Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 189027048

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|189027048 ecto-NOX disulfide-thiol exchanger 1 [Homo
sapiens]
         (643 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|189027048 ecto-NOX disulfide-thiol exchanger 1 [Homo sapiens]     1285   0.0  
gi|189027046 ecto-NOX disulfide-thiol exchanger 1 [Homo sapiens]     1285   0.0  
gi|32528291 ecto-NOX disulfide-thiol exchanger 2 isoform b [Homo...   836   0.0  
gi|32528293 ecto-NOX disulfide-thiol exchanger 2 isoform a [Homo...   826   0.0  
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik...    65   3e-10
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa...    64   4e-10
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa...    63   1e-09
gi|34577114 cytomatrix protein p110 [Homo sapiens]                     61   3e-09
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi...    60   6e-09
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li...    60   8e-09
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m...    58   2e-08
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m...    58   2e-08
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li...    58   3e-08
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap...    57   5e-08
gi|45439327 periplakin [Homo sapiens]                                  57   7e-08
gi|114155142 nuclear pore complex-associated protein TPR [Homo s...    55   2e-07
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     55   2e-07
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]    55   2e-07
gi|148746195 trichohyalin [Homo sapiens]                               55   2e-07
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa...    55   2e-07
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...    55   2e-07
gi|21735548 centrosomal protein 2 [Homo sapiens]                       55   3e-07
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        54   4e-07
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        54   4e-07
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         54   4e-07
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         54   4e-07
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         54   4e-07
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         54   4e-07
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         54   4e-07
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         54   4e-07

>gi|189027048 ecto-NOX disulfide-thiol exchanger 1 [Homo sapiens]
          Length = 643

 Score = 1285 bits (3326), Expect = 0.0
 Identities = 643/643 (100%), Positives = 643/643 (100%)

Query: 1   MVDAGGVENITQLPQELPQMMAAAADGLGSIAIDTTQLNMSVTDPTAWATAMNNLGMVPV 60
           MVDAGGVENITQLPQELPQMMAAAADGLGSIAIDTTQLNMSVTDPTAWATAMNNLGMVPV
Sbjct: 1   MVDAGGVENITQLPQELPQMMAAAADGLGSIAIDTTQLNMSVTDPTAWATAMNNLGMVPV 60

Query: 61  GLPGQQLVSDSICVPGFDPSLNMMTGITPINPMIPGLGLVPPPPPTEVAVVKEIIHCKSC 120
           GLPGQQLVSDSICVPGFDPSLNMMTGITPINPMIPGLGLVPPPPPTEVAVVKEIIHCKSC
Sbjct: 61  GLPGQQLVSDSICVPGFDPSLNMMTGITPINPMIPGLGLVPPPPPTEVAVVKEIIHCKSC 120

Query: 121 TLFPQNPNLPPPSTRERPPGCKTVFVGGLPENATEEIIQEVFEQCGDITAIRKSKKNFCH 180
           TLFPQNPNLPPPSTRERPPGCKTVFVGGLPENATEEIIQEVFEQCGDITAIRKSKKNFCH
Sbjct: 121 TLFPQNPNLPPPSTRERPPGCKTVFVGGLPENATEEIIQEVFEQCGDITAIRKSKKNFCH 180

Query: 181 IRFAEEFMVDKAIYLSGYRMRLGSSTDKKDSGRLHVDFAQARDDFYEWECKQRMRAREER 240
           IRFAEEFMVDKAIYLSGYRMRLGSSTDKKDSGRLHVDFAQARDDFYEWECKQRMRAREER
Sbjct: 181 IRFAEEFMVDKAIYLSGYRMRLGSSTDKKDSGRLHVDFAQARDDFYEWECKQRMRAREER 240

Query: 241 HRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSA 300
           HRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSA
Sbjct: 241 HRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSA 300

Query: 301 NQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQK 360
           NQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQK
Sbjct: 301 NQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQK 360

Query: 361 AWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDES 420
           AWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDES
Sbjct: 361 AWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDES 420

Query: 421 ALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGM 480
           ALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGM
Sbjct: 421 ALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGM 480

Query: 481 QQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEIN 540
           QQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEIN
Sbjct: 481 QQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEIN 540

Query: 541 VLTVALVNQDRENNIEKRSQGLKSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQLDSK 600
           VLTVALVNQDRENNIEKRSQGLKSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQLDSK
Sbjct: 541 VLTVALVNQDRENNIEKRSQGLKSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQLDSK 600

Query: 601 ISANEIEMLLMRLPRMFKQEFTGVGATLEKRWKLCAFEGIKTT 643
           ISANEIEMLLMRLPRMFKQEFTGVGATLEKRWKLCAFEGIKTT
Sbjct: 601 ISANEIEMLLMRLPRMFKQEFTGVGATLEKRWKLCAFEGIKTT 643


>gi|189027046 ecto-NOX disulfide-thiol exchanger 1 [Homo sapiens]
          Length = 643

 Score = 1285 bits (3326), Expect = 0.0
 Identities = 643/643 (100%), Positives = 643/643 (100%)

Query: 1   MVDAGGVENITQLPQELPQMMAAAADGLGSIAIDTTQLNMSVTDPTAWATAMNNLGMVPV 60
           MVDAGGVENITQLPQELPQMMAAAADGLGSIAIDTTQLNMSVTDPTAWATAMNNLGMVPV
Sbjct: 1   MVDAGGVENITQLPQELPQMMAAAADGLGSIAIDTTQLNMSVTDPTAWATAMNNLGMVPV 60

Query: 61  GLPGQQLVSDSICVPGFDPSLNMMTGITPINPMIPGLGLVPPPPPTEVAVVKEIIHCKSC 120
           GLPGQQLVSDSICVPGFDPSLNMMTGITPINPMIPGLGLVPPPPPTEVAVVKEIIHCKSC
Sbjct: 61  GLPGQQLVSDSICVPGFDPSLNMMTGITPINPMIPGLGLVPPPPPTEVAVVKEIIHCKSC 120

Query: 121 TLFPQNPNLPPPSTRERPPGCKTVFVGGLPENATEEIIQEVFEQCGDITAIRKSKKNFCH 180
           TLFPQNPNLPPPSTRERPPGCKTVFVGGLPENATEEIIQEVFEQCGDITAIRKSKKNFCH
Sbjct: 121 TLFPQNPNLPPPSTRERPPGCKTVFVGGLPENATEEIIQEVFEQCGDITAIRKSKKNFCH 180

Query: 181 IRFAEEFMVDKAIYLSGYRMRLGSSTDKKDSGRLHVDFAQARDDFYEWECKQRMRAREER 240
           IRFAEEFMVDKAIYLSGYRMRLGSSTDKKDSGRLHVDFAQARDDFYEWECKQRMRAREER
Sbjct: 181 IRFAEEFMVDKAIYLSGYRMRLGSSTDKKDSGRLHVDFAQARDDFYEWECKQRMRAREER 240

Query: 241 HRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSA 300
           HRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSA
Sbjct: 241 HRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSA 300

Query: 301 NQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQK 360
           NQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQK
Sbjct: 301 NQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQK 360

Query: 361 AWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDES 420
           AWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDES
Sbjct: 361 AWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDES 420

Query: 421 ALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGM 480
           ALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGM
Sbjct: 421 ALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGM 480

Query: 481 QQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEIN 540
           QQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEIN
Sbjct: 481 QQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEIN 540

Query: 541 VLTVALVNQDRENNIEKRSQGLKSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQLDSK 600
           VLTVALVNQDRENNIEKRSQGLKSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQLDSK
Sbjct: 541 VLTVALVNQDRENNIEKRSQGLKSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQLDSK 600

Query: 601 ISANEIEMLLMRLPRMFKQEFTGVGATLEKRWKLCAFEGIKTT 643
           ISANEIEMLLMRLPRMFKQEFTGVGATLEKRWKLCAFEGIKTT
Sbjct: 601 ISANEIEMLLMRLPRMFKQEFTGVGATLEKRWKLCAFEGIKTT 643


>gi|32528291 ecto-NOX disulfide-thiol exchanger 2 isoform b [Homo
           sapiens]
          Length = 610

 Score =  836 bits (2159), Expect = 0.0
 Identities = 410/622 (65%), Positives = 503/622 (80%), Gaps = 29/622 (4%)

Query: 24  AADGLGSIAIDTTQLNMSVTDPTAWATAMNNLGMVPVGLPGQQLVSDSICVPGFDPSLNM 83
           AAD   ++ +D+T + + ++DPTAWATAMNNLGM P+G+ GQ ++      P FDP+L M
Sbjct: 16  AADNSRTLNVDSTAMTLPMSDPTAWATAMNNLGMAPLGIAGQPIL------PDFDPALGM 69

Query: 84  MTGITPINPMIPGLGLVPPPPPTEVAVVKEIIHCKSCTLFPQNPNLPPPSTRERPPGCKT 143
           MTGI PI PM+PGLG+VPPP P ++ VVKEIIHCKSCTLFP NPNLPPP+TRERPPGCKT
Sbjct: 70  MTGIPPITPMMPGLGIVPPPIPPDMPVVKEIIHCKSCTLFPPNPNLPPPATRERPPGCKT 129

Query: 144 VFVGGLPENATEEIIQEVFEQCGDITAIRKSKKNFCHIRFAEEFMVDKAIYLSGYRMRLG 203
           VFVGGLPEN TE+II EVFEQCG+I AIRKSKKNFCHIRFAEE+MVDKA+YLSGYR+RLG
Sbjct: 130 VFVGGLPENGTEQIIVEVFEQCGEIIAIRKSKKNFCHIRFAEEYMVDKALYLSGYRIRLG 189

Query: 204 SSTDKKDSGRLHVDFAQARDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSE 263
           SSTDKKD+GRLHVDFAQARDD YEWECKQRM AREERHRR++EE+RLRPPSPP ++HYS+
Sbjct: 190 SSTDKKDTGRLHVDFAQARDDLYEWECKQRMLAREERHRRRMEEERLRPPSPPPVVHYSD 249

Query: 264 HEAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKAT 323
           HE +++AEKLKDDSKFSEA+  LL+WIERGEVNRRSAN FYSM+QSANSHVRRL+NEKA 
Sbjct: 250 HECSIVAEKLKDDSKFSEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAA 309

Query: 324 HEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEEL 383
           HE++MEEAKE FK AL+GIL QFEQIVAV++++++QKAWDHF+KAQRKNI +W K +EE+
Sbjct: 310 HEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEI 369

Query: 384 RNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAY 443
           RN  +++LMGIRREEEMEMSDDE  +  T+    +ESAL +QA ALKEENDSLRWQLDAY
Sbjct: 370 RNIHNDELMGIRREEEMEMSDDE-IEEMTETKETEESALVSQAEALKEENDSLRWQLDAY 428

Query: 444 RNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKE 503
           RNEVELLKQE+ ++ R E++  K+QQL+ LQQ +QGMQQ LL +QEE   K++ELE+ K+
Sbjct: 429 RNEVELLKQEQGKVHR-EDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKD 487

Query: 504 EQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEK--RSQG 561
           ++   + +L+ L+E+      L  +                   NQD E  +EK   S  
Sbjct: 488 DKLQVEKMLENLKEKESCASRLCAS-------------------NQDSEYPLEKTMNSSP 528

Query: 562 LKSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQLDSKISANEIEMLLMRLPRMFKQEF 621
           +KSE+EALL+GIISTFLHVHPFGA+IEY+ SY+ +LD+KI  +++E L+ RL   FKQE 
Sbjct: 529 IKSEREALLVGIISTFLHVHPFGASIEYICSYLHRLDNKICTSDVECLMGRLQHTFKQEM 588

Query: 622 TGVGATLEKRWKLCAFEGIKTT 643
           TGVGA+LEKRWK C FEG+K T
Sbjct: 589 TGVGASLEKRWKFCGFEGLKLT 610


>gi|32528293 ecto-NOX disulfide-thiol exchanger 2 isoform a [Homo
           sapiens]
          Length = 581

 Score =  826 bits (2134), Expect = 0.0
 Identities = 405/608 (66%), Positives = 494/608 (81%), Gaps = 29/608 (4%)

Query: 38  LNMSVTDPTAWATAMNNLGMVPVGLPGQQLVSDSICVPGFDPSLNMMTGITPINPMIPGL 97
           + + ++DPTAWATAMNNLGM P+G+ GQ ++      P FDP+L MMTGI PI PM+PGL
Sbjct: 1   MTLPMSDPTAWATAMNNLGMAPLGIAGQPIL------PDFDPALGMMTGIPPITPMMPGL 54

Query: 98  GLVPPPPPTEVAVVKEIIHCKSCTLFPQNPNLPPPSTRERPPGCKTVFVGGLPENATEEI 157
           G+VPPP P ++ VVKEIIHCKSCTLFP NPNLPPP+TRERPPGCKTVFVGGLPEN TE+I
Sbjct: 55  GIVPPPIPPDMPVVKEIIHCKSCTLFPPNPNLPPPATRERPPGCKTVFVGGLPENGTEQI 114

Query: 158 IQEVFEQCGDITAIRKSKKNFCHIRFAEEFMVDKAIYLSGYRMRLGSSTDKKDSGRLHVD 217
           I EVFEQCG+I AIRKSKKNFCHIRFAEE+MVDKA+YLSGYR+RLGSSTDKKD+GRLHVD
Sbjct: 115 IVEVFEQCGEIIAIRKSKKNFCHIRFAEEYMVDKALYLSGYRIRLGSSTDKKDTGRLHVD 174

Query: 218 FAQARDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDS 277
           FAQARDD YEWECKQRM AREERHRR++EE+RLRPPSPP ++HYS+HE +++AEKLKDDS
Sbjct: 175 FAQARDDLYEWECKQRMLAREERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDS 234

Query: 278 KFSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKN 337
           KFSEA+  LL+WIERGEVNRRSAN FYSM+QSANSHVRRL+NEKA HE++MEEAKE FK 
Sbjct: 235 KFSEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQ 294

Query: 338 ALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRRE 397
           AL+GIL QFEQIVAV++++++QKAWDHF+KAQRKNI +W K +EE+RN  +++LMGIRRE
Sbjct: 295 ALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGIRRE 354

Query: 398 EEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQL 457
           EEMEMSDDE  +  T+    +ESAL +QA ALKEENDSLRWQLDAYRNEVELLKQE+ ++
Sbjct: 355 EEMEMSDDE-IEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKV 413

Query: 458 FRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQE 517
            R E++  K+QQL+ LQQ +QGMQQ LL +QEE   K++ELE+ K+++   + +L+ L+E
Sbjct: 414 HR-EDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKE 472

Query: 518 QLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEK--RSQGLKSEKEALLIGIIS 575
           +      L  +                   NQD E  +EK   S  +KSE+EALL+GIIS
Sbjct: 473 KESCASRLCAS-------------------NQDSEYPLEKTMNSSPIKSEREALLVGIIS 513

Query: 576 TFLHVHPFGANIEYLWSYMQQLDSKISANEIEMLLMRLPRMFKQEFTGVGATLEKRWKLC 635
           TFLHVHPFGA+IEY+ SY+ +LD+KI  +++E L+ RL   FKQE TGVGA+LEKRWK C
Sbjct: 514 TFLHVHPFGASIEYICSYLHRLDNKICTSDVECLMGRLQHTFKQEMTGVGASLEKRWKFC 573

Query: 636 AFEGIKTT 643
            FEG+K T
Sbjct: 574 GFEGLKLT 581


>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
           protein 6 [Homo sapiens]
          Length = 724

 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 66/299 (22%), Positives = 132/299 (44%), Gaps = 26/299 (8%)

Query: 222 RDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSE 281
           R +   WE +++MR +EE    K E+ R +      +M   E +   L EK+ +  K  E
Sbjct: 400 RQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEE----MMWEKEEKIRELEEKMHEQEKIRE 455

Query: 282 AITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQE--MEEAKENFKNAL 339
                       E  R+   +     +      +    E+   EQE  + E +E      
Sbjct: 456 Q-----------EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQE 504

Query: 340 TGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEE 399
             I  Q E+I        +++ W    K  R+  +IWR+  +E  + Q E+   IR++EE
Sbjct: 505 EKIHEQ-EKIREEEKRQEQEEMWRQEEKI-REQEEIWRQ--KEKIHEQEEK---IRKQEE 557

Query: 400 MEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFR 459
                +E      +K+R  E  +  Q   ++E+ + +R Q +  R + E+ ++++E++  
Sbjct: 558 KMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGE 617

Query: 460 TEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQ 518
            EE +   +Q + +Q+  + M++Q   I+E+    + + E+ +E++   Q   + + EQ
Sbjct: 618 QEEKMC--EQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQ 674



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 68/321 (21%), Positives = 132/321 (41%), Gaps = 40/321 (12%)

Query: 222 RDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSE-----HEAALLAEKLKDD 276
           R +   WE +++MR +EE    K  E+++R       MH  E      E     EK+++ 
Sbjct: 414 RQEEMMWEKEEKMRRQEEMMWEK--EEKIRELEEK--MHEQEKIREQEEKRQEEEKIREQ 469

Query: 277 SKFSEAITVLLSWIER----GEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAK 332
            K  E    +    E+     E  R    + +   +  +   +    EK   ++EM   +
Sbjct: 470 EKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQE 529

Query: 333 ENFKNALTGILTQFEQIVAVFNASTRQ--KAW-------DHFSKAQRKNIDIWRKHSEEL 383
           E  +     I  Q E+I        +Q  K W       D   K + +   +WR+  E++
Sbjct: 530 EKIREQ-EEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQE-EKI 587

Query: 384 RNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAY 443
           R    EQ   IR +EE     +E      +KM   E  +  Q   ++E+ + +R Q +  
Sbjct: 588 R----EQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKI 643

Query: 444 RNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSEL----- 498
           R + + +++++E++   EE + + ++  + Q+     Q++ +  QEE   ++ E      
Sbjct: 644 REQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQE 703

Query: 499 -------EQAKEEQSHTQALL 512
                  E+ +E Q H +A +
Sbjct: 704 VRLRQQEEKMQEHQEHLEAAI 724



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 89/441 (20%), Positives = 177/441 (40%), Gaps = 63/441 (14%)

Query: 163 EQCGDITAIRKSKKNFCHIRFAEEFMVDK-AIYLSGYRMRLGSSTDKKDSGRLHVDFAQA 221
           EQ     A +K K +    R+ EE   ++ A+ L  YR  +     K+ + +L     Q 
Sbjct: 239 EQALSAVATQKKKAD----RYIEELTKERDALSLELYRNTITDEELKEKNAKL-----QE 289

Query: 222 RDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSE 281
           +    E E K  ++   +  +RKLE  +L  P         + EA  L ++L+  S    
Sbjct: 290 KLQLVESE-KSEIQLNVKELKRKLERAKLLLPQQQL-----QAEADHLGKELQSVS---- 339

Query: 282 AITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTG 341
               L + +E  E+  R   Q    +      ++    +    E+++ E +E  +     
Sbjct: 340 --AKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEK 397

Query: 342 ILTQFEQIVAVFNASTRQKA--WDHFSKAQRKNIDIWRKHSE--ELRNAQSEQL----MG 393
           +  Q E +        RQ+   W+   K +R+   +W K  +  EL     EQ       
Sbjct: 398 MRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQE 457

Query: 394 IRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRW--------------- 438
            +R+EE ++ + E       KM   E  +  Q   ++E+ + + W               
Sbjct: 458 EKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKM-WRQEEKIHEQEKIREE 516

Query: 439 -----QLDAYRNEVELLKQE-----KEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQ 488
                Q + +R E ++ +QE     KE++   EE + K ++  + Q+     Q++ +  Q
Sbjct: 517 EKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQ 576

Query: 489 EELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVN 548
           EE   ++ E  + +EE+   Q   + ++EQ + T+E  E  G   E   E          
Sbjct: 577 EEKVWRQEEKIREQEEKIREQE--EKIREQEEMTQEQEEKMGEQEEKMCEQEEKM----- 629

Query: 549 QDRENNIEKRSQGLKSEKEAL 569
           Q++E  + ++ + ++ +++ +
Sbjct: 630 QEQEEKMRRQEEKIREQEKKI 650



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 46/285 (16%), Positives = 128/285 (44%), Gaps = 21/285 (7%)

Query: 259 MHYSEH-------EAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSANQFYSMVQSAN 311
           ++YS+H       EA  L  +L D  KF+  +   LS +      ++ A+++   +    
Sbjct: 207 LYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVA---TQKKKADRYIEELTKER 263

Query: 312 SHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRK 371
             +   +      ++E++E     +  L   L + E+     N    ++      K +R 
Sbjct: 264 DALSLELYRNTITDEELKEKNAKLQEKLQ--LVESEKSEIQLNVKELKR------KLERA 315

Query: 372 NIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKE 431
            + + ++  +   +   ++L  +  + + ++ ++E  +   ++    E  +  Q   ++E
Sbjct: 316 KLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQ---EEKMWRQEEKIQE 372

Query: 432 ENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEEL 491
             + ++ Q +  R + E +++++E++ R EE + + ++    Q+ M   +++ +  QEE+
Sbjct: 373 WEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEM 432

Query: 492 NNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDS 536
             +K E  +  EE+ H Q  ++  +E+ +  +++ E      +++
Sbjct: 433 MWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEA 477



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 62/317 (19%), Positives = 128/317 (40%), Gaps = 42/317 (13%)

Query: 227 EWECK---QRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAI 283
           EWE K   Q  + RE+  + + +E+++R       M + + E     E++  + +     
Sbjct: 372 EWEEKIQEQEEKIREQEEKIREQEEKMRRQEE---MMWEKEEKMRRQEEMMWEKEEKMRR 428

Query: 284 TVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGIL 343
              + W E+ E  R    + +   +      +R   EK   +++ +E +         I 
Sbjct: 429 QEEMMW-EKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIR 487

Query: 344 TQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMS 403
            Q E+I         +K W      Q + I    K  EE +  + E++    R+EE ++ 
Sbjct: 488 EQEEKI-----REQEEKMW-----RQEEKIHEQEKIREEEKRQEQEEMW---RQEE-KIR 533

Query: 404 DDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQE---------- 453
           + E      +K+   E  +       K+E    R +   +  E ++ +QE          
Sbjct: 534 EQEEIWRQKEKIHEQEEKIR------KQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKI 587

Query: 454 ---KEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQA 510
              +E++   EE + + +++   Q+   G Q++ +  QEE   ++ E  + +EE+   Q 
Sbjct: 588 REQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQE 647

Query: 511 LLKVLQEQLKGTKELVE 527
             K ++EQ +  +E  E
Sbjct: 648 --KKIREQEEKIREQEE 662


>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 668

 Score = 63.9 bits (154), Expect = 4e-10
 Identities = 56/300 (18%), Positives = 137/300 (45%), Gaps = 25/300 (8%)

Query: 222 RDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSE 281
           R +   WE +++MR +EE    K E+ R        +M   E +   L EK+ +  K  E
Sbjct: 339 RQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEE----MMWEKEEKIRELEEKMHEQEKIRE 394

Query: 282 AITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTG 341
                       E  R+   +     +      +    E+   EQE E+ +E  K     
Sbjct: 395 Q-----------EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQE-EKIREQEKKMWRQ 442

Query: 342 I--LTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEE 399
              + + E+I        +++ W    K  R+  +IWR+  +E  + Q +    IR++EE
Sbjct: 443 EEKIHEQEKIREEEKRQEQEEMWRQEEKI-REQEEIWRQ--KEKMHEQEK----IRKQEE 495

Query: 400 MEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFR 459
                +E      +K+R  E  +  Q   ++E+ + +R Q +  R + E++++++E++  
Sbjct: 496 KVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGE 555

Query: 460 TEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQL 519
            EE + + ++++  ++ ++  ++++   +E++  ++ ++ + +E+    + +++  +E++
Sbjct: 556 QEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKM 615



 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 60/307 (19%), Positives = 134/307 (43%), Gaps = 33/307 (10%)

Query: 228 WECKQRMRAREER----------HRRKLEEDRLRPPSP----PAIMHYSEHEAALLAEKL 273
           WE ++++R  EE+            ++ EE+++R         A M   E +     EK+
Sbjct: 373 WEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI 432

Query: 274 KDDSK--FSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQE-MEE 330
           ++  K  + +   +      R E  R+   + +   +           ++  HEQE + +
Sbjct: 433 REQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRK 492

Query: 331 AKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQS-- 388
            +E        +  Q E+I         +K W    K + +   I R+  E++R  +   
Sbjct: 493 QEEKVWRQEEKMHDQEEKI-----REQEEKMWRQEEKIREQEEKI-REQEEKIREQEEMM 546

Query: 389 ---EQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRN 445
              E+ MG   E+E +M + E      +K+R  E  +  Q   ++E+ + +  Q +  R 
Sbjct: 547 QEQEEKMG---EQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIRE 603

Query: 446 EVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQ 505
           + E++++++E+++  EE +   +Q + +Q+  + M++Q   + E+    + + E+ +E Q
Sbjct: 604 QEEMMQEQEEKMWEQEEKMC--EQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQ 661

Query: 506 SHTQALL 512
            H +A +
Sbjct: 662 EHLEAAI 668



 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 63/324 (19%), Positives = 140/324 (43%), Gaps = 29/324 (8%)

Query: 222 RDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSE-----HEAALLAEKLKDD 276
           R +   WE +++MR  EE    K  E+++R       MH  E      E     EK+++ 
Sbjct: 353 RQEEMMWEKEEKMRRLEEMMWEK--EEKIRELEEK--MHEQEKIREQEEKRQEEEKIREQ 408

Query: 277 SKFSEAITVLLSWIER----GEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAK 332
            K  E    +    E+     E  R    + +   +  +   +    EK   ++EM   +
Sbjct: 409 EKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQE 468

Query: 333 ENFKNALTGILTQFEQIVAVFNASTRQ-KAW-------DHFSKAQRKNIDIWRKHSEELR 384
           E  +     I  Q E++        ++ K W       D   K + +   +WR+  EE  
Sbjct: 469 EKIREQ-EEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQ--EEKI 525

Query: 385 NAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYR 444
             Q E++    RE+E ++ + E      ++   ++     +   ++ + + +R Q +  R
Sbjct: 526 REQEEKI----REQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIR 581

Query: 445 NEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEE 504
            + E +++++E+++  EE + + +++   Q+     Q++ +  QEE   ++ E  + +EE
Sbjct: 582 EQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEE 641

Query: 505 QSHTQAL-LKVLQEQLKGTKELVE 527
           +   Q + L+  +E+++  +E +E
Sbjct: 642 KMWEQEVRLRQQEEKMQEHQEHLE 665



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 57/315 (18%), Positives = 131/315 (41%), Gaps = 36/315 (11%)

Query: 227 EWECK---QRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAI 283
           EWE K   Q  + RE+  + + +E+++R       M + + E     E++  + +     
Sbjct: 311 EWEEKIQEQEEKIREQEEKIREQEEKMRRQEE---MMWEKEEKMRRQEEMMWEKEEKMRR 367

Query: 284 TVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGIL 343
              + W E+ E  R    + +   +      +R   EK   +++ +E +         I 
Sbjct: 368 LEEMMW-EKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIR 426

Query: 344 TQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMS 403
            Q E+I         +K W      Q + I    K  EE +  + E++    R+EE ++ 
Sbjct: 427 EQEEKI-----REQEKKMW-----RQEEKIHEQEKIREEEKRQEQEEMW---RQEE-KIR 472

Query: 404 DDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEEN 463
           + E      +KM   E         ++++ + +  Q +   ++ E +++++E+++R EE 
Sbjct: 473 EQEEIWRQKEKMHEQEK--------IRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEK 524

Query: 464 LTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTK 523
           + +       Q+     Q++ +  QEE+  ++ E    +EE+   Q  ++  +E+++  +
Sbjct: 525 IRE-------QEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQE 577

Query: 524 ELVETNGHSHEDSNE 538
           E +        +  E
Sbjct: 578 EKIREQKEKIREQEE 592



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 45/285 (15%), Positives = 127/285 (44%), Gaps = 21/285 (7%)

Query: 259 MHYSEH-------EAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSANQFYSMVQSAN 311
           ++YS+H       EA  L  +L D  KF+  +   LS +      ++ A+++   +    
Sbjct: 146 LYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVA---TQKKKADRYIEELTKER 202

Query: 312 SHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRK 371
             +   +      ++E++E     +  L   L + E+     N    ++      K +R 
Sbjct: 203 DALSLELYRNTITDEELKEKNAKLQEKLQ--LVESEKSEIQLNVKELKR------KLERA 254

Query: 372 NIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKE 431
            + + ++  +   +   ++L  +  + + ++ ++E  +   ++    E  +  Q   ++E
Sbjct: 255 KLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQ---EEKMWRQEEKIQE 311

Query: 432 ENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEEL 491
             + ++ Q +  R + E +++++E++ R EE + + ++    Q+ M   +++ +   EE+
Sbjct: 312 WEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEM 371

Query: 492 NNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDS 536
             +K E  +  EE+ H Q  ++  +E+ +  +++ E      +++
Sbjct: 372 MWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEA 416


>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 750

 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 60/310 (19%), Positives = 130/310 (41%), Gaps = 17/310 (5%)

Query: 220 QARDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKF 279
           Q  +   E E +Q   A+  R   K+ E   +       M + + E     EK++++ K 
Sbjct: 414 QEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKM-WRQEEKIHEQEKIREEEKR 472

Query: 280 SEAITVLLSWIERGEVN--------RRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEA 331
            E   +   W +  +++        +   ++    ++     V R   +    E+++ E 
Sbjct: 473 QEQEEM---WRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQ 529

Query: 332 KENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSE-- 389
           +E        I  Q E          ++K W+   K Q +   +WR+  E++R  + +  
Sbjct: 530 EEKMWRQEEKIREQEEMWREEEKMHEQEKIWEE-EKRQEQEDKMWRQE-EKIREQEEKVW 587

Query: 390 -QLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVE 448
            Q   IR +EE     +E      +K+R  E  +  Q   ++E+ + +R Q +  + + E
Sbjct: 588 RQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEE 647

Query: 449 LLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHT 508
            + +++E++   EE + + ++  + Q+     Q++ +  QEE   ++ E+ Q +EE+   
Sbjct: 648 KMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWE 707

Query: 509 QALLKVLQEQ 518
           Q      QE+
Sbjct: 708 QEEKMCEQEE 717



 Score = 53.5 bits (127), Expect = 6e-07
 Identities = 75/384 (19%), Positives = 167/384 (43%), Gaps = 38/384 (9%)

Query: 163 EQCGDITAIRKSKKNFCHIRFAEEFMVDK-AIYLSGYRMRLGSSTDKKDSGRLHVDFAQA 221
           EQ     A +K K +    R+ EE   ++ A+ L  YR  +     K+ + +L     Q 
Sbjct: 178 EQALSAVATQKKKAD----RYIEELTKERDALSLELYRNTITDEELKEKNAKL-----QE 228

Query: 222 RDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSE 281
           +    E E K  ++   +  +RKLE  +L  P         + EA  L ++L+  S    
Sbjct: 229 KLQLVESE-KSEIQLNVKELKRKLERAKLLLPQQQL-----QAEADHLGKELQSVS---- 278

Query: 282 AITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTG 341
               L + +E  E+  R   Q    +      ++    +    E+++ E +E  +     
Sbjct: 279 --AKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEK 336

Query: 342 ILTQFEQIVAVFNASTRQKA--WDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIR---- 395
           +  Q E +        RQ+   W+   K +R+   +W K  E++R  + E++M  +    
Sbjct: 337 MRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKE-EKMR--RQEEMMWEKEEKI 393

Query: 396 REEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRW-QLDAYRNEVELLKQEK 454
           RE E +M + E      +K + +E     +    ++E ++  W Q +  R + E +++++
Sbjct: 394 RELEEKMHEQEKIREQEEKRQEEEKIREQEK---RQEQEAKMWRQEEKIREQEEKIREQE 450

Query: 455 EQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKV 514
           ++++R EE + + ++++   +  +  +Q+ +  QEE  +++ E+ + KE+    +  ++ 
Sbjct: 451 KKMWRQEEKIHEQEKIR---EEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRK 507

Query: 515 LQEQLKGTKELVETNGHSHEDSNE 538
            +E++   +E +        +  E
Sbjct: 508 QEEKVWRQEEKIREQEEKIREQEE 531



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 49/290 (16%), Positives = 127/290 (43%), Gaps = 17/290 (5%)

Query: 259 MHYSEH-------EAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSANQFYSMVQSAN 311
           ++YS+H       EA  L  +L D  KF+  +   LS +      ++ A+++   +    
Sbjct: 146 LYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVA---TQKKKADRYIEELTKER 202

Query: 312 SHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKA-QR 370
             +   +      ++E++E     +  L   L + E+     N    ++  +       +
Sbjct: 203 DALSLELYRNTITDEELKEKNAKLQEKLQ--LVESEKSEIQLNVKELKRKLERAKLLLPQ 260

Query: 371 KNIDIWRKH-SEELRNAQSEQLMGIRREE---EMEMSDDENCDSPTKKMRVDESALAAQA 426
           + +     H  +EL++  ++    +   E    +    +E      +K++  E  +  Q 
Sbjct: 261 QQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQE 320

Query: 427 YALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLT 486
             ++E+ + +R Q +  R + E++ +++E++ R EE + + ++    Q+ M   +++ + 
Sbjct: 321 EKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMR 380

Query: 487 IQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDS 536
            QEE+  +K E  +  EE+ H Q  ++  +E+ +  +++ E      +++
Sbjct: 381 RQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEA 430



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 59/295 (20%), Positives = 119/295 (40%), Gaps = 38/295 (12%)

Query: 228 WECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKL-KDDSKFSEAITVL 286
           W  ++++  +EE  R+K +            MH  E +     EK+ + + K  E     
Sbjct: 479 WRQEEKIHEQEEIWRQKEK------------MHEQEEKIRKQEEKVWRQEEKIRE----- 521

Query: 287 LSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQF 346
                + E  R    + +   +           E+  HEQE    +E  +     +  Q 
Sbjct: 522 -----QEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQE 576

Query: 347 EQIVAVFNASTRQ--KAWDHFSKAQRKNIDIWRKHSEELRNAQS----------EQLMGI 394
           E+I        RQ  K  +   K Q +   +W K  E++R  +           EQ   I
Sbjct: 577 EKIREQEEKVWRQEEKIREQEEKRQEQEEKMW-KQEEKIREQEEKIQEQEEKIREQEEKI 635

Query: 395 RREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEK 454
           R +EEM    +E      +KM   E  +  Q   +  + + +R Q    R + E +++++
Sbjct: 636 REQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQE 695

Query: 455 EQLFRTEENL-TKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEE-QSH 507
           E +   EE +  +++++   ++ MQ  ++++   +E++  ++  L Q +E+ Q H
Sbjct: 696 EMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEH 750


>gi|34577114 cytomatrix protein p110 [Homo sapiens]
          Length = 957

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 75/370 (20%), Positives = 159/370 (42%), Gaps = 45/370 (12%)

Query: 231 KQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWI 290
           KQ + AR+E  ++ LE   L+    P+     ++E      ++ +       + V+L   
Sbjct: 295 KQTLNARDESIKKLLE--MLQSKGLPSKSLEDDNERT---RRMAEAESQVSHLEVILDQK 349

Query: 291 ERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIV 350
           E+  ++ R      S +Q   +  + L       + ++   + N ++    I  Q  +  
Sbjct: 350 EKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEI--QMLKAN 407

Query: 351 AVFNASTRQKAWDHFSKAQRKNIDIWRKHS-----------EELRNAQSEQLMGIRREEE 399
            V N   R++        + K I++++ HS           +EL   +SE L+ ++ + E
Sbjct: 408 GVLNTEDREE--------EIKQIEVYKSHSKFMKTKIDQLKQELSKKESE-LLALQTKLE 458

Query: 400 MEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFR 459
              + + +C    + ++   +A   +A  L+ E D+LR +L+    E  L K+ K+    
Sbjct: 459 TLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLE--EKESFLNKKTKQLQDL 516

Query: 460 TEENLT--------------KDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQ 505
           TEE  T              K++++  LQ+ ++ +Q+QL    ++L N K  ++  + + 
Sbjct: 517 TEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDS 576

Query: 506 SHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKRS--QGLK 563
           S+T   L  L+E L   + ++E      E  +   +  +    ++ ++  EK +  Q   
Sbjct: 577 SNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAEL 636

Query: 564 SEKEALLIGI 573
           +EKE+ LI +
Sbjct: 637 TEKESSLIDL 646



 Score = 37.4 bits (85), Expect = 0.043
 Identities = 88/421 (20%), Positives = 158/421 (37%), Gaps = 49/421 (11%)

Query: 229 ECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEA-ITVLL 287
           E K    A  ER+ R LE++     +   +      E     E  K  SKF +  I  L 
Sbjct: 381 EMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLK 440

Query: 288 SWIERGEVNRRSANQFYSMVQSANS----HVRRLMNEKATHEQEME-------------E 330
             + + E    +       + + NS    H+  L       EQ                E
Sbjct: 441 QELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLE 500

Query: 331 AKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNA---Q 387
            KE+F N  T  L    +         R    D     +RK I++ +K  E L+     +
Sbjct: 501 EKESFLNKKTKQLQDLTEEKGTLAGEIRDMK-DMLEVKERK-INVLQKKIENLQEQLRDK 558

Query: 388 SEQLMGIRREEEMEMSDDENCDSPTKKMRV---DESALAAQAYALKEENDSLRWQ-LDAY 443
            +QL  ++   +   +D  N D+    +     ++  +  +    +E +D  R + ++++
Sbjct: 559 DKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIESF 618

Query: 444 RNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKE 503
           R E + LK++   L    E   K+  L  L++    +    L    +L + +  +EQ KE
Sbjct: 619 RKENKDLKEKVNAL--QAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKE 676

Query: 504 EQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLT-----------VALVNQDRE 552
           E S        L+ QLK    + + +  + E +++I  L             A    DR 
Sbjct: 677 ECSK-------LEAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRL 729

Query: 553 NNIEKRSQGLKSEKEALLIGIIS-TFLHVHPFGANIEYLWSYMQQLDSKISANEIEMLLM 611
             I K  +  K++K+  +  + S T  H+      +  L  + QQL+ K +A  +E +  
Sbjct: 730 LEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANL-KHNQQLEKKKNAQLLEEVRR 788

Query: 612 R 612
           R
Sbjct: 789 R 789



 Score = 34.3 bits (77), Expect = 0.36
 Identities = 42/168 (25%), Positives = 76/168 (45%), Gaps = 32/168 (19%)

Query: 422 LAAQAYALKEENDSLRWQLD-------AYRNEVELL---KQEKEQLFRTEE----NLTKD 467
           L AQ   L+ END LR +LD       +  N ++     + +KE++ R EE    ++ K+
Sbjct: 150 LQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLKE 209

Query: 468 Q------QLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKG 521
           Q      + Q LQ T+Q +Q +L T Q +LN+    L+Q    +      +++ +E  + 
Sbjct: 210 QMRVSHEENQHLQLTIQALQDELRT-QRDLNHL---LQQESGNRGAEHFTIELTEENFR- 264

Query: 522 TKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEAL 569
                         + E+ +L   L  ++ E  IE + Q L +  E++
Sbjct: 265 -----RLQAEHDRQAKELFLLRKTL--EEMELRIETQKQTLNARDESI 305



 Score = 32.7 bits (73), Expect = 1.1
 Identities = 50/275 (18%), Positives = 115/275 (41%), Gaps = 36/275 (13%)

Query: 257 AIMHYSEHEAALLAEKLKDDSKFS----------EAITVLLSWIERG---EVNRRSANQF 303
           +++   EH ++L +  LK DSK            E  + L + +++    E + R   +F
Sbjct: 642 SLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEF 701

Query: 304 YSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWD 363
              ++  +       +E    + E++   E  K        + ++I  + + + R     
Sbjct: 702 ADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLR----- 756

Query: 364 HFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALA 423
           H     +K  ++  KH+++L   ++ QL+   R  E  M+D+      ++ ++++E    
Sbjct: 757 HMKDQNKKVANL--KHNQQLEKKKNAQLLEEVRRREDSMADN------SQHLQIEE---- 804

Query: 424 AQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQ 483
                L    +  R +LDA +  +   +Q   +      NL  +++ Q L++ ++  Q+ 
Sbjct: 805 -----LMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQ-LEEILEMKQEA 858

Query: 484 LLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQ 518
           LL    E +   + LE +  ++  TQ  +  L+ +
Sbjct: 859 LLAAISEKDANIALLELSASKKKKTQEEVMALKRE 893


>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
           sapiens]
          Length = 436

 Score = 60.1 bits (144), Expect = 6e-09
 Identities = 54/260 (20%), Positives = 108/260 (41%), Gaps = 10/260 (3%)

Query: 307 VQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFS 366
           V+     VR    +    E +M E +E        +  Q EQ+        +Q+      
Sbjct: 180 VREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQ 239

Query: 367 KAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQA 426
           + Q +  +   +  EE    Q EQ+    RE+E +M + E      K+    E     Q 
Sbjct: 240 EEQVQKQEEQVQKQEEQMRKQEEQM----REQEEQMREQEEQMLKQKEQTEQEEQTGEQE 295

Query: 427 YALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLT 486
             ++E+ + +R Q +  R + E +++++EQ+ + EE + + ++  + Q+     Q++ + 
Sbjct: 296 EQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMG 355

Query: 487 IQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVAL 546
            QEE   K+ E  + +EEQ   Q      +EQ++  +E +        +  E        
Sbjct: 356 EQEEQMQKQEEQVRKQEEQMRKQ------EEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQ 409

Query: 547 VNQDRENNIEKRSQGLKSEK 566
           + +  E   E++ Q  K E+
Sbjct: 410 MREQEEQMGEQKEQMRKQEE 429



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 44/203 (21%), Positives = 89/203 (43%), Gaps = 11/203 (5%)

Query: 307 VQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFS 366
           VQ     V++   +    E++M E +E  +     +L Q EQ        T Q+      
Sbjct: 243 VQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQ--------TEQEEQTGEQ 294

Query: 367 KAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQA 426
           + Q +  +   +  EE    Q EQ+   R +EE     +E      ++M   +  +  Q 
Sbjct: 295 EEQMREQEEQMREQEEQMREQEEQM---REQEEQMGKQEEQMWEQKEQMWEQKEQMWKQE 351

Query: 427 YALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLT 486
             + E+ + ++ Q +  R + E +++++EQ+ + EE + K ++    Q+   G Q++ + 
Sbjct: 352 EQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMR 411

Query: 487 IQEELNNKKSELEQAKEEQSHTQ 509
            QEE   ++ E  + +EE    Q
Sbjct: 412 EQEEQMGEQKEQMRKQEEHMGEQ 434



 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 35/184 (19%), Positives = 83/184 (45%), Gaps = 6/184 (3%)

Query: 384 RNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAY 443
           +  Q  +  G  RE+E +M + E       +M   E  +  Q   ++++ + +  Q +  
Sbjct: 176 QEGQVREQEGQVREQEGQMGEQEG------QMGEQEEQMGEQEEQMQKQEEQMGEQEEQM 229

Query: 444 RNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKE 503
           R + E + +++EQ+ + EE + K ++    Q+     Q++ +  QEE   K+ E  + +E
Sbjct: 230 RKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEE 289

Query: 504 EQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLK 563
           +    +  ++  +EQ++  +E +        +  E        + + +E   E++ Q  K
Sbjct: 290 QTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWK 349

Query: 564 SEKE 567
            E++
Sbjct: 350 QEEQ 353



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 40/215 (18%), Positives = 94/215 (43%), Gaps = 23/215 (10%)

Query: 384 RNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAY 443
           +  Q  +  G  RE+E ++ + E       ++R  E  +  Q   ++E+   +  Q    
Sbjct: 148 QEGQVREQEGQVREQEGQVREQEG------QVREQEGQVREQEGQVREQEGQMGEQEGQM 201

Query: 444 RNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKE 503
             + E + +++EQ+ + EE + + ++    Q+   G Q++ +  QEE   K+ E  + +E
Sbjct: 202 GEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQE 261

Query: 504 EQSHTQ-ALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGL 562
           EQ   Q   ++  +EQ+   KE  E    + E   ++      +  +++E  + ++ + +
Sbjct: 262 EQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQM--REQEEQMREQEEQM 319

Query: 563 KSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQL 597
           + ++E +              G   E +W   +Q+
Sbjct: 320 REQEEQM--------------GKQEEQMWEQKEQM 340



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 40/186 (21%), Positives = 84/186 (45%), Gaps = 9/186 (4%)

Query: 384 RNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAY 443
           +  Q  +  G  RE+E ++ + E       ++R  E  +  Q   ++E+   +R Q    
Sbjct: 106 QEGQVREQEGQVREQEGQVREQEG------QVREQEGQVREQEGQVREQEGQVREQEGQV 159

Query: 444 RNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQ-GMQQQLLTIQEELNNKKSELEQAK 502
           R +   +++++ Q+ R +E   ++Q+ Q  +Q  Q G Q+  +  QEE   ++ E  Q +
Sbjct: 160 REQEGQVREQEGQV-REQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQ 218

Query: 503 EEQ-SHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQG 561
           EEQ    +  ++  +EQ+   +E V+      +   E        + +  E   E+  Q 
Sbjct: 219 EEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQM 278

Query: 562 LKSEKE 567
           LK +++
Sbjct: 279 LKQKEQ 284


>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 828

 Score = 59.7 bits (143), Expect = 8e-09
 Identities = 55/277 (19%), Positives = 122/277 (44%), Gaps = 28/277 (10%)

Query: 228 WECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLL 287
           W+ ++RM  ++ER R K  E+R+R       M   E       EK++++ K  E      
Sbjct: 503 WDQEERMWEQDERLREK--EERMREQKK---MWQQE-------EKMREEKKTQEQEKKTW 550

Query: 288 SWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFE 347
              E+     R   +   M +        +M E+   E++M+E +E  +     +  Q E
Sbjct: 551 DQEEKMREEERMREREKKMREE-----EEMMREQ---EEKMQEQEEKMREQEEKMWEQEE 602

Query: 348 QIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDEN 407
           ++         +K W+   K   +  +   +  EE+   Q E++   + +EE     +E 
Sbjct: 603 KM-----QEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKM---QEQEEKMWEQEEK 654

Query: 408 CDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKD 467
                +KMR  E  +  Q   ++E+ + ++ Q +  R + E ++ ++E+++  EE +   
Sbjct: 655 MREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQ 714

Query: 468 QQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEE 504
           ++  + Q+ M+  ++++   +E++  +  E E+   E
Sbjct: 715 EEKMWGQEEMREKEERIRDQKEKMQERLPEHEERCSE 751



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 58/320 (18%), Positives = 138/320 (43%), Gaps = 20/320 (6%)

Query: 213 RLHVDFAQARDDFYEWECKQRM----RAREERHRRKLEEDRLRPPSPPAIMHYSEHEAAL 268
           RL     + R+    WE +++M    R RE   + + EE+ +R       M   E     
Sbjct: 367 RLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEK--MQKQEENMWE 424

Query: 269 LAEKLKDDSKFSEAITVLLSWIERGEVNRRSANQFYSMVQSAN--SHVRRLMNEKATHEQ 326
             EK     +  E    L    +  E   +   Q   +          +++  ++   EQ
Sbjct: 425 QEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQ 484

Query: 327 E--MEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELR 384
           E  M E +E  ++    +  Q E++   +    R +  +   + Q+K      K  EE +
Sbjct: 485 EDQMWEQEEKMRDQEQKMWDQEERM---WEQDERLREKEERMREQKKMWQQEEKMREEKK 541

Query: 385 NAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYR 444
             + E+      ++E +M ++E      KKMR +E  +  Q   ++E+ + +R Q +   
Sbjct: 542 TQEQEKKTW---DQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMW 598

Query: 445 NEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEE 504
            + E +++++E+++  EE + + ++    +  MQ  ++ +   +E++  ++ ++ + +E+
Sbjct: 599 EQEEKMQEQEEKMWEQEEKMWEQEE----EDKMQEQEEMMWEQEEKMQEQEEKMWEQEEK 654

Query: 505 QSHTQALLKVLQEQLKGTKE 524
               +  ++  +E+++G +E
Sbjct: 655 MREQEEKMREQEEKMQGQEE 674



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 39/198 (19%), Positives = 95/198 (47%), Gaps = 9/198 (4%)

Query: 374 DIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEEN 433
           ++WR+  EELR    EQ   IR++EE     +E       KMR  E  +  Q   L+E+ 
Sbjct: 235 EMWRQE-EELR----EQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQE 289

Query: 434 DSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNN 493
             LR Q    R + +L +QE++   + E+   ++++++  ++ M   +++L   ++++  
Sbjct: 290 KELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMRE 349

Query: 494 KKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHED----SNEINVLTVALVNQ 549
           ++ ++   +E        L+  +E+++  +++ E      E+      E  +       +
Sbjct: 350 QEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMR 409

Query: 550 DRENNIEKRSQGLKSEKE 567
           ++E  ++K+ + +  ++E
Sbjct: 410 EQEEKMQKQEENMWEQEE 427



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 63/293 (21%), Positives = 130/293 (44%), Gaps = 30/293 (10%)

Query: 228 WECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLL 287
           WE +++MR +EE+  R  +E+RL            E +     +K++D     E +    
Sbjct: 320 WEQEEKMREQEEKMWR--QEERL---------WEQEKQMREQEQKMRDQ---EERMWEQD 365

Query: 288 SWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQE--MEEAKENFKNALTGILTQ 345
             +   E   R   + +   +      R    EK   E+E  M E +E  +     +  Q
Sbjct: 366 ERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQ 425

Query: 346 FEQIVAVFN-ASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMG----IRREEEM 400
            E+          ++K W+   K Q +   IW +  E++R+   E++ G    + R+E+M
Sbjct: 426 EEKEWQQQRLPEQKEKLWEQ-EKMQEQEEKIW-EQEEKIRD--QEEMWGQEKKMWRQEKM 481

Query: 401 EMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQE----KEQ 456
              +D+  +   +KMR  E  +  Q   + E+++ LR + +  R + ++ +QE    +E+
Sbjct: 482 REQEDQMWEQ-EEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEK 540

Query: 457 LFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQ 509
             + +E  T DQ+ +  ++     +++ +  +EE+  ++ E  Q +EE+   Q
Sbjct: 541 KTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQ 593



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 49/238 (20%), Positives = 102/238 (42%), Gaps = 22/238 (9%)

Query: 317 LMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIW 376
           L  E    E+E+ E ++  +     +  Q E++        + +  +   + Q K +   
Sbjct: 232 LQEEMWRQEEELREQEKKIRKQEEKMWRQEERLR---EQEGKMREQEEKMRRQEKRL--- 285

Query: 377 RKHSEELRNAQSE--QLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEEND 434
           R+  +ELR  + E  +   +R +EE     +E      +KMR  E  +  Q   L E+  
Sbjct: 286 REQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEK 345

Query: 435 SLR-------------WQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQ 481
            +R             W+ D    E E   +E+E+++  EE + ++++++  ++ M+  +
Sbjct: 346 QMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMR-EE 404

Query: 482 QQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEI 539
           ++ +  QEE   K+ E    +EE+   Q  L   +E+L   +++ E      E   +I
Sbjct: 405 EETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKI 462



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 32/177 (18%), Positives = 87/177 (49%), Gaps = 5/177 (2%)

Query: 397 EEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQ 456
           +EEM   ++E  +   KK+R  E  +  Q   L+E+   +R Q +  R + + L++++++
Sbjct: 233 QEEMWRQEEELREQE-KKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKE 291

Query: 457 LFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQ 516
           L   E+ L + ++L+  ++ MQ  ++++   +E++  ++ ++ + +E     +  ++  +
Sbjct: 292 LREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQE 351

Query: 517 EQLKGTKELV----ETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEAL 569
           ++++  +E +    E      E   E   +         E  I +R + ++ E+E +
Sbjct: 352 QKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETM 408



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 67/353 (18%), Positives = 147/353 (41%), Gaps = 35/353 (9%)

Query: 228 WECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKD-DSKFSEAITVL 286
           WE  +R+R +EER R   E++++          + + E     E++++ + K  E    +
Sbjct: 362 WEQDERLREKEERMR---EQEKM----------WEQEEKMQEEERIREREKKMREEEETM 408

Query: 287 LSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQF 346
               E+  + ++  N +    +           EK   +++M+E +E        I  Q 
Sbjct: 409 REQEEK--MQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQ- 465

Query: 347 EQIVAVFNASTRQKA--------WDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGI--RR 396
           E++        RQ+         W+   K + +   +W +  EE    Q E+L     R 
Sbjct: 466 EEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQ--EERMWEQDERLREKEERM 523

Query: 397 EEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQ 456
            E+ +M   E      KK +  E     Q   ++EE + +R +    R E E++++++E+
Sbjct: 524 REQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREE-ERMREREKKMREEEEMMREQEEK 582

Query: 457 LFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQ 516
           +   EE + + ++  + Q+     Q++ +  QEE   ++ E ++ +E++       + +Q
Sbjct: 583 MQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQ 642

Query: 517 EQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEAL 569
           EQ +   E  E      E   E          Q +E  + ++ + ++ ++E +
Sbjct: 643 EQEEKMWEQEEKMREQEEKMREQEEKM-----QGQEEKMREQEEKMQGQEEKM 690


>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
           member 6-like protein 6 [Homo sapiens]
          Length = 655

 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 53/259 (20%), Positives = 119/259 (45%), Gaps = 13/259 (5%)

Query: 307 VQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFS 366
           ++     +R    +    E+++ E  E  +     +  Q E+I        ++K W    
Sbjct: 355 IREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQ-EEKRQEKMWRQEK 413

Query: 367 KAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQA 426
           K + ++  I R+  EE+   + +    IR  EEM    +E      +KM+ +E  +  Q 
Sbjct: 414 KMREQDEKI-REQEEEMWRQEEK----IRELEEMMQDQEEKLREVEEKMQEEEEKMQEQE 468

Query: 427 YALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQ-QTMQGMQQQLL 485
             ++ + + ++ Q +    + +LLKQE E+++  EE + + ++  + Q + MQ  ++++ 
Sbjct: 469 EKIQRQEEKIQEQEEKTWRQEKLLKQE-EKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQ 527

Query: 486 TIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVA 545
             +E++  ++  L Q +E+    +  L+ L+E+L    +  E  G +  +S    + T+ 
Sbjct: 528 RQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLGGAGRESGSQRLPTLT 587

Query: 546 LVNQDRENNIEKRSQGLKS 564
            + Q     +E +SQ  +S
Sbjct: 588 PILQ-----VELKSQEAQS 601



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 50/273 (18%), Positives = 131/273 (47%), Gaps = 35/273 (12%)

Query: 314 VRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNI 373
           +R + +EK+  +  +++ K   + A   +L Q +  V         ++     +AQ +  
Sbjct: 227 LRLVESEKSEIQLNVKDLKRKLERAQL-LLPQQQLQVEADRLGKELQSVSAKLQAQVEEN 285

Query: 374 DIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTK------KMRVDESALAAQAY 427
           ++W      L N Q E+ M  R+EE+++  +++ C+   K      KM   E  +  Q  
Sbjct: 286 ELWN-----LLNQQQEEKMW-RQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEE 339

Query: 428 ALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENL-TKDQQLQFLQQTM--------- 477
            ++E+ D +  Q +  R + E +++++E+++R EE +  +D+++Q  ++ M         
Sbjct: 340 KIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIRE 399

Query: 478 --QGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKE-LVETNGHSHE 534
             +  Q+++   ++++  +  ++ + +EE    +  ++ L+E ++  +E L E      E
Sbjct: 400 QEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQE 459

Query: 535 DSNEINVLTVALVNQDRENNIEKRSQGLKSEKE 567
           +  ++         Q++E  I+++ + ++ ++E
Sbjct: 460 EEEKM---------QEQEEKIQRQEEKIQEQEE 483



 Score = 34.7 bits (78), Expect = 0.28
 Identities = 54/262 (20%), Positives = 101/262 (38%), Gaps = 53/262 (20%)

Query: 228 WECKQRMRAREERHRRKL--EEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITV 285
           W  ++++R +EE+ + K+  +E ++R                   EK+++  +       
Sbjct: 391 WRQEEKIREQEEKRQEKMWRQEKKMREQD----------------EKIREQEE------- 427

Query: 286 LLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQ 345
              W +  ++      +   M+Q     +R +  +    E++M+E +E        I  Q
Sbjct: 428 -EMWRQEEKI-----RELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEK-------IQRQ 474

Query: 346 FEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDD 405
            E+I         +K W    K  ++   IW +  EE    Q E++     +EE     +
Sbjct: 475 EEKI-----QEQEEKTWRQ-EKLLKQEEKIWEQ--EEKMWRQEEKMW---EQEEKMQEQE 523

Query: 406 ENCDSPTKKMRVDESALAAQAYALKEEN---DSLRWQLDAYRNEVELL-KQEKEQLFRTE 461
           E      +KMR  E  L  Q   ++E+      L  +L     + ELL    +E   +  
Sbjct: 524 EKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLGGAGRESGSQRL 583

Query: 462 ENLTKDQQLQFLQQTMQGMQQQ 483
             LT   Q++   Q  Q +QQQ
Sbjct: 584 PTLTPILQVELKSQEAQSLQQQ 605


>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
           member 6-like protein 6 [Homo sapiens]
          Length = 655

 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 53/259 (20%), Positives = 119/259 (45%), Gaps = 13/259 (5%)

Query: 307 VQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFS 366
           ++     +R    +    E+++ E  E  +     +  Q E+I        ++K W    
Sbjct: 355 IREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQ-EEKRQEKMWRQEK 413

Query: 367 KAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQA 426
           K + ++  I R+  EE+   + +    IR  EEM    +E      +KM+ +E  +  Q 
Sbjct: 414 KMREQDEKI-REQEEEMWRQEEK----IRELEEMMQDQEEKLREVEEKMQEEEEKMQEQE 468

Query: 427 YALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQ-QTMQGMQQQLL 485
             ++ + + ++ Q +    + +LLKQE E+++  EE + + ++  + Q + MQ  ++++ 
Sbjct: 469 EKIQRQEEKIQEQEEKTWRQEKLLKQE-EKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQ 527

Query: 486 TIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVA 545
             +E++  ++  L Q +E+    +  L+ L+E+L    +  E  G +  +S    + T+ 
Sbjct: 528 RQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLGGAGRESGSQRLPTLT 587

Query: 546 LVNQDRENNIEKRSQGLKS 564
            + Q     +E +SQ  +S
Sbjct: 588 PILQ-----VELKSQEAQS 601



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 50/273 (18%), Positives = 131/273 (47%), Gaps = 35/273 (12%)

Query: 314 VRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNI 373
           +R + +EK+  +  +++ K   + A   +L Q +  V         ++     +AQ +  
Sbjct: 227 LRLVESEKSEIQLNVKDLKRKLERAQL-LLPQQQLQVEADRLGKELQSVSAKLQAQVEEN 285

Query: 374 DIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTK------KMRVDESALAAQAY 427
           ++W      L N Q E+ M  R+EE+++  +++ C+   K      KM   E  +  Q  
Sbjct: 286 ELWN-----LLNQQQEEKMW-RQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEE 339

Query: 428 ALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENL-TKDQQLQFLQQTM--------- 477
            ++E+ D +  Q +  R + E +++++E+++R EE +  +D+++Q  ++ M         
Sbjct: 340 KIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIRE 399

Query: 478 --QGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKE-LVETNGHSHE 534
             +  Q+++   ++++  +  ++ + +EE    +  ++ L+E ++  +E L E      E
Sbjct: 400 QEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQE 459

Query: 535 DSNEINVLTVALVNQDRENNIEKRSQGLKSEKE 567
           +  ++         Q++E  I+++ + ++ ++E
Sbjct: 460 EEEKM---------QEQEEKIQRQEEKIQEQEE 483



 Score = 34.7 bits (78), Expect = 0.28
 Identities = 54/262 (20%), Positives = 101/262 (38%), Gaps = 53/262 (20%)

Query: 228 WECKQRMRAREERHRRKL--EEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITV 285
           W  ++++R +EE+ + K+  +E ++R                   EK+++  +       
Sbjct: 391 WRQEEKIREQEEKRQEKMWRQEKKMREQD----------------EKIREQEE------- 427

Query: 286 LLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQ 345
              W +  ++      +   M+Q     +R +  +    E++M+E +E        I  Q
Sbjct: 428 -EMWRQEEKI-----RELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEK-------IQRQ 474

Query: 346 FEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDD 405
            E+I         +K W    K  ++   IW +  EE    Q E++     +EE     +
Sbjct: 475 EEKI-----QEQEEKTWRQ-EKLLKQEEKIWEQ--EEKMWRQEEKMW---EQEEKMQEQE 523

Query: 406 ENCDSPTKKMRVDESALAAQAYALKEEN---DSLRWQLDAYRNEVELL-KQEKEQLFRTE 461
           E      +KMR  E  L  Q   ++E+      L  +L     + ELL    +E   +  
Sbjct: 524 EKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLGGAGRESGSQRL 583

Query: 462 ENLTKDQQLQFLQQTMQGMQQQ 483
             LT   Q++   Q  Q +QQQ
Sbjct: 584 PTLTPILQVELKSQEAQSLQQQ 605


>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 899

 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 50/209 (23%), Positives = 92/209 (44%), Gaps = 28/209 (13%)

Query: 374 DIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEEN 433
           ++WR+  EELR    EQ   IR++EE     +E       KMR  E  +  Q   L+E+ 
Sbjct: 273 EMWRQE-EELR----EQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQE 327

Query: 434 DSLRWQLDAYRNEVELLKQE-------------KEQLFRTEENLTKDQQLQFLQQTMQGM 480
             LR Q    R + EL +QE             +E++   EE + + ++  + Q+     
Sbjct: 328 KELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMRE 387

Query: 481 QQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEIN 540
           Q+Q +  QEE   ++ E  + KEE+   Q  +    E+++  K++ E    + +   ++ 
Sbjct: 388 QEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKM- 446

Query: 541 VLTVALVNQDRENNIEKRSQGLKSEKEAL 569
                      E  I +R + ++ E+E +
Sbjct: 447 ---------QEEERIREREKKMREEEETM 466



 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 61/361 (16%), Positives = 157/361 (43%), Gaps = 29/361 (8%)

Query: 228 WECKQRMRAREERHRRKLEE-DRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVL 286
           WE  +R+R +EER R + +  +++        M   E +     EK++++ +  E    +
Sbjct: 400 WEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKM 459

Query: 287 LSWIE-----RGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTG 341
               E       ++ ++  N +    +           EK   +++M+E +E        
Sbjct: 460 REEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEK 519

Query: 342 ILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNA------QSEQLMGIR 395
           I  Q E           +K W    K + +   +W +  E++R+       Q E++    
Sbjct: 520 IRDQEEMW------GQEKKMWRQ-EKMREQEDQMWEQE-EKMRDQEQKMWDQEERMEKKT 571

Query: 396 REEEME-------MSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVE 448
           +E+E +       M ++E      KKMR +E  +  Q   ++E+ + ++ Q +    + E
Sbjct: 572 QEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEE 631

Query: 449 LLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHT 508
            +++++E+++  EE + + ++  + QQ +   +++L   + E   ++ ++++ +E+    
Sbjct: 632 KMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLW--EHEKMQEQEKMQEQEEKIWEQ 689

Query: 509 QALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEA 568
           + + K  QEQ K T +  +          E  +     + +++E  ++++ + ++ ++E 
Sbjct: 690 EKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEE 749

Query: 569 L 569
           +
Sbjct: 750 M 750



 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 63/385 (16%), Positives = 154/385 (40%), Gaps = 56/385 (14%)

Query: 228 WECKQRMRAREER----------HRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDS 277
           WE +++MR +EE+            +++ E   +       M   +       E++++  
Sbjct: 358 WEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQE 417

Query: 278 KFSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKN 337
           K  E +  +    +  E  +++ +Q   M +     +R    +    E+ M E +E  + 
Sbjct: 418 KMWEQVEKMREEKKMQEQEKKTRDQEEKMQE--EERIREREKKMREEEETMREQEEKMQK 475

Query: 338 ALTGILTQFEQIVAVFN-ASTRQKAWDHFSKAQRKNIDIWRK------------------ 378
               +  Q E+          ++K W+   K Q +   IW +                  
Sbjct: 476 QEENMWEQEEKEWQQQRLPEQKEKLWEQ-EKMQEQEEKIWEQEEKIRDQEEMWGQEKKMW 534

Query: 379 HSEELRNAQS---EQLMGIRREEEMEMSDDENCDSPT-----------KKMRVDESALAA 424
             E++R  +    EQ   +R +E+     +E  +  T           +KMR +E  +  
Sbjct: 535 RQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMR-EEERMRE 593

Query: 425 QAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQL 484
           +   ++EE + +R Q +  + + E +++++E+++  EE + + ++  + Q+     Q++ 
Sbjct: 594 REKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEK 653

Query: 485 LTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTV 544
           +  Q+ L  +K +L + ++ Q          QE+++  +E +       + + E    T 
Sbjct: 654 MWEQQRLPEQKEKLWEHEKMQE---------QEKMQEQEEKIWEQEKMEKKTQEQEKKTW 704

Query: 545 ALVNQDRENNIEKRSQGLKSEKEAL 569
                  E ++ +R + ++ E+E +
Sbjct: 705 DQEKMREEESMREREKKMREEEEMM 729



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 61/336 (18%), Positives = 141/336 (41%), Gaps = 49/336 (14%)

Query: 228 WECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLL 287
           WE +++MR +E++     +E+R+   +        + E     EK++++ +  E    + 
Sbjct: 547 WEQEEKMRDQEQKMWD--QEERMEKKTQEQEKKTWDQE-----EKMREEERMREREKKMR 599

Query: 288 SWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFE 347
              E  E+ R    +     +       ++  +    E++M+E +E        +  Q E
Sbjct: 600 ---EEEEMMREQEEKMQEQEEKMQEQEEKMWEQ----EEKMQEQEEKMWEQEEKMWEQEE 652

Query: 348 QIVAVFNA-STRQKAWDHFS-----KAQRKNIDIWRKHS---------------EELRNA 386
           ++         ++K W+H       K Q +   IW +                 E++R  
Sbjct: 653 KMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREE 712

Query: 387 QS--EQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYR 444
           +S  E+   +R EEEM    +E      +KM+  E  +  Q   + E+ + + W+     
Sbjct: 713 ESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKM-WEQQRLP 771

Query: 445 NEVELL-----KQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELE 499
            + E L      QE+E+++  EE + +DQ     ++ M+G ++++   +E++  ++ ++ 
Sbjct: 772 EQKEKLWEHEKMQEQEKIWEQEEKM-RDQ-----EEKMRGQEEKMRGQEEKMRGQEEKMW 825

Query: 500 QAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHED 535
             +E+    +  +   +E++ G +E +E      E+
Sbjct: 826 GQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEE 861



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 51/310 (16%), Positives = 136/310 (43%), Gaps = 28/310 (9%)

Query: 228 WECKQRMRAREE---RHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAIT 284
           WE ++++R +EE   + ++   ++++R       M   E +     +K+ D  +  E  T
Sbjct: 514 WEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQ--MWEQEEKMRDQEQKMWDQEERMEKKT 571

Query: 285 VLLSWIERGEVNRRSANQFYSMVQSANSHVR-RLMNEKAT----HEQEMEEAKENFKNAL 339
                    E  +++ +Q   M +      R + M E+       E++M+E +E  +   
Sbjct: 572 Q--------EQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQE 623

Query: 340 TGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEE 399
             +  Q E++         +K W+   K   +   +W +     +  +  +   ++ +E+
Sbjct: 624 EKMWEQEEKM-----QEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEK 678

Query: 400 MEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFR 459
           M+  +++  +    + +  E            E +S+R +    R E E++++++E++  
Sbjct: 679 MQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQE 738

Query: 460 TEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSEL---EQAKEEQS--HTQALLKV 514
            EE + + ++  + Q+     Q++ +  Q+ L  +K +L   E+ +E++     +  ++ 
Sbjct: 739 QEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRD 798

Query: 515 LQEQLKGTKE 524
            +E+++G +E
Sbjct: 799 QEEKMRGQEE 808



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 36/175 (20%), Positives = 78/175 (44%), Gaps = 4/175 (2%)

Query: 369 QRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYA 428
           ++K +    +  +E      EQ   +R +EE     +E      K+MR  E  +  Q   
Sbjct: 339 EQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEER 398

Query: 429 LKEENDSLRWQLDAYRNEVELLKQ----EKEQLFRTEENLTKDQQLQFLQQTMQGMQQQL 484
           + E+++ LR + +  R + ++ +Q     +E+  + +E  T+DQ+ +  ++     +++ 
Sbjct: 399 MWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKK 458

Query: 485 LTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEI 539
           +  +EE   ++ E  Q +EE    Q   +  Q++L   KE +       E   +I
Sbjct: 459 MREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKI 513



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 23/128 (17%), Positives = 70/128 (54%), Gaps = 1/128 (0%)

Query: 397 EEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQ 456
           +EEM   ++E  +   KK+R  E  +  Q   L+E+   +R Q +    + + L++++++
Sbjct: 271 QEEMWRQEEELREQE-KKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKE 329

Query: 457 LFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQ 516
           L   E+ L + ++L+  ++ MQ  ++++   +E++  ++ ++ + +E     +  ++  +
Sbjct: 330 LREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQE 389

Query: 517 EQLKGTKE 524
           ++++  +E
Sbjct: 390 QKMRDQEE 397



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 49/279 (17%), Positives = 116/279 (41%), Gaps = 38/279 (13%)

Query: 228 WECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLL 287
           WE +++M  +EE+     E+ RL    P       EHE     EK+++  +         
Sbjct: 641 WEQEEKMWEQEEK---MWEQQRL----PEQKEKLWEHEKMQEQEKMQEQEE--------K 685

Query: 288 SWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFE 347
            W E+ ++ +++  Q               M E+   E++M E +E  +     +  Q E
Sbjct: 686 IW-EQEKMEKKTQEQEKKTWDQEKMREEESMRER---EKKMREEEEMMREQEEKMQEQEE 741

Query: 348 QIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEM--SDD 405
           ++         ++ W+   K   +   +W    ++    Q E+L    + +E E     +
Sbjct: 742 KM-----QEQEEEMWEQEEKMWEQEEKMWE---QQRLPEQKEKLWEHEKMQEQEKIWEQE 793

Query: 406 ENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLT 465
           E      +KMR  E  +  Q   ++ + + +  Q +    + E +  ++E+++  EE   
Sbjct: 794 EKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEK-- 851

Query: 466 KDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEE 504
                  +++ MQG ++++   +E++  ++ ++ + +E+
Sbjct: 852 -------MEEKMQGQEEKMREQEEKMRGQEEKMREQEEK 883


>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
           sapiens]
          Length = 570

 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 88/422 (20%), Positives = 168/422 (39%), Gaps = 36/422 (8%)

Query: 163 EQCGDITAIRKSKKNFCHIRFAEEFMVDK-AIYLSGYRMRLGSSTDKKDSGRLHVDFAQA 221
           EQ     A +K K +    R+ EE   ++ A+ L  YR  +     K+ + +L     Q 
Sbjct: 166 EQALSAVATQKKKAD----RYIEELTKERDALSLELYRNTITDEELKEKNAKL-----QE 216

Query: 222 RDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEH---EAALLAEKLKDDSK 278
           +    E E K  ++   +  +RKLE  +L  P    +   ++H   E   ++ KL+   +
Sbjct: 217 KLQLVESE-KSEIQLNVKELKRKLERAKLLLPQQQ-LQAEADHLGKELQSVSAKLQAQVE 274

Query: 279 FSEAITVLLS------WIERGEVNRRSAN--QFYSMVQSANSHVRRL------MNEKATH 324
            +E    L        W +  ++  R     +    ++     +RR         EK   
Sbjct: 275 ENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRR 334

Query: 325 EQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELR 384
           ++EM   KE     L   + + E+I         ++      K Q +   +WR+  E++R
Sbjct: 335 QEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQE-EKIR 393

Query: 385 NAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYR 444
               EQ   IR +EEM    +E      +KM   E  +  Q   ++ + + +R Q    R
Sbjct: 394 ----EQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIR 449

Query: 445 NEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEE 504
            + E +++++E +   EE + + +     Q+     Q++ +  QEE   ++ +  + +EE
Sbjct: 450 EQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEE 509

Query: 505 QSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKS 564
           +   Q   +++QEQ +   E  E      E   E          + RE  +  R Q  K 
Sbjct: 510 KIREQE--EMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKM 567

Query: 565 EK 566
           ++
Sbjct: 568 QE 569


>gi|45439327 periplakin [Homo sapiens]
          Length = 1756

 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 48/181 (26%), Positives = 90/181 (49%), Gaps = 20/181 (11%)

Query: 355  ASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKK 414
            AS R K     S+ Q+K +D+ R+     R +Q EQ+   R+EEE+    +        +
Sbjct: 1309 ASLRAK----LSEEQKKQVDLERE-----RASQEEQIA--RKEEELSRVKERVVQQEVVR 1357

Query: 415  MRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQ----- 469
               +E  L A+A A  E  D    Q+D  R E+  L++ + +L R  E L +++Q     
Sbjct: 1358 YE-EEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARREA 1416

Query: 470  ---LQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELV 526
               +Q LQQ +  ++Q+    +E++ + +  + Q   +Q+   ALL++  E+ +  ++L+
Sbjct: 1417 EREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLL 1476

Query: 527  E 527
            E
Sbjct: 1477 E 1477



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 85/358 (23%), Positives = 141/358 (39%), Gaps = 59/358 (16%)

Query: 232  QRMRAREERHRRKLEEDRLRPPS---PPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLS 288
            +R RA +E    + EE+  R         ++ Y E E  L AE     S F+E+I V L 
Sbjct: 1326 ERERASQEEQIARKEEELSRVKERVVQQEVVRYEE-EPGLRAEA----SAFAESIDVELR 1380

Query: 289  WIE--RGEVNR--RSANQFYSMVQS----------ANSHVRRLMNEKATHEQEMEEAKEN 334
             I+  R E+ R  R   +    ++           A   V+RL    A  EQE  EA+E 
Sbjct: 1381 QIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAALEQEEAEAREK 1440

Query: 335  FKNALTGILTQFEQIV---AVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQL 391
              +    +L Q  Q     A+      ++   H  +     ++  R+    L  A+ ++ 
Sbjct: 1441 VTHTQKVVLQQDPQQAREHALLRLQLEEE--QHRRQLLEGELETLRRKLAALEKAEVKEK 1498

Query: 392  MGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVEL-- 449
            + +    ++E  D E      K    +ES         K E D    +L+A  +E+E   
Sbjct: 1499 VVLSESVQVEKGDTEQEIQRLKSSLEEES-------RSKRELDVEVSRLEARLSELEFHN 1551

Query: 450  LKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAK-----EE 504
             K  KE  F  EEN         LQ   Q +Q +   +Q E+N   +E    +     + 
Sbjct: 1552 SKSSKELDFLREEN-------HKLQLERQNLQLETRRLQSEINMAATETRDLRNMTVADS 1604

Query: 505  QSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVL-----TVALVNQDRENNIEK 557
             ++  + L  L+ +L   K L      S +   EI+ L     +VA+  + REN++ +
Sbjct: 1605 GTNHDSRLWSLERELDDLKRL------SKDKDLEIDELQKRLGSVAVKREQRENHLRR 1656



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 56/233 (24%), Positives = 105/233 (45%), Gaps = 26/233 (11%)

Query: 314  VRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWD-----HFSKA 368
            +R+ ++E+    +++E   ++ +  +  +  Q  Q  +V      +K  D      F + 
Sbjct: 895  IRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQ-ESVVRKEVLKKVPDPVLEESFQQL 953

Query: 369  QRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVD-ESALAAQAY 427
            QR   +   +H  +L   + E L    R  E E  D        + +R++ + A A +  
Sbjct: 954  QRTLAE--EQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEVL 1011

Query: 428  ALKEENDSLRWQLDAYRNEVELLKQE----KEQLFRTEENLTK--------DQQL----Q 471
             L+EE ++LR Q  A   EV LL+Q      E+  R +E +T+        D QL    Q
Sbjct: 1012 QLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQ 1071

Query: 472  FLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKE 524
             LQ+  Q   Q     +EEL+  + +L++ ++E++  +  + V +E LK  K+
Sbjct: 1072 QLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITV-KEVLKVEKD 1123



 Score = 30.8 bits (68), Expect = 4.0
 Identities = 40/226 (17%), Positives = 95/226 (42%), Gaps = 28/226 (12%)

Query: 305 SMVQSANSHVRRLMNEKATHEQEMEEAKEN---FKNALTGILTQFEQIVAVFNASTRQKA 361
           S +++   + + L++E A+ EQE+++   N   ++ A+     + E++ ++ +    + +
Sbjct: 761 SQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLENGRSS 820

Query: 362 WDHFSKAQRKNIDIWR-KHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDES 420
             H SK  R      + K  E    A+  ++  I R+    +    N      ++ V   
Sbjct: 821 --HVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHE 878

Query: 421 AL--------AAQAYALKEENDSLRWQLDAYRNEVELLKQE--------------KEQLF 458
            L          +A+ +++E D    +     NEV+  ++E              ++++ 
Sbjct: 879 TLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVL 938

Query: 459 RTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEE 504
           +   +   ++  Q LQ+T+   Q +   +QEEL   + +L   ++E
Sbjct: 939 KKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQE 984


>gi|114155142 nuclear pore complex-associated protein TPR [Homo
           sapiens]
          Length = 2363

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 58/239 (24%), Positives = 102/239 (42%), Gaps = 38/239 (15%)

Query: 359 QKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRRE----EEMEMSDDENCDSPTKK 414
           Q   + F   Q+  ID  +   E+ +    +Q   I +     +E  +++   C S    
Sbjct: 22  QNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQS---- 77

Query: 415 MRVDESALAAQAYALKEENDSLRWQLDA-------YRNEVELLKQEKEQLFRTEENLTKD 467
           +R++   L  Q  AL E+N  L    D        +    E L+ EK  L RT E L+  
Sbjct: 78  LRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLS-- 135

Query: 468 QQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVE 527
           Q+L++L + ++ + ++L    +E N  K EL+   +E   +   +K  +++L+  KEL+ 
Sbjct: 136 QELEYLTEDVKRLNEKL----KESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLH 191

Query: 528 TNGH----------------SHEDSNEINVLTVALVNQDRE-NNIEKRSQGLKSEKEAL 569
           +                     E  NEI  L   L N+  E + +E++  GLK+  E L
Sbjct: 192 SQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHL 250



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 77/368 (20%), Positives = 154/368 (41%), Gaps = 68/368 (18%)

Query: 232  QRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEK--LKDDSKFSEAITVLLSW 289
            Q+M+A+     RKLE D L  P   A    SE    L AEK  L++D K  +A       
Sbjct: 1291 QQMQAKV----RKLELDIL--PLQEANAELSEKSGMLQAEKKLLEEDVKRWKA------- 1337

Query: 290  IERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQI 349
                    R+ +             R+L++EK  H + +++        LT  + + +  
Sbjct: 1338 --------RNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQ--------LTEEIGRLKAE 1381

Query: 350  VAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCD 409
            +A  NAS       +  ++ +++++  R   E ++     +++ I+ +    +       
Sbjct: 1382 IARSNASLTNN--QNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEK----VKTITQVK 1435

Query: 410  SPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTE-ENLTKDQ 468
               ++ +     L AQ   + E +             V+ +++ KE L + E ++ + + 
Sbjct: 1436 KIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLES 1495

Query: 469  QLQFLQQTM-------QGMQQQLLTIQEELNNKKSELEQ--AKEEQSHTQ---------- 509
            Q++ LQ+T+       + +Q+Q + +Q EL+  + +L+    +EEQ   Q          
Sbjct: 1496 QVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRK 1555

Query: 510  ---------ALLKVLQEQL-KGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKRS 559
                     A L  +++QL K  +EL + NG   +  +E++V   AL +Q  E  I +  
Sbjct: 1556 AIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQ-YEGRISRLE 1614

Query: 560  QGLKSEKE 567
            + L+  +E
Sbjct: 1615 RELREHQE 1622



 Score = 36.6 bits (83), Expect = 0.073
 Identities = 64/340 (18%), Positives = 133/340 (39%), Gaps = 52/340 (15%)

Query: 271  EKLKDDS--KFSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEM 328
            EK++++   K  E +T L S   +       A++ Y M+Q      RR +       Q++
Sbjct: 690  EKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKL 749

Query: 329  E---EAKENFKNALTGILTQFEQIVAVFNAST----RQKAWDHFSK---AQRKNIDIWRK 378
                + +E   N +T  L    + +AV         ++K     S+   +Q++   +  +
Sbjct: 750  TATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQ 809

Query: 379  HSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRW 438
              + L     + + GI    E E    +   S  +K+  + S L  +     E+  +L  
Sbjct: 810  RGQNLLLTNLQTIQGILERSETETK--QRLSSQIEKLEHEISHLKKKLENEVEQRHTLTR 867

Query: 439  QLDA---------------YRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQ----- 478
             LD                + N  ELLK  ++++   +++L+ + ++Q   Q+ Q     
Sbjct: 868  NLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLS-NMEVQVASQSSQRTGKG 926

Query: 479  ---------GMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETN 529
                      +  QL   +E++N+ K  L+ +       QA++  L+E L   K++ E  
Sbjct: 927  QPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTE-- 984

Query: 530  GHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEAL 569
                      N+      + + +  +EK+   ++ EK+ L
Sbjct: 985  ------EVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQEL 1018



 Score = 36.2 bits (82), Expect = 0.096
 Identities = 47/227 (20%), Positives = 102/227 (44%), Gaps = 26/227 (11%)

Query: 299 SANQFYSMVQSANSHVRRLMNEKATHE-QEMEEAKENFKNALTGILTQFEQI-------V 350
           S  Q++ + +  +    RL+NE  T E Q +    E   N L  +  + +++       +
Sbjct: 50  SEQQYFEIEKRLSHSQERLVNE--TRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNI 107

Query: 351 AVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELR---------NAQSEQLMGIRREEEME 401
           A+ +  TR K  +     +R  I    + S+EL          N + ++    + E +++
Sbjct: 108 AIQSQFTRTK--EELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLK 165

Query: 402 MSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEK-EQLFRT 460
           + + +  D   K     E  L  +   L  +N  L  +L    +E+  L +EK  ++   
Sbjct: 166 LDELQASDVSVKYR---EKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILEL 222

Query: 461 EENL-TKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQS 506
           + NL  K +++  L++ M G++     +Q+ + +  ++L++AKE+Q+
Sbjct: 223 KCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQA 269



 Score = 36.2 bits (82), Expect = 0.096
 Identities = 55/269 (20%), Positives = 113/269 (42%), Gaps = 31/269 (11%)

Query: 263  EHEAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKA 322
            EHE + L +KL+++ +            +R  + R    Q     +  ++     +N K 
Sbjct: 845  EHEISHLKKKLENEVE------------QRHTLTRNLDVQLLDTKRQLDTETNLHLNTKE 892

Query: 323  ---THEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKH 379
                 ++E+   K++  N    + +Q  Q       S ++   D  S+ ++    +    
Sbjct: 893  LLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQV---- 948

Query: 380  SEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQ 439
              +L+         + + + M  S +E+ +   K+ +V E         LKE  +  + Q
Sbjct: 949  -NDLKERLKTSTSNVEQYQAMVTSLEESLN---KEKQVTEEVRKNIEVRLKESAE-FQTQ 1003

Query: 440  LDAYRNEVELLKQE-KEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSEL 498
            L+    EVE  KQE ++   R  E++  +QQL  L++T+  +Q +   +QE L    + L
Sbjct: 1004 LEKKLMEVEKEKQELQDDKRRAIESM--EQQLSELKKTLSSVQNE---VQEALQRASTAL 1058

Query: 499  EQAKEEQSHTQALLKV-LQEQLKGTKELV 526
               ++ +   Q   K+ ++ Q K  +EL+
Sbjct: 1059 SNEQQARRDCQEQAKIAVEAQNKYERELM 1087



 Score = 33.9 bits (76), Expect = 0.48
 Identities = 36/150 (24%), Positives = 69/150 (46%), Gaps = 6/150 (4%)

Query: 380  SEELRNAQS--EQLMGIRREEEMEMSDDE--NCDSPTKKMRVD--ESALAAQAYALKEEN 433
            SEE ++ +   E L  IRRE+E+  +  E    +S   + RV+  E  L     +L  E 
Sbjct: 1187 SEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAER 1246

Query: 434  DSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNN 493
            + ++          EL+K+ +      E N    ++ + L+Q +Q MQ ++  ++ ++  
Sbjct: 1247 EKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILP 1306

Query: 494  KKSELEQAKEEQSHTQALLKVLQEQLKGTK 523
             +    +  E+    QA  K+L+E +K  K
Sbjct: 1307 LQEANAELSEKSGMLQAEKKLLEEDVKRWK 1336



 Score = 33.1 bits (74), Expect = 0.81
 Identities = 43/218 (19%), Positives = 90/218 (41%), Gaps = 13/218 (5%)

Query: 291 ERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFK-NALTGILTQFEQI 349
           E GE N+   +    + QS +   + ++ +    E+E+E A +        G +   E++
Sbjct: 316 EAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEEL 375

Query: 350 VAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEM-EMSDDENC 408
            A+   S    A     K   K  +++  + E       E+L   R  + + E+  +   
Sbjct: 376 AAM---SPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEA 432

Query: 409 DSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQ 468
            +P  K + +E   A +A A      SL  +L+    E++ L+++ ++  +    L +D 
Sbjct: 433 KAPILKRQREEYERAQKAVA------SLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDN 486

Query: 469 QLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQS 506
           +   +Q  ++ + QQ+  +  EL   +       EE S
Sbjct: 487 RRMEIQ--VKDLSQQIRVLLMELEEARGNHVIRDEEVS 522



 Score = 32.7 bits (73), Expect = 1.1
 Identities = 34/134 (25%), Positives = 53/134 (39%), Gaps = 4/134 (2%)

Query: 439 QLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSEL 498
           ++D  +   E  K E EQ +   E      Q + + +T +   Q L    E+LNN+   L
Sbjct: 35  EIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETREC--QSLRLELEKLNNQLKAL 92

Query: 499 EQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQD--RENNIE 556
            +  +E    Q     +Q Q   TKE +E        +NE     +  + +D  R N   
Sbjct: 93  TEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKL 152

Query: 557 KRSQGLKSEKEALL 570
           K S   K E +  L
Sbjct: 153 KESNTTKGELQLKL 166


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 69/347 (19%), Positives = 150/347 (43%), Gaps = 33/347 (9%)

Query: 229  ECKQRMRAREERHRRKLEEDR--LRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVL 286
            + ++R+R REE+ R++LE+ R  L   S       +E +A + AE     +K  E +   
Sbjct: 1031 DLEERLR-REEKQRQELEKTRRKLEGDSTDLSDQIAELQAQI-AELKMQLAKKEEELQAA 1088

Query: 287  LSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQF 346
            L+ +E     +  A +    ++S  S ++  +  +     + E+ K +    L  + T+ 
Sbjct: 1089 LARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTEL 1148

Query: 347  EQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDE 406
            E  +          A       + + ++I +K  EE       Q+  +R++    + +  
Sbjct: 1149 EDTL------DSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELA 1202

Query: 407  NCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEK---EQLFRTEEN 463
                 TK+++ +          L++   +L  +     NEV++L Q K   E   +  E 
Sbjct: 1203 EQLEQTKRVKAN----------LEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEA 1252

Query: 464  LTKDQQLQFLQ--QTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKG 521
              ++ Q++F +  +    +  ++  +Q EL+N    L Q+  + S        L+ QL+ 
Sbjct: 1253 QLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQD 1312

Query: 522  TKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEA 568
            T+EL++      E+  ++++ T     +D +N+  ++   L+ E+EA
Sbjct: 1313 TQELLQ-----EENRQKLSLSTKLKQVEDEKNSFREQ---LEEEEEA 1351



 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 40/138 (28%), Positives = 71/138 (51%), Gaps = 10/138 (7%)

Query: 381 EELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQL 440
           EEL   + +QL    R  EME    +      +K+++ E   A     L  E + LR +L
Sbjct: 852 EELVKVREKQLAAENRLTEMETLQSQLM---AEKLQLQEQLQAETE--LCAEAEELRARL 906

Query: 441 DAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQ 500
            A + E+E +  + E   R EE   ++++ Q LQ   + MQQ +  ++E+L  ++S  ++
Sbjct: 907 TAKKQELEEICHDLEA--RVEE---EEERCQHLQAEKKKMQQNIQELEEQLEEEESARQK 961

Query: 501 AKEEQSHTQALLKVLQEQ 518
            + E+  T+A LK L+E+
Sbjct: 962 LQLEKVTTEAKLKKLEEE 979



 Score = 46.2 bits (108), Expect = 9e-05
 Identities = 84/361 (23%), Positives = 143/361 (39%), Gaps = 79/361 (21%)

Query: 220  QARDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKF 279
            Q RD+  E + KQ +R   E    +LE++R +              A    +KL+ D K 
Sbjct: 1574 QGRDEQSEEKKKQLVRQVREMEA-ELEDERKQ-----------RSMAVAARKKLEMDLKD 1621

Query: 280  SEAITVLLSWIERGEVNRRSA-NQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKN- 337
             EA       I+    NR  A  Q   +       +R L + +A+ E+ + +AKEN K  
Sbjct: 1622 LEA------HIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKL 1675

Query: 338  -ALTGILTQFEQIVAVFNASTRQ------KAWDHFSKAQRKN-IDIWRKHSEELRNAQSE 389
             ++   + Q ++ +A    + RQ      +  D  + +  K  + +  K   E R AQ E
Sbjct: 1676 KSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLE 1735

Query: 390  QLMGIRREEEMEMSDDENCDSPTKKM-----RVDESALAAQAYALKEENDSLRWQLDAYR 444
            +      E E E  + E  +   KK      +++      +++A K EN   R QL+   
Sbjct: 1736 E------ELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNEN--ARQQLERQN 1787

Query: 445  NEVELLKQEKE-------------------QLFRTEENLTKDQQLQFLQ--QTMQGMQQQ 483
             E+++  QE E                   QL    +N TK++Q    Q  +T + ++  
Sbjct: 1788 KELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDV 1847

Query: 484  LLTIQEELNNK-----------------KSELEQAKEEQSHTQALLKVLQEQLKGTKELV 526
            LL + +E  N                  K +LE+A+EE     A  + LQ +L+   E  
Sbjct: 1848 LLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETA 1907

Query: 527  E 527
            +
Sbjct: 1908 D 1908



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 65/303 (21%), Positives = 127/303 (41%), Gaps = 45/303 (14%)

Query: 297  RRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKE--------NFKNALTGILTQFEQ 348
            +++  +    ++   S  ++L  EK T E ++++ +E        N K A    L   E 
Sbjct: 942  QQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKL--LED 999

Query: 349  IVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENC 408
             +A F  +  ++     S A+ KN     KH   + + +      +RREE+      +  
Sbjct: 1000 RIAEFTTNLTEEEEKSKSLAKLKN-----KHEAMITDLEER----LRREEKQR----QEL 1046

Query: 409  DSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVEL-LKQEKEQLFRTEENLTK- 466
            +   +K+  D + L+ Q   L+ +   L+ QL     E++  L + +E+  +    L K 
Sbjct: 1047 EKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKI 1106

Query: 467  ---DQQLQFLQQTMQG-------MQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQ 516
               + Q+  LQ+ ++         ++Q   + EEL   K+ELE   +  +  Q L    +
Sbjct: 1107 RELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKRE 1166

Query: 517  EQLKGTKELVETNGHSHE---------DSNEINVLTVALVNQDR-ENNIEKRSQGLKSEK 566
            +++   K+ +E    +HE          S  +  L   L    R + N+EK  Q L++E+
Sbjct: 1167 QEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENER 1226

Query: 567  EAL 569
              L
Sbjct: 1227 GEL 1229



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 72/359 (20%), Positives = 146/359 (40%), Gaps = 45/359 (12%)

Query: 242  RRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSAN 301
            +++ + D+L          Y+E      AE  + ++K       L   +E+     R   
Sbjct: 1441 KKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNK 1500

Query: 302  QFYSMVQSANSH-------VRRLMNEKATHEQEMEEAK------ENFKNALTGILTQFEQ 348
            QF + ++   S        V  L   K   EQ++EE K      E+   A      + E 
Sbjct: 1501 QFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEV 1560

Query: 349  IVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSE---ELRNAQSEQLMGIRREEEMEM--- 402
             +    A   +       +++ K   + R+  E   EL + + ++ M +   +++EM   
Sbjct: 1561 NLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLK 1620

Query: 403  -------SDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKE 455
                   S ++N D   K++R     L AQ      E D  R    A R E+    +E E
Sbjct: 1621 DLEAHIDSANKNRDEAIKQLR----KLQAQMKDCMRELDDTR----ASREEILAQAKENE 1672

Query: 456  QLFRT--EENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLK 513
            +  ++   E +   ++L   ++  +  QQ+   + +E+ N   +   A EE+   +A + 
Sbjct: 1673 KKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIA 1732

Query: 514  VLQEQL---KGTKELV-----ETNGHSHEDSNEINV-LTVALVNQDRENNIEKRSQGLK 563
             L+E+L   +G  EL+     + N    + + ++N+  + A  N++    +E++++ LK
Sbjct: 1733 QLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELK 1791



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 63/340 (18%), Positives = 151/340 (44%), Gaps = 43/340 (12%)

Query: 263  EHEAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKA 322
            ++   LL++     SK ++  + L S ++  +   +  N+      S ++ ++++ +EK 
Sbjct: 1283 DNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENR---QKLSLSTKLKQVEDEKN 1339

Query: 323  THEQEMEEAKENFKNALTGILTQFEQIVAV-----FNASTRQKAWDHFSKAQRKNIDIWR 377
            +  +++EE +E   N    I T   Q+  +      +    + A +   K Q+    + +
Sbjct: 1340 SFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQ 1399

Query: 378  KHSEELRNAQSEQLMGIRREEEMEMSD---------DENCDSPTKKMRVDESALAAQAYA 428
            +H E++  A  ++L   +   + E+ D            C+   K+ + D+     +  +
Sbjct: 1400 RHEEKV--AAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTIS 1457

Query: 429  LKEENDSLRWQLDAYRNEVELL------------KQEKEQL---FRTE-ENL--TKD--- 467
             K   +  R + +A   E + L            K E E+L   FRTE E+L  +KD   
Sbjct: 1458 AKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVG 1517

Query: 468  QQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVE 527
            + +  L+++ + ++QQ+  ++ +L   + EL+  ++ +   +  L+ ++ Q +  ++L  
Sbjct: 1518 KSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFE--RDLQG 1575

Query: 528  TNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKE 567
             +  S E   ++ V  V  +  + E+  ++RS  + + K+
Sbjct: 1576 RDEQSEEKKKQL-VRQVREMEAELEDERKQRSMAVAARKK 1614



 Score = 38.5 bits (88), Expect = 0.019
 Identities = 42/172 (24%), Positives = 82/172 (47%), Gaps = 20/172 (11%)

Query: 380  SEELR---NAQSEQLMGIRREEEMEMSDDE----NCDSPTKKMRVDESALAAQAYALKEE 432
            +EELR    A+ ++L  I  + E  + ++E    +  +  KKM+ +   L  Q    +EE
Sbjct: 899  AEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLE--EEE 956

Query: 433  NDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELN 492
            +   + QL+    E +L K E+EQ+   ++N    ++ + L+  +       LT +EE +
Sbjct: 957  SARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTN-LTEEEEKS 1015

Query: 493  NKKSELEQAKEEQSHTQALLKVLQEQL----KGTKELVETNGHSHEDSNEIN 540
               ++L+   E      A++  L+E+L    K  +EL +T      DS +++
Sbjct: 1016 KSLAKLKNKHE------AMITDLEERLRREEKQRQELEKTRRKLEGDSTDLS 1061



 Score = 37.0 bits (84), Expect = 0.056
 Identities = 36/160 (22%), Positives = 63/160 (39%), Gaps = 28/160 (17%)

Query: 440 LDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEE--------- 490
           L   R E E++ +E+E +   E+ L  + +L  ++     +  + L +QE+         
Sbjct: 838 LQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCA 897

Query: 491 --------LNNKKSEL-----------EQAKEEQSHTQALLKVLQEQLKGTKELVETNGH 531
                   L  KK EL           E+ +E   H QA  K +Q+ ++  +E +E    
Sbjct: 898 EAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEES 957

Query: 532 SHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEALLI 571
           + +      V T A + +  E  I    Q  K  KE  L+
Sbjct: 958 ARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLL 997


>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
          Length = 1088

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 77/387 (19%), Positives = 162/387 (41%), Gaps = 49/387 (12%)

Query: 232 QRMRAREERH-------RRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKD---DSKFSE 281
           QR+ A  ER        R+ LEE  LR  +    ++  +     L E L+     +K +E
Sbjct: 268 QRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATE 327

Query: 282 AITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHE---------QEMEEAK 332
                   +   E++           +  NS +R  M+ +  +          Q + E K
Sbjct: 328 EDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMK 387

Query: 333 ENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLM 392
           ++  +++   L   E+ + +  ++      +   + + K ++++R HS+ ++N   +   
Sbjct: 388 DSKISSMERGLRDLEEEIQMLKSNGALSTEER--EEEMKQMEVYRSHSKFMKNKIGQVKQ 445

Query: 393 GIRREE--------EMEMSDDENCDSPTKKMRVDESALAAQAYA--LKEENDSLRWQLDA 442
            + R++        ++E   ++  DS      + ES  A +  A  L+ E D+LR +L+ 
Sbjct: 446 ELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLE- 504

Query: 443 YRNEVELLKQEKEQLFRTEENLT--------------KDQQLQFLQQTMQGMQQQLLTIQ 488
              E  L K+ K+     EE  T              K++++  LQ+ ++ +Q+QL   +
Sbjct: 505 -EKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKE 563

Query: 489 EELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVN 548
           +++++ K  ++  + + ++T   L  L+E L   +  +E      +         +    
Sbjct: 564 KQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYK 623

Query: 549 QDRENNIEKRS--QGLKSEKEALLIGI 573
           +D ++  EK S  QG  SEKEA L+ +
Sbjct: 624 KDLKDLKEKVSLLQGDLSEKEASLLDL 650



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 46/274 (16%), Positives = 107/274 (39%), Gaps = 28/274 (10%)

Query: 294 EVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVF 353
           +V  R  N     +++    +R    + ++ ++ ++  + +  N  T + T  E +    
Sbjct: 539 DVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKE 598

Query: 354 NASTRQKAW-DHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPT 412
               R K   D   + +++ ID ++K  ++L+   S  L G   E+E  + D        
Sbjct: 599 RTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVS-LLQGDLSEKEASLLD-------- 649

Query: 413 KKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQF 472
               + E A +  +  LK+++     ++         L+Q+KE+  + E  L K  +   
Sbjct: 650 ----LKEHASSLASSGLKKDSRLKTLEI--------ALEQKKEECLKMESQLKKAHEAAL 697

Query: 473 LQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHS 532
             +    M  ++  ++ E+   K E  +A+ E      +LK ++ +     + +      
Sbjct: 698 EARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQ 757

Query: 533 HEDSNEINVLTVALVNQDRENNIEKRSQGLKSEK 566
            +D N+       + N   +  +EK+      E+
Sbjct: 758 VKDQNK------KVANLKHKEQVEKKKSAQMLEE 785


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 73/304 (24%), Positives = 128/304 (42%), Gaps = 39/304 (12%)

Query: 231 KQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWI 290
           +Q++R RE++ RR+ EE+R          H  +HE     ++LK + +          W+
Sbjct: 416 EQQLR-REQQLRREQEEER----------HEQKHEQERREQRLKREQEERR------DWL 458

Query: 291 ERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIV 350
           +R E   R   +        +    R        E+E  E +E  +  L     + EQ  
Sbjct: 459 KREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQL-----RREQEE 513

Query: 351 AVFNASTRQKAWDHFSKAQRKNIDIWRKHSEE----LRNAQSEQLMGIRREEEMEMSDDE 406
                  RQ+  +   +  R    + R+  E     L+  + ++L   RRE+ ++   +E
Sbjct: 514 RREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEE 573

Query: 407 NCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQE---KEQLFRTEEN 463
             D   K  R +E     Q    +E+ + L  +L   R EVE L+QE   +++L R E  
Sbjct: 574 RRDQLLK--REEERR---QQRLKREQEERLEQRLK--REEVERLEQEERREQRLKREEPE 626

Query: 464 LTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTK 523
             + QQL   ++  +  QQQL   Q+E   ++ + E   EE+   +  LK   E+ +  +
Sbjct: 627 EERRQQLLKSEEQEERRQQQLRREQQERREQRLKRE---EEEERLEQRLKREHEEERREQ 683

Query: 524 ELVE 527
           EL E
Sbjct: 684 ELAE 687



 Score = 53.5 bits (127), Expect = 6e-07
 Identities = 61/298 (20%), Positives = 128/298 (42%), Gaps = 25/298 (8%)

Query: 231  KQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEK-LKDDSKFSEAITVLLSW 289
            ++  R R+E+ R+  EE++L+      +    E       E+  + D K  +    LL  
Sbjct: 917  EREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLG- 975

Query: 290  IERGEVNRRSANQF-YSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQ 348
             E  E  RR   +  Y   +       +L+ E+    +  E  ++  K     +  + EQ
Sbjct: 976  -EEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKK--DELQQEEEQ 1032

Query: 349  IVAVFNASTR----QKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSD 404
            ++       R    ++ +    + Q++   +  +  E  R  + E+    R+EEE++  +
Sbjct: 1033 LLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQY--RKEEELQQEE 1090

Query: 405  DENC-DSPTKKMRVDESALAAQAYALKEENDSL---------RWQLDAYRNEVELLKQEK 454
            ++   + P K+ R +      +   L++E + L         R +L+    E E ++QE+
Sbjct: 1091 EQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEE 1150

Query: 455  EQLFRTEENLTKDQQLQFL---QQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQ 509
            EQL R E    + Q+L+     ++ +Q  ++QLL  ++E   ++ E +  +EE+   Q
Sbjct: 1151 EQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQ 1208



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 83/387 (21%), Positives = 151/387 (39%), Gaps = 66/387 (17%)

Query: 213 RLHVDFAQARDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEK 272
           RL     Q RD+   W  +Q  + REER   + EE++L+         + + E     E 
Sbjct: 160 RLEQRDRQRRDEEL-WRQRQEWQEREER---RAEEEQLQSCKGHETEEFPDEEQLRRREL 215

Query: 273 LKDDSKFSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAK 332
           L+   K  E         E+ +  R   ++ +   +      R  +  K   + + EE +
Sbjct: 216 LELRRKGRE---------EKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQ 266

Query: 333 ENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLM 392
              +     +  + EQ+  +     R++  +   + QR       +  ++LR  Q E+  
Sbjct: 267 RQRE-----LQEEEEQLRKLERQELRRERQEEEQQQQRL------RREQQLRRKQEEE-- 313

Query: 393 GIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQ 452
             RRE++ E  + +      ++ R  E  L  +    +E+   LR + +  R E +L ++
Sbjct: 314 --RREQQEERREQQERREQQEERR--EQQLRREQEERREQQ--LRREQEEERREQQLRRE 367

Query: 453 EKEQLFRTEENLTKDQQLQFLQQTMQGMQ----------------------QQLLTIQEE 490
           ++E+  R E+ L ++QQL+  QQ  +  Q                      QQL   Q+ 
Sbjct: 368 QEEE--RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 425

Query: 491 LNNKKSELEQAKEEQSHTQALLKVLQEQLKG-TKELVETNGHSHE---------DSNEIN 540
              ++ E  + K EQ   +  LK  QE+ +   K   ET  H  E            E  
Sbjct: 426 RREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERR 485

Query: 541 VLTVALVNQDRENNIEKRSQGLKSEKE 567
              + L  ++R    E+R Q L+ E+E
Sbjct: 486 ERWLKLEEEERREQQERREQQLRREQE 512



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 72/369 (19%), Positives = 140/369 (37%), Gaps = 28/369 (7%)

Query: 207 DKKDSGRLHVDFAQARDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEA 266
           ++++  R   +  + +++  E + ++    R E+  R+ +E+  R             E 
Sbjct: 316 EQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQ 375

Query: 267 ALLAEK-LKDDSKFSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHE 325
            L  E+ L+ + +      +      R E   R   Q     Q       R   E+  HE
Sbjct: 376 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHE 435

Query: 326 Q--EMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEEL 383
           Q  E E  ++  K          ++          ++        + +  + W K  EE 
Sbjct: 436 QKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEE 495

Query: 384 RNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDE--SALAAQAYALKEENDSLRWQLD 441
           R  Q E     RRE+++    +E  +   K+   +E           L+ E +  R QL 
Sbjct: 496 RREQQE-----RREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLL 550

Query: 442 AYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNN---KKSEL 498
               E  L ++ +EQ  + E+   +DQ    L++  +  QQ+L   QEE      K+ E+
Sbjct: 551 KREEEKRLEQERREQRLKREQEERRDQ---LLKREEERRQQRLKREQEERLEQRLKREEV 607

Query: 499 EQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKR 558
           E+ ++E+   Q L +   E+ +  ++L+++         ++           R    E+R
Sbjct: 608 ERLEQEERREQRLKREEPEE-ERRQQLLKSEEQEERRQQQL-----------RREQQERR 655

Query: 559 SQGLKSEKE 567
            Q LK E+E
Sbjct: 656 EQRLKREEE 664



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 71/382 (18%), Positives = 152/382 (39%), Gaps = 36/382 (9%)

Query: 208 KKDSGRLHVDFAQARDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAA 267
           K++  R      + +++  E   K+    R E+  R+  E RL+   P       E    
Sbjct: 580 KREEERRQQRLKREQEERLEQRLKREEVERLEQEERR--EQRLKREEPE-----EERRQQ 632

Query: 268 LLAEKLKDDSKFSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQE 327
           LL  + +++ +  +   +     ER E   +   +   + Q           E+   E+E
Sbjct: 633 LLKSEEQEERRQQQ---LRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEE 689

Query: 328 MEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQ 387
            E+A+E  K+ +     Q E       +    +      + +R+  +  R+  E     Q
Sbjct: 690 QEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQ 749

Query: 388 SEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEV 447
            E+    +++EE +  D        +K       L+A+    ++    LR + +  + E 
Sbjct: 750 EEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAE-ERQQREQ 808

Query: 448 ELLKQEKEQLFRTEENLTKDQQLQFLQ--------QTMQGMQQQLLTIQEELNNKKS--- 496
             L +E+E+  R  +   ++++LQFL+        +  Q +Q++   +QE+   ++S   
Sbjct: 809 RFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQ 868

Query: 497 --------ELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVN 548
                   +LE+ ++ + HT      LQEQL+  ++L++      E+  E+         
Sbjct: 869 RRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQ------EEEEELQREEREKRR 922

Query: 549 QDRENNIEKRSQGLKSEKEALL 570
           +  +    +  + L+ E+E LL
Sbjct: 923 RQEQERQYREEEQLQQEEEQLL 944



 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 69/325 (21%), Positives = 131/325 (40%), Gaps = 34/325 (10%)

Query: 220  QARDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKF 279
            Q RD  +  E +Q ++ REE+   + E DR      P +    E E  L  ++   D KF
Sbjct: 1615 QERDRKFR-EDEQLLQEREEQQLHRQERDRKFLEEEPQLRR-QEREQQLRHDR---DRKF 1669

Query: 280  SEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNAL 339
             E   +L    + GE  +    +     +     +RR   E+   ++E +  ++  +   
Sbjct: 1670 REEEQLL----QEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKF 1725

Query: 340  TG---ILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRR 396
                 +  + EQ         R+   +   + +R+   + R+   + +  + EQL   R 
Sbjct: 1726 REEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQL-RRQERDRKFREEEQLRQERE 1784

Query: 397  EEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQ 456
            E+++   + +      +++R +      Q    ++ +   RW+      E +L  +E+EQ
Sbjct: 1785 EQQLRSQESDRKFREEEQLRQEREE---QQLRPQQRDGKYRWE------EEQLQLEEQEQ 1835

Query: 457  LFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELE----------QAKEEQS 506
              R E +     + QF  Q     ++Q L  QEE   ++ E E          Q KEEQ 
Sbjct: 1836 RLRQERDRQYRAEEQFATQEKSRREEQELW-QEEEQKRRQERERKLREEHIRRQQKEEQR 1894

Query: 507  HTQALLKVLQEQLKGTKELVETNGH 531
            H Q + ++  ++ KG   L+E   H
Sbjct: 1895 HRQ-VGEIKSQEGKGHGRLLEPGTH 1918



 Score = 46.2 bits (108), Expect = 9e-05
 Identities = 85/376 (22%), Positives = 149/376 (39%), Gaps = 69/376 (18%)

Query: 220  QARDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKD-DSK 278
            Q RD  ++W+ +++     ER R++L     RPP         + E  L AE+ +  + +
Sbjct: 763  QRRDFTWQWQAEEK----SERGRQRLSA---RPPLR------EQRERQLRAEERQQREQR 809

Query: 279  FSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNA 338
            F       L   E  E  RR   +    +Q      +    E+A   QE E+        
Sbjct: 810  F-------LPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDG------- 855

Query: 339  LTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQL---MGIR 395
                  Q +Q         R + W    + +RK     R+H+   + A  EQL     + 
Sbjct: 856  -----LQEDQERRRSQEQRRDQKWRWQLEEERKR----RRHTLYAKPALQEQLRKEQQLL 906

Query: 396  REEEMEMSDDEN----CDSPTKKMRVDESALAAQAYALKEENDSLRWQLDA--YRNEVEL 449
            +EEE E+  +E          ++ R +E     +   L+EE +  R Q     YR + +L
Sbjct: 907  QEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKL 966

Query: 450  L---------------KQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNK 494
                            +QE+E+ +R EE L ++++ Q L++  +  ++Q     E    K
Sbjct: 967  QQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEE-QLLREEREKRRRQEW---ERQYRK 1022

Query: 495  KSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENN 554
            K EL+Q +E+    +   + LQE+ +  +E  E      E+   +         Q+ E  
Sbjct: 1023 KDELQQEEEQLLREEREKRRLQERERQYREEEEL---QQEEEQLLGEERETRRRQELERQ 1079

Query: 555  IEKRSQGLKSEKEALL 570
              K  + L+ E+E LL
Sbjct: 1080 YRKEEE-LQQEEEQLL 1094



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 71/367 (19%), Positives = 147/367 (40%), Gaps = 40/367 (10%)

Query: 220  QARDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKD---- 275
            Q++ D      +Q+ R RE+  RR  + DR          H+ E E  L  E+ K+    
Sbjct: 1262 QSQQDLQHLLGEQQERDREQERRRWQQRDR----------HFPEEEQ-LEREEQKEAKRR 1310

Query: 276  DSKFSEAITVLLSWIE----RGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEA 331
            D K  E   +L    E    R E +R+   +   + +     +RR   ++   E+E+   
Sbjct: 1311 DRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQ 1370

Query: 332  KENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQL 391
            ++  K        + ++    F    +Q       +  R++ D  RK  EE +    ++ 
Sbjct: 1371 EQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRD--RKFREEEQQLSRQER 1428

Query: 392  MGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYR------- 444
                REEE ++   E      +K   +E  L  + +    E + L  + +  +       
Sbjct: 1429 DRKFREEEQQVRRQER----ERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERD 1484

Query: 445  -----NEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELE 499
                  E +L +QE+++ FR +E  +++ + +FL++  Q  +QQ    Q +   ++ +L 
Sbjct: 1485 RKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQR---QRKFLQEEQQLR 1541

Query: 500  QAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKRS 559
            + +  Q   Q   +  +E+ +  +E  E      E   +  +    +  Q++E    +  
Sbjct: 1542 RQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDE 1601

Query: 560  QGLKSEK 566
            Q L+ ++
Sbjct: 1602 QQLRRQE 1608



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 71/373 (19%), Positives = 147/373 (39%), Gaps = 60/373 (16%)

Query: 227  EWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVL 286
            E + ++    REER +R+L+E   +        +  E E     E+L  + + +     L
Sbjct: 1025 ELQQEEEQLLREEREKRRLQERERQ--------YREEEELQQEEEQLLGEERETRRRQEL 1076

Query: 287  LSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENF------KNALT 340
                 + E  ++   Q   + +      R+    +   E+E+++ +E        K    
Sbjct: 1077 ERQYRKEEELQQEEEQL--LREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQ 1134

Query: 341  GILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGI-----R 395
             +  Q+ +   V      Q   +   K +R+ ++   +  EEL+  + EQL+       R
Sbjct: 1135 ELERQYREEEEV-QQEEEQLLREEPEKRRRQELERQYREEEELQQ-EEEQLLREEQEKRR 1192

Query: 396  REEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYR------NEVEL 449
            +E E +  ++E      +K R          Y  +++   L+WQ +  +      N+V  
Sbjct: 1193 QERERQYREEEELQRQKRKQR----------YRDEDQRSDLKWQWEPEKENAVRDNKVYC 1242

Query: 450  LKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQ-------------EELNNKKS 496
              +E EQ  + E++  +D+Q Q   Q + G QQ+    Q             EE   ++ 
Sbjct: 1243 KGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLERE 1302

Query: 497  ELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIE 556
            E ++AK     +Q   ++L+E+ +  +   ET+    E+          L+ +  E  + 
Sbjct: 1303 EQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQ--------LLQEREEQPLR 1354

Query: 557  KRSQGLKSEKEAL 569
            ++ +  K  +E L
Sbjct: 1355 RQERDRKFREEEL 1367



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 68/366 (18%), Positives = 141/366 (38%), Gaps = 53/366 (14%)

Query: 208 KKDSGRLHVDFAQARDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAA 267
           +K+  +L  +  Q + +  E E + R   R+E  R + EE++                  
Sbjct: 254 RKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQ---------QQQRLRREQ 304

Query: 268 LLAEKLKDDSKFSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQE 327
            L  K +++ +            E+ E  R    +     +     +RR   E+   +  
Sbjct: 305 QLRRKQEEERR------------EQQEERREQQERREQQEERREQQLRREQEERREQQLR 352

Query: 328 MEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQ 387
            E+ +E  +  L     +  +   +      ++      + Q +     R+  +  R  Q
Sbjct: 353 REQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ 412

Query: 388 SEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEV 447
             +   +RRE+++    +E       +    E  L  +    +E  D L+ + +  R+E 
Sbjct: 413 LRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQ---EERRDWLKREEETERHEQ 469

Query: 448 ELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQ----QQLLTIQEELNNKKSELEQAKE 503
           E   + K+QL R +E   +++ L+  ++  +  Q    QQL   QEE   ++  L++ +E
Sbjct: 470 E---RRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEE--RREQRLKRQEE 524

Query: 504 EQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNI--EKRSQG 561
           E+         LQ++L+  ++L        E           L+ ++ E  +  E+R Q 
Sbjct: 525 EER--------LQQRLRSEQQLRREQEERREQ----------LLKREEEKRLEQERREQR 566

Query: 562 LKSEKE 567
           LK E+E
Sbjct: 567 LKREQE 572



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 79/355 (22%), Positives = 145/355 (40%), Gaps = 69/355 (19%)

Query: 229  ECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLS 288
            E +QR+R R+ER R+ L+E++         +   E E  L  ++   D KF E       
Sbjct: 1378 EEEQRLR-RQERERKFLKEEQQ--------LRCQEREQQLRQDR---DRKFRE------- 1418

Query: 289  WIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQ 348
              E  +++R+  ++ +   +     VRR   E+   E+E +  +E  +        + EQ
Sbjct: 1419 --EEQQLSRQERDRKF---REEEQQVRRQERERKFLEEEQQLRQERHRK-----FREEEQ 1468

Query: 349  IVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENC 408
            ++       R++   H  +  RK ++      ++LR  + +     R+  E E+   E  
Sbjct: 1469 LL-----QEREEQQLHRQERDRKFLE----EEQQLRRQERD-----RKFREQELRSQE-- 1512

Query: 409  DSPTKKMRVDESALAAQAYALK--EENDSLRWQ---------LDAYRNEVELLKQEKE-- 455
              P +K   +E  L  Q    K  +E   LR Q          D    E E L+QE+E  
Sbjct: 1513 --PERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQ 1570

Query: 456  QLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVL 515
            QL R E    +D++ +  +Q ++  +Q+   +++E      +L + + +Q   Q   +  
Sbjct: 1571 QLSRQE----RDRKFRLEEQKVRRQEQERKFMEDE-----QQLRRQEGQQQLRQERDRKF 1621

Query: 516  QEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEALL 570
            +E  +  +E  E   H  E   +       L  Q+RE  +         E+E LL
Sbjct: 1622 REDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLL 1676



 Score = 38.1 bits (87), Expect = 0.025
 Identities = 49/244 (20%), Positives = 99/244 (40%), Gaps = 19/244 (7%)

Query: 235  RAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKL--KDDSKFSEAITVLLSWIER 292
            R R+ER ++  EE+ L+      +    E       E+   K D    E   +L    E+
Sbjct: 981  RRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREK 1040

Query: 293  GEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAV 352
              +  R     Y   +       +L+ E+    +  E  ++  K     +  + EQ++  
Sbjct: 1041 RRLQERERQ--YREEEELQQEEEQLLGEERETRRRQELERQYRKEE--ELQQEEEQLLRE 1096

Query: 353  F----NASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENC 408
                     R++      + Q++   + R+  E+ R  + E+    R EEE++  +++  
Sbjct: 1097 EPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQY--REEEEVQQEEEQLL 1154

Query: 409  -DSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKD 467
             + P K+ R +      +   L++E + L       R E E  +QE+E+ +R EE L + 
Sbjct: 1155 REEPEKRRRQELERQYREEEELQQEEEQL------LREEQEKRRQERERQYREEEELQRQ 1208

Query: 468  QQLQ 471
            ++ Q
Sbjct: 1209 KRKQ 1212


>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
            sapiens]
          Length = 1843

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 63/301 (20%), Positives = 127/301 (42%), Gaps = 27/301 (8%)

Query: 242  RRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSAN 301
            R KL E +L      ++    E + A L  +L++ + +++ +   L  +++     +   
Sbjct: 953  RYKLLESKLESTLKKSL-EIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQ 1011

Query: 302  QFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKA 361
                MVQS+      +  E    E+E +E           +L   ++++ V   +   +A
Sbjct: 1012 DEERMVQSSPP----ISGEDNKWERESQETTRE-------LLKVKDRLIEVERNNATLQA 1060

Query: 362  WDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESA 421
                 K Q K +       E   N    Q++ ++R+       +    +   K++V+ S 
Sbjct: 1061 EKQALKTQLKQL-------ETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENST 1113

Query: 422  LAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKD-QQLQFLQQTMQGM 480
            L +Q+ +L  +N  L  Q  +  NE E + +E+E L    ++L KD ++L+ L +     
Sbjct: 1114 LNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASE 1173

Query: 481  QQQLLTIQEELN--NKKSELEQAKEEQSHTQAL-----LKVLQEQLKGTKELVETNGHSH 533
             + L++    L   +K  E+E    E  + Q L     L+ L++ LK  +E +     +H
Sbjct: 1174 YESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNH 1233

Query: 534  E 534
            E
Sbjct: 1234 E 1234



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 68/354 (19%), Positives = 148/354 (41%), Gaps = 44/354 (12%)

Query: 232 QRMRAREERHRRKLEEDRLR-PPSPPAIMHYSEHEAALLAEKLKDDSKF-SEAITVLLSW 289
           + +R   ER  + LE++      +  ++   S+  A    + ++ ++K   E+I    S 
Sbjct: 543 ETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSK 602

Query: 290 IERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQI 349
           + + E  +R   +     +        L NE       +E+  E  +  +T +    E+I
Sbjct: 603 LSKIEFEKRQIKKELEHYKEKGERAEELENEL----HHLEKENELLQKKITNLKITCEKI 658

Query: 350 VAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCD 409
            A+   ++     +  ++  +K +D ++  + +L +           E+E    D+EN +
Sbjct: 659 EALEQENSEL---ERENRKLKKTLDSFKNLTFQLESL----------EKENSQLDEENLE 705

Query: 410 SPTKKMRVDESALAAQAYA-LKEENDSLRWQLDAYRNEVELLKQ---------------- 452
               +  V+    A+   A L+ EN  L  + +  +  +ELLK                 
Sbjct: 706 L---RRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLD 762

Query: 453 -EKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQAL 511
            E ++L +T EN  K  ++Q L+  +Q ++ +  T+Q+ L   K   ++ ++ +   ++L
Sbjct: 763 IENQRLQKTLENSNK--KIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSL 820

Query: 512 LKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSE 565
            +   +  K  K+L + N    + + EI   T+   N  +  N+EK ++ L  E
Sbjct: 821 EQETSQLEKDKKQLEKENKRLRQQA-EIKDTTLE-ENNVKIGNLEKENKTLSKE 872



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 60/285 (21%), Positives = 124/285 (43%), Gaps = 13/285 (4%)

Query: 295 VNRRSANQFYSM-VQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILT-QFEQIVAV 352
           + R  + Q  S+ +  A + +RRL  E     +++ + K+  +     +   Q E +  +
Sbjct: 240 MKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLL 299

Query: 353 FNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPT 412
            +A + +   D     + K + + +  SE  R  +    +   +    E+ +D      T
Sbjct: 300 SDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLET 359

Query: 413 KKMRVDE----SALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQ 468
           K M  D+     A + + + L++EN  L+ +L     E ++ +++ E+L   EEN+T + 
Sbjct: 360 KTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELM--EENMTLEM 417

Query: 469 -QLQFLQQTMQ-GMQQQLLTIQEELNN--KKSELEQAKEEQSHTQALLKVLQEQLKGTKE 524
            Q Q + +++  G + + ++   EL+   +KS   +  E  S     L++  + L  T E
Sbjct: 418 AQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVE 477

Query: 525 LVETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEAL 569
            + T   S E  N   +L +   NQ     +E     +  EK++L
Sbjct: 478 ELRTTVDSVE-GNASKILKMEKENQRLSKKVEILENEIVQEKQSL 521



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 73/360 (20%), Positives = 153/360 (42%), Gaps = 58/360 (16%)

Query: 229 ECKQRMRARE-ERHRRKLEEDRLRPPSPPAIMHYSE----HEAALLAEKLKDD-SKFSEA 282
           +CKQ +   E E  R + E   L   +  A M+  E     E A+  +KL+ + S++ E 
Sbjct: 276 DCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKER 335

Query: 283 ITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGI 342
           +  +               +FY          +  + E     Q + E K   ++ L G 
Sbjct: 336 LHDI---------------EFY----------KARVEELKEDNQVLLETKTMLEDQLEGT 370

Query: 343 LTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRN-------AQSEQL---M 392
             + +++  +   + + KA  H  + +R   D+ RK  EEL         AQ + +   +
Sbjct: 371 RARSDKLHELEKENLQLKAKLHDMEMER---DMDRKKIEELMEENMTLEMAQKQSMDESL 427

Query: 393 GIRREEEMEMSDDENCDSPTKKMRVDESAL-AAQAYALKEENDSLRWQLDAYRNEVE--- 448
            +  E E      E  ++P K +  + + L +++   L+ EN SL   ++  R  V+   
Sbjct: 428 HLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVE 487

Query: 449 -----LLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKE 503
                +LK EKE    +++    + ++   +Q++Q  Q     + ++L  +K++LE+  E
Sbjct: 488 GNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQ----NLSKDLMKEKAQLEKTIE 543

Query: 504 E-QSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGL 562
             + +++  +K+L+++ +   + V +     + S E  V  +   N+    +I++ S  L
Sbjct: 544 TLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKL 603



 Score = 38.5 bits (88), Expect = 0.019
 Identities = 83/494 (16%), Positives = 202/494 (40%), Gaps = 47/494 (9%)

Query: 151 ENATEEIIQEVFEQCGDITAIRKSKKNFCHIRFAEEFMVDKAIYLSGYRMRLGSSTDKKD 210
           +N ++++++E  +    I  +R++ +    I   E   +++ +     R ++ +    KD
Sbjct: 525 QNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKD 584

Query: 211 SGR----LHVDFAQARDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEA 266
             +    LH    +      + E ++R   +E  H ++  E   R       +H+ E E 
Sbjct: 585 IEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGE---RAEELENELHHLEKEN 641

Query: 267 ALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQ 326
            LL +K+ +     E I  L       E   R   +     ++    +  L  E +  ++
Sbjct: 642 ELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDE 701

Query: 327 EMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNA 386
           E  E + N ++     +   +            K  +   +  +K +++ +   ++    
Sbjct: 702 ENLELRRNVESLKCASMKMAQ-------LQLENKELESEKEQLKKGLELLKASFKKTERL 754

Query: 387 Q-SEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRN 445
           + S Q + I  +   +  ++ N     KK++  ES L      L+ EN +L+  L+    
Sbjct: 755 EVSYQGLDIENQRLQKTLENSN-----KKIQQLESELQD----LEMENQTLQKNLE---- 801

Query: 446 EVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQ 505
           E+++  +  EQL   +EN + +Q+   L++  + ++++   ++++   K + LE+   + 
Sbjct: 802 ELKISSKRLEQL--EKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKI 859

Query: 506 SHTQALLKVLQEQLKGTKELVETNGHSHEDSNE------INVLTVALVNQDRENNIEKRS 559
            + +   K L +++   KE         +++ E      I++ T+  + +D  +  + ++
Sbjct: 860 GNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSE-KLKT 918

Query: 560 QGLKSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQLDS---KISANEIEMLLMRLPRM 616
           Q + ++ E L          +   G N E L    Q  D    K+  +++E  L +   +
Sbjct: 919 QQMNNDLEKLT-------HELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEI 971

Query: 617 FKQEFTGVGATLEK 630
            +++   + A LE+
Sbjct: 972 KEEKIAALEARLEE 985



 Score = 38.5 bits (88), Expect = 0.019
 Identities = 50/219 (22%), Positives = 93/219 (42%), Gaps = 33/219 (15%)

Query: 317  LMNEKATHEQEMEEAKEN-FKNALTGILTQFEQIVAVFNASTRQKAW----DHFSKAQRK 371
            L++E+   E E   +K    K+A   +  +   +   +N   +QK      +   K +++
Sbjct: 1165 LLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQE 1224

Query: 372  NIDIWRKHSEELRNAQSEQLMG-----------IRREEEMEMSDDENCDSPTKKMRVDES 420
             + +  K+ E +  A+ ++L G           + +E E+  +D +N  S     +++++
Sbjct: 1225 KMLLENKNHETVA-AEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQT 1283

Query: 421  ALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQ--------F 472
             L A+   LKE+   L        N+ ELL Q K  L   EEN     Q+Q         
Sbjct: 1284 RLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNL--EEENRHLLDQIQTLMLQNRTL 1341

Query: 473  LQQTMQGM------QQQLLTIQEELNNKKSELEQAKEEQ 505
            L+Q M+        Q+Q +    EL  +K +LE+   +Q
Sbjct: 1342 LEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQ 1380



 Score = 35.0 bits (79), Expect = 0.21
 Identities = 45/210 (21%), Positives = 93/210 (44%), Gaps = 25/210 (11%)

Query: 370 RKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKK-------MRVDESAL 422
           ++ ID   +HSE +    SE+  G+        S    C SP  K       + V+ +  
Sbjct: 198 KRLIDERDEHSETIIEL-SEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADA 256

Query: 423 AAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKD--------QQLQFLQ 474
            A+   L++E +    QL   + E+E ++ E ++L +   NL  D         +L  L+
Sbjct: 257 KAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALR 316

Query: 475 Q---TMQGMQQQLLTIQEELNN---KKSELEQAKEEQSHTQALLKVLQEQLKGTKELVET 528
           +    +  ++ ++   +E L++    K+ +E+ KE+         +L++QL+GT+     
Sbjct: 317 EKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTR---AR 373

Query: 529 NGHSHEDSNEINVLTVALVNQDRENNIEKR 558
           +   HE   E   L   L + + E +++++
Sbjct: 374 SDKLHELEKENLQLKAKLHDMEMERDMDRK 403



 Score = 29.6 bits (65), Expect = 9.0
 Identities = 63/300 (21%), Positives = 120/300 (40%), Gaps = 46/300 (15%)

Query: 281  EAITVLLSWIERGEVNRRSANQFYSMVQSANSHV----RRLMNEKATHEQEMEEAKENFK 336
            E + +    +E+ E   +S  Q  S ++     +    +RL  +    +  +EE      
Sbjct: 801  EELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIG 860

Query: 337  NALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRR 396
            N      T  ++I     +  R K  +  +K   K   I  K    LR    E L+  + 
Sbjct: 861  NLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLR----EDLVSEKL 916

Query: 397  EEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVEL-----LK 451
            + +   +D E      +K+ +++  L       ++  D  R++L   + E  L     +K
Sbjct: 917  KTQQMNNDLEKLTHELEKIGLNKERLLHD----EQSTDDSRYKLLESKLESTLKKSLEIK 972

Query: 452  QEKEQLF--RTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQ 509
            +EK      R EE+   +QQL          +Q+L T+++        L+Q ++E+   Q
Sbjct: 973  EEKIAALEARLEESTNYNQQL----------RQELKTVKKNY----EALKQRQDEERMVQ 1018

Query: 510  ALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEAL 569
            +   +  E  K  +E       S E + E+      L  +DR   +E+ +  L++EK+AL
Sbjct: 1019 SSPPISGEDNKWERE-------SQETTREL------LKVKDRLIEVERNNATLQAEKQAL 1065


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
            sapiens]
          Length = 1870

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 63/301 (20%), Positives = 127/301 (42%), Gaps = 27/301 (8%)

Query: 242  RRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSAN 301
            R KL E +L      ++    E + A L  +L++ + +++ +   L  +++     +   
Sbjct: 952  RYKLLESKLESTLKKSL-EIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQ 1010

Query: 302  QFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKA 361
                MVQS+      +  E    E+E +E           +L   ++++ V   +   +A
Sbjct: 1011 DEERMVQSSPP----ISGEDNKWERESQETTRE-------LLKVKDRLIEVERNNATLQA 1059

Query: 362  WDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESA 421
                 K Q K +       E   N    Q++ ++R+       +    +   K++V+ S 
Sbjct: 1060 EKQALKTQLKQL-------ETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENST 1112

Query: 422  LAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKD-QQLQFLQQTMQGM 480
            L +Q+ +L  +N  L  Q  +  NE E + +E+E L    ++L KD ++L+ L +     
Sbjct: 1113 LNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASE 1172

Query: 481  QQQLLTIQEELN--NKKSELEQAKEEQSHTQAL-----LKVLQEQLKGTKELVETNGHSH 533
             + L++    L   +K  E+E    E  + Q L     L+ L++ LK  +E +     +H
Sbjct: 1173 YESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNH 1232

Query: 534  E 534
            E
Sbjct: 1233 E 1233



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 68/354 (19%), Positives = 148/354 (41%), Gaps = 44/354 (12%)

Query: 232 QRMRAREERHRRKLEEDRLR-PPSPPAIMHYSEHEAALLAEKLKDDSKF-SEAITVLLSW 289
           + +R   ER  + LE++      +  ++   S+  A    + ++ ++K   E+I    S 
Sbjct: 543 ETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSK 602

Query: 290 IERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQI 349
           + + E  +R   +     +        L NE       +E+  E  +  +T +    E+I
Sbjct: 603 LSKIEFEKRQIKKELEHYKEKGERAEELENEL----HHLEKENELLQKKITNLKITCEKI 658

Query: 350 VAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCD 409
            A+   ++     +  ++  +K +D ++  + +L +           E+E    D+EN +
Sbjct: 659 EALEQENSEL---ERENRKLKKTLDSFKNLTFQLESL----------EKENSQLDEENLE 705

Query: 410 SPTKKMRVDESALAAQAYA-LKEENDSLRWQLDAYRNEVELLKQ---------------- 452
               +  V+    A+   A L+ EN  L  + +  +  +ELLK                 
Sbjct: 706 L---RRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLD 762

Query: 453 -EKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQAL 511
            E ++L +T EN  K  ++Q L+  +Q ++ +  T+Q+ L   K   ++ ++ +   ++L
Sbjct: 763 IENQRLQKTLENSNK--KIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSL 820

Query: 512 LKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSE 565
            +   +  K  K+L + N    + + EI   T+   N  +  N+EK ++ L  E
Sbjct: 821 EQETSQLEKDKKQLEKENKRLRQQA-EIKDTTLE-ENNVKIGNLEKENKTLSKE 872



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 60/285 (21%), Positives = 124/285 (43%), Gaps = 13/285 (4%)

Query: 295 VNRRSANQFYSM-VQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILT-QFEQIVAV 352
           + R  + Q  S+ +  A + +RRL  E     +++ + K+  +     +   Q E +  +
Sbjct: 240 MKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLL 299

Query: 353 FNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPT 412
            +A + +   D     + K + + +  SE  R  +    +   +    E+ +D      T
Sbjct: 300 SDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLET 359

Query: 413 KKMRVDE----SALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQ 468
           K M  D+     A + + + L++EN  L+ +L     E ++ +++ E+L   EEN+T + 
Sbjct: 360 KTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELM--EENMTLEM 417

Query: 469 -QLQFLQQTMQ-GMQQQLLTIQEELNN--KKSELEQAKEEQSHTQALLKVLQEQLKGTKE 524
            Q Q + +++  G + + ++   EL+   +KS   +  E  S     L++  + L  T E
Sbjct: 418 AQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVE 477

Query: 525 LVETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEAL 569
            + T   S E  N   +L +   NQ     +E     +  EK++L
Sbjct: 478 ELRTTVDSVE-GNASKILKMEKENQRLSKKVEILENEIVQEKQSL 521



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 73/360 (20%), Positives = 153/360 (42%), Gaps = 58/360 (16%)

Query: 229 ECKQRMRARE-ERHRRKLEEDRLRPPSPPAIMHYSE----HEAALLAEKLKDD-SKFSEA 282
           +CKQ +   E E  R + E   L   +  A M+  E     E A+  +KL+ + S++ E 
Sbjct: 276 DCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKER 335

Query: 283 ITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGI 342
           +  +               +FY          +  + E     Q + E K   ++ L G 
Sbjct: 336 LHDI---------------EFY----------KARVEELKEDNQVLLETKTMLEDQLEGT 370

Query: 343 LTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRN-------AQSEQL---M 392
             + +++  +   + + KA  H  + +R   D+ RK  EEL         AQ + +   +
Sbjct: 371 RARSDKLHELEKENLQLKAKLHDMEMER---DMDRKKIEELMEENMTLEMAQKQSMDESL 427

Query: 393 GIRREEEMEMSDDENCDSPTKKMRVDESAL-AAQAYALKEENDSLRWQLDAYRNEVE--- 448
            +  E E      E  ++P K +  + + L +++   L+ EN SL   ++  R  V+   
Sbjct: 428 HLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVE 487

Query: 449 -----LLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKE 503
                +LK EKE    +++    + ++   +Q++Q  Q     + ++L  +K++LE+  E
Sbjct: 488 GNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQ----NLSKDLMKEKAQLEKTIE 543

Query: 504 E-QSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGL 562
             + +++  +K+L+++ +   + V +     + S E  V  +   N+    +I++ S  L
Sbjct: 544 TLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKL 603



 Score = 38.9 bits (89), Expect = 0.015
 Identities = 83/493 (16%), Positives = 202/493 (40%), Gaps = 46/493 (9%)

Query: 151 ENATEEIIQEVFEQCGDITAIRKSKKNFCHIRFAEEFMVDKAIYLSGYRMRLGSSTDKKD 210
           +N ++++++E  +    I  +R++ +    I   E   +++ +     R ++ +    KD
Sbjct: 525 QNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKD 584

Query: 211 SGR----LHVDFAQARDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEA 266
             +    LH    +      + E ++R   +E  H ++  E   R       +H+ E E 
Sbjct: 585 IEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGE---RAEELENELHHLEKEN 641

Query: 267 ALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQ 326
            LL +K+ +     E I  L       E   R   +     ++    +  L  E +  ++
Sbjct: 642 ELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDE 701

Query: 327 EMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNA 386
           E  E + N ++     +   +            K  +   +  +K +++ +   ++    
Sbjct: 702 ENLELRRNVESLKCASMKMAQ-------LQLENKELESEKEQLKKGLELLKASFKKTERL 754

Query: 387 Q-SEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRN 445
           + S Q + I  +   +  ++ N     KK++  ES L      L+ EN +L+  L+    
Sbjct: 755 EVSYQGLDIENQRLQKTLENSN-----KKIQQLESELQD----LEMENQTLQKNLE---- 801

Query: 446 EVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQ 505
           E+++  +  EQL   +EN + +Q+   L++  + ++++   ++++   K + LE+   + 
Sbjct: 802 ELKISSKRLEQL--EKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKI 859

Query: 506 SHTQALLKVLQEQLKGTKELVETNGHSHEDSNE------INVLTVALVNQDRENNIEKRS 559
            + +   K L +++   KE         +++ E      I++ T+  + +D  +  + ++
Sbjct: 860 GNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSE-KLKT 918

Query: 560 QGLKSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQLDS--KISANEIEMLLMRLPRMF 617
           Q + ++ E L          +   G N E L    Q  D   K+  +++E  L +   + 
Sbjct: 919 QQMNNDLEKLT-------HELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIK 971

Query: 618 KQEFTGVGATLEK 630
           +++   + A LE+
Sbjct: 972 EEKIAALEARLEE 984



 Score = 38.5 bits (88), Expect = 0.019
 Identities = 50/219 (22%), Positives = 93/219 (42%), Gaps = 33/219 (15%)

Query: 317  LMNEKATHEQEMEEAKEN-FKNALTGILTQFEQIVAVFNASTRQKAW----DHFSKAQRK 371
            L++E+   E E   +K    K+A   +  +   +   +N   +QK      +   K +++
Sbjct: 1164 LLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQE 1223

Query: 372  NIDIWRKHSEELRNAQSEQLMG-----------IRREEEMEMSDDENCDSPTKKMRVDES 420
             + +  K+ E +  A+ ++L G           + +E E+  +D +N  S     +++++
Sbjct: 1224 KMLLENKNHETVA-AEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQT 1282

Query: 421  ALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQ--------F 472
             L A+   LKE+   L        N+ ELL Q K  L   EEN     Q+Q         
Sbjct: 1283 RLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNL--EEENRHLLDQIQTLMLQNRTL 1340

Query: 473  LQQTMQGM------QQQLLTIQEELNNKKSELEQAKEEQ 505
            L+Q M+        Q+Q +    EL  +K +LE+   +Q
Sbjct: 1341 LEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQ 1379



 Score = 35.0 bits (79), Expect = 0.21
 Identities = 45/210 (21%), Positives = 93/210 (44%), Gaps = 25/210 (11%)

Query: 370 RKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKK-------MRVDESAL 422
           ++ ID   +HSE +    SE+  G+        S    C SP  K       + V+ +  
Sbjct: 198 KRLIDERDEHSETIIEL-SEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADA 256

Query: 423 AAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKD--------QQLQFLQ 474
            A+   L++E +    QL   + E+E ++ E ++L +   NL  D         +L  L+
Sbjct: 257 KAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALR 316

Query: 475 Q---TMQGMQQQLLTIQEELNN---KKSELEQAKEEQSHTQALLKVLQEQLKGTKELVET 528
           +    +  ++ ++   +E L++    K+ +E+ KE+         +L++QL+GT+     
Sbjct: 317 EKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTR---AR 373

Query: 529 NGHSHEDSNEINVLTVALVNQDRENNIEKR 558
           +   HE   E   L   L + + E +++++
Sbjct: 374 SDKLHELEKENLQLKAKLHDMEMERDMDRK 403



 Score = 32.0 bits (71), Expect = 1.8
 Identities = 60/295 (20%), Positives = 118/295 (40%), Gaps = 37/295 (12%)

Query: 281  EAITVLLSWIERGEVNRRSANQFYSMVQSANSHV----RRLMNEKATHEQEMEEAKENFK 336
            E + +    +E+ E   +S  Q  S ++     +    +RL  +    +  +EE      
Sbjct: 801  EELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIG 860

Query: 337  NALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRR 396
            N      T  ++I     +  R K  +  +K   K   I  K    LR    E L+  + 
Sbjct: 861  NLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLR----EDLVSEKL 916

Query: 397  EEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQ 456
            + +   +D E      +K+ +++  L     +  +    L  +L++   +   +K+EK  
Sbjct: 917  KTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIA 976

Query: 457  LF--RTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKV 514
                R EE+   +QQL          +Q+L T+++        L+Q ++E+   Q+   +
Sbjct: 977  ALEARLEESTNYNQQL----------RQELKTVKKNY----EALKQRQDEERMVQSSPPI 1022

Query: 515  LQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEAL 569
              E  K  +E       S E + E+      L  +DR   +E+ +  L++EK+AL
Sbjct: 1023 SGEDNKWERE-------SQETTREL------LKVKDRLIEVERNNATLQAEKQAL 1064


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 57/225 (25%), Positives = 101/225 (44%), Gaps = 26/225 (11%)

Query: 370 RKNIDIWRKHSEELRNAQSEQLMGIRREEEM--EMSDDENC---------------DSPT 412
           R+ ++      E LR  Q+E    + R E+   E+S  EN                 +  
Sbjct: 546 REALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALN 605

Query: 413 KKMRVDESALAAQAYALKEENDSLRWQLDAYRN-----EVELLKQEKEQLFRTEENLTKD 467
           + + +D+  L  Q   L+EEN S+  +++A        +V+L + EK +    E+N   +
Sbjct: 606 EALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLE 665

Query: 468 QQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVE 527
            QLQ  ++    +Q  L  IQEE    + +L +++ +Q      L+ L ++ K  +E++ 
Sbjct: 666 AQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLA 725

Query: 528 TNGHSHED-SNEINVLTVAL--VNQDRENNIEKRSQGLKSEKEAL 569
                 E    E   L V L  V +DR+ ++ ++ QGL S KE L
Sbjct: 726 RAVQEKEALVREKAALEVRLQAVERDRQ-DLAEQLQGLSSAKELL 769



 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 88/420 (20%), Positives = 172/420 (40%), Gaps = 62/420 (14%)

Query: 208 KKDSGRLHVDFAQARDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAI---MHYSEH 264
           ++D  +L VD+++ARD+    E + +M     +   K E  RL       +    H+ E 
Sbjct: 135 REDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEM 194

Query: 265 EAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLM------ 318
           ++A   + ++  ++       LL+   R  V  +S     S         + L+      
Sbjct: 195 KSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQ 254

Query: 319 -NEKATHE--QEMEEAKENFKNALTGILTQFEQIVAVFNASTRQ-KAWDHFSKAQRKNID 374
             EK  HE  QE+ + K         +  +  ++ A+   S +Q + ++   KA R+ ++
Sbjct: 255 ELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVE 314

Query: 375 IWRKHSEEL--------RNAQSEQL---------------------MGIRREEEMEMS-- 403
           I   +  EL        RNAQ E+L                      G   E  +E+   
Sbjct: 315 ILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSS 374

Query: 404 -----DDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLF 458
                D ++ D   K + +  S L  +  A+++    LR QL   +  V LL+Q+ +Q  
Sbjct: 375 IFSQFDYQDAD---KALTLVRSVLTRRRQAVQD----LRQQLAGCQEAVNLLQQQHDQW- 426

Query: 459 RTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQ 518
             EE     Q+LQ L      +  Q + +Q E+++   E E  ++ +   +  L+VL+++
Sbjct: 427 -EEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQE 485

Query: 519 ---LKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEALLIGIIS 575
              L+     ++  G S +   E     + L  ++RE  +++   GL++++   L  +I+
Sbjct: 486 AWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERE-RLQEMLMGLEAKQSESLSELIT 544



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 62/297 (20%), Positives = 123/297 (41%), Gaps = 24/297 (8%)

Query: 266 AALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHE 325
           +ALL +  K +  + + I  L   +E  E N     +  + + S N+   +L  ++   +
Sbjct: 289 SALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASL-SRNAQEEKLSLQQVIKD 347

Query: 326 --QEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEEL 383
             Q M E  +N     +G     E   ++F+    Q A D      R  +   R+  ++L
Sbjct: 348 ITQVMVEEGDNIAQG-SGHENSLELDSSIFSQFDYQDA-DKALTLVRSVLTRRRQAVQDL 405

Query: 384 RNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAY 443
           R    +QL G +    +     +  +   K +R     L  +   L  +   L+ ++D+ 
Sbjct: 406 R----QQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSL 461

Query: 444 RNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKE 503
             E ELL++ +E+L          QQL+ L+Q    +++  + +Q + ++ + + E+ +E
Sbjct: 462 SKERELLQKAREEL---------RQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQE 512

Query: 504 EQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQ 560
           E        + LQE L G +          E  +E+  L  AL +   E  + ++ Q
Sbjct: 513 ELHLAVRERERLQEMLMGLE------AKQSESLSELITLREALESSHLEGELLRQEQ 563



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 62/315 (19%), Positives = 133/315 (42%), Gaps = 37/315 (11%)

Query: 263  EHEAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKA 322
            E E   L  +LK+     EAI       +R E   ++ +    M          L+    
Sbjct: 881  EREKMELEMRLKEQQTEMEAIQA-----QREEERTQAESALCQMQLETEKERVSLLETLL 935

Query: 323  THEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEE 382
              ++E+ +A +  +      L Q  ++  +    T         +AQR+  +  R+H ++
Sbjct: 936  QTQKELADASQQLER-----LRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDD 990

Query: 383  LRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDA 442
            L   Q E    ++ + +++   +   D  ++ +  D+S    Q    +E  + LR   + 
Sbjct: 991  LAALQEESSSLLQDKMDLQKQVE---DLKSQLVAQDDS----QRLVEQEVQEKLRETQEY 1043

Query: 443  YRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAK 502
             R + EL   E+E+   T   + K+Q+L  LQ+     QQ+L  +++       ++++A+
Sbjct: 1044 NRIQKEL---EREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQ-------DMQEAQ 1093

Query: 503  EEQSHTQALLKVLQEQLKGTK--------ELVETNGHSHEDSNEINVLTVALVNQDRENN 554
             EQ    A +++L++++K  +        +L+E    SH    ++     A   + +   
Sbjct: 1094 GEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWA--QEAKAAQ 1151

Query: 555  IEKRSQGLKSEKEAL 569
            ++ R +  +S+ EAL
Sbjct: 1152 LQLRLRSTESQLEAL 1166



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 88/437 (20%), Positives = 173/437 (39%), Gaps = 61/437 (13%)

Query: 163  EQCGDITAIRKSKKNFCHIRFAEEFMVDKAIYLSGYRMRLGSSTD-KKDSGRLHVDFAQA 221
            EQ  ++   R++++N    +  E    D+ I       + G   D KK    L     + 
Sbjct: 1508 EQIRELEKDRETQRNVLEHQLLELEKKDQMI-----ESQRGQVQDLKKQLVTLECLALEL 1562

Query: 222  RDDFYEWECKQRMRAREERHRRK-----------LEEDRLRPPSPPAIMHYSEHEAALLA 270
             ++ ++ EC+Q++    E  R             LEE      +  + +H  E  + +LA
Sbjct: 1563 EENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLA 1622

Query: 271  EKLKDDSKFSEAITVLLSWIERG------EVNRRSANQFYSMVQSANSHVRRLMNEKATH 324
             +L++  +  ++    +  ++R       ++ RR       M+Q     V      + T 
Sbjct: 1623 RELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQEL---MLQKERIQVLEDQRTRQTK 1679

Query: 325  --EQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWR---KH 379
              E+++E+ K + +     + TQ + +        R +     SKAQR +++  +   + 
Sbjct: 1680 ILEEDLEQIKLSLRERGRELTTQRQLM------QERAEEGKGPSKAQRGSLEHMKLILRD 1733

Query: 380  SEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQ 439
             E+    Q E +      E  E+ D           +V E++L       ++E   L+ Q
Sbjct: 1734 KEKEVECQQEHI-----HELQELKDQLEQQLQGLHRKVGETSLLLSQR--EQEIVVLQQQ 1786

Query: 440  LDAYRNEVELLKQE-KEQLFRTEENLT-KDQQLQFLQQTMQGMQQQLLTIQEE------- 490
            L   R + EL +Q  + QL   +  L  +DQ+L+ LQQ  Q  Q Q   ++E+       
Sbjct: 1787 LQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGA 1846

Query: 491  -------LNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELV-ETNGHSHEDSNEINVL 542
                   L  +  EL+  KE+    +  L V   +++  +E++ +    S E    +  L
Sbjct: 1847 LEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLAL 1906

Query: 543  TVALVNQDRENNIEKRS 559
                  Q +E+ +E R+
Sbjct: 1907 QQQCAEQAQEHEVETRA 1923



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 88/379 (23%), Positives = 143/379 (37%), Gaps = 80/379 (21%)

Query: 199  RMRLGSSTDKKDSGRLHVDFAQARDDFYEWECKQRMRAREERHRRKLEEDRLRPPSPPAI 258
            R   G    K   G L       RD   E EC+Q        H  +L+E + +       
Sbjct: 1709 RAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQE-------HIHELQELKDQLEQQLQG 1761

Query: 259  MHYSEHEAALLAEKLKDDSKFSEAITVLLSWI----ERGEVNRRSANQFYSMVQSA---- 310
            +H    E +LL       S+  + I VL   +    E+GE+  +S        Q A    
Sbjct: 1762 LHRKVGETSLLL------SQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQR 1815

Query: 311  NSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQR 370
            +  +  L  E+   + + E  KE   +AL G L Q    +   +   +    DH  +A+R
Sbjct: 1816 DQELEALQQEQQQAQGQEERVKEK-ADALQGALEQAHMTLKERHGELQ----DHKEQARR 1870

Query: 371  KNIDIWRKHSEELRNAQS-EQLMGIRREEEMEMSD-----DENCDSPTKKMRVD-----E 419
               ++    + E R  Q+ E+++G  R E  E         + C    ++  V+     +
Sbjct: 1871 LEEEL----AVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQD 1926

Query: 420  SALAAQAY---------ALKEENDSLRWQLDAYRNEVELLK----------QEKEQLFRT 460
            S L AQA          AL+ E+ S R Q +A R   E L+          Q KEQ    
Sbjct: 1927 SWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLE 1986

Query: 461  EENLTKD-------------------QQLQFLQQTMQG-MQQQLLTIQEELNNKKSELEQ 500
            +  L++                    +QL+   +  +G +Q Q L  QE++   +  L Q
Sbjct: 1987 QAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQ 2046

Query: 501  AKEEQSHTQALLKVLQEQL 519
              EE  H Q   ++L++ L
Sbjct: 2047 RDEELRHQQEREQLLEKSL 2065



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 51/255 (20%), Positives = 116/255 (45%), Gaps = 18/255 (7%)

Query: 326  QEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKA-WDHFSKAQRKNIDIWRKHSEELR 384
            Q++EE   + +   + + T+ + +    + +  +K+ W+   K      ++   H E + 
Sbjct: 1267 QKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWE--GKQNSLESELMELH-ETMA 1323

Query: 385  NAQSE------QLMGIRREEEMEMSDDENCDSPTKKMR---VDESALAAQAYALKEENDS 435
            + QS       Q M  + E E+  +  EN  +  + ++   V+  A A+ A  L+E+  +
Sbjct: 1324 SLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRT 1383

Query: 436  LRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKK 495
             R  L     EVE  ++  + L   E+   K  Q + LQ+ +  + Q L   +EE+   +
Sbjct: 1384 ARSALKLKNEEVESERERAQAL--QEQGELKVAQGKALQENLALLTQTLAEREEEVETLR 1441

Query: 496  SELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLT--VALVNQDREN 553
             ++++ ++++   +A L++L   LK   + V+      ++  +   +   + +  Q+RE 
Sbjct: 1442 GQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQ 1501

Query: 554  NIE-KRSQGLKSEKE 567
             +  +R Q  + EK+
Sbjct: 1502 KLTVQREQIRELEKD 1516



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 64/316 (20%), Positives = 132/316 (41%), Gaps = 34/316 (10%)

Query: 302  QFYSMVQSANSHVRR--LMNEKATHEQEM-EEAKENFKNALTGILTQFEQI-VAVFNAST 357
            + +  + S  S +RR  L   +A  E+E+ + AKEN       +  Q E +  AV  A  
Sbjct: 1317 ELHETMASLQSRLRRAELQRMEAQGERELLQAAKEN-------LTAQVEHLQAAVVEARA 1369

Query: 358  RQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRV 417
            +  A     +  R      +  +EE+ + + E+   ++ + E++++          K   
Sbjct: 1370 QASAAGILEEDLRTARSALKLKNEEVES-ERERAQALQEQGELKVAQG--------KALQ 1420

Query: 418  DESALAAQAYALKEEN-DSLRWQLDAYRNEVELLKQEKEQLF-----RTEENLTKDQQLQ 471
            +  AL  Q  A +EE  ++LR Q+     + E+ K   E L      R +E   + +Q+Q
Sbjct: 1421 ENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQ 1480

Query: 472  FLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQ---LKGTKELVET 528
             L++    ++   + +QE       + EQ +E +   +    VL+ Q   L+   +++E+
Sbjct: 1481 ELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIES 1540

Query: 529  NGHSHEDSNEINVLTVALVNQDRENN-----IEKRSQGLKSEKEALLIGIISTFLHVHPF 583
                 +D  +  V    L  +  EN+      +K  + L+ ++E   + +    L +   
Sbjct: 1541 QRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEER 1600

Query: 584  GANIEYLWSYMQQLDS 599
               ++   S +  L+S
Sbjct: 1601 SQELQAQSSQIHDLES 1616



 Score = 39.3 bits (90), Expect = 0.011
 Identities = 67/328 (20%), Positives = 125/328 (38%), Gaps = 52/328 (15%)

Query: 263 EHEAALLAEKLKDDSKFSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKA 322
           + E   + +KL +     EA T  L  + +       A +   ++  A      L+ EKA
Sbjct: 686 QEEKEEIQKKLSESRHQQEAATTQLEQLHQ------EAKRQEEVLARAVQEKEALVREKA 739

Query: 323 THE---QEMEEAKENFKNALTGILTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKH 379
             E   Q +E  +++    L G+ +  E + +    + +Q +    +K Q   +++  + 
Sbjct: 740 ALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQ---LEVQIQT 796

Query: 380 SEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQ-AYALKEENDSLRW 438
             + +     ++  ++ E + E S  E           +  A A Q A A +E   +L  
Sbjct: 797 VTQAKEVIQGEVRCLKLELDTERSQAEQ----------ERDAAARQLAQAEQEGKTALEQ 846

Query: 439 QLDAYRNEVELLKQ--EKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKS 496
           Q  A+  EV  L++  EKE+ +                      QQ+L    E L  +K 
Sbjct: 847 QKAAHEKEVNQLREKWEKERSWH---------------------QQELAKALESLEREKM 885

Query: 497 ELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEINVLTVALVNQ----DRE 552
           ELE   +EQ      ++  +E+ +   E          +   +++L   L  Q    D  
Sbjct: 886 ELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADAS 945

Query: 553 NNIEKRSQGLKSE--KEALLIGIISTFL 578
             +E+  Q +K +  KE    GI+ T L
Sbjct: 946 QQLERLRQDMKVQKLKEQETTGILQTQL 973



 Score = 36.6 bits (83), Expect = 0.073
 Identities = 55/273 (20%), Positives = 116/273 (42%), Gaps = 46/273 (16%)

Query: 326  QEMEEAKENFKNALTGILTQFEQIVAVFNASTRQ---------------KAWDHFSKAQR 370
            +E+E  +E  + ALT +    E+      A + Q               +  D   K+QR
Sbjct: 1577 KELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQR 1636

Query: 371  KNIDIWRKHSEELRN---AQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAY 427
            + I+  ++  E L      + ++LM   ++E +++ +D+     T++ ++ E  L     
Sbjct: 1637 EQIEELQRQKEHLTQDLERRDQELM--LQKERIQVLEDQR----TRQTKILEEDLEQIKL 1690

Query: 428  ALKEENDSLRWQLDAYRNEVELLK----------QEKEQLFRTEENLTKDQQ--LQFLQQ 475
            +L+E    L  Q    +   E  K          +  + + R +E   + QQ  +  LQ+
Sbjct: 1691 SLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQE 1750

Query: 476  TMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHED 535
                ++QQL  +  ++      L Q ++E       + VLQ+QL+  +E  E    S + 
Sbjct: 1751 LKDQLEQQLQGLHRKVGETSLLLSQREQE-------IVVLQQQLQEAREQGELKEQSLQ- 1802

Query: 536  SNEINVLTVALVNQDRE-NNIEKRSQGLKSEKE 567
             ++++    AL  +D+E   +++  Q  + ++E
Sbjct: 1803 -SQLDEAQRALAQRDQELEALQQEQQQAQGQEE 1834



 Score = 34.7 bits (78), Expect = 0.28
 Identities = 57/252 (22%), Positives = 109/252 (43%), Gaps = 41/252 (16%)

Query: 263  EHEAALLA--EKLKDDSKFSEAITVLL--SWIERGEVNRRSANQFYSMVQSANSHVRRLM 318
            E E ALLA  ++  + ++  E  T  L  SW++   V +    +  ++   A S   R  
Sbjct: 1898 EQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEAL--RAESQSSRHQ 1955

Query: 319  NEKATHEQE-MEEAKENFKNALTGI---LTQFEQIVAVFNASTRQKAWDHFSKAQRKNID 374
             E A    E ++EA      AL G    L +  ++     AST            + ++D
Sbjct: 1956 EEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTA---------TLQASLD 2006

Query: 375  IWRKHSEELRNAQSEQLMGIRREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEEND 434
              + HS +L  A         R +E E+ D +        +R  E     Q  AL + ++
Sbjct: 2007 ACQAHSRQLEEAL--------RIQEGEIQDQD--------LRYQEDVQQLQQ-ALAQRDE 2049

Query: 435  SLRWQLDAYRN-EVELLKQEKEQLFRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNN 493
             LR Q +  +  E  L ++ +E + + ++NL ++++    ++ ++G+ Q +  +Q  L  
Sbjct: 2050 ELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQERE----EEEIRGLHQSVRELQLTLAQ 2105

Query: 494  KKSELEQAKEEQ 505
            K+ E+ + +E Q
Sbjct: 2106 KEQEILELRETQ 2117



 Score = 30.8 bits (68), Expect = 4.0
 Identities = 62/322 (19%), Positives = 128/322 (39%), Gaps = 36/322 (11%)

Query: 229  ECKQRMRAREERHRRKLEE--DRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVL 286
            + K ++ A+++  R   +E  ++LR         Y+  +  L  EK        E    L
Sbjct: 1014 DLKSQLVAQDDSQRLVEQEVQEKLRETQ-----EYNRIQKELEREKASLTLSLMEKEQRL 1068

Query: 287  LSWIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQF 346
            L   E   + ++  +     +Q A    + L  +     QE++E + +F      +L + 
Sbjct: 1069 LVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEEL 1128

Query: 347  EQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQLMGIRREEEMEMSD-- 404
            E    +     R   W   +KA +  + + R    +L    +EQ  G + + + +++   
Sbjct: 1129 EAS-HITEQQLRASLWAQEAKAAQLQLRL-RSTESQLEALAAEQQPGNQAQAQAQLASLY 1186

Query: 405  -------DENCDSPTKKMRVDESALAAQAYALKEENDSLRWQ------LDAYRNEV--EL 449
                      C+S  +     +SA     + L+ + +  R        L A   E     
Sbjct: 1187 SALQQALGSVCESRPELSGGGDSA--PSVWGLEPDQNGARSLFKRGPLLTALSAEAVASA 1244

Query: 450  LKQEKEQLFRTEENLTKD---QQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQS 506
            L +  + L++T++  T+D    Q+Q L++ +   + +   +  EL + + +L Q +EE+S
Sbjct: 1245 LHKLHQDLWKTQQ--TRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKS 1302

Query: 507  HTQALLKVLQEQLKGTKELVET 528
              +     L+ +L    EL ET
Sbjct: 1303 KWEGKQNSLESEL---MELHET 1321


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 76/344 (22%), Positives = 143/344 (41%), Gaps = 43/344 (12%)

Query: 231  KQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWI 290
            +QR  A EE  RR+  E+R++  S  A    +    A L E  +  +K  EA  +     
Sbjct: 1971 RQRQLAAEEERRRREAEERVQK-SLAAEEEAARQRKAALEEVERLKAKVEEARRL----- 2024

Query: 291  ERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIV 350
             R    + SA Q     ++A    +RL  E+  H   +++ ++  +  L    +  +Q+ 
Sbjct: 2025 -RERAEQESARQLQLAQEAAQ---KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2080

Query: 351  AVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQ-SEQLMGIRREEEMEMSDDENCD 409
                A+ R        +A+   +   R+ ++  R  + +E+L     E+    +  +   
Sbjct: 2081 GEAEAARRAA-----EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2135

Query: 410  SPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQ 469
               +K    E+A  AQA     E  +LR Q  A   E+E  K+  EQ  R +  +  +Q+
Sbjct: 2136 EKLRKEAEQEAARRAQA-----EQAALR-QKQAADAEMEKHKKFAEQTLRQKAQV--EQE 2187

Query: 470  LQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALL---KVLQEQLKGTKELV 526
            L  L+  ++    Q   + EEL   K+E  +A  ++S  +  L   +V  E+L   K  +
Sbjct: 2188 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI 2247

Query: 527  ETNGHSHEDSNEINVLTVALVNQDRENN---IEKRSQGLKSEKE 567
            E                 AL+ +D++N    +++ ++ +K   E
Sbjct: 2248 EAENR-------------ALILRDKDNTQRFLQEEAEKMKQVAE 2278



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 76/344 (22%), Positives = 144/344 (41%), Gaps = 20/344 (5%)

Query: 229  ECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLS 288
            E  +R R   E   + L   R R     A    ++ EA  L  +++D+S+      V L+
Sbjct: 1462 EATERQRGGAEGELQAL---RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1518

Query: 289  WIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATH---EQEMEEAKENFKNALTGILTQ 345
               R +    +A +    +Q+      RL  E+A     + E+E A++  + AL      
Sbjct: 1519 --SRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQ-VQVALETAQRS 1573

Query: 346  FEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSE-QLMGIRREEEMEMSD 404
             E  +    AS  +K        Q +++ + +   E  R AQ + +    R E E E+  
Sbjct: 1574 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1633

Query: 405  DENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENL 464
             +   +   ++R+    +A Q    + E +    Q +    E     + +EQ  R  E  
Sbjct: 1634 WQLKANEALRLRLQAEEVAQQKSLAQAEAEK---QKEEAEREARRRGKAEEQAVRQRE-- 1688

Query: 465  TKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEE-QSHTQALLKVLQEQLKGTK 523
              +Q+L+  +Q  +G  QQ L  ++EL   ++E EQ +++ Q   + L ++ +E    T+
Sbjct: 1689 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1748

Query: 524  ELVETNGHSHEDSNEINVL--TVALVNQDRENNIEKRSQGLKSE 565
            +  E      +   E+ VL  + A   ++  +  EK  Q L++E
Sbjct: 1749 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1792



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 69/328 (21%), Positives = 137/328 (41%), Gaps = 50/328 (15%)

Query: 279  FSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRR-------LMNEKATHEQEMEEA 331
            + E+   L +W++     RR   Q  +M  + +  VR        L+ E   H +++EE 
Sbjct: 1212 YRESADPLGAWLQDA---RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEEC 1268

Query: 332  KENFKNALTGI-------LTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELR 384
            +   K  +  I       +T   Q+  V + + + K         ++ +D+ R H  EL 
Sbjct: 1269 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDL-RTHYSELT 1327

Query: 385  NAQSEQLMGI-----RREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQ 439
               S+ +  I     R EEE  +++ +  +   +   V E+AL  Q   L E +   + Q
Sbjct: 1328 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV-EAALEKQRQ-LAEAHAQAKAQ 1385

Query: 440  LDAYRNEVELLKQEKEQLFRTEEN-LTKDQQLQFLQQTMQGMQQQL-------------- 484
              A R   EL ++ +E++ R EE  +   QQ + +Q+ +Q ++Q                
Sbjct: 1386 --AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1443

Query: 485  ----LTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEIN 540
                L I+EE+   + +LE  + ++   +  L+ L+ +    +E       + E++  + 
Sbjct: 1444 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR---AEEAEAQKRQAQEEAERLR 1500

Query: 541  VLTVALVNQDRENNIEKRSQGLKSEKEA 568
                    + R+  +E  S+ +K+E EA
Sbjct: 1501 RQVQDESQRKRQAEVELASR-VKAEAEA 1527



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 74/354 (20%), Positives = 135/354 (38%), Gaps = 30/354 (8%)

Query: 231  KQRMRAREERHRRKLEED-RLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSW 289
            KQR+ A   R R   EE  RLR  +  A       E     ++ + +   +E +  +   
Sbjct: 1786 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI--- 1842

Query: 290  IERGEVNRRSANQFYSMVQ--SANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFE 347
               GE  R       ++ +  + N  +RRL  ++A   + +EE     K  +   L Q  
Sbjct: 1843 ---GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1899

Query: 348  QIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEEL--RNAQSEQLMGIRREEEMEMSDD 405
            +  A  +   RQK     +  QR+ ++      EE+    A  E+    + E E+E+   
Sbjct: 1900 K--ASDSELERQKGLVEDTLRQRRQVE------EEILALKASFEKAAAGKAELELELGRI 1951

Query: 406  ENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLD-----AYRNEVELLKQEKEQLFRT 460
             +    T + +      AA+   L  E +  R + +     +   E E  +Q K  L   
Sbjct: 1952 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2011

Query: 461  EENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQ---AKEEQSHTQALLKVLQE 517
            E    K ++ + L++  +    + L + +E   K+ + E+   A   Q   Q L + LQ+
Sbjct: 2012 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2071

Query: 518  QLKGTKEL---VETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEA 568
            +     +L    E    + E++ E  V       Q R    E       +E++A
Sbjct: 2072 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2125



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 98/425 (23%), Positives = 177/425 (41%), Gaps = 57/425 (13%)

Query: 233  RMRAREERHRRKL---EEDRLRPPSPPAIMHYSEHEAALLAEKLKDD--SKFS---EAIT 284
            R++  E  H++ L   E  RL+  +  A    S+ E  L + +++ +  SK     EA  
Sbjct: 2192 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2251

Query: 285  VLLSWIERGEVNRRSANQFYSMVQSANSHVR-RLMNEKATHEQEMEEAKENFKNALTGIL 343
              L   ++    R    +   M Q A    R  +  ++A   +++ E     + AL   +
Sbjct: 2252 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2311

Query: 344  TQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQL----MGIRR--E 397
             + E++ AV  A TR KA     + Q++      +  +E +   ++QL     G +R  E
Sbjct: 2312 LK-EKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE 2369

Query: 398  EEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQL 457
             E +   + + ++   K+RV E +  AQA A   E D+ R++  A        ++  E+L
Sbjct: 2370 AERQRQLEMSAEAERLKLRVAEMS-RAQARA---EEDAQRFRKQA--------EEIGEKL 2417

Query: 458  FRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLK---- 513
             RTE      Q+   L QT++  +QQ     E L    +ELE+ KE+      LL+    
Sbjct: 2418 HRTE---LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2474

Query: 514  ----VLQEQLKGTKELVETNGHSHEDS---------------NEINVLTVALVNQDRENN 554
                V QEQL    + ++ +  S +DS                ++    VA   Q RE  
Sbjct: 2475 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ 2534

Query: 555  IEKRSQGLKSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQLDSKISANEIEMLLMRLP 614
             +++ Q ++ E++ L+  +       H     +      +QQL+ +    E E+L     
Sbjct: 2535 -QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE-ELLAEENQ 2592

Query: 615  RMFKQ 619
            R+ +Q
Sbjct: 2593 RLREQ 2597


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 76/344 (22%), Positives = 143/344 (41%), Gaps = 43/344 (12%)

Query: 231  KQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWI 290
            +QR  A EE  RR+  E+R++  S  A    +    A L E  +  +K  EA  +     
Sbjct: 1975 RQRQLAAEEERRRREAEERVQK-SLAAEEEAARQRKAALEEVERLKAKVEEARRL----- 2028

Query: 291  ERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIV 350
             R    + SA Q     ++A    +RL  E+  H   +++ ++  +  L    +  +Q+ 
Sbjct: 2029 -RERAEQESARQLQLAQEAAQ---KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2084

Query: 351  AVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQ-SEQLMGIRREEEMEMSDDENCD 409
                A+ R        +A+   +   R+ ++  R  + +E+L     E+    +  +   
Sbjct: 2085 GEAEAARRAA-----EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2139

Query: 410  SPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQ 469
               +K    E+A  AQA     E  +LR Q  A   E+E  K+  EQ  R +  +  +Q+
Sbjct: 2140 EKLRKEAEQEAARRAQA-----EQAALR-QKQAADAEMEKHKKFAEQTLRQKAQV--EQE 2191

Query: 470  LQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALL---KVLQEQLKGTKELV 526
            L  L+  ++    Q   + EEL   K+E  +A  ++S  +  L   +V  E+L   K  +
Sbjct: 2192 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI 2251

Query: 527  ETNGHSHEDSNEINVLTVALVNQDRENN---IEKRSQGLKSEKE 567
            E                 AL+ +D++N    +++ ++ +K   E
Sbjct: 2252 EAENR-------------ALILRDKDNTQRFLQEEAEKMKQVAE 2282



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 76/344 (22%), Positives = 144/344 (41%), Gaps = 20/344 (5%)

Query: 229  ECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLS 288
            E  +R R   E   + L   R R     A    ++ EA  L  +++D+S+      V L+
Sbjct: 1466 EATERQRGGAEGELQAL---RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1522

Query: 289  WIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATH---EQEMEEAKENFKNALTGILTQ 345
               R +    +A +    +Q+      RL  E+A     + E+E A++  + AL      
Sbjct: 1523 --SRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQ-VQVALETAQRS 1577

Query: 346  FEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSE-QLMGIRREEEMEMSD 404
             E  +    AS  +K        Q +++ + +   E  R AQ + +    R E E E+  
Sbjct: 1578 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1637

Query: 405  DENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENL 464
             +   +   ++R+    +A Q    + E +    Q +    E     + +EQ  R  E  
Sbjct: 1638 WQLKANEALRLRLQAEEVAQQKSLAQAEAEK---QKEEAEREARRRGKAEEQAVRQRE-- 1692

Query: 465  TKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEE-QSHTQALLKVLQEQLKGTK 523
              +Q+L+  +Q  +G  QQ L  ++EL   ++E EQ +++ Q   + L ++ +E    T+
Sbjct: 1693 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1752

Query: 524  ELVETNGHSHEDSNEINVL--TVALVNQDRENNIEKRSQGLKSE 565
            +  E      +   E+ VL  + A   ++  +  EK  Q L++E
Sbjct: 1753 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1796



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 69/328 (21%), Positives = 137/328 (41%), Gaps = 50/328 (15%)

Query: 279  FSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRR-------LMNEKATHEQEMEEA 331
            + E+   L +W++     RR   Q  +M  + +  VR        L+ E   H +++EE 
Sbjct: 1216 YRESADPLGAWLQDA---RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEEC 1272

Query: 332  KENFKNALTGI-------LTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELR 384
            +   K  +  I       +T   Q+  V + + + K         ++ +D+ R H  EL 
Sbjct: 1273 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDL-RTHYSELT 1331

Query: 385  NAQSEQLMGI-----RREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQ 439
               S+ +  I     R EEE  +++ +  +   +   V E+AL  Q   L E +   + Q
Sbjct: 1332 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV-EAALEKQRQ-LAEAHAQAKAQ 1389

Query: 440  LDAYRNEVELLKQEKEQLFRTEEN-LTKDQQLQFLQQTMQGMQQQL-------------- 484
              A R   EL ++ +E++ R EE  +   QQ + +Q+ +Q ++Q                
Sbjct: 1390 --AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1447

Query: 485  ----LTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEIN 540
                L I+EE+   + +LE  + ++   +  L+ L+ +    +E       + E++  + 
Sbjct: 1448 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR---AEEAEAQKRQAQEEAERLR 1504

Query: 541  VLTVALVNQDRENNIEKRSQGLKSEKEA 568
                    + R+  +E  S+ +K+E EA
Sbjct: 1505 RQVQDESQRKRQAEVELASR-VKAEAEA 1531



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 74/354 (20%), Positives = 135/354 (38%), Gaps = 30/354 (8%)

Query: 231  KQRMRAREERHRRKLEED-RLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSW 289
            KQR+ A   R R   EE  RLR  +  A       E     ++ + +   +E +  +   
Sbjct: 1790 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI--- 1846

Query: 290  IERGEVNRRSANQFYSMVQ--SANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFE 347
               GE  R       ++ +  + N  +RRL  ++A   + +EE     K  +   L Q  
Sbjct: 1847 ---GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1903

Query: 348  QIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEEL--RNAQSEQLMGIRREEEMEMSDD 405
            +  A  +   RQK     +  QR+ ++      EE+    A  E+    + E E+E+   
Sbjct: 1904 K--ASDSELERQKGLVEDTLRQRRQVE------EEILALKASFEKAAAGKAELELELGRI 1955

Query: 406  ENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLD-----AYRNEVELLKQEKEQLFRT 460
             +    T + +      AA+   L  E +  R + +     +   E E  +Q K  L   
Sbjct: 1956 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2015

Query: 461  EENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQ---AKEEQSHTQALLKVLQE 517
            E    K ++ + L++  +    + L + +E   K+ + E+   A   Q   Q L + LQ+
Sbjct: 2016 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2075

Query: 518  QLKGTKEL---VETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEA 568
            +     +L    E    + E++ E  V       Q R    E       +E++A
Sbjct: 2076 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2129



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 98/425 (23%), Positives = 177/425 (41%), Gaps = 57/425 (13%)

Query: 233  RMRAREERHRRKL---EEDRLRPPSPPAIMHYSEHEAALLAEKLKDD--SKFS---EAIT 284
            R++  E  H++ L   E  RL+  +  A    S+ E  L + +++ +  SK     EA  
Sbjct: 2196 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2255

Query: 285  VLLSWIERGEVNRRSANQFYSMVQSANSHVR-RLMNEKATHEQEMEEAKENFKNALTGIL 343
              L   ++    R    +   M Q A    R  +  ++A   +++ E     + AL   +
Sbjct: 2256 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2315

Query: 344  TQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQL----MGIRR--E 397
             + E++ AV  A TR KA     + Q++      +  +E +   ++QL     G +R  E
Sbjct: 2316 LK-EKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE 2373

Query: 398  EEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQL 457
             E +   + + ++   K+RV E +  AQA A   E D+ R++  A        ++  E+L
Sbjct: 2374 AERQRQLEMSAEAERLKLRVAEMS-RAQARA---EEDAQRFRKQA--------EEIGEKL 2421

Query: 458  FRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLK---- 513
             RTE      Q+   L QT++  +QQ     E L    +ELE+ KE+      LL+    
Sbjct: 2422 HRTE---LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2478

Query: 514  ----VLQEQLKGTKELVETNGHSHEDS---------------NEINVLTVALVNQDRENN 554
                V QEQL    + ++ +  S +DS                ++    VA   Q RE  
Sbjct: 2479 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ 2538

Query: 555  IEKRSQGLKSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQLDSKISANEIEMLLMRLP 614
             +++ Q ++ E++ L+  +       H     +      +QQL+ +    E E+L     
Sbjct: 2539 -QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE-ELLAEENQ 2596

Query: 615  RMFKQ 619
            R+ +Q
Sbjct: 2597 RLREQ 2601


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 76/344 (22%), Positives = 143/344 (41%), Gaps = 43/344 (12%)

Query: 231  KQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWI 290
            +QR  A EE  RR+  E+R++  S  A    +    A L E  +  +K  EA  +     
Sbjct: 1971 RQRQLAAEEERRRREAEERVQK-SLAAEEEAARQRKAALEEVERLKAKVEEARRL----- 2024

Query: 291  ERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIV 350
             R    + SA Q     ++A    +RL  E+  H   +++ ++  +  L    +  +Q+ 
Sbjct: 2025 -RERAEQESARQLQLAQEAAQ---KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2080

Query: 351  AVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQ-SEQLMGIRREEEMEMSDDENCD 409
                A+ R        +A+   +   R+ ++  R  + +E+L     E+    +  +   
Sbjct: 2081 GEAEAARRAA-----EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2135

Query: 410  SPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQ 469
               +K    E+A  AQA     E  +LR Q  A   E+E  K+  EQ  R +  +  +Q+
Sbjct: 2136 EKLRKEAEQEAARRAQA-----EQAALR-QKQAADAEMEKHKKFAEQTLRQKAQV--EQE 2187

Query: 470  LQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALL---KVLQEQLKGTKELV 526
            L  L+  ++    Q   + EEL   K+E  +A  ++S  +  L   +V  E+L   K  +
Sbjct: 2188 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI 2247

Query: 527  ETNGHSHEDSNEINVLTVALVNQDRENN---IEKRSQGLKSEKE 567
            E                 AL+ +D++N    +++ ++ +K   E
Sbjct: 2248 EAENR-------------ALILRDKDNTQRFLQEEAEKMKQVAE 2278



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 76/344 (22%), Positives = 144/344 (41%), Gaps = 20/344 (5%)

Query: 229  ECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLS 288
            E  +R R   E   + L   R R     A    ++ EA  L  +++D+S+      V L+
Sbjct: 1462 EATERQRGGAEGELQAL---RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1518

Query: 289  WIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATH---EQEMEEAKENFKNALTGILTQ 345
               R +    +A +    +Q+      RL  E+A     + E+E A++  + AL      
Sbjct: 1519 --SRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQ-VQVALETAQRS 1573

Query: 346  FEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSE-QLMGIRREEEMEMSD 404
             E  +    AS  +K        Q +++ + +   E  R AQ + +    R E E E+  
Sbjct: 1574 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1633

Query: 405  DENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENL 464
             +   +   ++R+    +A Q    + E +    Q +    E     + +EQ  R  E  
Sbjct: 1634 WQLKANEALRLRLQAEEVAQQKSLAQAEAEK---QKEEAEREARRRGKAEEQAVRQRE-- 1688

Query: 465  TKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEE-QSHTQALLKVLQEQLKGTK 523
              +Q+L+  +Q  +G  QQ L  ++EL   ++E EQ +++ Q   + L ++ +E    T+
Sbjct: 1689 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1748

Query: 524  ELVETNGHSHEDSNEINVL--TVALVNQDRENNIEKRSQGLKSE 565
            +  E      +   E+ VL  + A   ++  +  EK  Q L++E
Sbjct: 1749 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1792



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 69/328 (21%), Positives = 137/328 (41%), Gaps = 50/328 (15%)

Query: 279  FSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRR-------LMNEKATHEQEMEEA 331
            + E+   L +W++     RR   Q  +M  + +  VR        L+ E   H +++EE 
Sbjct: 1212 YRESADPLGAWLQDA---RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEEC 1268

Query: 332  KENFKNALTGI-------LTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELR 384
            +   K  +  I       +T   Q+  V + + + K         ++ +D+ R H  EL 
Sbjct: 1269 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDL-RTHYSELT 1327

Query: 385  NAQSEQLMGI-----RREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQ 439
               S+ +  I     R EEE  +++ +  +   +   V E+AL  Q   L E +   + Q
Sbjct: 1328 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV-EAALEKQRQ-LAEAHAQAKAQ 1385

Query: 440  LDAYRNEVELLKQEKEQLFRTEEN-LTKDQQLQFLQQTMQGMQQQL-------------- 484
              A R   EL ++ +E++ R EE  +   QQ + +Q+ +Q ++Q                
Sbjct: 1386 --AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1443

Query: 485  ----LTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEIN 540
                L I+EE+   + +LE  + ++   +  L+ L+ +    +E       + E++  + 
Sbjct: 1444 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR---AEEAEAQKRQAQEEAERLR 1500

Query: 541  VLTVALVNQDRENNIEKRSQGLKSEKEA 568
                    + R+  +E  S+ +K+E EA
Sbjct: 1501 RQVQDESQRKRQAEVELASR-VKAEAEA 1527



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 74/354 (20%), Positives = 135/354 (38%), Gaps = 30/354 (8%)

Query: 231  KQRMRAREERHRRKLEED-RLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSW 289
            KQR+ A   R R   EE  RLR  +  A       E     ++ + +   +E +  +   
Sbjct: 1786 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI--- 1842

Query: 290  IERGEVNRRSANQFYSMVQ--SANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFE 347
               GE  R       ++ +  + N  +RRL  ++A   + +EE     K  +   L Q  
Sbjct: 1843 ---GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1899

Query: 348  QIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEEL--RNAQSEQLMGIRREEEMEMSDD 405
            +  A  +   RQK     +  QR+ ++      EE+    A  E+    + E E+E+   
Sbjct: 1900 K--ASDSELERQKGLVEDTLRQRRQVE------EEILALKASFEKAAAGKAELELELGRI 1951

Query: 406  ENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLD-----AYRNEVELLKQEKEQLFRT 460
             +    T + +      AA+   L  E +  R + +     +   E E  +Q K  L   
Sbjct: 1952 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2011

Query: 461  EENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQ---AKEEQSHTQALLKVLQE 517
            E    K ++ + L++  +    + L + +E   K+ + E+   A   Q   Q L + LQ+
Sbjct: 2012 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2071

Query: 518  QLKGTKEL---VETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEA 568
            +     +L    E    + E++ E  V       Q R    E       +E++A
Sbjct: 2072 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2125



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 98/425 (23%), Positives = 177/425 (41%), Gaps = 57/425 (13%)

Query: 233  RMRAREERHRRKL---EEDRLRPPSPPAIMHYSEHEAALLAEKLKDD--SKFS---EAIT 284
            R++  E  H++ L   E  RL+  +  A    S+ E  L + +++ +  SK     EA  
Sbjct: 2192 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2251

Query: 285  VLLSWIERGEVNRRSANQFYSMVQSANSHVR-RLMNEKATHEQEMEEAKENFKNALTGIL 343
              L   ++    R    +   M Q A    R  +  ++A   +++ E     + AL   +
Sbjct: 2252 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2311

Query: 344  TQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQL----MGIRR--E 397
             + E++ AV  A TR KA     + Q++      +  +E +   ++QL     G +R  E
Sbjct: 2312 LK-EKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE 2369

Query: 398  EEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQL 457
             E +   + + ++   K+RV E +  AQA A   E D+ R++  A        ++  E+L
Sbjct: 2370 AERQRQLEMSAEAERLKLRVAEMS-RAQARA---EEDAQRFRKQA--------EEIGEKL 2417

Query: 458  FRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLK---- 513
             RTE      Q+   L QT++  +QQ     E L    +ELE+ KE+      LL+    
Sbjct: 2418 HRTE---LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2474

Query: 514  ----VLQEQLKGTKELVETNGHSHEDS---------------NEINVLTVALVNQDRENN 554
                V QEQL    + ++ +  S +DS                ++    VA   Q RE  
Sbjct: 2475 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ 2534

Query: 555  IEKRSQGLKSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQLDSKISANEIEMLLMRLP 614
             +++ Q ++ E++ L+  +       H     +      +QQL+ +    E E+L     
Sbjct: 2535 -QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE-ELLAEENQ 2592

Query: 615  RMFKQ 619
            R+ +Q
Sbjct: 2593 RLREQ 2597


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 76/344 (22%), Positives = 143/344 (41%), Gaps = 43/344 (12%)

Query: 231  KQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWI 290
            +QR  A EE  RR+  E+R++  S  A    +    A L E  +  +K  EA  +     
Sbjct: 1939 RQRQLAAEEERRRREAEERVQK-SLAAEEEAARQRKAALEEVERLKAKVEEARRL----- 1992

Query: 291  ERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIV 350
             R    + SA Q     ++A    +RL  E+  H   +++ ++  +  L    +  +Q+ 
Sbjct: 1993 -RERAEQESARQLQLAQEAAQ---KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2048

Query: 351  AVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQ-SEQLMGIRREEEMEMSDDENCD 409
                A+ R        +A+   +   R+ ++  R  + +E+L     E+    +  +   
Sbjct: 2049 GEAEAARRAA-----EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2103

Query: 410  SPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQ 469
               +K    E+A  AQA     E  +LR Q  A   E+E  K+  EQ  R +  +  +Q+
Sbjct: 2104 EKLRKEAEQEAARRAQA-----EQAALR-QKQAADAEMEKHKKFAEQTLRQKAQV--EQE 2155

Query: 470  LQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALL---KVLQEQLKGTKELV 526
            L  L+  ++    Q   + EEL   K+E  +A  ++S  +  L   +V  E+L   K  +
Sbjct: 2156 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI 2215

Query: 527  ETNGHSHEDSNEINVLTVALVNQDRENN---IEKRSQGLKSEKE 567
            E                 AL+ +D++N    +++ ++ +K   E
Sbjct: 2216 EAENR-------------ALILRDKDNTQRFLQEEAEKMKQVAE 2246



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 76/344 (22%), Positives = 144/344 (41%), Gaps = 20/344 (5%)

Query: 229  ECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLS 288
            E  +R R   E   + L   R R     A    ++ EA  L  +++D+S+      V L+
Sbjct: 1430 EATERQRGGAEGELQAL---RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1486

Query: 289  WIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATH---EQEMEEAKENFKNALTGILTQ 345
               R +    +A +    +Q+      RL  E+A     + E+E A++  + AL      
Sbjct: 1487 --SRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQ-VQVALETAQRS 1541

Query: 346  FEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSE-QLMGIRREEEMEMSD 404
             E  +    AS  +K        Q +++ + +   E  R AQ + +    R E E E+  
Sbjct: 1542 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1601

Query: 405  DENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENL 464
             +   +   ++R+    +A Q    + E +    Q +    E     + +EQ  R  E  
Sbjct: 1602 WQLKANEALRLRLQAEEVAQQKSLAQAEAEK---QKEEAEREARRRGKAEEQAVRQRE-- 1656

Query: 465  TKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEE-QSHTQALLKVLQEQLKGTK 523
              +Q+L+  +Q  +G  QQ L  ++EL   ++E EQ +++ Q   + L ++ +E    T+
Sbjct: 1657 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1716

Query: 524  ELVETNGHSHEDSNEINVL--TVALVNQDRENNIEKRSQGLKSE 565
            +  E      +   E+ VL  + A   ++  +  EK  Q L++E
Sbjct: 1717 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1760



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 69/328 (21%), Positives = 137/328 (41%), Gaps = 50/328 (15%)

Query: 279  FSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRR-------LMNEKATHEQEMEEA 331
            + E+   L +W++     RR   Q  +M  + +  VR        L+ E   H +++EE 
Sbjct: 1180 YRESADPLGAWLQDA---RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEEC 1236

Query: 332  KENFKNALTGI-------LTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELR 384
            +   K  +  I       +T   Q+  V + + + K         ++ +D+ R H  EL 
Sbjct: 1237 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDL-RTHYSELT 1295

Query: 385  NAQSEQLMGI-----RREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQ 439
               S+ +  I     R EEE  +++ +  +   +   V E+AL  Q   L E +   + Q
Sbjct: 1296 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV-EAALEKQRQ-LAEAHAQAKAQ 1353

Query: 440  LDAYRNEVELLKQEKEQLFRTEEN-LTKDQQLQFLQQTMQGMQQQL-------------- 484
              A R   EL ++ +E++ R EE  +   QQ + +Q+ +Q ++Q                
Sbjct: 1354 --AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1411

Query: 485  ----LTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEIN 540
                L I+EE+   + +LE  + ++   +  L+ L+ +    +E       + E++  + 
Sbjct: 1412 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR---AEEAEAQKRQAQEEAERLR 1468

Query: 541  VLTVALVNQDRENNIEKRSQGLKSEKEA 568
                    + R+  +E  S+ +K+E EA
Sbjct: 1469 RQVQDESQRKRQAEVELASR-VKAEAEA 1495



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 74/354 (20%), Positives = 135/354 (38%), Gaps = 30/354 (8%)

Query: 231  KQRMRAREERHRRKLEED-RLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSW 289
            KQR+ A   R R   EE  RLR  +  A       E     ++ + +   +E +  +   
Sbjct: 1754 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI--- 1810

Query: 290  IERGEVNRRSANQFYSMVQ--SANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFE 347
               GE  R       ++ +  + N  +RRL  ++A   + +EE     K  +   L Q  
Sbjct: 1811 ---GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1867

Query: 348  QIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEEL--RNAQSEQLMGIRREEEMEMSDD 405
            +  A  +   RQK     +  QR+ ++      EE+    A  E+    + E E+E+   
Sbjct: 1868 K--ASDSELERQKGLVEDTLRQRRQVE------EEILALKASFEKAAAGKAELELELGRI 1919

Query: 406  ENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLD-----AYRNEVELLKQEKEQLFRT 460
             +    T + +      AA+   L  E +  R + +     +   E E  +Q K  L   
Sbjct: 1920 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1979

Query: 461  EENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQ---AKEEQSHTQALLKVLQE 517
            E    K ++ + L++  +    + L + +E   K+ + E+   A   Q   Q L + LQ+
Sbjct: 1980 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2039

Query: 518  QLKGTKEL---VETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEA 568
            +     +L    E    + E++ E  V       Q R    E       +E++A
Sbjct: 2040 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2093



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 98/425 (23%), Positives = 177/425 (41%), Gaps = 57/425 (13%)

Query: 233  RMRAREERHRRKL---EEDRLRPPSPPAIMHYSEHEAALLAEKLKDD--SKFS---EAIT 284
            R++  E  H++ L   E  RL+  +  A    S+ E  L + +++ +  SK     EA  
Sbjct: 2160 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2219

Query: 285  VLLSWIERGEVNRRSANQFYSMVQSANSHVR-RLMNEKATHEQEMEEAKENFKNALTGIL 343
              L   ++    R    +   M Q A    R  +  ++A   +++ E     + AL   +
Sbjct: 2220 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2279

Query: 344  TQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQL----MGIRR--E 397
             + E++ AV  A TR KA     + Q++      +  +E +   ++QL     G +R  E
Sbjct: 2280 LK-EKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE 2337

Query: 398  EEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQL 457
             E +   + + ++   K+RV E +  AQA A   E D+ R++  A        ++  E+L
Sbjct: 2338 AERQRQLEMSAEAERLKLRVAEMS-RAQARA---EEDAQRFRKQA--------EEIGEKL 2385

Query: 458  FRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLK---- 513
             RTE      Q+   L QT++  +QQ     E L    +ELE+ KE+      LL+    
Sbjct: 2386 HRTE---LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2442

Query: 514  ----VLQEQLKGTKELVETNGHSHEDS---------------NEINVLTVALVNQDRENN 554
                V QEQL    + ++ +  S +DS                ++    VA   Q RE  
Sbjct: 2443 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ 2502

Query: 555  IEKRSQGLKSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQLDSKISANEIEMLLMRLP 614
             +++ Q ++ E++ L+  +       H     +      +QQL+ +    E E+L     
Sbjct: 2503 -QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE-ELLAEENQ 2560

Query: 615  RMFKQ 619
            R+ +Q
Sbjct: 2561 RLREQ 2565


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 76/344 (22%), Positives = 143/344 (41%), Gaps = 43/344 (12%)

Query: 231  KQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWI 290
            +QR  A EE  RR+  E+R++  S  A    +    A L E  +  +K  EA  +     
Sbjct: 2108 RQRQLAAEEERRRREAEERVQK-SLAAEEEAARQRKAALEEVERLKAKVEEARRL----- 2161

Query: 291  ERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIV 350
             R    + SA Q     ++A    +RL  E+  H   +++ ++  +  L    +  +Q+ 
Sbjct: 2162 -RERAEQESARQLQLAQEAAQ---KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2217

Query: 351  AVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQ-SEQLMGIRREEEMEMSDDENCD 409
                A+ R        +A+   +   R+ ++  R  + +E+L     E+    +  +   
Sbjct: 2218 GEAEAARRAA-----EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2272

Query: 410  SPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQ 469
               +K    E+A  AQA     E  +LR Q  A   E+E  K+  EQ  R +  +  +Q+
Sbjct: 2273 EKLRKEAEQEAARRAQA-----EQAALR-QKQAADAEMEKHKKFAEQTLRQKAQV--EQE 2324

Query: 470  LQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALL---KVLQEQLKGTKELV 526
            L  L+  ++    Q   + EEL   K+E  +A  ++S  +  L   +V  E+L   K  +
Sbjct: 2325 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI 2384

Query: 527  ETNGHSHEDSNEINVLTVALVNQDRENN---IEKRSQGLKSEKE 567
            E                 AL+ +D++N    +++ ++ +K   E
Sbjct: 2385 EAENR-------------ALILRDKDNTQRFLQEEAEKMKQVAE 2415



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 76/344 (22%), Positives = 144/344 (41%), Gaps = 20/344 (5%)

Query: 229  ECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLS 288
            E  +R R   E   + L   R R     A    ++ EA  L  +++D+S+      V L+
Sbjct: 1599 EATERQRGGAEGELQAL---RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1655

Query: 289  WIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATH---EQEMEEAKENFKNALTGILTQ 345
               R +    +A +    +Q+      RL  E+A     + E+E A++  + AL      
Sbjct: 1656 --SRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQ-VQVALETAQRS 1710

Query: 346  FEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSE-QLMGIRREEEMEMSD 404
             E  +    AS  +K        Q +++ + +   E  R AQ + +    R E E E+  
Sbjct: 1711 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1770

Query: 405  DENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENL 464
             +   +   ++R+    +A Q    + E +    Q +    E     + +EQ  R  E  
Sbjct: 1771 WQLKANEALRLRLQAEEVAQQKSLAQAEAEK---QKEEAEREARRRGKAEEQAVRQRE-- 1825

Query: 465  TKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEE-QSHTQALLKVLQEQLKGTK 523
              +Q+L+  +Q  +G  QQ L  ++EL   ++E EQ +++ Q   + L ++ +E    T+
Sbjct: 1826 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1885

Query: 524  ELVETNGHSHEDSNEINVL--TVALVNQDRENNIEKRSQGLKSE 565
            +  E      +   E+ VL  + A   ++  +  EK  Q L++E
Sbjct: 1886 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1929



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 69/328 (21%), Positives = 137/328 (41%), Gaps = 50/328 (15%)

Query: 279  FSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRR-------LMNEKATHEQEMEEA 331
            + E+   L +W++     RR   Q  +M  + +  VR        L+ E   H +++EE 
Sbjct: 1349 YRESADPLGAWLQDA---RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEEC 1405

Query: 332  KENFKNALTGI-------LTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELR 384
            +   K  +  I       +T   Q+  V + + + K         ++ +D+ R H  EL 
Sbjct: 1406 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDL-RTHYSELT 1464

Query: 385  NAQSEQLMGI-----RREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQ 439
               S+ +  I     R EEE  +++ +  +   +   V E+AL  Q   L E +   + Q
Sbjct: 1465 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV-EAALEKQRQ-LAEAHAQAKAQ 1522

Query: 440  LDAYRNEVELLKQEKEQLFRTEEN-LTKDQQLQFLQQTMQGMQQQL-------------- 484
              A R   EL ++ +E++ R EE  +   QQ + +Q+ +Q ++Q                
Sbjct: 1523 --AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1580

Query: 485  ----LTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEIN 540
                L I+EE+   + +LE  + ++   +  L+ L+ +    +E       + E++  + 
Sbjct: 1581 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR---AEEAEAQKRQAQEEAERLR 1637

Query: 541  VLTVALVNQDRENNIEKRSQGLKSEKEA 568
                    + R+  +E  S+ +K+E EA
Sbjct: 1638 RQVQDESQRKRQAEVELASR-VKAEAEA 1664



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 74/354 (20%), Positives = 135/354 (38%), Gaps = 30/354 (8%)

Query: 231  KQRMRAREERHRRKLEED-RLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSW 289
            KQR+ A   R R   EE  RLR  +  A       E     ++ + +   +E +  +   
Sbjct: 1923 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI--- 1979

Query: 290  IERGEVNRRSANQFYSMVQ--SANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFE 347
               GE  R       ++ +  + N  +RRL  ++A   + +EE     K  +   L Q  
Sbjct: 1980 ---GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 2036

Query: 348  QIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEEL--RNAQSEQLMGIRREEEMEMSDD 405
            +  A  +   RQK     +  QR+ ++      EE+    A  E+    + E E+E+   
Sbjct: 2037 K--ASDSELERQKGLVEDTLRQRRQVE------EEILALKASFEKAAAGKAELELELGRI 2088

Query: 406  ENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLD-----AYRNEVELLKQEKEQLFRT 460
             +    T + +      AA+   L  E +  R + +     +   E E  +Q K  L   
Sbjct: 2089 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2148

Query: 461  EENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQ---AKEEQSHTQALLKVLQE 517
            E    K ++ + L++  +    + L + +E   K+ + E+   A   Q   Q L + LQ+
Sbjct: 2149 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2208

Query: 518  QLKGTKEL---VETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEA 568
            +     +L    E    + E++ E  V       Q R    E       +E++A
Sbjct: 2209 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2262



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 98/425 (23%), Positives = 177/425 (41%), Gaps = 57/425 (13%)

Query: 233  RMRAREERHRRKL---EEDRLRPPSPPAIMHYSEHEAALLAEKLKDD--SKFS---EAIT 284
            R++  E  H++ L   E  RL+  +  A    S+ E  L + +++ +  SK     EA  
Sbjct: 2329 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2388

Query: 285  VLLSWIERGEVNRRSANQFYSMVQSANSHVR-RLMNEKATHEQEMEEAKENFKNALTGIL 343
              L   ++    R    +   M Q A    R  +  ++A   +++ E     + AL   +
Sbjct: 2389 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2448

Query: 344  TQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQL----MGIRR--E 397
             + E++ AV  A TR KA     + Q++      +  +E +   ++QL     G +R  E
Sbjct: 2449 LK-EKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE 2506

Query: 398  EEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQL 457
             E +   + + ++   K+RV E +  AQA A   E D+ R++  A        ++  E+L
Sbjct: 2507 AERQRQLEMSAEAERLKLRVAEMS-RAQARA---EEDAQRFRKQA--------EEIGEKL 2554

Query: 458  FRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLK---- 513
             RTE      Q+   L QT++  +QQ     E L    +ELE+ KE+      LL+    
Sbjct: 2555 HRTE---LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2611

Query: 514  ----VLQEQLKGTKELVETNGHSHEDS---------------NEINVLTVALVNQDRENN 554
                V QEQL    + ++ +  S +DS                ++    VA   Q RE  
Sbjct: 2612 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ 2671

Query: 555  IEKRSQGLKSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQLDSKISANEIEMLLMRLP 614
             +++ Q ++ E++ L+  +       H     +      +QQL+ +    E E+L     
Sbjct: 2672 -QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE-ELLAEENQ 2729

Query: 615  RMFKQ 619
            R+ +Q
Sbjct: 2730 RLREQ 2734


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 76/344 (22%), Positives = 143/344 (41%), Gaps = 43/344 (12%)

Query: 231  KQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWI 290
            +QR  A EE  RR+  E+R++  S  A    +    A L E  +  +K  EA  +     
Sbjct: 1949 RQRQLAAEEERRRREAEERVQK-SLAAEEEAARQRKAALEEVERLKAKVEEARRL----- 2002

Query: 291  ERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIV 350
             R    + SA Q     ++A    +RL  E+  H   +++ ++  +  L    +  +Q+ 
Sbjct: 2003 -RERAEQESARQLQLAQEAAQ---KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2058

Query: 351  AVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQ-SEQLMGIRREEEMEMSDDENCD 409
                A+ R        +A+   +   R+ ++  R  + +E+L     E+    +  +   
Sbjct: 2059 GEAEAARRAA-----EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2113

Query: 410  SPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQ 469
               +K    E+A  AQA     E  +LR Q  A   E+E  K+  EQ  R +  +  +Q+
Sbjct: 2114 EKLRKEAEQEAARRAQA-----EQAALR-QKQAADAEMEKHKKFAEQTLRQKAQV--EQE 2165

Query: 470  LQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALL---KVLQEQLKGTKELV 526
            L  L+  ++    Q   + EEL   K+E  +A  ++S  +  L   +V  E+L   K  +
Sbjct: 2166 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI 2225

Query: 527  ETNGHSHEDSNEINVLTVALVNQDRENN---IEKRSQGLKSEKE 567
            E                 AL+ +D++N    +++ ++ +K   E
Sbjct: 2226 EAENR-------------ALILRDKDNTQRFLQEEAEKMKQVAE 2256



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 76/344 (22%), Positives = 144/344 (41%), Gaps = 20/344 (5%)

Query: 229  ECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLS 288
            E  +R R   E   + L   R R     A    ++ EA  L  +++D+S+      V L+
Sbjct: 1440 EATERQRGGAEGELQAL---RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1496

Query: 289  WIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATH---EQEMEEAKENFKNALTGILTQ 345
               R +    +A +    +Q+      RL  E+A     + E+E A++  + AL      
Sbjct: 1497 --SRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQ-VQVALETAQRS 1551

Query: 346  FEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSE-QLMGIRREEEMEMSD 404
             E  +    AS  +K        Q +++ + +   E  R AQ + +    R E E E+  
Sbjct: 1552 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1611

Query: 405  DENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENL 464
             +   +   ++R+    +A Q    + E +    Q +    E     + +EQ  R  E  
Sbjct: 1612 WQLKANEALRLRLQAEEVAQQKSLAQAEAEK---QKEEAEREARRRGKAEEQAVRQRE-- 1666

Query: 465  TKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEE-QSHTQALLKVLQEQLKGTK 523
              +Q+L+  +Q  +G  QQ L  ++EL   ++E EQ +++ Q   + L ++ +E    T+
Sbjct: 1667 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1726

Query: 524  ELVETNGHSHEDSNEINVL--TVALVNQDRENNIEKRSQGLKSE 565
            +  E      +   E+ VL  + A   ++  +  EK  Q L++E
Sbjct: 1727 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1770



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 69/328 (21%), Positives = 137/328 (41%), Gaps = 50/328 (15%)

Query: 279  FSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRR-------LMNEKATHEQEMEEA 331
            + E+   L +W++     RR   Q  +M  + +  VR        L+ E   H +++EE 
Sbjct: 1190 YRESADPLGAWLQDA---RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEEC 1246

Query: 332  KENFKNALTGI-------LTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELR 384
            +   K  +  I       +T   Q+  V + + + K         ++ +D+ R H  EL 
Sbjct: 1247 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDL-RTHYSELT 1305

Query: 385  NAQSEQLMGI-----RREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQ 439
               S+ +  I     R EEE  +++ +  +   +   V E+AL  Q   L E +   + Q
Sbjct: 1306 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV-EAALEKQRQ-LAEAHAQAKAQ 1363

Query: 440  LDAYRNEVELLKQEKEQLFRTEEN-LTKDQQLQFLQQTMQGMQQQL-------------- 484
              A R   EL ++ +E++ R EE  +   QQ + +Q+ +Q ++Q                
Sbjct: 1364 --AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1421

Query: 485  ----LTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEIN 540
                L I+EE+   + +LE  + ++   +  L+ L+ +    +E       + E++  + 
Sbjct: 1422 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR---AEEAEAQKRQAQEEAERLR 1478

Query: 541  VLTVALVNQDRENNIEKRSQGLKSEKEA 568
                    + R+  +E  S+ +K+E EA
Sbjct: 1479 RQVQDESQRKRQAEVELASR-VKAEAEA 1505



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 74/354 (20%), Positives = 135/354 (38%), Gaps = 30/354 (8%)

Query: 231  KQRMRAREERHRRKLEED-RLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSW 289
            KQR+ A   R R   EE  RLR  +  A       E     ++ + +   +E +  +   
Sbjct: 1764 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI--- 1820

Query: 290  IERGEVNRRSANQFYSMVQ--SANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFE 347
               GE  R       ++ +  + N  +RRL  ++A   + +EE     K  +   L Q  
Sbjct: 1821 ---GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1877

Query: 348  QIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEEL--RNAQSEQLMGIRREEEMEMSDD 405
            +  A  +   RQK     +  QR+ ++      EE+    A  E+    + E E+E+   
Sbjct: 1878 K--ASDSELERQKGLVEDTLRQRRQVE------EEILALKASFEKAAAGKAELELELGRI 1929

Query: 406  ENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLD-----AYRNEVELLKQEKEQLFRT 460
             +    T + +      AA+   L  E +  R + +     +   E E  +Q K  L   
Sbjct: 1930 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1989

Query: 461  EENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQ---AKEEQSHTQALLKVLQE 517
            E    K ++ + L++  +    + L + +E   K+ + E+   A   Q   Q L + LQ+
Sbjct: 1990 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2049

Query: 518  QLKGTKEL---VETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEA 568
            +     +L    E    + E++ E  V       Q R    E       +E++A
Sbjct: 2050 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2103



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 98/425 (23%), Positives = 177/425 (41%), Gaps = 57/425 (13%)

Query: 233  RMRAREERHRRKL---EEDRLRPPSPPAIMHYSEHEAALLAEKLKDD--SKFS---EAIT 284
            R++  E  H++ L   E  RL+  +  A    S+ E  L + +++ +  SK     EA  
Sbjct: 2170 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2229

Query: 285  VLLSWIERGEVNRRSANQFYSMVQSANSHVR-RLMNEKATHEQEMEEAKENFKNALTGIL 343
              L   ++    R    +   M Q A    R  +  ++A   +++ E     + AL   +
Sbjct: 2230 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2289

Query: 344  TQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQL----MGIRR--E 397
             + E++ AV  A TR KA     + Q++      +  +E +   ++QL     G +R  E
Sbjct: 2290 LK-EKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE 2347

Query: 398  EEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQL 457
             E +   + + ++   K+RV E +  AQA A   E D+ R++  A        ++  E+L
Sbjct: 2348 AERQRQLEMSAEAERLKLRVAEMS-RAQARA---EEDAQRFRKQA--------EEIGEKL 2395

Query: 458  FRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLK---- 513
             RTE      Q+   L QT++  +QQ     E L    +ELE+ KE+      LL+    
Sbjct: 2396 HRTE---LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2452

Query: 514  ----VLQEQLKGTKELVETNGHSHEDS---------------NEINVLTVALVNQDRENN 554
                V QEQL    + ++ +  S +DS                ++    VA   Q RE  
Sbjct: 2453 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ 2512

Query: 555  IEKRSQGLKSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQLDSKISANEIEMLLMRLP 614
             +++ Q ++ E++ L+  +       H     +      +QQL+ +    E E+L     
Sbjct: 2513 -QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE-ELLAEENQ 2570

Query: 615  RMFKQ 619
            R+ +Q
Sbjct: 2571 RLREQ 2575


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 76/344 (22%), Positives = 143/344 (41%), Gaps = 43/344 (12%)

Query: 231  KQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWI 290
            +QR  A EE  RR+  E+R++  S  A    +    A L E  +  +K  EA  +     
Sbjct: 1957 RQRQLAAEEERRRREAEERVQK-SLAAEEEAARQRKAALEEVERLKAKVEEARRL----- 2010

Query: 291  ERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIV 350
             R    + SA Q     ++A    +RL  E+  H   +++ ++  +  L    +  +Q+ 
Sbjct: 2011 -RERAEQESARQLQLAQEAAQ---KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2066

Query: 351  AVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQ-SEQLMGIRREEEMEMSDDENCD 409
                A+ R        +A+   +   R+ ++  R  + +E+L     E+    +  +   
Sbjct: 2067 GEAEAARRAA-----EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2121

Query: 410  SPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQ 469
               +K    E+A  AQA     E  +LR Q  A   E+E  K+  EQ  R +  +  +Q+
Sbjct: 2122 EKLRKEAEQEAARRAQA-----EQAALR-QKQAADAEMEKHKKFAEQTLRQKAQV--EQE 2173

Query: 470  LQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALL---KVLQEQLKGTKELV 526
            L  L+  ++    Q   + EEL   K+E  +A  ++S  +  L   +V  E+L   K  +
Sbjct: 2174 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI 2233

Query: 527  ETNGHSHEDSNEINVLTVALVNQDRENN---IEKRSQGLKSEKE 567
            E                 AL+ +D++N    +++ ++ +K   E
Sbjct: 2234 EAENR-------------ALILRDKDNTQRFLQEEAEKMKQVAE 2264



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 76/344 (22%), Positives = 144/344 (41%), Gaps = 20/344 (5%)

Query: 229  ECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLS 288
            E  +R R   E   + L   R R     A    ++ EA  L  +++D+S+      V L+
Sbjct: 1448 EATERQRGGAEGELQAL---RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1504

Query: 289  WIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATH---EQEMEEAKENFKNALTGILTQ 345
               R +    +A +    +Q+      RL  E+A     + E+E A++  + AL      
Sbjct: 1505 --SRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQ-VQVALETAQRS 1559

Query: 346  FEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSE-QLMGIRREEEMEMSD 404
             E  +    AS  +K        Q +++ + +   E  R AQ + +    R E E E+  
Sbjct: 1560 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1619

Query: 405  DENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENL 464
             +   +   ++R+    +A Q    + E +    Q +    E     + +EQ  R  E  
Sbjct: 1620 WQLKANEALRLRLQAEEVAQQKSLAQAEAEK---QKEEAEREARRRGKAEEQAVRQRE-- 1674

Query: 465  TKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEE-QSHTQALLKVLQEQLKGTK 523
              +Q+L+  +Q  +G  QQ L  ++EL   ++E EQ +++ Q   + L ++ +E    T+
Sbjct: 1675 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1734

Query: 524  ELVETNGHSHEDSNEINVL--TVALVNQDRENNIEKRSQGLKSE 565
            +  E      +   E+ VL  + A   ++  +  EK  Q L++E
Sbjct: 1735 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1778



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 69/328 (21%), Positives = 137/328 (41%), Gaps = 50/328 (15%)

Query: 279  FSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRR-------LMNEKATHEQEMEEA 331
            + E+   L +W++     RR   Q  +M  + +  VR        L+ E   H +++EE 
Sbjct: 1198 YRESADPLGAWLQDA---RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEEC 1254

Query: 332  KENFKNALTGI-------LTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELR 384
            +   K  +  I       +T   Q+  V + + + K         ++ +D+ R H  EL 
Sbjct: 1255 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDL-RTHYSELT 1313

Query: 385  NAQSEQLMGI-----RREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQ 439
               S+ +  I     R EEE  +++ +  +   +   V E+AL  Q   L E +   + Q
Sbjct: 1314 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV-EAALEKQRQ-LAEAHAQAKAQ 1371

Query: 440  LDAYRNEVELLKQEKEQLFRTEEN-LTKDQQLQFLQQTMQGMQQQL-------------- 484
              A R   EL ++ +E++ R EE  +   QQ + +Q+ +Q ++Q                
Sbjct: 1372 --AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1429

Query: 485  ----LTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEIN 540
                L I+EE+   + +LE  + ++   +  L+ L+ +    +E       + E++  + 
Sbjct: 1430 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR---AEEAEAQKRQAQEEAERLR 1486

Query: 541  VLTVALVNQDRENNIEKRSQGLKSEKEA 568
                    + R+  +E  S+ +K+E EA
Sbjct: 1487 RQVQDESQRKRQAEVELASR-VKAEAEA 1513



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 74/354 (20%), Positives = 135/354 (38%), Gaps = 30/354 (8%)

Query: 231  KQRMRAREERHRRKLEED-RLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSW 289
            KQR+ A   R R   EE  RLR  +  A       E     ++ + +   +E +  +   
Sbjct: 1772 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI--- 1828

Query: 290  IERGEVNRRSANQFYSMVQ--SANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFE 347
               GE  R       ++ +  + N  +RRL  ++A   + +EE     K  +   L Q  
Sbjct: 1829 ---GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1885

Query: 348  QIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEEL--RNAQSEQLMGIRREEEMEMSDD 405
            +  A  +   RQK     +  QR+ ++      EE+    A  E+    + E E+E+   
Sbjct: 1886 K--ASDSELERQKGLVEDTLRQRRQVE------EEILALKASFEKAAAGKAELELELGRI 1937

Query: 406  ENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLD-----AYRNEVELLKQEKEQLFRT 460
             +    T + +      AA+   L  E +  R + +     +   E E  +Q K  L   
Sbjct: 1938 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1997

Query: 461  EENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQ---AKEEQSHTQALLKVLQE 517
            E    K ++ + L++  +    + L + +E   K+ + E+   A   Q   Q L + LQ+
Sbjct: 1998 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2057

Query: 518  QLKGTKEL---VETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEA 568
            +     +L    E    + E++ E  V       Q R    E       +E++A
Sbjct: 2058 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2111



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 98/425 (23%), Positives = 177/425 (41%), Gaps = 57/425 (13%)

Query: 233  RMRAREERHRRKL---EEDRLRPPSPPAIMHYSEHEAALLAEKLKDD--SKFS---EAIT 284
            R++  E  H++ L   E  RL+  +  A    S+ E  L + +++ +  SK     EA  
Sbjct: 2178 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2237

Query: 285  VLLSWIERGEVNRRSANQFYSMVQSANSHVR-RLMNEKATHEQEMEEAKENFKNALTGIL 343
              L   ++    R    +   M Q A    R  +  ++A   +++ E     + AL   +
Sbjct: 2238 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2297

Query: 344  TQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQL----MGIRR--E 397
             + E++ AV  A TR KA     + Q++      +  +E +   ++QL     G +R  E
Sbjct: 2298 LK-EKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE 2355

Query: 398  EEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQL 457
             E +   + + ++   K+RV E +  AQA A   E D+ R++  A        ++  E+L
Sbjct: 2356 AERQRQLEMSAEAERLKLRVAEMS-RAQARA---EEDAQRFRKQA--------EEIGEKL 2403

Query: 458  FRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLK---- 513
             RTE      Q+   L QT++  +QQ     E L    +ELE+ KE+      LL+    
Sbjct: 2404 HRTE---LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2460

Query: 514  ----VLQEQLKGTKELVETNGHSHEDS---------------NEINVLTVALVNQDRENN 554
                V QEQL    + ++ +  S +DS                ++    VA   Q RE  
Sbjct: 2461 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ 2520

Query: 555  IEKRSQGLKSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQLDSKISANEIEMLLMRLP 614
             +++ Q ++ E++ L+  +       H     +      +QQL+ +    E E+L     
Sbjct: 2521 -QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE-ELLAEENQ 2578

Query: 615  RMFKQ 619
            R+ +Q
Sbjct: 2579 RLREQ 2583


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 76/344 (22%), Positives = 143/344 (41%), Gaps = 43/344 (12%)

Query: 231  KQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSWI 290
            +QR  A EE  RR+  E+R++  S  A    +    A L E  +  +K  EA  +     
Sbjct: 1998 RQRQLAAEEERRRREAEERVQK-SLAAEEEAARQRKAALEEVERLKAKVEEARRL----- 2051

Query: 291  ERGEVNRRSANQFYSMVQSANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFEQIV 350
             R    + SA Q     ++A    +RL  E+  H   +++ ++  +  L    +  +Q+ 
Sbjct: 2052 -RERAEQESARQLQLAQEAAQ---KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2107

Query: 351  AVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQ-SEQLMGIRREEEMEMSDDENCD 409
                A+ R        +A+   +   R+ ++  R  + +E+L     E+    +  +   
Sbjct: 2108 GEAEAARRAA-----EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2162

Query: 410  SPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENLTKDQQ 469
               +K    E+A  AQA     E  +LR Q  A   E+E  K+  EQ  R +  +  +Q+
Sbjct: 2163 EKLRKEAEQEAARRAQA-----EQAALR-QKQAADAEMEKHKKFAEQTLRQKAQV--EQE 2214

Query: 470  LQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALL---KVLQEQLKGTKELV 526
            L  L+  ++    Q   + EEL   K+E  +A  ++S  +  L   +V  E+L   K  +
Sbjct: 2215 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI 2274

Query: 527  ETNGHSHEDSNEINVLTVALVNQDRENN---IEKRSQGLKSEKE 567
            E                 AL+ +D++N    +++ ++ +K   E
Sbjct: 2275 EAENR-------------ALILRDKDNTQRFLQEEAEKMKQVAE 2305



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 76/344 (22%), Positives = 144/344 (41%), Gaps = 20/344 (5%)

Query: 229  ECKQRMRAREERHRRKLEEDRLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLS 288
            E  +R R   E   + L   R R     A    ++ EA  L  +++D+S+      V L+
Sbjct: 1489 EATERQRGGAEGELQAL---RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELA 1545

Query: 289  WIERGEVNRRSANQFYSMVQSANSHVRRLMNEKATH---EQEMEEAKENFKNALTGILTQ 345
               R +    +A +    +Q+      RL  E+A     + E+E A++  + AL      
Sbjct: 1546 --SRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQ-VQVALETAQRS 1600

Query: 346  FEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSE-QLMGIRREEEMEMSD 404
             E  +    AS  +K        Q +++ + +   E  R AQ + +    R E E E+  
Sbjct: 1601 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1660

Query: 405  DENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQLFRTEENL 464
             +   +   ++R+    +A Q    + E +    Q +    E     + +EQ  R  E  
Sbjct: 1661 WQLKANEALRLRLQAEEVAQQKSLAQAEAEK---QKEEAEREARRRGKAEEQAVRQRE-- 1715

Query: 465  TKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEE-QSHTQALLKVLQEQLKGTK 523
              +Q+L+  +Q  +G  QQ L  ++EL   ++E EQ +++ Q   + L ++ +E    T+
Sbjct: 1716 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1775

Query: 524  ELVETNGHSHEDSNEINVL--TVALVNQDRENNIEKRSQGLKSE 565
            +  E      +   E+ VL  + A   ++  +  EK  Q L++E
Sbjct: 1776 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1819



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 69/328 (21%), Positives = 137/328 (41%), Gaps = 50/328 (15%)

Query: 279  FSEAITVLLSWIERGEVNRRSANQFYSMVQSANSHVRR-------LMNEKATHEQEMEEA 331
            + E+   L +W++     RR   Q  +M  + +  VR        L+ E   H +++EE 
Sbjct: 1239 YRESADPLGAWLQDA---RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEEC 1295

Query: 332  KENFKNALTGI-------LTQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELR 384
            +   K  +  I       +T   Q+  V + + + K         ++ +D+ R H  EL 
Sbjct: 1296 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDL-RTHYSELT 1354

Query: 385  NAQSEQLMGI-----RREEEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQ 439
               S+ +  I     R EEE  +++ +  +   +   V E+AL  Q   L E +   + Q
Sbjct: 1355 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV-EAALEKQRQ-LAEAHAQAKAQ 1412

Query: 440  LDAYRNEVELLKQEKEQLFRTEEN-LTKDQQLQFLQQTMQGMQQQL-------------- 484
              A R   EL ++ +E++ R EE  +   QQ + +Q+ +Q ++Q                
Sbjct: 1413 --AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1470

Query: 485  ----LTIQEELNNKKSELEQAKEEQSHTQALLKVLQEQLKGTKELVETNGHSHEDSNEIN 540
                L I+EE+   + +LE  + ++   +  L+ L+ +    +E       + E++  + 
Sbjct: 1471 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR---AEEAEAQKRQAQEEAERLR 1527

Query: 541  VLTVALVNQDRENNIEKRSQGLKSEKEA 568
                    + R+  +E  S+ +K+E EA
Sbjct: 1528 RQVQDESQRKRQAEVELASR-VKAEAEA 1554



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 74/354 (20%), Positives = 135/354 (38%), Gaps = 30/354 (8%)

Query: 231  KQRMRAREERHRRKLEED-RLRPPSPPAIMHYSEHEAALLAEKLKDDSKFSEAITVLLSW 289
            KQR+ A   R R   EE  RLR  +  A       E     ++ + +   +E +  +   
Sbjct: 1813 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI--- 1869

Query: 290  IERGEVNRRSANQFYSMVQ--SANSHVRRLMNEKATHEQEMEEAKENFKNALTGILTQFE 347
               GE  R       ++ +  + N  +RRL  ++A   + +EE     K  +   L Q  
Sbjct: 1870 ---GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1926

Query: 348  QIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEEL--RNAQSEQLMGIRREEEMEMSDD 405
            +  A  +   RQK     +  QR+ ++      EE+    A  E+    + E E+E+   
Sbjct: 1927 K--ASDSELERQKGLVEDTLRQRRQVE------EEILALKASFEKAAAGKAELELELGRI 1978

Query: 406  ENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLD-----AYRNEVELLKQEKEQLFRT 460
             +    T + +      AA+   L  E +  R + +     +   E E  +Q K  L   
Sbjct: 1979 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2038

Query: 461  EENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQ---AKEEQSHTQALLKVLQE 517
            E    K ++ + L++  +    + L + +E   K+ + E+   A   Q   Q L + LQ+
Sbjct: 2039 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2098

Query: 518  QLKGTKEL---VETNGHSHEDSNEINVLTVALVNQDRENNIEKRSQGLKSEKEA 568
            +     +L    E    + E++ E  V       Q R    E       +E++A
Sbjct: 2099 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2152



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 98/425 (23%), Positives = 177/425 (41%), Gaps = 57/425 (13%)

Query: 233  RMRAREERHRRKL---EEDRLRPPSPPAIMHYSEHEAALLAEKLKDD--SKFS---EAIT 284
            R++  E  H++ L   E  RL+  +  A    S+ E  L + +++ +  SK     EA  
Sbjct: 2219 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2278

Query: 285  VLLSWIERGEVNRRSANQFYSMVQSANSHVR-RLMNEKATHEQEMEEAKENFKNALTGIL 343
              L   ++    R    +   M Q A    R  +  ++A   +++ E     + AL   +
Sbjct: 2279 RALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKM 2338

Query: 344  TQFEQIVAVFNASTRQKAWDHFSKAQRKNIDIWRKHSEELRNAQSEQL----MGIRR--E 397
             + E++ AV  A TR KA     + Q++      +  +E +   ++QL     G +R  E
Sbjct: 2339 LK-EKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE 2396

Query: 398  EEMEMSDDENCDSPTKKMRVDESALAAQAYALKEENDSLRWQLDAYRNEVELLKQEKEQL 457
             E +   + + ++   K+RV E +  AQA A   E D+ R++  A        ++  E+L
Sbjct: 2397 AERQRQLEMSAEAERLKLRVAEMS-RAQARA---EEDAQRFRKQA--------EEIGEKL 2444

Query: 458  FRTEENLTKDQQLQFLQQTMQGMQQQLLTIQEELNNKKSELEQAKEEQSHTQALLK---- 513
             RTE      Q+   L QT++  +QQ     E L    +ELE+ KE+      LL+    
Sbjct: 2445 HRTE---LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE 2501

Query: 514  ----VLQEQLKGTKELVETNGHSHEDS---------------NEINVLTVALVNQDRENN 554
                V QEQL    + ++ +  S +DS                ++    VA   Q RE  
Sbjct: 2502 EMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ 2561

Query: 555  IEKRSQGLKSEKEALLIGIISTFLHVHPFGANIEYLWSYMQQLDSKISANEIEMLLMRLP 614
             +++ Q ++ E++ L+  +       H     +      +QQL+ +    E E+L     
Sbjct: 2562 -QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE-ELLAEENQ 2619

Query: 615  RMFKQ 619
            R+ +Q
Sbjct: 2620 RLREQ 2624


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.130    0.372 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,963,546
Number of Sequences: 37866
Number of extensions: 1239967
Number of successful extensions: 12767
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 235
Number of HSP's successfully gapped in prelim test: 832
Number of HSP's that attempted gapping in prelim test: 7682
Number of HSP's gapped (non-prelim): 3611
length of query: 643
length of database: 18,247,518
effective HSP length: 109
effective length of query: 534
effective length of database: 14,120,124
effective search space: 7540146216
effective search space used: 7540146216
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press