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Search of human proteins with 187937179
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|187937179 apoptosis-associated tyrosine kinase [Homo
sapiens]
(1374 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|187937179 apoptosis-associated tyrosine kinase [Homo sapiens] 2804 0.0
gi|122937267 lemur tyrosine kinase 3 [Homo sapiens] 623 e-178
gi|38016937 lemur tyrosine kinase 2 [Homo sapiens] 447 e-125
gi|239756966 PREDICTED: similar to arg tyrosine kinase [Homo sap... 212 2e-54
gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [... 172 3e-42
gi|22902130 PTK7 protein tyrosine kinase 7 isoform d precursor [... 172 3e-42
gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor [... 172 3e-42
gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor [... 172 3e-42
gi|119395738 insulin receptor isoform Short precursor [Homo sapi... 169 2e-41
gi|119395736 insulin receptor isoform Long precursor [Homo sapiens] 169 2e-41
gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isofo... 161 4e-39
gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isofo... 160 1e-38
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo... 157 7e-38
gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens] 154 4e-37
gi|29029632 anaplastic lymphoma kinase [Homo sapiens] 154 6e-37
gi|62420886 discoidin domain receptor family, member 2 precursor... 153 1e-36
gi|62420884 discoidin domain receptor family, member 2 precursor... 153 1e-36
gi|31657140 insulin receptor-related receptor precursor [Homo sa... 153 1e-36
gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isofo... 151 5e-36
gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isofor... 151 5e-36
gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isofo... 151 5e-36
gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precurs... 149 2e-35
gi|46249416 leukocyte receptor tyrosine kinase isoform 2 precurs... 149 2e-35
gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens] 148 4e-35
gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isofo... 144 4e-34
gi|21536468 AXL receptor tyrosine kinase isoform 2 [Homo sapiens] 142 2e-33
gi|21536466 AXL receptor tyrosine kinase isoform 1 [Homo sapiens] 142 2e-33
gi|66932918 MER receptor tyrosine kinase precursor [Homo sapiens] 140 8e-33
gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens] 136 1e-31
gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens] 136 1e-31
>gi|187937179 apoptosis-associated tyrosine kinase [Homo sapiens]
Length = 1374
Score = 2804 bits (7268), Expect = 0.0
Identities = 1374/1374 (100%), Positives = 1374/1374 (100%)
Query: 1 MSSSFFNPSFAFSSHFDPDGAPLSELSWPSSLAVVAVSFSGLFAVIVLMLACLCCKKGGI 60
MSSSFFNPSFAFSSHFDPDGAPLSELSWPSSLAVVAVSFSGLFAVIVLMLACLCCKKGGI
Sbjct: 1 MSSSFFNPSFAFSSHFDPDGAPLSELSWPSSLAVVAVSFSGLFAVIVLMLACLCCKKGGI 60
Query: 61 GFKEFENAEGDEYAADLAQGSPATAAQNGPDVYVLPLTEVSLPMAKQPGRSVQLLKSTDV 120
GFKEFENAEGDEYAADLAQGSPATAAQNGPDVYVLPLTEVSLPMAKQPGRSVQLLKSTDV
Sbjct: 61 GFKEFENAEGDEYAADLAQGSPATAAQNGPDVYVLPLTEVSLPMAKQPGRSVQLLKSTDV 120
Query: 121 GRHSLLYLKEIGRGWFGKVFLGEVNSGISSAQVVVKELQASASVQEQMQFLEEVQPYRAL 180
GRHSLLYLKEIGRGWFGKVFLGEVNSGISSAQVVVKELQASASVQEQMQFLEEVQPYRAL
Sbjct: 121 GRHSLLYLKEIGRGWFGKVFLGEVNSGISSAQVVVKELQASASVQEQMQFLEEVQPYRAL 180
Query: 181 KHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRSCRVAESMAPDPRTLQRMACEVACG 240
KHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRSCRVAESMAPDPRTLQRMACEVACG
Sbjct: 181 KHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRSCRVAESMAPDPRTLQRMACEVACG 240
Query: 241 VLHLHRNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYREDYFVTADQLWVPLRWIAPE 300
VLHLHRNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYREDYFVTADQLWVPLRWIAPE
Sbjct: 241 VLHLHRNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYREDYFVTADQLWVPLRWIAPE 300
Query: 301 LVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQVLAYTVREQQLKLPK 360
LVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQVLAYTVREQQLKLPK
Sbjct: 301 LVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQVLAYTVREQQLKLPK 360
Query: 361 PQLQLTLSDRWYEVMQFCWLQPEQRPTAEEVHLLLSYLCAKGATEAEEEFERRWRSLRPG 420
PQLQLTLSDRWYEVMQFCWLQPEQRPTAEEVHLLLSYLCAKGATEAEEEFERRWRSLRPG
Sbjct: 361 PQLQLTLSDRWYEVMQFCWLQPEQRPTAEEVHLLLSYLCAKGATEAEEEFERRWRSLRPG 420
Query: 421 GGGVGPGPGAAGPMLGGVVELAAASSFPLLEQFAGDGFHADGDDVLTVTETSRGLNFEYK 480
GGGVGPGPGAAGPMLGGVVELAAASSFPLLEQFAGDGFHADGDDVLTVTETSRGLNFEYK
Sbjct: 421 GGGVGPGPGAAGPMLGGVVELAAASSFPLLEQFAGDGFHADGDDVLTVTETSRGLNFEYK 480
Query: 481 WEAGRGAEAFPATLSPGRTARLQELCAPDGAPPGVVPVLSAHSPSLGSEYFIRLEEAAPA 540
WEAGRGAEAFPATLSPGRTARLQELCAPDGAPPGVVPVLSAHSPSLGSEYFIRLEEAAPA
Sbjct: 481 WEAGRGAEAFPATLSPGRTARLQELCAPDGAPPGVVPVLSAHSPSLGSEYFIRLEEAAPA 540
Query: 541 AGHDPDCAGCAPSPPATADQDDDSDGSTAASLAMEPLLGHGPPVDVPWGRGDHYPRRSLA 600
AGHDPDCAGCAPSPPATADQDDDSDGSTAASLAMEPLLGHGPPVDVPWGRGDHYPRRSLA
Sbjct: 541 AGHDPDCAGCAPSPPATADQDDDSDGSTAASLAMEPLLGHGPPVDVPWGRGDHYPRRSLA 600
Query: 601 RDPLCPSRSPSPSAGPLSLAEGGAEDADWGVAAFCPAFFEDPLGTSPLGSSGAPPLPLTG 660
RDPLCPSRSPSPSAGPLSLAEGGAEDADWGVAAFCPAFFEDPLGTSPLGSSGAPPLPLTG
Sbjct: 601 RDPLCPSRSPSPSAGPLSLAEGGAEDADWGVAAFCPAFFEDPLGTSPLGSSGAPPLPLTG 660
Query: 661 EDELEEVGARRAAQRGHWRSNVSANNNSGSRCPESWDPVSAGGHAEGCPSPKQTPRASPE 720
EDELEEVGARRAAQRGHWRSNVSANNNSGSRCPESWDPVSAGGHAEGCPSPKQTPRASPE
Sbjct: 661 EDELEEVGARRAAQRGHWRSNVSANNNSGSRCPESWDPVSAGGHAEGCPSPKQTPRASPE 720
Query: 721 PGYPGEPLLGLQAASAQEPGCCPGLPHLCSAQGLAPAPCLVTPSWTETASSGGDHPQAEP 780
PGYPGEPLLGLQAASAQEPGCCPGLPHLCSAQGLAPAPCLVTPSWTETASSGGDHPQAEP
Sbjct: 721 PGYPGEPLLGLQAASAQEPGCCPGLPHLCSAQGLAPAPCLVTPSWTETASSGGDHPQAEP 780
Query: 781 KLATEAEGTTGPRLPLPSVPSPSQEGAPLPSEEASAPDAPDALPDSPTPATGGEVSAIKL 840
KLATEAEGTTGPRLPLPSVPSPSQEGAPLPSEEASAPDAPDALPDSPTPATGGEVSAIKL
Sbjct: 781 KLATEAEGTTGPRLPLPSVPSPSQEGAPLPSEEASAPDAPDALPDSPTPATGGEVSAIKL 840
Query: 841 ASALNGSSSSPEVEAPSSEDEDTAEATSGIFTDTSSDGLQARRPDVVPAFRSLQKQVGTP 900
ASALNGSSSSPEVEAPSSEDEDTAEATSGIFTDTSSDGLQARRPDVVPAFRSLQKQVGTP
Sbjct: 841 ASALNGSSSSPEVEAPSSEDEDTAEATSGIFTDTSSDGLQARRPDVVPAFRSLQKQVGTP 900
Query: 901 DSLDSLDIPSSASDGGYEVFSPSATGPSGGQPRALDSGYDTENYESPEFVLKEAQEGCEP 960
DSLDSLDIPSSASDGGYEVFSPSATGPSGGQPRALDSGYDTENYESPEFVLKEAQEGCEP
Sbjct: 901 DSLDSLDIPSSASDGGYEVFSPSATGPSGGQPRALDSGYDTENYESPEFVLKEAQEGCEP 960
Query: 961 QAFAELASEGEGPGPETRLSTSLSGLNEKNPYRDSAYFSDLEAEAEATSGPEKKCGGDRA 1020
QAFAELASEGEGPGPETRLSTSLSGLNEKNPYRDSAYFSDLEAEAEATSGPEKKCGGDRA
Sbjct: 961 QAFAELASEGEGPGPETRLSTSLSGLNEKNPYRDSAYFSDLEAEAEATSGPEKKCGGDRA 1020
Query: 1021 PGPELGLPSTGQPSEQVCLRPGVSGEAQGSGPGEVLPPLLQLEGSSPEPSTCPSGLVPEP 1080
PGPELGLPSTGQPSEQVCLRPGVSGEAQGSGPGEVLPPLLQLEGSSPEPSTCPSGLVPEP
Sbjct: 1021 PGPELGLPSTGQPSEQVCLRPGVSGEAQGSGPGEVLPPLLQLEGSSPEPSTCPSGLVPEP 1080
Query: 1081 PEPQGPAKVRPGPSPSCSQFFLLTPVPLRSEGNSSEFQGPPGLLSGPAPQKRMGGPGTPR 1140
PEPQGPAKVRPGPSPSCSQFFLLTPVPLRSEGNSSEFQGPPGLLSGPAPQKRMGGPGTPR
Sbjct: 1081 PEPQGPAKVRPGPSPSCSQFFLLTPVPLRSEGNSSEFQGPPGLLSGPAPQKRMGGPGTPR 1140
Query: 1141 APLRLALPGLPAALEGRPEEEEEDSEDSDESDEELRCYSVQEPSEDSEEEAPAVPVVVAE 1200
APLRLALPGLPAALEGRPEEEEEDSEDSDESDEELRCYSVQEPSEDSEEEAPAVPVVVAE
Sbjct: 1141 APLRLALPGLPAALEGRPEEEEEDSEDSDESDEELRCYSVQEPSEDSEEEAPAVPVVVAE 1200
Query: 1201 SQSARNLRSLLKMPSLLSETFCEDLERKKKAVSFFDDVTVYLFDQESPTRELGEPFPGAK 1260
SQSARNLRSLLKMPSLLSETFCEDLERKKKAVSFFDDVTVYLFDQESPTRELGEPFPGAK
Sbjct: 1201 SQSARNLRSLLKMPSLLSETFCEDLERKKKAVSFFDDVTVYLFDQESPTRELGEPFPGAK 1260
Query: 1261 ESPPTFLRGSPGSPSAPNRPQQADGSPNGSTAEEGGGFAWDDDFPLMTAKAAFAMALDPA 1320
ESPPTFLRGSPGSPSAPNRPQQADGSPNGSTAEEGGGFAWDDDFPLMTAKAAFAMALDPA
Sbjct: 1261 ESPPTFLRGSPGSPSAPNRPQQADGSPNGSTAEEGGGFAWDDDFPLMTAKAAFAMALDPA 1320
Query: 1321 APAPAAPTPTPAPFSRFTVSPAPTSRFSITHVSDSDAESKRGPEAGAGGESKEA 1374
APAPAAPTPTPAPFSRFTVSPAPTSRFSITHVSDSDAESKRGPEAGAGGESKEA
Sbjct: 1321 APAPAAPTPTPAPFSRFTVSPAPTSRFSITHVSDSDAESKRGPEAGAGGESKEA 1374
>gi|122937267 lemur tyrosine kinase 3 [Homo sapiens]
Length = 1489
Score = 623 bits (1607), Expect = e-178
Identities = 528/1510 (34%), Positives = 686/1510 (45%), Gaps = 262/1510 (17%)
Query: 9 SFAFSSHFDPDGAPLSELSWPSSLAVVAVSFSGLFAVIVLMLACLCCKKGGIGFKEFENA 68
S +S PDG L AVV +S SGL A I L+L CLCCK+G +GFKEFEN
Sbjct: 45 SGCLASPAHPDGFALGRAPLAPPYAVVLISCSGLLAFIFLLLTCLCCKRGDVGFKEFENP 104
Query: 69 EGDEYAADLAQGSPATAA-QNGPDVYVLPLTEVSLPM-AKQPGRSVQLLKSTDVGRHSLL 126
EG++ + + + T++ Q+ PDVY+LPL EVSLPM A QP S + + R L
Sbjct: 105 EGEDCSGEYTPPAEETSSSQSLPDVYILPLAEVSLPMPAPQPSHS-DMTTPLGLSRQHLS 163
Query: 127 YLKEIGRGWFGKVFLGEVNSGISSAQVVVKELQASASVQEQMQFLEEVQPYRALKHSNLL 186
YL+EIG GWFGKV LGE+ S + AQVVVKEL+ASA EQ +F+ E QPYR+L+H N+L
Sbjct: 164 YLQEIGSGWFGKVILGEIFSDYTPAQVVVKELRASAGPLEQRKFISEAQPYRSLQHPNVL 223
Query: 187 QCLAQCAEVTPYLLVMEFCPLGDLKGYLRSCRVAESMAP-----DPRTLQRMACEVACGV 241
QCL C E P+LL+MEFC LGDLK YLR+ R E ++P D RTLQRM E+A G+
Sbjct: 224 QCLGLCVETLPFLLIMEFCQLGDLKRYLRAQRPPEGLSPELPPRDLRTLQRMGLEIARGL 283
Query: 242 LHLHRNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYREDYFVTADQLWVPLRWIAPEL 301
HLH +N+VHSDLALRNCLLT+DLTV+IGDYGLAH Y+EDY++T ++LW+PLRW APEL
Sbjct: 284 AHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYKEDYYLTPERLWIPLRWAAPEL 343
Query: 302 VDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQVLAYTVREQQLKLPKP 361
+ E+H +VVDQ++ N+WSLGVT+WELFE G QPY SD++VLA+ VR+Q +KL +P
Sbjct: 344 LGELHGTFMVVDQSRESNIWSLGVTLWELFEFGAQPYRHLSDEEVLAFVVRQQHVKLARP 403
Query: 362 QLQLTLSDRWYEVMQFCWLQPEQRPTAEEVHLLLSYLCAKGATEAEEEFERRWRSLRPGG 421
+L+L +D WY+++Q CW P QRP+A ++ L L+YL ++ P
Sbjct: 404 RLKLPYADYWYDILQSCWRPPAQRPSASDLQLQLTYLLSERPPRPPPP---------PPP 454
Query: 422 GGVGPGPGAAGPMLGGVVELAAASSFPLLEQFAGDGFHADGDDVLTVTETSRGLNFEYKW 481
GP P P +S FPLL+ F G AD DDVLTVTE+SRGLN E W
Sbjct: 455 PRDGPFPWPWPPAHSAPRPGTLSSPFPLLDGFPG----ADPDDVLTVTESSRGLNLECLW 510
Query: 482 E-----AGRGAEA---FPATLSPGRTARLQELCAPDGAPPGVVPVLSAHSPSLGSEYFIR 533
E AGRG A PA+ P A + P V+PV+SA SPS+ SEY+IR
Sbjct: 511 EKARRGAGRGGGAPAWQPASAPPAPHANPSNPFYEALSTPSVLPVISARSPSVSSEYYIR 570
Query: 534 LEEAAPAAGHDPDCAGCAPSPPATADQDDDSDGSTAASLAMEPLLGHGPPVDVPWGRGDH 593
LEE G P P D D G A P +VP +
Sbjct: 571 LEE-----------HGSPPEPLFPNDWDPLDPGVPAPQAPQ-------APSEVPQLVSET 612
Query: 594 YPRRSLARDPLCPSRSPSP----SAGPLSLAEGGAEDADWG-VAAFCPAFFEDPLGTSPL 648
+ PL P+ P P ++G L+ E G A PA GT+P
Sbjct: 613 W------ASPLFPAPRPFPAQSSASGSFLLSGWDPEGRGAGETLAGDPAEVLGERGTAPW 666
Query: 649 ------GSSGAPPLPLTGEDELEEVGARRAAQRGHWRSNVSANNNSGSRCP-ESWDPVSA 701
G+ P GED G ++RG + + + S P E D V+
Sbjct: 667 VEEEEEEEEGSSP----GEDSSSLGGG--PSRRGPLPCPLCSREGACSCLPLERGDAVAG 720
Query: 702 -GGH-AEGCPSPKQ--------------TPRASPEPGYPG--EPLLGLQAASAQEPG--- 740
GGH A GCP P + P A P P +PL+G AA+ Q PG
Sbjct: 721 WGGHPALGCPHPPEDDSSLRAERGSLADLPMAPPASAPPEFLDPLMG--AAAPQYPGRGP 778
Query: 741 -CCPGLPHLCSAQGLAPAPCLVTPSWTETASSGGDHPQAEP-KLATEAEGTTGPRLPLPS 798
P P PA PS + SG P +P E E P P
Sbjct: 779 PPAPPPPPPPPRAPADPAASPDPPSAVASPGSGLSSPGPKPGDSGYETETPFSPEGAFPG 838
Query: 799 VPSPSQEGAPLPSEEASAPD--APDALPD-SPTPATGG--------EVSAIKLASAL--- 844
+ +EG P P PD AP PD P P G +VS +L +L
Sbjct: 839 GGAAEEEGVPRPRAPPEPPDPGAPRPPPDPGPLPLPGPREKPTFVVQVSTEQLLMSLRED 898
Query: 845 --------NGSSSSPEVEAPSSEDEDTAEATSGIFTDTSSDGLQARRPDVVPAFRSLQKQ 896
G+++ + E G+ D + G + P SL
Sbjct: 899 VTRNLLGEKGATARETGPRKAGRGPGNREKVPGLNRDPTVLGNGKQAP-------SLSLP 951
Query: 897 VGTPDSLDSLD-----IPSSASDGG--------YEVFSPSATGPSGGQPRALDSGYDTEN 943
V L++ D I A++ G +V P + +AL++G + +
Sbjct: 952 VNGVTVLENGDQRAPGIEEKAAENGALGSPEREEKVLENGELTPPRREEKALENG-ELRS 1010
Query: 944 YESPEFVLKEAQEGCEPQAFAELASEGEG--------PGPETRLSTSLSGLNEKNP---- 991
E+ E VL G P + SE G PET G EK P
Sbjct: 1011 PEAGEKVL--VNGGLTPPKSEDKVSENGGLRFPRNTERPPETG-PWRAPGPWEKTPESWG 1067
Query: 992 ----YRDSAYFSDLEAEAEATSGPEKKCGGDRAPGP--------------ELGLPST-GQ 1032
+ A + LE ++ + GG+ APGP E P T G
Sbjct: 1068 PAPTIGEPAPETSLERAPAPSAVVSSRNGGETAPGPLGPAPKNGTLEPGTERRAPETGGA 1127
Query: 1033 PSEQVCLR---------PGVSGEAQGSGPGE-VLPPLLQLEGSSPEPSTCPSGLVPEPPE 1082
P R P +G A G GPG V ++ + P+P P +P PPE
Sbjct: 1128 PRAPGAGRLDLGSGGRAPVGTGTAPGGGPGSGVDAKAGWVDNTRPQPPPPP---LPPPPE 1184
Query: 1083 PQGPAKVRPGP--------------------------------------SPSCSQFFLLT 1104
Q P ++ P P P + FL
Sbjct: 1185 AQ-PRRLEPAPPRARPEVAPEGEPGAPDSRAGGDTALSGDGDPPKPERKGPEMPRLFLDL 1243
Query: 1105 PVPLRSEGNSSEFQGPPGLLSGPAPQKRM---GGPGTPRAPLRLA---LPGLPAALEGRP 1158
P +GNS + + LS P + GPG R P A G A G P
Sbjct: 1244 GPP---QGNSEQIKARLSRLSLALPPLTLTPFPGPGPRRPPWEGADAGAAGGEAGGAGAP 1300
Query: 1159 EEEEEDSEDSDESDEE----LRCYSVQEPSEDSEEEAPAVPVVV--AESQSARNLRSLLK 1212
EED ED DE +EE + P A VPVVV A++ +AR LR LLK
Sbjct: 1301 GPAEEDGEDEDEDEEEDEEAAAPGAAAGPRGPGRARAAPVPVVVSSADADAARPLRGLLK 1360
Query: 1213 MPSLLSETFCEDLERKKKAVSFFDDVTVYLFDQESPTRELGEPFPGAKESPPTFLRGSPG 1272
P E +LERK+K VSF DVTVYLFDQE+PT EL P ++ P+ P
Sbjct: 1361 SPRGADEPEDSELERKRKMVSFHGDVTVYLFDQETPTNELSVQAPPEGDTDPS---TPPA 1417
Query: 1273 SPSAPNRPQQADGSPNGSTAEEGGGFAWDDDFPLMTAKAAFAMALDPAAPAPAAPTPTPA 1332
P+ P+ DG P+ + GG F W +DFPL L P P P
Sbjct: 1418 PPTPPHPATPGDGFPSNDSG-FGGSFEWAEDFPL----------LPPPGP--------PL 1458
Query: 1333 PFSRFTVSPA 1342
FSRF+VSPA
Sbjct: 1459 CFSRFSVSPA 1468
>gi|38016937 lemur tyrosine kinase 2 [Homo sapiens]
Length = 1503
Score = 447 bits (1149), Expect = e-125
Identities = 262/585 (44%), Positives = 349/585 (59%), Gaps = 63/585 (10%)
Query: 19 DGAPLSELSWPSSLAVVAVSFSGLFAVIVLMLACL-CCKKGGIGFKEFENAEGDEYA-AD 76
+ P +E+S SS ++ V L +IVL+ C+ CCK I FKEFE+ DE
Sbjct: 36 EAPPAAEVS--SSFVILCVC--SLIILIVLIANCVSCCKDPEIDFKEFEDNFDDEIDFTP 91
Query: 77 LAQGSPATAAQNGPDVYVLPLTEVSLPMAKQPGRSVQLLKSTDVGRHSLLYLKEIGRGWF 136
A+ +P+ Q+ +V+ L + +SLP Q SV+ LKS V RHSL Y++EIG GWF
Sbjct: 92 PAEDTPSV--QSPAEVFTLSVPNISLPAPSQFQPSVEGLKS-QVARHSLNYIQEIGNGWF 148
Query: 137 GKVFLGEVNSGISSAQVVVKELQASASVQEQMQFLEEVQPYRALKHSNLLQCLAQCAEVT 196
GKV LGE+ +G S A+V+VKEL+ASA+ +EQ FL+ +PY L+H N+LQC+ QC E
Sbjct: 149 GKVLLGEIYTGTSVARVIVKELKASANPKEQDTFLKNGEPYYILQHPNILQCVGQCVEAI 208
Query: 197 PYLLVMEFCPLGDLKGYLRSCRVAESMAPDPRT--LQRMACEVACGVLHLHRNNFVHSDL 254
PYLLV EFC LGDLK YLRS + E M D +T LQRMACEVA G+ +H+ +F+HSDL
Sbjct: 209 PYLLVFEFCDLGDLKAYLRSEQ--EHMRGDSQTMLLQRMACEVAAGLAAMHKLHFLHSDL 266
Query: 255 ALRNCLLTADLTVKIGDYGLAHCKYREDYFVTADQLWVPLRWIAPELVDEVHSNLLVVDQ 314
ALRNC LT+DL VK+GDYG+ +Y+EDY T D+ PLRW APELV LL DQ
Sbjct: 267 ALRNCFLTSDLNVKVGDYGIGFSRYKEDYIETDDKKVFPLRWTAPELVTSFQDRLLTADQ 326
Query: 315 TKSGNVWSLGVTIWELFELGTQPYPQHSDQQVLAYTVREQQLKLPKPQLQLTLSDRWYEV 374
TK N+WSLGVT+WELF+ QPY S+ VL +RE+ KLPKPQL+ SDRWYEV
Sbjct: 327 TKYSNIWSLGVTLWELFDNAAQPYSNLSNLDVLNQVIRERDTKLPKPQLEQPYSDRWYEV 386
Query: 375 MQFCWLQPEQRPTAEEVHLLLSYLCAKGATEAEEEFERRWRSLRPGGGGVGPGPGAAGPM 434
+QFCWL PE+RP AE+VH LL+YL + ++E +FE++W +L+P AA
Sbjct: 387 LQFCWLSPEKRPAAEDVHRLLTYLRLQSQRDSEVDFEQQWNALKPNTNSRDSSNNAA--- 443
Query: 435 LGGVVELAAASSFPLLEQFAGDGFHADGDDVLTVTETSRGLNFEYKWEAGRG-------- 486
FP+L+ FA D + ++VLTVTETS+GL+FEY WEA +
Sbjct: 444 ------------FPILDHFARDRLGREMEEVLTVTETSQGLSFEYVWEAAKHDHFDERSR 491
Query: 487 ---------------AEAFPATLSPGRTARLQELCAPDGAP---PGVVPVLSAHSPSLGS 528
E F ++LS + + + P PGVVPV AH+ S+GS
Sbjct: 492 GHLDEGLSYTSIFYPVEVFESSLSDPGPGKQDD--SGQDVPLRVPGVVPVFDAHNLSVGS 549
Query: 529 EYFIRLEEAAPAAGHDPDCAGCAPSPPATADQDDDSDGSTAASLA 573
+Y+I+LEE +G + + PPA D D+ T L+
Sbjct: 550 DYYIQLEE---KSGSNLE----LDYPPALLTTDMDNPERTGPELS 587
Score = 200 bits (508), Expect = 9e-51
Identities = 184/599 (30%), Positives = 261/599 (43%), Gaps = 109/599 (18%)
Query: 835 VSAIKLASALNGSSSSPEVEAPSSEDEDTAEATSGIFTDTSSDGLQARRPDVVPAFRSLQ 894
+ A++ + LN ++ E S+ D+ S + D L A P P+
Sbjct: 944 LEAVETLNQLNSKDAAKEAGLVSALSSDSTSQDSLL-----EDSLSAPFPASEPSLE--- 995
Query: 895 KQVGTPDSLDSLDIPSSASDGGYEVFSPSATGPSGGQPRALDSGYDTENYESPEFVLKEA 954
TPDSL+S+D+ + D +P P + DSGY+TEN ESPE+ L A
Sbjct: 996 ----TPDSLESVDVHEALLDS-LGSHTPQKLVPPD---KPADSGYETENLESPEWTLHPA 1047
Query: 955 QEGC---EPQAFAELASEGEGPGPETRLSTSLSG------------LNEKNPYRDSAYFS 999
EG EP + G P P +S + G + YRDSAYFS
Sbjct: 1048 PEGTADSEPATTGDGGHSGLPPNPVIVISDAGDGHRGTEVTPETFTAGSQGSYRDSAYFS 1107
Query: 1000 DLEAEAEATS------GPEKKCGGDRAPGPELGLPSTGQPSEQVCLRPGVSGEAQGSGPG 1053
D ++E E S P P PE LP ++ CL EA+ S P
Sbjct: 1108 DNDSEPEKRSEEVPGTSPSALVLVQEQPLPEPVLPEQSPAAQDSCL------EARKSQPD 1161
Query: 1054 EVLPPLLQLEGSSPEPSTCPSGLVPEPPEPQGPAKVRPGPSPSCSQFFLLT--------- 1104
E L +T PEP + P +V P + S + +L
Sbjct: 1162 ESCLSALHNSSDLELRAT------PEPAQTGVPQQVHPTEDEASSPWSVLNAELSSGDDF 1215
Query: 1105 ------PVPLRSEG-NSSEFQGPPGLLSGPAPQKRMGGPGTPRAPL------RLALPGLP 1151
P L S G N++E + GP + +L + G+
Sbjct: 1216 ETQDDRPCTLASTGTNTNELLAYTNSALDKSLSSHSEGPKLKEPDIEGKYLGKLGVSGML 1275
Query: 1152 AALEGRPEEEEEDSEDSDESDEELRCYSVQEPSEDSEEEAPAVPVVVAESQSARNLRSLL 1211
E + +EED E+SD+SDE+LR +++ S +SE+E ++ ++ R+LRSLL
Sbjct: 1276 DLSEDGMDADEED-ENSDDSDEDLRAFNLHSLSSESEDETEHPVPIILSNEDGRHLRSLL 1334
Query: 1212 KMPSLLS-ETFCEDLERKKKAVSFFDDVTVYLFDQESPTRELGEPFPGAKESPPTFLRGS 1270
K + + + ED +++KKAV+FFDDVTVYLFDQE+PT+ELG P E+ L G
Sbjct: 1335 KPTAANAPDPLPEDWKKEKKAVTFFDDVTVYLFDQETPTKELG---PCGGEACGPDLSG- 1390
Query: 1271 PGSPSAPNRPQQADGSP--------NGSTAEEGGGFAWDDDF---PLMTAKAAFAMALDP 1319
P A GSP ST EEGGGF WDDDF P M+ + ++ P
Sbjct: 1391 ---------PAPASGSPYLSRCINSESSTDEEGGGFEWDDDFSPDPFMSKTTSNLLSSKP 1441
Query: 1320 --------AAPAPAAPT----PTPAPFSRFTVSPAPTSRFSITHVSDSDAESKRGPEAG 1366
+ P PA T P AP+SRF++SPA + FS+TH++DSD E E G
Sbjct: 1442 SLQTSKYFSPPPPARSTEQSWPHSAPYSRFSISPANIASFSLTHLTDSDIEQGGSSEDG 1500
Score = 36.2 bits (82), Expect = 0.22
Identities = 87/404 (21%), Positives = 138/404 (34%), Gaps = 64/404 (15%)
Query: 698 PVSAGGHAEGCPSPKQTPRASPEPGYPGEPLLGLQAASAQEPGCCPGLPHLCSAQGLAPA 757
P +G E SP+ T +PE EP G P + S G
Sbjct: 1027 PADSGYETENLESPEWTLHPAPEGTADSEP---ATTGDGGHSGLPPNPVIVISDAGDGHR 1083
Query: 758 PCLVTPSWTETASSGG---------DHPQAEPKLATEAEGTTGPRL------PLPSVPSP 802
VTP T TA S G D+ K + E GT+ L PLP P
Sbjct: 1084 GTEVTPE-TFTAGSQGSYRDSAYFSDNDSEPEKRSEEVPGTSPSALVLVQEQPLPEPVLP 1142
Query: 803 SQEGAPLPSEEASAPDAPDALPDSPTPATGGEVSAIKLASALNGSSSSPEVEAPSSEDED 862
Q P+ + S +A + PD + S ++L + + + + +EDE
Sbjct: 1143 EQS----PAAQDSCLEARKSQPDESCLSALHNSSDLELRATPEPAQTGVPQQVHPTEDEA 1198
Query: 863 T-------AEATSGIFTDTSSDGLQARRPDVVPAFRSLQKQVGTPDSLDSLDIPSSASDG 915
+ AE +SG +T D RP + + + ++ + +LD S+
Sbjct: 1199 SSPWSVLNAELSSGDDFETQDD-----RPCTLASTGTNTNEL-LAYTNSALDKSLSSHSE 1252
Query: 916 GYEVFSPSATGPSGGQ---PRALDSGYDTENYESPEFVLKEAQEGCEPQAFAELASEGEG 972
G ++ P G G+ LD D + + + ++ E L+SE E
Sbjct: 1253 GPKLKEPDIEGKYLGKLGVSGMLDLSEDGMDADEEDENSDDSDEDLRAFNLHSLSSESED 1312
Query: 973 -------------PGPETRLSTSLSGLNEKNPYRDS--------AYFSDLEAEAEATSGP 1011
G R + N +P + +F D+ P
Sbjct: 1313 ETEHPVPIILSNEDGRHLRSLLKPTAANAPDPLPEDWKKEKKAVTFFDDVTVYLFDQETP 1372
Query: 1012 EKKCG--GDRAPGPELG--LPSTGQPSEQVCLRPGVSGEAQGSG 1051
K+ G G A GP+L P++G P C+ S + +G G
Sbjct: 1373 TKELGPCGGEACGPDLSGPAPASGSPYLSRCINSESSTDEEGGG 1416
>gi|239756966 PREDICTED: similar to arg tyrosine kinase [Homo
sapiens]
Length = 243
Score = 212 bits (540), Expect = 2e-54
Identities = 102/102 (100%), Positives = 102/102 (100%)
Query: 168 MQFLEEVQPYRALKHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRSCRVAESMAPDP 227
MQFLEEVQPYRALKHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRSCRVAESMAPDP
Sbjct: 1 MQFLEEVQPYRALKHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRSCRVAESMAPDP 60
Query: 228 RTLQRMACEVACGVLHLHRNNFVHSDLALRNCLLTADLTVKI 269
RTLQRMACEVACGVLHLHRNNFVHSDLALRNCLLTADLTVKI
Sbjct: 61 RTLQRMACEVACGVLHLHRNNFVHSDLALRNCLLTADLTVKI 102
Score = 94.4 bits (233), Expect = 7e-19
Identities = 45/51 (88%), Positives = 47/51 (92%)
Query: 1311 AAFAMALDPAAPAPAAPTPTPAPFSRFTVSPAPTSRFSITHVSDSDAESKR 1361
A + +DPAAPAPAAPTPTPAPFSRFTVSPAPTSRFSITHVSDSDAESKR
Sbjct: 96 ADLTVKIDPAAPAPAAPTPTPAPFSRFTVSPAPTSRFSITHVSDSDAESKR 146
>gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [Homo
sapiens]
Length = 1070
Score = 172 bits (435), Expect = 3e-42
Identities = 119/373 (31%), Positives = 190/373 (50%), Gaps = 30/373 (8%)
Query: 32 LAVVAVSFSGLFAVIVLMLACLC-CKKGGIGFKEFENAEGDEYAADLAQGSPATAAQNGP 90
+ + +S A I+ +L + CKK + + EG+E + G P Q
Sbjct: 702 IQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSA 761
Query: 91 DVYVLPLTEVSLPMAKQPGRSVQLLKSTDVGRH----SLLYLKEIGRGWFGKVFLGE--- 143
++ EV+L + ST H SL + +G+ FG+VFL +
Sbjct: 762 EIQ----EEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQG 817
Query: 144 VNSGISSAQVVVKELQASASVQEQMQFLEEVQPYRALKHSNLLQCLAQCAEVTPYLLVME 203
+ G++ V+VK LQ S Q+Q+ F E++ + L H+N+++ L C E P+ +V+E
Sbjct: 818 LEEGVAETLVLVKSLQ-SKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLE 876
Query: 204 FCPLGDLKGYLRSCRVA-ESMAPDP-RTLQRMAC--EVACGVLHLHRNNFVHSDLALRNC 259
+ LGDLK +LR + E + P T Q++A +VA G+ HL N FVH DLA RNC
Sbjct: 877 YVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNC 936
Query: 260 LLTADLTVKIGDYGLAHCKYREDYFVTADQLWVPLRWIAPELVDEVHSNLLVVDQTKSGN 319
L++A VK+ GL+ Y +Y+ Q WVPLRW++PE + L D + +
Sbjct: 937 LVSAQRQVKVSALGLSKDVYNSEYY-HFRQAWVPLRWMSPEAI-------LEGDFSTKSD 988
Query: 320 VWSLGVTIWELFELGTQPYPQHSDQQVLAYTVREQQLKLPKPQLQLTLSDRWYEVMQFCW 379
VW+ GV +WE+F G P+ +D +VLA ++ + +LP+P+ + Y +MQ CW
Sbjct: 989 VWAFGVLMWEVFTHGEMPHGGQADDEVLA-DLQAGKARLPQPE---GCPSKLYRLMQRCW 1044
Query: 380 -LQPEQRPTAEEV 391
L P+ RP+ E+
Sbjct: 1045 ALSPKDRPSFSEI 1057
>gi|22902130 PTK7 protein tyrosine kinase 7 isoform d precursor [Homo
sapiens]
Length = 1014
Score = 172 bits (435), Expect = 3e-42
Identities = 119/373 (31%), Positives = 190/373 (50%), Gaps = 30/373 (8%)
Query: 32 LAVVAVSFSGLFAVIVLMLACLC-CKKGGIGFKEFENAEGDEYAADLAQGSPATAAQNGP 90
+ + +S A I+ +L + CKK + + EG+E + G P Q
Sbjct: 646 IQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSA 705
Query: 91 DVYVLPLTEVSLPMAKQPGRSVQLLKSTDVGRH----SLLYLKEIGRGWFGKVFLGE--- 143
++ EV+L + ST H SL + +G+ FG+VFL +
Sbjct: 706 EIQ----EEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQG 761
Query: 144 VNSGISSAQVVVKELQASASVQEQMQFLEEVQPYRALKHSNLLQCLAQCAEVTPYLLVME 203
+ G++ V+VK LQ S Q+Q+ F E++ + L H+N+++ L C E P+ +V+E
Sbjct: 762 LEEGVAETLVLVKSLQ-SKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLE 820
Query: 204 FCPLGDLKGYLRSCRVA-ESMAPDP-RTLQRMAC--EVACGVLHLHRNNFVHSDLALRNC 259
+ LGDLK +LR + E + P T Q++A +VA G+ HL N FVH DLA RNC
Sbjct: 821 YVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNC 880
Query: 260 LLTADLTVKIGDYGLAHCKYREDYFVTADQLWVPLRWIAPELVDEVHSNLLVVDQTKSGN 319
L++A VK+ GL+ Y +Y+ Q WVPLRW++PE + L D + +
Sbjct: 881 LVSAQRQVKVSALGLSKDVYNSEYY-HFRQAWVPLRWMSPEAI-------LEGDFSTKSD 932
Query: 320 VWSLGVTIWELFELGTQPYPQHSDQQVLAYTVREQQLKLPKPQLQLTLSDRWYEVMQFCW 379
VW+ GV +WE+F G P+ +D +VLA ++ + +LP+P+ + Y +MQ CW
Sbjct: 933 VWAFGVLMWEVFTHGEMPHGGQADDEVLA-DLQAGKARLPQPE---GCPSKLYRLMQRCW 988
Query: 380 -LQPEQRPTAEEV 391
L P+ RP+ E+
Sbjct: 989 ALSPKDRPSFSEI 1001
>gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor
[Homo sapiens]
Length = 940
Score = 172 bits (435), Expect = 3e-42
Identities = 119/373 (31%), Positives = 190/373 (50%), Gaps = 30/373 (8%)
Query: 32 LAVVAVSFSGLFAVIVLMLACLC-CKKGGIGFKEFENAEGDEYAADLAQGSPATAAQNGP 90
+ + +S A I+ +L + CKK + + EG+E + G P Q
Sbjct: 572 IQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSA 631
Query: 91 DVYVLPLTEVSLPMAKQPGRSVQLLKSTDVGRH----SLLYLKEIGRGWFGKVFLGE--- 143
++ EV+L + ST H SL + +G+ FG+VFL +
Sbjct: 632 EIQ----EEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQG 687
Query: 144 VNSGISSAQVVVKELQASASVQEQMQFLEEVQPYRALKHSNLLQCLAQCAEVTPYLLVME 203
+ G++ V+VK LQ S Q+Q+ F E++ + L H+N+++ L C E P+ +V+E
Sbjct: 688 LEEGVAETLVLVKSLQ-SKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLE 746
Query: 204 FCPLGDLKGYLRSCRVA-ESMAPDP-RTLQRMAC--EVACGVLHLHRNNFVHSDLALRNC 259
+ LGDLK +LR + E + P T Q++A +VA G+ HL N FVH DLA RNC
Sbjct: 747 YVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNC 806
Query: 260 LLTADLTVKIGDYGLAHCKYREDYFVTADQLWVPLRWIAPELVDEVHSNLLVVDQTKSGN 319
L++A VK+ GL+ Y +Y+ Q WVPLRW++PE + L D + +
Sbjct: 807 LVSAQRQVKVSALGLSKDVYNSEYY-HFRQAWVPLRWMSPEAI-------LEGDFSTKSD 858
Query: 320 VWSLGVTIWELFELGTQPYPQHSDQQVLAYTVREQQLKLPKPQLQLTLSDRWYEVMQFCW 379
VW+ GV +WE+F G P+ +D +VLA ++ + +LP+P+ + Y +MQ CW
Sbjct: 859 VWAFGVLMWEVFTHGEMPHGGQADDEVLA-DLQAGKARLPQPE---GCPSKLYRLMQRCW 914
Query: 380 -LQPEQRPTAEEV 391
L P+ RP+ E+
Sbjct: 915 ALSPKDRPSFSEI 927
>gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor [Homo
sapiens]
Length = 1030
Score = 172 bits (435), Expect = 3e-42
Identities = 119/373 (31%), Positives = 190/373 (50%), Gaps = 30/373 (8%)
Query: 32 LAVVAVSFSGLFAVIVLMLACLC-CKKGGIGFKEFENAEGDEYAADLAQGSPATAAQNGP 90
+ + +S A I+ +L + CKK + + EG+E + G P Q
Sbjct: 662 IQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSA 721
Query: 91 DVYVLPLTEVSLPMAKQPGRSVQLLKSTDVGRH----SLLYLKEIGRGWFGKVFLGE--- 143
++ EV+L + ST H SL + +G+ FG+VFL +
Sbjct: 722 EIQ----EEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQG 777
Query: 144 VNSGISSAQVVVKELQASASVQEQMQFLEEVQPYRALKHSNLLQCLAQCAEVTPYLLVME 203
+ G++ V+VK LQ S Q+Q+ F E++ + L H+N+++ L C E P+ +V+E
Sbjct: 778 LEEGVAETLVLVKSLQ-SKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLE 836
Query: 204 FCPLGDLKGYLRSCRVA-ESMAPDP-RTLQRMAC--EVACGVLHLHRNNFVHSDLALRNC 259
+ LGDLK +LR + E + P T Q++A +VA G+ HL N FVH DLA RNC
Sbjct: 837 YVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNC 896
Query: 260 LLTADLTVKIGDYGLAHCKYREDYFVTADQLWVPLRWIAPELVDEVHSNLLVVDQTKSGN 319
L++A VK+ GL+ Y +Y+ Q WVPLRW++PE + L D + +
Sbjct: 897 LVSAQRQVKVSALGLSKDVYNSEYY-HFRQAWVPLRWMSPEAI-------LEGDFSTKSD 948
Query: 320 VWSLGVTIWELFELGTQPYPQHSDQQVLAYTVREQQLKLPKPQLQLTLSDRWYEVMQFCW 379
VW+ GV +WE+F G P+ +D +VLA ++ + +LP+P+ + Y +MQ CW
Sbjct: 949 VWAFGVLMWEVFTHGEMPHGGQADDEVLA-DLQAGKARLPQPE---GCPSKLYRLMQRCW 1004
Query: 380 -LQPEQRPTAEEV 391
L P+ RP+ E+
Sbjct: 1005 ALSPKDRPSFSEI 1017
>gi|119395738 insulin receptor isoform Short precursor [Homo sapiens]
Length = 1370
Score = 169 bits (428), Expect = 2e-41
Identities = 107/295 (36%), Positives = 160/295 (54%), Gaps = 23/295 (7%)
Query: 111 SVQLLKSTDVGRHSLLYLKEIGRGWFGKVFLG---EVNSGISSAQVVVKELQASASVQEQ 167
SV + +V R + L+E+G+G FG V+ G ++ G + +V VK + SAS++E+
Sbjct: 997 SVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRER 1056
Query: 168 MQFLEEVQPYRALKHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRSCRVAESMAPD- 226
++FL E + ++++ L ++ P L+VME GDLK YLRS R P
Sbjct: 1057 IEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGR 1116
Query: 227 -PRTLQ---RMACEVACGVLHLHRNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYRED 282
P TLQ +MA E+A G+ +L+ FVH DLA RNC++ D TVKIGD+G+ Y D
Sbjct: 1117 PPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETD 1176
Query: 283 YFVTADQLWVPLRWIAPE-LVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQH 341
Y+ + +P+RW+APE L D V T S ++WS GV +WE+ L QPY
Sbjct: 1177 YYRKGGKGLLPVRWMAPESLKDGVF--------TTSSDMWSFGVVLWEITSLAEQPYQGL 1228
Query: 342 SDQQVLAYTVREQQLKLPKPQLQLTLSDRWYEVMQFCW-LQPEQRPTAEEVHLLL 395
S++QVL + + L P +R ++M+ CW P+ RPT E+ LL
Sbjct: 1229 SNEQVLKFVMDGGYLDQPD-----NCPERVTDLMRMCWQFNPKMRPTFLEIVNLL 1278
>gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]
Length = 1382
Score = 169 bits (428), Expect = 2e-41
Identities = 107/295 (36%), Positives = 160/295 (54%), Gaps = 23/295 (7%)
Query: 111 SVQLLKSTDVGRHSLLYLKEIGRGWFGKVFLG---EVNSGISSAQVVVKELQASASVQEQ 167
SV + +V R + L+E+G+G FG V+ G ++ G + +V VK + SAS++E+
Sbjct: 1009 SVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRER 1068
Query: 168 MQFLEEVQPYRALKHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRSCRVAESMAPD- 226
++FL E + ++++ L ++ P L+VME GDLK YLRS R P
Sbjct: 1069 IEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGR 1128
Query: 227 -PRTLQ---RMACEVACGVLHLHRNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYRED 282
P TLQ +MA E+A G+ +L+ FVH DLA RNC++ D TVKIGD+G+ Y D
Sbjct: 1129 PPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETD 1188
Query: 283 YFVTADQLWVPLRWIAPE-LVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQH 341
Y+ + +P+RW+APE L D V T S ++WS GV +WE+ L QPY
Sbjct: 1189 YYRKGGKGLLPVRWMAPESLKDGVF--------TTSSDMWSFGVVLWEITSLAEQPYQGL 1240
Query: 342 SDQQVLAYTVREQQLKLPKPQLQLTLSDRWYEVMQFCW-LQPEQRPTAEEVHLLL 395
S++QVL + + L P +R ++M+ CW P+ RPT E+ LL
Sbjct: 1241 SNEQVLKFVMDGGYLDQPD-----NCPERVTDLMRMCWQFNPKMRPTFLEIVNLL 1290
>gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isoform
c precursor [Homo sapiens]
Length = 822
Score = 161 bits (408), Expect = 4e-39
Identities = 118/394 (29%), Positives = 197/394 (50%), Gaps = 40/394 (10%)
Query: 30 SSLAVVAVSFSGLFAVIVLMLACLCCKKGGIGFKEFEN--AEGDEYAADL---AQGSPA- 83
S AVV ++ F ++V++ + G K + + D+ A+ L + GS
Sbjct: 432 SVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTP 491
Query: 84 TAAQNGPDVYVLPLTEVSLPMAKQPG----RSVQLLKST---DVGRHSLLYLKEIGRGWF 136
++++ GPD ++ +T++ P+ + P + QL T + RH+++ +E+G G F
Sbjct: 492 SSSEGGPDAVIIGMTKI--PVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAF 549
Query: 137 GKVFLGEVNSGISSAQ---VVVKELQASASVQEQMQFLEEVQPYRALKHSNLLQCLAQCA 193
GKVFL E + V VK L+ AS + F E + L+H ++++ C
Sbjct: 550 GKVFLAECYNLCPEQDKILVAVKTLK-DASDNARKDFHREAELLTNLQHEHIVKFYGVCV 608
Query: 194 EVTPYLLVMEFCPLGDLKGYLRS-----CRVAESMAPDPRTLQRM---ACEVACGVLHLH 245
E P ++V E+ GDL +LR+ +AE P T +M A ++A G+++L
Sbjct: 609 EGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLA 668
Query: 246 RNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYREDYFVTADQLWVPLRWIAPELVDEV 305
+FVH DLA RNCL+ +L VKIGD+G++ Y DY+ +P+RW+ PE
Sbjct: 669 SQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPE----- 723
Query: 306 HSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQVLAYTVREQQLKLPKPQLQL 365
+++ T +VWSLGV +WE+F G QP+ Q S+ +V+ + + L+ P+
Sbjct: 724 --SIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPR----- 776
Query: 366 TLSDRWYEVMQFCW-LQPEQRPTAEEVHLLLSYL 398
T YE+M CW +P R + +H LL L
Sbjct: 777 TCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNL 810
>gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isoform
a precursor [Homo sapiens]
Length = 838
Score = 160 bits (404), Expect = 1e-38
Identities = 120/410 (29%), Positives = 201/410 (49%), Gaps = 56/410 (13%)
Query: 30 SSLAVVAVSFSGLFAVIVLMLACLCCKKGGIGFKEF--------ENAEG----------D 71
S AVV ++ F ++V++ + G K+F ++ +G D
Sbjct: 432 SVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQGVGPASVISNDD 491
Query: 72 EYAADL---AQGSPA-TAAQNGPDVYVLPLTEVSLPMAKQPG----RSVQLLKST---DV 120
+ A+ L + GS ++++ GPD ++ +T++ P+ + P + QL T +
Sbjct: 492 DSASPLHHISNGSNTPSSSEGGPDAVIIGMTKI--PVIENPQYFGITNSQLKPDTFVQHI 549
Query: 121 GRHSLLYLKEIGRGWFGKVFLGEVNSGISSAQ---VVVKELQASASVQEQMQFLEEVQPY 177
RH+++ +E+G G FGKVFL E + V VK L+ AS + F E +
Sbjct: 550 KRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLK-DASDNARKDFHREAELL 608
Query: 178 RALKHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRS-----CRVAESMAPDPRTLQR 232
L+H ++++ C E P ++V E+ GDL +LR+ +AE P T +
Sbjct: 609 TNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQ 668
Query: 233 M---ACEVACGVLHLHRNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYREDYFVTADQ 289
M A ++A G+++L +FVH DLA RNCL+ +L VKIGD+G++ Y DY+
Sbjct: 669 MLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGH 728
Query: 290 LWVPLRWIAPELVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQVLAY 349
+P+RW+ PE +++ T +VWSLGV +WE+F G QP+ Q S+ +V+
Sbjct: 729 TMLPIRWMPPE-------SIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIEC 781
Query: 350 TVREQQLKLPKPQLQLTLSDRWYEVMQFCW-LQPEQRPTAEEVHLLLSYL 398
+ + L+ P+ T YE+M CW +P R + +H LL L
Sbjct: 782 ITQGRVLQRPR-----TCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNL 826
>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
sapiens]
Length = 1367
Score = 157 bits (397), Expect = 7e-38
Identities = 96/283 (33%), Positives = 150/283 (53%), Gaps = 23/283 (8%)
Query: 119 DVGRHSLLYLKEIGRGWFGKVFLGEVNSGISS---AQVVVKELQASASVQEQMQFLEEVQ 175
+V R + +E+G+G FG V+ G + +V +K + +AS++E+++FL E
Sbjct: 993 EVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEAS 1052
Query: 176 PYRALKHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRSCRVAESMAP--DPRTLQRM 233
+ ++++ L ++ P L++ME GDLK YLRS R P P +L +M
Sbjct: 1053 VMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKM 1112
Query: 234 ---ACEVACGVLHLHRNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYREDYFVTADQL 290
A E+A G+ +L+ N FVH DLA RNC++ D TVKIGD+G+ Y DY+ +
Sbjct: 1113 IQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKG 1172
Query: 291 WVPLRWIAPE-LVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQVLAY 349
+P+RW++PE L D V T +VWS GV +WE+ L QPY S++QVL +
Sbjct: 1173 LLPVRWMSPESLKDGVF--------TTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRF 1224
Query: 350 TVREQQLKLPKPQLQLTLSDRWYEVMQFCW-LQPEQRPTAEEV 391
+ L P D +E+M+ CW P+ RP+ E+
Sbjct: 1225 VMEGGLLDKPD-----NCPDMLFELMRMCWQYNPKMRPSFLEI 1262
>gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens]
Length = 2347
Score = 154 bits (390), Expect = 4e-37
Identities = 96/274 (35%), Positives = 144/274 (52%), Gaps = 26/274 (9%)
Query: 131 IGRGWFGKVFLGE----VNSGISSAQVVVKELQASASVQEQMQFLEEVQPYRALKHSNLL 186
+G G FG+V+ G + G +V VK L+ ++ QE+++FL+E H N+L
Sbjct: 1951 LGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNIL 2010
Query: 187 QCLAQCAEVTPYLLVMEFCPLGDLKGYLRSCRVAESMAP--DPRTLQRMACEVACGVLHL 244
+ L C P +++E GDL YLR R+A P L + +++ G ++L
Sbjct: 2011 KQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYL 2070
Query: 245 HRNNFVHSDLALRNCLL-----TADLTVKIGDYGLAHCKYREDYFVTADQLWVPLRWIAP 299
R +F+H DLA RNCL+ T+ VKIGD+GLA Y+ DY+ + +P+RW+AP
Sbjct: 2071 ERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAP 2130
Query: 300 E-LVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQVLAYTVREQQLKL 358
E L+D + T +VWS G+ IWE+ LG QPYP HS+ VL Y +L+
Sbjct: 2131 ESLMDGIF--------TTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEP 2182
Query: 359 PKPQLQLTLSDRWYEVMQFCWLQ-PEQRPTAEEV 391
P+ D + +M CW Q P+QRPT +
Sbjct: 2183 PR-----NCPDDLWNLMTQCWAQEPDQRPTFHRI 2211
>gi|29029632 anaplastic lymphoma kinase [Homo sapiens]
Length = 1620
Score = 154 bits (389), Expect = 6e-37
Identities = 93/287 (32%), Positives = 142/287 (49%), Gaps = 21/287 (7%)
Query: 109 GRSVQLLKSTDVGRHSLLYLKEIGRGWFGKVFLGEVN---SGISSAQVVVKELQASASVQ 165
G++ + +V R ++ ++ +G G FG+V+ G+V+ + S QV VK L S Q
Sbjct: 1100 GKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQ 1159
Query: 166 EQMQFLEEVQPYRALKHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRSCRVAESMAP 225
+++ FL E H N+++C+ + P +++E GDLK +LR R S
Sbjct: 1160 DELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPS 1219
Query: 226 DPRTLQ--RMACEVACGVLHLHRNNFVHSDLALRNCLLTAD---LTVKIGDYGLAHCKYR 280
L +A ++ACG +L N+F+H D+A RNCLLT KIGD+G+A YR
Sbjct: 1220 SLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYR 1279
Query: 281 EDYFVTADQLWVPLRWIAPELVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQ 340
Y+ +P++W+ PE E T + WS GV +WE+F LG PYP
Sbjct: 1280 ASYYRKGGCAMLPVKWMPPEAFMEGIF-------TSKTDTWSFGVLLWEIFSLGYMPYPS 1332
Query: 341 HSDQQVLAYTVREQQLKLPKPQLQLTLSDRWYEVMQFCWL-QPEQRP 386
S+Q+VL + ++ PK Y +M CW QPE RP
Sbjct: 1333 KSNQEVLEFVTSGGRMDPPK-----NCPGPVYRIMTQCWQHQPEDRP 1374
>gi|62420886 discoidin domain receptor family, member 2 precursor
[Homo sapiens]
Length = 855
Score = 153 bits (387), Expect = 1e-36
Identities = 108/319 (33%), Positives = 166/319 (52%), Gaps = 41/319 (12%)
Query: 108 PGRSVQLLKSTDVG-----RHSLLYLKEIGRGWFGKVFLGEVNS-----------GISSA 151
P ++ LL DV R L + +++G G FG+V L EV +S+
Sbjct: 541 PAVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSAN 600
Query: 152 Q---VVVKELQASASVQEQMQFLEEVQPYRALKHSNLLQCLAQCAEVTPYLLVMEFCPLG 208
Q V VK L+A A+ + FL+E++ LK N++ LA C P ++ E+ G
Sbjct: 601 QPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENG 660
Query: 209 DLKGYLRSCRVAESMAPDPRT-----LQRMACEVACGVLHLHRNNFVHSDLALRNCLLTA 263
DL +L S + D RT L+ MA ++A G+ +L NFVH DLA RNCL+
Sbjct: 661 DLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGK 720
Query: 264 DLTVKIGDYGLAHCKYREDYFVTADQLWVPLRWIAPELVDEVHSNLLVVDQTKSGNVWSL 323
+ T+KI D+G++ Y DY+ + +P+RW++ E ++L+ T + +VW+
Sbjct: 721 NYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWE-------SILLGKFTTASDVWAF 773
Query: 324 GVTIWELFEL-GTQPYPQHSDQQVLAYT---VREQ--QLKLPKPQLQLTLSDRWYEVMQF 377
GVT+WE F QPY Q SD+QV+ T R+Q Q LP+P + D Y++M
Sbjct: 774 GVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAI---CPDSVYKLMLS 830
Query: 378 CWLQ-PEQRPTAEEVHLLL 395
CW + + RP+ +E+HLLL
Sbjct: 831 CWRRDTKNRPSFQEIHLLL 849
>gi|62420884 discoidin domain receptor family, member 2 precursor
[Homo sapiens]
Length = 855
Score = 153 bits (387), Expect = 1e-36
Identities = 108/319 (33%), Positives = 166/319 (52%), Gaps = 41/319 (12%)
Query: 108 PGRSVQLLKSTDVG-----RHSLLYLKEIGRGWFGKVFLGEVNS-----------GISSA 151
P ++ LL DV R L + +++G G FG+V L EV +S+
Sbjct: 541 PAVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSAN 600
Query: 152 Q---VVVKELQASASVQEQMQFLEEVQPYRALKHSNLLQCLAQCAEVTPYLLVMEFCPLG 208
Q V VK L+A A+ + FL+E++ LK N++ LA C P ++ E+ G
Sbjct: 601 QPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENG 660
Query: 209 DLKGYLRSCRVAESMAPDPRT-----LQRMACEVACGVLHLHRNNFVHSDLALRNCLLTA 263
DL +L S + D RT L+ MA ++A G+ +L NFVH DLA RNCL+
Sbjct: 661 DLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGK 720
Query: 264 DLTVKIGDYGLAHCKYREDYFVTADQLWVPLRWIAPELVDEVHSNLLVVDQTKSGNVWSL 323
+ T+KI D+G++ Y DY+ + +P+RW++ E ++L+ T + +VW+
Sbjct: 721 NYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWE-------SILLGKFTTASDVWAF 773
Query: 324 GVTIWELFEL-GTQPYPQHSDQQVLAYT---VREQ--QLKLPKPQLQLTLSDRWYEVMQF 377
GVT+WE F QPY Q SD+QV+ T R+Q Q LP+P + D Y++M
Sbjct: 774 GVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAI---CPDSVYKLMLS 830
Query: 378 CWLQ-PEQRPTAEEVHLLL 395
CW + + RP+ +E+HLLL
Sbjct: 831 CWRRDTKNRPSFQEIHLLL 849
>gi|31657140 insulin receptor-related receptor precursor [Homo
sapiens]
Length = 1297
Score = 153 bits (386), Expect = 1e-36
Identities = 113/338 (33%), Positives = 172/338 (50%), Gaps = 45/338 (13%)
Query: 119 DVGRHSLLYLKEIGRGWFGKVFLG---EVNSGISSAQVVVKELQASASVQEQMQFLEEVQ 175
+V R + ++E+G+G FG V+ G + +G S V +K + AS +E ++FL+E
Sbjct: 973 EVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPRECIEFLKEAS 1032
Query: 176 PYRALKHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRSCRV-AESMAPDPRT----L 230
+A K ++++ L ++ P L++ME GDLK +LRS R AE+ P+ +
Sbjct: 1033 VMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAENNPGLPQPALGEM 1092
Query: 231 QRMACEVACGVLHLHRNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYREDYFVTADQL 290
+MA E+A G+ +L N FVH DLA RNC+++ D TVKIGD+G+ Y DY+ +
Sbjct: 1093 IQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKGGKG 1152
Query: 291 WVPLRWIAPE-LVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQVLAY 349
+P+RW+APE L D + T +VWS GV +WE+ L QPY S++QVL +
Sbjct: 1153 LLPVRWMAPESLKDGIF--------TTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKF 1204
Query: 350 TVREQQL-KLPKPQLQLTLSDRWYEVMQFCW----------------LQPEQRPTAEEVH 392
+ L +L LQL E+M CW +Q E RP+ +
Sbjct: 1205 VMDGGVLEELEGCPLQL------QELMSRCWQPNPRLRPSFTHILDSIQEELRPSFRLLS 1258
Query: 393 LLLSYLC--AKGA---TEAEEEFERRWRSLRPGGGGVG 425
S C A+G+ T+AE + R P GG G
Sbjct: 1259 FYYSPECRGARGSLPTTDAEPDSSPTPRDCSPQNGGPG 1296
>gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isoform
1 [Homo sapiens]
Length = 790
Score = 151 bits (381), Expect = 5e-36
Identities = 96/293 (32%), Positives = 152/293 (51%), Gaps = 27/293 (9%)
Query: 120 VGRHSLLYLKEIGRGWFGKVFLGEVNSGISSAQ---VVVKELQASASVQEQMQFLEEVQP 176
+ R ++ E+G G FGKVFL E ++ + V VK L+ AS + F E +
Sbjct: 499 IKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK-EASESARQDFQREAEL 557
Query: 177 YRALKHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRS-------CRVAESMAPDPRT 229
L+H ++++ C E P L+V E+ GDL +LRS E +AP P
Sbjct: 558 LTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLG 617
Query: 230 LQRM---ACEVACGVLHLHRNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYREDYFVT 286
L ++ A +VA G+++L +FVH DLA RNCL+ L VKIGD+G++ Y DY+
Sbjct: 618 LGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRV 677
Query: 287 ADQLWVPLRWIAPELVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQV 346
+ +P+RW+ PE ++L T +VWS GV +WE+F G QP+ Q S+ +
Sbjct: 678 GGRTMLPIRWMPPE-------SILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEA 730
Query: 347 LAYTVREQQLKLPKPQLQLTLSDRWYEVMQFCW-LQPEQRPTAEEVHLLLSYL 398
+ + ++L+ P+ Y +M+ CW +P+QR + ++VH L L
Sbjct: 731 IDCITQGRELERPR-----ACPPEVYAIMRGCWQREPQQRHSIKDVHARLQAL 778
>gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isoform 2
[Homo sapiens]
Length = 796
Score = 151 bits (381), Expect = 5e-36
Identities = 96/293 (32%), Positives = 152/293 (51%), Gaps = 27/293 (9%)
Query: 120 VGRHSLLYLKEIGRGWFGKVFLGEVNSGISSAQ---VVVKELQASASVQEQMQFLEEVQP 176
+ R ++ E+G G FGKVFL E ++ + V VK L+ AS + F E +
Sbjct: 505 IKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK-EASESARQDFQREAEL 563
Query: 177 YRALKHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRS-------CRVAESMAPDPRT 229
L+H ++++ C E P L+V E+ GDL +LRS E +AP P
Sbjct: 564 LTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLG 623
Query: 230 LQRM---ACEVACGVLHLHRNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYREDYFVT 286
L ++ A +VA G+++L +FVH DLA RNCL+ L VKIGD+G++ Y DY+
Sbjct: 624 LGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRV 683
Query: 287 ADQLWVPLRWIAPELVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQV 346
+ +P+RW+ PE ++L T +VWS GV +WE+F G QP+ Q S+ +
Sbjct: 684 GGRTMLPIRWMPPE-------SILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEA 736
Query: 347 LAYTVREQQLKLPKPQLQLTLSDRWYEVMQFCW-LQPEQRPTAEEVHLLLSYL 398
+ + ++L+ P+ Y +M+ CW +P+QR + ++VH L L
Sbjct: 737 IDCITQGRELERPR-----ACPPEVYAIMRGCWQREPQQRHSIKDVHARLQAL 784
>gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isoform
3 [Homo sapiens]
Length = 760
Score = 151 bits (381), Expect = 5e-36
Identities = 96/293 (32%), Positives = 152/293 (51%), Gaps = 27/293 (9%)
Query: 120 VGRHSLLYLKEIGRGWFGKVFLGEVNSGISSAQ---VVVKELQASASVQEQMQFLEEVQP 176
+ R ++ E+G G FGKVFL E ++ + V VK L+ AS + F E +
Sbjct: 469 IKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK-EASESARQDFQREAEL 527
Query: 177 YRALKHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRS-------CRVAESMAPDPRT 229
L+H ++++ C E P L+V E+ GDL +LRS E +AP P
Sbjct: 528 LTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLG 587
Query: 230 LQRM---ACEVACGVLHLHRNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYREDYFVT 286
L ++ A +VA G+++L +FVH DLA RNCL+ L VKIGD+G++ Y DY+
Sbjct: 588 LGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRV 647
Query: 287 ADQLWVPLRWIAPELVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQV 346
+ +P+RW+ PE ++L T +VWS GV +WE+F G QP+ Q S+ +
Sbjct: 648 GGRTMLPIRWMPPE-------SILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEA 700
Query: 347 LAYTVREQQLKLPKPQLQLTLSDRWYEVMQFCW-LQPEQRPTAEEVHLLLSYL 398
+ + ++L+ P+ Y +M+ CW +P+QR + ++VH L L
Sbjct: 701 IDCITQGRELERPR-----ACPPEVYAIMRGCWQREPQQRHSIKDVHARLQAL 748
>gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precursor
[Homo sapiens]
Length = 864
Score = 149 bits (376), Expect = 2e-35
Identities = 95/290 (32%), Positives = 148/290 (51%), Gaps = 23/290 (7%)
Query: 118 TDVGRHSLLYLKEIGRGWFGKVFLGEV---NSGISSAQVVVKELQASASVQEQMQFLEEV 174
T+V ++ L+ +G G FG+V+ G V S QV +K L S Q+++ FL E
Sbjct: 503 TEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEA 562
Query: 175 QPYRALKHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRSCRVAESMAPDP---RTLQ 231
+H N+++C+ TP L+++E GD+K +LR R P P R L
Sbjct: 563 LIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSR-PHLGQPSPLVMRDLL 621
Query: 232 RMACEVACGVLHLHRNNFVHSDLALRNCLLTA---DLTVKIGDYGLAHCKYREDYFVTAD 288
++A ++A G +L N+F+H D+A RNCLL+ KIGD+G+A YR Y+ D
Sbjct: 622 QLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGD 681
Query: 289 QLWVPLRWIAPELVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQVLA 348
+ +P++W+ PE E + +T S WS GV +WE+F LG PYP ++Q+VL
Sbjct: 682 RALLPVKWMPPEAFLEG----IFTSKTDS---WSFGVLLWEIFSLGYMPYPGRTNQEVLD 734
Query: 349 YTVREQQLKLPKPQLQLTLSDRWYEVMQFCWL-QPEQRPTAEEVHLLLSY 397
+ V ++ P+ Y +M CW +PE RP+ + L Y
Sbjct: 735 FVVGGGRMDPPR-----GCPGPVYRIMTQCWQHEPELRPSFASILERLQY 779
>gi|46249416 leukocyte receptor tyrosine kinase isoform 2 precursor
[Homo sapiens]
Length = 803
Score = 149 bits (376), Expect = 2e-35
Identities = 95/290 (32%), Positives = 148/290 (51%), Gaps = 23/290 (7%)
Query: 118 TDVGRHSLLYLKEIGRGWFGKVFLGEV---NSGISSAQVVVKELQASASVQEQMQFLEEV 174
T+V ++ L+ +G G FG+V+ G V S QV +K L S Q+++ FL E
Sbjct: 442 TEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEA 501
Query: 175 QPYRALKHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRSCRVAESMAPDP---RTLQ 231
+H N+++C+ TP L+++E GD+K +LR R P P R L
Sbjct: 502 LIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSR-PHLGQPSPLVMRDLL 560
Query: 232 RMACEVACGVLHLHRNNFVHSDLALRNCLLTA---DLTVKIGDYGLAHCKYREDYFVTAD 288
++A ++A G +L N+F+H D+A RNCLL+ KIGD+G+A YR Y+ D
Sbjct: 561 QLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGD 620
Query: 289 QLWVPLRWIAPELVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQVLA 348
+ +P++W+ PE E + +T S WS GV +WE+F LG PYP ++Q+VL
Sbjct: 621 RALLPVKWMPPEAFLEG----IFTSKTDS---WSFGVLLWEIFSLGYMPYPGRTNQEVLD 673
Query: 349 YTVREQQLKLPKPQLQLTLSDRWYEVMQFCWL-QPEQRPTAEEVHLLLSY 397
+ V ++ P+ Y +M CW +PE RP+ + L Y
Sbjct: 674 FVVGGGRMDPPR-----GCPGPVYRIMTQCWQHEPELRPSFASILERLQY 718
>gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens]
Length = 869
Score = 148 bits (373), Expect = 4e-35
Identities = 108/398 (27%), Positives = 174/398 (43%), Gaps = 50/398 (12%)
Query: 29 PSSLAVVAVSFSGLFAVIVLML--ACLCCKKGGIGFKEFENAEGDEYAADLAQGSPATAA 86
P+ V +S FA+ VL+ CC++ K+++N + + A L
Sbjct: 490 PTYSMTVIISIMSSFAIFVLLTITTLYCCRRR----KQWKNKKRESAAVTLT-------- 537
Query: 87 QNGPDVYVLPLTEVSLPMAKQPGRSVQLLKSTDVGRHSLLYLKEIGRGWFGKVFLGEVNS 146
P +L + + P L S + R+++ Y+++IG G FG+VF
Sbjct: 538 -TLPSELLLDRLHPNPMYQRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPG 596
Query: 147 GISS---AQVVVKELQASASVQEQMQFLEEVQPYRALKHSNLLQCLAQCAEVTPYLLVME 203
+ V VK L+ AS Q F E + N+++ L CA P L+ E
Sbjct: 597 LLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFE 656
Query: 204 FCPLGDLKGYLRS------CRVAES----------MAPDPRTLQRMAC---EVACGVLHL 244
+ GDL +LRS C ++ S P P + C +VA G+ +L
Sbjct: 657 YMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYL 716
Query: 245 HRNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYREDYFVTADQLWVPLRWIAPELVDE 304
FVH DLA RNCL+ ++ VKI D+GL+ Y DY+ + +P+RW+ PE
Sbjct: 717 SERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPE---- 772
Query: 305 VHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQVLAYTVREQQLKLPKPQLQ 364
++ T +VW+ GV +WE+F G QPY + ++V+ Y L P+
Sbjct: 773 ---SIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPE---- 825
Query: 365 LTLSDRWYEVMQFCWLQ-PEQRPTAEEVHLLLSYLCAK 401
Y +M+ CW + P RP+ +H +L +C +
Sbjct: 826 -NCPVELYNLMRLCWSKLPADRPSFTSIHRILERMCER 862
>gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isoform
b precursor [Homo sapiens]
Length = 825
Score = 144 bits (364), Expect = 4e-34
Identities = 105/393 (26%), Positives = 186/393 (47%), Gaps = 37/393 (9%)
Query: 31 SLAVVAVSFSGLFAVIVLMLACLCCKKGGIGFK-EFENAEGDEYAAD----LAQG-SPAT 84
S+AV +F+ + V++ ++ ++ G K G+E +A + G + +
Sbjct: 433 SIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPS 492
Query: 85 AAQNGPDVYVLPLTEVSLPMAKQPGRSVQLLKSTD-----VGRHSLLYLKEIGRGWFGKV 139
+ GPD V+ +T + + Q R D + R ++ +E+G G FGKV
Sbjct: 493 SLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKV 552
Query: 140 FLGEVN--SGISSAQVVVKELQASASVQEQMQFLEEVQPYRALKHSNLLQCLAQCAEVTP 197
FL E S +V + ++ + F E + L+H ++++ C + P
Sbjct: 553 FLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDP 612
Query: 198 YLLVMEFCPLGDLKGYLRSCRVAESMAPDPRTLQ-----------RMACEVACGVLHLHR 246
++V E+ GDL +LR+ + D + Q +A ++A G+++L
Sbjct: 613 LIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLAS 672
Query: 247 NNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYREDYFVTADQLWVPLRWIAPELVDEVH 306
+FVH DLA RNCL+ A+L VKIGD+G++ Y DY+ +P+RW+ PE
Sbjct: 673 QHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPE------ 726
Query: 307 SNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQVLAYTVREQQLKLPKPQLQLT 366
+++ T +VWS GV +WE+F G QP+ Q S+ +V+ + + L+ P+
Sbjct: 727 -SIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPR-----V 780
Query: 367 LSDRWYEVMQFCW-LQPEQRPTAEEVHLLLSYL 398
Y+VM CW +P+QR +E++ +L L
Sbjct: 781 CPKEVYDVMLGCWQREPQQRLNIKEIYKILHAL 813
>gi|21536468 AXL receptor tyrosine kinase isoform 2 [Homo sapiens]
Length = 885
Score = 142 bits (358), Expect = 2e-33
Identities = 99/328 (30%), Positives = 161/328 (49%), Gaps = 25/328 (7%)
Query: 115 LKSTDVGRHSLLYLKEIGRGWFGKVFLGEVNSGISSAQVVVKELQASASVQEQMQ-FLEE 173
L+ V RH + K +G G FG V G++N S +V VK ++ + + +++ FL E
Sbjct: 517 LRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSE 576
Query: 174 VQPYRALKHSNLLQCLAQCAEVTPY------LLVMEFCPLGDLKGYLRSCRVAESMAPDP 227
+ H N+++ + C + + ++++ F GDL +L R+ + P
Sbjct: 577 AVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLP 636
Query: 228 -RTLQRMACEVACGVLHLHRNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYREDYFVT 286
+ L + ++A G+ +L F+H DLA RNC+L +++V + D+GL+ Y DY+
Sbjct: 637 TQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQ 696
Query: 287 ADQLWVPLRWIAPE-LVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQ 345
+P++WIA E L D V+ T +VWS GVT+WE+ G PYP + +
Sbjct: 697 GRIAKMPVKWIAIESLADRVY--------TSKSDVWSFGVTMWEIATRGQTPYPGVENSE 748
Query: 346 VLAYTVREQQLKLPKPQLQLTLSDRWYEVMQFCW-LQPEQRPTAEEVHLLLSYLCAKGAT 404
+ Y + +LK P L D Y +M CW L P+ RP+ E+ L K
Sbjct: 749 IYDYLRQGNRLKQPADCL-----DGLYALMSRCWELNPQDRPSFTELREDLEN-TLKALP 802
Query: 405 EAEEEFERRWRSLRPGGGGVGPGPGAAG 432
A+E E + ++ GGG P PGAAG
Sbjct: 803 PAQEPDEILYVNMDEGGGYPEP-PGAAG 829
>gi|21536466 AXL receptor tyrosine kinase isoform 1 [Homo sapiens]
Length = 894
Score = 142 bits (358), Expect = 2e-33
Identities = 99/328 (30%), Positives = 161/328 (49%), Gaps = 25/328 (7%)
Query: 115 LKSTDVGRHSLLYLKEIGRGWFGKVFLGEVNSGISSAQVVVKELQASASVQEQMQ-FLEE 173
L+ V RH + K +G G FG V G++N S +V VK ++ + + +++ FL E
Sbjct: 526 LRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSE 585
Query: 174 VQPYRALKHSNLLQCLAQCAEVTPY------LLVMEFCPLGDLKGYLRSCRVAESMAPDP 227
+ H N+++ + C + + ++++ F GDL +L R+ + P
Sbjct: 586 AVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLP 645
Query: 228 -RTLQRMACEVACGVLHLHRNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYREDYFVT 286
+ L + ++A G+ +L F+H DLA RNC+L +++V + D+GL+ Y DY+
Sbjct: 646 TQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQ 705
Query: 287 ADQLWVPLRWIAPE-LVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQ 345
+P++WIA E L D V+ T +VWS GVT+WE+ G PYP + +
Sbjct: 706 GRIAKMPVKWIAIESLADRVY--------TSKSDVWSFGVTMWEIATRGQTPYPGVENSE 757
Query: 346 VLAYTVREQQLKLPKPQLQLTLSDRWYEVMQFCW-LQPEQRPTAEEVHLLLSYLCAKGAT 404
+ Y + +LK P L D Y +M CW L P+ RP+ E+ L K
Sbjct: 758 IYDYLRQGNRLKQPADCL-----DGLYALMSRCWELNPQDRPSFTELREDLEN-TLKALP 811
Query: 405 EAEEEFERRWRSLRPGGGGVGPGPGAAG 432
A+E E + ++ GGG P PGAAG
Sbjct: 812 PAQEPDEILYVNMDEGGGYPEP-PGAAG 838
>gi|66932918 MER receptor tyrosine kinase precursor [Homo sapiens]
Length = 999
Score = 140 bits (353), Expect = 8e-33
Identities = 94/294 (31%), Positives = 147/294 (50%), Gaps = 23/294 (7%)
Query: 115 LKSTDVGRHSLLYLKEIGRGWFGKVFLGEVNSGI-SSAQVVVKELQASASVQEQMQ-FLE 172
L+ + R+ L+ K +G G FG V G + +S +V VK ++ S Q +++ FL
Sbjct: 577 LEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLS 636
Query: 173 EVQPYRALKHSNLLQCLAQCAEVTPY-----LLVMEFCPLGDLKGYLRSCRVAESMAPDP 227
E + H N+++ L C E++ ++++ F GDL YL R+ P
Sbjct: 637 EAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIP 696
Query: 228 -RTLQRMACEVACGVLHLHRNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYREDYFVT 286
+TL + ++A G+ +L NF+H DLA RNC+L D+TV + D+GL+ Y DY+
Sbjct: 697 LQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQ 756
Query: 287 ADQLWVPLRWIAPE-LVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQ 345
+P++WIA E L D V+ T +VW+ GVT+WE+ G PYP + +
Sbjct: 757 GRIAKMPVKWIAIESLADRVY--------TSKSDVWAFGVTMWEIATRGMTPYPGVQNHE 808
Query: 346 VLAYTVREQQLKLPKPQLQLTLSDRWYEVMQFCW-LQPEQRPTAEEVHLLLSYL 398
+ Y + +LK P+ L D YE+M CW P RPT + L L L
Sbjct: 809 MYDYLLHGHRLKQPEDCL-----DELYEIMYSCWRTDPLDRPTFSVLRLQLEKL 857
>gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens]
Length = 675
Score = 136 bits (343), Expect = 1e-31
Identities = 88/274 (32%), Positives = 138/274 (50%), Gaps = 23/274 (8%)
Query: 119 DVGRHSLLYLKEIGRGWFGKVFLGEVNSGISSAQVVVKELQASASVQEQMQFLEEVQPYR 178
++ R + LKE+G G FG V LG+ A ++KE S+ E +F +E Q
Sbjct: 411 ELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKE----GSMSED-EFFQEAQTMM 465
Query: 179 ALKHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRSCRVAESMAPDPRTLQRMACEVA 238
L H L++ C++ P +V E+ G L YLRS +P L M +V
Sbjct: 466 KLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRS----HGKGLEPSQLLEMCYDVC 521
Query: 239 CGVLHLHRNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYREDYFVTADQLWVPLRWIA 298
G+ L + F+H DLA RNCL+ DL VK+ D+G+ +D +V++ P++W A
Sbjct: 522 EGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTR-YVLDDQYVSSVGTKFPVKWSA 580
Query: 299 PELVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQVLAYTVREQQLKL 358
PE+ + +VW+ G+ +WE+F LG QPY + + QV+ Q +L
Sbjct: 581 PEVFH-------YFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKV--SQGHRL 631
Query: 359 PKPQLQLTLSDRWYEVMQFCWLQ-PEQRPTAEEV 391
+P L SD Y++M CW + PE+RPT +++
Sbjct: 632 YRPHL---ASDTIYQIMYSCWHELPEKRPTFQQL 662
>gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens]
Length = 675
Score = 136 bits (343), Expect = 1e-31
Identities = 88/274 (32%), Positives = 138/274 (50%), Gaps = 23/274 (8%)
Query: 119 DVGRHSLLYLKEIGRGWFGKVFLGEVNSGISSAQVVVKELQASASVQEQMQFLEEVQPYR 178
++ R + LKE+G G FG V LG+ A ++KE S+ E +F +E Q
Sbjct: 411 ELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKE----GSMSED-EFFQEAQTMM 465
Query: 179 ALKHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRSCRVAESMAPDPRTLQRMACEVA 238
L H L++ C++ P +V E+ G L YLRS +P L M +V
Sbjct: 466 KLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRS----HGKGLEPSQLLEMCYDVC 521
Query: 239 CGVLHLHRNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYREDYFVTADQLWVPLRWIA 298
G+ L + F+H DLA RNCL+ DL VK+ D+G+ +D +V++ P++W A
Sbjct: 522 EGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTR-YVLDDQYVSSVGTKFPVKWSA 580
Query: 299 PELVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQVLAYTVREQQLKL 358
PE+ + +VW+ G+ +WE+F LG QPY + + QV+ Q +L
Sbjct: 581 PEVFH-------YFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKV--SQGHRL 631
Query: 359 PKPQLQLTLSDRWYEVMQFCWLQ-PEQRPTAEEV 391
+P L SD Y++M CW + PE+RPT +++
Sbjct: 632 YRPHL---ASDTIYQIMYSCWHELPEKRPTFQQL 662
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.131 0.399
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 70,503,318
Number of Sequences: 37866
Number of extensions: 4607023
Number of successful extensions: 39721
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 611
Number of HSP's successfully gapped in prelim test: 1721
Number of HSP's that attempted gapping in prelim test: 23730
Number of HSP's gapped (non-prelim): 13397
length of query: 1374
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1259
effective length of database: 13,892,928
effective search space: 17491196352
effective search space used: 17491196352
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.