Search of human proteins with 103472031

Search of human proteins with 103472031

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|103472031 family with sequence similarity 62 (C2 domain
containing), member C [Homo sapiens]
         (886 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|103472031 family with sequence similarity 62 (C2 domain conta...  1804   0.0  
gi|45387945 family with sequence similarity 62 (C2 domain contai...   652   0.0  
gi|14149680 extended synaptotagmin-like protein 1 [Homo sapiens]      462   e-130
gi|40068038 B/K protein [Homo sapiens]                                 79   2e-14
gi|227496489 multiple C2 domains, transmembrane 2 isoform 2 [Hom...    74   6e-13
gi|227496440 multiple C2 domains, transmembrane 2 isoform 1 [Hom...    74   6e-13
gi|211059429 synaptotagmin II [Homo sapiens]                           74   6e-13
gi|31543670 synaptotagmin II [Homo sapiens]                            74   6e-13
gi|110227631 synaptotagmin-like 3 [Homo sapiens]                       73   1e-12
gi|14249614 synaptotagmin-like 1 [Homo sapiens]                        72   3e-12
gi|50582996 multiple C2 domains, transmembrane 1 isoform S [Homo...    71   4e-12
gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Hom...    71   4e-12
gi|45504376 synaptotagmin VI [Homo sapiens]                            70   7e-12
gi|92859638 synaptotagmin V [Homo sapiens]                             70   1e-11
gi|209447073 synaptotagmin I [Homo sapiens]                            69   3e-11
gi|5032139 synaptotagmin I [Homo sapiens]                              69   3e-11
gi|209447070 synaptotagmin I [Homo sapiens]                            69   3e-11
gi|227496504 multiple C2 domains, transmembrane 2 isoform 3 [Hom...    68   4e-11
gi|28376627 synaptotagmin IX [Homo sapiens]                            67   6e-11
gi|38570146 synaptotagmin VII [Homo sapiens]                           67   7e-11
gi|15011900 synaptotagmin-like 2 isoform b [Homo sapiens]              65   2e-10
gi|244790020 synaptotagmin-like 2 isoform i [Homo sapiens]             65   2e-10
gi|244790013 synaptotagmin-like 2 isoform g [Homo sapiens]             65   2e-10
gi|46255068 synaptotagmin-like 2 isoform f [Homo sapiens]              65   2e-10
gi|46255066 synaptotagmin-like 2 isoform e [Homo sapiens]              65   2e-10
gi|46255064 synaptotagmin-like 2 isoform d [Homo sapiens]              65   2e-10
gi|46255062 synaptotagmin-like 2 isoform c [Homo sapiens]              65   2e-10
gi|238550198 synaptotagmin III [Homo sapiens]                          65   2e-10
gi|238550196 synaptotagmin III [Homo sapiens]                          65   2e-10
gi|14150054 synaptotagmin III [Homo sapiens]                           65   2e-10

>gi|103472031 family with sequence similarity 62 (C2 domain
           containing), member C [Homo sapiens]
          Length = 886

 Score = 1804 bits (4673), Expect = 0.0
 Identities = 886/886 (100%), Positives = 886/886 (100%)

Query: 1   MRAEEPCAPGAPSALGAQRTPGPELRLSSQLLPELCTFVVRVLFYLGPVYLAGYLGLSIT 60
           MRAEEPCAPGAPSALGAQRTPGPELRLSSQLLPELCTFVVRVLFYLGPVYLAGYLGLSIT
Sbjct: 1   MRAEEPCAPGAPSALGAQRTPGPELRLSSQLLPELCTFVVRVLFYLGPVYLAGYLGLSIT 60

Query: 61  WLLLGALLWMWWRRNRRGKLGRLAAAFEFLDNEREFISRELRGQHLPAWIHFPDVERVEW 120
           WLLLGALLWMWWRRNRRGKLGRLAAAFEFLDNEREFISRELRGQHLPAWIHFPDVERVEW
Sbjct: 61  WLLLGALLWMWWRRNRRGKLGRLAAAFEFLDNEREFISRELRGQHLPAWIHFPDVERVEW 120

Query: 121 ANKIISQTWPYLSMIMESKFREKLEPKIREKSIHLRTFTFTKLYFGQKCPRVNGVKAHTN 180
           ANKIISQTWPYLSMIMESKFREKLEPKIREKSIHLRTFTFTKLYFGQKCPRVNGVKAHTN
Sbjct: 121 ANKIISQTWPYLSMIMESKFREKLEPKIREKSIHLRTFTFTKLYFGQKCPRVNGVKAHTN 180

Query: 181 TCNRRRVTVDLQICYIGDCEISVELQKIQAGVNGIQLQGTLRVILEPLLVDKPFVGAVTV 240
           TCNRRRVTVDLQICYIGDCEISVELQKIQAGVNGIQLQGTLRVILEPLLVDKPFVGAVTV
Sbjct: 181 TCNRRRVTVDLQICYIGDCEISVELQKIQAGVNGIQLQGTLRVILEPLLVDKPFVGAVTV 240

Query: 241 FFLQKPHLQINWTGLTNLLDAPGINDVSDSLLEDLIATHLVLPNRVTVPVKKGLDLTNLR 300
           FFLQKPHLQINWTGLTNLLDAPGINDVSDSLLEDLIATHLVLPNRVTVPVKKGLDLTNLR
Sbjct: 241 FFLQKPHLQINWTGLTNLLDAPGINDVSDSLLEDLIATHLVLPNRVTVPVKKGLDLTNLR 300

Query: 301 FPLPCGVIRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSIGLQHFRSRTIYRNLNPTWNEV 360
           FPLPCGVIRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSIGLQHFRSRTIYRNLNPTWNEV
Sbjct: 301 FPLPCGVIRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSIGLQHFRSRTIYRNLNPTWNEV 360

Query: 361 FEFMVYEVPGQDLEVDLYDEDTDRDDFLGSLQICLGDVMTNRVVDEWFVLNDTTSGRLHL 420
           FEFMVYEVPGQDLEVDLYDEDTDRDDFLGSLQICLGDVMTNRVVDEWFVLNDTTSGRLHL
Sbjct: 361 FEFMVYEVPGQDLEVDLYDEDTDRDDFLGSLQICLGDVMTNRVVDEWFVLNDTTSGRLHL 420

Query: 421 RLEWLSLLTDQEVLTEDHGGLSTAILVVFLESACNLPRNPFDYLNGEYRAKKLSRFARNK 480
           RLEWLSLLTDQEVLTEDHGGLSTAILVVFLESACNLPRNPFDYLNGEYRAKKLSRFARNK
Sbjct: 421 RLEWLSLLTDQEVLTEDHGGLSTAILVVFLESACNLPRNPFDYLNGEYRAKKLSRFARNK 480

Query: 481 VSKDPSSYVKLSVGKKTHTSKTCPHNKDPVWSQVFSFFVHNVATERLHLKVLDDDQECAL 540
           VSKDPSSYVKLSVGKKTHTSKTCPHNKDPVWSQVFSFFVHNVATERLHLKVLDDDQECAL
Sbjct: 481 VSKDPSSYVKLSVGKKTHTSKTCPHNKDPVWSQVFSFFVHNVATERLHLKVLDDDQECAL 540

Query: 541 GMLEVPLCQILPYADLTLEQRFQLDHSGLDSLISMRLVLRFLQVEERELGSPYTGPEALK 600
           GMLEVPLCQILPYADLTLEQRFQLDHSGLDSLISMRLVLRFLQVEERELGSPYTGPEALK
Sbjct: 541 GMLEVPLCQILPYADLTLEQRFQLDHSGLDSLISMRLVLRFLQVEERELGSPYTGPEALK 600

Query: 601 KGPLLIKKVATNQGPKAQPQEEGPTDLPCPPDPASDTKDVSRSTTTTTSATTVATEPTSQ 660
           KGPLLIKKVATNQGPKAQPQEEGPTDLPCPPDPASDTKDVSRSTTTTTSATTVATEPTSQ
Sbjct: 601 KGPLLIKKVATNQGPKAQPQEEGPTDLPCPPDPASDTKDVSRSTTTTTSATTVATEPTSQ 660

Query: 661 ETGPEPKGKDSAKRFCEPIGEKKSPATIFLTVPGPHSPGPIKSPRPMKCPASPFAWPPKR 720
           ETGPEPKGKDSAKRFCEPIGEKKSPATIFLTVPGPHSPGPIKSPRPMKCPASPFAWPPKR
Sbjct: 661 ETGPEPKGKDSAKRFCEPIGEKKSPATIFLTVPGPHSPGPIKSPRPMKCPASPFAWPPKR 720

Query: 721 LAPSMSSLNSLASSCFDLADISLNIEGGDLRRRQLGEIQLTVRYVCLRRCLSVLINGCRN 780
           LAPSMSSLNSLASSCFDLADISLNIEGGDLRRRQLGEIQLTVRYVCLRRCLSVLINGCRN
Sbjct: 721 LAPSMSSLNSLASSCFDLADISLNIEGGDLRRRQLGEIQLTVRYVCLRRCLSVLINGCRN 780

Query: 781 LTPCTSSGADPYVRVYLLPERKWACRKKTSVKRKTLEPLFDETFEFFVPMEEVKKRSLDV 840
           LTPCTSSGADPYVRVYLLPERKWACRKKTSVKRKTLEPLFDETFEFFVPMEEVKKRSLDV
Sbjct: 781 LTPCTSSGADPYVRVYLLPERKWACRKKTSVKRKTLEPLFDETFEFFVPMEEVKKRSLDV 840

Query: 841 AVKNSRPLGSHRRKELGKVLIDLSKEDLIKGFSQWYELTPNGQPRS 886
           AVKNSRPLGSHRRKELGKVLIDLSKEDLIKGFSQWYELTPNGQPRS
Sbjct: 841 AVKNSRPLGSHRRKELGKVLIDLSKEDLIKGFSQWYELTPNGQPRS 886


>gi|45387945 family with sequence similarity 62 (C2 domain
           containing) member B [Homo sapiens]
          Length = 893

 Score =  652 bits (1682), Expect = 0.0
 Identities = 365/898 (40%), Positives = 538/898 (59%), Gaps = 81/898 (9%)

Query: 2   RAEEPCA-PGAPSALGAQRTPGPELRLSSQLLPELCTFVVRVLFYLGPVYLAGYLGLSIT 60
           R E P A  G      A   PG  L +    LP L   + R    L PVY  GYLGLS +
Sbjct: 53  RGEGPEAGAGGAGGRAAPENPGGVLSVE---LPGLLAQLARSFALLLPVYALGYLGLSFS 109

Query: 61  WLLLGALLWMWWRRNRRGKLGRLAAAFEFLDNEREFISRELRGQHLPAWIHFPDVERVEW 120
           W+LL   L  W RR+R  K  RL  A   L++E   +   +R   LPAW+HFPD ER EW
Sbjct: 110 WVLLALALLAWCRRSRGLKALRLCRALALLEDEERVVRLGVRACDLPAWVHFPDTERAEW 169

Query: 121 ANKIISQTWPYLSMIMESKFREKLEPKIREKSIHLRTFTFTKLYFGQKCPRVNGVKAHTN 180
            NK +   WP++   +E  FRE +EP +R  + HL TF+FTK+  GQ+  R+NGVK +T 
Sbjct: 170 LNKTVKHMWPFICQFIEKLFRETIEPAVRGANTHLSTFSFTKVDVGQQPLRINGVKVYTE 229

Query: 181 TCNRRRVTVDLQICYIGDCEISVELQK--IQAGVNGIQLQGTLRVILEPLLVDKPFVGAV 238
             ++R++ +DLQI ++G+CEI +E+++   +AGV  IQ+ GT+RVILEPL+ D P VGA+
Sbjct: 230 NVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVKSIQIHGTMRVILEPLIGDMPLVGAL 289

Query: 239 TVFFLQKPHLQINWTGLTNLLDAPGINDVSDSLLEDLIATHLVLPNRVTVPVKKGLDLTN 298
           ++FFL+KP L+INWTGLTNLLD PG+N +SD+++ D+I+ +LVLPNR+TVP+   + +  
Sbjct: 290 SIFFLRKPLLEINWTGLTNLLDVPGLNGLSDTIILDIISNYLVLPNRITVPLVSEVQIAQ 349

Query: 299 LRFPLPCGVIRVHLLEAEQLAQKDNFLG--LRGKSDPYAKVSIGLQHFRSRTIYRNLNPT 356
           LRFP+P GV+R+H +EA+ L  KD +L   ++GKSDPY  + +G Q F+SR I  NL+P 
Sbjct: 350 LRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPK 409

Query: 357 WNEVFEFMVYEVPGQDLEVDLYDEDTDRDDFLGSLQICLGDVMTNRVVDEWFVLNDTTSG 416
           WNEV+E +VYE PGQ+LE++L+DED D+DDFLGSL I L +V   R++DEWF L++   G
Sbjct: 410 WNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPKG 469

Query: 417 RLHLRLEWLSLLTD----QEVLT-------EDHGGLSTAILVVFLESACNLPRNPFDYLN 465
           +LHLRLEWL+L+ +     +VLT       + + GLS+A+L+++L+SA NLP        
Sbjct: 470 KLHLRLEWLTLMPNASNLDKVLTDIKADKDQANDGLSSALLILYLDSARNLP-------- 521

Query: 466 GEYRAKKLSRFARNKVSKDPSSYVKLSVGKKTHTSKTCPHNKDPVWSQVFSFFVHNVATE 525
                      +  K+S +P+  V++SVG K   SK      +PVW + F+FF+HN   +
Sbjct: 522 -----------SGKKISSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQ 570

Query: 526 RLHLKVLDDDQECALGMLEVPLCQILPYADLTLEQRFQLDHSGLDSLISMRLVLRFLQVE 585
            L ++V D+  +C+LG L+VPL Q+L   D+T+ QRFQL +SG +S I M++ LR L +E
Sbjct: 571 DLEVEVRDEQHQCSLGNLKVPLSQLLTSEDMTVSQRFQLSNSGPNSTIKMKIALRVLHLE 630

Query: 586 ERELGSPYTGPEALKKGPLLIKKVATNQGPKAQPQEEGPTDLPCPPDPASDTKDVSRSTT 645
           +RE    +     +K+  +      + +G K   +    + +   P P         +T 
Sbjct: 631 KRERPPDHQHSAQVKRPSV------SKEGRKTSIK----SHMSGSPGPGGS------NTA 674

Query: 646 TTTSATTVATEPTSQETGPEPKGKDSAKRFCEPIGEKKSPATIFLTVPGPHSPGPIKSPR 705
            +T     + +P  +E    P   ++  +    +G   S            SPG I    
Sbjct: 675 PSTPVIGGSDKPGMEEKAQPP---EAGPQGLHDLGRSSSSLLA--------SPGHISVKE 723

Query: 706 PMKCPASPFAWPPKRLAPSMSSLNSLASSCFDLADISLNIEGG-DLRRRQLGEIQLTVRY 764
           P                PS++S  SL  +  +L      +E G  L +  LG+IQLT+R+
Sbjct: 724 P---------------TPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRH 768

Query: 765 VCLRRCLSVLINGCRNLTPCTSSGADPYVRVYLLPERKWACRKKTSVKRKTLEPLFDETF 824
              R  L V+++ CRNL   +  G+DPYVR+YLLP+++ + R+KT V +KTL P+FD++F
Sbjct: 769 SSQRNKLIVVVHACRNLIAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSF 828

Query: 825 EFFVPMEEVKKRSLDVAVKNSRPLGSHRRKELGKVLIDLSKEDLIKGFSQWYELTPNG 882
           +F V + EV++R+LDVAVKNS    S  +  LGKVL+ L+ E+L KG++QWY+LT +G
Sbjct: 829 DFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTEDG 886


>gi|14149680 extended synaptotagmin-like protein 1 [Homo sapiens]
          Length = 1104

 Score =  462 bits (1189), Expect = e-130
 Identities = 260/606 (42%), Positives = 375/606 (61%), Gaps = 42/606 (6%)

Query: 4   EEPCAPGAPSALGAQRTPGPELRLSSQLLPELCTFVVRVLFYLGPVYLAGYLGLSITWLL 63
           + P A   P      +  GP    + + L  L +F  R+L  + PVYLAG +GLS+ ++L
Sbjct: 26  QPPAAHAKPDPGSGGQPAGPGA--AGEALAVLTSFGRRLLVLI-PVYLAGAVGLSVGFVL 82

Query: 64  LGALLWMWWRRNRRGKLGRLAAAFEFLDNEREFISRELRGQH--LPAWIHFPDVERVEWA 121
            G  L++ WRR R  K   L AA + LD+E +  ++ L   H  LPAW+ FPDVE+ EW 
Sbjct: 83  FGLALYLGWRRVRDEKERSLRAARQLLDDEEQLTAKTLYMSHRELPAWVSFPDVEKAEWL 142

Query: 122 NKIISQTWPYLSMIMESKFREKLEPKIREKSIHLRTFTFTKLYFGQKCPRVNGVKAHTNT 181
           NKI++Q WP+L   ME    E + P +R  + HL+TFTFT++  G+K  R+ GVK H   
Sbjct: 143 NKIVAQVWPFLGQYMEKLLAETVAPAVRGSNPHLQTFTFTRVELGEKPLRIIGVKVHPGQ 202

Query: 182 CNRRRVTVDLQICYIGDCEISVELQKI--QAGVNGIQLQGTLRVILEPLLVDKPFVGAVT 239
             + ++ +DL I Y+GD +I VE++K   +AGV G+QL G LRVILEPL+ D PFVGAV+
Sbjct: 203 -RKEQILLDLNISYVGDVQIDVEVKKYFCKAGVKGMQLHGVLRVILEPLIGDLPFVGAVS 261

Query: 240 VFFLQKPHLQINWTGLTNLLDAPGINDVSDSLLEDLIATHLVLPNRVTVPVKKGL-DLTN 298
           +FF+++P L INWTG+TNLLD PG++ +SD+++ D IA  LVLPNR+ VP+   L D+  
Sbjct: 262 MFFIRRPTLDINWTGMTNLLDIPGLSSLSDTMIMDSIAAFLVLPNRLLVPLVPDLQDVAQ 321

Query: 299 LRFPLPCGVIRVHLLEAEQLAQKDNFLG--LRGKSDPYAKVSIGLQHFRSRTIYRNLNPT 356
           LR PLP G+IR+HLL A  L+ KD ++   + GKSDPYA V +G Q F SR I   LNP 
Sbjct: 322 LRSPLPRGIIRIHLLAARGLSSKDKYVKGLIEGKSDPYALVRLGTQTFCSRVIDEELNPQ 381

Query: 357 WNEVFEFMVYEVPGQDLEVDLYDEDTDRDDFLGSLQICLGDVMTNRVVDEWFVLNDTTSG 416
           W E +E MV+EVPGQ++EV+++D+D D+DDFLG +++ +G V+   V+D+WF L     G
Sbjct: 382 WGETYEVMVHEVPGQEIEVEVFDKDPDKDDFLGRMKLDVGKVLQASVLDDWFPLQG-GQG 440

Query: 417 RLHLRLEWLSLLTDQEVLTED---HGGLST-------AILVVFLESACNLPRNPFDYLNG 466
           ++HLRLEWLSLL+D E L +    + G+S+       AILVV+L+ A +LP         
Sbjct: 441 QVHLRLEWLSLLSDAEKLEQVLQWNWGVSSRPDPPSAAILVVYLDRAQDLP--------- 491

Query: 467 EYRAKKLSRFARNKVSKDPSSYVKLSVGKKTHTSKTCPHNKDPVWSQVFSFFVHNVATER 526
                        K +K+P+  V+LS+   T  SK       PVW + F FF+ +  ++ 
Sbjct: 492 -----------LKKGNKEPNPMVQLSIQDVTQESKAVYSTNCPVWEEAFRFFLQDPQSQE 540

Query: 527 LHLKVLDDDQECALGMLEVPLCQILPYADLTLEQRFQLDHSGLDSLISMRLVLRFLQVEE 586
           L ++V DD +   LG L +PL ++L   +L L+Q FQL  SG +S + M+LV+R L ++ 
Sbjct: 541 LDVQVKDDSRALTLGALTLPLARLLTAPELILDQWFQLSSSGPNSRLYMKLVMRILYLDS 600

Query: 587 RELGSP 592
            E+  P
Sbjct: 601 SEICFP 606



 Score =  176 bits (446), Expect = 9e-44
 Identities = 103/271 (38%), Positives = 149/271 (54%), Gaps = 34/271 (12%)

Query: 307 VIRVHLLEAEQLAQKDNFLG--LRGKSDPYAKVSIGLQHFRSRTIYRNLNPTWNEVFEFM 364
           V+R+H+LEA+ L  KD FLG  ++GKSDPY K+ +  + FRS  +  +LNP WNEVFE +
Sbjct: 648 VLRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKLAGRSFRSHVVREDLNPRWNEVFEVI 707

Query: 365 VYEVPGQDLEVDLYDEDTDRDDFLGSLQICLGDVMTNRVVDEWFVLNDTTSGRLHLRLEW 424
           V  VPGQ+LEV+++D+D D+DDFLG  ++ L  V+ +  +DEW  L D  SGRLHLRLE 
Sbjct: 708 VTSVPGQELEVEVFDKDLDKDDFLGRCKVRLTTVLNSGFLDEWLTLEDVPSGRLHLRLER 767

Query: 425 LS-----------LLTDQEVLTEDHGGLSTAILVVFLESACNLPRNPFDYLNGEYRAKKL 473
           L+           L  +  + T+    L+ A+L +++E A +LP                
Sbjct: 768 LTPRPTAAELEEVLQVNSLIQTQKSAELAAALLSIYMERAEDLP---------------- 811

Query: 474 SRFARNKVSKDPSSYVKLSVGKKTHTSKTCPHNKDPVWSQVFSFFVHNVATERLHLKVLD 533
                 K +K  S Y  L+VG  +H +KT      PVW +  SF +    TE L L+V  
Sbjct: 812 ----LRKGTKHLSPYATLTVGDSSHKTKTISQTSAPVWDESASFLIRKPHTESLELQVRG 867

Query: 534 DDQECALGMLEVPLCQILPYADLTLEQRFQL 564
           +     LG L +PL ++L    L L++ F L
Sbjct: 868 EGTG-VLGSLSLPLSELLVADQLCLDRWFTL 897



 Score =  107 bits (267), Expect = 5e-23
 Identities = 51/127 (40%), Positives = 85/127 (66%)

Query: 755  LGEIQLTVRYVCLRRCLSVLINGCRNLTPCTSSGADPYVRVYLLPERKWACRKKTSVKRK 814
            LG+++LT+ Y    R L  +++GCR+L        DPYV + LLP++    +++TS K++
Sbjct: 972  LGQVKLTLWYYSEERKLVSIVHGCRSLRQNGRDPPDPYVSLLLLPDKNRGTKRRTSQKKR 1031

Query: 815  TLEPLFDETFEFFVPMEEVKKRSLDVAVKNSRPLGSHRRKELGKVLIDLSKEDLIKGFSQ 874
            TL P F+E FE+ +P++E ++R LDV+VK++    S  R+ LGKV +DL++ DL +G ++
Sbjct: 1032 TLSPEFNERFEWELPLDEAQRRKLDVSVKSNSSFMSRERELLGKVQLDLAETDLSQGVAR 1091

Query: 875  WYELTPN 881
            WY+L  N
Sbjct: 1092 WYDLMDN 1098


>gi|40068038 B/K protein [Homo sapiens]
          Length = 474

 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 54/173 (31%), Positives = 91/173 (52%), Gaps = 18/173 (10%)

Query: 719 KRLAPSMSSLNSLASSCFDLADISLNIEGGDLRRRQLGEIQLTVRYVCLRRCLSVLINGC 778
           ++  P + SL+S +     L D  +      L + QLG +  + +Y  L   L+V +   
Sbjct: 155 RKFEPHLYSLDSNSDDVDSLTDEEI------LSKYQLGMLHFSTQYDLLHNHLTVRVIEA 208

Query: 779 RNLTPCTS--------SGADPYVRVYLLPERKWACRKKTSVKRKTLEPLFDETFEFFVPM 830
           R+L P  S        + ++PYV++ LLP++K +  K+T VKRKT +P+F+E + F +P 
Sbjct: 209 RDLPPPISHDGSRQDMAHSNPYVKICLLPDQKNS--KQTGVKRKTQKPVFEERYTFEIPF 266

Query: 831 EEVKKRSLDVAVKNSRPLGSHRRKELGKVLIDLSKEDLIKGFSQWYELTPNGQ 883
            E ++R+L + V +      H    +GKV + L + DL+KG   W  L P+ Q
Sbjct: 267 LEAQRRTLLLTVVDFDKFSRH--CVIGKVSVPLCEVDLVKGGHWWKALIPSSQ 317



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 32/86 (37%), Positives = 52/86 (60%), Gaps = 1/86 (1%)

Query: 754 QLGEIQLTVRYVCLRRCLSV-LINGCRNLTPCTSSGADPYVRVYLLPERKWACRKKTSVK 812
           +LGE+ L++ Y+     L+V +I   + L    S G+DP+V++ L+   K    KKTS  
Sbjct: 321 ELGELLLSLNYLPSAGRLNVDVIRAKQLLQTDVSQGSDPFVKIQLVHGLKLVKTKKTSFL 380

Query: 813 RKTLEPLFDETFEFFVPMEEVKKRSL 838
           R T++P ++E+F F VP EE++  SL
Sbjct: 381 RGTIDPFYNESFSFKVPQEELENASL 406


>gi|227496489 multiple C2 domains, transmembrane 2 isoform 2 [Homo
           sapiens]
          Length = 823

 Score = 73.9 bits (180), Expect = 6e-13
 Identities = 74/282 (26%), Positives = 120/282 (42%), Gaps = 30/282 (10%)

Query: 287 TVPVKKGLDLTNLRFPLPCGVIRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSI-GLQHFR 345
           +VP +    L+NL  P    ++ +HL E   L  +D      G SDPY K  + G   ++
Sbjct: 176 SVPGEASDGLSNLPSPFAY-LLTIHLKEGRNLVVRDRC----GTSDPYVKFKLNGKTLYK 230

Query: 346 SRTIYRNLNPTWNEVFEFMVYEVPGQDLEVDLYDEDTDRDDFLGSLQICLGDVMTNRVVD 405
           S+ IY+NLNP W+E+    +  +  Q L V +YD D    DF+GS  + L D+  NR  +
Sbjct: 231 SKVIYKNLNPVWDEIVVLPIQSLD-QKLRVKVYDRDLTTSDFMGSAFVILSDLELNRTTE 289

Query: 406 EWFVLNDTTS-----GRLHLRLEWLSLLTD---QEVLTEDHGGLSTAILVVFLESACNLP 457
               L D  S     G + L L  +    D              S + L+  L  + +L 
Sbjct: 290 HILKLEDPNSLEDDMGVIVLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRNLRLSESLK 349

Query: 458 RNPFDYLNGEYRAKKLSRFARNKVSKDPSS--YVKLSVGKKTHTSKTCPHNKDPVWSQVF 515
           +N     NG      ++      VS    +  +V+L +G + + SKT   + +P W + F
Sbjct: 350 KN--QLWNG---IISITLLEGKNVSGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQF 404

Query: 516 SFFVHNVATERLHLKVLDDDQE--------CALGMLEVPLCQ 549
            F   +     L ++V   D +        C + +  +PL Q
Sbjct: 405 DFHYFSDRMGILDIEVWGKDNKKHEERLGTCKVDISALPLKQ 446



 Score = 67.8 bits (164), Expect = 4e-11
 Identities = 36/91 (39%), Positives = 56/91 (61%), Gaps = 6/91 (6%)

Query: 306 GVIRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSIGLQHFRSRTIYRNLNPTWNEVFEFMV 365
           G+++V +L+A  L   D      GKSDP+  + +G    ++ T+Y+NLNP WN+VF F +
Sbjct: 509 GILQVKVLKAADLLAAD----FSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPI 564

Query: 366 YEVPGQDLEVDLYDEDTDR-DDFLGSLQICL 395
            ++    LEV ++DED D+  DFLG + I L
Sbjct: 565 KDI-HDVLEVTVFDEDGDKPPDFLGKVAIPL 594



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 60/301 (19%), Positives = 126/301 (41%), Gaps = 31/301 (10%)

Query: 284 NRVTVPVKKGLDLTNLRFP-------LPCGVIRVHLLEAEQLAQKDNFLGLRGKSDPYAK 336
           NR  +   K   + NLR         L  G+I + LLE + ++           ++ + +
Sbjct: 327 NRKRLSASKSSLIRNLRLSESLKKNQLWNGIISITLLEGKNVSGGS-------MTEMFVQ 379

Query: 337 VSIGLQHFRSRTIYRNLNPTWNEVFEFMVYEVPGQDLEVDLYDEDTDR-DDFLGSLQICL 395
           + +G Q ++S+T+ ++ NP W E F+F  +      L+++++ +D  + ++ LG+ ++ +
Sbjct: 380 LKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDRMGILDIEVWGKDNKKHEERLGTCKVDI 439

Query: 396 GDVMTNRVVDEWFVLNDTTSGRLHL-RLEWLSLLTDQEVLTEDHGGLSTAILVVFLESAC 454
             +   +       L+      L L  L   + ++  ++       LS    +       
Sbjct: 440 SALPLKQANCLELPLDSCLGALLMLVTLTPCAGVSVSDLCVCPLADLSERKQITQRYCLQ 499

Query: 455 NLPRNPFDYLNGEYRAKKLSRFARNKVSKDPSSYVKLSVGKKTHTSKTCPHNKDPVWSQV 514
           N  ++  D    + +  K +       S     +  L +G     + T   N +P W++V
Sbjct: 500 NSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKV 559

Query: 515 FSFFVHNVATERLHLKVLDDDQECA---LGMLEVPL---------CQILPYADLTLEQRF 562
           F+F + ++  + L + V D+D +     LG + +PL         C +L   D  LEQ F
Sbjct: 560 FTFPIKDI-HDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNCYVLKNKD--LEQAF 616

Query: 563 Q 563
           +
Sbjct: 617 K 617


>gi|227496440 multiple C2 domains, transmembrane 2 isoform 1 [Homo
           sapiens]
          Length = 878

 Score = 73.9 bits (180), Expect = 6e-13
 Identities = 74/282 (26%), Positives = 120/282 (42%), Gaps = 30/282 (10%)

Query: 287 TVPVKKGLDLTNLRFPLPCGVIRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSI-GLQHFR 345
           +VP +    L+NL  P    ++ +HL E   L  +D      G SDPY K  + G   ++
Sbjct: 176 SVPGEASDGLSNLPSPFAY-LLTIHLKEGRNLVVRDRC----GTSDPYVKFKLNGKTLYK 230

Query: 346 SRTIYRNLNPTWNEVFEFMVYEVPGQDLEVDLYDEDTDRDDFLGSLQICLGDVMTNRVVD 405
           S+ IY+NLNP W+E+    +  +  Q L V +YD D    DF+GS  + L D+  NR  +
Sbjct: 231 SKVIYKNLNPVWDEIVVLPIQSLD-QKLRVKVYDRDLTTSDFMGSAFVILSDLELNRTTE 289

Query: 406 EWFVLNDTTS-----GRLHLRLEWLSLLTD---QEVLTEDHGGLSTAILVVFLESACNLP 457
               L D  S     G + L L  +    D              S + L+  L  + +L 
Sbjct: 290 HILKLEDPNSLEDDMGVIVLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRNLRLSESLK 349

Query: 458 RNPFDYLNGEYRAKKLSRFARNKVSKDPSS--YVKLSVGKKTHTSKTCPHNKDPVWSQVF 515
           +N     NG      ++      VS    +  +V+L +G + + SKT   + +P W + F
Sbjct: 350 KN--QLWNG---IISITLLEGKNVSGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQF 404

Query: 516 SFFVHNVATERLHLKVLDDDQE--------CALGMLEVPLCQ 549
            F   +     L ++V   D +        C + +  +PL Q
Sbjct: 405 DFHYFSDRMGILDIEVWGKDNKKHEERLGTCKVDISALPLKQ 446



 Score = 67.8 bits (164), Expect = 4e-11
 Identities = 36/91 (39%), Positives = 56/91 (61%), Gaps = 6/91 (6%)

Query: 306 GVIRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSIGLQHFRSRTIYRNLNPTWNEVFEFMV 365
           G+++V +L+A  L   D      GKSDP+  + +G    ++ T+Y+NLNP WN+VF F +
Sbjct: 509 GILQVKVLKAADLLAAD----FSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPI 564

Query: 366 YEVPGQDLEVDLYDEDTDR-DDFLGSLQICL 395
            ++    LEV ++DED D+  DFLG + I L
Sbjct: 565 KDI-HDVLEVTVFDEDGDKPPDFLGKVAIPL 594



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 60/301 (19%), Positives = 126/301 (41%), Gaps = 31/301 (10%)

Query: 284 NRVTVPVKKGLDLTNLRFP-------LPCGVIRVHLLEAEQLAQKDNFLGLRGKSDPYAK 336
           NR  +   K   + NLR         L  G+I + LLE + ++           ++ + +
Sbjct: 327 NRKRLSASKSSLIRNLRLSESLKKNQLWNGIISITLLEGKNVSGGS-------MTEMFVQ 379

Query: 337 VSIGLQHFRSRTIYRNLNPTWNEVFEFMVYEVPGQDLEVDLYDEDTDR-DDFLGSLQICL 395
           + +G Q ++S+T+ ++ NP W E F+F  +      L+++++ +D  + ++ LG+ ++ +
Sbjct: 380 LKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDRMGILDIEVWGKDNKKHEERLGTCKVDI 439

Query: 396 GDVMTNRVVDEWFVLNDTTSGRLHL-RLEWLSLLTDQEVLTEDHGGLSTAILVVFLESAC 454
             +   +       L+      L L  L   + ++  ++       LS    +       
Sbjct: 440 SALPLKQANCLELPLDSCLGALLMLVTLTPCAGVSVSDLCVCPLADLSERKQITQRYCLQ 499

Query: 455 NLPRNPFDYLNGEYRAKKLSRFARNKVSKDPSSYVKLSVGKKTHTSKTCPHNKDPVWSQV 514
           N  ++  D    + +  K +       S     +  L +G     + T   N +P W++V
Sbjct: 500 NSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKV 559

Query: 515 FSFFVHNVATERLHLKVLDDDQECA---LGMLEVPL---------CQILPYADLTLEQRF 562
           F+F + ++  + L + V D+D +     LG + +PL         C +L   D  LEQ F
Sbjct: 560 FTFPIKDI-HDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNCYVLKNKD--LEQAF 616

Query: 563 Q 563
           +
Sbjct: 617 K 617


>gi|211059429 synaptotagmin II [Homo sapiens]
          Length = 419

 Score = 73.9 bits (180), Expect = 6e-13
 Identities = 47/151 (31%), Positives = 84/151 (55%), Gaps = 16/151 (10%)

Query: 744 NIEGGDLRR-RQLGEIQLTVRYVCLRRCLSVLINGCRNLTPCTSSG-ADPYVRVYLLPER 801
           +++GG+     +LG+I  ++RYV     L+V I   +NL      G +DPYV+++L+   
Sbjct: 259 DLQGGEKEEPEKLGDICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNG 318

Query: 802 KWACRKKTSVKRKTLEPLFDETFEFFVPMEEVKKRSLDVAVKNSRPLGSHRRKELGKVLI 861
           K   +KKT+VK+KTL P F+E+F F +P E+++K  + V V +   LG  + + +GK+ +
Sbjct: 319 KRLKKKKTTVKKKTLNPYFNESFSFEIPFEQIQKVQVVVTVLDYDKLG--KNEAIGKIFV 376

Query: 862 DLSK--------EDLI----KGFSQWYELTP 880
             +          D++    +  +QW+ L P
Sbjct: 377 GSNATGTELRHWSDMLANPRRPIAQWHSLKP 407



 Score = 64.3 bits (155), Expect = 5e-10
 Identities = 41/125 (32%), Positives = 70/125 (56%), Gaps = 5/125 (4%)

Query: 755 LGEIQLTVRYVCLRRCLSVLINGCRNLTPCTSSG-ADPYVRVYLLPERKWACRKKTSVKR 813
           LG++Q ++ Y      L+V +     L      G +DPYV+V+LLP++K   + +T V R
Sbjct: 140 LGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDKKK--KYETKVHR 197

Query: 814 KTLEPLFDETFEFFVPMEEVKKRSLDVAVKNSRPLGSHRRKELGKVLIDLSKEDLIKGFS 873
           KTL P F+ETF F VP +E+  ++L +A+ +      H    +G+V + ++  DL +   
Sbjct: 198 KTLNPAFNETFTFKVPYQELGGKTLVMAIYDFDRFSKH--DIIGEVKVPMNTVDLGQPIE 255

Query: 874 QWYEL 878
           +W +L
Sbjct: 256 EWRDL 260



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 32/116 (27%), Positives = 59/116 (50%), Gaps = 10/116 (8%)

Query: 298 NLRFPLPCGVIRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSI---GLQHFRSRTIYRNLN 354
           +L +      + V +L+A +L   D    + G SDPY KV +     + + ++   + LN
Sbjct: 146 SLDYDFQANQLTVGVLQAAELPALD----MGGTSDPYVKVFLLPDKKKKYETKVHRKTLN 201

Query: 355 PTWNEVFEFMV--YEVPGQDLEVDLYDEDT-DRDDFLGSLQICLGDVMTNRVVDEW 407
           P +NE F F V   E+ G+ L + +YD D   + D +G +++ +  V   + ++EW
Sbjct: 202 PAFNETFTFKVPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEW 257



 Score = 43.5 bits (101), Expect = 9e-04
 Identities = 43/156 (27%), Positives = 74/156 (47%), Gaps = 23/156 (14%)

Query: 289 PVKKGLDLTNLRFPLPCGVIRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSI-----GLQH 343
           P K G   T+LR+    G + V +LEA+ L + D    + G SDPY K+ +      L+ 
Sbjct: 268 PEKLGDICTSLRYVPTAGKLTVCILEAKNLKKMD----VGGLSDPYVKIHLMQNGKRLKK 323

Query: 344 FRSRTIYRNLNPTWNEVFEFMVYEVPGQDLE-----VDLYDED-TDRDDFLGSLQICLGD 397
            ++    + LNP +NE F F   E+P + ++     V + D D   +++ +G  +I +G 
Sbjct: 324 KKTTVKKKTLNPYFNESFSF---EIPFEQIQKVQVVVTVLDYDKLGKNEAIG--KIFVGS 378

Query: 398 VMTNRVVDEWFVLNDTTSGRLHLRLEWLSLLTDQEV 433
             T   +  W   +D  +       +W SL  ++EV
Sbjct: 379 NATGTELRHW---SDMLANPRRPIAQWHSLKPEEEV 411


>gi|31543670 synaptotagmin II [Homo sapiens]
          Length = 419

 Score = 73.9 bits (180), Expect = 6e-13
 Identities = 47/151 (31%), Positives = 84/151 (55%), Gaps = 16/151 (10%)

Query: 744 NIEGGDLRR-RQLGEIQLTVRYVCLRRCLSVLINGCRNLTPCTSSG-ADPYVRVYLLPER 801
           +++GG+     +LG+I  ++RYV     L+V I   +NL      G +DPYV+++L+   
Sbjct: 259 DLQGGEKEEPEKLGDICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNG 318

Query: 802 KWACRKKTSVKRKTLEPLFDETFEFFVPMEEVKKRSLDVAVKNSRPLGSHRRKELGKVLI 861
           K   +KKT+VK+KTL P F+E+F F +P E+++K  + V V +   LG  + + +GK+ +
Sbjct: 319 KRLKKKKTTVKKKTLNPYFNESFSFEIPFEQIQKVQVVVTVLDYDKLG--KNEAIGKIFV 376

Query: 862 DLSK--------EDLI----KGFSQWYELTP 880
             +          D++    +  +QW+ L P
Sbjct: 377 GSNATGTELRHWSDMLANPRRPIAQWHSLKP 407



 Score = 64.3 bits (155), Expect = 5e-10
 Identities = 41/125 (32%), Positives = 70/125 (56%), Gaps = 5/125 (4%)

Query: 755 LGEIQLTVRYVCLRRCLSVLINGCRNLTPCTSSG-ADPYVRVYLLPERKWACRKKTSVKR 813
           LG++Q ++ Y      L+V +     L      G +DPYV+V+LLP++K   + +T V R
Sbjct: 140 LGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDKKK--KYETKVHR 197

Query: 814 KTLEPLFDETFEFFVPMEEVKKRSLDVAVKNSRPLGSHRRKELGKVLIDLSKEDLIKGFS 873
           KTL P F+ETF F VP +E+  ++L +A+ +      H    +G+V + ++  DL +   
Sbjct: 198 KTLNPAFNETFTFKVPYQELGGKTLVMAIYDFDRFSKH--DIIGEVKVPMNTVDLGQPIE 255

Query: 874 QWYEL 878
           +W +L
Sbjct: 256 EWRDL 260



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 32/116 (27%), Positives = 59/116 (50%), Gaps = 10/116 (8%)

Query: 298 NLRFPLPCGVIRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSI---GLQHFRSRTIYRNLN 354
           +L +      + V +L+A +L   D    + G SDPY KV +     + + ++   + LN
Sbjct: 146 SLDYDFQANQLTVGVLQAAELPALD----MGGTSDPYVKVFLLPDKKKKYETKVHRKTLN 201

Query: 355 PTWNEVFEFMV--YEVPGQDLEVDLYDEDT-DRDDFLGSLQICLGDVMTNRVVDEW 407
           P +NE F F V   E+ G+ L + +YD D   + D +G +++ +  V   + ++EW
Sbjct: 202 PAFNETFTFKVPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEW 257



 Score = 43.5 bits (101), Expect = 9e-04
 Identities = 43/156 (27%), Positives = 74/156 (47%), Gaps = 23/156 (14%)

Query: 289 PVKKGLDLTNLRFPLPCGVIRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSI-----GLQH 343
           P K G   T+LR+    G + V +LEA+ L + D    + G SDPY K+ +      L+ 
Sbjct: 268 PEKLGDICTSLRYVPTAGKLTVCILEAKNLKKMD----VGGLSDPYVKIHLMQNGKRLKK 323

Query: 344 FRSRTIYRNLNPTWNEVFEFMVYEVPGQDLE-----VDLYDED-TDRDDFLGSLQICLGD 397
            ++    + LNP +NE F F   E+P + ++     V + D D   +++ +G  +I +G 
Sbjct: 324 KKTTVKKKTLNPYFNESFSF---EIPFEQIQKVQVVVTVLDYDKLGKNEAIG--KIFVGS 378

Query: 398 VMTNRVVDEWFVLNDTTSGRLHLRLEWLSLLTDQEV 433
             T   +  W   +D  +       +W SL  ++EV
Sbjct: 379 NATGTELRHW---SDMLANPRRPIAQWHSLKPEEEV 411


>gi|110227631 synaptotagmin-like 3 [Homo sapiens]
          Length = 542

 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 61/216 (28%), Positives = 96/216 (44%), Gaps = 24/216 (11%)

Query: 678 PIGEKKSPATIFLTVPGPHSPGPIKSPRPMKCPASPFAWP---PKRLAPSM--------S 726
           P+ E +   +    V  P    P+    P KC  +P       P   APS          
Sbjct: 160 PVSESQCSRSPGRKVSAPDILKPLNQEDP-KCSTNPILKQQNLPSSPAPSTIFSGGFRHG 218

Query: 727 SLNSLASSCFDLADISLNIEGGDLRRRQLGEIQLTVRYVCLRRCLSVLINGCRNLT--PC 784
           SL S+ S+C ++     N +  ++     GEI+  + Y      L + I  C+NL     
Sbjct: 219 SLISIDSTCTEMG----NFDNANVT----GEIEFAIHYCFKTHSLEICIKACKNLAYGEE 270

Query: 785 TSSGADPYVRVYLLPERKWACRKKTSVKRKTLEPLFDETFEFFVPMEEVKKRSLDVAVKN 844
                +PYV+ YLLP+R    ++KT V+R T++P F ET ++ V   ++  R L V+V +
Sbjct: 271 KKKKCNPYVKTYLLPDRSSQGKRKTGVQRNTVDPTFQETLKYQVAPAQLVTRQLQVSVWH 330

Query: 845 SRPLGSHRRKELGKVLIDLSKEDLIKGFSQWYELTP 880
              L   RR  LG+V+I L+  D     +Q +   P
Sbjct: 331 LGTLA--RRVFLGEVIIPLATWDFEDSTTQSFRWHP 364


>gi|14249614 synaptotagmin-like 1 [Homo sapiens]
          Length = 550

 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 54/166 (32%), Positives = 85/166 (51%), Gaps = 9/166 (5%)

Query: 720 RLAPSMSSLNSLASSCFDLADISLNIEGGDLRRRQL-GEIQLTVRYVCLRRCLSVLINGC 778
           R+  S SS++SL SS    + +SL+   GD    Q+ G +   + Y      L V +  C
Sbjct: 222 RMLSSSSSVSSLNSSTLSGSQMSLS---GDAEAVQVRGSVHFALHYEPGAAELRVHVIQC 278

Query: 779 RNLTPCTSSGADPYVRVYLLPERKWACRKKTSVKRKTLEPLFDETFEFFVPMEEVKKRSL 838
           + L       +DPYV+ YLLP+++   ++KT+VK++ L P+F+ET  + VP  E++ R L
Sbjct: 279 QGLAAARRRRSDPYVKSYLLPDKQ--SKRKTAVKKRNLNPVFNETLRYSVPQAELQGRVL 336

Query: 839 DVAVKNSRPLGSHRRKELGKVLIDLSKEDLIKGFSQWYELTPNGQP 884
            ++V +   LG  R   LG+V + L   D       W  L P   P
Sbjct: 337 SLSVWHRESLG--RNIFLGEVEVPLDTWDW-GSEPTWLPLQPRVPP 379



 Score = 40.8 bits (94), Expect = 0.006
 Identities = 17/52 (32%), Positives = 31/52 (59%)

Query: 775 INGCRNLTPCTSSGADPYVRVYLLPERKWACRKKTSVKRKTLEPLFDETFEF 826
           +   R+L P  +   D YV+ ++LP+   A R++T V R++L P+F+ T  +
Sbjct: 416 VKEARDLLPLRAGSLDTYVQCFVLPDDSQASRQRTRVVRRSLSPVFNHTMVY 467



 Score = 38.1 bits (87), Expect = 0.036
 Identities = 30/94 (31%), Positives = 49/94 (52%), Gaps = 11/94 (11%)

Query: 308 IRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSI--GLQHFRSRTIY-RNLNPTWNEVFEFM 364
           +RVH+++ + LA        R +SDPY K  +    Q  R   +  RNLNP +NE   + 
Sbjct: 271 LRVHVIQCQGLAA-----ARRRRSDPYVKSYLLPDKQSKRKTAVKKRNLNPVFNETLRYS 325

Query: 365 V--YEVPGQDLEVDLYD-EDTDRDDFLGSLQICL 395
           V   E+ G+ L + ++  E   R+ FLG +++ L
Sbjct: 326 VPQAELQGRVLSLSVWHRESLGRNIFLGEVEVPL 359


>gi|50582996 multiple C2 domains, transmembrane 1 isoform S [Homo
           sapiens]
          Length = 778

 Score = 71.2 bits (173), Expect = 4e-12
 Identities = 64/262 (24%), Positives = 116/262 (44%), Gaps = 34/262 (12%)

Query: 306 GVIRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSIGLQHFRSRTIYRNLNPTWNEVFEFMV 365
           G++ + L+E   L   D+     G SDPY K  +G Q ++S+ + + LNP W E F+F +
Sbjct: 249 GIVSITLIEGRDLKAMDS----NGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHL 304

Query: 366 YEVPGQDLEVDLYDEDT-DRDDFLGSLQICLGDVMTNRVVDEWFVLNDTTSGRLHLRLE- 423
           YE  G  +++  +D+D   RDDF+G  Q+ L              L+   + +L L+LE 
Sbjct: 305 YEERGGVIDITAWDKDAGKRDDFIGRCQVDLS------------ALSREQTHKLELQLEE 352

Query: 424 ----WLSLLTDQEVLTEDHGGLSTAIL--------VVFLESACNLPRNPFDYLNGEYRAK 471
                + L+T     T     LS   L        ++   S   +  N  D    + +  
Sbjct: 353 GEGHLVLLVTLTASATVSISDLSVNSLEDQKEREEILKRYSPLRIFHNLKDVGFLQVKVI 412

Query: 472 KLSRFARNKVSKDPSSYVKLSVGKKTHTSKTCPHNKDPVWSQVFSFFVHNVATERLHLKV 531
           +        V+     +  + +      + T   N +P W++VF+F + ++ +  L + V
Sbjct: 413 RAEGLMAADVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKDIHSV-LEVTV 471

Query: 532 LDDDQECA---LGMLEVPLCQI 550
            D+D++ +   LG + +PL  I
Sbjct: 472 YDEDRDRSADFLGKVAIPLLSI 493



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 48/157 (30%), Positives = 80/157 (50%), Gaps = 22/157 (14%)

Query: 306 GVIRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSIGLQHFRSRTIYRNLNPTWNEVFEFMV 365
           G ++V ++ AE L   D    + GKSDP+  V +      + T+Y+NLNP WN+VF F +
Sbjct: 405 GFLQVKVIRAEGLMAAD----VTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNI 460

Query: 366 YEVPGQDLEVDLYDEDTDRD-DFLGSLQICLGDVMTNRVVDEWFVLND-----TTSGRLH 419
            ++    LEV +YDED DR  DFLG + I L  +       + +VL +      T G ++
Sbjct: 461 KDIHSV-LEVTVYDEDRDRSADFLGKVAIPLLSIQNGE--QKAYVLKNKQLTGPTKGVIY 517

Query: 420 LRLEWL---------SLLTDQEVLTEDHGGLSTAILV 447
           L ++ +         +L+  ++   E+   LS  +L+
Sbjct: 518 LEIDVIFNAVKASLRTLIPKEQKYIEEENRLSKQLLL 554



 Score = 53.5 bits (127), Expect = 8e-07
 Identities = 37/105 (35%), Positives = 54/105 (51%), Gaps = 7/105 (6%)

Query: 310 VHLLEAEQLAQKDNFLGLRGKSDPYAKVSIGLQH-FRSRTIYRNLNPTWNEVFEFMVYEV 368
           + L   + LA +D      G SDPY K  IG +  FRS+ I++NLNP W E    +V  +
Sbjct: 44  ITLRRGQSLAARDR----GGTSDPYVKFKIGGKEVFRSKIIHKNLNPVWEEKACILVDHL 99

Query: 369 PGQDLEVDLYDEDTD-RDDFLGSLQICLGDVMTNRVVDEWFVLND 412
             + L + ++D D   +DDF+GS  + L  +  NR  D    L D
Sbjct: 100 -REPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLTLKD 143



 Score = 31.2 bits (69), Expect = 4.5
 Identities = 35/124 (28%), Positives = 53/124 (42%), Gaps = 24/124 (19%)

Query: 450 LESACNLPR-------NPFDYLNGE--------YRAKKLSRFARNKVSKDPSS----YVK 490
           L+SACNLP        N     N E        Y+     R  ++  ++D       YVK
Sbjct: 7   LKSACNLPFICNKKIINTAGTSNAEVPLADPGMYQLDITLRRGQSLAARDRGGTSDPYVK 66

Query: 491 LSVG-KKTHTSKTCPHNKDPVWSQVFSFFVHNVATERLHLKVLDDD---QECALGMLEVP 546
             +G K+   SK    N +PVW +     V ++  E L++KV D D   Q+  +G   + 
Sbjct: 67  FKIGGKEVFRSKIIHKNLNPVWEEKACILVDHL-REPLYIKVFDYDFGLQDDFMGSAFLD 125

Query: 547 LCQI 550
           L Q+
Sbjct: 126 LTQL 129


>gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Homo
           sapiens]
          Length = 999

 Score = 71.2 bits (173), Expect = 4e-12
 Identities = 64/262 (24%), Positives = 116/262 (44%), Gaps = 34/262 (12%)

Query: 306 GVIRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSIGLQHFRSRTIYRNLNPTWNEVFEFMV 365
           G++ + L+E   L   D+     G SDPY K  +G Q ++S+ + + LNP W E F+F +
Sbjct: 470 GIVSITLIEGRDLKAMDS----NGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHL 525

Query: 366 YEVPGQDLEVDLYDEDT-DRDDFLGSLQICLGDVMTNRVVDEWFVLNDTTSGRLHLRLE- 423
           YE  G  +++  +D+D   RDDF+G  Q+ L              L+   + +L L+LE 
Sbjct: 526 YEERGGVIDITAWDKDAGKRDDFIGRCQVDLS------------ALSREQTHKLELQLEE 573

Query: 424 ----WLSLLTDQEVLTEDHGGLSTAIL--------VVFLESACNLPRNPFDYLNGEYRAK 471
                + L+T     T     LS   L        ++   S   +  N  D    + +  
Sbjct: 574 GEGHLVLLVTLTASATVSISDLSVNSLEDQKEREEILKRYSPLRIFHNLKDVGFLQVKVI 633

Query: 472 KLSRFARNKVSKDPSSYVKLSVGKKTHTSKTCPHNKDPVWSQVFSFFVHNVATERLHLKV 531
           +        V+     +  + +      + T   N +P W++VF+F + ++ +  L + V
Sbjct: 634 RAEGLMAADVTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNIKDIHSV-LEVTV 692

Query: 532 LDDDQECA---LGMLEVPLCQI 550
            D+D++ +   LG + +PL  I
Sbjct: 693 YDEDRDRSADFLGKVAIPLLSI 714



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 48/157 (30%), Positives = 80/157 (50%), Gaps = 22/157 (14%)

Query: 306 GVIRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSIGLQHFRSRTIYRNLNPTWNEVFEFMV 365
           G ++V ++ AE L   D    + GKSDP+  V +      + T+Y+NLNP WN+VF F +
Sbjct: 626 GFLQVKVIRAEGLMAAD----VTGKSDPFCVVELNNDRLLTHTVYKNLNPEWNKVFTFNI 681

Query: 366 YEVPGQDLEVDLYDEDTDRD-DFLGSLQICLGDVMTNRVVDEWFVLND-----TTSGRLH 419
            ++    LEV +YDED DR  DFLG + I L  +       + +VL +      T G ++
Sbjct: 682 KDIHSV-LEVTVYDEDRDRSADFLGKVAIPLLSIQNGE--QKAYVLKNKQLTGPTKGVIY 738

Query: 420 LRLEWL---------SLLTDQEVLTEDHGGLSTAILV 447
           L ++ +         +L+  ++   E+   LS  +L+
Sbjct: 739 LEIDVIFNAVKASLRTLIPKEQKYIEEENRLSKQLLL 775



 Score = 53.5 bits (127), Expect = 8e-07
 Identities = 37/105 (35%), Positives = 54/105 (51%), Gaps = 7/105 (6%)

Query: 310 VHLLEAEQLAQKDNFLGLRGKSDPYAKVSIGLQH-FRSRTIYRNLNPTWNEVFEFMVYEV 368
           + L   + LA +D      G SDPY K  IG +  FRS+ I++NLNP W E    +V  +
Sbjct: 265 ITLRRGQSLAARDR----GGTSDPYVKFKIGGKEVFRSKIIHKNLNPVWEEKACILVDHL 320

Query: 369 PGQDLEVDLYDEDTD-RDDFLGSLQICLGDVMTNRVVDEWFVLND 412
             + L + ++D D   +DDF+GS  + L  +  NR  D    L D
Sbjct: 321 -REPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLTLKD 364



 Score = 30.8 bits (68), Expect = 5.8
 Identities = 24/73 (32%), Positives = 37/73 (50%), Gaps = 7/73 (9%)

Query: 482 SKDPSSYVKLSVG-KKTHTSKTCPHNKDPVWSQVFSFFVHNVATERLHLKVLDDD---QE 537
           + DP  YVK  +G K+   SK    N +PVW +     V ++  E L++KV D D   Q+
Sbjct: 281 TSDP--YVKFKIGGKEVFRSKIIHKNLNPVWEEKACILVDHL-REPLYIKVFDYDFGLQD 337

Query: 538 CALGMLEVPLCQI 550
             +G   + L Q+
Sbjct: 338 DFMGSAFLDLTQL 350


>gi|45504376 synaptotagmin VI [Homo sapiens]
          Length = 425

 Score = 70.5 bits (171), Expect = 7e-12
 Identities = 49/141 (34%), Positives = 75/141 (53%), Gaps = 10/141 (7%)

Query: 744 NIEGGDLRR---RQLGEIQLTVRYVCLRRCLSVLINGCRNLTPCTSSGA-DPYVRVYLLP 799
           +++G D +    +  G+I  ++RY      L V I    +L      G+ DPYV++YLLP
Sbjct: 131 SVDGEDAKSEATKSCGKINFSLRYDYETETLIVRILKAFDLPAKDFCGSSDPYVKIYLLP 190

Query: 800 ERKWACRKKTSVKRKTLEPLFDETFEFFVPMEEVKKRSLDVAVKNSRPLGSHRRKELGKV 859
           +RK  C+ +T V RKTL P FDE F F VP EE+  R L ++V +      H    +G+V
Sbjct: 191 DRK--CKLQTRVHRKTLNPTFDENFHFPVPYEELADRKLHLSVFDFDRFSRH--DMIGEV 246

Query: 860 LID--LSKEDLIKGFSQWYEL 878
           ++D      DL +  S W ++
Sbjct: 247 ILDNLFEASDLSRETSIWKDI 267



 Score = 60.5 bits (145), Expect = 7e-09
 Identities = 39/125 (31%), Positives = 70/125 (56%), Gaps = 5/125 (4%)

Query: 755 LGEIQLTVRYVCLRRCLSVLINGCRNLTPCTSSG-ADPYVRVYLLPERKWACRKKTSVKR 813
           LGEI  ++ Y+     L++ +  CRNL     +G +DPYV+V LL + +   +KKT++K+
Sbjct: 277 LGEIMFSLCYLPTAGRLTLTVIKCRNLKAMDITGYSDPYVKVSLLCDGRRLKKKKTTIKK 336

Query: 814 KTLEPLFDETFEFFVPMEEVKKRSLDVAVKNSRPLGSHRRKELGKVLIDLSKEDLIKGFS 873
            TL P+++E   F +P E + + SL ++V +   +G    + +G   + ++ E L  G  
Sbjct: 337 NTLNPVYNEAIIFDIPPENMDQVSLLISVMDYDRVG--HNEIIGVCRVGITAEGL--GRD 392

Query: 874 QWYEL 878
            W E+
Sbjct: 393 HWNEM 397



 Score = 38.1 bits (87), Expect = 0.036
 Identities = 30/100 (30%), Positives = 49/100 (49%), Gaps = 10/100 (10%)

Query: 298 NLRFPLPCGVIRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSIGLQH---FRSRTIYRNLN 354
           +LR+      + V +L+A  L  KD      G SDPY K+ +        ++R   + LN
Sbjct: 151 SLRYDYETETLIVRILKAFDLPAKD----FCGSSDPYVKIYLLPDRKCKLQTRVHRKTLN 206

Query: 355 PTWNEVFEFMV--YEVPGQDLEVDLYDEDT-DRDDFLGSL 391
           PT++E F F V   E+  + L + ++D D   R D +G +
Sbjct: 207 PTFDENFHFPVPYEELADRKLHLSVFDFDRFSRHDMIGEV 246



 Score = 31.6 bits (70), Expect = 3.4
 Identities = 25/92 (27%), Positives = 47/92 (51%), Gaps = 16/92 (17%)

Query: 292 KGLDLTNLRFPL----PCGVIRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSIGLQHFRSR 347
           + +DL  + F L      G + + +++   L   D    + G SDPY KVS+     R +
Sbjct: 273 ESVDLGEIMFSLCYLPTAGRLTLTVIKCRNLKAMD----ITGYSDPYVKVSLLCDGRRLK 328

Query: 348 ----TIYRN-LNPTWNEVFEFMVYEVPGQDLE 374
               TI +N LNP +NE    +++++P ++++
Sbjct: 329 KKKTTIKKNTLNPVYNEA---IIFDIPPENMD 357


>gi|92859638 synaptotagmin V [Homo sapiens]
          Length = 386

 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 41/131 (31%), Positives = 74/131 (56%), Gaps = 5/131 (3%)

Query: 752 RRQLGEIQLTVRYVCLRRCLSVLINGCRNLTPCTSSG-ADPYVRVYLLPERKWACRKKTS 810
           + +LG+I  ++RYV     L+V++   +NL      G +DPYV+V+LL   K   +KKT+
Sbjct: 237 QEKLGDICFSLRYVPTAGKLTVIVLEAKNLKKMDVGGLSDPYVKVHLLQGGKKVRKKKTT 296

Query: 811 VKRKTLEPLFDETFEFFVPMEEVKKRSLDVAVKNSRPLGSHRRKELGKVLIDLSKEDLIK 870
           +K+ TL P ++E F F VP ++V+K  +++ V +   LG  + + +G+V +  +      
Sbjct: 297 IKKNTLNPYYNEAFSFEVPCDQVQKVQVELTVLDYDKLG--KNEAIGRVAVGAAAGG--A 352

Query: 871 GFSQWYELTPN 881
           G   W ++  N
Sbjct: 353 GLRHWADMLAN 363



 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 47/128 (36%), Positives = 66/128 (51%), Gaps = 5/128 (3%)

Query: 752 RRQLGEIQLTVRYVCLRRCLSVLINGCRNLTPCTSSGA-DPYVRVYLLPERKWACRKKTS 810
           + +LG +Q ++ Y      L V I     L      G+ DPYVRVYLLP+++   R +T 
Sbjct: 106 KHELGRLQYSLDYDFQSGQLLVGILQAMGLAALDLGGSSDPYVRVYLLPDKRR--RYETK 163

Query: 811 VKRKTLEPLFDETFEFFVPMEEVKKRSLDVAVKNSRPLGSHRRKELGKVLIDLSKEDLIK 870
           V R+TL P F ETF F VP  E+  R L +AV +       R   +G+V + +S  DL +
Sbjct: 164 VHRQTLNPHFGETFAFKVPYVELGGRVLVMAVYDFDRFS--RNDAIGEVRVPMSSVDLGR 221

Query: 871 GFSQWYEL 878
               W EL
Sbjct: 222 PVQAWREL 229



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 34/92 (36%), Positives = 50/92 (54%), Gaps = 9/92 (9%)

Query: 298 NLRFPLPCGVIRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSI--GLQHFRSR--TIYRN- 352
           +LR+    G + V +LEA+ L + D    + G SDPY KV +  G +  R +  TI +N 
Sbjct: 246 SLRYVPTAGKLTVIVLEAKNLKKMD----VGGLSDPYVKVHLLQGGKKVRKKKTTIKKNT 301

Query: 353 LNPTWNEVFEFMVYEVPGQDLEVDLYDEDTDR 384
           LNP +NE F F V     Q ++V+L   D D+
Sbjct: 302 LNPYYNEAFSFEVPCDQVQKVQVELTVLDYDK 333


>gi|209447073 synaptotagmin I [Homo sapiens]
          Length = 422

 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 38/111 (34%), Positives = 67/111 (60%), Gaps = 3/111 (2%)

Query: 752 RRQLGEIQLTVRYVCLRRCLSVLINGCRNLTPCTSSG-ADPYVRVYLLPERKWACRKKTS 810
           + +LG+I  ++RYV     L+V+I   +NL      G +DPYV+++L+   K   +KKT+
Sbjct: 271 QEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTT 330

Query: 811 VKRKTLEPLFDETFEFFVPMEEVKKRSLDVAVKNSRPLGSHRRKELGKVLI 861
           +K+ TL P ++E+F F VP E+++K  + V V +   +G  +   +GKV +
Sbjct: 331 IKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIG--KNDAIGKVFV 379



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 40/126 (31%), Positives = 66/126 (52%), Gaps = 5/126 (3%)

Query: 754 QLGEIQLTVRYVCLRRCLSVLINGCRNLTPCTSSG-ADPYVRVYLLPERKWACRKKTSVK 812
           +LG++Q ++ Y      L V I     L      G +DPYV+V+LLP++K   + +T V 
Sbjct: 142 KLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKK--KFETKVH 199

Query: 813 RKTLEPLFDETFEFFVPMEEVKKRSLDVAVKNSRPLGSHRRKELGKVLIDLSKEDLIKGF 872
           RKTL P+F+E F F VP  E+  ++L +AV +      H    +G+  + ++  D     
Sbjct: 200 RKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKH--DIIGEFKVPMNTVDFGHVT 257

Query: 873 SQWYEL 878
            +W +L
Sbjct: 258 EEWRDL 263



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 32/104 (30%), Positives = 53/104 (50%), Gaps = 10/104 (9%)

Query: 310 VHLLEAEQLAQKDNFLGLRGKSDPYAKVSI---GLQHFRSRTIYRNLNPTWNEVFEFMV- 365
           V +++A +L   D    + G SDPY KV +     + F ++   + LNP +NE F F V 
Sbjct: 161 VGIIQAAELPALD----MGGTSDPYVKVFLLPDKKKKFETKVHRKTLNPVFNEQFTFKVP 216

Query: 366 -YEVPGQDLEVDLYDEDT-DRDDFLGSLQICLGDVMTNRVVDEW 407
             E+ G+ L + +YD D   + D +G  ++ +  V    V +EW
Sbjct: 217 YSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTEEW 260


>gi|5032139 synaptotagmin I [Homo sapiens]
          Length = 422

 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 38/111 (34%), Positives = 67/111 (60%), Gaps = 3/111 (2%)

Query: 752 RRQLGEIQLTVRYVCLRRCLSVLINGCRNLTPCTSSG-ADPYVRVYLLPERKWACRKKTS 810
           + +LG+I  ++RYV     L+V+I   +NL      G +DPYV+++L+   K   +KKT+
Sbjct: 271 QEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTT 330

Query: 811 VKRKTLEPLFDETFEFFVPMEEVKKRSLDVAVKNSRPLGSHRRKELGKVLI 861
           +K+ TL P ++E+F F VP E+++K  + V V +   +G  +   +GKV +
Sbjct: 331 IKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIG--KNDAIGKVFV 379



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 40/126 (31%), Positives = 66/126 (52%), Gaps = 5/126 (3%)

Query: 754 QLGEIQLTVRYVCLRRCLSVLINGCRNLTPCTSSG-ADPYVRVYLLPERKWACRKKTSVK 812
           +LG++Q ++ Y      L V I     L      G +DPYV+V+LLP++K   + +T V 
Sbjct: 142 KLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKK--KFETKVH 199

Query: 813 RKTLEPLFDETFEFFVPMEEVKKRSLDVAVKNSRPLGSHRRKELGKVLIDLSKEDLIKGF 872
           RKTL P+F+E F F VP  E+  ++L +AV +      H    +G+  + ++  D     
Sbjct: 200 RKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKH--DIIGEFKVPMNTVDFGHVT 257

Query: 873 SQWYEL 878
            +W +L
Sbjct: 258 EEWRDL 263



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 32/104 (30%), Positives = 53/104 (50%), Gaps = 10/104 (9%)

Query: 310 VHLLEAEQLAQKDNFLGLRGKSDPYAKVSI---GLQHFRSRTIYRNLNPTWNEVFEFMV- 365
           V +++A +L   D    + G SDPY KV +     + F ++   + LNP +NE F F V 
Sbjct: 161 VGIIQAAELPALD----MGGTSDPYVKVFLLPDKKKKFETKVHRKTLNPVFNEQFTFKVP 216

Query: 366 -YEVPGQDLEVDLYDEDT-DRDDFLGSLQICLGDVMTNRVVDEW 407
             E+ G+ L + +YD D   + D +G  ++ +  V    V +EW
Sbjct: 217 YSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTEEW 260


>gi|209447070 synaptotagmin I [Homo sapiens]
          Length = 422

 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 38/111 (34%), Positives = 67/111 (60%), Gaps = 3/111 (2%)

Query: 752 RRQLGEIQLTVRYVCLRRCLSVLINGCRNLTPCTSSG-ADPYVRVYLLPERKWACRKKTS 810
           + +LG+I  ++RYV     L+V+I   +NL      G +DPYV+++L+   K   +KKT+
Sbjct: 271 QEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTT 330

Query: 811 VKRKTLEPLFDETFEFFVPMEEVKKRSLDVAVKNSRPLGSHRRKELGKVLI 861
           +K+ TL P ++E+F F VP E+++K  + V V +   +G  +   +GKV +
Sbjct: 331 IKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIG--KNDAIGKVFV 379



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 40/126 (31%), Positives = 66/126 (52%), Gaps = 5/126 (3%)

Query: 754 QLGEIQLTVRYVCLRRCLSVLINGCRNLTPCTSSG-ADPYVRVYLLPERKWACRKKTSVK 812
           +LG++Q ++ Y      L V I     L      G +DPYV+V+LLP++K   + +T V 
Sbjct: 142 KLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKK--KFETKVH 199

Query: 813 RKTLEPLFDETFEFFVPMEEVKKRSLDVAVKNSRPLGSHRRKELGKVLIDLSKEDLIKGF 872
           RKTL P+F+E F F VP  E+  ++L +AV +      H    +G+  + ++  D     
Sbjct: 200 RKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKH--DIIGEFKVPMNTVDFGHVT 257

Query: 873 SQWYEL 878
            +W +L
Sbjct: 258 EEWRDL 263



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 32/104 (30%), Positives = 53/104 (50%), Gaps = 10/104 (9%)

Query: 310 VHLLEAEQLAQKDNFLGLRGKSDPYAKVSI---GLQHFRSRTIYRNLNPTWNEVFEFMV- 365
           V +++A +L   D    + G SDPY KV +     + F ++   + LNP +NE F F V 
Sbjct: 161 VGIIQAAELPALD----MGGTSDPYVKVFLLPDKKKKFETKVHRKTLNPVFNEQFTFKVP 216

Query: 366 -YEVPGQDLEVDLYDEDT-DRDDFLGSLQICLGDVMTNRVVDEW 407
             E+ G+ L + +YD D   + D +G  ++ +  V    V +EW
Sbjct: 217 YSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTEEW 260


>gi|227496504 multiple C2 domains, transmembrane 2 isoform 3 [Homo
           sapiens]
          Length = 306

 Score = 67.8 bits (164), Expect = 4e-11
 Identities = 36/91 (39%), Positives = 56/91 (61%), Gaps = 6/91 (6%)

Query: 306 GVIRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSIGLQHFRSRTIYRNLNPTWNEVFEFMV 365
           G+++V +L+A  L   D      GKSDP+  + +G    ++ T+Y+NLNP WN+VF F +
Sbjct: 97  GILQVKVLKAADLLAAD----FSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPI 152

Query: 366 YEVPGQDLEVDLYDEDTDR-DDFLGSLQICL 395
            ++    LEV ++DED D+  DFLG + I L
Sbjct: 153 KDI-HDVLEVTVFDEDGDKPPDFLGKVAIPL 182


>gi|28376627 synaptotagmin IX [Homo sapiens]
          Length = 491

 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 43/120 (35%), Positives = 66/120 (55%), Gaps = 5/120 (4%)

Query: 744 NIEGGDLRRRQLGEIQLTVRYVCLRRCLSVLINGCRNLTPCTSSG-ADPYVRVYLLPERK 802
           N +G     +  G++   ++Y C    L V I+   NL     SG +DPYV++YLLP+RK
Sbjct: 210 NDDGRRSNSKACGKLNFILKYDCDLEQLIVKIHKAVNLPAKDFSGTSDPYVKIYLLPDRK 269

Query: 803 WACRKKTSVKRKTLEPLFDETFEFFVPMEEVKKRSLDVAVKNSRPLGSHRRKELGKVLID 862
              + +T V RKTL P+FDE F F VP  +++ R L  +V +      H    +G+V++D
Sbjct: 270 --TKHQTKVHRKTLNPVFDEVFLFPVPYNDLEARKLHFSVYDFDRFSRH--DLIGQVVVD 325



 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 34/96 (35%), Positives = 55/96 (57%), Gaps = 1/96 (1%)

Query: 755 LGEIQLTVRYVCLRRCLSVLINGCRNLTPCTSSGA-DPYVRVYLLPERKWACRKKTSVKR 813
           LGE+  ++ Y+     L++ I   RNL     +GA DPYV+V L+ + +   ++KTS KR
Sbjct: 353 LGELMFSLCYLPTAGRLTITIIKARNLKAMDITGASDPYVKVSLMCDGRRLKKRKTSTKR 412

Query: 814 KTLEPLFDETFEFFVPMEEVKKRSLDVAVKNSRPLG 849
            TL P+++E   F VP E + +  L +AV +   +G
Sbjct: 413 NTLNPVYNEAIVFDVPPENIDQIHLSIAVMDYDRVG 448



 Score = 37.0 bits (84), Expect = 0.081
 Identities = 65/263 (24%), Positives = 108/263 (41%), Gaps = 61/263 (23%)

Query: 307 VIRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSI----GLQHFRSRTIYRNLNPTWNEVFE 362
           ++++H  +A  L  KD      G SDPY K+ +      +H +++   + LNP ++EVF 
Sbjct: 238 IVKIH--KAVNLPAKD----FSGTSDPYVKIYLLPDRKTKH-QTKVHRKTLNPVFDEVF- 289

Query: 363 FMVYEVPGQDLEV-----DLYDEDT-DRDDFLGSLQICLGDVMTNRVVDEWFVLNDTTSG 416
             ++ VP  DLE       +YD D   R D +G +           VVD +  L D    
Sbjct: 290 --LFPVPYNDLEARKLHFSVYDFDRFSRHDLIGQV-----------VVDHFLDLADFPRE 336

Query: 417 RLHLRLEWLSLLTDQEVLTEDHGGLSTAILVVFLESACNLPRNPFDYLNGEYRAKKLSRF 476
            +        L  D E +T D+  L   +      S C LP        G      +   
Sbjct: 337 CI--------LWKDIEYVTNDNVDLGELMF-----SLCYLP------TAGRLTITIIK-- 375

Query: 477 ARNKVSKD----PSSYVKLSV---GKKTHTSKTCP--HNKDPVWSQVFSFFVHNVATERL 527
           ARN  + D       YVK+S+   G++    KT    +  +PV+++   F V     +++
Sbjct: 376 ARNLKAMDITGASDPYVKVSLMCDGRRLKKRKTSTKRNTLNPVYNEAIVFDVPPENIDQI 435

Query: 528 HLKVLDDDQECALGMLEVPLCQI 550
           HL +   D +       + +CQ+
Sbjct: 436 HLSIAVMDYDRVGHNEIIGVCQV 458



 Score = 36.6 bits (83), Expect = 0.11
 Identities = 27/90 (30%), Positives = 46/90 (51%), Gaps = 16/90 (17%)

Query: 294 LDLTNLRFPL----PCGVIRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSI-----GLQHF 344
           +DL  L F L      G + + +++A  L   D    + G SDPY KVS+      L+  
Sbjct: 351 VDLGELMFSLCYLPTAGRLTITIIKARNLKAMD----ITGASDPYVKVSLMCDGRRLKKR 406

Query: 345 RSRTIYRNLNPTWNEVFEFMVYEVPGQDLE 374
           ++ T    LNP +NE    +V++VP ++++
Sbjct: 407 KTSTKRNTLNPVYNEA---IVFDVPPENID 433


>gi|38570146 synaptotagmin VII [Homo sapiens]
          Length = 403

 Score = 67.0 bits (162), Expect = 7e-11
 Identities = 56/156 (35%), Positives = 82/156 (52%), Gaps = 7/156 (4%)

Query: 728 LNSLASSCFDLADISLNIEGGD-LRRRQLGEIQLTVRYVCLRRCLSVLINGCRNLTPCTS 786
           +NSL S    L+  S   E  +   R  LG IQ +V Y      L+V I   + L     
Sbjct: 108 VNSLTSEMLMLSPGSEEDEAHEGCSRENLGRIQFSVGYNFQESTLTVKIMKAQELPAKDF 167

Query: 787 SG-ADPYVRVYLLPERKWACRKKTSVKRKTLEPLFDETFEF-FVPMEEVKKRSLDVAVKN 844
           SG +DP+V++YLLP++K   + +T VKRK L P ++ETF F   P E+V +R L + V +
Sbjct: 168 SGTSDPFVKIYLLPDKKH--KLETKVKRKNLNPHWNETFLFEGFPYEKVVQRILYLQVLD 225

Query: 845 SRPLGSHRRKELGKVLIDLSKEDLIKGFSQWYELTP 880
                  R   +G+V I L+K DL +  + W +L P
Sbjct: 226 YDRFS--RNDPIGEVSIPLNKVDLTQMQTFWKDLKP 259



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 33/107 (30%), Positives = 60/107 (56%), Gaps = 3/107 (2%)

Query: 756 GEIQLTVRYVCLRRCLSVLINGCRNLTPCTSSG-ADPYVRVYLLPERKWACRKKTSVKRK 814
           GE+ L++ Y      + V I   RNL      G +DPYV+V+L+ + K   +KKT   ++
Sbjct: 268 GELLLSLCYNPSANSIIVNIIKARNLKAMDIGGTSDPYVKVWLMYKDKRVEKKKTVTMKR 327

Query: 815 TLEPLFDETFEFFVPMEEVKKRSLDVAVKNSRPLGSHRRKELGKVLI 861
            L P+F+E+F F +P E++++ ++ + V +   L   R   +GK+ +
Sbjct: 328 NLNPIFNESFAFDIPTEKLRETTIIITVMDKDKLS--RNDVIGKIYL 372



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 59/241 (24%), Positives = 101/241 (41%), Gaps = 44/241 (18%)

Query: 308 IRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSI---GLQHFRSRTIYRNLNPTWNEVFEFM 364
           + V +++A++L  KD      G SDP+ K+ +         ++   +NLNP WNE F F 
Sbjct: 152 LTVKIMKAQELPAKD----FSGTSDPFVKIYLLPDKKHKLETKVKRKNLNPHWNETFLFE 207

Query: 365 VY---EVPGQDLEVDLYDEDT-DRDDFLGSLQICLGDVMTNRVVDEWFVLNDTTSGRLHL 420
            +   +V  + L + + D D   R+D +G + I L  V   ++   W  L   + G    
Sbjct: 208 GFPYEKVVQRILYLQVLDYDRFSRNDPIGEVSIPLNKVDLTQMQTFWKDLKPCSDGSGSR 267

Query: 421 RLEWLSLLTDQEVLTEDHGGLSTAILVVFLESACNLPRNPFDYLNGEYRAKKLSRFARNK 480
               LSL  +           S   ++V +  A NL        +  Y  K    +   +
Sbjct: 268 GELLLSLCYNP----------SANSIIVNIIKARNLKAMDIGGTSDPY-VKVWLMYKDKR 316

Query: 481 VSKDPSSYVKLSVGKKTHTSKTCPHNKDPVWSQVFSFFVHNVATERLH-----LKVLDDD 535
           V K           KKT T K    N +P++++ F+F   ++ TE+L      + V+D D
Sbjct: 317 VEK-----------KKTVTMK---RNLNPIFNESFAF---DIPTEKLRETTIIITVMDKD 359

Query: 536 Q 536
           +
Sbjct: 360 K 360



 Score = 38.1 bits (87), Expect = 0.036
 Identities = 32/113 (28%), Positives = 57/113 (50%), Gaps = 18/113 (15%)

Query: 292 KGLDLTNLRFPLPCGVIRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSI-----GLQHFRS 346
           +G  L +L +      I V++++A  L   D    + G SDPY KV +      ++  ++
Sbjct: 267 RGELLLSLCYNPSANSIIVNIIKARNLKAMD----IGGTSDPYVKVWLMYKDKRVEKKKT 322

Query: 347 RTIYRNLNPTWNEVFEFMVYEVPGQDLE-----VDLYDED-TDRDDFLGSLQI 393
            T+ RNLNP +NE F F   ++P + L      + + D+D   R+D +G + +
Sbjct: 323 VTMKRNLNPIFNESFAF---DIPTEKLRETTIIITVMDKDKLSRNDVIGKIYL 372


>gi|15011900 synaptotagmin-like 2 isoform b [Homo sapiens]
          Length = 376

 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 49/165 (29%), Positives = 86/165 (52%), Gaps = 10/165 (6%)

Query: 711 ASPFAWPPKRLAPSMSSLNSLASSC--FDLADIS---LNIEGGDLRRRQL-GEIQLTVRY 764
           AS  ++   R   S SSL +L+SS     L+ +S   +++  GD    ++ G IQ  + Y
Sbjct: 21  ASESSYQLSRHKKSPSSLTNLSSSSGMTSLSSVSGSVMSVYSGDFGNLEVKGNIQFAIEY 80

Query: 765 VCLRRCLSVLINGCRNLTPCT--SSGADPYVRVYLLPERKWACRKKTSVKRKTLEPLFDE 822
           V   + L V +  C++L         +DPYV+ YLLP++    +KKT V +KTL P+++E
Sbjct: 81  VESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNE 140

Query: 823 TFEFFVPMEEVKKRSLDVAVKNSRPLGSHRRKELGKVLIDLSKED 867
              + +  + +K + L++++ +       R   LG+V +DL   D
Sbjct: 141 ILRYKIEKQILKTQKLNLSIWHRDTF--KRNSFLGEVELDLETWD 183



 Score = 33.1 bits (74), Expect = 1.2
 Identities = 23/96 (23%), Positives = 48/96 (50%), Gaps = 11/96 (11%)

Query: 308 IRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSI-----GLQHFRSRTIYRNLNPTWNEVFE 362
           + V + + + LA  D     + +SDPY K  +      +   ++  + + LNP +NE+  
Sbjct: 87  LHVFVAQCKDLAAADV---KKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILR 143

Query: 363 FMVYE--VPGQDLEVDLYDEDT-DRDDFLGSLQICL 395
           + + +  +  Q L + ++  DT  R+ FLG +++ L
Sbjct: 144 YKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDL 179



 Score = 30.0 bits (66), Expect = 9.9
 Identities = 14/54 (25%), Positives = 26/54 (48%)

Query: 773 VLINGCRNLTPCTSSGADPYVRVYLLPERKWACRKKTSVKRKTLEPLFDETFEF 826
           + +  C +L     S  + +V+  +LP+     R+KT    KT  P+F+ T  +
Sbjct: 238 IWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVY 291


>gi|244790020 synaptotagmin-like 2 isoform i [Homo sapiens]
          Length = 935

 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 49/165 (29%), Positives = 86/165 (52%), Gaps = 10/165 (6%)

Query: 711 ASPFAWPPKRLAPSMSSLNSLASSC--FDLADIS---LNIEGGDLRRRQL-GEIQLTVRY 764
           AS  ++   R   S SSL +L+SS     L+ +S   +++  GD    ++ G IQ  + Y
Sbjct: 580 ASESSYQLSRHKKSPSSLTNLSSSSGMTSLSSVSGSVMSVYSGDFGNLEVKGNIQFAIEY 639

Query: 765 VCLRRCLSVLINGCRNLTPCT--SSGADPYVRVYLLPERKWACRKKTSVKRKTLEPLFDE 822
           V   + L V +  C++L         +DPYV+ YLLP++    +KKT V +KTL P+++E
Sbjct: 640 VESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNE 699

Query: 823 TFEFFVPMEEVKKRSLDVAVKNSRPLGSHRRKELGKVLIDLSKED 867
              + +  + +K + L++++ +       R   LG+V +DL   D
Sbjct: 700 ILRYKIEKQILKTQKLNLSIWHRDTF--KRNSFLGEVELDLETWD 742



 Score = 33.1 bits (74), Expect = 1.2
 Identities = 23/96 (23%), Positives = 48/96 (50%), Gaps = 11/96 (11%)

Query: 308 IRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSI-----GLQHFRSRTIYRNLNPTWNEVFE 362
           + V + + + LA  D     + +SDPY K  +      +   ++  + + LNP +NE+  
Sbjct: 646 LHVFVAQCKDLAAADV---KKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILR 702

Query: 363 FMVYE--VPGQDLEVDLYDEDT-DRDDFLGSLQICL 395
           + + +  +  Q L + ++  DT  R+ FLG +++ L
Sbjct: 703 YKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDL 738



 Score = 30.0 bits (66), Expect = 9.9
 Identities = 14/54 (25%), Positives = 26/54 (48%)

Query: 773 VLINGCRNLTPCTSSGADPYVRVYLLPERKWACRKKTSVKRKTLEPLFDETFEF 826
           + +  C +L     S  + +V+  +LP+     R+KT    KT  P+F+ T  +
Sbjct: 797 IWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVY 850


>gi|244790013 synaptotagmin-like 2 isoform g [Homo sapiens]
          Length = 934

 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 49/165 (29%), Positives = 86/165 (52%), Gaps = 10/165 (6%)

Query: 711 ASPFAWPPKRLAPSMSSLNSLASSC--FDLADIS---LNIEGGDLRRRQL-GEIQLTVRY 764
           AS  ++   R   S SSL +L+SS     L+ +S   +++  GD    ++ G IQ  + Y
Sbjct: 579 ASESSYQLSRHKKSPSSLTNLSSSSGMTSLSSVSGSVMSVYSGDFGNLEVKGNIQFAIEY 638

Query: 765 VCLRRCLSVLINGCRNLTPCT--SSGADPYVRVYLLPERKWACRKKTSVKRKTLEPLFDE 822
           V   + L V +  C++L         +DPYV+ YLLP++    +KKT V +KTL P+++E
Sbjct: 639 VESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNE 698

Query: 823 TFEFFVPMEEVKKRSLDVAVKNSRPLGSHRRKELGKVLIDLSKED 867
              + +  + +K + L++++ +       R   LG+V +DL   D
Sbjct: 699 ILRYKIEKQILKTQKLNLSIWHRDTF--KRNSFLGEVELDLETWD 741



 Score = 33.1 bits (74), Expect = 1.2
 Identities = 23/96 (23%), Positives = 48/96 (50%), Gaps = 11/96 (11%)

Query: 308 IRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSI-----GLQHFRSRTIYRNLNPTWNEVFE 362
           + V + + + LA  D     + +SDPY K  +      +   ++  + + LNP +NE+  
Sbjct: 645 LHVFVAQCKDLAAADV---KKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILR 701

Query: 363 FMVYE--VPGQDLEVDLYDEDT-DRDDFLGSLQICL 395
           + + +  +  Q L + ++  DT  R+ FLG +++ L
Sbjct: 702 YKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDL 737



 Score = 30.0 bits (66), Expect = 9.9
 Identities = 14/54 (25%), Positives = 26/54 (48%)

Query: 773 VLINGCRNLTPCTSSGADPYVRVYLLPERKWACRKKTSVKRKTLEPLFDETFEF 826
           + +  C +L     S  + +V+  +LP+     R+KT    KT  P+F+ T  +
Sbjct: 796 IWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVY 849


>gi|46255068 synaptotagmin-like 2 isoform f [Homo sapiens]
          Length = 365

 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 49/165 (29%), Positives = 86/165 (52%), Gaps = 10/165 (6%)

Query: 711 ASPFAWPPKRLAPSMSSLNSLASSC--FDLADIS---LNIEGGDLRRRQL-GEIQLTVRY 764
           AS  ++   R   S SSL +L+SS     L+ +S   +++  GD    ++ G IQ  + Y
Sbjct: 10  ASESSYQLSRHKKSPSSLTNLSSSSGMTSLSSVSGSVMSVYSGDFGNLEVKGNIQFAIEY 69

Query: 765 VCLRRCLSVLINGCRNLTPCT--SSGADPYVRVYLLPERKWACRKKTSVKRKTLEPLFDE 822
           V   + L V +  C++L         +DPYV+ YLLP++    +KKT V +KTL P+++E
Sbjct: 70  VESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNE 129

Query: 823 TFEFFVPMEEVKKRSLDVAVKNSRPLGSHRRKELGKVLIDLSKED 867
              + +  + +K + L++++ +       R   LG+V +DL   D
Sbjct: 130 ILRYKIEKQILKTQKLNLSIWHRDTF--KRNSFLGEVELDLETWD 172



 Score = 33.1 bits (74), Expect = 1.2
 Identities = 23/96 (23%), Positives = 48/96 (50%), Gaps = 11/96 (11%)

Query: 308 IRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSI-----GLQHFRSRTIYRNLNPTWNEVFE 362
           + V + + + LA  D     + +SDPY K  +      +   ++  + + LNP +NE+  
Sbjct: 76  LHVFVAQCKDLAAADV---KKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILR 132

Query: 363 FMVYE--VPGQDLEVDLYDEDT-DRDDFLGSLQICL 395
           + + +  +  Q L + ++  DT  R+ FLG +++ L
Sbjct: 133 YKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDL 168



 Score = 30.0 bits (66), Expect = 9.9
 Identities = 14/54 (25%), Positives = 26/54 (48%)

Query: 773 VLINGCRNLTPCTSSGADPYVRVYLLPERKWACRKKTSVKRKTLEPLFDETFEF 826
           + +  C +L     S  + +V+  +LP+     R+KT    KT  P+F+ T  +
Sbjct: 227 IWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVY 280


>gi|46255066 synaptotagmin-like 2 isoform e [Homo sapiens]
          Length = 376

 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 49/165 (29%), Positives = 86/165 (52%), Gaps = 10/165 (6%)

Query: 711 ASPFAWPPKRLAPSMSSLNSLASSC--FDLADIS---LNIEGGDLRRRQL-GEIQLTVRY 764
           AS  ++   R   S SSL +L+SS     L+ +S   +++  GD    ++ G IQ  + Y
Sbjct: 21  ASESSYQLSRHKKSPSSLTNLSSSSGMTSLSSVSGSVMSVYSGDFGNLEVKGNIQFAIEY 80

Query: 765 VCLRRCLSVLINGCRNLTPCT--SSGADPYVRVYLLPERKWACRKKTSVKRKTLEPLFDE 822
           V   + L V +  C++L         +DPYV+ YLLP++    +KKT V +KTL P+++E
Sbjct: 81  VESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNE 140

Query: 823 TFEFFVPMEEVKKRSLDVAVKNSRPLGSHRRKELGKVLIDLSKED 867
              + +  + +K + L++++ +       R   LG+V +DL   D
Sbjct: 141 ILRYKIEKQILKTQKLNLSIWHRDTF--KRNSFLGEVELDLETWD 183



 Score = 33.1 bits (74), Expect = 1.2
 Identities = 23/96 (23%), Positives = 48/96 (50%), Gaps = 11/96 (11%)

Query: 308 IRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSI-----GLQHFRSRTIYRNLNPTWNEVFE 362
           + V + + + LA  D     + +SDPY K  +      +   ++  + + LNP +NE+  
Sbjct: 87  LHVFVAQCKDLAAADV---KKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILR 143

Query: 363 FMVYE--VPGQDLEVDLYDEDT-DRDDFLGSLQICL 395
           + + +  +  Q L + ++  DT  R+ FLG +++ L
Sbjct: 144 YKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDL 179



 Score = 30.0 bits (66), Expect = 9.9
 Identities = 14/54 (25%), Positives = 26/54 (48%)

Query: 773 VLINGCRNLTPCTSSGADPYVRVYLLPERKWACRKKTSVKRKTLEPLFDETFEF 826
           + +  C +L     S  + +V+  +LP+     R+KT    KT  P+F+ T  +
Sbjct: 238 IWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVY 291


>gi|46255064 synaptotagmin-like 2 isoform d [Homo sapiens]
          Length = 1256

 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 49/165 (29%), Positives = 86/165 (52%), Gaps = 10/165 (6%)

Query: 711  ASPFAWPPKRLAPSMSSLNSLASSC--FDLADIS---LNIEGGDLRRRQL-GEIQLTVRY 764
            AS  ++   R   S SSL +L+SS     L+ +S   +++  GD    ++ G IQ  + Y
Sbjct: 901  ASESSYQLSRHKKSPSSLTNLSSSSGMTSLSSVSGSVMSVYSGDFGNLEVKGNIQFAIEY 960

Query: 765  VCLRRCLSVLINGCRNLTPCT--SSGADPYVRVYLLPERKWACRKKTSVKRKTLEPLFDE 822
            V   + L V +  C++L         +DPYV+ YLLP++    +KKT V +KTL P+++E
Sbjct: 961  VESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNE 1020

Query: 823  TFEFFVPMEEVKKRSLDVAVKNSRPLGSHRRKELGKVLIDLSKED 867
               + +  + +K + L++++ +       R   LG+V +DL   D
Sbjct: 1021 ILRYKIEKQILKTQKLNLSIWHRDTF--KRNSFLGEVELDLETWD 1063



 Score = 33.1 bits (74), Expect = 1.2
 Identities = 23/96 (23%), Positives = 48/96 (50%), Gaps = 11/96 (11%)

Query: 308  IRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSI-----GLQHFRSRTIYRNLNPTWNEVFE 362
            + V + + + LA  D     + +SDPY K  +      +   ++  + + LNP +NE+  
Sbjct: 967  LHVFVAQCKDLAAADV---KKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILR 1023

Query: 363  FMVYE--VPGQDLEVDLYDEDT-DRDDFLGSLQICL 395
            + + +  +  Q L + ++  DT  R+ FLG +++ L
Sbjct: 1024 YKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDL 1059



 Score = 30.0 bits (66), Expect = 9.9
 Identities = 14/54 (25%), Positives = 26/54 (48%)

Query: 773  VLINGCRNLTPCTSSGADPYVRVYLLPERKWACRKKTSVKRKTLEPLFDETFEF 826
            + +  C +L     S  + +V+  +LP+     R+KT    KT  P+F+ T  +
Sbjct: 1118 IWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVY 1171


>gi|46255062 synaptotagmin-like 2 isoform c [Homo sapiens]
          Length = 1272

 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 49/165 (29%), Positives = 86/165 (52%), Gaps = 10/165 (6%)

Query: 711  ASPFAWPPKRLAPSMSSLNSLASSC--FDLADIS---LNIEGGDLRRRQL-GEIQLTVRY 764
            AS  ++   R   S SSL +L+SS     L+ +S   +++  GD    ++ G IQ  + Y
Sbjct: 917  ASESSYQLSRHKKSPSSLTNLSSSSGMTSLSSVSGSVMSVYSGDFGNLEVKGNIQFAIEY 976

Query: 765  VCLRRCLSVLINGCRNLTPCT--SSGADPYVRVYLLPERKWACRKKTSVKRKTLEPLFDE 822
            V   + L V +  C++L         +DPYV+ YLLP++    +KKT V +KTL P+++E
Sbjct: 977  VESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNE 1036

Query: 823  TFEFFVPMEEVKKRSLDVAVKNSRPLGSHRRKELGKVLIDLSKED 867
               + +  + +K + L++++ +       R   LG+V +DL   D
Sbjct: 1037 ILRYKIEKQILKTQKLNLSIWHRDTF--KRNSFLGEVELDLETWD 1079



 Score = 33.1 bits (74), Expect = 1.2
 Identities = 23/96 (23%), Positives = 48/96 (50%), Gaps = 11/96 (11%)

Query: 308  IRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSI-----GLQHFRSRTIYRNLNPTWNEVFE 362
            + V + + + LA  D     + +SDPY K  +      +   ++  + + LNP +NE+  
Sbjct: 983  LHVFVAQCKDLAAADV---KKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILR 1039

Query: 363  FMVYE--VPGQDLEVDLYDEDT-DRDDFLGSLQICL 395
            + + +  +  Q L + ++  DT  R+ FLG +++ L
Sbjct: 1040 YKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDL 1075



 Score = 30.0 bits (66), Expect = 9.9
 Identities = 14/54 (25%), Positives = 26/54 (48%)

Query: 773  VLINGCRNLTPCTSSGADPYVRVYLLPERKWACRKKTSVKRKTLEPLFDETFEF 826
            + +  C +L     S  + +V+  +LP+     R+KT    KT  P+F+ T  +
Sbjct: 1134 IWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVY 1187


>gi|238550198 synaptotagmin III [Homo sapiens]
          Length = 590

 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 42/108 (38%), Positives = 64/108 (59%), Gaps = 5/108 (4%)

Query: 756 GEIQLTVRYVCLRRCLSVLINGCRNLTPCTSSG-ADPYVRVYLLPERKWACRKKTSVKRK 814
           G I   +RY+     L V I    +L    S+G +DPYV++YLLP+RK   + +T V RK
Sbjct: 301 GRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKK--KFQTKVHRK 358

Query: 815 TLEPLFDETFEFFVPMEEVKKRSLDVAVKNSRPLGSHRRKELGKVLID 862
           TL P+F+ETF+F VP+ E+ +R L  +V +      H    +G+V++D
Sbjct: 359 TLNPVFNETFQFSVPLAELAQRKLHFSVYDFDRFSRH--DLIGQVVLD 404



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 41/138 (29%), Positives = 68/138 (49%), Gaps = 5/138 (3%)

Query: 745 IEGGDLRRRQLGEIQLTVRYVCLRRCLSVLINGCRNLTPCTSSG-ADPYVRVYLLPERKW 803
           +EGG   +  LGE+  ++ Y+     L+V I    NL     +G +DPYV+  L+ E + 
Sbjct: 423 VEGGS-EKADLGELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRR 481

Query: 804 ACRKKTSVKRKTLEPLFDETFEFFVPMEEVKKRSLDVAVKNSRPLGSHRRKELGKVLIDL 863
             ++KTS+K+ TL P ++E   F V  E V+   L +AV +   +G +    + +V  D 
Sbjct: 482 LKKRKTSIKKNTLNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGHNEVIGVCRVGPDA 541

Query: 864 SKEDLIKGFSQWYELTPN 881
           +      G   W E+  N
Sbjct: 542 ADP---HGREHWAEMLAN 556



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 31/99 (31%), Positives = 50/99 (50%), Gaps = 10/99 (10%)

Query: 299 LRFPLPCGVIRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSI---GLQHFRSRTIYRNLNP 355
           LR+      + V +L+A  L  KD+     G SDPY K+ +     + F+++   + LNP
Sbjct: 307 LRYLYGSDQLVVRILQALDLPAKDS----NGFSDPYVKIYLLPDRKKKFQTKVHRKTLNP 362

Query: 356 TWNEVFEFMV--YEVPGQDLEVDLYDEDT-DRDDFLGSL 391
            +NE F+F V   E+  + L   +YD D   R D +G +
Sbjct: 363 VFNETFQFSVPLAELAQRKLHFSVYDFDRFSRHDLIGQV 401



 Score = 33.9 bits (76), Expect = 0.69
 Identities = 33/98 (33%), Positives = 45/98 (45%), Gaps = 15/98 (15%)

Query: 295 DLTNLRFPL----PCGVIRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSIGLQ----HFRS 346
           DL  L F L      G + V +++A  L   D    L G SDPY K S+  +      R 
Sbjct: 431 DLGELNFSLCYLPTAGRLTVTIIKASNLKAMD----LTGFSDPYVKASLISEGRRLKKRK 486

Query: 347 RTIYRN-LNPTWNE--VFEFMVYEVPGQDLEVDLYDED 381
            +I +N LNPT+NE  VF+     V    L + + D D
Sbjct: 487 TSIKKNTLNPTYNEALVFDVAPESVENVGLSIAVVDYD 524


>gi|238550196 synaptotagmin III [Homo sapiens]
          Length = 590

 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 42/108 (38%), Positives = 64/108 (59%), Gaps = 5/108 (4%)

Query: 756 GEIQLTVRYVCLRRCLSVLINGCRNLTPCTSSG-ADPYVRVYLLPERKWACRKKTSVKRK 814
           G I   +RY+     L V I    +L    S+G +DPYV++YLLP+RK   + +T V RK
Sbjct: 301 GRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKK--KFQTKVHRK 358

Query: 815 TLEPLFDETFEFFVPMEEVKKRSLDVAVKNSRPLGSHRRKELGKVLID 862
           TL P+F+ETF+F VP+ E+ +R L  +V +      H    +G+V++D
Sbjct: 359 TLNPVFNETFQFSVPLAELAQRKLHFSVYDFDRFSRH--DLIGQVVLD 404



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 41/138 (29%), Positives = 68/138 (49%), Gaps = 5/138 (3%)

Query: 745 IEGGDLRRRQLGEIQLTVRYVCLRRCLSVLINGCRNLTPCTSSG-ADPYVRVYLLPERKW 803
           +EGG   +  LGE+  ++ Y+     L+V I    NL     +G +DPYV+  L+ E + 
Sbjct: 423 VEGGS-EKADLGELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRR 481

Query: 804 ACRKKTSVKRKTLEPLFDETFEFFVPMEEVKKRSLDVAVKNSRPLGSHRRKELGKVLIDL 863
             ++KTS+K+ TL P ++E   F V  E V+   L +AV +   +G +    + +V  D 
Sbjct: 482 LKKRKTSIKKNTLNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGHNEVIGVCRVGPDA 541

Query: 864 SKEDLIKGFSQWYELTPN 881
           +      G   W E+  N
Sbjct: 542 ADP---HGREHWAEMLAN 556



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 31/99 (31%), Positives = 50/99 (50%), Gaps = 10/99 (10%)

Query: 299 LRFPLPCGVIRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSI---GLQHFRSRTIYRNLNP 355
           LR+      + V +L+A  L  KD+     G SDPY K+ +     + F+++   + LNP
Sbjct: 307 LRYLYGSDQLVVRILQALDLPAKDS----NGFSDPYVKIYLLPDRKKKFQTKVHRKTLNP 362

Query: 356 TWNEVFEFMV--YEVPGQDLEVDLYDEDT-DRDDFLGSL 391
            +NE F+F V   E+  + L   +YD D   R D +G +
Sbjct: 363 VFNETFQFSVPLAELAQRKLHFSVYDFDRFSRHDLIGQV 401



 Score = 33.9 bits (76), Expect = 0.69
 Identities = 33/98 (33%), Positives = 45/98 (45%), Gaps = 15/98 (15%)

Query: 295 DLTNLRFPL----PCGVIRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSIGLQ----HFRS 346
           DL  L F L      G + V +++A  L   D    L G SDPY K S+  +      R 
Sbjct: 431 DLGELNFSLCYLPTAGRLTVTIIKASNLKAMD----LTGFSDPYVKASLISEGRRLKKRK 486

Query: 347 RTIYRN-LNPTWNE--VFEFMVYEVPGQDLEVDLYDED 381
            +I +N LNPT+NE  VF+     V    L + + D D
Sbjct: 487 TSIKKNTLNPTYNEALVFDVAPESVENVGLSIAVVDYD 524


>gi|14150054 synaptotagmin III [Homo sapiens]
          Length = 590

 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 42/108 (38%), Positives = 64/108 (59%), Gaps = 5/108 (4%)

Query: 756 GEIQLTVRYVCLRRCLSVLINGCRNLTPCTSSG-ADPYVRVYLLPERKWACRKKTSVKRK 814
           G I   +RY+     L V I    +L    S+G +DPYV++YLLP+RK   + +T V RK
Sbjct: 301 GRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKK--KFQTKVHRK 358

Query: 815 TLEPLFDETFEFFVPMEEVKKRSLDVAVKNSRPLGSHRRKELGKVLID 862
           TL P+F+ETF+F VP+ E+ +R L  +V +      H    +G+V++D
Sbjct: 359 TLNPVFNETFQFSVPLAELAQRKLHFSVYDFDRFSRH--DLIGQVVLD 404



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 41/138 (29%), Positives = 68/138 (49%), Gaps = 5/138 (3%)

Query: 745 IEGGDLRRRQLGEIQLTVRYVCLRRCLSVLINGCRNLTPCTSSG-ADPYVRVYLLPERKW 803
           +EGG   +  LGE+  ++ Y+     L+V I    NL     +G +DPYV+  L+ E + 
Sbjct: 423 VEGGS-EKADLGELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRR 481

Query: 804 ACRKKTSVKRKTLEPLFDETFEFFVPMEEVKKRSLDVAVKNSRPLGSHRRKELGKVLIDL 863
             ++KTS+K+ TL P ++E   F V  E V+   L +AV +   +G +    + +V  D 
Sbjct: 482 LKKRKTSIKKNTLNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGHNEVIGVCRVGPDA 541

Query: 864 SKEDLIKGFSQWYELTPN 881
           +      G   W E+  N
Sbjct: 542 ADP---HGREHWAEMLAN 556



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 31/99 (31%), Positives = 50/99 (50%), Gaps = 10/99 (10%)

Query: 299 LRFPLPCGVIRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSI---GLQHFRSRTIYRNLNP 355
           LR+      + V +L+A  L  KD+     G SDPY K+ +     + F+++   + LNP
Sbjct: 307 LRYLYGSDQLVVRILQALDLPAKDS----NGFSDPYVKIYLLPDRKKKFQTKVHRKTLNP 362

Query: 356 TWNEVFEFMV--YEVPGQDLEVDLYDEDT-DRDDFLGSL 391
            +NE F+F V   E+  + L   +YD D   R D +G +
Sbjct: 363 VFNETFQFSVPLAELAQRKLHFSVYDFDRFSRHDLIGQV 401



 Score = 33.9 bits (76), Expect = 0.69
 Identities = 33/98 (33%), Positives = 45/98 (45%), Gaps = 15/98 (15%)

Query: 295 DLTNLRFPL----PCGVIRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSIGLQ----HFRS 346
           DL  L F L      G + V +++A  L   D    L G SDPY K S+  +      R 
Sbjct: 431 DLGELNFSLCYLPTAGRLTVTIIKASNLKAMD----LTGFSDPYVKASLISEGRRLKKRK 486

Query: 347 RTIYRN-LNPTWNE--VFEFMVYEVPGQDLEVDLYDED 381
            +I +N LNPT+NE  VF+     V    L + + D D
Sbjct: 487 TSIKKNTLNPTYNEALVFDVAPESVENVGLSIAVVDYD 524


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.137    0.422 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,690,203
Number of Sequences: 37866
Number of extensions: 1859928
Number of successful extensions: 10401
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 142
Number of HSP's successfully gapped in prelim test: 245
Number of HSP's that attempted gapping in prelim test: 8721
Number of HSP's gapped (non-prelim): 1637
length of query: 886
length of database: 18,247,518
effective HSP length: 111
effective length of query: 775
effective length of database: 14,044,392
effective search space: 10884403800
effective search space used: 10884403800
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.