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Search of human proteins with 106879210
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|106879210 Src homology 2 domain containing adaptor protein B
[Homo sapiens]
(509 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|106879210 Src homology 2 domain containing adaptor protein B ... 1041 0.0
gi|111074524 Src homology 2 domain containing F [Homo sapiens] 289 5e-78
gi|222537752 Src homology 2 domain containing transforming prote... 249 3e-66
gi|58219064 Src homology 2 domain containing E [Homo sapiens] 229 4e-60
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 58 2e-08
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 58 2e-08
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 58 2e-08
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 58 2e-08
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 58 2e-08
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 56 7e-08
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 56 7e-08
gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens] 56 7e-08
gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens] 56 7e-08
gi|117320537 phospholipase C, gamma 2 [Homo sapiens] 53 7e-07
gi|222446609 rai-like protein [Homo sapiens] 52 1e-06
gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens] 52 2e-06
gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens] 52 2e-06
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens] 52 2e-06
gi|5453754 NCK adaptor protein 1 [Homo sapiens] 51 3e-06
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 49 1e-05
gi|32455252 phosphoinositide-3-kinase, regulatory subunit 1 (alp... 49 1e-05
gi|32455250 phosphoinositide-3-kinase, regulatory subunit 1 (alp... 49 1e-05
gi|32455248 phosphoinositide-3-kinase, regulatory subunit 1 (alp... 49 1e-05
gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens] 49 1e-05
gi|166795247 phosphoinositide-3-kinase, regulatory subunit 3 (p5... 49 1e-05
gi|166795245 phosphoinositide-3-kinase, regulatory subunit 3 (p5... 49 1e-05
gi|33356177 protein tyrosine phosphatase, non-receptor type 11 [... 48 2e-05
gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens] 48 2e-05
gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens] 48 2e-05
gi|216547801 SH2 domain containing 3C isoform e [Homo sapiens] 47 4e-05
>gi|106879210 Src homology 2 domain containing adaptor protein B
[Homo sapiens]
Length = 509
Score = 1041 bits (2692), Expect = 0.0
Identities = 509/509 (100%), Positives = 509/509 (100%)
Query: 1 MAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATA 60
MAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATA
Sbjct: 1 MAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATA 60
Query: 61 SCFSASSGSLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGE 120
SCFSASSGSLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGE
Sbjct: 61 SCFSASSGSLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGE 120
Query: 121 PGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGSPHLYRSSSERRPATPAEVRYIS 180
PGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGSPHLYRSSSERRPATPAEVRYIS
Sbjct: 121 PGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGSPHLYRSSSERRPATPAEVRYIS 180
Query: 181 PKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKV 240
PKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKV
Sbjct: 181 PKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKV 240
Query: 241 TIADDYSDPFDAKNDLKSKAGKGESAGYMEPYEAQRIMTEFQRQESVRSQHKGIQLYDTP 300
TIADDYSDPFDAKNDLKSKAGKGESAGYMEPYEAQRIMTEFQRQESVRSQHKGIQLYDTP
Sbjct: 241 TIADDYSDPFDAKNDLKSKAGKGESAGYMEPYEAQRIMTEFQRQESVRSQHKGIQLYDTP 300
Query: 301 YEPEGQSVDSDSESTVSPRLRESKLPQDDDRPADEYDQPWEWNRVTIPALAAQFNGNEKR 360
YEPEGQSVDSDSESTVSPRLRESKLPQDDDRPADEYDQPWEWNRVTIPALAAQFNGNEKR
Sbjct: 301 YEPEGQSVDSDSESTVSPRLRESKLPQDDDRPADEYDQPWEWNRVTIPALAAQFNGNEKR 360
Query: 361 QSSPSPSRDRRRQLRAPGGGFKPIKHGSPEFCGILGERVDPAVPLEKQIWYHGAISRGDA 420
QSSPSPSRDRRRQLRAPGGGFKPIKHGSPEFCGILGERVDPAVPLEKQIWYHGAISRGDA
Sbjct: 361 QSSPSPSRDRRRQLRAPGGGFKPIKHGSPEFCGILGERVDPAVPLEKQIWYHGAISRGDA 420
Query: 421 ENLLRLCKECSYLVRNSQTSKHDYSLSLRSNQGFMHMKLAKTKEKYVLGQNSPPFDSVPE 480
ENLLRLCKECSYLVRNSQTSKHDYSLSLRSNQGFMHMKLAKTKEKYVLGQNSPPFDSVPE
Sbjct: 421 ENLLRLCKECSYLVRNSQTSKHDYSLSLRSNQGFMHMKLAKTKEKYVLGQNSPPFDSVPE 480
Query: 481 VIHYYTTRKLPIKGAEHLSLLYPVAVRTL 509
VIHYYTTRKLPIKGAEHLSLLYPVAVRTL
Sbjct: 481 VIHYYTTRKLPIKGAEHLSLLYPVAVRTL 509
>gi|111074524 Src homology 2 domain containing F [Homo sapiens]
Length = 423
Score = 289 bits (739), Expect = 5e-78
Identities = 178/406 (43%), Positives = 220/406 (54%), Gaps = 69/406 (16%)
Query: 169 RPATPAEVRYISPKHRLIKVESAAGGGAGDPLGGACAGGRTWS----PTACGGKKLLNKC 224
R +P + SPK L + + PL CA S P A G K+
Sbjct: 22 RQGSPGHRKRASPKGSLSSAQPHSWMLTPSPLNSHCAHREPISSSPQPVANGPKQKKKSN 81
Query: 225 AASAAEESGAGKKDKV-----TIADDYSDPFDAKNDLKSKAGKG-------ESAGYMEPY 272
S +D++ I +DY+DPFD + + AG E+ GYMEPY
Sbjct: 82 WRSTTRLRIIRLRDRLEPRPLAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYMEPY 141
Query: 273 EAQRIMTEFQRQESVRSQHKGIQLYDTPYEPEGQSVDSDSESTVSPRLRESKLPQDDDRP 332
EAQ++M E + + +Q + LYDTPYEPE + E PR ES+LP+DD+RP
Sbjct: 142 EAQKMMAEIRGSKETATQP--LPLYDTPYEPEEDGATPEGEGAPWPR--ESRLPEDDERP 197
Query: 333 ADEYDQPWEWNRVTI--------------------------------------------- 347
+EYDQPWEW + I
Sbjct: 198 PEEYDQPWEWKKERISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPE 257
Query: 348 PAL---AAQFNGNEKRQSSPSPSRDRRRQLRAPGGGFKPIKHGSPEFCGILGERVDPAVP 404
P+L +AQF G EK SP R R G K K S E LGE DPA+P
Sbjct: 258 PSLEDSSAQFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALP 317
Query: 405 LEKQIWYHGAISRGDAENLLRLCKECSYLVRNSQTSKHDYSLSLRSNQGFMHMKLAKTKE 464
LE Q+WYHGAISR DAENLLRLCKE SYLVRNS+TSK+D+SLSL+S+QGFMHMKL++TKE
Sbjct: 318 LENQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKE 377
Query: 465 -KYVLGQNSPPFDSVPEVIHYYTTRKLPIKGAEHLSLLYPVAVRTL 509
KYVLGQNSPPF SVPE++H+Y +RKLPIKGAEH+SLLYPVA+RTL
Sbjct: 378 HKYVLGQNSPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL 423
>gi|222537752 Src homology 2 domain containing transforming protein
D [Homo sapiens]
Length = 340
Score = 249 bits (637), Expect = 3e-66
Identities = 183/510 (35%), Positives = 233/510 (45%), Gaps = 173/510 (33%)
Query: 1 MAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATA 60
MAKWL Y S G + PPQPP PDY E
Sbjct: 1 MAKWLRDYLSFGGRRP--PPQPPTPDYTE------------------------------- 27
Query: 61 SCFSASSGSLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGE 120
SD++RAYRAQK DFEDPY S L A G S
Sbjct: 28 -----------------SDILRAYRAQKNLDFEDPYEDAESRLEPDPA-----GPGDSKN 65
Query: 121 PGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGSPHLYRSSSERRPATPAEVRYIS 180
PG + GSP
Sbjct: 66 PG------------------------------DAKYGSP--------------------- 74
Query: 181 PKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKV 240
KHRLIKVE+A A LG G +++
Sbjct: 75 -KHRLIKVEAADMARAKALLG---------------------------------GPGEEL 100
Query: 241 TIADDYSDPFDAKNDLKSKAGKGESAGYMEPYEAQRIMTEFQRQESVRSQHKGIQLYDTP 300
+Y DPFDA+ GYMEPY+AQ +M+E +G+QLYDTP
Sbjct: 101 EADTEYLDPFDAQ-----PHPAPPDDGYMEPYDAQWVMSEL--------PGRGVQLYDTP 147
Query: 301 YEPEGQSVDSDSESTVSPRLRESKLPQDDDRPADEYDQPWEWNRVTIP-ALAAQFNGNEK 359
YE + S P R+S++PQ+D+RPADEYDQPWEW + I A A QF+ E
Sbjct: 148 YEEQDPETADGPPSGQKP--RQSRMPQEDERPADEYDQPWEWKKDHISRAFAVQFDSPEW 205
Query: 360 RQSSPSPSRDRRRQLRAPGGGFKPIKHGSPEFCGILGERVDPAVPLEKQIWYHGAISRGD 419
++ S RR R+P +P ERVDPA+PLEKQ W+HG ++R D
Sbjct: 206 ERTPGSAKELRRPPPRSP----QP------------AERVDPALPLEKQPWFHGPLNRAD 249
Query: 420 AENLLRLCKECSYLVRNSQTSKHDYSLSLRSNQGFMHMKLAKTKE-KYVLGQNSPPFDSV 478
AE+LL LCKE SYLVR S+T+ D SLSLRS+QGF+H+K A+T+E + VLGQ+S PF SV
Sbjct: 250 AESLLSLCKEGSYLVRLSETNPQDCSLSLRSSQGFLHLKFARTRENQVVLGQHSGPFPSV 309
Query: 479 PEVIHYYTTRKLPIKGAEHLSLLYPVAVRT 508
PE++ +Y++R LP++GAEHL+LLYPV +T
Sbjct: 310 PELVLHYSSRPLPVQGAEHLALLYPVVTQT 339
>gi|58219064 Src homology 2 domain containing E [Homo sapiens]
Length = 495
Score = 229 bits (584), Expect = 4e-60
Identities = 160/446 (35%), Positives = 229/446 (51%), Gaps = 69/446 (15%)
Query: 98 GPGSSLRKLRAMCRLDYCGGSGEPGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSG 157
GPG + + L GSG GV S S G A++G G +S ++
Sbjct: 75 GPGPGKGRKNSAAEL----GSGR-AGVGPKDSRLSRDSLQGLIQAAAGKGRK-NSRATEE 128
Query: 158 SPHLYRSSSERRPATPAE--VRYISPKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTAC 215
PH R AT + YI+ RLIKV++ G + + + + S +
Sbjct: 129 EPH--------RGATKSSGCSTYIN---RLIKVDTQEKNGKSNYPSSSSSSSSSSSSASS 177
Query: 216 GGKKLLNKCAASAAEESGAGK----KDKVTIADDYSDPFDAKNDLKSKAGK--GESAGYM 269
+S E GK ++ V I +DY+DP+DAK + + GE+ GYM
Sbjct: 178 S--------PSSLGPELDKGKIIKQQETVIILEDYADPYDAKRTKGQRDAERVGENDGYM 229
Query: 270 EPYEAQRIMTEFQRQESVRSQHKGIQLYDTPYEPEGQSVDSDS----------------- 312
EPY+AQ+++TE +R+ S K +QL D+P EP + S++
Sbjct: 230 EPYDAQQMITEIRRRGSKDPLVKALQLLDSPCEPADGGLKSETLAKRRSSKDLLGKPPQL 289
Query: 313 -ESTVSP-----------RLRESKLPQDDDRPADEYDQPWEWNRVTIP-ALAAQFNGNEK 359
++ P R +S+LP++D+RPA EY+QPWEW + I AL+ QF G E+
Sbjct: 290 YDTPYEPAEGGPRAEGKARPPDSRLPENDERPAAEYEQPWEWKKEQIVRALSVQFEGAER 349
Query: 360 RQSSPSPSRDRRRQLRAPGGGFKPIKHGSPEFCGILGERVDPAVPLEKQIWYHGAISRGD 419
R RQ KP E GE+VDP +PLEKQ WYHGAISR +
Sbjct: 350 PSFREETVRQHHRQKSWTQKILKPALSDHSE-----GEKVDPGLPLEKQPWYHGAISRAE 404
Query: 420 AENLLRLCKECSYLVRNSQTSKHDYSLSLRSNQGFMHMKLAKTKE-KYVLGQNSPPFDSV 478
AE+ L+ CKE YLVRNS++ YS++L+++QG +H+ +A+TK+ KY L Q S FDS+
Sbjct: 405 AESRLQPCKEAGYLVRNSESGNSRYSIALKTSQGCVHIIVAQTKDNKYTLNQTSAVFDSI 464
Query: 479 PEVIHYYTTRKLPIKGAEHLSLLYPV 504
PEV+HYY+ KLP KGAEH++LLYPV
Sbjct: 465 PEVVHYYSNEKLPFKGAEHMTLLYPV 490
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 58.2 bits (139), Expect = 2e-08
Identities = 31/89 (34%), Positives = 47/89 (52%)
Query: 399 VDPAVPLEKQIWYHGAISRGDAENLLRLCKECSYLVRNSQTSKHDYSLSLRSNQGFMHMK 458
+ P LEK WYHG +SR AE LL S+LVR S++S S+SLR H +
Sbjct: 147 ITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYR 206
Query: 459 LAKTKEKYVLGQNSPPFDSVPEVIHYYTT 487
+ T + V F ++ E++H+++T
Sbjct: 207 INTTADGKVYVTAESRFSTLAELVHHHST 235
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 58.2 bits (139), Expect = 2e-08
Identities = 31/89 (34%), Positives = 47/89 (52%)
Query: 399 VDPAVPLEKQIWYHGAISRGDAENLLRLCKECSYLVRNSQTSKHDYSLSLRSNQGFMHMK 458
+ P LEK WYHG +SR AE LL S+LVR S++S S+SLR H +
Sbjct: 162 ITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYR 221
Query: 459 LAKTKEKYVLGQNSPPFDSVPEVIHYYTT 487
+ T + V F ++ E++H+++T
Sbjct: 222 INTTADGKVYVTAESRFSTLAELVHHHST 250
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 58.2 bits (139), Expect = 2e-08
Identities = 31/89 (34%), Positives = 47/89 (52%)
Query: 399 VDPAVPLEKQIWYHGAISRGDAENLLRLCKECSYLVRNSQTSKHDYSLSLRSNQGFMHMK 458
+ P LEK WYHG +SR AE LL S+LVR S++S S+SLR H +
Sbjct: 141 ITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYR 200
Query: 459 LAKTKEKYVLGQNSPPFDSVPEVIHYYTT 487
+ T + V F ++ E++H+++T
Sbjct: 201 INTTADGKVYVTAESRFSTLAELVHHHST 229
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 58.2 bits (139), Expect = 2e-08
Identities = 31/89 (34%), Positives = 47/89 (52%)
Query: 399 VDPAVPLEKQIWYHGAISRGDAENLLRLCKECSYLVRNSQTSKHDYSLSLRSNQGFMHMK 458
+ P LEK WYHG +SR AE LL S+LVR S++S S+SLR H +
Sbjct: 147 ITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYR 206
Query: 459 LAKTKEKYVLGQNSPPFDSVPEVIHYYTT 487
+ T + V F ++ E++H+++T
Sbjct: 207 INTTADGKVYVTAESRFSTLAELVHHHST 235
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 58.2 bits (139), Expect = 2e-08
Identities = 31/89 (34%), Positives = 47/89 (52%)
Query: 399 VDPAVPLEKQIWYHGAISRGDAENLLRLCKECSYLVRNSQTSKHDYSLSLRSNQGFMHMK 458
+ P LEK WYHG +SR AE LL S+LVR S++S S+SLR H +
Sbjct: 126 ITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYR 185
Query: 459 LAKTKEKYVLGQNSPPFDSVPEVIHYYTT 487
+ T + V F ++ E++H+++T
Sbjct: 186 INTTADGKVYVTAESRFSTLAELVHHHST 214
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 56.2 bits (134), Expect = 7e-08
Identities = 29/89 (32%), Positives = 48/89 (53%)
Query: 399 VDPAVPLEKQIWYHGAISRGDAENLLRLCKECSYLVRNSQTSKHDYSLSLRSNQGFMHMK 458
+ P LEK WYHG +SR AE LL S+LVR S++S S+SLR H +
Sbjct: 116 ITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYR 175
Query: 459 LAKTKEKYVLGQNSPPFDSVPEVIHYYTT 487
+ + + + F+++ E++H+++T
Sbjct: 176 INTASDGKLYVSSESRFNTLAELVHHHST 204
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 56.2 bits (134), Expect = 7e-08
Identities = 29/89 (32%), Positives = 48/89 (53%)
Query: 399 VDPAVPLEKQIWYHGAISRGDAENLLRLCKECSYLVRNSQTSKHDYSLSLRSNQGFMHMK 458
+ P LEK WYHG +SR AE LL S+LVR S++S S+SLR H +
Sbjct: 135 ITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYR 194
Query: 459 LAKTKEKYVLGQNSPPFDSVPEVIHYYTT 487
+ + + + F+++ E++H+++T
Sbjct: 195 INTASDGKLYVSSESRFNTLAELVHHHST 223
>gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]
Length = 1047
Score = 56.2 bits (134), Expect = 7e-08
Identities = 30/89 (33%), Positives = 52/89 (58%), Gaps = 4/89 (4%)
Query: 404 PLEKQIWYHGAISRGDAENLLRLCKE-CSYLVRNSQTSKHDYSLSLRSNQGFMHMKLAKT 462
P E +IW+HG IS+ +A NLL + CS+LVR S + DYSL R+N+ K+ T
Sbjct: 345 PHEGKIWFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPT 404
Query: 463 -KEKYVLGQNSPPFDSVPEVIHYYTTRKL 490
++++G ++S+ ++I +Y ++
Sbjct: 405 PNNQFMMGGRY--YNSIGDIIDHYRKEQI 431
Score = 50.8 bits (120), Expect = 3e-06
Identities = 47/151 (31%), Positives = 64/151 (42%), Gaps = 29/151 (19%)
Query: 377 PGGGFKPIKHGSPEFCGILG-----------------ERVDPAVPLEK---QIWYHGAIS 416
PGGGF P+ P + LG E + A+PL WYHG +
Sbjct: 130 PGGGFPPLP--PPPYLPPLGAGLGTVDEGDSLDGPEYEEEEVAIPLTAPPTNQWYHGKLD 187
Query: 417 RGDAENLLRLC-KECSYLVRNSQTSKHDYSLSLRSNQGFM-HMKLAKTKEKYVLGQNSPP 474
R AE LR K SYL+R S + LS S + H ++ Y +G
Sbjct: 188 RTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYYIGGRR-- 245
Query: 475 FDSVPEVIHYYTTRKLPIKGAEHLSLLYPVA 505
F S+ ++I YY+ +KG + LLYPVA
Sbjct: 246 FSSLSDLIGYYSHVSCLLKGEK---LLYPVA 273
>gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens]
Length = 870
Score = 56.2 bits (134), Expect = 7e-08
Identities = 30/89 (33%), Positives = 52/89 (58%), Gaps = 4/89 (4%)
Query: 404 PLEKQIWYHGAISRGDAENLLRLCKE-CSYLVRNSQTSKHDYSLSLRSNQGFMHMKLAKT 462
P E +IW+HG IS+ +A NLL + CS+LVR S + DYSL R+N+ K+ T
Sbjct: 168 PHEGKIWFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPT 227
Query: 463 -KEKYVLGQNSPPFDSVPEVIHYYTTRKL 490
++++G ++S+ ++I +Y ++
Sbjct: 228 PNNQFMMGGRY--YNSIGDIIDHYRKEQI 254
Score = 46.6 bits (109), Expect = 5e-05
Identities = 34/98 (34%), Positives = 47/98 (47%), Gaps = 7/98 (7%)
Query: 410 WYHGAISRGDAENLLRLC-KECSYLVRNSQTSKHDYSLSLRSNQGFM-HMKLAKTKEKYV 467
WYHG + R AE LR K SYL+R S + LS S + H ++ Y
Sbjct: 4 WYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYY 63
Query: 468 LGQNSPPFDSVPEVIHYYTTRKLPIKGAEHLSLLYPVA 505
+G F S+ ++I YY+ +KG + LLYPVA
Sbjct: 64 IGGRR--FSSLSDLIGYYSHVSCLLKGEK---LLYPVA 96
>gi|117320537 phospholipase C, gamma 2 [Homo sapiens]
Length = 1265
Score = 52.8 bits (125), Expect = 7e-07
Identities = 33/107 (30%), Positives = 60/107 (56%), Gaps = 7/107 (6%)
Query: 404 PLEKQIWYHGAISRGDAEN-LLRLCKECSYLVRNSQTSKHDYSLSLRSNQGFMHMKLAKT 462
P E + WY+ ++SRG+AE+ L+R+ ++ ++L+R + S Y+++ R+ H ++ +
Sbjct: 640 PHESKPWYYDSLSRGEAEDMLMRIPRDGAFLIRKREGS-DSYAITFRARGKVKHCRINRD 698
Query: 463 KEKYVLGQNSPPFDSVPEVIHYYTTRKLPIKGAEHLSLLYPVAVRTL 509
+VLG S F+S+ E++ YY L K + L YPV L
Sbjct: 699 GRHFVLG-TSAYFESLVELVSYYEKHSLYRK----MRLRYPVTPELL 740
Score = 38.5 bits (88), Expect = 0.015
Identities = 36/107 (33%), Positives = 54/107 (50%), Gaps = 15/107 (14%)
Query: 410 WYHGAIS-RGDAENLLR-LC-----KECSYLVRNSQTSKHDYSLSLRSNQGFMHMKLAKT 462
W+H + R AE LL+ C K+ ++LVR S+T +DY+LS + H ++ T
Sbjct: 532 WFHKKVEKRTSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRST 591
Query: 463 KE----KYVLGQNSPPFDSVPEVIHYYTTRKLPIKGAE-HLSLLYPV 504
E KY L N F S+ +I +Y R+ ++ AE L L PV
Sbjct: 592 MEGGTLKYYLTDNL-TFSSIYALIQHY--RETHLRCAEFELRLTDPV 635
>gi|222446609 rai-like protein [Homo sapiens]
Length = 630
Score = 52.0 bits (123), Expect = 1e-06
Identities = 44/134 (32%), Positives = 59/134 (44%), Gaps = 20/134 (14%)
Query: 387 GSPEFCGILGERVDPAVP-----------LEKQIW----YHGAISRGDAENLLRLCKECS 431
GSP CG E V P +++Q+W YHG +SR AE+L L K+
Sbjct: 488 GSPWHCGKAPETVQPGATAQPASSHSLPHIKQQLWSEECYHGKLSRKAAESL--LVKDGD 545
Query: 432 YLVRNSQTSKHDYSLSLRSNQGFMHMKLAKTKEKYVLGQNSPPFDSVPEVIHYYTTRKLP 491
+LVR S TS Y LS H+ L + K + FD+V +I Y+ LP
Sbjct: 546 FLVRESATSPGQYVLSGLQGGQAKHLLLVDPEGK--VRTKDHVFDNVGHLIRYHMDNSLP 603
Query: 492 -IKGAEHLSLLYPV 504
I +SL PV
Sbjct: 604 IISSGSEVSLKQPV 617
>gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 51.6 bits (122), Expect = 2e-06
Identities = 32/96 (33%), Positives = 54/96 (56%), Gaps = 5/96 (5%)
Query: 410 WYHGAISRGDAENLLR-LCKECSYLVRNSQTSKHDYSLSLRSNQGFMHMKLAKTKEKYVL 468
WY+G ++R AE L E +L+R+S++S D+S+SL+++ H K+ Y +
Sbjct: 285 WYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSVSLKASGKNKHFKVQLVDNVYCI 344
Query: 469 GQNSPPFDSVPEVIHYYTTRKLPIKGAEHLSLLYPV 504
GQ F ++ E++ +Y +K PI +EH LY V
Sbjct: 345 GQRR--FHTMDELVEHY--KKAPIFTSEHGEKLYLV 376
>gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 51.6 bits (122), Expect = 2e-06
Identities = 32/96 (33%), Positives = 54/96 (56%), Gaps = 5/96 (5%)
Query: 410 WYHGAISRGDAENLLR-LCKECSYLVRNSQTSKHDYSLSLRSNQGFMHMKLAKTKEKYVL 468
WY+G ++R AE L E +L+R+S++S D+S+SL+++ H K+ Y +
Sbjct: 285 WYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSVSLKASGKNKHFKVQLVDNVYCI 344
Query: 469 GQNSPPFDSVPEVIHYYTTRKLPIKGAEHLSLLYPV 504
GQ F ++ E++ +Y +K PI +EH LY V
Sbjct: 345 GQRR--FHTMDELVEHY--KKAPIFTSEHGEKLYLV 376
>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
Length = 822
Score = 51.6 bits (122), Expect = 2e-06
Identities = 32/91 (35%), Positives = 50/91 (54%), Gaps = 5/91 (5%)
Query: 404 PLEKQIWYHGAISRGDAENLLRLCKECSYLVRNSQTSKHDYSLSLRSNQGFMHMKLAKTK 463
PL +Q WYHGAI R +A+ LL+ K+ +LVR S +Y LS+ S+ H +
Sbjct: 454 PLAEQDWYHGAIPRIEAQELLK--KQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVD 511
Query: 464 EKYVLGQNSPPFDSVPEVI-HYYTTRKLPIK 493
Y F ++P++I H+YTT+++ K
Sbjct: 512 NMYRF--EGTGFSNIPQLIDHHYTTKQVITK 540
>gi|5453754 NCK adaptor protein 1 [Homo sapiens]
Length = 377
Score = 50.8 bits (120), Expect = 3e-06
Identities = 31/96 (32%), Positives = 54/96 (56%), Gaps = 5/96 (5%)
Query: 410 WYHGAISRGDAENLLR-LCKECSYLVRNSQTSKHDYSLSLRSNQGFMHMKLAKTKEKYVL 468
WY+G ++R AE L E +L+R+S++S +D+S+SL++ H K+ + Y +
Sbjct: 282 WYYGKVTRHQAEMALNERGHEGDFLIRDSESSPNDFSVSLKAQGKNKHFKVQLKETVYCI 341
Query: 469 GQNSPPFDSVPEVIHYYTTRKLPIKGAEHLSLLYPV 504
GQ F ++ E++ +Y +K PI +E LY V
Sbjct: 342 GQRK--FSTMEELVEHY--KKAPIFTSEQGEKLYLV 373
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 48.9 bits (115), Expect = 1e-05
Identities = 42/142 (29%), Positives = 72/142 (50%), Gaps = 16/142 (11%)
Query: 36 RPSQPPQAVPQASSAASASCGPATASCFSASSGSLPDDSGSTSDLIRAYRAQKERDFEDP 95
+P++ ++ +SS++S+S +++S S+SSGS DS +S ++ A K P
Sbjct: 2525 QPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKR--VPSP 2582
Query: 96 YNGPGSSLRKLRAMCRLDYCGGSGEPGGVQR----AFSASSASGAAGCCCASSGAGAAAS 151
P ++R+ G EP +R + S+SS+S ++ +SS + +++S
Sbjct: 2583 TPAPKEAVRE----------GRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSS 2632
Query: 152 SSSSSGSPHLYRSSSERRPATP 173
SSSSS S SSS PA P
Sbjct: 2633 SSSSSSSSSSSSSSSSPSPAKP 2654
Score = 43.1 bits (100), Expect = 6e-04
Identities = 89/390 (22%), Positives = 144/390 (36%), Gaps = 62/390 (15%)
Query: 11 LGNSKTKSPPQPPRPDYREQRRR-------GERPSQ---------PPQAVPQASSAASAS 54
L +++++PP P R G+ PSQ P VP A S S
Sbjct: 2402 LDRARSRTPPSAPSQSRMTSERAPSPSSRMGQAPSQSLLPPAQDQPRSPVPSAFSDQSRC 2461
Query: 55 CGPAT---ASCFSASSGSLPDDSGSTSD----LIRAYRAQKERDFEDPYNGPGSSLRKLR 107
T A S SSG++ + S D L D +P G+ ++
Sbjct: 2462 LIAQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSDVGEPPASTGA--QQPS 2519
Query: 108 AMCRLDYCGGSGEPGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGSPHLYRSSSE 167
A+ L +P +R+ S+SS+S ++ SS + +++SSSSSSGS SS
Sbjct: 2520 ALAAL-------QPAKERRSSSSSSSSSSS-----SSSSSSSSSSSSSSGS----SSSDS 2563
Query: 168 RRPATPAEVRYISPKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAAS 227
+ P + P+ L +V S A GR PT K+ + ++S
Sbjct: 2564 EGSSLP-----VQPEVALKRVPSPTPAPK-----EAVREGRPPEPTPAKRKRRSSSSSSS 2613
Query: 228 AAEESGAGKKDKVTIADDYSDPFDAKNDLKSKAGKGESAGYMEPYEAQRIMTEFQRQESV 287
++ S + S + + S + S+ P A+ + S
Sbjct: 2614 SSSSSSSSSSS--------SSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASP 2665
Query: 288 RSQHKGIQLYDTPYEPEGQSVDSDSESTVSPRLRESKLPQDDDRPADEYDQPWEWNRVTI 347
+ G + +P +P DS S S SP R PQ P D+ E
Sbjct: 2666 KKPPPGERRSRSPRKPIDSLRDSRSLS-YSPVERRRPSPQPS--PRDQQSSSSERGSRRG 2722
Query: 348 PALAAQFNGNEKRQSSPSPSRDRRRQLRAP 377
++ +++R+ +PSP R R R+P
Sbjct: 2723 QRGDSRSPSHKRRRETPSPRPMRHRSSRSP 2752
>gi|32455252 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
isoform 2 [Homo sapiens]
Length = 454
Score = 48.5 bits (114), Expect = 1e-05
Identities = 36/104 (34%), Positives = 54/104 (51%), Gaps = 5/104 (4%)
Query: 405 LEKQIWYHGAISRGDAENLLRLCKECSYLVRNSQTSKH-DYSLSLRSNQGFMHMKLAKTK 463
L+ WY G ISR + LR + ++LVR++ T H DY+L+LR +K+
Sbjct: 58 LQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRD 117
Query: 464 EKYVLGQNSP-PFDSVPEVIHYYTTRKLPIKGAE-HLSLLYPVA 505
KY G + P F SV E+I++Y L + + LLYPV+
Sbjct: 118 GKY--GFSDPLTFSSVVELINHYRNESLAQYNPKLDVKLLYPVS 159
Score = 41.2 bits (95), Expect = 0.002
Identities = 29/100 (29%), Positives = 53/100 (53%), Gaps = 2/100 (2%)
Query: 406 EKQIWYHGAISRGDAENLLRLCKECSYLVRNSQTSKHDYSLSLRSNQGFMHMKLAKTKEK 465
+++ W G+ +R AENLLR ++ ++LVR S + + Y+ S+ + H + KT
Sbjct: 350 DEKTWNVGSSNRNKAENLLRGKRDGTFLVRES-SKQGCYACSVVVDGEVKHCVINKTATG 408
Query: 466 YVLGQNSPPFDSVPE-VIHYYTTRKLPIKGAEHLSLLYPV 504
Y + + S+ E V+HY T + + +++L YPV
Sbjct: 409 YGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPV 448
>gi|32455250 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
isoform 3 [Homo sapiens]
Length = 424
Score = 48.5 bits (114), Expect = 1e-05
Identities = 36/104 (34%), Positives = 54/104 (51%), Gaps = 5/104 (4%)
Query: 405 LEKQIWYHGAISRGDAENLLRLCKECSYLVRNSQTSKH-DYSLSLRSNQGFMHMKLAKTK 463
L+ WY G ISR + LR + ++LVR++ T H DY+L+LR +K+
Sbjct: 28 LQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRD 87
Query: 464 EKYVLGQNSP-PFDSVPEVIHYYTTRKLPIKGAE-HLSLLYPVA 505
KY G + P F SV E+I++Y L + + LLYPV+
Sbjct: 88 GKY--GFSDPLTFSSVVELINHYRNESLAQYNPKLDVKLLYPVS 129
Score = 41.2 bits (95), Expect = 0.002
Identities = 29/100 (29%), Positives = 53/100 (53%), Gaps = 2/100 (2%)
Query: 406 EKQIWYHGAISRGDAENLLRLCKECSYLVRNSQTSKHDYSLSLRSNQGFMHMKLAKTKEK 465
+++ W G+ +R AENLLR ++ ++LVR S + + Y+ S+ + H + KT
Sbjct: 320 DEKTWNVGSSNRNKAENLLRGKRDGTFLVRES-SKQGCYACSVVVDGEVKHCVINKTATG 378
Query: 466 YVLGQNSPPFDSVPE-VIHYYTTRKLPIKGAEHLSLLYPV 504
Y + + S+ E V+HY T + + +++L YPV
Sbjct: 379 YGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPV 418
>gi|32455248 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
isoform 1 [Homo sapiens]
Length = 724
Score = 48.5 bits (114), Expect = 1e-05
Identities = 36/104 (34%), Positives = 54/104 (51%), Gaps = 5/104 (4%)
Query: 405 LEKQIWYHGAISRGDAENLLRLCKECSYLVRNSQTSKH-DYSLSLRSNQGFMHMKLAKTK 463
L+ WY G ISR + LR + ++LVR++ T H DY+L+LR +K+
Sbjct: 328 LQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRD 387
Query: 464 EKYVLGQNSP-PFDSVPEVIHYYTTRKLPIKGAE-HLSLLYPVA 505
KY G + P F SV E+I++Y L + + LLYPV+
Sbjct: 388 GKY--GFSDPLTFSSVVELINHYRNESLAQYNPKLDVKLLYPVS 429
Score = 41.2 bits (95), Expect = 0.002
Identities = 29/100 (29%), Positives = 53/100 (53%), Gaps = 2/100 (2%)
Query: 406 EKQIWYHGAISRGDAENLLRLCKECSYLVRNSQTSKHDYSLSLRSNQGFMHMKLAKTKEK 465
+++ W G+ +R AENLLR ++ ++LVR S + + Y+ S+ + H + KT
Sbjct: 620 DEKTWNVGSSNRNKAENLLRGKRDGTFLVRES-SKQGCYACSVVVDGEVKHCVINKTATG 678
Query: 466 YVLGQNSPPFDSVPE-VIHYYTTRKLPIKGAEHLSLLYPV 504
Y + + S+ E V+HY T + + +++L YPV
Sbjct: 679 YGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPV 718
>gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens]
Length = 330
Score = 48.5 bits (114), Expect = 1e-05
Identities = 27/82 (32%), Positives = 45/82 (54%), Gaps = 3/82 (3%)
Query: 410 WYHGAISRGDAENLLRLCKECSYLVRNSQTSKHDYSLSLRSNQGFMHMKLAK-TKEKYVL 468
W+H +SR AENLL + +++R SQ+S D+S+S+R H K+ + K Y L
Sbjct: 58 WFHEGLSRHQAENLLMGKEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFL 117
Query: 469 GQNSPPFDSVPEVIHYYTTRKL 490
+ F S+ +++ YY T +
Sbjct: 118 W--TEKFPSLNKLVDYYRTNSI 137
>gi|166795247 phosphoinositide-3-kinase, regulatory subunit 3 (p55,
gamma) [Homo sapiens]
Length = 461
Score = 48.5 bits (114), Expect = 1e-05
Identities = 39/126 (30%), Positives = 63/126 (50%), Gaps = 5/126 (3%)
Query: 383 PIKHGSPEFCGILGERVDPAVPLEKQIWYHGAISRGDAENLLRLCKECSYLVRNSQTS-K 441
P K P + D +V L+ WY G ISR + + LR + ++LVR++ T +
Sbjct: 38 PPKPPKPMTSAVPNGMKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQ 97
Query: 442 HDYSLSLRSNQGFMHMKLAKTKEKYVLGQNSP-PFDSVPEVIHYYTTRKLPIKGAE-HLS 499
DY+L+LR +K+ KY G + P F+SV E+I++Y L + +
Sbjct: 98 GDYTLTLRKGGNNKLIKIYHRDGKY--GFSDPLTFNSVVELINHYHHESLAQYNPKLDVK 155
Query: 500 LLYPVA 505
L+YPV+
Sbjct: 156 LMYPVS 161
Score = 35.0 bits (79), Expect = 0.16
Identities = 26/100 (26%), Positives = 50/100 (50%), Gaps = 2/100 (2%)
Query: 406 EKQIWYHGAISRGDAENLLRLCKECSYLVRNSQTSKHDYSLSLRSNQGFMHMKLAKTKEK 465
+++ W+ I+R AE+LL + ++L+R S + K Y+ S+ ++ H + T
Sbjct: 354 DEKTWFVEDINRVQAEDLLYGKPDGAFLIRES-SKKGCYACSVVADGEVKHCVIYSTARG 412
Query: 466 YVLGQNSPPFDSVPE-VIHYYTTRKLPIKGAEHLSLLYPV 504
Y + + S+ E V+HY T + + ++ L YPV
Sbjct: 413 YGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPV 452
>gi|166795245 phosphoinositide-3-kinase, regulatory subunit 3 (p55,
gamma) [Homo sapiens]
Length = 461
Score = 48.5 bits (114), Expect = 1e-05
Identities = 39/126 (30%), Positives = 63/126 (50%), Gaps = 5/126 (3%)
Query: 383 PIKHGSPEFCGILGERVDPAVPLEKQIWYHGAISRGDAENLLRLCKECSYLVRNSQTS-K 441
P K P + D +V L+ WY G ISR + + LR + ++LVR++ T +
Sbjct: 38 PPKPPKPMTSAVPNGMKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQ 97
Query: 442 HDYSLSLRSNQGFMHMKLAKTKEKYVLGQNSP-PFDSVPEVIHYYTTRKLPIKGAE-HLS 499
DY+L+LR +K+ KY G + P F+SV E+I++Y L + +
Sbjct: 98 GDYTLTLRKGGNNKLIKIYHRDGKY--GFSDPLTFNSVVELINHYHHESLAQYNPKLDVK 155
Query: 500 LLYPVA 505
L+YPV+
Sbjct: 156 LMYPVS 161
Score = 35.0 bits (79), Expect = 0.16
Identities = 26/100 (26%), Positives = 50/100 (50%), Gaps = 2/100 (2%)
Query: 406 EKQIWYHGAISRGDAENLLRLCKECSYLVRNSQTSKHDYSLSLRSNQGFMHMKLAKTKEK 465
+++ W+ I+R AE+LL + ++L+R S + K Y+ S+ ++ H + T
Sbjct: 354 DEKTWFVEDINRVQAEDLLYGKPDGAFLIRES-SKKGCYACSVVADGEVKHCVIYSTARG 412
Query: 466 YVLGQNSPPFDSVPE-VIHYYTTRKLPIKGAEHLSLLYPV 504
Y + + S+ E V+HY T + + ++ L YPV
Sbjct: 413 YGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPV 452
>gi|33356177 protein tyrosine phosphatase, non-receptor type 11
[Homo sapiens]
Length = 593
Score = 48.1 bits (113), Expect = 2e-05
Identities = 31/98 (31%), Positives = 53/98 (54%), Gaps = 4/98 (4%)
Query: 410 WYHGAISRGDAENLLRLCK-ECSYLVRNSQTSKHDYSLSLRSNQGFMHMKLAKTKEKYVL 468
W+H I+ +AENLL + S+L R S+++ D++LS+R N H+K+ T + Y L
Sbjct: 6 WFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDL 65
Query: 469 GQNSPPFDSVPEVIHYYTTR--KLPIKGAEHLSLLYPV 504
F ++ E++ YY +L K + + L YP+
Sbjct: 66 -YGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPL 102
Score = 41.6 bits (96), Expect = 0.002
Identities = 30/87 (34%), Positives = 46/87 (52%), Gaps = 12/87 (13%)
Query: 410 WYHGAISRGDAENLL-RLCKECSYLVRNSQTSKHDYSLSLR-------SNQG---FMHMK 458
W+HG +S +AE LL K S+LVR SQ+ D+ LS+R SN G H+
Sbjct: 112 WFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVM 171
Query: 459 LAKTKEKYVLGQNSPPFDSVPEVIHYY 485
+ + KY +G FDS+ +++ +Y
Sbjct: 172 IRCQELKYDVG-GGERFDSLTDLVEHY 197
>gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]
Length = 1512
Score = 48.1 bits (113), Expect = 2e-05
Identities = 89/393 (22%), Positives = 143/393 (36%), Gaps = 62/393 (15%)
Query: 28 REQRRRGERPSQPPQAVP---------------------QASSAASASCGPATASCFSAS 66
R +RRR P QPP +P ++AA+A+ A++SCFS
Sbjct: 25 RRKRRRFLSPQQPPLLLPLLQPQLLQPPPPPPPLLFLAAPGTAAAAAAAAAASSSCFSP- 83
Query: 67 SGSLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGEP--GGV 124
G + RA QK R P G + R++ ++ + GG G GGV
Sbjct: 84 -GPPLEVKRLARGKRRAGGRQKRR--RGPRAGQEAEKRRVFSLPQPQQDGGGGASSGGGV 140
Query: 125 Q-----RAFSASSASG-------AAGCCCASSGAGAAASSSSSSGSPHLYRSSSERRPAT 172
S+ S G AA A+ G G + S +SS SERRP
Sbjct: 141 TPLVEYEDVSSQSEQGLLLGGASAATAATAAGGTGGSGGSPASSSGTQRRGEGSERRPRR 200
Query: 173 P--AEVRYISPKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAE 230
+ +HR + GG+ ++ S + G++ + ++
Sbjct: 201 DRRSSSGRSKERHREHRRRDGQRGGS--------EASKSRSRHSHSGEERAEVAKSGSSS 252
Query: 231 ESGAGKKDKVTIADDYSDPFDAKNDLKSKAGKGESAGYMEPYEAQRIMTEFQRQESVRSQ 290
SG +K A S ++ D SKA + + EP A + + R++ +++
Sbjct: 253 SSGGRRKS----ASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYRED--KTE 306
Query: 291 HKGIQLYDTPYEPEGQSVDSDSESTVSPRLRESKLPQDDDRPADEYDQ-----PWEWNRV 345
K + + P G DS S LR K P + Y + P ++R
Sbjct: 307 PKAYRRRRS-LSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSPSPYSRR 365
Query: 346 TIPALAAQFNGNEKRQSSPSP-SRDRRRQLRAP 377
P+ + + SPSP S R+ R+P
Sbjct: 366 RSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSP 398
>gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens]
Length = 1452
Score = 48.1 bits (113), Expect = 2e-05
Identities = 89/393 (22%), Positives = 143/393 (36%), Gaps = 62/393 (15%)
Query: 28 REQRRRGERPSQPPQAVP---------------------QASSAASASCGPATASCFSAS 66
R +RRR P QPP +P ++AA+A+ A++SCFS
Sbjct: 25 RRKRRRFLSPQQPPLLLPLLQPQLLQPPPPPPPLLFLAAPGTAAAAAAAAAASSSCFSP- 83
Query: 67 SGSLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGEP--GGV 124
G + RA QK R P G + R++ ++ + GG G GGV
Sbjct: 84 -GPPLEVKRLARGKRRAGGRQKRR--RGPRAGQEAEKRRVFSLPQPQQDGGGGASSGGGV 140
Query: 125 Q-----RAFSASSASG-------AAGCCCASSGAGAAASSSSSSGSPHLYRSSSERRPAT 172
S+ S G AA A+ G G + S +SS SERRP
Sbjct: 141 TPLVEYEDVSSQSEQGLLLGGASAATAATAAGGTGGSGGSPASSSGTQRRGEGSERRPRR 200
Query: 173 P--AEVRYISPKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAE 230
+ +HR + GG+ ++ S + G++ + ++
Sbjct: 201 DRRSSSGRSKERHREHRRRDGQRGGS--------EASKSRSRHSHSGEERAEVAKSGSSS 252
Query: 231 ESGAGKKDKVTIADDYSDPFDAKNDLKSKAGKGESAGYMEPYEAQRIMTEFQRQESVRSQ 290
SG +K A S ++ D SKA + + EP A + + R++ +++
Sbjct: 253 SSGGRRKS----ASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYRED--KTE 306
Query: 291 HKGIQLYDTPYEPEGQSVDSDSESTVSPRLRESKLPQDDDRPADEYDQ-----PWEWNRV 345
K + + P G DS S LR K P + Y + P ++R
Sbjct: 307 PKAYRRRRS-LSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSPSPYSRR 365
Query: 346 TIPALAAQFNGNEKRQSSPSP-SRDRRRQLRAP 377
P+ + + SPSP S R+ R+P
Sbjct: 366 RSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSP 398
>gi|216547801 SH2 domain containing 3C isoform e [Homo sapiens]
Length = 700
Score = 47.0 bits (110), Expect = 4e-05
Identities = 32/109 (29%), Positives = 50/109 (45%), Gaps = 13/109 (11%)
Query: 405 LEKQIWYHGAISRGDAENLLRLCKECSYLVRNSQTSKHDYSLSLRSNQGFMHMKLAK--- 461
L WYHG I R +E L++ + +L+R+S TS DY L+ R +H K+ K
Sbjct: 55 LRSHAWYHGRIPREVSETLVQ--RNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVV 112
Query: 462 ------TKEKYVLGQNSPPFDSVPEVIHYYTTRKLPIKGAEHLSLLYPV 504
T +Y+ Q S FD VP ++ Y+ + + + PV
Sbjct: 113 KAGESYTHIQYLFEQES--FDHVPALVRYHVGSRKAVSEQSGAIIYCPV 159
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.129 0.386
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,573,003
Number of Sequences: 37866
Number of extensions: 1293754
Number of successful extensions: 9251
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 159
Number of HSP's successfully gapped in prelim test: 369
Number of HSP's that attempted gapping in prelim test: 7344
Number of HSP's gapped (non-prelim): 1512
length of query: 509
length of database: 18,247,518
effective HSP length: 107
effective length of query: 402
effective length of database: 14,195,856
effective search space: 5706734112
effective search space used: 5706734112
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.