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Search of human proteins with 189083762
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|189083762 gamma-aminobutyric acid A receptor, gamma 2
isoform 3 precursor [Homo sapiens]
(515 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|189083762 gamma-aminobutyric acid A receptor, gamma 2 isoform... 1064 0.0
gi|38788155 gamma-aminobutyric acid A receptor, gamma 2 isoform ... 962 0.0
gi|38788135 gamma-aminobutyric acid A receptor, gamma 2 isoform ... 939 0.0
gi|31742490 gamma-aminobutyric acid A receptor, gamma 1 precurso... 691 0.0
gi|110347416 gamma-aminobutyric acid (GABA) A receptor, gamma 3 ... 637 0.0
gi|52426761 gamma-aminobutyric acid (GABA) A receptor, epsilon p... 388 e-108
gi|157389018 gamma-aminobutyric acid A receptor, alpha 6 precurs... 367 e-101
gi|4557603 gamma-aminobutyric acid A receptor, alpha 3 precursor... 362 e-100
gi|189083734 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ... 357 2e-98
gi|189083732 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ... 357 2e-98
gi|189083730 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ... 357 2e-98
gi|189083728 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ... 357 2e-98
gi|189083726 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ... 357 2e-98
gi|189083724 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ... 357 2e-98
gi|38327554 gamma-aminobutyric acid (GABA) A receptor, alpha 1 p... 357 2e-98
gi|34452723 gamma-aminobutyric acid A receptor, alpha 4 precurso... 346 3e-95
gi|4503861 gamma-aminobutyric acid (GABA) A receptor, alpha 5 pr... 344 1e-94
gi|167000817 gamma-aminobutyric acid A receptor, alpha 2 [Homo s... 341 8e-94
gi|167000751 gamma-aminobutyric acid A receptor, alpha 2 precurs... 341 8e-94
gi|194097327 gamma-aminobutyric acid (GABA) A receptor, beta 1 p... 275 9e-74
gi|4503865 gamma-aminobutyric acid (GABA) A receptor, beta 2 iso... 271 1e-72
gi|12548788 gamma-aminobutyric acid (GABA) A receptor, beta 3 is... 265 7e-71
gi|4503867 gamma-aminobutyric acid (GABA) A receptor, beta 3 iso... 265 7e-71
gi|34734071 gamma-aminobutyric acid (GABA) A receptor, delta pre... 264 2e-70
gi|12548785 gamma-aminobutyric acid (GABA) A receptor, beta 2 is... 260 2e-69
gi|225903367 glycine receptor, alpha 1 isoform 1 precursor [Homo... 246 5e-65
gi|110347441 glycine receptor, alpha 3 isoform a [Homo sapiens] 242 7e-64
gi|110347433 glycine receptor, alpha 3 isoform b [Homo sapiens] 241 9e-64
gi|169646723 glycine receptor, alpha 2 isoform A [Homo sapiens] 238 1e-62
gi|4504021 glycine receptor, alpha 2 isoform A [Homo sapiens] 238 1e-62
>gi|189083762 gamma-aminobutyric acid A receptor, gamma 2 isoform 3
precursor [Homo sapiens]
Length = 515
Score = 1064 bits (2752), Expect = 0.0
Identities = 515/515 (100%), Positives = 515/515 (100%)
Query: 1 MSSPNIWSTGSSVYSTPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPK 60
MSSPNIWSTGSSVYSTPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPK
Sbjct: 1 MSSPNIWSTGSSVYSTPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPK 60
Query: 61 VPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQT 120
VPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQT
Sbjct: 61 VPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQT 120
Query: 121 WYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLY 180
WYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLY
Sbjct: 121 WYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLY 180
Query: 181 TLRLTIDAECQLQLHNFPMDEHSCPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPP 240
TLRLTIDAECQLQLHNFPMDEHSCPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPP
Sbjct: 181 TLRLTIDAECQLQLHNFPMDEHSCPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPP 240
Query: 241 TLASRVAGISDGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYV 300
TLASRVAGISDGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYV
Sbjct: 241 TLASRVAGISDGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYV 300
Query: 301 VMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLST 360
VMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLST
Sbjct: 301 VMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLST 360
Query: 361 IARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKKNPLLRM 420
IARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKKNPLLRM
Sbjct: 361 IARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKKNPLLRM 420
Query: 421 FSFKAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDCRTGAWRHG 480
FSFKAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDCRTGAWRHG
Sbjct: 421 FSFKAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDCRTGAWRHG 480
Query: 481 RIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL 515
RIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL
Sbjct: 481 RIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL 515
>gi|38788155 gamma-aminobutyric acid A receptor, gamma 2 isoform 1
precursor [Homo sapiens]
Length = 475
Score = 962 bits (2486), Expect = 0.0
Identities = 474/515 (92%), Positives = 475/515 (92%), Gaps = 40/515 (7%)
Query: 1 MSSPNIWSTGSSVYSTPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPK 60
MSSPNIWSTGSSVYSTPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPK
Sbjct: 1 MSSPNIWSTGSSVYSTPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPK 60
Query: 61 VPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQT 120
VPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQT
Sbjct: 61 VPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQT 120
Query: 121 WYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLY 180
WYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLY
Sbjct: 121 WYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLY 180
Query: 181 TLRLTIDAECQLQLHNFPMDEHSCPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPP 240
TLRLTIDAECQLQLHNFPMDEHSCPLEFSS+
Sbjct: 181 TLRLTIDAECQLQLHNFPMDEHSCPLEFSSY----------------------------- 211
Query: 241 TLASRVAGISDGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYV 300
GYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYV
Sbjct: 212 -----------GYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYV 260
Query: 301 VMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLST 360
VMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLST
Sbjct: 261 VMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLST 320
Query: 361 IARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKKNPLLRM 420
IARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKKNPLLRM
Sbjct: 321 IARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKKNPLLRM 380
Query: 421 FSFKAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDCRTGAWRHG 480
FSFKAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDCRTGAWRHG
Sbjct: 381 FSFKAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDCRTGAWRHG 440
Query: 481 RIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL 515
RIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL
Sbjct: 441 RIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL 475
>gi|38788135 gamma-aminobutyric acid A receptor, gamma 2 isoform 2
precursor [Homo sapiens]
Length = 467
Score = 939 bits (2428), Expect = 0.0
Identities = 466/515 (90%), Positives = 467/515 (90%), Gaps = 48/515 (9%)
Query: 1 MSSPNIWSTGSSVYSTPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPK 60
MSSPNIWSTGSSVYSTPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPK
Sbjct: 1 MSSPNIWSTGSSVYSTPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPK 60
Query: 61 VPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQT 120
VPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQT
Sbjct: 61 VPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQT 120
Query: 121 WYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLY 180
WYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLY
Sbjct: 121 WYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLY 180
Query: 181 TLRLTIDAECQLQLHNFPMDEHSCPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPP 240
TLRLTIDAECQLQLHNFPMDEHSCPLEFSS+
Sbjct: 181 TLRLTIDAECQLQLHNFPMDEHSCPLEFSSY----------------------------- 211
Query: 241 TLASRVAGISDGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYV 300
GYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYV
Sbjct: 212 -----------GYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYV 260
Query: 301 VMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLST 360
VMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLST
Sbjct: 261 VMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLST 320
Query: 361 IARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKKNPLLRM 420
IARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKKNP
Sbjct: 321 IARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKKNP---- 376
Query: 421 FSFKAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDCRTGAWRHG 480
APTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDCRTGAWRHG
Sbjct: 377 ----APTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDCRTGAWRHG 432
Query: 481 RIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL 515
RIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL
Sbjct: 433 RIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL 467
>gi|31742490 gamma-aminobutyric acid A receptor, gamma 1 precursor
[Homo sapiens]
Length = 465
Score = 691 bits (1783), Expect = 0.0
Identities = 344/491 (70%), Positives = 389/491 (79%), Gaps = 51/491 (10%)
Query: 27 ILLLLSLYPGFTSQKSDD-DYEDYASNKTWVLTPKVPEGDVTVILNNLLEGYDNKLRPDI 85
+ LLL+L+ G K+DD D ED NKTWVL PK+ EGD+T ILN+LL+GYDNKLRPDI
Sbjct: 24 VFLLLTLHLGNCVDKADDEDDEDLTVNKTWVLAPKIHEGDITQILNSLLQGYDNKLRPDI 83
Query: 86 GVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIKVLRLNSNMVGKI 145
GV+PT+I TD+YVNSIGPV+ INMEYTIDI FAQTW+D RLKFNST+KVL LNSNMVGKI
Sbjct: 84 GVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWFDSRLKFNSTMKVLMLNSNMVGKI 143
Query: 146 WIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLHNFPMDEHSCP 205
WIPDTFFRNS+K+DAHWITTPNR+LRIWNDGRVLYTLRLTI+AEC LQLHNFPMDEHSCP
Sbjct: 144 WIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVLYTLRLTINAECYLQLHNFPMDEHSCP 203
Query: 206 LEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPPTLASRVAGISDGYPREEIVYQWKRS 265
LEFSS+ GYP+ EI Y+WK+
Sbjct: 204 LEFSSY----------------------------------------GYPKNEIEYKWKKP 223
Query: 266 SVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTL 325
SVEV D + WRLYQF+FVGLRN+TE+ T SGDYV+M+++FDLSRRMGYFTIQTYIPC L
Sbjct: 224 SVEVADPKYWRLYQFAFVGLRNSTEITHTISGDYVIMTIFFDLSRRMGYFTIQTYIPCIL 283
Query: 326 IVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIF 385
VVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIF
Sbjct: 284 TVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIF 343
Query: 386 VFSALVEYGTLHYFVSNRK-PSKDKDKKKKNPLLRMFSFKAPTIDIRPRSATIQMNNATH 444
VF+AL+EYGTLHYF SN+K + KD+K KN + T + P S I MNN +
Sbjct: 344 VFAALMEYGTLHYFTSNQKGKTATKDRKLKNK-------ASMTPGLHPGSTLIPMNNISV 396
Query: 445 LQERDEEYGYECLDGKDCASFFCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLF 504
QE ++YGY+CL+GKDCASFFCCFEDCRTG+WR GRIHIRIAK+DSY+RIFFPTAF LF
Sbjct: 397 PQE--DDYGYQCLEGKDCASFFCCFEDCRTGSWREGRIHIRIAKIDSYSRIFFPTAFALF 454
Query: 505 NLVYWVSYLYL 515
NLVYWV YLYL
Sbjct: 455 NLVYWVGYLYL 465
>gi|110347416 gamma-aminobutyric acid (GABA) A receptor, gamma 3
[Homo sapiens]
Length = 467
Score = 637 bits (1644), Expect = 0.0
Identities = 314/505 (62%), Positives = 384/505 (76%), Gaps = 58/505 (11%)
Query: 27 ILLLLSLYPGFTSQK---SDDDYEDYASNKTWVLTPKVPEGDVTVILNNLLEGYDNKLRP 83
+LLLL L+ G ++ +D+YED +SN+ WVL PK + DVT+ILN LL YD KLRP
Sbjct: 5 LLLLLCLFSGLHARSRKVEEDEYEDSSSNQKWVLAPKSQDTDVTLILNKLLREYDKKLRP 64
Query: 84 DIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIKVLRLNSNMVG 143
DIG+KPT+I D+YVNSIGPV++INMEY IDIFFAQTW D RL+FNST+K+L LNSNMVG
Sbjct: 65 DIGIKPTVIDVDIYVNSIGPVSSINMEYQIDIFFAQTWTDSRLRFNSTMKILTLNSNMVG 124
Query: 144 KIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLHNFPMDEHS 203
IWIPDT FRNSK A+AHWITTPN++LRIWNDG++LYTLRLTI+AECQLQLHNFPMDEHS
Sbjct: 125 LIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKILYTLRLTINAECQLQLHNFPMDEHS 184
Query: 204 CPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPPTLASRVAGISDGYPREEIVYQWK 263
CPL FSS+ GYP+EE++Y+W+
Sbjct: 185 CPLIFSSY----------------------------------------GYPKEEMIYRWR 204
Query: 264 RSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPC 323
++SVE D +SWRLYQF F+GLRNTTE+V T++GDYVVM++YF+LSRRMGYFTIQTYIPC
Sbjct: 205 KNSVEAADQKSWRLYQFDFMGLRNTTEIVTTSAGDYVVMTIYFELSRRMGYFTIQTYIPC 264
Query: 324 TLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCF 383
L VVLSWVSFWI KDA PART+LGITTVLTMTTLSTIARKSLP+VSYVTAMDLFV+VCF
Sbjct: 265 ILTVVLSWVSFWIKKDATPARTALGITTVLTMTTLSTIARKSLPRVSYVTAMDLFVTVCF 324
Query: 384 IFVFSALVEYGTLHYFVSNRKPSKDK--------DKKKKNPLLRMFSFKAPT----IDIR 431
+FVF+AL+EY TL+Y+ S RKP+ K D + P S +AP+ +D+R
Sbjct: 325 LFVFAALMEYATLNYYSSCRKPTTTKKTTSLLHPDSSRWIP--ERISLQAPSNYSLLDMR 382
Query: 432 -PRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDCRTGAWRHGRIHIRIAKMD 490
P +A I +NN+ + QE ++ YECLDGKDC SFFCC+E+C++G+WR GRIHI I ++D
Sbjct: 383 PPPTAMITLNNSVYWQEFEDTCVYECLDGKDCQSFFCCYEECKSGSWRKGRIHIDILELD 442
Query: 491 SYARIFFPTAFCLFNLVYWVSYLYL 515
SY+R+FFPT+F LFNLVYWV YLYL
Sbjct: 443 SYSRVFFPTSFLLFNLVYWVGYLYL 467
>gi|52426761 gamma-aminobutyric acid (GABA) A receptor, epsilon
precursor [Homo sapiens]
Length = 506
Score = 388 bits (997), Expect = e-108
Identities = 197/493 (39%), Positives = 288/493 (58%), Gaps = 90/493 (18%)
Query: 60 KVPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQ 119
K+PE + ILN +L YD+KLRP IG KPT++ ++ VNS+GP++ ++MEYTIDI F+Q
Sbjct: 67 KLPEA--SRILNTILSNYDHKLRPGIGEKPTVVTVEISVNSLGPLSILDMEYTIDIIFSQ 124
Query: 120 TWYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVL 179
TWYD RL +N T + L LN N+V ++WIPDTFFRNSK+ H IT PN+M+RI+ DG+VL
Sbjct: 125 TWYDERLCYNDTFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITMPNQMVRIYKDGKVL 184
Query: 180 YTLRLTIDAECQLQLHNFPMDEHSCPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDP 239
YT+R+TIDA C L + FPMD HSCPL FSS+S
Sbjct: 185 YTIRMTIDAGCSLHMLRFPMDSHSCPLSFSSFS--------------------------- 217
Query: 240 PTLASRVAGISDGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDY 299
YP E++Y+W+ +E+ + SW+L+QF F G+ N TE++ T GD+
Sbjct: 218 -------------YPENEMIYKWENFKLEINEKNSWKLFQFDFTGVSNKTEIITTPVGDF 264
Query: 300 VVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLS 359
+VM+++F++SRR GY Q Y+P ++ +LSWVSFWI ++ PARTSLGIT+VLTMTTL
Sbjct: 265 MVMTIFFNVSRRFGYVAFQNYVPSSVTTMLSWVSFWIKTESAPARTSLGITSVLTMTTLG 324
Query: 360 TIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKKNPLLR 419
T +RK+ P+VSY+TA+D ++++CF+F F AL+E+ L++ + N + K +P LR
Sbjct: 325 TFSRKNFPRVSYITALDFYIAICFVFCFCALLEFAVLNFLIYN------QTKAHASPKLR 378
Query: 420 MFSFKAPTIDIRPRSATIQMNNATHLQERD----EEYGYECLDGKDCAS----------- 464
P I+ R + T + A Q ++ + E DG++ S
Sbjct: 379 -----HPRINSRAHARTRARSRACARQHQEAFVCQIVTTEGSDGEERPSCSAQQPPSPGS 433
Query: 465 ----------------------FFCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFC 502
+FC DC W+ GR+ I + ++D+Y+R+ FP F
Sbjct: 434 PEGPRSLCSKLACCEWCKRFKKYFCMVPDCEGSTWQQGRLCIHVYRLDNYSRVVFPVTFF 493
Query: 503 LFNLVYWVSYLYL 515
FN++YW+ L L
Sbjct: 494 FFNVLYWLVCLNL 506
>gi|157389018 gamma-aminobutyric acid A receptor, alpha 6 precursor
[Homo sapiens]
Length = 453
Score = 367 bits (941), Expect = e-101
Identities = 207/462 (44%), Positives = 277/462 (59%), Gaps = 64/462 (13%)
Query: 65 DVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDR 124
+V+ IL+NLLEGYDN+LRP G T + TD+YV S GPV+ + MEYT+D+FF QTW D
Sbjct: 31 NVSRILDNLLEGYDNRLRPGFGGAVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWTDE 90
Query: 125 RLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRL 184
RLKF ++L LN+ MV KIW PDTFFRN KK+ AH +TTPN++ RI +G +LYT+RL
Sbjct: 91 RLKFGGPTEILSLNNLMVSKIWTPDTFFRNGKKSIAHNMTTPNKLFRIMQNGTILYTMRL 150
Query: 185 TIDAECQLQLHNFPMDEHSCPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPPTLAS 244
TI+A+C ++L NFPMD H+CPL+F S++
Sbjct: 151 TINADCPMRLVNFPMDGHACPLKFGSYA-------------------------------- 178
Query: 245 RVAGISDGYPREEIVYQWKRS---SVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVV 301
YP+ EI+Y WK+ SVEV + S L Q+ +G ++E +K+ +G+YV+
Sbjct: 179 --------YPKSEIIYTWKKGPLYSVEVPEESS-SLLQYDLIGQTVSSETIKSNTGEYVI 229
Query: 302 MSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTI 361
M+VYF L R+MGYF IQ Y PC + V+LS VSFWINK++VPART GITTVLTMTTLS
Sbjct: 230 MTVYFHLQRKMGYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSIS 289
Query: 362 ARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKKNPLLRMF 421
AR SLPKVSY TAMD F++VCF FVFSAL+E+ ++YF +N + K K K +
Sbjct: 290 ARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYF-TNLQTQKAKRKAQ-------- 340
Query: 422 SFKA-PTIDI----RPRSATIQM--NNATHLQERDEEYGYECLDGKDCASFFCCFEDCRT 474
F A PT+ I P A I + ++ HL++R + + ++
Sbjct: 341 -FAAPPTVTISKATEPLEAEIVLHPDSKYHLKKRITSLSLPIVSSSEANKVLTRAPILQS 399
Query: 475 GAWRHGRIHIRI---AKMDSYARIFFPTAFCLFNLVYWVSYL 513
+ +K+D Y+RI FP AF FNLVYWV YL
Sbjct: 400 TPVTPPPLSPAFGGTSKIDQYSRILFPVAFAGFNLVYWVVYL 441
>gi|4557603 gamma-aminobutyric acid A receptor, alpha 3 precursor
[Homo sapiens]
Length = 492
Score = 362 bits (929), Expect = e-100
Identities = 208/509 (40%), Positives = 291/509 (57%), Gaps = 67/509 (13%)
Query: 27 ILLLLSLYPGFTSQKSDDDYE--DYASNKTWVLTPK----VPEGDV------TVILNNLL 74
IL L+++ PG T Q E D+ L+PK +P+ T IL+ LL
Sbjct: 16 ILFLINILPGTTGQGESRRQEPGDFVKQDIGGLSPKHAPDIPDDSTDNITIFTRILDRLL 75
Query: 75 EGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIKV 134
+GYDN+LRP +G T + TD+YV S GPV+ +MEYTID+FF QTW+D RLKF+ +K+
Sbjct: 76 DGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQTWHDERLKFDGPMKI 135
Query: 135 LRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQL 194
L LN+ + KIW PDTFF N KK+ AH +TTPN++LR+ ++G +LYT+RLTI AEC + L
Sbjct: 136 LPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYTMRLTIHAECPMHL 195
Query: 195 HNFPMDEHSCPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPPTLASRVAGISDGYP 254
+FPMD H+CPL+F S++ Y
Sbjct: 196 EDFPMDVHACPLKFGSYA----------------------------------------YT 215
Query: 255 REEIVYQW---KRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRR 311
E+VY W K SVEV S RL Q+ +G TE++++++G+YVVM+ +F L R+
Sbjct: 216 TAEVVYSWTLGKNKSVEVAQDGS-RLNQYDLLGHVVGTEIIRSSTGEYVVMTTHFHLKRK 274
Query: 312 MGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSY 371
+GYF IQTY+PC + V+LS VSFW+N+++VPART G+TTVLTMTTLS AR SLPKV+Y
Sbjct: 275 IGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAY 334
Query: 372 VTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKKNPLLRMFSFKAPTIDIR 431
TAMD F++VC+ FVFSAL+E+ T++YF K S + KK L M K P +
Sbjct: 335 ATAMDWFIAVCYAFVFSALIEFATVNYFT---KRSWAWEGKKVPEALEM-KKKTPAAPAK 390
Query: 432 PRSATIQMNNATH--LQERDEEYGYECLDGKDCASFFCCFEDCRTGAW-----RHGRIHI 484
S T + T+ +D E+ AS + + +
Sbjct: 391 KTSTTFNIVGTTYPINLAKDTEFSTISKGAAPSASSTPTIIASPKATYVQDSPTETKTYN 450
Query: 485 RIAKMDSYARIFFPTAFCLFNLVYWVSYL 513
++K+D +RI FP F +FNLVYW +Y+
Sbjct: 451 SVSKVDKISRIIFPVLFAIFNLVYWATYV 479
>gi|189083734 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 357 bits (915), Expect = 2e-98
Identities = 208/508 (40%), Positives = 289/508 (56%), Gaps = 78/508 (15%)
Query: 16 TPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKVPEGDVTVILNNLLE 75
+P S + WILLL +L Q S +D + T V T IL+ LL+
Sbjct: 4 SPGLSDCLWAWILLLSTLTGRSYGQPS---LQDELKDNTTVFTR---------ILDRLLD 51
Query: 76 GYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIKVL 135
GYDN+LRP +G + T + TD++V S GPV+ +MEYTID+FF Q+W D RLKF + VL
Sbjct: 52 GYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVL 111
Query: 136 RLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLH 195
RLN+ M KIW PDTFF N KK+ AH +T PN++LRI DG +LYT+RLT+ AEC + L
Sbjct: 112 RLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLE 171
Query: 196 NFPMDEHSCPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPPTLASRVAGISDGYPR 255
+FPMD H+CPL+F S++ Y R
Sbjct: 172 DFPMDAHACPLKFGSYA----------------------------------------YTR 191
Query: 256 EEIVYQWKRS---SVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRM 312
E+VY+W R SV V + S RL Q+ +G + +V++++G+YVVM+ +F L R++
Sbjct: 192 AEVVYEWTREPARSVVVAEDGS-RLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKI 250
Query: 313 GYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYV 372
GYF IQTY+PC + V+LS VSFW+N+++VPART G+TTVLTMTTLS AR SLPKV+Y
Sbjct: 251 GYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYA 310
Query: 373 TAMDLFVSVCFIFVFSALVEYGTLHYFV------SNRKPSKDKDKKKKNPLLRMFSFKAP 426
TAMD F++VC+ FVFSAL+E+ T++YF + +K KK K+PL++ + AP
Sbjct: 311 TAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAP 370
Query: 427 T-IDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDCRTGAWRHGRIHIR 485
T P A AT + ++ K+ T +
Sbjct: 371 TATSYTPNLARGDPGLATIAKS-------ATIEPKEVKP--------ETKPPEPKKTFNS 415
Query: 486 IAKMDSYARIFFPTAFCLFNLVYWVSYL 513
++K+D +RI FP F +FNLVYW +YL
Sbjct: 416 VSKIDRLSRIAFPLLFGIFNLVYWATYL 443
>gi|189083732 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 357 bits (915), Expect = 2e-98
Identities = 208/508 (40%), Positives = 289/508 (56%), Gaps = 78/508 (15%)
Query: 16 TPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKVPEGDVTVILNNLLE 75
+P S + WILLL +L Q S +D + T V T IL+ LL+
Sbjct: 4 SPGLSDCLWAWILLLSTLTGRSYGQPS---LQDELKDNTTVFTR---------ILDRLLD 51
Query: 76 GYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIKVL 135
GYDN+LRP +G + T + TD++V S GPV+ +MEYTID+FF Q+W D RLKF + VL
Sbjct: 52 GYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVL 111
Query: 136 RLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLH 195
RLN+ M KIW PDTFF N KK+ AH +T PN++LRI DG +LYT+RLT+ AEC + L
Sbjct: 112 RLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLE 171
Query: 196 NFPMDEHSCPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPPTLASRVAGISDGYPR 255
+FPMD H+CPL+F S++ Y R
Sbjct: 172 DFPMDAHACPLKFGSYA----------------------------------------YTR 191
Query: 256 EEIVYQWKRS---SVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRM 312
E+VY+W R SV V + S RL Q+ +G + +V++++G+YVVM+ +F L R++
Sbjct: 192 AEVVYEWTREPARSVVVAEDGS-RLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKI 250
Query: 313 GYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYV 372
GYF IQTY+PC + V+LS VSFW+N+++VPART G+TTVLTMTTLS AR SLPKV+Y
Sbjct: 251 GYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYA 310
Query: 373 TAMDLFVSVCFIFVFSALVEYGTLHYFV------SNRKPSKDKDKKKKNPLLRMFSFKAP 426
TAMD F++VC+ FVFSAL+E+ T++YF + +K KK K+PL++ + AP
Sbjct: 311 TAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAP 370
Query: 427 T-IDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDCRTGAWRHGRIHIR 485
T P A AT + ++ K+ T +
Sbjct: 371 TATSYTPNLARGDPGLATIAKS-------ATIEPKEVKP--------ETKPPEPKKTFNS 415
Query: 486 IAKMDSYARIFFPTAFCLFNLVYWVSYL 513
++K+D +RI FP F +FNLVYW +YL
Sbjct: 416 VSKIDRLSRIAFPLLFGIFNLVYWATYL 443
>gi|189083730 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 357 bits (915), Expect = 2e-98
Identities = 208/508 (40%), Positives = 289/508 (56%), Gaps = 78/508 (15%)
Query: 16 TPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKVPEGDVTVILNNLLE 75
+P S + WILLL +L Q S +D + T V T IL+ LL+
Sbjct: 4 SPGLSDCLWAWILLLSTLTGRSYGQPS---LQDELKDNTTVFTR---------ILDRLLD 51
Query: 76 GYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIKVL 135
GYDN+LRP +G + T + TD++V S GPV+ +MEYTID+FF Q+W D RLKF + VL
Sbjct: 52 GYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVL 111
Query: 136 RLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLH 195
RLN+ M KIW PDTFF N KK+ AH +T PN++LRI DG +LYT+RLT+ AEC + L
Sbjct: 112 RLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLE 171
Query: 196 NFPMDEHSCPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPPTLASRVAGISDGYPR 255
+FPMD H+CPL+F S++ Y R
Sbjct: 172 DFPMDAHACPLKFGSYA----------------------------------------YTR 191
Query: 256 EEIVYQWKRS---SVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRM 312
E+VY+W R SV V + S RL Q+ +G + +V++++G+YVVM+ +F L R++
Sbjct: 192 AEVVYEWTREPARSVVVAEDGS-RLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKI 250
Query: 313 GYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYV 372
GYF IQTY+PC + V+LS VSFW+N+++VPART G+TTVLTMTTLS AR SLPKV+Y
Sbjct: 251 GYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYA 310
Query: 373 TAMDLFVSVCFIFVFSALVEYGTLHYFV------SNRKPSKDKDKKKKNPLLRMFSFKAP 426
TAMD F++VC+ FVFSAL+E+ T++YF + +K KK K+PL++ + AP
Sbjct: 311 TAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAP 370
Query: 427 T-IDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDCRTGAWRHGRIHIR 485
T P A AT + ++ K+ T +
Sbjct: 371 TATSYTPNLARGDPGLATIAKS-------ATIEPKEVKP--------ETKPPEPKKTFNS 415
Query: 486 IAKMDSYARIFFPTAFCLFNLVYWVSYL 513
++K+D +RI FP F +FNLVYW +YL
Sbjct: 416 VSKIDRLSRIAFPLLFGIFNLVYWATYL 443
>gi|189083728 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 357 bits (915), Expect = 2e-98
Identities = 208/508 (40%), Positives = 289/508 (56%), Gaps = 78/508 (15%)
Query: 16 TPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKVPEGDVTVILNNLLE 75
+P S + WILLL +L Q S +D + T V T IL+ LL+
Sbjct: 4 SPGLSDCLWAWILLLSTLTGRSYGQPS---LQDELKDNTTVFTR---------ILDRLLD 51
Query: 76 GYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIKVL 135
GYDN+LRP +G + T + TD++V S GPV+ +MEYTID+FF Q+W D RLKF + VL
Sbjct: 52 GYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVL 111
Query: 136 RLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLH 195
RLN+ M KIW PDTFF N KK+ AH +T PN++LRI DG +LYT+RLT+ AEC + L
Sbjct: 112 RLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLE 171
Query: 196 NFPMDEHSCPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPPTLASRVAGISDGYPR 255
+FPMD H+CPL+F S++ Y R
Sbjct: 172 DFPMDAHACPLKFGSYA----------------------------------------YTR 191
Query: 256 EEIVYQWKRS---SVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRM 312
E+VY+W R SV V + S RL Q+ +G + +V++++G+YVVM+ +F L R++
Sbjct: 192 AEVVYEWTREPARSVVVAEDGS-RLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKI 250
Query: 313 GYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYV 372
GYF IQTY+PC + V+LS VSFW+N+++VPART G+TTVLTMTTLS AR SLPKV+Y
Sbjct: 251 GYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYA 310
Query: 373 TAMDLFVSVCFIFVFSALVEYGTLHYFV------SNRKPSKDKDKKKKNPLLRMFSFKAP 426
TAMD F++VC+ FVFSAL+E+ T++YF + +K KK K+PL++ + AP
Sbjct: 311 TAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAP 370
Query: 427 T-IDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDCRTGAWRHGRIHIR 485
T P A AT + ++ K+ T +
Sbjct: 371 TATSYTPNLARGDPGLATIAKS-------ATIEPKEVKP--------ETKPPEPKKTFNS 415
Query: 486 IAKMDSYARIFFPTAFCLFNLVYWVSYL 513
++K+D +RI FP F +FNLVYW +YL
Sbjct: 416 VSKIDRLSRIAFPLLFGIFNLVYWATYL 443
>gi|189083726 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 357 bits (915), Expect = 2e-98
Identities = 208/508 (40%), Positives = 289/508 (56%), Gaps = 78/508 (15%)
Query: 16 TPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKVPEGDVTVILNNLLE 75
+P S + WILLL +L Q S +D + T V T IL+ LL+
Sbjct: 4 SPGLSDCLWAWILLLSTLTGRSYGQPS---LQDELKDNTTVFTR---------ILDRLLD 51
Query: 76 GYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIKVL 135
GYDN+LRP +G + T + TD++V S GPV+ +MEYTID+FF Q+W D RLKF + VL
Sbjct: 52 GYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVL 111
Query: 136 RLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLH 195
RLN+ M KIW PDTFF N KK+ AH +T PN++LRI DG +LYT+RLT+ AEC + L
Sbjct: 112 RLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLE 171
Query: 196 NFPMDEHSCPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPPTLASRVAGISDGYPR 255
+FPMD H+CPL+F S++ Y R
Sbjct: 172 DFPMDAHACPLKFGSYA----------------------------------------YTR 191
Query: 256 EEIVYQWKRS---SVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRM 312
E+VY+W R SV V + S RL Q+ +G + +V++++G+YVVM+ +F L R++
Sbjct: 192 AEVVYEWTREPARSVVVAEDGS-RLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKI 250
Query: 313 GYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYV 372
GYF IQTY+PC + V+LS VSFW+N+++VPART G+TTVLTMTTLS AR SLPKV+Y
Sbjct: 251 GYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYA 310
Query: 373 TAMDLFVSVCFIFVFSALVEYGTLHYFV------SNRKPSKDKDKKKKNPLLRMFSFKAP 426
TAMD F++VC+ FVFSAL+E+ T++YF + +K KK K+PL++ + AP
Sbjct: 311 TAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAP 370
Query: 427 T-IDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDCRTGAWRHGRIHIR 485
T P A AT + ++ K+ T +
Sbjct: 371 TATSYTPNLARGDPGLATIAKS-------ATIEPKEVKP--------ETKPPEPKKTFNS 415
Query: 486 IAKMDSYARIFFPTAFCLFNLVYWVSYL 513
++K+D +RI FP F +FNLVYW +YL
Sbjct: 416 VSKIDRLSRIAFPLLFGIFNLVYWATYL 443
>gi|189083724 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 357 bits (915), Expect = 2e-98
Identities = 208/508 (40%), Positives = 289/508 (56%), Gaps = 78/508 (15%)
Query: 16 TPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKVPEGDVTVILNNLLE 75
+P S + WILLL +L Q S +D + T V T IL+ LL+
Sbjct: 4 SPGLSDCLWAWILLLSTLTGRSYGQPS---LQDELKDNTTVFTR---------ILDRLLD 51
Query: 76 GYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIKVL 135
GYDN+LRP +G + T + TD++V S GPV+ +MEYTID+FF Q+W D RLKF + VL
Sbjct: 52 GYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVL 111
Query: 136 RLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLH 195
RLN+ M KIW PDTFF N KK+ AH +T PN++LRI DG +LYT+RLT+ AEC + L
Sbjct: 112 RLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLE 171
Query: 196 NFPMDEHSCPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPPTLASRVAGISDGYPR 255
+FPMD H+CPL+F S++ Y R
Sbjct: 172 DFPMDAHACPLKFGSYA----------------------------------------YTR 191
Query: 256 EEIVYQWKRS---SVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRM 312
E+VY+W R SV V + S RL Q+ +G + +V++++G+YVVM+ +F L R++
Sbjct: 192 AEVVYEWTREPARSVVVAEDGS-RLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKI 250
Query: 313 GYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYV 372
GYF IQTY+PC + V+LS VSFW+N+++VPART G+TTVLTMTTLS AR SLPKV+Y
Sbjct: 251 GYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYA 310
Query: 373 TAMDLFVSVCFIFVFSALVEYGTLHYFV------SNRKPSKDKDKKKKNPLLRMFSFKAP 426
TAMD F++VC+ FVFSAL+E+ T++YF + +K KK K+PL++ + AP
Sbjct: 311 TAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAP 370
Query: 427 T-IDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDCRTGAWRHGRIHIR 485
T P A AT + ++ K+ T +
Sbjct: 371 TATSYTPNLARGDPGLATIAKS-------ATIEPKEVKP--------ETKPPEPKKTFNS 415
Query: 486 IAKMDSYARIFFPTAFCLFNLVYWVSYL 513
++K+D +RI FP F +FNLVYW +YL
Sbjct: 416 VSKIDRLSRIAFPLLFGIFNLVYWATYL 443
>gi|38327554 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 357 bits (915), Expect = 2e-98
Identities = 208/508 (40%), Positives = 289/508 (56%), Gaps = 78/508 (15%)
Query: 16 TPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKVPEGDVTVILNNLLE 75
+P S + WILLL +L Q S +D + T V T IL+ LL+
Sbjct: 4 SPGLSDCLWAWILLLSTLTGRSYGQPS---LQDELKDNTTVFTR---------ILDRLLD 51
Query: 76 GYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIKVL 135
GYDN+LRP +G + T + TD++V S GPV+ +MEYTID+FF Q+W D RLKF + VL
Sbjct: 52 GYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVL 111
Query: 136 RLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLH 195
RLN+ M KIW PDTFF N KK+ AH +T PN++LRI DG +LYT+RLT+ AEC + L
Sbjct: 112 RLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLE 171
Query: 196 NFPMDEHSCPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPPTLASRVAGISDGYPR 255
+FPMD H+CPL+F S++ Y R
Sbjct: 172 DFPMDAHACPLKFGSYA----------------------------------------YTR 191
Query: 256 EEIVYQWKRS---SVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRM 312
E+VY+W R SV V + S RL Q+ +G + +V++++G+YVVM+ +F L R++
Sbjct: 192 AEVVYEWTREPARSVVVAEDGS-RLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKI 250
Query: 313 GYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYV 372
GYF IQTY+PC + V+LS VSFW+N+++VPART G+TTVLTMTTLS AR SLPKV+Y
Sbjct: 251 GYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYA 310
Query: 373 TAMDLFVSVCFIFVFSALVEYGTLHYFV------SNRKPSKDKDKKKKNPLLRMFSFKAP 426
TAMD F++VC+ FVFSAL+E+ T++YF + +K KK K+PL++ + AP
Sbjct: 311 TAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAP 370
Query: 427 T-IDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDCRTGAWRHGRIHIR 485
T P A AT + ++ K+ T +
Sbjct: 371 TATSYTPNLARGDPGLATIAKS-------ATIEPKEVKP--------ETKPPEPKKTFNS 415
Query: 486 IAKMDSYARIFFPTAFCLFNLVYWVSYL 513
++K+D +RI FP F +FNLVYW +YL
Sbjct: 416 VSKIDRLSRIAFPLLFGIFNLVYWATYL 443
>gi|34452723 gamma-aminobutyric acid A receptor, alpha 4 precursor
[Homo sapiens]
Length = 554
Score = 346 bits (888), Expect = 3e-95
Identities = 181/387 (46%), Positives = 246/387 (63%), Gaps = 53/387 (13%)
Query: 67 TVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRL 126
T IL++LL+GYDN+LRP G T + TD+YV S GPV+ + MEYT+D+FF QTW D+RL
Sbjct: 49 TRILDSLLDGYDNRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRL 108
Query: 127 KFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTI 186
K++ I++LRLN+ MV K+W PDTFFRN KK+ +H +T PN++ RI +G +LYT+RLTI
Sbjct: 109 KYDGPIEILRLNNMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTI 168
Query: 187 DAECQLQLHNFPMDEHSCPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPPTLASRV 246
AEC ++L +FPMD H+CPL+F S++
Sbjct: 169 SAECPMRLVDFPMDGHACPLKFGSYA---------------------------------- 194
Query: 247 AGISDGYPREEIVYQWKR---SSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMS 303
YP+ E++Y W + SVEV S L Q+ +G ++E +K+ +G+Y+VM+
Sbjct: 195 ------YPKSEMIYTWTKGPEKSVEV-PKESSSLVQYDLIGQTVSSETIKSITGEYIVMT 247
Query: 304 VYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIAR 363
VYF L R+MGYF IQTYIPC + V+LS VSFWINK++VPART GITTVLTMTTLS AR
Sbjct: 248 VYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISAR 307
Query: 364 KSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFV------SNRKPSKDKDKKKKNPL 417
SLPKVSY TAMD F++VCF FVFSAL+E+ ++YF + RK SK + P+
Sbjct: 308 HSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNIQMEKAKRKTSKPPQEVPAAPV 367
Query: 418 LRMFSFKAPTIDIRPRSATIQMNNATH 444
R K P ++ +A + M T+
Sbjct: 368 QRE---KHPEAPLQNTNANLNMRKRTN 391
Score = 42.0 bits (97), Expect = 0.001
Identities = 17/27 (62%), Positives = 20/27 (74%)
Query: 487 AKMDSYARIFFPTAFCLFNLVYWVSYL 513
+K+D YARI FP F FN+VYWV YL
Sbjct: 516 SKIDKYARILFPVTFGAFNMVYWVVYL 542
>gi|4503861 gamma-aminobutyric acid (GABA) A receptor, alpha 5
precursor [Homo sapiens]
Length = 462
Score = 344 bits (882), Expect = 1e-94
Identities = 191/456 (41%), Positives = 269/456 (58%), Gaps = 65/456 (14%)
Query: 67 TVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRL 126
T IL+ LL+GYDN+LRP +G + T + TD+YV S GPV+ MEYTID+FF Q+W D RL
Sbjct: 50 TRILDGLLDGYDNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERL 109
Query: 127 KFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTI 186
+F ++ L LN+ + KIW PDTFF N KK+ AH +TTPN++LR+ +DG +LYT+RLTI
Sbjct: 110 RFKGPMQRLPLNNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTI 169
Query: 187 DAECQLQLHNFPMDEHSCPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPPTLASRV 246
AEC +QL +FPMD H+CPL+F S++
Sbjct: 170 SAECPMQLEDFPMDAHACPLKFGSYA---------------------------------- 195
Query: 247 AGISDGYPREEIVYQW---KRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMS 303
YP E+VY W SV V + S RL Q+ +G TE + T++G+Y +M+
Sbjct: 196 ------YPNSEVVYVWTNGSTKSVVVAEDGS-RLNQYHLMGQTVGTENISTSTGEYTIMT 248
Query: 304 VYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIAR 363
+F L R++GYF IQTY+PC + V+LS VSFW+N+++VPART G+TTVLTMTTLS AR
Sbjct: 249 AHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISAR 308
Query: 364 KSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFV------SNRKPSKDKDKKKKNPL 417
SLPKV+Y TAMD F++VC+ FVFSAL+E+ T++YF +K + KKK +
Sbjct: 309 NSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKKALEAAKIKKKREV 368
Query: 418 LRMFSFKAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDCRTGAW 477
+ S A T T +M++ ++ + G + S + +T
Sbjct: 369 ILNKSTNAFT--------TGKMSHPPNIPKEQTPAG-----TSNTTSVSVKPSEEKTSES 415
Query: 478 RHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYL 513
+ + + I+K+D +RI FP F FNLVYW +YL
Sbjct: 416 K--KTYNSISKIDKMSRIVFPVLFGTFNLVYWATYL 449
>gi|167000817 gamma-aminobutyric acid A receptor, alpha 2 [Homo
sapiens]
Length = 451
Score = 341 bits (875), Expect = 8e-94
Identities = 189/462 (40%), Positives = 266/462 (57%), Gaps = 78/462 (16%)
Query: 67 TVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRL 126
T IL+ LL+GYDN+LRP +G T + T++YV S GPV+ +MEYTID+FF Q W D RL
Sbjct: 43 TRILDRLLDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERL 102
Query: 127 KFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTI 186
KF + +LRLN+ M KIW PDTFF N KK+ AH +T PN++LRI +DG +LYT+RLT+
Sbjct: 103 KFKGPMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTV 162
Query: 187 DAECQLQLHNFPMDEHSCPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPPTLASRV 246
AEC + L +FPMD HSCPL+F S++
Sbjct: 163 QAECPMHLEDFPMDAHSCPLKFGSYA---------------------------------- 188
Query: 247 AGISDGYPREEIVYQW---KRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMS 303
Y E+ Y W SV+V S RL Q+ +G E +K+++G+Y VM+
Sbjct: 189 ------YTTSEVTYIWTYNASDSVQVAPDGS-RLNQYDLLGQSIGKETIKSSTGEYTVMT 241
Query: 304 VYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIAR 363
+F L R++GYF IQTY+PC + V+LS VSFW+N+++VPART G+TTVLTMTTLS AR
Sbjct: 242 AHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISAR 301
Query: 364 KSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFV------SNRKPSKDKDKKKKNPL 417
SLPKV+Y TAMD F++VC+ FVFSAL+E+ T++YF + DK K+K + +
Sbjct: 302 NSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKSVVNDKKKEKASVM 361
Query: 418 LRMFSFK------APTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFED 471
++ ++ AP + P +TI + T E +++ + + K
Sbjct: 362 IQNNAYAVAVANYAPNLSKDPVLSTISKSATT--PEPNKKPENKPAEAK----------- 408
Query: 472 CRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYL 513
+ ++K+D +RI FP F FNLVYW +YL
Sbjct: 409 ---------KTFNSVSKIDRMSRIVFPVLFGTFNLVYWATYL 441
>gi|167000751 gamma-aminobutyric acid A receptor, alpha 2 precursor
[Homo sapiens]
Length = 451
Score = 341 bits (875), Expect = 8e-94
Identities = 189/462 (40%), Positives = 266/462 (57%), Gaps = 78/462 (16%)
Query: 67 TVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRL 126
T IL+ LL+GYDN+LRP +G T + T++YV S GPV+ +MEYTID+FF Q W D RL
Sbjct: 43 TRILDRLLDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERL 102
Query: 127 KFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTI 186
KF + +LRLN+ M KIW PDTFF N KK+ AH +T PN++LRI +DG +LYT+RLT+
Sbjct: 103 KFKGPMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTV 162
Query: 187 DAECQLQLHNFPMDEHSCPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPPTLASRV 246
AEC + L +FPMD HSCPL+F S++
Sbjct: 163 QAECPMHLEDFPMDAHSCPLKFGSYA---------------------------------- 188
Query: 247 AGISDGYPREEIVYQW---KRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMS 303
Y E+ Y W SV+V S RL Q+ +G E +K+++G+Y VM+
Sbjct: 189 ------YTTSEVTYIWTYNASDSVQVAPDGS-RLNQYDLLGQSIGKETIKSSTGEYTVMT 241
Query: 304 VYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIAR 363
+F L R++GYF IQTY+PC + V+LS VSFW+N+++VPART G+TTVLTMTTLS AR
Sbjct: 242 AHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISAR 301
Query: 364 KSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFV------SNRKPSKDKDKKKKNPL 417
SLPKV+Y TAMD F++VC+ FVFSAL+E+ T++YF + DK K+K + +
Sbjct: 302 NSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKSVVNDKKKEKASVM 361
Query: 418 LRMFSFK------APTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFED 471
++ ++ AP + P +TI + T E +++ + + K
Sbjct: 362 IQNNAYAVAVANYAPNLSKDPVLSTISKSATT--PEPNKKPENKPAEAK----------- 408
Query: 472 CRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYL 513
+ ++K+D +RI FP F FNLVYW +YL
Sbjct: 409 ---------KTFNSVSKIDRMSRIVFPVLFGTFNLVYWATYL 441
>gi|194097327 gamma-aminobutyric acid (GABA) A receptor, beta 1
precursor [Homo sapiens]
Length = 474
Score = 275 bits (702), Expect = 9e-74
Identities = 169/489 (34%), Positives = 250/489 (51%), Gaps = 99/489 (20%)
Query: 70 LNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFN 129
++ LL+GYD +LRPD G P + + V SI V+ +NM+YT+ ++F Q+W D+RL ++
Sbjct: 41 VDRLLKGYDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYS 100
Query: 130 STIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAE 189
L L++ + ++W+PDT+F N KK+ H +T NRM+R+ DG VLY LR+T A
Sbjct: 101 GIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAA 160
Query: 190 CQLQLHNFPMDEHSCPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPPTLASRVAGI 249
C + L +P+DE +C LE S+
Sbjct: 161 CMMDLRRYPLDEQNCTLEIESY-------------------------------------- 182
Query: 250 SDGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLS 309
GY ++I + W V L QFS V + ++ V+ T+G Y +S+ F L
Sbjct: 183 --GYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLK 240
Query: 310 RRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKV 369
R +GYF +QTY+P TLI +LSWVSFWIN DA AR +LGITTVLTMTT+ST R++LPK+
Sbjct: 241 RNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKI 300
Query: 370 SYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSK------DKDKKKKNPL-LRMFS 422
YV A+D+++ CF+FVF AL+EY ++Y + P K D+ +KN L +
Sbjct: 301 PYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQKKGASKQDQSANEKNKLEMNKVQ 360
Query: 423 FKA------PTIDIRPRS-------------ATIQMNNATHLQERD-----EEYGYECLD 458
A T++IR + AT+ ++ +Q R E YG LD
Sbjct: 361 VDAHGNILLSTLEIRNETSGSEVLTSVSDPKATMYSYDSASIQYRKPLSSREAYG-RALD 419
Query: 459 GKDCASFFCCFEDCRTGAWRHGRIHIRIAKM-------------DSYARIFFPTAFCLFN 505
R G GRI R +++ D ++R+FFP F LFN
Sbjct: 420 --------------RHGVPSKGRIRRRASQLKVKIPDLTDVNSIDKWSRMFFPITFSLFN 465
Query: 506 LVYWVSYLY 514
+VYW+ Y++
Sbjct: 466 VVYWLYYVH 474
>gi|4503865 gamma-aminobutyric acid (GABA) A receptor, beta 2
isoform 2 [Homo sapiens]
Length = 474
Score = 271 bits (693), Expect = 1e-72
Identities = 164/489 (33%), Positives = 248/489 (50%), Gaps = 100/489 (20%)
Query: 70 LNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFN 129
++ LL+GYD +LRPD G P + ++ + SI V+ +NM+YT+ ++F Q W D+RL +N
Sbjct: 40 VDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYN 99
Query: 130 STIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAE 189
L L++ + ++W+PDT+F N KK+ H +T NRM+R+ DG VLY LR+T A
Sbjct: 100 VIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAA 159
Query: 190 CQLQLHNFPMDEHSCPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPPTLASRVAGI 249
C + L +P+DE +C LE S+
Sbjct: 160 CMMDLRRYPLDEQNCTLEIESY-------------------------------------- 181
Query: 250 SDGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLS 309
GY ++I + W+ V L QFS V + T+ V ++G Y +S+ F L
Sbjct: 182 --GYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLK 239
Query: 310 RRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKV 369
R +GYF +QTY+P LI +LSWVSFWIN DA AR +LGITTVLTMTT++T R++LPK+
Sbjct: 240 RNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI 299
Query: 370 SYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKK-----NPLLRMFSFK 424
YV A+D+++ CF+FVF AL+EY ++Y R P + K +K N +R+ K
Sbjct: 300 PYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAASANNEKMRLDVNK 359
Query: 425 --------APTIDIR--------------PRSATIQMNNATHLQERD-----EEYGYECL 457
T++I+ PRS T+ +A+ +Q R +G L
Sbjct: 360 MDPHENILLSTLEIKNEMATSEAVMGLGDPRS-TMLAYDASSIQYRKAGLPRHSFGRNAL 418
Query: 458 DGKDCASFFCCFEDCRTGAWRHGRIHIRIAKM-------------DSYARIFFPTAFCLF 504
+ R A + R+ R +++ D ++RIFFP F F
Sbjct: 419 E--------------RHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFF 464
Query: 505 NLVYWVSYL 513
N+VYW+ Y+
Sbjct: 465 NIVYWLYYV 473
>gi|12548788 gamma-aminobutyric acid (GABA) A receptor, beta 3
isoform 2 precursor [Homo sapiens]
Length = 473
Score = 265 bits (677), Expect = 7e-71
Identities = 157/477 (32%), Positives = 238/477 (49%), Gaps = 78/477 (16%)
Query: 70 LNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFN 129
++ LL+GYD +LRPD G P + ++ + SI V+ +NM+YT+ ++F Q W D+RL ++
Sbjct: 41 VDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYS 100
Query: 130 STIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAE 189
L L++ + ++W+PDT+F N KK+ H +T NRM+R+ DG VLY LR+T A
Sbjct: 101 GIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAA 160
Query: 190 CQLQLHNFPMDEHSCPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPPTLASRVAGI 249
C + L +P+DE +C LE S+
Sbjct: 161 CMMDLRRYPLDEQNCTLEIESY-------------------------------------- 182
Query: 250 SDGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLS 309
GY ++I + W+ V L QFS V R + V +G Y +S+ F L
Sbjct: 183 --GYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLK 240
Query: 310 RRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKV 369
R +GYF +QTY+P LI +LSWVSFWIN DA AR +LGITTVLTMTT++T R++LPK+
Sbjct: 241 RNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI 300
Query: 370 SYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKKNPLLRMFSFKAPTID 429
YV A+D+++ CF+FVF AL+EY ++Y R P + K +K + K+ +
Sbjct: 301 PYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNR 360
Query: 430 IRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDC----------RTGAWR- 478
+ + + H + + G D + F++ R G R
Sbjct: 361 VDAHGNILLTSLEVHNEMNEVSGGI-----GDTRNSAISFDNSGIQYRKQSMPREGHGRF 415
Query: 479 -------HGRIHIR---------------IAKMDSYARIFFPTAFCLFNLVYWVSYL 513
H + H+R + +D ++RI FP F LFNLVYW+ Y+
Sbjct: 416 LGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYYV 472
>gi|4503867 gamma-aminobutyric acid (GABA) A receptor, beta 3
isoform 1 precursor [Homo sapiens]
Length = 473
Score = 265 bits (677), Expect = 7e-71
Identities = 157/477 (32%), Positives = 238/477 (49%), Gaps = 78/477 (16%)
Query: 70 LNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFN 129
++ LL+GYD +LRPD G P + ++ + SI V+ +NM+YT+ ++F Q W D+RL ++
Sbjct: 41 VDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYS 100
Query: 130 STIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAE 189
L L++ + ++W+PDT+F N KK+ H +T NRM+R+ DG VLY LR+T A
Sbjct: 101 GIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAA 160
Query: 190 CQLQLHNFPMDEHSCPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPPTLASRVAGI 249
C + L +P+DE +C LE S+
Sbjct: 161 CMMDLRRYPLDEQNCTLEIESY-------------------------------------- 182
Query: 250 SDGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLS 309
GY ++I + W+ V L QFS V R + V +G Y +S+ F L
Sbjct: 183 --GYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLK 240
Query: 310 RRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKV 369
R +GYF +QTY+P LI +LSWVSFWIN DA AR +LGITTVLTMTT++T R++LPK+
Sbjct: 241 RNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI 300
Query: 370 SYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKKNPLLRMFSFKAPTID 429
YV A+D+++ CF+FVF AL+EY ++Y R P + K +K + K+ +
Sbjct: 301 PYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNR 360
Query: 430 IRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDC----------RTGAWR- 478
+ + + H + + G D + F++ R G R
Sbjct: 361 VDAHGNILLTSLEVHNEMNEVSGGI-----GDTRNSAISFDNSGIQYRKQSMPREGHGRF 415
Query: 479 -------HGRIHIR---------------IAKMDSYARIFFPTAFCLFNLVYWVSYL 513
H + H+R + +D ++RI FP F LFNLVYW+ Y+
Sbjct: 416 LGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYYV 472
>gi|34734071 gamma-aminobutyric acid (GABA) A receptor, delta
precursor [Homo sapiens]
Length = 452
Score = 264 bits (674), Expect = 2e-70
Identities = 161/456 (35%), Positives = 229/456 (50%), Gaps = 62/456 (13%)
Query: 70 LNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFN 129
L+ L+ GY RP IG P + + V SI ++ NMEYT+ +F Q+W D RL +N
Sbjct: 44 LDGLIAGYARNFRPGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYN 103
Query: 130 STIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAE 189
T + L L+S V K+W+PDTF N+K A H +T N+++R+ DG +LY++R+T
Sbjct: 104 HTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVA 163
Query: 190 CQLQLHNFPMDEHSCPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPPTLASRVAGI 249
C + L +PMDE C L+ S+
Sbjct: 164 CDMDLAKYPMDEQECMLDLESY-------------------------------------- 185
Query: 250 SDGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTS-GDYVVMSVYFDL 308
GY E+IVY W S + +L QF+ R TTE++ S G + +S++F L
Sbjct: 186 --GYSSEDIVYYWSESQEHIHGLDKLQLAQFTITSYRFTTELMNFKSAGQFPRLSLHFHL 243
Query: 309 SRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPK 368
R G + IQ+Y+P L+V +SWVSFWI++ AVPAR SLGITTVLTMTTL AR SLP+
Sbjct: 244 RRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVSLGITTVLTMTTLMVSARSSLPR 303
Query: 369 VSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKKNPLLRMFSFKAPTI 428
S + A+D++ +C++FVF+ALVEY H+ RK K K K + P M
Sbjct: 304 ASAIKALDVYFWICYVFVFAALVEYAFAHFNADYRKKQKAKVKVSR-PRAEM-------- 354
Query: 429 DIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFC----CFEDCRTGAWR---HGR 481
D+R ++ A QE + G S+ E + GA R G
Sbjct: 355 DVRNAIVLFSLSAAGVTQELAISRRQRRVPGNLMGSYRSVGVETGETKKEGAARSGGQGG 414
Query: 482 IHIRIAKMDS-----YARIFFPTAFCLFNLVYWVSY 512
I R+ +D+ YAR FP AF N++YW +Y
Sbjct: 415 IRARLRPIDADTIDIYARAVFPAAFAAVNVIYWAAY 450
>gi|12548785 gamma-aminobutyric acid (GABA) A receptor, beta 2
isoform 1 [Homo sapiens]
Length = 512
Score = 260 bits (665), Expect = 2e-69
Identities = 133/345 (38%), Positives = 196/345 (56%), Gaps = 40/345 (11%)
Query: 70 LNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFN 129
++ LL+GYD +LRPD G P + ++ + SI V+ +NM+YT+ ++F Q W D+RL +N
Sbjct: 40 VDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYN 99
Query: 130 STIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAE 189
L L++ + ++W+PDT+F N KK+ H +T NRM+R+ DG VLY LR+T A
Sbjct: 100 VIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAA 159
Query: 190 CQLQLHNFPMDEHSCPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPPTLASRVAGI 249
C + L +P+DE +C LE S+
Sbjct: 160 CMMDLRRYPLDEQNCTLEIESY-------------------------------------- 181
Query: 250 SDGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLS 309
GY ++I + W+ V L QFS V + T+ V ++G Y +S+ F L
Sbjct: 182 --GYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLK 239
Query: 310 RRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKV 369
R +GYF +QTY+P LI +LSWVSFWIN DA AR +LGITTVLTMTT++T R++LPK+
Sbjct: 240 RNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI 299
Query: 370 SYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKK 414
YV A+D+++ CF+FVF AL+EY ++Y R P + K +K
Sbjct: 300 PYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEK 344
Score = 37.4 bits (85), Expect = 0.033
Identities = 13/25 (52%), Positives = 19/25 (76%)
Query: 489 MDSYARIFFPTAFCLFNLVYWVSYL 513
+D ++RIFFP F FN+VYW+ Y+
Sbjct: 487 IDRWSRIFFPVVFSFFNIVYWLYYV 511
>gi|225903367 glycine receptor, alpha 1 isoform 1 precursor [Homo
sapiens]
Length = 457
Score = 246 bits (627), Expect = 5e-65
Identities = 156/454 (34%), Positives = 229/454 (50%), Gaps = 75/454 (16%)
Query: 76 GYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNS-TIKV 134
GYD ++RP+ P + ++++NS G + M+Y ++IF Q W D RL +N
Sbjct: 51 GYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDS 110
Query: 135 LRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQL 194
L L+ +M+ IW PD FF N K A H ITT N++LRI +G VLY++R+T+ C + L
Sbjct: 111 LDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDL 170
Query: 195 HNFPMDEHSCPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPPTLASRVAGISDGYP 254
NFPMD +C ++ S+ GY
Sbjct: 171 KNFPMDVQTCIMQLESF----------------------------------------GYT 190
Query: 255 REEIVYQWK-RSSVEVGDTRSWRLYQFSFVGLRNTTEVVKT-TSGDYVVMSVYFDLSRRM 312
+++++W+ + +V+V D + L QF ++ K +G + + F L R+M
Sbjct: 191 MNDLIFEWQEQGAVQVADGLT--LPQFILKEEKDLRYCTKHYNTGKFTCIEARFHLERQM 248
Query: 313 GYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYV 372
GY+ IQ YIP LIV+LSW+SFWIN DA PAR LGITTVLTMTT S+ +R SLPKVSYV
Sbjct: 249 GYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYV 308
Query: 373 TAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKP---SKDKDKKKKNPLLRMFSFKAPTID 429
A+D++++VC +FVFSAL+EY +++ K + K + K+P+L +F
Sbjct: 309 KAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKSPMLNLF-------- 360
Query: 430 IRPRSATIQMNNATHLQERDEEYGY--ECLDGKDCASFFCCFEDCRT--------GAWRH 479
Q + A + YG CL KD S T
Sbjct: 361 --------QEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEM 412
Query: 480 GRIHI-RIAKMDSYARIFFPTAFCLFNLVYWVSY 512
++ I R K+D +RI FP AF +FN+ YW+ Y
Sbjct: 413 RKLFIQRAKKIDKISRIGFPMAFLIFNMFYWIIY 446
>gi|110347441 glycine receptor, alpha 3 isoform a [Homo sapiens]
Length = 464
Score = 242 bits (617), Expect = 7e-64
Identities = 156/466 (33%), Positives = 230/466 (49%), Gaps = 93/466 (19%)
Query: 76 GYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNS-TIKV 134
GYD ++RP+ P + ++++NS G + M+Y ++IF Q W D RL ++
Sbjct: 56 GYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDS 115
Query: 135 LRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQL 194
L L+ +M+ IW PD FF N K A+ H +TT N++LRI+ +G VLY++RLT+ C + L
Sbjct: 116 LDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDL 175
Query: 195 HNFPMDEHSCPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPPTLASRVAGISDGYP 254
NFPMD +C ++ S+ GY
Sbjct: 176 KNFPMDVQTCIMQLESF----------------------------------------GYT 195
Query: 255 REEIVYQWK-RSSVEVGDTRSWRLYQFSFVGLRNTTEVVKT-TSGDYVVMSVYFDLSRRM 312
+++++W+ + V+V + + L QF ++ K +G + + V F L R+M
Sbjct: 196 MNDLIFEWQDEAPVQVAEGLT--LPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQM 253
Query: 313 GYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYV 372
GY+ IQ YIP LIV+LSWVSFWIN DA PAR +LGITTVLTMTT S+ +R SLPKVSYV
Sbjct: 254 GYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYV 313
Query: 373 TAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKP-----SKDKDKKKKNPLLRMFSFKAPT 427
A+D++++VC +FVFSAL+EY +++ K K K+K + L + + F
Sbjct: 314 KAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRKNKTEAFALEKFYRFSDMD 373
Query: 428 IDIRPRSATIQMNNATHLQERDEEYGY-ECLDGKDCASFFCCFEDCRTGAWRHGRIH--- 483
++R + YG CL KD G G H
Sbjct: 374 DEVRESRFSF------------TAYGMGPCLQAKD-------------GMTPKGPNHPVQ 408
Query: 484 --------------IRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL 515
R K+D+ +R FP AF +FN+ YWV Y L
Sbjct: 409 VMPKSPDEMRKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIYKIL 454
>gi|110347433 glycine receptor, alpha 3 isoform b [Homo sapiens]
Length = 449
Score = 241 bits (616), Expect = 9e-64
Identities = 152/452 (33%), Positives = 228/452 (50%), Gaps = 80/452 (17%)
Query: 76 GYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNS-TIKV 134
GYD ++RP+ P + ++++NS G + M+Y ++IF Q W D RL ++
Sbjct: 56 GYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDS 115
Query: 135 LRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQL 194
L L+ +M+ IW PD FF N K A+ H +TT N++LRI+ +G VLY++RLT+ C + L
Sbjct: 116 LDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDL 175
Query: 195 HNFPMDEHSCPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPPTLASRVAGISDGYP 254
NFPMD +C ++ S+ GY
Sbjct: 176 KNFPMDVQTCIMQLESF----------------------------------------GYT 195
Query: 255 REEIVYQWK-RSSVEVGDTRSWRLYQFSFVGLRNTTEVVKT-TSGDYVVMSVYFDLSRRM 312
+++++W+ + V+V + + L QF ++ K +G + + V F L R+M
Sbjct: 196 MNDLIFEWQDEAPVQVAEGLT--LPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQM 253
Query: 313 GYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYV 372
GY+ IQ YIP LIV+LSWVSFWIN DA PAR +LGITTVLTMTT S+ +R SLPKVSYV
Sbjct: 254 GYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYV 313
Query: 373 TAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKKNP----LLRMFSFKA--- 425
A+D++++VC +FVFSAL+EY +++ K +K+KN FSF A
Sbjct: 314 KAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRKNKDDEVRESRFSFTAYGM 373
Query: 426 -PTIDIRPRSATIQMNNATHLQERD-EEYGYECLDGKDCASFFCCFEDCRTGAWRHGRIH 483
P + + N+ + + +E +D
Sbjct: 374 GPCLQAKDGMTPKGPNHPVQVMPKSPDEMRKVFID------------------------- 408
Query: 484 IRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL 515
R K+D+ +R FP AF +FN+ YWV Y L
Sbjct: 409 -RAKKIDTISRACFPLAFLIFNIFYWVIYKIL 439
>gi|169646723 glycine receptor, alpha 2 isoform A [Homo sapiens]
Length = 452
Score = 238 bits (607), Expect = 1e-62
Identities = 150/452 (33%), Positives = 225/452 (49%), Gaps = 82/452 (18%)
Query: 76 GYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNS-TIKV 134
GYD ++RP+ P + ++++NS G V M+Y ++IF Q W D RL ++
Sbjct: 57 GYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPDDS 116
Query: 135 LRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQL 194
L L+ +M+ IW PD FF N K A+ H +TT N++LRI +G+VLY++RLT+ C + L
Sbjct: 117 LDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDL 176
Query: 195 HNFPMDEHSCPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPPTLASRVAGISDGYP 254
NFPMD +C ++ S+ GY
Sbjct: 177 KNFPMDVQTCTMQLESF----------------------------------------GYT 196
Query: 255 REEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKT-TSGDYVVMSVYFDLSRRMG 313
+++++W S V L QF + K +G + + V F L R+MG
Sbjct: 197 MNDLIFEWL-SDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMG 255
Query: 314 YFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVT 373
Y+ IQ YIP LIV+LSWVSFWIN DA PAR +LGITTVLTMTT S+ +R SLPKVSYV
Sbjct: 256 YYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVK 315
Query: 374 AMDLFVSVCFIFVFSALVEYGTLHY-------FVSNRKPSKDKDKKKKNPLLRMFSFKAP 426
A+D++++VC +FVF+AL+EY +++ F+ R+ K ++K++ F+F
Sbjct: 316 AIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSG- 374
Query: 427 TIDIRPRSATIQMNNATHLQERDEEYGY-ECLDGKDCASFFC-----CFEDCRTGAWRHG 480
YG CL KD + + + G
Sbjct: 375 -------------------------YGMGHCLQVKDGTAVKATPANPLPQPPKDGDAIKK 409
Query: 481 RIHIRIAKMDSYARIFFPTAFCLFNLVYWVSY 512
+ R ++D+ +R FP AF +FN+ YW++Y
Sbjct: 410 KFVDRAKRIDTISRAAFPLAFLIFNIFYWITY 441
>gi|4504021 glycine receptor, alpha 2 isoform A [Homo sapiens]
Length = 452
Score = 238 bits (607), Expect = 1e-62
Identities = 150/452 (33%), Positives = 225/452 (49%), Gaps = 82/452 (18%)
Query: 76 GYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNS-TIKV 134
GYD ++RP+ P + ++++NS G V M+Y ++IF Q W D RL ++
Sbjct: 57 GYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPDDS 116
Query: 135 LRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQL 194
L L+ +M+ IW PD FF N K A+ H +TT N++LRI +G+VLY++RLT+ C + L
Sbjct: 117 LDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDL 176
Query: 195 HNFPMDEHSCPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPPTLASRVAGISDGYP 254
NFPMD +C ++ S+ GY
Sbjct: 177 KNFPMDVQTCTMQLESF----------------------------------------GYT 196
Query: 255 REEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKT-TSGDYVVMSVYFDLSRRMG 313
+++++W S V L QF + K +G + + V F L R+MG
Sbjct: 197 MNDLIFEWL-SDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMG 255
Query: 314 YFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVT 373
Y+ IQ YIP LIV+LSWVSFWIN DA PAR +LGITTVLTMTT S+ +R SLPKVSYV
Sbjct: 256 YYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVK 315
Query: 374 AMDLFVSVCFIFVFSALVEYGTLHY-------FVSNRKPSKDKDKKKKNPLLRMFSFKAP 426
A+D++++VC +FVF+AL+EY +++ F+ R+ K ++K++ F+F
Sbjct: 316 AIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSG- 374
Query: 427 TIDIRPRSATIQMNNATHLQERDEEYGY-ECLDGKDCASFFC-----CFEDCRTGAWRHG 480
YG CL KD + + + G
Sbjct: 375 -------------------------YGMGHCLQVKDGTAVKATPANPLPQPPKDGDAIKK 409
Query: 481 RIHIRIAKMDSYARIFFPTAFCLFNLVYWVSY 512
+ R ++D+ +R FP AF +FN+ YW++Y
Sbjct: 410 KFVDRAKRIDTISRAAFPLAFLIFNIFYWITY 441
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.136 0.433
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,423,500
Number of Sequences: 37866
Number of extensions: 831701
Number of successful extensions: 2376
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 86
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 2156
Number of HSP's gapped (non-prelim): 175
length of query: 515
length of database: 18,247,518
effective HSP length: 107
effective length of query: 408
effective length of database: 14,195,856
effective search space: 5791909248
effective search space used: 5791909248
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.