTSLMAFLRQMSVKGDGGITHSEEING 466
D GD + + L + +K P L KG G + ++ N
Sbjct: 1391 KR------DKASGDVKEKKGKGSLGSQGAKDEPEEELQ--------KGMGTVEGGDQSNP 1436
Query: 467 KDSSCQTSDSTEKTITPPEPEPTGAPQKGKEGSSKDKKSAAEMNKQKSNK 516
K + K + E +K K+ S+KD +S ++ K+K K
Sbjct: 1437 KSKKEKKKSDKRKK----DKEKKEKKKKAKKASTKDSESPSQKKKKKKKK 1482
>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b
[Homo sapiens]
Length = 1411
Score = 51.2 bits (121), Expect = 3e-06
Identities = 99/490 (20%), Positives = 182/490 (37%), Gaps = 70/490 (14%)
Query: 50 LGISVKTDNVATSSPETTEISAVADANGKNLGKEAKPEAPAAKSRFFLMLSRPVPGRTGD 109
+ + VK + +S + E S AD+ A PA K + ++ P +T +
Sbjct: 518 VAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALK----IPQTKACPKKT-N 572
Query: 110 QAADSSLGSVKLDVSSNKAPANKDPSESWTLPVAAG----PGQDTDK------------- 152
A + + V++ + + A S + + P AG P +D+
Sbjct: 573 TTASAKVAPVRVGTQAPRK-AGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGL 631
Query: 153 --TPGHAPAQDKVLSAARDPTLLPPETGGAG-GEAPSKPKDSSFFDKFFKLDKGQEKVPG 209
T G A + K L P G G G AP P + K +K ++
Sbjct: 632 AVTVGQAKSVGKGLQVKAASV---PVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESS 688
Query: 210 DSQQEAKRAEHQDKVDEVPGLSGQSDDVPAGKDIVDGK---EKEGQELGTADCSVPGDPE 266
+ + +++ A + Q+ PA K G+ + A + P
Sbjct: 689 EEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPS 748
Query: 267 GLET-AKDDSQAAAIAENNNSIMSFFKTLVSPNKAETKKDPEDTGAEKSPTTSADLKSDK 325
++ ++ + +A S+ S K + + +A+T + ED+G+ + + S +
Sbjct: 749 KVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPE-EDSGSSEEESDSEE----- 802
Query: 326 ANFTSQETQGAGKNSKGCNPSGHTQSVTTP-EPAKEGTKE--------KSGPTSLPLGKL 376
ET K PSG T + PAKE ++ K+GP++ GK
Sbjct: 803 ----EAETLAQVK------PSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGK- 851
Query: 377 FWKKSVKEDSVPTGAEENVVCESPVEIIKSKEVESALQTVDLNEGDAAPEPTEAKLKREE 436
++DS + E + E+P + ++ ++ L VD N A P T A+ +
Sbjct: 852 ------QDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQ-AQAA 904
Query: 437 SKPRTSLMAFLRQMSVKGDGGITHSEEINGKDSSCQTSDSTEKTITPPEPEPTGAPQKGK 496
S PR A + + + + E++ + C T +T P P AP+
Sbjct: 905 STPR---KARASESTARSSSSESEDEDVI-PATQCLTPGIRTNVVTMPTAHPRIAPKASM 960
Query: 497 EGSSKDKKSA 506
G+S K+S+
Sbjct: 961 AGASSSKESS 970
Score = 43.5 bits (101), Expect = 5e-04
Identities = 109/515 (21%), Positives = 191/515 (37%), Gaps = 57/515 (11%)
Query: 56 TDNVATSSPETTEISAV--ADANGKNLGKEAKPEAPAAKSRFFLMLSRPVPGRTGDQAAD 113
++ + S ET A+ A A+GK + APA +S P PG+TG A
Sbjct: 266 SEESSDSEEETPAAKALLQAKASGKT-SQVGAASAPAKESPRKGAAPAP-PGKTGPAVAK 323
Query: 114 SSLGSVKLDVSSNKAPANKDPSESWTLPVAAGP-GQDTDKTPGHAPAQDKVLSAARDPTL 172
+ G + D S+ ++ + P A P G+ APA++ A
Sbjct: 324 AQAGKREEDSQSSSEESDSEEEA----PAQAKPSGKAPQVRAASAPAKESPRKGAAPAP- 378
Query: 173 LPPETGGAGGEAPSKPKDSSFFDKFFKLDKGQEKVPGDSQQEAKRAEHQDKVDEVPG--- 229
P +TG A + ++ + D +E + + + K +V
Sbjct: 379 -PRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGM 437
Query: 230 --LSGQSDDVPAGK------DIVDGKEKEGQELGTADCSVPGDPEGLETAKDDSQAAAIA 281
L + VP GK GK +E E + + S D E + TA +Q ++
Sbjct: 438 GPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGE-VPTAVAPAQEKSLG 496
Query: 282 ENNNSIMSFFKTLVSPNKA-------ETKKDPEDTGAEKSPTTSADLKSDKANFTSQETQ 334
+ + P KA + +K +++ + + + SAD + A T+ + +
Sbjct: 497 NILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAK 556
Query: 335 GAGK--NSKGCNPSGHTQSVTTPEPAKEGTK--EKSGPTSLPLGKLFWKKSVKEDSVPTG 390
A K +K C +T + P + GT+ K+G + P G +V G
Sbjct: 557 PALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGS--------SPAVAGG 608
Query: 391 AEENVVCESPVEIIKSKEVESAL-----QTVDLNEG---DAAPEPTEAKLKREESK--PR 440
+ S E S+E ++ L Q + +G AA P + L + + P
Sbjct: 609 TQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPG 668
Query: 441 TSLMAFLRQMSVKGDGGITHSEEINGKD---SSCQTSDSTEKTITPPEPEPTGAPQ-KGK 496
+ + + K + + EE + ++ S Q S +KT P AP KG
Sbjct: 669 KTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGT 728
Query: 497 EGSSKDKKSAAEMNKQKSNKQEAKEPAQCTEQATV 531
+ +AA KQ+S + K P + + +TV
Sbjct: 729 ISAPGKVVTAAAQAKQRS-PSKVKPPVRNPQNSTV 762
Score = 36.6 bits (83), Expect = 0.066
Identities = 95/452 (21%), Positives = 158/452 (34%), Gaps = 67/452 (14%)
Query: 50 LGISVKTDNVATSSPETTEISAVADANGKNLGKEAKPEAPAAKSRFFLMLSRPV------ 103
+G +V T A + PE S+ +++ + + P+ K+ P
Sbjct: 773 VGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRK 832
Query: 104 ------PGRTGDQAA-----DSSLGSVKLDVSSNKAPANKDPSESWTLPVAAGPGQDTDK 152
PG+TG AA D S S + S +APA ++ P+ +
Sbjct: 833 GAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPA 892
Query: 153 TPGHAPAQDKVLSAARDPTLLPPETGGAGGEAPSKPKDSSFFDKFFKLDKGQEKVPGDSQ 212
P PAQ + S R E+ + S+ +D + Q PG
Sbjct: 893 GPAATPAQAQAASTPRKARA--SESTARSSSSESEDEDV--------IPATQCLTPGIRT 942
Query: 213 QEAKRAEHQDKVDEVPGLSGQSDDVPAGKDIVDGKEKEGQELGTAD---CSVPGDPEGLE 269
++ ++G S + + I DGK++EG + S+P L+
Sbjct: 943 NVVTMPTAHPRIAPKASMAGASSSKESSR-ISDGKKQEGPATQVSKKNPASLPLTQAALK 1001
Query: 270 T----AKDDSQAAAIAENNNSIMSFFKTL--VSP----------NKAETKKDPEDTGAEK 313
A + A + ++ + S TL SP NK K PE A K
Sbjct: 1002 VLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATK 1061
Query: 314 SPTTSADLKSDKANFTSQETQGAG-KNSKGCNPSGHTQSVT---TPEPAKEGTKEK---- 365
+P +S D + + + E G G + +K + G T S T E A E +++
Sbjct: 1062 APESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAP 1121
Query: 366 -----SG---PTSLPLGKLFWKKSVKEDSVPTGAEENVVCESPVEIIKSKEVESALQTVD 417
SG P P K + K DS P+ + + P ++K ++A
Sbjct: 1122 SQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSP 1181
Query: 418 LNEGDAAPEPTEAKLKREESK----PRTSLMA 445
G A T + R+ K P+ S +A
Sbjct: 1182 KTGGKEAASGTTPQKSRKPKKGAGNPQASTLA 1213
Score = 35.4 bits (80), Expect = 0.15
Identities = 88/410 (21%), Positives = 139/410 (33%), Gaps = 81/410 (19%)
Query: 125 SNKAPANKDPSESWTLPVAAGPGQDTDKTPGHAPAQDKVLSAARDPTLLPPETGGAGGE- 183
+ KAP + D SE + ++G +D + G A + +R TL+ ET E
Sbjct: 1059 ATKAPESSDDSED-SSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVE-ETAAESSED 1116
Query: 184 ---APSKPKDSSFFDKFFKLDKGQEKVPGDSQQEAKRAEHQDKVDEVPGLSGQSDDVPAG 240
APS+ S + PG + ++ ++ K+D P +S A
Sbjct: 1117 DVVAPSQSLLSGYM------------TPGLTPANSQASKATPKLDSSPSVSSTL----AA 1160
Query: 241 KDIVDGKE--KEGQELGTADCSVPGDPEGLETAKDDS----------QAAAIAENNNSIM 288
KD DGK+ K Q G G T S QA+ +A +N
Sbjct: 1161 KDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQ 1220
Query: 289 SFFKTLVSPNKAETKKDPEDTGAEKSPTTSADLKSDKANFTSQETQGAGKNSKGCNPSGH 348
N+A+ + K T + + K T++E+ G S+ SG
Sbjct: 1221 CLLGQPWPLNEAQVQ-----ASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGD 1275
Query: 349 TQSVTTPEPAKEGTKEKSGPTSLPLGKLFWKKSVKEDSVPTGAEENVVCESPVEIIKSKE 408
+ TP K K+K G G E +V E K K
Sbjct: 1276 QPAARTPRSKK---KKKLGAGE-------------------GGEASVSPEKTSTTSKGKA 1313
Query: 409 VESALQTVDLNEGDAAPEPTEAKLKREESK--PRTSLMAFLRQMSVKGDGGITHSEEING 466
D GD + + L + +K P L KG G + ++ N
Sbjct: 1314 KR------DKASGDVKEKKGKGSLGSQGAKDEPEEELQ--------KGMGTVEGGDQSNP 1359
Query: 467 KDSSCQTSDSTEKTITPPEPEPTGAPQKGKEGSSKDKKSAAEMNKQKSNK 516
K + K + E +K K+ S+KD +S ++ K+K K
Sbjct: 1360 KSKKEKKKSDKRKK----DKEKKEKKKKAKKASTKDSESPSQKKKKKKKK 1405
Score = 32.3 bits (72), Expect = 1.2
Identities = 63/260 (24%), Positives = 93/260 (35%), Gaps = 25/260 (9%)
Query: 299 KAETKKDPEDTGAEKSPTTSADLKSDKANFTSQETQGAGK--NSKGCNPSGHTQSVTTPE 356
+AET K + S ADL S ET+ AGK NS +G T +
Sbjct: 95 EAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSG 154
Query: 357 PAKEGTKEKSGPTSLPLGKLFWKKSVKEDSVPT-GAEENVVCESPVEIIKSKEVESALQT 415
+ + E S T+L ++ +E SVP GA S + S E S+
Sbjct: 155 KSPRKSAEPSANTTLV------SETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSS--- 205
Query: 416 VDLNEGDAAPEPTEAKLK-REESKPRTSLMAFLRQMSVKGDGGITHSEEINGK------D 468
+E D + +E L+ R S P + G G S+ GK
Sbjct: 206 -SSDETDVEVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSES 264
Query: 469 SSCQTSDSTEKTITPPEPEPTGAPQKGKEGSSKDKKSAAEMNKQKSNKQEAKEPAQCTEQ 528
SS ++SDS E+T P Q G + +A+ K+ K A P T
Sbjct: 265 SSEESSDSEEET-----PAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGP 319
Query: 529 ATVDTNSLQNGDKLQKRPEK 548
A + + + Q E+
Sbjct: 320 AVAKAQAGKREEDSQSSSEE 339
>gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1
[Homo sapiens]
Length = 651
Score = 50.1 bits (118), Expect = 6e-06
Identities = 80/378 (21%), Positives = 149/378 (39%), Gaps = 38/378 (10%)
Query: 171 TLLPPETGGAGGEAPSKPKDSSFFDKFFKLDKGQEKVPGDSQQEAKRAEHQDKVDEVPGL 230
T L ++ GG + P+ ++ K +K P S E ++++ E
Sbjct: 125 TPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKSSSETNPE 184
Query: 231 SGQSDDVPAGKDIVDGKE-KEGQELGTADCSVPGDPE-GLETAKDDSQAAAIAENNNSIM 288
S S V D K+ K ++ T +P+ L+ +K + + + NS+
Sbjct: 185 SQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLN 244
Query: 289 SFFKTLVSPNKAETKK-DPEDTGAEKSPTTSADLKSDKANFTSQETQGAGKNSKGCNPSG 347
F LV + E+ D ++ + + LK K +T ++T+ KN+K S
Sbjct: 245 VDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTK--YTKKDTK---KNAK---KSS 296
Query: 348 HTQSVTTPEPAKEGTKEKSGPTSLPLGKLFWKKSVKEDSVPTGAEENVVCESPVEIIKSK 407
+S + + K+ K K + K KK VK+D+ T AE + + K K
Sbjct: 297 DAESEDSKDAKKDSKKVKKN-----VKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDK 351
Query: 408 ----------EVESALQTVDLNEGDAAPEPTEAK-----LKREESKPRTSLMAFLRQMSV 452
+ + ++ D GDA +++ K ++ K + F
Sbjct: 352 KKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSES 411
Query: 453 KGDGGITHSEEINGKDSSC---QTSDSTEKTITPPEPEPTGAPQKGKEGSSKDKKSAAEM 509
+ + + +E K S + S ++ T + EP G +KGK KD+K +
Sbjct: 412 ELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGK----KDEKKGKKD 467
Query: 510 NKQKSNKQEAKEPAQCTE 527
+K+ K++AK+ A+ TE
Sbjct: 468 SKKDDKKKDAKKNAESTE 485
Score = 33.9 bits (76), Expect = 0.43
Identities = 45/284 (15%), Positives = 99/284 (34%), Gaps = 50/284 (17%)
Query: 271 AKDDSQAAAIAENNNSIMSFFKTLVSPNKAETKKDPEDTGAEKSPTTSA-----DLKSDK 325
+KD+ + +++ + T + +K A+K+P S+ KS
Sbjct: 118 SKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKS 177
Query: 326 ANFTSQETQGAGKNSKGCNPSGHTQSVTTPEPAKEGTKEKSGPTSLPLGKLFWKKSVKED 385
++ T+ E+Q + SK C+ S + + E K+ P KK +K
Sbjct: 178 SSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNP----------KKDLKRS 227
Query: 386 SVPTGAEENVVCESPVEIIKSKEVESALQTVDLNEGDAAPEPTEAKLKREESKPRTSLMA 445
+ E+ + + L V ++ +
Sbjct: 228 KTSNDPISEICSENSLNV-------DFLMLVGQSDDE----------------------- 257
Query: 446 FLRQMSVKGDGGITHSEEINGKDSSCQTSDSTEKTITPPEPEPTGAPQKGKEGSSKDKKS 505
S+ D + + + N K+ S + + T+K + + A + + + KD K
Sbjct: 258 -----SINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKK 312
Query: 506 AAEMNKQKSNKQEAKEPAQCTEQATVDTNSLQNGDKLQKRPEKR 549
+ K+ K++ K+ + T+ + D+ + K K+ K+
Sbjct: 313 VKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKK 356
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 48.9 bits (115), Expect = 1e-05
Identities = 68/311 (21%), Positives = 123/311 (39%), Gaps = 43/311 (13%)
Query: 244 VDGKEKEGQELGTA---DCSVPGDPEGLETAKD-DSQAAAIAENNNSIMSFFKTLVSPNK 299
V+ ++ E +E TA + +V E E A++ + + A E + S K K
Sbjct: 462 VEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVK 521
Query: 300 AETKKDPEDTGAEKSPTTSADLKSDKANFTSQETQGAGKNSKGCNPSGHTQSVTTPEPAK 359
E + E+ G E+ KSD+A E +G+ + +G G T++ E A+
Sbjct: 522 EEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAE 581
Query: 360 EGTKEKSGPTSLPLGKLFWKKSVKEDSVPTGAEENVVCESPVEIIKSKEVESALQTVDLN 419
KE +K V+E S +E +V ++ VE K ++ +S + +
Sbjct: 582 --AKE--------------EKKVEEKSEEVATKEELVADAKVE--KPEKAKSPVPKSPVE 623
Query: 420 EGDAAPEPTEAKLKREESKPRTSLMAFLRQMSVKGDGGITHSEEINGKDSSCQTSDSTEK 479
E +P P ++ +S S + KG + S S S EK
Sbjct: 624 EKGKSPVPKSPVEEKGKSPVPKS------PVEEKGKSPVPKSPVEEKGKSPVSKSPVEEK 677
Query: 480 TITPPEPEPTGAPQKGKEGSSKDKKSAAEMNKQKSNKQEAKEPAQCTEQATVDTNSLQNG 539
+P P ++ KS AE+ K + ++E KE + ++ V+ +
Sbjct: 678 AKSPVPKSPV-----------EEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVE----KKE 722
Query: 540 DKLQKRPEKRQ 550
+K + PEK++
Sbjct: 723 EKPKDVPEKKK 733
Score = 44.3 bits (103), Expect = 3e-04
Identities = 64/343 (18%), Positives = 137/343 (39%), Gaps = 22/343 (6%)
Query: 210 DSQQEAKRAEHQDKVDEVPGLSGQSDDVPAGKDIVDGKEKEGQELGTADCSVPGDP-EGL 268
+ ++E + + +++ ++ S Q+++ + K+ KE+ QE G + G+ E
Sbjct: 524 EGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAK 583
Query: 269 ETAKDDSQAAAIAENNNSIMSFFKTLVSPNKAET---KKDPEDTGAEKSPTTSADLKSDK 325
E K + ++ +A + + P KA++ K E+ G P + + K K
Sbjct: 584 EEKKVEEKSEEVATKEELVAD--AKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKG-K 640
Query: 326 ANFTSQETQGAGKNSKGCNPSGHT-QSVTTPEPAKEGTKE-------KSGPTSLPLGKLF 377
+ + GK+ +P +S + P +E K + + +GK
Sbjct: 641 SPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGE 700
Query: 378 WKKSVKEDSVPTGAEENVVC--ESPVEIIKSKEVESALQTVDLNEGDAAPEPTEAKLKRE 435
K+ +++ EE V E P ++ + K+ ES ++ + E + + L++E
Sbjct: 701 QKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKE 760
Query: 436 ESKPRTSLMAFLRQMSVKGDGGITHSEEINGKDSSCQTSDSTEKTITPPEPEPTGAPQKG 495
+ L + G+GG SEE G D + S + + Q+
Sbjct: 761 TKEEGKPLQQEKEKEKAGGEGG---SEE-EGSDKGAKGSRKEDIAVNGEVEGKEEVEQET 816
Query: 496 KE-GSSKDKKSAAEMNKQKSNKQEAKEPAQCTEQATVDTNSLQ 537
KE GS ++++ N + + K+ +E+ V T +++
Sbjct: 817 KEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVE 859
Score = 38.1 bits (87), Expect = 0.023
Identities = 84/375 (22%), Positives = 137/375 (36%), Gaps = 80/375 (21%)
Query: 12 EDQENEPEAETYQDNASALNGVPVVVSTHTVQHLEEVDLGISVKTDNVATSSPETTEISA 71
E +E E EAE + A A + + + K++ VAT
Sbjct: 565 EQEEGETEAEAEGEEAEA-----------------KEEKKVEEKSEEVATKE------EL 601
Query: 72 VADANGKNLGKEAKPEAPAAKSRFFLMLSRPVPGRTGDQAADSSLGSVKLDVSSNKAPAN 131
VADA + K K ++P KS PVP ++ S + ++ K+P
Sbjct: 602 VADAK---VEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVE-EKGKSPVP 657
Query: 132 KDP-SESWTLPVAAGPGQDTDKTPGHAPAQDKVLSAARDPTLLPPETGGAGGEAPSKPKD 190
K P E PV+ P ++ K+P ++ S A G G + + K+
Sbjct: 658 KSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAE---------VGKGEQKEEEEKE 708
Query: 191 SSFFDKFFKLDKGQEK---VPGDSQQEAKRAE---------------HQDKVDEVPG--L 230
K K++K +EK VP + E+ E H +K + G L
Sbjct: 709 VKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPL 768
Query: 231 SGQSDDVPAGKDIVDGKEKEGQELGT-----ADCSVPGDPEGLETAKDDSQAAAIAENNN 285
+ + AG + G E+EG + G D +V G+ EG E + +++
Sbjct: 769 QQEKEKEKAGGE--GGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEE 826
Query: 286 SIMSFFKTLVSPNKAETKKDPEDTGAEKSPTTSADLKSDKANFTSQETQGAGKNSKGCNP 345
K +V+ N + E G +KS K+ + TS+ GA K
Sbjct: 827 ------KGVVT-NGLDLSPADEKKGGDKSEEKVVVTKTVE-KITSEGGDGATKYI----- 873
Query: 346 SGHTQSVTTPEPAKE 360
T+SVT + +E
Sbjct: 874 ---TKSVTVTQKVEE 885
Score = 31.6 bits (70), Expect = 2.1
Identities = 32/167 (19%), Positives = 71/167 (42%), Gaps = 17/167 (10%)
Query: 429 EAKLKREESKPRTSLMAFLRQMSV-----KGDGGITHSEEINGKDSSCQTSDSTEKTITP 483
E K++ E+S+ +L A +++V K + EE ++ S K P
Sbjct: 459 ETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAP 518
Query: 484 PEPEPTGAPQKGK---EGSSKDKKSAAEMNKQKSNKQEAKEPAQCTEQATVDTNSLQNGD 540
E G ++ + E +D+ + ++ ++ +++E + EQ +T + G+
Sbjct: 519 EVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGE 578
Query: 541 ----KLQKRPEKRQQSLGGFFKGLGPKRMLDAQVQTDPVSIGPVGKS 583
K +K+ E++ + + + + DA+V+ + PV KS
Sbjct: 579 EAEAKEEKKVEEKSEEV-----ATKEELVADAKVEKPEKAKSPVPKS 620
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 48.9 bits (115), Expect = 1e-05
Identities = 68/311 (21%), Positives = 123/311 (39%), Gaps = 43/311 (13%)
Query: 244 VDGKEKEGQELGTA---DCSVPGDPEGLETAKD-DSQAAAIAENNNSIMSFFKTLVSPNK 299
V+ ++ E +E TA + +V E E A++ + + A E + S K K
Sbjct: 86 VEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVK 145
Query: 300 AETKKDPEDTGAEKSPTTSADLKSDKANFTSQETQGAGKNSKGCNPSGHTQSVTTPEPAK 359
E + E+ G E+ KSD+A E +G+ + +G G T++ E A+
Sbjct: 146 EEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAE 205
Query: 360 EGTKEKSGPTSLPLGKLFWKKSVKEDSVPTGAEENVVCESPVEIIKSKEVESALQTVDLN 419
KE +K V+E S +E +V ++ VE K ++ +S + +
Sbjct: 206 --AKE--------------EKKVEEKSEEVATKEELVADAKVE--KPEKAKSPVPKSPVE 247
Query: 420 EGDAAPEPTEAKLKREESKPRTSLMAFLRQMSVKGDGGITHSEEINGKDSSCQTSDSTEK 479
E +P P ++ +S S + KG + S S S EK
Sbjct: 248 EKGKSPVPKSPVEEKGKSPVPKS------PVEEKGKSPVPKSPVEEKGKSPVSKSPVEEK 301
Query: 480 TITPPEPEPTGAPQKGKEGSSKDKKSAAEMNKQKSNKQEAKEPAQCTEQATVDTNSLQNG 539
+P P ++ KS AE+ K + ++E KE + ++ V+ +
Sbjct: 302 AKSPVPKSPV-----------EEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVE----KKE 346
Query: 540 DKLQKRPEKRQ 550
+K + PEK++
Sbjct: 347 EKPKDVPEKKK 357
Score = 44.3 bits (103), Expect = 3e-04
Identities = 64/343 (18%), Positives = 137/343 (39%), Gaps = 22/343 (6%)
Query: 210 DSQQEAKRAEHQDKVDEVPGLSGQSDDVPAGKDIVDGKEKEGQELGTADCSVPGDP-EGL 268
+ ++E + + +++ ++ S Q+++ + K+ KE+ QE G + G+ E
Sbjct: 148 EGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAK 207
Query: 269 ETAKDDSQAAAIAENNNSIMSFFKTLVSPNKAET---KKDPEDTGAEKSPTTSADLKSDK 325
E K + ++ +A + + P KA++ K E+ G P + + K K
Sbjct: 208 EEKKVEEKSEEVATKEELVAD--AKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKG-K 264
Query: 326 ANFTSQETQGAGKNSKGCNPSGHT-QSVTTPEPAKEGTKE-------KSGPTSLPLGKLF 377
+ + GK+ +P +S + P +E K + + +GK
Sbjct: 265 SPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGE 324
Query: 378 WKKSVKEDSVPTGAEENVVC--ESPVEIIKSKEVESALQTVDLNEGDAAPEPTEAKLKRE 435
K+ +++ EE V E P ++ + K+ ES ++ + E + + L++E
Sbjct: 325 QKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKE 384
Query: 436 ESKPRTSLMAFLRQMSVKGDGGITHSEEINGKDSSCQTSDSTEKTITPPEPEPTGAPQKG 495
+ L + G+GG SEE G D + S + + Q+
Sbjct: 385 TKEEGKPLQQEKEKEKAGGEGG---SEE-EGSDKGAKGSRKEDIAVNGEVEGKEEVEQET 440
Query: 496 KE-GSSKDKKSAAEMNKQKSNKQEAKEPAQCTEQATVDTNSLQ 537
KE GS ++++ N + + K+ +E+ V T +++
Sbjct: 441 KEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVE 483
Score = 38.1 bits (87), Expect = 0.023
Identities = 84/375 (22%), Positives = 137/375 (36%), Gaps = 80/375 (21%)
Query: 12 EDQENEPEAETYQDNASALNGVPVVVSTHTVQHLEEVDLGISVKTDNVATSSPETTEISA 71
E +E E EAE + A A + + + K++ VAT
Sbjct: 189 EQEEGETEAEAEGEEAEA-----------------KEEKKVEEKSEEVATKE------EL 225
Query: 72 VADANGKNLGKEAKPEAPAAKSRFFLMLSRPVPGRTGDQAADSSLGSVKLDVSSNKAPAN 131
VADA + K K ++P KS PVP ++ S + ++ K+P
Sbjct: 226 VADAK---VEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVE-EKGKSPVP 281
Query: 132 KDP-SESWTLPVAAGPGQDTDKTPGHAPAQDKVLSAARDPTLLPPETGGAGGEAPSKPKD 190
K P E PV+ P ++ K+P ++ S A G G + + K+
Sbjct: 282 KSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAE---------VGKGEQKEEEEKE 332
Query: 191 SSFFDKFFKLDKGQEK---VPGDSQQEAKRAE---------------HQDKVDEVPG--L 230
K K++K +EK VP + E+ E H +K + G L
Sbjct: 333 VKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPL 392
Query: 231 SGQSDDVPAGKDIVDGKEKEGQELGT-----ADCSVPGDPEGLETAKDDSQAAAIAENNN 285
+ + AG + G E+EG + G D +V G+ EG E + +++
Sbjct: 393 QQEKEKEKAGGE--GGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEE 450
Query: 286 SIMSFFKTLVSPNKAETKKDPEDTGAEKSPTTSADLKSDKANFTSQETQGAGKNSKGCNP 345
K +V+ N + E G +KS K+ + TS+ GA K
Sbjct: 451 ------KGVVT-NGLDLSPADEKKGGDKSEEKVVVTKTVE-KITSEGGDGATKYI----- 497
Query: 346 SGHTQSVTTPEPAKE 360
T+SVT + +E
Sbjct: 498 ---TKSVTVTQKVEE 509
Score = 31.6 bits (70), Expect = 2.1
Identities = 32/167 (19%), Positives = 71/167 (42%), Gaps = 17/167 (10%)
Query: 429 EAKLKREESKPRTSLMAFLRQMSV-----KGDGGITHSEEINGKDSSCQTSDSTEKTITP 483
E K++ E+S+ +L A +++V K + EE ++ S K P
Sbjct: 83 ETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAP 142
Query: 484 PEPEPTGAPQKGK---EGSSKDKKSAAEMNKQKSNKQEAKEPAQCTEQATVDTNSLQNGD 540
E G ++ + E +D+ + ++ ++ +++E + EQ +T + G+
Sbjct: 143 EVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGE 202
Query: 541 ----KLQKRPEKRQQSLGGFFKGLGPKRMLDAQVQTDPVSIGPVGKS 583
K +K+ E++ + + + + DA+V+ + PV KS
Sbjct: 203 EAEAKEEKKVEEKSEEV-----ATKEELVADAKVEKPEKAKSPVPKS 244
>gi|34335264 zinc finger, MYND-type containing 8 isoform c [Homo
sapiens]
Length = 1135
Score = 48.1 bits (113), Expect = 2e-05
Identities = 62/282 (21%), Positives = 117/282 (41%), Gaps = 37/282 (13%)
Query: 266 EGLETAKDDSQAAAIAENNNSIMSFFKTLVSPNKAETKKDPEDT----GAEKSPTTSADL 321
E + TA + S + ++++S + +S ++ ++K +PEDT G + SA
Sbjct: 573 EDVYTAVEHSDSEDSEKSDSSDSEY----ISDDEQKSKNEPEDTEDKEGCQMDKEPSAVK 628
Query: 322 KSDKANFT---SQETQGAGKNSKGCNPSGHTQSVTTPEPAKEGTKEKSGPTSLPL-GKLF 377
K K +E + S+ +P G + +PEP K+ + EK+ P+ P+ KL
Sbjct: 629 KKPKPTNPVEIKEELKSTSPASEKADP-GAVKDKASPEPEKDFS-EKAKPSPHPIKDKLK 686
Query: 378 WKKSVKEDSVPTGAEENVVCESPVEIIKSKEVESALQTVDLNEGDAAPEPTEAKLKREES 437
K +V G + +S E++ +DL E + E + K + +E
Sbjct: 687 GKDETDSPTVHLGLDS----DSESELV-----------IDLGEDHSGREGRKNKKEPKEP 731
Query: 438 KPRTSLMAFLRQMSVKGDGG-------ITHSEEINGKDSSCQTSDSTEKTITPPEPEPTG 490
P+ ++ + G S + + ++ TS S+ T+T P P TG
Sbjct: 732 SPKQDVVGKTPPSTTVGSHSPPETPVLTRSSAQTSAAGATATTSTSSTVTVTAPAPAATG 791
Query: 491 AP-QKGKEGSSKDKKSAAEMNKQKSNKQEAKEPAQCTEQATV 531
+P +K + K+ A + S+ + KE Q +T+
Sbjct: 792 SPVKKQRPLLPKETAPAVQRVVWNSSTVQQKEITQSPSTSTI 833
>gi|34335262 zinc finger, MYND-type containing 8 isoform a [Homo
sapiens]
Length = 1188
Score = 48.1 bits (113), Expect = 2e-05
Identities = 62/282 (21%), Positives = 117/282 (41%), Gaps = 37/282 (13%)
Query: 266 EGLETAKDDSQAAAIAENNNSIMSFFKTLVSPNKAETKKDPEDT----GAEKSPTTSADL 321
E + TA + S + ++++S + +S ++ ++K +PEDT G + SA
Sbjct: 598 EDVYTAVEHSDSEDSEKSDSSDSEY----ISDDEQKSKNEPEDTEDKEGCQMDKEPSAVK 653
Query: 322 KSDKANFT---SQETQGAGKNSKGCNPSGHTQSVTTPEPAKEGTKEKSGPTSLPL-GKLF 377
K K +E + S+ +P G + +PEP K+ + EK+ P+ P+ KL
Sbjct: 654 KKPKPTNPVEIKEELKSTSPASEKADP-GAVKDKASPEPEKDFS-EKAKPSPHPIKDKLK 711
Query: 378 WKKSVKEDSVPTGAEENVVCESPVEIIKSKEVESALQTVDLNEGDAAPEPTEAKLKREES 437
K +V G + +S E++ +DL E + E + K + +E
Sbjct: 712 GKDETDSPTVHLGLDS----DSESELV-----------IDLGEDHSGREGRKNKKEPKEP 756
Query: 438 KPRTSLMAFLRQMSVKGDGG-------ITHSEEINGKDSSCQTSDSTEKTITPPEPEPTG 490
P+ ++ + G S + + ++ TS S+ T+T P P TG
Sbjct: 757 SPKQDVVGKTPPSTTVGSHSPPETPVLTRSSAQTSAAGATATTSTSSTVTVTAPAPAATG 816
Query: 491 AP-QKGKEGSSKDKKSAAEMNKQKSNKQEAKEPAQCTEQATV 531
+P +K + K+ A + S+ + KE Q +T+
Sbjct: 817 SPVKKQRPLLPKETAPAVQRVVWNSSTVQQKEITQSPSTSTI 858
>gi|34335266 zinc finger, MYND-type containing 8 isoform b [Homo
sapiens]
Length = 1160
Score = 48.1 bits (113), Expect = 2e-05
Identities = 62/282 (21%), Positives = 117/282 (41%), Gaps = 37/282 (13%)
Query: 266 EGLETAKDDSQAAAIAENNNSIMSFFKTLVSPNKAETKKDPEDT----GAEKSPTTSADL 321
E + TA + S + ++++S + +S ++ ++K +PEDT G + SA
Sbjct: 598 EDVYTAVEHSDSEDSEKSDSSDSEY----ISDDEQKSKNEPEDTEDKEGCQMDKEPSAVK 653
Query: 322 KSDKANFT---SQETQGAGKNSKGCNPSGHTQSVTTPEPAKEGTKEKSGPTSLPL-GKLF 377
K K +E + S+ +P G + +PEP K+ + EK+ P+ P+ KL
Sbjct: 654 KKPKPTNPVEIKEELKSTSPASEKADP-GAVKDKASPEPEKDFS-EKAKPSPHPIKDKLK 711
Query: 378 WKKSVKEDSVPTGAEENVVCESPVEIIKSKEVESALQTVDLNEGDAAPEPTEAKLKREES 437
K +V G + +S E++ +DL E + E + K + +E
Sbjct: 712 GKDETDSPTVHLGLDS----DSESELV-----------IDLGEDHSGREGRKNKKEPKEP 756
Query: 438 KPRTSLMAFLRQMSVKGDGG-------ITHSEEINGKDSSCQTSDSTEKTITPPEPEPTG 490
P+ ++ + G S + + ++ TS S+ T+T P P TG
Sbjct: 757 SPKQDVVGKTPPSTTVGSHSPPETPVLTRSSAQTSAAGATATTSTSSTVTVTAPAPAATG 816
Query: 491 AP-QKGKEGSSKDKKSAAEMNKQKSNKQEAKEPAQCTEQATV 531
+P +K + K+ A + S+ + KE Q +T+
Sbjct: 817 SPVKKQRPLLPKETAPAVQRVVWNSSTVQQKEITQSPSTSTI 858
>gi|212276104 leucine rich repeat (in FLII) interacting protein 1
isoform 5 [Homo sapiens]
Length = 752
Score = 47.4 bits (111), Expect = 4e-05
Identities = 88/391 (22%), Positives = 145/391 (37%), Gaps = 65/391 (16%)
Query: 195 DKFFKLDKGQEKVPGDSQQEAKRAEHQDKVDEVPGLSGQSDDVPAGKDIV--DGKEKEGQ 252
D + DK +VP + + + ++ ++ + + +VPA V D E+EG+
Sbjct: 392 DTVYHDDKCMVEVPQELETSTGHSLEKEFTNQE---AAEPKEVPAHSTEVGRDHNEEEGE 448
Query: 253 ELGTAD-----CSVPGDPEGLETAKDDSQAAAIAENNNSIMSFFKTLVSPNKAETKKDPE 307
E G D VPG P G E ++ P+ +T+ +P
Sbjct: 449 ETGLRDEKPIKTEVPGSPAGTEGNCQEA-------------------TGPSTVDTQNEPL 489
Query: 308 DTGAEKSPTTSADLKSDKANFTSQETQGAGKNSKGCNPSGHTQSVTTPEPAKEGTKEKSG 367
D K P KSD+ +Q KN K N +S E K+ KE +
Sbjct: 490 DM---KEPDEE---KSDQQGEALDSSQKKTKNKKKKNKK--KKSPVPVETLKDVKKELTY 541
Query: 368 PTSLPLGKLFWKKSVKEDSVPTGAE-ENVVCESPVEIIKSKEVESALQTVDLNEGDAAPE 426
+ L ++ ++ VK + E +N V E+P K K + + VD E
Sbjct: 542 QNT-DLSEIKEEEQVKSTDRKSAVEAQNEVTENP----KQKIAAESSENVDCPENPKIK- 595
Query: 427 PTEAKLKREESKPRTSLMAFL--------RQMSVKGDGGITHSEEINGKDSSCQTSDSTE 478
+ KL +E +T+ L +V+ G EE++ +
Sbjct: 596 -LDGKLDQEGDDVQTAAEEVLADGDTLDFEDDTVQSSGPRAGGEELDEGVAKDNAKIDGA 654
Query: 479 KTITPPEPEPTGAPQ---KGKEGSSKDKKSAAEMNKQKSNKQEAKEPAQCTEQATVDTNS 535
+P EP+ A + E S+D A E + + + E E T + +D+NS
Sbjct: 655 TQSSPAEPKSEDADRCTLPEHESPSQDISDACEA--ESTERCEMSEHPSQTVRKALDSNS 712
Query: 536 LQNGDKLQK-------RPEKRQQSLGGFFKG 559
L+N D PE R+ + GG KG
Sbjct: 713 LENDDLSAPGREPGHFNPESREDTRGGNEKG 743
>gi|212276096 leucine rich repeat (in FLII) interacting protein 1
isoform 3 [Homo sapiens]
Length = 808
Score = 47.4 bits (111), Expect = 4e-05
Identities = 88/391 (22%), Positives = 145/391 (37%), Gaps = 65/391 (16%)
Query: 195 DKFFKLDKGQEKVPGDSQQEAKRAEHQDKVDEVPGLSGQSDDVPAGKDIV--DGKEKEGQ 252
D + DK +VP + + + ++ ++ + + +VPA V D E+EG+
Sbjct: 448 DTVYHDDKCMVEVPQELETSTGHSLEKEFTNQE---AAEPKEVPAHSTEVGRDHNEEEGE 504
Query: 253 ELGTAD-----CSVPGDPEGLETAKDDSQAAAIAENNNSIMSFFKTLVSPNKAETKKDPE 307
E G D VPG P G E ++ P+ +T+ +P
Sbjct: 505 ETGLRDEKPIKTEVPGSPAGTEGNCQEA-------------------TGPSTVDTQNEPL 545
Query: 308 DTGAEKSPTTSADLKSDKANFTSQETQGAGKNSKGCNPSGHTQSVTTPEPAKEGTKEKSG 367
D K P KSD+ +Q KN K N +S E K+ KE +
Sbjct: 546 DM---KEPDEE---KSDQQGEALDSSQKKTKNKKKKNKK--KKSPVPVETLKDVKKELTY 597
Query: 368 PTSLPLGKLFWKKSVKEDSVPTGAE-ENVVCESPVEIIKSKEVESALQTVDLNEGDAAPE 426
+ L ++ ++ VK + E +N V E+P K K + + VD E
Sbjct: 598 QNT-DLSEIKEEEQVKSTDRKSAVEAQNEVTENP----KQKIAAESSENVDCPENPKIK- 651
Query: 427 PTEAKLKREESKPRTSLMAFL--------RQMSVKGDGGITHSEEINGKDSSCQTSDSTE 478
+ KL +E +T+ L +V+ G EE++ +
Sbjct: 652 -LDGKLDQEGDDVQTAAEEVLADGDTLDFEDDTVQSSGPRAGGEELDEGVAKDNAKIDGA 710
Query: 479 KTITPPEPEPTGAPQ---KGKEGSSKDKKSAAEMNKQKSNKQEAKEPAQCTEQATVDTNS 535
+P EP+ A + E S+D A E + + + E E T + +D+NS
Sbjct: 711 TQSSPAEPKSEDADRCTLPEHESPSQDISDACEA--ESTERCEMSEHPSQTVRKALDSNS 768
Query: 536 LQNGDKLQK-------RPEKRQQSLGGFFKG 559
L+N D PE R+ + GG KG
Sbjct: 769 LENDDLSAPGREPGHFNPESREDTRGGNEKG 799
>gi|212276070 leucine rich repeat (in FLII) interacting protein 1
isoform 4 [Homo sapiens]
Length = 784
Score = 47.4 bits (111), Expect = 4e-05
Identities = 88/391 (22%), Positives = 145/391 (37%), Gaps = 65/391 (16%)
Query: 195 DKFFKLDKGQEKVPGDSQQEAKRAEHQDKVDEVPGLSGQSDDVPAGKDIV--DGKEKEGQ 252
D + DK +VP + + + ++ ++ + + +VPA V D E+EG+
Sbjct: 424 DTVYHDDKCMVEVPQELETSTGHSLEKEFTNQE---AAEPKEVPAHSTEVGRDHNEEEGE 480
Query: 253 ELGTAD-----CSVPGDPEGLETAKDDSQAAAIAENNNSIMSFFKTLVSPNKAETKKDPE 307
E G D VPG P G E ++ P+ +T+ +P
Sbjct: 481 ETGLRDEKPIKTEVPGSPAGTEGNCQEA-------------------TGPSTVDTQNEPL 521
Query: 308 DTGAEKSPTTSADLKSDKANFTSQETQGAGKNSKGCNPSGHTQSVTTPEPAKEGTKEKSG 367
D K P KSD+ +Q KN K N +S E K+ KE +
Sbjct: 522 DM---KEPDEE---KSDQQGEALDSSQKKTKNKKKKNKK--KKSPVPVETLKDVKKELTY 573
Query: 368 PTSLPLGKLFWKKSVKEDSVPTGAE-ENVVCESPVEIIKSKEVESALQTVDLNEGDAAPE 426
+ L ++ ++ VK + E +N V E+P K K + + VD E
Sbjct: 574 QNT-DLSEIKEEEQVKSTDRKSAVEAQNEVTENP----KQKIAAESSENVDCPENPKIK- 627
Query: 427 PTEAKLKREESKPRTSLMAFL--------RQMSVKGDGGITHSEEINGKDSSCQTSDSTE 478
+ KL +E +T+ L +V+ G EE++ +
Sbjct: 628 -LDGKLDQEGDDVQTAAEEVLADGDTLDFEDDTVQSSGPRAGGEELDEGVAKDNAKIDGA 686
Query: 479 KTITPPEPEPTGAPQ---KGKEGSSKDKKSAAEMNKQKSNKQEAKEPAQCTEQATVDTNS 535
+P EP+ A + E S+D A E + + + E E T + +D+NS
Sbjct: 687 TQSSPAEPKSEDADRCTLPEHESPSQDISDACEA--ESTERCEMSEHPSQTVRKALDSNS 744
Query: 536 LQNGDKLQK-------RPEKRQQSLGGFFKG 559
L+N D PE R+ + GG KG
Sbjct: 745 LENDDLSAPGREPGHFNPESREDTRGGNEKG 775
>gi|38788260 bromodomain PHD finger transcription factor isoform 2
[Homo sapiens]
Length = 2903
Score = 46.6 bits (109), Expect = 6e-05
Identities = 50/193 (25%), Positives = 79/193 (40%), Gaps = 9/193 (4%)
Query: 205 EKVPGDSQQEAKRAEHQDKVDEVPGLSGQSDDVPAGKDIVDGKEKEGQELGTADCSVPGD 264
EK +++ ++K AE + E L SDD D GK +E E+G SV +
Sbjct: 577 EKDKNETENDSKDAEKNREEFEDQSLEKDSDDKTPDDDPEQGKSEEPTEVGDKGNSVSAN 636
Query: 265 PEGLETAKDDSQAAAIAENNNSIMSFFKTLVSPNKAETK---KDPEDTGAEKSPTTSADL 321
G T S+ + +E + + +T S N AE K + P+D E P + +
Sbjct: 637 -LGDNTTNATSEETSPSEGRSPVGCLSETPDSSNMAEKKVASELPQDVPEE--PNKTCES 693
Query: 322 KSDKANFTSQETQGAGKNSKGCNPSGHTQSVTTPEPAKEGTKEKSGPTSLP---LGKLFW 378
+ A TS + NS S ++S + + G +E P S+ +G
Sbjct: 694 SNTSATTTSIQPNLENSNSSSELNSSQSESAKAADDPENGERESHTPVSIQEEIVGDFKS 753
Query: 379 KKSVKEDSVPTGA 391
+KS E S GA
Sbjct: 754 EKSNGELSESPGA 766
Score = 37.0 bits (84), Expect = 0.050
Identities = 53/226 (23%), Positives = 80/226 (35%), Gaps = 43/226 (19%)
Query: 157 APAQDKVLSAAR------DPTLLPPETGGAGGEAPSKPKDSS-----FFDKFFKLDKGQE 205
A A +++L + R D P ET E + KD+ F D+ + D +
Sbjct: 550 AAANEEILESIRAKKGDIDNVKSPEETEKDKNETENDSKDAEKNREEFEDQSLEKDS-DD 608
Query: 206 KVPGDSQQEAKRAEHQDKVDEVPGLSGQSDDVPAGKDIVDGKEKEGQE-----LGTADCS 260
K P D ++ K E + D+ +S D + EG+ T D S
Sbjct: 609 KTPDDDPEQGKSEEPTEVGDKGNSVSANLGDNTTNATSEETSPSEGRSPVGCLSETPDSS 668
Query: 261 --------------VPGDP----EGLETAKDDSQAAAIAENNNSIMSFFKTLVSPNKAET 302
VP +P E T+ + EN+NS + A+
Sbjct: 669 NMAEKKVASELPQDVPEEPNKTCESSNTSATTTSIQPNLENSNSSSELNSS--QSESAKA 726
Query: 303 KKDPEDTGAEKSPTTS------ADLKSDKANFTSQETQGAGKNSKG 342
DPE+ E S D KS+K+N E+ GAGK + G
Sbjct: 727 ADDPENGERESHTPVSIQEEIVGDFKSEKSNGELSESPGAGKGASG 772
>gi|104526627 triadin [Homo sapiens]
Length = 729
Score = 44.7 bits (104), Expect = 2e-04
Identities = 76/347 (21%), Positives = 127/347 (36%), Gaps = 74/347 (21%)
Query: 199 KLDKGQEKVPGDSQQ-EAKRAEHQDKVDEVPGLSGQSDDVPAGKDIVDGKEKEGQELGTA 257
K D + K P + +Q + K+ E ++K E + VP+ K + E+ +E+G
Sbjct: 377 KEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAV 436
Query: 258 DC--SVPGDPEGLETAKDDSQAAAIAENNNSIMSFFKTLVSPNKAETKKDPEDTGAEKSP 315
+VPG E T + + E + S K P K + +K P EK P
Sbjct: 437 SIKKAVPGKKEEKTTKTVEQEIRK--EKSGKTSSILKDK-EPIKGKEEKVPASL-KEKEP 492
Query: 316 TTSADLKSDKANFTSQETQGAGKNSKGCNPSGHTQSVTTPEPAKEGTKEKSGPTSLPLGK 375
T D K KA GK K P + PEP K+++ P +
Sbjct: 493 ETKKDEKMSKA----------GKEVKPKPPQLQGKKEEKPEPQ---IKKEAKPAISEKVQ 539
Query: 376 LFWKKSVK-EDSVPTGAEENVVCESPVEIIKSKEVESALQTVDLNEGDAAPEPTEAKLKR 434
+ + VK E +V G E V + +K+ +E A P+PT+ R
Sbjct: 540 IHKQDIVKPEKTVSHGKPEEKVLKQ----VKAVTIEKT----------AKPKPTKKAEHR 585
Query: 435 EESKPRTSLMAFLRQMSVKGDGGITHSEEINGKDSSCQTSDSTEKTITPPEPEPTGAPQK 494
E P S+K D P+P P G +
Sbjct: 586 EREPP-----------SIKTD---------------------------KPKPTPKGTSEV 607
Query: 495 GKEGSSKDKKSAAEMNKQKSNKQEAKEPAQCTEQATVDTNSLQNGDK 541
+ G K + S E +K+K++ + +E T + ++ +++ +K
Sbjct: 608 TESGKKKTEISEKE-SKEKADMKHLREEKVSTRKESLQLHNVTKAEK 653
Score = 35.4 bits (80), Expect = 0.15
Identities = 79/347 (22%), Positives = 130/347 (37%), Gaps = 55/347 (15%)
Query: 242 DIVDGKEKEGQELGTADCSVPGDPEGLETAKDDSQAAAIAENNNSIMSFFKTLVSPNKAE 301
D+VD K + + DP L+ +D A+ E + I FF L +E
Sbjct: 69 DLVDYKNFSASSIA----KIGSDP--LKLVRD-----AMEETTDWIYGFFSLLSDIISSE 117
Query: 302 TKKDP---EDTGA---EKSPTTSADLKSDKANFTSQ-ETQGAGKNSKGCNPSGHTQSVTT 354
++D EDT ++ P ++ DK + E + K + G +
Sbjct: 118 DEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREK 177
Query: 355 PEPAKEGT-KEKSGPTSLPLGKLFWKKSVKEDSVPTGAEENVVCESPVEIIKSKEV-ESA 412
+P K+ T KEK P K K+ K + E+ + V+ K ++V ++A
Sbjct: 178 EKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKT---KKEVKGGKQEKVKQTA 234
Query: 413 LQTVDLNEGDAAPEPTEAKLKREESK-PRTSLMAFLRQMSVKGDGGITHSEEINGKDSSC 471
+ ++ + + P+ E K K SK + AF R M H + G+ +
Sbjct: 235 AKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMI----DIFVHGDLKPGQSPAI 290
Query: 472 QTSDSTEKTITPPEPEPTGAPQKGKEGS---------SKDKKSAAEMNKQKSNKQ----- 517
TE+ P P + KEG S+ KK E K+KS K+
Sbjct: 291 PPPLPTEQA---SRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDV 347
Query: 518 EAKEPAQCTE----------QATVDTNSLQNGDKLQKRPEKRQQSLG 554
E KEP + +E QA + + K K+P + +Q G
Sbjct: 348 EKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKG 394
Score = 32.3 bits (72), Expect = 1.2
Identities = 52/256 (20%), Positives = 95/256 (37%), Gaps = 17/256 (6%)
Query: 301 ETKKDPEDTGAEKSPTTSADLKSDKANFTSQETQGAGKNSKGCNPSGHTQSVTTPEPAKE 360
E +K E ++ P A K ET+ K K + ++ T E K
Sbjct: 166 EKEKGKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKE-VKG 224
Query: 361 GTKEKSGPTSLPLG---KLFWKKSVKEDSVPTGAEENVVCESPVEIIKSKEVESALQTVD 417
G +EK T+ + K K KED ++ E + + + D
Sbjct: 225 GKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKH---EQKDQYAFCRYMIDIFVHGD 281
Query: 418 LNEGDAA----PEPTEAKLKREESKPRTSLMAFLRQMSVKGDGGITHSEEINGKDSSCQT 473
L G + P PTE + S+P + A + K + E K+
Sbjct: 282 LKPGQSPAIPPPLPTE-----QASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIK 336
Query: 474 SDSTEKTITPPEPEPTGAPQKGKEGSSK-DKKSAAEMNKQKSNKQEAKEPAQCTEQATVD 532
S ++T E + G + K+G+ K ++AA+ +++K + ++ K+PA+ +
Sbjct: 337 KKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKK 396
Query: 533 TNSLQNGDKLQKRPEK 548
+ + K P+K
Sbjct: 397 QEKKEKHVEPAKSPKK 412
>gi|21493022 A kinase (PRKA) anchor protein 12 isoform 1 [Homo
sapiens]
Length = 1782
Score = 43.9 bits (102), Expect = 4e-04
Identities = 108/522 (20%), Positives = 186/522 (35%), Gaps = 81/522 (15%)
Query: 129 PANKDPSESWTLPVAAGPGQDTDKTPGHAPAQ---DKVLSAARDPTLLPPETGGAGGEAP 185
P D E VA+ +++ PA+ + LSA + LP E +G + P
Sbjct: 332 PEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGP 391
Query: 186 SKPKDSSFFDKFF--KLDKGQEKVPGD---SQQEAKRAEHQDKVDEVPG---------LS 231
S+ K + + F K++ QE+V + S E + E + +V+E G +
Sbjct: 392 SEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMD 451
Query: 232 GQSDDVPAGKDIVDGKE--------KEGQELGTADCSVPGDPEGL--ETAKDDSQAAAIA 281
+ + K++V KE +G +L + + PEG+ E SQ
Sbjct: 452 AEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKV 511
Query: 282 ENNNSIMSFFKTLVSPNKAETKKDPEDTGAEK----------SPTTSADLKSDKANFTSQ 331
+ + F T + + +K G E+ SP + + K + + + +
Sbjct: 512 QGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPE 571
Query: 332 ETQGAGKNSKG---CNPSGHTQSVTTPEPAKEGTKEKSGPTSLPLGK--LFWKKSVKEDS 386
E + KG G + T +G K++ G T K + KK V+ S
Sbjct: 572 EPEEITCLEKGLAEVQQDGEAEEGAT----SDGEKKREGVTPWASFKKMVTPKKRVRRPS 627
Query: 387 VPTGAEENVVCESPVEIIKSKEVESALQTVDLNEGDAAPEPTEAKLKREESKPRTSLM-- 444
+E +S + S E ++ ++ P+P E K K + S +L+
Sbjct: 628 ESDKEDELDKVKSAT--LSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICV 685
Query: 445 -----------AFLRQMSVKGDGGITHSEEINGKDSSCQT------SDSTEKTITPPEPE 487
+ + K GG + GKD T S + PE
Sbjct: 686 GSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPE 745
Query: 488 PTGAPQKGKEGSSKD--KKSAAEMNKQKSNKQEAKEPA---QCTEQATVDTNSLQNGDKL 542
G+P +G+ S+ + K+ K KS +E E + E +T DT
Sbjct: 746 QAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDT--------- 796
Query: 543 QKRPEKRQQSLGGFFKGLGPKRMLDAQVQTDPVSIGPVGKSK 584
+ E+ S+ F G KR Q Q GP G ++
Sbjct: 797 EPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANE 838
Score = 31.6 bits (70), Expect = 2.1
Identities = 64/289 (22%), Positives = 105/289 (36%), Gaps = 47/289 (16%)
Query: 297 PNKAETKKDPEDTG----AEKSPTTSAD---LKSDKANFTSQET---------------- 333
P + T +PE +G AE +P T+AD SD A Q+
Sbjct: 16 PEGSSTPAEPEPSGGGPSAEAAPDTTADPAIAASDPATKLLQKNGQLSTINGVAEQDELS 75
Query: 334 --------QGAGKNSKGCNPSGHTQSVTTPEPAKEGTKEKSGPTSLPLGKLFWKKSVKED 385
Q N +G S + V E + +++ S S ++ K +V D
Sbjct: 76 LQEGDLNGQKGALNGQGALNSQEEEEVIVTEVGQRDSEDVSKRDSDK--EMATKSAVVHD 133
Query: 386 SVPTGAEENVVCESPVEIIKSKE--VESALQTVDLNEGDAAPEPTE--AKLKREESKPRT 441
G EE +E I S E +E Q + D + K K +T
Sbjct: 134 ITDDGQEET---PEIIEQIPSSESNLEELTQPTESQANDIGFKKVFKFVGFKFTVKKDKT 190
Query: 442 SLMAFLRQMSVKGDGGITHSEEINGKDSSCQTSDSTEKTITPPE----PEPTGAPQKGKE 497
++ ++VK D G + + KD S ++ K P + PE T ++
Sbjct: 191 EKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGAGEAASKESEPKQSTEKPEETLKREQSHA 250
Query: 498 GSSKDKKS--AAEMNKQKSNKQEAKEPAQCTEQATVDTNSLQNGDKLQK 544
S +S A E K++ +++ KEP++ E T S + G +K
Sbjct: 251 EISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTS-ETGSTFKK 298
>gi|21493024 A kinase (PRKA) anchor protein 12 isoform 2 [Homo
sapiens]
Length = 1684
Score = 43.9 bits (102), Expect = 4e-04
Identities = 108/522 (20%), Positives = 186/522 (35%), Gaps = 81/522 (15%)
Query: 129 PANKDPSESWTLPVAAGPGQDTDKTPGHAPAQ---DKVLSAARDPTLLPPETGGAGGEAP 185
P D E VA+ +++ PA+ + LSA + LP E +G + P
Sbjct: 234 PEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGP 293
Query: 186 SKPKDSSFFDKFF--KLDKGQEKVPGD---SQQEAKRAEHQDKVDEVPG---------LS 231
S+ K + + F K++ QE+V + S E + E + +V+E G +
Sbjct: 294 SEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMD 353
Query: 232 GQSDDVPAGKDIVDGKE--------KEGQELGTADCSVPGDPEGL--ETAKDDSQAAAIA 281
+ + K++V KE +G +L + + PEG+ E SQ
Sbjct: 354 AEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKV 413
Query: 282 ENNNSIMSFFKTLVSPNKAETKKDPEDTGAEK----------SPTTSADLKSDKANFTSQ 331
+ + F T + + +K G E+ SP + + K + + + +
Sbjct: 414 QGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPE 473
Query: 332 ETQGAGKNSKG---CNPSGHTQSVTTPEPAKEGTKEKSGPTSLPLGK--LFWKKSVKEDS 386
E + KG G + T +G K++ G T K + KK V+ S
Sbjct: 474 EPEEITCLEKGLAEVQQDGEAEEGAT----SDGEKKREGVTPWASFKKMVTPKKRVRRPS 529
Query: 387 VPTGAEENVVCESPVEIIKSKEVESALQTVDLNEGDAAPEPTEAKLKREESKPRTSLM-- 444
+E +S + S E ++ ++ P+P E K K + S +L+
Sbjct: 530 ESDKEDELDKVKSAT--LSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICV 587
Query: 445 -----------AFLRQMSVKGDGGITHSEEINGKDSSCQT------SDSTEKTITPPEPE 487
+ + K GG + GKD T S + PE
Sbjct: 588 GSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPE 647
Query: 488 PTGAPQKGKEGSSKD--KKSAAEMNKQKSNKQEAKEPA---QCTEQATVDTNSLQNGDKL 542
G+P +G+ S+ + K+ K KS +E E + E +T DT
Sbjct: 648 QAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDT--------- 698
Query: 543 QKRPEKRQQSLGGFFKGLGPKRMLDAQVQTDPVSIGPVGKSK 584
+ E+ S+ F G KR Q Q GP G ++
Sbjct: 699 EPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANE 740
>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
[Homo sapiens]
Length = 958
Score = 43.5 bits (101), Expect = 5e-04
Identities = 109/515 (21%), Positives = 191/515 (37%), Gaps = 57/515 (11%)
Query: 56 TDNVATSSPETTEISAV--ADANGKNLGKEAKPEAPAAKSRFFLMLSRPVPGRTGDQAAD 113
++ + S ET A+ A A+GK + APA +S P PG+TG A
Sbjct: 343 SEESSDSEEETPAAKALLQAKASGKT-SQVGAASAPAKESPRKGAAPAP-PGKTGPAVAK 400
Query: 114 SSLGSVKLDVSSNKAPANKDPSESWTLPVAAGP-GQDTDKTPGHAPAQDKVLSAARDPTL 172
+ G + D S+ ++ + P A P G+ APA++ A
Sbjct: 401 AQAGKREEDSQSSSEESDSEEEA----PAQAKPSGKAPQVRAASAPAKESPRKGAAPAP- 455
Query: 173 LPPETGGAGGEAPSKPKDSSFFDKFFKLDKGQEKVPGDSQQEAKRAEHQDKVDEVPG--- 229
P +TG A + ++ + D +E + + + K +V
Sbjct: 456 -PRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGM 514
Query: 230 --LSGQSDDVPAGK------DIVDGKEKEGQELGTADCSVPGDPEGLETAKDDSQAAAIA 281
L + VP GK GK +E E + + S D E + TA +Q ++
Sbjct: 515 GPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGE-VPTAVAPAQEKSLG 573
Query: 282 ENNNSIMSFFKTLVSPNKA-------ETKKDPEDTGAEKSPTTSADLKSDKANFTSQETQ 334
+ + P KA + +K +++ + + + SAD + A T+ + +
Sbjct: 574 NILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAK 633
Query: 335 GAGK--NSKGCNPSGHTQSVTTPEPAKEGTK--EKSGPTSLPLGKLFWKKSVKEDSVPTG 390
A K +K C +T + P + GT+ K+G + P G +V G
Sbjct: 634 PALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGS--------SPAVAGG 685
Query: 391 AEENVVCESPVEIIKSKEVESAL-----QTVDLNEG---DAAPEPTEAKLKREESK--PR 440
+ S E S+E ++ L Q + +G AA P + L + + P
Sbjct: 686 TQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPG 745
Query: 441 TSLMAFLRQMSVKGDGGITHSEEINGKD---SSCQTSDSTEKTITPPEPEPTGAPQ-KGK 496
+ + + K + + EE + ++ S Q S +KT P AP KG
Sbjct: 746 KTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGT 805
Query: 497 EGSSKDKKSAAEMNKQKSNKQEAKEPAQCTEQATV 531
+ +AA KQ+S + K P + + +TV
Sbjct: 806 ISAPGKVVTAAAQAKQRS-PSKVKPPVRNPQNSTV 839
>gi|225543215 antigen identified by monoclonal antibody Ki-67 isoform
2 [Homo sapiens]
Length = 2896
Score = 43.1 bits (100), Expect = 7e-04
Identities = 98/436 (22%), Positives = 163/436 (37%), Gaps = 74/436 (16%)
Query: 120 KLDVSSNKAPANKDPS----ESWTLPVAAGPGQDTDKTPGHAPAQDKVLSAARDPTLLPP 175
KLD++ N + + P E+ L G ++ +TPGH + AA T +P
Sbjct: 959 KLDLTENLTGSKRRPQTPKEEAQALEDLTG-FKELFQTPGHT----EEAVAAGKTTKMPC 1013
Query: 176 ETGGAGGEAPSKPKDSSFFDKFFKLDKGQEKVPGDSQQEAKRAEHQDKVDEVPGLSGQSD 235
E+ E+ P + + Q K P + + K K+ + G + +D
Sbjct: 1014 ESSPP--ESADTPTST----------RRQPKTPLEKRDVQKELSALKKLTQTSGETTHTD 1061
Query: 236 DVPAGKD--IVDGKEKEGQELGTADCSVPGDPEGLETAKDDSQAAAIAENNNSIMSFFKT 293
VP G+D I +E Q+L A SV G +T + A E+ + F+T
Sbjct: 1062 KVPGGEDKSINAFRETAKQKLDPA-ASVTGSKRHPKT----KEKAQPLEDLAGLKELFQT 1116
Query: 294 LVSPNKAET-----------KKDPEDTGAEKSPTTSADLK----SDKANFTSQETQGAGK 338
V +K T + DP DT P + L+ ++ + T AGK
Sbjct: 1117 PVCTDKPTTHEKTTKIACRSQPDPVDTPTSSKPQSKRSLRKVDVEEEFFALRKRTPSAGK 1176
Query: 339 NSKGCNPSGHTQSVTTPEPAKEGTKEKSGPTSLPLGKLFWKKSVKEDSVPTGAEENVVCE 398
++ TP+PA G K P+ KL +++ TG++ + +
Sbjct: 1177 ------------AMHTPKPAVSGEKNIYAFMGTPVQKLDLTENL------TGSKRRL--Q 1216
Query: 399 SPVEIIKSKEVESALQTVDLNEGDAAPEPTE---AKLKREESKPRTSLMAFLRQMSVKGD 455
+P E ++ E + + + G T AK+ + S+P + +K
Sbjct: 1217 TPKEKAQALEDLAGFKELFQTRGHTEESMTNDKTAKVACKSSQPDPDKNPASSKRRLKTS 1276
Query: 456 -GGITHSEEINGKDSSCQTSDSTEKTITPPEPEPTGAPQKGKEGSSKDKK---SAAEMNK 511
G + EE+ QTS T T T EPTG + K K+ SAA +
Sbjct: 1277 LGKVGVKEELLAVGKLTQTSGETTHTHT----EPTGDGKSMKAFMESPKQILDSAASLTG 1332
Query: 512 QKSNKQEAKEPAQCTE 527
K + K ++ E
Sbjct: 1333 SKRQLRTPKGKSEVPE 1348
Score = 32.0 bits (71), Expect = 1.6
Identities = 52/247 (21%), Positives = 96/247 (38%), Gaps = 24/247 (9%)
Query: 296 SPNKAETKKDPEDTGAEKSPTTSADLKSDKANFTSQETQGAGKNSKG-CNPSGHTQSVTT 354
SP K K P D+K + S+ T+ +G+ ++ P+G ++S+
Sbjct: 2106 SPQPESFKTSRSSKQRLKIPLVKVDMKEEPLA-VSKLTRTSGETTQTHTEPTGDSKSI-- 2162
Query: 355 PEPAKEGTKEKSGPTSLPLGKLFWKKSVKEDSVPTGAEENVV-----------CESPVEI 403
+ KE K+ P + G ++ KE + A E++V E + I
Sbjct: 2163 -KAFKESPKQILDPAASVTGSRRQLRTRKEKA---RALEDLVDFKELFSAPGHTEESMTI 2218
Query: 404 IKSKEVESALQTVDLNEGDAAPEPTEAKLKREESKPRTSLMAFLRQMSVKGDGGITHSEE 463
K+ ++ +L + + + R+E K S + L Q S G TH E
Sbjct: 2219 DKNTKIPCKSPPPELTDTATSTKRCPKTRPRKEVKEELSAVERLTQTS--GQSTHTHKEP 2276
Query: 464 INGKDSSCQTSDSTEKTITPPEPEPT-GAPQKGKEGSS--KDKKSAAEMNKQKSNKQEAK 520
+G + +K P E EP+ P+ KE + +D E+++ + QE+
Sbjct: 2277 ASGDEGIKVLKQRAKKKPNPVEEEPSRRRPRAPKEKAQPLEDLAGFTELSETSGHTQESL 2336
Query: 521 EPAQCTE 527
+ T+
Sbjct: 2337 TAGKATK 2343
>gi|103472005 antigen identified by monoclonal antibody Ki-67 isoform
1 [Homo sapiens]
Length = 3256
Score = 43.1 bits (100), Expect = 7e-04
Identities = 98/436 (22%), Positives = 163/436 (37%), Gaps = 74/436 (16%)
Query: 120 KLDVSSNKAPANKDPS----ESWTLPVAAGPGQDTDKTPGHAPAQDKVLSAARDPTLLPP 175
KLD++ N + + P E+ L G ++ +TPGH + AA T +P
Sbjct: 1319 KLDLTENLTGSKRRPQTPKEEAQALEDLTG-FKELFQTPGHT----EEAVAAGKTTKMPC 1373
Query: 176 ETGGAGGEAPSKPKDSSFFDKFFKLDKGQEKVPGDSQQEAKRAEHQDKVDEVPGLSGQSD 235
E+ E+ P + + Q K P + + K K+ + G + +D
Sbjct: 1374 ESSPP--ESADTPTST----------RRQPKTPLEKRDVQKELSALKKLTQTSGETTHTD 1421
Query: 236 DVPAGKD--IVDGKEKEGQELGTADCSVPGDPEGLETAKDDSQAAAIAENNNSIMSFFKT 293
VP G+D I +E Q+L A SV G +T + A E+ + F+T
Sbjct: 1422 KVPGGEDKSINAFRETAKQKLDPA-ASVTGSKRHPKT----KEKAQPLEDLAGLKELFQT 1476
Query: 294 LVSPNKAET-----------KKDPEDTGAEKSPTTSADLK----SDKANFTSQETQGAGK 338
V +K T + DP DT P + L+ ++ + T AGK
Sbjct: 1477 PVCTDKPTTHEKTTKIACRSQPDPVDTPTSSKPQSKRSLRKVDVEEEFFALRKRTPSAGK 1536
Query: 339 NSKGCNPSGHTQSVTTPEPAKEGTKEKSGPTSLPLGKLFWKKSVKEDSVPTGAEENVVCE 398
++ TP+PA G K P+ KL +++ TG++ + +
Sbjct: 1537 ------------AMHTPKPAVSGEKNIYAFMGTPVQKLDLTENL------TGSKRRL--Q 1576
Query: 399 SPVEIIKSKEVESALQTVDLNEGDAAPEPTE---AKLKREESKPRTSLMAFLRQMSVKGD 455
+P E ++ E + + + G T AK+ + S+P + +K
Sbjct: 1577 TPKEKAQALEDLAGFKELFQTRGHTEESMTNDKTAKVACKSSQPDPDKNPASSKRRLKTS 1636
Query: 456 -GGITHSEEINGKDSSCQTSDSTEKTITPPEPEPTGAPQKGKEGSSKDKK---SAAEMNK 511
G + EE+ QTS T T T EPTG + K K+ SAA +
Sbjct: 1637 LGKVGVKEELLAVGKLTQTSGETTHTHT----EPTGDGKSMKAFMESPKQILDSAASLTG 1692
Query: 512 QKSNKQEAKEPAQCTE 527
K + K ++ E
Sbjct: 1693 SKRQLRTPKGKSEVPE 1708
Score = 32.0 bits (71), Expect = 1.6
Identities = 52/247 (21%), Positives = 96/247 (38%), Gaps = 24/247 (9%)
Query: 296 SPNKAETKKDPEDTGAEKSPTTSADLKSDKANFTSQETQGAGKNSKG-CNPSGHTQSVTT 354
SP K K P D+K + S+ T+ +G+ ++ P+G ++S+
Sbjct: 2466 SPQPESFKTSRSSKQRLKIPLVKVDMKEEPLA-VSKLTRTSGETTQTHTEPTGDSKSI-- 2522
Query: 355 PEPAKEGTKEKSGPTSLPLGKLFWKKSVKEDSVPTGAEENVV-----------CESPVEI 403
+ KE K+ P + G ++ KE + A E++V E + I
Sbjct: 2523 -KAFKESPKQILDPAASVTGSRRQLRTRKEKA---RALEDLVDFKELFSAPGHTEESMTI 2578
Query: 404 IKSKEVESALQTVDLNEGDAAPEPTEAKLKREESKPRTSLMAFLRQMSVKGDGGITHSEE 463
K+ ++ +L + + + R+E K S + L Q S G TH E
Sbjct: 2579 DKNTKIPCKSPPPELTDTATSTKRCPKTRPRKEVKEELSAVERLTQTS--GQSTHTHKEP 2636
Query: 464 INGKDSSCQTSDSTEKTITPPEPEPT-GAPQKGKEGSS--KDKKSAAEMNKQKSNKQEAK 520
+G + +K P E EP+ P+ KE + +D E+++ + QE+
Sbjct: 2637 ASGDEGIKVLKQRAKKKPNPVEEEPSRRRPRAPKEKAQPLEDLAGFTELSETSGHTQESL 2696
Query: 521 EPAQCTE 527
+ T+
Sbjct: 2697 TAGKATK 2703
>gi|169658378 trinucleotide repeat containing 18 [Homo sapiens]
Length = 2968
Score = 43.1 bits (100), Expect = 7e-04
Identities = 54/266 (20%), Positives = 97/266 (36%), Gaps = 15/266 (5%)
Query: 104 PGRTGDQAADSSLGSVKLDVSSNKAPANKDPSESWTLPVAAGPGQDTDKTPGHAPAQDKV 163
P R G++A VKLD +P +K E+ L + PG + P +
Sbjct: 2451 PRRPGEEAELL----VKLDHEGVTSPKSKKAKEA--LLLREDPGAGGWQEPKSLLSLGSY 2504
Query: 164 LSAARDPTLLPPETGGAGGEAPSKPKDSSFFDKFFKLDKGQEKVPGDSQQEAKRAEHQDK 223
AA P G+ +P F+ D G K P +Q E AE +
Sbjct: 2505 PPAAGSSEPKAPWPKATDGDLAQEPGPGLTFE-----DSGNPKSPDKAQAEQDGAEESES 2559
Query: 224 VDEVPGLSGQSDDVPAGKDIVDGKEKEGQELGTADCSVPGDPEGLETAKDDSQAAAIAEN 283
S S + G E EG+E G + G + S+AA+ A +
Sbjct: 2560 SSSSSSGSSSSSSSSSSS----GSETEGEEEGDKNGDGGCGTGGRNCSAASSRAASPASS 2615
Query: 284 NNSIMSFFKTLVSPNKAETKKDPEDTGAEKSPTTSADLKSDKANFTSQETQGAGKNSKGC 343
++S S + S + + + + + S ++S+ S ++ +S + + ++
Sbjct: 2616 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDE 2675
Query: 344 NPSGHTQSVTTPEPAKEGTKEKSGPT 369
+ S + P P + + + PT
Sbjct: 2676 DSSCSSDDEAAPAPTAGPSAQAALPT 2701
Score = 40.0 bits (92), Expect = 0.006
Identities = 50/244 (20%), Positives = 82/244 (33%), Gaps = 26/244 (10%)
Query: 307 EDTGAEKSPTTSADLKSDKANFTSQETQGAGKNSKGCNPSGHTQSVTTPEPAKEGTKEKS 366
ED+G KSP A + D A +E++ + +S G + S + S + E E +K+
Sbjct: 2536 EDSGNPKSPD-KAQAEQDGA----EESESSSSSSSGSSSSSSSSSSSGSETEGEEEGDKN 2590
Query: 367 GPTSLPLGKLFWKKSVKEDSVPTGAEENVVCESPVEIIKSKEVESALQTVDLNEGDAAPE 426
G + TG S S S+ + + ++
Sbjct: 2591 G----------------DGGCGTGGRNCSAASSRAASPASSSSSSSSSSSSSSSSSSSSS 2634
Query: 427 PTEAKLKREESKPRTSLMAFLRQMSVKGDGGITHSEEINGKDSSCQTSDSTEKTITPPEP 486
+ + S +S + S + S +DSSC + D T
Sbjct: 2635 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDEDSSCSSDDEAAPAPTAGPS 2694
Query: 487 EPTGAPQKGKEGSSKDKKSAAEMNKQKSNKQEAKEPAQCTEQATVDTNSLQNGDKLQKRP 546
P K + + K + SA K+ Q P Q T+ Q G K RP
Sbjct: 2695 AQAALPTKATKQAGKARPSAHSPGKKTPAPQPQAPPPQPTQPL---QPKAQAGAK--SRP 2749
Query: 547 EKRQ 550
+KR+
Sbjct: 2750 KKRE 2753
>gi|55741677 SET domain containing 1A [Homo sapiens]
Length = 1707
Score = 42.7 bits (99), Expect = 0.001
Identities = 40/192 (20%), Positives = 81/192 (42%), Gaps = 16/192 (8%)
Query: 132 KDPSESWTLPVAAGPGQDTDKTPGHA----PAQDKVLSAARDPTLLPPETGGAGGEAPSK 187
K+PSE + A+ + TP P Q+K P PP+ G+ K
Sbjct: 898 KEPSE---ISEASEEKRPRPSTPAEEDEDDPEQEKEAGEPGRPGTKPPKRDEERGKTQGK 954
Query: 188 PKDSSFFDKFFKLDKGQEKVPGDSQQEAKRAEHQDKVDEVPGLSGQSDDVPAGKDIVDGK 247
+ S D +G+E S ++ + + +D+ DE D ++ DG+
Sbjct: 955 HRKSFALDS-----EGEEASQESSSEKDEEDDEEDEEDE--DREEAVDTTKKETEVSDGE 1007
Query: 248 EKEGQELGTADCSVPGDPEGLETAKDDSQAAAIAENNNSIMSFFKTLVSPNKAETKKDPE 307
++E ++ CS+ D +G + DS++++ + +++S S + S + +E+ + E
Sbjct: 1008 DEESDS--SSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDE 1065
Query: 308 DTGAEKSPTTSA 319
+ + SA
Sbjct: 1066 EEEERPAALPSA 1077
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 42.7 bits (99), Expect = 0.001
Identities = 53/261 (20%), Positives = 95/261 (36%), Gaps = 41/261 (15%)
Query: 300 AETKKDPEDTGAEKSPTTSADLKSDKANFTSQETQGAGKNSKGCNPSGHTQSVTTPEPAK 359
++ + P TGA++ P+ A L+ K E + + +S + S + S ++ +
Sbjct: 2504 SDVGEPPASTGAQQ-PSALAALQPAK------ERRSSSSSSSSSSSSSSSSSSSSSSSSS 2556
Query: 360 EGTKEKSGPTSLPLGKLFWKKSVKEDSVPTGAEENVVCESPVEIIKSKEVESALQTVDLN 419
+ S +SLP+ + ++K PT A + V E
Sbjct: 2557 GSSSSDSEGSSLPVQP---EVALKRVPSPTPAPKEAVREG-------------------- 2593
Query: 420 EGDAAPEPTEAKLKREESKPRTSLMAFLRQMSVKGDGGITHSEEINGKDSSCQTSDSTEK 479
PEPT AK KR S +S + S + S + SS +S S+
Sbjct: 2594 ---RPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPS 2650
Query: 480 TITP-----PEPEPTGAPQKGKEGSSKDKKSAAEMNKQKS---NKQEAKEPAQCTEQATV 531
P P+P P G+ S +K + +S + E + P+
Sbjct: 2651 PAKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPVERRRPSPQPSPRDQ 2710
Query: 532 DTNSLQNGDKLQKRPEKRQQS 552
++S + G + +R + R S
Sbjct: 2711 QSSSSERGSRRGQRGDSRSPS 2731
Score = 38.9 bits (89), Expect = 0.013
Identities = 57/283 (20%), Positives = 101/283 (35%), Gaps = 46/283 (16%)
Query: 123 VSSNKAPANKDPSESWTLPVAAGPGQDTDKTPGHAPAQDKVLSAARDPTLLPPETGGAGG 182
VS +P D + S T P A + T + AP+ + A +LLPP
Sbjct: 2393 VSGRTSPPLLDRARSRTPPSAPSQSRMTSE---RAPSPSSRMGQAPSQSLLPPAQ----- 2444
Query: 183 EAPSKPKDSSFFDKFFKLDKGQEKVPGDSQQE---------------------AKRAEHQ 221
+ P P S+F D+ L V G A H
Sbjct: 2445 DQPRSPVPSAFSDQSRCLIAQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHS 2504
Query: 222 DKVDEVPGLSGQSDDVPAGKDIVDGKEKEGQELGTADCSVPGDPEGLETAKDDSQAAAIA 281
D V E P +G P+ + ++ ++ S ++ S ++ +
Sbjct: 2505 D-VGEPPASTGAQQ--PSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSS 2561
Query: 282 ENNNSIMSF-----FKTLVSPNKAETK-----KDPEDTGAEK----SPTTSADLKSDKAN 327
++ S + K + SP A + + PE T A++ S ++S+ S ++
Sbjct: 2562 DSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSS 2621
Query: 328 FTSQETQGAGKNSKGCNPSGHTQSVTTPEPAKEGTKEKSGPTS 370
+S + + +S + S + S ++P PAK G + P S
Sbjct: 2622 SSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPAS 2664
Score = 36.6 bits (83), Expect = 0.066
Identities = 61/280 (21%), Positives = 104/280 (37%), Gaps = 36/280 (12%)
Query: 301 ETKKDPEDTGAEKSPTTSADLKSDKAN-FTSQETQGAGKNSKGCNPSGHTQSVTT----- 354
++K+ +D ++S +T+ KS +A+ TS ++ + S+ + S ++ TT
Sbjct: 235 KSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALAGR 294
Query: 355 -PEPAKEGTKEKSGPTSLPLGKLFWKKSVKEDSVPTGAEENVVCESPVEII-KSKEVESA 412
P PA E P S P S + S P A + SP E K K+ +SA
Sbjct: 295 SPSPASGRRGEGDAPFSEP-----GTTSTQRPSSPETATKQP--SSPYEDKDKDKKEKSA 347
Query: 413 LQTVDLNE----GDAAPEPTEAKLKREESKPRTSLMAFLRQMSVKGDGGITHSEEINGKD 468
+ E G P PT +R P+ L Q V + + + +
Sbjct: 348 TRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPPSEASPTRDRSPPK 407
Query: 469 SSCQTSDSTEKTITPPEPEPT----------------GAPQKGKEGSSKDKKSAAEMNKQ 512
S + S+ +PP P+PT AP +E SS +
Sbjct: 408 SPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREISSSPTSKNRSHGRA 467
Query: 513 KSNKQEAKEPAQCTEQATVDTNSLQNGDKLQKRPEKRQQS 552
K +K + P++ ++ + + G + P KR S
Sbjct: 468 KRDKSHSHTPSRRMGRSRSPATA-KRGRSRSRTPTKRGHS 506
Score = 32.0 bits (71), Expect = 1.6
Identities = 18/106 (16%), Positives = 45/106 (42%), Gaps = 4/106 (3%)
Query: 483 PPEPEPTGAPQKGKEGSSKDKKSAAEMNKQKSNKQEAKEPAQCTEQATVDTNSLQN---- 538
PPEP P ++ SS S++ + S+ + + + ++ ++S +
Sbjct: 2595 PPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKP 2654
Query: 539 GDKLQKRPEKRQQSLGGFFKGLGPKRMLDAQVQTDPVSIGPVGKSK 584
G + +P ++ G + P++ +D+ + +S PV + +
Sbjct: 2655 GPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPVERRR 2700
>gi|4503257 death-domain associated protein isoform a [Homo sapiens]
Length = 740
Score = 42.4 bits (98), Expect = 0.001
Identities = 83/404 (20%), Positives = 153/404 (37%), Gaps = 55/404 (13%)
Query: 7 VPQRVEDQENEPEAETYQDNASALNGVPVVVSTHTV-QHLEEVDLGISVKTDNVATSSPE 65
V +R+E N+P +T+ D L V + H++ +++ L +V E
Sbjct: 267 VNRRIERLINKPGPDTFPDYGDVLRAVEKAAARHSLGLPRQQLQLMAQDAFRDVGIRLQE 326
Query: 66 TTEISAVADANGKNLGKEAKPEAPAAKSRFFLMLSRPVPGRTGDQAADSSLGSVKLDVSS 125
+ + + G +L + +P A LS PV R + SL +LD
Sbjct: 327 RRHLDLIYNF-GCHLTDDYRPGVDPA-------LSDPVLARR--LRENRSLAMSRLDEVI 376
Query: 126 NKAPANKDPSESWTLPVAAGPGQDTDKTPGHAPAQDKVLSAARDPTLLPPETGGAGGEAP 185
+K +D SE Q T P + L + P +G A P
Sbjct: 377 SKYAMLQDKSEEGERKKRRARLQGTSSHSADTP--EASLDSGEGP------SGMASQGCP 428
Query: 186 SKPKDSSFFDKFFKLDKGQEKVPGDSQQEAKRAEHQDKVDEVPGLSGQSDDVPAGKDIVD 245
S + + + + D+ +E+ + ++EA +E ++ ++++ GQ DD ++
Sbjct: 429 SASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQ--EGQEDDEEEDEEEEA 486
Query: 246 GKEKEGQELGTADCSVPGDPEGLETAKDDSQAAAIAENNNSIMS---FFKTLVSPNKAET 302
K+G + + + + + LE K S+++ +N I+S + ++P+ +
Sbjct: 487 AAGKDGDKSPMSSLQISNE-KNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDA 545
Query: 303 KKDPED----TGAEKSPTT----------------------SADLKSDKANFTSQETQGA 336
+ + E T E+SP + S+ K + FT+ GA
Sbjct: 546 ESNGEQPEELTLEEESPVSQLFELEIEALPLDTPSSVETDISSSRKQSEEPFTTVLENGA 605
Query: 337 G---KNSKGCNPSGHTQSVTTPEPAKEGTKEKSGPTSLPLGKLF 377
G S S H + P P K+ KEK S PLG +
Sbjct: 606 GMVSSTSFNGGVSPHNWGDSGP-PCKKSRKEKKQTGSGPLGNSY 648
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.302 0.122 0.337
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,573,831
Number of Sequences: 37866
Number of extensions: 1436557
Number of successful extensions: 5942
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 47
Number of HSP's successfully gapped in prelim test: 383
Number of HSP's that attempted gapping in prelim test: 5240
Number of HSP's gapped (non-prelim): 986
length of query: 584
length of database: 18,247,518
effective HSP length: 108
effective length of query: 476
effective length of database: 14,157,990
effective search space: 6739203240
effective search space used: 6739203240
T: 11
A: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.