Search of human proteins with 189458817

Search of human proteins with 189458817

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|189458817 transferrin receptor [Homo sapiens]
         (760 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|189458819 transferrin receptor [Homo sapiens]                     1531   0.0  
gi|189458817 transferrin receptor [Homo sapiens]                     1531   0.0  
gi|33589848 transferrin receptor 2 [Homo sapiens]                     563   e-160
gi|4758398 folate hydrolase 1 isoform 1 [Homo sapiens]                226   6e-59
gi|4885505 N-acetylated alpha-linked acidic dipeptidase 2 [Homo ...   217   4e-56
gi|57232740 N-acetylated alpha-linked acidic dipeptidase-like 1 ...   207   3e-53
gi|62548858 folate hydrolase 1 isoform 2 [Homo sapiens]               194   3e-49
gi|24308545 folate hydrolase 1B [Homo sapiens]                        156   6e-38
gi|126157508 N-acetylated alpha-linked acidic dipeptidase 2 [Hom...   125   2e-28
gi|7706387 plasma glutamate carboxypeptidase [Homo sapiens]            39   0.014
gi|51873031 nicalin [Homo sapiens]                                     39   0.018
gi|29788758 ring finger protein 130 [Homo sapiens]                     33   0.75 
gi|122937402 transmembrane protein 8C [Homo sapiens]                   33   0.99 
gi|66912176 leucine rich repeat containing 66 [Homo sapiens]           31   3.7  
gi|33286418 pyruvate kinase, muscle isoform M2 [Homo sapiens]          31   4.9  
gi|33286422 pyruvate kinase, muscle isoform M1 [Homo sapiens]          31   4.9  
gi|33286420 pyruvate kinase, muscle isoform M1 [Homo sapiens]          31   4.9  
gi|169218111 PREDICTED: similar to pyruvate kinase, muscle [Homo...    31   4.9  
gi|119120884 fer-1-like 6 [Homo sapiens]                               31   4.9  
gi|163310725 ER degradation enhancer, mannosidase alpha-like 3 [...    30   6.4  

>gi|189458819 transferrin receptor [Homo sapiens]
          Length = 760

 Score = 1531 bits (3964), Expect = 0.0
 Identities = 760/760 (100%), Positives = 760/760 (100%)

Query: 1   MMDQARSAFSNLFGGEPLSYTRFSLARQVDGDNSHVEMKLAVDEEENADNNTKANVTKPK 60
           MMDQARSAFSNLFGGEPLSYTRFSLARQVDGDNSHVEMKLAVDEEENADNNTKANVTKPK
Sbjct: 1   MMDQARSAFSNLFGGEPLSYTRFSLARQVDGDNSHVEMKLAVDEEENADNNTKANVTKPK 60

Query: 61  RCSGSICYGTIAVIVFFLIGFMIGYLGYCKGVEPKTECERLAGTESPVREEPGEDFPAAR 120
           RCSGSICYGTIAVIVFFLIGFMIGYLGYCKGVEPKTECERLAGTESPVREEPGEDFPAAR
Sbjct: 61  RCSGSICYGTIAVIVFFLIGFMIGYLGYCKGVEPKTECERLAGTESPVREEPGEDFPAAR 120

Query: 121 RLYWDDLKRKLSEKLDSTDFTGTIKLLNENSYVPREAGSQKDENLALYVENQFREFKLSK 180
           RLYWDDLKRKLSEKLDSTDFTGTIKLLNENSYVPREAGSQKDENLALYVENQFREFKLSK
Sbjct: 121 RLYWDDLKRKLSEKLDSTDFTGTIKLLNENSYVPREAGSQKDENLALYVENQFREFKLSK 180

Query: 181 VWRDQHFVKIQVKDSAQNSVIIVDKNGRLVYLVENPGGYVAYSKAATVTGKLVHANFGTK 240
           VWRDQHFVKIQVKDSAQNSVIIVDKNGRLVYLVENPGGYVAYSKAATVTGKLVHANFGTK
Sbjct: 181 VWRDQHFVKIQVKDSAQNSVIIVDKNGRLVYLVENPGGYVAYSKAATVTGKLVHANFGTK 240

Query: 241 KDFEDLYTPVNGSIVIVRAGKITFAEKVANAESLNAIGVLIYMDQTKFPIVNAELSFFGH 300
           KDFEDLYTPVNGSIVIVRAGKITFAEKVANAESLNAIGVLIYMDQTKFPIVNAELSFFGH
Sbjct: 241 KDFEDLYTPVNGSIVIVRAGKITFAEKVANAESLNAIGVLIYMDQTKFPIVNAELSFFGH 300

Query: 301 AHLGTGDPYTPGFPSFNHTQFPPSRSSGLPNIPVQTISRAAAEKLFGNMEGDCPSDWKTD 360
           AHLGTGDPYTPGFPSFNHTQFPPSRSSGLPNIPVQTISRAAAEKLFGNMEGDCPSDWKTD
Sbjct: 301 AHLGTGDPYTPGFPSFNHTQFPPSRSSGLPNIPVQTISRAAAEKLFGNMEGDCPSDWKTD 360

Query: 361 STCRMVTSESKNVKLTVSNVLKEIKILNIFGVIKGFVEPDHYVVVGAQRDAWGPGAAKSG 420
           STCRMVTSESKNVKLTVSNVLKEIKILNIFGVIKGFVEPDHYVVVGAQRDAWGPGAAKSG
Sbjct: 361 STCRMVTSESKNVKLTVSNVLKEIKILNIFGVIKGFVEPDHYVVVGAQRDAWGPGAAKSG 420

Query: 421 VGTALLLKLAQMFSDMVLKDGFQPSRSIIFASWSAGDFGSVGATEWLEGYLSSLHLKAFT 480
           VGTALLLKLAQMFSDMVLKDGFQPSRSIIFASWSAGDFGSVGATEWLEGYLSSLHLKAFT
Sbjct: 421 VGTALLLKLAQMFSDMVLKDGFQPSRSIIFASWSAGDFGSVGATEWLEGYLSSLHLKAFT 480

Query: 481 YINLDKAVLGTSNFKVSASPLLYTLIEKTMQNVKHPVTGQFLYQDSNWASKVEKLTLDNA 540
           YINLDKAVLGTSNFKVSASPLLYTLIEKTMQNVKHPVTGQFLYQDSNWASKVEKLTLDNA
Sbjct: 481 YINLDKAVLGTSNFKVSASPLLYTLIEKTMQNVKHPVTGQFLYQDSNWASKVEKLTLDNA 540

Query: 541 AFPFLAYSGIPAVSFCFCEDTDYPYLGTTMDTYKELIERIPELNKVARAAAEVAGQFVIK 600
           AFPFLAYSGIPAVSFCFCEDTDYPYLGTTMDTYKELIERIPELNKVARAAAEVAGQFVIK
Sbjct: 541 AFPFLAYSGIPAVSFCFCEDTDYPYLGTTMDTYKELIERIPELNKVARAAAEVAGQFVIK 600

Query: 601 LTHDVELNLDYERYNSQLLSFVRDLNQYRADIKEMGLSLQWLYSARGDFFRATSRLTTDF 660
           LTHDVELNLDYERYNSQLLSFVRDLNQYRADIKEMGLSLQWLYSARGDFFRATSRLTTDF
Sbjct: 601 LTHDVELNLDYERYNSQLLSFVRDLNQYRADIKEMGLSLQWLYSARGDFFRATSRLTTDF 660

Query: 661 GNAEKTDRFVMKKLNDRVMRVEYHFLSPYVSPKESPFRHVFWGSGSHTLPALLENLKLRK 720
           GNAEKTDRFVMKKLNDRVMRVEYHFLSPYVSPKESPFRHVFWGSGSHTLPALLENLKLRK
Sbjct: 661 GNAEKTDRFVMKKLNDRVMRVEYHFLSPYVSPKESPFRHVFWGSGSHTLPALLENLKLRK 720

Query: 721 QNNGAFNETLFRNQLALATWTIQGAANALSGDVWDIDNEF 760
           QNNGAFNETLFRNQLALATWTIQGAANALSGDVWDIDNEF
Sbjct: 721 QNNGAFNETLFRNQLALATWTIQGAANALSGDVWDIDNEF 760


>gi|189458817 transferrin receptor [Homo sapiens]
          Length = 760

 Score = 1531 bits (3964), Expect = 0.0
 Identities = 760/760 (100%), Positives = 760/760 (100%)

Query: 1   MMDQARSAFSNLFGGEPLSYTRFSLARQVDGDNSHVEMKLAVDEEENADNNTKANVTKPK 60
           MMDQARSAFSNLFGGEPLSYTRFSLARQVDGDNSHVEMKLAVDEEENADNNTKANVTKPK
Sbjct: 1   MMDQARSAFSNLFGGEPLSYTRFSLARQVDGDNSHVEMKLAVDEEENADNNTKANVTKPK 60

Query: 61  RCSGSICYGTIAVIVFFLIGFMIGYLGYCKGVEPKTECERLAGTESPVREEPGEDFPAAR 120
           RCSGSICYGTIAVIVFFLIGFMIGYLGYCKGVEPKTECERLAGTESPVREEPGEDFPAAR
Sbjct: 61  RCSGSICYGTIAVIVFFLIGFMIGYLGYCKGVEPKTECERLAGTESPVREEPGEDFPAAR 120

Query: 121 RLYWDDLKRKLSEKLDSTDFTGTIKLLNENSYVPREAGSQKDENLALYVENQFREFKLSK 180
           RLYWDDLKRKLSEKLDSTDFTGTIKLLNENSYVPREAGSQKDENLALYVENQFREFKLSK
Sbjct: 121 RLYWDDLKRKLSEKLDSTDFTGTIKLLNENSYVPREAGSQKDENLALYVENQFREFKLSK 180

Query: 181 VWRDQHFVKIQVKDSAQNSVIIVDKNGRLVYLVENPGGYVAYSKAATVTGKLVHANFGTK 240
           VWRDQHFVKIQVKDSAQNSVIIVDKNGRLVYLVENPGGYVAYSKAATVTGKLVHANFGTK
Sbjct: 181 VWRDQHFVKIQVKDSAQNSVIIVDKNGRLVYLVENPGGYVAYSKAATVTGKLVHANFGTK 240

Query: 241 KDFEDLYTPVNGSIVIVRAGKITFAEKVANAESLNAIGVLIYMDQTKFPIVNAELSFFGH 300
           KDFEDLYTPVNGSIVIVRAGKITFAEKVANAESLNAIGVLIYMDQTKFPIVNAELSFFGH
Sbjct: 241 KDFEDLYTPVNGSIVIVRAGKITFAEKVANAESLNAIGVLIYMDQTKFPIVNAELSFFGH 300

Query: 301 AHLGTGDPYTPGFPSFNHTQFPPSRSSGLPNIPVQTISRAAAEKLFGNMEGDCPSDWKTD 360
           AHLGTGDPYTPGFPSFNHTQFPPSRSSGLPNIPVQTISRAAAEKLFGNMEGDCPSDWKTD
Sbjct: 301 AHLGTGDPYTPGFPSFNHTQFPPSRSSGLPNIPVQTISRAAAEKLFGNMEGDCPSDWKTD 360

Query: 361 STCRMVTSESKNVKLTVSNVLKEIKILNIFGVIKGFVEPDHYVVVGAQRDAWGPGAAKSG 420
           STCRMVTSESKNVKLTVSNVLKEIKILNIFGVIKGFVEPDHYVVVGAQRDAWGPGAAKSG
Sbjct: 361 STCRMVTSESKNVKLTVSNVLKEIKILNIFGVIKGFVEPDHYVVVGAQRDAWGPGAAKSG 420

Query: 421 VGTALLLKLAQMFSDMVLKDGFQPSRSIIFASWSAGDFGSVGATEWLEGYLSSLHLKAFT 480
           VGTALLLKLAQMFSDMVLKDGFQPSRSIIFASWSAGDFGSVGATEWLEGYLSSLHLKAFT
Sbjct: 421 VGTALLLKLAQMFSDMVLKDGFQPSRSIIFASWSAGDFGSVGATEWLEGYLSSLHLKAFT 480

Query: 481 YINLDKAVLGTSNFKVSASPLLYTLIEKTMQNVKHPVTGQFLYQDSNWASKVEKLTLDNA 540
           YINLDKAVLGTSNFKVSASPLLYTLIEKTMQNVKHPVTGQFLYQDSNWASKVEKLTLDNA
Sbjct: 481 YINLDKAVLGTSNFKVSASPLLYTLIEKTMQNVKHPVTGQFLYQDSNWASKVEKLTLDNA 540

Query: 541 AFPFLAYSGIPAVSFCFCEDTDYPYLGTTMDTYKELIERIPELNKVARAAAEVAGQFVIK 600
           AFPFLAYSGIPAVSFCFCEDTDYPYLGTTMDTYKELIERIPELNKVARAAAEVAGQFVIK
Sbjct: 541 AFPFLAYSGIPAVSFCFCEDTDYPYLGTTMDTYKELIERIPELNKVARAAAEVAGQFVIK 600

Query: 601 LTHDVELNLDYERYNSQLLSFVRDLNQYRADIKEMGLSLQWLYSARGDFFRATSRLTTDF 660
           LTHDVELNLDYERYNSQLLSFVRDLNQYRADIKEMGLSLQWLYSARGDFFRATSRLTTDF
Sbjct: 601 LTHDVELNLDYERYNSQLLSFVRDLNQYRADIKEMGLSLQWLYSARGDFFRATSRLTTDF 660

Query: 661 GNAEKTDRFVMKKLNDRVMRVEYHFLSPYVSPKESPFRHVFWGSGSHTLPALLENLKLRK 720
           GNAEKTDRFVMKKLNDRVMRVEYHFLSPYVSPKESPFRHVFWGSGSHTLPALLENLKLRK
Sbjct: 661 GNAEKTDRFVMKKLNDRVMRVEYHFLSPYVSPKESPFRHVFWGSGSHTLPALLENLKLRK 720

Query: 721 QNNGAFNETLFRNQLALATWTIQGAANALSGDVWDIDNEF 760
           QNNGAFNETLFRNQLALATWTIQGAANALSGDVWDIDNEF
Sbjct: 721 QNNGAFNETLFRNQLALATWTIQGAANALSGDVWDIDNEF 760


>gi|33589848 transferrin receptor 2 [Homo sapiens]
          Length = 801

 Score =  563 bits (1450), Expect = e-160
 Identities = 325/730 (44%), Positives = 443/730 (60%), Gaps = 49/730 (6%)

Query: 68  YGTIAVIVFFLIGFMIGYLGYCKGVEPKTECERLAGTESPVRE----EPGEDFPAARRLY 123
           Y  +  ++ F   F++GY+ +      +  C+    +   V E    EP  DF   R LY
Sbjct: 84  YLVLTALLIFTGAFLLGYVAF------RGSCQACGDSVLVVSEDVNYEPDLDFHQGR-LY 136

Query: 124 WDDLKRKLSEKLDSTDFTGTIKLLNENSYVPREAGSQKDENLALYVENQFREFKLSKVWR 183
           W DL+    + L       TI+   + S   R AGS     L   +       KL  VW 
Sbjct: 137 WSDLQAMFLQFLGEGRLEDTIR---QTSLRERVAGSAGMAALTQDIRAALSRQKLDHVWT 193

Query: 184 DQHFVKIQVKDSAQ-NSVIIVDKNGRL--VYLVENPGGYVAYSKAATVTGKLVHANFGTK 240
           D H+V +Q  D A  N++  VD+ G++     +E+P  Y  YS    VTG+LV+A++G  
Sbjct: 194 DTHYVGLQFPDPAHPNTLHWVDEAGKVGEQLPLEDPDVYCPYSAIGNVTGELVYAHYGRP 253

Query: 241 KDFEDLYT----PVNGSIVIVRAGKITFAEKVANAESLNAIGVLIYMDQTKF------PI 290
           +D +DL      PV G +++VR G I+FA+KV NA+   A GVLIY +   F      P 
Sbjct: 254 EDLQDLRARGVDPV-GRLLLVRVGVISFAQKVTNAQDFGAQGVLIYPEPADFSQDPPKPS 312

Query: 291 VNAELSFFGHAHLGTGDPYTPGFPSFNHTQFPPSRSSGLPNIPVQTISRAAAEKLFGNME 350
           ++++ + +GH HLGTGDPYTPGFPSFN TQFPP  SSGLP+IP Q IS   A +L   ++
Sbjct: 313 LSSQQAVYGHVHLGTGDPYTPGFPSFNQTQFPPVASSGLPSIPAQPISADIASRLLRKLK 372

Query: 351 GD-CPSDWKTDSTCRMV-TSESKNVKLTVSNVLKEIKILNIFGVIKGFVEPDHYVVVGAQ 408
           G   P +W+               ++L V+N      I NIFG I+G  EPDHYVV+GAQ
Sbjct: 373 GPVAPQEWQGSLLGSPYHLGPGPRLRLVVNNHRTSTPINNIFGCIEGRSEPDHYVVIGAQ 432

Query: 409 RDAWGPGAAKSGVGTALLLKLAQMFSDMVLKDGFQPSRSIIFASWSAGDFGSVGATEWLE 468
           RDAWGPGAAKS VGTA+LL+L + FS MV  +GF+P RS++F SW  GDFGSVG+TEWLE
Sbjct: 433 RDAWGPGAAKSAVGTAILLELVRTFSSMV-SNGFRPRRSLLFISWDGGDFGSVGSTEWLE 491

Query: 469 GYLSSLHLKAFTYINLDKAVLGTSNFKVSASPLLYTLIEKTMQNVKHPV-TGQFLYQ--- 524
           GYLS LHLKA  Y++LD AVLG   F    SPLL +LIE  ++ V  P  +GQ LY+   
Sbjct: 492 GYLSVLHLKAVVYVSLDNAVLGDDKFHAKTSPLLTSLIESVLKQVDSPNHSGQTLYEQVV 551

Query: 525 --DSNW-ASKVEKLTLDNAAFPFLAYSGIPAVSFCFCEDTD-YPYLGTTMDTYKELIERI 580
             + +W A  +  L +D++A+ F A+ G+PAV F F ED   YP+L T  DTY+ L + +
Sbjct: 552 FTNPSWDAEVIRPLPMDSSAYSFTAFVGVPAVEFSFMEDDQAYPFLHTKEDTYENLHKVL 611

Query: 581 P-ELNKVARAAAEVAGQFVIKLTHDVELNLDYERYNSQLLSFVRDLNQYRADIKEMGLSL 639
              L  VA+A A++AGQ +I+L+HD  L LD+ RY   +L  + +LN++  D+K  GL+L
Sbjct: 612 QGRLPAVAQAVAQLAGQLLIRLSHDRLLPLDFGRYGDVVLRHIGNLNEFSGDLKARGLTL 671

Query: 640 QWLYSARGDFFRATSRLTTDFGNAEKTDRFVMKKLNDRVMRVEYHFLSPYVSPKESPFRH 699
           QW+YSARGD+ RA  +L  +  ++E+ D  + +  N R+MRVE++FLS YVSP +SPFRH
Sbjct: 672 QWVYSARGDYIRAAEKLRQEIYSSEERDERLTRMYNVRIMRVEFYFLSQYVSPADSPFRH 731

Query: 700 VFWGSGSHTLPALLENLKLRKQNNG---------AFNETLFRNQLALATWTIQGAANALS 750
           +F G G HTL ALL++L+L + N+           F E+ FR QLAL TWT+QGAANALS
Sbjct: 732 IFMGRGDHTLGALLDHLRLLRSNSSGTPGATSSTGFQESRFRRQLALLTWTLQGAANALS 791

Query: 751 GDVWDIDNEF 760
           GDVW+IDN F
Sbjct: 792 GDVWNIDNNF 801


>gi|4758398 folate hydrolase 1 isoform 1 [Homo sapiens]
          Length = 750

 Score =  226 bits (576), Expect = 6e-59
 Identities = 182/700 (26%), Positives = 323/700 (46%), Gaps = 84/700 (12%)

Query: 128 KRKLSEKLDSTDFTGTIKLLNENSYVPREAGSQKDENLALYVENQFREFKLSKVWRDQHF 187
           K  +   LD        K L   + +P  AG++++  LA  +++Q++EF L  V    + 
Sbjct: 55  KHNMKAFLDELKAENIKKFLYNFTQIPHLAGTEQNFQLAKQIQSQWKEFGLDSVELAHYD 114

Query: 188 VKIQVKDSAQ-NSVIIVDKNGRLVYLVE----NPGGYV----------AYSKAATVTGKL 232
           V +   +    N + I++++G  ++        P GY           A+S      G L
Sbjct: 115 VLLSYPNKTHPNYISIINEDGNEIFNTSLFEPPPPGYENVSDIVPPFSAFSPQGMPEGDL 174

Query: 233 VHANFGTKKDF----EDLYTPVNGSIVIVRAGKITFAEKVANAESLNAIGVLIYMDQTKF 288
           V+ N+   +DF     D+    +G IVI R GK+    KV NA+   A GV++Y D   +
Sbjct: 175 VYVNYARTEDFFKLERDMKINCSGKIVIARYGKVFRGNKVKNAQLAGAKGVILYSDPADY 234

Query: 289 PIVNAELSFFGHAHL--------------GTGDPYTPGFPSFNHT-QFPPSRSSGLPNIP 333
                + S+    +L              G GDP TPG+P+  +  +   + + GLP+IP
Sbjct: 235 FAPGVK-SYPDGWNLPGGGVQRGNILNLNGAGDPLTPGYPANEYAYRRGIAEAVGLPSIP 293

Query: 334 VQTISRAAAEKLFGNMEGDCPSDWKTDSTCRMVTS---------ESKNVKLTVSNVLKEI 384
           V  I    A+KL   M G  P D     + ++  +          ++ VK+ + +  +  
Sbjct: 294 VHPIGYYDAQKLLEKMGGSAPPDSSWRGSLKVPYNVGPGFTGNFSTQKVKMHIHSTNEVT 353

Query: 385 KILNIFGVIKGFVEPDHYVVVGAQRDAWGPGAAKSGVGTALLLKLAQMFSDMVLKDGFQP 444
           +I N+ G ++G VEPD YV++G  RD+W  G      G A++ ++ + F  +  K+G++P
Sbjct: 354 RIYNVIGTLRGAVEPDRYVILGGHRDSWVFGGIDPQSGAAVVHEIVRSFGTLK-KEGWRP 412

Query: 445 SRSIIFASWSAGDFGSVGATEWLEGYLSSLHLKAFTYINLDKAVLGTSNFKVSASPLLYT 504
            R+I+FASW A +FG +G+TEW E     L  +   YIN D ++ G    +V  +PL+Y+
Sbjct: 413 RRTILFASWDAEEFGLLGSTEWAEENSRLLQERGVAYINADSSIEGNYTLRVDCTPLMYS 472

Query: 505 LIEKTMQNVKHP---VTGQFLYQDSNWASK-----------VEKLTLDNAAFPFLAYSGI 550
           L+    + +K P     G+ LY+  +W  K           + KL   N    F    GI
Sbjct: 473 LVHNLTKELKSPDEGFEGKSLYE--SWTKKSPSPEFSGMPRISKLGSGNDFEVFFQRLGI 530

Query: 551 PAVSFCFCED------TDYPYLGTTMDTYKELIERIPE-LNKVARAAAEVAGQFVIKLTH 603
            +    + ++      + YP   +  +TY EL+E+  + + K     A+V G  V +L +
Sbjct: 531 ASGRARYTKNWETNKFSGYPLYHSVYETY-ELVEKFYDPMFKYHLTVAQVRGGMVFELAN 589

Query: 604 DVELNLDYERYNSQLLSFVRDL----NQYRADIKEMGLSLQWLYSARGDFFRATSRLTTD 659
            + L  D   Y   L  +   +     ++  ++K   +S   L+SA  +F    S+ +  
Sbjct: 590 SIVLPFDCRDYAVVLRKYADKIYSISMKHPQEMKTYSVSFDSLFSAVKNFTEIASKFSER 649

Query: 660 FGNAEKTDRFVMKKLNDRVMRVEYHFLSPYVSPKESPFRHVFWGSGSH------TLPAL- 712
             + +K++  V++ +ND++M +E  F+ P   P    +RHV +   SH      + P + 
Sbjct: 650 LQDFDKSNPIVLRMMNDQLMFLERAFIDPLGLPDRPFYRHVIYAPSSHNKYAGESFPGIY 709

Query: 713 --LENLKLRKQNNGAFNETLFRNQLALATWTIQGAANALS 750
             L +++ +   + A+ E   + Q+ +A +T+Q AA  LS
Sbjct: 710 DALFDIESKVDPSKAWGEV--KRQIYVAAFTVQAAAETLS 747


>gi|4885505 N-acetylated alpha-linked acidic dipeptidase 2 [Homo
           sapiens]
          Length = 740

 Score =  217 bits (552), Expect = 4e-56
 Identities = 195/753 (25%), Positives = 336/753 (44%), Gaps = 107/753 (14%)

Query: 72  AVIVFFLIGFMIGYLGYCKGVEPKTECERLAGTESPVREEPGEDFPAARRLYWDDLKRKL 131
           A +  FL+GFM+G+      ++P  E      T + VR             Y   ++ KL
Sbjct: 16  AALASFLMGFMVGWF-----IKPLKE------TTTSVR-------------YHQSIRWKL 51

Query: 132 SEKLDSTDFTGTIKLLNENSYVPREAGSQKDENLALYVENQFREFKLSKVWRDQHFVKIQ 191
             ++ + +    ++   +   +P  AG++++  LA  ++ Q+++F L       + V + 
Sbjct: 52  VSEMKAENIKSFLRSFTK---LPHLAGTEQNFLLAKKIQTQWKKFGLDSAKLVHYDVLLS 108

Query: 192 VKDSAQ-NSVIIVDKNGRLV----YLVENPGGYV----------AYSKAATVTGKLVHAN 236
             +    N + IVD++   +    YL   P GY           A+S      G LV+ N
Sbjct: 109 YPNETNANYISIVDEHETEIFKTSYLEPPPDGYENVTNIVPPYNAFSAQGMPEGDLVYVN 168

Query: 237 FGTKKDFEDLYTPVN----GSIVIVRAGKITFAEKVANAESLNAIGVLIYMDQTKF---- 288
           +   +DF  L   +     G IVI R GKI    KV NA    AIG+++Y D   +    
Sbjct: 169 YARTEDFFKLEREMGINCTGKIVIARYGKIFRGNKVKNAMLAGAIGIILYSDPADYFAPE 228

Query: 289 ----------PIVNAELSFFGHAHLGTGDPYTPGFPSFNHT-QFPPSRSSGLPNIPVQTI 337
                     P   A+     + + G GDP TPG+P+  +T +       G+P IPV  I
Sbjct: 229 VQPYPKGWNLPGTAAQRGNVLNLN-GAGDPLTPGYPAKEYTFRLDVEEGVGIPRIPVHPI 287

Query: 338 SRAAAEKLFGNMEGDCPSD--WKTDSTCR------MVTSES-KNVKLTVSNVLKEIKILN 388
               AE L   + G  P D  WK               S+S + V++ V N+ K  +I N
Sbjct: 288 GYNDAEILLRYLGGIAPPDKSWKGALNVSYSIGPGFTGSDSFRKVRMHVYNINKITRIYN 347

Query: 389 IFGVIKGFVEPDHYVVVGAQRDAWGPGAAKSGVGTALLLKLAQMFSDMVLKDGFQPSRSI 448
           + G I+G VEPD YV++G  RD+W  GA     G A+L ++A+ F  ++ K G++P R+I
Sbjct: 348 VVGTIRGSVEPDRYVILGGHRDSWVFGAIDPTSGVAVLQEIARSFGKLMSK-GWRPRRTI 406

Query: 449 IFASWSAGDFGSVGATEWLEGYLSSLHLKAFTYINLDKAVLGTSNFKVSASPLLYTLIEK 508
           IFASW A +FG +G+TEW E  +  L  ++  YIN D ++ G    +V  +PLLY L+ K
Sbjct: 407 IFASWDAEEFGLLGSTEWAEENVKILQERSIAYINSDSSIEGNYTLRVDCTPLLYQLVYK 466

Query: 509 TMQNVKHPVTG---QFLYQDSNWASK-----------VEKLTLDNAAFPFLAYSGIPAVS 554
             + +  P  G   + LY+  +W  K           + KL   +    +    GI +  
Sbjct: 467 LTKEIPSPDDGFESKSLYE--SWLEKDPSPENKNLPRINKLGSGSDFEAYFQRLGIASGR 524

Query: 555 FCFCED------TDYPYLGTTMDTYKELIERIPELN-KVARAAAEVAGQFVIKLTHDVEL 607
             + ++      + YP   T  +T+ EL+E+  +   K   + A++ G  V +L     +
Sbjct: 525 ARYTKNKKTDKYSSYPVYHTIYETF-ELVEKFYDPTFKKQLSVAQLRGALVYELVDSKII 583

Query: 608 NLDYERYNSQLLSFVRDL----NQYRADIKEMGLSLQWLYSARGDFFRATSRLTTDFGNA 663
             + + Y   L ++   +     ++   + + G+S   L+SA  +F  A S         
Sbjct: 584 PFNIQDYAEALKNYAASIYNLSKKHDQQLTDHGVSFDSLFSAVKNFSEAASDFHKRLIQV 643

Query: 664 EKTDRFVMKKLNDRVMRVEYHFLSPYVSPKESPFRHVFWGSGSH------TLPALLENL- 716
           +  +   ++ +ND++M +E  F+ P   P +  +RH+ +   SH      + P + + + 
Sbjct: 644 DLNNPIAVRMMNDQLMLLERAFIDPLGLPGKLFYRHIIFAPSSHNKYAGESFPGIYDAIF 703

Query: 717 KLRKQNNGAFNETLFRNQLALATWTIQGAANAL 749
            +  + N        +  +++A +TIQ AA  L
Sbjct: 704 DIENKANSRLAWKEVKKHISIAAFTIQAAAGTL 736


>gi|57232740 N-acetylated alpha-linked acidic dipeptidase-like 1
           [Homo sapiens]
          Length = 740

 Score =  207 bits (527), Expect = 3e-53
 Identities = 181/675 (26%), Positives = 297/675 (44%), Gaps = 73/675 (10%)

Query: 147 LNENSYVPREAGSQKDENLALYVENQFR--EFKLSKVWRDQHFVKIQVKDSAQNSVI-IV 203
           L E S  P  A S +DE+L   +  +++  E  L       + V +      Q +V+ IV
Sbjct: 61  LRELSREPHLASSPRDEDLVQLLLQRWKDPESGLDSAEASTYEVLLSFPSQEQPNVVDIV 120

Query: 204 DKNGRLVYLV----ENPGG----------YVAYSKAATVTGKLVHANFGTKKDFEDLYTP 249
              G +++      EN  G          Y AY+ + T  G LV+AN G ++DF++L T 
Sbjct: 121 GPTGGIIHSCHRTEENVTGEQGGPDVVQPYAAYAPSGTPQGLLVYANRGAEEDFKELQTQ 180

Query: 250 ---VNGSIVIVRAGKITFAEKVANAESLNAIGVLIYMDQTKF------PIVNAELSFF-- 298
              + G+I + R G +    K  NA      GVL+Y D          P      S++  
Sbjct: 181 GIKLEGTIALTRYGGVGRGAKAVNAAKHGVAGVLVYTDPADINDGLSSPDETFPNSWYLP 240

Query: 299 ------GHAHLGTGDPYTPGFPSFNHT-QFPPSRSSGLPNIPVQTISRAAAEKLFGNMEG 351
                 G  +   GDP TP  P+   + +   +  SG P IP Q I    A  L  N+ G
Sbjct: 241 PSGVERGSYYEYFGDPLTPYLPAVPSSFRVDLANVSGFPPIPTQPIGFQDARDLLCNLNG 300

Query: 352 D-CPSDWKTDSTCRMVTSES----------KNVKLTVSNVLKEIKILNIFGVIKGFVEPD 400
              P+ W+    C                   V ++V N L+     N+ G+I+G VEPD
Sbjct: 301 TLAPATWQGALGCHYRLGPGFRPDGDFPADSQVNVSVYNRLELRNSSNVLGIIRGAVEPD 360

Query: 401 HYVVVGAQRDAWGPGAAKSGVGTALLLKLAQMFSDMVLKDGFQPSRSIIFASWSAGDFGS 460
            YV+ G  RD+W  GA     GTA+LL+L+++   ++ K  ++P RSI+FASW A +FG 
Sbjct: 361 RYVLYGNHRDSWVHGAVDPSSGTAVLLELSRVLGTLLKKGTWRPRRSIVFASWGAEEFGL 420

Query: 461 VGATEWLEGYLSSLHLKAFTYINLDKAVLGTSNFKVSASPLLYTLIEKTMQNVKHPVTGQ 520
           +G+TE+ E + + L  +   YIN+D +V   +  +V  +P + +++    + ++ P  G 
Sbjct: 421 IGSTEFTEEFFNKLQERTVAYINVDISVFANATLRVQGTPPVQSVVFSATKEIRSPGPGD 480

Query: 521 FLYQDSNW-------------ASKVEKLTLDNAAFPFLAYSGIPAVSFCFCEDTD----- 562
               D NW                +  L   +   PF+ + GI ++   +  D       
Sbjct: 481 LSIYD-NWIRYFNRSSPVYGLVPSLGSLGAGSDYAPFVHFLGISSMDIAYTYDRSKTSAR 539

Query: 563 -YPYLGTTMDTYKELIERIPELNKVARAAAEVAGQFVIKLTHDVELNLDYERYNSQLLSF 621
            YP   T  DT+  + + +       +A A  AG  +++L+    L L    Y+  L SF
Sbjct: 540 IYPTYHTAFDTFDYVDKFLDPGFSSHQAVARTAGSVILRLSDSFFLPLKVSDYSETLRSF 599

Query: 622 VRDLNQ-YRADIKEMGLSLQWLYSARGDFFRATSRLTTDFGNAEK--TDRFVMKKLNDRV 678
           ++   Q   A +++  +SL  L +A   F    + L       +K   D   ++ LND++
Sbjct: 600 LQAAQQDLGALLEQHSISLGPLVTAVEKFEAEAAALGQRISTLQKGSPDPLQVRMLNDQL 659

Query: 679 MRVEYHFLSPYVSPKESPFRHVFWG--SGSHTLPALLENLKLRKQNNGAFNETL--FRNQ 734
           M +E  FL+P   P+E  + HV W   +GS      L N   R ++  + +E     + Q
Sbjct: 660 MLLERTFLNPRAFPEERYYSHVLWAPRTGSVVTFPGLSNACSRARDTASGSEAWAEVQRQ 719

Query: 735 LALATWTIQGAANAL 749
           L++    ++GAA  L
Sbjct: 720 LSIVVTALEGAAATL 734


>gi|62548858 folate hydrolase 1 isoform 2 [Homo sapiens]
          Length = 719

 Score =  194 bits (492), Expect = 3e-49
 Identities = 173/700 (24%), Positives = 306/700 (43%), Gaps = 115/700 (16%)

Query: 128 KRKLSEKLDSTDFTGTIKLLNENSYVPREAGSQKDENLALYVENQFREFKLSKVWRDQHF 187
           K  +   LD        K L   + +P  AG++++  LA  +++Q++EF L  V    + 
Sbjct: 55  KHNMKAFLDELKAENIKKFLYNFTQIPHLAGTEQNFQLAKQIQSQWKEFGLDSVELAHYD 114

Query: 188 VKIQVKDSAQ-NSVIIVDKNGRLVYLVE----NPGGYV----------AYSKAATVTGKL 232
           V +   +    N + I++++G  ++        P GY           A+S      G L
Sbjct: 115 VLLSYPNKTHPNYISIINEDGNEIFNTSLFEPPPPGYENVSDIVPPFSAFSPQGMPEGDL 174

Query: 233 VHANFGTKKDF----EDLYTPVNGSIVIVRAGKITFAEKVANAESLNAIGVLIYMDQTKF 288
           V+ N+   +DF     D+    +G IVI R GK+    KV NA+   A GV++Y D   +
Sbjct: 175 VYVNYARTEDFFKLERDMKINCSGKIVIARYGKVFRGNKVKNAQLAGAKGVILYSDPADY 234

Query: 289 PIVNAELSFFGHAHL--------------GTGDPYTPGFPSFNHT-QFPPSRSSGLPNIP 333
                + S+    +L              G GDP TPG+P+  +  +   + + GLP+IP
Sbjct: 235 FAPGVK-SYPDGWNLPGGGVQRGNILNLNGAGDPLTPGYPANEYAYRRGIAEAVGLPSIP 293

Query: 334 VQTISRAAAEKLFGNMEGDCPSDWKTDSTCRMVTS---------ESKNVKLTVSNVLKEI 384
           V  I    A+KL   M G  P D     + ++  +          ++ VK+ + +  +  
Sbjct: 294 VHPIGYYDAQKLLEKMGGSAPPDSSWRGSLKVPYNVGPGFTGNFSTQKVKMHIHSTNEVT 353

Query: 385 KILNIFGVIKGFVEPDHYVVVGAQRDAWGPGAAKSGVGTALLLKLAQMFSDMVLKDGFQP 444
           +I N+ G ++G VEPD YV++G  RD+W  G      G A++ ++ + F  +  K+G++P
Sbjct: 354 RIYNVIGTLRGAVEPDRYVILGGHRDSWVFGGIDPQSGAAVVHEIVRSFGTLK-KEGWRP 412

Query: 445 SRSIIFASWSAGDFGSVGATEWLEGYLSSLHLKAFTYINLDKAVLGTSNFKVSASPLLYT 504
            R+I+FASW A +FG +G+TEW E     L  +   YIN D ++ G    +V  +PL+Y+
Sbjct: 413 RRTILFASWDAEEFGLLGSTEWAEENSRLLQERGVAYINADSSIEGNYTLRVDCTPLMYS 472

Query: 505 LIEKTMQNVKHP---VTGQFLYQDSNWASK-----------VEKLTLDNAAFPFLAYSGI 550
           L+    + +K P     G+ LY+  +W  K           + KL   N    F    GI
Sbjct: 473 LVHNLTKELKSPDEGFEGKSLYE--SWTKKSPSPEFSGMPRISKLGSGNDFEVFFQRLGI 530

Query: 551 PAVSFCFCED------TDYPYLGTTMDTYKELIERIPE-LNKVARAAAEVAGQFVIKLTH 603
            +    + ++      + YP   +  +TY EL+E+  + + K     A+V G  V +L +
Sbjct: 531 ASGRARYTKNWETNKFSGYPLYHSVYETY-ELVEKFYDPMFKYHLTVAQVRGGMVFELAN 589

Query: 604 DVELNLDYERYNSQLLSFVRDL----NQYRADIKEMGLSLQWLYSARGDFFRATSRLTTD 659
            + L  D   Y   L  +   +     ++  ++K   +S   L+SA  +F    S+ +  
Sbjct: 590 SIVLPFDCRDYAVVLRKYADKIYSISMKHPQEMKTYSVSFDSLFSAVKNFTEIASKFSER 649

Query: 660 FGNAEKTDRFVMKKLNDRVMRVEYHFLSPYVSPKESPFRHVFWGSGSH------TLPAL- 712
             + +K+                               +HV +   SH      + P + 
Sbjct: 650 LQDFDKS-------------------------------KHVIYAPSSHNKYAGESFPGIY 678

Query: 713 --LENLKLRKQNNGAFNETLFRNQLALATWTIQGAANALS 750
             L +++ +   + A+ E   + Q+ +A +T+Q AA  LS
Sbjct: 679 DALFDIESKVDPSKAWGEV--KRQIYVAAFTVQAAAETLS 716


>gi|24308545 folate hydrolase 1B [Homo sapiens]
          Length = 442

 Score =  156 bits (395), Expect = 6e-38
 Identities = 110/415 (26%), Positives = 204/415 (49%), Gaps = 40/415 (9%)

Query: 370 SKNVKLTVSNVLKEIKILNIFGVIKGFVEPDHYVVVGAQRDAWGPGAAKSGVGTALLLKL 429
           ++ VK+ + +  +  +I N+ G ++G VEPD YV++G  RD+W  G      G A++ + 
Sbjct: 31  TQKVKMHIHSTNEVTRIYNVIGTLRGAVEPDRYVILGGHRDSWVFGGIDPQSGAAVVHET 90

Query: 430 AQMFSDMVLKDGFQPSRSIIFASWSAGDFGSVGATEWLEGYLSSLHLKAFTYINLDKAVL 489
            + F  +  K+G++P R+I+FASW A +FG +G+TEW E     L  +   YIN D ++ 
Sbjct: 91  VRSFGTLK-KEGWRPRRTILFASWDAEEFGLLGSTEWAEDNSRLLQERGVAYINADSSIE 149

Query: 490 GTSNFKVSASPLLYTLIEKTMQNVKHP---VTGQFLYQDSNWASK-----------VEKL 535
           G    +V  +PL+Y+L+    + +K P     G+ LY+  +W  K           + KL
Sbjct: 150 GNYTLRVDCTPLMYSLVYNLTKELKSPDEGFEGKSLYE--SWTKKSPSPEFSGMPRISKL 207

Query: 536 TLDNAAFPFLAYSGIPAVSFCFCED------TDYPYLGTTMDTYKELIERIPE-LNKVAR 588
              N    F    GI +    + ++      + YP   +  +TY EL+E+  + + K   
Sbjct: 208 GSGNDFEVFFQRLGIASGRARYTKNWETNKFSGYPLYHSVYETY-ELVEKFYDPMFKYHL 266

Query: 589 AAAEVAGQFVIKLTHDVELNLDYERYNSQLLSFVRDL----NQYRADIKEMGLSLQWLYS 644
             A+V G  V +L + + L  D   Y   L  +   +     ++  ++K   LS   L+S
Sbjct: 267 TVAQVRGGMVFELANSIVLPFDCRDYAVVLRKYADKIYNISMKHPQEMKTYSLSFDSLFS 326

Query: 645 ARGDFFRATSRLTTDFGNAEKTDRFVMKKLNDRVMRVEYHFLSPYVSPKESPFRHVFWGS 704
           A  +F    S+ +    + +K++  +++ +ND++M +E  F+ P   P    +RHV +  
Sbjct: 327 AVKNFTEIASKFSERLQDFDKSNPILLRMMNDQLMFLERAFIDPLGLPDRPFYRHVIYAP 386

Query: 705 GSH------TLPAL---LENLKLRKQNNGAFNETLFRNQLALATWTIQGAANALS 750
            SH      + P +   L +++ +   + A+ +   + Q+++A +T+Q AA  LS
Sbjct: 387 SSHNKYAGESFPGIYDALFDIESKVDPSKAWGDV--KRQISVAAFTVQAAAETLS 439


>gi|126157508 N-acetylated alpha-linked acidic dipeptidase 2 [Homo
           sapiens]
          Length = 795

 Score =  125 bits (313), Expect = 2e-28
 Identities = 95/344 (27%), Positives = 160/344 (46%), Gaps = 18/344 (5%)

Query: 219 YVAYSKAATVTGKLVHANFGTKKDFEDL--YTPVNGSIVIVRAGKITFAEKVANAESLNA 276
           Y AYS   T+  +++  ++G   D + +     V   I +++ GK+    K+++ E    
Sbjct: 263 YAAYSAKGTLKAEVIDVSYGMADDLKRIRKIKNVTNQIALLKLGKLPLLYKLSSLEKAGF 322

Query: 277 IGVLIYMDQTKFP-IVNAELSFFGHAHLGTGDPYTPGFPSFNHTQFPPSRSSGLPNIPVQ 335
            GVL+Y+D    P  VN     F  +    GDP TPG+PS + + F  SRS+ L ++ VQ
Sbjct: 323 GGVLLYIDPCDLPKTVNPSHDTFMVSLNPGGDPSTPGYPSVDES-FRQSRSN-LTSLLVQ 380

Query: 336 TISRAAAEKLFGNMEGDCPSDWKTDSTCRMVTSESKNVKLTVSNVLKEIKILNIFGVIKG 395
            IS     KL  + +    ++    S+  +  +E + V + V  V K   + N+ G + G
Sbjct: 381 PISAPLVAKLISSPKARTKNE--ACSSLELPNNEIRVVSMQVQTVTKLKTVTNVVGFVMG 438

Query: 396 FVEPDHYVVVGAQRD-AWGPGAAKSGVGTALLLKLAQMFSDMVLKDGFQPSRSIIFASWS 454
              PD Y++VG+    A      +    TA++    +     V K G++P R+I+F SW 
Sbjct: 439 LTSPDRYIIVGSHHHTAHSYNGQEWASSTAIITAFIRALMSKV-KRGWRPDRTIVFCSWG 497

Query: 455 AGDFGSVGATEWLEGYLSSLHLKAFTYINLDKAVLGTSNFKVSASPLLYTL-IEKTMQNV 513
              FG++G+ EW E +   L      YI+L   + G S+    ASP L  L +EK   N 
Sbjct: 498 GTAFGNIGSYEWGEDFKKVLQKNVVAYISLHSPIRGNSSLYPVASPSLQQLVVEKNNFN- 556

Query: 514 KHPVTGQFLYQDSNWASKVEKLTLDNAAFPFLAYSGIPAVSFCF 557
               T +    ++N    +  + +   A  F+ + G+P V F +
Sbjct: 557 ---CTRRAQCPETN----ISSIQIQGDADYFINHLGVPIVQFAY 593


>gi|7706387 plasma glutamate carboxypeptidase [Homo sapiens]
          Length = 472

 Score = 39.3 bits (90), Expect = 0.014
 Identities = 23/83 (27%), Positives = 38/83 (45%), Gaps = 6/83 (7%)

Query: 388 NIFGVIKGFVEPDHYVVVGAQRDAW--GPGAAKSGVGTALLLKLAQMFSDMVLKDGFQPS 445
           N    I G   P+  V+V    D+W  G GA   G G  +  +   +  D+    G +P 
Sbjct: 270 NTVAEITGSKYPEQVVLVSGHLDSWDVGQGAMDDGGGAFISWEALSLIKDL----GLRPK 325

Query: 446 RSIIFASWSAGDFGSVGATEWLE 468
           R++    W+A + G VGA ++ +
Sbjct: 326 RTLRLVLWTAEEQGGVGAFQYYQ 348


>gi|51873031 nicalin [Homo sapiens]
          Length = 563

 Score = 38.9 bits (89), Expect = 0.018
 Identities = 52/214 (24%), Positives = 84/214 (39%), Gaps = 16/214 (7%)

Query: 403 VVVGAQRDAWGP------GAAKSGVGTALLLKLAQMFSDMVLKDGFQPSRSIIFASWSAG 456
           +V+ A  DA+G       GA  +G G ++LL+LA++FS +        + +++F +   G
Sbjct: 219 IVIVAHYDAFGVAPWLSLGADSNGSGVSVLLELARLFSRLYTYKRTHAAYNLLFFASGGG 278

Query: 457 DFGSVGATEWLEGYL-----SSLHLKAFTYINLDKAVLGTS-NFKVSASPLLYTLIEKTM 510
            F   G   WLE  L     S L       + LD    G+S +  VS  P   TL    +
Sbjct: 279 KFNYQGTKRWLEDNLDHTDSSLLQDNVAFVLCLDTVGRGSSLHLHVSKPPREGTLQHAFL 338

Query: 511 QNVKHPVTGQFLYQDSNWASKVEKLTLDNAAFPF--LAYSGIPAVSFCFCEDTDYPYLGT 568
           + ++     QF     +   K   L  D  A+     A   +PA +    E        +
Sbjct: 339 RELETVAAHQFPEVRFSMVHKRINLAEDVLAWEHERFAIRRLPAFTLSHLESHRDGQRSS 398

Query: 569 TMDTYKELIERIPELNKVARAAAEVAGQFVIKLT 602
            MD    +  +   L +  R  AE   + +  LT
Sbjct: 399 IMDVRSRVDSK--TLTRNTRIIAEALTRVIYNLT 430


>gi|29788758 ring finger protein 130 [Homo sapiens]
          Length = 419

 Score = 33.5 bits (75), Expect = 0.75
 Identities = 19/54 (35%), Positives = 29/54 (53%), Gaps = 7/54 (12%)

Query: 254 IVIVRAGKITFAEKVANAESLNAIGVLIYMDQTKFPIVNAELSFFGHAHLGTGD 307
           I +++ G  TF EK++ A   NA+ V+IY +++K   V          H GTGD
Sbjct: 105 IALLQRGNCTFKEKISRAAFHNAVAVVIYNNKSKEEPVTM-------THPGTGD 151


>gi|122937402 transmembrane protein 8C [Homo sapiens]
          Length = 221

 Score = 33.1 bits (74), Expect = 0.99
 Identities = 15/46 (32%), Positives = 22/46 (47%)

Query: 403 VVVGAQRDAWGPGAAKSGVGTALLLKLAQMFSDMVLKDGFQPSRSI 448
           + V    D WG G     +GTA+L+  A+    M  K G  P +S+
Sbjct: 104 IAVRIYHDRWGYGVYSGPIGTAILIIAAKWLQKMKEKKGLYPDKSV 149


>gi|66912176 leucine rich repeat containing 66 [Homo sapiens]
          Length = 880

 Score = 31.2 bits (69), Expect = 3.7
 Identities = 28/98 (28%), Positives = 42/98 (42%), Gaps = 8/98 (8%)

Query: 280 LIYMDQTKFPIVNAELSFFGH-AHLGTGDPYTPGFPSFNHTQFPPSRSSGLPNIPV--QT 336
           L+ + Q +     AE +   H + +  GDP   G PS     FPP   SGL   P   + 
Sbjct: 632 LLSIQQPRLSGARAEEALSAHYSEVPYGDPRDTG-PSV----FPPRWDSGLDVTPANKEP 686

Query: 337 ISRAAAEKLFGNMEGDCPSDWKTDSTCRMVTSESKNVK 374
           + ++        +E DC SD  +  T   ++SES   K
Sbjct: 687 VQKSTPSDTCCELESDCDSDEGSLFTLSSISSESARSK 724


>gi|33286418 pyruvate kinase, muscle isoform M2 [Homo sapiens]
          Length = 531

 Score = 30.8 bits (68), Expect = 4.9
 Identities = 35/128 (27%), Positives = 58/128 (45%), Gaps = 17/128 (13%)

Query: 143 TIKLLNENSYVPREAGSQKDENLA-LYVENQFREFKL-SKVWRDQHFVKIQVKDSAQNSV 200
           T+K+  +N+Y+ +      DEN+  L  +N  +  ++ SK++ D   + +QVK    +  
Sbjct: 139 TLKITLDNAYMEK-----CDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADF- 192

Query: 201 IIVDKNGRLVYLVENPGGYVAYSKAATVTGKLVHANFGTKKDFEDLYTPVNGSIVIVRAG 260
                   LV  VEN GG +   K   + G  V     ++KD +DL   V   + +V A 
Sbjct: 193 --------LVTEVEN-GGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFAS 243

Query: 261 KITFAEKV 268
            I  A  V
Sbjct: 244 FIRKASDV 251


>gi|33286422 pyruvate kinase, muscle isoform M1 [Homo sapiens]
          Length = 531

 Score = 30.8 bits (68), Expect = 4.9
 Identities = 35/128 (27%), Positives = 58/128 (45%), Gaps = 17/128 (13%)

Query: 143 TIKLLNENSYVPREAGSQKDENLA-LYVENQFREFKL-SKVWRDQHFVKIQVKDSAQNSV 200
           T+K+  +N+Y+ +      DEN+  L  +N  +  ++ SK++ D   + +QVK    +  
Sbjct: 139 TLKITLDNAYMEK-----CDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADF- 192

Query: 201 IIVDKNGRLVYLVENPGGYVAYSKAATVTGKLVHANFGTKKDFEDLYTPVNGSIVIVRAG 260
                   LV  VEN GG +   K   + G  V     ++KD +DL   V   + +V A 
Sbjct: 193 --------LVTEVEN-GGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFAS 243

Query: 261 KITFAEKV 268
            I  A  V
Sbjct: 244 FIRKASDV 251


>gi|33286420 pyruvate kinase, muscle isoform M1 [Homo sapiens]
          Length = 531

 Score = 30.8 bits (68), Expect = 4.9
 Identities = 35/128 (27%), Positives = 58/128 (45%), Gaps = 17/128 (13%)

Query: 143 TIKLLNENSYVPREAGSQKDENLA-LYVENQFREFKL-SKVWRDQHFVKIQVKDSAQNSV 200
           T+K+  +N+Y+ +      DEN+  L  +N  +  ++ SK++ D   + +QVK    +  
Sbjct: 139 TLKITLDNAYMEK-----CDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADF- 192

Query: 201 IIVDKNGRLVYLVENPGGYVAYSKAATVTGKLVHANFGTKKDFEDLYTPVNGSIVIVRAG 260
                   LV  VEN GG +   K   + G  V     ++KD +DL   V   + +V A 
Sbjct: 193 --------LVTEVEN-GGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFAS 243

Query: 261 KITFAEKV 268
            I  A  V
Sbjct: 244 FIRKASDV 251


>gi|169218111 PREDICTED: similar to pyruvate kinase, muscle [Homo
           sapiens]
          Length = 364

 Score = 30.8 bits (68), Expect = 4.9
 Identities = 35/128 (27%), Positives = 58/128 (45%), Gaps = 17/128 (13%)

Query: 143 TIKLLNENSYVPREAGSQKDENLA-LYVENQFREFKL-SKVWRDQHFVKIQVKDSAQNSV 200
           T+K+  +N+Y+ +      DEN+  L  +N  +  ++ SK++ D   + +QVK    +  
Sbjct: 139 TLKITLDNAYMEK-----CDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADF- 192

Query: 201 IIVDKNGRLVYLVENPGGYVAYSKAATVTGKLVHANFGTKKDFEDLYTPVNGSIVIVRAG 260
                   LV  VEN GG +   K   + G  V     ++KD +DL   V   + +V A 
Sbjct: 193 --------LVTEVEN-GGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFAS 243

Query: 261 KITFAEKV 268
            I  A  V
Sbjct: 244 FIRKASDV 251


>gi|119120884 fer-1-like 6 [Homo sapiens]
          Length = 1857

 Score = 30.8 bits (68), Expect = 4.9
 Identities = 22/47 (46%), Positives = 30/47 (63%), Gaps = 3/47 (6%)

Query: 133  EKLDSTDFTGTIKLLNENSYVPREAGSQKDENLALYVENQFREFKLS 179
            E+L S DF GT++ +N NS+ PR A S K  +LA + EN   E K+S
Sbjct: 1700 ERLSSDDFLGTLE-MNLNSF-PRAAKSAKACDLAKF-ENASEETKIS 1743


>gi|163310725 ER degradation enhancer, mannosidase alpha-like 3
           [Homo sapiens]
          Length = 932

 Score = 30.4 bits (67), Expect = 6.4
 Identities = 19/67 (28%), Positives = 31/67 (46%), Gaps = 12/67 (17%)

Query: 218 GYVAYSKAATVTGKLVHANFGTKKDFEDLYTPVNGSIVIVRAGKITFAEKVANAESLNAI 277
           G+VA SK +    +L +               V G I +++ G+  FAEK  N ++  AI
Sbjct: 682 GFVASSKPSNGCSELTNPE------------AVMGKIALIQRGQCMFAEKARNIQNAGAI 729

Query: 278 GVLIYMD 284
           G ++  D
Sbjct: 730 GGIVIDD 736


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.135    0.399 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,417,776
Number of Sequences: 37866
Number of extensions: 1195272
Number of successful extensions: 2863
Number of sequences better than 10.0: 20
Number of HSP's better than 10.0 without gapping: 13
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 2804
Number of HSP's gapped (non-prelim): 21
length of query: 760
length of database: 18,247,518
effective HSP length: 110
effective length of query: 650
effective length of database: 14,082,258
effective search space: 9153467700
effective search space used: 9153467700
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.