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Search of human proteins with 105990541
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|105990541 ATP-binding cassette, sub-family A member 4 [Homo
sapiens]
(2273 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|105990541 ATP-binding cassette, sub-family A member 4 [Homo s... 4612 0.0
gi|21536376 ATP-binding cassette, sub-family A member 1 [Homo sa... 2239 0.0
gi|150417984 ATP-binding cassette, sub-family A, member 7 [Homo ... 1743 0.0
gi|45446740 ATP-binding cassette, sub-family A, member 2 isoform... 1360 0.0
gi|47078218 ATP-binding cassette, sub-family A, member 2 isoform... 1360 0.0
gi|27881501 ATP-binding cassette, sub-family A, member 12 isofor... 1119 0.0
gi|30795238 ATP-binding cassette, sub-family A, member 12 isofor... 1119 0.0
gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13... 1036 0.0
gi|116734710 ATP-binding cassette, sub-family A member 3 [Homo s... 527 e-149
gi|27262624 ATP-binding cassette, sub-family A , member 5 [Homo ... 273 1e-72
gi|27262626 ATP-binding cassette, sub-family A , member 5 [Homo ... 273 1e-72
gi|27436953 ATP-binding cassette, sub-family A, member 6 [Homo s... 267 1e-70
gi|27477115 ATP-binding cassette, sub-family A, member 9 [Homo s... 259 2e-68
gi|153792144 ATP-binding cassette, sub-family A, member 10 [Homo... 250 1e-65
gi|6005701 ATP-binding cassette, sub-family A member 8 [Homo sap... 224 6e-58
gi|169210363 PREDICTED: similar to hCG18626 [Homo sapiens] 165 5e-40
gi|169210679 PREDICTED: similar to hCG18626 [Homo sapiens] 165 5e-40
gi|169209894 PREDICTED: similar to hCG18626 [Homo sapiens] 165 5e-40
gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo ... 91 1e-17
gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo ... 91 2e-17
gi|46592978 ATP-binding cassette sub-family G member 1 isoform 7... 90 2e-17
gi|46592971 ATP-binding cassette sub-family G member 1 isoform 6... 90 2e-17
gi|46592964 ATP-binding cassette sub-family G member 1 isoform 5... 90 2e-17
gi|46592956 ATP-binding cassette sub-family G member 1 isoform 3... 90 2e-17
gi|46592915 ATP-binding cassette sub-family G member 1 isoform 4... 90 2e-17
gi|46592898 ATP-binding cassette sub-family G member 1 isoform 2... 90 2e-17
gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo ... 87 1e-16
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 87 2e-16
gi|215820660 ATP-binding cassette, subfamily G, member 4 [Homo s... 87 2e-16
gi|20143975 ATP-binding cassette, subfamily G, member 4 [Homo sa... 87 2e-16
>gi|105990541 ATP-binding cassette, sub-family A member 4 [Homo
sapiens]
Length = 2273
Score = 4612 bits (11962), Expect = 0.0
Identities = 2273/2273 (100%), Positives = 2273/2273 (100%)
Query: 1 MGFVRQIQLLLWKNWTLRKRQKIRFVVELVWPLSLFLVLIWLRNANPLYSHHECHFPNKA 60
MGFVRQIQLLLWKNWTLRKRQKIRFVVELVWPLSLFLVLIWLRNANPLYSHHECHFPNKA
Sbjct: 1 MGFVRQIQLLLWKNWTLRKRQKIRFVVELVWPLSLFLVLIWLRNANPLYSHHECHFPNKA 60
Query: 61 MPSAGMLPWLQGIFCNVNNPCFQSPTPGESPGIVSNYNNSILARVYRDFQELLMNAPESQ 120
MPSAGMLPWLQGIFCNVNNPCFQSPTPGESPGIVSNYNNSILARVYRDFQELLMNAPESQ
Sbjct: 61 MPSAGMLPWLQGIFCNVNNPCFQSPTPGESPGIVSNYNNSILARVYRDFQELLMNAPESQ 120
Query: 121 HLGRIWTELHILSQFMDTLRTHPERIAGRGIRIRDILKDEETLTLFLIKNIGLSDSVVYL 180
HLGRIWTELHILSQFMDTLRTHPERIAGRGIRIRDILKDEETLTLFLIKNIGLSDSVVYL
Sbjct: 121 HLGRIWTELHILSQFMDTLRTHPERIAGRGIRIRDILKDEETLTLFLIKNIGLSDSVVYL 180
Query: 181 LINSQVRPEQFAHGVPDLALKDIACSEALLERFIIFSQRRGAKTVRYALCSLSQGTLQWI 240
LINSQVRPEQFAHGVPDLALKDIACSEALLERFIIFSQRRGAKTVRYALCSLSQGTLQWI
Sbjct: 181 LINSQVRPEQFAHGVPDLALKDIACSEALLERFIIFSQRRGAKTVRYALCSLSQGTLQWI 240
Query: 241 EDTLYANVDFFKLFRVLPTLLDSRSQGINLRSWGGILSDMSPRIQEFIHRPSMQDLLWVT 300
EDTLYANVDFFKLFRVLPTLLDSRSQGINLRSWGGILSDMSPRIQEFIHRPSMQDLLWVT
Sbjct: 241 EDTLYANVDFFKLFRVLPTLLDSRSQGINLRSWGGILSDMSPRIQEFIHRPSMQDLLWVT 300
Query: 301 RPLMQNGGPETFTKLMGILSDLLCGYPEGGGSRVLSFNWYEDNNYKAFLGIDSTRKDPIY 360
RPLMQNGGPETFTKLMGILSDLLCGYPEGGGSRVLSFNWYEDNNYKAFLGIDSTRKDPIY
Sbjct: 301 RPLMQNGGPETFTKLMGILSDLLCGYPEGGGSRVLSFNWYEDNNYKAFLGIDSTRKDPIY 360
Query: 361 SYDRRTTSFCNALIQSLESNPLTKIAWRAAKPLLMGKILYTPDSPAARRILKNANSTFEE 420
SYDRRTTSFCNALIQSLESNPLTKIAWRAAKPLLMGKILYTPDSPAARRILKNANSTFEE
Sbjct: 361 SYDRRTTSFCNALIQSLESNPLTKIAWRAAKPLLMGKILYTPDSPAARRILKNANSTFEE 420
Query: 421 LEHVRKLVKAWEEVGPQIWYFFDNSTQMNMIRDTLGNPTVKDFLNRQLGEEGITAEAILN 480
LEHVRKLVKAWEEVGPQIWYFFDNSTQMNMIRDTLGNPTVKDFLNRQLGEEGITAEAILN
Sbjct: 421 LEHVRKLVKAWEEVGPQIWYFFDNSTQMNMIRDTLGNPTVKDFLNRQLGEEGITAEAILN 480
Query: 481 FLYKGPRESQADDMANFDWRDIFNITDRTLRLVNQYLECLVLDKFESYNDETQLTQRALS 540
FLYKGPRESQADDMANFDWRDIFNITDRTLRLVNQYLECLVLDKFESYNDETQLTQRALS
Sbjct: 481 FLYKGPRESQADDMANFDWRDIFNITDRTLRLVNQYLECLVLDKFESYNDETQLTQRALS 540
Query: 541 LLEENMFWAGVVFPDMYPWTSSLPPHVKYKIRMDIDVVEKTNKIKDRYWDSGPRADPVED 600
LLEENMFWAGVVFPDMYPWTSSLPPHVKYKIRMDIDVVEKTNKIKDRYWDSGPRADPVED
Sbjct: 541 LLEENMFWAGVVFPDMYPWTSSLPPHVKYKIRMDIDVVEKTNKIKDRYWDSGPRADPVED 600
Query: 601 FRYIWGGFAYLQDMVEQGITRSQVQAEAPVGIYLQQMPYPCFVDDSFMIILNRCFPIFMV 660
FRYIWGGFAYLQDMVEQGITRSQVQAEAPVGIYLQQMPYPCFVDDSFMIILNRCFPIFMV
Sbjct: 601 FRYIWGGFAYLQDMVEQGITRSQVQAEAPVGIYLQQMPYPCFVDDSFMIILNRCFPIFMV 660
Query: 661 LAWIYSVSMTVKSIVLEKELRLKETLKNQGVSNAVIWCTWFLDSFSIMSMSIFLLTIFIM 720
LAWIYSVSMTVKSIVLEKELRLKETLKNQGVSNAVIWCTWFLDSFSIMSMSIFLLTIFIM
Sbjct: 661 LAWIYSVSMTVKSIVLEKELRLKETLKNQGVSNAVIWCTWFLDSFSIMSMSIFLLTIFIM 720
Query: 721 HGRILHYSDPFILFLFLLAFSTATIMLCFLLSTFFSKASLAAACSGVIYFTLYLPHILCF 780
HGRILHYSDPFILFLFLLAFSTATIMLCFLLSTFFSKASLAAACSGVIYFTLYLPHILCF
Sbjct: 721 HGRILHYSDPFILFLFLLAFSTATIMLCFLLSTFFSKASLAAACSGVIYFTLYLPHILCF 780
Query: 781 AWQDRMTAELKKAVSLLSPVAFGFGTEYLVRFEEQGLGLQWSNIGNSPTEGDEFSFLLSM 840
AWQDRMTAELKKAVSLLSPVAFGFGTEYLVRFEEQGLGLQWSNIGNSPTEGDEFSFLLSM
Sbjct: 781 AWQDRMTAELKKAVSLLSPVAFGFGTEYLVRFEEQGLGLQWSNIGNSPTEGDEFSFLLSM 840
Query: 841 QMMLLDAAVYGLLAWYLDQVFPGDYGTPLPWYFLLQESYWLGGEGCSTREERALEKTEPL 900
QMMLLDAAVYGLLAWYLDQVFPGDYGTPLPWYFLLQESYWLGGEGCSTREERALEKTEPL
Sbjct: 841 QMMLLDAAVYGLLAWYLDQVFPGDYGTPLPWYFLLQESYWLGGEGCSTREERALEKTEPL 900
Query: 901 TEETEDPEHPEGIHDSFFEREHPGWVPGVCVKNLVKIFEPCGRPAVDRLNITFYENQITA 960
TEETEDPEHPEGIHDSFFEREHPGWVPGVCVKNLVKIFEPCGRPAVDRLNITFYENQITA
Sbjct: 901 TEETEDPEHPEGIHDSFFEREHPGWVPGVCVKNLVKIFEPCGRPAVDRLNITFYENQITA 960
Query: 961 FLGHNGAGKTTTLSILTGLLPPTSGTVLVGGRDIETSLDAVRQSLGMCPQHNILFHHLTV 1020
FLGHNGAGKTTTLSILTGLLPPTSGTVLVGGRDIETSLDAVRQSLGMCPQHNILFHHLTV
Sbjct: 961 FLGHNGAGKTTTLSILTGLLPPTSGTVLVGGRDIETSLDAVRQSLGMCPQHNILFHHLTV 1020
Query: 1021 AEHMLFYAQLKGKSQEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVAIAFVGDA 1080
AEHMLFYAQLKGKSQEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVAIAFVGDA
Sbjct: 1021 AEHMLFYAQLKGKSQEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVAIAFVGDA 1080
Query: 1081 KVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIAIIAQGRLYC 1140
KVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIAIIAQGRLYC
Sbjct: 1081 KVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIAIIAQGRLYC 1140
Query: 1141 SGTPLFLKNCFGTGLYLTLVRKMKNIQSQRKGSEGTCSCSSKGFSTTCPAHVDDLTPEQV 1200
SGTPLFLKNCFGTGLYLTLVRKMKNIQSQRKGSEGTCSCSSKGFSTTCPAHVDDLTPEQV
Sbjct: 1141 SGTPLFLKNCFGTGLYLTLVRKMKNIQSQRKGSEGTCSCSSKGFSTTCPAHVDDLTPEQV 1200
Query: 1201 LDGDVNELMDVVLHHVPEAKLVECIGQELIFLLPNKNFKHRAYASLFRELEETLADLGLS 1260
LDGDVNELMDVVLHHVPEAKLVECIGQELIFLLPNKNFKHRAYASLFRELEETLADLGLS
Sbjct: 1201 LDGDVNELMDVVLHHVPEAKLVECIGQELIFLLPNKNFKHRAYASLFRELEETLADLGLS 1260
Query: 1261 SFGISDTPLEEIFLKVTEDSDSGPLFAGGAQQKRENVNPRHPCLGPREKAGQTPQDSNVC 1320
SFGISDTPLEEIFLKVTEDSDSGPLFAGGAQQKRENVNPRHPCLGPREKAGQTPQDSNVC
Sbjct: 1261 SFGISDTPLEEIFLKVTEDSDSGPLFAGGAQQKRENVNPRHPCLGPREKAGQTPQDSNVC 1320
Query: 1321 SPGAPAAHPEGQPPPEPECPGPQLNTGTQLVLQHVQALLVKRFQHTIRSHKDFLAQIVLP 1380
SPGAPAAHPEGQPPPEPECPGPQLNTGTQLVLQHVQALLVKRFQHTIRSHKDFLAQIVLP
Sbjct: 1321 SPGAPAAHPEGQPPPEPECPGPQLNTGTQLVLQHVQALLVKRFQHTIRSHKDFLAQIVLP 1380
Query: 1381 ATFVFLALMLSIVIPPFGEYPALTLHPWIYGQQYTFFSMDEPGSEQFTVLADVLLNKPGF 1440
ATFVFLALMLSIVIPPFGEYPALTLHPWIYGQQYTFFSMDEPGSEQFTVLADVLLNKPGF
Sbjct: 1381 ATFVFLALMLSIVIPPFGEYPALTLHPWIYGQQYTFFSMDEPGSEQFTVLADVLLNKPGF 1440
Query: 1441 GNRCLKEGWLPEYPCGNSTPWKTPSVSPNITQLFQKQKWTQVNPSPSCRCSTREKLTMLP 1500
GNRCLKEGWLPEYPCGNSTPWKTPSVSPNITQLFQKQKWTQVNPSPSCRCSTREKLTMLP
Sbjct: 1441 GNRCLKEGWLPEYPCGNSTPWKTPSVSPNITQLFQKQKWTQVNPSPSCRCSTREKLTMLP 1500
Query: 1501 ECPEGAGGLPPPQRTQRSTEILQDLTDRNISDFLVKTYPALIRSSLKSKFWVNEQRYGGI 1560
ECPEGAGGLPPPQRTQRSTEILQDLTDRNISDFLVKTYPALIRSSLKSKFWVNEQRYGGI
Sbjct: 1501 ECPEGAGGLPPPQRTQRSTEILQDLTDRNISDFLVKTYPALIRSSLKSKFWVNEQRYGGI 1560
Query: 1561 SIGGKLPVVPITGEALVGFLSDLGRIMNVSGGPITREASKEIPDFLKHLETEDNIKVWFN 1620
SIGGKLPVVPITGEALVGFLSDLGRIMNVSGGPITREASKEIPDFLKHLETEDNIKVWFN
Sbjct: 1561 SIGGKLPVVPITGEALVGFLSDLGRIMNVSGGPITREASKEIPDFLKHLETEDNIKVWFN 1620
Query: 1621 NKGWHALVSFLNVAHNAILRASLPKDRSPEEYGITVISQPLNLTKEQLSEITVLTTSVDA 1680
NKGWHALVSFLNVAHNAILRASLPKDRSPEEYGITVISQPLNLTKEQLSEITVLTTSVDA
Sbjct: 1621 NKGWHALVSFLNVAHNAILRASLPKDRSPEEYGITVISQPLNLTKEQLSEITVLTTSVDA 1680
Query: 1681 VVAICVIFSMSFVPASFVLYLIQERVNKSKHLQFISGVSPTTYWVTNFLWDIMNYSVSAG 1740
VVAICVIFSMSFVPASFVLYLIQERVNKSKHLQFISGVSPTTYWVTNFLWDIMNYSVSAG
Sbjct: 1681 VVAICVIFSMSFVPASFVLYLIQERVNKSKHLQFISGVSPTTYWVTNFLWDIMNYSVSAG 1740
Query: 1741 LVVGIFIGFQKKAYTSPENLPALVALLLLYGWAVIPMMYPASFLFDVPSTAYVALSCANL 1800
LVVGIFIGFQKKAYTSPENLPALVALLLLYGWAVIPMMYPASFLFDVPSTAYVALSCANL
Sbjct: 1741 LVVGIFIGFQKKAYTSPENLPALVALLLLYGWAVIPMMYPASFLFDVPSTAYVALSCANL 1800
Query: 1801 FIGINSSAITFILELFENNRTLLRFNAVLRKLLIVFPHFCLGRGLIDLALSQAVTDVYAR 1860
FIGINSSAITFILELFENNRTLLRFNAVLRKLLIVFPHFCLGRGLIDLALSQAVTDVYAR
Sbjct: 1801 FIGINSSAITFILELFENNRTLLRFNAVLRKLLIVFPHFCLGRGLIDLALSQAVTDVYAR 1860
Query: 1861 FGEEHSANPFHWDLIGKNLFAMVVEGVVYFLLTLLVQRHFFLSQWIAEPTKEPIVDEDDD 1920
FGEEHSANPFHWDLIGKNLFAMVVEGVVYFLLTLLVQRHFFLSQWIAEPTKEPIVDEDDD
Sbjct: 1861 FGEEHSANPFHWDLIGKNLFAMVVEGVVYFLLTLLVQRHFFLSQWIAEPTKEPIVDEDDD 1920
Query: 1921 VAEERQRIITGGNKTDILRLHELTKIYPGTSSPAVDRLCVGVRPGECFGLLGVNGAGKTT 1980
VAEERQRIITGGNKTDILRLHELTKIYPGTSSPAVDRLCVGVRPGECFGLLGVNGAGKTT
Sbjct: 1921 VAEERQRIITGGNKTDILRLHELTKIYPGTSSPAVDRLCVGVRPGECFGLLGVNGAGKTT 1980
Query: 1981 TFKMLTGDTTVTSGDATVAGKSILTNISEVHQNMGYCPQFDAIDELLTGREHLYLYARLR 2040
TFKMLTGDTTVTSGDATVAGKSILTNISEVHQNMGYCPQFDAIDELLTGREHLYLYARLR
Sbjct: 1981 TFKMLTGDTTVTSGDATVAGKSILTNISEVHQNMGYCPQFDAIDELLTGREHLYLYARLR 2040
Query: 2041 GVPAEEIEKVANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTG 2100
GVPAEEIEKVANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTG
Sbjct: 2041 GVPAEEIEKVANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTG 2100
Query: 2101 MDPQARRMLWNVIVSIIREGRAVVLTSHSMEECEALCTRLAIMVKGAFRCMGTIQHLKSK 2160
MDPQARRMLWNVIVSIIREGRAVVLTSHSMEECEALCTRLAIMVKGAFRCMGTIQHLKSK
Sbjct: 2101 MDPQARRMLWNVIVSIIREGRAVVLTSHSMEECEALCTRLAIMVKGAFRCMGTIQHLKSK 2160
Query: 2161 FGDGYIVTMKIKSPKDDLLPDLNPVEQFFQGNFPGSVQRERHYNMLQFQVSSSSLARIFQ 2220
FGDGYIVTMKIKSPKDDLLPDLNPVEQFFQGNFPGSVQRERHYNMLQFQVSSSSLARIFQ
Sbjct: 2161 FGDGYIVTMKIKSPKDDLLPDLNPVEQFFQGNFPGSVQRERHYNMLQFQVSSSSLARIFQ 2220
Query: 2221 LLLSHKDSLLIEEYSVTQTTLDQVFVNFAKQQTESHDLPLHPRAAGASRQAQD 2273
LLLSHKDSLLIEEYSVTQTTLDQVFVNFAKQQTESHDLPLHPRAAGASRQAQD
Sbjct: 2221 LLLSHKDSLLIEEYSVTQTTLDQVFVNFAKQQTESHDLPLHPRAAGASRQAQD 2273
>gi|21536376 ATP-binding cassette, sub-family A member 1 [Homo
sapiens]
Length = 2261
Score = 2239 bits (5802), Expect = 0.0
Identities = 1151/2276 (50%), Positives = 1515/2276 (66%), Gaps = 65/2276 (2%)
Query: 6 QIQLLLWKNWTLRKRQKIRFVVELVWPLSLFLVLIWLRNANPLYSHHECHFPNKAMPSAG 65
Q++LLLWKN T R+RQ + ++E+ WPL +FL+LI +R + P Y HECHFPNKAMPSAG
Sbjct: 6 QLRLLLWKNLTFRRRQTCQLLLEVAWPLFIFLILISVRLSYPPYEQHECHFPNKAMPSAG 65
Query: 66 MLPWLQGIFCNVNNPCFQSPTPGESPGIVSNYNNSILARVYRDFQELLMNAPESQHLGRI 125
LPW+QGI CN NNPCF+ PTPGE+PG+V N+N SI+AR++ D + LL+ + + + +
Sbjct: 66 TLPWVQGIICNANNPCFRYPTPGEAPGVVGNFNKSIVARLFSDARRLLLYSQKDTSMKDM 125
Query: 126 WTELHILSQFMDTLRTHPERIAGRGIRIRDILKDEETLTLFLIKNIGLSDSVVYLLINSQ 185
L L Q + + ++++D L D ET + FL N+ L S V ++ +
Sbjct: 126 RKVLRTLQQI---------KKSSSNLKLQDFLVDNETFSGFLYHNLSLPKSTVDKMLRAD 176
Query: 186 VRPEQFAHGVPDLALKDIACSEALLERFIIFSQRRGAKTVRYALCSLSQGTLQWIEDTLY 245
V + L L + C+ + E I + ++ LC L + L E L
Sbjct: 177 VILHKVFLQGYQLHLTSL-CNGSKSEEMIQLGDQEVSE-----LCGLPREKLAAAERVLR 230
Query: 246 ANVDFFK-LFRVLPTLLDSRSQGINLRSWGGILSDMSPRIQEFIHRPSMQDLLWVTRPLM 304
+N+D K + R L + S+ + + +L + QE S D+ L
Sbjct: 231 SNMDILKPILRTLNSTSPFPSKEL-AEATKTLLHSLGTLAQELFSMRSWSDMRQEVMFLT 289
Query: 305 QNGGPETFTKLMGILSDLLCGYPEGGGSRVLSFNWYEDNNYKAFLGIDSTRKDPIYSYDR 364
+ T++ +S ++CG+PEGGG ++ S NWYEDNNYKA G + T +D YD
Sbjct: 290 NVNSSSSSTQIYQAVSRIVCGHPEGGGLKIKSLNWYEDNNYKALFGGNGTEEDAETFYDN 349
Query: 365 RTTSFCNALIQSLESNPLTKIAWRAAKPLLMGKILYTPDSPAARRILKNANSTFEELEHV 424
TT +CN L+++LES+PL++I W+A KPLL+GKILYTPD+PA R+++ N TF+EL
Sbjct: 350 STTPYCNDLMKNLESSPLSRIIWKALKPLLVGKILYTPDTPATRQVMAEVNKTFQELAVF 409
Query: 425 RKLVKAWEEVGPQIWYFFDNSTQMNMIRDTLGNPTVKDFLNRQLGEEGITAEAILNFLYK 484
L WEE+ P+IW F +NS +M+++R L + F +QL TA+ I+ FL K
Sbjct: 410 HDLEGMWEELSPKIWTFMENSQEMDLVRMLLDSRDNDHFWEQQLDGLDWTAQDIVAFLAK 469
Query: 485 GPRESQADDMANFDWRDIFNITDRTLRLVNQYLECLVLDKFESYNDETQLTQRALSLLEE 544
P + Q+ + + + WR+ FN T++ +R +++++EC+ L+K E E L +++ LL+E
Sbjct: 470 HPEDVQSSNGSVYTWREAFNETNQAIRTISRFMECVNLNKLEPIATEVWLINKSMELLDE 529
Query: 545 NMFWAGVVFPDMYPWTSSLPPHVKYKIRMDIDVVEKTNKIKDRYWDSGPRADPVEDFRYI 604
FWAG+VF + P + LP HVKYKIRMDID VE+TNKIKD YWD GPRADP ED RY+
Sbjct: 530 RKFWAGIVFTGITPGSIELPHHVKYKIRMDIDNVERTNKIKDGYWDPGPRADPFEDMRYV 589
Query: 605 WGGFAYLQDMVEQGITRSQVQAEAPVGIYLQQMPYPCFVDDSFMIILNRCFPIFMVLAWI 664
WGGFAYLQD+VEQ I R E G+Y+QQMPYPC+VDD F+ +++R P+FM LAWI
Sbjct: 590 WGGFAYLQDVVEQAIIRVLTGTEKKTGVYMQQMPYPCYVDDIFLRVMSRSMPLFMTLAWI 649
Query: 665 YSVSMTVKSIVLEKELRLKETLKNQGVSNAVIWCTWFLDSFSIMSMSIFLLTIFIMHGRI 724
YSV++ +K IV EKE RLKET++ G+ N+++W +WF+ S + +S LL + + G +
Sbjct: 650 YSVAVIIKGIVYEKEARLKETMRIMGLDNSILWFSWFISSLIPLLVSAGLLVVILKLGNL 709
Query: 725 LHYSDPFILFLFLLAFSTATIMLCFLLSTFFSKASLAAACSGVIYFTLYLPHILCFAWQD 784
L YSDP ++F+FL F+ TI+ CFL+ST FS+A+LAAAC G+IYFTLYLP++LC AWQD
Sbjct: 710 LPYSDPSVVFVFLSVFAVVTILQCFLISTLFSRANLAAACGGIIYFTLYLPYVLCVAWQD 769
Query: 785 RMTAELKKAVSLLSPVAFGFGTEYLVRFEEQGLGLQWSNIGNSPTEGDEFSFLLSMQMML 844
+ LK SLLSPVAFGFG EY FEEQG+G+QW N+ SP E D F+ S+ MML
Sbjct: 770 YVGFTLKIFASLLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNLTTSVSMML 829
Query: 845 LDAAVYGLLAWYLDQVFPGDYGTPLPWYFLLQESYWLGGEGCSTREERALEKTEPLTEET 904
D +YG++ WY++ VFPG YG P PWYF +SYW G EE+
Sbjct: 830 FDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFG-------------------EES 870
Query: 905 EDPEHP----EGIHDSFFEREHPGWVPGVCVKNLVKIFEPCGRPAVDRLNITFYENQITA 960
++ HP + I + E E GV ++NLVK++ + AVD L + FYE QIT+
Sbjct: 871 DEKSHPGSNQKRISEICMEEEPTHLKLGVSIQNLVKVYRDGMKVAVDGLALNFYEGQITS 930
Query: 961 FLGHNGAGKTTTLSILTGLLPPTSGTVLVGGRDIETSLDAVRQSLGMCPQHNILFHHLTV 1020
FLGHNGAGKTTT+SILTGL PPTSGT + G+DI + + +RQ+LG+CPQHN+LF LTV
Sbjct: 931 FLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEMSTIRQNLGVCPQHNVLFDMLTV 990
Query: 1021 AEHMLFYAQLKGKSQEEAQLEMEAMLEDTGL-HHKRNEEAQDLSGGMQRKLSVAIAFVGD 1079
EH+ FYA+LKG S++ + EME M D GL K + LSGGMQRKLSVA+AFVG
Sbjct: 991 EEHIWFYARLKGLSEKHVKAEMEQMALDVGLPSSKLKSKTSQLSGGMQRKLSVALAFVGG 1050
Query: 1080 AKVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIAIIAQGRLY 1139
+KVVILDEPT+GVDPYSRR IW+LLLKYR GRTII+STHHMDEAD+LGDRIAII+ G+L
Sbjct: 1051 SKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADVLGDRIAIISHGKLC 1110
Query: 1140 CSGTPLFLKNCFGTGLYLTLVRK-MKNIQSQRKGSEGTCSCSSKGFS---TTCPAHVDDL 1195
C G+ LFLKN GTG YLTLV+K +++ S + S T S K S ++ A +
Sbjct: 1111 CVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSYLKKEDSVSQSSSDAGLGSD 1170
Query: 1196 TPEQVLDGDVNELMDVVLHHVPEAKLVECIGQELIFLLPNKNFKHRAYASLFRELEETLA 1255
L DV+ + +++ HV EA+LVE IG EL ++LP + K A+ LF E+++ L+
Sbjct: 1171 HESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAKEGAFVELFHEIDDRLS 1230
Query: 1256 DLGLSSFGISDTPLEEIFLKVTEDSDSGPLFAGG---AQQKRENVNPRHPCLGP-REKAG 1311
DLG+SS+GIS+T LEEIFLKV E+S + G A++ R + CL P E
Sbjct: 1231 DLGISSYGISETTLEEIFLKVAEESGVDAETSDGTLPARRNRRAFGDKQSCLRPFTEDDA 1290
Query: 1312 QTPQDSNVCSPGAPAAHPEGQPPPEPECPGPQLNTGTQLVLQHVQALLVKRFQHTIRSHK 1371
P DS++ G + G G +L Q ALL KR RS K
Sbjct: 1291 ADPNDSDIDPESRETDLLSGM-----DGKGSYQVKGWKLTQQQFVALLWKRLLIARRSRK 1345
Query: 1372 DFLAQIVLPATFVFLALMLSIVIPPFGEYPALTLHPWIYGQQYTFFSMDEPGSEQFTVLA 1431
F AQIVLPA FV +AL+ S+++PPFG+YP+L L PW+Y +QYTF S D P L
Sbjct: 1346 GFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQPWMYNEQYTFVSNDAPEDTGTLELL 1405
Query: 1432 DVLLNKPGFGNRCLKEGWLPEYPC-GNSTPWKTPSVSPNITQLFQKQKWTQVNPSPSCRC 1490
+ L PGFG RC++ +P+ PC W T V I LFQ WT NPSP+C+C
Sbjct: 1406 NALTKDPGFGTRCMEGNPIPDTPCQAGEEEWTTAPVPQTIMDLFQNGNWTMQNPSPACQC 1465
Query: 1491 STREKLTMLPECPEGAGGLPPPQRTQRSTEILQDLTDRNISDFLVKTYPALIRSSLKSKF 1550
S+ + MLP CP GAGGLPPPQR Q + +ILQDLT RNISD+LVKTY +I SLK+K
Sbjct: 1466 SSDKIKKMLPVCPPGAGGLPPPQRKQNTADILQDLTGRNISDYLVKTYVQIIAKSLKNKI 1525
Query: 1551 WVNEQRYGGISIGGKLPVVPITGEALVGFLSDLGRIMNVSGGPITREASKEIPDFLKHLE 1610
WVNE RYGG S+G + + + + + + ++ + F+ L+
Sbjct: 1526 WVNEFRYGGFSLGVSNTQALPPSQEVNDAIKQMKKHLKLAKDSSADRFLNSLGRFMTGLD 1585
Query: 1611 TEDNIKVWFNNKGWHALVSFLNVAHNAILRASLPKDRSPEEYGITVISQPLNLTKEQLSE 1670
T++N+KVWFNNKGWHA+ SFLNV +NAILRA+L K +P YGIT + PLNLTK+QLSE
Sbjct: 1586 TKNNVKVWFNNKGWHAISSFLNVINNAILRANLQKGENPSHYGITAFNHPLNLTKQQLSE 1645
Query: 1671 ITVLTTSVDAVVAICVIFSMSFVPASFVLYLIQERVNKSKHLQFISGVSPTTYWVTNFLW 1730
+ ++TTSVD +V+ICVIF+MSFVPASFV++LIQERV+K+KHLQFISGV P YW++NF+W
Sbjct: 1646 VALMTTSVDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVW 1705
Query: 1731 DIMNYSVSAGLVVGIFIGFQKKAYTSPENLPALVALLLLYGWAVIPMMYPASFLFDVPST 1790
D+ NY V A LV+ IFI FQ+K+Y S NLP L LLLLYGW++ P+MYPASF+F +PST
Sbjct: 1706 DMCNYVVPATLVIIIFICFQQKSYVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPST 1765
Query: 1791 AYVALSCANLFIGINSSAITFILELFENNRTLLRFNAVLRKLLIVFPHFCLGRGLIDLAL 1850
AYV L+ NLFIGIN S TF+LELF +N+ L N +L+ + ++FPHFCLGRGLID+
Sbjct: 1766 AYVVLTSVNLFIGINGSVATFVLELFTDNK-LNNINDILKSVFLIFPHFCLGRGLIDMVK 1824
Query: 1851 SQAVTDVYARFGEEHSANPFHWDLIGKNLFAMVVEGVVYFLLTLLVQRHFFLSQWIAEPT 1910
+QA+ D RFGE +P WDL+G+NLFAM VEGVV+FL+T+L+Q FF+
Sbjct: 1825 NQAMADALERFGENRFVSPLSWDLVGRNLFAMAVEGVVFFLITVLIQYRFFIRPRPVNAK 1884
Query: 1911 KEPIVDEDDDVAEERQRIITGGNKTDILRLHELTKIYPGTSSPAVDRLCVGVRPGECFGL 1970
P+ DED+DV ERQRI+ GG + DIL + ELTKIY PAVDR+CVG+ PGECFGL
Sbjct: 1885 LSPLNDEDEDVRRERQRILDGGGQNDILEIKELTKIYRRKRKPAVDRICVGIPPGECFGL 1944
Query: 1971 LGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNISEVHQNMGYCPQFDAIDELLTGR 2030
LGVNGAGK++TFKMLTGDTTVT GDA + SIL+NI EVHQNMGYCPQFDAI ELLTGR
Sbjct: 1945 LGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDAITELLTGR 2004
Query: 2031 EHLYLYARLRGVPAEEIEKVANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAIALIGCPP 2090
EH+ +A LRGVP +E+ KV W+I+ LGL Y + AG YSGGNKRKLSTA+ALIG PP
Sbjct: 2005 EHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTAMALIGGPP 2064
Query: 2091 LVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSHSMEECEALCTRLAIMVKGAFRC 2150
+V LDEPTTGMDP+ARR LWN +S+++EGR+VVLTSHSMEECEALCTR+AIMV G FRC
Sbjct: 2065 VVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRC 2124
Query: 2151 MGTIQHLKSKFGDGYIVTMKIKSPKDDLLPDLNPVEQFFQGNFPGSVQRERHYNMLQFQV 2210
+G++QHLK++FGDGY + ++I PDL PV+ FF FPGSV +E+H NMLQ+Q+
Sbjct: 2125 LGSVQHLKNRFGDGYTIVVRIAGSN----PDLKPVQDFFGLAFPGSVLKEKHRNMLQYQL 2180
Query: 2211 SS--SSLARIFQLLLSHKDSLLIEEYSVTQTTLDQVFVNFAKQQTES---HDLPLH 2261
S SSLARIF +L K L IE+YSV+QTTLDQVFVNFAK Q++ DL LH
Sbjct: 2181 PSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSDDDHLKDLSLH 2236
>gi|150417984 ATP-binding cassette, sub-family A, member 7 [Homo
sapiens]
Length = 2146
Score = 1743 bits (4514), Expect = 0.0
Identities = 946/2033 (46%), Positives = 1285/2033 (63%), Gaps = 113/2033 (5%)
Query: 256 VLPTLLDSRSQGINL----RSWGGILSDMSPRIQEFIHRPSMQDLLWVTRPLMQNGGPET 311
+L +LL + S G+ L +L QE + S+ +L R L+Q P
Sbjct: 159 LLTSLLRTESLGLALGQAQEPLHSLLEAAEDLAQELLALRSLVEL----RALLQR--PRG 212
Query: 312 FTKLMGILSDLLCGYPEGGGSRVLSFNWYEDNNYKAFLGIDSTRKDPIYSYDRRTTSFCN 371
+ + +LS+ LC + S NWYE ++ +G + P D + C+
Sbjct: 213 TSGPLELLSEALCSVRGPSSTVGPSLNWYEASDLMELVGQEPESALP----DSSLSPACS 268
Query: 372 ALIQSLESNPLTKIAWRAAKPLLMGKILYTPDSPAARRILKNANSTFEELEHVRKLVKAW 431
LI +L+S+PL+++ WR KPL++GK+L+ PD+P R+++ N TFEEL +R + + W
Sbjct: 269 ELIGALDSHPLSRLLWRRLKPLILGKLLFAPDTPFTRKLMAQVNRTFEELTLLRDVREVW 328
Query: 432 EEVGPQIWYFFDNSTQMNMIRDTLGNPTVKDFLNRQLGEEGIT-AEAILNFLYKGPRESQ 490
E +GP+I+ F ++S+ + M++ L ++D RQ G EA+ +FL G
Sbjct: 329 EMLGPRIFTFMNDSSNVAMLQRLL---QMQDEGRRQPRPGGRDHMEALRSFLDPGS---- 381
Query: 491 ADDMANFDWRDIFNITDRTLRLVNQYLECLVLDKFESYNDETQLTQRALSLLEENMFWAG 550
+ W+D + + + ECL LDK E+ E L RAL LL E+ FWAG
Sbjct: 382 ----GGYSWQDAHADVGHLVGTLGRVTECLSLDKLEAAPSEAALVSRALQLLAEHRFWAG 437
Query: 551 VVF--------PDMYPWTSSLPPHVKYKIRMDIDVVEKTNKIKDRYWDSGPRADPVEDFR 602
VVF P +P P HV+ KIRMDIDVV +TNKI+DR+WD GP ADP+ D R
Sbjct: 438 VVFLGPEDSSDPTEHPTPDLGPGHVRIKIRMDIDVVTRTNKIRDRFWDPGPAADPLTDLR 497
Query: 603 YIWGGFAYLQDMVEQGITRSQVQAEAPVGIYLQQMPYPCFVDDSFMIILNRCFPIFMVLA 662
Y+WGGF YLQD+VE+ R A G+YLQQMPYPC+VDD F+ +L+R P+F+ LA
Sbjct: 498 YVWGGFVYLQDLVERAAVRVLSGANPRAGLYLQQMPYPCYVDDVFLRVLSRSLPLFLTLA 557
Query: 663 WIYSVSMTVKSIVLEKELRLKETLKNQGVSNAVIWCTWFLDSFSIMSMSIFLLTIFIMHG 722
WIYSV++TVK++V EKE RL++T++ G+S AV+W WFL +S LL + + G
Sbjct: 558 WIYSVTLTVKAVVREKETRLRDTMRAMGLSRAVLWLGWFLSCLGPFLLSAALLVLVLKLG 617
Query: 723 RILHYSDPFILFLFLLAFSTATIMLCFLLSTFFSKASLAAACSGVIYFTLYLPHILCFAW 782
IL YS P ++FLFL AF+ AT+ FLLS FFS+A+LAAAC G+ YF+LYLP++LC AW
Sbjct: 618 DILPYSHPGVVFLFLAAFAVATVTQSFLLSAFFSRANLAAACGGLAYFSLYLPYVLCVAW 677
Query: 783 QDRMTAELKKAVSLLSPVAFGFGTEYLVRFEEQGLGLQWSNIGNSPTEGDEFSFLLSMQM 842
+DR+ A + A SLLSPVAFGFG E L EEQG G QW N+G PT D FS +
Sbjct: 678 RDRLPAGGRVAASLLSPVAFGFGCESLALLEEQGEGAQWHNVGTRPT-ADVFSLAQVSGL 736
Query: 843 MLLDAAVYGLLAWYLDQVFPGDYGTPLPWYFLLQESYWLGGEGCSTREERALEKTEPLTE 902
+LLDAA+YGL WYL+ V PG YG P PW F + SYW G R + P
Sbjct: 737 LLLDAALYGLATWYLEAVCPGQYGIPEPWNFPFRRSYWCG--------PRPPKSPAPCPT 788
Query: 903 ETEDPEHPEGIHDSFFEREHPGWVPGVCVKNLVKIFEPCGRPAVDRLNITFYENQITAFL 962
DP+ E PG PGV V++L K F +PA+ L++ FY+ ITAFL
Sbjct: 789 PL-DPK-------VLVEEAPPGLSPGVSVRSLEKRFPGSPQPALRGLSLDFYQGHITAFL 840
Query: 963 GHNGAGKTTTLSILTGLLPPTSGTVLVGGRDIETSLDAVRQSLGMCPQHNILFHHLTVAE 1022
GHNGAGKTTTLSIL+GL PP+ G+ + G D+ +S+ A+R LG+CPQ+N+LF LTV E
Sbjct: 841 GHNGAGKTTTLSILSGLFPPSGGSAFILGHDVRSSMAAIRPHLGVCPQYNVLFDMLTVDE 900
Query: 1023 HMLFYAQLKGKSQEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVAIAFVGDAKV 1082
H+ FY +LKG S E + +L+D GL K++ + + LSGGMQRKLSVAIAFVG ++V
Sbjct: 901 HVWFYGRLKGLSAAVVGPEQDRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVGGSQV 960
Query: 1083 VILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIAIIAQGRLYCSG 1142
VILDEPT+GVDP SRR IW+LLLKYR GRT+I+STHH+DEA+LLGDR+A++A GRL C G
Sbjct: 961 VILDEPTAGVDPASRRGIWELLLKYREGRTLILSTHHLDEAELLGDRVAVVAGGRLCCCG 1020
Query: 1143 TPLFLKNCFGTGLYLTLVRKMKNIQSQRKGS---EGTCSCSSKGFSTTCPAHVDDLTPEQ 1199
+PLFL+ G+G YLTLV+ + + K EG+ + + + + V TP+
Sbjct: 1021 SPLFLRRHLGSGYYLTLVKARLPLTTNEKADTDMEGSVDTRQEKKNGSQGSRVG--TPQ- 1077
Query: 1200 VLDGDVNELMDVVLHHVPEAKLVECIGQELIFLLPNKNFKHRAYASLFRELEETLADLGL 1259
L+ +V H VP A+LVE + EL+ +LP ++A+LFREL+ LA+L L
Sbjct: 1078 --------LLALVQHWVPGARLVEELPHELVLVLPYTGAHDGSFATLFRELDTRLAELRL 1129
Query: 1260 SSFGISDTPLEEIFLKVTEDSDSGPLFAGGAQQKRENVNPRHPCLGPREKAG-------Q 1312
+ +GISDT LEEIFLKV E+ + G+ + H C G AG +
Sbjct: 1130 TGYGISDTSLEEIFLKVVEECAADTDMEDGSCGQ-------HLCTGI---AGLDVTLRLK 1179
Query: 1313 TPQDSNVCSPGAPAAH-PEGQPPPEPECPGPQLNTGTQLVLQHVQALLVKRFQHTIRSHK 1371
P G PA PE P+ G G L Q +QALL+KRF RS +
Sbjct: 1180 MPPQETALENGEPAGSAPETDQGSGPDAVGRV--QGWALTRQQLQALLLKRFLLARRSRR 1237
Query: 1372 DFLAQIVLPATFVFLALMLSIVIPPFGEYPALTLHPWIYGQQYTFFSMDEPGSEQFTVLA 1431
AQIVLPA FV LAL+ S+++PPFG YPAL L P +YG Q +FFS D PG L
Sbjct: 1238 GLFAQIVLPALFVGLALVFSLIVPPFGHYPALRLSPTMYGAQVSFFSEDAPGDPGRARLL 1297
Query: 1432 DVLLNKPGFGNRCLKEGWLPEYPCGNSTP-WKTPSVSPNITQLFQKQKWTQVNPSPSCRC 1490
+ LL + G L E P +S+ + P V + ++ WT +PSP+C+C
Sbjct: 1298 EALLQEAG----------LEEPPVQHSSHRFSAPEVPAEVAKVLASGNWTPESPSPACQC 1347
Query: 1491 STREKLTMLPECPEGAGGLPPPQRTQRSTEILQDLTDRNISDFLVKTYPALIRSSLKSKF 1550
S +LP+CP AGG PPPQ S E++Q+LT RN+SDFLVKTYP L+R LK+K
Sbjct: 1348 SRPGARRLLPDCPAAAGGPPPPQAVTGSGEVVQNLTGRNLSDFLVKTYPRLVRQGLKTKK 1407
Query: 1551 WVNEQRYGGISIGGKLPVVPITGEALVGFLSDLGRIMNVSGGPITREASKEIPDFLKHLE 1610
WVNE RYGG S+GG+ P +P +G+ L + +L +++ G K + + L+
Sbjct: 1408 WVNEVRYGGFSLGGRDPGLP-SGQELGRSVEELWALLSPLPGGALDRVLKNLTAWAHSLD 1466
Query: 1611 TEDNIKVWFNNKGWHALVSFLNVAHNAILRASLPKDRSPEEYGITVISQPLNLTKEQLSE 1670
+D++K+WFNNKGWH++V+F+N A NAILRA LP + + IT ++ PLNLTKEQLSE
Sbjct: 1467 AQDSLKIWFNNKGWHSMVAFVNRASNAILRAHLPPGPARHAHSITTLNHPLNLTKEQLSE 1526
Query: 1671 ITVLTTSVDAVVAICVIFSMSFVPASFVLYLIQERVNKSKHLQFISGVSPTTYWVTNFLW 1730
++ +SVD +V+ICV+F+MSFVPASF L LI+ERV ++KHLQ + G+SPT YW+ NFLW
Sbjct: 1527 GALMASSVDVLVSICVVFAMSFVPASFTLVLIEERVTRAKHLQLMGGLSPTLYWLGNFLW 1586
Query: 1731 DIMNYSVSAGLVVGIFIGFQKKAYTSPENLPALVALLLLYGWAVIPMMYPASFLFDVPST 1790
D+ NY V A +VV IF+ FQ++AY +P NLPAL+ LLLLYGW++ P+MYPASF F VPST
Sbjct: 1587 DMCNYLVPACIVVLIFLAFQQRAYVAPANLPALLLLLLLYGWSITPLMYPASFFFSVPST 1646
Query: 1791 AYVALSCANLFIGINSSAITFILELFENNRTLLRFNAVLRKLLIVFPHFCLGRGLIDLAL 1850
AYV L+C NLFIGIN S TF+LELF + + L + +L+++ ++FPHFCLGRGLID+
Sbjct: 1647 AYVVLTCINLFIGINGSMATFVLELFSDQK-LQEVSRILKQVFLIFPHFCLGRGLIDMVR 1705
Query: 1851 SQAVTDVYARFGEEHSANPFHWDLIGKNLFAMVVEGVVYFLLTLLVQRHFFLSQWIAEPT 1910
+QA+ D + R G+ +P W+++GKNL AMV++G ++ L TLL+Q SQ + +P
Sbjct: 1706 NQAMADAFERLGDRQFQSPLRWEVVGKNLLAMVIQGPLFLLFTLLLQHR---SQLLPQPR 1762
Query: 1911 KEPIV---DEDDDVAEERQRIITGGNKTDILRLHELTKIYPGTSSPAVDRLCVGVRPGEC 1967
+ +ED+DVA ER+R++ G + D+L L LTK+Y G PAVDRLC+G+ PGEC
Sbjct: 1763 VRSLPLLGEEDEDVARERERVVQGATQGDVLVLRNLTKVYRGQRMPAVDRLCLGIPPGEC 1822
Query: 1968 FGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNISEVHQNMGYCPQFDAIDELL 2027
FGLLGVNGAGKT+TF+M+TGDT + G+A +AG S+ S H +MGYCPQ DAI ELL
Sbjct: 1823 FGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAHLSMGYCPQSDAIFELL 1882
Query: 2028 TGREHLYLYARLRGVPAEEIEKVANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAIALIG 2087
TGREHL L ARLRGVP ++ + A + LGL+ YAD AGTYSGGNKRKL+TA+AL+G
Sbjct: 1883 TGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWYADRPAGTYSGGNKRKLATALALVG 1942
Query: 2088 CPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSHSMEECEALCTRLAIMVKGA 2147
P +V LDEPTTGMDP ARR LWN +++++REGR+V+LTSHSMEECEALC+RLAIMV G
Sbjct: 1943 DPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHSMEECEALCSRLAIMVNGR 2002
Query: 2148 FRCMGTIQHLKSKFGDGYIVTMKIKSPKDDLLPDLNPVEQFFQGNFPGSVQRERHYNMLQ 2207
FRC+G+ QHLK +F G+ +T+++ + + P F FPG+ RE H L+
Sbjct: 2003 FRCLGSPQHLKGRFAAGHTLTLRVPAARS------QPAAAFVAAEFPGAELREAHGGRLR 2056
Query: 2208 FQV---SSSSLARIFQLLLSHKDSLLIEEYSVTQTTLDQVFVNFAKQQTESHD 2257
FQ+ +LAR+F L H +E++SV+QT L++VF+ F+K Q + D
Sbjct: 2057 FQLPPGGRCALARVFGELAVHGAEHGVEDFSVSQTMLEEVFLYFSKDQGKDED 2109
Score = 149 bits (375), Expect = 4e-35
Identities = 82/236 (34%), Positives = 133/236 (56%), Gaps = 13/236 (5%)
Query: 1 MGFVRQIQLLLWKNWTLRKRQKIRFVVELVWPLSLFLVLIWLRNANPLYSHHECHFPNKA 60
M F Q+ LLLWKN+ R+RQ ++ +VEL+WPL LF +L+ +R+++P HHECHFPNK
Sbjct: 1 MAFWTQLMLLLWKNFMYRRRQPVQLLVELLWPLFLFFILVAVRHSHPPLEHHECHFPNKP 60
Query: 61 MPSAGMLPWLQGIFCNVNNPCFQSPTPGESPGIVSNYNNSILARVYRDFQELLMNAPESQ 120
+PSAG +PWLQG+ CNVNN CF TPGE PG +SN+N+S+++R+ D + +L A +
Sbjct: 61 LPSAGTVPWLQGLICNVNNTCFPQLTPGEEPGRLSNFNDSLVSRLLADARTVLGGASAHR 120
Query: 121 HLGRIWTELHILSQFMDTLRTHPERIAGRGIRIRDILKDEETLTLFLIKNIGLSDSVVYL 180
L + + L T + P + + + D+ + L+ ++ ++S+
Sbjct: 121 TLAGLGKLIATLRAARSTAQPQPTKQSPLEPPMLDVAE--------LLTSLLRTESLGLA 172
Query: 181 LINSQVRPEQFAHGVPDLALKDIACSEALLERFIIFSQRRGA----KTVRYALCSL 232
L +Q DLA +++ +L+E + + RG + + ALCS+
Sbjct: 173 LGQAQEPLHSLLEAAEDLA-QELLALRSLVELRALLQRPRGTSGPLELLSEALCSV 227
>gi|45446740 ATP-binding cassette, sub-family A, member 2 isoform a
[Homo sapiens]
Length = 2436
Score = 1360 bits (3520), Expect = 0.0
Identities = 795/2002 (39%), Positives = 1144/2002 (57%), Gaps = 235/2002 (11%)
Query: 397 KILYTPDSPAARRILKNANSTFEELEHVRKLVKAWEEVGPQIWYFFDNSTQMNMIRDTLG 456
KILY P R++ AN TF + +V + W + +I F + +R
Sbjct: 459 KILYAPAGSEVDRVILKANETFAFVGNVTHYAQVWLNISAEIRSFLEQGRLQQHLR---- 514
Query: 457 NPTVKDFLNRQLGEEGITAEAILNFLYKGPRESQADDMANFDWRDIFNITDRTLRLVN-- 514
+L + + E + EA+ L + P + D NF + + + N
Sbjct: 515 ------WLQQYVAELRLHPEALNLSLDELPPALRQD---NFSLPSGMALLQQLDTIDNAA 565
Query: 515 ----QYLECLVLDKFESYNDETQLTQRALS-LLEENM-FWAGVVFPDMYPWTSSLPPHVK 568
Q++ + +D F+ + DE + L+ ++N+ +A V+F SLPPHV
Sbjct: 566 CGWIQFMSKVSVDIFKGFPDEESIVNYTLNQAYQDNVTVFASVIFQTRKD--GSLPPHVH 623
Query: 569 YKIRMDIDVVEKTNKIKDRYWDSGPRADPVEDFRYIWGGFAYLQDMVEQGITRSQVQAEA 628
YKIR + EKTN+I+ YW GP F Y GF ++QDM+E+ I + V +
Sbjct: 624 YKIRQNSSFTEKTNEIRRAYWRPGPNTGGRFYFLY---GFVWIQDMMERAIIDTFVGHDV 680
Query: 629 -PVGIYLQQMPYPCFVDDSFMIILNRCFPIFMVLAWIYSVSMTVKSIVLEKELRLKETLK 687
G Y+Q PYPC+ D F+ ++ P+ MV++W+YSV+MT++ IV EKE RLKE +K
Sbjct: 681 VEPGSYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSVAMTIQHIVAEKEHRLKEVMK 740
Query: 688 NQGVSNAVIWCTWFLDSFSIMSMSIFLLTIFIMHGRILHYSDPFILFLFLLAFSTATIML 747
G++NAV W WF+ F +S+S+ LT + +G++L +S I++LFL ++ ATIM
Sbjct: 741 TMGLNNAVHWVAWFITGFVQLSISVTALTAILKYGQVLMHSHVVIIWLFLAVYAVATIMF 800
Query: 748 CFLLSTFFSKASLAAACSGVIYFTLYLPHILCFAWQ----DRMTAELKKAVSLLSPVAFG 803
CFL+S +SKA LA+AC G+IYF Y+P++ + D++TA K SL+S AFG
Sbjct: 801 CFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHDKITAFEKCIASLMSTTAFG 860
Query: 804 FGTEYLVRFEEQGLGLQWSNIGNSPTEGDEFSFLLSMQMMLLDAAVYGLLAWYLDQVFPG 863
G++Y +E G+G+QW SP EGD+F+ LL++ M+++DA VYG+L WY++ V PG
Sbjct: 861 LGSKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVTMLMVDAVVYGILTWYIEAVHPG 920
Query: 864 DYGTPLPWYFLLQESYWLGG----------EGCSTREERALEKTEPLTEETEDPEHPEGI 913
YG P PWYF LQ+SYWLG T +E+ + E+ E G+
Sbjct: 921 MYGLPRPWYFPLQKSYWLGSGRTEAWEWSWPWARTPRLSVMEEDQACAMESRRFEETRGM 980
Query: 914 HDSFFEREHPGWVP-GVCVKNLVKIFEPCGRPAVDRLNITFYENQITAFLGHNGAGKTTT 972
E P +P VCV L K+++ + A+++L++ YENQ+ +FLGHNGAGKTTT
Sbjct: 981 E------EEPTHLPLVVCVDKLTKVYKDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTT 1034
Query: 973 LSILTGLLPPTSGTVLVGGRDIETSLDAVRQSLGMCPQHNILFHHLTVAEHMLFYAQLKG 1032
+SILTGL PPTSG+ + G DI T +D +R++LGMCPQHN+LF LTV EH+ FY++LK
Sbjct: 1035 MSILTGLFPPTSGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKS 1094
Query: 1033 KSQEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVAIAFVGDAKVVILDEPTSGV 1092
+QEE + EM+ M+ED L +KR+ Q LSGGM+RKLSVAIAFVG ++ +ILDEPT+GV
Sbjct: 1095 MAQEEIRREMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGV 1154
Query: 1093 DPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIAIIAQGRLYCSGTPLFLKNCFG 1152
DPY+RR+IWDL+LKY+ GRTI++STHHMDEADLLGDRIAII+ G+L C G+PLFLK +G
Sbjct: 1155 DPYARRAIWDLILKYKPGRTILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYG 1214
Query: 1153 TGLYLTLVRKMKNIQSQRKGSEGTCSCSSKGFSTTCPAHVDDLTPEQVLDGDVNELMDVV 1212
G LTLV++ ++ G + G +++ P + ++ ++ +
Sbjct: 1215 DGYRLTLVKR----PAEPGGPQ------EPGLASSPPGRAPLSSCSEL------QVSQFI 1258
Query: 1213 LHHVPEAKLVECIGQELIFLLPNKNFKHRAYASLFRELEETLADLGLSSFGISDTPLEEI 1272
HV LV EL ++LP++ K A+ LF+ LE +L L LSSFG+ DT LEE+
Sbjct: 1259 RKHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLERSLDALHLSSFGLMDTTLEEV 1318
Query: 1273 FLKVTEDSDSGPLFAGGAQQKRENVNPRHPCLGPREKAG------------QTPQDSNVC 1320
FLKV+E+ S ++ R++V P GP G Q+
Sbjct: 1319 FLKVSEEDQSLENSEADVKESRKDVLPGAE--GPASGEGHAGNLARCSELTQSQASLQSA 1376
Query: 1321 SPGAPAAHPEG--------------QPPPEPEC---------------PGPQLNTGTQLV 1351
S A EG P +P+ G + G L
Sbjct: 1377 SSVGSARGDEGAGYTDVYGDYRPLFDNPQDPDNVSLQEVEAEALSRVGQGSRKLDGGWLK 1436
Query: 1352 LQHVQALLVKRFQHTIRSHKDFLAQIVLPATFVFLALMLSIVIPPFGEYPALTLHPWIYG 1411
++ LLVKRF R+ K +QI+LPA FV +A+ +++ +P G+ P L L P Y
Sbjct: 1437 VRQFHGLLVKRFHCARRNSKALFSQILLPAFFVCVAMTVALSVPEIGDLPPLVLSPSQYH 1496
Query: 1412 -----------------QQYTFFSMDEPGSEQFT--------VLADVLLNKPG------- 1439
++Y + +Q V A +L P
Sbjct: 1497 NYTQPRGNFIPYANEERREYRLRLSPDASPQQLVSTFRLPSGVGATCVLKSPANGSLGPT 1556
Query: 1440 ---------------FGNRCLKEGWLPEYPCGNSTP---WKTPSVSP------------N 1469
F + CL E + P N P PS SP +
Sbjct: 1557 LNLSSGESRLLAARFFDSMCL-ESFTQGLPLSNFVPPPPSPAPSDSPASPDEDLQAWNVS 1615
Query: 1470 ITQLFQKQKWTQVNPSPSC-----RCSTREKLTMLPECPEGAGGLPPPQRTQRSTEILQD 1524
+ + WT P RC+ + T CP GG PP R +IL D
Sbjct: 1616 LPPTAGPEMWTSAPSLPRLVREPVRCTCSAQGTGF-SCPSSVGGHPPQMRVVTG-DILTD 1673
Query: 1525 LTDRNISDFLVKTYPALIRSSLKSKFWVNEQRYGGISIGGKLPVVPITGEALVGFLSDLG 1584
+T N+S++L+ T +F ++ RYG I+ G L +P +
Sbjct: 1674 ITGHNVSEYLLFT---------SDRFRLH--RYGAITFGNVLKSIPAS------------ 1710
Query: 1585 RIMNVSGGPITREASKEIPDFLKHLETEDNIKVWFNNKGWHALVSFLNVAHNAILRASLP 1644
P ++ + +V++NNKG+H++ ++LN +NAILRA+LP
Sbjct: 1711 -------------FGTRAPPMVRKIAVRRAAQVFYNNKGYHSMPTYLNSLNNAILRANLP 1757
Query: 1645 KDR-SPEEYGITVISQPLNLTKEQLSEITVLTTSVDAVVAICVIFSMSFVPASFVLYLIQ 1703
K + +P YGITV + P+N T LS + L D V+AI +I +MSFVPASFV++L+
Sbjct: 1758 KSKGNPAAYGITVTNHPMNKTSASLS-LDYLLQGTDVVIAIFIIVAMSFVPASFVVFLVA 1816
Query: 1704 ERVNKSKHLQFISGVSPTTYWVTNFLWDIMNYSVSAGLVVGIFIGFQKKAYTSPENLPAL 1763
E+ K+KHLQF+SG +P YW+ N++WD++NY V A V I F AYTSP N PA+
Sbjct: 1817 EKSTKAKHLQFVSGCNPIIYWLANYVWDMLNYLVPATCCVIILFVFDLPAYTSPTNFPAV 1876
Query: 1764 VALLLLYGWAVIPMMYPASFLFDVPSTAYVALSCANLFIGINSSAITFILELFENNRTLL 1823
++L LLYGW++ P+MYPASF F+VPS+AYV L NLFIGI ++ TF+L+LFE+++ L
Sbjct: 1877 LSLFLLYGWSITPIMYPASFWFEVPSSAYVFLIVINLFIGITATVATFLLQLFEHDKDLK 1936
Query: 1824 RFNAVLRKLLIVFPHFCLGRGLIDLALSQAVTDVYARFGE-EHSANPFHWDLIGKNLFAM 1882
N+ L+ ++FP++ LG GL+++A ++ + + YA+ G+ + +PF WD++ + L AM
Sbjct: 1937 VVNSYLKSCFLIFPNYNLGHGLMEMAYNEYINEYYAKIGQFDKMKSPFEWDIVTRGLVAM 1996
Query: 1883 VVEGVVYFLLTLLVQRHFFLSQWIAEPTKEPI----VDEDDDVAEERQRIITGGNKTDIL 1938
VEGVV FLLT++ Q +F + P + P+ V++D DVA ERQR++ G D++
Sbjct: 1997 AVEGVVGFLLTIMCQYNF-----LRRPQRMPVSTKPVEDDVDVASERQRVLRGDADNDMV 2051
Query: 1939 RLHELTKIYPGTSSP---AVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGD 1995
++ LTK+Y AVDRLC+GVRPGECFGLLGVNGAGKT+TFKMLTGD + T G+
Sbjct: 2052 KIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGE 2111
Query: 1996 ATVAGKSILTNISEVHQNMGYCPQFDAIDELLTGREHLYLYARLRGVPAEEIEKVANWSI 2055
A V G S+L + +V Q++GYCPQ DA+ + LT REHL LY RLRG+ ++ +V W++
Sbjct: 2112 AFVNGHSVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEARVVKWAL 2171
Query: 2056 KSLGLTVYADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVS 2115
+ L LT YAD AGTYSGGNKRKLSTAIALIG P + LDEPTTGMDP+ARR LWN+I+
Sbjct: 2172 EKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILD 2231
Query: 2116 IIREGRAVVLTSHSMEECEALCTRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKIKSPK 2175
+I+ GR+VVLTSHSMEECEALCTRLAIMV G RC+G+IQHLK++FGDGY++T++ KS +
Sbjct: 2232 LIKTGRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSSQ 2291
Query: 2176 DDLLPDLNPVEQFFQGNFPGSVQRERHYNMLQFQVSSS--SLARIFQLLLSHKDSLLIEE 2233
+ V +FF NFP ++ +ERH+ +Q+Q+ S SLA++F + L IE+
Sbjct: 2292 -----SVKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHISLAQVFSKMEQVSGVLGIED 2346
Query: 2234 YSVTQTTLDQVFVNFAKQQTES 2255
YSV+QTTLD VFVNFAK+Q+++
Sbjct: 2347 YSVSQTTLDNVFVNFAKKQSDN 2368
Score = 74.3 bits (181), Expect = 1e-12
Identities = 60/204 (29%), Positives = 96/204 (47%), Gaps = 23/204 (11%)
Query: 1 MGFVRQIQLLLWKNWTLRKRQKIRFVVELVWPLSLFLVLIWLRNANPLYSHHECHFPNKA 60
MGF+ Q+QLLLWKN TL++R E+ PL LF +L+ LR P S E F A
Sbjct: 1 MGFLHQLQLLLWKNVTLKRRSPWVLAFEIFIPLVLFFILLGLRQKKPTISVKEVSFYTAA 60
Query: 61 -MPSAGMLPWLQGIFCNVNNPCFQSPTPGESPGIVSNYNNSI---LARVYRDFQELLMNA 116
+ SAG+LP +Q + + F G + N+++ L R+ R +E +
Sbjct: 61 PLTSAGILPVMQSLCPDGQRDEF---------GFLQYANSTVTQLLERLDRVVEEGNLFD 111
Query: 117 PESQHLGRIWTELHILSQFMDTLR-------THPERIAGRGIRIRDILKDEETLTLFLIK 169
P LG +EL L Q ++ L +H +R + + ++ + L FL +
Sbjct: 112 PARPSLG---SELEALRQHLEALSAGPGTSGSHLDRSTVSSFSLDSVARNPQELWRFLTQ 168
Query: 170 NIGLSDSVVYLLINSQVRPEQFAH 193
N+ L +S L+ ++V P + H
Sbjct: 169 NLSLPNSTAQALLAARVDPPEVYH 192
>gi|47078218 ATP-binding cassette, sub-family A, member 2 isoform b
[Homo sapiens]
Length = 2466
Score = 1360 bits (3520), Expect = 0.0
Identities = 795/2002 (39%), Positives = 1144/2002 (57%), Gaps = 235/2002 (11%)
Query: 397 KILYTPDSPAARRILKNANSTFEELEHVRKLVKAWEEVGPQIWYFFDNSTQMNMIRDTLG 456
KILY P R++ AN TF + +V + W + +I F + +R
Sbjct: 489 KILYAPAGSEVDRVILKANETFAFVGNVTHYAQVWLNISAEIRSFLEQGRLQQHLR---- 544
Query: 457 NPTVKDFLNRQLGEEGITAEAILNFLYKGPRESQADDMANFDWRDIFNITDRTLRLVN-- 514
+L + + E + EA+ L + P + D NF + + + N
Sbjct: 545 ------WLQQYVAELRLHPEALNLSLDELPPALRQD---NFSLPSGMALLQQLDTIDNAA 595
Query: 515 ----QYLECLVLDKFESYNDETQLTQRALS-LLEENM-FWAGVVFPDMYPWTSSLPPHVK 568
Q++ + +D F+ + DE + L+ ++N+ +A V+F SLPPHV
Sbjct: 596 CGWIQFMSKVSVDIFKGFPDEESIVNYTLNQAYQDNVTVFASVIFQTRKD--GSLPPHVH 653
Query: 569 YKIRMDIDVVEKTNKIKDRYWDSGPRADPVEDFRYIWGGFAYLQDMVEQGITRSQVQAEA 628
YKIR + EKTN+I+ YW GP F Y GF ++QDM+E+ I + V +
Sbjct: 654 YKIRQNSSFTEKTNEIRRAYWRPGPNTGGRFYFLY---GFVWIQDMMERAIIDTFVGHDV 710
Query: 629 -PVGIYLQQMPYPCFVDDSFMIILNRCFPIFMVLAWIYSVSMTVKSIVLEKELRLKETLK 687
G Y+Q PYPC+ D F+ ++ P+ MV++W+YSV+MT++ IV EKE RLKE +K
Sbjct: 711 VEPGSYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSVAMTIQHIVAEKEHRLKEVMK 770
Query: 688 NQGVSNAVIWCTWFLDSFSIMSMSIFLLTIFIMHGRILHYSDPFILFLFLLAFSTATIML 747
G++NAV W WF+ F +S+S+ LT + +G++L +S I++LFL ++ ATIM
Sbjct: 771 TMGLNNAVHWVAWFITGFVQLSISVTALTAILKYGQVLMHSHVVIIWLFLAVYAVATIMF 830
Query: 748 CFLLSTFFSKASLAAACSGVIYFTLYLPHILCFAWQ----DRMTAELKKAVSLLSPVAFG 803
CFL+S +SKA LA+AC G+IYF Y+P++ + D++TA K SL+S AFG
Sbjct: 831 CFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHDKITAFEKCIASLMSTTAFG 890
Query: 804 FGTEYLVRFEEQGLGLQWSNIGNSPTEGDEFSFLLSMQMMLLDAAVYGLLAWYLDQVFPG 863
G++Y +E G+G+QW SP EGD+F+ LL++ M+++DA VYG+L WY++ V PG
Sbjct: 891 LGSKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVTMLMVDAVVYGILTWYIEAVHPG 950
Query: 864 DYGTPLPWYFLLQESYWLGG----------EGCSTREERALEKTEPLTEETEDPEHPEGI 913
YG P PWYF LQ+SYWLG T +E+ + E+ E G+
Sbjct: 951 MYGLPRPWYFPLQKSYWLGSGRTEAWEWSWPWARTPRLSVMEEDQACAMESRRFEETRGM 1010
Query: 914 HDSFFEREHPGWVP-GVCVKNLVKIFEPCGRPAVDRLNITFYENQITAFLGHNGAGKTTT 972
E P +P VCV L K+++ + A+++L++ YENQ+ +FLGHNGAGKTTT
Sbjct: 1011 E------EEPTHLPLVVCVDKLTKVYKDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTT 1064
Query: 973 LSILTGLLPPTSGTVLVGGRDIETSLDAVRQSLGMCPQHNILFHHLTVAEHMLFYAQLKG 1032
+SILTGL PPTSG+ + G DI T +D +R++LGMCPQHN+LF LTV EH+ FY++LK
Sbjct: 1065 MSILTGLFPPTSGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKS 1124
Query: 1033 KSQEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVAIAFVGDAKVVILDEPTSGV 1092
+QEE + EM+ M+ED L +KR+ Q LSGGM+RKLSVAIAFVG ++ +ILDEPT+GV
Sbjct: 1125 MAQEEIRREMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGV 1184
Query: 1093 DPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIAIIAQGRLYCSGTPLFLKNCFG 1152
DPY+RR+IWDL+LKY+ GRTI++STHHMDEADLLGDRIAII+ G+L C G+PLFLK +G
Sbjct: 1185 DPYARRAIWDLILKYKPGRTILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYG 1244
Query: 1153 TGLYLTLVRKMKNIQSQRKGSEGTCSCSSKGFSTTCPAHVDDLTPEQVLDGDVNELMDVV 1212
G LTLV++ ++ G + G +++ P + ++ ++ +
Sbjct: 1245 DGYRLTLVKR----PAEPGGPQ------EPGLASSPPGRAPLSSCSEL------QVSQFI 1288
Query: 1213 LHHVPEAKLVECIGQELIFLLPNKNFKHRAYASLFRELEETLADLGLSSFGISDTPLEEI 1272
HV LV EL ++LP++ K A+ LF+ LE +L L LSSFG+ DT LEE+
Sbjct: 1289 RKHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLERSLDALHLSSFGLMDTTLEEV 1348
Query: 1273 FLKVTEDSDSGPLFAGGAQQKRENVNPRHPCLGPREKAG------------QTPQDSNVC 1320
FLKV+E+ S ++ R++V P GP G Q+
Sbjct: 1349 FLKVSEEDQSLENSEADVKESRKDVLPGAE--GPASGEGHAGNLARCSELTQSQASLQSA 1406
Query: 1321 SPGAPAAHPEG--------------QPPPEPEC---------------PGPQLNTGTQLV 1351
S A EG P +P+ G + G L
Sbjct: 1407 SSVGSARGDEGAGYTDVYGDYRPLFDNPQDPDNVSLQEVEAEALSRVGQGSRKLDGGWLK 1466
Query: 1352 LQHVQALLVKRFQHTIRSHKDFLAQIVLPATFVFLALMLSIVIPPFGEYPALTLHPWIYG 1411
++ LLVKRF R+ K +QI+LPA FV +A+ +++ +P G+ P L L P Y
Sbjct: 1467 VRQFHGLLVKRFHCARRNSKALFSQILLPAFFVCVAMTVALSVPEIGDLPPLVLSPSQYH 1526
Query: 1412 -----------------QQYTFFSMDEPGSEQFT--------VLADVLLNKPG------- 1439
++Y + +Q V A +L P
Sbjct: 1527 NYTQPRGNFIPYANEERREYRLRLSPDASPQQLVSTFRLPSGVGATCVLKSPANGSLGPT 1586
Query: 1440 ---------------FGNRCLKEGWLPEYPCGNSTP---WKTPSVSP------------N 1469
F + CL E + P N P PS SP +
Sbjct: 1587 LNLSSGESRLLAARFFDSMCL-ESFTQGLPLSNFVPPPPSPAPSDSPASPDEDLQAWNVS 1645
Query: 1470 ITQLFQKQKWTQVNPSPSC-----RCSTREKLTMLPECPEGAGGLPPPQRTQRSTEILQD 1524
+ + WT P RC+ + T CP GG PP R +IL D
Sbjct: 1646 LPPTAGPEMWTSAPSLPRLVREPVRCTCSAQGTGF-SCPSSVGGHPPQMRVVTG-DILTD 1703
Query: 1525 LTDRNISDFLVKTYPALIRSSLKSKFWVNEQRYGGISIGGKLPVVPITGEALVGFLSDLG 1584
+T N+S++L+ T +F ++ RYG I+ G L +P +
Sbjct: 1704 ITGHNVSEYLLFT---------SDRFRLH--RYGAITFGNVLKSIPAS------------ 1740
Query: 1585 RIMNVSGGPITREASKEIPDFLKHLETEDNIKVWFNNKGWHALVSFLNVAHNAILRASLP 1644
P ++ + +V++NNKG+H++ ++LN +NAILRA+LP
Sbjct: 1741 -------------FGTRAPPMVRKIAVRRAAQVFYNNKGYHSMPTYLNSLNNAILRANLP 1787
Query: 1645 KDR-SPEEYGITVISQPLNLTKEQLSEITVLTTSVDAVVAICVIFSMSFVPASFVLYLIQ 1703
K + +P YGITV + P+N T LS + L D V+AI +I +MSFVPASFV++L+
Sbjct: 1788 KSKGNPAAYGITVTNHPMNKTSASLS-LDYLLQGTDVVIAIFIIVAMSFVPASFVVFLVA 1846
Query: 1704 ERVNKSKHLQFISGVSPTTYWVTNFLWDIMNYSVSAGLVVGIFIGFQKKAYTSPENLPAL 1763
E+ K+KHLQF+SG +P YW+ N++WD++NY V A V I F AYTSP N PA+
Sbjct: 1847 EKSTKAKHLQFVSGCNPIIYWLANYVWDMLNYLVPATCCVIILFVFDLPAYTSPTNFPAV 1906
Query: 1764 VALLLLYGWAVIPMMYPASFLFDVPSTAYVALSCANLFIGINSSAITFILELFENNRTLL 1823
++L LLYGW++ P+MYPASF F+VPS+AYV L NLFIGI ++ TF+L+LFE+++ L
Sbjct: 1907 LSLFLLYGWSITPIMYPASFWFEVPSSAYVFLIVINLFIGITATVATFLLQLFEHDKDLK 1966
Query: 1824 RFNAVLRKLLIVFPHFCLGRGLIDLALSQAVTDVYARFGE-EHSANPFHWDLIGKNLFAM 1882
N+ L+ ++FP++ LG GL+++A ++ + + YA+ G+ + +PF WD++ + L AM
Sbjct: 1967 VVNSYLKSCFLIFPNYNLGHGLMEMAYNEYINEYYAKIGQFDKMKSPFEWDIVTRGLVAM 2026
Query: 1883 VVEGVVYFLLTLLVQRHFFLSQWIAEPTKEPI----VDEDDDVAEERQRIITGGNKTDIL 1938
VEGVV FLLT++ Q +F + P + P+ V++D DVA ERQR++ G D++
Sbjct: 2027 AVEGVVGFLLTIMCQYNF-----LRRPQRMPVSTKPVEDDVDVASERQRVLRGDADNDMV 2081
Query: 1939 RLHELTKIYPGTSSP---AVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGD 1995
++ LTK+Y AVDRLC+GVRPGECFGLLGVNGAGKT+TFKMLTGD + T G+
Sbjct: 2082 KIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGE 2141
Query: 1996 ATVAGKSILTNISEVHQNMGYCPQFDAIDELLTGREHLYLYARLRGVPAEEIEKVANWSI 2055
A V G S+L + +V Q++GYCPQ DA+ + LT REHL LY RLRG+ ++ +V W++
Sbjct: 2142 AFVNGHSVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEARVVKWAL 2201
Query: 2056 KSLGLTVYADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVS 2115
+ L LT YAD AGTYSGGNKRKLSTAIALIG P + LDEPTTGMDP+ARR LWN+I+
Sbjct: 2202 EKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILD 2261
Query: 2116 IIREGRAVVLTSHSMEECEALCTRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKIKSPK 2175
+I+ GR+VVLTSHSMEECEALCTRLAIMV G RC+G+IQHLK++FGDGY++T++ KS +
Sbjct: 2262 LIKTGRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSSQ 2321
Query: 2176 DDLLPDLNPVEQFFQGNFPGSVQRERHYNMLQFQVSSS--SLARIFQLLLSHKDSLLIEE 2233
+ V +FF NFP ++ +ERH+ +Q+Q+ S SLA++F + L IE+
Sbjct: 2322 -----SVKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHISLAQVFSKMEQVSGVLGIED 2376
Query: 2234 YSVTQTTLDQVFVNFAKQQTES 2255
YSV+QTTLD VFVNFAK+Q+++
Sbjct: 2377 YSVSQTTLDNVFVNFAKKQSDN 2398
>gi|27881501 ATP-binding cassette, sub-family A, member 12 isoform b
[Homo sapiens]
Length = 2277
Score = 1119 bits (2894), Expect = 0.0
Identities = 678/1970 (34%), Positives = 1068/1970 (54%), Gaps = 170/1970 (8%)
Query: 343 NNYKAFLGIDSTRKDPI--YSYDRRTTSFCNALIQSLESNPLTKIAWRAAKPLLMGKILY 400
N+ K FL T++ Y +T FC +L + + + P + W KP+L+G+ILY
Sbjct: 434 NHTKDFLTYKLTKEQIASKYGIPINSTPFCFSLYKDIINMPAGPVIWAFLKPMLLGRILY 493
Query: 401 TPDSPAARRILKNANSTFEELEHVRKLVKAWEEVGPQIWYFFDNSTQ-MNMIRDTLGNPT 459
P +P + I++ +N T +L +R+ + W + P F Q + M+++TL NP
Sbjct: 494 APYNPVTKAIMEKSNVTLRQLAELREKSQEWMDKSPLFMNSFHLLNQAIPMLQNTLRNPF 553
Query: 460 VKDFLNRQLGEEGITAEAILNFLYKGPRESQADDMANFDWRDIFNITDRTLRLVNQYLEC 519
V+ F+ +G + + L K E + + DI + + L C
Sbjct: 554 VQVFVKFSVGLDAVE-------LLKQIDELDILRLKLENNIDIIDQLNTLSSLTVNISSC 606
Query: 520 LVLDKFESYNDETQLTQRALSLLEENMFWAGVVF--PDMYPWTSS-------LPPHVKYK 570
++ D+ ++ ++ + A L + N + V+F P W LPP +KY
Sbjct: 607 VLYDRIQAAKTIDEMEREAKRLYKSNELFGSVIFKLPSNRSWHRGYDSGNVFLPPVIKYT 666
Query: 571 IRMDIDVVEKTNKIKDRYWDSGPRADPVEDFRYIWG-GFAYLQDMVEQGITRSQVQAEAP 629
IRM + + T ++ + W GP P + I+G F YLQD +E+ I Q +
Sbjct: 667 IRMSLKTAQTTRSLRTKIWAPGPHNSPSHN--QIYGRAFIYLQDSIERAIIELQTGRNSQ 724
Query: 630 -VGIYLQQMPYPCFVDDSFMIILNRCFPIFMVLAWIYSVSMTVKSIVLEKELRLKETLKN 688
+ + +Q +PYPCF+ D+F+ ++ PI +++AW+ ++ VK +V EK+LRL E +K
Sbjct: 725 EIAVQVQAIPYPCFMKDNFLTSVSYSLPIVLMVAWVVFIAAFVKKLVYEKDLRLHEYMKM 784
Query: 689 QGVSNAVIWCTWFLDSFSIMSMSIFLLTIFIMHGRILHYSDPFILFLFLLAFSTATIMLC 748
GV++ + W ++S + ++I +L I + G IL ++ FILFL+ +S + I +
Sbjct: 785 MGVNSCSHFFAWLIESVGFLLVTIVILIIILKFGNILPKTNGFILFLYFSDYSFSVIAMS 844
Query: 749 FLLSTFFSKASLAAACSGVIYFTLYLPHILCFAWQDRMTAELKKAVSLLSPVAFGFGTEY 808
+L+S FF+ ++AA +IY + P I+ ++ ++ LK +SLLSP AF + ++Y
Sbjct: 845 YLISVFFNNTNIAALIGSLIYIIAFFPFIVLVTVENELSYVLKVFMSLLSPTAFSYASQY 904
Query: 809 LVRFEEQGLGLQWSNIGNSPTEGDEFSFLLSMQMMLLDAAVYGLLAWYLDQVFPGDYGTP 868
+ R+EEQG+GLQW N+ SP + D SF ++L D+ +Y L+AWY+ VFPG YG
Sbjct: 905 IARYEEQGIGLQWENMYTSPVQDDTTSFGWLCCLILADSFIYFLIAWYVRNVFPGTYGMA 964
Query: 869 LPWYFLLQESYWLGGEGCS---TREERALEKTEPLTEETEDPEHPEGIHDSFFEREHPGW 925
PWYF + SYW GC+ + L T + + T PE + S E E
Sbjct: 965 APWYFPILPSYWKERFGCAEVKPEKSNGLMFTNIMMQNTNPSASPEYMFSSNIEPEPKDL 1024
Query: 926 VPGVCVKNLVKIFEPCGRPAVDRLNITFYENQITAFLGHNGAGKTTTLSILTGLLPPTSG 985
GV + + KI+ + AVD LN+ FYE IT+ LG NGAGKTTT+S+LTGL ++G
Sbjct: 1025 TVGVALHGVTKIYG--SKVAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASAG 1082
Query: 986 TVLVGGRDIETSLDAVRQSLGMCPQHNILFHHLTVAEHMLFYAQLKGKSQEEAQL--EME 1043
T+ V G+DI+T L VR+++G+C QH++LF +LT EH+L Y +K + QL E++
Sbjct: 1083 TIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVK 1142
Query: 1044 AMLEDTGLHHKRNEEAQDLSGGMQRKLSVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDL 1103
L+DTGL+ R++ LSGGM+RKLS++IA +G ++VVILDEP++GVDP SRRSIWD+
Sbjct: 1143 RTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDV 1202
Query: 1104 LLKYRSGRTIIMSTHHMDEADLLGDRIAIIAQGRLYCSGTPLFLKNCFGTGLYLTLVRKM 1163
+ K ++ RTII+STHH+DEA++L DRIA + QG L C G+P +LK FG G +LTL +K
Sbjct: 1203 ISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKK- 1261
Query: 1164 KNIQSQRKGSEGTCSCSSKGFSTTCPAHVDDLTPEQVLDGDVNELMDVVLHHVPEAKLVE 1223
+S + C D + ++ H+PEA L E
Sbjct: 1262 ---KSPNLNANAVC--------------------------DTMAVTAMIQSHLPEAYLKE 1292
Query: 1224 CIGQELIFLLPNKNFK-HRAYASLFRELEETLADLGLSSFGISDTPLEEIFLKVTEDS-- 1280
IG EL+++LP + K AY SL R L+ + DL + +GISDT +EE+FL +T++S
Sbjct: 1293 DIGGELVYVLPPFSTKVSGAYLSLLRALDNGMGDLNIGCYGISDTTVEEVFLNLTKESQK 1352
Query: 1281 DSGPLFAGGAQQKRENVNPRHPCLGPREKAGQTPQDSNVCSPGAPAAHPEGQPPPEPECP 1340
+S Q+K N N TP D +V S +
Sbjct: 1353 NSAMSLEHLTQKKIGNSN---------ANGISTPDDLSVSSSNFT------DRDDKILTR 1397
Query: 1341 GPQLNTGTQLVLQHVQALLVKRFQHTIRSHKDFLAQIVLPATFVFLALMLSIVIPPFGEY 1400
G +L+ G L+L+ + A+L+KRF HT R+ K +AQ++LP FV A+ L + Y
Sbjct: 1398 GERLD-GFGLLLKKIMAILIKRFHHTRRNWKGLIAQVILPIVFVTTAMGLGTLRNSSNSY 1456
Query: 1401 PALTLHPWIYG--QQYTFFSMDEPGSEQFTVLADVLLNKPGFGNRCLKEGWLPEYPCGNS 1458
P + + P +YG +Q F++ P +E L + + PG N CL L +
Sbjct: 1457 PEIQISPSLYGTSEQTAFYANYHPSTE---ALVSAMWDFPGIDNMCLNTSDLQCLNKDSL 1513
Query: 1459 TPWKTPSVSPNITQLFQKQKWTQVNPSPSCRCSTREKLTMLPECPEGAGGLPPPQRTQRS 1518
W T + C CS + ECP+ PP R S
Sbjct: 1514 EKWNTSG--------------EPITNFGVCSCSEN-----VQECPK--FNYSPPHRRTYS 1552
Query: 1519 TEILQDLTDRNISDFLVKTYPALIRSSLKSKFWVNEQRYGGISIGGKLPVVPITGEALVG 1578
++++ +LT + + ++L+ T + ++RYGG S G +P+T +
Sbjct: 1553 SQVIYNLTGQRVENYLISTANEFV-----------QKRYGGWSFG-----LPLTKDLR-- 1594
Query: 1579 FLSDLGRIMNVSGGPITREASKEIPDFLKHLETEDNIKVWFNNKGWHALVSFLNVAHNAI 1638
+++G P R + KVW++ +G+H+L ++LN +N +
Sbjct: 1595 --------FDITGVPANRTLA----------------KVWYDPEGYHSLPAYLNSLNNFL 1630
Query: 1639 LRASLPKDRSPEEYGITVISQPLNLTKEQLSEITVLTTSVDAVVAICVIFSMSFVPASFV 1698
LR ++ K +GI + S P ++Q E +++ +D +VA+ ++ S ASFV
Sbjct: 1631 LRVNMSK-YDAARHGIIMYSHPYPGVQDQ--EQATISSLIDILVALSILMGYSVTTASFV 1687
Query: 1699 LYLIQERVNKSKHLQFISGVSPTTYWVTNFLWDIMNYSVSAGLVVGIFIGFQKKAYTSPE 1758
Y+++E K+K LQ ISG+ T YWVTNF++D++ Y V +GI F+ A+ S
Sbjct: 1688 TYVVREHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLVPVAFSIGIIAIFKLPAFYSEN 1747
Query: 1759 NLPALVALLLLYGWAVIPMMYPASFLFDVPSTAYVALSCANLFIGINS----SAITFILE 1814
NL A+ LLLL+G+A MY + LF A++ C NLF GINS S + F+ +
Sbjct: 1748 NLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFITYVCVNLFFGINSIVSLSVVYFLSK 1807
Query: 1815 LFENNRTLLRFNAVLRKLLIVFPHFCLGRGLIDLALSQAVTDVYARFGEEHSANPFHWDL 1874
N+ TL + L+++ ++FP FC G GLI+L+ Q+V D +G E+ F +
Sbjct: 1808 EKPNDPTLELISETLKRIFLIFPQFCFGYGLIELSQQQSVLDFLKAYGVEYPNETFEMNK 1867
Query: 1875 IGKNLFAMVVEGVVYFLLTLLVQR------HFFLSQWIAEPTKEPIVDEDDDVAEERQRI 1928
+G A+V +G ++F L LL+ F ++ + +E I DED+DV ER R+
Sbjct: 1868 LGAMFVALVSQGTMFFSLRLLINESLIKKLRLFFRKFNSSHVRETI-DEDEDVRAERLRV 1926
Query: 1929 ITGGNKTDILRLHELTKIYPGTSSP--AVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLT 1986
+G + D+++L+ LTK Y AV+ + +G+ GECFGLLGVNGAGKTT FKMLT
Sbjct: 1927 ESGAAEFDLVQLYCLTKTYQLIHKKIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLT 1986
Query: 1987 GDTTVTSGDATVAGKSILTNISEVHQNM-GYCPQFDAIDELLTGREHLYLYARLRGVPAE 2045
GD +SG+ + K+ + H ++ GYCPQ DA+D+L+T EHLY YAR+ G+P +
Sbjct: 1987 GDIIPSSGNILIRNKTGSLGHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEK 2046
Query: 2046 EIEKVANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQA 2105
+I++ + ++ L L + D S G KRKLSTA+ALIG P ++LLDEP++GMDP++
Sbjct: 2047 DIKETVHKLLRRLHLMPFKDRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKS 2106
Query: 2106 RRMLWNVIVSIIREGRAVVLTSHSMEECEALCTRLAIMVKGAFRCMGTIQHLKSKFGDGY 2165
+R LW +I ++ +V+LTSHSMEECEALCTRLAIMV G F+C+G++QH+KS+FG G+
Sbjct: 2107 KRHLWKIISEEVQNKCSVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGF 2166
Query: 2166 IVTMKIKSPKDDLLPDLNPVEQFFQGNFPGSVQRERHYNMLQFQ--VSSSSLARIFQLLL 2223
V + +K+ K + + +F Q +FP + +++H +ML++ V++ +A IF LL
Sbjct: 2167 TVKVHLKNNK----VTMETLTKFMQLHFPKTYLKDQHLSMLEYHVPVTAGGVANIFDLLE 2222
Query: 2224 SHKDSLLIEEYSVTQTTLDQVFVNFAKQQTESHDLPLHPRAAGASRQAQD 2273
++K +L I + V+QTTL++VF+NFAK Q + + S +QD
Sbjct: 2223 TNKTALNITNFLVSQTTLEEVFINFAKDQKSYETADTSSQGSTISVDSQD 2272
>gi|30795238 ATP-binding cassette, sub-family A, member 12 isoform a
[Homo sapiens]
Length = 2595
Score = 1119 bits (2894), Expect = 0.0
Identities = 678/1970 (34%), Positives = 1068/1970 (54%), Gaps = 170/1970 (8%)
Query: 343 NNYKAFLGIDSTRKDPI--YSYDRRTTSFCNALIQSLESNPLTKIAWRAAKPLLMGKILY 400
N+ K FL T++ Y +T FC +L + + + P + W KP+L+G+ILY
Sbjct: 752 NHTKDFLTYKLTKEQIASKYGIPINSTPFCFSLYKDIINMPAGPVIWAFLKPMLLGRILY 811
Query: 401 TPDSPAARRILKNANSTFEELEHVRKLVKAWEEVGPQIWYFFDNSTQ-MNMIRDTLGNPT 459
P +P + I++ +N T +L +R+ + W + P F Q + M+++TL NP
Sbjct: 812 APYNPVTKAIMEKSNVTLRQLAELREKSQEWMDKSPLFMNSFHLLNQAIPMLQNTLRNPF 871
Query: 460 VKDFLNRQLGEEGITAEAILNFLYKGPRESQADDMANFDWRDIFNITDRTLRLVNQYLEC 519
V+ F+ +G + + L K E + + DI + + L C
Sbjct: 872 VQVFVKFSVGLDAVE-------LLKQIDELDILRLKLENNIDIIDQLNTLSSLTVNISSC 924
Query: 520 LVLDKFESYNDETQLTQRALSLLEENMFWAGVVF--PDMYPWTSS-------LPPHVKYK 570
++ D+ ++ ++ + A L + N + V+F P W LPP +KY
Sbjct: 925 VLYDRIQAAKTIDEMEREAKRLYKSNELFGSVIFKLPSNRSWHRGYDSGNVFLPPVIKYT 984
Query: 571 IRMDIDVVEKTNKIKDRYWDSGPRADPVEDFRYIWG-GFAYLQDMVEQGITRSQVQAEAP 629
IRM + + T ++ + W GP P + I+G F YLQD +E+ I Q +
Sbjct: 985 IRMSLKTAQTTRSLRTKIWAPGPHNSPSHN--QIYGRAFIYLQDSIERAIIELQTGRNSQ 1042
Query: 630 -VGIYLQQMPYPCFVDDSFMIILNRCFPIFMVLAWIYSVSMTVKSIVLEKELRLKETLKN 688
+ + +Q +PYPCF+ D+F+ ++ PI +++AW+ ++ VK +V EK+LRL E +K
Sbjct: 1043 EIAVQVQAIPYPCFMKDNFLTSVSYSLPIVLMVAWVVFIAAFVKKLVYEKDLRLHEYMKM 1102
Query: 689 QGVSNAVIWCTWFLDSFSIMSMSIFLLTIFIMHGRILHYSDPFILFLFLLAFSTATIMLC 748
GV++ + W ++S + ++I +L I + G IL ++ FILFL+ +S + I +
Sbjct: 1103 MGVNSCSHFFAWLIESVGFLLVTIVILIIILKFGNILPKTNGFILFLYFSDYSFSVIAMS 1162
Query: 749 FLLSTFFSKASLAAACSGVIYFTLYLPHILCFAWQDRMTAELKKAVSLLSPVAFGFGTEY 808
+L+S FF+ ++AA +IY + P I+ ++ ++ LK +SLLSP AF + ++Y
Sbjct: 1163 YLISVFFNNTNIAALIGSLIYIIAFFPFIVLVTVENELSYVLKVFMSLLSPTAFSYASQY 1222
Query: 809 LVRFEEQGLGLQWSNIGNSPTEGDEFSFLLSMQMMLLDAAVYGLLAWYLDQVFPGDYGTP 868
+ R+EEQG+GLQW N+ SP + D SF ++L D+ +Y L+AWY+ VFPG YG
Sbjct: 1223 IARYEEQGIGLQWENMYTSPVQDDTTSFGWLCCLILADSFIYFLIAWYVRNVFPGTYGMA 1282
Query: 869 LPWYFLLQESYWLGGEGCS---TREERALEKTEPLTEETEDPEHPEGIHDSFFEREHPGW 925
PWYF + SYW GC+ + L T + + T PE + S E E
Sbjct: 1283 APWYFPILPSYWKERFGCAEVKPEKSNGLMFTNIMMQNTNPSASPEYMFSSNIEPEPKDL 1342
Query: 926 VPGVCVKNLVKIFEPCGRPAVDRLNITFYENQITAFLGHNGAGKTTTLSILTGLLPPTSG 985
GV + + KI+ + AVD LN+ FYE IT+ LG NGAGKTTT+S+LTGL ++G
Sbjct: 1343 TVGVALHGVTKIYG--SKVAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASAG 1400
Query: 986 TVLVGGRDIETSLDAVRQSLGMCPQHNILFHHLTVAEHMLFYAQLKGKSQEEAQL--EME 1043
T+ V G+DI+T L VR+++G+C QH++LF +LT EH+L Y +K + QL E++
Sbjct: 1401 TIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVK 1460
Query: 1044 AMLEDTGLHHKRNEEAQDLSGGMQRKLSVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDL 1103
L+DTGL+ R++ LSGGM+RKLS++IA +G ++VVILDEP++GVDP SRRSIWD+
Sbjct: 1461 RTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDV 1520
Query: 1104 LLKYRSGRTIIMSTHHMDEADLLGDRIAIIAQGRLYCSGTPLFLKNCFGTGLYLTLVRKM 1163
+ K ++ RTII+STHH+DEA++L DRIA + QG L C G+P +LK FG G +LTL +K
Sbjct: 1521 ISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKK- 1579
Query: 1164 KNIQSQRKGSEGTCSCSSKGFSTTCPAHVDDLTPEQVLDGDVNELMDVVLHHVPEAKLVE 1223
+S + C D + ++ H+PEA L E
Sbjct: 1580 ---KSPNLNANAVC--------------------------DTMAVTAMIQSHLPEAYLKE 1610
Query: 1224 CIGQELIFLLPNKNFK-HRAYASLFRELEETLADLGLSSFGISDTPLEEIFLKVTEDS-- 1280
IG EL+++LP + K AY SL R L+ + DL + +GISDT +EE+FL +T++S
Sbjct: 1611 DIGGELVYVLPPFSTKVSGAYLSLLRALDNGMGDLNIGCYGISDTTVEEVFLNLTKESQK 1670
Query: 1281 DSGPLFAGGAQQKRENVNPRHPCLGPREKAGQTPQDSNVCSPGAPAAHPEGQPPPEPECP 1340
+S Q+K N N TP D +V S +
Sbjct: 1671 NSAMSLEHLTQKKIGNSN---------ANGISTPDDLSVSSSNFT------DRDDKILTR 1715
Query: 1341 GPQLNTGTQLVLQHVQALLVKRFQHTIRSHKDFLAQIVLPATFVFLALMLSIVIPPFGEY 1400
G +L+ G L+L+ + A+L+KRF HT R+ K +AQ++LP FV A+ L + Y
Sbjct: 1716 GERLD-GFGLLLKKIMAILIKRFHHTRRNWKGLIAQVILPIVFVTTAMGLGTLRNSSNSY 1774
Query: 1401 PALTLHPWIYG--QQYTFFSMDEPGSEQFTVLADVLLNKPGFGNRCLKEGWLPEYPCGNS 1458
P + + P +YG +Q F++ P +E L + + PG N CL L +
Sbjct: 1775 PEIQISPSLYGTSEQTAFYANYHPSTE---ALVSAMWDFPGIDNMCLNTSDLQCLNKDSL 1831
Query: 1459 TPWKTPSVSPNITQLFQKQKWTQVNPSPSCRCSTREKLTMLPECPEGAGGLPPPQRTQRS 1518
W T + C CS + ECP+ PP R S
Sbjct: 1832 EKWNTSG--------------EPITNFGVCSCSEN-----VQECPK--FNYSPPHRRTYS 1870
Query: 1519 TEILQDLTDRNISDFLVKTYPALIRSSLKSKFWVNEQRYGGISIGGKLPVVPITGEALVG 1578
++++ +LT + + ++L+ T + ++RYGG S G +P+T +
Sbjct: 1871 SQVIYNLTGQRVENYLISTANEFV-----------QKRYGGWSFG-----LPLTKDLR-- 1912
Query: 1579 FLSDLGRIMNVSGGPITREASKEIPDFLKHLETEDNIKVWFNNKGWHALVSFLNVAHNAI 1638
+++G P R + KVW++ +G+H+L ++LN +N +
Sbjct: 1913 --------FDITGVPANRTLA----------------KVWYDPEGYHSLPAYLNSLNNFL 1948
Query: 1639 LRASLPKDRSPEEYGITVISQPLNLTKEQLSEITVLTTSVDAVVAICVIFSMSFVPASFV 1698
LR ++ K +GI + S P ++Q E +++ +D +VA+ ++ S ASFV
Sbjct: 1949 LRVNMSK-YDAARHGIIMYSHPYPGVQDQ--EQATISSLIDILVALSILMGYSVTTASFV 2005
Query: 1699 LYLIQERVNKSKHLQFISGVSPTTYWVTNFLWDIMNYSVSAGLVVGIFIGFQKKAYTSPE 1758
Y+++E K+K LQ ISG+ T YWVTNF++D++ Y V +GI F+ A+ S
Sbjct: 2006 TYVVREHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLVPVAFSIGIIAIFKLPAFYSEN 2065
Query: 1759 NLPALVALLLLYGWAVIPMMYPASFLFDVPSTAYVALSCANLFIGINS----SAITFILE 1814
NL A+ LLLL+G+A MY + LF A++ C NLF GINS S + F+ +
Sbjct: 2066 NLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFITYVCVNLFFGINSIVSLSVVYFLSK 2125
Query: 1815 LFENNRTLLRFNAVLRKLLIVFPHFCLGRGLIDLALSQAVTDVYARFGEEHSANPFHWDL 1874
N+ TL + L+++ ++FP FC G GLI+L+ Q+V D +G E+ F +
Sbjct: 2126 EKPNDPTLELISETLKRIFLIFPQFCFGYGLIELSQQQSVLDFLKAYGVEYPNETFEMNK 2185
Query: 1875 IGKNLFAMVVEGVVYFLLTLLVQR------HFFLSQWIAEPTKEPIVDEDDDVAEERQRI 1928
+G A+V +G ++F L LL+ F ++ + +E I DED+DV ER R+
Sbjct: 2186 LGAMFVALVSQGTMFFSLRLLINESLIKKLRLFFRKFNSSHVRETI-DEDEDVRAERLRV 2244
Query: 1929 ITGGNKTDILRLHELTKIYPGTSSP--AVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLT 1986
+G + D+++L+ LTK Y AV+ + +G+ GECFGLLGVNGAGKTT FKMLT
Sbjct: 2245 ESGAAEFDLVQLYCLTKTYQLIHKKIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLT 2304
Query: 1987 GDTTVTSGDATVAGKSILTNISEVHQNM-GYCPQFDAIDELLTGREHLYLYARLRGVPAE 2045
GD +SG+ + K+ + H ++ GYCPQ DA+D+L+T EHLY YAR+ G+P +
Sbjct: 2305 GDIIPSSGNILIRNKTGSLGHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEK 2364
Query: 2046 EIEKVANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQA 2105
+I++ + ++ L L + D S G KRKLSTA+ALIG P ++LLDEP++GMDP++
Sbjct: 2365 DIKETVHKLLRRLHLMPFKDRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKS 2424
Query: 2106 RRMLWNVIVSIIREGRAVVLTSHSMEECEALCTRLAIMVKGAFRCMGTIQHLKSKFGDGY 2165
+R LW +I ++ +V+LTSHSMEECEALCTRLAIMV G F+C+G++QH+KS+FG G+
Sbjct: 2425 KRHLWKIISEEVQNKCSVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGF 2484
Query: 2166 IVTMKIKSPKDDLLPDLNPVEQFFQGNFPGSVQRERHYNMLQFQ--VSSSSLARIFQLLL 2223
V + +K+ K + + +F Q +FP + +++H +ML++ V++ +A IF LL
Sbjct: 2485 TVKVHLKNNK----VTMETLTKFMQLHFPKTYLKDQHLSMLEYHVPVTAGGVANIFDLLE 2540
Query: 2224 SHKDSLLIEEYSVTQTTLDQVFVNFAKQQTESHDLPLHPRAAGASRQAQD 2273
++K +L I + V+QTTL++VF+NFAK Q + + S +QD
Sbjct: 2541 TNKTALNITNFLVSQTTLEEVFINFAKDQKSYETADTSSQGSTISVDSQD 2590
Score = 65.5 bits (158), Expect = 6e-10
Identities = 27/80 (33%), Positives = 48/80 (60%)
Query: 6 QIQLLLWKNWTLRKRQKIRFVVELVWPLSLFLVLIWLRNANPLYSHHECHFPNKAMPSAG 65
Q+Q+L+WKNW KRQ + +V ++WP+ +F++L R P + C+ + +PS G
Sbjct: 7 QLQILVWKNWLGVKRQPLWTLVLILWPVIIFIILAITRTKFPPTAKPTCYLAPRNLPSTG 66
Query: 66 MLPWLQGIFCNVNNPCFQSP 85
P+LQ + C+ ++ C +P
Sbjct: 67 FFPFLQTLLCDTDSKCKDTP 86
>gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13
[Homo sapiens]
Length = 5058
Score = 1036 bits (2680), Expect = 0.0
Identities = 715/2149 (33%), Positives = 1105/2149 (51%), Gaps = 207/2149 (9%)
Query: 151 IRIRDILKDEETLTLFLIKNIGLSDSVVYLLINSQVRPEQFAHGVPDLALKDIACSEALL 210
++I+D++K+ LT L +I +S+ ++ ++ + + + +AL C + +L
Sbjct: 3068 VKIKDLMKNITKLTEELRSSIQISNETIHSILEANISHSKVLFSALTVALSG-KCDQEIL 3126
Query: 211 ERFIIFSQRRGAKTVRYALCSLSQGTLQWIEDTLYANVDFFKLFRVLPTLLDSRSQGINL 270
+ F + + LCSL + + L N+D + TL+ S + G+ L
Sbjct: 3127 HLLLTFPKGEKSWIAAEELCSLPGSKVYSLIVLLSRNLDVRAF--IYKTLMPSEANGL-L 3183
Query: 271 RSWGGILSDMSPRIQ----------EFIHRPSMQDLLWVTRPLMQNGGPETFTKLMGILS 320
S I+S +S + EF+H + LL + + + G
Sbjct: 3184 NSLLDIVSSLSALLAKAQHVFEYLPEFLHTFKITALLETLDFQQVSQNVQARSSAFGSFQ 3243
Query: 321 DLLCGYPEGGGSRVLSFNWYEDNNYKAFLGIDSTRKDPIYSYDRRTTSFCNALIQSLESN 380
++ + S + N + + L D K ++ +T FC L Q +
Sbjct: 3244 FVMKMVCKDQASFLSDSNMFINLPRVKELLEDDKEK---FNIPEDSTPFCLKLYQEILQL 3300
Query: 381 PLTKIAWRAAKPLLMGKILYTPDSPAARRILKNANSTFEELEHVRKLVKAWEEVGPQIWY 440
P + W KP+L GKILYTP++P ++++ AN TF ++ ++ L + E+ ++
Sbjct: 3301 PNGALVWTFLKPILHGKILYTPNTPEINKVIQKANYTFYIVDKLKTLSETLLEMS-SLFQ 3359
Query: 441 FFDNSTQMNMIRDTLGNPTVKDFLNRQLGEEGITAEAILNFL--YKGPRESQADDMANFD 498
+ N +++ L N V++F+ QL I + + L Y G D+M N
Sbjct: 3360 RSGSGQMFNQLQEALRNKFVRNFVENQLH---IDVDKLTEKLQTYGG----LLDEMFNHA 3412
Query: 499 WRDIFNITDRTLRLVNQYLECLVLDKFESYNDETQLTQRALSLLEENMFWAGVVFPDMY- 557
F L ++ C+ L++F++ L +A LL++N F A ++F +
Sbjct: 3413 GAGRFRFLGSILVNLSS---CVALNRFQALQSVDILETKAHELLQQNSFLASIIFSNSLF 3469
Query: 558 -----PWTSSLPPHVKYKIRMDIDVVEKTNKIKDRYWDSGPRADPVEDFRYIWGGFAYLQ 612
+ LPPHV Y IR ++ +T+ +K+ W P+ P + F+Y + FA LQ
Sbjct: 3470 DKNFRSESVKLPPHVSYTIRTNVLYSVRTDVVKNPSWKFHPQNLPADGFKYNYV-FAPLQ 3528
Query: 613 DMVEQGITRSQVQAEA-PVGIYLQQMPYPCFVDDSFMIILNRCFPIFMVLAWIYSVSMTV 671
DM+E+ I Q EA Q PYPC D F+ + FP+ M+L W+ SV+ V
Sbjct: 3529 DMIERAIILVQTGQEALEPAAQTQAAPYPCHTSDLFLNNVGFFFPLIMMLTWMVSVASMV 3588
Query: 672 KSIVLEKELRLKETLKNQGVSNAVIWCTWFLDSFSIMSMSIFLLTIFIMHGRILHYSDPF 731
+ +V E+E++++E ++ GV + + WFL++ +++++S L I + I +S+ F
Sbjct: 3589 RKLVYEQEIQIEEYMRMMGVHPVIHFLAWFLENMAVLTISSATLAIVLKTSGIFAHSNTF 3648
Query: 732 ILFLFLLAFSTATIMLCFLLSTFFSKASLAAACSGVIYFTLYLPHILCFAWQDRMTAELK 791
I+FLFLL F + +ML +LLS FFS+A+ AA C+ ++Y +LP+I+ ++++ +
Sbjct: 3649 IVFLFLLDFGMSVVMLSYLLSAFFSQANTAALCTSLVYMISFLPYIVLLVLHNQLSFVNQ 3708
Query: 792 KAVSLLSPVAFGFGTEYLVRFEEQGLGLQWSNIGNSPTEGDEFSFLLSMQMMLLDAAVYG 851
+ LLS AFG G ++ E Q G+QW+N+ + +G +F M+L D+++Y
Sbjct: 3709 TFLCLLSTTAFGQGVFFITFLEGQETGIQWNNMYQALEQGG-MTFGWVCWMILFDSSLYF 3767
Query: 852 LLAWYLDQVFPGDYGTPLPWYFLLQESYWLGGEGCSTREERALEKTEPLTEETEDPEHPE 911
L WYL + PG +G PWYF SYW + + L + E D +
Sbjct: 3768 LCGWYLSNLIPGTFGLRKPWYFPFTASYWKSVGFLVEKRQYFLSSSLFFFNENFDNK--- 3824
Query: 912 GIHDSFFEREHPGWVPGVCVKNLVKIFEPCGRPAVDRLNITFYENQITAFLGHNGAGKTT 971
G E E G PGV + ++ K +E + V L++TFY +QITA LG NGAGKTT
Sbjct: 3825 GSSLQNREGELEGSAPGVTLVSVTKEYEG-HKAVVQDLSLTFYRDQITALLGTNGAGKTT 3883
Query: 972 TLSILTGLLPPTSGTVLVGGRDIETSLDAVRQSLGMCPQHNILFHHLTVAEHMLFYAQLK 1031
+S+LTGL PPTSGT+++ G++++T L VR LG+CPQ +IL +LTV EH+L +A +K
Sbjct: 3884 IISMLTGLHPPTSGTIIINGKNLQTDLSRVRMELGVCPQQDILLDNLTVREHLLLFASIK 3943
Query: 1032 GK--SQEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVAIAFVGDAKVVILDEPT 1089
+++E ++ L+D L ++++ + LSGG++RKLS+ IAF+G ++ V+LDEPT
Sbjct: 3944 APQWTKKELHQQVNQTLQDVDLTQHQHKQTRALSGGLKRKLSLGIAFMGMSRTVVLDEPT 4003
Query: 1090 SGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIAIIAQGRLYCSGTPLFLKN 1149
SGVDP SR S+WD+LLKYR GRTII +THH+DEA+ L DR+A++ GRL C G P LK
Sbjct: 4004 SGVDPCSRHSLWDILLKYREGRTIIFTTHHLDEAEALSDRVAVLQHGRLRCCGPPFCLKE 4063
Query: 1150 CFGTGLYLTLVRKMKNIQSQRKGSEGTCSCSSKGFSTTCPAHVDDLTPEQVLDGDVNELM 1209
+G GL LTL R+ +++ DL D+ +
Sbjct: 4064 AYGQGLRLTLTRQPSVLEAH------------------------DLK-------DMACVT 4092
Query: 1210 DVVLHHVPEAKLVECIGQELIFLLPNKNFKHRAYASLFRELEETLADLGLSSFGISDTPL 1269
++ ++P+A L + G EL + +P K+ LF+ L+E L L L+ +GISDT L
Sbjct: 4093 SLIKIYIPQAFLKDSSGSELTYTIP-KDTDKACLKGLFQALDENLHQLHLTGYGISDTTL 4151
Query: 1270 EEIFLKVTEDSDSGPLFAGGAQQKRENVNPRHPCLGPREKAGQTPQDSNVCSPGAPAAHP 1329
EE+FL + +DS+ A G + + +N P T S C A
Sbjct: 4152 EEVFLMLLQDSNKKSHIALGTESELQNHRP-------------TGHLSGYCGSLA----- 4193
Query: 1330 EGQPPPEPECPGPQLNTGTQLVLQHVQALLVKRFQHTIRSHKDFLAQIVLPATFVFLALM 1389
P G QL+ V A+L +R + T+R+ K LA ++LP FV LA+
Sbjct: 4194 -----------RPATVQGVQLLRAQVAAILARRLRRTLRAGKSTLADLLLPVLFVALAMG 4242
Query: 1390 LSIVIPPFGEYPALTLHPWIYGQQYTFFSMDEPGSEQFTVLADVLLNKPGFGNRCLKEGW 1449
L +V P EYP L L P Y + T+F G + L VLL K F ++
Sbjct: 4243 LFMVRPLATEYPPLRLTPGHYQRAETYFF--SSGGDNLD-LTRVLLRK--FRDQ------ 4291
Query: 1450 LPEYPCGNSTPWKTPSVSPNITQLFQKQKWTQVNPSPSCRCSTREKLTMLPECPEGAGGL 1509
+ PC + P +QK + SC R PE + G L
Sbjct: 4292 --DLPCADLNP---------------RQK------NSSC---WRTDPFSHPEFQDSCGCL 4325
Query: 1510 PPPQRTQRSTEILQDL--TDRNISDFLVKTYPALIRSSLKSKFWVNEQRYGGISIGGKLP 1567
P R+ + + L T N+S F ++ Y L+ S K R GG S G K+P
Sbjct: 4326 KCPNRSASAPYLTNHLGHTLLNLSGFNMEEY--LLAPSEK-------PRLGGWSFGLKIP 4376
Query: 1568 VVPITGEALVGFLSDLGRIMNVSGGPITREASKEIPDFLKHLETEDNIKVWFNNKGWHAL 1627
EA G N+S P KVW+N KG+H+L
Sbjct: 4377 -----SEA-------GGANGNISKPPTL-------------------AKVWYNQKGFHSL 4405
Query: 1628 VSFLNVAHNAILRASLPKDRSPEEYGITVISQPLNLTKEQLSEITVLTTSVDAVVAICVI 1687
S+LN +N IL LP +YGIT+ S P L++ +L + VA+C++
Sbjct: 4406 PSYLNHLNNLILWQHLPPTVDWRQYGITLYSHPYG--GALLNKDKILESIRQCGVALCIV 4463
Query: 1688 FSMSFVPASFVLYLIQERVNKSKHLQFISGVSPTTYWVTNFLWDIMNYSVSAGLVVGIFI 1747
S + AS ++++RV +K LQ ISG+ YW TNFL+D++ Y VS L V + +
Sbjct: 4464 LGFSILSASIGSSVVRDRVIGAKRLQHISGLGYRMYWFTNFLYDMLFYLVSVCLCVAVIV 4523
Query: 1748 GFQKKAYTSPENLPALVALLLLYGWAVIPMMYPASFLFDVPSTAYVALSCANLFIGINSS 1807
FQ A+T +NL A LL L+G+A +P MY S +F A+++ N G+ +
Sbjct: 4524 AFQLTAFTFRKNLAATALLLSLFGYATLPWMYLMSRIFSSSDVAFISYVSLNFIFGLCTM 4583
Query: 1808 AITF---ILELFENNRTLLRFNAVLRKLLIVFPHFCLGRGLIDLALSQAVTDVYARFGEE 1864
IT +L + + L VL+ + +FP FCLG+GL++L +Q D+ FG +
Sbjct: 4584 LITIMPRLLAIISKAKNLQNIYDVLKWVFTIFPQFCLGQGLVELCYNQIKYDLTHNFGID 4643
Query: 1865 HSANPFHWDLIGKNLFAMVVEGVVYFLLTLLVQRHFFLSQW-IAEPTKEPIV--DEDDDV 1921
+PF + +G + +G V LL +L+ H+ L +W T + V +D DV
Sbjct: 4644 SYVSPFEMNFLGWIFVQLASQGTVLLLLRVLL--HWDLLRWPRGHSTLQGTVKSSKDTDV 4701
Query: 1922 AEERQRIITGGNKTDILRLHELTKIYPG--TSSPAVDRLCVGVRPGECFGLLGVNGAGKT 1979
+E +R+ G DIL L+ L+K Y + AV + +G+ GECFGLLGVNGAGK+
Sbjct: 4702 EKEEKRVFEGRTNGDILVLYNLSKHYRRFFQNIIAVQDISLGIPKGECFGLLGVNGAGKS 4761
Query: 1980 TTFKMLTGDTTVTSGDA---TVAGKSI-LTNISEVHQNMGYCPQFDAIDELLTGREHLYL 2035
TTFKML G+ ++TSG A T G ++ L++ +GYCPQ DA+DELLTG EHLY
Sbjct: 4762 TTFKMLNGEVSLTSGHAIIRTPMGDAVDLSSAGTAGVLIGYCPQQDALDELLTGWEHLYY 4821
Query: 2036 YARLRGVPAEEIEKVANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAIALIGCPPLVLLD 2095
Y LRG+P + I +VA I+ L L +AD TYSGG KRKLSTA+AL+G P ++LLD
Sbjct: 4822 YCSLRGIPRQCIPEVAGDLIRRLHLEAHADKPVATYSGGTKRKLSTALALVGKPDILLLD 4881
Query: 2096 EPTTGMDPQARRMLWNVIVSIIREGRAVVLTSHSMEECEALCTRLAIMVKGAFRCMGTIQ 2155
EP++GMDP ++R LW I+ +REG A VLTSHSMEECEALCTRLAIMV G+F+C+G+ Q
Sbjct: 4882 EPSSGMDPCSKRYLWQTIMKEVREGCAAVLTSHSMEECEALCTRLAIMVNGSFKCLGSPQ 4941
Query: 2156 HLKSKFGDGYIVTMKIKSPKDDLLPDLNPVEQFFQGNFPGSVQRERHYNMLQFQVSS--S 2213
H+K++FGDGY V + + + V + FPG + +H N+L++ V
Sbjct: 4942 HIKNRFGDGYTVKVWLCKEANQHC----TVSDHLKLYFPGIQFKGQHLNLLEYHVPKRWG 4997
Query: 2214 SLARIFQLLLSHKDSLLIEEYSVTQTTLDQVFVNFAKQQTESHDLPLHP 2262
LA +F+++ ++K L I+ YS+ QTTL+QVF+NFA +Q ++ L P
Sbjct: 4998 CLADLFKVIENNKTFLNIKHYSINQTTLEQVFINFASEQQQTLQSTLDP 5046
Score = 67.4 bits (163), Expect = 2e-10
Identities = 37/135 (27%), Positives = 62/135 (45%), Gaps = 12/135 (8%)
Query: 6 QIQLLLWKNWTLRKRQKIRFVVELVWPLSLFLVLIWLRNANPLYSHHECHFPNKAMPSAG 65
Q + LLWKNW R R + F+ E WP LF++L LR P C+ + +PS G
Sbjct: 7 QFKALLWKNWLCRLRNPVLFLAEFFWPCILFVILTVLRFQEPPRYRDICYLQPRDLPSCG 66
Query: 66 MLPWLQGIFCNVNNPCFQSPTPG-----------ESPGIVSNYNNSILARVYRDF-QELL 113
++P++Q + CN + C G ++ NN + +D +E+
Sbjct: 67 VIPFVQSLLCNTGSRCRNFSYEGSMEHHFRLSRFQTAADPKKVNNLAFLKEIQDLAEEIH 126
Query: 114 MNAPESQHLGRIWTE 128
++++L R+W E
Sbjct: 127 GMMDKAKNLKRLWVE 141
>gi|116734710 ATP-binding cassette, sub-family A member 3 [Homo
sapiens]
Length = 1704
Score = 527 bits (1358), Expect = e-149
Identities = 324/840 (38%), Positives = 470/840 (55%), Gaps = 84/840 (10%)
Query: 603 YIWGGFAYLQDMVEQGITRSQVQAEAP-----VGIYLQQMPYPCFVDDSFMIILNRCFPI 657
YI GF +Q V++ I A + + +++ PYP F+ D F++ + P+
Sbjct: 206 YIREGFLAVQHAVDRAIMEYHADAATRQLFQRLTVTIKRFPYPPFIADPFLVAIQYQLPL 265
Query: 658 FMVLAWIYSVSMTVKSIVLEKELRLKETLKNQGVSNAVIWCTWFLDSFSIMSMSIFLLTI 717
++L++ Y+ +++V EKE RLKE ++ G+S+ + W WFL F + ++ +T+
Sbjct: 266 LLLLSFTYTALTIARAVVQEKERRLKEYMRMMGLSSWLHWSAWFLLFFLFLLIAASFMTL 325
Query: 718 FIM-----HGRILHYSDPFILFLFLLAFSTATIMLCFLLSTFFSKASLAAACSGVIYFTL 772
+ +L SDP ++ FLL F+ +TI F++STFFSKA++AAA G +YF
Sbjct: 326 LFCVKVKPNVAVLSRSDPSLVLAFLLCFAISTISFSFMVSTFFSKANMAAAFGGFLYFFT 385
Query: 773 YLPHILCFAWQDRMTAELKKAVSLLSPVAFGFGTEYLVRFEEQGLGLQWSNIGNSPTEGD 832
Y+P+ + MT K LLS VA G + + +FE +G+G+QW ++ + D
Sbjct: 386 YIPYFFVAPRYNWMTLSQKLCSCLLSNVAMAMGAQLIGKFEAKGMGIQWRDLLSPVNVDD 445
Query: 833 EFSFLLSMQMMLLDAAVYGLLAWYLDQVFPGDYGTPLPWYFLLQESYWLGGEGCSTREER 892
+F F + M+LLD+ +YGL+ WY++ VFPG +G P PWYF + SYW G + R
Sbjct: 446 DFCFGQVLGMLLLDSVLYGLVTWYMEAVFPGQFGVPQPWYFFIMPSYWCG-------KPR 498
Query: 893 ALEKTEPLTEETEDPEHPEGIHDSFFEREHPGWVPGVCVKNLVKIFEPCG--RPAVDRLN 950
A+ E EE DPE + + + +FE E V G+ +K+L K+F R AV LN
Sbjct: 499 AVAGKE---EEDSDPE--KALRNEYFEAEPEDLVAGIKIKHLSKVFRVGNKDRAAVRDLN 553
Query: 951 ITFYENQITAFLGHNGAGKTTTLSILTGLLPPTSGTVLVGGRDIETSLDAVRQSLGMCPQ 1010
+ YE QIT LGHNGAGKTTTLS+LTGL PPTSG + G +I + +R+SLG+CPQ
Sbjct: 554 LNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMVQIRKSLGLCPQ 613
Query: 1011 HNILFHHLTVAEHMLFYAQLKGKSQEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKL 1070
H+ILF +LTVAEH+ FYAQLKG S+++ E++ ML GL K N ++ LSGGM+RKL
Sbjct: 614 HDILFDNLTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWNSRSRFLSGGMRRKL 673
Query: 1071 SVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRI 1130
S+ IA + +KV+ILDEPTSG+D SRR+IWDLL + +S RTI+++TH MDEADLLGDRI
Sbjct: 674 SIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLTTHFMDEADLLGDRI 733
Query: 1131 AIIAQGRLYCSGTPLFLKNCFGTGLYLTLVRKMKNIQSQRKGSEGTCSCSSKGFSTTCPA 1190
AI+A+G L C G+ LFLK +G G ++TLV+ E C+
Sbjct: 734 AIMAKGELQCCGSSLFLKQKYGAGYHMTLVK------------EPHCN------------ 769
Query: 1191 HVDDLTPEQVLDGDVNELMDVVLHHVPEAKLVECIGQELIFLLPNKNFKHRAYASLFREL 1250
PE D+++L V HHVP A L G EL F+LP ++ HR + LF +L
Sbjct: 770 ------PE-----DISQL---VHHHVPNATLESSAGAELSFILPRES-THR-FEGLFAKL 813
Query: 1251 EETLADLGLSSFGISDTPLEEIFLKVTEDSDSG----PLFAGGAQQKRENVNPRHPCLGP 1306
E+ +LG++SFG S T +EE+FL+V + DS + Q + E
Sbjct: 814 EKKQKELGIASFGASITTMEEVFLRVGKLVDSSMDIQAIQLPALQYQHE----------- 862
Query: 1307 REKAGQTPQDSNVCSPGAPAAHPEGQPPPEPECPGPQLNTGTQLVLQHVQALLVKRFQHT 1366
+A DSN+C GA E E +LNTG L Q A+ +K+ ++
Sbjct: 863 -RRASDWAVDSNLC--GAMDPSDGIGALIEEERTAVKLNTGLALHCQQFWAMFLKKAAYS 919
Query: 1367 IRSHKDFLAQIVLPATFVFLALMLSIVIPPFGEYPALTLHPWIYGQQYTFFSMDEPGSEQ 1426
R K AQ+++P T V LAL+ + P L L YG+ FS+ PG+ Q
Sbjct: 920 WREWKMVAAQVLVPLTCVTLALLAINYSSELFDDPMLRLTLGEYGRTVVPFSV--PGTSQ 977
Score = 434 bits (1115), Expect = e-121
Identities = 247/668 (36%), Positives = 385/668 (57%), Gaps = 39/668 (5%)
Query: 1615 IKVWFNNKGWHALVSFLNVAHNAILRASLPKDRSPEEYGITVISQPLNLTKEQLSEITVL 1674
+ FNN+ +H+ + L V N + + S L K+Q +E
Sbjct: 1038 VNALFNNQAYHSPATALAVVDNLLFKLLCGPHASIVVSNFPQPRSALQAAKDQFNE---- 1093
Query: 1675 TTSVDAVVAICVIFSMSFVPASFVLYLIQERVNKSKHLQFISGVSPTTYWVTNFLWDIMN 1734
+A+ ++F+M+F+ ++F + + ER ++KH+QF+SGV ++W++ LWD+++
Sbjct: 1094 -GRKGFDIALNLLFAMAFLASTFSILAVSERAVQAKHVQFVSGVHVASFWLSALLWDLIS 1152
Query: 1735 YSVSAGLVVGIFIGFQKKAYTSPENLPALVALLLLYGWAVIPMMYPASFLFDVPSTAYVA 1794
+ + + L++ +F F +A+T ++ + LLLLYGWA+IP+MY +F F +TAY
Sbjct: 1153 FLIPSLLLLVVFKAFDVRAFTRDGHMADTLLLLLLYGWAIIPLMYLMNFFFLGAATAYTR 1212
Query: 1795 LSCANLFIGINSSAITFILELFENNRTLLRFNAVLRKLLIVFPHFCLGRGLIDL------ 1848
L+ N+ GI + + I+ + L + L + +V P+ CLG +
Sbjct: 1213 LTIFNILSGIATFLMVTIMRIPAVK--LEELSKTLDHVFLVLPNHCLGMAVSSFYENYET 1270
Query: 1849 ----ALSQAVTDVYARFGEEHSANPFHWDL--IGKNLFAMVVEGVVYFLLTLLVQRHFFL 1902
S+ ++ ++ N + W +G+ + +M G Y +L L++ +
Sbjct: 1271 RRYCTSSEVAAHYCKKYNIQYQENFYAWSAPGVGRFVASMAASGCAYLILLFLIETNLLQ 1330
Query: 1903 S-----------QWIAEP-TKEPIVDEDDDVAEERQRIITGGNKTDI---LRLHELTKIY 1947
+ + E T+ P++ ED DVA+ER RI+ + + L + EL+K+Y
Sbjct: 1331 RLRGILCALRRRRTLTELYTRMPVLPEDQDVADERTRILAPSPDSLLHTPLIIKELSKVY 1390
Query: 1948 PG-TSSPAVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTN 2006
AVDRL + V+ GECFGLLG NGAGKTTTFKMLTG+ ++TSGDA V G I ++
Sbjct: 1391 EQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRISSD 1450
Query: 2007 ISEVHQNMGYCPQFDAIDELLTGREHLYLYARLRGVPAEEIEKVANWSIKSLGLTVYADC 2066
+ +V Q +GYCPQFDA+ + +TGRE L +YARLRG+P I +++ L L +A+
Sbjct: 1451 VGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTLRGLLLEPHANK 1510
Query: 2067 LAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLT 2126
L TYSGGNKRKLST IALIG P ++ LDEP+TGMDP ARR+LW+ + G+A+++T
Sbjct: 1511 LVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESGKAIIIT 1570
Query: 2127 SHSMEECEALCTRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKIKSPKDDLLPDLNPVE 2186
SHSMEECEALCTRLAIMV+G F+C+G+ QHLKSKFG GY + K++S + L +
Sbjct: 1571 SHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSLRAKVQS--EGQQEALEEFK 1628
Query: 2187 QFFQGNFPGSVQRERHYNMLQFQVSSSSL--ARIFQLLLSHKDSLLIEEYSVTQTTLDQV 2244
F FPGSV + H M+ + + L A++F +L K+ +++YSV+Q +L+QV
Sbjct: 1629 AFVDLTFPGSVLEDEHQGMVHYHLPGRDLSWAKVFGILEKAKEKYGVDDYSVSQISLEQV 1688
Query: 2245 FVNFAKQQ 2252
F++FA Q
Sbjct: 1689 FLSFAHLQ 1696
Score = 179 bits (453), Expect = 4e-44
Identities = 118/346 (34%), Positives = 181/346 (52%), Gaps = 40/346 (11%)
Query: 931 VKNLVKIFEP-CGRPAVDRLNITFYENQITAFLGHNGAGKTTTLSILTGLLPPTSGTVLV 989
+K L K++E AVDRL++ + + LG NGAGKTTT +LTG TSG V
Sbjct: 1383 IKELSKVYEQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFV 1442
Query: 990 GGRDIETSLDAVRQSLGMCPQHNILFHHLTVAEHMLFYAQLKGKSQEEAQLEMEAMLEDT 1049
GG I + + VRQ +G CPQ + L H+T E ++ YA+L+G + +E L
Sbjct: 1443 GGHRISSDVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTLRGL 1502
Query: 1050 GLHHKRNEEAQDLSGGMQRKLSVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKYR- 1108
L N+ + SGG +RKLS IA +G+ V+ LDEP++G+DP +RR +WD + + R
Sbjct: 1503 LLEPHANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARE 1562
Query: 1109 SGRTIIMSTHHMDEADLLGDRIAIIAQGRLYCSGTPLFLKNCFGTGLYLTLVRKMKNIQS 1168
SG+ II+++H M+E + L R+AI+ QG+ C G+P LK+ FG+G L R +
Sbjct: 1563 SGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSL---RAKVQSEG 1619
Query: 1169 QRKGSEGTCSCSSKGFSTTCPAHVDDLTPEQVLDGDVNELMDVVLHHVPEAKLVECIGQE 1228
Q++ E A VD P VL+ +E +V +H+P G++
Sbjct: 1620 QQEALE------------EFKAFVDLTFPGSVLE---DEHQGMVHYHLP--------GRD 1656
Query: 1229 LIFLLPNKNFKHRAYASLFRELEETLADLGLSSFGISDTPLEEIFL 1274
L ++A +F LE+ G+ + +S LE++FL
Sbjct: 1657 L------------SWAKVFGILEKAKEKYGVDDYSVSQISLEQVFL 1690
Score = 175 bits (443), Expect = 5e-43
Identities = 164/612 (26%), Positives = 282/612 (46%), Gaps = 64/612 (10%)
Query: 1684 ICVIFSMSFVPASFVLYLIQERVNKSKHLQFISGVSPTTYWVTNFLWDIMNYSVSAGLVV 1743
+ ++ S ++ + ++QE+ + K + G+S +W FL + ++A +
Sbjct: 265 LLLLLSFTYTALTIARAVVQEKERRLKEYMRMMGLSSWLHWSAWFLLFFLFLLIAASFMT 324
Query: 1744 GIFIGFQKK--AYTSPENLPALVALLLLYGWAVIPMMYPASFLFDVPSTAYVALSCANLF 1801
+F K A S + ++A LL + + I SF F V ST + + A F
Sbjct: 325 LLFCVKVKPNVAVLSRSDPSLVLAFLLCFAISTI------SFSFMV-STFFSKANMAAAF 377
Query: 1802 IGINSSAITFILELFENNR-TLLRFNAVLRKLLIVFPHFCLGRGLIDLALSQAVTDVYAR 1860
G T+I F R + + L L+ +G LI ++ + +
Sbjct: 378 GGF-LYFFTYIPYFFVAPRYNWMTLSQKLCSCLLSNVAMAMGAQLIGKFEAKGMGIQWRD 436
Query: 1861 FGEEHSANPFHWD---LIGKNLFAMVVEGVVYFLLTLLVQR------------HFFL--S 1903
+P + D G+ L ++++ V+Y L+T ++ +FF+ S
Sbjct: 437 L-----LSPVNVDDDFCFGQVLGMLLLDSVLYGLVTWYMEAVFPGQFGVPQPWYFFIMPS 491
Query: 1904 QWIAEPTKEPIVDEDDDVAEERQR----------IITGGNKTDILRLHELTKIYP--GTS 1951
W +P +E+D E+ R ++ G +++ L+K++
Sbjct: 492 YWCGKPRAVAGKEEEDSDPEKALRNEYFEAEPEDLVAG------IKIKHLSKVFRVGNKD 545
Query: 1952 SPAVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNISEVH 2011
AV L + + G+ LLG NGAGKTTT MLTG TSG A ++G I ++ ++
Sbjct: 546 RAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMVQIR 605
Query: 2012 QNMGYCPQFDAIDELLTGREHLYLYARLRGVPAEEIEKVANWSIKSLGLTVYADCLAGTY 2071
+++G CPQ D + + LT EHLY YA+L+G+ ++ + + +GL + +
Sbjct: 606 KSLGLCPQHDILFDNLTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWNSRSRFL 665
Query: 2072 SGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSHSME 2131
SGG +RKLS IALI +++LDEPT+GMD +RR +W+ ++ + R +VLT+H M+
Sbjct: 666 SGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWD-LLQRQKSDRTIVLTTHFMD 724
Query: 2132 ECEALCTRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKIKSPKDDLLPDLNP--VEQFF 2189
E + L R+AIM KG +C G+ LK K+G GY +T+ +K P NP + Q
Sbjct: 725 EADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTL-VKE------PHCNPEDISQLV 777
Query: 2190 QGNFPGSVQRERHYNMLQFQVSSSSLAR---IFQLLLSHKDSLLIEEYSVTQTTLDQVFV 2246
+ P + L F + S R +F L + L I + + TT+++VF+
Sbjct: 778 HHHVPNATLESSAGAELSFILPRESTHRFEGLFAKLEKKQKELGIASFGASITTMEEVFL 837
Query: 2247 NFAKQQTESHDL 2258
K S D+
Sbjct: 838 RVGKLVDSSMDI 849
Score = 48.1 bits (113), Expect = 1e-04
Identities = 23/43 (53%), Positives = 31/43 (72%)
Query: 1 MGFVRQIQLLLWKNWTLRKRQKIRFVVELVWPLSLFLVLIWLR 43
M +RQ+ LLLWKN+TL+KR+ + V+EL PL +LIWLR
Sbjct: 1 MAVLRQLALLLWKNYTLQKRKVLVTVLELFLPLLFSGILIWLR 43
>gi|27262624 ATP-binding cassette, sub-family A , member 5 [Homo
sapiens]
Length = 1642
Score = 273 bits (699), Expect = 1e-72
Identities = 214/797 (26%), Positives = 377/797 (47%), Gaps = 104/797 (13%)
Query: 502 IFNITDRTLRLVN-QYLECLVLDKFESYNDETQLTQRALSLLEENMFWAGVVFPDMYPWT 560
+ NIT ++ V+ +L +++ E Y +E ++ +LS + GVVF D
Sbjct: 84 VTNITSSIMQKVSTDHLPDVIIT--EEYTNEKEMLTSSLSKPSN---FVGVVFKDS---- 134
Query: 561 SSLPPHVKYKIRMDIDVVEKTNKIKDRYWDSGPRADPVEDFRYIWG-GFAYLQDMVEQGI 619
+ Y++R D++ + Y DS + W GF LQ ++ I
Sbjct: 135 ------MSYELRFFPDMIP----VSSIYMDSRAGCSKSCEAAQYWSSGFTVLQASIDAAI 184
Query: 620 TRSQVQAEAPVGIYLQQMPYPCFVDDSFMIILNRCFP-----IFMVLAWIYSVSMTVKSI 674
+Q + V ++ + + ++ FP I++V+A+ I
Sbjct: 185 ----IQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVILIYLVIAFSPFGYFLAIHI 240
Query: 675 VLEKELRLKETLKNQGVSNAVIWCTWFLDSFSIMSMSIFLLTIFIMHGRILHYSDPFILF 734
V EKE ++KE LK G+ + W +W L S++ + L+ + + S ++F
Sbjct: 241 VAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMAVIATASLLFPQSSSIVIF 300
Query: 735 LFLLAFSTATIMLCFLLSTFFSKASLAAACSGVIYFTLYLPHILCFAWQDRMTAELKKAV 794
L + +++ +L+ F K+ G++ F + + + + K V
Sbjct: 301 LLFFLYGLSSVFFALMLTPLFKKSKHV----GIVEFFVTVAFGFIGLMIILIESFPKSLV 356
Query: 795 SLLSPVA---FGFGTEYLVRFEEQGLGLQWSNIGNSPTEGDEFSFLLSMQMMLLDAAVYG 851
L SP F G ++ E+ G +SN+ P + ++++ M+ L++ Y
Sbjct: 357 WLFSPFCHCTFVIGIAQVMHLEDFNEGASFSNLTAGP-----YPLIITIIMLTLNSIFYV 411
Query: 852 LLAWYLDQVFPGDYGTPLPWYFLLQESYWLGGEGCSTREERALEKTEP--LTEETEDPEH 909
LLA YLDQV PG++G + L+ SYW ++ +R E+ + E
Sbjct: 412 LLAVYLDQVIPGEFGLRRSSLYFLKPSYW-------SKSKRNYEELSEGNVNGNISFSEI 464
Query: 910 PEGIHDSFFEREHPGWVPGVCVKNLVKIFEPCGR--PAVDRLNITFYENQITAFLGHNGA 967
E + F +E + + + K + G A+ L+ YE QITA LGH+G
Sbjct: 465 IEPVSSEFVGKE------AIRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGT 518
Query: 968 GKTTTLSILTGLLPPTSGTVLVGGR---DIETSLDAVRQSLGMCPQHNILFHHLTVAEHM 1024
GK+T ++IL GL PP+ G + G +I+ +A R+ +G+CPQ +I F LTV E++
Sbjct: 519 GKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEA-RKMIGICPQLDIHFDVLTVEENL 577
Query: 1025 LFYAQLKGKSQEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVAIAFVGDAKVVI 1084
A +KG E++ +L D + ++ +A+ LSGG +RKLS+ IA +G+ K+++
Sbjct: 578 SILASIKGIPANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILL 637
Query: 1085 LDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIAIIAQGRLYCSGTP 1144
LDEPT+G+DP SR +W+LL ++ R + STH MDEAD+L DR A+I+QG L C G+
Sbjct: 638 LDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSS 697
Query: 1145 LFLKNCFGTGLYLTLVRKMKNIQSQRKGSEGTCSCSSKGFSTTCPAHVDDLTPEQVLDGD 1204
+FLK+ +G G L++ ++D +
Sbjct: 698 MFLKSKWGIGYRLSM-------------------------------YIDKYCATE----- 721
Query: 1205 VNELMDVVLHHVPEAKLVECIGQELIFLLPNKNFKHRAYASLFRELEETLADLGLSSFGI 1264
L +V H+P A L++ Q+L++ LP K+ ++ LF L ++ ++LG+ S+G+
Sbjct: 722 --SLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMD--KFSGLFSAL-DSHSNLGVISYGV 776
Query: 1265 SDTPLEEIFLKVTEDSD 1281
S T LE++FLK+ +++
Sbjct: 777 SMTTLEDVFLKLEVEAE 793
Score = 215 bits (548), Expect = 3e-55
Identities = 176/592 (29%), Positives = 291/592 (49%), Gaps = 82/592 (13%)
Query: 1715 ISGVSPTTYWVTNFLWDIMNYSVSAGLVVGIFIGFQKKAYTSPENLPALVALLLLYGWAV 1774
+SG+ P+ YW+ + DI + + L++G + F Y A+V L+ Y +V
Sbjct: 1057 LSGLLPSAYWIGQAVVDIPLFFIILILMLGSLLAFHYGLYFYTVKFLAVVFCLIGYVPSV 1116
Query: 1775 IPMMYPASFLFD-VPST--------AYVALSCANLFIGINSSAITFILELFENNRTLLRF 1825
I Y ASF F + +T + AL+C I + ITF + T+L +
Sbjct: 1117 ILFTYIASFTFKKILNTKEFWSFIYSVAALAC------IAITEITFFMGY--TIATILHY 1168
Query: 1826 NAVLRKLLIVFPHFCLGRGLIDLALSQAVTDVYARFGEEHSANPFHWDLIGKNLFAMVVE 1885
+ ++ ++P I ++ +V + NP WD + + + ++
Sbjct: 1169 AFCI--IIPIYPLLGCLISFIKISWKNVRKNV-------DTYNP--WDRLSVAVISPYLQ 1217
Query: 1886 GVVY-FLLTLLVQRH---------FFLS-------QWIAEPTKEPIVDEDDDVAEERQRI 1928
V++ FLL +++ FF + + + EP DED+DV ER ++
Sbjct: 1218 CVLWIFLLQYYEKKYGGRSIRKDPFFRNLSTKSKNRKLPEPPDNE--DEDEDVKAERLKV 1275
Query: 1929 --ITG-------------------GNKTDILRLHELTKIYPGTSSPAVDRLCVGVRPGEC 1967
+ G +K D L ++ K+ A + V+ GE
Sbjct: 1276 KELMGCQCCEEKPSIMVSNLHKEYDDKKDFLLSRKVKKV-------ATKYISFCVKKGEI 1328
Query: 1968 FGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNISEVHQN-MGYCPQFDAIDEL 2026
GLLG NGAGK+T +L GD TSG + S T+ + MGYCPQ + +
Sbjct: 1329 LGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDSLKCMGYCPQINPLWPD 1388
Query: 2027 LTGREHLYLYARLRGVPAEEIEKVANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAIALI 2086
T +EH +Y ++G+ A ++++V + +L L + G KRKL A++++
Sbjct: 1389 TTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKTVKKLPAGIKRKLCFALSML 1448
Query: 2087 GCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREG-RAVVLTSHSMEECEALCTRLAIMVK 2145
G P + LLDEP+TGMDP+A++ +W I + + RA +LT+H MEE EA+C R+AIMV
Sbjct: 1449 GNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVCDRVAIMVS 1508
Query: 2146 GAFRCMGTIQHLKSKFGDGYIVTMKIKSPKDDLLPDLNPVEQFFQGNFPGSVQRERHYNM 2205
G RC+GT+QHLKSKFG GY + +K+K ++L +++ +++ Q FP + ++E ++
Sbjct: 1509 GQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENL--EVDRLQREIQYIFPNASRQESFSSI 1566
Query: 2206 LQFQVSS---SSLARIFQLLLSHKDSLLIEEYSVTQTTLDQVFVNFAKQQTE 2254
L +++ SL++ F L K + IEEYS +Q TL+QVFV K+Q E
Sbjct: 1567 LAYKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQVFVELTKEQEE 1618
Score = 156 bits (395), Expect = 2e-37
Identities = 148/608 (24%), Positives = 275/608 (45%), Gaps = 63/608 (10%)
Query: 1671 ITVLTTSVDAVVAICVIFSMSFVPASFVLYLIQERVNKSKHLQFISGVSPTTYWVTNFLW 1730
+ + T V+ I ++ + S ++++ E+ K K I G+ T +W++ W
Sbjct: 210 VVEIDTFPRGVILIYLVIAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLS---W 266
Query: 1731 DIMNYSVSAGLVVGIFIGFQKKAYTSPENLPALVALLL-LYGWAVIPMMYPASFLFDVPS 1789
++ Y+ L+ + + P++ ++ LL LYG + + + LF
Sbjct: 267 -VLLYTSLIFLMSLLMAVIATASLLFPQSSSIVIFLLFFLYGLSSVFFALMLTPLFK--K 323
Query: 1790 TAYVALSCANLFIGINSSAITFILELFENNRTLLRFNAVLRKLLIVFPHFCLGRGLIDLA 1849
+ +V + F+ + I ++ L E+ + L+ +F FC +I +A
Sbjct: 324 SKHVGI--VEFFVTVAFGFIGLMIILIES---------FPKSLVWLFSPFCHCTFVIGIA 372
Query: 1850 LSQAVTDVYARFGEEHS-----ANPFHWDLIGKNLFAMVVEGVVYFLLTLLVQRH----- 1899
+ D F E S A P+ + + + + + Y LL + + +
Sbjct: 373 QVMHLED----FNEGASFSNLTAGPYPLII---TIIMLTLNSIFYVLLAVYLDQVIPGEF 425
Query: 1900 -------FFL--SQWIA-----EPTKEPIVDEDDDVAEERQRIITGGNKTDILRLHELTK 1945
+FL S W E E V+ + +E + + + + +R+ + K
Sbjct: 426 GLRRSSLYFLKPSYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSEFVGKEAIRISGIQK 485
Query: 1946 IY--PGTSSPAVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSI 2003
Y G + A+ L + G+ LLG +G GK+T +L G + G A++ G +
Sbjct: 486 TYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRV 545
Query: 2004 --LTNISEVHQNMGYCPQFDAIDELLTGREHLYLYARLRGVPAEEIEKVANWSIKSLGLT 2061
+ + E + +G CPQ D ++LT E+L + A ++G+PA I + + L +
Sbjct: 546 SEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQ 605
Query: 2062 VYADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGR 2121
D A SGG KRKLS IA++G P ++LLDEPT GMDP +R ++WN ++ + R
Sbjct: 606 TIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWN-LLKYRKANR 664
Query: 2122 AVVLTSHSMEECEALCTRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKIKSPKDDLLPD 2181
V ++H M+E + L R A++ +G +C+G+ LKSK+G GY ++M I D
Sbjct: 665 VTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYI-----DKYCA 719
Query: 2182 LNPVEQFFQGNFPGSVQRERHYNMLQFQVSSSSLAR---IFQLLLSHKDSLLIEEYSVTQ 2238
+ + + PG+ +++ L + + + + +F L SH +L + Y V+
Sbjct: 720 TESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSH-SNLGVISYGVSM 778
Query: 2239 TTLDQVFV 2246
TTL+ VF+
Sbjct: 779 TTLEDVFL 786
Score = 145 bits (365), Expect = 6e-34
Identities = 100/368 (27%), Positives = 180/368 (48%), Gaps = 51/368 (13%)
Query: 927 PGVCVKNLVKIFEP---------CGRPAVDRLNITFYENQITAFLGHNGAGKTTTLSILT 977
P + V NL K ++ + A ++ + +I LG NGAGK+T ++IL
Sbjct: 1288 PSIMVSNLHKEYDDKKDFLLSRKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILV 1347
Query: 978 GLLPPTSGTVLVGGRDIETSLDAVR-QSLGMCPQHNILFHHLTVAEHMLFYAQLKGKSQE 1036
G + PTSG V +G ETS D + +G CPQ N L+ T+ EH Y +KG S
Sbjct: 1348 GDIEPTSGQVFLGDYSSETSEDDDSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSAS 1407
Query: 1037 EAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVAIAFVGDAKVVILDEPTSGVDPYS 1096
+ + + + L + + L G++RKL A++ +G+ ++ +LDEP++G+DP +
Sbjct: 1408 DMKEVISRITHALDLKEHLQKTVKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKA 1467
Query: 1097 RRSIWDLL---LKYRSGRTIIMSTHHMDEADLLGDRIAIIAQGRLYCSGTPLFLKNCFGT 1153
++ +W + K R R I++TH+M+EA+ + DR+AI+ G+L C GT LK+ FG
Sbjct: 1468 KQHMWRAIRTAFKNRK-RAAILTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGK 1526
Query: 1154 GLYLTLVRKMKNIQSQRKGSEGTCSCSSKGFSTTCPAHVDDLTPEQVLDGDVNELMDVVL 1213
G +L + K+K+ +++L +V+ L +
Sbjct: 1527 GYFLEI--KLKD-------------------------WIENL--------EVDRLQREIQ 1551
Query: 1214 HHVPEAKLVECIGQELIFLLPNKNFKHRAYASLFRELEETLADLGLSSFGISDTPLEEIF 1273
+ P A E L + +P ++ ++ + F +LEE + + S LE++F
Sbjct: 1552 YIFPNASRQESFSSILAYKIPKEDV--QSLSQSFFKLEEAKHAFAIEEYSFSQATLEQVF 1609
Query: 1274 LKVTEDSD 1281
+++T++ +
Sbjct: 1610 VELTKEQE 1617
>gi|27262626 ATP-binding cassette, sub-family A , member 5 [Homo
sapiens]
Length = 1642
Score = 273 bits (699), Expect = 1e-72
Identities = 214/797 (26%), Positives = 377/797 (47%), Gaps = 104/797 (13%)
Query: 502 IFNITDRTLRLVN-QYLECLVLDKFESYNDETQLTQRALSLLEENMFWAGVVFPDMYPWT 560
+ NIT ++ V+ +L +++ E Y +E ++ +LS + GVVF D
Sbjct: 84 VTNITSSIMQKVSTDHLPDVIIT--EEYTNEKEMLTSSLSKPSN---FVGVVFKDS---- 134
Query: 561 SSLPPHVKYKIRMDIDVVEKTNKIKDRYWDSGPRADPVEDFRYIWG-GFAYLQDMVEQGI 619
+ Y++R D++ + Y DS + W GF LQ ++ I
Sbjct: 135 ------MSYELRFFPDMIP----VSSIYMDSRAGCSKSCEAAQYWSSGFTVLQASIDAAI 184
Query: 620 TRSQVQAEAPVGIYLQQMPYPCFVDDSFMIILNRCFP-----IFMVLAWIYSVSMTVKSI 674
+Q + V ++ + + ++ FP I++V+A+ I
Sbjct: 185 ----IQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVILIYLVIAFSPFGYFLAIHI 240
Query: 675 VLEKELRLKETLKNQGVSNAVIWCTWFLDSFSIMSMSIFLLTIFIMHGRILHYSDPFILF 734
V EKE ++KE LK G+ + W +W L S++ + L+ + + S ++F
Sbjct: 241 VAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMAVIATASLLFPQSSSIVIF 300
Query: 735 LFLLAFSTATIMLCFLLSTFFSKASLAAACSGVIYFTLYLPHILCFAWQDRMTAELKKAV 794
L + +++ +L+ F K+ G++ F + + + + K V
Sbjct: 301 LLFFLYGLSSVFFALMLTPLFKKSKHV----GIVEFFVTVAFGFIGLMIILIESFPKSLV 356
Query: 795 SLLSPVA---FGFGTEYLVRFEEQGLGLQWSNIGNSPTEGDEFSFLLSMQMMLLDAAVYG 851
L SP F G ++ E+ G +SN+ P + ++++ M+ L++ Y
Sbjct: 357 WLFSPFCHCTFVIGIAQVMHLEDFNEGASFSNLTAGP-----YPLIITIIMLTLNSIFYV 411
Query: 852 LLAWYLDQVFPGDYGTPLPWYFLLQESYWLGGEGCSTREERALEKTEP--LTEETEDPEH 909
LLA YLDQV PG++G + L+ SYW ++ +R E+ + E
Sbjct: 412 LLAVYLDQVIPGEFGLRRSSLYFLKPSYW-------SKSKRNYEELSEGNVNGNISFSEI 464
Query: 910 PEGIHDSFFEREHPGWVPGVCVKNLVKIFEPCGR--PAVDRLNITFYENQITAFLGHNGA 967
E + F +E + + + K + G A+ L+ YE QITA LGH+G
Sbjct: 465 IEPVSSEFVGKE------AIRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGT 518
Query: 968 GKTTTLSILTGLLPPTSGTVLVGGR---DIETSLDAVRQSLGMCPQHNILFHHLTVAEHM 1024
GK+T ++IL GL PP+ G + G +I+ +A R+ +G+CPQ +I F LTV E++
Sbjct: 519 GKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEA-RKMIGICPQLDIHFDVLTVEENL 577
Query: 1025 LFYAQLKGKSQEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVAIAFVGDAKVVI 1084
A +KG E++ +L D + ++ +A+ LSGG +RKLS+ IA +G+ K+++
Sbjct: 578 SILASIKGIPANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILL 637
Query: 1085 LDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIAIIAQGRLYCSGTP 1144
LDEPT+G+DP SR +W+LL ++ R + STH MDEAD+L DR A+I+QG L C G+
Sbjct: 638 LDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSS 697
Query: 1145 LFLKNCFGTGLYLTLVRKMKNIQSQRKGSEGTCSCSSKGFSTTCPAHVDDLTPEQVLDGD 1204
+FLK+ +G G L++ ++D +
Sbjct: 698 MFLKSKWGIGYRLSM-------------------------------YIDKYCATE----- 721
Query: 1205 VNELMDVVLHHVPEAKLVECIGQELIFLLPNKNFKHRAYASLFRELEETLADLGLSSFGI 1264
L +V H+P A L++ Q+L++ LP K+ ++ LF L ++ ++LG+ S+G+
Sbjct: 722 --SLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMD--KFSGLFSAL-DSHSNLGVISYGV 776
Query: 1265 SDTPLEEIFLKVTEDSD 1281
S T LE++FLK+ +++
Sbjct: 777 SMTTLEDVFLKLEVEAE 793
Score = 215 bits (548), Expect = 3e-55
Identities = 176/592 (29%), Positives = 291/592 (49%), Gaps = 82/592 (13%)
Query: 1715 ISGVSPTTYWVTNFLWDIMNYSVSAGLVVGIFIGFQKKAYTSPENLPALVALLLLYGWAV 1774
+SG+ P+ YW+ + DI + + L++G + F Y A+V L+ Y +V
Sbjct: 1057 LSGLLPSAYWIGQAVVDIPLFFIILILMLGSLLAFHYGLYFYTVKFLAVVFCLIGYVPSV 1116
Query: 1775 IPMMYPASFLFD-VPST--------AYVALSCANLFIGINSSAITFILELFENNRTLLRF 1825
I Y ASF F + +T + AL+C I + ITF + T+L +
Sbjct: 1117 ILFTYIASFTFKKILNTKEFWSFIYSVAALAC------IAITEITFFMGY--TIATILHY 1168
Query: 1826 NAVLRKLLIVFPHFCLGRGLIDLALSQAVTDVYARFGEEHSANPFHWDLIGKNLFAMVVE 1885
+ ++ ++P I ++ +V + NP WD + + + ++
Sbjct: 1169 AFCI--IIPIYPLLGCLISFIKISWKNVRKNV-------DTYNP--WDRLSVAVISPYLQ 1217
Query: 1886 GVVY-FLLTLLVQRH---------FFLS-------QWIAEPTKEPIVDEDDDVAEERQRI 1928
V++ FLL +++ FF + + + EP DED+DV ER ++
Sbjct: 1218 CVLWIFLLQYYEKKYGGRSIRKDPFFRNLSTKSKNRKLPEPPDNE--DEDEDVKAERLKV 1275
Query: 1929 --ITG-------------------GNKTDILRLHELTKIYPGTSSPAVDRLCVGVRPGEC 1967
+ G +K D L ++ K+ A + V+ GE
Sbjct: 1276 KELMGCQCCEEKPSIMVSNLHKEYDDKKDFLLSRKVKKV-------ATKYISFCVKKGEI 1328
Query: 1968 FGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNISEVHQN-MGYCPQFDAIDEL 2026
GLLG NGAGK+T +L GD TSG + S T+ + MGYCPQ + +
Sbjct: 1329 LGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDSLKCMGYCPQINPLWPD 1388
Query: 2027 LTGREHLYLYARLRGVPAEEIEKVANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAIALI 2086
T +EH +Y ++G+ A ++++V + +L L + G KRKL A++++
Sbjct: 1389 TTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKTVKKLPAGIKRKLCFALSML 1448
Query: 2087 GCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREG-RAVVLTSHSMEECEALCTRLAIMVK 2145
G P + LLDEP+TGMDP+A++ +W I + + RA +LT+H MEE EA+C R+AIMV
Sbjct: 1449 GNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVCDRVAIMVS 1508
Query: 2146 GAFRCMGTIQHLKSKFGDGYIVTMKIKSPKDDLLPDLNPVEQFFQGNFPGSVQRERHYNM 2205
G RC+GT+QHLKSKFG GY + +K+K ++L +++ +++ Q FP + ++E ++
Sbjct: 1509 GQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENL--EVDRLQREIQYIFPNASRQESFSSI 1566
Query: 2206 LQFQVSS---SSLARIFQLLLSHKDSLLIEEYSVTQTTLDQVFVNFAKQQTE 2254
L +++ SL++ F L K + IEEYS +Q TL+QVFV K+Q E
Sbjct: 1567 LAYKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQVFVELTKEQEE 1618
Score = 156 bits (395), Expect = 2e-37
Identities = 148/608 (24%), Positives = 275/608 (45%), Gaps = 63/608 (10%)
Query: 1671 ITVLTTSVDAVVAICVIFSMSFVPASFVLYLIQERVNKSKHLQFISGVSPTTYWVTNFLW 1730
+ + T V+ I ++ + S ++++ E+ K K I G+ T +W++ W
Sbjct: 210 VVEIDTFPRGVILIYLVIAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLS---W 266
Query: 1731 DIMNYSVSAGLVVGIFIGFQKKAYTSPENLPALVALLL-LYGWAVIPMMYPASFLFDVPS 1789
++ Y+ L+ + + P++ ++ LL LYG + + + LF
Sbjct: 267 -VLLYTSLIFLMSLLMAVIATASLLFPQSSSIVIFLLFFLYGLSSVFFALMLTPLFK--K 323
Query: 1790 TAYVALSCANLFIGINSSAITFILELFENNRTLLRFNAVLRKLLIVFPHFCLGRGLIDLA 1849
+ +V + F+ + I ++ L E+ + L+ +F FC +I +A
Sbjct: 324 SKHVGI--VEFFVTVAFGFIGLMIILIES---------FPKSLVWLFSPFCHCTFVIGIA 372
Query: 1850 LSQAVTDVYARFGEEHS-----ANPFHWDLIGKNLFAMVVEGVVYFLLTLLVQRH----- 1899
+ D F E S A P+ + + + + + Y LL + + +
Sbjct: 373 QVMHLED----FNEGASFSNLTAGPYPLII---TIIMLTLNSIFYVLLAVYLDQVIPGEF 425
Query: 1900 -------FFL--SQWIA-----EPTKEPIVDEDDDVAEERQRIITGGNKTDILRLHELTK 1945
+FL S W E E V+ + +E + + + + +R+ + K
Sbjct: 426 GLRRSSLYFLKPSYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSEFVGKEAIRISGIQK 485
Query: 1946 IY--PGTSSPAVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSI 2003
Y G + A+ L + G+ LLG +G GK+T +L G + G A++ G +
Sbjct: 486 TYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRV 545
Query: 2004 --LTNISEVHQNMGYCPQFDAIDELLTGREHLYLYARLRGVPAEEIEKVANWSIKSLGLT 2061
+ + E + +G CPQ D ++LT E+L + A ++G+PA I + + L +
Sbjct: 546 SEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQ 605
Query: 2062 VYADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGR 2121
D A SGG KRKLS IA++G P ++LLDEPT GMDP +R ++WN ++ + R
Sbjct: 606 TIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWN-LLKYRKANR 664
Query: 2122 AVVLTSHSMEECEALCTRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKIKSPKDDLLPD 2181
V ++H M+E + L R A++ +G +C+G+ LKSK+G GY ++M I D
Sbjct: 665 VTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYI-----DKYCA 719
Query: 2182 LNPVEQFFQGNFPGSVQRERHYNMLQFQVSSSSLAR---IFQLLLSHKDSLLIEEYSVTQ 2238
+ + + PG+ +++ L + + + + +F L SH +L + Y V+
Sbjct: 720 TESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSH-SNLGVISYGVSM 778
Query: 2239 TTLDQVFV 2246
TTL+ VF+
Sbjct: 779 TTLEDVFL 786
Score = 145 bits (365), Expect = 6e-34
Identities = 100/368 (27%), Positives = 180/368 (48%), Gaps = 51/368 (13%)
Query: 927 PGVCVKNLVKIFEP---------CGRPAVDRLNITFYENQITAFLGHNGAGKTTTLSILT 977
P + V NL K ++ + A ++ + +I LG NGAGK+T ++IL
Sbjct: 1288 PSIMVSNLHKEYDDKKDFLLSRKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILV 1347
Query: 978 GLLPPTSGTVLVGGRDIETSLDAVR-QSLGMCPQHNILFHHLTVAEHMLFYAQLKGKSQE 1036
G + PTSG V +G ETS D + +G CPQ N L+ T+ EH Y +KG S
Sbjct: 1348 GDIEPTSGQVFLGDYSSETSEDDDSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSAS 1407
Query: 1037 EAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVAIAFVGDAKVVILDEPTSGVDPYS 1096
+ + + + L + + L G++RKL A++ +G+ ++ +LDEP++G+DP +
Sbjct: 1408 DMKEVISRITHALDLKEHLQKTVKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKA 1467
Query: 1097 RRSIWDLL---LKYRSGRTIIMSTHHMDEADLLGDRIAIIAQGRLYCSGTPLFLKNCFGT 1153
++ +W + K R R I++TH+M+EA+ + DR+AI+ G+L C GT LK+ FG
Sbjct: 1468 KQHMWRAIRTAFKNRK-RAAILTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGK 1526
Query: 1154 GLYLTLVRKMKNIQSQRKGSEGTCSCSSKGFSTTCPAHVDDLTPEQVLDGDVNELMDVVL 1213
G +L + K+K+ +++L +V+ L +
Sbjct: 1527 GYFLEI--KLKD-------------------------WIENL--------EVDRLQREIQ 1551
Query: 1214 HHVPEAKLVECIGQELIFLLPNKNFKHRAYASLFRELEETLADLGLSSFGISDTPLEEIF 1273
+ P A E L + +P ++ ++ + F +LEE + + S LE++F
Sbjct: 1552 YIFPNASRQESFSSILAYKIPKEDV--QSLSQSFFKLEEAKHAFAIEEYSFSQATLEQVF 1609
Query: 1274 LKVTEDSD 1281
+++T++ +
Sbjct: 1610 VELTKEQE 1617
>gi|27436953 ATP-binding cassette, sub-family A, member 6 [Homo
sapiens]
Length = 1617
Score = 267 bits (682), Expect = 1e-70
Identities = 183/642 (28%), Positives = 330/642 (51%), Gaps = 76/642 (11%)
Query: 649 IILNRCFPIFMVLAW---IYSVSMTVKSIVLEKELRLKETLKNQGVSNAVIWCTWFLDSF 705
++ N F +F +L + +Y +S+ V ++ + K +K G+ ++ W +W L
Sbjct: 217 LLHNEMFILFFLLHFSPLVYFISLNVT----KERKKSKNLMKMMGLQDSAFWLSWGLIYA 272
Query: 706 SIMSMSIFLLTIFIMHGRILHYSDPFILFLFLLAFSTATIMLCFLLSTFFSKASLAAACS 765
+ + +TI I +I+ + ++F+ + + + L FL+S KA L
Sbjct: 273 GFIFIISIFVTIIITFTQIIVMTGFMVIFILFFLYGLSLVALVFLMSVLLKKAVLTNLV- 331
Query: 766 GVIYFTLYLPHILCFAWQDRMTAELKKAVSLLSPVAFGFGTEYLVRFEEQGLGLQWSNIG 825
V TL+ + + +++ + L+ +++ SP AF G +++ + G+ + +
Sbjct: 332 -VFLLTLFWGCLGFTVFYEQLPSSLEWILNICSPFAFTTGMIQIIKLDYNLNGVIFPD-- 388
Query: 826 NSPTEGDEFSFLLSMQMMLLDAAVYGLLAWYLDQVFP-GDYGTPLPWYFLLQESYWLGGE 884
GD ++ + + M+LLD +Y LLA Y D++ P GD P +FL S +
Sbjct: 389 ---PSGDSYTMIATFSMLLLDGLIYLLLALYFDKILPYGDERHYSPLFFLNSSSCF---- 441
Query: 885 GCSTREERALEKTEPLTEETEDPEHPEGIHDSFFEREHPGWV--PGVCVKNLVKIFE-PC 941
+ +R K + E+ D EHP D +FE P + + ++N+ K ++
Sbjct: 442 ----QHQRTNAK---VIEKEIDAEHPS---DDYFEPVAPEFQGKEAIRIRNVKKEYKGKS 491
Query: 942 GR-PAVDRLNITFYENQITAFLGHNGAGKTTTLSILTGLLPPTSGTVLVGGRDIET--SL 998
G+ A+ L YE QITA LGH+GAGK++ L+IL GL PT G+V + +++ L
Sbjct: 492 GKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGSVTIYNKNLSEMQDL 551
Query: 999 DAVRQSLGMCPQHNILFHHLTVAEHMLFYAQLKGKSQEEAQLEMEAMLEDTGLHHKRNEE 1058
+ +R+ G+CPQ N+ F LTV E++ +A++KG +E + E++ +L + + + ++
Sbjct: 552 EEIRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVEQEVQRILLELDMQNIQDNL 611
Query: 1059 AQDLSGGMQRKLSVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTH 1118
A+ LS G +RKL+ I +GD ++++LDEPT+G+DP+SR +W LL + R+ I+ ST
Sbjct: 612 AKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLLRERRADHVILFSTQ 671
Query: 1119 HMDEADLLGDRIAIIAQGRLYCSGTPLFLKNCFGTGLYLTLVRKMKNIQSQRKGSEGTCS 1178
MDEAD+L DR I++ GRL C+G+ +FLK +G G +L+L R
Sbjct: 672 SMDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHLSLHRN---------------- 715
Query: 1179 CSSKGFSTTCPAHVDDLTPEQVLDGDVNELMDVVLHHVPEAKLVECIGQELIFLLPNKNF 1238
+ PEQ+ + HH+P+AKL ++L++ LP +
Sbjct: 716 --------------EICNPEQI--------TSFITHHIPDAKLKTENKEKLVYTLPLE-- 751
Query: 1239 KHRAYASLFRELEETLADLGLSSFGISDTPLEEIFLKVTEDS 1280
+ + LF +L++ +D G++ + IS + L E+F+K+ S
Sbjct: 752 RTNTFPDLFSDLDK-CSDQGVTGYDISMSTLNEVFMKLEGQS 792
Score = 196 bits (498), Expect = 2e-49
Identities = 121/364 (33%), Positives = 200/364 (54%), Gaps = 29/364 (7%)
Query: 1907 AEPTKEPIVDEDDDVAEERQRIITGG-----NKTDILRLHELTKIYPGTSSP-------- 1953
A+P E +DED+D+ ER R T ++ ++ L K Y G
Sbjct: 1241 AKPNPEEPIDEDEDIQTERIRTATALTTSILDEKPVIIASCLHKEYAGQKKSCFSKRKKK 1300
Query: 1954 -AVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNISEVHQ 2012
A + V+ GE GLLG NGAGK+++ +M++G T T+G+ + G S V
Sbjct: 1301 IAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKG------CSSVLG 1354
Query: 2013 NMGYCPQFDAIDELLTGREHLYLYARLRGVPAEEIEKVANWSIKSLGLTVYADCLAGTYS 2072
++GYCPQ + + +LT REHL +YA ++G+ + + + L + +
Sbjct: 1355 HLGYCPQENVLWPMLTLREHLEVYAAVKGLRKADARLAIARLVSAFKLHEQLNVPVQKLT 1414
Query: 2073 GGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREG-RAVVLTSHSME 2131
G RKL ++L+G P++LLDEP+TG+DP ++ +W I ++++ R V+LT+H++
Sbjct: 1415 AGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLLTTHNLA 1474
Query: 2132 ECEALCTRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKIKSPKDDLLPDLNPVEQFFQG 2191
E EALC R+AIMV G RC+G+IQHLK+K G YI+ +K+K L V
Sbjct: 1475 EAEALCDRVAIMVSGRLRCIGSIQHLKNKLGKDYILELKVKETSQVTL-----VHTEILK 1529
Query: 2192 NFPGSVQRERHYNMLQFQVSSSS---LARIFQLLLSHKDSLLIEEYSVTQTTLDQVFVNF 2248
FP + +ER+ ++L +++ + L++ F L + K + +EEYS++Q TL++VF+
Sbjct: 1530 LFPQAAGQERYSSLLTYKLPVADVYPLSQTFHKLEAVKHNFNLEEYSLSQCTLEKVFLEL 1589
Query: 2249 AKQQ 2252
+K+Q
Sbjct: 1590 SKEQ 1593
Score = 157 bits (398), Expect = 9e-38
Identities = 147/641 (22%), Positives = 296/641 (46%), Gaps = 77/641 (12%)
Query: 1656 VISQPLNLTKEQLSEITVLTTSVDAVVAICVIFSMSFVPASFVLYL-IQERVNKSKHLQF 1714
V+ + +++T + + +T ++ + F + F P + + L + + KSK+L
Sbjct: 195 VMEELMSVTAITMKTLPFITKNLLHNEMFILFFLLHFSPLVYFISLNVTKERKKSKNLMK 254
Query: 1715 ISGVSPTTYWVTNFLWDIMNYSVSAGLV--VGIFIGFQKKAYTSPENLPALVALLLLYGW 1772
+ G+ + +W++ W + + AG + + IF+ + ++++ G+
Sbjct: 255 MMGLQDSAFWLS---WGL----IYAGFIFIISIFVTI----------IITFTQIIVMTGF 297
Query: 1773 AVIPMMYPASFLFDVPSTAYVALSCANLFIGINSSAITFILELFENNRTLLRFN----AV 1828
VI +++ FL+ + A V L L + ++ + F+L LF F +
Sbjct: 298 MVIFILF---FLYGLSLVALVFLMSVLLKKAVLTNLVVFLLTLFWGCLGFTVFYEQLPSS 354
Query: 1829 LRKLLIVFPHFCLGRGLIDLALSQAVTDVYARFGEEHSANPFHWDLIGKNLFAMVVEGVV 1888
L +L + F G+I + + ++ + S + + + ++++G++
Sbjct: 355 LEWILNICSPFAFTTGMIQII--KLDYNLNGVIFPDPSGDSY---TMIATFSMLLLDGLI 409
Query: 1889 YFLLTLLV--------QRH----FFLSQ---WIAEPTKEPIVDEDDDVAEER----QRII 1929
Y LL L +RH FFL+ + + T +++++ D + +
Sbjct: 410 YLLLALYFDKILPYGDERHYSPLFFLNSSSCFQHQRTNAKVIEKEIDAEHPSDDYFEPVA 469
Query: 1930 TGGNKTDILRLHELTKIYPGTSSP--AVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTG 1987
+ +R+ + K Y G S A+ L + G+ +LG +GAGK++ +L G
Sbjct: 470 PEFQGKEAIRIRNVKKEYKGKSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNG 529
Query: 1988 DTTVTSGDATVAGKSI--LTNISEVHQNMGYCPQFDAIDELLTGREHLYLYARLRGVPAE 2045
+ T G T+ K++ + ++ E+ + G CPQF+ ++LT +E+L L+A+++G+ +
Sbjct: 530 LSVPTEGSVTIYNKNLSEMQDLEEIRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHLK 589
Query: 2046 EIEKVANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQA 2105
E+E+ + L + D LA S G KRKL+ I ++G P ++LLDEPTTG+DP +
Sbjct: 590 EVEQEVQRILLELDMQNIQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFS 649
Query: 2106 RRMLWNVIVSIIREGRA---VVLTSHSMEECEALCTRLAIMVKGAFRCMGTIQHLKSKFG 2162
R +W S++RE RA ++ ++ SM+E + L R IM G +C G+ LK ++G
Sbjct: 650 RDQVW----SLLRERRADHVILFSTQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRWG 705
Query: 2163 DGYIVTM---KIKSPKDDLLPDLNPVEQFFQGNFPGSVQRERHYNMLQFQVSSSSLARIF 2219
GY +++ +I +P+ + F + P + + + L + + F
Sbjct: 706 LGYHLSLHRNEICNPEQ--------ITSFITHHIPDAKLKTENKEKLVYTLPLER-TNTF 756
Query: 2220 QLLLSHKDSLL---IEEYSVTQTTLDQVFVNFAKQQTESHD 2257
L S D + Y ++ +TL++VF+ Q T D
Sbjct: 757 PDLFSDLDKCSDQGVTGYDISMSTLNEVFMKLEGQSTIEQD 797
Score = 145 bits (365), Expect = 6e-34
Identities = 98/344 (28%), Positives = 170/344 (49%), Gaps = 62/344 (18%)
Query: 950 NITF--YENQITAFLGHNGAGKTTTLSILTGLLPPTSGTVLVGGRDIETSLDAVRQSLGM 1007
NI+F E +I LG NGAGK++++ +++G+ PT+G V + G +V LG
Sbjct: 1305 NISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKG------CSSVLGHLGY 1358
Query: 1008 CPQHNILFHHLTVAEHMLFYAQLKGKSQEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQ 1067
CPQ N+L+ LT+ EH+ YA +KG + +A+L + ++ LH + N Q L+ G+
Sbjct: 1359 CPQENVLWPMLTLREHLEVYAAVKGLRKADARLAIARLVSAFKLHEQLNVPVQKLTAGIT 1418
Query: 1068 RKLSVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLL--LKYRSGRTIIMSTHHMDEADL 1125
RKL ++ +G++ V++LDEP++G+DP ++ +W + + + R ++++TH++ EA+
Sbjct: 1419 RKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLLTTHNLAEAEA 1478
Query: 1126 LGDRIAIIAQGRLYCSGTPLFLKNCFGTGLYLTLVRKMKNIQSQRKGSEGTCSCSSKGFS 1185
L DR+AI+ GRL C G+ LKN G
Sbjct: 1479 LCDRVAIMVSGRLRCIGSIQHLKNKLG--------------------------------- 1505
Query: 1186 TTCPAHVDDLTPEQVLDGDVNELMDVVLHHVPEAKLV-ECIGQE-----LIFLLPNKNFK 1239
+ +L+ V E V L H KL + GQE L + LP +
Sbjct: 1506 -----------KDYILELKVKETSQVTLVHTEILKLFPQAAGQERYSSLLTYKLPVADV- 1553
Query: 1240 HRAYASLFRELEETLADLGLSSFGISDTPLEEIFLKVTEDSDSG 1283
+ F +LE + L + +S LE++FL+++++ + G
Sbjct: 1554 -YPLSQTFHKLEAVKHNFNLEEYSLSQCTLEKVFLELSKEQEVG 1596
>gi|27477115 ATP-binding cassette, sub-family A, member 9 [Homo
sapiens]
Length = 1624
Score = 259 bits (662), Expect = 2e-68
Identities = 192/673 (28%), Positives = 328/673 (48%), Gaps = 84/673 (12%)
Query: 625 QAEAPVGIYLQQMPYPCF--VDDSFMIILNRCFPIFMVLAWIYSVSMTVKSIVLEKELRL 682
Q + G++++ +P+ V F I F I +IY VS+ V ++ +
Sbjct: 201 QLMSVTGVHMKILPFVAQGGVATDFFIF----FCIISFSTFIYYVSVNVT----QERQYI 252
Query: 683 KETLKNQGVSNAVIWCTWFLDSFSIMSMSIFLLTIFIMHGRILHYSDPFILFLFLLAFST 742
+ G+ + W +W L + + L+ + + +I+ + ++F L +
Sbjct: 253 TSLMTMMGLRESAFWLSWGLMYAGFILIMATLMALIVKSAQIVVLTGFVMVFTLFLLYGL 312
Query: 743 ATIMLCFLLSTFFSKASLAAACSGVIYFTLYLPHILCF-AWQDRMTAELKKAVSLLSPVA 801
+ I L FL+S K L V++ + IL F A R+ A L+ + LLSP A
Sbjct: 313 SLITLAFLMSVLIKKPFLTGL---VVFLLIVFWGILGFPALYTRLPAFLEWTLCLLSPFA 369
Query: 802 FGFGTEYLVRFEEQGLGLQWSNIGNSPTEGDEFSFLL--SMQMMLLDAAVYGLLAWYLDQ 859
F G L+ L + N+ + + +L+ ++ M++ D +Y +L Y D+
Sbjct: 370 FTVGMAQLIH-------LDYDVNSNAHLDSSQNPYLIIATLFMLVFDTLLYLVLTLYFDK 422
Query: 860 VFPGDYGTPLPWYFLLQESYWLGGEGCSTREERALEKTEPLTEETEDPEHPEGIHDSFFE 919
+ P +YG F L+ +W + ++P + +P PE F
Sbjct: 423 ILPAEYGHRCSPLFFLKSCFWFQHGRANHVVLENETDSDPTPNDCFEPVSPE-----FCG 477
Query: 920 REHPGWVPGVCVKNLVKIFE-PCGR-PAVDRLNITFYENQITAFLGHNGAGKTTTLSILT 977
+E + +KNL K + C R A+ + YE QITA LGH+GAGKTT L+IL+
Sbjct: 478 KE------AIRIKNLKKEYAGKCERVEALKGVVFDIYEGQITALLGHSGAGKTTLLNILS 531
Query: 978 GLLPPTSGTVLVGGRDIETSLDA--VRQSLGMCPQHNILFHHLTVAEHMLFYAQLKGKSQ 1035
GL PTSG+V V + D + + G CPQ N+ F LTV E++ +A++KG
Sbjct: 532 GLSVPTSGSVTVYNHTLSRMADIENISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILP 591
Query: 1036 EEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVAIAFVGDAKVVILDEPTSGVDPY 1095
E + E++ ++++ + + ++ AQ+LSGG RKL+ IA +GD +V++LDEPT+G+DP
Sbjct: 592 HEVEKEVQRVVQELEMENIQDILAQNLSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPL 651
Query: 1096 SRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIAIIAQGRLYCSGTPLFLKNCFGTGL 1155
SR IW+LL + +S R I+ ST +DEAD+L DR I+ G+L C+G+ LFLK +G G
Sbjct: 652 SRHRIWNLLKEGKSDRVILFSTQFIDEADILADRKVFISNGKLKCAGSSLFLKKKWGIGY 711
Query: 1156 YLTLVRKMKNIQSQRKGSEGTCSCSSKGFSTTCPAHVDDLTPEQVLDGDVNELMDVVLHH 1215
+L+L H+++ D + +V H
Sbjct: 712 HLSL-------------------------------HLNERC-------DPESITSLVKQH 733
Query: 1216 VPEAKLVECIGQELIFLLPNKNFKHRAYASLFRELEETLADLGLSSFGISDTPLEEIFLK 1275
+ +AKL ++L+++LP + + + L+R+L+ ++ G+ +G+S T L E+FLK
Sbjct: 734 ISDAKLTAQSEEKLVYILPLE--RTNKFPELYRDLDR-CSNQGIEDYGVSITTLNEVFLK 790
Query: 1276 V-----TEDSDSG 1283
+ ++SD G
Sbjct: 791 LEGKSTIDESDIG 803
Score = 209 bits (533), Expect = 2e-53
Identities = 178/611 (29%), Positives = 277/611 (45%), Gaps = 96/611 (15%)
Query: 1695 ASFVLYLIQERVN---KSKHLQF-ISGVSPTTYWVTNFLWDIMNYSVSAGLVVGIFIGFQ 1750
ASF Y+ + K H Q ISG+ P+ YW L D+ Y + I + Q
Sbjct: 1034 ASFTPYIAMSSIGDYKKKAHSQLRISGLYPSAYWFGQALVDVSLYFL-------ILLLMQ 1086
Query: 1751 KKAYT-SPENLPALVALLLLYGWAVIPMMYPASFLFDVPSTAYVALSCANLFIGINSSAI 1809
Y SPE + ++ LL+ + + Y +S +F YV I
Sbjct: 1087 IMDYIFSPEEIIFIIQNLLIQ--ILCSIGYVSSLVF----LTYV---------------I 1125
Query: 1810 TFILELFENNRTLLRFNAVLRKLLIVFPHFCLGRGLIDLALSQAVTDVYARFGEEH---S 1866
+FI N + F ++ + + G + L + + G
Sbjct: 1126 SFIFRNGRKNSGIWSFFFLIVVIFSIVATDLNEYGFLGLFFGTMLIPPFTLIGSLFIFSE 1185
Query: 1867 ANPFHWDLIGKNLFAMVVEGVVYFLLTLLVQRHFFLSQWIAE------------------ 1908
+P D +G + E + +L L+ HF + +I
Sbjct: 1186 ISPDSMDYLGAS------ESEIVYLALLIPYLHFLIFLFILRCLEMNCRKKLMRKDPVFR 1239
Query: 1909 ---------PTKEPIVDEDDDVAEERQRIITGG-----NKTDILRLHELTKIYPGTSSP- 1953
P E E++D+ ER R + ++T ++ L K Y G
Sbjct: 1240 ISPRSNAIFPNPEEPEGEEEDIQMERMRTVNAMAVRDFDETPVIIASCLRKEYAGKKKNC 1299
Query: 1954 --------AVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILT 2005
A + V+ GE GLLG NGAGK+TT KM+TGDT T+G + G +
Sbjct: 1300 FSKRKKKIATRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKG----S 1355
Query: 2006 NISEVHQNMGYCPQFDAIDELLTGREHLYLYARLRGVPAEEIEKVANWSIKSLGLTVYAD 2065
E +GYCPQ +A+ LT R+HL +YA ++G+ + + +L L
Sbjct: 1356 GGGEPLGFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLK 1415
Query: 2066 CLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREG-RAVV 2124
T S G KRKL ++++G P +VLLDEP+TGMDP+ ++ +W VI + R R +
Sbjct: 1416 APVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGAL 1475
Query: 2125 LTSHSMEECEALCTRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKIKSPKDDLLPDLNP 2184
LT+H M E EA+C R+AIMV G RC+G+IQHLKSKFG Y++ MK+K+ L + P
Sbjct: 1476 LTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKLKN-----LAQMEP 1530
Query: 2185 VEQFFQGNFPGSVQRERHYNMLQFQVSSSS---LARIFQLLLSHKDSLLIEEYSVTQTTL 2241
+ FP + Q+ER +++ +++ L++ F L K S +EEYS++Q+TL
Sbjct: 1531 LHAEILRLFPQAAQQERFSSLMVYKLPVEDVRPLSQAFFKLEIVKQSFDLEEYSLSQSTL 1590
Query: 2242 DQVFVNFAKQQ 2252
+QVF+ +K+Q
Sbjct: 1591 EQVFLELSKEQ 1601
Score = 159 bits (402), Expect = 3e-38
Identities = 158/627 (25%), Positives = 279/627 (44%), Gaps = 69/627 (11%)
Query: 1666 EQLSEITVLTTSVDAVVA---ICVIFSMSFVPASFVLYLIQERVNKSKHLQFIS------ 1716
EQL +T + + VA + F + F SF ++ VN ++ Q+I+
Sbjct: 200 EQLMSVTGVHMKILPFVAQGGVATDFFIFFCIISFSTFIYYVSVNVTQERQYITSLMTMM 259
Query: 1717 GVSPTTYWVTNFLWDIMNYS---VSAGLVVGIFIGFQKKAYTSPENLPALVALLLLYGWA 1773
G+ + +W++ W +M + A L+ I Q T + L LLYG +
Sbjct: 260 GLRESAFWLS---WGLMYAGFILIMATLMALIVKSAQIVVLTG---FVMVFTLFLLYGLS 313
Query: 1774 VIPMMYPASFLFDVPSTAYVALSCANLFIGINSSAITFILELFENNRTLLRFNAVLRKLL 1833
+I + + S L P + + +F GI + R A L L
Sbjct: 314 LITLAFLMSVLIKKPFLTGLVVFLLIVFWGILGFPALYT-----------RLPAFLEWTL 362
Query: 1834 IVFPHFCLGRGLIDLALSQAVTDVYARFGEEHSANPFHWDLIGKNLFAMVVEGVVYFLLT 1893
+ F G+ L DV + + S NP+ LI LF +V + ++Y +LT
Sbjct: 363 CLLSPFAFTVGMAQLI--HLDYDVNSNAHLDSSQNPY---LIIATLFMLVFDTLLYLVLT 417
Query: 1894 LLVQRH------------FFLSQ--WIAEPTKEPIVDEDDDVAEER-----QRIITGGNK 1934
L + FFL W +V E++ ++ + +
Sbjct: 418 LYFDKILPAEYGHRCSPLFFLKSCFWFQHGRANHVVLENETDSDPTPNDCFEPVSPEFCG 477
Query: 1935 TDILRLHELTKIYPGTSS--PAVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVT 1992
+ +R+ L K Y G A+ + + G+ LLG +GAGKTT +L+G + T
Sbjct: 478 KEAIRIKNLKKEYAGKCERVEALKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPT 537
Query: 1993 SGDATVAGKSI--LTNISEVHQNMGYCPQFDAIDELLTGREHLYLYARLRGVPAEEIEKV 2050
SG TV ++ + +I + + G+CPQ + LT +E+L L+A+++G+ E+EK
Sbjct: 538 SGSVTVYNHTLSRMADIENISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEKE 597
Query: 2051 ANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLW 2110
++ L + D LA SGG RKL+ IA++G P ++LLDEPT G+DP +R +W
Sbjct: 598 VQRVVQELEMENIQDILAQNLSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIW 657
Query: 2111 NVIVSIIREG---RAVVLTSHSMEECEALCTRLAIMVKGAFRCMGTIQHLKSKFGDGYIV 2167
N +++EG R ++ ++ ++E + L R + G +C G+ LK K+G GY +
Sbjct: 658 N----LLKEGKSDRVILFSTQFIDEADILADRKVFISNGKLKCAGSSLFLKKKWGIGYHL 713
Query: 2168 TMKIKSPKD-DLLPDLNPVEQFFQGNFPGSVQRERHYNMLQFQVSSSSLARIFQLLLSHK 2226
++ + D + + L V+Q + E+ +L + ++ +++ L
Sbjct: 714 SLHLNERCDPESITSL--VKQHISDAKLTAQSEEKLVYILPLE-RTNKFPELYR-DLDRC 769
Query: 2227 DSLLIEEYSVTQTTLDQVFVNFAKQQT 2253
+ IE+Y V+ TTL++VF+ + T
Sbjct: 770 SNQGIEDYGVSITTLNEVFLKLEGKST 796
Score = 150 bits (380), Expect = 1e-35
Identities = 97/340 (28%), Positives = 173/340 (50%), Gaps = 48/340 (14%)
Query: 950 NITFY--ENQITAFLGHNGAGKTTTLSILTGLLPPTSGTVLVGGRDIETSLDAVRQSLGM 1007
N++F + ++ LGHNGAGK+TT+ ++TG PT+G V++ G L LG
Sbjct: 1311 NVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGSGGGEPLGF----LGY 1366
Query: 1008 CPQHNILFHHLTVAEHMLFYAQLKGKSQEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQ 1067
CPQ N L+ +LTV +H+ YA +KG + +A + + +++ L + + LS G++
Sbjct: 1367 CPQENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLKAPVKTLSEGIK 1426
Query: 1068 RKLSVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLK--YRSGRTIIMSTHHMDEADL 1125
RKL ++ +G+ VV+LDEP++G+DP ++ +W ++ + R +++TH+M EA+
Sbjct: 1427 RKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTTHYMAEAEA 1486
Query: 1126 LGDRIAIIAQGRLYCSGTPLFLKNCFGTGLYLTLVRKMKNIQSQRKGSEGTCSCSSKGFS 1185
+ DR+AI+ GRL C G+ LK+ FG L + K+KN+
Sbjct: 1487 VCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEM--KLKNLAQME--------------- 1529
Query: 1186 TTCPAHVDDLTPEQVLDGDVNELMDVVLHHVPEAKLVECIGQELIFLLPNKNFKHRAYAS 1245
P H + +L P+A E +++ LP ++ R +
Sbjct: 1530 ---PLHAE------------------ILRLFPQAAQQERFSSLMVYKLPVEDV--RPLSQ 1566
Query: 1246 LFRELEETLADLGLSSFGISDTPLEEIFLKVTEDSDSGPL 1285
F +LE L + +S + LE++FL+++++ + G L
Sbjct: 1567 AFFKLEIVKQSFDLEEYSLSQSTLEQVFLELSKEQELGDL 1606
>gi|153792144 ATP-binding cassette, sub-family A, member 10 [Homo
sapiens]
Length = 1543
Score = 250 bits (638), Expect = 1e-65
Identities = 199/761 (26%), Positives = 356/761 (46%), Gaps = 95/761 (12%)
Query: 550 GVVFPDMYPWTSSLPPHVKYKIRMDIDVVEKTNKIKDRYWDSGPRADPVEDFRYI---W- 605
GV+F D + + +K+ I V+++ ++ + W A E F Y+ W
Sbjct: 37 GVIFSDTFSY------RLKFNWGYRIPVIKEHSEYTEHCW-----AMHGEIFCYLAKYWL 85
Query: 606 GGFAYLQDMVEQGI----TRSQVQAE--APVGIYLQQMPYPCFVDDSFMIILNRCFPIFM 659
GF Q + I T V E + +GI M P F+ I+N F
Sbjct: 86 KGFVAFQAAINAAIIEVTTNHSVMEELTSVIGI---NMKIPPFISKGE--IMNEWFHFTC 140
Query: 660 VLAWIYSVSMTVKSIVLEKELRLKETLKNQGVSNAVIWCTWFLDSFSIMSMSIFLLTIFI 719
++++ + ++ E+ + K+ + G+ + W +W L + + + + I
Sbjct: 141 LVSFSSFIYFASLNVARERG-KFKKLMTVMGLRESAFWLSWGLTYICFIFIMSIFMALVI 199
Query: 720 MHGRILHYSDPFILFLFLLAFSTATIMLCFLLSTFFSKASLAAACSGVIYFTLYLPHILC 779
I+ ++ ++F + + I L FL+S K LA FT++ +
Sbjct: 200 TSIPIVFHTGFMVIFTLYSLYGLSLIALAFLMSVLIRKPMLAGLAG--FLFTVFWGCLGF 257
Query: 780 FAWQDRMTAELKKAVSLLSPVAFGFGTEYLVRFEEQGLGLQWSNIGNSPTEGDEFSFLLS 839
++ L +SLLSP AF G + + G+ + + GD + + +
Sbjct: 258 TVLYRQLPLSLGWVLSLLSPFAFTAGMAQITHLDNYLSGVIFPD-----PSGDSYKMIAT 312
Query: 840 MQMMLLDAAVYGLLAWYLDQVFPGDYGTPLPWYFLLQESYWLGGEGCSTREERALEKTEP 899
++ D Y + Y ++V P G F L+ S+W + +T E
Sbjct: 313 FFILAFDTLFYLIFTLYFERVLPDKDGHGDSPLFFLKSSFWSKHQ--NTHHE-------- 362
Query: 900 LTEETEDPEHPEGIHDSFFEREHPGW--VPGVCVKNLVKIFE-PCGR-PAVDRLNITFYE 955
+ E +PEH D FE P + + ++N++K + G+ A+ + YE
Sbjct: 363 IFENEINPEHSS---DDSFEPVSPEFHGKEAIRIRNVIKEYNGKTGKVEALQGIFFDIYE 419
Query: 956 NQITAFLGHNGAGKTTTLSILTGLLPPTSGTVLVGGRDIE--TSLDAVRQSLGMCPQHNI 1013
QITA LGHNGAGK+T L+IL+GL T G+ + + T ++ +R+++G CPQ N
Sbjct: 420 GQITAILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQLSEITDMEEIRKNIGFCPQFNF 479
Query: 1014 LFHHLTVAEHMLFYAQLKGKSQEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVA 1073
F LTV E++ +A++KG +E + E++ ++ + + ++ A+ LSGG +RKL++
Sbjct: 480 QFDFLTVRENLRVFAKIKGIQPKEVEQEVKRIIMELDMQSIQDIIAKKLSGGQKRKLTLG 539
Query: 1074 IAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIAII 1133
IA +GD +V++LDEPT+G+DP+SR +W LL +++ R I+ ST MDEAD+L DR +
Sbjct: 540 IAILGDPQVLLLDEPTAGLDPFSRHRVWSLLKEHKVDRLILFSTQFMDEADILADRKVFL 599
Query: 1134 AQGRLYCSGTPLFLKNCFGTGLYLTLVRKMKNIQSQRKGSEGTCSCSSKGFSTTCPAHVD 1193
+ G+L C+G+ LFLK +G G +L+L R + C
Sbjct: 600 SNGKLKCAGSSLFLKRKWGIGYHLSLHR-----------------------NEMC----- 631
Query: 1194 DLTPEQVLDGDVNELMDVVLHHVPEAKLVECIGQELIFLLPNKNFKHRAYASLFRELEET 1253
D ++ ++ H+P+AKL ++L++ LP + K + L+ +L++
Sbjct: 632 ----------DTEKITSLIKQHIPDAKLTTESEEKLVYSLPLE--KTNKFPDLYSDLDK- 678
Query: 1254 LADLGLSSFGISDTPLEEIFLKVT-EDSDSGPLFAGGAQQK 1293
+D G+ ++ +S T L E+FL + + + P F G Q+K
Sbjct: 679 CSDQGIRNYAVSVTSLNEVFLNLEGKSAIDEPDFDIGKQEK 719
Score = 208 bits (530), Expect = 4e-53
Identities = 179/623 (28%), Positives = 302/623 (48%), Gaps = 84/623 (13%)
Query: 1686 VIFSMSFVPASFVLYLIQERVNK----------SKHLQ---FISGVSPTTYWVTNFLWDI 1732
++ + F+ S L LI V+ K++Q +ISG+ P+ YW L DI
Sbjct: 926 IVLDLGFIDGSIFLLLITNCVSPFIGMSSISDYKKNVQSQLWISGLWPSAYWCGQALVDI 985
Query: 1733 MNYSV---SAGLVVG-IFIGFQKKAYTSPENLPALVALLLLYGWAVIPMMYPASFLFDV- 1787
Y + S L+ IF+GFQ S E + LV ++ ++I + Y SF+F
Sbjct: 986 PLYFLILFSIHLIYYFIFLGFQ----LSWELMFVLVVCIIGCAVSLIFLTYVLSFIFRKW 1041
Query: 1788 -PSTAYVALSCANLFIGINSSAITFILELFENNRTLLRFNAVLRKLLIVFPHFCL---GR 1843
+ + + + I +++ ++ E + N +L +I P F L
Sbjct: 1042 RKNNGFWSFGFFIILICVSTIMVSTQYE---------KLNLIL--CMIFIPSFTLLGYVM 1090
Query: 1844 GLIDLALSQAVTDVYARFGEEHSANPFHWDLIGKNLFAMVVEGVVYFLLTLLVQRH---- 1899
LI L + + + R E + ++ L + + F++ L ++
Sbjct: 1091 LLIQLDFMRNLDSLDNRINEVNKT------ILLTTLIPYLQSVIFLFVIRCLEMKYGNEI 1144
Query: 1900 ------FFLSQWIAE--PTKEPIVDEDDDVAEERQRI---ITGGNKTD--ILRLHELTKI 1946
F +S E P E +ED+DV ER + +T N + ++ L K
Sbjct: 1145 MNKDPVFRISPRSRETHPNPEEPEEEDEDVQAERVQAANALTAPNLEEEPVITASCLHKE 1204
Query: 1947 YPGTSSP---------AVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDAT 1997
Y T A+ + V+ GE GLLG NGAGK+T+ KM+TG T T+G
Sbjct: 1205 YYETKKSCFSTRKKKIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTAGVVV 1264
Query: 1998 VAGKSILTNISEVHQN----MGYCPQFDAIDELLTGREHLYLYARLRGVPAEEIEKVANW 2053
+ G ++ + H N +GYCPQ +++ LT +EHL LYA ++G+ E+ +
Sbjct: 1265 LQGSR--ASVRQQHDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVKGLGKEDAALSISR 1322
Query: 2054 SIKSLGLTVYADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVI 2113
+++L L T S G KRKL ++++G P +VLLDEP TGMDP+ ++ +W ++
Sbjct: 1323 LVEALKLQEQLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQIL 1382
Query: 2114 VSIIR-EGRAVVLTSHSMEECEALCTRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKIK 2172
+ ++ + R +LT+H M E EA+C R+A+MV G RC+G+IQHLK+KFG Y++ +K+K
Sbjct: 1383 QATVKNKERGTLLTTHYMSEAEAVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEIKMK 1442
Query: 2173 SPKDDLLPDLNPVEQFFQGNFPGSVQRERHYNMLQFQVSSSS---LARIFQLLLSHKDSL 2229
P + + FP + +ER+ +++ +++ L+R F L + K +
Sbjct: 1443 EP-----TQVEALHTEILKLFPQAAWQERYSSLMAYKLPVEDVHPLSRAFFKLEAMKQTF 1497
Query: 2230 LIEEYSVTQTTLDQVFVNFAKQQ 2252
+EEYS++Q TL+QVF+ K+Q
Sbjct: 1498 NLEEYSLSQATLEQVFLELCKEQ 1520
Score = 151 bits (382), Expect = 6e-36
Identities = 92/319 (28%), Positives = 168/319 (52%), Gaps = 14/319 (4%)
Query: 1936 DILRLHELTKIYPGTSSP--AVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTS 1993
+ +R+ + K Y G + A+ + + G+ +LG NGAGK+T +L+G + T
Sbjct: 389 EAIRIRNVIKEYNGKTGKVEALQGIFFDIYEGQITAILGHNGAGKSTLLNILSGLSVSTE 448
Query: 1994 GDATVAGKSI--LTNISEVHQNMGYCPQFDAIDELLTGREHLYLYARLRGVPAEEIEKVA 2051
G AT+ + +T++ E+ +N+G+CPQF+ + LT RE+L ++A+++G+ +E+E+
Sbjct: 449 GSATIYNTQLSEITDMEEIRKNIGFCPQFNFQFDFLTVRENLRVFAKIKGIQPKEVEQEV 508
Query: 2052 NWSIKSLGLTVYADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWN 2111
I L + D +A SGG KRKL+ IA++G P ++LLDEPT G+DP +R +W+
Sbjct: 509 KRIIMELDMQSIQDIIAKKLSGGQKRKLTLGIAILGDPQVLLLDEPTAGLDPFSRHRVWS 568
Query: 2112 VIVSIIREGRAVVLTSHSMEECEALCTRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKI 2171
++ + R ++ ++ M+E + L R + G +C G+ LK K+G GY +++
Sbjct: 569 LLKE-HKVDRLILFSTQFMDEADILADRKVFLSNGKLKCAGSSLFLKRKWGIGYHLSLHR 627
Query: 2172 KSPKDDLLPDLNPVEQFFQGNFPGSVQRERHYNMLQFQVSSSSLARIFQLLLSHKDSLL- 2230
+ D + + + P + L + + + F L S D
Sbjct: 628 NE-----MCDTEKITSLIKQHIPDAKLTTESEEKLVYSLPLEKTNK-FPDLYSDLDKCSD 681
Query: 2231 --IEEYSVTQTTLDQVFVN 2247
I Y+V+ T+L++VF+N
Sbjct: 682 QGIRNYAVSVTSLNEVFLN 700
Score = 150 bits (378), Expect = 2e-35
Identities = 99/343 (28%), Positives = 168/343 (48%), Gaps = 44/343 (12%)
Query: 945 AVDRLNITFYENQITAFLGHNGAGKTTTLSILTGLLPPTSGTVLVGGR--DIETSLDAVR 1002
A+ ++ + ++ LGHNGAGK+T++ ++TG PT+G V++ G + D
Sbjct: 1221 AIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTAGVVVLQGSRASVRQQHDNSL 1280
Query: 1003 QSLGMCPQHNILFHHLTVAEHMLFYAQLKGKSQEEAQLEMEAMLEDTGLHHKRNEEAQDL 1062
+ LG CPQ N L+ LT+ EH+ YA +KG +E+A L + ++E L + + L
Sbjct: 1281 KFLGYCPQENSLWPKLTMKEHLELYAAVKGLGKEDAALSISRLVEALKLQEQLKAPVKTL 1340
Query: 1063 SGGMQRKLSVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLL--LKYRSGRTIIMSTHHM 1120
S G++RKL ++ +G+ VV+LDEP +G+DP ++ +W +L R +++TH+M
Sbjct: 1341 SEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKERGTLLTTHYM 1400
Query: 1121 DEADLLGDRIAIIAQGRLYCSGTPLFLKNCFGTGLYLTLVRKMKNIQSQRKGSEGTCSCS 1180
EA+ + DR+A++ G L C G+ LKN FG L + KMK
Sbjct: 1401 SEAEAVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEI--KMKE--------------- 1443
Query: 1181 SKGFSTTCPAHVDDLTPEQVLDGDVNELMDVVLHHVPEAKLVECIGQELIFLLPNKNFKH 1240
P V+ L E +L P+A E + + LP ++
Sbjct: 1444 --------PTQVEALHTE-------------ILKLFPQAAWQERYSSLMAYKLPVEDVHP 1482
Query: 1241 RAYASLFRELEETLADLGLSSFGISDTPLEEIFLKVTEDSDSG 1283
+ A F +LE L + +S LE++FL++ ++ + G
Sbjct: 1483 LSRA--FFKLEAMKQTFNLEEYSLSQATLEQVFLELCKEQELG 1523
>gi|6005701 ATP-binding cassette, sub-family A member 8 [Homo sapiens]
Length = 1581
Score = 224 bits (572), Expect = 6e-58
Identities = 183/685 (26%), Positives = 309/685 (45%), Gaps = 125/685 (18%)
Query: 607 GFAYLQDMVEQGI---TRSQVQAEAPVGIYLQQMPYPCFVDDSFMII---LNRCFPIFMV 660
GF LQ + I T + E + + + M F+ S +I L C F
Sbjct: 176 GFVALQAAINAAIIEITTNHSVMEELMSVTGKNMKMHSFIGQSGVITDLYLFSCIISFSS 235
Query: 661 LAWIYSVSMTVKSIVLEKELRLKETLKNQGVSNAVIWCTWFLDSFSIMSMSIFLLTIFIM 720
+ SV++T + R+K + G+ ++ W +W L + + L + I
Sbjct: 236 FIYYASVNVT------RERKRMKALMTMMGLRDSAFWLSWGLLYAGFIFIMALFLALVIR 289
Query: 721 HGRILHYSDPFILFLFLLAFSTATIMLCFLLSTFFSKASLAAACSGVIYFTLYLPHILCF 780
+ + S ++F L + + + L FL+S K+ L V T++ +
Sbjct: 290 STQFIILSGFMVVFSLFLLYGLSLVALAFLMSILVKKSFLTGLV--VFLLTVFWGCLGFT 347
Query: 781 AWQDRMTAELKKAVSLLSPVAFGFGTEYLVRFEEQGLGLQWSNIGNSPTEGDEFSFLLSM 840
+ + A L+ +SLLSP AF G L+ + N P D + +++
Sbjct: 348 SLYRHLPASLEWILSLLSPFAFMLGMAQLLHLDYD------LNSNAFPHPSDGSNLIVAT 401
Query: 841 QMML-LDAAVYGLLAWYLDQVFPGDYGTPLPWYFLLQESYWLGGEGCSTREERALEKTEP 899
ML D +Y LA Y +++ P +YG P F L+ S+W +KT+
Sbjct: 402 NFMLAFDTCLYLALAIYFEKILPNEYGHRRPPLFFLKSSFW-----------SQTQKTDH 450
Query: 900 LTEETEDPEHPEGIHDSFFEREHPGWV--PGVCVKNLVKIFEPCGRP----AVDRLNITF 953
+ E E P HDSF E+ P + + ++N+ K ++ G+P A+ L
Sbjct: 451 VALEDEMDADPS-FHDSF-EQAPPEFQGKEAIRIRNVTKEYK--GKPDKIEALKDLVFDI 506
Query: 954 YENQITAFLGHNGAGKTTTLSILTGLLPPTSGTVLVGGRDIE--TSLDAVRQSLGMCPQH 1011
YE QITA LGH+GAGK+T L+IL+GL PT G+V + + L+ + + G+CPQ
Sbjct: 507 YEGQITAILGHSGAGKSTLLNILSGLSVPTKGSVTIYNNKLSEMADLENLSKLTGVCPQS 566
Query: 1012 NILFHHLTVAEHMLFYAQLKGKSQEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLS 1071
N+ F LTV E++ +A++KG +E
Sbjct: 567 NVQFDFLTVRENLRLFAKIKGILPQEV--------------------------------- 593
Query: 1072 VAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIA 1131
D ++ +LDEPT+G+DP+SR +W+LL + ++ R I+ ST MDEAD+L DR
Sbjct: 594 -------DKEIFLLDEPTAGLDPFSRHQVWNLLKERKTDRVILFSTQFMDEADILADRKV 646
Query: 1132 IIAQGRLYCSGTPLFLKNCFGTGLYLTLVRKMKNIQSQRKGSEGTCSCSSKGFSTTCPAH 1191
++QG+L C+G+ LFLK +G G +L+L
Sbjct: 647 FLSQGKLKCAGSSLFLKKKWGIGYHLSL-------------------------------Q 675
Query: 1192 VDDLTPEQVLDGDVNELMDVVLHHVPEAKLVECIGQELIFLLPNKNFKHRAYASLFRELE 1251
++++ E+ + +V H+P+AKL +LI+ LP + + + L+++L
Sbjct: 676 LNEICVEE-------NITSLVKQHIPDAKLSAKSEGKLIYTLPLE--RTNKFPELYKDL- 725
Query: 1252 ETLADLGLSSFGISDTPLEEIFLKV 1276
++ DLG+ ++G+S T L E+FLK+
Sbjct: 726 DSYPDLGIENYGVSMTTLNEVFLKL 750
Score = 219 bits (557), Expect = 3e-56
Identities = 180/600 (30%), Positives = 287/600 (47%), Gaps = 72/600 (12%)
Query: 1691 SFVPASFVLYLIQERVNKSKHLQFISGVSPTTYWVTNFLWDIMNYSVSAGLVVGIFIGFQ 1750
S P + I + N+++ ISG+SP+ YW L D+ Y +V +FI
Sbjct: 993 SSCPPYIAMSSIDDYKNRARSQLRISGLSPSAYWFGQALVDVSLY-----FLVFVFIYLM 1047
Query: 1751 KKAYTSPENLPALVALLLL-----YGWAVIPMMYPASFLFDVPSTAYVALSCANLFIGIN 1805
+ L ++ ++ + Y +++I M Y SF+F S + +
Sbjct: 1048 SYISNFEDMLLTIIHIIQIPCAVGYSFSLIFMTYVISFIFRKGRKNSGIWSFCFYVVTVF 1107
Query: 1806 SSAITFILELFENNRTLLRFNAVLRKLLIVFPHFCLGRGLIDLALSQAVTDVYARFGEEH 1865
S A F +FE++ + F ++ ++ F L S+ DV
Sbjct: 1108 SVA-GFAFSIFESDIPFI-FTFLIPPATMIGCLFLSSHLLFSSLFSEERMDV-------- 1157
Query: 1866 SANPFHWDLIGKNLFAMVVEGVVYFLLTL-----------LVQRHFFL----SQWIAEPT 1910
PF +F + + FL TL + + FF S + +
Sbjct: 1158 --QPFL-------VFLIPFLHFIIFLFTLRCLEWKFGKKSMRKDPFFRISPRSSDVCQNP 1208
Query: 1911 KEPIVDEDDDVAEERQRIITGGNKTD-----ILRLHELTKIYPGT---------SSPAVD 1956
+EP ED+DV ER R N T+ ++ L K Y G + A
Sbjct: 1209 EEP-EGEDEDVQMERVRTANALNSTNFDEKPVIIASCLRKEYAGKRKGCFSKRKNKIATR 1267
Query: 1957 RLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNISEVHQNMGY 2016
+ VR GE GLLG NGAGK+T+ K++TGDT T+G + G + + + +GY
Sbjct: 1268 NVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKG----SGGGDALEFLGY 1323
Query: 2017 CPQFDAIDELLTGREHLYLYARLRGVPAEEIEKVANWSIKSLGLTVYADCLAGTYSGGNK 2076
CPQ +A+ LT R+HL +YA ++G+ + E + +L L T S G K
Sbjct: 1324 CPQENALWPNLTVRQHLEVYAAVKGLRKGDAEVAITRLVDALKLQDQLKSPVKTLSEGIK 1383
Query: 2077 RKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIRE-GRAVVLTSHSMEECEA 2135
RKL ++++G P +VLLDEP+TGMDP+ ++ +W I + R R +LT+H M E EA
Sbjct: 1384 RKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLTTHYMAEAEA 1443
Query: 2136 LCTRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKIKSPKDDLLPDLNPVEQFFQGNFPG 2195
+C R+AIMV G RC+G+IQHLKSKFG Y++ MK+K+ L + P+ FP
Sbjct: 1444 VCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKVKN-----LAQVEPLHAEILRLFPQ 1498
Query: 2196 SVQRERHYNMLQFQV---SSSSLARIFQLLLSHKDSLLIEEYSVTQTTLDQVFVNFAKQQ 2252
+ ++ER+ +++ +++ LA+ F L K S +EEYS++Q+TL+QVF+ +K+Q
Sbjct: 1499 AARQERYSSLMVYKLPVEDVQPLAQAFFKLEKVKQSFDLEEYSLSQSTLEQVFLELSKEQ 1558
Score = 153 bits (386), Expect = 2e-36
Identities = 114/403 (28%), Positives = 197/403 (48%), Gaps = 56/403 (13%)
Query: 883 GEGCSTREERALEKTEPLTEETEDPEHPEGIHDSFFEREHPGWVPGVCVKNLVKIFEPCG 942
GE + ER +T T E P I S +E+ G G K KI
Sbjct: 1213 GEDEDVQMERV--RTANALNSTNFDEKPV-IIASCLRKEYAGKRKGCFSKRKNKI----- 1264
Query: 943 RPAVDRLNITFYENQITAFLGHNGAGKTTTLSILTGLLPPTSGTVLVGGRDIETSLDAVR 1002
A ++ + ++ LGHNGAGK+T++ ++TG PT+G VL+ G +L+
Sbjct: 1265 --ATRNVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKGSGGGDALEF-- 1320
Query: 1003 QSLGMCPQHNILFHHLTVAEHMLFYAQLKGKSQEEAQLEMEAMLEDTGLHHKRNEEAQDL 1062
LG CPQ N L+ +LTV +H+ YA +KG + +A++ + +++ L + + L
Sbjct: 1321 --LGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAEVAITRLVDALKLQDQLKSPVKTL 1378
Query: 1063 SGGMQRKLSVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLK--YRSGRTIIMSTHHM 1120
S G++RKL ++ +G+ VV+LDEP++G+DP ++ +W + + R +++TH+M
Sbjct: 1379 SEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLTTHYM 1438
Query: 1121 DEADLLGDRIAIIAQGRLYCSGTPLFLKNCFGTGLYLTLVRKMKNIQSQRKGSEGTCSCS 1180
EA+ + DR+AI+ GRL C G+ LK+ FG L + K+KN+
Sbjct: 1439 AEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEM--KVKNL-------------- 1482
Query: 1181 SKGFSTTCPAHVDDLTPEQVLDGDVNELMDVVLHHVPEAKLVECIGQELIFLLPNKNFKH 1240
A V+ L E +L P+A E +++ LP ++ +
Sbjct: 1483 ---------AQVEPLHAE-------------ILRLFPQAARQERYSSLMVYKLPVEDVQP 1520
Query: 1241 RAYASLFRELEETLADLGLSSFGISDTPLEEIFLKVTEDSDSG 1283
A A F +LE+ L + +S + LE++FL+++++ + G
Sbjct: 1521 LAQA--FFKLEKVKQSFDLEEYSLSQSTLEQVFLELSKEQELG 1561
Score = 106 bits (265), Expect = 2e-22
Identities = 118/607 (19%), Positives = 242/607 (39%), Gaps = 105/607 (17%)
Query: 1681 VVAICVIFSMSFVPASFVLYL---IQERVNKSKHLQFISGVSPTTYWVTNFLWDIMNYSV 1737
V+ +FS +SF+ Y + + K L + G+ + +W++ W ++
Sbjct: 220 VITDLYLFSCIISFSSFIYYASVNVTRERKRMKALMTMMGLRDSAFWLS---WGLLYAGF 276
Query: 1738 SAGLVVGIFIGFQKKAYTSPENLPALVALLLLYGWAVIPMMYPASFLFDVPSTAYVALSC 1797
+ + + + + + + +L LLYG +++ + + S L + +
Sbjct: 277 IFIMALFLALVIRSTQFIILSGFMVVFSLFLLYGLSLVALAFLMSILVKKSFLTGLVVFL 336
Query: 1798 ANLFIGINSSAITFILELFENNRTLLRFNAVLRKLLIVFPHFCLGRGLIDLALSQAVTDV 1857
+F G + A L +L + F G+ L
Sbjct: 337 LTVFWGCLGFTSLY-----------RHLPASLEWILSLLSPFAFMLGMAQLL-------- 377
Query: 1858 YARFGEEHSANPFHWDLIGKNL-----FAMVVEGVVYFLLTLLVQRH------------F 1900
+ ++N F G NL F + + +Y L + ++ F
Sbjct: 378 --HLDYDLNSNAFPHPSDGSNLIVATNFMLAFDTCLYLALAIYFEKILPNEYGHRRPPLF 435
Query: 1901 FLSQWIAEPTK-------EPIVDEDDDVAEERQRIITGGNKTDILRLHELTKIYPGTSSP 1953
FL T+ E +D D + ++ + +R+ +TK Y G
Sbjct: 436 FLKSSFWSQTQKTDHVALEDEMDADPSFHDSFEQAPPEFQGKEAIRIRNVTKEYKGKPDK 495
Query: 1954 --AVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSI--LTNISE 2009
A+ L + G+ +LG +GAGK+T +L+G + T G T+ + + ++
Sbjct: 496 IEALKDLVFDIYEGQITAILGHSGAGKSTLLNILSGLSVPTKGSVTIYNNKLSEMADLEN 555
Query: 2010 VHQNMGYCPQFDAIDELLTGREHLYLYARLRGVPAEEIEKVANWSIKSLGLTVYADCLAG 2069
+ + G CPQ + + LT RE+L L+A+++G+ +E++K
Sbjct: 556 LSKLTGVCPQSNVQFDFLTVRENLRLFAKIKGILPQEVDK-------------------- 595
Query: 2070 TYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSHS 2129
+ LLDEPT G+DP +R +WN++ + R ++ ++
Sbjct: 596 --------------------EIFLLDEPTAGLDPFSRHQVWNLLKER-KTDRVILFSTQF 634
Query: 2130 MEECEALCTRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKIKSPKDDLLPDLNPVEQFF 2189
M+E + L R + +G +C G+ LK K+G GY +++++ +++ + N +
Sbjct: 635 MDEADILADRKVFLSQGKLKCAGSSLFLKKKWGIGYHLSLQL----NEICVEEN-ITSLV 689
Query: 2190 QGNFPGSVQRERHYNMLQFQV---SSSSLARIFQLLLSHKDSLLIEEYSVTQTTLDQVFV 2246
+ + P + + L + + ++ +++ L S+ D L IE Y V+ TTL++VF+
Sbjct: 690 KQHIPDAKLSAKSEGKLIYTLPLERTNKFPELYKDLDSYPD-LGIENYGVSMTTLNEVFL 748
Query: 2247 NFAKQQT 2253
+ T
Sbjct: 749 KLEGKST 755
>gi|169210363 PREDICTED: similar to hCG18626 [Homo sapiens]
Length = 171
Score = 165 bits (417), Expect = 5e-40
Identities = 86/169 (50%), Positives = 117/169 (69%), Gaps = 5/169 (2%)
Query: 2027 LTGREHLYLYARLRGVPAEEIEKVANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAIALI 2086
+T +E + +YAR+ GV +I N + SL L +A L TYS GNKR+LSTAIAL+
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 2087 GCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSHSMEECEALCTRLAIMVKG 2146
G ++ LDEP+TGMDP ARR+LWN++ G+A+V+TSHSMEEC+ALCT LAIMV+G
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 2147 AFRCMGTIQHLKSKFGDGYIVTMKIKSPKDDLLPDLNPVEQFFQGNFPG 2195
F C+G+ QHLKSKFG+ YI+ +K+K+ +D L D + + FPG
Sbjct: 121 KFTCLGSPQHLKSKFGNIYILKVKVKT--EDKLEDF---KCYVATTFPG 164
Score = 100 bits (250), Expect = 1e-20
Identities = 54/145 (37%), Positives = 87/145 (60%), Gaps = 2/145 (1%)
Query: 1018 LTVAEHMLFYAQLKGKSQEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVAIAFV 1077
+T E M+ YA++ G S+ + L + L L S G +R+LS AIA +
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 1078 GDAKVVILDEPTSGVDPYSRRSIWDLLLKYR-SGRTIIMSTHHMDEADLLGDRIAIIAQG 1136
G + V+ LDEP++G+DP +RR +W+++ K R SG+ I+M++H M+E D L +AI+ QG
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 1137 RLYCSGTPLFLKNCFGTGLYLTLVR 1161
+ C G+P LK+ FG +Y+ V+
Sbjct: 121 KFTCLGSPQHLKSKFG-NIYILKVK 144
>gi|169210679 PREDICTED: similar to hCG18626 [Homo sapiens]
Length = 171
Score = 165 bits (417), Expect = 5e-40
Identities = 86/169 (50%), Positives = 117/169 (69%), Gaps = 5/169 (2%)
Query: 2027 LTGREHLYLYARLRGVPAEEIEKVANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAIALI 2086
+T +E + +YAR+ GV +I N + SL L +A L TYS GNKR+LSTAIAL+
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 2087 GCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSHSMEECEALCTRLAIMVKG 2146
G ++ LDEP+TGMDP ARR+LWN++ G+A+V+TSHSMEEC+ALCT LAIMV+G
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 2147 AFRCMGTIQHLKSKFGDGYIVTMKIKSPKDDLLPDLNPVEQFFQGNFPG 2195
F C+G+ QHLKSKFG+ YI+ +K+K+ +D L D + + FPG
Sbjct: 121 KFTCLGSPQHLKSKFGNIYILKVKVKT--EDKLEDF---KCYVATTFPG 164
Score = 100 bits (250), Expect = 1e-20
Identities = 54/145 (37%), Positives = 87/145 (60%), Gaps = 2/145 (1%)
Query: 1018 LTVAEHMLFYAQLKGKSQEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVAIAFV 1077
+T E M+ YA++ G S+ + L + L L S G +R+LS AIA +
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 1078 GDAKVVILDEPTSGVDPYSRRSIWDLLLKYR-SGRTIIMSTHHMDEADLLGDRIAIIAQG 1136
G + V+ LDEP++G+DP +RR +W+++ K R SG+ I+M++H M+E D L +AI+ QG
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 1137 RLYCSGTPLFLKNCFGTGLYLTLVR 1161
+ C G+P LK+ FG +Y+ V+
Sbjct: 121 KFTCLGSPQHLKSKFG-NIYILKVK 144
>gi|169209894 PREDICTED: similar to hCG18626 [Homo sapiens]
Length = 171
Score = 165 bits (417), Expect = 5e-40
Identities = 86/169 (50%), Positives = 117/169 (69%), Gaps = 5/169 (2%)
Query: 2027 LTGREHLYLYARLRGVPAEEIEKVANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAIALI 2086
+T +E + +YAR+ GV +I N + SL L +A L TYS GNKR+LSTAIAL+
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 2087 GCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSHSMEECEALCTRLAIMVKG 2146
G ++ LDEP+TGMDP ARR+LWN++ G+A+V+TSHSMEEC+ALCT LAIMV+G
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 2147 AFRCMGTIQHLKSKFGDGYIVTMKIKSPKDDLLPDLNPVEQFFQGNFPG 2195
F C+G+ QHLKSKFG+ YI+ +K+K+ +D L D + + FPG
Sbjct: 121 KFTCLGSPQHLKSKFGNIYILKVKVKT--EDKLEDF---KCYVATTFPG 164
Score = 100 bits (250), Expect = 1e-20
Identities = 54/145 (37%), Positives = 87/145 (60%), Gaps = 2/145 (1%)
Query: 1018 LTVAEHMLFYAQLKGKSQEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVAIAFV 1077
+T E M+ YA++ G S+ + L + L L S G +R+LS AIA +
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 1078 GDAKVVILDEPTSGVDPYSRRSIWDLLLKYR-SGRTIIMSTHHMDEADLLGDRIAIIAQG 1136
G + V+ LDEP++G+DP +RR +W+++ K R SG+ I+M++H M+E D L +AI+ QG
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 1137 RLYCSGTPLFLKNCFGTGLYLTLVR 1161
+ C G+P LK+ FG +Y+ V+
Sbjct: 121 KFTCLGSPQHLKSKFG-NIYILKVK 144
>gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo
sapiens]
Length = 718
Score = 91.3 bits (225), Expect = 1e-17
Identities = 76/238 (31%), Positives = 121/238 (50%), Gaps = 25/238 (10%)
Query: 940 PCGRPAVDRLN---ITFYENQITAFLGHNGAGKTTTLSILTGLLPPTSGTVLVGGRDIET 996
PC RP + L +T +I A +G +G GKTT S+L PT+G V++ GRD+ T
Sbjct: 465 PC-RPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRT 523
Query: 997 SLDAV---RQSLGMCPQHNILFHHLTVAEHMLFYAQLKGKSQEEAQLEMEAMLED----- 1048
LD Q +G Q +LF T+ E++ F +L+ +E EA +
Sbjct: 524 -LDPSWLRGQVVGFISQEPVLFG-TTIMENIRF-GKLEASDEEVYTAAREANAHEFITSF 580
Query: 1049 -TGLHHKRNEEAQDLSGGMQRKLSVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKY 1107
G + E LSGG +++L++A A + V+ILDE TS +D S R + + L +
Sbjct: 581 PEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRA 640
Query: 1108 RSGRTIIMSTHHMDEADLLGDR-IAIIAQGRLYCSGT--PLFLKNCFGTGLYLTLVRK 1162
+GRT+++ H + + + G I ++A GR++ +GT L K GLY L+R+
Sbjct: 641 SAGRTVLVIAHRL--STVRGAHCIVVMADGRVWEAGTHEELLKKG----GLYAELIRR 692
Score = 50.8 bits (120), Expect = 1e-05
Identities = 58/215 (26%), Positives = 94/215 (43%), Gaps = 28/215 (13%)
Query: 1964 PGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILT-NISEVH-QNMGYCPQFD 2021
PG+ L+G +G GKTT +L T+G + G+ + T + S + Q +G+ Q
Sbjct: 482 PGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQEP 541
Query: 2022 AI-----------DELLTGREHLYLYARLRGVPAEEIEKVANWSIKSL--GLTVYADCLA 2068
+ +L E +Y AR E A+ I S G
Sbjct: 542 VLFGTTIMENIRFGKLEASDEEVYTAAR---------EANAHEFITSFPEGYNTVVGERG 592
Query: 2069 GTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSH 2128
T SGG K++L+ A ALI P +++LDE T+ +D ++ R++ + GR V++ +H
Sbjct: 593 TTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVVQEAL-DRASAGRTVLVIAH 651
Query: 2129 SMEECE-ALCTRLAIMVKGAFRCMGTIQHLKSKFG 2162
+ A C + +M G GT + L K G
Sbjct: 652 RLSTVRGAHC--IVVMADGRVWEAGTHEELLKKGG 684
>gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo
sapiens]
Length = 812
Score = 90.5 bits (223), Expect = 2e-17
Identities = 72/241 (29%), Positives = 121/241 (50%), Gaps = 22/241 (9%)
Query: 920 REHPGWVPGVCVKNL----VKIFEPCGRPAV---DRLNITFYENQITAFLGHNGAGKTTT 972
R G P C NL V F PC RP V L+++ + AF+G +G GK+T+
Sbjct: 556 RSQEGKKPDTCEGNLEFREVSFFYPC-RPDVFILRGLSLSIERGKTVAFVGSSGCGKSTS 614
Query: 973 LSILTGLLPPTSGTVLVGGRDI-ETSLDAVRQSLGMCPQHNILFHHLTVAEHMLFYAQLK 1031
+ +L L P G VL G D E ++ +R + + PQ +LF+ ++AE++ + +
Sbjct: 615 VQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFN-CSIAENIAYGDNSR 673
Query: 1032 GKSQEEAQ-----LEMEAMLEDTGLHHKRNEEA----QDLSGGMQRKLSVAIAFVGDAKV 1082
+E + + + +E GL K N + LSGG +++L++A A + K+
Sbjct: 674 VVPLDEIKEAANAANIHSFIE--GLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKI 731
Query: 1083 VILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIAIIAQGRLYCSG 1142
++LDE TS +D S + + L K R+GRT ++ TH + A D I ++ G++ G
Sbjct: 732 LLLDEATSALDNDSEKVVQHALDKARTGRTCLVVTHRL-SAIQNADLIVVLHNGKIKEQG 790
Query: 1143 T 1143
T
Sbjct: 791 T 791
Score = 52.8 bits (125), Expect = 4e-06
Identities = 55/229 (24%), Positives = 101/229 (44%), Gaps = 12/229 (5%)
Query: 1938 LRLHELTKIYPGTSSPAVDR-LCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDA 1996
L E++ YP + R L + + G+ +G +G GK+T+ ++L G
Sbjct: 570 LEFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQV 629
Query: 1997 TVAGKSILT-NISEVHQNMGYCPQFDAIDELLTGREHLYLYARLRGVPAEEIEKVANWS- 2054
G N+ + + PQ + E++ R VP +EI++ AN +
Sbjct: 630 LFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIA-ENIAYGDNSRVVPLDEIKEAANAAN 688
Query: 2055 IKSL--GLTVYADCLAGT----YSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRM 2108
I S GL + G SGG K++L+ A AL+ P ++LLDE T+ +D + ++
Sbjct: 689 IHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKV 748
Query: 2109 LWNVIVSIIREGRAVVLTSHSMEECEALCTRLAIMVKGAFRCMGTIQHL 2157
+ + + R GR ++ +H + + + ++ G + GT Q L
Sbjct: 749 VQHAL-DKARTGRTCLVVTHRLSAIQN-ADLIVVLHNGKIKEQGTHQEL 795
Score = 51.2 bits (121), Expect = 1e-05
Identities = 50/196 (25%), Positives = 83/196 (42%), Gaps = 13/196 (6%)
Query: 1002 RQSLGMCPQHNILFHHLTVAEHMLFYAQLKGKSQEEAQLEMEAMLEDTGLHHKRN----- 1056
R +G+ Q +LF T + + Y + +E + EA D +
Sbjct: 16 RDHIGVVSQEPVLFG--TTISNNIKYGRDDVTDEEMERAAREANAYDFIMEFPNKFNTLV 73
Query: 1057 -EEAQDLSGGMQRKLSVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIM 1115
E+ +SGG ++++++A A V + K++ILDE TS +D S+ ++ L K GRT I+
Sbjct: 74 GEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAALEKASKGRTTIV 133
Query: 1116 STHHMDEADLLGDRIAIIAQGRLYCSGTPLFLKNCFGTGLYLTLVRKMKNIQSQRKGSEG 1175
H + D I + G L G L GLY +LV ++ +
Sbjct: 134 VAHRLSTI-RSADLIVTLKDGMLAEKGAHAEL--MAKRGLYYSLVMSQDIKKADEQMESM 190
Query: 1176 TCSCSSKGFSTTCPAH 1191
T S K + + P H
Sbjct: 191 TYSTERK--TNSLPLH 204
Score = 38.1 bits (87), Expect = 0.099
Identities = 25/106 (23%), Positives = 50/106 (47%), Gaps = 2/106 (1%)
Query: 2072 SGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSHSME 2131
SGG K++++ A AL+ P +++LDE T+ +D +++ + + +GR ++ +H +
Sbjct: 81 SGGQKQRIAIARALVRNPKILILDEATSALDSESKSAV-QAALEKASKGRTTIVVAHRLS 139
Query: 2132 ECEALCTRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKIKSPKDD 2177
+ + + G G L +K G Y + M K D
Sbjct: 140 TIRS-ADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQDIKKAD 184
>gi|46592978 ATP-binding cassette sub-family G member 1 isoform 7
[Homo sapiens]
Length = 663
Score = 90.1 bits (222), Expect = 2e-17
Identities = 63/194 (32%), Positives = 100/194 (51%), Gaps = 6/194 (3%)
Query: 953 FYENQITAFLGHNGAGKTTTLSILTGLLPP-TSGTVLVGGRDIETSLDAVRQSLGMCPQH 1011
F ++ A +G +GAGK+T ++IL G G VL+ G + L R+ Q
Sbjct: 105 FNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLING--LPRDLRCFRKVSCYIMQD 162
Query: 1012 NILFHHLTVAEHMLFYAQLKGKSQEEAQLEM-EAMLEDTGLHHKRNEEAQDLSGGMQRKL 1070
++L HLTV E M+ A LK + ++E + EM + +L GL N LSGG +++L
Sbjct: 163 DMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRL 222
Query: 1071 SVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADL--LGD 1128
++A+ V + V+ DEPTSG+D S + L+ G I+ T H A L L D
Sbjct: 223 AIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFD 282
Query: 1129 RIAIIAQGRLYCSG 1142
++ +++QG+ G
Sbjct: 283 QLYVLSQGQCVYRG 296
Score = 66.6 bits (161), Expect = 3e-10
Identities = 44/165 (26%), Positives = 85/165 (51%), Gaps = 2/165 (1%)
Query: 1965 GECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNISEVHQNMGYCPQFDAID 2024
GE ++G +GAGK+T +L G T V + ++ + Y Q D +
Sbjct: 108 GELVAIMGPSGAGKSTLMNILAGYRE-TGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLL 166
Query: 2025 ELLTGREHLYLYARLRGVPAEEIEK-VANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAI 2083
LT +E + + A L+ +E + + + +LGL A+ G+ SGG +++L+ A+
Sbjct: 167 PHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIAL 226
Query: 2084 ALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSH 2128
L+ PP++ DEPT+G+D + + +++ + + GR+++ T H
Sbjct: 227 ELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIH 271
>gi|46592971 ATP-binding cassette sub-family G member 1 isoform 6
[Homo sapiens]
Length = 644
Score = 90.1 bits (222), Expect = 2e-17
Identities = 63/194 (32%), Positives = 100/194 (51%), Gaps = 6/194 (3%)
Query: 953 FYENQITAFLGHNGAGKTTTLSILTGLLPP-TSGTVLVGGRDIETSLDAVRQSLGMCPQH 1011
F ++ A +G +GAGK+T ++IL G G VL+ G + L R+ Q
Sbjct: 86 FNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLING--LPRDLRCFRKVSCYIMQD 143
Query: 1012 NILFHHLTVAEHMLFYAQLKGKSQEEAQLEM-EAMLEDTGLHHKRNEEAQDLSGGMQRKL 1070
++L HLTV E M+ A LK + ++E + EM + +L GL N LSGG +++L
Sbjct: 144 DMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRL 203
Query: 1071 SVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADL--LGD 1128
++A+ V + V+ DEPTSG+D S + L+ G I+ T H A L L D
Sbjct: 204 AIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFD 263
Query: 1129 RIAIIAQGRLYCSG 1142
++ +++QG+ G
Sbjct: 264 QLYVLSQGQCVYRG 277
Score = 66.6 bits (161), Expect = 3e-10
Identities = 44/165 (26%), Positives = 85/165 (51%), Gaps = 2/165 (1%)
Query: 1965 GECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNISEVHQNMGYCPQFDAID 2024
GE ++G +GAGK+T +L G T V + ++ + Y Q D +
Sbjct: 89 GELVAIMGPSGAGKSTLMNILAGYRE-TGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLL 147
Query: 2025 ELLTGREHLYLYARLRGVPAEEIEK-VANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAI 2083
LT +E + + A L+ +E + + + +LGL A+ G+ SGG +++L+ A+
Sbjct: 148 PHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIAL 207
Query: 2084 ALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSH 2128
L+ PP++ DEPT+G+D + + +++ + + GR+++ T H
Sbjct: 208 ELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIH 252
>gi|46592964 ATP-binding cassette sub-family G member 1 isoform 5
[Homo sapiens]
Length = 668
Score = 90.1 bits (222), Expect = 2e-17
Identities = 63/194 (32%), Positives = 100/194 (51%), Gaps = 6/194 (3%)
Query: 953 FYENQITAFLGHNGAGKTTTLSILTGLLPP-TSGTVLVGGRDIETSLDAVRQSLGMCPQH 1011
F ++ A +G +GAGK+T ++IL G G VL+ G + L R+ Q
Sbjct: 110 FNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLING--LPRDLRCFRKVSCYIMQD 167
Query: 1012 NILFHHLTVAEHMLFYAQLKGKSQEEAQLEM-EAMLEDTGLHHKRNEEAQDLSGGMQRKL 1070
++L HLTV E M+ A LK + ++E + EM + +L GL N LSGG +++L
Sbjct: 168 DMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRL 227
Query: 1071 SVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADL--LGD 1128
++A+ V + V+ DEPTSG+D S + L+ G I+ T H A L L D
Sbjct: 228 AIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFD 287
Query: 1129 RIAIIAQGRLYCSG 1142
++ +++QG+ G
Sbjct: 288 QLYVLSQGQCVYRG 301
Score = 66.6 bits (161), Expect = 3e-10
Identities = 44/165 (26%), Positives = 85/165 (51%), Gaps = 2/165 (1%)
Query: 1965 GECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNISEVHQNMGYCPQFDAID 2024
GE ++G +GAGK+T +L G T V + ++ + Y Q D +
Sbjct: 113 GELVAIMGPSGAGKSTLMNILAGYRE-TGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLL 171
Query: 2025 ELLTGREHLYLYARLRGVPAEEIEK-VANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAI 2083
LT +E + + A L+ +E + + + +LGL A+ G+ SGG +++L+ A+
Sbjct: 172 PHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIAL 231
Query: 2084 ALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSH 2128
L+ PP++ DEPT+G+D + + +++ + + GR+++ T H
Sbjct: 232 ELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIH 276
>gi|46592956 ATP-binding cassette sub-family G member 1 isoform 3
[Homo sapiens]
Length = 677
Score = 90.1 bits (222), Expect = 2e-17
Identities = 63/194 (32%), Positives = 100/194 (51%), Gaps = 6/194 (3%)
Query: 953 FYENQITAFLGHNGAGKTTTLSILTGLLPP-TSGTVLVGGRDIETSLDAVRQSLGMCPQH 1011
F ++ A +G +GAGK+T ++IL G G VL+ G + L R+ Q
Sbjct: 119 FNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLING--LPRDLRCFRKVSCYIMQD 176
Query: 1012 NILFHHLTVAEHMLFYAQLKGKSQEEAQLEM-EAMLEDTGLHHKRNEEAQDLSGGMQRKL 1070
++L HLTV E M+ A LK + ++E + EM + +L GL N LSGG +++L
Sbjct: 177 DMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRL 236
Query: 1071 SVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADL--LGD 1128
++A+ V + V+ DEPTSG+D S + L+ G I+ T H A L L D
Sbjct: 237 AIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFD 296
Query: 1129 RIAIIAQGRLYCSG 1142
++ +++QG+ G
Sbjct: 297 QLYVLSQGQCVYRG 310
Score = 66.6 bits (161), Expect = 3e-10
Identities = 44/165 (26%), Positives = 85/165 (51%), Gaps = 2/165 (1%)
Query: 1965 GECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNISEVHQNMGYCPQFDAID 2024
GE ++G +GAGK+T +L G T V + ++ + Y Q D +
Sbjct: 122 GELVAIMGPSGAGKSTLMNILAGYRE-TGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLL 180
Query: 2025 ELLTGREHLYLYARLRGVPAEEIEK-VANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAI 2083
LT +E + + A L+ +E + + + +LGL A+ G+ SGG +++L+ A+
Sbjct: 181 PHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIAL 240
Query: 2084 ALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSH 2128
L+ PP++ DEPT+G+D + + +++ + + GR+++ T H
Sbjct: 241 ELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIH 285
>gi|46592915 ATP-binding cassette sub-family G member 1 isoform 4
[Homo sapiens]
Length = 678
Score = 90.1 bits (222), Expect = 2e-17
Identities = 63/194 (32%), Positives = 100/194 (51%), Gaps = 6/194 (3%)
Query: 953 FYENQITAFLGHNGAGKTTTLSILTGLLPP-TSGTVLVGGRDIETSLDAVRQSLGMCPQH 1011
F ++ A +G +GAGK+T ++IL G G VL+ G + L R+ Q
Sbjct: 108 FNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLING--LPRDLRCFRKVSCYIMQD 165
Query: 1012 NILFHHLTVAEHMLFYAQLKGKSQEEAQLEM-EAMLEDTGLHHKRNEEAQDLSGGMQRKL 1070
++L HLTV E M+ A LK + ++E + EM + +L GL N LSGG +++L
Sbjct: 166 DMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRL 225
Query: 1071 SVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADL--LGD 1128
++A+ V + V+ DEPTSG+D S + L+ G I+ T H A L L D
Sbjct: 226 AIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFD 285
Query: 1129 RIAIIAQGRLYCSG 1142
++ +++QG+ G
Sbjct: 286 QLYVLSQGQCVYRG 299
Score = 66.6 bits (161), Expect = 3e-10
Identities = 44/165 (26%), Positives = 85/165 (51%), Gaps = 2/165 (1%)
Query: 1965 GECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNISEVHQNMGYCPQFDAID 2024
GE ++G +GAGK+T +L G T V + ++ + Y Q D +
Sbjct: 111 GELVAIMGPSGAGKSTLMNILAGYRE-TGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLL 169
Query: 2025 ELLTGREHLYLYARLRGVPAEEIEK-VANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAI 2083
LT +E + + A L+ +E + + + +LGL A+ G+ SGG +++L+ A+
Sbjct: 170 PHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIAL 229
Query: 2084 ALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSH 2128
L+ PP++ DEPT+G+D + + +++ + + GR+++ T H
Sbjct: 230 ELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIH 274
>gi|46592898 ATP-binding cassette sub-family G member 1 isoform 2
[Homo sapiens]
Length = 666
Score = 90.1 bits (222), Expect = 2e-17
Identities = 63/194 (32%), Positives = 100/194 (51%), Gaps = 6/194 (3%)
Query: 953 FYENQITAFLGHNGAGKTTTLSILTGLLPP-TSGTVLVGGRDIETSLDAVRQSLGMCPQH 1011
F ++ A +G +GAGK+T ++IL G G VL+ G + L R+ Q
Sbjct: 108 FNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLING--LPRDLRCFRKVSCYIMQD 165
Query: 1012 NILFHHLTVAEHMLFYAQLKGKSQEEAQLEM-EAMLEDTGLHHKRNEEAQDLSGGMQRKL 1070
++L HLTV E M+ A LK + ++E + EM + +L GL N LSGG +++L
Sbjct: 166 DMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRL 225
Query: 1071 SVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADL--LGD 1128
++A+ V + V+ DEPTSG+D S + L+ G I+ T H A L L D
Sbjct: 226 AIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFD 285
Query: 1129 RIAIIAQGRLYCSG 1142
++ +++QG+ G
Sbjct: 286 QLYVLSQGQCVYRG 299
Score = 66.6 bits (161), Expect = 3e-10
Identities = 44/165 (26%), Positives = 85/165 (51%), Gaps = 2/165 (1%)
Query: 1965 GECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNISEVHQNMGYCPQFDAID 2024
GE ++G +GAGK+T +L G T V + ++ + Y Q D +
Sbjct: 111 GELVAIMGPSGAGKSTLMNILAGYRE-TGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLL 169
Query: 2025 ELLTGREHLYLYARLRGVPAEEIEK-VANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAI 2083
LT +E + + A L+ +E + + + +LGL A+ G+ SGG +++L+ A+
Sbjct: 170 PHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIAL 229
Query: 2084 ALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSH 2128
L+ PP++ DEPT+G+D + + +++ + + GR+++ T H
Sbjct: 230 ELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIH 274
>gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo
sapiens]
Length = 1464
Score = 87.4 bits (215), Expect = 1e-16
Identities = 123/456 (26%), Positives = 196/456 (42%), Gaps = 49/456 (10%)
Query: 732 ILFLFLLAFSTATIMLCFLLSTFFSKAS-----LAAACSGVIYFTLYLP--HILCFAWQD 784
IL F + A L F+L+ + A+ LA SG+ + L LP I+ + Q
Sbjct: 996 ILNRFSSDVACADDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLLPPLSIMYYHVQR 1055
Query: 785 RMTA---ELKKAVSL-LSP-------------VAFGFGTEYLVRFEEQGLGLQWSNIGNS 827
A EL++ SL LSP V G Y RFEE+ L L N
Sbjct: 1056 HYRASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATY--RFEEENLRLLELNQRCQ 1113
Query: 828 PTEGDEFSFLLSMQMMLLDAAVYGLLAWYLDQVFPGDYGTPLPWYFLLQESYWLGGEGCS 887
+L +++ L+ AAV +A + G P L SY L G
Sbjct: 1114 FATSATMQWL-DIRLQLMGAAVVSAIAGIA--LVQHQQGLANPGLVGLSLSYALSLTGLL 1170
Query: 888 -------TREERALEKTEPLTEETED-PEHPEGIHDSFFEREHPGWVP--GVCVKNLVKI 937
T+ E L E L E T D P+ P+G GW+ GV +++V
Sbjct: 1171 SGLVSSFTQTEAMLVSVERLEEYTCDLPQEPQGQPLQL----GTGWLTQGGVEFQDVVLA 1226
Query: 938 FEPCGRPAVDRLNITFYENQITAFLGHNGAGKTTTLSILTGLLPPTSGTVLVGGRDI-ET 996
+ P A+D + + +G G+GK++ L +L LL P+SG VL+ G D +
Sbjct: 1227 YRPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQL 1286
Query: 997 SLDAVRQSLGMCPQHNILFHHLTVAEHMLFYAQLKGKSQEEAQLEM---EAMLEDTGLHH 1053
L +R L + PQ LF TV E++ K ++ +A + E + GL
Sbjct: 1287 ELAQLRSQLAIIPQEPFLFSG-TVRENLDPQGLHKDRALWQALKQCHLSEVITSMGGLDG 1345
Query: 1054 KRNEEAQDLSGGMQRKLSVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTI 1113
+ E + LS G ++ L +A A + DAK++ +DE T+ VD + + + + K + +T+
Sbjct: 1346 ELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFANKTV 1405
Query: 1114 IMSTHHMDEADLLGDRIAIIAQGRLYCSGTPLFLKN 1149
+ H ++ L DR+ ++ GR+ +P L+N
Sbjct: 1406 LTIAHRLNTI-LNSDRVLVLQAGRVVELDSPATLRN 1440
Score = 48.1 bits (113), Expect = 1e-04
Identities = 45/195 (23%), Positives = 87/195 (44%), Gaps = 16/195 (8%)
Query: 955 ENQITAFLGHNGAGKTTTLSILTGLLPPTSGTVLVGGRDIETSLDAVRQSLGMCPQHNIL 1014
+ + +G G GK++ L+ + G L G V V G + + G+ Q +
Sbjct: 597 KGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRG---------LSKGFGLATQEPWI 647
Query: 1015 FHHLTVAEHMLFY----AQLKGKSQEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKL 1070
T+ +++LF AQL + E L + + G + E+ LSGG + ++
Sbjct: 648 -QFATIRDNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARI 706
Query: 1071 SVAIAFVGDAKVVILDEPTSGVD-PYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDR 1129
++A A + ++ +LD+P + VD + + +L S T ++ TH + + D
Sbjct: 707 ALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLLCTHRTEYLE-RADA 765
Query: 1130 IAIIAQGRLYCSGTP 1144
+ ++ GRL +G P
Sbjct: 766 VLLMEAGRLIRAGPP 780
Score = 33.5 bits (75), Expect = 2.4
Identities = 59/282 (20%), Positives = 117/282 (41%), Gaps = 27/282 (9%)
Query: 1845 LIDLALSQAVTDVYARFGEEHSANPFHWDLIGKNL-FAMVVEGVVYFLLTLLVQRHFFLS 1903
L+ A+ A+ + ++ ANP L+G +L +A+ + G++ L++ Q L
Sbjct: 1129 LMGAAVVSAIAGIALVQHQQGLANP---GLVGLSLSYALSLTGLLSGLVSSFTQTEAMLV 1185
Query: 1904 QWIAEPTKEPIVDEDDDVAEERQRIITGGNKTDILRLHELTKIYPGTSSPAVDRLCVGVR 1963
E +E D + + ++ TG + ++ Y A+D + V+
Sbjct: 1186 S--VERLEEYTCDLPQEPQGQPLQLGTGWLTQGGVEFQDVVLAYRPGLPNALDGVTFCVQ 1243
Query: 1964 PGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAG-KSILTNISEVHQNMGYCPQFDA 2022
PGE G++G G+GK++ +L +SG + G + ++++ + PQ
Sbjct: 1244 PGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQLAIIPQEPF 1303
Query: 2023 IDELLTGREHLYLYARLRGVPAEEIEKVANW-SIKSLGLTVYADCLAG----------TY 2071
+ T RE+L P + A W ++K L+ + G +
Sbjct: 1304 LFS-GTVRENL--------DPQGLHKDRALWQALKQCHLSEVITSMGGLDGELGEGGRSL 1354
Query: 2072 SGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVI 2113
S G ++ L A AL+ ++ +DE T +D + ++L I
Sbjct: 1355 SLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTI 1396
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 86.7 bits (213), Expect = 2e-16
Identities = 59/178 (33%), Positives = 97/178 (54%), Gaps = 7/178 (3%)
Query: 949 LNITFYENQITAFLGHNGAGKTTTLSILTGLLPPTSGTVLVGGRDIET-SLDAVRQSLGM 1007
LN+ Q A +G++G GK+TT+ ++ L PT G V V G+DI T ++ +R+ +G+
Sbjct: 413 LNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGV 472
Query: 1008 CPQHNILFHHLTVAEHMLFYAQLKGKSQ-EEAQLEMEAMLEDTGLHHKRN----EEAQDL 1062
Q +LF T+AE++ + + + E+A E A L HK + E L
Sbjct: 473 VSQEPVLFA-TTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQL 531
Query: 1063 SGGMQRKLSVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHM 1120
SGG ++++++A A V + K+++LDE TS +D S + L K R GRT I+ H +
Sbjct: 532 SGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRL 589
Score = 86.7 bits (213), Expect = 2e-16
Identities = 60/208 (28%), Positives = 107/208 (51%), Gaps = 10/208 (4%)
Query: 944 PAVDRLNITFYENQITAFLGHNGAGKTTTLSILTGLLPPTSGTVLVGGRDIET-SLDAVR 1002
P + L++ + Q A +G +G GK+T + +L P +G VL+ G++I+ ++ +R
Sbjct: 1051 PVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLR 1110
Query: 1003 QSLGMCPQHNILFHHLTVAEHMLFYAQLKGKSQEEA-----QLEMEAMLEDTGLHH--KR 1055
LG+ Q ILF ++AE++ + + SQEE + + A +E + K
Sbjct: 1111 AHLGIVSQEPILFD-CSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKV 1169
Query: 1056 NEEAQDLSGGMQRKLSVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIM 1115
++ LSGG ++++++A A V +++LDE TS +D S + + + L K R GRT I+
Sbjct: 1170 GDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIV 1229
Query: 1116 STHHMDEADLLGDRIAIIAQGRLYCSGT 1143
H + D I + GR+ GT
Sbjct: 1230 IAHRLSTIQ-NADLIVVFQNGRVKEHGT 1256
Score = 62.0 bits (149), Expect = 6e-09
Identities = 53/222 (23%), Positives = 101/222 (45%), Gaps = 19/222 (8%)
Query: 1953 PAVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILT-NISEVH 2011
P + L + V+ G+ L+G +G GK+T ++L +G + GK I N+ +
Sbjct: 1051 PVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLR 1110
Query: 2012 QNMGYCPQFDAIDELLTGREHLYLYARLRGVPAEEIEKVANWSIKSLGLTVYADCLAGTY 2071
++G Q + + E++ R V EEI + A K + + + L Y
Sbjct: 1111 AHLGIVSQEPILFDCSIA-ENIAYGDNSRVVSQEEIVRAA----KEANIHAFIESLPNKY 1165
Query: 2072 S-----------GGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREG 2120
S GG K++++ A AL+ P ++LLDE T+ +D ++ +++ + REG
Sbjct: 1166 STKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEAL-DKAREG 1224
Query: 2121 RAVVLTSHSMEECEALCTRLAIMVKGAFRCMGTIQHLKSKFG 2162
R ++ +H + + + + G + GT Q L ++ G
Sbjct: 1225 RTCIVIAHRLSTIQN-ADLIVVFQNGRVKEHGTHQQLLAQKG 1265
Score = 58.2 bits (139), Expect = 9e-08
Identities = 51/183 (27%), Positives = 90/183 (49%), Gaps = 24/183 (13%)
Query: 1962 VRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILT-NISEVHQNMGYCPQF 2020
V+ G+ L+G +G GK+TT +++ T G +V G+ I T N+ + + +G Q
Sbjct: 417 VQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQE 476
Query: 2021 DAI------DELLTGREHLYLYARLRGVPAEEIEKV---ANWSIKSLGLTVYADCLAGT- 2070
+ + + GRE+ V +EIEK AN + L D L G
Sbjct: 477 PVLFATTIAENIRYGREN---------VTMDEIEKAVKEANAYDFIMKLPHKFDTLVGER 527
Query: 2071 ---YSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTS 2127
SGG K++++ A AL+ P ++LLDE T+ +D ++ ++ V + R+GR ++ +
Sbjct: 528 GAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVV-QVALDKARKGRTTIVIA 586
Query: 2128 HSM 2130
H +
Sbjct: 587 HRL 589
>gi|215820660 ATP-binding cassette, subfamily G, member 4 [Homo
sapiens]
Length = 646
Score = 86.7 bits (213), Expect = 2e-16
Identities = 62/194 (31%), Positives = 98/194 (50%), Gaps = 6/194 (3%)
Query: 953 FYENQITAFLGHNGAGKTTTLSILTGLLPP-TSGTVLVGGRDIETSLDAVRQSLGMCPQH 1011
F ++ +G +GAGK+T ++IL G G +LV GR E L R+ Q
Sbjct: 92 FCRRELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRPRE--LRTFRKMSCYIMQD 149
Query: 1012 NILFHHLTVAEHMLFYAQLKGKSQEEAQLEMEA-MLEDTGLHHKRNEEAQDLSGGMQRKL 1070
++L HLTV E M+ A LK ++E + E+ +L GL + LSGG +++L
Sbjct: 150 DMLLPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCSHTRTALLSGGQRKRL 209
Query: 1071 SVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADL--LGD 1128
++A+ V + V+ DEPTSG+D S + L+ G I+ T H A L + D
Sbjct: 210 AIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIHQPSAKLFEMFD 269
Query: 1129 RIAIIAQGRLYCSG 1142
++ I++QG+ G
Sbjct: 270 KLYILSQGQCIFKG 283
Score = 67.0 bits (162), Expect = 2e-10
Identities = 45/165 (27%), Positives = 84/165 (50%), Gaps = 4/165 (2%)
Query: 1966 ECFGLLGVNGAGKTTTFKMLTG-DTTVTSGDATVAGKSILTNISEVHQNMGYCPQFDAID 2024
E G++G +GAGK+T +L G + G V G+ + + Y Q D +
Sbjct: 96 ELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRP--RELRTFRKMSCYIMQDDMLL 153
Query: 2025 ELLTGREHLYLYARLRGVPAEEIEK-VANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAI 2083
LT E + + A L+ +E++K + + +LGL + SGG +++L+ A+
Sbjct: 154 PHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCSHTRTALLSGGQRKRLAIAL 213
Query: 2084 ALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSH 2128
L+ PP++ DEPT+G+D + + +++ S+ + GR ++ T H
Sbjct: 214 ELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIH 258
>gi|20143975 ATP-binding cassette, subfamily G, member 4 [Homo
sapiens]
Length = 646
Score = 86.7 bits (213), Expect = 2e-16
Identities = 62/194 (31%), Positives = 98/194 (50%), Gaps = 6/194 (3%)
Query: 953 FYENQITAFLGHNGAGKTTTLSILTGLLPP-TSGTVLVGGRDIETSLDAVRQSLGMCPQH 1011
F ++ +G +GAGK+T ++IL G G +LV GR E L R+ Q
Sbjct: 92 FCRRELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRPRE--LRTFRKMSCYIMQD 149
Query: 1012 NILFHHLTVAEHMLFYAQLKGKSQEEAQLEMEA-MLEDTGLHHKRNEEAQDLSGGMQRKL 1070
++L HLTV E M+ A LK ++E + E+ +L GL + LSGG +++L
Sbjct: 150 DMLLPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCSHTRTALLSGGQRKRL 209
Query: 1071 SVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADL--LGD 1128
++A+ V + V+ DEPTSG+D S + L+ G I+ T H A L + D
Sbjct: 210 AIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIHQPSAKLFEMFD 269
Query: 1129 RIAIIAQGRLYCSG 1142
++ I++QG+ G
Sbjct: 270 KLYILSQGQCIFKG 283
Score = 67.0 bits (162), Expect = 2e-10
Identities = 45/165 (27%), Positives = 84/165 (50%), Gaps = 4/165 (2%)
Query: 1966 ECFGLLGVNGAGKTTTFKMLTG-DTTVTSGDATVAGKSILTNISEVHQNMGYCPQFDAID 2024
E G++G +GAGK+T +L G + G V G+ + + Y Q D +
Sbjct: 96 ELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRP--RELRTFRKMSCYIMQDDMLL 153
Query: 2025 ELLTGREHLYLYARLRGVPAEEIEK-VANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAI 2083
LT E + + A L+ +E++K + + +LGL + SGG +++L+ A+
Sbjct: 154 PHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCSHTRTALLSGGQRKRLAIAL 213
Query: 2084 ALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSH 2128
L+ PP++ DEPT+G+D + + +++ S+ + GR ++ T H
Sbjct: 214 ELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIH 258
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.138 0.424
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 89,651,023
Number of Sequences: 37866
Number of extensions: 4282290
Number of successful extensions: 13647
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 92
Number of HSP's successfully gapped in prelim test: 18
Number of HSP's that attempted gapping in prelim test: 12903
Number of HSP's gapped (non-prelim): 410
length of query: 2273
length of database: 18,247,518
effective HSP length: 118
effective length of query: 2155
effective length of database: 13,779,330
effective search space: 29694456150
effective search space used: 29694456150
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.