Search of human proteins with 18375648

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|18375648 protein tyrosine phosphatase, non-receptor type 13
isoform 3 [Homo sapiens]
         (2294 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i...  4573   0.0  
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is...  2820   0.0  
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i...  2820   0.0  
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i...  2814   0.0  
gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo sa...   489   e-137
gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo sa...   489   e-137
gi|109138573 protein tyrosine phosphatase, non-receptor type 20A...   239   3e-62
gi|109138561 protein tyrosine phosphatase, non-receptor type 20A...   239   3e-62
gi|109138557 protein tyrosine phosphatase, non-receptor type 20A...   239   3e-62
gi|108802617 protein tyrosine phosphatase, non-receptor type 20 ...   239   3e-62
gi|108802607 protein tyrosine phosphatase, non-receptor type 20 ...   239   3e-62
gi|108802604 protein tyrosine phosphatase, non-receptor type 20 ...   239   3e-62
gi|108802611 protein tyrosine phosphatase, non-receptor type 20 ...   214   6e-55
gi|109138565 protein tyrosine phosphatase, non-receptor type 20A...   214   6e-55
gi|241896926 protein tyrosine phosphatase, receptor type, H isof...   194   1e-48
gi|241896924 protein tyrosine phosphatase, receptor type, H isof...   194   1e-48
gi|223941891 protein tyrosine phosphatase, non-receptor type 3 i...   190   2e-47
gi|223941888 protein tyrosine phosphatase, non-receptor type 3 i...   190   2e-47
gi|223941885 protein tyrosine phosphatase, non-receptor type 3 i...   190   2e-47
gi|223941882 protein tyrosine phosphatase, non-receptor type 3 i...   190   2e-47
gi|223941879 protein tyrosine phosphatase, non-receptor type 3 i...   190   2e-47
gi|223941876 protein tyrosine phosphatase, non-receptor type 3 i...   190   2e-47
gi|33356177 protein tyrosine phosphatase, non-receptor type 11 [...   189   3e-47
gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Ho...   186   2e-46
gi|109633041 protein tyrosine phosphatase, receptor type, F isof...   183   2e-45
gi|109633039 protein tyrosine phosphatase, receptor type, F isof...   183   2e-45
gi|208431815 protein tyrosine phosphatase, receptor type, K isof...   182   3e-45
gi|18104993 protein tyrosine phosphatase, non-receptor type 6 is...   182   3e-45
gi|18104989 protein tyrosine phosphatase, non-receptor type 6 is...   182   3e-45
gi|18104991 protein tyrosine phosphatase, non-receptor type 6 is...   182   3e-45

>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
            isoform 3 [Homo sapiens]
          Length = 2294

 Score = 4573 bits (11861), Expect = 0.0
 Identities = 2294/2294 (100%), Positives = 2294/2294 (100%)

Query: 1    MHVSLAEALEVRGGPLQEEEIWAVLNQSAESLQELFRKVSLADPAALGFIISPWSLLLLP 60
            MHVSLAEALEVRGGPLQEEEIWAVLNQSAESLQELFRKVSLADPAALGFIISPWSLLLLP
Sbjct: 1    MHVSLAEALEVRGGPLQEEEIWAVLNQSAESLQELFRKVSLADPAALGFIISPWSLLLLP 60

Query: 61   SGSVSFTDENISNQDLRAFTAPEVLQNQSLTSLSDVEKIHIYSLGMTLYWGADYEVPQSQ 120
            SGSVSFTDENISNQDLRAFTAPEVLQNQSLTSLSDVEKIHIYSLGMTLYWGADYEVPQSQ
Sbjct: 61   SGSVSFTDENISNQDLRAFTAPEVLQNQSLTSLSDVEKIHIYSLGMTLYWGADYEVPQSQ 120

Query: 121  PIKLGDHLNSILLGMCEDVIYARVSVRTVLDACSAHIRNSNCAPSFSYVKHLVKLVLGNL 180
            PIKLGDHLNSILLGMCEDVIYARVSVRTVLDACSAHIRNSNCAPSFSYVKHLVKLVLGNL
Sbjct: 121  PIKLGDHLNSILLGMCEDVIYARVSVRTVLDACSAHIRNSNCAPSFSYVKHLVKLVLGNL 180

Query: 181  SGTDQLSCNSEQKPDRSQAIRDRLRGKGLPTGRSSTSDVLDIQKPPLSHQTFLNKGLSKS 240
            SGTDQLSCNSEQKPDRSQAIRDRLRGKGLPTGRSSTSDVLDIQKPPLSHQTFLNKGLSKS
Sbjct: 181  SGTDQLSCNSEQKPDRSQAIRDRLRGKGLPTGRSSTSDVLDIQKPPLSHQTFLNKGLSKS 240

Query: 241  MGFLSIKDTQDENYFKDILSDNSGREDSENTFSPYQFKTSGPEKKPIPGIDVLSKKKIWA 300
            MGFLSIKDTQDENYFKDILSDNSGREDSENTFSPYQFKTSGPEKKPIPGIDVLSKKKIWA
Sbjct: 241  MGFLSIKDTQDENYFKDILSDNSGREDSENTFSPYQFKTSGPEKKPIPGIDVLSKKKIWA 300

Query: 301  SSMDLLCTADRDFSSGETATYRRCHPEAVTVRTSTTPRKKEARYSDGSIALDIFGPQKMD 360
            SSMDLLCTADRDFSSGETATYRRCHPEAVTVRTSTTPRKKEARYSDGSIALDIFGPQKMD
Sbjct: 301  SSMDLLCTADRDFSSGETATYRRCHPEAVTVRTSTTPRKKEARYSDGSIALDIFGPQKMD 360

Query: 361  PIYHTRELPTSSAISSALDRIRERQKKLQVLREAMNVEEPVRRYKTYHGDVFSTSSESPS 420
            PIYHTRELPTSSAISSALDRIRERQKKLQVLREAMNVEEPVRRYKTYHGDVFSTSSESPS
Sbjct: 361  PIYHTRELPTSSAISSALDRIRERQKKLQVLREAMNVEEPVRRYKTYHGDVFSTSSESPS 420

Query: 421  IISSESDFRQVRRSEASKRFESSSGLPGVDETLSQGQSQRPSRQYETPFEGNLINQEIML 480
            IISSESDFRQVRRSEASKRFESSSGLPGVDETLSQGQSQRPSRQYETPFEGNLINQEIML
Sbjct: 421  IISSESDFRQVRRSEASKRFESSSGLPGVDETLSQGQSQRPSRQYETPFEGNLINQEIML 480

Query: 481  KRQEEELMQLQAKMALRQSRLSLYPGDTIKASMLDITRDPLREIALETAMTQRKLRNFFG 540
            KRQEEELMQLQAKMALRQSRLSLYPGDTIKASMLDITRDPLREIALETAMTQRKLRNFFG
Sbjct: 481  KRQEEELMQLQAKMALRQSRLSLYPGDTIKASMLDITRDPLREIALETAMTQRKLRNFFG 540

Query: 541  PEFVKMTIEPFISLDLPRSILTKKGKNEDNRRKVNIMLLNGQRLELTCDTKTICKDVFDM 600
            PEFVKMTIEPFISLDLPRSILTKKGKNEDNRRKVNIMLLNGQRLELTCDTKTICKDVFDM
Sbjct: 541  PEFVKMTIEPFISLDLPRSILTKKGKNEDNRRKVNIMLLNGQRLELTCDTKTICKDVFDM 600

Query: 601  VVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTKVAPEGWKEEPKKKTKATVNFTLFFRI 660
            VVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTKVAPEGWKEEPKKKTKATVNFTLFFRI
Sbjct: 601  VVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTKVAPEGWKEEPKKKTKATVNFTLFFRI 660

Query: 661  KFFMDDVSLIQHTLTCHQYYLQLRKDILEERMHCDDETSLLLASLALQAEYGDYQPEVHG 720
            KFFMDDVSLIQHTLTCHQYYLQLRKDILEERMHCDDETSLLLASLALQAEYGDYQPEVHG
Sbjct: 661  KFFMDDVSLIQHTLTCHQYYLQLRKDILEERMHCDDETSLLLASLALQAEYGDYQPEVHG 720

Query: 721  VSYFRMEHYLPARVMEKLDLSYIKEELPKLHNTYVGASEKETELEFLKVCQRLTEYGVHF 780
            VSYFRMEHYLPARVMEKLDLSYIKEELPKLHNTYVGASEKETELEFLKVCQRLTEYGVHF
Sbjct: 721  VSYFRMEHYLPARVMEKLDLSYIKEELPKLHNTYVGASEKETELEFLKVCQRLTEYGVHF 780

Query: 781  HRVHPEKKSQTGILLGVCSKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKITLQNTSD 840
            HRVHPEKKSQTGILLGVCSKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKITLQNTSD
Sbjct: 781  HRVHPEKKSQTGILLGVCSKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKITLQNTSD 840

Query: 841  GIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDIDVLHKRWSIVSSPEREI 900
            GIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDIDVLHKRWSIVSSPEREI
Sbjct: 841  GIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDIDVLHKRWSIVSSPEREI 900

Query: 901  TLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVS 960
            TLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVS
Sbjct: 901  TLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVS 960

Query: 961  LEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAI 1020
            LEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAI
Sbjct: 961  LEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAI 1020

Query: 1021 DSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFASHLGD 1080
            DSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFASHLGD
Sbjct: 1021 DSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFASHLGD 1080

Query: 1081 QTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEATYSSS 1140
            QTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEATYSSS
Sbjct: 1081 QTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEATYSSS 1140

Query: 1141 QDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVR 1200
            QDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVR
Sbjct: 1141 QDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVR 1200

Query: 1201 HGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEK 1260
            HGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEK
Sbjct: 1201 HGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEK 1260

Query: 1261 GQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGL 1320
            GQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGL
Sbjct: 1261 GQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGL 1320

Query: 1321 GFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVI 1380
            GFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVI
Sbjct: 1321 GFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVI 1380

Query: 1381 SALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSD 1440
            SALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSD
Sbjct: 1381 SALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSD 1440

Query: 1441 ENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNSTWSSALHQTLSNMVSQAQ 1500
            ENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNSTWSSALHQTLSNMVSQAQ
Sbjct: 1441 ENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNSTWSSALHQTLSNMVSQAQ 1500

Query: 1501 SHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMAPGQSYQPQSESASSSSMD 1560
            SHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMAPGQSYQPQSESASSSSMD
Sbjct: 1501 SHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMAPGQSYQPQSESASSSSMD 1560

Query: 1561 KYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQRIG 1620
            KYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQRIG
Sbjct: 1561 KYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQRIG 1620

Query: 1621 CYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVLEL 1680
            CYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVLEL
Sbjct: 1621 CYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVLEL 1680

Query: 1681 PRIPMLPHLLPDITLTCNKEELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVI 1740
            PRIPMLPHLLPDITLTCNKEELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVI
Sbjct: 1681 PRIPMLPHLLPDITLTCNKEELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVI 1740

Query: 1741 HYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYS 1800
            HYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYS
Sbjct: 1741 HYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYS 1800

Query: 1801 VGSCSQPALTPNDSFSTVAGEEINEISYPKGKCSTYQIKGSPNLTLPKESYIQEDDIYDD 1860
            VGSCSQPALTPNDSFSTVAGEEINEISYPKGKCSTYQIKGSPNLTLPKESYIQEDDIYDD
Sbjct: 1801 VGSCSQPALTPNDSFSTVAGEEINEISYPKGKCSTYQIKGSPNLTLPKESYIQEDDIYDD 1860

Query: 1861 SQEAEVIQSLLDVVDEEAQNLLNENNAAGYSCGPGTLKMNGKLSEERTEDTDCDGSPLPE 1920
            SQEAEVIQSLLDVVDEEAQNLLNENNAAGYSCGPGTLKMNGKLSEERTEDTDCDGSPLPE
Sbjct: 1861 SQEAEVIQSLLDVVDEEAQNLLNENNAAGYSCGPGTLKMNGKLSEERTEDTDCDGSPLPE 1920

Query: 1921 YFTEATKMNGCEEYCEEKVKSESLIQKPQEKKTDDDEITWGNDELPIERTNHEDSDKDHS 1980
            YFTEATKMNGCEEYCEEKVKSESLIQKPQEKKTDDDEITWGNDELPIERTNHEDSDKDHS
Sbjct: 1921 YFTEATKMNGCEEYCEEKVKSESLIQKPQEKKTDDDEITWGNDELPIERTNHEDSDKDHS 1980

Query: 1981 FLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLI 2040
            FLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLI
Sbjct: 1981 FLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLI 2040

Query: 2041 GQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVG 2100
            GQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVG
Sbjct: 2041 GQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVG 2100

Query: 2101 DFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFV 2160
            DFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFV
Sbjct: 2101 DFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFV 2160

Query: 2161 VRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAG 2220
            VRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAG
Sbjct: 2161 VRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAG 2220

Query: 2221 IGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTRL 2280
            IGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTRL
Sbjct: 2221 IGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTRL 2280

Query: 2281 QAEEEQKQQPQLLK 2294
            QAEEEQKQQPQLLK
Sbjct: 2281 QAEEEQKQQPQLLK 2294


>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
            2 [Homo sapiens]
          Length = 2466

 Score = 2820 bits (7311), Expect = 0.0
 Identities = 1411/1412 (99%), Positives = 1412/1412 (100%)

Query: 883  IDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPAD 942
            +DVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPAD
Sbjct: 1055 LDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPAD 1114

Query: 943  LDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLT 1002
            LDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLT
Sbjct: 1115 LDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLT 1174

Query: 1003 NEMKNYMKKSSYMQDSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTES 1062
            NEMKNYMKKSSYMQDSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTES
Sbjct: 1175 NEMKNYMKKSSYMQDSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTES 1234

Query: 1063 ASLSQSQVNGFFASHLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVT 1122
            ASLSQSQVNGFFASHLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVT
Sbjct: 1235 ASLSQSQVNGFFASHLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVT 1294

Query: 1123 DYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAK 1182
            DYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAK
Sbjct: 1295 DYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAK 1354

Query: 1183 NDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQ 1242
            NDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQ
Sbjct: 1355 NDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQ 1414

Query: 1243 AVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSF 1302
            AVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSF
Sbjct: 1415 AVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSF 1474

Query: 1303 VTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDV 1362
            VTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDV
Sbjct: 1475 VTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDV 1534

Query: 1363 ILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPN 1422
            ILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPN
Sbjct: 1535 ILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPN 1594

Query: 1423 SSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNS 1482
            SSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNS
Sbjct: 1595 SSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNS 1654

Query: 1483 TWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMA 1542
            TWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMA
Sbjct: 1655 TWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMA 1714

Query: 1543 PGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIK 1602
            PGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIK
Sbjct: 1715 PGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIK 1774

Query: 1603 SEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNL 1662
            SEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNL
Sbjct: 1775 SEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNL 1834

Query: 1663 LRAASKTVRLVIGRVLELPRIPMLPHLLPDITLTCNKEELGFSLCGGHDSLYQVVYISDI 1722
            LRAASKTVRLVIGRVLELPRIPMLPHLLPDITLTCNKEELGFSLCGGHDSLYQVVYISDI
Sbjct: 1835 LRAASKTVRLVIGRVLELPRIPMLPHLLPDITLTCNKEELGFSLCGGHDSLYQVVYISDI 1894

Query: 1723 NPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSS 1782
            NPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSS
Sbjct: 1895 NPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSS 1954

Query: 1783 KRSAVSAPKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEEINEISYPKGKCSTYQIKGSP 1842
            KRSAVSAPKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEEINEISYPKGKCSTYQIKGSP
Sbjct: 1955 KRSAVSAPKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEEINEISYPKGKCSTYQIKGSP 2014

Query: 1843 NLTLPKESYIQEDDIYDDSQEAEVIQSLLDVVDEEAQNLLNENNAAGYSCGPGTLKMNGK 1902
            NLTLPKESYIQEDDIYDDSQEAEVIQSLLDVVDEEAQNLLNENNAAGYSCGPGTLKMNGK
Sbjct: 2015 NLTLPKESYIQEDDIYDDSQEAEVIQSLLDVVDEEAQNLLNENNAAGYSCGPGTLKMNGK 2074

Query: 1903 LSEERTEDTDCDGSPLPEYFTEATKMNGCEEYCEEKVKSESLIQKPQEKKTDDDEITWGN 1962
            LSEERTEDTDCDGSPLPEYFTEATKMNGCEEYCEEKVKSESLIQKPQEKKTDDDEITWGN
Sbjct: 2075 LSEERTEDTDCDGSPLPEYFTEATKMNGCEEYCEEKVKSESLIQKPQEKKTDDDEITWGN 2134

Query: 1963 DELPIERTNHEDSDKDHSFLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIP 2022
            DELPIERTNHEDSDKDHSFLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIP
Sbjct: 2135 DELPIERTNHEDSDKDHSFLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIP 2194

Query: 2023 SKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVG 2082
            SKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVG
Sbjct: 2195 SKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVG 2254

Query: 2083 KEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMV 2142
            KEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMV
Sbjct: 2255 KEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMV 2314

Query: 2143 SNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFIS 2202
            SNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFIS
Sbjct: 2315 SNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFIS 2374

Query: 2203 YMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQT 2262
            YMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQT
Sbjct: 2375 YMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQT 2434

Query: 2263 EDQYIFCYQVILYVLTRLQAEEEQKQQPQLLK 2294
            EDQYIFCYQVILYVLTRLQAEEEQKQQPQLLK
Sbjct: 2435 EDQYIFCYQVILYVLTRLQAEEEQKQQPQLLK 2466



 Score = 1796 bits (4653), Expect = 0.0
 Identities = 967/1278 (75%), Positives = 1029/1278 (80%), Gaps = 112/1278 (8%)

Query: 1    MHVSLAEALEVRGGPLQEEEIWAVLNQSAESLQELFRKVSLADPAALGFIISPWSLLLLP 60
            MHVSLAEALEVRGGPLQEEEIWAVLNQSAESLQELFRKVSLADPAALGFIISPWSLLLLP
Sbjct: 1    MHVSLAEALEVRGGPLQEEEIWAVLNQSAESLQELFRKVSLADPAALGFIISPWSLLLLP 60

Query: 61   SGSVSFTDENISNQDLRAFTAPEVLQNQSLTSLSDVEKIHIYSLGMTLYWGADYEVPQSQ 120
            SGSVSFTDENISNQDLRAFTAPEVLQNQSLTSLSDVEKIHIYSLGMTLYWGADYEVPQSQ
Sbjct: 61   SGSVSFTDENISNQDLRAFTAPEVLQNQSLTSLSDVEKIHIYSLGMTLYWGADYEVPQSQ 120

Query: 121  PIKLGDHLNSILLGMCEDVIYARVSVRTVLDACSAHIRNSNCAPSFSYVKHLVKLVLGNL 180
            PIKLGDHLNSILLGMCEDVIYARVSVRTVLDACSAHIRNSNCAPSFSYVKHLVKLVLGNL
Sbjct: 121  PIKLGDHLNSILLGMCEDVIYARVSVRTVLDACSAHIRNSNCAPSFSYVKHLVKLVLGNL 180

Query: 181  SGTDQLSCNSEQKPDRSQAIRDRLRGKGLPTGRSSTSDVLDIQKPPLSHQTFLNKGLSKS 240
            SGTDQLSCNSEQKPDRSQAIRDRLRGKGLPTGRSSTSDVLDIQKPPLSHQTFLNKGLSKS
Sbjct: 181  SGTDQLSCNSEQKPDRSQAIRDRLRGKGLPTGRSSTSDVLDIQKPPLSHQTFLNKGLSKS 240

Query: 241  MGFLSIKDTQDENYFKDILSDNSGREDSENTFSPYQFKTSGPEKKPIPGIDVLSKKKIWA 300
            MGFLSIKDTQDENYFKDILSDNSGREDSENTFSPYQFKTSGPEKKPIPGIDVLSKKKIWA
Sbjct: 241  MGFLSIKDTQDENYFKDILSDNSGREDSENTFSPYQFKTSGPEKKPIPGIDVLSKKKIWA 300

Query: 301  SSMDLLCTADRDFSSGETATYRRCHPEAVTVRTSTTPRKKEARYSDGSIALDIFGPQKMD 360
            SSMDLLCTADRDFSSGETATYRRCHPEAVTVRTSTTPRKKEARYSDGSIALDIFGPQKMD
Sbjct: 301  SSMDLLCTADRDFSSGETATYRRCHPEAVTVRTSTTPRKKEARYSDGSIALDIFGPQKMD 360

Query: 361  PIYHTRELPTSSAISSALDRIRERQKKLQVLREAMNVEEPVRRYKTYHGDVFSTSSESPS 420
            PIYHTRELPTSSAISSALDRIRERQKKLQVLREAMNVEEPVRRYKTYHGDVFSTSSESPS
Sbjct: 361  PIYHTRELPTSSAISSALDRIRERQKKLQVLREAMNVEEPVRRYKTYHGDVFSTSSESPS 420

Query: 421  IISSESDFRQVRRSEASKRFESSSGLPGVDETLSQGQSQRPSRQYETPFEGNLINQEIML 480
            IISSESDFRQVRRSEASKRFESSSGLPGVDETLSQGQSQRPSRQYETPFEGNLINQEIML
Sbjct: 421  IISSESDFRQVRRSEASKRFESSSGLPGVDETLSQGQSQRPSRQYETPFEGNLINQEIML 480

Query: 481  KRQEEELMQLQAKMALRQSRLSLYPGDTIKASMLDITRDPLREIALETAMTQRKLRNFFG 540
            KRQEEELMQLQAKMALRQSRLSLYPGDTIKASMLDITRDPLREIALETAMTQRKLRNFFG
Sbjct: 481  KRQEEELMQLQAKMALRQSRLSLYPGDTIKASMLDITRDPLREIALETAMTQRKLRNFFG 540

Query: 541  PEFVKMTIEPFISLDLPRSILTKKGKNEDNRRKVNIMLLNGQRLELTCDTKTICKDVFDM 600
            PEFVKMTIEPFISLDLPRSILTKKGKNEDNRRKVNIMLLNGQRLELTCDTKTICKDVFDM
Sbjct: 541  PEFVKMTIEPFISLDLPRSILTKKGKNEDNRRKVNIMLLNGQRLELTCDTKTICKDVFDM 600

Query: 601  VVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTKVAPEGWKEEPKKKTKATVNFTLFFRI 660
            VVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTKVAPEGWKEEPKKKTKATVNFTLFFRI
Sbjct: 601  VVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTKVAPEGWKEEPKKKTKATVNFTLFFRI 660

Query: 661  KFFMDDVSLIQHTLTCHQYYLQLRKDILEERMHCDDETSLLLASLALQAEYGDYQPEVHG 720
            KFFMDDVSLIQHTLTCHQYYLQLRKDILEERMHCDDETSLLLASLALQAEYGDYQPEVHG
Sbjct: 661  KFFMDDVSLIQHTLTCHQYYLQLRKDILEERMHCDDETSLLLASLALQAEYGDYQPEVHG 720

Query: 721  VSYFRMEHYLPARVMEKLDLSYIKEELPKLHNTYVGASEKETELEFLKVCQRLTEYGVHF 780
            VSYFRMEHYLPARVMEKLDLSYIKEELPKLHNTYVGASEKETELEFLKVCQRLTEYGVHF
Sbjct: 721  VSYFRMEHYLPARVMEKLDLSYIKEELPKLHNTYVGASEKETELEFLKVCQRLTEYGVHF 780

Query: 781  HRVHPEKKSQTGILLGVCSKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKITLQNTSD 840
            HRVHPEKKSQTGILLGVCSKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKITLQNTSD
Sbjct: 781  HRVHPEKKSQTGILLGVCSKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKITLQNTSD 840

Query: 841  GIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDIDVLHKRWSIVSSPEREI 900
            GIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDI+                
Sbjct: 841  GIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDIE------------RASF 888

Query: 901  TLVNLKKDAKYGLGFQIIGGEKMGR-LDLGIFISSVAPGGPADLDGCLKPGDRLISVNSV 959
              +NL+ ++        + G  MGR +  G   SS                    ++N +
Sbjct: 889  RSLNLQAES--------VRGFNMGRAISTGSLASS--------------------TLNKL 920

Query: 960  SLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSA 1019
            ++  +S  A I    +  E   L + QP +  SK         N+  ++ +K   M  S 
Sbjct: 921  AVRPLSVQAEILKRLSCSE---LSLYQPLQNSSKE-------KNDKASWEEKPREMSKSY 970

Query: 1020 IDSSSKDHHWSRGTLRHISENSFGPSGGLRE--GSLSSQDSRTESASLSQSQVNGFFASH 1077
             D S    +  R   +++  N   P   + E  G  S Q SR+++ SL+           
Sbjct: 971  HDLSQASLYPHR---KNVIVNMEPPPQTVAELVGKPSHQMSRSDAESLAG---------- 1017

Query: 1078 LGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEATY 1137
                              ++K    ++    N+S  ++   SD +   D G + + +  +
Sbjct: 1018 ------------------VTKLNNSKSVASLNRSPERRKHESDSSSIEDPGQAYVLDVLH 1059

Query: 1138 SSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDN-SLGISVTGGVN 1196
                   +P++E                         I  V L K+    LG  + GG  
Sbjct: 1060 KRWSIVSSPERE-------------------------ITLVNLKKDAKYGLGFQIIGGEK 1094

Query: 1197 TSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHL 1256
                  GI++ +V P G A+ DG +  GDR+++VN VSLEG +H  A+E L+N  + V L
Sbjct: 1095 MGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTL 1154

Query: 1257 LLEKGQSPTSKEHVPVTP 1274
            ++ + +   SK  VP TP
Sbjct: 1155 VISQPKEKISK--VPSTP 1170


>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
            isoform 1 [Homo sapiens]
          Length = 2485

 Score = 2820 bits (7310), Expect = 0.0
 Identities = 1423/1475 (96%), Positives = 1434/1475 (97%), Gaps = 14/1475 (0%)

Query: 825  KISFSKKKITLQNTSDGIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDI- 883
            K++ SK   +L  + +  KH  ++D+S I             + L M    S   +  + 
Sbjct: 1020 KLNNSKSVASLNRSPERRKH--ESDSSSIEDP-------GQAYVLGMTMHSSGNSSSQVP 1070

Query: 884  ----DVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGG 939
                DVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGG
Sbjct: 1071 LKENDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGG 1130

Query: 940  PADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPV 999
            PADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPV
Sbjct: 1131 PADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPV 1190

Query: 1000 HLTNEMKNYMKKSSYMQDSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSR 1059
            HLTNEMKNYMKKSSYMQDSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSR
Sbjct: 1191 HLTNEMKNYMKKSSYMQDSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSR 1250

Query: 1060 TESASLSQSQVNGFFASHLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGIS 1119
            TESASLSQSQVNGFFASHLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGIS
Sbjct: 1251 TESASLSQSQVNGFFASHLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGIS 1310

Query: 1120 DVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVE 1179
            DVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVE
Sbjct: 1311 DVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVE 1370

Query: 1180 LAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGAT 1239
            LAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGAT
Sbjct: 1371 LAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGAT 1430

Query: 1240 HKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKD 1299
            HKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKD
Sbjct: 1431 HKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKD 1490

Query: 1300 YSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDV 1359
            YSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDV
Sbjct: 1491 YSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDV 1550

Query: 1360 GDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQV 1419
            GDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQV
Sbjct: 1551 GDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQV 1610

Query: 1420 LPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANI 1479
            LPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANI
Sbjct: 1611 LPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANI 1670

Query: 1480 SNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPP 1539
            SNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPP
Sbjct: 1671 SNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPP 1730

Query: 1540 DMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLIT 1599
            DMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLIT
Sbjct: 1731 DMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLIT 1790

Query: 1600 LIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNMTHTDA 1659
            LIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNMTHTDA
Sbjct: 1791 LIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNMTHTDA 1850

Query: 1660 VNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDITLTCNKEELGFSLCGGHDSLYQVVYI 1719
            VNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDITLTCNKEELGFSLCGGHDSLYQVVYI
Sbjct: 1851 VNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDITLTCNKEELGFSLCGGHDSLYQVVYI 1910

Query: 1720 SDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVV 1779
            SDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVV
Sbjct: 1911 SDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVV 1970

Query: 1780 PSSKRSAVSAPKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEEINEISYPKGKCSTYQIK 1839
            PSSKRSAVSAPKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEEINEISYPKGKCSTYQIK
Sbjct: 1971 PSSKRSAVSAPKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEEINEISYPKGKCSTYQIK 2030

Query: 1840 GSPNLTLPKESYIQEDDIYDDSQEAEVIQSLLDVVDEEAQNLLNENNAAGYSCGPGTLKM 1899
            GSPNLTLPKESYIQEDDIYDDSQEAEVIQSLLDVVDEEAQNLLNENNAAGYSCGPGTLKM
Sbjct: 2031 GSPNLTLPKESYIQEDDIYDDSQEAEVIQSLLDVVDEEAQNLLNENNAAGYSCGPGTLKM 2090

Query: 1900 NGKLSEERTEDTDCDGSPLPEYFTEATKMNGCEEYCEEKVKSESLIQKPQEKKTDDDEIT 1959
            NGKLSEERTEDTDCDGSPLPEYFTEATKMNGCEEYCEEKVKSESLIQKPQEKKTDDDEIT
Sbjct: 2091 NGKLSEERTEDTDCDGSPLPEYFTEATKMNGCEEYCEEKVKSESLIQKPQEKKTDDDEIT 2150

Query: 1960 WGNDELPIERTNHEDSDKDHSFLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQ 2019
            WGNDELPIERTNHEDSDKDHSFLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQ
Sbjct: 2151 WGNDELPIERTNHEDSDKDHSFLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQ 2210

Query: 2020 GIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKI 2079
            GIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKI
Sbjct: 2211 GIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKI 2270

Query: 2080 PVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKT 2139
            PVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKT
Sbjct: 2271 PVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKT 2330

Query: 2140 TMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLT 2199
            TMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLT
Sbjct: 2331 TMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLT 2390

Query: 2200 FISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGM 2259
            FISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGM
Sbjct: 2391 FISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGM 2450

Query: 2260 VQTEDQYIFCYQVILYVLTRLQAEEEQKQQPQLLK 2294
            VQTEDQYIFCYQVILYVLTRLQAEEEQKQQPQLLK
Sbjct: 2451 VQTEDQYIFCYQVILYVLTRLQAEEEQKQQPQLLK 2485



 Score = 1805 bits (4675), Expect = 0.0
 Identities = 974/1280 (76%), Positives = 1035/1280 (80%), Gaps = 97/1280 (7%)

Query: 1    MHVSLAEALEVRGGPLQEEEIWAVLNQSAESLQELFRKVSLADPAALGFIISPWSLLLLP 60
            MHVSLAEALEVRGGPLQEEEIWAVLNQSAESLQELFRKVSLADPAALGFIISPWSLLLLP
Sbjct: 1    MHVSLAEALEVRGGPLQEEEIWAVLNQSAESLQELFRKVSLADPAALGFIISPWSLLLLP 60

Query: 61   SGSVSFTDENISNQDLRAFTAPEVLQNQSLTSLSDVEKIHIYSLGMTLYWGADYEVPQSQ 120
            SGSVSFTDENISNQDLRAFTAPEVLQNQSLTSLSDVEKIHIYSLGMTLYWGADYEVPQSQ
Sbjct: 61   SGSVSFTDENISNQDLRAFTAPEVLQNQSLTSLSDVEKIHIYSLGMTLYWGADYEVPQSQ 120

Query: 121  PIKLGDHLNSILLGMCEDVIYARVSVRTVLDACSAHIRNSNCAPSFSYVKHLVKLVLGNL 180
            PIKLGDHLNSILLGMCEDVIYARVSVRTVLDACSAHIRNSNCAPSFSYVKHLVKLVLGNL
Sbjct: 121  PIKLGDHLNSILLGMCEDVIYARVSVRTVLDACSAHIRNSNCAPSFSYVKHLVKLVLGNL 180

Query: 181  SGTDQLSCNSEQKPDRSQAIRDRLRGKGLPTGRSSTSDVLDIQKPPLSHQTFLNKGLSKS 240
            SGTDQLSCNSEQKPDRSQAIRDRLRGKGLPTGRSSTSDVLDIQKPPLSHQTFLNKGLSKS
Sbjct: 181  SGTDQLSCNSEQKPDRSQAIRDRLRGKGLPTGRSSTSDVLDIQKPPLSHQTFLNKGLSKS 240

Query: 241  MGFLSIKDTQDENYFKDILSDNSGREDSENTFSPYQFKTSGPEKKPIPGIDVLSKKKIWA 300
            MGFLSIKDTQDENYFKDILSDNSGREDSENTFSPYQFKTSGPEKKPIPGIDVLSKKKIWA
Sbjct: 241  MGFLSIKDTQDENYFKDILSDNSGREDSENTFSPYQFKTSGPEKKPIPGIDVLSKKKIWA 300

Query: 301  SSMDLLCTADRDFSSGETATYRRCHPEAVTVRTSTTPRKKEARYSDGSIALDIFGPQKMD 360
            SSMDLLCTADRDFSSGETATYRRCHPEAVTVRTSTTPRKKEARYSDGSIALDIFGPQKMD
Sbjct: 301  SSMDLLCTADRDFSSGETATYRRCHPEAVTVRTSTTPRKKEARYSDGSIALDIFGPQKMD 360

Query: 361  PIYHTRELPTSSAISSALDRIRERQKKLQVLREAMNVEEPVRRYKTYHGDVFSTSSESPS 420
            PIYHTRELPTSSAISSALDRIRERQKKLQVLREAMNVEEPVRRYKTYHGDVFSTSSESPS
Sbjct: 361  PIYHTRELPTSSAISSALDRIRERQKKLQVLREAMNVEEPVRRYKTYHGDVFSTSSESPS 420

Query: 421  IISSESDFRQVRRSEASKRFESSSGLPGVDETLSQGQSQRPSRQYETPFEGNLINQEIML 480
            IISSESDFRQVRRSEASKRFESSSGLPGVDETLSQGQSQRPSRQYETPFEGNLINQEIML
Sbjct: 421  IISSESDFRQVRRSEASKRFESSSGLPGVDETLSQGQSQRPSRQYETPFEGNLINQEIML 480

Query: 481  KRQEEELMQLQAKMALRQSRLSLYPGDTIKASMLDITRDPLREIALETAMTQRKLRNFFG 540
            KRQEEELMQLQAKMALRQSRLSLYPGDTIKASMLDITRDPLREIALETAMTQRKLRNFFG
Sbjct: 481  KRQEEELMQLQAKMALRQSRLSLYPGDTIKASMLDITRDPLREIALETAMTQRKLRNFFG 540

Query: 541  PEFVKMTIEPFISLDLPRSILTKKGKNEDNRRKVNIMLLNGQRLELTCDTKTICKDVFDM 600
            PEFVKMTIEPFISLDLPRSILTKKGKNEDNRRKVNIMLLNGQRLELTCDTKTICKDVFDM
Sbjct: 541  PEFVKMTIEPFISLDLPRSILTKKGKNEDNRRKVNIMLLNGQRLELTCDTKTICKDVFDM 600

Query: 601  VVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTKVAPEGWKEEPKKKTKATVNFTLFFRI 660
            VVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTKVAPEGWKEEPKKKTKATVNFTLFFRI
Sbjct: 601  VVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTKVAPEGWKEEPKKKTKATVNFTLFFRI 660

Query: 661  KFFMDDVSLIQHTLTCHQYYLQLRKDILEERMHCDDETSLLLASLALQAEYGDYQPEVHG 720
            KFFMDDVSLIQHTLTCHQYYLQLRKDILEERMHCDDETSLLLASLALQAEYGDYQPEVHG
Sbjct: 661  KFFMDDVSLIQHTLTCHQYYLQLRKDILEERMHCDDETSLLLASLALQAEYGDYQPEVHG 720

Query: 721  VSYFRMEHYLPARVMEKLDLSYIKEELPKLHNTYVGASEKETELEFLKVCQRLTEYGVHF 780
            VSYFRMEHYLPARVMEKLDLSYIKEELPKLHNTYVGASEKETELEFLKVCQRLTEYGVHF
Sbjct: 721  VSYFRMEHYLPARVMEKLDLSYIKEELPKLHNTYVGASEKETELEFLKVCQRLTEYGVHF 780

Query: 781  HRVHPEKKSQTGILLGVCSKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKITLQNTSD 840
            HRVHPEKKSQTGILLGVCSKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKITLQNTSD
Sbjct: 781  HRVHPEKKSQTGILLGVCSKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKITLQNTSD 840

Query: 841  GIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDIDVLHKRWSIVSSPEREI 900
            GIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDI+                
Sbjct: 841  GIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDIE------------RASF 888

Query: 901  TLVNLKKDAKYGLGFQIIGGEKMGR-LDLGIFISSVAPGGPADLDGCLKPGDRLISVNSV 959
              +NL+ ++        + G  MGR +  G   SS                    ++N +
Sbjct: 889  RSLNLQAES--------VRGFNMGRAISTGSLASS--------------------TLNKL 920

Query: 960  SLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSA 1019
            ++  +S  A I    +  E   L + QP +  SK         N+  ++ +K   M  S 
Sbjct: 921  AVRPLSVQAEILKRLSCSE---LSLYQPLQNSSKE-------KNDKASWEEKPREMSKSY 970

Query: 1020 IDSSSKDHHWSRGTLRHISENSFGPSGGLRE--GSLSSQDSRTESASLSQSQVNGFFASH 1077
             D S    +  R   +++  N   P   + E  G  S Q SR+++ SL+           
Sbjct: 971  HDLSQASLYPHR---KNVIVNMEPPPQTVAELVGKPSHQMSRSDAESLAG---------- 1017

Query: 1078 LGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEATY 1137
                              ++K    ++    N+S  ++   SD +   D G + +   T 
Sbjct: 1018 ------------------VTKLNNSKSVASLNRSPERRKHESDSSSIEDPGQAYVLGMTM 1059

Query: 1138 SSS--QDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDN-SLGISVTGG 1194
             SS     Q P +E        N +  K +S       +I  V L K+    LG  + GG
Sbjct: 1060 HSSGNSSSQVPLKE--------NDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGG 1111

Query: 1195 VNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVV 1254
                    GI++ +V P G A+ DG +  GDR+++VN VSLEG +H  A+E L+N  + V
Sbjct: 1112 EKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDV 1171

Query: 1255 HLLLEKGQSPTSKEHVPVTP 1274
             L++ + +   SK  VP TP
Sbjct: 1172 TLVISQPKEKISK--VPSTP 1189


>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
            isoform 4 [Homo sapiens]
          Length = 2490

 Score = 2814 bits (7294), Expect = 0.0
 Identities = 1423/1480 (96%), Positives = 1434/1480 (96%), Gaps = 19/1480 (1%)

Query: 825  KISFSKKKITLQNTSDGIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDI- 883
            K++ SK   +L  + +  KH  ++D+S I             + L M    S   +  + 
Sbjct: 1020 KLNNSKSVASLNRSPERRKH--ESDSSSIEDP-------GQAYVLGMTMHSSGNSSSQVP 1070

Query: 884  ----DVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGG 939
                DVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGG
Sbjct: 1071 LKENDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGG 1130

Query: 940  PADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPV 999
            PADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPV
Sbjct: 1131 PADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPV 1190

Query: 1000 HLTNEMKNYMKKSSYMQDSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSR 1059
            HLTNEMKNYMKKSSYMQDSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSR
Sbjct: 1191 HLTNEMKNYMKKSSYMQDSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSR 1250

Query: 1060 TESASLSQSQVNGFFASHLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGIS 1119
            TESASLSQSQVNGFFASHLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGIS
Sbjct: 1251 TESASLSQSQVNGFFASHLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGIS 1310

Query: 1120 DVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVE 1179
            DVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVE
Sbjct: 1311 DVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVE 1370

Query: 1180 LAKNDNSLGISVT-----GGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVS 1234
            LAKNDNSLGISVT     GGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVS
Sbjct: 1371 LAKNDNSLGISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVS 1430

Query: 1235 LEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKT 1294
            LEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKT
Sbjct: 1431 LEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKT 1490

Query: 1295 TQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAES 1354
            TQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAES
Sbjct: 1491 TQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAES 1550

Query: 1355 GKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQ 1414
            GKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQ
Sbjct: 1551 GKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQ 1610

Query: 1415 SPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVT 1474
            SPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVT
Sbjct: 1611 SPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVT 1670

Query: 1475 APANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNP 1534
            APANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNP
Sbjct: 1671 APANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNP 1730

Query: 1535 SPLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEV 1594
            SPLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEV
Sbjct: 1731 SPLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEV 1790

Query: 1595 ELLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNM 1654
            ELLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNM
Sbjct: 1791 ELLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNM 1850

Query: 1655 THTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDITLTCNKEELGFSLCGGHDSLY 1714
            THTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDITLTCNKEELGFSLCGGHDSLY
Sbjct: 1851 THTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDITLTCNKEELGFSLCGGHDSLY 1910

Query: 1715 QVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRN 1774
            QVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRN
Sbjct: 1911 QVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRN 1970

Query: 1775 DLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEEINEISYPKGKCS 1834
            DLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEEINEISYPKGKCS
Sbjct: 1971 DLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEEINEISYPKGKCS 2030

Query: 1835 TYQIKGSPNLTLPKESYIQEDDIYDDSQEAEVIQSLLDVVDEEAQNLLNENNAAGYSCGP 1894
            TYQIKGSPNLTLPKESYIQEDDIYDDSQEAEVIQSLLDVVDEEAQNLLNENNAAGYSCGP
Sbjct: 2031 TYQIKGSPNLTLPKESYIQEDDIYDDSQEAEVIQSLLDVVDEEAQNLLNENNAAGYSCGP 2090

Query: 1895 GTLKMNGKLSEERTEDTDCDGSPLPEYFTEATKMNGCEEYCEEKVKSESLIQKPQEKKTD 1954
            GTLKMNGKLSEERTEDTDCDGSPLPEYFTEATKMNGCEEYCEEKVKSESLIQKPQEKKTD
Sbjct: 2091 GTLKMNGKLSEERTEDTDCDGSPLPEYFTEATKMNGCEEYCEEKVKSESLIQKPQEKKTD 2150

Query: 1955 DDEITWGNDELPIERTNHEDSDKDHSFLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLR 2014
            DDEITWGNDELPIERTNHEDSDKDHSFLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLR
Sbjct: 2151 DDEITWGNDELPIERTNHEDSDKDHSFLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLR 2210

Query: 2015 GLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYINA 2074
            GLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYINA
Sbjct: 2211 GLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYINA 2270

Query: 2075 SFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPN 2134
            SFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPN
Sbjct: 2271 SFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPN 2330

Query: 2135 ILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQP 2194
            ILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQP
Sbjct: 2331 ILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQP 2390

Query: 2195 DDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRL 2254
            DDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRL
Sbjct: 2391 DDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRL 2450

Query: 2255 QRHGMVQTEDQYIFCYQVILYVLTRLQAEEEQKQQPQLLK 2294
            QRHGMVQTEDQYIFCYQVILYVLTRLQAEEEQKQQPQLLK
Sbjct: 2451 QRHGMVQTEDQYIFCYQVILYVLTRLQAEEEQKQQPQLLK 2490



 Score = 1805 bits (4675), Expect = 0.0
 Identities = 974/1280 (76%), Positives = 1035/1280 (80%), Gaps = 97/1280 (7%)

Query: 1    MHVSLAEALEVRGGPLQEEEIWAVLNQSAESLQELFRKVSLADPAALGFIISPWSLLLLP 60
            MHVSLAEALEVRGGPLQEEEIWAVLNQSAESLQELFRKVSLADPAALGFIISPWSLLLLP
Sbjct: 1    MHVSLAEALEVRGGPLQEEEIWAVLNQSAESLQELFRKVSLADPAALGFIISPWSLLLLP 60

Query: 61   SGSVSFTDENISNQDLRAFTAPEVLQNQSLTSLSDVEKIHIYSLGMTLYWGADYEVPQSQ 120
            SGSVSFTDENISNQDLRAFTAPEVLQNQSLTSLSDVEKIHIYSLGMTLYWGADYEVPQSQ
Sbjct: 61   SGSVSFTDENISNQDLRAFTAPEVLQNQSLTSLSDVEKIHIYSLGMTLYWGADYEVPQSQ 120

Query: 121  PIKLGDHLNSILLGMCEDVIYARVSVRTVLDACSAHIRNSNCAPSFSYVKHLVKLVLGNL 180
            PIKLGDHLNSILLGMCEDVIYARVSVRTVLDACSAHIRNSNCAPSFSYVKHLVKLVLGNL
Sbjct: 121  PIKLGDHLNSILLGMCEDVIYARVSVRTVLDACSAHIRNSNCAPSFSYVKHLVKLVLGNL 180

Query: 181  SGTDQLSCNSEQKPDRSQAIRDRLRGKGLPTGRSSTSDVLDIQKPPLSHQTFLNKGLSKS 240
            SGTDQLSCNSEQKPDRSQAIRDRLRGKGLPTGRSSTSDVLDIQKPPLSHQTFLNKGLSKS
Sbjct: 181  SGTDQLSCNSEQKPDRSQAIRDRLRGKGLPTGRSSTSDVLDIQKPPLSHQTFLNKGLSKS 240

Query: 241  MGFLSIKDTQDENYFKDILSDNSGREDSENTFSPYQFKTSGPEKKPIPGIDVLSKKKIWA 300
            MGFLSIKDTQDENYFKDILSDNSGREDSENTFSPYQFKTSGPEKKPIPGIDVLSKKKIWA
Sbjct: 241  MGFLSIKDTQDENYFKDILSDNSGREDSENTFSPYQFKTSGPEKKPIPGIDVLSKKKIWA 300

Query: 301  SSMDLLCTADRDFSSGETATYRRCHPEAVTVRTSTTPRKKEARYSDGSIALDIFGPQKMD 360
            SSMDLLCTADRDFSSGETATYRRCHPEAVTVRTSTTPRKKEARYSDGSIALDIFGPQKMD
Sbjct: 301  SSMDLLCTADRDFSSGETATYRRCHPEAVTVRTSTTPRKKEARYSDGSIALDIFGPQKMD 360

Query: 361  PIYHTRELPTSSAISSALDRIRERQKKLQVLREAMNVEEPVRRYKTYHGDVFSTSSESPS 420
            PIYHTRELPTSSAISSALDRIRERQKKLQVLREAMNVEEPVRRYKTYHGDVFSTSSESPS
Sbjct: 361  PIYHTRELPTSSAISSALDRIRERQKKLQVLREAMNVEEPVRRYKTYHGDVFSTSSESPS 420

Query: 421  IISSESDFRQVRRSEASKRFESSSGLPGVDETLSQGQSQRPSRQYETPFEGNLINQEIML 480
            IISSESDFRQVRRSEASKRFESSSGLPGVDETLSQGQSQRPSRQYETPFEGNLINQEIML
Sbjct: 421  IISSESDFRQVRRSEASKRFESSSGLPGVDETLSQGQSQRPSRQYETPFEGNLINQEIML 480

Query: 481  KRQEEELMQLQAKMALRQSRLSLYPGDTIKASMLDITRDPLREIALETAMTQRKLRNFFG 540
            KRQEEELMQLQAKMALRQSRLSLYPGDTIKASMLDITRDPLREIALETAMTQRKLRNFFG
Sbjct: 481  KRQEEELMQLQAKMALRQSRLSLYPGDTIKASMLDITRDPLREIALETAMTQRKLRNFFG 540

Query: 541  PEFVKMTIEPFISLDLPRSILTKKGKNEDNRRKVNIMLLNGQRLELTCDTKTICKDVFDM 600
            PEFVKMTIEPFISLDLPRSILTKKGKNEDNRRKVNIMLLNGQRLELTCDTKTICKDVFDM
Sbjct: 541  PEFVKMTIEPFISLDLPRSILTKKGKNEDNRRKVNIMLLNGQRLELTCDTKTICKDVFDM 600

Query: 601  VVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTKVAPEGWKEEPKKKTKATVNFTLFFRI 660
            VVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTKVAPEGWKEEPKKKTKATVNFTLFFRI
Sbjct: 601  VVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTKVAPEGWKEEPKKKTKATVNFTLFFRI 660

Query: 661  KFFMDDVSLIQHTLTCHQYYLQLRKDILEERMHCDDETSLLLASLALQAEYGDYQPEVHG 720
            KFFMDDVSLIQHTLTCHQYYLQLRKDILEERMHCDDETSLLLASLALQAEYGDYQPEVHG
Sbjct: 661  KFFMDDVSLIQHTLTCHQYYLQLRKDILEERMHCDDETSLLLASLALQAEYGDYQPEVHG 720

Query: 721  VSYFRMEHYLPARVMEKLDLSYIKEELPKLHNTYVGASEKETELEFLKVCQRLTEYGVHF 780
            VSYFRMEHYLPARVMEKLDLSYIKEELPKLHNTYVGASEKETELEFLKVCQRLTEYGVHF
Sbjct: 721  VSYFRMEHYLPARVMEKLDLSYIKEELPKLHNTYVGASEKETELEFLKVCQRLTEYGVHF 780

Query: 781  HRVHPEKKSQTGILLGVCSKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKITLQNTSD 840
            HRVHPEKKSQTGILLGVCSKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKITLQNTSD
Sbjct: 781  HRVHPEKKSQTGILLGVCSKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKITLQNTSD 840

Query: 841  GIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDIDVLHKRWSIVSSPEREI 900
            GIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDI+                
Sbjct: 841  GIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDIE------------RASF 888

Query: 901  TLVNLKKDAKYGLGFQIIGGEKMGR-LDLGIFISSVAPGGPADLDGCLKPGDRLISVNSV 959
              +NL+ ++        + G  MGR +  G   SS                    ++N +
Sbjct: 889  RSLNLQAES--------VRGFNMGRAISTGSLASS--------------------TLNKL 920

Query: 960  SLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSA 1019
            ++  +S  A I    +  E   L + QP +  SK         N+  ++ +K   M  S 
Sbjct: 921  AVRPLSVQAEILKRLSCSE---LSLYQPLQNSSKE-------KNDKASWEEKPREMSKSY 970

Query: 1020 IDSSSKDHHWSRGTLRHISENSFGPSGGLRE--GSLSSQDSRTESASLSQSQVNGFFASH 1077
             D S    +  R   +++  N   P   + E  G  S Q SR+++ SL+           
Sbjct: 971  HDLSQASLYPHR---KNVIVNMEPPPQTVAELVGKPSHQMSRSDAESLAG---------- 1017

Query: 1078 LGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEATY 1137
                              ++K    ++    N+S  ++   SD +   D G + +   T 
Sbjct: 1018 ------------------VTKLNNSKSVASLNRSPERRKHESDSSSIEDPGQAYVLGMTM 1059

Query: 1138 SSS--QDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDN-SLGISVTGG 1194
             SS     Q P +E        N +  K +S       +I  V L K+    LG  + GG
Sbjct: 1060 HSSGNSSSQVPLKE--------NDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGG 1111

Query: 1195 VNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVV 1254
                    GI++ +V P G A+ DG +  GDR+++VN VSLEG +H  A+E L+N  + V
Sbjct: 1112 EKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDV 1171

Query: 1255 HLLLEKGQSPTSKEHVPVTP 1274
             L++ + +   SK  VP TP
Sbjct: 1172 TLVISQPKEKISK--VPSTP 1189


>gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo
            sapiens]
          Length = 1287

 Score =  489 bits (1259), Expect = e-137
 Identities = 342/970 (35%), Positives = 516/970 (53%), Gaps = 96/970 (9%)

Query: 538  FFGPEFVKMTIEPFISLDLPRSILTKKGKNEDNRRKVNIMLLNGQRLELTCDTKTICKDV 597
            F  PEF+ +  E  ++L LP S++TKKGK+    R + ++LLNGQ LE+ CD ++    V
Sbjct: 286  FSRPEFILLAGEAPMTLHLPGSVVTKKGKSYLALRDLCVVLLNGQHLEVKCDVESTVGAV 345

Query: 598  FDMVVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTKVAPEGWKEEPKKKTKATVNFTLF 657
            F+ V +   L E   F LA +K  E+FF+D + +L K+APEGW+E+P+K +  T  FTLF
Sbjct: 346  FNAVTSFANLEELTYFGLAYMKSKEFFFLDSETRLCKIAPEGWREQPQKTSMNT--FTLF 403

Query: 658  FRIKFFMDDVSLIQHTLTCHQYYLQLRKDILEERMHCDDETSLLLASLALQAEYGDYQPE 717
             RIKFF+    L+QH+LT HQ+YLQLRKDILEER++C++E  L L  LALQAE+G+Y  E
Sbjct: 404  LRIKFFVSHYGLLQHSLTRHQFYLQLRKDILEERLYCNEEILLQLGVLALQAEFGNYPKE 463

Query: 718  -VHGVSYFRMEHYLPARVMEKLDLSYIKEELPKLHNTYVGASEKETELEFLKVCQRLTEY 776
             V    YF +E Y+PA ++E++    ++ E+ ++H        ++ EL+FL+V Q+L EY
Sbjct: 464  QVESKPYFHVEDYIPASLIERMTALRVQVEVSEMHRLSSALWGEDAELKFLRVTQQLPEY 523

Query: 777  GVHFHRVHPEKKS-QTGILLGVCSKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKITL 835
            GV  H+V  EK+  +  + LG+C+KGV+V+EV N  R  +LRF WRET KIS  +KK T+
Sbjct: 524  GVLVHQVFSEKRRPEEEMALGICAKGVIVYEVKNNSRIAMLRFQWRETGKISTYQKKFTI 583

Query: 836  QNTSDGIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDIDVLHKRWSIVSS 895
             ++  G KH F TD++K  +YLL LCS QH F  QM + Q +              ++  
Sbjct: 584  TSSVTGKKHTFVTDSAKTSKYLLDLCSAQHGFNAQMGSGQPSH-------------VLFD 630

Query: 896  PEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSV--APGG--PADLDGCLKPGD 951
             ++ + + NL   A       +I  +++   +  +F+S +  A GG     +D     G 
Sbjct: 631  HDKFVQMANLSP-AHQARSKPLIWIQRLSCSENELFVSRLQGAAGGLLSTSMDNFNVDGS 689

Query: 952  RLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPK--EKISKVPSTPVHLTNEMKNYM 1009
            +      +   G S     E L++A      VI +P   + +S  P   +H  +  KN  
Sbjct: 690  KEAGAEGI---GRSPCTGREQLKSA-----CVIQKPMTWDSLSGPPVQSMHAGS--KNNR 739

Query: 1010 KKSSYMQ---DSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSL----SSQDSRT-- 1060
            +KS   +   +    +  +D H   G + +  E S     G+   S+     ++ ++T  
Sbjct: 740  RKSFIAEPGREIVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIK 799

Query: 1061 ---ESASLSQSQVNGFFASHLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPG 1117
               +  +L+   + GF   ++  +  Q S          SK        D  ++ T   G
Sbjct: 800  PGGQILALNHISLEGF-TFNMAVRMIQNSPDNIELIISQSKGVGGNN-PDEEKNSTANSG 857

Query: 1118 IS--DVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTF--------SS 1167
            +S  D+  +  +G       +++  QD  T + + +   +   ++  +          SS
Sbjct: 858  VSSTDILSFGYQGSL----LSHTQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSS 913

Query: 1168 SPPKP-----GDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIH 1222
             PP P     G+I+ VEL K D +LG SVTGG+NTSV +GGIYVK+++P G A  +G+I 
Sbjct: 914  CPPSPPEISAGEIYFVELVKEDGTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQIL 973

Query: 1223 KGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQN 1282
            +GDR+L V+GV L G THKQAV+ L   GQV  L+LE+         VP + Q   S  +
Sbjct: 974  QGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLER--------RVPRSTQQCPSAND 1025

Query: 1283 AQGQGPEKVKKTTQV----KDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINAS 1338
            + G     V   T +         VT+   FEVKL KN++GLGFSF + +      + + 
Sbjct: 1026 SMGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSD 1085

Query: 1339 IVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPP 1398
            +VR+K+LFPGQPA E+G I  GD+IL VNG S +GL  QEV+  LRG   EV LLLCRPP
Sbjct: 1086 LVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPP 1145

Query: 1399 PGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRR 1458
            PG LPE++    TP  S       + K+ ++ +C +  TS   ++            S R
Sbjct: 1146 PGALPELEQEWQTPELS-------ADKEFTRATCTDSCTSPILDQ----------EDSWR 1188

Query: 1459 DSYSDSSGSG 1468
            DS S  +G G
Sbjct: 1189 DSASPDAGEG 1198



 Score =  108 bits (271), Expect = 5e-23
 Identities = 76/208 (36%), Positives = 115/208 (55%), Gaps = 33/208 (15%)

Query: 3   VSLAEALEVRGGPLQEEEIWAVLNQSAESLQELFRKVSLADPAALGFIISPWSLLLLPSG 62
           V+LA AL+VRG  L EEEIW++L  +AE L E  R  S        +++ PWS LL  +G
Sbjct: 15  VTLASALQVRGEALSEEEIWSLLFLAAEQLLEDLRNDSS------DYVVCPWSALLSAAG 68

Query: 63  SVSFTDENISNQDLRAFTAPEVLQNQSLTSLSDVEKIHIYSLGMTLYWGADYEVPQSQPI 122
           S+SF    +S+ +   F APE+LQ QS                       D +   SQP+
Sbjct: 69  SLSFQGR-VSHIEAAPFKAPELLQGQS----------------------EDEQPDASQPL 105

Query: 123 KLGDHLNSILLGMCEDVIYARVSVRTVLDACSAHIRNSNC--APSFSYVKHLVKLVLGNL 180
           +L + L+SILL MCED  + R ++++VL+AC  H +  +   AP+  +++ LV LVLG +
Sbjct: 106 QLCEPLHSILLTMCEDQPHRRCTLQSVLEACRVHEKEVSVYPAPAGLHIRRLVGLVLGTI 165

Query: 181 SGTDQ--LSCNSEQKPDRSQAIRDRLRG 206
           S  ++  +  +S  + +RS  +R RLRG
Sbjct: 166 SEVEKRVVEESSSVQQNRSYLLRKRLRG 193



 Score = 60.8 bits (146), Expect = 1e-08
 Identities = 73/277 (26%), Positives = 110/277 (39%), Gaps = 50/277 (18%)

Query: 1595 ELLITLIKSEKGSLGFTVTKG-NQRI---GCYVHDVIQD-PAKSDGRLKPGDRLIKVNDT 1649
            E+    +  E G+LGF+VT G N  +   G YV  ++   PA  +G++  GDRL++V+  
Sbjct: 925  EIYFVELVKEDGTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGV 984

Query: 1650 DVTNMTHTDAVNLLRAASKTVRLVIGR-------------------------VLELPRIP 1684
             +  +TH  AV  L    +  RLV+ R                         V  LP  P
Sbjct: 985  ILCGLTHKQAVQCLTGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAVSLVTALPGRP 1044

Query: 1685 MLPHLLPD-----ITLTCNKEELGFSL-------CGGHDSLYQVVYISDINPRSVAAIEG 1732
                 + D     + L  N   LGFS        C    S   +V I  + P   A   G
Sbjct: 1045 SSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKS--DLVRIKRLFPGQPAEENG 1102

Query: 1733 NLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRS----AVS 1788
             +   D+I  VNG ST+G+  +EV   L  +   + L   R     +P  ++      +S
Sbjct: 1103 AIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPELEQEWQTPELS 1162

Query: 1789 APKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEEINE 1825
            A K  +   +    SC+ P L   DS+   A  +  E
Sbjct: 1163 ADK--EFTRATCTDSCTSPILDQEDSWRDSASPDAGE 1197



 Score = 32.7 bits (73), Expect = 4.2
 Identities = 18/84 (21%), Positives = 39/84 (46%), Gaps = 5/84 (5%)

Query: 1598 ITLIKSEKGSLGFTVTKGNQR----IGCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVT 1652
            +TL +      GF + +G        G ++  +I   PA+    +KPG +++ +N   + 
Sbjct: 754  VTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLE 813

Query: 1653 NMTHTDAVNLLRAASKTVRLVIGR 1676
              T   AV +++ +   + L+I +
Sbjct: 814  GFTFNMAVRMIQNSPDNIELIISQ 837


>gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo
            sapiens]
          Length = 1309

 Score =  489 bits (1259), Expect = e-137
 Identities = 342/970 (35%), Positives = 516/970 (53%), Gaps = 96/970 (9%)

Query: 538  FFGPEFVKMTIEPFISLDLPRSILTKKGKNEDNRRKVNIMLLNGQRLELTCDTKTICKDV 597
            F  PEF+ +  E  ++L LP S++TKKGK+    R + ++LLNGQ LE+ CD ++    V
Sbjct: 308  FSRPEFILLAGEAPMTLHLPGSVVTKKGKSYLALRDLCVVLLNGQHLEVKCDVESTVGAV 367

Query: 598  FDMVVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTKVAPEGWKEEPKKKTKATVNFTLF 657
            F+ V +   L E   F LA +K  E+FF+D + +L K+APEGW+E+P+K +  T  FTLF
Sbjct: 368  FNAVTSFANLEELTYFGLAYMKSKEFFFLDSETRLCKIAPEGWREQPQKTSMNT--FTLF 425

Query: 658  FRIKFFMDDVSLIQHTLTCHQYYLQLRKDILEERMHCDDETSLLLASLALQAEYGDYQPE 717
             RIKFF+    L+QH+LT HQ+YLQLRKDILEER++C++E  L L  LALQAE+G+Y  E
Sbjct: 426  LRIKFFVSHYGLLQHSLTRHQFYLQLRKDILEERLYCNEEILLQLGVLALQAEFGNYPKE 485

Query: 718  -VHGVSYFRMEHYLPARVMEKLDLSYIKEELPKLHNTYVGASEKETELEFLKVCQRLTEY 776
             V    YF +E Y+PA ++E++    ++ E+ ++H        ++ EL+FL+V Q+L EY
Sbjct: 486  QVESKPYFHVEDYIPASLIERMTALRVQVEVSEMHRLSSALWGEDAELKFLRVTQQLPEY 545

Query: 777  GVHFHRVHPEKKS-QTGILLGVCSKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKITL 835
            GV  H+V  EK+  +  + LG+C+KGV+V+EV N  R  +LRF WRET KIS  +KK T+
Sbjct: 546  GVLVHQVFSEKRRPEEEMALGICAKGVIVYEVKNNSRIAMLRFQWRETGKISTYQKKFTI 605

Query: 836  QNTSDGIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDIDVLHKRWSIVSS 895
             ++  G KH F TD++K  +YLL LCS QH F  QM + Q +              ++  
Sbjct: 606  TSSVTGKKHTFVTDSAKTSKYLLDLCSAQHGFNAQMGSGQPSH-------------VLFD 652

Query: 896  PEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSV--APGG--PADLDGCLKPGD 951
             ++ + + NL   A       +I  +++   +  +F+S +  A GG     +D     G 
Sbjct: 653  HDKFVQMANLSP-AHQARSKPLIWIQRLSCSENELFVSRLQGAAGGLLSTSMDNFNVDGS 711

Query: 952  RLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPK--EKISKVPSTPVHLTNEMKNYM 1009
            +      +   G S     E L++A      VI +P   + +S  P   +H  +  KN  
Sbjct: 712  KEAGAEGI---GRSPCTGREQLKSA-----CVIQKPMTWDSLSGPPVQSMHAGS--KNNR 761

Query: 1010 KKSSYMQ---DSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSL----SSQDSRT-- 1060
            +KS   +   +    +  +D H   G + +  E S     G+   S+     ++ ++T  
Sbjct: 762  RKSFIAEPGREIVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIK 821

Query: 1061 ---ESASLSQSQVNGFFASHLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPG 1117
               +  +L+   + GF   ++  +  Q S          SK        D  ++ T   G
Sbjct: 822  PGGQILALNHISLEGF-TFNMAVRMIQNSPDNIELIISQSKGVGGNN-PDEEKNSTANSG 879

Query: 1118 IS--DVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTF--------SS 1167
            +S  D+  +  +G       +++  QD  T + + +   +   ++  +          SS
Sbjct: 880  VSSTDILSFGYQGSL----LSHTQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSS 935

Query: 1168 SPPKP-----GDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIH 1222
             PP P     G+I+ VEL K D +LG SVTGG+NTSV +GGIYVK+++P G A  +G+I 
Sbjct: 936  CPPSPPEISAGEIYFVELVKEDGTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQIL 995

Query: 1223 KGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQN 1282
            +GDR+L V+GV L G THKQAV+ L   GQV  L+LE+         VP + Q   S  +
Sbjct: 996  QGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLER--------RVPRSTQQCPSAND 1047

Query: 1283 AQGQGPEKVKKTTQV----KDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINAS 1338
            + G     V   T +         VT+   FEVKL KN++GLGFSF + +      + + 
Sbjct: 1048 SMGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSD 1107

Query: 1339 IVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPP 1398
            +VR+K+LFPGQPA E+G I  GD+IL VNG S +GL  QEV+  LRG   EV LLLCRPP
Sbjct: 1108 LVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPP 1167

Query: 1399 PGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRR 1458
            PG LPE++    TP  S       + K+ ++ +C +  TS   ++            S R
Sbjct: 1168 PGALPELEQEWQTPELS-------ADKEFTRATCTDSCTSPILDQ----------EDSWR 1210

Query: 1459 DSYSDSSGSG 1468
            DS S  +G G
Sbjct: 1211 DSASPDAGEG 1220



 Score =  150 bits (379), Expect = 1e-35
 Identities = 88/208 (42%), Positives = 130/208 (62%), Gaps = 11/208 (5%)

Query: 3   VSLAEALEVRGGPLQEEEIWAVLNQSAESLQELFRKVSLADPAALGFIISPWSLLLLPSG 62
           V+LA AL+VRG  L EEEIW++L  +AE L E  R  S        +++ PWS LL  +G
Sbjct: 15  VTLASALQVRGEALSEEEIWSLLFLAAEQLLEDLRNDSS------DYVVCPWSALLSAAG 68

Query: 63  SVSFTDENISNQDLRAFTAPEVLQNQSLTSLSDVEKIHIYSLGMTLYWGADYEVPQSQPI 122
           S+SF    +S+ +   F APE+LQ QS     D  ++H+YSLGMTLYW A + VP  QP+
Sbjct: 69  SLSFQGR-VSHIEAAPFKAPELLQGQSEDEQPDASQMHVYSLGMTLYWSAGFHVPPHQPL 127

Query: 123 KLGDHLNSILLGMCEDVIYARVSVRTVLDACSAHIRNSNC--APSFSYVKHLVKLVLGNL 180
           +L + L+SILL MCED  + R ++++VL+AC  H +  +   AP+  +++ LV LVLG +
Sbjct: 128 QLCEPLHSILLTMCEDQPHRRCTLQSVLEACRVHEKEVSVYPAPAGLHIRRLVGLVLGTI 187

Query: 181 SGTDQ--LSCNSEQKPDRSQAIRDRLRG 206
           S  ++  +  +S  + +RS  +R RLRG
Sbjct: 188 SEVEKRVVEESSSVQQNRSYLLRKRLRG 215



 Score = 60.8 bits (146), Expect = 1e-08
 Identities = 73/277 (26%), Positives = 110/277 (39%), Gaps = 50/277 (18%)

Query: 1595 ELLITLIKSEKGSLGFTVTKG-NQRI---GCYVHDVIQD-PAKSDGRLKPGDRLIKVNDT 1649
            E+    +  E G+LGF+VT G N  +   G YV  ++   PA  +G++  GDRL++V+  
Sbjct: 947  EIYFVELVKEDGTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGV 1006

Query: 1650 DVTNMTHTDAVNLLRAASKTVRLVIGR-------------------------VLELPRIP 1684
             +  +TH  AV  L    +  RLV+ R                         V  LP  P
Sbjct: 1007 ILCGLTHKQAVQCLTGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAVSLVTALPGRP 1066

Query: 1685 MLPHLLPD-----ITLTCNKEELGFSL-------CGGHDSLYQVVYISDINPRSVAAIEG 1732
                 + D     + L  N   LGFS        C    S   +V I  + P   A   G
Sbjct: 1067 SSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKS--DLVRIKRLFPGQPAEENG 1124

Query: 1733 NLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRS----AVS 1788
             +   D+I  VNG ST+G+  +EV   L  +   + L   R     +P  ++      +S
Sbjct: 1125 AIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPELEQEWQTPELS 1184

Query: 1789 APKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEEINE 1825
            A K  +   +    SC+ P L   DS+   A  +  E
Sbjct: 1185 ADK--EFTRATCTDSCTSPILDQEDSWRDSASPDAGE 1219



 Score = 32.7 bits (73), Expect = 4.2
 Identities = 18/84 (21%), Positives = 39/84 (46%), Gaps = 5/84 (5%)

Query: 1598 ITLIKSEKGSLGFTVTKGNQR----IGCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVT 1652
            +TL +      GF + +G        G ++  +I   PA+    +KPG +++ +N   + 
Sbjct: 776  VTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLE 835

Query: 1653 NMTHTDAVNLLRAASKTVRLVIGR 1676
              T   AV +++ +   + L+I +
Sbjct: 836  GFTFNMAVRMIQNSPDNIELIISQ 859


>gi|109138573 protein tyrosine phosphatase, non-receptor type 20A
            isoform 8 [Homo sapiens]
          Length = 339

 Score =  239 bits (609), Expect = 3e-62
 Identities = 117/240 (48%), Positives = 156/240 (65%), Gaps = 1/240 (0%)

Query: 2041 GQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVG 2100
            G    NR KNRY++ILPYD+TRVPLG    YINAS+I+I    EE+ YIA QGPL +T+ 
Sbjct: 97   GNQPSNREKNRYRDILPYDSTRVPLGKSKDYINASYIRIVNCGEEYFYIATQGPLLSTID 156

Query: 2101 DFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFV 2160
            DFWQM+ E  S VIAM+T+E+EG  IKC  YWP  L K   + +  R+ L   Q L+ F+
Sbjct: 157  DFWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKKPLELKH-FRVFLENYQILQYFI 215

Query: 2161 VRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAG 2220
            +R   + +  T     +  L FT WPDH TP+  D  + +I Y R  H +GP++ HCSAG
Sbjct: 216  IRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSHLTGPMVVHCSAG 275

Query: 2221 IGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTRL 2280
            IGR+G  +C+DVV   I ++  F+I D+V  MR QR GMVQT++QY FCY ++L VL +L
Sbjct: 276  IGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLRKL 335


>gi|109138561 protein tyrosine phosphatase, non-receptor type 20A
            isoform 3 [Homo sapiens]
          Length = 411

 Score =  239 bits (609), Expect = 3e-62
 Identities = 117/240 (48%), Positives = 156/240 (65%), Gaps = 1/240 (0%)

Query: 2041 GQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVG 2100
            G    NR KNRY++ILPYD+TRVPLG    YINAS+I+I    EE+ YIA QGPL +T+ 
Sbjct: 169  GNQPSNREKNRYRDILPYDSTRVPLGKSKDYINASYIRIVNCGEEYFYIATQGPLLSTID 228

Query: 2101 DFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFV 2160
            DFWQM+ E  S VIAM+T+E+EG  IKC  YWP  L K   + +  R+ L   Q L+ F+
Sbjct: 229  DFWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKKPLELKH-FRVFLENYQILQYFI 287

Query: 2161 VRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAG 2220
            +R   + +  T     +  L FT WPDH TP+  D  + +I Y R  H +GP++ HCSAG
Sbjct: 288  IRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSHLTGPMVVHCSAG 347

Query: 2221 IGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTRL 2280
            IGR+G  +C+DVV   I ++  F+I D+V  MR QR GMVQT++QY FCY ++L VL +L
Sbjct: 348  IGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLRKL 407


>gi|109138557 protein tyrosine phosphatase, non-receptor type 20A
            isoform 1 [Homo sapiens]
          Length = 420

 Score =  239 bits (609), Expect = 3e-62
 Identities = 117/240 (48%), Positives = 156/240 (65%), Gaps = 1/240 (0%)

Query: 2041 GQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVG 2100
            G    NR KNRY++ILPYD+TRVPLG    YINAS+I+I    EE+ YIA QGPL +T+ 
Sbjct: 178  GNQPSNREKNRYRDILPYDSTRVPLGKSKDYINASYIRIVNCGEEYFYIATQGPLLSTID 237

Query: 2101 DFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFV 2160
            DFWQM+ E  S VIAM+T+E+EG  IKC  YWP  L K   + +  R+ L   Q L+ F+
Sbjct: 238  DFWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKKPLELKH-FRVFLENYQILQYFI 296

Query: 2161 VRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAG 2220
            +R   + +  T     +  L FT WPDH TP+  D  + +I Y R  H +GP++ HCSAG
Sbjct: 297  IRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSHLTGPMVVHCSAG 356

Query: 2221 IGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTRL 2280
            IGR+G  +C+DVV   I ++  F+I D+V  MR QR GMVQT++QY FCY ++L VL +L
Sbjct: 357  IGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLRKL 416


>gi|108802617 protein tyrosine phosphatase, non-receptor type 20
            isoform 8 [Homo sapiens]
          Length = 339

 Score =  239 bits (609), Expect = 3e-62
 Identities = 117/240 (48%), Positives = 156/240 (65%), Gaps = 1/240 (0%)

Query: 2041 GQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVG 2100
            G    NR KNRY++ILPYD+TRVPLG    YINAS+I+I    EE+ YIA QGPL +T+ 
Sbjct: 97   GNQPSNREKNRYRDILPYDSTRVPLGKSKDYINASYIRIVNCGEEYFYIATQGPLLSTID 156

Query: 2101 DFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFV 2160
            DFWQM+ E  S VIAM+T+E+EG  IKC  YWP  L K   + +  R+ L   Q L+ F+
Sbjct: 157  DFWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKKPLELKH-FRVFLENYQILQYFI 215

Query: 2161 VRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAG 2220
            +R   + +  T     +  L FT WPDH TP+  D  + +I Y R  H +GP++ HCSAG
Sbjct: 216  IRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSHLTGPMVVHCSAG 275

Query: 2221 IGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTRL 2280
            IGR+G  +C+DVV   I ++  F+I D+V  MR QR GMVQT++QY FCY ++L VL +L
Sbjct: 276  IGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLRKL 335


>gi|108802607 protein tyrosine phosphatase, non-receptor type 20
            isoform 3 [Homo sapiens]
          Length = 411

 Score =  239 bits (609), Expect = 3e-62
 Identities = 117/240 (48%), Positives = 156/240 (65%), Gaps = 1/240 (0%)

Query: 2041 GQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVG 2100
            G    NR KNRY++ILPYD+TRVPLG    YINAS+I+I    EE+ YIA QGPL +T+ 
Sbjct: 169  GNQPSNREKNRYRDILPYDSTRVPLGKSKDYINASYIRIVNCGEEYFYIATQGPLLSTID 228

Query: 2101 DFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFV 2160
            DFWQM+ E  S VIAM+T+E+EG  IKC  YWP  L K   + +  R+ L   Q L+ F+
Sbjct: 229  DFWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKKPLELKH-FRVFLENYQILQYFI 287

Query: 2161 VRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAG 2220
            +R   + +  T     +  L FT WPDH TP+  D  + +I Y R  H +GP++ HCSAG
Sbjct: 288  IRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSHLTGPMVVHCSAG 347

Query: 2221 IGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTRL 2280
            IGR+G  +C+DVV   I ++  F+I D+V  MR QR GMVQT++QY FCY ++L VL +L
Sbjct: 348  IGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLRKL 407


>gi|108802604 protein tyrosine phosphatase, non-receptor type 20
            isoform 1 [Homo sapiens]
          Length = 420

 Score =  239 bits (609), Expect = 3e-62
 Identities = 117/240 (48%), Positives = 156/240 (65%), Gaps = 1/240 (0%)

Query: 2041 GQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVG 2100
            G    NR KNRY++ILPYD+TRVPLG    YINAS+I+I    EE+ YIA QGPL +T+ 
Sbjct: 178  GNQPSNREKNRYRDILPYDSTRVPLGKSKDYINASYIRIVNCGEEYFYIATQGPLLSTID 237

Query: 2101 DFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFV 2160
            DFWQM+ E  S VIAM+T+E+EG  IKC  YWP  L K   + +  R+ L   Q L+ F+
Sbjct: 238  DFWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKKPLELKH-FRVFLENYQILQYFI 296

Query: 2161 VRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAG 2220
            +R   + +  T     +  L FT WPDH TP+  D  + +I Y R  H +GP++ HCSAG
Sbjct: 297  IRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSHLTGPMVVHCSAG 356

Query: 2221 IGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTRL 2280
            IGR+G  +C+DVV   I ++  F+I D+V  MR QR GMVQT++QY FCY ++L VL +L
Sbjct: 357  IGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLRKL 416


>gi|108802611 protein tyrosine phosphatase, non-receptor type 20
            isoform 5 [Homo sapiens]
          Length = 228

 Score =  214 bits (546), Expect = 6e-55
 Identities = 106/222 (47%), Positives = 143/222 (64%), Gaps = 1/222 (0%)

Query: 2059 DATRVPLGDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMT 2118
            D+TRVPLG    YINAS+I+I    EE+ YIA QGPL +T+ DFWQM+ E  S VIAM+T
Sbjct: 4    DSTRVPLGKSKDYINASYIRIVNCGEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMIT 63

Query: 2119 QEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHIS 2178
            +E+EG  IKC  YWP  L K   + +  R+ L   Q L+ F++R   + +  T     + 
Sbjct: 64   REIEGGIIKCYHYWPISLKKPLELKH-FRVFLENYQILQYFIIRMFQVVEKSTGTSHSVK 122

Query: 2179 HLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLIS 2238
             L FT WPDH TP+  D  + +I Y R  H +GP++ HCSAGIGR+G  +C+DVV   I 
Sbjct: 123  QLQFTKWPDHGTPASADSFIKYIRYARKSHLTGPMVVHCSAGIGRTGVFLCVDVVFCAIV 182

Query: 2239 QDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTRL 2280
            ++  F+I D+V  MR QR GMVQT++QY FCY ++L VL +L
Sbjct: 183  KNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLRKL 224


>gi|109138565 protein tyrosine phosphatase, non-receptor type 20A
            isoform 5 [Homo sapiens]
          Length = 228

 Score =  214 bits (546), Expect = 6e-55
 Identities = 106/222 (47%), Positives = 143/222 (64%), Gaps = 1/222 (0%)

Query: 2059 DATRVPLGDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMT 2118
            D+TRVPLG    YINAS+I+I    EE+ YIA QGPL +T+ DFWQM+ E  S VIAM+T
Sbjct: 4    DSTRVPLGKSKDYINASYIRIVNCGEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMIT 63

Query: 2119 QEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHIS 2178
            +E+EG  IKC  YWP  L K   + +  R+ L   Q L+ F++R   + +  T     + 
Sbjct: 64   REIEGGIIKCYHYWPISLKKPLELKH-FRVFLENYQILQYFIIRMFQVVEKSTGTSHSVK 122

Query: 2179 HLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLIS 2238
             L FT WPDH TP+  D  + +I Y R  H +GP++ HCSAGIGR+G  +C+DVV   I 
Sbjct: 123  QLQFTKWPDHGTPASADSFIKYIRYARKSHLTGPMVVHCSAGIGRTGVFLCVDVVFCAIV 182

Query: 2239 QDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTRL 2280
            ++  F+I D+V  MR QR GMVQT++QY FCY ++L VL +L
Sbjct: 183  KNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLRKL 224


>gi|241896926 protein tyrosine phosphatase, receptor type, H isoform 2
            precursor [Homo sapiens]
          Length = 937

 Score =  194 bits (492), Expect = 1e-48
 Identities = 107/261 (40%), Positives = 150/261 (57%), Gaps = 13/261 (4%)

Query: 2039 LIGQTKENRRKNRYKNILPYDATRVPLG---DEGG--YINASFIKIPVGKEEFVYIACQG 2093
            ++    EN  KNRY+N+LPYD +RVPL    +E G  YINASF+      +EF  IA QG
Sbjct: 659  MVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEF--IATQG 716

Query: 2094 PLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRM 2153
            PLP TVGDFW+++WEQ+S  + M+T  +E  ++KC+ YWP  L         LR+ LV  
Sbjct: 717  PLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWP--LDSQPCTHGHLRVTLVGE 774

Query: 2154 QQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMR----HIHR 2209
            + ++ + VR + L  ++ ++   +   ++ AWPDH  PS PD LL F   +R        
Sbjct: 775  EVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTME 834

Query: 2210 SGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFC 2269
             GP I HCSAG+GR+GTLI +DV+L  +  +        VR MR  R  MVQTE QY+F 
Sbjct: 835  GGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFL 894

Query: 2270 YQVILYVLTRLQAEEEQKQQP 2290
            +Q IL  L +      +K+ P
Sbjct: 895  HQCILRFLQQSAQAPAEKEVP 915


>gi|241896924 protein tyrosine phosphatase, receptor type, H isoform 1
            precursor [Homo sapiens]
          Length = 1115

 Score =  194 bits (492), Expect = 1e-48
 Identities = 107/261 (40%), Positives = 150/261 (57%), Gaps = 13/261 (4%)

Query: 2039 LIGQTKENRRKNRYKNILPYDATRVPLG---DEGG--YINASFIKIPVGKEEFVYIACQG 2093
            ++    EN  KNRY+N+LPYD +RVPL    +E G  YINASF+      +EF  IA QG
Sbjct: 837  MVASASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEF--IATQG 894

Query: 2094 PLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRM 2153
            PLP TVGDFW+++WEQ+S  + M+T  +E  ++KC+ YWP  L         LR+ LV  
Sbjct: 895  PLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWP--LDSQPCTHGHLRVTLVGE 952

Query: 2154 QQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMR----HIHR 2209
            + ++ + VR + L  ++ ++   +   ++ AWPDH  PS PD LL F   +R        
Sbjct: 953  EVMENWTVRELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTME 1012

Query: 2210 SGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFC 2269
             GP I HCSAG+GR+GTLI +DV+L  +  +        VR MR  R  MVQTE QY+F 
Sbjct: 1013 GGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFL 1072

Query: 2270 YQVILYVLTRLQAEEEQKQQP 2290
            +Q IL  L +      +K+ P
Sbjct: 1073 HQCILRFLQQSAQAPAEKEVP 1093


>gi|223941891 protein tyrosine phosphatase, non-receptor type 3
            isoform 6 [Homo sapiens]
          Length = 581

 Score =  190 bits (482), Expect = 2e-47
 Identities = 110/299 (36%), Positives = 156/299 (52%), Gaps = 5/299 (1%)

Query: 1981 FLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLI 2040
            F + DEL  L    + P     G  L+  +  L+  L+ G    + E L   KP      
Sbjct: 273  FKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITF 332

Query: 2041 GQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFV--YIACQGPLPTT 2098
             +  +N  KNRYK++LPYD TRV L     YINAS++ + +     V  YIA QGPLP T
Sbjct: 333  AKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHT 392

Query: 2099 VGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKG 2158
               FWQ++W+QK ++I M+T   E  + KC +YWP+      M      +          
Sbjct: 393  CAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPD--PPDVMNHGGFHIQCQSEDCTIA 450

Query: 2159 FVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIH-RSGPIITHC 2217
            +V R M + + QT E   ++HL + AWPDH  P    D L F++Y+R +   S P++ HC
Sbjct: 451  YVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHC 510

Query: 2218 SAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYV 2276
            SAGIGR+G L+ ++  + L  ++L     D+VR MR QR  MVQT  QY F  + IL V
Sbjct: 511  SAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRV 569



 Score = 39.7 bits (91), Expect = 0.034
 Identities = 56/256 (21%), Positives = 103/256 (40%), Gaps = 34/256 (13%)

Query: 1434 EQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDL------VTAPANISNSTWSSA 1487
            E++  S    M  ++ K+ +SP  R        S  D+L      +T   ++  +   S 
Sbjct: 30   EKNVLSQYWTMGSRNTKK-RSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSL 88

Query: 1488 LHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMAPGQSY 1547
              Q   + VSQ +S H+   S+ +      Y  QK         S+ S  P   APG   
Sbjct: 89   APQDSDSEVSQNRSPHQESLSENNP--AQSYLTQK---------SSSSVSPSSNAPGSC- 136

Query: 1548 QPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGS 1607
                +      +D +H   +++    E+ +    D  ++ + + +    LI +   E G 
Sbjct: 137  --SPDGVDQQLLDDFH--RVTKGGSTEDASQYYCDKNDNGDSYLV----LIRITPDEDGK 188

Query: 1608 LGFTVTKGNQRIGCYVHDVIQDPAKSDG---RLKPGDRLIKVNDTDVTNMTHTDAVNLLR 1664
             GF +  G  +    V   I   + +D    +L  GD+++ +N  D++  TH   V  ++
Sbjct: 189  FGFNLKGGVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIK 248

Query: 1665 AA----SKTVRLVIGR 1676
            A+    S+ + LVI R
Sbjct: 249  ASRESHSRELALVIRR 264


>gi|223941888 protein tyrosine phosphatase, non-receptor type 3
            isoform 5 [Homo sapiens]
          Length = 626

 Score =  190 bits (482), Expect = 2e-47
 Identities = 110/299 (36%), Positives = 156/299 (52%), Gaps = 5/299 (1%)

Query: 1981 FLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLI 2040
            F + DEL  L    + P     G  L+  +  L+  L+ G    + E L   KP      
Sbjct: 318  FKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITF 377

Query: 2041 GQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFV--YIACQGPLPTT 2098
             +  +N  KNRYK++LPYD TRV L     YINAS++ + +     V  YIA QGPLP T
Sbjct: 378  AKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHT 437

Query: 2099 VGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKG 2158
               FWQ++W+QK ++I M+T   E  + KC +YWP+      M      +          
Sbjct: 438  CAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPD--PPDVMNHGGFHIQCQSEDCTIA 495

Query: 2159 FVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIH-RSGPIITHC 2217
            +V R M + + QT E   ++HL + AWPDH  P    D L F++Y+R +   S P++ HC
Sbjct: 496  YVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHC 555

Query: 2218 SAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYV 2276
            SAGIGR+G L+ ++  + L  ++L     D+VR MR QR  MVQT  QY F  + IL V
Sbjct: 556  SAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRV 614



 Score = 38.9 bits (89), Expect = 0.059
 Identities = 58/269 (21%), Positives = 108/269 (40%), Gaps = 30/269 (11%)

Query: 1415 SPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVT 1474
            +PA     S +     S   +S     N  S + + + + P  R S +D+  + E   +T
Sbjct: 64   NPAMRRSLSVEHLETKSLPSRSPPITPNWRSPRLRHEIRKP--RHSSADNLAN-EMTYIT 120

Query: 1475 APANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNP 1534
               ++  +   S   Q   + VSQ +S H+   S+ +      Y  QK         S+ 
Sbjct: 121  ETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNP--AQSYLTQK---------SSS 169

Query: 1535 SPLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEV 1594
            S  P   APG       +      +D +H   +++    E+ +    D  ++ + + +  
Sbjct: 170  SVSPSSNAPGSC---SPDGVDQQLLDDFH--RVTKGGSTEDASQYYCDKNDNGDSYLV-- 222

Query: 1595 ELLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDG---RLKPGDRLIKVNDTDV 1651
              LI +   E G  GF +  G  +    V   I   + +D    +L  GD+++ +N  D+
Sbjct: 223  --LIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDI 280

Query: 1652 TNMTHTDAVNLLRAA----SKTVRLVIGR 1676
            +  TH   V  ++A+    S+ + LVI R
Sbjct: 281  SEHTHDQVVMFIKASRESHSRELALVIRR 309


>gi|223941885 protein tyrosine phosphatase, non-receptor type 3
            isoform 4 [Homo sapiens]
          Length = 737

 Score =  190 bits (482), Expect = 2e-47
 Identities = 110/299 (36%), Positives = 156/299 (52%), Gaps = 5/299 (1%)

Query: 1981 FLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLI 2040
            F + DEL  L    + P     G  L+  +  L+  L+ G    + E L   KP      
Sbjct: 429  FKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITF 488

Query: 2041 GQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFV--YIACQGPLPTT 2098
             +  +N  KNRYK++LPYD TRV L     YINAS++ + +     V  YIA QGPLP T
Sbjct: 489  AKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHT 548

Query: 2099 VGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKG 2158
               FWQ++W+QK ++I M+T   E  + KC +YWP+      M      +          
Sbjct: 549  CAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPD--PPDVMNHGGFHIQCQSEDCTIA 606

Query: 2159 FVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIH-RSGPIITHC 2217
            +V R M + + QT E   ++HL + AWPDH  P    D L F++Y+R +   S P++ HC
Sbjct: 607  YVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHC 666

Query: 2218 SAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYV 2276
            SAGIGR+G L+ ++  + L  ++L     D+VR MR QR  MVQT  QY F  + IL V
Sbjct: 667  SAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRV 725



 Score = 75.9 bits (185), Expect = 4e-13
 Identities = 50/187 (26%), Positives = 85/187 (45%), Gaps = 17/187 (9%)

Query: 686 DILEERMHCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDLSYIKE 745
           DI E R+ C   ++++LAS A+Q+ +GDY   +H   Y    H++P +  + L       
Sbjct: 2   DICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFL------T 55

Query: 746 ELPKLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVF 805
           ++  LH  + G  + E E  ++ + + L  YGV  H           +++G+ S GV V+
Sbjct: 56  KVESLHEQHSGLKQSEAESCYINIARTLDFYGVELH--SGRDLHNLDLMIGIASAGVAVY 113

Query: 806 EVHNGVRTLVLRFPWRETKKISFSKKKITL---QNTSDGIKH--GFQTDNSKICQYLLHL 860
             +         +PW    KISF +KK  +   Q  ++  +H   F   N + C+ L   
Sbjct: 114 RKY----ICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKS 169

Query: 861 CSYQHKF 867
           C   H F
Sbjct: 170 CVEHHTF 176



 Score = 39.7 bits (91), Expect = 0.034
 Identities = 56/256 (21%), Positives = 103/256 (40%), Gaps = 34/256 (13%)

Query: 1434 EQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDL------VTAPANISNSTWSSA 1487
            E++  S    M  ++ K+ +SP  R        S  D+L      +T   ++  +   S 
Sbjct: 186  EKNVLSQYWTMGSRNTKK-RSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSL 244

Query: 1488 LHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMAPGQSY 1547
              Q   + VSQ +S H+   S+ +      Y  QK         S+ S  P   APG   
Sbjct: 245  APQDSDSEVSQNRSPHQESLSENNP--AQSYLTQK---------SSSSVSPSSNAPGSC- 292

Query: 1548 QPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGS 1607
                +      +D +H   +++    E+ +    D  ++ + + +    LI +   E G 
Sbjct: 293  --SPDGVDQQLLDDFH--RVTKGGSTEDASQYYCDKNDNGDSYLV----LIRITPDEDGK 344

Query: 1608 LGFTVTKGNQRIGCYVHDVIQDPAKSDG---RLKPGDRLIKVNDTDVTNMTHTDAVNLLR 1664
             GF +  G  +    V   I   + +D    +L  GD+++ +N  D++  TH   V  ++
Sbjct: 345  FGFNLKGGVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIK 404

Query: 1665 AA----SKTVRLVIGR 1676
            A+    S+ + LVI R
Sbjct: 405  ASRESHSRELALVIRR 420


>gi|223941882 protein tyrosine phosphatase, non-receptor type 3
            isoform 3 [Homo sapiens]
          Length = 782

 Score =  190 bits (482), Expect = 2e-47
 Identities = 110/299 (36%), Positives = 156/299 (52%), Gaps = 5/299 (1%)

Query: 1981 FLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLI 2040
            F + DEL  L    + P     G  L+  +  L+  L+ G    + E L   KP      
Sbjct: 474  FKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITF 533

Query: 2041 GQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFV--YIACQGPLPTT 2098
             +  +N  KNRYK++LPYD TRV L     YINAS++ + +     V  YIA QGPLP T
Sbjct: 534  AKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHT 593

Query: 2099 VGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKG 2158
               FWQ++W+QK ++I M+T   E  + KC +YWP+      M      +          
Sbjct: 594  CAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPD--PPDVMNHGGFHIQCQSEDCTIA 651

Query: 2159 FVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIH-RSGPIITHC 2217
            +V R M + + QT E   ++HL + AWPDH  P    D L F++Y+R +   S P++ HC
Sbjct: 652  YVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHC 711

Query: 2218 SAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYV 2276
            SAGIGR+G L+ ++  + L  ++L     D+VR MR QR  MVQT  QY F  + IL V
Sbjct: 712  SAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRV 770



 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 61/240 (25%), Positives = 104/240 (43%), Gaps = 30/240 (12%)

Query: 686 DILEERMHCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDLSYIKE 745
           DI E R+ C   ++++LAS A+Q+ +GDY   +H   Y    H++P +  + L       
Sbjct: 2   DICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFL------T 55

Query: 746 ELPKLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVF 805
           ++  LH  + G  + E E  ++ + + L  YGV  H           +++G+ S GV V+
Sbjct: 56  KVESLHEQHSGLKQSEAESCYINIARTLDFYGVELH--SGRDLHNLDLMIGIASAGVAVY 113

Query: 806 EVHNGVRTLVLRFPWRETKKISFSKKKITL---QNTSDGIKH--GFQTDNSKICQYLLHL 860
             +         +PW    KISF +KK  +   Q  ++  +H   F   N + C+ L   
Sbjct: 114 RKY----ICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKS 169

Query: 861 CSYQHKFQLQMRARQSNQDAQDIDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGG 920
           C   H F      +      Q+ +VL + W++ S         N KK        ++IGG
Sbjct: 170 CVEHHTF-----FQAKKLLPQEKNVLSQYWTMGSR--------NTKKSVNNQYCKKVIGG 216



 Score = 38.9 bits (89), Expect = 0.059
 Identities = 58/269 (21%), Positives = 108/269 (40%), Gaps = 30/269 (11%)

Query: 1415 SPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVT 1474
            +PA     S +     S   +S     N  S + + + + P  R S +D+  + E   +T
Sbjct: 220  NPAMRRSLSVEHLETKSLPSRSPPITPNWRSPRLRHEIRKP--RHSSADNLAN-EMTYIT 276

Query: 1475 APANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNP 1534
               ++  +   S   Q   + VSQ +S H+   S+ +      Y  QK         S+ 
Sbjct: 277  ETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNP--AQSYLTQK---------SSS 325

Query: 1535 SPLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEV 1594
            S  P   APG       +      +D +H   +++    E+ +    D  ++ + + +  
Sbjct: 326  SVSPSSNAPGSC---SPDGVDQQLLDDFH--RVTKGGSTEDASQYYCDKNDNGDSYLV-- 378

Query: 1595 ELLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDG---RLKPGDRLIKVNDTDV 1651
              LI +   E G  GF +  G  +    V   I   + +D    +L  GD+++ +N  D+
Sbjct: 379  --LIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDI 436

Query: 1652 TNMTHTDAVNLLRAA----SKTVRLVIGR 1676
            +  TH   V  ++A+    S+ + LVI R
Sbjct: 437  SEHTHDQVVMFIKASRESHSRELALVIRR 465


>gi|223941879 protein tyrosine phosphatase, non-receptor type 3
            isoform 2 [Homo sapiens]
          Length = 868

 Score =  190 bits (482), Expect = 2e-47
 Identities = 110/299 (36%), Positives = 156/299 (52%), Gaps = 5/299 (1%)

Query: 1981 FLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLI 2040
            F + DEL  L    + P     G  L+  +  L+  L+ G    + E L   KP      
Sbjct: 560  FKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITF 619

Query: 2041 GQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFV--YIACQGPLPTT 2098
             +  +N  KNRYK++LPYD TRV L     YINAS++ + +     V  YIA QGPLP T
Sbjct: 620  AKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHT 679

Query: 2099 VGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKG 2158
               FWQ++W+QK ++I M+T   E  + KC +YWP+      M      +          
Sbjct: 680  CAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPD--PPDVMNHGGFHIQCQSEDCTIA 737

Query: 2159 FVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIH-RSGPIITHC 2217
            +V R M + + QT E   ++HL + AWPDH  P    D L F++Y+R +   S P++ HC
Sbjct: 738  YVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHC 797

Query: 2218 SAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYV 2276
            SAGIGR+G L+ ++  + L  ++L     D+VR MR QR  MVQT  QY F  + IL V
Sbjct: 798  SAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRV 856



 Score =  112 bits (281), Expect = 3e-24
 Identities = 79/279 (28%), Positives = 126/279 (45%), Gaps = 33/279 (11%)

Query: 597 VFDMVVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTKVAPEGWKEEPK---KKTKATVN 653
           + DMV  H+G+ E   F L    D+             V    W E  K   K+ K    
Sbjct: 54  LLDMVHNHLGVTEKEYFGLQHDDDS-------------VDSPRWLEASKAIRKQLKGGFP 100

Query: 654 FTLFFRIKFFMDDVSLIQHTLTCHQYYLQLRKDILEERMHCDDETSLLLASLALQAEYGD 713
            TL FR++FF+ D + +Q   T H Y+LQL+ DI E R+ C   ++++LAS A+Q+ +GD
Sbjct: 101 CTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSHFGD 160

Query: 714 YQPEVHGVSYFRMEHYLPARVMEKLDLSYIKEELPKLHNTYVGASEKETELEFLKVCQRL 773
           Y   +H   Y    H++P +  + L       ++  LH  + G  + E E  ++ + + L
Sbjct: 161 YNSSIHHPGYLSDSHFIPDQNEDFL------TKVESLHEQHSGLKQSEAESCYINIARTL 214

Query: 774 TEYGVHFHRVHPEKKSQTGILLGVCSKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKI 833
             YGV  H           +++G+ S GV V+  +         +PW    KISF +KK 
Sbjct: 215 DFYGVELH--SGRDLHNLDLMIGIASAGVAVYRKY----ICTSFYPWVNILKISFKRKKF 268

Query: 834 TL---QNTSDGIKH--GFQTDNSKICQYLLHLCSYQHKF 867
            +   Q  ++  +H   F   N + C+ L   C   H F
Sbjct: 269 FIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTF 307



 Score = 39.7 bits (91), Expect = 0.034
 Identities = 56/256 (21%), Positives = 103/256 (40%), Gaps = 34/256 (13%)

Query: 1434 EQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDL------VTAPANISNSTWSSA 1487
            E++  S    M  ++ K+ +SP  R        S  D+L      +T   ++  +   S 
Sbjct: 317  EKNVLSQYWTMGSRNTKK-RSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSL 375

Query: 1488 LHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMAPGQSY 1547
              Q   + VSQ +S H+   S+ +      Y  QK         S+ S  P   APG   
Sbjct: 376  APQDSDSEVSQNRSPHQESLSENNP--AQSYLTQK---------SSSSVSPSSNAPGSC- 423

Query: 1548 QPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGS 1607
                +      +D +H   +++    E+ +    D  ++ + + +    LI +   E G 
Sbjct: 424  --SPDGVDQQLLDDFH--RVTKGGSTEDASQYYCDKNDNGDSYLV----LIRITPDEDGK 475

Query: 1608 LGFTVTKGNQRIGCYVHDVIQDPAKSDG---RLKPGDRLIKVNDTDVTNMTHTDAVNLLR 1664
             GF +  G  +    V   I   + +D    +L  GD+++ +N  D++  TH   V  ++
Sbjct: 476  FGFNLKGGVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIK 535

Query: 1665 AA----SKTVRLVIGR 1676
            A+    S+ + LVI R
Sbjct: 536  ASRESHSRELALVIRR 551


>gi|223941876 protein tyrosine phosphatase, non-receptor type 3
            isoform 1 [Homo sapiens]
          Length = 913

 Score =  190 bits (482), Expect = 2e-47
 Identities = 110/299 (36%), Positives = 156/299 (52%), Gaps = 5/299 (1%)

Query: 1981 FLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLI 2040
            F + DEL  L    + P     G  L+  +  L+  L+ G    + E L   KP      
Sbjct: 605  FKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITF 664

Query: 2041 GQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFV--YIACQGPLPTT 2098
             +  +N  KNRYK++LPYD TRV L     YINAS++ + +     V  YIA QGPLP T
Sbjct: 665  AKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHT 724

Query: 2099 VGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKG 2158
               FWQ++W+QK ++I M+T   E  + KC +YWP+      M      +          
Sbjct: 725  CAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPD--PPDVMNHGGFHIQCQSEDCTIA 782

Query: 2159 FVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIH-RSGPIITHC 2217
            +V R M + + QT E   ++HL + AWPDH  P    D L F++Y+R +   S P++ HC
Sbjct: 783  YVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHC 842

Query: 2218 SAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYV 2276
            SAGIGR+G L+ ++  + L  ++L     D+VR MR QR  MVQT  QY F  + IL V
Sbjct: 843  SAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRV 901



 Score =  114 bits (285), Expect = 1e-24
 Identities = 90/332 (27%), Positives = 145/332 (43%), Gaps = 46/332 (13%)

Query: 597 VFDMVVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTKVAPEGWKEEPK---KKTKATVN 653
           + DMV  H+G+ E   F L    D+             V    W E  K   K+ K    
Sbjct: 54  LLDMVHNHLGVTEKEYFGLQHDDDS-------------VDSPRWLEASKAIRKQLKGGFP 100

Query: 654 FTLFFRIKFFMDDVSLIQHTLTCHQYYLQLRKDILEERMHCDDETSLLLASLALQAEYGD 713
            TL FR++FF+ D + +Q   T H Y+LQL+ DI E R+ C   ++++LAS A+Q+ +GD
Sbjct: 101 CTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSHFGD 160

Query: 714 YQPEVHGVSYFRMEHYLPARVMEKLDLSYIKEELPKLHNTYVGASEKETELEFLKVCQRL 773
           Y   +H   Y    H++P +  + L       ++  LH  + G  + E E  ++ + + L
Sbjct: 161 YNSSIHHPGYLSDSHFIPDQNEDFL------TKVESLHEQHSGLKQSEAESCYINIARTL 214

Query: 774 TEYGVHFHRVHPEKKSQTGILLGVCSKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKI 833
             YGV  H           +++G+ S GV V+  +         +PW    KISF +KK 
Sbjct: 215 DFYGVELH--SGRDLHNLDLMIGIASAGVAVYRKY----ICTSFYPWVNILKISFKRKKF 268

Query: 834 TL---QNTSDGIKH--GFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDIDVLHK 888
            +   Q  ++  +H   F   N + C+ L   C   H F      +      Q+ +VL +
Sbjct: 269 FIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTF-----FQAKKLLPQEKNVLSQ 323

Query: 889 RWSIVSSPEREITLVNLKKDAKYGLGFQIIGG 920
            W++ S         N KK        ++IGG
Sbjct: 324 YWTMGSR--------NTKKSVNNQYCKKVIGG 347



 Score = 38.9 bits (89), Expect = 0.059
 Identities = 58/269 (21%), Positives = 108/269 (40%), Gaps = 30/269 (11%)

Query: 1415 SPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVT 1474
            +PA     S +     S   +S     N  S + + + + P  R S +D+  + E   +T
Sbjct: 351  NPAMRRSLSVEHLETKSLPSRSPPITPNWRSPRLRHEIRKP--RHSSADNLAN-EMTYIT 407

Query: 1475 APANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNP 1534
               ++  +   S   Q   + VSQ +S H+   S+ +      Y  QK         S+ 
Sbjct: 408  ETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNP--AQSYLTQK---------SSS 456

Query: 1535 SPLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEV 1594
            S  P   APG       +      +D +H   +++    E+ +    D  ++ + + +  
Sbjct: 457  SVSPSSNAPGSC---SPDGVDQQLLDDFH--RVTKGGSTEDASQYYCDKNDNGDSYLV-- 509

Query: 1595 ELLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDG---RLKPGDRLIKVNDTDV 1651
              LI +   E G  GF +  G  +    V   I   + +D    +L  GD+++ +N  D+
Sbjct: 510  --LIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDI 567

Query: 1652 TNMTHTDAVNLLRAA----SKTVRLVIGR 1676
            +  TH   V  ++A+    S+ + LVI R
Sbjct: 568  SEHTHDQVVMFIKASRESHSRELALVIRR 596


>gi|33356177 protein tyrosine phosphatase, non-receptor type 11 [Homo
            sapiens]
          Length = 593

 Score =  189 bits (480), Expect = 3e-47
 Identities = 125/330 (37%), Positives = 175/330 (53%), Gaps = 31/330 (9%)

Query: 1989 VLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSK-----ELENLQ--ELKPLDQCLIG 2041
            VL + + L + +   A ++S +R L  L +     K     E E LQ  E K L     G
Sbjct: 209  VLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEG 268

Query: 2042 QTKENRRKNRYKNILPYDATRVPLGDE------GGYINASFI------KIPVGKEEFVYI 2089
            Q +EN+ KNRYKNILP+D TRV L D         YINA+ I      K    K +  YI
Sbjct: 269  QRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYI 328

Query: 2090 ACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLA 2149
            A QG L  TV DFW+M++++ S VI M T+EVE  K KC +YWP+           +R+ 
Sbjct: 329  ATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEY--GVMRVR 386

Query: 2150 LVRMQQLKGFVVRAMTLEDI-QTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRH-- 2206
             V+      + +R + L  + Q    R +   +F  WPDH  PS P  +L F+  + H  
Sbjct: 387  NVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQ 446

Query: 2207 --IHRSGPIITHCSAGIGRSGTLICIDVVLGLISQ---DLDFDISDLVRCMRLQRHGMVQ 2261
              I  +GP++ HCSAGIGR+GT I ID+++ +I +   D D D+   ++ +R QR GMVQ
Sbjct: 447  ESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQ 506

Query: 2262 TEDQYIFCYQVILYVLTRLQ--AEEEQKQQ 2289
            TE QY F Y  + + +  LQ   EEEQK +
Sbjct: 507  TEAQYRFIYMAVQHYIETLQRRIEEEQKSK 536


>gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Homo
            sapiens]
          Length = 926

 Score =  186 bits (473), Expect = 2e-46
 Identities = 104/275 (37%), Positives = 156/275 (56%), Gaps = 9/275 (3%)

Query: 2007 KSVIRVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLG 2066
            +S+I++  GL+  G    + + L   KP       +  +N  KNRY++I PYDATRV L 
Sbjct: 641  ESMIQLAEGLIT-GTVLTQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILK 699

Query: 2067 DEGGYINASFIKIPVGKEEFV--YIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGE 2124
                YINA++I + +     +  YIACQGPLP T  DFWQM WEQ S+++ M+T +VE  
Sbjct: 700  GNEDYINANYINMEIPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERG 759

Query: 2125 KIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTA 2184
            ++KC +YWP   G ++      ++     +    ++ R MTL + +  E R ++ + + A
Sbjct: 760  RVKCHQYWPEPTGSSSY--GCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIA 817

Query: 2185 WPDHDTPSQPDDLLTFISYMRHIHRSG---PIITHCSAGIGRSGTLICIDVVLGLISQDL 2241
            WPDH  P    D L F+ ++R+  R+G   P++ HCSAGIGR+G LI ++  + LI  + 
Sbjct: 818  WPDHGVPDDSSDFLDFVCHVRN-KRAGKEEPVVVHCSAGIGRTGVLITMETAMCLIECNQ 876

Query: 2242 DFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYV 2276
                 D+VR MR QR  M+QT  QY F  + IL V
Sbjct: 877  PVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKV 911



 Score =  129 bits (323), Expect = 4e-29
 Identities = 90/300 (30%), Positives = 146/300 (48%), Gaps = 31/300 (10%)

Query: 575 NIMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALATLKDN--EYFFVDPDLKL 632
           NI+LL+        +     + + D+V  H+ L E   F L    D+     ++DP+  +
Sbjct: 32  NILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLADDSTDNPRWLDPNKPI 91

Query: 633 TKVAPEGWKEEPKKKTKATVNFTLFFRIKFFMDDVSLIQHTLTCHQYYLQLRKDILEERM 692
                       +K+ K    ++L FR+KFF+ D + +Q   T +QY+LQ+++DIL  R+
Sbjct: 92  ------------RKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRL 139

Query: 693 HCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDLSYIKEELPKLHN 752
            C   T+ LLAS A+Q+E GDY    +   Y     ++P +  +       ++E+ KLH 
Sbjct: 140 PCPSNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQD------FEKEIAKLHQ 193

Query: 753 TYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVFEVHNGVR 812
            ++G S  E E  +L   + L  YGV FH  +   +S   I++GV S G+L+++  N VR
Sbjct: 194 QHIGLSPAEAEFNYLNTARTLELYGVEFH--YARDQSNNEIMIGVMSGGILIYK--NRVR 249

Query: 813 TLVLRFPWRETKKISFSKKKITLQ-----NTSDGIKHGFQTDNSKICQYLLHLCSYQHKF 867
             +  FPW +  KISF  K+  +Q     + S     GF   N + C+ L   C   H F
Sbjct: 250 --MNTFPWLKIVKISFKCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTF 307



 Score = 41.6 bits (96), Expect = 0.009
 Identities = 43/188 (22%), Positives = 81/188 (43%), Gaps = 34/188 (18%)

Query: 870  QMRARQSNQDAQDIDVLHKRWSIVSSPER----------EITLVNLKKDAKYGLGFQIIG 919
            Q+    S QD +    +++ + I SSPE+           + L+ +K D     GF + G
Sbjct: 477  QIHYSHSQQDLESH--INETFDIPSSPEKPTPNGGIPHDNLVLIRMKPDENGRFGFNVKG 534

Query: 920  GEKMGRLDLGIFISSVAPGGPADLDGC---LKPGDRLISVNSVSLEGVSHHAAIEILQNA 976
            G       + + +S VAPG PADL  C   L  GD+++ +N   +   +H   +  ++ +
Sbjct: 535  GYDQ---KMPVIVSRVAPGTPADL--CVPRLNEGDQVVLINGRDIAEHTHDQVVLFIKAS 589

Query: 977  PE----DVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSA-IDSSSKDHHWSR 1031
             E    ++ L++          P+    +  E         Y+ + A +DS  +D H  R
Sbjct: 590  CERHSGELMLLVR---------PNAVYDVVEEKLENEPDFQYIPEKAPLDSVHQDDHSLR 640

Query: 1032 GTLRHISE 1039
             ++  ++E
Sbjct: 641  ESMIQLAE 648



 Score = 39.7 bits (91), Expect = 0.034
 Identities = 33/146 (22%), Positives = 57/146 (39%), Gaps = 11/146 (7%)

Query: 1524 PNKPEFEDSNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDL 1583
            P++    D  P  LPP  +   S+     S S   ++ +       P+  E  TP     
Sbjct: 452  PSQETPGDGKPPALPPKQSKKNSWNQIHYSHSQQDLESHINETFDIPSSPEKPTPNGGIP 511

Query: 1584 ENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSD---GRLKPG 1640
             ++L        +LI +   E G  GF V  G  +    +   +     +D    RL  G
Sbjct: 512  HDNL--------VLIRMKPDENGRFGFNVKGGYDQKMPVIVSRVAPGTPADLCVPRLNEG 563

Query: 1641 DRLIKVNDTDVTNMTHTDAVNLLRAA 1666
            D+++ +N  D+   TH   V  ++A+
Sbjct: 564  DQVVLINGRDIAEHTHDQVVLFIKAS 589


>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
            precursor [Homo sapiens]
          Length = 1907

 Score =  183 bits (464), Expect = 2e-45
 Identities = 94/240 (39%), Positives = 140/240 (58%), Gaps = 12/240 (5%)

Query: 2046 NRRKNRYKNILPYDATRVPLGDEGG-----YINASFIKIPVGKEEFVYIACQGPLPTTVG 2100
            N+ KNRY N++ YD +RV L    G     YINA++I     +++  YIA QGPLP T+G
Sbjct: 1375 NKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYID--GYRKQNAYIATQGPLPETMG 1432

Query: 2101 DFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFV 2160
            DFW+M+WEQ++  + MMT+  E  ++KC +YWP    + T     +++ L+   +L  + 
Sbjct: 1433 DFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWP---ARGTETCGLIQVTLLDTVELATYT 1489

Query: 2161 VRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHR--SGPIITHCS 2218
            VR   L    + E R +    F AWPDH  P  P  +L F+  ++  +   +GP++ HCS
Sbjct: 1490 VRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCS 1549

Query: 2219 AGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLT 2278
            AG+GR+G  I ID +L  +  +   DI   V CMR QR+ MVQTEDQY+F ++ +L   T
Sbjct: 1550 AGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAAT 1609



 Score =  150 bits (379), Expect = 1e-35
 Identities = 90/241 (37%), Positives = 127/241 (52%), Gaps = 14/241 (5%)

Query: 2046 NRRKNRYKNILPYDATRVPL----GDEGG-YINASFIKIPVGKEEFVYIACQGPLPTTVG 2100
            N+ KNR  NI+PY+ TRV L    G EG  YINASF+     +++  YIA QGPL  +  
Sbjct: 1664 NKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLD--GYRQQKAYIATQGPLAESTE 1721

Query: 2101 DFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFV 2160
            DFW+M+WE  ST+I M+T+  E  + KC +YWP              +A   M Q   ++
Sbjct: 1722 DFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQ---YI 1778

Query: 2161 VRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMR----HIHRSGPIITH 2216
            +R   + D +  + R I    FT WP+   P   +  + FI  +        + GPI  H
Sbjct: 1779 LREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVH 1838

Query: 2217 CSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYV 2276
            CSAG+GR+G  I + +VL  +  +   D+   V+ +R QR  MVQTEDQY  CY+  L  
Sbjct: 1839 CSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEY 1898

Query: 2277 L 2277
            L
Sbjct: 1899 L 1899


>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
            precursor [Homo sapiens]
          Length = 1898

 Score =  183 bits (464), Expect = 2e-45
 Identities = 94/240 (39%), Positives = 140/240 (58%), Gaps = 12/240 (5%)

Query: 2046 NRRKNRYKNILPYDATRVPLGDEGG-----YINASFIKIPVGKEEFVYIACQGPLPTTVG 2100
            N+ KNRY N++ YD +RV L    G     YINA++I     +++  YIA QGPLP T+G
Sbjct: 1366 NKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYID--GYRKQNAYIATQGPLPETMG 1423

Query: 2101 DFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFV 2160
            DFW+M+WEQ++  + MMT+  E  ++KC +YWP    + T     +++ L+   +L  + 
Sbjct: 1424 DFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWP---ARGTETCGLIQVTLLDTVELATYT 1480

Query: 2161 VRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHR--SGPIITHCS 2218
            VR   L    + E R +    F AWPDH  P  P  +L F+  ++  +   +GP++ HCS
Sbjct: 1481 VRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCS 1540

Query: 2219 AGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLT 2278
            AG+GR+G  I ID +L  +  +   DI   V CMR QR+ MVQTEDQY+F ++ +L   T
Sbjct: 1541 AGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAAT 1600



 Score =  150 bits (379), Expect = 1e-35
 Identities = 90/241 (37%), Positives = 127/241 (52%), Gaps = 14/241 (5%)

Query: 2046 NRRKNRYKNILPYDATRVPL----GDEGG-YINASFIKIPVGKEEFVYIACQGPLPTTVG 2100
            N+ KNR  NI+PY+ TRV L    G EG  YINASF+     +++  YIA QGPL  +  
Sbjct: 1655 NKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLD--GYRQQKAYIATQGPLAESTE 1712

Query: 2101 DFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFV 2160
            DFW+M+WE  ST+I M+T+  E  + KC +YWP              +A   M Q   ++
Sbjct: 1713 DFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQ---YI 1769

Query: 2161 VRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMR----HIHRSGPIITH 2216
            +R   + D +  + R I    FT WP+   P   +  + FI  +        + GPI  H
Sbjct: 1770 LREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVH 1829

Query: 2217 CSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYV 2276
            CSAG+GR+G  I + +VL  +  +   D+   V+ +R QR  MVQTEDQY  CY+  L  
Sbjct: 1830 CSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEY 1889

Query: 2277 L 2277
            L
Sbjct: 1890 L 1890


>gi|208431815 protein tyrosine phosphatase, receptor type, K isoform a
            [Homo sapiens]
          Length = 1446

 Score =  182 bits (462), Expect = 3e-45
 Identities = 100/246 (40%), Positives = 148/246 (60%), Gaps = 15/246 (6%)

Query: 2040 IGQTKENRRKNRYKNILPYDATRV---PLGDE--GGYINASFIKIPVGKEEFV----YIA 2090
            + +  +NR KNRY NI+ YD +RV   P+ D+    YINA++I I + ++ +     YIA
Sbjct: 905  VAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIA 964

Query: 2091 CQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLAL 2150
             QGP+  TV DFW+MIW+++S  I M+T  VE  ++KC +YWP+     T V    ++  
Sbjct: 965  TQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPD----DTEVYGDFKVTC 1020

Query: 2151 VRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIH-- 2208
            V M+ L  +VVR  TLE     E+R +   +FT WPDH  P     LL+FI  ++  +  
Sbjct: 1021 VEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPP 1080

Query: 2209 RSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIF 2268
             +GPI+ HCSAG GR+G  I ID++L +  ++   DI + V+ +R +R  MVQTE+QYIF
Sbjct: 1081 SAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIF 1140

Query: 2269 CYQVIL 2274
             +  IL
Sbjct: 1141 IHDAIL 1146



 Score = 84.7 bits (208), Expect = 9e-16
 Identities = 71/274 (25%), Positives = 114/274 (41%), Gaps = 34/274 (12%)

Query: 2025 ELENLQELKP---LDQCLIGQTKENRRKNRYKNILPYDATRVPL----GDEGGYINASFI 2077
            E + L  + P    + C I     N  KNR+ ++LP D     L    G+   YINA+ +
Sbjct: 1183 EFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALM 1242

Query: 2078 KIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILG 2137
                 ++   +I  Q PLP TV DFW+++++   T I M+  EV+  +  C +YWP    
Sbjct: 1243 DSY--RQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVML-NEVDLSQ-GCPQYWPE--- 1295

Query: 2138 KTTMVSNRLRLALVRMQQLK--------GFVVRAMTLEDIQTREVRHISHLNFTAWPDH- 2188
                    LR   ++++ +           + R   L   Q   +  +    +  W  H 
Sbjct: 1296 -----EGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLM-VQQFQYLGWASHR 1349

Query: 2189 DTPSQPDDLLTFISYMRHIHR-----SGPIITHCSAGIGRSGTLICIDVVLGLISQDLDF 2243
            + P      L  I  +           G  I HC  G GRSG    I +V+ ++ +    
Sbjct: 1350 EVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVV 1409

Query: 2244 DISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVL 2277
            D+   V+ +R  +  MV+  +QY FCY V L  L
Sbjct: 1410 DVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYL 1443


>gi|18104993 protein tyrosine phosphatase, non-receptor type 6 isoform
            3 [Homo sapiens]
          Length = 624

 Score =  182 bits (462), Expect = 3e-45
 Identities = 116/289 (40%), Positives = 160/289 (55%), Gaps = 23/289 (7%)

Query: 2024 KELENLQ--ELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGG------YINAS 2075
            +E E+LQ  E+K L Q L GQ  EN+ KNRYKNILP+D +RV L           YINA+
Sbjct: 246  EEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINAN 305

Query: 2076 FIKIPV-GKEEFV--YIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYW 2132
            +IK  + G +E    YIA QG L  TV DFWQM W++ S VI M T+EVE  + KC  YW
Sbjct: 306  YIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYW 365

Query: 2133 PNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTRE-VRHISHLNFTAWPDHDTP 2191
            P +            +          + +R + +  +   + +R I H  + +WPDH  P
Sbjct: 366  PEV--GMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVP 423

Query: 2192 SQPDDLLTFISYMRH----IHRSGPIITHCSAGIGRSGTLICIDVVLGLISQ---DLDFD 2244
            S+P  +L+F+  +      +  +GPII HCSAGIGR+GT+I ID+++  IS    D D D
Sbjct: 424  SEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDID 483

Query: 2245 ISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVL--TRLQAEEEQKQQPQ 2291
            I   ++ +R QR GMVQTE QY F Y  I   +  T+ + E  Q Q+ Q
Sbjct: 484  IQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQ 532


>gi|18104989 protein tyrosine phosphatase, non-receptor type 6 isoform
            1 [Homo sapiens]
          Length = 595

 Score =  182 bits (462), Expect = 3e-45
 Identities = 116/289 (40%), Positives = 160/289 (55%), Gaps = 23/289 (7%)

Query: 2024 KELENLQ--ELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGG------YINAS 2075
            +E E+LQ  E+K L Q L GQ  EN+ KNRYKNILP+D +RV L           YINA+
Sbjct: 246  EEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINAN 305

Query: 2076 FIKIPV-GKEEFV--YIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYW 2132
            +IK  + G +E    YIA QG L  TV DFWQM W++ S VI M T+EVE  + KC  YW
Sbjct: 306  YIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYW 365

Query: 2133 PNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTRE-VRHISHLNFTAWPDHDTP 2191
            P +            +          + +R + +  +   + +R I H  + +WPDH  P
Sbjct: 366  PEV--GMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVP 423

Query: 2192 SQPDDLLTFISYMRH----IHRSGPIITHCSAGIGRSGTLICIDVVLGLISQ---DLDFD 2244
            S+P  +L+F+  +      +  +GPII HCSAGIGR+GT+I ID+++  IS    D D D
Sbjct: 424  SEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDID 483

Query: 2245 ISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVL--TRLQAEEEQKQQPQ 2291
            I   ++ +R QR GMVQTE QY F Y  I   +  T+ + E  Q Q+ Q
Sbjct: 484  IQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQ 532


>gi|18104991 protein tyrosine phosphatase, non-receptor type 6 isoform
            2 [Homo sapiens]
          Length = 597

 Score =  182 bits (462), Expect = 3e-45
 Identities = 116/289 (40%), Positives = 160/289 (55%), Gaps = 23/289 (7%)

Query: 2024 KELENLQ--ELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGG------YINAS 2075
            +E E+LQ  E+K L Q L GQ  EN+ KNRYKNILP+D +RV L           YINA+
Sbjct: 248  EEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINAN 307

Query: 2076 FIKIPV-GKEEFV--YIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYW 2132
            +IK  + G +E    YIA QG L  TV DFWQM W++ S VI M T+EVE  + KC  YW
Sbjct: 308  YIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYW 367

Query: 2133 PNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTRE-VRHISHLNFTAWPDHDTP 2191
            P +            +          + +R + +  +   + +R I H  + +WPDH  P
Sbjct: 368  PEV--GMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVP 425

Query: 2192 SQPDDLLTFISYMRH----IHRSGPIITHCSAGIGRSGTLICIDVVLGLISQ---DLDFD 2244
            S+P  +L+F+  +      +  +GPII HCSAGIGR+GT+I ID+++  IS    D D D
Sbjct: 426  SEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDID 485

Query: 2245 ISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVL--TRLQAEEEQKQQPQ 2291
            I   ++ +R QR GMVQTE QY F Y  I   +  T+ + E  Q Q+ Q
Sbjct: 486  IQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQ 534


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.131    0.376 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 90,060,066
Number of Sequences: 37866
Number of extensions: 4313655
Number of successful extensions: 14646
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 279
Number of HSP's successfully gapped in prelim test: 195
Number of HSP's that attempted gapping in prelim test: 11827
Number of HSP's gapped (non-prelim): 2136
length of query: 2294
length of database: 18,247,518
effective HSP length: 118
effective length of query: 2176
effective length of database: 13,779,330
effective search space: 29983822080
effective search space used: 29983822080
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.