Guide to the Human Genome
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Search of human proteins with 189491771

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|189491771 thyroid hormone receptor, beta [Homo sapiens]
         (461 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|189491771 thyroid hormone receptor, beta [Homo sapiens]            959   0.0  
gi|189491769 thyroid hormone receptor, beta [Homo sapiens]            959   0.0  
gi|40806162 thyroid hormone receptor, beta [Homo sapiens]             959   0.0  
gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo sapi...   654   0.0  
gi|20127452 thyroid hormone receptor, alpha isoform 2 [Homo sapi...   577   e-165
gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens]   238   7e-63
gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens]     238   7e-63
gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens]     237   1e-62
gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens]    234   9e-62
gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens]   231   8e-61
gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens]     231   1e-60
gi|194294519 nuclear receptor subfamily 1, group H, member 3 iso...   209   6e-54
gi|194294517 nuclear receptor subfamily 1, group H, member 3 iso...   209   6e-54
gi|85362735 nuclear receptor subfamily 1, group H, member 2 [Hom...   194   2e-49
gi|7706625 retinoic acid receptor, beta isoform 2 [Homo sapiens]      189   6e-48
gi|4826980 nuclear receptor subfamily 1, group H, member 4 [Homo...   173   3e-43
gi|14702164 nuclear receptor subfamily 1, group I, member 2 isof...   172   6e-43
gi|4826661 constitutive androstane receptor isoform 3 [Homo sapi...   169   4e-42
gi|117938752 constitutive androstane receptor isoform 2 [Homo sa...   166   3e-41
gi|117938756 constitutive androstane receptor isoform 1 [Homo sa...   161   1e-39
gi|63054845 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo ...   160   2e-39
gi|4507883 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo s...   160   2e-39
gi|117938746 constitutive androstane receptor isoform 7 [Homo sa...   159   4e-39
gi|117938729 constitutive androstane receptor isoform 6 [Homo sa...   157   2e-38
gi|5453940 peroxisome proliferative activated receptor, delta is...   152   6e-37
gi|223718070 retinoic acid receptor, alpha isoform 4 [Homo sapiens]   150   2e-36
gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo...   150   2e-36
gi|4506755 retinoid X receptor, alpha [Homo sapiens]                  148   9e-36
gi|117938754 constitutive androstane receptor isoform 4 [Homo sa...   145   8e-35
gi|117938734 constitutive androstane receptor isoform 5 [Homo sa...   145   8e-35

>gi|189491771 thyroid hormone receptor, beta [Homo sapiens]
          Length = 461

 Score =  959 bits (2479), Expect = 0.0
 Identities = 461/461 (100%), Positives = 461/461 (100%)

Query: 1   MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQ 60
           MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQ
Sbjct: 1   MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQ 60

Query: 61  TTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR 120
           TTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR
Sbjct: 61  TTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR 120

Query: 121 CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL 180
           CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL
Sbjct: 121 CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL 180

Query: 181 DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK 240
           DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK
Sbjct: 181 DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK 240

Query: 241 QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED 300
           QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED
Sbjct: 241 QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED 300

Query: 301 QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL 360
           QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL
Sbjct: 301 QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL 360

Query: 361 SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK 420
           SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK
Sbjct: 361 SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK 420

Query: 421 LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED 461
           LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
Sbjct: 421 LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED 461


>gi|189491769 thyroid hormone receptor, beta [Homo sapiens]
          Length = 461

 Score =  959 bits (2479), Expect = 0.0
 Identities = 461/461 (100%), Positives = 461/461 (100%)

Query: 1   MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQ 60
           MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQ
Sbjct: 1   MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQ 60

Query: 61  TTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR 120
           TTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR
Sbjct: 61  TTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR 120

Query: 121 CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL 180
           CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL
Sbjct: 121 CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL 180

Query: 181 DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK 240
           DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK
Sbjct: 181 DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK 240

Query: 241 QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED 300
           QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED
Sbjct: 241 QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED 300

Query: 301 QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL 360
           QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL
Sbjct: 301 QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL 360

Query: 361 SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK 420
           SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK
Sbjct: 361 SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK 420

Query: 421 LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED 461
           LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
Sbjct: 421 LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED 461


>gi|40806162 thyroid hormone receptor, beta [Homo sapiens]
          Length = 461

 Score =  959 bits (2479), Expect = 0.0
 Identities = 461/461 (100%), Positives = 461/461 (100%)

Query: 1   MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQ 60
           MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQ
Sbjct: 1   MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQ 60

Query: 61  TTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR 120
           TTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR
Sbjct: 61  TTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR 120

Query: 121 CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL 180
           CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL
Sbjct: 121 CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL 180

Query: 181 DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK 240
           DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK
Sbjct: 181 DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK 240

Query: 241 QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED 300
           QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED
Sbjct: 241 QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED 300

Query: 301 QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL 360
           QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL
Sbjct: 301 QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL 360

Query: 361 SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK 420
           SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK
Sbjct: 361 SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK 420

Query: 421 LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED 461
           LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
Sbjct: 421 LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED 461


>gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo
           sapiens]
          Length = 410

 Score =  654 bits (1686), Expect = 0.0
 Identities = 310/367 (84%), Positives = 342/367 (93%)

Query: 95  GYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVID 154
           GYIPSYLDKDE CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHP+YSCKY+  CVID
Sbjct: 41  GYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVID 100

Query: 155 KVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEP 214
           K+TRNQCQ CRFKKCI VGMA DLVLDDSKR+AKRKLIE+NRE+RR+EE+ +S+  +PEP
Sbjct: 101 KITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEP 160

Query: 215 TDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTK 274
           T EEW+LI   TEAH +TNAQGSHWKQ+RKFLP+DIGQ+PIV+ P+G KVDLEAFS FTK
Sbjct: 161 TPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTK 220

Query: 275 IITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEM 334
           IITPAITRVVDFAKKLPMF ELPCEDQIILLKGCCMEIMSLRAAVRYDPES+TLTL+GEM
Sbjct: 221 IITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEM 280

Query: 335 AVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEK 394
           AV R QLKNGGLGVVSDAIF+LG SLS+FNLDDTEVALLQAVLLMS+DR GL CV++IEK
Sbjct: 281 AVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEK 340

Query: 395 YQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPL 454
            Q+++LLAFEHY+N+RKH++ HFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPL
Sbjct: 341 SQEAYLLAFEHYVNHRKHNIPHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPL 400

Query: 455 FLEVFED 461
           FLEVFED
Sbjct: 401 FLEVFED 407


>gi|20127452 thyroid hormone receptor, alpha isoform 2 [Homo
           sapiens]
          Length = 490

 Score =  577 bits (1487), Expect = e-165
 Identities = 273/335 (81%), Positives = 308/335 (91%)

Query: 95  GYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVID 154
           GYIPSYLDKDE CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHP+YSCKY+  CVID
Sbjct: 41  GYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVID 100

Query: 155 KVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEP 214
           K+TRNQCQ CRFKKCI VGMA DLVLDDSKR+AKRKLIE+NRE+RR+EE+ +S+  +PEP
Sbjct: 101 KITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEP 160

Query: 215 TDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTK 274
           T EEW+LI   TEAH +TNAQGSHWKQ+RKFLP+DIGQ+PIV+ P+G KVDLEAFS FTK
Sbjct: 161 TPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTK 220

Query: 275 IITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEM 334
           IITPAITRVVDFAKKLPMF ELPCEDQIILLKGCCMEIMSLRAAVRYDPES+TLTL+GEM
Sbjct: 221 IITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEM 280

Query: 335 AVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEK 394
           AV R QLKNGGLGVVSDAIF+LG SLS+FNLDDTEVALLQAVLLMS+DR GL CV++IEK
Sbjct: 281 AVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEK 340

Query: 395 YQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLR 429
            Q+++LLAFEHY+N+RKH++ HFWPKLLMK  +++
Sbjct: 341 SQEAYLLAFEHYVNHRKHNIPHFWPKLLMKEREVQ 375


>gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
          Length = 462

 Score =  238 bits (608), Expect = 7e-63
 Identities = 139/393 (35%), Positives = 208/393 (52%), Gaps = 32/393 (8%)

Query: 75  VNDQSVSSAQTFQTEEKKCKGYIPSYLDKDEL------CVVCGDKATGYHYRCITCEGCK 128
           V+  S  S  T +T+    +  +PS      L      C VC DK++GYHY    CEGCK
Sbjct: 50  VSGYSTPSPATIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCK 109

Query: 129 GFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAK 188
           GFFRR+IQKN+   Y+C  +  C+I+KVTRN+CQ CR +KC  VGM+ + V +D      
Sbjct: 110 GFFRRSIQKNM--VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRND------ 161

Query: 189 RKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPE 248
                  R K+++E  +         T E  ELI+ V +AH  T        Q  K+   
Sbjct: 162 -------RNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALC---QLGKYTTN 211

Query: 249 DIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGC 308
           +  +  +        +D++ +  F+++ T  I + V+FAK+LP F  L   DQI LLK  
Sbjct: 212 NSSEQRV-------SLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAA 264

Query: 309 CMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDT 368
           C++I+ LR   RY PE +T+T +  + + R Q+ N G G ++D +F     L    +DD 
Sbjct: 265 CLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDA 324

Query: 369 EVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDL 428
           E  LL A+ L+  DR  L   +R++  Q+  L A + Y+  R+    H +PK+LMK+TDL
Sbjct: 325 ETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDL 384

Query: 429 RMIGACHASRFLHMKVECPTELFPPLFLEVFED 461
           R I A  A R + +K+E P  + PPL  E+ E+
Sbjct: 385 RSISAKGAERVITLKMEIPGSM-PPLIQEMLEN 416


>gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
          Length = 462

 Score =  238 bits (608), Expect = 7e-63
 Identities = 139/393 (35%), Positives = 208/393 (52%), Gaps = 32/393 (8%)

Query: 75  VNDQSVSSAQTFQTEEKKCKGYIPSYLDKDEL------CVVCGDKATGYHYRCITCEGCK 128
           V+  S  S  T +T+    +  +PS      L      C VC DK++GYHY    CEGCK
Sbjct: 50  VSGYSTPSPATIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCK 109

Query: 129 GFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAK 188
           GFFRR+IQKN+   Y+C  +  C+I+KVTRN+CQ CR +KC  VGM+ + V +D      
Sbjct: 110 GFFRRSIQKNM--VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRND------ 161

Query: 189 RKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPE 248
                  R K+++E  +         T E  ELI+ V +AH  T        Q  K+   
Sbjct: 162 -------RNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALC---QLGKYTTN 211

Query: 249 DIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGC 308
           +  +  +        +D++ +  F+++ T  I + V+FAK+LP F  L   DQI LLK  
Sbjct: 212 NSSEQRV-------SLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAA 264

Query: 309 CMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDT 368
           C++I+ LR   RY PE +T+T +  + + R Q+ N G G ++D +F     L    +DD 
Sbjct: 265 CLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDA 324

Query: 369 EVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDL 428
           E  LL A+ L+  DR  L   +R++  Q+  L A + Y+  R+    H +PK+LMK+TDL
Sbjct: 325 ETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDL 384

Query: 429 RMIGACHASRFLHMKVECPTELFPPLFLEVFED 461
           R I A  A R + +K+E P  + PPL  E+ E+
Sbjct: 385 RSISAKGAERVITLKMEIPGSM-PPLIQEMLEN 416


>gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens]
          Length = 448

 Score =  237 bits (605), Expect = 1e-62
 Identities = 139/386 (36%), Positives = 209/386 (54%), Gaps = 32/386 (8%)

Query: 82  SAQTFQTEEKKCKGYIPSYLDK------DELCVVCGDKATGYHYRCITCEGCKGFFRRTI 135
           +AQ+ +T+    +  +PS           + C VC DK++GYHY    CEGCKGFFRR+I
Sbjct: 50  TAQSIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSI 109

Query: 136 QKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEEN 195
           QKN+   Y+C  +  CVI+KVTRN+CQ CR +KC  VGM+ + V +D             
Sbjct: 110 QKNM--IYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRND------------- 154

Query: 196 REKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPI 255
           R K+++E  ++      E T E  +L + + +AH  T        Q  K+          
Sbjct: 155 RNKKKKETSKQECTESYEMTAELDDLTEKIRKAHQETFPSLC---QLGKYTTNS------ 205

Query: 256 VNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSL 315
            +A    ++DL  +  F+++ T  I ++V+FAK+LP F  L   DQI LLK  C++I+ L
Sbjct: 206 -SADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILIL 264

Query: 316 RAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQA 375
           R   RY PE +T+T +  + + R Q+ N G G ++D +F     L    +DDTE  LL A
Sbjct: 265 RICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSA 324

Query: 376 VLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACH 435
           + L+  DR  L    +++K Q+  L A + YI  R+    H +PK+LMK+TDLR I A  
Sbjct: 325 ICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKG 384

Query: 436 ASRFLHMKVECPTELFPPLFLEVFED 461
           A R + +K+E P  + PPL  E+ E+
Sbjct: 385 AERVITLKMEIPGSM-PPLIQEMLEN 409


>gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens]
          Length = 457

 Score =  234 bits (598), Expect = 9e-62
 Identities = 136/386 (35%), Positives = 205/386 (53%), Gaps = 32/386 (8%)

Query: 82  SAQTFQTEEKKCKGYIPSYLDKDEL------CVVCGDKATGYHYRCITCEGCKGFFRRTI 135
           S  + +T+    +  +PS      L      C VC DK++GYHY    CEGCKGFFRR+I
Sbjct: 52  SNHSIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSI 111

Query: 136 QKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEEN 195
           QKN+   Y+C  +  C+I+KVTRN+CQ CR +KC  VGM+ + V +D             
Sbjct: 112 QKNM--VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRND------------- 156

Query: 196 REKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPI 255
           R K+++E  +         T E  ELI+ V +AH  T        Q  K+   +  +  +
Sbjct: 157 RNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALC---QLGKYTTNNSSEQRV 213

Query: 256 VNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSL 315
                   +D++ +  F+++ T  I + V+FAK+LP F  L   DQI LLK  C++I+ L
Sbjct: 214 -------SLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILIL 266

Query: 316 RAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQA 375
           R   RY PE +T+T +  + + R Q+ N G G ++D +F     L    +DD E  LL A
Sbjct: 267 RICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSA 326

Query: 376 VLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACH 435
           + L+  DR  L   +R++  Q+  L A + Y+  R+    H +PK+LMK+TDLR I A  
Sbjct: 327 ICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKG 386

Query: 436 ASRFLHMKVECPTELFPPLFLEVFED 461
           A R + +K+E P  + PPL  E+ E+
Sbjct: 387 AERVITLKMEIPGSM-PPLIQEMLEN 411


>gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens]
          Length = 443

 Score =  231 bits (590), Expect = 8e-61
 Identities = 136/387 (35%), Positives = 209/387 (54%), Gaps = 32/387 (8%)

Query: 81  SSAQTFQTEEKKCKGYIPSYLDKD------ELCVVCGDKATGYHYRCITCEGCKGFFRRT 134
           +S Q+ +T+    +  +PS           + C VC DK++GYHY   +CEGCKGFFRR+
Sbjct: 47  ASLQSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRS 106

Query: 135 IQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEE 194
           IQKN+   Y+C  +  C+I+KVTRN+CQ CR +KC  VGM+ + V +D            
Sbjct: 107 IQKNM--VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRND------------ 152

Query: 195 NREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAP 254
            R K+++E  ++      E + +  ELI  V++AH  T        Q  K+         
Sbjct: 153 -RNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLC---QLGKYTTNS----- 203

Query: 255 IVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMS 314
             +A    ++DL  +  F+++ T  I ++V+FAK+LP F  L   DQI LLK  C++I+ 
Sbjct: 204 --SADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILM 261

Query: 315 LRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQ 374
           LR   RY PE +T+T +  + + R Q+ N G G ++D +F     L    +DDTE  LL 
Sbjct: 262 LRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLS 321

Query: 375 AVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGAC 434
           A+ L+  DR  L   E+++K Q+  L A   Y   R+    + +P++LMK+TDLR I   
Sbjct: 322 AICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTK 381

Query: 435 HASRFLHMKVECPTELFPPLFLEVFED 461
            A R + +K+E P  + PPL  E+ E+
Sbjct: 382 GAERAITLKMEIPGPM-PPLIREMLEN 407


>gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens]
          Length = 454

 Score =  231 bits (588), Expect = 1e-60
 Identities = 131/355 (36%), Positives = 197/355 (55%), Gaps = 26/355 (7%)

Query: 107 CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRF 166
           C VC DK++GYHY   +CEGCKGFFRR+IQKN+   Y+C  +  C+I+KVTRN+CQ CR 
Sbjct: 90  CFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNM--VYTCHRDKNCIINKVTRNRCQYCRL 147

Query: 167 KKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVT 226
           +KC  VGM+ + V +D             R K+++E  ++      E + +  ELI  V+
Sbjct: 148 QKCFEVGMSKEAVRND-------------RNKKKKEVKEEGSPDSYELSPQLEELITKVS 194

Query: 227 EAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDF 286
           +AH  T        Q  K+           +A    ++DL  +  F+++ T  I ++V+F
Sbjct: 195 KAHQETFPSLC---QLGKYTTNS-------SADHRVQLDLGLWDKFSELATKCIIKIVEF 244

Query: 287 AKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGL 346
           AK+LP F  L   DQI LLK  C++I+ LR   RY PE +T+T +  + + R Q+ N G 
Sbjct: 245 AKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGF 304

Query: 347 GVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHY 406
           G ++D +F     L    +DDTE  LL A+ L+  DR  L   E+++K Q+  L A   Y
Sbjct: 305 GPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLY 364

Query: 407 INYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED 461
              R+    + +P++LMK+TDLR I    A R + +K+E P  + PPL  E+ E+
Sbjct: 365 ARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPM-PPLIREMLEN 418


>gi|194294519 nuclear receptor subfamily 1, group H, member 3
           isoform c [Homo sapiens]
          Length = 402

 Score =  209 bits (531), Expect = 6e-54
 Identities = 123/375 (32%), Positives = 204/375 (54%), Gaps = 16/375 (4%)

Query: 90  EKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEG 149
           +K+ KG  P  L  +ELC VCGDKA+G+HY  ++CEGCKGFFRR++ K  H  Y C   G
Sbjct: 37  QKRKKGPAPKMLG-NELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAH--YICHSGG 93

Query: 150 KCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSK-RLAKRKLIEENREKRRREELQKSI 208
            C +D   R +CQECR +KC   GM  + VL + + RL K K  EE +        + S 
Sbjct: 94  HCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASS 153

Query: 209 GHK--PEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDL 266
             +  P+ + E+  +I+ +  A    N +   +  + +  P      P+   P   +   
Sbjct: 154 PPQILPQLSPEQLGMIEKLVAAQQQCNRRS--FSDRLRVTPW-----PMAPDPHSREARQ 206

Query: 267 EAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESE 326
           + F+HFT++   ++  +VDFAK+LP F +L  EDQI LLK   +E+M L  + RY+P SE
Sbjct: 207 QRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSE 266

Query: 327 TLTLNGEMAVTRGQLKNGGLGV-VSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPG 385
           ++T   + +  R      GL V   + IF+   +++   L+D E ALL A+ + S+DRP 
Sbjct: 267 SITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPN 326

Query: 386 LACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVE 445
           +    ++E+ Q +++ A   Y++    H    +P++LMK+  LR + + H+ +   ++++
Sbjct: 327 VQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQ 386

Query: 446 CPTELFPPLFLEVFE 460
              +  PPL  E+++
Sbjct: 387 --DKKLPPLLSEIWD 399


>gi|194294517 nuclear receptor subfamily 1, group H, member 3
           isoform a [Homo sapiens]
          Length = 447

 Score =  209 bits (531), Expect = 6e-54
 Identities = 123/375 (32%), Positives = 204/375 (54%), Gaps = 16/375 (4%)

Query: 90  EKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEG 149
           +K+ KG  P  L  +ELC VCGDKA+G+HY  ++CEGCKGFFRR++ K  H  Y C   G
Sbjct: 82  QKRKKGPAPKMLG-NELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAH--YICHSGG 138

Query: 150 KCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSK-RLAKRKLIEENREKRRREELQKSI 208
            C +D   R +CQECR +KC   GM  + VL + + RL K K  EE +        + S 
Sbjct: 139 HCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASS 198

Query: 209 GHK--PEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDL 266
             +  P+ + E+  +I+ +  A    N +   +  + +  P      P+   P   +   
Sbjct: 199 PPQILPQLSPEQLGMIEKLVAAQQQCNRRS--FSDRLRVTPW-----PMAPDPHSREARQ 251

Query: 267 EAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESE 326
           + F+HFT++   ++  +VDFAK+LP F +L  EDQI LLK   +E+M L  + RY+P SE
Sbjct: 252 QRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSE 311

Query: 327 TLTLNGEMAVTRGQLKNGGLGV-VSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPG 385
           ++T   + +  R      GL V   + IF+   +++   L+D E ALL A+ + S+DRP 
Sbjct: 312 SITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPN 371

Query: 386 LACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVE 445
           +    ++E+ Q +++ A   Y++    H    +P++LMK+  LR + + H+ +   ++++
Sbjct: 372 VQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQ 431

Query: 446 CPTELFPPLFLEVFE 460
              +  PPL  E+++
Sbjct: 432 --DKKLPPLLSEIWD 444


>gi|85362735 nuclear receptor subfamily 1, group H, member 2 [Homo
           sapiens]
          Length = 461

 Score =  194 bits (492), Expect = 2e-49
 Identities = 117/396 (29%), Positives = 198/396 (50%), Gaps = 27/396 (6%)

Query: 87  QTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCK 146
           + E K+ KG  P  L   ELC VCGDKA+G+HY  ++CEGCKGFFRR++ +     Y+C+
Sbjct: 68  EPERKRKKGPAPKMLGH-ELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACR 126

Query: 147 YEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQK 206
             G C +D   R +CQ+CR +KC   GM    VL + +   ++K I + +++  + + Q 
Sbjct: 127 GGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQ--IRKKKIRKQQQQESQSQSQS 184

Query: 207 SIGHKPEPT--------------------DEEWELIKTVTEAHVATNAQGSHWKQKRKFL 246
            +G +   +                    + E   +    E  +           KR F 
Sbjct: 185 PVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFS 244

Query: 247 PED-IGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILL 305
            +  +   P+   P+      + F+HFT++   ++  +VDFAK++P F +L  EDQI LL
Sbjct: 245 DQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALL 304

Query: 306 KGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGV-VSDAIFDLGMSLSSFN 364
           K   +EIM L  A RY+ E+E +T   +   ++      GL V   + IF+   ++    
Sbjct: 305 KASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLG 364

Query: 365 LDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMK 424
           LDD E ALL A+ + S+DRP +    R+E  Q  ++ A   Y   ++      +P++LMK
Sbjct: 365 LDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMK 424

Query: 425 VTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFE 460
           +  LR + + H+ +   ++++   +  PPL  E+++
Sbjct: 425 LVSLRTLSSVHSEQVFALRLQ--DKKLPPLLSEIWD 458


>gi|7706625 retinoic acid receptor, beta isoform 2 [Homo sapiens]
          Length = 336

 Score =  189 bits (479), Expect = 6e-48
 Identities = 111/319 (34%), Positives = 170/319 (53%), Gaps = 24/319 (7%)

Query: 143 YSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRRE 202
           Y+C  +  CVI+KVTRN+CQ CR +KC  VGM+ + V +D             R K+++E
Sbjct: 3   YTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRND-------------RNKKKKE 49

Query: 203 ELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGG 262
             ++      E T E  +L + + +AH  T        Q  K+           +A    
Sbjct: 50  TSKQECTESYEMTAELDDLTEKIRKAHQETFPSLC---QLGKYTTNS-------SADHRV 99

Query: 263 KVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYD 322
           ++DL  +  F+++ T  I ++V+FAK+LP F  L   DQI LLK  C++I+ LR   RY 
Sbjct: 100 RLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYT 159

Query: 323 PESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSD 382
           PE +T+T +  + + R Q+ N G G ++D +F     L    +DDTE  LL A+ L+  D
Sbjct: 160 PEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGD 219

Query: 383 RPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHM 442
           R  L    +++K Q+  L A + YI  R+    H +PK+LMK+TDLR I A  A R + +
Sbjct: 220 RQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITL 279

Query: 443 KVECPTELFPPLFLEVFED 461
           K+E P  + PPL  E+ E+
Sbjct: 280 KMEIPGSM-PPLIQEMLEN 297


>gi|4826980 nuclear receptor subfamily 1, group H, member 4 [Homo
           sapiens]
          Length = 472

 Score =  173 bits (439), Expect = 3e-43
 Identities = 120/371 (32%), Positives = 179/371 (48%), Gaps = 38/371 (10%)

Query: 104 DELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQE 163
           DELCVVCGD+A+GYHY  +TCEGCKGFFRR+I KN    Y CK  G CV+D   R +CQE
Sbjct: 124 DELCVVCGDRASGYHYNALTCEGCKGFFRRSITKN--AVYKCKNGGNCVMDMYMRRKCQE 181

Query: 164 CRFKKCIYVGMATDLVLDD----SKRLAKR---------KLIEENREKRRREELQKSIGH 210
           CR +KC  +GM  + +L +    SKRL K              E R+ R+     KS   
Sbjct: 182 CRLRKCKEMGMLAECLLTEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTTKSCRE 241

Query: 211 KPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFS 270
           K E T ++  L+  + +++   N Q    +   K L E+                 E F 
Sbjct: 242 KTELTPDQQTLLHFIMDSY---NKQRMPQEITNKILKEEFSAE-------------ENFL 285

Query: 271 HFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTL 330
             T++ T  +  +V+F KKLP F  L  EDQI LLKG  +E M LR+A  ++ +      
Sbjct: 286 ILTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLP---- 341

Query: 331 NGEMAVTRGQLKNGGLG-VVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACV 389
           +G   +   +++N G+       +F    S+    +   E ALL A++++S DR  +   
Sbjct: 342 SGHSDLLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDR 401

Query: 390 ERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTE 449
           E +EK Q+  L   +      +      +  LL ++T+LR     HA   +  +V     
Sbjct: 402 EAVEKLQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVN--DH 459

Query: 450 LFPPLFLEVFE 460
            F PL  E+++
Sbjct: 460 KFTPLLCEIWD 470


>gi|14702164 nuclear receptor subfamily 1, group I, member 2 isoform
           3 [Homo sapiens]
          Length = 397

 Score =  172 bits (436), Expect = 6e-43
 Identities = 113/363 (31%), Positives = 178/363 (49%), Gaps = 17/363 (4%)

Query: 105 ELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKY-EGKCVIDKVTRNQCQE 163
           ++C VCGDKATGYH+  +TCEGCKGFFRR +++N      C + +G C I + TR QCQ 
Sbjct: 39  QICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNAR--LRCPFRKGACEITRKTRRQCQA 96

Query: 164 CRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIK 223
           CR +KC+  GM  ++++ D     +R LI+  + +R   +     G     T+E+  +I+
Sbjct: 97  CRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQG----LTEEQRMMIR 152

Query: 224 TVTEAHVAT-NAQGSHWKQKRKFLPEDIGQAPIVN----APEGGKVDLEAFSHFTKIITP 278
            + +A + T +   SH+K  R  L        + N    A  GGK       H   + T 
Sbjct: 153 ELMDAQMKTFDTTFSHFKNFRVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTY 212

Query: 279 AITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTR 338
               ++ FAK +  F +LP EDQI LLKG   E+  LR    ++ E+ T    G ++   
Sbjct: 213 MFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWEC-GRLSYCL 271

Query: 339 GQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDS 398
                G   ++ + +      L    L + E  L+QA+ L S DRPG+     +++ Q+ 
Sbjct: 272 EDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQ 331

Query: 399 FLLAFEHYINYRKHHVTH--FWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFL 456
           F +  + YI   +    H   + K++  +T+LR I A H  R L ++   P     PL  
Sbjct: 332 FAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHP--FATPLMQ 389

Query: 457 EVF 459
           E+F
Sbjct: 390 ELF 392


>gi|4826661 constitutive androstane receptor isoform 3 [Homo
           sapiens]
          Length = 348

 Score =  169 bits (429), Expect = 4e-42
 Identities = 116/350 (33%), Positives = 174/350 (49%), Gaps = 29/350 (8%)

Query: 103 KDEL--CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQ 160
           +DEL  CVVCGD+ATGYH+  +TCEGCKGFFRRT+ K++ P  +C + G C + K  R  
Sbjct: 5   EDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGP--TCPFAGSCEVSKTQRRH 62

Query: 161 CQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWE 220
           C  CR +KC+  GM  D++L       +R    + R ++   +L K          E+ E
Sbjct: 63  CPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSK----------EQEE 112

Query: 221 LIKTVTEAHVATNAQGSHWKQKRKFLPED---IGQAPIVN-APEGGKVDLEAFSHFTKII 276
           LI+T+  AH  T   G+ ++Q  +F P     I   P+   AP      L   +HF  I 
Sbjct: 113 LIRTLLGAH--TRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPV-----LPLVTHFADIN 165

Query: 277 TPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAV 336
           T  + +V+ F K LP+F  LP EDQI LLKG  +EI  +     +  +++   L G +  
Sbjct: 166 TFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNF-LCGPLRY 224

Query: 337 TRGQLKNGGLGV-VSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKY 395
           T       G  V   + +F    +L    L + E  LL A+ L S DRPG+   + I++ 
Sbjct: 225 TIEDGARVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGVTQRDEIDQL 284

Query: 396 QDSFLLAFEHYI--NYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMK 443
           Q+   L  + YI    R+      + KLL  + +LR I   +  +  H++
Sbjct: 285 QEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQ 334


>gi|117938752 constitutive androstane receptor isoform 2 [Homo
           sapiens]
          Length = 352

 Score =  166 bits (421), Expect = 3e-41
 Identities = 116/354 (32%), Positives = 174/354 (49%), Gaps = 33/354 (9%)

Query: 103 KDEL--CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQ 160
           +DEL  CVVCGD+ATGYH+  +TCEGCKGFFRRT+ K++ P  +C + G C + K  R  
Sbjct: 5   EDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGP--TCPFAGSCEVSKTQRRH 62

Query: 161 CQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWE 220
           C  CR +KC+  GM  D++L       +R    + R ++   +L K          E+ E
Sbjct: 63  CPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSK----------EQEE 112

Query: 221 LIKTVTEAHVATNAQGSHWKQKRKFLPED---IGQAPIVN-APEGGKVDLEAFSHFTKII 276
           LI+T+  AH  T   G+ ++Q  +F P     I   P+   AP      L   +HF  I 
Sbjct: 113 LIRTLLGAH--TRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPV-----LPLVTHFADIN 165

Query: 277 TPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAV 336
           T  + +V+ F K LP+F  LP EDQI LLKG  +EI  +     +  +++   L G +  
Sbjct: 166 TFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNF-LCGPLRY 224

Query: 337 T-----RGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVER 391
           T     R     G      + +F    +L    L + E  LL A+ L S DRPG+   + 
Sbjct: 225 TIEDGARVSPTVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGVTQRDE 284

Query: 392 IEKYQDSFLLAFEHYI--NYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMK 443
           I++ Q+   L  + YI    R+      + KLL  + +LR I   +  +  H++
Sbjct: 285 IDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQ 338


>gi|117938756 constitutive androstane receptor isoform 1 [Homo
           sapiens]
          Length = 357

 Score =  161 bits (407), Expect = 1e-39
 Identities = 116/359 (32%), Positives = 175/359 (48%), Gaps = 38/359 (10%)

Query: 103 KDEL--CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQ 160
           +DEL  CVVCGD+ATGYH+  +TCEGCKGFFRRT+ K++ P  +C + G C + K  R  
Sbjct: 5   EDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGP--TCPFAGSCEVSKTQRRH 62

Query: 161 CQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWE 220
           C  CR +KC+  GM  D++L       +R    + R ++   +L K          E+ E
Sbjct: 63  CPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSK----------EQEE 112

Query: 221 LIKTVTEAHVATNAQGSHWKQKRKFLPED---IGQAPIVN-APEGGKVDLEAFSHFTKII 276
           LI+T+  AH  T   G+ ++Q  +F P     I   P+   AP      L   +HF  I 
Sbjct: 113 LIRTLLGAH--TRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPV-----LPLVTHFADIN 165

Query: 277 TPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAV 336
           T  + +V+ F K LP+F  LP EDQI LLKG  +EI  +     +  +++   L G +  
Sbjct: 166 TFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNF-LCGPLRY 224

Query: 337 T-----RGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMS-----SDRPGL 386
           T     R     G      + +F    +L    L + E  LL A+ L S     +DRPG+
Sbjct: 225 TIEDGARVSPTVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPAPYLTDRPGV 284

Query: 387 ACVERIEKYQDSFLLAFEHYI--NYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMK 443
              + I++ Q+   L  + YI    R+      + KLL  + +LR I   +  +  H++
Sbjct: 285 TQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQ 343


>gi|63054845 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo
           sapiens]
          Length = 427

 Score =  160 bits (406), Expect = 2e-39
 Identities = 115/410 (28%), Positives = 195/410 (47%), Gaps = 66/410 (16%)

Query: 106 LCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECR 165
           +C VCGD+ATG+H+  +TCEGCKGFFRR++++     ++C + G C I K  R  CQ CR
Sbjct: 23  ICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRK--ALFTCPFNGDCRITKDNRRHCQACR 80

Query: 166 FKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTV 225
            K+C+ +GM  + +L D +   KR++I + +E+   E L+ S+  +P+ ++E+  +I  +
Sbjct: 81  LKRCVDIGMMKEFILTDEEVQRKREMILKRKEE---EALKDSL--RPKLSEEQQRIIAIL 135

Query: 226 TEAHVAT------------------NAQGSH-WKQKRKFLPEDIG------------QAP 254
            +AH  T                  +  GSH  +   +  P   G             + 
Sbjct: 136 LDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSD 195

Query: 255 IVNAPEGGKVD-----------------LEAFSHFTKIITPAITRVVDFAKKLPMFCELP 297
           ++++     +D                 L    H   +++ +I +V+ FAK +P F +L 
Sbjct: 196 MMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLT 255

Query: 298 CEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTR--GQLKNGGLGVVSDAIFD 355
            EDQI+LLK   +E++ LR+   +  +  + T   +    R     K G    + + +  
Sbjct: 256 SEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIK 315

Query: 356 LGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRK---- 411
             + L   NL + E  LL A+ ++S DRPG+     IE  QD      + YI  R     
Sbjct: 316 FQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPG 375

Query: 412 HHVTHFWPKLLMKVTDLRMIGACHASRF--LHMKVECPTELFPPLFLEVF 459
            H+   + K++ K+ DLR +   H+ ++  L  + EC  +L  PL LEVF
Sbjct: 376 SHL--LYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKL-TPLVLEVF 422


>gi|4507883 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo
           sapiens]
          Length = 427

 Score =  160 bits (406), Expect = 2e-39
 Identities = 115/410 (28%), Positives = 195/410 (47%), Gaps = 66/410 (16%)

Query: 106 LCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECR 165
           +C VCGD+ATG+H+  +TCEGCKGFFRR++++     ++C + G C I K  R  CQ CR
Sbjct: 23  ICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRK--ALFTCPFNGDCRITKDNRRHCQACR 80

Query: 166 FKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTV 225
            K+C+ +GM  + +L D +   KR++I + +E+   E L+ S+  +P+ ++E+  +I  +
Sbjct: 81  LKRCVDIGMMKEFILTDEEVQRKREMILKRKEE---EALKDSL--RPKLSEEQQRIIAIL 135

Query: 226 TEAHVAT------------------NAQGSH-WKQKRKFLPEDIG------------QAP 254
            +AH  T                  +  GSH  +   +  P   G             + 
Sbjct: 136 LDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSD 195

Query: 255 IVNAPEGGKVD-----------------LEAFSHFTKIITPAITRVVDFAKKLPMFCELP 297
           ++++     +D                 L    H   +++ +I +V+ FAK +P F +L 
Sbjct: 196 MMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLT 255

Query: 298 CEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTR--GQLKNGGLGVVSDAIFD 355
            EDQI+LLK   +E++ LR+   +  +  + T   +    R     K G    + + +  
Sbjct: 256 SEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIK 315

Query: 356 LGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRK---- 411
             + L   NL + E  LL A+ ++S DRPG+     IE  QD      + YI  R     
Sbjct: 316 FQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPG 375

Query: 412 HHVTHFWPKLLMKVTDLRMIGACHASRF--LHMKVECPTELFPPLFLEVF 459
            H+   + K++ K+ DLR +   H+ ++  L  + EC  +L  PL LEVF
Sbjct: 376 SHL--LYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKL-TPLVLEVF 422


>gi|117938746 constitutive androstane receptor isoform 7 [Homo
           sapiens]
          Length = 339

 Score =  159 bits (403), Expect = 4e-39
 Identities = 108/316 (34%), Positives = 158/316 (50%), Gaps = 31/316 (9%)

Query: 103 KDEL--CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQ 160
           +DEL  CVVCGD+ATGYH+  +TCEGCKGFFRRT+ K++ P  +C + G C + K  R  
Sbjct: 5   EDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGP--TCPFAGSCEVSKTQRRH 62

Query: 161 CQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWE 220
           C  CR +KC+  GM  D++L       +R    + R ++   +L K          E+ E
Sbjct: 63  CPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSK----------EQEE 112

Query: 221 LIKTVTEAHVATNAQGSHWKQKRKFLPED---IGQAPIVN-APEGGKVDLEAFSHFTKII 276
           LI+T+  AH  T   G+ ++Q  +F P     I   P+   AP      L   +HF  I 
Sbjct: 113 LIRTLLGAH--TRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPV-----LPLVTHFADIN 165

Query: 277 TPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAV 336
           T  + +V+ F K LP+F  LP EDQI LLKG  +EI  +     +  +++   L G +  
Sbjct: 166 TFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNF-LCGPLRY 224

Query: 337 T-----RGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVER 391
           T     R     G      + +F    +L    L + E  LL A+ L S DRPG+   + 
Sbjct: 225 TIEDGARVSPTVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGVTQRDE 284

Query: 392 IEKYQDSFLLAFEHYI 407
           I++ Q+   L  + YI
Sbjct: 285 IDQLQEEMALTLQSYI 300


>gi|117938729 constitutive androstane receptor isoform 6 [Homo
           sapiens]
          Length = 340

 Score =  157 bits (397), Expect = 2e-38
 Identities = 108/317 (34%), Positives = 159/317 (50%), Gaps = 32/317 (10%)

Query: 103 KDEL--CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQ 160
           +DEL  CVVCGD+ATGYH+  +TCEGCKGFFRRT+ K++ P  +C + G C + K  R  
Sbjct: 5   EDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGP--TCPFAGSCEVSKTQRRH 62

Query: 161 CQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWE 220
           C  CR +KC+  GM  D++L       +R    + R ++   +L K          E+ E
Sbjct: 63  CPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSK----------EQEE 112

Query: 221 LIKTVTEAHVATNAQGSHWKQKRKFLPED---IGQAPIVN-APEGGKVDLEAFSHFTKII 276
           LI+T+  AH  T   G+ ++Q  +F P     I   P+   AP      L   +HF  I 
Sbjct: 113 LIRTLLGAH--TRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPV-----LPLVTHFADIN 165

Query: 277 TPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAV 336
           T  + +V+ F K LP+F  LP EDQI LLKG  +EI  +     +  +++   L G +  
Sbjct: 166 TFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNF-LCGPLRY 224

Query: 337 TRGQLKNGGLGV-VSDAIFDLGMSLSSFNLDDTEVALLQAVLLMS-----SDRPGLACVE 390
           T       G  V   + +F    +L    L + E  LL A+ L S     +DRPG+   +
Sbjct: 225 TIEDGARVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPAPYLTDRPGVTQRD 284

Query: 391 RIEKYQDSFLLAFEHYI 407
            I++ Q+   L  + YI
Sbjct: 285 EIDQLQEEMALTLQSYI 301


>gi|5453940 peroxisome proliferative activated receptor, delta
           isoform 1 [Homo sapiens]
          Length = 441

 Score =  152 bits (384), Expect = 6e-37
 Identities = 116/374 (31%), Positives = 178/374 (47%), Gaps = 27/374 (7%)

Query: 107 CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRF 166
           C VCGDKA+G+HY    CEGCKGFFRRTI+  L      K E  C I K  RN+CQ CRF
Sbjct: 74  CRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYE---KCERSCKIQKKNRNKCQYCRF 130

Query: 167 KKCIYVGMATDLV-LDDSKRLAKRKLI------EENREKRRREELQKSIGHKPEPTDEEW 219
           +KC+ +GM+ + +         KRKL+      E ++   +  +L+    H      + +
Sbjct: 131 QKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNF 190

Query: 220 ELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAP-------IVNA-PEGGKVDLEAFSH 271
            + K   +A      + SH         E + QA        +VN  P   ++ +  F  
Sbjct: 191 NMTKK--KARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYR 248

Query: 272 FTKIITPAITRVVDFAKKLPMFCELPCEDQIILLK-GCCMEIMSLRAAVRYDPESETLTL 330
                   +  + +FAK +P F  L   DQ+ LLK G    I ++ A++    +   L  
Sbjct: 249 CQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVN--KDGLLVA 306

Query: 331 NGEMAVTRGQLKN--GGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLAC 388
           NG   VTR  L++       + +  F+  +  ++  LDD+++AL  A +++  DRPGL  
Sbjct: 307 NGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMN 366

Query: 389 VERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHM-KVECP 447
           V R+E  QD+ L A E ++        + +PKLL K+ DLR +   HA     + K E  
Sbjct: 367 VPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETE 426

Query: 448 TELFPPLFLEVFED 461
           T L  PL  E+++D
Sbjct: 427 TSLH-PLLQEIYKD 439


>gi|223718070 retinoic acid receptor, alpha isoform 4 [Homo sapiens]
          Length = 365

 Score =  150 bits (380), Expect = 2e-36
 Identities = 88/270 (32%), Positives = 141/270 (52%), Gaps = 11/270 (4%)

Query: 192 IEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIG 251
           +  +R K+++E  +         T E  ELI+ V +AH  T        Q  K+   +  
Sbjct: 61  VRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALC---QLGKYTTNNSS 117

Query: 252 QAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCME 311
           +  +        +D++ +  F+++ T  I + V+FAK+LP F  L   DQI LLK  C++
Sbjct: 118 EQRV-------SLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLD 170

Query: 312 IMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVA 371
           I+ LR   RY PE +T+T +  + + R Q+ N G G ++D +F     L    +DD E  
Sbjct: 171 ILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETG 230

Query: 372 LLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMI 431
           LL A+ L+  DR  L   +R++  Q+  L A + Y+  R+    H +PK+LMK+TDLR I
Sbjct: 231 LLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSI 290

Query: 432 GACHASRFLHMKVECPTELFPPLFLEVFED 461
            A  A R + +K+E P  + PPL  E+ E+
Sbjct: 291 SAKGAERVITLKMEIPGSM-PPLIQEMLEN 319


>gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo
           sapiens]
          Length = 598

 Score =  150 bits (379), Expect = 2e-36
 Identities = 103/350 (29%), Positives = 168/350 (48%), Gaps = 29/350 (8%)

Query: 106 LCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECR 165
           LC VCGD A   HY   TCEGCKGFF+RT+QKN    Y C     C +DK  RN+CQ CR
Sbjct: 262 LCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKN--AKYVCLANKNCPVDKRRRNRCQYCR 319

Query: 166 FKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTV 225
           F+KC+ VGM  ++V  DS +  + +L  + +  +           +P P      LI  +
Sbjct: 320 FQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKSPQ-----------EPSPPSPPVSLISAL 368

Query: 226 TEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVD 285
             AHV +N   +     R     D          +    D +    F  ++T ++  +  
Sbjct: 369 VRAHVDSNPAMTSLDYSRFQANPDY---------QMSGDDTQHIQQFYDLLTGSMEIIRG 419

Query: 286 FAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGG 345
           +A+K+P F +LP  DQ +L +   +E+  LR A R +P    L     + + R Q    G
Sbjct: 420 WAEKIPGFADLPKADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVR-G 478

Query: 346 LGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEH 405
            G   D+I +   +L + N+D +  + + A L M ++R GL   +R+E+ Q+  +   + 
Sbjct: 479 FGEWIDSIVEFSSNLQNMNIDISAFSCI-AALAMVTERHGLKEPKRVEELQNKIVNCLKD 537

Query: 406 YINYRKHHVT--HFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPP 453
           ++ +    +   ++  KLL K+ +LR +      R  ++K+E   +L PP
Sbjct: 538 HVTFNNGGLNRPNYLSKLLGKLPELRTLCTQGLQRIFYLKLE---DLVPP 584


>gi|4506755 retinoid X receptor, alpha [Homo sapiens]
          Length = 462

 Score =  148 bits (374), Expect = 9e-36
 Identities = 89/328 (27%), Positives = 165/328 (50%), Gaps = 33/328 (10%)

Query: 106 LCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECR 165
           +C +CGD+++G HY   +CEGCKGFF+RT++K+L  +Y+C+    C+IDK  RN+CQ CR
Sbjct: 134 ICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDL--TYTCRDNKDCLIDKRQRNRCQYCR 191

Query: 166 FKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTV 225
           ++KC+ +GM  + V ++ +R          +++   E    S  ++  P       ++ +
Sbjct: 192 YQKCLAMGMKREAVQEERQR---------GKDRNENEVESTSSANEDMP-------VERI 235

Query: 226 TEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVD 285
            EA +A   +   + +    L       P+ N  +    D + F+            +V+
Sbjct: 236 LEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQA--ADKQLFT------------LVE 281

Query: 286 FAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGG 345
           +AK++P F ELP +DQ+ILL+    E++    + R     + + L   + V R    + G
Sbjct: 282 WAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAG 341

Query: 346 LGVVSDAIF-DLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFE 404
           +G + D +  +L   +    +D TE+  L+A++L + D  GL+    +E  ++    + E
Sbjct: 342 VGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLE 401

Query: 405 HYINYRKHHVTHFWPKLLMKVTDLRMIG 432
            Y  ++       + KLL+++  LR IG
Sbjct: 402 AYCKHKYPEQPGRFAKLLLRLPALRSIG 429


>gi|117938754 constitutive androstane receptor isoform 4 [Homo
           sapiens]
          Length = 314

 Score =  145 bits (366), Expect = 8e-35
 Identities = 110/349 (31%), Positives = 162/349 (46%), Gaps = 61/349 (17%)

Query: 103 KDEL--CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQ 160
           +DEL  CVVCGD+ATGYH+  +TCEGCKGFFRRT+ K++ P  +C + G C + K  R  
Sbjct: 5   EDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGP--TCPFAGSCEVSKTQRRH 62

Query: 161 CQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWE 220
           C  CR +KC+  GM  D++L       +R    + R ++   +L K          E+ E
Sbjct: 63  CPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSK----------EQEE 112

Query: 221 LIKTVTEAHVATNAQGSHWKQKRKFLPED---IGQAPIVN-APEGGKVDLEAFSHFTKII 276
           LI+T+  AH  T   G+ ++Q  +F P     I   P+   AP      L   +HF  I 
Sbjct: 113 LIRTLLGAH--TRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPV-----LPLVTHFADIN 165

Query: 277 TPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAV 336
           T  + +V+ F K LP+F  LP EDQI LLKG  +EI               + LN    +
Sbjct: 166 TFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICH-------------IVLNTTFCL 212

Query: 337 TRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQ 396
              Q +N   G +   I D                   A     +DRPG+   + I++ Q
Sbjct: 213 ---QTQNFLCGPLRYTIED------------------GARAPYLTDRPGVTQRDEIDQLQ 251

Query: 397 DSFLLAFEHYI--NYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMK 443
           +   L  + YI    R+      + KLL  + +LR I   +  +  H++
Sbjct: 252 EEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQ 300


>gi|117938734 constitutive androstane receptor isoform 5 [Homo
           sapiens]
          Length = 309

 Score =  145 bits (366), Expect = 8e-35
 Identities = 107/349 (30%), Positives = 160/349 (45%), Gaps = 66/349 (18%)

Query: 103 KDEL--CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQ 160
           +DEL  CVVCGD+ATGYH+  +TCEGCKGFFRRT+ K++ P  +C + G C + K  R  
Sbjct: 5   EDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGP--TCPFAGSCEVSKTQRRH 62

Query: 161 CQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWE 220
           C  CR +KC+  GM  D++L       +R    + R ++   +L K          E+ E
Sbjct: 63  CPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSK----------EQEE 112

Query: 221 LIKTVTEAHVATNAQGSHWKQKRKFLPED---IGQAPIVN-APEGGKVDLEAFSHFTKII 276
           LI+T+  AH  T   G+ ++Q  +F P     I   P+   AP      L   +HF  I 
Sbjct: 113 LIRTLLGAH--TRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPV-----LPLVTHFADIN 165

Query: 277 TPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAV 336
           T  + +V+ F K LP+F  LP EDQI LLKG  +EI               + LN    +
Sbjct: 166 TFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICH-------------IVLNTTFCL 212

Query: 337 TRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQ 396
                  G L                + ++D            + DRPG+   + I++ Q
Sbjct: 213 QTQNFLCGPL---------------RYTIEDG-----------ARDRPGVTQRDEIDQLQ 246

Query: 397 DSFLLAFEHYI--NYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMK 443
           +   L  + YI    R+      + KLL  + +LR I   +  +  H++
Sbjct: 247 EEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQ 295


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.135    0.419 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,378,710
Number of Sequences: 37866
Number of extensions: 844641
Number of successful extensions: 3078
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 129
Number of HSP's successfully gapped in prelim test: 28
Number of HSP's that attempted gapping in prelim test: 2644
Number of HSP's gapped (non-prelim): 253
length of query: 461
length of database: 18,247,518
effective HSP length: 106
effective length of query: 355
effective length of database: 14,233,722
effective search space: 5052971310
effective search space used: 5052971310
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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