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Search of human proteins with 189491769
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|189491769 thyroid hormone receptor, beta [Homo sapiens]
(461 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|189491771 thyroid hormone receptor, beta [Homo sapiens] 959 0.0
gi|189491769 thyroid hormone receptor, beta [Homo sapiens] 959 0.0
gi|40806162 thyroid hormone receptor, beta [Homo sapiens] 959 0.0
gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo sapi... 654 0.0
gi|20127452 thyroid hormone receptor, alpha isoform 2 [Homo sapi... 577 e-165
gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 238 7e-63
gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 238 7e-63
gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens] 237 1e-62
gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens] 234 9e-62
gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens] 231 8e-61
gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens] 231 1e-60
gi|194294519 nuclear receptor subfamily 1, group H, member 3 iso... 209 6e-54
gi|194294517 nuclear receptor subfamily 1, group H, member 3 iso... 209 6e-54
gi|85362735 nuclear receptor subfamily 1, group H, member 2 [Hom... 194 2e-49
gi|7706625 retinoic acid receptor, beta isoform 2 [Homo sapiens] 189 6e-48
gi|4826980 nuclear receptor subfamily 1, group H, member 4 [Homo... 173 3e-43
gi|14702164 nuclear receptor subfamily 1, group I, member 2 isof... 172 6e-43
gi|4826661 constitutive androstane receptor isoform 3 [Homo sapi... 169 4e-42
gi|117938752 constitutive androstane receptor isoform 2 [Homo sa... 166 3e-41
gi|117938756 constitutive androstane receptor isoform 1 [Homo sa... 161 1e-39
gi|63054845 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo ... 160 2e-39
gi|4507883 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo s... 160 2e-39
gi|117938746 constitutive androstane receptor isoform 7 [Homo sa... 159 4e-39
gi|117938729 constitutive androstane receptor isoform 6 [Homo sa... 157 2e-38
gi|5453940 peroxisome proliferative activated receptor, delta is... 152 6e-37
gi|223718070 retinoic acid receptor, alpha isoform 4 [Homo sapiens] 150 2e-36
gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo... 150 2e-36
gi|4506755 retinoid X receptor, alpha [Homo sapiens] 148 9e-36
gi|117938754 constitutive androstane receptor isoform 4 [Homo sa... 145 8e-35
gi|117938734 constitutive androstane receptor isoform 5 [Homo sa... 145 8e-35
>gi|189491771 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 959 bits (2479), Expect = 0.0
Identities = 461/461 (100%), Positives = 461/461 (100%)
Query: 1 MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQ 60
MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQ
Sbjct: 1 MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQ 60
Query: 61 TTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR 120
TTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR
Sbjct: 61 TTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR 120
Query: 121 CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL 180
CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL
Sbjct: 121 CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL 180
Query: 181 DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK 240
DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK
Sbjct: 181 DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK 240
Query: 241 QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED 300
QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED
Sbjct: 241 QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED 300
Query: 301 QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL 360
QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL
Sbjct: 301 QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL 360
Query: 361 SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK 420
SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK
Sbjct: 361 SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK 420
Query: 421 LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED 461
LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
Sbjct: 421 LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED 461
>gi|189491769 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 959 bits (2479), Expect = 0.0
Identities = 461/461 (100%), Positives = 461/461 (100%)
Query: 1 MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQ 60
MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQ
Sbjct: 1 MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQ 60
Query: 61 TTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR 120
TTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR
Sbjct: 61 TTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR 120
Query: 121 CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL 180
CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL
Sbjct: 121 CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL 180
Query: 181 DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK 240
DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK
Sbjct: 181 DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK 240
Query: 241 QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED 300
QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED
Sbjct: 241 QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED 300
Query: 301 QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL 360
QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL
Sbjct: 301 QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL 360
Query: 361 SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK 420
SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK
Sbjct: 361 SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK 420
Query: 421 LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED 461
LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
Sbjct: 421 LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED 461
>gi|40806162 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 959 bits (2479), Expect = 0.0
Identities = 461/461 (100%), Positives = 461/461 (100%)
Query: 1 MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQ 60
MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQ
Sbjct: 1 MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQ 60
Query: 61 TTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR 120
TTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR
Sbjct: 61 TTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR 120
Query: 121 CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL 180
CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL
Sbjct: 121 CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL 180
Query: 181 DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK 240
DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK
Sbjct: 181 DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK 240
Query: 241 QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED 300
QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED
Sbjct: 241 QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED 300
Query: 301 QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL 360
QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL
Sbjct: 301 QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL 360
Query: 361 SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK 420
SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK
Sbjct: 361 SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK 420
Query: 421 LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED 461
LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
Sbjct: 421 LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED 461
>gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo
sapiens]
Length = 410
Score = 654 bits (1686), Expect = 0.0
Identities = 310/367 (84%), Positives = 342/367 (93%)
Query: 95 GYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVID 154
GYIPSYLDKDE CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHP+YSCKY+ CVID
Sbjct: 41 GYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVID 100
Query: 155 KVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEP 214
K+TRNQCQ CRFKKCI VGMA DLVLDDSKR+AKRKLIE+NRE+RR+EE+ +S+ +PEP
Sbjct: 101 KITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEP 160
Query: 215 TDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTK 274
T EEW+LI TEAH +TNAQGSHWKQ+RKFLP+DIGQ+PIV+ P+G KVDLEAFS FTK
Sbjct: 161 TPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTK 220
Query: 275 IITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEM 334
IITPAITRVVDFAKKLPMF ELPCEDQIILLKGCCMEIMSLRAAVRYDPES+TLTL+GEM
Sbjct: 221 IITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEM 280
Query: 335 AVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEK 394
AV R QLKNGGLGVVSDAIF+LG SLS+FNLDDTEVALLQAVLLMS+DR GL CV++IEK
Sbjct: 281 AVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEK 340
Query: 395 YQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPL 454
Q+++LLAFEHY+N+RKH++ HFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPL
Sbjct: 341 SQEAYLLAFEHYVNHRKHNIPHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPL 400
Query: 455 FLEVFED 461
FLEVFED
Sbjct: 401 FLEVFED 407
>gi|20127452 thyroid hormone receptor, alpha isoform 2 [Homo
sapiens]
Length = 490
Score = 577 bits (1487), Expect = e-165
Identities = 273/335 (81%), Positives = 308/335 (91%)
Query: 95 GYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVID 154
GYIPSYLDKDE CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHP+YSCKY+ CVID
Sbjct: 41 GYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVID 100
Query: 155 KVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEP 214
K+TRNQCQ CRFKKCI VGMA DLVLDDSKR+AKRKLIE+NRE+RR+EE+ +S+ +PEP
Sbjct: 101 KITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEP 160
Query: 215 TDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTK 274
T EEW+LI TEAH +TNAQGSHWKQ+RKFLP+DIGQ+PIV+ P+G KVDLEAFS FTK
Sbjct: 161 TPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTK 220
Query: 275 IITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEM 334
IITPAITRVVDFAKKLPMF ELPCEDQIILLKGCCMEIMSLRAAVRYDPES+TLTL+GEM
Sbjct: 221 IITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEM 280
Query: 335 AVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEK 394
AV R QLKNGGLGVVSDAIF+LG SLS+FNLDDTEVALLQAVLLMS+DR GL CV++IEK
Sbjct: 281 AVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEK 340
Query: 395 YQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLR 429
Q+++LLAFEHY+N+RKH++ HFWPKLLMK +++
Sbjct: 341 SQEAYLLAFEHYVNHRKHNIPHFWPKLLMKEREVQ 375
>gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 238 bits (608), Expect = 7e-63
Identities = 139/393 (35%), Positives = 208/393 (52%), Gaps = 32/393 (8%)
Query: 75 VNDQSVSSAQTFQTEEKKCKGYIPSYLDKDEL------CVVCGDKATGYHYRCITCEGCK 128
V+ S S T +T+ + +PS L C VC DK++GYHY CEGCK
Sbjct: 50 VSGYSTPSPATIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCK 109
Query: 129 GFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAK 188
GFFRR+IQKN+ Y+C + C+I+KVTRN+CQ CR +KC VGM+ + V +D
Sbjct: 110 GFFRRSIQKNM--VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRND------ 161
Query: 189 RKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPE 248
R K+++E + T E ELI+ V +AH T Q K+
Sbjct: 162 -------RNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALC---QLGKYTTN 211
Query: 249 DIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGC 308
+ + + +D++ + F+++ T I + V+FAK+LP F L DQI LLK
Sbjct: 212 NSSEQRV-------SLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAA 264
Query: 309 CMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDT 368
C++I+ LR RY PE +T+T + + + R Q+ N G G ++D +F L +DD
Sbjct: 265 CLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDA 324
Query: 369 EVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDL 428
E LL A+ L+ DR L +R++ Q+ L A + Y+ R+ H +PK+LMK+TDL
Sbjct: 325 ETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDL 384
Query: 429 RMIGACHASRFLHMKVECPTELFPPLFLEVFED 461
R I A A R + +K+E P + PPL E+ E+
Sbjct: 385 RSISAKGAERVITLKMEIPGSM-PPLIQEMLEN 416
>gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 238 bits (608), Expect = 7e-63
Identities = 139/393 (35%), Positives = 208/393 (52%), Gaps = 32/393 (8%)
Query: 75 VNDQSVSSAQTFQTEEKKCKGYIPSYLDKDEL------CVVCGDKATGYHYRCITCEGCK 128
V+ S S T +T+ + +PS L C VC DK++GYHY CEGCK
Sbjct: 50 VSGYSTPSPATIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCK 109
Query: 129 GFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAK 188
GFFRR+IQKN+ Y+C + C+I+KVTRN+CQ CR +KC VGM+ + V +D
Sbjct: 110 GFFRRSIQKNM--VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRND------ 161
Query: 189 RKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPE 248
R K+++E + T E ELI+ V +AH T Q K+
Sbjct: 162 -------RNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALC---QLGKYTTN 211
Query: 249 DIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGC 308
+ + + +D++ + F+++ T I + V+FAK+LP F L DQI LLK
Sbjct: 212 NSSEQRV-------SLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAA 264
Query: 309 CMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDT 368
C++I+ LR RY PE +T+T + + + R Q+ N G G ++D +F L +DD
Sbjct: 265 CLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDA 324
Query: 369 EVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDL 428
E LL A+ L+ DR L +R++ Q+ L A + Y+ R+ H +PK+LMK+TDL
Sbjct: 325 ETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDL 384
Query: 429 RMIGACHASRFLHMKVECPTELFPPLFLEVFED 461
R I A A R + +K+E P + PPL E+ E+
Sbjct: 385 RSISAKGAERVITLKMEIPGSM-PPLIQEMLEN 416
>gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens]
Length = 448
Score = 237 bits (605), Expect = 1e-62
Identities = 139/386 (36%), Positives = 209/386 (54%), Gaps = 32/386 (8%)
Query: 82 SAQTFQTEEKKCKGYIPSYLDK------DELCVVCGDKATGYHYRCITCEGCKGFFRRTI 135
+AQ+ +T+ + +PS + C VC DK++GYHY CEGCKGFFRR+I
Sbjct: 50 TAQSIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSI 109
Query: 136 QKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEEN 195
QKN+ Y+C + CVI+KVTRN+CQ CR +KC VGM+ + V +D
Sbjct: 110 QKNM--IYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRND------------- 154
Query: 196 REKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPI 255
R K+++E ++ E T E +L + + +AH T Q K+
Sbjct: 155 RNKKKKETSKQECTESYEMTAELDDLTEKIRKAHQETFPSLC---QLGKYTTNS------ 205
Query: 256 VNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSL 315
+A ++DL + F+++ T I ++V+FAK+LP F L DQI LLK C++I+ L
Sbjct: 206 -SADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILIL 264
Query: 316 RAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQA 375
R RY PE +T+T + + + R Q+ N G G ++D +F L +DDTE LL A
Sbjct: 265 RICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSA 324
Query: 376 VLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACH 435
+ L+ DR L +++K Q+ L A + YI R+ H +PK+LMK+TDLR I A
Sbjct: 325 ICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKG 384
Query: 436 ASRFLHMKVECPTELFPPLFLEVFED 461
A R + +K+E P + PPL E+ E+
Sbjct: 385 AERVITLKMEIPGSM-PPLIQEMLEN 409
>gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens]
Length = 457
Score = 234 bits (598), Expect = 9e-62
Identities = 136/386 (35%), Positives = 205/386 (53%), Gaps = 32/386 (8%)
Query: 82 SAQTFQTEEKKCKGYIPSYLDKDEL------CVVCGDKATGYHYRCITCEGCKGFFRRTI 135
S + +T+ + +PS L C VC DK++GYHY CEGCKGFFRR+I
Sbjct: 52 SNHSIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSI 111
Query: 136 QKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEEN 195
QKN+ Y+C + C+I+KVTRN+CQ CR +KC VGM+ + V +D
Sbjct: 112 QKNM--VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRND------------- 156
Query: 196 REKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPI 255
R K+++E + T E ELI+ V +AH T Q K+ + + +
Sbjct: 157 RNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALC---QLGKYTTNNSSEQRV 213
Query: 256 VNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSL 315
+D++ + F+++ T I + V+FAK+LP F L DQI LLK C++I+ L
Sbjct: 214 -------SLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILIL 266
Query: 316 RAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQA 375
R RY PE +T+T + + + R Q+ N G G ++D +F L +DD E LL A
Sbjct: 267 RICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSA 326
Query: 376 VLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACH 435
+ L+ DR L +R++ Q+ L A + Y+ R+ H +PK+LMK+TDLR I A
Sbjct: 327 ICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKG 386
Query: 436 ASRFLHMKVECPTELFPPLFLEVFED 461
A R + +K+E P + PPL E+ E+
Sbjct: 387 AERVITLKMEIPGSM-PPLIQEMLEN 411
>gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens]
Length = 443
Score = 231 bits (590), Expect = 8e-61
Identities = 136/387 (35%), Positives = 209/387 (54%), Gaps = 32/387 (8%)
Query: 81 SSAQTFQTEEKKCKGYIPSYLDKD------ELCVVCGDKATGYHYRCITCEGCKGFFRRT 134
+S Q+ +T+ + +PS + C VC DK++GYHY +CEGCKGFFRR+
Sbjct: 47 ASLQSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRS 106
Query: 135 IQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEE 194
IQKN+ Y+C + C+I+KVTRN+CQ CR +KC VGM+ + V +D
Sbjct: 107 IQKNM--VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRND------------ 152
Query: 195 NREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAP 254
R K+++E ++ E + + ELI V++AH T Q K+
Sbjct: 153 -RNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLC---QLGKYTTNS----- 203
Query: 255 IVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMS 314
+A ++DL + F+++ T I ++V+FAK+LP F L DQI LLK C++I+
Sbjct: 204 --SADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILM 261
Query: 315 LRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQ 374
LR RY PE +T+T + + + R Q+ N G G ++D +F L +DDTE LL
Sbjct: 262 LRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLS 321
Query: 375 AVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGAC 434
A+ L+ DR L E+++K Q+ L A Y R+ + +P++LMK+TDLR I
Sbjct: 322 AICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTK 381
Query: 435 HASRFLHMKVECPTELFPPLFLEVFED 461
A R + +K+E P + PPL E+ E+
Sbjct: 382 GAERAITLKMEIPGPM-PPLIREMLEN 407
>gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens]
Length = 454
Score = 231 bits (588), Expect = 1e-60
Identities = 131/355 (36%), Positives = 197/355 (55%), Gaps = 26/355 (7%)
Query: 107 CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRF 166
C VC DK++GYHY +CEGCKGFFRR+IQKN+ Y+C + C+I+KVTRN+CQ CR
Sbjct: 90 CFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNM--VYTCHRDKNCIINKVTRNRCQYCRL 147
Query: 167 KKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVT 226
+KC VGM+ + V +D R K+++E ++ E + + ELI V+
Sbjct: 148 QKCFEVGMSKEAVRND-------------RNKKKKEVKEEGSPDSYELSPQLEELITKVS 194
Query: 227 EAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDF 286
+AH T Q K+ +A ++DL + F+++ T I ++V+F
Sbjct: 195 KAHQETFPSLC---QLGKYTTNS-------SADHRVQLDLGLWDKFSELATKCIIKIVEF 244
Query: 287 AKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGL 346
AK+LP F L DQI LLK C++I+ LR RY PE +T+T + + + R Q+ N G
Sbjct: 245 AKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGF 304
Query: 347 GVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHY 406
G ++D +F L +DDTE LL A+ L+ DR L E+++K Q+ L A Y
Sbjct: 305 GPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLY 364
Query: 407 INYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED 461
R+ + +P++LMK+TDLR I A R + +K+E P + PPL E+ E+
Sbjct: 365 ARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPM-PPLIREMLEN 418
>gi|194294519 nuclear receptor subfamily 1, group H, member 3
isoform c [Homo sapiens]
Length = 402
Score = 209 bits (531), Expect = 6e-54
Identities = 123/375 (32%), Positives = 204/375 (54%), Gaps = 16/375 (4%)
Query: 90 EKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEG 149
+K+ KG P L +ELC VCGDKA+G+HY ++CEGCKGFFRR++ K H Y C G
Sbjct: 37 QKRKKGPAPKMLG-NELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAH--YICHSGG 93
Query: 150 KCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSK-RLAKRKLIEENREKRRREELQKSI 208
C +D R +CQECR +KC GM + VL + + RL K K EE + + S
Sbjct: 94 HCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASS 153
Query: 209 GHK--PEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDL 266
+ P+ + E+ +I+ + A N + + + + P P+ P +
Sbjct: 154 PPQILPQLSPEQLGMIEKLVAAQQQCNRRS--FSDRLRVTPW-----PMAPDPHSREARQ 206
Query: 267 EAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESE 326
+ F+HFT++ ++ +VDFAK+LP F +L EDQI LLK +E+M L + RY+P SE
Sbjct: 207 QRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSE 266
Query: 327 TLTLNGEMAVTRGQLKNGGLGV-VSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPG 385
++T + + R GL V + IF+ +++ L+D E ALL A+ + S+DRP
Sbjct: 267 SITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPN 326
Query: 386 LACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVE 445
+ ++E+ Q +++ A Y++ H +P++LMK+ LR + + H+ + ++++
Sbjct: 327 VQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQ 386
Query: 446 CPTELFPPLFLEVFE 460
+ PPL E+++
Sbjct: 387 --DKKLPPLLSEIWD 399
>gi|194294517 nuclear receptor subfamily 1, group H, member 3
isoform a [Homo sapiens]
Length = 447
Score = 209 bits (531), Expect = 6e-54
Identities = 123/375 (32%), Positives = 204/375 (54%), Gaps = 16/375 (4%)
Query: 90 EKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEG 149
+K+ KG P L +ELC VCGDKA+G+HY ++CEGCKGFFRR++ K H Y C G
Sbjct: 82 QKRKKGPAPKMLG-NELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAH--YICHSGG 138
Query: 150 KCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSK-RLAKRKLIEENREKRRREELQKSI 208
C +D R +CQECR +KC GM + VL + + RL K K EE + + S
Sbjct: 139 HCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASS 198
Query: 209 GHK--PEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDL 266
+ P+ + E+ +I+ + A N + + + + P P+ P +
Sbjct: 199 PPQILPQLSPEQLGMIEKLVAAQQQCNRRS--FSDRLRVTPW-----PMAPDPHSREARQ 251
Query: 267 EAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESE 326
+ F+HFT++ ++ +VDFAK+LP F +L EDQI LLK +E+M L + RY+P SE
Sbjct: 252 QRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSE 311
Query: 327 TLTLNGEMAVTRGQLKNGGLGV-VSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPG 385
++T + + R GL V + IF+ +++ L+D E ALL A+ + S+DRP
Sbjct: 312 SITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPN 371
Query: 386 LACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVE 445
+ ++E+ Q +++ A Y++ H +P++LMK+ LR + + H+ + ++++
Sbjct: 372 VQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQ 431
Query: 446 CPTELFPPLFLEVFE 460
+ PPL E+++
Sbjct: 432 --DKKLPPLLSEIWD 444
>gi|85362735 nuclear receptor subfamily 1, group H, member 2 [Homo
sapiens]
Length = 461
Score = 194 bits (492), Expect = 2e-49
Identities = 117/396 (29%), Positives = 198/396 (50%), Gaps = 27/396 (6%)
Query: 87 QTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCK 146
+ E K+ KG P L ELC VCGDKA+G+HY ++CEGCKGFFRR++ + Y+C+
Sbjct: 68 EPERKRKKGPAPKMLGH-ELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACR 126
Query: 147 YEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQK 206
G C +D R +CQ+CR +KC GM VL + + ++K I + +++ + + Q
Sbjct: 127 GGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQ--IRKKKIRKQQQQESQSQSQS 184
Query: 207 SIGHKPEPT--------------------DEEWELIKTVTEAHVATNAQGSHWKQKRKFL 246
+G + + + E + E + KR F
Sbjct: 185 PVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFS 244
Query: 247 PED-IGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILL 305
+ + P+ P+ + F+HFT++ ++ +VDFAK++P F +L EDQI LL
Sbjct: 245 DQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALL 304
Query: 306 KGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGV-VSDAIFDLGMSLSSFN 364
K +EIM L A RY+ E+E +T + ++ GL V + IF+ ++
Sbjct: 305 KASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLG 364
Query: 365 LDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMK 424
LDD E ALL A+ + S+DRP + R+E Q ++ A Y ++ +P++LMK
Sbjct: 365 LDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMK 424
Query: 425 VTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFE 460
+ LR + + H+ + ++++ + PPL E+++
Sbjct: 425 LVSLRTLSSVHSEQVFALRLQ--DKKLPPLLSEIWD 458
>gi|7706625 retinoic acid receptor, beta isoform 2 [Homo sapiens]
Length = 336
Score = 189 bits (479), Expect = 6e-48
Identities = 111/319 (34%), Positives = 170/319 (53%), Gaps = 24/319 (7%)
Query: 143 YSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRRE 202
Y+C + CVI+KVTRN+CQ CR +KC VGM+ + V +D R K+++E
Sbjct: 3 YTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRND-------------RNKKKKE 49
Query: 203 ELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGG 262
++ E T E +L + + +AH T Q K+ +A
Sbjct: 50 TSKQECTESYEMTAELDDLTEKIRKAHQETFPSLC---QLGKYTTNS-------SADHRV 99
Query: 263 KVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYD 322
++DL + F+++ T I ++V+FAK+LP F L DQI LLK C++I+ LR RY
Sbjct: 100 RLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYT 159
Query: 323 PESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSD 382
PE +T+T + + + R Q+ N G G ++D +F L +DDTE LL A+ L+ D
Sbjct: 160 PEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGD 219
Query: 383 RPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHM 442
R L +++K Q+ L A + YI R+ H +PK+LMK+TDLR I A A R + +
Sbjct: 220 RQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITL 279
Query: 443 KVECPTELFPPLFLEVFED 461
K+E P + PPL E+ E+
Sbjct: 280 KMEIPGSM-PPLIQEMLEN 297
>gi|4826980 nuclear receptor subfamily 1, group H, member 4 [Homo
sapiens]
Length = 472
Score = 173 bits (439), Expect = 3e-43
Identities = 120/371 (32%), Positives = 179/371 (48%), Gaps = 38/371 (10%)
Query: 104 DELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQE 163
DELCVVCGD+A+GYHY +TCEGCKGFFRR+I KN Y CK G CV+D R +CQE
Sbjct: 124 DELCVVCGDRASGYHYNALTCEGCKGFFRRSITKN--AVYKCKNGGNCVMDMYMRRKCQE 181
Query: 164 CRFKKCIYVGMATDLVLDD----SKRLAKR---------KLIEENREKRRREELQKSIGH 210
CR +KC +GM + +L + SKRL K E R+ R+ KS
Sbjct: 182 CRLRKCKEMGMLAECLLTEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTTKSCRE 241
Query: 211 KPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFS 270
K E T ++ L+ + +++ N Q + K L E+ E F
Sbjct: 242 KTELTPDQQTLLHFIMDSY---NKQRMPQEITNKILKEEFSAE-------------ENFL 285
Query: 271 HFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTL 330
T++ T + +V+F KKLP F L EDQI LLKG +E M LR+A ++ +
Sbjct: 286 ILTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLP---- 341
Query: 331 NGEMAVTRGQLKNGGLG-VVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACV 389
+G + +++N G+ +F S+ + E ALL A++++S DR +
Sbjct: 342 SGHSDLLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDR 401
Query: 390 ERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTE 449
E +EK Q+ L + + + LL ++T+LR HA + +V
Sbjct: 402 EAVEKLQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVN--DH 459
Query: 450 LFPPLFLEVFE 460
F PL E+++
Sbjct: 460 KFTPLLCEIWD 470
>gi|14702164 nuclear receptor subfamily 1, group I, member 2 isoform
3 [Homo sapiens]
Length = 397
Score = 172 bits (436), Expect = 6e-43
Identities = 113/363 (31%), Positives = 178/363 (49%), Gaps = 17/363 (4%)
Query: 105 ELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKY-EGKCVIDKVTRNQCQE 163
++C VCGDKATGYH+ +TCEGCKGFFRR +++N C + +G C I + TR QCQ
Sbjct: 39 QICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNAR--LRCPFRKGACEITRKTRRQCQA 96
Query: 164 CRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIK 223
CR +KC+ GM ++++ D +R LI+ + +R + G T+E+ +I+
Sbjct: 97 CRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQG----LTEEQRMMIR 152
Query: 224 TVTEAHVAT-NAQGSHWKQKRKFLPEDIGQAPIVN----APEGGKVDLEAFSHFTKIITP 278
+ +A + T + SH+K R L + N A GGK H + T
Sbjct: 153 ELMDAQMKTFDTTFSHFKNFRVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTY 212
Query: 279 AITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTR 338
++ FAK + F +LP EDQI LLKG E+ LR ++ E+ T G ++
Sbjct: 213 MFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWEC-GRLSYCL 271
Query: 339 GQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDS 398
G ++ + + L L + E L+QA+ L S DRPG+ +++ Q+
Sbjct: 272 EDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQ 331
Query: 399 FLLAFEHYINYRKHHVTH--FWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFL 456
F + + YI + H + K++ +T+LR I A H R L ++ P PL
Sbjct: 332 FAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHP--FATPLMQ 389
Query: 457 EVF 459
E+F
Sbjct: 390 ELF 392
>gi|4826661 constitutive androstane receptor isoform 3 [Homo
sapiens]
Length = 348
Score = 169 bits (429), Expect = 4e-42
Identities = 116/350 (33%), Positives = 174/350 (49%), Gaps = 29/350 (8%)
Query: 103 KDEL--CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQ 160
+DEL CVVCGD+ATGYH+ +TCEGCKGFFRRT+ K++ P +C + G C + K R
Sbjct: 5 EDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGP--TCPFAGSCEVSKTQRRH 62
Query: 161 CQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWE 220
C CR +KC+ GM D++L +R + R ++ +L K E+ E
Sbjct: 63 CPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSK----------EQEE 112
Query: 221 LIKTVTEAHVATNAQGSHWKQKRKFLPED---IGQAPIVN-APEGGKVDLEAFSHFTKII 276
LI+T+ AH T G+ ++Q +F P I P+ AP L +HF I
Sbjct: 113 LIRTLLGAH--TRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPV-----LPLVTHFADIN 165
Query: 277 TPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAV 336
T + +V+ F K LP+F LP EDQI LLKG +EI + + +++ L G +
Sbjct: 166 TFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNF-LCGPLRY 224
Query: 337 TRGQLKNGGLGV-VSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKY 395
T G V + +F +L L + E LL A+ L S DRPG+ + I++
Sbjct: 225 TIEDGARVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGVTQRDEIDQL 284
Query: 396 QDSFLLAFEHYI--NYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMK 443
Q+ L + YI R+ + KLL + +LR I + + H++
Sbjct: 285 QEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQ 334
>gi|117938752 constitutive androstane receptor isoform 2 [Homo
sapiens]
Length = 352
Score = 166 bits (421), Expect = 3e-41
Identities = 116/354 (32%), Positives = 174/354 (49%), Gaps = 33/354 (9%)
Query: 103 KDEL--CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQ 160
+DEL CVVCGD+ATGYH+ +TCEGCKGFFRRT+ K++ P +C + G C + K R
Sbjct: 5 EDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGP--TCPFAGSCEVSKTQRRH 62
Query: 161 CQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWE 220
C CR +KC+ GM D++L +R + R ++ +L K E+ E
Sbjct: 63 CPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSK----------EQEE 112
Query: 221 LIKTVTEAHVATNAQGSHWKQKRKFLPED---IGQAPIVN-APEGGKVDLEAFSHFTKII 276
LI+T+ AH T G+ ++Q +F P I P+ AP L +HF I
Sbjct: 113 LIRTLLGAH--TRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPV-----LPLVTHFADIN 165
Query: 277 TPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAV 336
T + +V+ F K LP+F LP EDQI LLKG +EI + + +++ L G +
Sbjct: 166 TFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNF-LCGPLRY 224
Query: 337 T-----RGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVER 391
T R G + +F +L L + E LL A+ L S DRPG+ +
Sbjct: 225 TIEDGARVSPTVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGVTQRDE 284
Query: 392 IEKYQDSFLLAFEHYI--NYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMK 443
I++ Q+ L + YI R+ + KLL + +LR I + + H++
Sbjct: 285 IDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQ 338
>gi|117938756 constitutive androstane receptor isoform 1 [Homo
sapiens]
Length = 357
Score = 161 bits (407), Expect = 1e-39
Identities = 116/359 (32%), Positives = 175/359 (48%), Gaps = 38/359 (10%)
Query: 103 KDEL--CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQ 160
+DEL CVVCGD+ATGYH+ +TCEGCKGFFRRT+ K++ P +C + G C + K R
Sbjct: 5 EDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGP--TCPFAGSCEVSKTQRRH 62
Query: 161 CQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWE 220
C CR +KC+ GM D++L +R + R ++ +L K E+ E
Sbjct: 63 CPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSK----------EQEE 112
Query: 221 LIKTVTEAHVATNAQGSHWKQKRKFLPED---IGQAPIVN-APEGGKVDLEAFSHFTKII 276
LI+T+ AH T G+ ++Q +F P I P+ AP L +HF I
Sbjct: 113 LIRTLLGAH--TRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPV-----LPLVTHFADIN 165
Query: 277 TPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAV 336
T + +V+ F K LP+F LP EDQI LLKG +EI + + +++ L G +
Sbjct: 166 TFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNF-LCGPLRY 224
Query: 337 T-----RGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMS-----SDRPGL 386
T R G + +F +L L + E LL A+ L S +DRPG+
Sbjct: 225 TIEDGARVSPTVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPAPYLTDRPGV 284
Query: 387 ACVERIEKYQDSFLLAFEHYI--NYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMK 443
+ I++ Q+ L + YI R+ + KLL + +LR I + + H++
Sbjct: 285 TQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQ 343
>gi|63054845 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo
sapiens]
Length = 427
Score = 160 bits (406), Expect = 2e-39
Identities = 115/410 (28%), Positives = 195/410 (47%), Gaps = 66/410 (16%)
Query: 106 LCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECR 165
+C VCGD+ATG+H+ +TCEGCKGFFRR++++ ++C + G C I K R CQ CR
Sbjct: 23 ICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRK--ALFTCPFNGDCRITKDNRRHCQACR 80
Query: 166 FKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTV 225
K+C+ +GM + +L D + KR++I + +E+ E L+ S+ +P+ ++E+ +I +
Sbjct: 81 LKRCVDIGMMKEFILTDEEVQRKREMILKRKEE---EALKDSL--RPKLSEEQQRIIAIL 135
Query: 226 TEAHVAT------------------NAQGSH-WKQKRKFLPEDIG------------QAP 254
+AH T + GSH + + P G +
Sbjct: 136 LDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSD 195
Query: 255 IVNAPEGGKVD-----------------LEAFSHFTKIITPAITRVVDFAKKLPMFCELP 297
++++ +D L H +++ +I +V+ FAK +P F +L
Sbjct: 196 MMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLT 255
Query: 298 CEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTR--GQLKNGGLGVVSDAIFD 355
EDQI+LLK +E++ LR+ + + + T + R K G + + +
Sbjct: 256 SEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIK 315
Query: 356 LGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRK---- 411
+ L NL + E LL A+ ++S DRPG+ IE QD + YI R
Sbjct: 316 FQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPG 375
Query: 412 HHVTHFWPKLLMKVTDLRMIGACHASRF--LHMKVECPTELFPPLFLEVF 459
H+ + K++ K+ DLR + H+ ++ L + EC +L PL LEVF
Sbjct: 376 SHL--LYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKL-TPLVLEVF 422
>gi|4507883 vitamin D (1,25-dihydroxyvitamin D3) receptor [Homo
sapiens]
Length = 427
Score = 160 bits (406), Expect = 2e-39
Identities = 115/410 (28%), Positives = 195/410 (47%), Gaps = 66/410 (16%)
Query: 106 LCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECR 165
+C VCGD+ATG+H+ +TCEGCKGFFRR++++ ++C + G C I K R CQ CR
Sbjct: 23 ICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRK--ALFTCPFNGDCRITKDNRRHCQACR 80
Query: 166 FKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTV 225
K+C+ +GM + +L D + KR++I + +E+ E L+ S+ +P+ ++E+ +I +
Sbjct: 81 LKRCVDIGMMKEFILTDEEVQRKREMILKRKEE---EALKDSL--RPKLSEEQQRIIAIL 135
Query: 226 TEAHVAT------------------NAQGSH-WKQKRKFLPEDIG------------QAP 254
+AH T + GSH + + P G +
Sbjct: 136 LDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSD 195
Query: 255 IVNAPEGGKVD-----------------LEAFSHFTKIITPAITRVVDFAKKLPMFCELP 297
++++ +D L H +++ +I +V+ FAK +P F +L
Sbjct: 196 MMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLT 255
Query: 298 CEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTR--GQLKNGGLGVVSDAIFD 355
EDQI+LLK +E++ LR+ + + + T + R K G + + +
Sbjct: 256 SEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIK 315
Query: 356 LGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRK---- 411
+ L NL + E LL A+ ++S DRPG+ IE QD + YI R
Sbjct: 316 FQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPG 375
Query: 412 HHVTHFWPKLLMKVTDLRMIGACHASRF--LHMKVECPTELFPPLFLEVF 459
H+ + K++ K+ DLR + H+ ++ L + EC +L PL LEVF
Sbjct: 376 SHL--LYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKL-TPLVLEVF 422
>gi|117938746 constitutive androstane receptor isoform 7 [Homo
sapiens]
Length = 339
Score = 159 bits (403), Expect = 4e-39
Identities = 108/316 (34%), Positives = 158/316 (50%), Gaps = 31/316 (9%)
Query: 103 KDEL--CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQ 160
+DEL CVVCGD+ATGYH+ +TCEGCKGFFRRT+ K++ P +C + G C + K R
Sbjct: 5 EDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGP--TCPFAGSCEVSKTQRRH 62
Query: 161 CQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWE 220
C CR +KC+ GM D++L +R + R ++ +L K E+ E
Sbjct: 63 CPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSK----------EQEE 112
Query: 221 LIKTVTEAHVATNAQGSHWKQKRKFLPED---IGQAPIVN-APEGGKVDLEAFSHFTKII 276
LI+T+ AH T G+ ++Q +F P I P+ AP L +HF I
Sbjct: 113 LIRTLLGAH--TRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPV-----LPLVTHFADIN 165
Query: 277 TPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAV 336
T + +V+ F K LP+F LP EDQI LLKG +EI + + +++ L G +
Sbjct: 166 TFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNF-LCGPLRY 224
Query: 337 T-----RGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVER 391
T R G + +F +L L + E LL A+ L S DRPG+ +
Sbjct: 225 TIEDGARVSPTVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGVTQRDE 284
Query: 392 IEKYQDSFLLAFEHYI 407
I++ Q+ L + YI
Sbjct: 285 IDQLQEEMALTLQSYI 300
>gi|117938729 constitutive androstane receptor isoform 6 [Homo
sapiens]
Length = 340
Score = 157 bits (397), Expect = 2e-38
Identities = 108/317 (34%), Positives = 159/317 (50%), Gaps = 32/317 (10%)
Query: 103 KDEL--CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQ 160
+DEL CVVCGD+ATGYH+ +TCEGCKGFFRRT+ K++ P +C + G C + K R
Sbjct: 5 EDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGP--TCPFAGSCEVSKTQRRH 62
Query: 161 CQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWE 220
C CR +KC+ GM D++L +R + R ++ +L K E+ E
Sbjct: 63 CPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSK----------EQEE 112
Query: 221 LIKTVTEAHVATNAQGSHWKQKRKFLPED---IGQAPIVN-APEGGKVDLEAFSHFTKII 276
LI+T+ AH T G+ ++Q +F P I P+ AP L +HF I
Sbjct: 113 LIRTLLGAH--TRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPV-----LPLVTHFADIN 165
Query: 277 TPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAV 336
T + +V+ F K LP+F LP EDQI LLKG +EI + + +++ L G +
Sbjct: 166 TFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNF-LCGPLRY 224
Query: 337 TRGQLKNGGLGV-VSDAIFDLGMSLSSFNLDDTEVALLQAVLLMS-----SDRPGLACVE 390
T G V + +F +L L + E LL A+ L S +DRPG+ +
Sbjct: 225 TIEDGARVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPAPYLTDRPGVTQRD 284
Query: 391 RIEKYQDSFLLAFEHYI 407
I++ Q+ L + YI
Sbjct: 285 EIDQLQEEMALTLQSYI 301
>gi|5453940 peroxisome proliferative activated receptor, delta
isoform 1 [Homo sapiens]
Length = 441
Score = 152 bits (384), Expect = 6e-37
Identities = 116/374 (31%), Positives = 178/374 (47%), Gaps = 27/374 (7%)
Query: 107 CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRF 166
C VCGDKA+G+HY CEGCKGFFRRTI+ L K E C I K RN+CQ CRF
Sbjct: 74 CRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYE---KCERSCKIQKKNRNKCQYCRF 130
Query: 167 KKCIYVGMATDLV-LDDSKRLAKRKLI------EENREKRRREELQKSIGHKPEPTDEEW 219
+KC+ +GM+ + + KRKL+ E ++ + +L+ H + +
Sbjct: 131 QKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNF 190
Query: 220 ELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAP-------IVNA-PEGGKVDLEAFSH 271
+ K +A + SH E + QA +VN P ++ + F
Sbjct: 191 NMTKK--KARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYR 248
Query: 272 FTKIITPAITRVVDFAKKLPMFCELPCEDQIILLK-GCCMEIMSLRAAVRYDPESETLTL 330
+ + +FAK +P F L DQ+ LLK G I ++ A++ + L
Sbjct: 249 CQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVN--KDGLLVA 306
Query: 331 NGEMAVTRGQLKN--GGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLAC 388
NG VTR L++ + + F+ + ++ LDD+++AL A +++ DRPGL
Sbjct: 307 NGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMN 366
Query: 389 VERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHM-KVECP 447
V R+E QD+ L A E ++ + +PKLL K+ DLR + HA + K E
Sbjct: 367 VPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETE 426
Query: 448 TELFPPLFLEVFED 461
T L PL E+++D
Sbjct: 427 TSLH-PLLQEIYKD 439
>gi|223718070 retinoic acid receptor, alpha isoform 4 [Homo sapiens]
Length = 365
Score = 150 bits (380), Expect = 2e-36
Identities = 88/270 (32%), Positives = 141/270 (52%), Gaps = 11/270 (4%)
Query: 192 IEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIG 251
+ +R K+++E + T E ELI+ V +AH T Q K+ +
Sbjct: 61 VRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALC---QLGKYTTNNSS 117
Query: 252 QAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCME 311
+ + +D++ + F+++ T I + V+FAK+LP F L DQI LLK C++
Sbjct: 118 EQRV-------SLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLD 170
Query: 312 IMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVA 371
I+ LR RY PE +T+T + + + R Q+ N G G ++D +F L +DD E
Sbjct: 171 ILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETG 230
Query: 372 LLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMI 431
LL A+ L+ DR L +R++ Q+ L A + Y+ R+ H +PK+LMK+TDLR I
Sbjct: 231 LLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSI 290
Query: 432 GACHASRFLHMKVECPTELFPPLFLEVFED 461
A A R + +K+E P + PPL E+ E+
Sbjct: 291 SAKGAERVITLKMEIPGSM-PPLIQEMLEN 319
>gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo
sapiens]
Length = 598
Score = 150 bits (379), Expect = 2e-36
Identities = 103/350 (29%), Positives = 168/350 (48%), Gaps = 29/350 (8%)
Query: 106 LCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECR 165
LC VCGD A HY TCEGCKGFF+RT+QKN Y C C +DK RN+CQ CR
Sbjct: 262 LCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKN--AKYVCLANKNCPVDKRRRNRCQYCR 319
Query: 166 FKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTV 225
F+KC+ VGM ++V DS + + +L + + + +P P LI +
Sbjct: 320 FQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKSPQ-----------EPSPPSPPVSLISAL 368
Query: 226 TEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVD 285
AHV +N + R D + D + F ++T ++ +
Sbjct: 369 VRAHVDSNPAMTSLDYSRFQANPDY---------QMSGDDTQHIQQFYDLLTGSMEIIRG 419
Query: 286 FAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGG 345
+A+K+P F +LP DQ +L + +E+ LR A R +P L + + R Q G
Sbjct: 420 WAEKIPGFADLPKADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVR-G 478
Query: 346 LGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEH 405
G D+I + +L + N+D + + + A L M ++R GL +R+E+ Q+ + +
Sbjct: 479 FGEWIDSIVEFSSNLQNMNIDISAFSCI-AALAMVTERHGLKEPKRVEELQNKIVNCLKD 537
Query: 406 YINYRKHHVT--HFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPP 453
++ + + ++ KLL K+ +LR + R ++K+E +L PP
Sbjct: 538 HVTFNNGGLNRPNYLSKLLGKLPELRTLCTQGLQRIFYLKLE---DLVPP 584
>gi|4506755 retinoid X receptor, alpha [Homo sapiens]
Length = 462
Score = 148 bits (374), Expect = 9e-36
Identities = 89/328 (27%), Positives = 165/328 (50%), Gaps = 33/328 (10%)
Query: 106 LCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECR 165
+C +CGD+++G HY +CEGCKGFF+RT++K+L +Y+C+ C+IDK RN+CQ CR
Sbjct: 134 ICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDL--TYTCRDNKDCLIDKRQRNRCQYCR 191
Query: 166 FKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTV 225
++KC+ +GM + V ++ +R +++ E S ++ P ++ +
Sbjct: 192 YQKCLAMGMKREAVQEERQR---------GKDRNENEVESTSSANEDMP-------VERI 235
Query: 226 TEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVD 285
EA +A + + + L P+ N + D + F+ +V+
Sbjct: 236 LEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQA--ADKQLFT------------LVE 281
Query: 286 FAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGG 345
+AK++P F ELP +DQ+ILL+ E++ + R + + L + V R + G
Sbjct: 282 WAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAG 341
Query: 346 LGVVSDAIF-DLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFE 404
+G + D + +L + +D TE+ L+A++L + D GL+ +E ++ + E
Sbjct: 342 VGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLE 401
Query: 405 HYINYRKHHVTHFWPKLLMKVTDLRMIG 432
Y ++ + KLL+++ LR IG
Sbjct: 402 AYCKHKYPEQPGRFAKLLLRLPALRSIG 429
>gi|117938754 constitutive androstane receptor isoform 4 [Homo
sapiens]
Length = 314
Score = 145 bits (366), Expect = 8e-35
Identities = 110/349 (31%), Positives = 162/349 (46%), Gaps = 61/349 (17%)
Query: 103 KDEL--CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQ 160
+DEL CVVCGD+ATGYH+ +TCEGCKGFFRRT+ K++ P +C + G C + K R
Sbjct: 5 EDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGP--TCPFAGSCEVSKTQRRH 62
Query: 161 CQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWE 220
C CR +KC+ GM D++L +R + R ++ +L K E+ E
Sbjct: 63 CPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSK----------EQEE 112
Query: 221 LIKTVTEAHVATNAQGSHWKQKRKFLPED---IGQAPIVN-APEGGKVDLEAFSHFTKII 276
LI+T+ AH T G+ ++Q +F P I P+ AP L +HF I
Sbjct: 113 LIRTLLGAH--TRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPV-----LPLVTHFADIN 165
Query: 277 TPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAV 336
T + +V+ F K LP+F LP EDQI LLKG +EI + LN +
Sbjct: 166 TFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICH-------------IVLNTTFCL 212
Query: 337 TRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQ 396
Q +N G + I D A +DRPG+ + I++ Q
Sbjct: 213 ---QTQNFLCGPLRYTIED------------------GARAPYLTDRPGVTQRDEIDQLQ 251
Query: 397 DSFLLAFEHYI--NYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMK 443
+ L + YI R+ + KLL + +LR I + + H++
Sbjct: 252 EEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQ 300
>gi|117938734 constitutive androstane receptor isoform 5 [Homo
sapiens]
Length = 309
Score = 145 bits (366), Expect = 8e-35
Identities = 107/349 (30%), Positives = 160/349 (45%), Gaps = 66/349 (18%)
Query: 103 KDEL--CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQ 160
+DEL CVVCGD+ATGYH+ +TCEGCKGFFRRT+ K++ P +C + G C + K R
Sbjct: 5 EDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGP--TCPFAGSCEVSKTQRRH 62
Query: 161 CQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWE 220
C CR +KC+ GM D++L +R + R ++ +L K E+ E
Sbjct: 63 CPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSK----------EQEE 112
Query: 221 LIKTVTEAHVATNAQGSHWKQKRKFLPED---IGQAPIVN-APEGGKVDLEAFSHFTKII 276
LI+T+ AH T G+ ++Q +F P I P+ AP L +HF I
Sbjct: 113 LIRTLLGAH--TRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPV-----LPLVTHFADIN 165
Query: 277 TPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAV 336
T + +V+ F K LP+F LP EDQI LLKG +EI + LN +
Sbjct: 166 TFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICH-------------IVLNTTFCL 212
Query: 337 TRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQ 396
G L + ++D + DRPG+ + I++ Q
Sbjct: 213 QTQNFLCGPL---------------RYTIEDG-----------ARDRPGVTQRDEIDQLQ 246
Query: 397 DSFLLAFEHYI--NYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMK 443
+ L + YI R+ + KLL + +LR I + + H++
Sbjct: 247 EEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQ 295
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,378,710
Number of Sequences: 37866
Number of extensions: 844641
Number of successful extensions: 3078
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 129
Number of HSP's successfully gapped in prelim test: 28
Number of HSP's that attempted gapping in prelim test: 2644
Number of HSP's gapped (non-prelim): 253
length of query: 461
length of database: 18,247,518
effective HSP length: 106
effective length of query: 355
effective length of database: 14,233,722
effective search space: 5052971310
effective search space used: 5052971310
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.