Guide to the Human Genome
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Search of human proteins with 187937179

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|187937179 apoptosis-associated tyrosine kinase [Homo
sapiens]
         (1374 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|187937179 apoptosis-associated tyrosine kinase [Homo sapiens]     2804   0.0  
gi|122937267 lemur tyrosine kinase 3 [Homo sapiens]                   623   e-178
gi|38016937 lemur tyrosine kinase 2 [Homo sapiens]                    447   e-125
gi|239756966 PREDICTED: similar to arg tyrosine kinase [Homo sap...   212   2e-54
gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [...   172   3e-42
gi|22902130 PTK7 protein tyrosine kinase 7 isoform d precursor [...   172   3e-42
gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor [...   172   3e-42
gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor [...   172   3e-42
gi|119395738 insulin receptor isoform Short precursor [Homo sapi...   169   2e-41
gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]   169   2e-41
gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isofo...   161   4e-39
gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isofo...   160   1e-38
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo...   157   7e-38
gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens]   154   4e-37
gi|29029632 anaplastic lymphoma kinase [Homo sapiens]                 154   6e-37
gi|62420886 discoidin domain receptor family, member 2 precursor...   153   1e-36
gi|62420884 discoidin domain receptor family, member 2 precursor...   153   1e-36
gi|31657140 insulin receptor-related receptor precursor [Homo sa...   153   1e-36
gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isofo...   151   5e-36
gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isofor...   151   5e-36
gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isofo...   151   5e-36
gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precurs...   149   2e-35
gi|46249416 leukocyte receptor tyrosine kinase isoform 2 precurs...   149   2e-35
gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens]    148   4e-35
gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isofo...   144   4e-34
gi|21536468 AXL receptor tyrosine kinase isoform 2 [Homo sapiens]     142   2e-33
gi|21536466 AXL receptor tyrosine kinase isoform 1 [Homo sapiens]     142   2e-33
gi|66932918 MER receptor tyrosine kinase precursor [Homo sapiens]     140   8e-33
gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens]            136   1e-31
gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens]           136   1e-31

>gi|187937179 apoptosis-associated tyrosine kinase [Homo sapiens]
          Length = 1374

 Score = 2804 bits (7268), Expect = 0.0
 Identities = 1374/1374 (100%), Positives = 1374/1374 (100%)

Query: 1    MSSSFFNPSFAFSSHFDPDGAPLSELSWPSSLAVVAVSFSGLFAVIVLMLACLCCKKGGI 60
            MSSSFFNPSFAFSSHFDPDGAPLSELSWPSSLAVVAVSFSGLFAVIVLMLACLCCKKGGI
Sbjct: 1    MSSSFFNPSFAFSSHFDPDGAPLSELSWPSSLAVVAVSFSGLFAVIVLMLACLCCKKGGI 60

Query: 61   GFKEFENAEGDEYAADLAQGSPATAAQNGPDVYVLPLTEVSLPMAKQPGRSVQLLKSTDV 120
            GFKEFENAEGDEYAADLAQGSPATAAQNGPDVYVLPLTEVSLPMAKQPGRSVQLLKSTDV
Sbjct: 61   GFKEFENAEGDEYAADLAQGSPATAAQNGPDVYVLPLTEVSLPMAKQPGRSVQLLKSTDV 120

Query: 121  GRHSLLYLKEIGRGWFGKVFLGEVNSGISSAQVVVKELQASASVQEQMQFLEEVQPYRAL 180
            GRHSLLYLKEIGRGWFGKVFLGEVNSGISSAQVVVKELQASASVQEQMQFLEEVQPYRAL
Sbjct: 121  GRHSLLYLKEIGRGWFGKVFLGEVNSGISSAQVVVKELQASASVQEQMQFLEEVQPYRAL 180

Query: 181  KHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRSCRVAESMAPDPRTLQRMACEVACG 240
            KHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRSCRVAESMAPDPRTLQRMACEVACG
Sbjct: 181  KHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRSCRVAESMAPDPRTLQRMACEVACG 240

Query: 241  VLHLHRNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYREDYFVTADQLWVPLRWIAPE 300
            VLHLHRNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYREDYFVTADQLWVPLRWIAPE
Sbjct: 241  VLHLHRNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYREDYFVTADQLWVPLRWIAPE 300

Query: 301  LVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQVLAYTVREQQLKLPK 360
            LVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQVLAYTVREQQLKLPK
Sbjct: 301  LVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQVLAYTVREQQLKLPK 360

Query: 361  PQLQLTLSDRWYEVMQFCWLQPEQRPTAEEVHLLLSYLCAKGATEAEEEFERRWRSLRPG 420
            PQLQLTLSDRWYEVMQFCWLQPEQRPTAEEVHLLLSYLCAKGATEAEEEFERRWRSLRPG
Sbjct: 361  PQLQLTLSDRWYEVMQFCWLQPEQRPTAEEVHLLLSYLCAKGATEAEEEFERRWRSLRPG 420

Query: 421  GGGVGPGPGAAGPMLGGVVELAAASSFPLLEQFAGDGFHADGDDVLTVTETSRGLNFEYK 480
            GGGVGPGPGAAGPMLGGVVELAAASSFPLLEQFAGDGFHADGDDVLTVTETSRGLNFEYK
Sbjct: 421  GGGVGPGPGAAGPMLGGVVELAAASSFPLLEQFAGDGFHADGDDVLTVTETSRGLNFEYK 480

Query: 481  WEAGRGAEAFPATLSPGRTARLQELCAPDGAPPGVVPVLSAHSPSLGSEYFIRLEEAAPA 540
            WEAGRGAEAFPATLSPGRTARLQELCAPDGAPPGVVPVLSAHSPSLGSEYFIRLEEAAPA
Sbjct: 481  WEAGRGAEAFPATLSPGRTARLQELCAPDGAPPGVVPVLSAHSPSLGSEYFIRLEEAAPA 540

Query: 541  AGHDPDCAGCAPSPPATADQDDDSDGSTAASLAMEPLLGHGPPVDVPWGRGDHYPRRSLA 600
            AGHDPDCAGCAPSPPATADQDDDSDGSTAASLAMEPLLGHGPPVDVPWGRGDHYPRRSLA
Sbjct: 541  AGHDPDCAGCAPSPPATADQDDDSDGSTAASLAMEPLLGHGPPVDVPWGRGDHYPRRSLA 600

Query: 601  RDPLCPSRSPSPSAGPLSLAEGGAEDADWGVAAFCPAFFEDPLGTSPLGSSGAPPLPLTG 660
            RDPLCPSRSPSPSAGPLSLAEGGAEDADWGVAAFCPAFFEDPLGTSPLGSSGAPPLPLTG
Sbjct: 601  RDPLCPSRSPSPSAGPLSLAEGGAEDADWGVAAFCPAFFEDPLGTSPLGSSGAPPLPLTG 660

Query: 661  EDELEEVGARRAAQRGHWRSNVSANNNSGSRCPESWDPVSAGGHAEGCPSPKQTPRASPE 720
            EDELEEVGARRAAQRGHWRSNVSANNNSGSRCPESWDPVSAGGHAEGCPSPKQTPRASPE
Sbjct: 661  EDELEEVGARRAAQRGHWRSNVSANNNSGSRCPESWDPVSAGGHAEGCPSPKQTPRASPE 720

Query: 721  PGYPGEPLLGLQAASAQEPGCCPGLPHLCSAQGLAPAPCLVTPSWTETASSGGDHPQAEP 780
            PGYPGEPLLGLQAASAQEPGCCPGLPHLCSAQGLAPAPCLVTPSWTETASSGGDHPQAEP
Sbjct: 721  PGYPGEPLLGLQAASAQEPGCCPGLPHLCSAQGLAPAPCLVTPSWTETASSGGDHPQAEP 780

Query: 781  KLATEAEGTTGPRLPLPSVPSPSQEGAPLPSEEASAPDAPDALPDSPTPATGGEVSAIKL 840
            KLATEAEGTTGPRLPLPSVPSPSQEGAPLPSEEASAPDAPDALPDSPTPATGGEVSAIKL
Sbjct: 781  KLATEAEGTTGPRLPLPSVPSPSQEGAPLPSEEASAPDAPDALPDSPTPATGGEVSAIKL 840

Query: 841  ASALNGSSSSPEVEAPSSEDEDTAEATSGIFTDTSSDGLQARRPDVVPAFRSLQKQVGTP 900
            ASALNGSSSSPEVEAPSSEDEDTAEATSGIFTDTSSDGLQARRPDVVPAFRSLQKQVGTP
Sbjct: 841  ASALNGSSSSPEVEAPSSEDEDTAEATSGIFTDTSSDGLQARRPDVVPAFRSLQKQVGTP 900

Query: 901  DSLDSLDIPSSASDGGYEVFSPSATGPSGGQPRALDSGYDTENYESPEFVLKEAQEGCEP 960
            DSLDSLDIPSSASDGGYEVFSPSATGPSGGQPRALDSGYDTENYESPEFVLKEAQEGCEP
Sbjct: 901  DSLDSLDIPSSASDGGYEVFSPSATGPSGGQPRALDSGYDTENYESPEFVLKEAQEGCEP 960

Query: 961  QAFAELASEGEGPGPETRLSTSLSGLNEKNPYRDSAYFSDLEAEAEATSGPEKKCGGDRA 1020
            QAFAELASEGEGPGPETRLSTSLSGLNEKNPYRDSAYFSDLEAEAEATSGPEKKCGGDRA
Sbjct: 961  QAFAELASEGEGPGPETRLSTSLSGLNEKNPYRDSAYFSDLEAEAEATSGPEKKCGGDRA 1020

Query: 1021 PGPELGLPSTGQPSEQVCLRPGVSGEAQGSGPGEVLPPLLQLEGSSPEPSTCPSGLVPEP 1080
            PGPELGLPSTGQPSEQVCLRPGVSGEAQGSGPGEVLPPLLQLEGSSPEPSTCPSGLVPEP
Sbjct: 1021 PGPELGLPSTGQPSEQVCLRPGVSGEAQGSGPGEVLPPLLQLEGSSPEPSTCPSGLVPEP 1080

Query: 1081 PEPQGPAKVRPGPSPSCSQFFLLTPVPLRSEGNSSEFQGPPGLLSGPAPQKRMGGPGTPR 1140
            PEPQGPAKVRPGPSPSCSQFFLLTPVPLRSEGNSSEFQGPPGLLSGPAPQKRMGGPGTPR
Sbjct: 1081 PEPQGPAKVRPGPSPSCSQFFLLTPVPLRSEGNSSEFQGPPGLLSGPAPQKRMGGPGTPR 1140

Query: 1141 APLRLALPGLPAALEGRPEEEEEDSEDSDESDEELRCYSVQEPSEDSEEEAPAVPVVVAE 1200
            APLRLALPGLPAALEGRPEEEEEDSEDSDESDEELRCYSVQEPSEDSEEEAPAVPVVVAE
Sbjct: 1141 APLRLALPGLPAALEGRPEEEEEDSEDSDESDEELRCYSVQEPSEDSEEEAPAVPVVVAE 1200

Query: 1201 SQSARNLRSLLKMPSLLSETFCEDLERKKKAVSFFDDVTVYLFDQESPTRELGEPFPGAK 1260
            SQSARNLRSLLKMPSLLSETFCEDLERKKKAVSFFDDVTVYLFDQESPTRELGEPFPGAK
Sbjct: 1201 SQSARNLRSLLKMPSLLSETFCEDLERKKKAVSFFDDVTVYLFDQESPTRELGEPFPGAK 1260

Query: 1261 ESPPTFLRGSPGSPSAPNRPQQADGSPNGSTAEEGGGFAWDDDFPLMTAKAAFAMALDPA 1320
            ESPPTFLRGSPGSPSAPNRPQQADGSPNGSTAEEGGGFAWDDDFPLMTAKAAFAMALDPA
Sbjct: 1261 ESPPTFLRGSPGSPSAPNRPQQADGSPNGSTAEEGGGFAWDDDFPLMTAKAAFAMALDPA 1320

Query: 1321 APAPAAPTPTPAPFSRFTVSPAPTSRFSITHVSDSDAESKRGPEAGAGGESKEA 1374
            APAPAAPTPTPAPFSRFTVSPAPTSRFSITHVSDSDAESKRGPEAGAGGESKEA
Sbjct: 1321 APAPAAPTPTPAPFSRFTVSPAPTSRFSITHVSDSDAESKRGPEAGAGGESKEA 1374


>gi|122937267 lemur tyrosine kinase 3 [Homo sapiens]
          Length = 1489

 Score =  623 bits (1607), Expect = e-178
 Identities = 528/1510 (34%), Positives = 686/1510 (45%), Gaps = 262/1510 (17%)

Query: 9    SFAFSSHFDPDGAPLSELSWPSSLAVVAVSFSGLFAVIVLMLACLCCKKGGIGFKEFENA 68
            S   +S   PDG  L         AVV +S SGL A I L+L CLCCK+G +GFKEFEN 
Sbjct: 45   SGCLASPAHPDGFALGRAPLAPPYAVVLISCSGLLAFIFLLLTCLCCKRGDVGFKEFENP 104

Query: 69   EGDEYAADLAQGSPATAA-QNGPDVYVLPLTEVSLPM-AKQPGRSVQLLKSTDVGRHSLL 126
            EG++ + +    +  T++ Q+ PDVY+LPL EVSLPM A QP  S  +     + R  L 
Sbjct: 105  EGEDCSGEYTPPAEETSSSQSLPDVYILPLAEVSLPMPAPQPSHS-DMTTPLGLSRQHLS 163

Query: 127  YLKEIGRGWFGKVFLGEVNSGISSAQVVVKELQASASVQEQMQFLEEVQPYRALKHSNLL 186
            YL+EIG GWFGKV LGE+ S  + AQVVVKEL+ASA   EQ +F+ E QPYR+L+H N+L
Sbjct: 164  YLQEIGSGWFGKVILGEIFSDYTPAQVVVKELRASAGPLEQRKFISEAQPYRSLQHPNVL 223

Query: 187  QCLAQCAEVTPYLLVMEFCPLGDLKGYLRSCRVAESMAP-----DPRTLQRMACEVACGV 241
            QCL  C E  P+LL+MEFC LGDLK YLR+ R  E ++P     D RTLQRM  E+A G+
Sbjct: 224  QCLGLCVETLPFLLIMEFCQLGDLKRYLRAQRPPEGLSPELPPRDLRTLQRMGLEIARGL 283

Query: 242  LHLHRNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYREDYFVTADQLWVPLRWIAPEL 301
             HLH +N+VHSDLALRNCLLT+DLTV+IGDYGLAH  Y+EDY++T ++LW+PLRW APEL
Sbjct: 284  AHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYKEDYYLTPERLWIPLRWAAPEL 343

Query: 302  VDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQVLAYTVREQQLKLPKP 361
            + E+H   +VVDQ++  N+WSLGVT+WELFE G QPY   SD++VLA+ VR+Q +KL +P
Sbjct: 344  LGELHGTFMVVDQSRESNIWSLGVTLWELFEFGAQPYRHLSDEEVLAFVVRQQHVKLARP 403

Query: 362  QLQLTLSDRWYEVMQFCWLQPEQRPTAEEVHLLLSYLCAKGATEAEEEFERRWRSLRPGG 421
            +L+L  +D WY+++Q CW  P QRP+A ++ L L+YL ++                 P  
Sbjct: 404  RLKLPYADYWYDILQSCWRPPAQRPSASDLQLQLTYLLSERPPRPPPP---------PPP 454

Query: 422  GGVGPGPGAAGPMLGGVVELAAASSFPLLEQFAGDGFHADGDDVLTVTETSRGLNFEYKW 481
               GP P    P          +S FPLL+ F G    AD DDVLTVTE+SRGLN E  W
Sbjct: 455  PRDGPFPWPWPPAHSAPRPGTLSSPFPLLDGFPG----ADPDDVLTVTESSRGLNLECLW 510

Query: 482  E-----AGRGAEA---FPATLSPGRTARLQELCAPDGAPPGVVPVLSAHSPSLGSEYFIR 533
            E     AGRG  A    PA+  P   A          + P V+PV+SA SPS+ SEY+IR
Sbjct: 511  EKARRGAGRGGGAPAWQPASAPPAPHANPSNPFYEALSTPSVLPVISARSPSVSSEYYIR 570

Query: 534  LEEAAPAAGHDPDCAGCAPSPPATADQDDDSDGSTAASLAMEPLLGHGPPVDVPWGRGDH 593
            LEE            G  P P    D D    G  A             P +VP    + 
Sbjct: 571  LEE-----------HGSPPEPLFPNDWDPLDPGVPAPQAPQ-------APSEVPQLVSET 612

Query: 594  YPRRSLARDPLCPSRSPSP----SAGPLSLAEGGAEDADWG-VAAFCPAFFEDPLGTSPL 648
            +        PL P+  P P    ++G   L+    E    G   A  PA      GT+P 
Sbjct: 613  W------ASPLFPAPRPFPAQSSASGSFLLSGWDPEGRGAGETLAGDPAEVLGERGTAPW 666

Query: 649  ------GSSGAPPLPLTGEDELEEVGARRAAQRGHWRSNVSANNNSGSRCP-ESWDPVSA 701
                     G+ P    GED     G    ++RG     + +   + S  P E  D V+ 
Sbjct: 667  VEEEEEEEEGSSP----GEDSSSLGGG--PSRRGPLPCPLCSREGACSCLPLERGDAVAG 720

Query: 702  -GGH-AEGCPSPKQ--------------TPRASPEPGYPG--EPLLGLQAASAQEPG--- 740
             GGH A GCP P +               P A P    P   +PL+G  AA+ Q PG   
Sbjct: 721  WGGHPALGCPHPPEDDSSLRAERGSLADLPMAPPASAPPEFLDPLMG--AAAPQYPGRGP 778

Query: 741  -CCPGLPHLCSAQGLAPAPCLVTPSWTETASSGGDHPQAEP-KLATEAEGTTGPRLPLPS 798
               P  P         PA     PS   +  SG   P  +P     E E    P    P 
Sbjct: 779  PPAPPPPPPPPRAPADPAASPDPPSAVASPGSGLSSPGPKPGDSGYETETPFSPEGAFPG 838

Query: 799  VPSPSQEGAPLPSEEASAPD--APDALPD-SPTPATGG--------EVSAIKLASAL--- 844
              +  +EG P P      PD  AP   PD  P P  G         +VS  +L  +L   
Sbjct: 839  GGAAEEEGVPRPRAPPEPPDPGAPRPPPDPGPLPLPGPREKPTFVVQVSTEQLLMSLRED 898

Query: 845  --------NGSSSSPEVEAPSSEDEDTAEATSGIFTDTSSDGLQARRPDVVPAFRSLQKQ 896
                     G+++       +       E   G+  D +  G   + P       SL   
Sbjct: 899  VTRNLLGEKGATARETGPRKAGRGPGNREKVPGLNRDPTVLGNGKQAP-------SLSLP 951

Query: 897  VGTPDSLDSLD-----IPSSASDGG--------YEVFSPSATGPSGGQPRALDSGYDTEN 943
            V     L++ D     I   A++ G         +V       P   + +AL++G +  +
Sbjct: 952  VNGVTVLENGDQRAPGIEEKAAENGALGSPEREEKVLENGELTPPRREEKALENG-ELRS 1010

Query: 944  YESPEFVLKEAQEGCEPQAFAELASEGEG--------PGPETRLSTSLSGLNEKNP---- 991
             E+ E VL     G  P    +  SE  G          PET       G  EK P    
Sbjct: 1011 PEAGEKVL--VNGGLTPPKSEDKVSENGGLRFPRNTERPPETG-PWRAPGPWEKTPESWG 1067

Query: 992  ----YRDSAYFSDLEAEAEATSGPEKKCGGDRAPGP--------------ELGLPST-GQ 1032
                  + A  + LE     ++    + GG+ APGP              E   P T G 
Sbjct: 1068 PAPTIGEPAPETSLERAPAPSAVVSSRNGGETAPGPLGPAPKNGTLEPGTERRAPETGGA 1127

Query: 1033 PSEQVCLR---------PGVSGEAQGSGPGE-VLPPLLQLEGSSPEPSTCPSGLVPEPPE 1082
            P      R         P  +G A G GPG  V      ++ + P+P   P   +P PPE
Sbjct: 1128 PRAPGAGRLDLGSGGRAPVGTGTAPGGGPGSGVDAKAGWVDNTRPQPPPPP---LPPPPE 1184

Query: 1083 PQGPAKVRPGP--------------------------------------SPSCSQFFLLT 1104
             Q P ++ P P                                       P   + FL  
Sbjct: 1185 AQ-PRRLEPAPPRARPEVAPEGEPGAPDSRAGGDTALSGDGDPPKPERKGPEMPRLFLDL 1243

Query: 1105 PVPLRSEGNSSEFQGPPGLLSGPAPQKRM---GGPGTPRAPLRLA---LPGLPAALEGRP 1158
              P   +GNS + +     LS   P   +    GPG  R P   A     G  A   G P
Sbjct: 1244 GPP---QGNSEQIKARLSRLSLALPPLTLTPFPGPGPRRPPWEGADAGAAGGEAGGAGAP 1300

Query: 1159 EEEEEDSEDSDESDEE----LRCYSVQEPSEDSEEEAPAVPVVV--AESQSARNLRSLLK 1212
               EED ED DE +EE        +   P       A  VPVVV  A++ +AR LR LLK
Sbjct: 1301 GPAEEDGEDEDEDEEEDEEAAAPGAAAGPRGPGRARAAPVPVVVSSADADAARPLRGLLK 1360

Query: 1213 MPSLLSETFCEDLERKKKAVSFFDDVTVYLFDQESPTRELGEPFPGAKESPPTFLRGSPG 1272
             P    E    +LERK+K VSF  DVTVYLFDQE+PT EL    P   ++ P+     P 
Sbjct: 1361 SPRGADEPEDSELERKRKMVSFHGDVTVYLFDQETPTNELSVQAPPEGDTDPS---TPPA 1417

Query: 1273 SPSAPNRPQQADGSPNGSTAEEGGGFAWDDDFPLMTAKAAFAMALDPAAPAPAAPTPTPA 1332
             P+ P+     DG P+  +   GG F W +DFPL          L P  P        P 
Sbjct: 1418 PPTPPHPATPGDGFPSNDSG-FGGSFEWAEDFPL----------LPPPGP--------PL 1458

Query: 1333 PFSRFTVSPA 1342
             FSRF+VSPA
Sbjct: 1459 CFSRFSVSPA 1468


>gi|38016937 lemur tyrosine kinase 2 [Homo sapiens]
          Length = 1503

 Score =  447 bits (1149), Expect = e-125
 Identities = 262/585 (44%), Positives = 349/585 (59%), Gaps = 63/585 (10%)

Query: 19  DGAPLSELSWPSSLAVVAVSFSGLFAVIVLMLACL-CCKKGGIGFKEFENAEGDEYA-AD 76
           +  P +E+S  SS  ++ V    L  +IVL+  C+ CCK   I FKEFE+   DE     
Sbjct: 36  EAPPAAEVS--SSFVILCVC--SLIILIVLIANCVSCCKDPEIDFKEFEDNFDDEIDFTP 91

Query: 77  LAQGSPATAAQNGPDVYVLPLTEVSLPMAKQPGRSVQLLKSTDVGRHSLLYLKEIGRGWF 136
            A+ +P+   Q+  +V+ L +  +SLP   Q   SV+ LKS  V RHSL Y++EIG GWF
Sbjct: 92  PAEDTPSV--QSPAEVFTLSVPNISLPAPSQFQPSVEGLKS-QVARHSLNYIQEIGNGWF 148

Query: 137 GKVFLGEVNSGISSAQVVVKELQASASVQEQMQFLEEVQPYRALKHSNLLQCLAQCAEVT 196
           GKV LGE+ +G S A+V+VKEL+ASA+ +EQ  FL+  +PY  L+H N+LQC+ QC E  
Sbjct: 149 GKVLLGEIYTGTSVARVIVKELKASANPKEQDTFLKNGEPYYILQHPNILQCVGQCVEAI 208

Query: 197 PYLLVMEFCPLGDLKGYLRSCRVAESMAPDPRT--LQRMACEVACGVLHLHRNNFVHSDL 254
           PYLLV EFC LGDLK YLRS +  E M  D +T  LQRMACEVA G+  +H+ +F+HSDL
Sbjct: 209 PYLLVFEFCDLGDLKAYLRSEQ--EHMRGDSQTMLLQRMACEVAAGLAAMHKLHFLHSDL 266

Query: 255 ALRNCLLTADLTVKIGDYGLAHCKYREDYFVTADQLWVPLRWIAPELVDEVHSNLLVVDQ 314
           ALRNC LT+DL VK+GDYG+   +Y+EDY  T D+   PLRW APELV      LL  DQ
Sbjct: 267 ALRNCFLTSDLNVKVGDYGIGFSRYKEDYIETDDKKVFPLRWTAPELVTSFQDRLLTADQ 326

Query: 315 TKSGNVWSLGVTIWELFELGTQPYPQHSDQQVLAYTVREQQLKLPKPQLQLTLSDRWYEV 374
           TK  N+WSLGVT+WELF+   QPY   S+  VL   +RE+  KLPKPQL+   SDRWYEV
Sbjct: 327 TKYSNIWSLGVTLWELFDNAAQPYSNLSNLDVLNQVIRERDTKLPKPQLEQPYSDRWYEV 386

Query: 375 MQFCWLQPEQRPTAEEVHLLLSYLCAKGATEAEEEFERRWRSLRPGGGGVGPGPGAAGPM 434
           +QFCWL PE+RP AE+VH LL+YL  +   ++E +FE++W +L+P          AA   
Sbjct: 387 LQFCWLSPEKRPAAEDVHRLLTYLRLQSQRDSEVDFEQQWNALKPNTNSRDSSNNAA--- 443

Query: 435 LGGVVELAAASSFPLLEQFAGDGFHADGDDVLTVTETSRGLNFEYKWEAGRG-------- 486
                       FP+L+ FA D    + ++VLTVTETS+GL+FEY WEA +         
Sbjct: 444 ------------FPILDHFARDRLGREMEEVLTVTETSQGLSFEYVWEAAKHDHFDERSR 491

Query: 487 ---------------AEAFPATLSPGRTARLQELCAPDGAP---PGVVPVLSAHSPSLGS 528
                           E F ++LS     +  +  +    P   PGVVPV  AH+ S+GS
Sbjct: 492 GHLDEGLSYTSIFYPVEVFESSLSDPGPGKQDD--SGQDVPLRVPGVVPVFDAHNLSVGS 549

Query: 529 EYFIRLEEAAPAAGHDPDCAGCAPSPPATADQDDDSDGSTAASLA 573
           +Y+I+LEE    +G + +       PPA    D D+   T   L+
Sbjct: 550 DYYIQLEE---KSGSNLE----LDYPPALLTTDMDNPERTGPELS 587



 Score =  200 bits (508), Expect = 9e-51
 Identities = 184/599 (30%), Positives = 261/599 (43%), Gaps = 109/599 (18%)

Query: 835  VSAIKLASALNGSSSSPEVEAPSSEDEDTAEATSGIFTDTSSDGLQARRPDVVPAFRSLQ 894
            + A++  + LN   ++ E    S+   D+    S +      D L A  P   P+     
Sbjct: 944  LEAVETLNQLNSKDAAKEAGLVSALSSDSTSQDSLL-----EDSLSAPFPASEPSLE--- 995

Query: 895  KQVGTPDSLDSLDIPSSASDGGYEVFSPSATGPSGGQPRALDSGYDTENYESPEFVLKEA 954
                TPDSL+S+D+  +  D      +P    P     +  DSGY+TEN ESPE+ L  A
Sbjct: 996  ----TPDSLESVDVHEALLDS-LGSHTPQKLVPPD---KPADSGYETENLESPEWTLHPA 1047

Query: 955  QEGC---EPQAFAELASEGEGPGPETRLSTSLSG------------LNEKNPYRDSAYFS 999
             EG    EP    +    G  P P   +S +  G               +  YRDSAYFS
Sbjct: 1048 PEGTADSEPATTGDGGHSGLPPNPVIVISDAGDGHRGTEVTPETFTAGSQGSYRDSAYFS 1107

Query: 1000 DLEAEAEATS------GPEKKCGGDRAPGPELGLPSTGQPSEQVCLRPGVSGEAQGSGPG 1053
            D ++E E  S       P         P PE  LP     ++  CL      EA+ S P 
Sbjct: 1108 DNDSEPEKRSEEVPGTSPSALVLVQEQPLPEPVLPEQSPAAQDSCL------EARKSQPD 1161

Query: 1054 EVLPPLLQLEGSSPEPSTCPSGLVPEPPEPQGPAKVRPGPSPSCSQFFLLT--------- 1104
            E     L         +T      PEP +   P +V P    + S + +L          
Sbjct: 1162 ESCLSALHNSSDLELRAT------PEPAQTGVPQQVHPTEDEASSPWSVLNAELSSGDDF 1215

Query: 1105 ------PVPLRSEG-NSSEFQGPPGLLSGPAPQKRMGGPGTPRAPL------RLALPGLP 1151
                  P  L S G N++E           +      GP      +      +L + G+ 
Sbjct: 1216 ETQDDRPCTLASTGTNTNELLAYTNSALDKSLSSHSEGPKLKEPDIEGKYLGKLGVSGML 1275

Query: 1152 AALEGRPEEEEEDSEDSDESDEELRCYSVQEPSEDSEEEAPAVPVVVAESQSARNLRSLL 1211
               E   + +EED E+SD+SDE+LR +++   S +SE+E      ++  ++  R+LRSLL
Sbjct: 1276 DLSEDGMDADEED-ENSDDSDEDLRAFNLHSLSSESEDETEHPVPIILSNEDGRHLRSLL 1334

Query: 1212 KMPSLLS-ETFCEDLERKKKAVSFFDDVTVYLFDQESPTRELGEPFPGAKESPPTFLRGS 1270
            K  +  + +   ED +++KKAV+FFDDVTVYLFDQE+PT+ELG   P   E+    L G 
Sbjct: 1335 KPTAANAPDPLPEDWKKEKKAVTFFDDVTVYLFDQETPTKELG---PCGGEACGPDLSG- 1390

Query: 1271 PGSPSAPNRPQQADGSP--------NGSTAEEGGGFAWDDDF---PLMTAKAAFAMALDP 1319
                     P  A GSP          ST EEGGGF WDDDF   P M+   +  ++  P
Sbjct: 1391 ---------PAPASGSPYLSRCINSESSTDEEGGGFEWDDDFSPDPFMSKTTSNLLSSKP 1441

Query: 1320 --------AAPAPAAPT----PTPAPFSRFTVSPAPTSRFSITHVSDSDAESKRGPEAG 1366
                    + P PA  T    P  AP+SRF++SPA  + FS+TH++DSD E     E G
Sbjct: 1442 SLQTSKYFSPPPPARSTEQSWPHSAPYSRFSISPANIASFSLTHLTDSDIEQGGSSEDG 1500



 Score = 36.2 bits (82), Expect = 0.22
 Identities = 87/404 (21%), Positives = 138/404 (34%), Gaps = 64/404 (15%)

Query: 698  PVSAGGHAEGCPSPKQTPRASPEPGYPGEPLLGLQAASAQEPGCCPGLPHLCSAQGLAPA 757
            P  +G   E   SP+ T   +PE     EP            G  P    + S  G    
Sbjct: 1027 PADSGYETENLESPEWTLHPAPEGTADSEP---ATTGDGGHSGLPPNPVIVISDAGDGHR 1083

Query: 758  PCLVTPSWTETASSGG---------DHPQAEPKLATEAEGTTGPRL------PLPSVPSP 802
               VTP  T TA S G         D+     K + E  GT+   L      PLP    P
Sbjct: 1084 GTEVTPE-TFTAGSQGSYRDSAYFSDNDSEPEKRSEEVPGTSPSALVLVQEQPLPEPVLP 1142

Query: 803  SQEGAPLPSEEASAPDAPDALPDSPTPATGGEVSAIKLASALNGSSSSPEVEAPSSEDED 862
             Q     P+ + S  +A  + PD    +     S ++L +    + +    +   +EDE 
Sbjct: 1143 EQS----PAAQDSCLEARKSQPDESCLSALHNSSDLELRATPEPAQTGVPQQVHPTEDEA 1198

Query: 863  T-------AEATSGIFTDTSSDGLQARRPDVVPAFRSLQKQVGTPDSLDSLDIPSSASDG 915
            +       AE +SG   +T  D     RP  + +  +   ++    +  +LD   S+   
Sbjct: 1199 SSPWSVLNAELSSGDDFETQDD-----RPCTLASTGTNTNEL-LAYTNSALDKSLSSHSE 1252

Query: 916  GYEVFSPSATGPSGGQ---PRALDSGYDTENYESPEFVLKEAQEGCEPQAFAELASEGEG 972
            G ++  P   G   G+      LD   D  + +  +    ++ E         L+SE E 
Sbjct: 1253 GPKLKEPDIEGKYLGKLGVSGMLDLSEDGMDADEEDENSDDSDEDLRAFNLHSLSSESED 1312

Query: 973  -------------PGPETRLSTSLSGLNEKNPYRDS--------AYFSDLEAEAEATSGP 1011
                          G   R     +  N  +P  +          +F D+         P
Sbjct: 1313 ETEHPVPIILSNEDGRHLRSLLKPTAANAPDPLPEDWKKEKKAVTFFDDVTVYLFDQETP 1372

Query: 1012 EKKCG--GDRAPGPELG--LPSTGQPSEQVCLRPGVSGEAQGSG 1051
             K+ G  G  A GP+L    P++G P    C+    S + +G G
Sbjct: 1373 TKELGPCGGEACGPDLSGPAPASGSPYLSRCINSESSTDEEGGG 1416


>gi|239756966 PREDICTED: similar to arg tyrosine kinase [Homo
           sapiens]
          Length = 243

 Score =  212 bits (540), Expect = 2e-54
 Identities = 102/102 (100%), Positives = 102/102 (100%)

Query: 168 MQFLEEVQPYRALKHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRSCRVAESMAPDP 227
           MQFLEEVQPYRALKHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRSCRVAESMAPDP
Sbjct: 1   MQFLEEVQPYRALKHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRSCRVAESMAPDP 60

Query: 228 RTLQRMACEVACGVLHLHRNNFVHSDLALRNCLLTADLTVKI 269
           RTLQRMACEVACGVLHLHRNNFVHSDLALRNCLLTADLTVKI
Sbjct: 61  RTLQRMACEVACGVLHLHRNNFVHSDLALRNCLLTADLTVKI 102



 Score = 94.4 bits (233), Expect = 7e-19
 Identities = 45/51 (88%), Positives = 47/51 (92%)

Query: 1311 AAFAMALDPAAPAPAAPTPTPAPFSRFTVSPAPTSRFSITHVSDSDAESKR 1361
            A   + +DPAAPAPAAPTPTPAPFSRFTVSPAPTSRFSITHVSDSDAESKR
Sbjct: 96   ADLTVKIDPAAPAPAAPTPTPAPFSRFTVSPAPTSRFSITHVSDSDAESKR 146


>gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [Homo
            sapiens]
          Length = 1070

 Score =  172 bits (435), Expect = 3e-42
 Identities = 119/373 (31%), Positives = 190/373 (50%), Gaps = 30/373 (8%)

Query: 32   LAVVAVSFSGLFAVIVLMLACLC-CKKGGIGFKEFENAEGDEYAADLAQGSPATAAQNGP 90
            +  + +S     A I+ +L  +  CKK     +  +  EG+E   +   G P    Q   
Sbjct: 702  IQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSA 761

Query: 91   DVYVLPLTEVSLPMAKQPGRSVQLLKSTDVGRH----SLLYLKEIGRGWFGKVFLGE--- 143
            ++      EV+L        +     ST    H    SL  +  +G+  FG+VFL +   
Sbjct: 762  EIQ----EEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQG 817

Query: 144  VNSGISSAQVVVKELQASASVQEQMQFLEEVQPYRALKHSNLLQCLAQCAEVTPYLLVME 203
            +  G++   V+VK LQ S   Q+Q+ F  E++ +  L H+N+++ L  C E  P+ +V+E
Sbjct: 818  LEEGVAETLVLVKSLQ-SKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLE 876

Query: 204  FCPLGDLKGYLRSCRVA-ESMAPDP-RTLQRMAC--EVACGVLHLHRNNFVHSDLALRNC 259
            +  LGDLK +LR  +   E +   P  T Q++A   +VA G+ HL  N FVH DLA RNC
Sbjct: 877  YVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNC 936

Query: 260  LLTADLTVKIGDYGLAHCKYREDYFVTADQLWVPLRWIAPELVDEVHSNLLVVDQTKSGN 319
            L++A   VK+   GL+   Y  +Y+    Q WVPLRW++PE +       L  D +   +
Sbjct: 937  LVSAQRQVKVSALGLSKDVYNSEYY-HFRQAWVPLRWMSPEAI-------LEGDFSTKSD 988

Query: 320  VWSLGVTIWELFELGTQPYPQHSDQQVLAYTVREQQLKLPKPQLQLTLSDRWYEVMQFCW 379
            VW+ GV +WE+F  G  P+   +D +VLA  ++  + +LP+P+       + Y +MQ CW
Sbjct: 989  VWAFGVLMWEVFTHGEMPHGGQADDEVLA-DLQAGKARLPQPE---GCPSKLYRLMQRCW 1044

Query: 380  -LQPEQRPTAEEV 391
             L P+ RP+  E+
Sbjct: 1045 ALSPKDRPSFSEI 1057


>gi|22902130 PTK7 protein tyrosine kinase 7 isoform d precursor [Homo
            sapiens]
          Length = 1014

 Score =  172 bits (435), Expect = 3e-42
 Identities = 119/373 (31%), Positives = 190/373 (50%), Gaps = 30/373 (8%)

Query: 32   LAVVAVSFSGLFAVIVLMLACLC-CKKGGIGFKEFENAEGDEYAADLAQGSPATAAQNGP 90
            +  + +S     A I+ +L  +  CKK     +  +  EG+E   +   G P    Q   
Sbjct: 646  IQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSA 705

Query: 91   DVYVLPLTEVSLPMAKQPGRSVQLLKSTDVGRH----SLLYLKEIGRGWFGKVFLGE--- 143
            ++      EV+L        +     ST    H    SL  +  +G+  FG+VFL +   
Sbjct: 706  EIQ----EEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQG 761

Query: 144  VNSGISSAQVVVKELQASASVQEQMQFLEEVQPYRALKHSNLLQCLAQCAEVTPYLLVME 203
            +  G++   V+VK LQ S   Q+Q+ F  E++ +  L H+N+++ L  C E  P+ +V+E
Sbjct: 762  LEEGVAETLVLVKSLQ-SKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLE 820

Query: 204  FCPLGDLKGYLRSCRVA-ESMAPDP-RTLQRMAC--EVACGVLHLHRNNFVHSDLALRNC 259
            +  LGDLK +LR  +   E +   P  T Q++A   +VA G+ HL  N FVH DLA RNC
Sbjct: 821  YVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNC 880

Query: 260  LLTADLTVKIGDYGLAHCKYREDYFVTADQLWVPLRWIAPELVDEVHSNLLVVDQTKSGN 319
            L++A   VK+   GL+   Y  +Y+    Q WVPLRW++PE +       L  D +   +
Sbjct: 881  LVSAQRQVKVSALGLSKDVYNSEYY-HFRQAWVPLRWMSPEAI-------LEGDFSTKSD 932

Query: 320  VWSLGVTIWELFELGTQPYPQHSDQQVLAYTVREQQLKLPKPQLQLTLSDRWYEVMQFCW 379
            VW+ GV +WE+F  G  P+   +D +VLA  ++  + +LP+P+       + Y +MQ CW
Sbjct: 933  VWAFGVLMWEVFTHGEMPHGGQADDEVLA-DLQAGKARLPQPE---GCPSKLYRLMQRCW 988

Query: 380  -LQPEQRPTAEEV 391
             L P+ RP+  E+
Sbjct: 989  ALSPKDRPSFSEI 1001


>gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor
           [Homo sapiens]
          Length = 940

 Score =  172 bits (435), Expect = 3e-42
 Identities = 119/373 (31%), Positives = 190/373 (50%), Gaps = 30/373 (8%)

Query: 32  LAVVAVSFSGLFAVIVLMLACLC-CKKGGIGFKEFENAEGDEYAADLAQGSPATAAQNGP 90
           +  + +S     A I+ +L  +  CKK     +  +  EG+E   +   G P    Q   
Sbjct: 572 IQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSA 631

Query: 91  DVYVLPLTEVSLPMAKQPGRSVQLLKSTDVGRH----SLLYLKEIGRGWFGKVFLGE--- 143
           ++      EV+L        +     ST    H    SL  +  +G+  FG+VFL +   
Sbjct: 632 EIQ----EEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQG 687

Query: 144 VNSGISSAQVVVKELQASASVQEQMQFLEEVQPYRALKHSNLLQCLAQCAEVTPYLLVME 203
           +  G++   V+VK LQ S   Q+Q+ F  E++ +  L H+N+++ L  C E  P+ +V+E
Sbjct: 688 LEEGVAETLVLVKSLQ-SKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLE 746

Query: 204 FCPLGDLKGYLRSCRVA-ESMAPDP-RTLQRMAC--EVACGVLHLHRNNFVHSDLALRNC 259
           +  LGDLK +LR  +   E +   P  T Q++A   +VA G+ HL  N FVH DLA RNC
Sbjct: 747 YVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNC 806

Query: 260 LLTADLTVKIGDYGLAHCKYREDYFVTADQLWVPLRWIAPELVDEVHSNLLVVDQTKSGN 319
           L++A   VK+   GL+   Y  +Y+    Q WVPLRW++PE +       L  D +   +
Sbjct: 807 LVSAQRQVKVSALGLSKDVYNSEYY-HFRQAWVPLRWMSPEAI-------LEGDFSTKSD 858

Query: 320 VWSLGVTIWELFELGTQPYPQHSDQQVLAYTVREQQLKLPKPQLQLTLSDRWYEVMQFCW 379
           VW+ GV +WE+F  G  P+   +D +VLA  ++  + +LP+P+       + Y +MQ CW
Sbjct: 859 VWAFGVLMWEVFTHGEMPHGGQADDEVLA-DLQAGKARLPQPE---GCPSKLYRLMQRCW 914

Query: 380 -LQPEQRPTAEEV 391
            L P+ RP+  E+
Sbjct: 915 ALSPKDRPSFSEI 927


>gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor [Homo
            sapiens]
          Length = 1030

 Score =  172 bits (435), Expect = 3e-42
 Identities = 119/373 (31%), Positives = 190/373 (50%), Gaps = 30/373 (8%)

Query: 32   LAVVAVSFSGLFAVIVLMLACLC-CKKGGIGFKEFENAEGDEYAADLAQGSPATAAQNGP 90
            +  + +S     A I+ +L  +  CKK     +  +  EG+E   +   G P    Q   
Sbjct: 662  IQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSA 721

Query: 91   DVYVLPLTEVSLPMAKQPGRSVQLLKSTDVGRH----SLLYLKEIGRGWFGKVFLGE--- 143
            ++      EV+L        +     ST    H    SL  +  +G+  FG+VFL +   
Sbjct: 722  EIQ----EEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQG 777

Query: 144  VNSGISSAQVVVKELQASASVQEQMQFLEEVQPYRALKHSNLLQCLAQCAEVTPYLLVME 203
            +  G++   V+VK LQ S   Q+Q+ F  E++ +  L H+N+++ L  C E  P+ +V+E
Sbjct: 778  LEEGVAETLVLVKSLQ-SKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLE 836

Query: 204  FCPLGDLKGYLRSCRVA-ESMAPDP-RTLQRMAC--EVACGVLHLHRNNFVHSDLALRNC 259
            +  LGDLK +LR  +   E +   P  T Q++A   +VA G+ HL  N FVH DLA RNC
Sbjct: 837  YVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNC 896

Query: 260  LLTADLTVKIGDYGLAHCKYREDYFVTADQLWVPLRWIAPELVDEVHSNLLVVDQTKSGN 319
            L++A   VK+   GL+   Y  +Y+    Q WVPLRW++PE +       L  D +   +
Sbjct: 897  LVSAQRQVKVSALGLSKDVYNSEYY-HFRQAWVPLRWMSPEAI-------LEGDFSTKSD 948

Query: 320  VWSLGVTIWELFELGTQPYPQHSDQQVLAYTVREQQLKLPKPQLQLTLSDRWYEVMQFCW 379
            VW+ GV +WE+F  G  P+   +D +VLA  ++  + +LP+P+       + Y +MQ CW
Sbjct: 949  VWAFGVLMWEVFTHGEMPHGGQADDEVLA-DLQAGKARLPQPE---GCPSKLYRLMQRCW 1004

Query: 380  -LQPEQRPTAEEV 391
             L P+ RP+  E+
Sbjct: 1005 ALSPKDRPSFSEI 1017


>gi|119395738 insulin receptor isoform Short precursor [Homo sapiens]
          Length = 1370

 Score =  169 bits (428), Expect = 2e-41
 Identities = 107/295 (36%), Positives = 160/295 (54%), Gaps = 23/295 (7%)

Query: 111  SVQLLKSTDVGRHSLLYLKEIGRGWFGKVFLG---EVNSGISSAQVVVKELQASASVQEQ 167
            SV +    +V R  +  L+E+G+G FG V+ G   ++  G +  +V VK +  SAS++E+
Sbjct: 997  SVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRER 1056

Query: 168  MQFLEEVQPYRALKHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRSCRVAESMAPD- 226
            ++FL E    +     ++++ L   ++  P L+VME    GDLK YLRS R      P  
Sbjct: 1057 IEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGR 1116

Query: 227  -PRTLQ---RMACEVACGVLHLHRNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYRED 282
             P TLQ   +MA E+A G+ +L+   FVH DLA RNC++  D TVKIGD+G+    Y  D
Sbjct: 1117 PPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETD 1176

Query: 283  YFVTADQLWVPLRWIAPE-LVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQH 341
            Y+    +  +P+RW+APE L D V         T S ++WS GV +WE+  L  QPY   
Sbjct: 1177 YYRKGGKGLLPVRWMAPESLKDGVF--------TTSSDMWSFGVVLWEITSLAEQPYQGL 1228

Query: 342  SDQQVLAYTVREQQLKLPKPQLQLTLSDRWYEVMQFCW-LQPEQRPTAEEVHLLL 395
            S++QVL + +    L  P         +R  ++M+ CW   P+ RPT  E+  LL
Sbjct: 1229 SNEQVLKFVMDGGYLDQPD-----NCPERVTDLMRMCWQFNPKMRPTFLEIVNLL 1278


>gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]
          Length = 1382

 Score =  169 bits (428), Expect = 2e-41
 Identities = 107/295 (36%), Positives = 160/295 (54%), Gaps = 23/295 (7%)

Query: 111  SVQLLKSTDVGRHSLLYLKEIGRGWFGKVFLG---EVNSGISSAQVVVKELQASASVQEQ 167
            SV +    +V R  +  L+E+G+G FG V+ G   ++  G +  +V VK +  SAS++E+
Sbjct: 1009 SVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRER 1068

Query: 168  MQFLEEVQPYRALKHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRSCRVAESMAPD- 226
            ++FL E    +     ++++ L   ++  P L+VME    GDLK YLRS R      P  
Sbjct: 1069 IEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGR 1128

Query: 227  -PRTLQ---RMACEVACGVLHLHRNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYRED 282
             P TLQ   +MA E+A G+ +L+   FVH DLA RNC++  D TVKIGD+G+    Y  D
Sbjct: 1129 PPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETD 1188

Query: 283  YFVTADQLWVPLRWIAPE-LVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQH 341
            Y+    +  +P+RW+APE L D V         T S ++WS GV +WE+  L  QPY   
Sbjct: 1189 YYRKGGKGLLPVRWMAPESLKDGVF--------TTSSDMWSFGVVLWEITSLAEQPYQGL 1240

Query: 342  SDQQVLAYTVREQQLKLPKPQLQLTLSDRWYEVMQFCW-LQPEQRPTAEEVHLLL 395
            S++QVL + +    L  P         +R  ++M+ CW   P+ RPT  E+  LL
Sbjct: 1241 SNEQVLKFVMDGGYLDQPD-----NCPERVTDLMRMCWQFNPKMRPTFLEIVNLL 1290


>gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isoform
           c precursor [Homo sapiens]
          Length = 822

 Score =  161 bits (408), Expect = 4e-39
 Identities = 118/394 (29%), Positives = 197/394 (50%), Gaps = 40/394 (10%)

Query: 30  SSLAVVAVSFSGLFAVIVLMLACLCCKKGGIGFKEFEN--AEGDEYAADL---AQGSPA- 83
           S  AVV ++    F ++V++      +    G K   +  +  D+ A+ L   + GS   
Sbjct: 432 SVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTP 491

Query: 84  TAAQNGPDVYVLPLTEVSLPMAKQPG----RSVQLLKST---DVGRHSLLYLKEIGRGWF 136
           ++++ GPD  ++ +T++  P+ + P      + QL   T    + RH+++  +E+G G F
Sbjct: 492 SSSEGGPDAVIIGMTKI--PVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAF 549

Query: 137 GKVFLGEVNSGISSAQ---VVVKELQASASVQEQMQFLEEVQPYRALKHSNLLQCLAQCA 193
           GKVFL E  +         V VK L+  AS   +  F  E +    L+H ++++    C 
Sbjct: 550 GKVFLAECYNLCPEQDKILVAVKTLK-DASDNARKDFHREAELLTNLQHEHIVKFYGVCV 608

Query: 194 EVTPYLLVMEFCPLGDLKGYLRS-----CRVAESMAPDPRTLQRM---ACEVACGVLHLH 245
           E  P ++V E+   GDL  +LR+       +AE   P   T  +M   A ++A G+++L 
Sbjct: 609 EGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLA 668

Query: 246 RNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYREDYFVTADQLWVPLRWIAPELVDEV 305
             +FVH DLA RNCL+  +L VKIGD+G++   Y  DY+       +P+RW+ PE     
Sbjct: 669 SQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPE----- 723

Query: 306 HSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQVLAYTVREQQLKLPKPQLQL 365
             +++    T   +VWSLGV +WE+F  G QP+ Q S+ +V+    + + L+ P+     
Sbjct: 724 --SIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPR----- 776

Query: 366 TLSDRWYEVMQFCW-LQPEQRPTAEEVHLLLSYL 398
           T     YE+M  CW  +P  R   + +H LL  L
Sbjct: 777 TCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNL 810


>gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isoform
           a precursor [Homo sapiens]
          Length = 838

 Score =  160 bits (404), Expect = 1e-38
 Identities = 120/410 (29%), Positives = 201/410 (49%), Gaps = 56/410 (13%)

Query: 30  SSLAVVAVSFSGLFAVIVLMLACLCCKKGGIGFKEF--------ENAEG----------D 71
           S  AVV ++    F ++V++      +    G K+F        ++ +G          D
Sbjct: 432 SVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQGVGPASVISNDD 491

Query: 72  EYAADL---AQGSPA-TAAQNGPDVYVLPLTEVSLPMAKQPG----RSVQLLKST---DV 120
           + A+ L   + GS   ++++ GPD  ++ +T++  P+ + P      + QL   T    +
Sbjct: 492 DSASPLHHISNGSNTPSSSEGGPDAVIIGMTKI--PVIENPQYFGITNSQLKPDTFVQHI 549

Query: 121 GRHSLLYLKEIGRGWFGKVFLGEVNSGISSAQ---VVVKELQASASVQEQMQFLEEVQPY 177
            RH+++  +E+G G FGKVFL E  +         V VK L+  AS   +  F  E +  
Sbjct: 550 KRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLK-DASDNARKDFHREAELL 608

Query: 178 RALKHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRS-----CRVAESMAPDPRTLQR 232
             L+H ++++    C E  P ++V E+   GDL  +LR+       +AE   P   T  +
Sbjct: 609 TNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQ 668

Query: 233 M---ACEVACGVLHLHRNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYREDYFVTADQ 289
           M   A ++A G+++L   +FVH DLA RNCL+  +L VKIGD+G++   Y  DY+     
Sbjct: 669 MLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGH 728

Query: 290 LWVPLRWIAPELVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQVLAY 349
             +P+RW+ PE       +++    T   +VWSLGV +WE+F  G QP+ Q S+ +V+  
Sbjct: 729 TMLPIRWMPPE-------SIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIEC 781

Query: 350 TVREQQLKLPKPQLQLTLSDRWYEVMQFCW-LQPEQRPTAEEVHLLLSYL 398
             + + L+ P+     T     YE+M  CW  +P  R   + +H LL  L
Sbjct: 782 ITQGRVLQRPR-----TCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNL 826


>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
            sapiens]
          Length = 1367

 Score =  157 bits (397), Expect = 7e-38
 Identities = 96/283 (33%), Positives = 150/283 (53%), Gaps = 23/283 (8%)

Query: 119  DVGRHSLLYLKEIGRGWFGKVFLGEVNSGISS---AQVVVKELQASASVQEQMQFLEEVQ 175
            +V R  +   +E+G+G FG V+ G     +      +V +K +  +AS++E+++FL E  
Sbjct: 993  EVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEAS 1052

Query: 176  PYRALKHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRSCRVAESMAP--DPRTLQRM 233
              +     ++++ L   ++  P L++ME    GDLK YLRS R      P   P +L +M
Sbjct: 1053 VMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKM 1112

Query: 234  ---ACEVACGVLHLHRNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYREDYFVTADQL 290
               A E+A G+ +L+ N FVH DLA RNC++  D TVKIGD+G+    Y  DY+    + 
Sbjct: 1113 IQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKG 1172

Query: 291  WVPLRWIAPE-LVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQVLAY 349
             +P+RW++PE L D V         T   +VWS GV +WE+  L  QPY   S++QVL +
Sbjct: 1173 LLPVRWMSPESLKDGVF--------TTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRF 1224

Query: 350  TVREQQLKLPKPQLQLTLSDRWYEVMQFCW-LQPEQRPTAEEV 391
             +    L  P         D  +E+M+ CW   P+ RP+  E+
Sbjct: 1225 VMEGGLLDKPD-----NCPDMLFELMRMCWQYNPKMRPSFLEI 1262


>gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens]
          Length = 2347

 Score =  154 bits (390), Expect = 4e-37
 Identities = 96/274 (35%), Positives = 144/274 (52%), Gaps = 26/274 (9%)

Query: 131  IGRGWFGKVFLGE----VNSGISSAQVVVKELQASASVQEQMQFLEEVQPYRALKHSNLL 186
            +G G FG+V+ G     +  G    +V VK L+  ++ QE+++FL+E        H N+L
Sbjct: 1951 LGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNIL 2010

Query: 187  QCLAQCAEVTPYLLVMEFCPLGDLKGYLRSCRVAESMAP--DPRTLQRMACEVACGVLHL 244
            + L  C    P  +++E    GDL  YLR  R+A    P      L  +  +++ G ++L
Sbjct: 2011 KQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYL 2070

Query: 245  HRNNFVHSDLALRNCLL-----TADLTVKIGDYGLAHCKYREDYFVTADQLWVPLRWIAP 299
             R +F+H DLA RNCL+     T+   VKIGD+GLA   Y+ DY+    +  +P+RW+AP
Sbjct: 2071 ERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAP 2130

Query: 300  E-LVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQVLAYTVREQQLKL 358
            E L+D +         T   +VWS G+ IWE+  LG QPYP HS+  VL Y     +L+ 
Sbjct: 2131 ESLMDGIF--------TTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEP 2182

Query: 359  PKPQLQLTLSDRWYEVMQFCWLQ-PEQRPTAEEV 391
            P+        D  + +M  CW Q P+QRPT   +
Sbjct: 2183 PR-----NCPDDLWNLMTQCWAQEPDQRPTFHRI 2211


>gi|29029632 anaplastic lymphoma kinase [Homo sapiens]
          Length = 1620

 Score =  154 bits (389), Expect = 6e-37
 Identities = 93/287 (32%), Positives = 142/287 (49%), Gaps = 21/287 (7%)

Query: 109  GRSVQLLKSTDVGRHSLLYLKEIGRGWFGKVFLGEVN---SGISSAQVVVKELQASASVQ 165
            G++  +    +V R ++  ++ +G G FG+V+ G+V+   +  S  QV VK L    S Q
Sbjct: 1100 GKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQ 1159

Query: 166  EQMQFLEEVQPYRALKHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRSCRVAESMAP 225
            +++ FL E        H N+++C+    +  P  +++E    GDLK +LR  R   S   
Sbjct: 1160 DELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPS 1219

Query: 226  DPRTLQ--RMACEVACGVLHLHRNNFVHSDLALRNCLLTAD---LTVKIGDYGLAHCKYR 280
                L    +A ++ACG  +L  N+F+H D+A RNCLLT        KIGD+G+A   YR
Sbjct: 1220 SLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYR 1279

Query: 281  EDYFVTADQLWVPLRWIAPELVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQ 340
              Y+       +P++W+ PE   E          T   + WS GV +WE+F LG  PYP 
Sbjct: 1280 ASYYRKGGCAMLPVKWMPPEAFMEGIF-------TSKTDTWSFGVLLWEIFSLGYMPYPS 1332

Query: 341  HSDQQVLAYTVREQQLKLPKPQLQLTLSDRWYEVMQFCWL-QPEQRP 386
             S+Q+VL +     ++  PK           Y +M  CW  QPE RP
Sbjct: 1333 KSNQEVLEFVTSGGRMDPPK-----NCPGPVYRIMTQCWQHQPEDRP 1374


>gi|62420886 discoidin domain receptor family, member 2 precursor
           [Homo sapiens]
          Length = 855

 Score =  153 bits (387), Expect = 1e-36
 Identities = 108/319 (33%), Positives = 166/319 (52%), Gaps = 41/319 (12%)

Query: 108 PGRSVQLLKSTDVG-----RHSLLYLKEIGRGWFGKVFLGEVNS-----------GISSA 151
           P  ++ LL   DV      R  L + +++G G FG+V L EV              +S+ 
Sbjct: 541 PAVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSAN 600

Query: 152 Q---VVVKELQASASVQEQMQFLEEVQPYRALKHSNLLQCLAQCAEVTPYLLVMEFCPLG 208
           Q   V VK L+A A+   +  FL+E++    LK  N++  LA C    P  ++ E+   G
Sbjct: 601 QPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENG 660

Query: 209 DLKGYLRSCRVAESMAPDPRT-----LQRMACEVACGVLHLHRNNFVHSDLALRNCLLTA 263
           DL  +L       S + D RT     L+ MA ++A G+ +L   NFVH DLA RNCL+  
Sbjct: 661 DLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGK 720

Query: 264 DLTVKIGDYGLAHCKYREDYFVTADQLWVPLRWIAPELVDEVHSNLLVVDQTKSGNVWSL 323
           + T+KI D+G++   Y  DY+    +  +P+RW++ E       ++L+   T + +VW+ 
Sbjct: 721 NYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWE-------SILLGKFTTASDVWAF 773

Query: 324 GVTIWELFEL-GTQPYPQHSDQQVLAYT---VREQ--QLKLPKPQLQLTLSDRWYEVMQF 377
           GVT+WE F     QPY Q SD+QV+  T    R+Q  Q  LP+P +     D  Y++M  
Sbjct: 774 GVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAI---CPDSVYKLMLS 830

Query: 378 CWLQ-PEQRPTAEEVHLLL 395
           CW +  + RP+ +E+HLLL
Sbjct: 831 CWRRDTKNRPSFQEIHLLL 849


>gi|62420884 discoidin domain receptor family, member 2 precursor
           [Homo sapiens]
          Length = 855

 Score =  153 bits (387), Expect = 1e-36
 Identities = 108/319 (33%), Positives = 166/319 (52%), Gaps = 41/319 (12%)

Query: 108 PGRSVQLLKSTDVG-----RHSLLYLKEIGRGWFGKVFLGEVNS-----------GISSA 151
           P  ++ LL   DV      R  L + +++G G FG+V L EV              +S+ 
Sbjct: 541 PAVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSAN 600

Query: 152 Q---VVVKELQASASVQEQMQFLEEVQPYRALKHSNLLQCLAQCAEVTPYLLVMEFCPLG 208
           Q   V VK L+A A+   +  FL+E++    LK  N++  LA C    P  ++ E+   G
Sbjct: 601 QPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENG 660

Query: 209 DLKGYLRSCRVAESMAPDPRT-----LQRMACEVACGVLHLHRNNFVHSDLALRNCLLTA 263
           DL  +L       S + D RT     L+ MA ++A G+ +L   NFVH DLA RNCL+  
Sbjct: 661 DLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGK 720

Query: 264 DLTVKIGDYGLAHCKYREDYFVTADQLWVPLRWIAPELVDEVHSNLLVVDQTKSGNVWSL 323
           + T+KI D+G++   Y  DY+    +  +P+RW++ E       ++L+   T + +VW+ 
Sbjct: 721 NYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWE-------SILLGKFTTASDVWAF 773

Query: 324 GVTIWELFEL-GTQPYPQHSDQQVLAYT---VREQ--QLKLPKPQLQLTLSDRWYEVMQF 377
           GVT+WE F     QPY Q SD+QV+  T    R+Q  Q  LP+P +     D  Y++M  
Sbjct: 774 GVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAI---CPDSVYKLMLS 830

Query: 378 CWLQ-PEQRPTAEEVHLLL 395
           CW +  + RP+ +E+HLLL
Sbjct: 831 CWRRDTKNRPSFQEIHLLL 849


>gi|31657140 insulin receptor-related receptor precursor [Homo
            sapiens]
          Length = 1297

 Score =  153 bits (386), Expect = 1e-36
 Identities = 113/338 (33%), Positives = 172/338 (50%), Gaps = 45/338 (13%)

Query: 119  DVGRHSLLYLKEIGRGWFGKVFLG---EVNSGISSAQVVVKELQASASVQEQMQFLEEVQ 175
            +V R  +  ++E+G+G FG V+ G    + +G  S  V +K +   AS +E ++FL+E  
Sbjct: 973  EVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPRECIEFLKEAS 1032

Query: 176  PYRALKHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRSCRV-AESMAPDPRT----L 230
              +A K  ++++ L   ++  P L++ME    GDLK +LRS R  AE+    P+     +
Sbjct: 1033 VMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAENNPGLPQPALGEM 1092

Query: 231  QRMACEVACGVLHLHRNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYREDYFVTADQL 290
             +MA E+A G+ +L  N FVH DLA RNC+++ D TVKIGD+G+    Y  DY+    + 
Sbjct: 1093 IQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKGGKG 1152

Query: 291  WVPLRWIAPE-LVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQVLAY 349
             +P+RW+APE L D +         T   +VWS GV +WE+  L  QPY   S++QVL +
Sbjct: 1153 LLPVRWMAPESLKDGIF--------TTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKF 1204

Query: 350  TVREQQL-KLPKPQLQLTLSDRWYEVMQFCW----------------LQPEQRPTAEEVH 392
             +    L +L    LQL       E+M  CW                +Q E RP+   + 
Sbjct: 1205 VMDGGVLEELEGCPLQL------QELMSRCWQPNPRLRPSFTHILDSIQEELRPSFRLLS 1258

Query: 393  LLLSYLC--AKGA---TEAEEEFERRWRSLRPGGGGVG 425
               S  C  A+G+   T+AE +     R   P  GG G
Sbjct: 1259 FYYSPECRGARGSLPTTDAEPDSSPTPRDCSPQNGGPG 1296


>gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isoform
           1 [Homo sapiens]
          Length = 790

 Score =  151 bits (381), Expect = 5e-36
 Identities = 96/293 (32%), Positives = 152/293 (51%), Gaps = 27/293 (9%)

Query: 120 VGRHSLLYLKEIGRGWFGKVFLGEVNSGISSAQ---VVVKELQASASVQEQMQFLEEVQP 176
           + R  ++   E+G G FGKVFL E ++ +       V VK L+  AS   +  F  E + 
Sbjct: 499 IKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK-EASESARQDFQREAEL 557

Query: 177 YRALKHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRS-------CRVAESMAPDPRT 229
              L+H ++++    C E  P L+V E+   GDL  +LRS           E +AP P  
Sbjct: 558 LTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLG 617

Query: 230 LQRM---ACEVACGVLHLHRNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYREDYFVT 286
           L ++   A +VA G+++L   +FVH DLA RNCL+   L VKIGD+G++   Y  DY+  
Sbjct: 618 LGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRV 677

Query: 287 ADQLWVPLRWIAPELVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQV 346
             +  +P+RW+ PE       ++L    T   +VWS GV +WE+F  G QP+ Q S+ + 
Sbjct: 678 GGRTMLPIRWMPPE-------SILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEA 730

Query: 347 LAYTVREQQLKLPKPQLQLTLSDRWYEVMQFCW-LQPEQRPTAEEVHLLLSYL 398
           +    + ++L+ P+           Y +M+ CW  +P+QR + ++VH  L  L
Sbjct: 731 IDCITQGRELERPR-----ACPPEVYAIMRGCWQREPQQRHSIKDVHARLQAL 778


>gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isoform 2
           [Homo sapiens]
          Length = 796

 Score =  151 bits (381), Expect = 5e-36
 Identities = 96/293 (32%), Positives = 152/293 (51%), Gaps = 27/293 (9%)

Query: 120 VGRHSLLYLKEIGRGWFGKVFLGEVNSGISSAQ---VVVKELQASASVQEQMQFLEEVQP 176
           + R  ++   E+G G FGKVFL E ++ +       V VK L+  AS   +  F  E + 
Sbjct: 505 IKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK-EASESARQDFQREAEL 563

Query: 177 YRALKHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRS-------CRVAESMAPDPRT 229
              L+H ++++    C E  P L+V E+   GDL  +LRS           E +AP P  
Sbjct: 564 LTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLG 623

Query: 230 LQRM---ACEVACGVLHLHRNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYREDYFVT 286
           L ++   A +VA G+++L   +FVH DLA RNCL+   L VKIGD+G++   Y  DY+  
Sbjct: 624 LGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRV 683

Query: 287 ADQLWVPLRWIAPELVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQV 346
             +  +P+RW+ PE       ++L    T   +VWS GV +WE+F  G QP+ Q S+ + 
Sbjct: 684 GGRTMLPIRWMPPE-------SILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEA 736

Query: 347 LAYTVREQQLKLPKPQLQLTLSDRWYEVMQFCW-LQPEQRPTAEEVHLLLSYL 398
           +    + ++L+ P+           Y +M+ CW  +P+QR + ++VH  L  L
Sbjct: 737 IDCITQGRELERPR-----ACPPEVYAIMRGCWQREPQQRHSIKDVHARLQAL 784


>gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isoform
           3 [Homo sapiens]
          Length = 760

 Score =  151 bits (381), Expect = 5e-36
 Identities = 96/293 (32%), Positives = 152/293 (51%), Gaps = 27/293 (9%)

Query: 120 VGRHSLLYLKEIGRGWFGKVFLGEVNSGISSAQ---VVVKELQASASVQEQMQFLEEVQP 176
           + R  ++   E+G G FGKVFL E ++ +       V VK L+  AS   +  F  E + 
Sbjct: 469 IKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK-EASESARQDFQREAEL 527

Query: 177 YRALKHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRS-------CRVAESMAPDPRT 229
              L+H ++++    C E  P L+V E+   GDL  +LRS           E +AP P  
Sbjct: 528 LTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLG 587

Query: 230 LQRM---ACEVACGVLHLHRNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYREDYFVT 286
           L ++   A +VA G+++L   +FVH DLA RNCL+   L VKIGD+G++   Y  DY+  
Sbjct: 588 LGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRV 647

Query: 287 ADQLWVPLRWIAPELVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQV 346
             +  +P+RW+ PE       ++L    T   +VWS GV +WE+F  G QP+ Q S+ + 
Sbjct: 648 GGRTMLPIRWMPPE-------SILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEA 700

Query: 347 LAYTVREQQLKLPKPQLQLTLSDRWYEVMQFCW-LQPEQRPTAEEVHLLLSYL 398
           +    + ++L+ P+           Y +M+ CW  +P+QR + ++VH  L  L
Sbjct: 701 IDCITQGRELERPR-----ACPPEVYAIMRGCWQREPQQRHSIKDVHARLQAL 748


>gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precursor
           [Homo sapiens]
          Length = 864

 Score =  149 bits (376), Expect = 2e-35
 Identities = 95/290 (32%), Positives = 148/290 (51%), Gaps = 23/290 (7%)

Query: 118 TDVGRHSLLYLKEIGRGWFGKVFLGEV---NSGISSAQVVVKELQASASVQEQMQFLEEV 174
           T+V   ++  L+ +G G FG+V+ G V       S  QV +K L    S Q+++ FL E 
Sbjct: 503 TEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEA 562

Query: 175 QPYRALKHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRSCRVAESMAPDP---RTLQ 231
                 +H N+++C+      TP L+++E    GD+K +LR  R      P P   R L 
Sbjct: 563 LIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSR-PHLGQPSPLVMRDLL 621

Query: 232 RMACEVACGVLHLHRNNFVHSDLALRNCLLTA---DLTVKIGDYGLAHCKYREDYFVTAD 288
           ++A ++A G  +L  N+F+H D+A RNCLL+        KIGD+G+A   YR  Y+   D
Sbjct: 622 QLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGD 681

Query: 289 QLWVPLRWIAPELVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQVLA 348
           +  +P++W+ PE   E     +   +T S   WS GV +WE+F LG  PYP  ++Q+VL 
Sbjct: 682 RALLPVKWMPPEAFLEG----IFTSKTDS---WSFGVLLWEIFSLGYMPYPGRTNQEVLD 734

Query: 349 YTVREQQLKLPKPQLQLTLSDRWYEVMQFCWL-QPEQRPTAEEVHLLLSY 397
           + V   ++  P+           Y +M  CW  +PE RP+   +   L Y
Sbjct: 735 FVVGGGRMDPPR-----GCPGPVYRIMTQCWQHEPELRPSFASILERLQY 779


>gi|46249416 leukocyte receptor tyrosine kinase isoform 2 precursor
           [Homo sapiens]
          Length = 803

 Score =  149 bits (376), Expect = 2e-35
 Identities = 95/290 (32%), Positives = 148/290 (51%), Gaps = 23/290 (7%)

Query: 118 TDVGRHSLLYLKEIGRGWFGKVFLGEV---NSGISSAQVVVKELQASASVQEQMQFLEEV 174
           T+V   ++  L+ +G G FG+V+ G V       S  QV +K L    S Q+++ FL E 
Sbjct: 442 TEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEA 501

Query: 175 QPYRALKHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRSCRVAESMAPDP---RTLQ 231
                 +H N+++C+      TP L+++E    GD+K +LR  R      P P   R L 
Sbjct: 502 LIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSR-PHLGQPSPLVMRDLL 560

Query: 232 RMACEVACGVLHLHRNNFVHSDLALRNCLLTA---DLTVKIGDYGLAHCKYREDYFVTAD 288
           ++A ++A G  +L  N+F+H D+A RNCLL+        KIGD+G+A   YR  Y+   D
Sbjct: 561 QLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGD 620

Query: 289 QLWVPLRWIAPELVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQVLA 348
           +  +P++W+ PE   E     +   +T S   WS GV +WE+F LG  PYP  ++Q+VL 
Sbjct: 621 RALLPVKWMPPEAFLEG----IFTSKTDS---WSFGVLLWEIFSLGYMPYPGRTNQEVLD 673

Query: 349 YTVREQQLKLPKPQLQLTLSDRWYEVMQFCWL-QPEQRPTAEEVHLLLSY 397
           + V   ++  P+           Y +M  CW  +PE RP+   +   L Y
Sbjct: 674 FVVGGGRMDPPR-----GCPGPVYRIMTQCWQHEPELRPSFASILERLQY 718


>gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens]
          Length = 869

 Score =  148 bits (373), Expect = 4e-35
 Identities = 108/398 (27%), Positives = 174/398 (43%), Gaps = 50/398 (12%)

Query: 29  PSSLAVVAVSFSGLFAVIVLML--ACLCCKKGGIGFKEFENAEGDEYAADLAQGSPATAA 86
           P+    V +S    FA+ VL+      CC++     K+++N + +  A  L         
Sbjct: 490 PTYSMTVIISIMSSFAIFVLLTITTLYCCRRR----KQWKNKKRESAAVTLT-------- 537

Query: 87  QNGPDVYVLPLTEVSLPMAKQPGRSVQLLKSTDVGRHSLLYLKEIGRGWFGKVFLGEVNS 146
              P   +L     +    + P      L S +  R+++ Y+++IG G FG+VF      
Sbjct: 538 -TLPSELLLDRLHPNPMYQRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPG 596

Query: 147 GISS---AQVVVKELQASASVQEQMQFLEEVQPYRALKHSNLLQCLAQCAEVTPYLLVME 203
            +       V VK L+  AS   Q  F  E        + N+++ L  CA   P  L+ E
Sbjct: 597 LLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFE 656

Query: 204 FCPLGDLKGYLRS------CRVAES----------MAPDPRTLQRMAC---EVACGVLHL 244
           +   GDL  +LRS      C ++ S            P P +     C   +VA G+ +L
Sbjct: 657 YMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYL 716

Query: 245 HRNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYREDYFVTADQLWVPLRWIAPELVDE 304
               FVH DLA RNCL+  ++ VKI D+GL+   Y  DY+   +   +P+RW+ PE    
Sbjct: 717 SERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPE---- 772

Query: 305 VHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQVLAYTVREQQLKLPKPQLQ 364
              ++     T   +VW+ GV +WE+F  G QPY   + ++V+ Y      L  P+    
Sbjct: 773 ---SIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPE---- 825

Query: 365 LTLSDRWYEVMQFCWLQ-PEQRPTAEEVHLLLSYLCAK 401
                  Y +M+ CW + P  RP+   +H +L  +C +
Sbjct: 826 -NCPVELYNLMRLCWSKLPADRPSFTSIHRILERMCER 862


>gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isoform
           b precursor [Homo sapiens]
          Length = 825

 Score =  144 bits (364), Expect = 4e-34
 Identities = 105/393 (26%), Positives = 186/393 (47%), Gaps = 37/393 (9%)

Query: 31  SLAVVAVSFSGLFAVIVLMLACLCCKKGGIGFK-EFENAEGDEYAAD----LAQG-SPAT 84
           S+AV   +F+ +  V++ ++     ++   G K       G+E +A     +  G +  +
Sbjct: 433 SIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPS 492

Query: 85  AAQNGPDVYVLPLTEVSLPMAKQPGRSVQLLKSTD-----VGRHSLLYLKEIGRGWFGKV 139
           +   GPD  V+ +T + +    Q  R        D     + R  ++  +E+G G FGKV
Sbjct: 493 SLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKV 552

Query: 140 FLGEVN--SGISSAQVVVKELQASASVQEQMQFLEEVQPYRALKHSNLLQCLAQCAEVTP 197
           FL E    S      +V  +     ++  +  F  E +    L+H ++++    C +  P
Sbjct: 553 FLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDP 612

Query: 198 YLLVMEFCPLGDLKGYLRSCRVAESMAPDPRTLQ-----------RMACEVACGVLHLHR 246
            ++V E+   GDL  +LR+      +  D +  Q            +A ++A G+++L  
Sbjct: 613 LIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLAS 672

Query: 247 NNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYREDYFVTADQLWVPLRWIAPELVDEVH 306
            +FVH DLA RNCL+ A+L VKIGD+G++   Y  DY+       +P+RW+ PE      
Sbjct: 673 QHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPE------ 726

Query: 307 SNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQVLAYTVREQQLKLPKPQLQLT 366
            +++    T   +VWS GV +WE+F  G QP+ Q S+ +V+    + + L+ P+      
Sbjct: 727 -SIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPR-----V 780

Query: 367 LSDRWYEVMQFCW-LQPEQRPTAEEVHLLLSYL 398
                Y+VM  CW  +P+QR   +E++ +L  L
Sbjct: 781 CPKEVYDVMLGCWQREPQQRLNIKEIYKILHAL 813


>gi|21536468 AXL receptor tyrosine kinase isoform 2 [Homo sapiens]
          Length = 885

 Score =  142 bits (358), Expect = 2e-33
 Identities = 99/328 (30%), Positives = 161/328 (49%), Gaps = 25/328 (7%)

Query: 115 LKSTDVGRHSLLYLKEIGRGWFGKVFLGEVNSGISSAQVVVKELQASASVQEQMQ-FLEE 173
           L+   V RH +   K +G G FG V  G++N   S  +V VK ++ +   + +++ FL E
Sbjct: 517 LRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSE 576

Query: 174 VQPYRALKHSNLLQCLAQCAEVTPY------LLVMEFCPLGDLKGYLRSCRVAESMAPDP 227
               +   H N+++ +  C + +        ++++ F   GDL  +L   R+ +     P
Sbjct: 577 AVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLP 636

Query: 228 -RTLQRMACEVACGVLHLHRNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYREDYFVT 286
            + L +   ++A G+ +L    F+H DLA RNC+L  +++V + D+GL+   Y  DY+  
Sbjct: 637 TQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQ 696

Query: 287 ADQLWVPLRWIAPE-LVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQ 345
                +P++WIA E L D V+        T   +VWS GVT+WE+   G  PYP   + +
Sbjct: 697 GRIAKMPVKWIAIESLADRVY--------TSKSDVWSFGVTMWEIATRGQTPYPGVENSE 748

Query: 346 VLAYTVREQQLKLPKPQLQLTLSDRWYEVMQFCW-LQPEQRPTAEEVHLLLSYLCAKGAT 404
           +  Y  +  +LK P   L     D  Y +M  CW L P+ RP+  E+   L     K   
Sbjct: 749 IYDYLRQGNRLKQPADCL-----DGLYALMSRCWELNPQDRPSFTELREDLEN-TLKALP 802

Query: 405 EAEEEFERRWRSLRPGGGGVGPGPGAAG 432
            A+E  E  + ++  GGG   P PGAAG
Sbjct: 803 PAQEPDEILYVNMDEGGGYPEP-PGAAG 829


>gi|21536466 AXL receptor tyrosine kinase isoform 1 [Homo sapiens]
          Length = 894

 Score =  142 bits (358), Expect = 2e-33
 Identities = 99/328 (30%), Positives = 161/328 (49%), Gaps = 25/328 (7%)

Query: 115 LKSTDVGRHSLLYLKEIGRGWFGKVFLGEVNSGISSAQVVVKELQASASVQEQMQ-FLEE 173
           L+   V RH +   K +G G FG V  G++N   S  +V VK ++ +   + +++ FL E
Sbjct: 526 LRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSE 585

Query: 174 VQPYRALKHSNLLQCLAQCAEVTPY------LLVMEFCPLGDLKGYLRSCRVAESMAPDP 227
               +   H N+++ +  C + +        ++++ F   GDL  +L   R+ +     P
Sbjct: 586 AVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLP 645

Query: 228 -RTLQRMACEVACGVLHLHRNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYREDYFVT 286
            + L +   ++A G+ +L    F+H DLA RNC+L  +++V + D+GL+   Y  DY+  
Sbjct: 646 TQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQ 705

Query: 287 ADQLWVPLRWIAPE-LVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQ 345
                +P++WIA E L D V+        T   +VWS GVT+WE+   G  PYP   + +
Sbjct: 706 GRIAKMPVKWIAIESLADRVY--------TSKSDVWSFGVTMWEIATRGQTPYPGVENSE 757

Query: 346 VLAYTVREQQLKLPKPQLQLTLSDRWYEVMQFCW-LQPEQRPTAEEVHLLLSYLCAKGAT 404
           +  Y  +  +LK P   L     D  Y +M  CW L P+ RP+  E+   L     K   
Sbjct: 758 IYDYLRQGNRLKQPADCL-----DGLYALMSRCWELNPQDRPSFTELREDLEN-TLKALP 811

Query: 405 EAEEEFERRWRSLRPGGGGVGPGPGAAG 432
            A+E  E  + ++  GGG   P PGAAG
Sbjct: 812 PAQEPDEILYVNMDEGGGYPEP-PGAAG 838


>gi|66932918 MER receptor tyrosine kinase precursor [Homo sapiens]
          Length = 999

 Score =  140 bits (353), Expect = 8e-33
 Identities = 94/294 (31%), Positives = 147/294 (50%), Gaps = 23/294 (7%)

Query: 115 LKSTDVGRHSLLYLKEIGRGWFGKVFLGEVNSGI-SSAQVVVKELQASASVQEQMQ-FLE 172
           L+   + R+ L+  K +G G FG V  G +     +S +V VK ++   S Q +++ FL 
Sbjct: 577 LEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLS 636

Query: 173 EVQPYRALKHSNLLQCLAQCAEVTPY-----LLVMEFCPLGDLKGYLRSCRVAESMAPDP 227
           E    +   H N+++ L  C E++       ++++ F   GDL  YL   R+       P
Sbjct: 637 EAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIP 696

Query: 228 -RTLQRMACEVACGVLHLHRNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYREDYFVT 286
            +TL +   ++A G+ +L   NF+H DLA RNC+L  D+TV + D+GL+   Y  DY+  
Sbjct: 697 LQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQ 756

Query: 287 ADQLWVPLRWIAPE-LVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQ 345
                +P++WIA E L D V+        T   +VW+ GVT+WE+   G  PYP   + +
Sbjct: 757 GRIAKMPVKWIAIESLADRVY--------TSKSDVWAFGVTMWEIATRGMTPYPGVQNHE 808

Query: 346 VLAYTVREQQLKLPKPQLQLTLSDRWYEVMQFCW-LQPEQRPTAEEVHLLLSYL 398
           +  Y +   +LK P+  L     D  YE+M  CW   P  RPT   + L L  L
Sbjct: 809 MYDYLLHGHRLKQPEDCL-----DELYEIMYSCWRTDPLDRPTFSVLRLQLEKL 857


>gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens]
          Length = 675

 Score =  136 bits (343), Expect = 1e-31
 Identities = 88/274 (32%), Positives = 138/274 (50%), Gaps = 23/274 (8%)

Query: 119 DVGRHSLLYLKEIGRGWFGKVFLGEVNSGISSAQVVVKELQASASVQEQMQFLEEVQPYR 178
           ++ R  +  LKE+G G FG V LG+       A  ++KE     S+ E  +F +E Q   
Sbjct: 411 ELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKE----GSMSED-EFFQEAQTMM 465

Query: 179 ALKHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRSCRVAESMAPDPRTLQRMACEVA 238
            L H  L++    C++  P  +V E+   G L  YLRS         +P  L  M  +V 
Sbjct: 466 KLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRS----HGKGLEPSQLLEMCYDVC 521

Query: 239 CGVLHLHRNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYREDYFVTADQLWVPLRWIA 298
            G+  L  + F+H DLA RNCL+  DL VK+ D+G+      +D +V++     P++W A
Sbjct: 522 EGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTR-YVLDDQYVSSVGTKFPVKWSA 580

Query: 299 PELVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQVLAYTVREQQLKL 358
           PE+             +   +VW+ G+ +WE+F LG QPY  + + QV+      Q  +L
Sbjct: 581 PEVFH-------YFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKV--SQGHRL 631

Query: 359 PKPQLQLTLSDRWYEVMQFCWLQ-PEQRPTAEEV 391
            +P L    SD  Y++M  CW + PE+RPT +++
Sbjct: 632 YRPHL---ASDTIYQIMYSCWHELPEKRPTFQQL 662


>gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens]
          Length = 675

 Score =  136 bits (343), Expect = 1e-31
 Identities = 88/274 (32%), Positives = 138/274 (50%), Gaps = 23/274 (8%)

Query: 119 DVGRHSLLYLKEIGRGWFGKVFLGEVNSGISSAQVVVKELQASASVQEQMQFLEEVQPYR 178
           ++ R  +  LKE+G G FG V LG+       A  ++KE     S+ E  +F +E Q   
Sbjct: 411 ELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKE----GSMSED-EFFQEAQTMM 465

Query: 179 ALKHSNLLQCLAQCAEVTPYLLVMEFCPLGDLKGYLRSCRVAESMAPDPRTLQRMACEVA 238
            L H  L++    C++  P  +V E+   G L  YLRS         +P  L  M  +V 
Sbjct: 466 KLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRS----HGKGLEPSQLLEMCYDVC 521

Query: 239 CGVLHLHRNNFVHSDLALRNCLLTADLTVKIGDYGLAHCKYREDYFVTADQLWVPLRWIA 298
            G+  L  + F+H DLA RNCL+  DL VK+ D+G+      +D +V++     P++W A
Sbjct: 522 EGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTR-YVLDDQYVSSVGTKFPVKWSA 580

Query: 299 PELVDEVHSNLLVVDQTKSGNVWSLGVTIWELFELGTQPYPQHSDQQVLAYTVREQQLKL 358
           PE+             +   +VW+ G+ +WE+F LG QPY  + + QV+      Q  +L
Sbjct: 581 PEVFH-------YFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKV--SQGHRL 631

Query: 359 PKPQLQLTLSDRWYEVMQFCWLQ-PEQRPTAEEV 391
            +P L    SD  Y++M  CW + PE+RPT +++
Sbjct: 632 YRPHL---ASDTIYQIMYSCWHELPEKRPTFQQL 662


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.131    0.399 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 70,503,318
Number of Sequences: 37866
Number of extensions: 4607023
Number of successful extensions: 39721
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 611
Number of HSP's successfully gapped in prelim test: 1721
Number of HSP's that attempted gapping in prelim test: 23730
Number of HSP's gapped (non-prelim): 13397
length of query: 1374
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1259
effective length of database: 13,892,928
effective search space: 17491196352
effective search space used: 17491196352
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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