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Search of human proteins with 18254466
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|18254466 suppressor of cytokine signaling 4 [Homo sapiens]
(440 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|40807480 suppressor of cytokine signaling 4 [Homo sapiens] 919 0.0
gi|18254466 suppressor of cytokine signaling 4 [Homo sapiens] 919 0.0
gi|21618354 suppressor of cytokine signaling 5 [Homo sapiens] 434 e-122
gi|7662240 suppressor of cytokine signaling 5 [Homo sapiens] 434 e-122
gi|21450785 suppressor of cytokine signaling 6 [Homo sapiens] 96 5e-20
gi|53831997 suppressor of cytokine signaling 7 [Homo sapiens] 79 8e-15
gi|195976771 cytokine-inducible SH2-containing protein isoform 1... 74 2e-13
gi|21614507 cytokine-inducible SH2-containing protein isoform 2 ... 74 2e-13
gi|4507263 suppressor of cytokine signaling-2 [Homo sapiens] 72 8e-13
gi|4507233 suppressor of cytokine signaling 1 [Homo sapiens] 52 8e-07
gi|45439352 suppressor of cytokine signaling 3 [Homo sapiens] 49 9e-06
gi|166795247 phosphoinositide-3-kinase, regulatory subunit 3 (p5... 41 0.002
gi|166795245 phosphoinositide-3-kinase, regulatory subunit 3 (p5... 41 0.002
gi|5453754 NCK adaptor protein 1 [Homo sapiens] 40 0.004
gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a ... 39 0.009
gi|41327710 v-crk sarcoma virus CT10 oncogene homolog isoform b ... 39 0.009
gi|158631203 dual adaptor of phosphotyrosine and 3-phosphoinosit... 39 0.009
gi|4826908 phosphoinositide-3-kinase, regulatory subunit 2 (beta... 39 0.012
gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens] 39 0.012
gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens] 39 0.012
gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens] 37 0.047
gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens] 37 0.047
gi|46195789 RAB40C, member RAS oncogene family [Homo sapiens] 37 0.047
gi|32455252 phosphoinositide-3-kinase, regulatory subunit 1 (alp... 35 0.14
gi|32455250 phosphoinositide-3-kinase, regulatory subunit 1 (alp... 35 0.14
gi|32455248 phosphoinositide-3-kinase, regulatory subunit 1 (alp... 35 0.14
gi|4757980 beta chimerin isoform 2 [Homo sapiens] 35 0.14
gi|56550077 RAB40A, member RAS oncogene family [Homo sapiens] 35 0.14
gi|117320537 phospholipase C, gamma 2 [Homo sapiens] 35 0.18
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 33 0.39
>gi|40807480 suppressor of cytokine signaling 4 [Homo sapiens]
Length = 440
Score = 919 bits (2376), Expect = 0.0
Identities = 440/440 (100%), Positives = 440/440 (100%)
Query: 1 MAENNENISKNVDVRPKTSRSRSADRKDGYVWSGKKLSWSKKSESYSDAETVNGIEKTEV 60
MAENNENISKNVDVRPKTSRSRSADRKDGYVWSGKKLSWSKKSESYSDAETVNGIEKTEV
Sbjct: 1 MAENNENISKNVDVRPKTSRSRSADRKDGYVWSGKKLSWSKKSESYSDAETVNGIEKTEV 60
Query: 61 SLRNQERKHSCSSIELDLDHSCGHRFLGRSLKQKLQDAVGQCFPIKNCSSRHSSGLPSKR 120
SLRNQERKHSCSSIELDLDHSCGHRFLGRSLKQKLQDAVGQCFPIKNCSSRHSSGLPSKR
Sbjct: 61 SLRNQERKHSCSSIELDLDHSCGHRFLGRSLKQKLQDAVGQCFPIKNCSSRHSSGLPSKR 120
Query: 121 KIHISELMLDKCPFPPRSDLAFRWHFIKRHTAPINSKSDEWVSTDLSQTELRDGQLKRRN 180
KIHISELMLDKCPFPPRSDLAFRWHFIKRHTAPINSKSDEWVSTDLSQTELRDGQLKRRN
Sbjct: 121 KIHISELMLDKCPFPPRSDLAFRWHFIKRHTAPINSKSDEWVSTDLSQTELRDGQLKRRN 180
Query: 181 MEENINCFSHTNVQPCVITTDNALCREGPMTGSVMNLVSNNSIEDSDMDSDDEILTLCTS 240
MEENINCFSHTNVQPCVITTDNALCREGPMTGSVMNLVSNNSIEDSDMDSDDEILTLCTS
Sbjct: 181 MEENINCFSHTNVQPCVITTDNALCREGPMTGSVMNLVSNNSIEDSDMDSDDEILTLCTS 240
Query: 241 SRKRNKPKWDLDDEILQLETPPKYHTQIDYVHCLVPDLLQINNNPCYWGVMDKYAAEALL 300
SRKRNKPKWDLDDEILQLETPPKYHTQIDYVHCLVPDLLQINNNPCYWGVMDKYAAEALL
Sbjct: 241 SRKRNKPKWDLDDEILQLETPPKYHTQIDYVHCLVPDLLQINNNPCYWGVMDKYAAEALL 300
Query: 301 EGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNFSFDAHDPCVFHSPDITGL 360
EGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNFSFDAHDPCVFHSPDITGL
Sbjct: 301 EGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNFSFDAHDPCVFHSPDITGL 360
Query: 361 LEHYKDPSACMFFEPLLSTPLIRTFPFSLQHICRTVICNCTTYDGIDALPIPSSMKLYLK 420
LEHYKDPSACMFFEPLLSTPLIRTFPFSLQHICRTVICNCTTYDGIDALPIPSSMKLYLK
Sbjct: 361 LEHYKDPSACMFFEPLLSTPLIRTFPFSLQHICRTVICNCTTYDGIDALPIPSSMKLYLK 420
Query: 421 EYHYKSKVRVLRIDAPEQQC 440
EYHYKSKVRVLRIDAPEQQC
Sbjct: 421 EYHYKSKVRVLRIDAPEQQC 440
>gi|18254466 suppressor of cytokine signaling 4 [Homo sapiens]
Length = 440
Score = 919 bits (2376), Expect = 0.0
Identities = 440/440 (100%), Positives = 440/440 (100%)
Query: 1 MAENNENISKNVDVRPKTSRSRSADRKDGYVWSGKKLSWSKKSESYSDAETVNGIEKTEV 60
MAENNENISKNVDVRPKTSRSRSADRKDGYVWSGKKLSWSKKSESYSDAETVNGIEKTEV
Sbjct: 1 MAENNENISKNVDVRPKTSRSRSADRKDGYVWSGKKLSWSKKSESYSDAETVNGIEKTEV 60
Query: 61 SLRNQERKHSCSSIELDLDHSCGHRFLGRSLKQKLQDAVGQCFPIKNCSSRHSSGLPSKR 120
SLRNQERKHSCSSIELDLDHSCGHRFLGRSLKQKLQDAVGQCFPIKNCSSRHSSGLPSKR
Sbjct: 61 SLRNQERKHSCSSIELDLDHSCGHRFLGRSLKQKLQDAVGQCFPIKNCSSRHSSGLPSKR 120
Query: 121 KIHISELMLDKCPFPPRSDLAFRWHFIKRHTAPINSKSDEWVSTDLSQTELRDGQLKRRN 180
KIHISELMLDKCPFPPRSDLAFRWHFIKRHTAPINSKSDEWVSTDLSQTELRDGQLKRRN
Sbjct: 121 KIHISELMLDKCPFPPRSDLAFRWHFIKRHTAPINSKSDEWVSTDLSQTELRDGQLKRRN 180
Query: 181 MEENINCFSHTNVQPCVITTDNALCREGPMTGSVMNLVSNNSIEDSDMDSDDEILTLCTS 240
MEENINCFSHTNVQPCVITTDNALCREGPMTGSVMNLVSNNSIEDSDMDSDDEILTLCTS
Sbjct: 181 MEENINCFSHTNVQPCVITTDNALCREGPMTGSVMNLVSNNSIEDSDMDSDDEILTLCTS 240
Query: 241 SRKRNKPKWDLDDEILQLETPPKYHTQIDYVHCLVPDLLQINNNPCYWGVMDKYAAEALL 300
SRKRNKPKWDLDDEILQLETPPKYHTQIDYVHCLVPDLLQINNNPCYWGVMDKYAAEALL
Sbjct: 241 SRKRNKPKWDLDDEILQLETPPKYHTQIDYVHCLVPDLLQINNNPCYWGVMDKYAAEALL 300
Query: 301 EGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNFSFDAHDPCVFHSPDITGL 360
EGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNFSFDAHDPCVFHSPDITGL
Sbjct: 301 EGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNFSFDAHDPCVFHSPDITGL 360
Query: 361 LEHYKDPSACMFFEPLLSTPLIRTFPFSLQHICRTVICNCTTYDGIDALPIPSSMKLYLK 420
LEHYKDPSACMFFEPLLSTPLIRTFPFSLQHICRTVICNCTTYDGIDALPIPSSMKLYLK
Sbjct: 361 LEHYKDPSACMFFEPLLSTPLIRTFPFSLQHICRTVICNCTTYDGIDALPIPSSMKLYLK 420
Query: 421 EYHYKSKVRVLRIDAPEQQC 440
EYHYKSKVRVLRIDAPEQQC
Sbjct: 421 EYHYKSKVRVLRIDAPEQQC 440
>gi|21618354 suppressor of cytokine signaling 5 [Homo sapiens]
Length = 536
Score = 434 bits (1117), Expect = e-122
Identities = 234/436 (53%), Positives = 295/436 (67%), Gaps = 15/436 (3%)
Query: 7 NISKNVD--VRPKTSRSRSADRKDGYVWSGKKL-SWSKKSESYSDAETVNGIEKTEVSLR 63
+I K+ D V P T +R W GKK S S K++S DA+ G +T L+
Sbjct: 93 SIEKDNDSCVTPGTRLARRDSYSRHAPWGGKKKHSCSTKTQSSLDADKKFG--RTRSGLQ 150
Query: 64 NQERKHSCSSIELDLDHSCGHRFLGRSLKQKLQDAVGQCFPIKNCSSRHSSGLPSKRKIH 123
+ER++ SS+ D+D RSL+Q+LQD VG CFP++ S + +KRKIH
Sbjct: 151 RRERRYGVSSVH-DMDSVSSRTVGSRSLRQRLQDTVGLCFPMRTYSKQSKPLFSNKRKIH 209
Query: 124 ISELMLDKCPFPPRSDLAFRWHFIKRHTAPINSKSDEWVSTD--LSQTELRDGQLKRR-- 179
+SELML+KCPFP SDLA +WH IK+HTAP++ S + + D L TE + +L+ R
Sbjct: 210 LSELMLEKCPFPAGSDLAQKWHLIKQHTAPVSPHSTFFDTFDPSLVSTEDEEDRLRERRR 269
Query: 180 -NMEENINCFSHTNVQPCVITTD-NALCREGPMTGSVMNLVSNNS--IEDSDMDSDDEIL 235
++EE ++ + + T N L + GP M +S +S I ++ DS+++
Sbjct: 270 LSIEEGVDPPPNAQIHTFEATAQVNPLYKLGPKLAPGMTEISGDSSAIPQANCDSEEDTT 329
Query: 236 TLCTSSRKRNKPKWDLDDEI-LQLETPPKYHTQIDYVHCLVPDLLQINNNPCYWGVMDKY 294
TLC SR++ + + D + + K HTQIDY+HCLVPDLLQI NPCYWGVMD+Y
Sbjct: 330 TLCLQSRRQKQRQISGDSHTHVSRQGAWKVHTQIDYIHCLVPDLLQITGNPCYWGVMDRY 389
Query: 295 AAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNFSFDAHDPCVFHS 354
AEALLEGKPEGTFLLRDSAQEDYLFSVSFRRY+RSLHARIEQWNHNFSFDAHDPCVFHS
Sbjct: 390 EAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSFDAHDPCVFHS 449
Query: 355 PDITGLLEHYKDPSACMFFEPLLSTPLIRTFPFSLQHICRTVICNCTTYDGIDALPIPSS 414
+TGLLEHYKDPS+CMFFEPLL+ L RTFPFSLQ+ICR VIC CTTYDGID LP+PS
Sbjct: 450 STVTGLLEHYKDPSSCMFFEPLLTISLNRTFPFSLQYICRAVICRCTTYDGIDGLPLPSM 509
Query: 415 MKLYLKEYHYKSKVRV 430
++ +LKEYHYK KVRV
Sbjct: 510 LQDFLKEYHYKQKVRV 525
>gi|7662240 suppressor of cytokine signaling 5 [Homo sapiens]
Length = 536
Score = 434 bits (1117), Expect = e-122
Identities = 234/436 (53%), Positives = 295/436 (67%), Gaps = 15/436 (3%)
Query: 7 NISKNVD--VRPKTSRSRSADRKDGYVWSGKKL-SWSKKSESYSDAETVNGIEKTEVSLR 63
+I K+ D V P T +R W GKK S S K++S DA+ G +T L+
Sbjct: 93 SIEKDNDSCVTPGTRLARRDSYSRHAPWGGKKKHSCSTKTQSSLDADKKFG--RTRSGLQ 150
Query: 64 NQERKHSCSSIELDLDHSCGHRFLGRSLKQKLQDAVGQCFPIKNCSSRHSSGLPSKRKIH 123
+ER++ SS+ D+D RSL+Q+LQD VG CFP++ S + +KRKIH
Sbjct: 151 RRERRYGVSSVH-DMDSVSSRTVGSRSLRQRLQDTVGLCFPMRTYSKQSKPLFSNKRKIH 209
Query: 124 ISELMLDKCPFPPRSDLAFRWHFIKRHTAPINSKSDEWVSTD--LSQTELRDGQLKRR-- 179
+SELML+KCPFP SDLA +WH IK+HTAP++ S + + D L TE + +L+ R
Sbjct: 210 LSELMLEKCPFPAGSDLAQKWHLIKQHTAPVSPHSTFFDTFDPSLVSTEDEEDRLRERRR 269
Query: 180 -NMEENINCFSHTNVQPCVITTD-NALCREGPMTGSVMNLVSNNS--IEDSDMDSDDEIL 235
++EE ++ + + T N L + GP M +S +S I ++ DS+++
Sbjct: 270 LSIEEGVDPPPNAQIHTFEATAQVNPLYKLGPKLAPGMTEISGDSSAIPQANCDSEEDTT 329
Query: 236 TLCTSSRKRNKPKWDLDDEI-LQLETPPKYHTQIDYVHCLVPDLLQINNNPCYWGVMDKY 294
TLC SR++ + + D + + K HTQIDY+HCLVPDLLQI NPCYWGVMD+Y
Sbjct: 330 TLCLQSRRQKQRQISGDSHTHVSRQGAWKVHTQIDYIHCLVPDLLQITGNPCYWGVMDRY 389
Query: 295 AAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNFSFDAHDPCVFHS 354
AEALLEGKPEGTFLLRDSAQEDYLFSVSFRRY+RSLHARIEQWNHNFSFDAHDPCVFHS
Sbjct: 390 EAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSFDAHDPCVFHS 449
Query: 355 PDITGLLEHYKDPSACMFFEPLLSTPLIRTFPFSLQHICRTVICNCTTYDGIDALPIPSS 414
+TGLLEHYKDPS+CMFFEPLL+ L RTFPFSLQ+ICR VIC CTTYDGID LP+PS
Sbjct: 450 STVTGLLEHYKDPSSCMFFEPLLTISLNRTFPFSLQYICRAVICRCTTYDGIDGLPLPSM 509
Query: 415 MKLYLKEYHYKSKVRV 430
++ +LKEYHYK KVRV
Sbjct: 510 LQDFLKEYHYKQKVRV 525
>gi|21450785 suppressor of cytokine signaling 6 [Homo sapiens]
Length = 535
Score = 96.3 bits (238), Expect = 5e-20
Identities = 62/168 (36%), Positives = 85/168 (50%), Gaps = 15/168 (8%)
Query: 271 VHCLVPDLLQINNNPCYWGVMDKYAAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYSRS 330
V L +L ++ YWG + ++ AE L P+G+FL+RDS+ + YL S+SFR + ++
Sbjct: 369 VTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKT 428
Query: 331 LHARIEQWNHNFSFDAHDPCVFHSPDITGLLEH-YKDPSACMFFEPLLSTPLIRTFPF-- 387
LH RIE N FSF P V I L+EH +D F P T+P
Sbjct: 429 LHTRIEHSNGRFSF-YEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYPVRL 487
Query: 388 -----------SLQHICRTVICNCTTYDGIDALPIPSSMKLYLKEYHY 424
SLQ++CR VI T D I LP+P+ MK YL+E HY
Sbjct: 488 TNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY 535
>gi|53831997 suppressor of cytokine signaling 7 [Homo sapiens]
Length = 581
Score = 79.0 bits (193), Expect = 8e-15
Identities = 53/168 (31%), Positives = 78/168 (46%), Gaps = 15/168 (8%)
Query: 287 YWGVMDKYAAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNFSFDA 346
YWG M+ AE L+GKP+G+FL+RDS+ Y+ S+SFR + H R+E + FS
Sbjct: 401 YWGPMNWEDAEMKLKGKPDGSFLVRDSSDPRYILSLSFRSQGITHHTRMEHYRGTFSLWC 460
Query: 347 H----DPCVFHSPDITGLLEHYKDPSACMFFEP----LLSTPLIRTFPF-------SLQH 391
H D C I + H K+ F L TP+ +P SLQH
Sbjct: 461 HPKFEDRCQSVVEFIKRAIMHSKNGKFLYFLRSRVPGLPPTPVQLLYPVSRFSNVKSLQH 520
Query: 392 ICRTVICNCTTYDGIDALPIPSSMKLYLKEYHYKSKVRVLRIDAPEQQ 439
+CR I D I LP+P + Y+++++Y + + E Q
Sbjct: 521 LCRFRIRQLVRIDHIPDLPLPKPLISYIRKFYYYDPQEEVYLSLKEAQ 568
>gi|195976771 cytokine-inducible SH2-containing protein isoform 1
[Homo sapiens]
Length = 275
Score = 74.3 bits (181), Expect = 2e-13
Identities = 56/207 (27%), Positives = 88/207 (42%), Gaps = 40/207 (19%)
Query: 257 QLETPPKYHTQIDYVHCLVPDLLQINNNPCYWGVMDKYAAEALLEGKPEGTFLLRDSAQE 316
Q E+ PK + + C+ + + YWG + A L+ PEGTFL+RDS
Sbjct: 70 QTESEPKVLDPEEDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHP 129
Query: 317 DYLFSVSFRRYSRSLHARIEQWNHNFSFDAH---DPCVFHSPDITGLLEHY--------- 364
YLF++S + + RIE + +F D++ P + PD+ L++HY
Sbjct: 130 SYLFTLSVKTTRGPTNVRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASCTADTR 189
Query: 365 ---KDPSACMFF---------EPLLSTP--------------LIRTFPFSLQHICRTVIC 398
DP+ +P L P + R+ SLQH+CR VI
Sbjct: 190 SDSPDPAPTPALPMPKEDAPSDPALPAPPPATAVHLKLVQPFVRRSSARSLQHLCRLVIN 249
Query: 399 NCTTYDGIDALPIPSSMKLYLKEYHYK 425
+D LP+P M YL++Y ++
Sbjct: 250 RLVA--DVDCLPLPRRMADYLRQYPFQ 274
>gi|21614507 cytokine-inducible SH2-containing protein isoform 2
[Homo sapiens]
Length = 258
Score = 74.3 bits (181), Expect = 2e-13
Identities = 56/207 (27%), Positives = 88/207 (42%), Gaps = 40/207 (19%)
Query: 257 QLETPPKYHTQIDYVHCLVPDLLQINNNPCYWGVMDKYAAEALLEGKPEGTFLLRDSAQE 316
Q E+ PK + + C+ + + YWG + A L+ PEGTFL+RDS
Sbjct: 53 QTESEPKVLDPEEDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHP 112
Query: 317 DYLFSVSFRRYSRSLHARIEQWNHNFSFDAH---DPCVFHSPDITGLLEHY--------- 364
YLF++S + + RIE + +F D++ P + PD+ L++HY
Sbjct: 113 SYLFTLSVKTTRGPTNVRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASCTADTR 172
Query: 365 ---KDPSACMFF---------EPLLSTP--------------LIRTFPFSLQHICRTVIC 398
DP+ +P L P + R+ SLQH+CR VI
Sbjct: 173 SDSPDPAPTPALPMPKEDAPSDPALPAPPPATAVHLKLVQPFVRRSSARSLQHLCRLVIN 232
Query: 399 NCTTYDGIDALPIPSSMKLYLKEYHYK 425
+D LP+P M YL++Y ++
Sbjct: 233 RLVA--DVDCLPLPRRMADYLRQYPFQ 257
>gi|4507263 suppressor of cytokine signaling-2 [Homo sapiens]
Length = 198
Score = 72.4 bits (176), Expect = 8e-13
Identities = 56/166 (33%), Positives = 82/166 (49%), Gaps = 18/166 (10%)
Query: 274 LVPDLLQINNNPCYWGVMDKYAAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHA 333
L L ++ YWG M A+ L+ PEGTFL+RDS+ DYL ++S + + +
Sbjct: 36 LAKALRELGQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNL 95
Query: 334 RIEQWNHNFSFDAHDPCVFHS----PDITGLLEHY----KD----PSACM--FFEPLLST 379
RIE + F D+ CV + L+++Y KD P A L+
Sbjct: 96 RIEYQDGKFRLDS-IICVKSKLKQFDSVVHLIDYYVQMCKDKRTGPEAPRNGTVHLYLTK 154
Query: 380 PLIRTFPFSLQHICRTVICNCTTYDGIDALPIPSSMKLYLKEYHYK 425
PL + P SLQH+CR I CT I LP+P+ +K YL+EY ++
Sbjct: 155 PLYTSAP-SLQHLCRLTINKCT--GAIWGLPLPTRLKDYLEEYKFQ 197
>gi|4507233 suppressor of cytokine signaling 1 [Homo sapiens]
Length = 211
Score = 52.4 bits (124), Expect = 8e-07
Identities = 39/142 (27%), Positives = 60/142 (42%), Gaps = 14/142 (9%)
Query: 287 YWGVMDKYAAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNFSFDA 346
YWG + + A L +P GTFL+RDS Q + F++S + S R+ F D
Sbjct: 80 YWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDG 139
Query: 347 HD---PCVFHSPDITGLLEHYKDPSACMFFEPLLSTPLIRTFPFSLQHICRTVICNCTTY 403
C+F LLEHY M L PL + LQ +CR I
Sbjct: 140 SRESFDCLFE------LLEHYVAAPRRM-----LGAPLRQRRVRPLQELCRQRIVATVGR 188
Query: 404 DGIDALPIPSSMKLYLKEYHYK 425
+ + +P+ ++ YL + ++
Sbjct: 189 ENLARIPLNPVLRDYLSSFPFQ 210
>gi|45439352 suppressor of cytokine signaling 3 [Homo sapiens]
Length = 225
Score = 48.9 bits (115), Expect = 9e-06
Identities = 51/211 (24%), Positives = 91/211 (43%), Gaps = 47/211 (22%)
Query: 253 DEILQLETPPKYHTQIDYVHCLVPDLLQINNNPCYWGVMDKYAAEALLEGKPEGTFLLRD 312
D L+L+T + ++ +Y +V + ++ + YW + A LL +P GTFL+RD
Sbjct: 17 DTSLRLKT---FSSKSEY-QLVVNAVRKLQESGFYWSAVTGGEANLLLSAEPAGTFLIRD 72
Query: 313 SAQEDYLFSVSFRRYSRSLHARIEQWNHNFSFDAHDPCVFHSPD---ITGLLEHYKDPSA 369
S+ + + F++S + S + + RI+ +FS + P + L+ HY P
Sbjct: 73 SSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHYMPPPG 132
Query: 370 CMFF-----------------EPLLST---------------PLIRTFPFS-----LQHI 392
F +PL + PL+ + P S LQH+
Sbjct: 133 APSFPSPPTEPSSEVPEQPSAQPLPGSPPRRAYYIYSGGEKIPLVLSRPLSSNVATLQHL 192
Query: 393 CR-TVICNCTTYDGIDALPIPSSMKLYLKEY 422
CR TV + +Y+ + LP P ++ +L +Y
Sbjct: 193 CRKTVNGHLDSYEKVTQLPGP--IREFLDQY 221
>gi|166795247 phosphoinositide-3-kinase, regulatory subunit 3 (p55,
gamma) [Homo sapiens]
Length = 461
Score = 41.2 bits (95), Expect = 0.002
Identities = 40/144 (27%), Positives = 65/144 (45%), Gaps = 19/144 (13%)
Query: 287 YWGVMDKYAAEALLEGKPEGTFLLRDSA---QEDYLFSVSFRRYSRSLHARIEQWNHNFS 343
YWG + + L P+GTFL+RD++ Q DY +++ R+ + +I + +
Sbjct: 66 YWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDY--TLTLRKGGNNKLIKIYHRDGKYG 123
Query: 344 FDAHDPCVFHSPDITGLLEHYKDPSACMFFEPLLSTPLIRTFPFSLQHICRTVICNCTTY 403
F DP F+S + L+ HY S + P L L+ +P S + V
Sbjct: 124 FS--DPLTFNS--VVELINHYHHESLAQ-YNPKLDVKLM--YPVSRYQQDQLV-----KE 171
Query: 404 DGIDALPIPSSMKLYLKEYHYKSK 427
D IDA + ++ Y +Y KSK
Sbjct: 172 DNIDA--VGKKLQEYHSQYQEKSK 193
Score = 30.8 bits (68), Expect = 2.6
Identities = 15/31 (48%), Positives = 22/31 (70%), Gaps = 2/31 (6%)
Query: 288 WGVMD--KYAAEALLEGKPEGTFLLRDSAQE 316
W V D + AE LL GKP+G FL+R+S+++
Sbjct: 358 WFVEDINRVQAEDLLYGKPDGAFLIRESSKK 388
>gi|166795245 phosphoinositide-3-kinase, regulatory subunit 3 (p55,
gamma) [Homo sapiens]
Length = 461
Score = 41.2 bits (95), Expect = 0.002
Identities = 40/144 (27%), Positives = 65/144 (45%), Gaps = 19/144 (13%)
Query: 287 YWGVMDKYAAEALLEGKPEGTFLLRDSA---QEDYLFSVSFRRYSRSLHARIEQWNHNFS 343
YWG + + L P+GTFL+RD++ Q DY +++ R+ + +I + +
Sbjct: 66 YWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDY--TLTLRKGGNNKLIKIYHRDGKYG 123
Query: 344 FDAHDPCVFHSPDITGLLEHYKDPSACMFFEPLLSTPLIRTFPFSLQHICRTVICNCTTY 403
F DP F+S + L+ HY S + P L L+ +P S + V
Sbjct: 124 FS--DPLTFNS--VVELINHYHHESLAQ-YNPKLDVKLM--YPVSRYQQDQLV-----KE 171
Query: 404 DGIDALPIPSSMKLYLKEYHYKSK 427
D IDA + ++ Y +Y KSK
Sbjct: 172 DNIDA--VGKKLQEYHSQYQEKSK 193
Score = 30.8 bits (68), Expect = 2.6
Identities = 15/31 (48%), Positives = 22/31 (70%), Gaps = 2/31 (6%)
Query: 288 WGVMD--KYAAEALLEGKPEGTFLLRDSAQE 316
W V D + AE LL GKP+G FL+R+S+++
Sbjct: 358 WFVEDINRVQAEDLLYGKPDGAFLIRESSKK 388
>gi|5453754 NCK adaptor protein 1 [Homo sapiens]
Length = 377
Score = 40.0 bits (92), Expect = 0.004
Identities = 26/72 (36%), Positives = 39/72 (54%), Gaps = 5/72 (6%)
Query: 267 QIDYVHCLVPDLL-QINNNPCYWGVMDKYAAE-ALLEGKPEGTFLLRDSAQEDYLFSVSF 324
Q DY+ P L + NP Y+G + ++ AE AL E EG FL+RDS FSVS
Sbjct: 265 QCDYIR---PSLTGKFAGNPWYYGKVTRHQAEMALNERGHEGDFLIRDSESSPNDFSVSL 321
Query: 325 RRYSRSLHARIE 336
+ ++ H +++
Sbjct: 322 KAQGKNKHFKVQ 333
>gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a
[Homo sapiens]
Length = 304
Score = 38.9 bits (89), Expect = 0.009
Identities = 19/39 (48%), Positives = 26/39 (66%), Gaps = 2/39 (5%)
Query: 287 YWGVMDKYAAEALLEGKPEGTFLLRDSAQE--DYLFSVS 323
YWG + + A ALL+G+ G FL+RDS+ DY+ SVS
Sbjct: 14 YWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVS 52
>gi|41327710 v-crk sarcoma virus CT10 oncogene homolog isoform b
[Homo sapiens]
Length = 204
Score = 38.9 bits (89), Expect = 0.009
Identities = 19/39 (48%), Positives = 26/39 (66%), Gaps = 2/39 (5%)
Query: 287 YWGVMDKYAAEALLEGKPEGTFLLRDSAQE--DYLFSVS 323
YWG + + A ALL+G+ G FL+RDS+ DY+ SVS
Sbjct: 14 YWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVS 52
>gi|158631203 dual adaptor of phosphotyrosine and
3-phosphoinositides [Homo sapiens]
Length = 280
Score = 38.9 bits (89), Expect = 0.009
Identities = 22/59 (37%), Positives = 34/59 (57%), Gaps = 1/59 (1%)
Query: 287 YWGVMDKYAAEALLEGKP-EGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNFSF 344
Y G + ++AAEALL +G++LLRDS + L+S+S R H +E ++F F
Sbjct: 36 YHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAKDSVKHFHVEYTGYSFKF 94
>gi|4826908 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
[Homo sapiens]
Length = 728
Score = 38.5 bits (88), Expect = 0.012
Identities = 31/142 (21%), Positives = 65/142 (45%), Gaps = 15/142 (10%)
Query: 287 YWGVMDKYAAEALLEGKPEGTFLLRD-SAQEDYLFSVSFRRYSRSLHARIEQWNHNFSFD 345
YWG + + L P+GTFL+RD S++ ++++ R+ + ++ + ++ F
Sbjct: 331 YWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFS 390
Query: 346 AHDPCVFHSPDITGLLEHYKDPSACMFFEPLLSTPLIRTFPFSLQHICRTVICNCTTYDG 405
+P F S + L+ HY+ S + L + L + I + D
Sbjct: 391 --EPLTFCS--VVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQDQIVKE--------DS 438
Query: 406 IDALPIPSSMKLYLKEYHYKSK 427
++A + + +K+Y ++Y KS+
Sbjct: 439 VEA--VGAQLKVYHQQYQDKSR 458
Score = 33.5 bits (75), Expect = 0.39
Identities = 16/39 (41%), Positives = 24/39 (61%)
Query: 277 DLLQINNNPCYWGVMDKYAAEALLEGKPEGTFLLRDSAQ 315
DL Y G +++ AE +L GK +GTFL+R+S+Q
Sbjct: 613 DLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQ 651
>gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 38.5 bits (88), Expect = 0.012
Identities = 27/80 (33%), Positives = 43/80 (53%), Gaps = 6/80 (7%)
Query: 287 YWGVMDKYAAE-ALLEGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNFSFD 345
Y+G + ++ AE AL E EG FL+RDS FSVS + ++ H +++ ++ +
Sbjct: 286 YYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSVSLKASGKNKHFKVQLVDNVYCIG 345
Query: 346 AHDPCVFHSPDITGLLEHYK 365
FH+ D L+EHYK
Sbjct: 346 QRR---FHTMD--ELVEHYK 360
>gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 38.5 bits (88), Expect = 0.012
Identities = 27/80 (33%), Positives = 43/80 (53%), Gaps = 6/80 (7%)
Query: 287 YWGVMDKYAAE-ALLEGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNFSFD 345
Y+G + ++ AE AL E EG FL+RDS FSVS + ++ H +++ ++ +
Sbjct: 286 YYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSVSLKASGKNKHFKVQLVDNVYCIG 345
Query: 346 AHDPCVFHSPDITGLLEHYK 365
FH+ D L+EHYK
Sbjct: 346 QRR---FHTMD--ELVEHYK 360
>gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens]
Length = 1291
Score = 36.6 bits (83), Expect = 0.047
Identities = 34/101 (33%), Positives = 49/101 (48%), Gaps = 11/101 (10%)
Query: 293 KYAAEALLE------GKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARI--EQWNHNFSF 344
++ AE LL G P+G+FL+R+S +++SF R + H RI Q F
Sbjct: 562 RHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKF 621
Query: 345 DAHDPCVFHSPDITGLLEHYKD-PSACMFFEPLLSTPLIRT 384
D VF S + L+ HY+ P C FE LS P+ +T
Sbjct: 622 FLTDNLVFDS--LYDLITHYQQVPLRCNEFEMRLSEPVPQT 660
>gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens]
Length = 1290
Score = 36.6 bits (83), Expect = 0.047
Identities = 34/101 (33%), Positives = 49/101 (48%), Gaps = 11/101 (10%)
Query: 293 KYAAEALLE------GKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARI--EQWNHNFSF 344
++ AE LL G P+G+FL+R+S +++SF R + H RI Q F
Sbjct: 562 RHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKF 621
Query: 345 DAHDPCVFHSPDITGLLEHYKD-PSACMFFEPLLSTPLIRT 384
D VF S + L+ HY+ P C FE LS P+ +T
Sbjct: 622 FLTDNLVFDS--LYDLITHYQQVPLRCNEFEMRLSEPVPQT 660
>gi|46195789 RAB40C, member RAS oncogene family [Homo sapiens]
Length = 281
Score = 36.6 bits (83), Expect = 0.047
Identities = 45/183 (24%), Positives = 69/183 (37%), Gaps = 49/183 (26%)
Query: 287 YWGVMDKYAAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWN--HNFSF 344
Y +D LL+G+ L S Q F FR YSR + ++ + +SF
Sbjct: 45 YSNGIDYKTTTILLDGRRVRLELWDTSGQGR--FCTIFRSYSRGAQGILLVYDITNRWSF 102
Query: 345 DAHDPCVF----HSPDITGLL------------------EHYKDPSACMFFE--PLLSTP 380
D D + H+P + +L Y + + FFE PL +
Sbjct: 103 DGIDRWIKEIDEHAPGVPRILVGNRLHLAFKRQVPTEQARAYAEKNCMTFFEVSPLCNFN 162
Query: 381 LIRTFP---------------------FSLQHICRTVICNCTTYDGIDALPIPSSMKLYL 419
+I +F FSLQ +C I +CT ID LP+P ++K +L
Sbjct: 163 VIESFTELSRIVLMRHGMEKIWRPNRVFSLQDLCCRAIVSCTPVHLIDKLPLPVTIKSHL 222
Query: 420 KEY 422
K +
Sbjct: 223 KSF 225
>gi|32455252 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
isoform 2 [Homo sapiens]
Length = 454
Score = 35.0 bits (79), Expect = 0.14
Identities = 24/97 (24%), Positives = 47/97 (48%), Gaps = 6/97 (6%)
Query: 287 YWGVMDKYAAEALLEGKPEGTFLLRDSAQEDY-LFSVSFRRYSRSLHARIEQWNHNFSFD 345
YWG + + L +GTFL+RD++ + + ++++ R+ + +I + + F
Sbjct: 64 YWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFS 123
Query: 346 AHDPCVFHSPDITGLLEHYKDPSACMFFEPLLSTPLI 382
DP F S + L+ HY++ S + P L L+
Sbjct: 124 --DPLTFSS--VVELINHYRNESLAQ-YNPKLDVKLL 155
Score = 30.0 bits (66), Expect = 4.4
Identities = 13/28 (46%), Positives = 21/28 (75%)
Query: 289 GVMDKYAAEALLEGKPEGTFLLRDSAQE 316
G ++ AE LL GK +GTFL+R+S+++
Sbjct: 357 GSSNRNKAENLLRGKRDGTFLVRESSKQ 384
>gi|32455250 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
isoform 3 [Homo sapiens]
Length = 424
Score = 35.0 bits (79), Expect = 0.14
Identities = 24/97 (24%), Positives = 47/97 (48%), Gaps = 6/97 (6%)
Query: 287 YWGVMDKYAAEALLEGKPEGTFLLRDSAQEDY-LFSVSFRRYSRSLHARIEQWNHNFSFD 345
YWG + + L +GTFL+RD++ + + ++++ R+ + +I + + F
Sbjct: 34 YWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFS 93
Query: 346 AHDPCVFHSPDITGLLEHYKDPSACMFFEPLLSTPLI 382
DP F S + L+ HY++ S + P L L+
Sbjct: 94 --DPLTFSS--VVELINHYRNESLAQ-YNPKLDVKLL 125
Score = 30.0 bits (66), Expect = 4.4
Identities = 13/28 (46%), Positives = 21/28 (75%)
Query: 289 GVMDKYAAEALLEGKPEGTFLLRDSAQE 316
G ++ AE LL GK +GTFL+R+S+++
Sbjct: 327 GSSNRNKAENLLRGKRDGTFLVRESSKQ 354
>gi|32455248 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
isoform 1 [Homo sapiens]
Length = 724
Score = 35.0 bits (79), Expect = 0.14
Identities = 24/97 (24%), Positives = 47/97 (48%), Gaps = 6/97 (6%)
Query: 287 YWGVMDKYAAEALLEGKPEGTFLLRDSAQEDY-LFSVSFRRYSRSLHARIEQWNHNFSFD 345
YWG + + L +GTFL+RD++ + + ++++ R+ + +I + + F
Sbjct: 334 YWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFS 393
Query: 346 AHDPCVFHSPDITGLLEHYKDPSACMFFEPLLSTPLI 382
DP F S + L+ HY++ S + P L L+
Sbjct: 394 --DPLTFSS--VVELINHYRNESLAQ-YNPKLDVKLL 425
Score = 30.0 bits (66), Expect = 4.4
Identities = 13/28 (46%), Positives = 21/28 (75%)
Query: 289 GVMDKYAAEALLEGKPEGTFLLRDSAQE 316
G ++ AE LL GK +GTFL+R+S+++
Sbjct: 627 GSSNRNKAENLLRGKRDGTFLVRESSKQ 654
>gi|4757980 beta chimerin isoform 2 [Homo sapiens]
Length = 468
Score = 35.0 bits (79), Expect = 0.14
Identities = 39/169 (23%), Positives = 74/169 (43%), Gaps = 27/169 (15%)
Query: 219 SNNSIEDSDMDSDDEILTLCTSSRKRNKPKWDLDDEILQLETP-PKYHTQIDYVHCLVPD 277
SN+S+ S + SD E + P W LQ E P PK + P
Sbjct: 5 SNSSLSGSSVSSDAE---------EYQPPIWKSYLYQLQQEAPRPK--------RIICPR 47
Query: 278 LLQINNNPCYWG-----VMDKYAAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLH 332
++ N P Y+G ++ + A+ LL G EG ++LR+S ++ ++++ R +++L+
Sbjct: 48 --EVENRPKYYGREFHGIISREQADELLGGV-EGAYILRESQRQPGCYTLALRFGNQTLN 104
Query: 333 ARIEQWNHNFSFDAHDPCVFHSPDITGLLEHYKDPSACMFFEPLLSTPL 381
R+ +F + + H GL+ Y + A + + + P+
Sbjct: 105 YRLFHDGKHFVGEKRFESI-HDLVTDGLITLYIETKAAEYISKMTTNPI 152
>gi|56550077 RAB40A, member RAS oncogene family [Homo sapiens]
Length = 277
Score = 35.0 bits (79), Expect = 0.14
Identities = 14/35 (40%), Positives = 23/35 (65%)
Query: 388 SLQHICRTVICNCTTYDGIDALPIPSSMKLYLKEY 422
SLQ +C I +CT +D LP+PS+++ +LK +
Sbjct: 191 SLQDLCCRTIVSCTPVHLVDKLPLPSTLRSHLKSF 225
>gi|117320537 phospholipase C, gamma 2 [Homo sapiens]
Length = 1265
Score = 34.7 bits (78), Expect = 0.18
Identities = 31/101 (30%), Positives = 47/101 (46%), Gaps = 11/101 (10%)
Query: 290 VMDKYAAEALLE------GKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQW--NHN 341
V + +AE LL+ G +GTFL+R+S +++SF R R H RI
Sbjct: 537 VEKRTSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGT 596
Query: 342 FSFDAHDPCVFHSPDITGLLEHYKDPS-ACMFFEPLLSTPL 381
+ D F S I L++HY++ C FE L+ P+
Sbjct: 597 LKYYLTDNLTFSS--IYALIQHYRETHLRCAEFELRLTDPV 635
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 33.5 bits (75), Expect = 0.39
Identities = 19/49 (38%), Positives = 25/49 (51%)
Query: 287 YWGVMDKYAAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARI 335
Y G + + AAE LL G+FL+R+S S+S R R H RI
Sbjct: 159 YHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRI 207
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,037,222
Number of Sequences: 37866
Number of extensions: 823096
Number of successful extensions: 2096
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 47
Number of HSP's successfully gapped in prelim test: 24
Number of HSP's that attempted gapping in prelim test: 2019
Number of HSP's gapped (non-prelim): 86
length of query: 440
length of database: 18,247,518
effective HSP length: 105
effective length of query: 335
effective length of database: 14,271,588
effective search space: 4780981980
effective search space used: 4780981980
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.