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Search of human proteins with 105990537
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|105990537 phosphodiesterase 6B isoform 1 [Homo sapiens]
(854 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|105990537 phosphodiesterase 6B isoform 1 [Homo sapiens] 1731 0.0
gi|223718037 phosphodiesterase 6B isoform 2 [Homo sapiens] 1725 0.0
gi|170650674 phosphodiesterase 6A [Homo sapiens] 1266 0.0
gi|223718019 phosphodiesterase 6B isoform 3 [Homo sapiens] 1171 0.0
gi|157364939 phosphodiesterase 6C [Homo sapiens] 1137 0.0
gi|116536085 phosphodiesterase 11A isoform 4 [Homo sapiens] 429 e-120
gi|61744435 phosphodiesterase 5A isoform 1 [Homo sapiens] 406 e-113
gi|61744432 phosphodiesterase 5A isoform 3 [Homo sapiens] 406 e-113
gi|61744430 phosphodiesterase 5A isoform 2 [Homo sapiens] 406 e-113
gi|116536087 phosphodiesterase 11A isoform 3 [Homo sapiens] 380 e-105
gi|116536089 phosphodiesterase 11A isoform 2 [Homo sapiens] 347 4e-95
gi|116536083 phosphodiesterase 11A isoform 1 [Homo sapiens] 326 5e-89
gi|226246591 phosphodiesterase 2A isoform 3 [Homo sapiens] 282 1e-75
gi|219802706 phosphodiesterase 2A isoform 2 [Homo sapiens] 282 1e-75
gi|4505657 phosphodiesterase 2A isoform 1 [Homo sapiens] 282 1e-75
gi|194595488 phosphodiesterase 10A isoform 1 [Homo sapiens] 232 1e-60
gi|5729972 phosphodiesterase 10A isoform 2 [Homo sapiens] 231 3e-60
gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens] 142 2e-33
gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens] 142 2e-33
gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens] 141 2e-33
gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens] 141 2e-33
gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens] 141 2e-33
gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens] 141 2e-33
gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens] 136 9e-32
gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens] 136 9e-32
gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens] 136 9e-32
gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens] 132 2e-30
gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens] 132 2e-30
gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens] 132 2e-30
gi|48762748 phosphodiesterase 9A isoform n [Homo sapiens] 132 2e-30
>gi|105990537 phosphodiesterase 6B isoform 1 [Homo sapiens]
Length = 854
Score = 1731 bits (4483), Expect = 0.0
Identities = 854/854 (100%), Positives = 854/854 (100%)
Query: 1 MSLSEEQARSFLDQNPDFARQYFGKKLSPENVAAACEDGCPPDCDSLRDLCQVEESTALL 60
MSLSEEQARSFLDQNPDFARQYFGKKLSPENVAAACEDGCPPDCDSLRDLCQVEESTALL
Sbjct: 1 MSLSEEQARSFLDQNPDFARQYFGKKLSPENVAAACEDGCPPDCDSLRDLCQVEESTALL 60
Query: 61 ELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQPDSVLE 120
ELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQPDSVLE
Sbjct: 61 ELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQPDSVLE 120
Query: 121 DCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLATPI 180
DCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLATPI
Sbjct: 121 DCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLATPI 180
Query: 181 MNGKDVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLKIYHLSYLHNCETRRGQVLL 240
MNGKDVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLKIYHLSYLHNCETRRGQVLL
Sbjct: 181 MNGKDVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLKIYHLSYLHNCETRRGQVLL 240
Query: 241 WSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVLMGESQPY 300
WSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVLMGESQPY
Sbjct: 241 WSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVLMGESQPY 300
Query: 301 SGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWALASGLPSYVAESGFICNIMNA 360
SGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWALASGLPSYVAESGFICNIMNA
Sbjct: 301 SGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWALASGLPSYVAESGFICNIMNA 360
Query: 361 SADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLMES 420
SADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLMES
Sbjct: 361 SADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLMES 420
Query: 421 LTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRARLGKEPADC 480
LTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRARLGKEPADC
Sbjct: 421 LTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRARLGKEPADC 480
Query: 481 DEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVL 540
DEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVL
Sbjct: 481 DEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVL 540
Query: 541 VRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDID 600
VRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDID
Sbjct: 541 VRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDID 600
Query: 601 HRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLM 660
HRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLM
Sbjct: 601 HRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLM 660
Query: 661 DIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLS 720
DIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLS
Sbjct: 661 DIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLS 720
Query: 721 AITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCT 780
AITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCT
Sbjct: 721 AITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCT 780
Query: 781 FVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKALEEKEEEERVAAKKVGTEIC 840
FVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKALEEKEEEERVAAKKVGTEIC
Sbjct: 781 FVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKALEEKEEEERVAAKKVGTEIC 840
Query: 841 NGGPAPKSSTCCIL 854
NGGPAPKSSTCCIL
Sbjct: 841 NGGPAPKSSTCCIL 854
>gi|223718037 phosphodiesterase 6B isoform 2 [Homo sapiens]
Length = 853
Score = 1725 bits (4467), Expect = 0.0
Identities = 853/854 (99%), Positives = 853/854 (99%), Gaps = 1/854 (0%)
Query: 1 MSLSEEQARSFLDQNPDFARQYFGKKLSPENVAAACEDGCPPDCDSLRDLCQVEESTALL 60
MSLSEEQARSFLDQNPDFARQYFGKKLSPENVAAACEDGCPPDCDSLRDLCQVEESTALL
Sbjct: 1 MSLSEEQARSFLDQNPDFARQYFGKKLSPENVAAACEDGCPPDCDSLRDLCQVEESTALL 60
Query: 61 ELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQPDSVLE 120
ELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQPDSVLE
Sbjct: 61 ELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQPDSVLE 120
Query: 121 DCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLATPI 180
DCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLATPI
Sbjct: 121 DCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLATPI 180
Query: 181 MNGKDVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLKIYHLSYLHNCETRRGQVLL 240
MNGKDVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLKIYHLSYLHNCETRRGQVLL
Sbjct: 181 MNGKDVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLKIYHLSYLHNCETRRGQVLL 240
Query: 241 WSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVLMGESQPY 300
WSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVLMGESQPY
Sbjct: 241 WSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVLMGESQPY 300
Query: 301 SGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWALASGLPSYVAESGFICNIMNA 360
SGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWALASGLPSYVAESGFICNIMNA
Sbjct: 301 SGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWALASGLPSYVAESGFICNIMNA 360
Query: 361 SADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLMES 420
SADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLMES
Sbjct: 361 SADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLMES 420
Query: 421 LTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRARLGKEPADC 480
LTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRARLGKEPADC
Sbjct: 421 LTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRARLGKEPADC 480
Query: 481 DEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVL 540
DEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVL
Sbjct: 481 DEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVL 540
Query: 541 VRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDID 600
VRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDID
Sbjct: 541 VRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDID 600
Query: 601 HRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLM 660
HRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLM
Sbjct: 601 HRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLM 660
Query: 661 DIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLS 720
DIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLS
Sbjct: 661 DIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLS 720
Query: 721 AITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCT 780
AITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCT
Sbjct: 721 AITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCT 780
Query: 781 FVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKALEEKEEEERVAAKKVGTEIC 840
FVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKALEEKEEEERVAAKK GTEIC
Sbjct: 781 FVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKALEEKEEEERVAAKK-GTEIC 839
Query: 841 NGGPAPKSSTCCIL 854
NGGPAPKSSTCCIL
Sbjct: 840 NGGPAPKSSTCCIL 853
>gi|170650674 phosphodiesterase 6A [Homo sapiens]
Length = 860
Score = 1266 bits (3277), Expect = 0.0
Identities = 617/859 (71%), Positives = 709/859 (82%), Gaps = 11/859 (1%)
Query: 3 LSEEQARSFLDQNPDFARQYFG----KKLSPENVAAACEDGCPPDCDSLRDLCQVEESTA 58
++ E+ FLD N FA+QY+ KL + + A D + +EES
Sbjct: 4 VTAEEVEKFLDSNIGFAKQYYNLHYRAKLISDLLGAK---EAAVDFSNYHSPSSMEESEI 60
Query: 59 LLELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQPDSV 118
+ +L++D QE++ E+ +F V+++LC LLQADR SLFMYR RNG+AELATRLF+V D+V
Sbjct: 61 IFDLLRDFQENLQTEKCIFNVMKKLCFLLQADRMSLFMYRTRNGIAELATRLFNVHKDAV 120
Query: 119 LEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLAT 178
LEDCLV PD EIVFPLD+G+VGHVA +KK+ NV + E HF F D LT+YKTKN+LA+
Sbjct: 121 LEDCLVMPDQEIVFPLDMGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKTKNILAS 180
Query: 179 PIMNGKDVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLKIYHLSYLHNCETRRGQV 238
PIMNGKDVVA+IMAVNK++G FT DE++ LKYLNFA L +K+YHLSYLHNCETRRGQ+
Sbjct: 181 PIMNGKDVVAIIMAVNKVDGSHFTKRDEEILLKYLNFANLIMKVYHLSYLHNCETRRGQI 240
Query: 239 LLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVLMGESQ 298
LLWS +KVFEELTDIERQFHKA YTVRA+LNC+RYSVGLLDMTK+KEFFDVW VLMGE
Sbjct: 241 LLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGEVP 300
Query: 299 PYSGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWALASGLPSYVAESGFICNIM 358
PYSGPRTPDGREI FYKVIDYILHGKE+IKVIP P DHWAL SGLP+YVA++G ICNIM
Sbjct: 301 PYSGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPAYVAQNGLICNIM 360
Query: 359 NASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLM 418
NA A++ F FQ+ LD+SGW+IKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDE DE LM
Sbjct: 361 NAPAEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEMDETLM 420
Query: 419 ESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRARLGKEPA 478
ESLTQFLGWSV+N DTY+ MNKLENRKDI QD+V YHVKCD +EIQ IL TR GKEP
Sbjct: 421 ESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCDNEEIQKILKTREVYGKEPW 480
Query: 479 DCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQE 538
+C+E+EL EIL+ ELP ++I +FHFSDL TEL+LVKCGIQMYYEL VV KF IPQE
Sbjct: 481 ECEEEELAEILQAELPDADKYEINKFHFSDLPLTELELVKCGIQMYYELKVVDKFHIPQE 540
Query: 539 VLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHD 598
LVRF++S+SKGYR+ITYHNWRHGFNV QTMF+LL+TGKLK Y+TDLEA AMVTA CHD
Sbjct: 541 ALVRFMYSLSKGYRKITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHD 600
Query: 599 IDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIH 658
IDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGK LL +E+LNI+QNLNRRQHEH IH
Sbjct: 601 IDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIH 660
Query: 659 LMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACD 718
+MDIAIIATDLALYFKKR MFQKIVD+SK Y+ ++ W +Y+ LE TRKEIVMAMMMTACD
Sbjct: 661 MMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTRKEIVMAMMMTACD 720
Query: 719 LSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFV 778
LSAITKPWEVQS+VALLVAAEFWEQGDLERTVL Q PIPMMDRNKA ELPKLQVGFIDFV
Sbjct: 721 LSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFV 780
Query: 779 CTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKALEEKEEEERVAAKKVGTE 838
CTFVYKEFSRFHEEI PM D + NNRKEWKALADEY+AK+K EEK+++++ A
Sbjct: 781 CTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEYDAKMKVQEEKKQKQQSAKSAAAGN 840
Query: 839 ICNGGPAP----KSSTCCI 853
G P+P S +CCI
Sbjct: 841 QPGGNPSPGGATTSKSCCI 859
>gi|223718019 phosphodiesterase 6B isoform 3 [Homo sapiens]
Length = 575
Score = 1171 bits (3029), Expect = 0.0
Identities = 575/575 (100%), Positives = 575/575 (100%)
Query: 280 MTKEKEFFDVWSVLMGESQPYSGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWA 339
MTKEKEFFDVWSVLMGESQPYSGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWA
Sbjct: 1 MTKEKEFFDVWSVLMGESQPYSGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWA 60
Query: 340 LASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVA 399
LASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVA
Sbjct: 61 LASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVA 120
Query: 400 TFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCD 459
TFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCD
Sbjct: 121 TFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCD 180
Query: 460 RDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKC 519
RDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKC
Sbjct: 181 RDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKC 240
Query: 520 GIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLK 579
GIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLK
Sbjct: 241 GIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLK 300
Query: 580 SYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSE 639
SYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSE
Sbjct: 301 SYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSE 360
Query: 640 ETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYL 699
ETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYL
Sbjct: 361 ETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYL 420
Query: 700 SLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMM 759
SLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMM
Sbjct: 421 SLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMM 480
Query: 760 DRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVK 819
DRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVK
Sbjct: 481 DRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVK 540
Query: 820 ALEEKEEEERVAAKKVGTEICNGGPAPKSSTCCIL 854
ALEEKEEEERVAAKKVGTEICNGGPAPKSSTCCIL
Sbjct: 541 ALEEKEEEERVAAKKVGTEICNGGPAPKSSTCCIL 575
>gi|157364939 phosphodiesterase 6C [Homo sapiens]
Length = 858
Score = 1137 bits (2940), Expect = 0.0
Identities = 551/856 (64%), Positives = 684/856 (79%), Gaps = 5/856 (0%)
Query: 3 LSEEQARSFLDQNPDFARQYFGKKLSPENVAAACEDGCPPDCDSLR--DLCQVEESTALL 60
+++ +L++NP FA++YF +KL E + ++ P S+ +L QVEES L
Sbjct: 4 INQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCL 63
Query: 61 ELVQDMQESINM-ERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQPDSVL 119
EL+ +QE E+ V + L+RL LLQADRCS+F+ R RNG+ E+A+RL V P S
Sbjct: 64 ELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKF 123
Query: 120 EDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLATP 179
ED LV PD E+VFPLDIG+VG A TKK NV DV + HFS F D+ T Y TKN+LATP
Sbjct: 124 EDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATP 183
Query: 180 IMNGKDVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLKIYHLSYLHNCETRRGQVL 239
I+ GK+V+AVIMAVNK+N F+ +DE+VF KYLNF ++ L+++H SY++N E+RR Q+L
Sbjct: 184 IVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQIL 243
Query: 240 LWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVLMGESQP 299
+WSANKVFEELTD+ERQFHKA YTVR+YLNCERYS+GLLDMTKEKEF+D W + +GE +P
Sbjct: 244 MWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEP 303
Query: 300 YSGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWALASGLPSYVAESGFICNIMN 359
Y GP+TPDGRE+ FYK+IDYILHGKEEIKVIPTP ADHW L SGLP+YVAE+GFICN+MN
Sbjct: 304 YKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMN 363
Query: 360 ASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLME 419
A ADE F FQ+G +D++GW+IKNVLS+PIVNKKE+IVGVATFYNRKDGKPFDE DE + E
Sbjct: 364 APADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITE 423
Query: 420 SLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRARLGKEPA- 478
+LTQFLGWS++NTDTYDKMNKLENRKDIAQ+M++ K +EI+ IL + +L +
Sbjct: 424 TLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVID 483
Query: 479 DCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQE 538
DC+E +L ILKE+LP P + ++YEF FSD TE L+KCGI++++E+ VV KF++P E
Sbjct: 484 DCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVE 543
Query: 539 VLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHD 598
VL R+++++ KGYR +TYHNWRHGFNV QTMFTLLMTG+LK YYTDLEAFAM+ A CHD
Sbjct: 544 VLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHD 603
Query: 599 IDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIH 658
IDHRGTNNLYQMKS +PLA+LHGSSILERHHLE+ K LL +E+LNI+QNLN+RQ E VIH
Sbjct: 604 IDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIH 663
Query: 659 LMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACD 718
L ++AIIATDLALYFKKR MFQKIVD + Q ++ ++Y++++ T+KEI+MAMMMTACD
Sbjct: 664 LFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACD 723
Query: 719 LSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFV 778
LSAITKPWEVQS+VAL+VA EFWEQGDLERTVL QQPIPMMDRNK ELPKLQVGFIDFV
Sbjct: 724 LSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFV 783
Query: 779 CTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKALEEKEEEERVAAKKVGTE 838
CTFVYKEFSRFH+EI PM LQNNR EWK+LADEY+AK+K +EE+ +++ A+K E
Sbjct: 784 CTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEK-AAE 842
Query: 839 ICNGGPAPKSSTCCIL 854
GG KS TC +L
Sbjct: 843 DSGGGDDKKSKTCLML 858
>gi|116536085 phosphodiesterase 11A isoform 4 [Homo sapiens]
Length = 933
Score = 429 bits (1102), Expect = e-120
Identities = 258/763 (33%), Positives = 402/763 (52%), Gaps = 62/763 (8%)
Query: 55 ESTALLELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYR-QRNGVAELATRLFSV 113
E LELV+D+ +++ + +K+L +C ++ ADRCSLF+ G L ++ F V
Sbjct: 201 ERQFFLELVKDISNDLDLTSLSYKILIFVCLMVDADRCSLFLVEGAAAGKKTLVSKFFDV 260
Query: 114 QPDSVLEDCLVPPDS-EIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKT 172
+ L C +S E+ P G++G+V + + VN+ D + F+ D+LT YKT
Sbjct: 261 HAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKLTGYKT 320
Query: 173 KNMLATPIMNGK-DVVAVIMAVNKL-NGPFFTSEDEDVFLKYLNFATLYLKIYHLSYLHN 230
K++L PI + +++ V A+NK+ G FT +DE V YL F + + L
Sbjct: 321 KSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASR 380
Query: 231 CETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVW 290
E R + LL N +FEE TD+E+ K + + L CER SV LL+ D+
Sbjct: 381 KEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLE--------DIE 432
Query: 291 SVLMGESQPYS--GPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWALASGLPSYV 348
S ++ ++ + P+ E F KE ++ S W + + + V
Sbjct: 433 SPVVKFTKSFELMSPKCSADAENSF----------KESME---KSSYSDWLINNSIAELV 479
Query: 349 AESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGK 408
A +G NI +A D F + + SG+ I++VL +PI N +I+GVA NR DGK
Sbjct: 480 ASTGLPVNISDAYQDPRFDAEADQI--SGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGK 537
Query: 409 PFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILP 468
PFD+ D+ L E+ F G + NT YD++ K ++ +A D++ YH C + E+
Sbjct: 538 PFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKA 597
Query: 469 TRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELG 528
L E A I + HF D ++ ++M+ ELG
Sbjct: 598 ANIPLVSELA----------------------IDDIHFDDFSLDVDAMITAALRMFMELG 635
Query: 529 VVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAF 588
+V+KF+I E L R+L ++ K YR + YHNWRH FNV Q MF +L T + T++E
Sbjct: 636 MVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEIL 695
Query: 589 AMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHG-SSILERHHLEFGKFLLSEETLNIYQN 647
A++ LCHD+DHRGTNN +Q KS + LA+L+G S+ LE HH +L E NI+ N
Sbjct: 696 AVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFAN 755
Query: 648 LNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKE 707
L+ +++ ++ L+ +I+ATDL LYF++R F ++V + EY ++
Sbjct: 756 LSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKG----------EYDWNIKNHRD 805
Query: 708 IVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAEL 767
I +M+MTACDL A+TKPWE+ +VA LV +EF+EQGD ER L P + DRN+ EL
Sbjct: 806 IFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDEL 865
Query: 768 PKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKAL 810
P+LQ+ +ID +C +Y+ + + ++ PM D + NR +W+ L
Sbjct: 866 PRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEEL 908
>gi|61744435 phosphodiesterase 5A isoform 1 [Homo sapiens]
Length = 875
Score = 406 bits (1044), Expect = e-113
Identities = 253/778 (32%), Positives = 418/778 (53%), Gaps = 79/778 (10%)
Query: 54 EESTALLELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAE-LATRLFS 112
++ + LLELV+D+ +++ + K+ + L+ ADR SLF+ + + + L +RLF
Sbjct: 147 DQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFD 206
Query: 113 VQPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKT 172
V S LE+ ++ I + G+VGHVA + +N++D E P F++ D++T YKT
Sbjct: 207 VAEGSTLEEV---SNNCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKT 263
Query: 173 KNMLATPIMNGKD-VVAVIMAVNKL--NGPFFTSEDEDVFLKYLNFATLYL---KIYHLS 226
+++L PI N ++ VV V A+NK NG FT +DE F YL F + L ++Y S
Sbjct: 264 QSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETS 323
Query: 227 YLHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEF 286
L N +R QVLL A+ +FEE +E K T+ +++ ++ ++ ++D F
Sbjct: 324 LLEN---KRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSF 380
Query: 287 FDVWSVLMGESQPYSGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWALASGLPS 346
V+ + E + S T + H +I +
Sbjct: 381 SSVFHMECEELEKSSDTLTRE--------------HDANKINYM-------------YAQ 413
Query: 347 YVAESGFICNIMNASADEMFKFQ-EGALDDSGWLIKNVLSMPIVN-KKEEIVGVATFYNR 404
YV + NI + S D+ F + E + + I+++L PI N KK +++GV N+
Sbjct: 414 YVKNTMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNK 473
Query: 405 KDG-----KPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCD 459
+ KPF+ DE +E+ F G + NT Y+ + + ++ + +++ YH
Sbjct: 474 MEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAA 533
Query: 460 RDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKC 519
+E + EL + +P T I +F FSD E ++L+ C
Sbjct: 534 EEETR-------------------ELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALC 574
Query: 520 GIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRR-ITYHNWRHGFNVAQTMFTLLMTGKL 578
I+M+ +L +V+ FQ+ EVL R++ S+ K YR+ + YHNWRH FN AQ MF L GK+
Sbjct: 575 TIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKI 634
Query: 579 KSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLS 638
++ TDLE A++ A L HD+DHRG NN Y +S++PLA+L+ SI+E HH + +L+
Sbjct: 635 QNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILN 694
Query: 639 EETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESK-NYQDKKSWVE 697
I L+ +++ + ++ AI+ATDLALY K+R F +++ +++ N +D
Sbjct: 695 SPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPH---- 750
Query: 698 YLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIP 757
+KE+ +AM+MTACDLSAITKPW +Q ++A LVA EF++QGD ER L+ +P
Sbjct: 751 -------QKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTD 803
Query: 758 MMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYE 815
+M+R K ++P +QVGFID +C +Y+ + E+ P+ D + NR++W+ALA++ E
Sbjct: 804 LMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQE 861
Score = 34.7 bits (78), Expect = 0.39
Identities = 29/153 (18%), Positives = 72/153 (47%), Gaps = 8/153 (5%)
Query: 50 LCQVEESTALLELVQDM-QESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELAT 108
L + + + LL+L + +E ++E ++ K+ + + +Q +C++F+ + ++ +
Sbjct: 324 LLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDE--DCSDSFS 381
Query: 109 RLFSVQPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHF---SSFAD 165
+F ++ + + + ++ +V T + +N+ DV++ F +
Sbjct: 382 SVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTG 441
Query: 166 ELTDYKTKNMLATPIMNGK--DVVAVIMAVNKL 196
+ +++L TPI NGK V+ V VNK+
Sbjct: 442 NVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKM 474
>gi|61744432 phosphodiesterase 5A isoform 3 [Homo sapiens]
Length = 823
Score = 406 bits (1044), Expect = e-113
Identities = 253/778 (32%), Positives = 418/778 (53%), Gaps = 79/778 (10%)
Query: 54 EESTALLELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAE-LATRLFS 112
++ + LLELV+D+ +++ + K+ + L+ ADR SLF+ + + + L +RLF
Sbjct: 95 DQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFD 154
Query: 113 VQPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKT 172
V S LE+ ++ I + G+VGHVA + +N++D E P F++ D++T YKT
Sbjct: 155 VAEGSTLEEV---SNNCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKT 211
Query: 173 KNMLATPIMNGKD-VVAVIMAVNKL--NGPFFTSEDEDVFLKYLNFATLYL---KIYHLS 226
+++L PI N ++ VV V A+NK NG FT +DE F YL F + L ++Y S
Sbjct: 212 QSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETS 271
Query: 227 YLHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEF 286
L N +R QVLL A+ +FEE +E K T+ +++ ++ ++ ++D F
Sbjct: 272 LLEN---KRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSF 328
Query: 287 FDVWSVLMGESQPYSGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWALASGLPS 346
V+ + E + S T + H +I +
Sbjct: 329 SSVFHMECEELEKSSDTLTRE--------------HDANKINYM-------------YAQ 361
Query: 347 YVAESGFICNIMNASADEMFKFQ-EGALDDSGWLIKNVLSMPIVN-KKEEIVGVATFYNR 404
YV + NI + S D+ F + E + + I+++L PI N KK +++GV N+
Sbjct: 362 YVKNTMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNK 421
Query: 405 KDG-----KPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCD 459
+ KPF+ DE +E+ F G + NT Y+ + + ++ + +++ YH
Sbjct: 422 MEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAA 481
Query: 460 RDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKC 519
+E + EL + +P T I +F FSD E ++L+ C
Sbjct: 482 EEETR-------------------ELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALC 522
Query: 520 GIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRR-ITYHNWRHGFNVAQTMFTLLMTGKL 578
I+M+ +L +V+ FQ+ EVL R++ S+ K YR+ + YHNWRH FN AQ MF L GK+
Sbjct: 523 TIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKI 582
Query: 579 KSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLS 638
++ TDLE A++ A L HD+DHRG NN Y +S++PLA+L+ SI+E HH + +L+
Sbjct: 583 QNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILN 642
Query: 639 EETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESK-NYQDKKSWVE 697
I L+ +++ + ++ AI+ATDLALY K+R F +++ +++ N +D
Sbjct: 643 SPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPH---- 698
Query: 698 YLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIP 757
+KE+ +AM+MTACDLSAITKPW +Q ++A LVA EF++QGD ER L+ +P
Sbjct: 699 -------QKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTD 751
Query: 758 MMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYE 815
+M+R K ++P +QVGFID +C +Y+ + E+ P+ D + NR++W+ALA++ E
Sbjct: 752 LMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQE 809
Score = 34.7 bits (78), Expect = 0.39
Identities = 29/153 (18%), Positives = 72/153 (47%), Gaps = 8/153 (5%)
Query: 50 LCQVEESTALLELVQDM-QESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELAT 108
L + + + LL+L + +E ++E ++ K+ + + +Q +C++F+ + ++ +
Sbjct: 272 LLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDE--DCSDSFS 329
Query: 109 RLFSVQPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHF---SSFAD 165
+F ++ + + + ++ +V T + +N+ DV++ F +
Sbjct: 330 SVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTG 389
Query: 166 ELTDYKTKNMLATPIMNGK--DVVAVIMAVNKL 196
+ +++L TPI NGK V+ V VNK+
Sbjct: 390 NVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKM 422
>gi|61744430 phosphodiesterase 5A isoform 2 [Homo sapiens]
Length = 833
Score = 406 bits (1044), Expect = e-113
Identities = 253/778 (32%), Positives = 418/778 (53%), Gaps = 79/778 (10%)
Query: 54 EESTALLELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAE-LATRLFS 112
++ + LLELV+D+ +++ + K+ + L+ ADR SLF+ + + + L +RLF
Sbjct: 105 DQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFD 164
Query: 113 VQPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKT 172
V S LE+ ++ I + G+VGHVA + +N++D E P F++ D++T YKT
Sbjct: 165 VAEGSTLEEV---SNNCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKT 221
Query: 173 KNMLATPIMNGKD-VVAVIMAVNKL--NGPFFTSEDEDVFLKYLNFATLYL---KIYHLS 226
+++L PI N ++ VV V A+NK NG FT +DE F YL F + L ++Y S
Sbjct: 222 QSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETS 281
Query: 227 YLHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEF 286
L N +R QVLL A+ +FEE +E K T+ +++ ++ ++ ++D F
Sbjct: 282 LLEN---KRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSF 338
Query: 287 FDVWSVLMGESQPYSGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWALASGLPS 346
V+ + E + S T + H +I +
Sbjct: 339 SSVFHMECEELEKSSDTLTRE--------------HDANKINYM-------------YAQ 371
Query: 347 YVAESGFICNIMNASADEMFKFQ-EGALDDSGWLIKNVLSMPIVN-KKEEIVGVATFYNR 404
YV + NI + S D+ F + E + + I+++L PI N KK +++GV N+
Sbjct: 372 YVKNTMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNK 431
Query: 405 KDG-----KPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCD 459
+ KPF+ DE +E+ F G + NT Y+ + + ++ + +++ YH
Sbjct: 432 MEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAA 491
Query: 460 RDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKC 519
+E + EL + +P T I +F FSD E ++L+ C
Sbjct: 492 EEETR-------------------ELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALC 532
Query: 520 GIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRR-ITYHNWRHGFNVAQTMFTLLMTGKL 578
I+M+ +L +V+ FQ+ EVL R++ S+ K YR+ + YHNWRH FN AQ MF L GK+
Sbjct: 533 TIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKI 592
Query: 579 KSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLS 638
++ TDLE A++ A L HD+DHRG NN Y +S++PLA+L+ SI+E HH + +L+
Sbjct: 593 QNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILN 652
Query: 639 EETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESK-NYQDKKSWVE 697
I L+ +++ + ++ AI+ATDLALY K+R F +++ +++ N +D
Sbjct: 653 SPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPH---- 708
Query: 698 YLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIP 757
+KE+ +AM+MTACDLSAITKPW +Q ++A LVA EF++QGD ER L+ +P
Sbjct: 709 -------QKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTD 761
Query: 758 MMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYE 815
+M+R K ++P +QVGFID +C +Y+ + E+ P+ D + NR++W+ALA++ E
Sbjct: 762 LMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQE 819
Score = 34.7 bits (78), Expect = 0.39
Identities = 29/153 (18%), Positives = 72/153 (47%), Gaps = 8/153 (5%)
Query: 50 LCQVEESTALLELVQDM-QESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELAT 108
L + + + LL+L + +E ++E ++ K+ + + +Q +C++F+ + ++ +
Sbjct: 282 LLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDE--DCSDSFS 339
Query: 109 RLFSVQPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHF---SSFAD 165
+F ++ + + + ++ +V T + +N+ DV++ F +
Sbjct: 340 SVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTG 399
Query: 166 ELTDYKTKNMLATPIMNGK--DVVAVIMAVNKL 196
+ +++L TPI NGK V+ V VNK+
Sbjct: 400 NVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKM 432
>gi|116536087 phosphodiesterase 11A isoform 3 [Homo sapiens]
Length = 683
Score = 380 bits (977), Expect = e-105
Identities = 227/656 (34%), Positives = 347/656 (52%), Gaps = 60/656 (9%)
Query: 160 FSSFADELTDYKTKNMLATPIMNGK-DVVAVIMAVNKL-NGPFFTSEDEDVFLKYLNFAT 217
F+ D+LT YKTK++L PI + +++ V A+NK+ G FT +DE V YL F
Sbjct: 58 FNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCG 117
Query: 218 LYLKIYHLSYLHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGL 277
+ + L E R + LL N +FEE TD+E+ K + + L CER SV L
Sbjct: 118 IAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLL 177
Query: 278 LDMTKEKEFFDVWSVLMGESQPYS--GPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSA 335
L+ D+ S ++ ++ + P+ E F KE ++ S
Sbjct: 178 LE--------DIESPVVKFTKSFELMSPKCSADAENSF----------KESME---KSSY 216
Query: 336 DHWALASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEI 395
W + + + VA +G NI +A D F + + SG+ I++VL +PI N +I
Sbjct: 217 SDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQI--SGFHIRSVLCVPIWNSNHQI 274
Query: 396 VGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYH 455
+GVA NR DGKPFD+ D+ L E+ F G + NT YD++ K ++ +A D++ YH
Sbjct: 275 IGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYH 334
Query: 456 VKCDRDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELD 515
C + E+ L E A I + HF D
Sbjct: 335 ATCSKAEVDKFKAANIPLVSELA----------------------IDDIHFDDFSLDVDA 372
Query: 516 LVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMT 575
++ ++M+ ELG+V+KF+I E L R+L ++ K YR + YHNWRH FNV Q MF +L T
Sbjct: 373 MITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTT 432
Query: 576 GKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHG-SSILERHHLEFGK 634
+ T++E A++ LCHD+DHRGTNN +Q KS + LA+L+G S+ LE HH
Sbjct: 433 AGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAV 492
Query: 635 FLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKS 694
+L E NI+ NL+ +++ ++ L+ +I+ATDL LYF++R F ++V +
Sbjct: 493 MILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKG-------- 544
Query: 695 WVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQ 754
EY ++I +M+MTACDL A+TKPWE+ +VA LV +EF+EQGD ER L
Sbjct: 545 --EYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLT 602
Query: 755 PIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKAL 810
P + DRN+ ELP+LQ+ +ID +C +Y+ + + ++ PM D + NR +W+ L
Sbjct: 603 PSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEEL 658
Score = 72.0 bits (175), Expect = 2e-12
Identities = 46/175 (26%), Positives = 86/175 (49%), Gaps = 8/175 (4%)
Query: 52 QVEESTALLELVQDM-QESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRL 110
+ E S ALLE+V D+ +E ++E++V K++ R TLL+ +RCS+ + T+
Sbjct: 132 EYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFTKS 191
Query: 111 FSVQPDSVLEDC------LVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFA 164
F + D + S + ++ + VA T VN+ D + P F + A
Sbjct: 192 FELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEA 251
Query: 165 DELTDYKTKNMLATPIMNGK-DVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATL 218
D+++ + +++L PI N ++ V +N+L+G F D+ +F ++ F L
Sbjct: 252 DQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGL 306
>gi|116536089 phosphodiesterase 11A isoform 2 [Homo sapiens]
Length = 575
Score = 347 bits (889), Expect = 4e-95
Identities = 206/602 (34%), Positives = 315/602 (52%), Gaps = 58/602 (9%)
Query: 212 YLNFATLYLKIYHLSYLHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCE 271
YL F + + L E R + LL N +FEE TD+E+ K + + L CE
Sbjct: 4 YLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCE 63
Query: 272 RYSVGLLDMTKEKEFFDVWSVLMGESQPYS--GPRTPDGREIVFYKVIDYILHGKEEIKV 329
R SV LL+ D+ S ++ ++ + P+ E F KE ++
Sbjct: 64 RCSVLLLE--------DIESPVVKFTKSFELMSPKCSADAENSF----------KESME- 104
Query: 330 IPTPSADHWALASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIV 389
S W + + + VA +G NI +A D F + + SG+ I++VL +PI
Sbjct: 105 --KSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQI--SGFHIRSVLCVPIW 160
Query: 390 NKKEEIVGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQ 449
N +I+GVA NR DGKPFD+ D+ L E+ F G + NT YD++ K ++ +A
Sbjct: 161 NSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVAL 220
Query: 450 DMVLYHVKCDRDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDL 509
D++ YH C + E+ L E A I + HF D
Sbjct: 221 DVLSYHATCSKAEVDKFKAANIPLVSELA----------------------IDDIHFDDF 258
Query: 510 ECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTM 569
++ ++M+ ELG+V+KF+I E L R+L ++ K YR + YHNWRH FNV Q M
Sbjct: 259 SLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLM 318
Query: 570 FTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHG-SSILERH 628
F +L T + T++E A++ LCHD+DHRGTNN +Q KS + LA+L+G S+ LE H
Sbjct: 319 FAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHH 378
Query: 629 HLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKN 688
H +L E NI+ NL+ +++ ++ L+ +I+ATDL LYF++R F ++V +
Sbjct: 379 HFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKG-- 436
Query: 689 YQDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLER 748
EY ++I +M+MTACDL A+TKPWE+ +VA LV +EF+EQGD ER
Sbjct: 437 --------EYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRER 488
Query: 749 TVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWK 808
L P + DRN+ ELP+LQ+ +ID +C +Y+ + + ++ PM D + NR +W+
Sbjct: 489 LELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWE 548
Query: 809 AL 810
L
Sbjct: 549 EL 550
Score = 72.0 bits (175), Expect = 2e-12
Identities = 46/175 (26%), Positives = 86/175 (49%), Gaps = 8/175 (4%)
Query: 52 QVEESTALLELVQDM-QESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRL 110
+ E S ALLE+V D+ +E ++E++V K++ R TLL+ +RCS+ + T+
Sbjct: 24 EYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFTKS 83
Query: 111 FSVQPDSVLEDC------LVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFA 164
F + D + S + ++ + VA T VN+ D + P F + A
Sbjct: 84 FELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEA 143
Query: 165 DELTDYKTKNMLATPIMNGK-DVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATL 218
D+++ + +++L PI N ++ V +N+L+G F D+ +F ++ F L
Sbjct: 144 DQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGL 198
>gi|116536083 phosphodiesterase 11A isoform 1 [Homo sapiens]
Length = 489
Score = 326 bits (836), Expect = 5e-89
Identities = 175/478 (36%), Positives = 266/478 (55%), Gaps = 35/478 (7%)
Query: 334 SADHWALASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKE 393
S W + + + VA +G NI +A D F + + SG+ I++VL +PI N
Sbjct: 21 SYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQI--SGFHIRSVLCVPIWNSNH 78
Query: 394 EIVGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVL 453
+I+GVA NR DGKPFD+ D+ L E+ F G + NT YD++ K ++ +A D++
Sbjct: 79 QIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLS 138
Query: 454 YHVKCDRDEIQLILPTRARLGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTE 513
YH C + E+ L E A I + HF D
Sbjct: 139 YHATCSKAEVDKFKAANIPLVSELA----------------------IDDIHFDDFSLDV 176
Query: 514 LDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLL 573
++ ++M+ ELG+V+KF+I E L R+L ++ K YR + YHNWRH FNV Q MF +L
Sbjct: 177 DAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAML 236
Query: 574 MTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHG-SSILERHHLEF 632
T + T++E A++ LCHD+DHRGTNN +Q KS + LA+L+G S+ LE HH
Sbjct: 237 TTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNH 296
Query: 633 GKFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDK 692
+L E NI+ NL+ +++ ++ L+ +I+ATDL LYF++R F ++V +
Sbjct: 297 AVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKG------ 350
Query: 693 KSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLD 752
EY ++I +M+MTACDL A+TKPWE+ +VA LV +EF+EQGD ER L
Sbjct: 351 ----EYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELK 406
Query: 753 QQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKAL 810
P + DRN+ ELP+LQ+ +ID +C +Y+ + + ++ PM D + NR +W+ L
Sbjct: 407 LTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEEL 464
Score = 45.8 bits (107), Expect = 2e-04
Identities = 23/78 (29%), Positives = 42/78 (53%), Gaps = 1/78 (1%)
Query: 142 VAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLATPIMNGK-DVVAVIMAVNKLNGPF 200
VA T VN+ D + P F + AD+++ + +++L PI N ++ V +N+L+G
Sbjct: 35 VASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKP 94
Query: 201 FTSEDEDVFLKYLNFATL 218
F D+ +F ++ F L
Sbjct: 95 FDDADQRLFEAFVIFCGL 112
>gi|226246591 phosphodiesterase 2A isoform 3 [Homo sapiens]
Length = 932
Score = 282 bits (721), Expect = 1e-75
Identities = 208/764 (27%), Positives = 360/764 (47%), Gaps = 99/764 (12%)
Query: 59 LLELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQPDSV 118
+L+L ++ + ++ + KVL+ L +A RC L + + N +L+ ++ D V
Sbjct: 221 ILQLCGELYD-LDASSLQLKVLQYLQQETRASRCCLLLVSEDN--LQLSCKVIG---DKV 274
Query: 119 LEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLAT 178
L + E+ FPL G +G V + KK + ++D+ + + + ML
Sbjct: 275 LGE-------EVSFPLT-GCLGQVVEDKKSIQLKDLTS--EDVQQLQSMLGCELQAMLCV 324
Query: 179 PIMNGK--DVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLK---IYHLSYLHNCET 233
P+++ VVA+ A NKL G FT EDE V ++ + L + CE
Sbjct: 325 PVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCEC 384
Query: 234 RRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVL 293
Q LL A +F L D+ + R N E SV LLD +
Sbjct: 385 ---QALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNE----------- 430
Query: 294 MGESQPYSGPRTPDGREIVFYKVIDYILHGKEEIKV-IPTPSADHWALASGLPSYVAESG 352
+ KV D + E ++ IP G+ +VA +G
Sbjct: 431 ------------------LVAKVFDGGVVDDESYEIRIPADQ--------GIAGHVATTG 464
Query: 353 FICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDE 412
I NI +A A +F G D +G+ +N+L PI N+ +E++GVA N+ +G F +
Sbjct: 465 QILNIPDAYAHPLF--YRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSK 522
Query: 413 QDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRAR 472
DE L + + + G S+ ++ Y K+N+ + R +A +M++YH+K DE +L
Sbjct: 523 FDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHD--- 579
Query: 473 LGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRK 532
G +P + F ++ E D + M ++ +
Sbjct: 580 -GIQPVAAIDSNFAS----------------FTYTPRSLPEDDTSMAILSMLQDMNFINN 622
Query: 533 FQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVT 592
++I L RF + KGYR YHNW H F+V+ + L +L +Y D+E FA+
Sbjct: 623 YKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFI 682
Query: 593 AGLCHDIDHRGTNNLYQMKSQNPLAKLHGS--SILERHHLEFGKFLLSEETLNIYQNLNR 650
+ +CHD+DHRGTNN +Q+ S++ LA L+ S S++ERHH +L+ NI+ + +R
Sbjct: 683 SCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSR 742
Query: 651 RQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVM 710
+ ++ ++ LM I+ATDLA + + QK+ + + +K+ +++
Sbjct: 743 KDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQ-----------HHRLLL 791
Query: 711 AMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKL 770
++MT+CDLS TK W+ K+A L+ EF+ QGDLE+ + +P+ MMDR K A +P+L
Sbjct: 792 CLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEK-AMGNRPMEMMDREK-AYIPEL 849
Query: 771 QVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEY 814
Q+ F++ + +YK + +++R+ +NR+ W ++ ++
Sbjct: 850 QISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKF 893
Score = 77.4 bits (189), Expect = 5e-14
Identities = 65/255 (25%), Positives = 120/255 (47%), Gaps = 29/255 (11%)
Query: 55 ESTALLELVQDMQESINMERVVFK-VLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSV 113
E ALL++ +++ ++ V+ + ++ L A+ CS+F+ Q EL ++F
Sbjct: 383 ECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQN----ELVAKVFD- 437
Query: 114 QPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTK 173
V++D EI P D G+ GHVA T +++N+ D P F D+ T ++T+
Sbjct: 438 --GGVVDD----ESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTR 491
Query: 174 NMLATPIMN-GKDVVAVIMAVNKLNGPFFTSEDEDVFLKY-------LNFATLYLKIYHL 225
N+L PI N ++V+ V VNK+NGP+F+ DED+ + + + LY K+
Sbjct: 492 NILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEA 551
Query: 226 SYLHNCETRRGQVLLWSANKVFEEL--------TDIERQFHKAFYTVRAYLNCERYSVGL 277
Y + + ++ + +L I+ F YT R+ L + S+ +
Sbjct: 552 QYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRS-LPEDDTSMAI 610
Query: 278 LDMTKEKEFFDVWSV 292
L M ++ F + + +
Sbjct: 611 LSMLQDMNFINNYKI 625
>gi|219802706 phosphodiesterase 2A isoform 2 [Homo sapiens]
Length = 934
Score = 282 bits (721), Expect = 1e-75
Identities = 208/764 (27%), Positives = 360/764 (47%), Gaps = 99/764 (12%)
Query: 59 LLELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQPDSV 118
+L+L ++ + ++ + KVL+ L +A RC L + + N +L+ ++ D V
Sbjct: 223 ILQLCGELYD-LDASSLQLKVLQYLQQETRASRCCLLLVSEDN--LQLSCKVIG---DKV 276
Query: 119 LEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLAT 178
L + E+ FPL G +G V + KK + ++D+ + + + ML
Sbjct: 277 LGE-------EVSFPLT-GCLGQVVEDKKSIQLKDLTS--EDVQQLQSMLGCELQAMLCV 326
Query: 179 PIMNGK--DVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLK---IYHLSYLHNCET 233
P+++ VVA+ A NKL G FT EDE V ++ + L + CE
Sbjct: 327 PVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCEC 386
Query: 234 RRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVL 293
Q LL A +F L D+ + R N E SV LLD +
Sbjct: 387 ---QALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNE----------- 432
Query: 294 MGESQPYSGPRTPDGREIVFYKVIDYILHGKEEIKV-IPTPSADHWALASGLPSYVAESG 352
+ KV D + E ++ IP G+ +VA +G
Sbjct: 433 ------------------LVAKVFDGGVVDDESYEIRIPADQ--------GIAGHVATTG 466
Query: 353 FICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDE 412
I NI +A A +F G D +G+ +N+L PI N+ +E++GVA N+ +G F +
Sbjct: 467 QILNIPDAYAHPLF--YRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSK 524
Query: 413 QDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRAR 472
DE L + + + G S+ ++ Y K+N+ + R +A +M++YH+K DE +L
Sbjct: 525 FDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHD--- 581
Query: 473 LGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRK 532
G +P + F ++ E D + M ++ +
Sbjct: 582 -GIQPVAAIDSNFAS----------------FTYTPRSLPEDDTSMAILSMLQDMNFINN 624
Query: 533 FQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVT 592
++I L RF + KGYR YHNW H F+V+ + L +L +Y D+E FA+
Sbjct: 625 YKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFI 684
Query: 593 AGLCHDIDHRGTNNLYQMKSQNPLAKLHGS--SILERHHLEFGKFLLSEETLNIYQNLNR 650
+ +CHD+DHRGTNN +Q+ S++ LA L+ S S++ERHH +L+ NI+ + +R
Sbjct: 685 SCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSR 744
Query: 651 RQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVM 710
+ ++ ++ LM I+ATDLA + + QK+ + + +K+ +++
Sbjct: 745 KDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQ-----------HHRLLL 793
Query: 711 AMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKL 770
++MT+CDLS TK W+ K+A L+ EF+ QGDLE+ + +P+ MMDR K A +P+L
Sbjct: 794 CLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEK-AMGNRPMEMMDREK-AYIPEL 851
Query: 771 QVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEY 814
Q+ F++ + +YK + +++R+ +NR+ W ++ ++
Sbjct: 852 QISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKF 895
Score = 77.4 bits (189), Expect = 5e-14
Identities = 65/255 (25%), Positives = 120/255 (47%), Gaps = 29/255 (11%)
Query: 55 ESTALLELVQDMQESINMERVVFK-VLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSV 113
E ALL++ +++ ++ V+ + ++ L A+ CS+F+ Q EL ++F
Sbjct: 385 ECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQN----ELVAKVFD- 439
Query: 114 QPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTK 173
V++D EI P D G+ GHVA T +++N+ D P F D+ T ++T+
Sbjct: 440 --GGVVDD----ESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTR 493
Query: 174 NMLATPIMN-GKDVVAVIMAVNKLNGPFFTSEDEDVFLKY-------LNFATLYLKIYHL 225
N+L PI N ++V+ V VNK+NGP+F+ DED+ + + + LY K+
Sbjct: 494 NILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEA 553
Query: 226 SYLHNCETRRGQVLLWSANKVFEEL--------TDIERQFHKAFYTVRAYLNCERYSVGL 277
Y + + ++ + +L I+ F YT R+ L + S+ +
Sbjct: 554 QYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRS-LPEDDTSMAI 612
Query: 278 LDMTKEKEFFDVWSV 292
L M ++ F + + +
Sbjct: 613 LSMLQDMNFINNYKI 627
>gi|4505657 phosphodiesterase 2A isoform 1 [Homo sapiens]
Length = 941
Score = 282 bits (721), Expect = 1e-75
Identities = 208/764 (27%), Positives = 360/764 (47%), Gaps = 99/764 (12%)
Query: 59 LLELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQPDSV 118
+L+L ++ + ++ + KVL+ L +A RC L + + N +L+ ++ D V
Sbjct: 230 ILQLCGELYD-LDASSLQLKVLQYLQQETRASRCCLLLVSEDN--LQLSCKVIG---DKV 283
Query: 119 LEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLAT 178
L + E+ FPL G +G V + KK + ++D+ + + + ML
Sbjct: 284 LGE-------EVSFPLT-GCLGQVVEDKKSIQLKDLTS--EDVQQLQSMLGCELQAMLCV 333
Query: 179 PIMNGK--DVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLK---IYHLSYLHNCET 233
P+++ VVA+ A NKL G FT EDE V ++ + L + CE
Sbjct: 334 PVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCEC 393
Query: 234 RRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVL 293
Q LL A +F L D+ + R N E SV LLD +
Sbjct: 394 ---QALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNE----------- 439
Query: 294 MGESQPYSGPRTPDGREIVFYKVIDYILHGKEEIKV-IPTPSADHWALASGLPSYVAESG 352
+ KV D + E ++ IP G+ +VA +G
Sbjct: 440 ------------------LVAKVFDGGVVDDESYEIRIPADQ--------GIAGHVATTG 473
Query: 353 FICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDE 412
I NI +A A +F G D +G+ +N+L PI N+ +E++GVA N+ +G F +
Sbjct: 474 QILNIPDAYAHPLF--YRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSK 531
Query: 413 QDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRAR 472
DE L + + + G S+ ++ Y K+N+ + R +A +M++YH+K DE +L
Sbjct: 532 FDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHD--- 588
Query: 473 LGKEPADCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRK 532
G +P + F ++ E D + M ++ +
Sbjct: 589 -GIQPVAAIDSNFAS----------------FTYTPRSLPEDDTSMAILSMLQDMNFINN 631
Query: 533 FQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVT 592
++I L RF + KGYR YHNW H F+V+ + L +L +Y D+E FA+
Sbjct: 632 YKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFI 691
Query: 593 AGLCHDIDHRGTNNLYQMKSQNPLAKLHGS--SILERHHLEFGKFLLSEETLNIYQNLNR 650
+ +CHD+DHRGTNN +Q+ S++ LA L+ S S++ERHH +L+ NI+ + +R
Sbjct: 692 SCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSR 751
Query: 651 RQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVM 710
+ ++ ++ LM I+ATDLA + + QK+ + + +K+ +++
Sbjct: 752 KDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQ-----------HHRLLL 800
Query: 711 AMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKL 770
++MT+CDLS TK W+ K+A L+ EF+ QGDLE+ + +P+ MMDR K A +P+L
Sbjct: 801 CLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEK-AMGNRPMEMMDREK-AYIPEL 858
Query: 771 QVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEY 814
Q+ F++ + +YK + +++R+ +NR+ W ++ ++
Sbjct: 859 QISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKF 902
Score = 77.4 bits (189), Expect = 5e-14
Identities = 65/255 (25%), Positives = 120/255 (47%), Gaps = 29/255 (11%)
Query: 55 ESTALLELVQDMQESINMERVVFK-VLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSV 113
E ALL++ +++ ++ V+ + ++ L A+ CS+F+ Q EL ++F
Sbjct: 392 ECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQN----ELVAKVFD- 446
Query: 114 QPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTK 173
V++D EI P D G+ GHVA T +++N+ D P F D+ T ++T+
Sbjct: 447 --GGVVDD----ESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTR 500
Query: 174 NMLATPIMN-GKDVVAVIMAVNKLNGPFFTSEDEDVFLKY-------LNFATLYLKIYHL 225
N+L PI N ++V+ V VNK+NGP+F+ DED+ + + + LY K+
Sbjct: 501 NILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEA 560
Query: 226 SYLHNCETRRGQVLLWSANKVFEEL--------TDIERQFHKAFYTVRAYLNCERYSVGL 277
Y + + ++ + +L I+ F YT R+ L + S+ +
Sbjct: 561 QYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRS-LPEDDTSMAI 619
Query: 278 LDMTKEKEFFDVWSV 292
L M ++ F + + +
Sbjct: 620 LSMLQDMNFINNYKI 634
>gi|194595488 phosphodiesterase 10A isoform 1 [Homo sapiens]
Length = 789
Score = 232 bits (592), Expect = 1e-60
Identities = 211/833 (25%), Positives = 372/833 (44%), Gaps = 118/833 (14%)
Query: 2 SLSEEQARSFLDQNPDFARQYFGKKLSPENVAAACEDGCPPDCDSLRDLCQVEESTALLE 61
SL++E+ +++L +P ++ + +S E V + R + E+ +A E
Sbjct: 23 SLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLK----------RKNNKSEDESAPKE 72
Query: 62 LVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATR------------ 109
+ + + NM+ VV+++ + L + + + + + ++AT+
Sbjct: 73 VSR--YQDTNMQGVVYELNSYIEQRLDTGGDNQLLLYELSSIIKIATKADGFALYFLGEC 130
Query: 110 ---LFSVQPDSVLEDC--LVPPDSEIVFPLDIG--VVGHVAQTKKMVNVEDVAECPHFSS 162
L P + E L+P P+ G V +VA+++K + VED+ F
Sbjct: 131 NNSLCIFTPPGIKEGKPRLIPAG-----PITQGTTVSAYVAKSRKTLLVEDILGDERFPR 185
Query: 163 FADELTDYKTKNMLATPIMNG-KDVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLK 221
+ + +++L PI+ D++ ++ F ++V L +A++ +
Sbjct: 186 GTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIH 245
Query: 222 IYHLSYLHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMT 281
+ +T LL + F+ + I+ + +N +R ++ +D
Sbjct: 246 QVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHK 305
Query: 282 KEKEFFDVWSVLMGESQPYSGPRTPDGREIVFYKVIDYILHGKEEIKVIPTPSADHWALA 341
++ + D++ + GE + +G+ VF K +EI+ +++
Sbjct: 306 NKELYSDLFDI--GEEK--------EGKP-VFKKT--------KEIR---------FSIE 337
Query: 342 SGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATF 401
G+ VA +G + NI +A AD F + +G+ +N+L MPIV++ ++GV
Sbjct: 338 KGIAGQVARTGEVLNIPDAYADPRFNREVDLY--TGYTTRNILCMPIVSRGS-VIGVVQM 394
Query: 402 YNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRD 461
N+ G F + DE + F ++ + Y ++ E + + + YH C +
Sbjct: 395 VNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSE 454
Query: 462 E----IQLILPTRARLGKEPADCDEDELG--EILKEELPGPTTFDIYEFHFSDLECTELD 515
E +Q LP R C E EL +I E P F +Y H S
Sbjct: 455 EWQGLMQFTLPVRL--------CKEIELFHFDIGPFENMWPGIF-VYMVHRS-------- 497
Query: 516 LVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMT 575
CG + EL E L RF+ S+ K YRR+ YHNW+H VA M+ +L
Sbjct: 498 ---CGTSCF-EL----------EKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQN 543
Query: 576 GKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKF 635
+ +TDLE ++ A LCHD+DHRG +N Y K +PLA L+ +S +E+HH
Sbjct: 544 NH--TLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVS 601
Query: 636 LLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSW 695
+L E NI+ L+ ++E V+ ++ AIIATDLALYF R +++ + +S
Sbjct: 602 ILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQS- 660
Query: 696 VEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQP 755
++ V+ +MMTACDL ++TK W V A + AEFW +GD E L QP
Sbjct: 661 ---------HRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGD-EMKKLGIQP 710
Query: 756 IPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWK 808
IPMMDR+K E+P+ Q+GF + V Y ++ P+ ++N +W+
Sbjct: 711 IPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWE 763
>gi|5729972 phosphodiesterase 10A isoform 2 [Homo sapiens]
Length = 779
Score = 231 bits (588), Expect = 3e-60
Identities = 185/678 (27%), Positives = 312/678 (46%), Gaps = 82/678 (12%)
Query: 138 VVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLATPIMNG-KDVVAVIMAVNKL 196
V +VA+++K + VED+ F + + +++L PI+ D++ ++
Sbjct: 151 VSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHW 210
Query: 197 NGPFFTSEDEDVFLKYLNFATLYLKIYHLSYLHNCETRRGQVLLWSANKVFEELTDIERQ 256
F ++V L +A++ + + +T LL + F+ + I+
Sbjct: 211 GKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSL 270
Query: 257 FHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVLMGESQPYSGPRTPDGREIVFYKV 316
+ +N +R ++ +D ++ + D++ + GE + +G+ VF K
Sbjct: 271 LEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDI--GEEK--------EGKP-VFKKT 319
Query: 317 IDYILHGKEEIKVIPTPSADHWALASGLPSYVAESGFICNIMNASADEMFKFQEGALDDS 376
+EI+ +++ G+ VA +G + NI +A AD F + +
Sbjct: 320 --------KEIR---------FSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLY--T 360
Query: 377 GWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYD 436
G+ +N+L MPIV++ ++GV N+ G F + DE + F ++ + Y
Sbjct: 361 GYTTRNILCMPIVSRGS-VIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYH 419
Query: 437 KMNKLENRKDIAQDMVLYHVKCDRDE----IQLILPTRARLGKEPADCDEDELG--EILK 490
++ E + + + YH C +E +Q LP R C E EL +I
Sbjct: 420 RIRHSECIYRVTMEKLSYHSICTSEEWQGLMQFTLPVRL--------CKEIELFHFDIGP 471
Query: 491 EELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKG 550
E P F +Y H S CG + EL E L RF+ S+ K
Sbjct: 472 FENMWPGIF-VYMVHRS-----------CGTSCF-EL----------EKLCRFIMSVKKN 508
Query: 551 YRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQM 610
YRR+ YHNW+H VA M+ +L + +TDLE ++ A LCHD+DHRG +N Y
Sbjct: 509 YRRVPYHNWKHAVTVAHCMYAILQNNH--TLFTDLERKGLLIACLCHDLDHRGFSNSYLQ 566
Query: 611 KSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLA 670
K +PLA L+ +S +E+HH +L E NI+ L+ ++E V+ ++ AIIATDLA
Sbjct: 567 KFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLA 626
Query: 671 LYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQS 730
LYF R +++ + +S ++ V+ +MMTACDL ++TK W V
Sbjct: 627 LYFGNRKQLEEMYQTGSLNLNNQS----------HRDRVIGLMMTACDLCSVTKLWPVTK 676
Query: 731 KVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFH 790
A + AEFW +GD E L QPIPMMDR+K E+P+ Q+GF + V Y ++
Sbjct: 677 LTANDIYAEFWAEGD-EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQIL 735
Query: 791 EEILPMFDRLQNNRKEWK 808
P+ ++N +W+
Sbjct: 736 PPTEPLLKACRDNLSQWE 753
Score = 78.2 bits (191), Expect = 3e-14
Identities = 47/142 (33%), Positives = 76/142 (53%), Gaps = 6/142 (4%)
Query: 86 LLQADRCSLFMYRQRNGVAELATRLFSVQPDSVLEDCLVPPDSEIVFPLDIGVVGHVAQT 145
L+ ADRC+LF +N EL + LF + + + + EI F ++ G+ G VA+T
Sbjct: 281 LVNADRCALFQVDHKN--KELYSDLFDIGEEKEGKP-VFKKTKEIRFSIEKGIAGQVART 337
Query: 146 KKMVNVEDVAECPHFSSFADELTDYKTKNMLATPIMNGKDVVAVIMAVNKLNGPFFTSED 205
+++N+ D P F+ D T Y T+N+L PI++ V+ V+ VNK++G F+ D
Sbjct: 338 GEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTD 397
Query: 206 EDVFLKYLNFATLYL---KIYH 224
E+ F + F L L +YH
Sbjct: 398 ENNFKMFAVFCALALHCANMYH 419
>gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens]
Length = 809
Score = 142 bits (357), Expect = 2e-33
Identities = 98/327 (29%), Positives = 175/327 (53%), Gaps = 11/327 (3%)
Query: 484 ELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRF 543
E ++L +EL + ++ F ++L L ++ E +++ F+IP + L+ +
Sbjct: 389 EQEDVLAKELEDVNKWGLHVFRIAELSGNR-PLTVIMHTIFQERDLLKTFKIPVDTLITY 447
Query: 544 LFSISKGYRR-ITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHR 602
L ++ Y + YHN H +V Q+ LL T L++ +TDLE A + A HD+DH
Sbjct: 448 LMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHP 507
Query: 603 GTNNLYQMKSQNPLAKLHG-SSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMD 661
G +N + + + + LA ++ SS+LE HHL G LL EE +I+QNL ++Q + + ++
Sbjct: 508 GVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVI 567
Query: 662 IAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLSA 721
++ATD++ + A + +V+ K S V L + R +++ M+ A DLS
Sbjct: 568 DIVLATDMSKHMNLLADLKTMVETKK---VTSSGVLLLDNYSDRIQVLQNMVHCA-DLSN 623
Query: 722 ITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTF 781
TKP ++ + + EF+ QGD ER + PM D++ A+ + K QVGFID++
Sbjct: 624 PTKPLQLYRQWTDRIMEEFFRQGDRERE-RGMEISPMCDKHNAS-VEKSQVGFIDYIVHP 681
Query: 782 VYKEFSRF-HEEILPMFDRLQNNRKEW 807
+++ ++ H + + D L++NR EW
Sbjct: 682 LWETWADLVHPDAQDILDTLEDNR-EW 707
>gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens]
Length = 673
Score = 142 bits (357), Expect = 2e-33
Identities = 98/327 (29%), Positives = 175/327 (53%), Gaps = 11/327 (3%)
Query: 484 ELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRF 543
E ++L +EL + ++ F ++L L ++ E +++ F+IP + L+ +
Sbjct: 253 EQEDVLAKELEDVNKWGLHVFRIAELSGNR-PLTVIMHTIFQERDLLKTFKIPVDTLITY 311
Query: 544 LFSISKGYRR-ITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHR 602
L ++ Y + YHN H +V Q+ LL T L++ +TDLE A + A HD+DH
Sbjct: 312 LMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHP 371
Query: 603 GTNNLYQMKSQNPLAKLHG-SSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMD 661
G +N + + + + LA ++ SS+LE HHL G LL EE +I+QNL ++Q + + ++
Sbjct: 372 GVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVI 431
Query: 662 IAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLSA 721
++ATD++ + A + +V+ K S V L + R +++ M+ A DLS
Sbjct: 432 DIVLATDMSKHMNLLADLKTMVETKK---VTSSGVLLLDNYSDRIQVLQNMVHCA-DLSN 487
Query: 722 ITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTF 781
TKP ++ + + EF+ QGD ER + PM D++ A+ + K QVGFID++
Sbjct: 488 PTKPLQLYRQWTDRIMEEFFRQGDRERE-RGMEISPMCDKHNAS-VEKSQVGFIDYIVHP 545
Query: 782 VYKEFSRF-HEEILPMFDRLQNNRKEW 807
+++ ++ H + + D L++NR EW
Sbjct: 546 LWETWADLVHPDAQDILDTLEDNR-EW 571
>gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens]
Length = 825
Score = 141 bits (356), Expect = 2e-33
Identities = 108/367 (29%), Positives = 188/367 (51%), Gaps = 34/367 (9%)
Query: 487 EILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFS 546
E+L +EL + + F SD L ++ E +++KF+IP + +V ++ +
Sbjct: 302 ELLAQELENLNKWGLNIFCVSDYAGGR-SLTCIMYMIFQERDLLKKFRIPVDTMVTYMLT 360
Query: 547 ISKGYRR-ITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTN 605
+ Y + YHN H +V Q+ LL T L + +TDLE A + A HD+DH G +
Sbjct: 361 LEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVS 420
Query: 606 NLYQMKSQNPLAKLHG-SSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAI 664
N + + + + LA ++ S+LE HHL G LL E+ +I+QNL++RQ + + ++ +
Sbjct: 421 NQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMV 480
Query: 665 IATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITK 724
+ATD++ + A + +V+ K S V L + R +++ M+ A DLS TK
Sbjct: 481 LATDMSKHMTLLADLKTMVETKK---VTSSGVLLLDNYSDRIQVLRNMVHCA-DLSNPTK 536
Query: 725 PWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYK 784
P E+ + + AEF++QGD ER + PM D++ A + K QVGFID++ +++
Sbjct: 537 PLELYRQWTDRIMAEFFQQGDRERE-RGMEISPMCDKH-TASVEKSQVGFIDYIVHPLWE 594
Query: 785 EFSRF-HEEILPMFDRLQNNRKEW----------------------KALADEYEAKVKAL 821
++ H + + D L++NR +W L D+++ ++ L
Sbjct: 595 TWADLVHPDAQEILDTLEDNR-DWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFEL-TL 652
Query: 822 EEKEEEE 828
EE+EEEE
Sbjct: 653 EEEEEEE 659
>gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens]
Length = 860
Score = 141 bits (356), Expect = 2e-33
Identities = 108/367 (29%), Positives = 188/367 (51%), Gaps = 34/367 (9%)
Query: 487 EILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFS 546
E+L +EL + + F SD L ++ E +++KF+IP + +V ++ +
Sbjct: 337 ELLAQELENLNKWGLNIFCVSDYAGGR-SLTCIMYMIFQERDLLKKFRIPVDTMVTYMLT 395
Query: 547 ISKGYRR-ITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTN 605
+ Y + YHN H +V Q+ LL T L + +TDLE A + A HD+DH G +
Sbjct: 396 LEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVS 455
Query: 606 NLYQMKSQNPLAKLHG-SSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAI 664
N + + + + LA ++ S+LE HHL G LL E+ +I+QNL++RQ + + ++ +
Sbjct: 456 NQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMV 515
Query: 665 IATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITK 724
+ATD++ + A + +V+ K S V L + R +++ M+ A DLS TK
Sbjct: 516 LATDMSKHMTLLADLKTMVETKK---VTSSGVLLLDNYSDRIQVLRNMVHCA-DLSNPTK 571
Query: 725 PWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYK 784
P E+ + + AEF++QGD ER + PM D++ A + K QVGFID++ +++
Sbjct: 572 PLELYRQWTDRIMAEFFQQGDRERE-RGMEISPMCDKH-TASVEKSQVGFIDYIVHPLWE 629
Query: 785 EFSRF-HEEILPMFDRLQNNRKEW----------------------KALADEYEAKVKAL 821
++ H + + D L++NR +W L D+++ ++ L
Sbjct: 630 TWADLVHPDAQEILDTLEDNR-DWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFEL-TL 687
Query: 822 EEKEEEE 828
EE+EEEE
Sbjct: 688 EEEEEEE 694
>gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens]
Length = 886
Score = 141 bits (356), Expect = 2e-33
Identities = 108/367 (29%), Positives = 188/367 (51%), Gaps = 34/367 (9%)
Query: 487 EILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFS 546
E+L +EL + + F SD L ++ E +++KF+IP + +V ++ +
Sbjct: 363 ELLAQELENLNKWGLNIFCVSDYAGGR-SLTCIMYMIFQERDLLKKFRIPVDTMVTYMLT 421
Query: 547 ISKGYRR-ITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTN 605
+ Y + YHN H +V Q+ LL T L + +TDLE A + A HD+DH G +
Sbjct: 422 LEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVS 481
Query: 606 NLYQMKSQNPLAKLHG-SSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAI 664
N + + + + LA ++ S+LE HHL G LL E+ +I+QNL++RQ + + ++ +
Sbjct: 482 NQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMV 541
Query: 665 IATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITK 724
+ATD++ + A + +V+ K S V L + R +++ M+ A DLS TK
Sbjct: 542 LATDMSKHMTLLADLKTMVETKK---VTSSGVLLLDNYSDRIQVLRNMVHCA-DLSNPTK 597
Query: 725 PWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYK 784
P E+ + + AEF++QGD ER + PM D++ A + K QVGFID++ +++
Sbjct: 598 PLELYRQWTDRIMAEFFQQGDRERE-RGMEISPMCDKH-TASVEKSQVGFIDYIVHPLWE 655
Query: 785 EFSRF-HEEILPMFDRLQNNRKEW----------------------KALADEYEAKVKAL 821
++ H + + D L++NR +W L D+++ ++ L
Sbjct: 656 TWADLVHPDAQEILDTLEDNR-DWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFEL-TL 713
Query: 822 EEKEEEE 828
EE+EEEE
Sbjct: 714 EEEEEEE 720
>gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens]
Length = 647
Score = 141 bits (356), Expect = 2e-33
Identities = 108/367 (29%), Positives = 188/367 (51%), Gaps = 34/367 (9%)
Query: 487 EILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFS 546
E+L +EL + + F SD L ++ E +++KF+IP + +V ++ +
Sbjct: 124 ELLAQELENLNKWGLNIFCVSDYAGGR-SLTCIMYMIFQERDLLKKFRIPVDTMVTYMLT 182
Query: 547 ISKGYRR-ITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTN 605
+ Y + YHN H +V Q+ LL T L + +TDLE A + A HD+DH G +
Sbjct: 183 LEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVS 242
Query: 606 NLYQMKSQNPLAKLHG-SSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAI 664
N + + + + LA ++ S+LE HHL G LL E+ +I+QNL++RQ + + ++ +
Sbjct: 243 NQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMV 302
Query: 665 IATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITK 724
+ATD++ + A + +V+ K S V L + R +++ M+ A DLS TK
Sbjct: 303 LATDMSKHMTLLADLKTMVETKK---VTSSGVLLLDNYSDRIQVLRNMVHCA-DLSNPTK 358
Query: 725 PWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYK 784
P E+ + + AEF++QGD ER + PM D++ A + K QVGFID++ +++
Sbjct: 359 PLELYRQWTDRIMAEFFQQGDRERE-RGMEISPMCDKH-TASVEKSQVGFIDYIVHPLWE 416
Query: 785 EFSRF-HEEILPMFDRLQNNRKEW----------------------KALADEYEAKVKAL 821
++ H + + D L++NR +W L D+++ ++ L
Sbjct: 417 TWADLVHPDAQEILDTLEDNR-DWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFEL-TL 474
Query: 822 EEKEEEE 828
EE+EEEE
Sbjct: 475 EEEEEEE 481
>gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens]
Length = 606
Score = 136 bits (342), Expect = 9e-32
Identities = 106/365 (29%), Positives = 185/365 (50%), Gaps = 33/365 (9%)
Query: 487 EILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFS 546
E L +EL + + F ++L L ++ E +++ FQIP + L +L
Sbjct: 212 EQLAKELEDTNKWGLDVFKVAELSGNR-PLTAIIFSIFQERDLLKTFQIPADTLATYLLM 270
Query: 547 ISKGYR-RITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTN 605
+ Y + YHN H +VAQ+ LL T L++ +TDLE A + A HD+DH G +
Sbjct: 271 LEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVS 330
Query: 606 NLYQMKSQNPLAKLHG-SSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAI 664
N + + + + LA ++ +S+LE HHL G LL E +I+QNL+ +Q + ++ +
Sbjct: 331 NQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMV 390
Query: 665 IATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTAC-DLSAIT 723
+ATD++ + A + +V+ K + + L L+ I + + C DLS T
Sbjct: 391 LATDMSKHMNLLADLKTMVETK-----KVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPT 445
Query: 724 KPWEVQSKVALLVAAEFWEQGDLER-TVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFV 782
KP + + + AEF++QGD ER + LD PM D++ A + K QVGFID++ +
Sbjct: 446 KPLPLYRQWTDRIMAEFFQQGDRERESGLDIS--PMCDKH-TASVEKSQVGFIDYIAHPL 502
Query: 783 YKEFSRF-HEEILPMFDRLQNNRKEW------KALAD------------EYEAKVKALEE 823
++ ++ H + + D L++NR EW ++ +D ++E ++ EE
Sbjct: 503 WETWADLVHPDAQDLLDTLEDNR-EWYQSKIPRSPSDLTNPERDGPDRFQFELTLEEAEE 561
Query: 824 KEEEE 828
++EEE
Sbjct: 562 EDEEE 566
>gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens]
Length = 680
Score = 136 bits (342), Expect = 9e-32
Identities = 106/365 (29%), Positives = 185/365 (50%), Gaps = 33/365 (9%)
Query: 487 EILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFS 546
E L +EL + + F ++L L ++ E +++ FQIP + L +L
Sbjct: 286 EQLAKELEDTNKWGLDVFKVAELSGNR-PLTAIIFSIFQERDLLKTFQIPADTLATYLLM 344
Query: 547 ISKGYR-RITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTN 605
+ Y + YHN H +VAQ+ LL T L++ +TDLE A + A HD+DH G +
Sbjct: 345 LEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVS 404
Query: 606 NLYQMKSQNPLAKLHG-SSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAI 664
N + + + + LA ++ +S+LE HHL G LL E +I+QNL+ +Q + ++ +
Sbjct: 405 NQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMV 464
Query: 665 IATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTAC-DLSAIT 723
+ATD++ + A + +V+ K + + L L+ I + + C DLS T
Sbjct: 465 LATDMSKHMNLLADLKTMVETK-----KVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPT 519
Query: 724 KPWEVQSKVALLVAAEFWEQGDLER-TVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFV 782
KP + + + AEF++QGD ER + LD PM D++ A + K QVGFID++ +
Sbjct: 520 KPLPLYRQWTDRIMAEFFQQGDRERESGLDIS--PMCDKH-TASVEKSQVGFIDYIAHPL 576
Query: 783 YKEFSRF-HEEILPMFDRLQNNRKEW------KALAD------------EYEAKVKALEE 823
++ ++ H + + D L++NR EW ++ +D ++E ++ EE
Sbjct: 577 WETWADLVHPDAQDLLDTLEDNR-EWYQSKIPRSPSDLTNPERDGPDRFQFELTLEEAEE 635
Query: 824 KEEEE 828
++EEE
Sbjct: 636 EDEEE 640
>gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens]
Length = 712
Score = 136 bits (342), Expect = 9e-32
Identities = 106/365 (29%), Positives = 185/365 (50%), Gaps = 33/365 (9%)
Query: 487 EILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVLVRFLFS 546
E L +EL + + F ++L L ++ E +++ FQIP + L +L
Sbjct: 318 EQLAKELEDTNKWGLDVFKVAELSGNR-PLTAIIFSIFQERDLLKTFQIPADTLATYLLM 376
Query: 547 ISKGYR-RITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTN 605
+ Y + YHN H +VAQ+ LL T L++ +TDLE A + A HD+DH G +
Sbjct: 377 LEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVS 436
Query: 606 NLYQMKSQNPLAKLHG-SSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAI 664
N + + + + LA ++ +S+LE HHL G LL E +I+QNL+ +Q + ++ +
Sbjct: 437 NQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMV 496
Query: 665 IATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTAC-DLSAIT 723
+ATD++ + A + +V+ K + + L L+ I + + C DLS T
Sbjct: 497 LATDMSKHMNLLADLKTMVETK-----KVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPT 551
Query: 724 KPWEVQSKVALLVAAEFWEQGDLER-TVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFV 782
KP + + + AEF++QGD ER + LD PM D++ A + K QVGFID++ +
Sbjct: 552 KPLPLYRQWTDRIMAEFFQQGDRERESGLDIS--PMCDKH-TASVEKSQVGFIDYIAHPL 608
Query: 783 YKEFSRF-HEEILPMFDRLQNNRKEW------KALAD------------EYEAKVKALEE 823
++ ++ H + + D L++NR EW ++ +D ++E ++ EE
Sbjct: 609 WETWADLVHPDAQDLLDTLEDNR-EWYQSKIPRSPSDLTNPERDGPDRFQFELTLEEAEE 667
Query: 824 KEEEE 828
++EEE
Sbjct: 668 EDEEE 672
>gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 132 bits (331), Expect = 2e-30
Identities = 92/317 (29%), Positives = 166/317 (52%), Gaps = 23/317 (7%)
Query: 515 DLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLM 574
+++ C MY++LG+VR F I L R+LF + YR +HN+RH F VAQ M++++
Sbjct: 63 EMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVW 122
Query: 575 TGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLA-KLHGSSILERHHLEFG 633
L+ ++ + ++TA +CHD+DH G NN YQ+ ++ LA + + S LE HH
Sbjct: 123 LCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVA 182
Query: 634 KFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKK 693
+L+E NI+ N+ + + M I+ATD+A + +I+D ++++K
Sbjct: 183 FQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARH-------AEIMD---SFKEKM 232
Query: 694 SWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQ 753
+Y + E ++ +++ CD+S +P EV + E++ Q D E++ +
Sbjct: 233 ENFDYSNEE--HMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKS--EG 288
Query: 754 QPI-PMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFH---EEILPMFDRLQNNRKEWKA 809
P+ P MDR+K + Q+GFI FV +++ ++ EEI M L +R ++
Sbjct: 289 LPVAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEI--MLQPLWESRDRYEE 345
Query: 810 LADEYEAKVKALEEKEE 826
L + +K L++K +
Sbjct: 346 L-KRIDDAMKELQKKTD 361
>gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 132 bits (331), Expect = 2e-30
Identities = 92/317 (29%), Positives = 166/317 (52%), Gaps = 23/317 (7%)
Query: 515 DLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLM 574
+++ C MY++LG+VR F I L R+LF + YR +HN+RH F VAQ M++++
Sbjct: 63 EMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVW 122
Query: 575 TGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLA-KLHGSSILERHHLEFG 633
L+ ++ + ++TA +CHD+DH G NN YQ+ ++ LA + + S LE HH
Sbjct: 123 LCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVA 182
Query: 634 KFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKK 693
+L+E NI+ N+ + + M I+ATD+A + +I+D ++++K
Sbjct: 183 FQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARH-------AEIMD---SFKEKM 232
Query: 694 SWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQ 753
+Y + E ++ +++ CD+S +P EV + E++ Q D E++ +
Sbjct: 233 ENFDYSNEE--HMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKS--EG 288
Query: 754 QPI-PMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFH---EEILPMFDRLQNNRKEWKA 809
P+ P MDR+K + Q+GFI FV +++ ++ EEI M L +R ++
Sbjct: 289 LPVAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEI--MLQPLWESRDRYEE 345
Query: 810 LADEYEAKVKALEEKEE 826
L + +K L++K +
Sbjct: 346 L-KRIDDAMKELQKKTD 361
>gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens]
Length = 567
Score = 132 bits (331), Expect = 2e-30
Identities = 92/317 (29%), Positives = 166/317 (52%), Gaps = 23/317 (7%)
Query: 515 DLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLM 574
+++ C MY++LG+VR F I L R+LF + YR +HN+RH F VAQ M++++
Sbjct: 244 EMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVW 303
Query: 575 TGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLA-KLHGSSILERHHLEFG 633
L+ ++ + ++TA +CHD+DH G NN YQ+ ++ LA + + S LE HH
Sbjct: 304 LCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVA 363
Query: 634 KFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKK 693
+L+E NI+ N+ + + M I+ATD+A + +I+D ++++K
Sbjct: 364 FQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARH-------AEIMD---SFKEKM 413
Query: 694 SWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQ 753
+Y + E ++ +++ CD+S +P EV + E++ Q D E++ +
Sbjct: 414 ENFDYSNEE--HMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKS--EG 469
Query: 754 QPI-PMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFH---EEILPMFDRLQNNRKEWKA 809
P+ P MDR+K + Q+GFI FV +++ ++ EEI M L +R ++
Sbjct: 470 LPVAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEI--MLQPLWESRDRYEE 526
Query: 810 LADEYEAKVKALEEKEE 826
L + +K L++K +
Sbjct: 527 L-KRIDDAMKELQKKTD 542
>gi|48762748 phosphodiesterase 9A isoform n [Homo sapiens]
Length = 552
Score = 132 bits (331), Expect = 2e-30
Identities = 92/317 (29%), Positives = 166/317 (52%), Gaps = 23/317 (7%)
Query: 515 DLVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLM 574
+++ C MY++LG+VR F I L R+LF + YR +HN+RH F VAQ M++++
Sbjct: 229 EMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVW 288
Query: 575 TGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLA-KLHGSSILERHHLEFG 633
L+ ++ + ++TA +CHD+DH G NN YQ+ ++ LA + + S LE HH
Sbjct: 289 LCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVA 348
Query: 634 KFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKK 693
+L+E NI+ N+ + + M I+ATD+A + +I+D ++++K
Sbjct: 349 FQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARH-------AEIMD---SFKEKM 398
Query: 694 SWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQ 753
+Y + E ++ +++ CD+S +P EV + E++ Q D E++ +
Sbjct: 399 ENFDYSNEE--HMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKS--EG 454
Query: 754 QPI-PMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFH---EEILPMFDRLQNNRKEWKA 809
P+ P MDR+K + Q+GFI FV +++ ++ EEI M L +R ++
Sbjct: 455 LPVAPFMDRDKVTK-ATAQIGFIKFVLIPMFETVTKLFPMVEEI--MLQPLWESRDRYEE 511
Query: 810 LADEYEAKVKALEEKEE 826
L + +K L++K +
Sbjct: 512 L-KRIDDAMKELQKKTD 527
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,020,246
Number of Sequences: 37866
Number of extensions: 1426206
Number of successful extensions: 4440
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 69
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 4129
Number of HSP's gapped (non-prelim): 114
length of query: 854
length of database: 18,247,518
effective HSP length: 111
effective length of query: 743
effective length of database: 14,044,392
effective search space: 10434983256
effective search space used: 10434983256
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.