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Search of human proteins with 18860884
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|18860884 WW domain-containing oxidoreductase isoform 2 [Homo
sapiens]
(189 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|18860884 WW domain-containing oxidoreductase isoform 2 [Homo ... 400 e-112
gi|7706523 WW domain-containing oxidoreductase isoform 1 [Homo s... 361 e-100
gi|18860888 WW domain-containing oxidoreductase isoform 3 [Homo ... 80 1e-15
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi... 77 1e-14
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i... 74 7e-14
gi|222352183 neural precursor cell expressed, developmentally do... 69 2e-12
gi|21361472 neural precursor cell expressed, developmentally dow... 69 2e-12
gi|222352094 neural precursor cell expressed, developmentally do... 69 2e-12
gi|222352092 neural precursor cell expressed, developmentally do... 69 2e-12
gi|222352090 neural precursor cell expressed, developmentally do... 69 2e-12
gi|222352088 neural precursor cell expressed, developmentally do... 69 2e-12
gi|222352086 neural precursor cell expressed, developmentally do... 69 2e-12
gi|222352084 neural precursor cell expressed, developmentally do... 69 2e-12
gi|222352082 neural precursor cell expressed, developmentally do... 69 2e-12
gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [... 69 2e-12
gi|194306653 Yes-associated protein 1, 65kDa isoform 1 [Homo sap... 68 5e-12
gi|27436957 membrane associated guanylate kinase, WW and PDZ dom... 67 7e-12
gi|156546890 WW and C2 domain containing 2 [Homo sapiens] 65 3e-11
gi|114520609 neural precursor cell expressed, developmentally do... 65 5e-11
gi|114520607 neural precursor cell expressed, developmentally do... 65 5e-11
gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sa... 63 2e-10
gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [H... 62 2e-10
gi|29789058 WW and C2 domain containing 1 isoform 3 [Homo sapiens] 62 2e-10
gi|242247257 WW and C2 domain containing 1 isoform 2 [Homo sapiens] 62 2e-10
gi|242247251 WW and C2 domain containing 1 isoform 1 [Homo sapiens] 62 2e-10
gi|218505835 membrane-associated guanylate kinase-related 3 iso... 62 3e-10
gi|155969695 membrane-associated guanylate kinase-related 3 iso... 62 3e-10
gi|239047795 pleckstrin homology domain containing, family A mem... 59 3e-09
gi|11141889 WW45 protein [Homo sapiens] 58 4e-09
gi|186928839 retinol dehydrogenase 12 [Homo sapiens] 54 6e-08
>gi|18860884 WW domain-containing oxidoreductase isoform 2 [Homo
sapiens]
Length = 189
Score = 400 bits (1029), Expect = e-112
Identities = 189/189 (100%), Positives = 189/189 (100%)
Query: 1 MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLP 60
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLP
Sbjct: 1 MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLP 60
Query: 61 YGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKPTTRQRYDGSTTAMEILQGR 120
YGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKPTTRQRYDGSTTAMEILQGR
Sbjct: 61 YGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKPTTRQRYDGSTTAMEILQGR 120
Query: 121 DFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWKTKYHPPP 180
DFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWKTKYHPPP
Sbjct: 121 DFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWKTKYHPPP 180
Query: 181 EKCRIKIFH 189
EKCRIKIFH
Sbjct: 181 EKCRIKIFH 189
>gi|7706523 WW domain-containing oxidoreductase isoform 1 [Homo
sapiens]
Length = 414
Score = 361 bits (927), Expect = e-100
Identities = 172/172 (100%), Positives = 172/172 (100%)
Query: 1 MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLP 60
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLP
Sbjct: 1 MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLP 60
Query: 61 YGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKPTTRQRYDGSTTAMEILQGR 120
YGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKPTTRQRYDGSTTAMEILQGR
Sbjct: 61 YGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKPTTRQRYDGSTTAMEILQGR 120
Query: 121 DFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEW 172
DFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEW
Sbjct: 121 DFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEW 172
>gi|18860888 WW domain-containing oxidoreductase isoform 3 [Homo
sapiens]
Length = 36
Score = 80.1 bits (196), Expect = 1e-15
Identities = 35/35 (100%), Positives = 35/35 (100%)
Query: 1 MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYA 35
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYA
Sbjct: 1 MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYA 35
>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo
sapiens]
Length = 862
Score = 76.6 bits (187), Expect = 1e-14
Identities = 36/80 (45%), Positives = 48/80 (60%), Gaps = 1/80 (1%)
Query: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVD 77
LPPGWE+RT +G VY+ NH TQWE P++ + + LP GWE +G +FVD
Sbjct: 399 LPPGWEKRTDSNGRVYFVNHNTRITQWEDPRS-QGQLNEKPLPEGWEMRFTVDGIPYFVD 457
Query: 78 HINKRTTYLDPRLAFTVDDN 97
H + TTY+DPR + DN
Sbjct: 458 HNRRTTTYIDPRTGKSALDN 477
Score = 72.4 bits (176), Expect = 2e-13
Identities = 30/73 (41%), Positives = 44/73 (60%), Gaps = 9/73 (12%)
Query: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVD 77
LPPGWE+R + G VYY +H E++T W+ P+ LP GWE+ D G++++VD
Sbjct: 287 LPPGWEQRVDQHGRVYYVDHVEKRTTWDRPE---------PLPPGWERRVDNMGRIYYVD 337
Query: 78 HINKRTTYLDPRL 90
H + TT+ P L
Sbjct: 338 HFTRTTTWQRPTL 350
Score = 62.0 bits (149), Expect = 3e-10
Identities = 37/134 (27%), Positives = 52/134 (38%), Gaps = 39/134 (29%)
Query: 13 DSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPK------------------------ 48
D + LPPGWE R G +YY +H T W+ P
Sbjct: 314 DRPEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQF 373
Query: 49 -------------TGKRKRV--AGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRLAFT 93
T + K G LP GWE+ TD NG+V+FV+H + T + DPR
Sbjct: 374 NQRFIYGNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQ 433
Query: 94 VDDNPTKPTTRQRY 107
+++ P R+
Sbjct: 434 LNEKPLPEGWEMRF 447
Score = 40.0 bits (92), Expect = 0.001
Identities = 17/38 (44%), Positives = 22/38 (57%)
Query: 14 SEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGK 51
+E LP GWE R T DG Y+ +H T + P+TGK
Sbjct: 435 NEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGK 472
>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
isoform 1 [Homo sapiens]
Length = 870
Score = 73.9 bits (180), Expect = 7e-14
Identities = 44/101 (43%), Positives = 55/101 (54%), Gaps = 7/101 (6%)
Query: 11 DTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKT-GKRKRVAGDLPYGWEQETDE 69
D D LPPGWE+R +G VYY NH TQWE P+T G + A LP GWE +
Sbjct: 400 DHDPLGPLPPGWEKRQD-NGRVYYVNHNTRTTQWEDPRTQGMIQEPA--LPPGWEMKYTS 456
Query: 70 NGQVFFVDHINKRTTYLDPRLAFTVDDNPTKPTTRQRYDGS 110
G +FVDH + TT+ DPR F ++ TK + YD S
Sbjct: 457 EGVRYFVDHNTRTTTFKDPRPGF---ESGTKQGSPGAYDRS 494
Score = 66.2 bits (160), Expect = 2e-11
Identities = 30/73 (41%), Positives = 40/73 (54%), Gaps = 11/73 (15%)
Query: 16 DELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFF 75
D LP GWE+R +G VYY +H + T WE P LP GWE+ TD G+ ++
Sbjct: 300 DALPAGWEQRELPNGRVYYVDHNTKTTTWERP-----------LPPGWEKRTDPRGRFYY 348
Query: 76 VDHINKRTTYLDP 88
VDH + TT+ P
Sbjct: 349 VDHNTRTTTWQRP 361
Score = 57.4 bits (137), Expect = 7e-09
Identities = 36/130 (27%), Positives = 52/130 (40%), Gaps = 35/130 (26%)
Query: 12 TDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKT----------GKRKRV------ 55
T E LPPGWE+RT G YY +H T W+ P +R ++
Sbjct: 326 TTWERPLPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQH 385
Query: 56 ------------------AGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVDDN 97
G LP GWE+ D NG+V++V+H + T + DPR + +
Sbjct: 386 FSQRFLYQSSSASTDHDPLGPLPPGWEKRQD-NGRVYYVNHNTRTTQWEDPRTQGMIQEP 444
Query: 98 PTKPTTRQRY 107
P +Y
Sbjct: 445 ALPPGWEMKY 454
>gi|222352183 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 69.3 bits (168), Expect = 2e-12
Identities = 37/104 (35%), Positives = 51/104 (49%), Gaps = 13/104 (12%)
Query: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHP----------KTGKRKRVAGDLPYGWEQET 67
LPPGWE R +G ++ +H + T WE P KT G LP GWE+
Sbjct: 378 LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERI 437
Query: 68 DENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKPTTR---QRYD 108
+G+ F++DH +K T + DPRL P P +R Q+YD
Sbjct: 438 HLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYD 481
Score = 43.1 bits (100), Expect = 1e-04
Identities = 16/30 (53%), Positives = 17/30 (56%)
Query: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHP 47
LPPGWEE+ G YY NH TQW P
Sbjct: 74 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 39.7 bits (91), Expect = 0.002
Identities = 23/81 (28%), Positives = 39/81 (48%), Gaps = 16/81 (19%)
Query: 10 DDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDE 69
+++D D++ GWE V +N + + Q E P LP GWE++ D
Sbjct: 41 ENSDQRDDMEHGWE--------VVDSNDSASQHQEELPPP--------PLPPGWEEKVDN 84
Query: 70 NGQVFFVDHINKRTTYLDPRL 90
G+ ++V+H N+ T + P L
Sbjct: 85 LGRTYYVNHNNRTTQWHRPSL 105
Score = 38.9 bits (89), Expect = 0.003
Identities = 15/30 (50%), Positives = 15/30 (50%)
Query: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHP 47
LP GWEER G YY NH T W P
Sbjct: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRP 295
Score = 37.4 bits (85), Expect = 0.008
Identities = 14/37 (37%), Positives = 22/37 (59%)
Query: 59 LPYGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVD 95
LP GWE+ D G+ ++V+H N+ TT+ P + D
Sbjct: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAED 302
>gi|21361472 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 3 [Homo sapiens]
Length = 955
Score = 69.3 bits (168), Expect = 2e-12
Identities = 37/104 (35%), Positives = 51/104 (49%), Gaps = 13/104 (12%)
Query: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHP----------KTGKRKRVAGDLPYGWEQET 67
LPPGWE R +G ++ +H + T WE P KT G LP GWE+
Sbjct: 479 LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERI 538
Query: 68 DENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKPTTR---QRYD 108
+G+ F++DH +K T + DPRL P P +R Q+YD
Sbjct: 539 HLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYD 582
Score = 43.1 bits (100), Expect = 1e-04
Identities = 16/30 (53%), Positives = 17/30 (56%)
Query: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHP 47
LPPGWEE+ G YY NH TQW P
Sbjct: 195 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 224
Score = 39.7 bits (91), Expect = 0.002
Identities = 23/81 (28%), Positives = 39/81 (48%), Gaps = 16/81 (19%)
Query: 10 DDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDE 69
+++D D++ GWE V +N + + Q E P LP GWE++ D
Sbjct: 162 ENSDQRDDMEHGWE--------VVDSNDSASQHQEELPPP--------PLPPGWEEKVDN 205
Query: 70 NGQVFFVDHINKRTTYLDPRL 90
G+ ++V+H N+ T + P L
Sbjct: 206 LGRTYYVNHNNRTTQWHRPSL 226
Score = 38.9 bits (89), Expect = 0.003
Identities = 15/30 (50%), Positives = 15/30 (50%)
Query: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHP 47
LP GWEER G YY NH T W P
Sbjct: 367 LPSGWEERKDAKGRTYYVNHNNRTTTWTRP 396
Score = 37.4 bits (85), Expect = 0.008
Identities = 14/37 (37%), Positives = 22/37 (59%)
Query: 59 LPYGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVD 95
LP GWE+ D G+ ++V+H N+ TT+ P + D
Sbjct: 367 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAED 403
>gi|222352094 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 69.3 bits (168), Expect = 2e-12
Identities = 37/104 (35%), Positives = 51/104 (49%), Gaps = 13/104 (12%)
Query: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHP----------KTGKRKRVAGDLPYGWEQET 67
LPPGWE R +G ++ +H + T WE P KT G LP GWE+
Sbjct: 358 LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERI 417
Query: 68 DENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKPTTR---QRYD 108
+G+ F++DH +K T + DPRL P P +R Q+YD
Sbjct: 418 HLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYD 461
Score = 43.1 bits (100), Expect = 1e-04
Identities = 16/30 (53%), Positives = 17/30 (56%)
Query: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHP 47
LPPGWEE+ G YY NH TQW P
Sbjct: 74 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 39.7 bits (91), Expect = 0.002
Identities = 23/81 (28%), Positives = 39/81 (48%), Gaps = 16/81 (19%)
Query: 10 DDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDE 69
+++D D++ GWE V +N + + Q E P LP GWE++ D
Sbjct: 41 ENSDQRDDMEHGWE--------VVDSNDSASQHQEELPPP--------PLPPGWEEKVDN 84
Query: 70 NGQVFFVDHINKRTTYLDPRL 90
G+ ++V+H N+ T + P L
Sbjct: 85 LGRTYYVNHNNRTTQWHRPSL 105
Score = 38.9 bits (89), Expect = 0.003
Identities = 15/30 (50%), Positives = 15/30 (50%)
Query: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHP 47
LP GWEER G YY NH T W P
Sbjct: 246 LPSGWEERKDAKGRTYYVNHNNRTTTWTRP 275
Score = 37.4 bits (85), Expect = 0.008
Identities = 14/37 (37%), Positives = 22/37 (59%)
Query: 59 LPYGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVD 95
LP GWE+ D G+ ++V+H N+ TT+ P + D
Sbjct: 246 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAED 282
>gi|222352092 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 69.3 bits (168), Expect = 2e-12
Identities = 37/104 (35%), Positives = 51/104 (49%), Gaps = 13/104 (12%)
Query: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHP----------KTGKRKRVAGDLPYGWEQET 67
LPPGWE R +G ++ +H + T WE P KT G LP GWE+
Sbjct: 358 LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERI 417
Query: 68 DENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKPTTR---QRYD 108
+G+ F++DH +K T + DPRL P P +R Q+YD
Sbjct: 418 HLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYD 461
Score = 43.1 bits (100), Expect = 1e-04
Identities = 16/30 (53%), Positives = 17/30 (56%)
Query: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHP 47
LPPGWEE+ G YY NH TQW P
Sbjct: 74 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 39.7 bits (91), Expect = 0.002
Identities = 23/81 (28%), Positives = 39/81 (48%), Gaps = 16/81 (19%)
Query: 10 DDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDE 69
+++D D++ GWE V +N + + Q E P LP GWE++ D
Sbjct: 41 ENSDQRDDMEHGWE--------VVDSNDSASQHQEELPPP--------PLPPGWEEKVDN 84
Query: 70 NGQVFFVDHINKRTTYLDPRL 90
G+ ++V+H N+ T + P L
Sbjct: 85 LGRTYYVNHNNRTTQWHRPSL 105
Score = 38.9 bits (89), Expect = 0.003
Identities = 15/30 (50%), Positives = 15/30 (50%)
Query: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHP 47
LP GWEER G YY NH T W P
Sbjct: 246 LPSGWEERKDAKGRTYYVNHNNRTTTWTRP 275
Score = 37.4 bits (85), Expect = 0.008
Identities = 14/37 (37%), Positives = 22/37 (59%)
Query: 59 LPYGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVD 95
LP GWE+ D G+ ++V+H N+ TT+ P + D
Sbjct: 246 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAED 282
>gi|222352090 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 5 [Homo sapiens]
Length = 947
Score = 69.3 bits (168), Expect = 2e-12
Identities = 37/104 (35%), Positives = 51/104 (49%), Gaps = 13/104 (12%)
Query: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHP----------KTGKRKRVAGDLPYGWEQET 67
LPPGWE R +G ++ +H + T WE P KT G LP GWE+
Sbjct: 471 LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERI 530
Query: 68 DENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKPTTR---QRYD 108
+G+ F++DH +K T + DPRL P P +R Q+YD
Sbjct: 531 HLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYD 574
Score = 43.1 bits (100), Expect = 1e-04
Identities = 16/30 (53%), Positives = 17/30 (56%)
Query: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHP 47
LPPGWEE+ G YY NH TQW P
Sbjct: 187 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 216
Score = 39.7 bits (91), Expect = 0.002
Identities = 23/81 (28%), Positives = 39/81 (48%), Gaps = 16/81 (19%)
Query: 10 DDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDE 69
+++D D++ GWE V +N + + Q E P LP GWE++ D
Sbjct: 154 ENSDQRDDMEHGWE--------VVDSNDSASQHQEELPPP--------PLPPGWEEKVDN 197
Query: 70 NGQVFFVDHINKRTTYLDPRL 90
G+ ++V+H N+ T + P L
Sbjct: 198 LGRTYYVNHNNRTTQWHRPSL 218
Score = 38.9 bits (89), Expect = 0.003
Identities = 15/30 (50%), Positives = 15/30 (50%)
Query: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHP 47
LP GWEER G YY NH T W P
Sbjct: 359 LPSGWEERKDAKGRTYYVNHNNRTTTWTRP 388
Score = 37.4 bits (85), Expect = 0.008
Identities = 14/37 (37%), Positives = 22/37 (59%)
Query: 59 LPYGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVD 95
LP GWE+ D G+ ++V+H N+ TT+ P + D
Sbjct: 359 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAED 395
>gi|222352088 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 4 [Homo sapiens]
Length = 967
Score = 69.3 bits (168), Expect = 2e-12
Identities = 37/104 (35%), Positives = 51/104 (49%), Gaps = 13/104 (12%)
Query: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHP----------KTGKRKRVAGDLPYGWEQET 67
LPPGWE R +G ++ +H + T WE P KT G LP GWE+
Sbjct: 491 LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERI 550
Query: 68 DENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKPTTR---QRYD 108
+G+ F++DH +K T + DPRL P P +R Q+YD
Sbjct: 551 HLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYD 594
Score = 43.1 bits (100), Expect = 1e-04
Identities = 16/30 (53%), Positives = 17/30 (56%)
Query: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHP 47
LPPGWEE+ G YY NH TQW P
Sbjct: 187 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 216
Score = 39.7 bits (91), Expect = 0.002
Identities = 23/81 (28%), Positives = 39/81 (48%), Gaps = 16/81 (19%)
Query: 10 DDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDE 69
+++D D++ GWE V +N + + Q E P LP GWE++ D
Sbjct: 154 ENSDQRDDMEHGWE--------VVDSNDSASQHQEELPPP--------PLPPGWEEKVDN 197
Query: 70 NGQVFFVDHINKRTTYLDPRL 90
G+ ++V+H N+ T + P L
Sbjct: 198 LGRTYYVNHNNRTTQWHRPSL 218
Score = 38.9 bits (89), Expect = 0.003
Identities = 15/30 (50%), Positives = 15/30 (50%)
Query: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHP 47
LP GWEER G YY NH T W P
Sbjct: 379 LPSGWEERKDAKGRTYYVNHNNRTTTWTRP 408
Score = 37.4 bits (85), Expect = 0.008
Identities = 14/37 (37%), Positives = 22/37 (59%)
Query: 59 LPYGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVD 95
LP GWE+ D G+ ++V+H N+ TT+ P + D
Sbjct: 379 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAED 415
>gi|222352086 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 1 [Homo sapiens]
Length = 975
Score = 69.3 bits (168), Expect = 2e-12
Identities = 37/104 (35%), Positives = 51/104 (49%), Gaps = 13/104 (12%)
Query: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHP----------KTGKRKRVAGDLPYGWEQET 67
LPPGWE R +G ++ +H + T WE P KT G LP GWE+
Sbjct: 499 LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERI 558
Query: 68 DENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKPTTR---QRYD 108
+G+ F++DH +K T + DPRL P P +R Q+YD
Sbjct: 559 HLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYD 602
Score = 43.1 bits (100), Expect = 1e-04
Identities = 16/30 (53%), Positives = 17/30 (56%)
Query: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHP 47
LPPGWEE+ G YY NH TQW P
Sbjct: 195 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 224
Score = 39.7 bits (91), Expect = 0.002
Identities = 23/81 (28%), Positives = 39/81 (48%), Gaps = 16/81 (19%)
Query: 10 DDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDE 69
+++D D++ GWE V +N + + Q E P LP GWE++ D
Sbjct: 162 ENSDQRDDMEHGWE--------VVDSNDSASQHQEELPPP--------PLPPGWEEKVDN 205
Query: 70 NGQVFFVDHINKRTTYLDPRL 90
G+ ++V+H N+ T + P L
Sbjct: 206 LGRTYYVNHNNRTTQWHRPSL 226
Score = 38.9 bits (89), Expect = 0.003
Identities = 15/30 (50%), Positives = 15/30 (50%)
Query: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHP 47
LP GWEER G YY NH T W P
Sbjct: 387 LPSGWEERKDAKGRTYYVNHNNRTTTWTRP 416
Score = 37.4 bits (85), Expect = 0.008
Identities = 14/37 (37%), Positives = 22/37 (59%)
Query: 59 LPYGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVD 95
LP GWE+ D G+ ++V+H N+ TT+ P + D
Sbjct: 387 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAED 423
>gi|222352084 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 69.3 bits (168), Expect = 2e-12
Identities = 37/104 (35%), Positives = 51/104 (49%), Gaps = 13/104 (12%)
Query: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHP----------KTGKRKRVAGDLPYGWEQET 67
LPPGWE R +G ++ +H + T WE P KT G LP GWE+
Sbjct: 378 LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERI 437
Query: 68 DENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKPTTR---QRYD 108
+G+ F++DH +K T + DPRL P P +R Q+YD
Sbjct: 438 HLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYD 481
Score = 43.1 bits (100), Expect = 1e-04
Identities = 16/30 (53%), Positives = 17/30 (56%)
Query: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHP 47
LPPGWEE+ G YY NH TQW P
Sbjct: 74 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 39.7 bits (91), Expect = 0.002
Identities = 23/81 (28%), Positives = 39/81 (48%), Gaps = 16/81 (19%)
Query: 10 DDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDE 69
+++D D++ GWE V +N + + Q E P LP GWE++ D
Sbjct: 41 ENSDQRDDMEHGWE--------VVDSNDSASQHQEELPPP--------PLPPGWEEKVDN 84
Query: 70 NGQVFFVDHINKRTTYLDPRL 90
G+ ++V+H N+ T + P L
Sbjct: 85 LGRTYYVNHNNRTTQWHRPSL 105
Score = 38.9 bits (89), Expect = 0.003
Identities = 15/30 (50%), Positives = 15/30 (50%)
Query: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHP 47
LP GWEER G YY NH T W P
Sbjct: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRP 295
Score = 37.4 bits (85), Expect = 0.008
Identities = 14/37 (37%), Positives = 22/37 (59%)
Query: 59 LPYGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVD 95
LP GWE+ D G+ ++V+H N+ TT+ P + D
Sbjct: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAED 302
>gi|222352082 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 69.3 bits (168), Expect = 2e-12
Identities = 37/104 (35%), Positives = 51/104 (49%), Gaps = 13/104 (12%)
Query: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHP----------KTGKRKRVAGDLPYGWEQET 67
LPPGWE R +G ++ +H + T WE P KT G LP GWE+
Sbjct: 378 LPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERI 437
Query: 68 DENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKPTTR---QRYD 108
+G+ F++DH +K T + DPRL P P +R Q+YD
Sbjct: 438 HLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYD 481
Score = 43.1 bits (100), Expect = 1e-04
Identities = 16/30 (53%), Positives = 17/30 (56%)
Query: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHP 47
LPPGWEE+ G YY NH TQW P
Sbjct: 74 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRP 103
Score = 39.7 bits (91), Expect = 0.002
Identities = 23/81 (28%), Positives = 39/81 (48%), Gaps = 16/81 (19%)
Query: 10 DDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDE 69
+++D D++ GWE V +N + + Q E P LP GWE++ D
Sbjct: 41 ENSDQRDDMEHGWE--------VVDSNDSASQHQEELPPP--------PLPPGWEEKVDN 84
Query: 70 NGQVFFVDHINKRTTYLDPRL 90
G+ ++V+H N+ T + P L
Sbjct: 85 LGRTYYVNHNNRTTQWHRPSL 105
Score = 38.9 bits (89), Expect = 0.003
Identities = 15/30 (50%), Positives = 15/30 (50%)
Query: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHP 47
LP GWEER G YY NH T W P
Sbjct: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRP 295
Score = 37.4 bits (85), Expect = 0.008
Identities = 14/37 (37%), Positives = 22/37 (59%)
Query: 59 LPYGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVD 95
LP GWE+ D G+ ++V+H N+ TT+ P + D
Sbjct: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAED 302
>gi|13654239 WW domain containing E3 ubiquitin protein ligase 1
[Homo sapiens]
Length = 922
Score = 69.3 bits (168), Expect = 2e-12
Identities = 33/79 (41%), Positives = 43/79 (54%), Gaps = 1/79 (1%)
Query: 11 DTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDEN 70
+ D LPPGWE+R VY+ NH + TQWE P+T + + LP GWE
Sbjct: 451 ENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRT-QGLQNEEPLPEGWEIRYTRE 509
Query: 71 GQVFFVDHINKRTTYLDPR 89
G +FVDH + TT+ DPR
Sbjct: 510 GVRYFVDHNTRTTTFKDPR 528
Score = 61.2 bits (147), Expect = 5e-10
Identities = 27/75 (36%), Positives = 39/75 (52%), Gaps = 9/75 (12%)
Query: 16 DELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFF 75
+ LP GWE+R G YY +H T WE P+ LP GWE+ D+ +V++
Sbjct: 349 ETLPSGWEQRKDPHGRTYYVDHNTRTTTWERPQ---------PLPPGWERRVDDRRRVYY 399
Query: 76 VDHINKRTTYLDPRL 90
VDH + TT+ P +
Sbjct: 400 VDHNTRTTTWQRPTM 414
Score = 53.9 bits (128), Expect = 8e-08
Identities = 34/124 (27%), Positives = 46/124 (37%), Gaps = 34/124 (27%)
Query: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHPKT----------GKRKRVAG---------- 57
LPPGWE R VYY +H T W+ P +R ++ G
Sbjct: 383 LPPGWERRVDDRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRYL 442
Query: 58 --------------DLPYGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKPTT 103
LP GWE+ D +V+FV+H K T + DPR ++ P
Sbjct: 443 YSASMLAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQGLQNEEPLPEGW 502
Query: 104 RQRY 107
RY
Sbjct: 503 EIRY 506
Score = 40.4 bits (93), Expect = 0.001
Identities = 17/52 (32%), Positives = 28/52 (53%)
Query: 14 SEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQ 65
+E+ LP GWE R T++G Y+ +H T ++ P+ GK G +E+
Sbjct: 494 NEEPLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGKSSVTKGGPQIAYER 545
>gi|194306653 Yes-associated protein 1, 65kDa isoform 1 [Homo
sapiens]
Length = 504
Score = 67.8 bits (164), Expect = 5e-12
Identities = 30/91 (32%), Positives = 48/91 (52%), Gaps = 18/91 (19%)
Query: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRV------------------AGDL 59
LP GWE T G Y+ NH ++ T W+ P+ ++ +G L
Sbjct: 173 LPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPL 232
Query: 60 PYGWEQETDENGQVFFVDHINKRTTYLDPRL 90
P GWEQ ++G++++++H NK T++LDPRL
Sbjct: 233 PDGWEQAMTQDGEIYYINHKNKTTSWLDPRL 263
Score = 45.4 bits (106), Expect = 3e-05
Identities = 20/45 (44%), Positives = 28/45 (62%)
Query: 59 LPYGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKPTT 103
LP GWE +GQ +F++HI++ TT+ DPR A N T PT+
Sbjct: 173 LPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTS 217
Score = 42.7 bits (99), Expect = 2e-04
Identities = 16/35 (45%), Positives = 21/35 (60%)
Query: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKR 52
LP GWE+ T+DG +YY NH + T W P+ R
Sbjct: 232 LPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPR 266
>gi|27436957 membrane associated guanylate kinase, WW and PDZ domain
containing 2 [Homo sapiens]
Length = 1455
Score = 67.4 bits (163), Expect = 7e-12
Identities = 31/86 (36%), Positives = 47/86 (54%), Gaps = 5/86 (5%)
Query: 10 DDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKR-----VAGDLPYGWE 64
+D + D LP WE T+ G VY+ +H + T W P+ K+ + +LPYGWE
Sbjct: 296 EDNEEPDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEECKENELPYGWE 355
Query: 65 QETDENGQVFFVDHINKRTTYLDPRL 90
+ D ++VDHIN+RT + +P L
Sbjct: 356 KIDDPIYGTYYVDHINRRTQFENPVL 381
Score = 45.1 bits (105), Expect = 4e-05
Identities = 24/60 (40%), Positives = 32/60 (53%), Gaps = 2/60 (3%)
Query: 34 YANHTEEKTQWEHPKTGKRK--RVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRLA 91
Y+ E K Q + K K + LP WE E G+V+F+DH K T++LDPRLA
Sbjct: 277 YSQPEELKEQMDDTKPTKPEDNEEPDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLA 336
Score = 35.8 bits (81), Expect = 0.023
Identities = 18/48 (37%), Positives = 27/48 (56%), Gaps = 1/48 (2%)
Query: 15 EDELPPGWEERTTKDGWVYYANHTEEKTQWEHP-KTGKRKRVAGDLPY 61
E+ELP GWE+ YY +H +TQ+E+P KRK ++P+
Sbjct: 347 ENELPYGWEKIDDPIYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPH 394
>gi|156546890 WW and C2 domain containing 2 [Homo sapiens]
Length = 1192
Score = 65.1 bits (157), Expect = 3e-11
Identities = 32/78 (41%), Positives = 41/78 (52%), Gaps = 6/78 (7%)
Query: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKR------VAGDLPYGWEQETDENG 71
LP GWEE DG V+Y +H +T W P+ K V +LP+GWE D
Sbjct: 12 LPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFADCVGDELPWGWEAGFDPQI 71
Query: 72 QVFFVDHINKRTTYLDPR 89
V+++DHINK T DPR
Sbjct: 72 GVYYIDHINKTTQIEDPR 89
Score = 46.2 bits (108), Expect = 2e-05
Identities = 20/43 (46%), Positives = 29/43 (67%), Gaps = 6/43 (13%)
Query: 59 LPYGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKP 101
LP GWE+ D +G+VF++DH +RT+++DPR D TKP
Sbjct: 12 LPRGWEEARDYDGKVFYIDHNTRRTSWIDPR------DRLTKP 48
Score = 32.3 bits (72), Expect = 0.25
Identities = 15/33 (45%), Positives = 18/33 (54%)
Query: 16 DELPPGWEERTTKDGWVYYANHTEEKTQWEHPK 48
DELP GWE VYY +H + TQ E P+
Sbjct: 57 DELPWGWEAGFDPQIGVYYIDHINKTTQIEDPR 89
>gi|114520609 neural precursor cell expressed, developmentally
down-regulated 4 isoform 1 [Homo sapiens]
Length = 900
Score = 64.7 bits (156), Expect = 5e-11
Identities = 34/98 (34%), Positives = 49/98 (50%), Gaps = 11/98 (11%)
Query: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHPKT-------GKRK----RVAGDLPYGWEQE 66
LP GWE R +G ++ +H + T WE P+ GK G LP GWE+
Sbjct: 423 LPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWEER 482
Query: 67 TDENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKPTTR 104
T +G++F+++H KRT + DPRL P P +R
Sbjct: 483 THTDGRIFYINHNIKRTQWEDPRLENVAITGPAVPYSR 520
Score = 58.5 bits (140), Expect = 3e-09
Identities = 34/105 (32%), Positives = 43/105 (40%), Gaps = 32/105 (30%)
Query: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHP----------------KTGKRKRVA----- 56
LPPGWEE+ + G YY +H T W P G + + +
Sbjct: 350 LPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSG 409
Query: 57 -----------GDLPYGWEQETDENGQVFFVDHINKRTTYLDPRL 90
G LP GWE NG+ FF+DH K TT+ DPRL
Sbjct: 410 QQVTQPSEIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRL 454
Score = 53.9 bits (128), Expect = 8e-08
Identities = 23/53 (43%), Positives = 31/53 (58%)
Query: 9 LDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPY 61
LD ++ LPPGWEERT DG ++Y NH ++TQWE P+ +PY
Sbjct: 466 LDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAITGPAVPY 518
Score = 44.3 bits (103), Expect = 6e-05
Identities = 18/39 (46%), Positives = 20/39 (51%)
Query: 9 LDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHP 47
L LPPGWEER G YY NH +TQW+ P
Sbjct: 184 LQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRP 222
Score = 41.6 bits (96), Expect = 4e-04
Identities = 16/37 (43%), Positives = 26/37 (70%)
Query: 59 LPYGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVD 95
LP GWE++ DE G+ ++VDH ++ TT+ P + TV+
Sbjct: 350 LPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVE 386
Score = 37.7 bits (86), Expect = 0.006
Identities = 25/90 (27%), Positives = 40/90 (44%), Gaps = 20/90 (22%)
Query: 10 DDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDE 69
D+ + +EL PGW D A H +++ + LP GWE+ D
Sbjct: 160 DNAEQAEELEPGWVVLDQPDA----ACHLQQQQE------------PSPLPPGWEERQDI 203
Query: 70 NGQVFFVDHINKRTTYLDPRLAFTVDDNPT 99
G+ ++V+H ++RT + P T DN T
Sbjct: 204 LGRTYYVNHESRRTQWKRP----TPQDNLT 229
>gi|114520607 neural precursor cell expressed, developmentally
down-regulated 4 isoform 2 [Homo sapiens]
Length = 1247
Score = 64.7 bits (156), Expect = 5e-11
Identities = 34/98 (34%), Positives = 49/98 (50%), Gaps = 11/98 (11%)
Query: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHPKT-------GKRK----RVAGDLPYGWEQE 66
LP GWE R +G ++ +H + T WE P+ GK G LP GWE+
Sbjct: 770 LPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWEER 829
Query: 67 TDENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKPTTR 104
T +G++F+++H KRT + DPRL P P +R
Sbjct: 830 THTDGRIFYINHNIKRTQWEDPRLENVAITGPAVPYSR 867
Score = 58.5 bits (140), Expect = 3e-09
Identities = 34/105 (32%), Positives = 43/105 (40%), Gaps = 32/105 (30%)
Query: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHP----------------KTGKRKRVA----- 56
LPPGWEE+ + G YY +H T W P G + + +
Sbjct: 697 LPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSG 756
Query: 57 -----------GDLPYGWEQETDENGQVFFVDHINKRTTYLDPRL 90
G LP GWE NG+ FF+DH K TT+ DPRL
Sbjct: 757 QQVTQPSEIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRL 801
Score = 53.9 bits (128), Expect = 8e-08
Identities = 23/53 (43%), Positives = 31/53 (58%)
Query: 9 LDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPY 61
LD ++ LPPGWEERT DG ++Y NH ++TQWE P+ +PY
Sbjct: 813 LDTSNDLGPLPPGWEERTHTDGRIFYINHNIKRTQWEDPRLENVAITGPAVPY 865
Score = 44.3 bits (103), Expect = 6e-05
Identities = 18/39 (46%), Positives = 20/39 (51%)
Query: 9 LDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHP 47
L LPPGWEER G YY NH +TQW+ P
Sbjct: 531 LQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRP 569
Score = 41.6 bits (96), Expect = 4e-04
Identities = 16/37 (43%), Positives = 26/37 (70%)
Query: 59 LPYGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVD 95
LP GWE++ DE G+ ++VDH ++ TT+ P + TV+
Sbjct: 697 LPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVE 733
Score = 32.7 bits (73), Expect = 0.19
Identities = 16/41 (39%), Positives = 24/41 (58%), Gaps = 4/41 (9%)
Query: 59 LPYGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVDDNPT 99
LP GWE+ D G+ ++V+H ++RT + P T DN T
Sbjct: 540 LPPGWEERQDILGRTYYVNHESRRTQWKRP----TPQDNLT 576
>gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo
sapiens]
Length = 748
Score = 62.8 bits (151), Expect = 2e-10
Identities = 30/80 (37%), Positives = 44/80 (55%), Gaps = 5/80 (6%)
Query: 17 ELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGK-----RKRVAGDLPYGWEQETDENG 71
+LP G+E+RTT+ G VY+ + + W P+ + G LP GWE G
Sbjct: 252 DLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVPRDLSNINCEELGPLPPGWEIRNTATG 311
Query: 72 QVFFVDHINKRTTYLDPRLA 91
+V+FVDH N+ T + DPRL+
Sbjct: 312 RVYFVDHNNRTTQFTDPRLS 331
Score = 45.1 bits (105), Expect = 4e-05
Identities = 17/33 (51%), Positives = 21/33 (63%)
Query: 15 EDELPPGWEERTTKDGWVYYANHTEEKTQWEHP 47
+++LP GWEER T G + Y NH TQWE P
Sbjct: 156 DNDLPDGWEERRTASGRIQYLNHITRTTQWERP 188
Score = 33.1 bits (74), Expect = 0.15
Identities = 13/44 (29%), Positives = 25/44 (56%)
Query: 58 DLPYGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKP 101
DLP GWE+ +G++ +++HI + T + P + +P +P
Sbjct: 158 DLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRP 201
>gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [Homo
sapiens]
Length = 731
Score = 62.4 bits (150), Expect = 2e-10
Identities = 30/79 (37%), Positives = 44/79 (55%), Gaps = 5/79 (6%)
Query: 17 ELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVA-----GDLPYGWEQETDENG 71
ELP G+E+RTT G VY+ + + W P+ + G LP GWE + +G
Sbjct: 235 ELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPRDLNSVNCDELGPLPPGWEVRSTVSG 294
Query: 72 QVFFVDHINKRTTYLDPRL 90
+++FVDH N+ T + DPRL
Sbjct: 295 RIYFVDHNNRTTQFTDPRL 313
Score = 39.3 bits (90), Expect = 0.002
Identities = 15/36 (41%), Positives = 21/36 (58%)
Query: 13 DSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPK 48
D LPPGWE R+T G +Y+ +H TQ+ P+
Sbjct: 277 DELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPR 312
>gi|29789058 WW and C2 domain containing 1 isoform 3 [Homo
sapiens]
Length = 1113
Score = 62.4 bits (150), Expect = 2e-10
Identities = 31/79 (39%), Positives = 40/79 (50%), Gaps = 6/79 (7%)
Query: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKR------VAGDLPYGWEQETDENG 71
LP GWEE DG VYY +HT T W P+ K ++ +LP GWE+ D
Sbjct: 8 LPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWEEAYDPQV 67
Query: 72 QVFFVDHINKRTTYLDPRL 90
+F+DH K T DPR+
Sbjct: 68 GDYFIDHNTKTTQIEDPRV 86
Score = 47.0 bits (110), Expect = 1e-05
Identities = 20/45 (44%), Positives = 30/45 (66%), Gaps = 6/45 (13%)
Query: 59 LPYGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKPTT 103
LP GWE+ D +G+V+++DH N+ T+++DPR D TKP T
Sbjct: 8 LPEGWEEARDFDGKVYYIDHTNRTTSWIDPR------DRYTKPLT 46
Score = 32.3 bits (72), Expect = 0.25
Identities = 15/38 (39%), Positives = 20/38 (52%)
Query: 16 DELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRK 53
DELP GWEE Y+ +H + TQ E P+ R+
Sbjct: 53 DELPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRVQWRR 90
>gi|242247257 WW and C2 domain containing 1 isoform 2 [Homo
sapiens]
Length = 1118
Score = 62.4 bits (150), Expect = 2e-10
Identities = 31/79 (39%), Positives = 40/79 (50%), Gaps = 6/79 (7%)
Query: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKR------VAGDLPYGWEQETDENG 71
LP GWEE DG VYY +HT T W P+ K ++ +LP GWE+ D
Sbjct: 8 LPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWEEAYDPQV 67
Query: 72 QVFFVDHINKRTTYLDPRL 90
+F+DH K T DPR+
Sbjct: 68 GDYFIDHNTKTTQIEDPRV 86
Score = 47.0 bits (110), Expect = 1e-05
Identities = 20/45 (44%), Positives = 30/45 (66%), Gaps = 6/45 (13%)
Query: 59 LPYGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKPTT 103
LP GWE+ D +G+V+++DH N+ T+++DPR D TKP T
Sbjct: 8 LPEGWEEARDFDGKVYYIDHTNRTTSWIDPR------DRYTKPLT 46
Score = 32.3 bits (72), Expect = 0.25
Identities = 15/38 (39%), Positives = 20/38 (52%)
Query: 16 DELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRK 53
DELP GWEE Y+ +H + TQ E P+ R+
Sbjct: 53 DELPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRVQWRR 90
>gi|242247251 WW and C2 domain containing 1 isoform 1 [Homo
sapiens]
Length = 1119
Score = 62.4 bits (150), Expect = 2e-10
Identities = 31/79 (39%), Positives = 40/79 (50%), Gaps = 6/79 (7%)
Query: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKR------VAGDLPYGWEQETDENG 71
LP GWEE DG VYY +HT T W P+ K ++ +LP GWE+ D
Sbjct: 8 LPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKPLTFADCISDELPLGWEEAYDPQV 67
Query: 72 QVFFVDHINKRTTYLDPRL 90
+F+DH K T DPR+
Sbjct: 68 GDYFIDHNTKTTQIEDPRV 86
Score = 47.0 bits (110), Expect = 1e-05
Identities = 20/45 (44%), Positives = 30/45 (66%), Gaps = 6/45 (13%)
Query: 59 LPYGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKPTT 103
LP GWE+ D +G+V+++DH N+ T+++DPR D TKP T
Sbjct: 8 LPEGWEEARDFDGKVYYIDHTNRTTSWIDPR------DRYTKPLT 46
Score = 32.3 bits (72), Expect = 0.25
Identities = 15/38 (39%), Positives = 20/38 (52%)
Query: 16 DELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRK 53
DELP GWEE Y+ +H + TQ E P+ R+
Sbjct: 53 DELPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRVQWRR 90
>gi|218505835 membrane-associated guanylate kinase-related 3
isoform 1 [Homo sapiens]
Length = 1481
Score = 62.0 bits (149), Expect = 3e-10
Identities = 26/78 (33%), Positives = 43/78 (55%), Gaps = 5/78 (6%)
Query: 16 DELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVA-----GDLPYGWEQETDEN 70
+ LP WE T G +Y+ +H + T W P+ K+ + G+LPYGWE+ D
Sbjct: 293 EPLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRLCKKAKAPEDCEDGELPYGWEKIEDPQ 352
Query: 71 GQVFFVDHINKRTTYLDP 88
++VDH+N++T + +P
Sbjct: 353 YGTYYVDHLNQKTQFENP 370
Score = 42.0 bits (97), Expect = 3e-04
Identities = 16/32 (50%), Positives = 21/32 (65%)
Query: 59 LPYGWEQETDENGQVFFVDHINKRTTYLDPRL 90
LP WE + G ++F+DH K TT+LDPRL
Sbjct: 295 LPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRL 326
Score = 41.2 bits (95), Expect = 5e-04
Identities = 22/52 (42%), Positives = 30/52 (57%), Gaps = 2/52 (3%)
Query: 13 DSED-ELPPGWEERTTKDGWVYYANHTEEKTQWEHP-KTGKRKRVAGDLPYG 62
D ED ELP GWE+ YY +H +KTQ+E+P + KRK+ G + G
Sbjct: 335 DCEDGELPYGWEKIEDPQYGTYYVDHLNQKTQFENPVEEAKRKKQLGQVEIG 386
>gi|155969695 membrane-associated guanylate kinase-related 3
isoform 2 [Homo sapiens]
Length = 1125
Score = 62.0 bits (149), Expect = 3e-10
Identities = 26/78 (33%), Positives = 43/78 (55%), Gaps = 5/78 (6%)
Query: 16 DELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVA-----GDLPYGWEQETDEN 70
+ LP WE T G +Y+ +H + T W P+ K+ + G+LPYGWE+ D
Sbjct: 293 EPLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRLCKKAKAPEDCEDGELPYGWEKIEDPQ 352
Query: 71 GQVFFVDHINKRTTYLDP 88
++VDH+N++T + +P
Sbjct: 353 YGTYYVDHLNQKTQFENP 370
Score = 42.0 bits (97), Expect = 3e-04
Identities = 16/32 (50%), Positives = 21/32 (65%)
Query: 59 LPYGWEQETDENGQVFFVDHINKRTTYLDPRL 90
LP WE + G ++F+DH K TT+LDPRL
Sbjct: 295 LPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRL 326
Score = 41.2 bits (95), Expect = 5e-04
Identities = 22/52 (42%), Positives = 30/52 (57%), Gaps = 2/52 (3%)
Query: 13 DSED-ELPPGWEERTTKDGWVYYANHTEEKTQWEHP-KTGKRKRVAGDLPYG 62
D ED ELP GWE+ YY +H +KTQ+E+P + KRK+ G + G
Sbjct: 335 DCEDGELPYGWEKIEDPQYGTYYVDHLNQKTQFENPVEEAKRKKQLGQVEIG 386
>gi|239047795 pleckstrin homology domain containing, family A
member 7 [Homo sapiens]
Length = 1121
Score = 58.5 bits (140), Expect = 3e-09
Identities = 28/81 (34%), Positives = 39/81 (48%), Gaps = 4/81 (4%)
Query: 12 TDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGK----RKRVAGDLPYGWEQET 67
T D LP W +DG V++ N T W HP+TG+ + DLP GWE+
Sbjct: 5 TVGRDTLPEHWSYGVCRDGRVFFINDQLRCTTWLHPRTGEPVNSGHMIRSDLPRGWEEGF 64
Query: 68 DENGQVFFVDHINKRTTYLDP 88
E G +F+DH + T + P
Sbjct: 65 TEEGASYFIDHNQQTTAFRHP 85
Score = 40.8 bits (94), Expect = 7e-04
Identities = 15/35 (42%), Positives = 24/35 (68%)
Query: 17 ELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGK 51
+LP GWEE T++G Y+ +H ++ T + HP TG+
Sbjct: 55 DLPRGWEEGFTEEGASYFIDHNQQTTAFRHPVTGQ 89
Score = 27.3 bits (59), Expect = 8.0
Identities = 12/31 (38%), Positives = 18/31 (58%)
Query: 59 LPYGWEQETDENGQVFFVDHINKRTTYLDPR 89
LP W +G+VFF++ + TT+L PR
Sbjct: 11 LPEHWSYGVCRDGRVFFINDQLRCTTWLHPR 41
>gi|11141889 WW45 protein [Homo sapiens]
Length = 383
Score = 58.2 bits (139), Expect = 4e-09
Identities = 32/89 (35%), Positives = 40/89 (44%), Gaps = 7/89 (7%)
Query: 1 MAALRYAGLDDTDSED-ELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDL 59
+AA L + SED LPPGW T G YY +H T W HP + L
Sbjct: 183 VAATSLGNLTNHGSEDLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLERE------GL 236
Query: 60 PYGWEQETDENGQVFFVDHINKRTTYLDP 88
P GWE+ ++VDH NK+ Y P
Sbjct: 237 PPGWERVESSEFGTYYVDHTNKKAQYRHP 265
Score = 41.6 bits (96), Expect = 4e-04
Identities = 19/59 (32%), Positives = 27/59 (45%)
Query: 18 LPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFV 76
LPPGWE + + YY +HT +K Q+ HP R P ++ + E Q V
Sbjct: 236 LPPGWERVESSEFGTYYVDHTNKKAQYRHPCAPSVPRYDQPPPVTYQPQQTERNQSLLV 294
>gi|186928839 retinol dehydrogenase 12 [Homo sapiens]
Length = 316
Score = 54.3 bits (129), Expect = 6e-08
Identities = 29/73 (39%), Positives = 41/73 (56%), Gaps = 4/73 (5%)
Query: 101 PTTRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMAR 160
P+ R+ + G + GKVVV+TGAN+GIG ETA+ A GA V +ACR++ +
Sbjct: 20 PSIRKFFAGGVCRTNV----QLPGKVVVITGANTGIGKETARELASRGARVYIACRDVLK 75
Query: 161 ASEAVSRILEEWK 173
A S I + K
Sbjct: 76 GESAASEIRVDTK 88
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.133 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 8,374,293
Number of Sequences: 37866
Number of extensions: 355353
Number of successful extensions: 1107
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 127
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 780
Number of HSP's gapped (non-prelim): 280
length of query: 189
length of database: 18,247,518
effective HSP length: 96
effective length of query: 93
effective length of database: 14,612,382
effective search space: 1358951526
effective search space used: 1358951526
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 59 (27.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.